baber/WOPTO huggingface dataset:
Patent DO-P2011000244-A (DO)
Title: Sistemas basados en conjugados para entrega farmacologica controlada
Inventor: ZION TODD C
Filed: 2011-07-28
Abstract: En un aspecto, la divulgación proporciona procedimientos para la preparación de medicamentos útiles para controlar los perfiles farmacocinéticos (PK) y/o farmacodinán-iicos (PD) de insulina en una forma que es sensible a las concentraciones sistémicas de un sacárido tal como Ia glucosa. Como se discutió en los Ejemplos, se descubrió que cuando Ia insulina fuera conjugada con ligandos sacáridos de alta afinidad, pudo hacerse exhibir perfiles PKJPD que respondieran a cambios de concentración sacárida aún en ausencia de una molécula multivalente y exógena fijadora de sacáridos tal como Con A. Este hallazgo fue inesperado y proporciona una oportunidad sin precedentes para generar sistemas simples de insulina sensibles a sacáridos libres de lectina. En otro aspecto, Ia divulgacíón proporciona conjugados y procedimientos de ejemplo para la fabricación de los mismos. En general, estos conjugados incluyen un fármaco y uno o más Iigandos separados en donde cada uno incluye un sacárido. En ciertas realizaciones, los ligandos son capaces de competir con un sacárido (por ejemplo, glucosa o manosa) para unirse a una molécula fijadora de sacáridos endógenos. En ciertas realizaciones, los ligandos son capaces de competir con la glucosa o manosa por Ia unión a Con A. Como se explica en detalle más adelante, en ciertas realizaciones, los ligandos y el fármaco pueden estar covalente o no covalentemente unidos a una estructura de conjugado. En ciertas realizaciones, la estructura es no polimérica. En ciertas realizaciones, un conjugado puede tener un índice de polidíspersidad de uno y un peso molecular de menos de 20.000 Da aproxìmadamente. En ciertas realizaciones, el conjugado es de larga duración (es decir, presenta un perfil farmacocinético que es más sostenido que la insulina humana recombinante soluble o RHI). Como está discutido en detalle más adelante, se debe entender que los métodos, conjugados y formulaciones que se describen en este documento no están limitados de ninguna manera a solamente la entrega de insulina y se debe entender que pueden ser utilizados para liberar cualquier medicamento. También se debe entender que Ios métodos se pueden utilizar para Iiberar fármacos en respuesta a sacárídos diferentes de la glucosa. En partícular, como se indica en los ejemplos, se ha demostrado que los conjugados de ejemplo responden a sacáridos exógenos como el alfa- metil manosa y L- fucosa. En ciertas realizaciones, esto puede utilizarse para preparar conjugados que pueden ser controlados por la administración de uno de estos sacáridos exógenos (es decir, en lugar de o además de ser controlados por las fluctuaciones en la glucosa endógena).
Patent DO-P2016000234-A (DO)
Title: Método de y sistema para crear y manejar un anuncio combinado que usa un dispositivo móvil.
Inventor: GAVIN MANNING
IPC: G06F17/30
Filed: 2016-09-09
Abstract: Se proporciona un método y un sistema de recopilación de uno o más anuncios. El método incluye la recepción a través de una red de comunicaciones de una solicitud de un anunciante para publicar un anuncio. El anunciante selecciona una o más categorías de productos y/o servicios para el que él o ella desea anunciar y luego recopila información con respecto a uno o más productos y/o servicios que será anunciado. La información se recopila para definir un anuncio primario. Un anuncio secundario se extrae a continuación, a partir de una base de datos y la adjunta a la publicidad primaria, a fin de definir un anuncio combinado que se transmite a un dispositivo de un usuario, típicamente un dispositivo de comunicaciones móviles. pic G06Q30/02; H04W4/14.
Patent DO-P2022000167-A (DO)
Title: Neoantígenos expresados en cáncer de ovario y sus usos
Inventor: VINOD KRISHNA
IPC: C07K14/47
Filed: 2022-08-12
Abstract: La descripción se relaciona con neoantígenos del cáncer de ovario, polinucleótidos que los codifican, vectores, células huésped, partículas de virus recombinantes, vacunas que comprenden los neoantígenos, moléculas proteináceas que se unen a los neoantígenos del cáncer de ovario, y métodos para elaborarlos y usarlos.
Patent EC-SP10010027-A (EC)
Title: Sistema y método para la conversión de energía de las olas en energía eléctrica
Inventor: DRAGIC MILE
IPC: F03B13/18
Filed: 2010-03-10
Abstract: La presente descripción se refiere a un proceso económico y ecológico para producir energía eléctrica. De acuerdo a la descripción, la energía eléctrica se produce por conversión de energía de las olas. En modalidades ilustrativas, las olas acuáticas levantan un cuerpo flotante el cual, por uso de un sistema de transmisión, mueve linealmente un imán en la bobina de inducción, o convierte movimiento vertical del cuerpo flotante en movimiento circular del generador el cual genera electricidad. El sistema que genera energía incluye ya sea eje de transmisión flexible o eje de transmisión rígido el cual transmite el movimiento a generadores de rotación o lineales. La presente descripción incluye el sistema para producir electricidad con soporte fijado al fondo del mar, y el sistema con cuerpos flotantes laterales y centrales, con generadores de rotación o lineales acoplados a los ejes de transmisiones posicionados por encima del sistema para producir electricidad.
Patent EE-200000769-A (EE)
Inventor: SCHUCKMANN ALFRED VON
IPC: A61M15/00
Filed: 1999-06-22
Abstract: The invention relates to a device (V) for emptying powder-containing cavities (1) sealed by means of a covering foil (9) by means of a suction tube (11) which can be set by hand and whose leading end is positioned relatively to the cavity (1) and pierces in a guided manner the covering foil (9), leaving a free cross section for air to flow into the cavity (1), and, to achieve a solution which is beneficial for production and reliable in manipulation, proposes that the leading end of the suction tube (11) has, adjacent and axially projecting with respect to cutting edges (12) provided at that point, extensions (22/82) which are guided in slots (19 and/or 83, 55 or 25, respectively) of a carrier (T) adjacent to the cavities (1) in a shape-locked/rotationally fixed manner, in which carrier (T) the cavities (1) can be inserted as blister packs (2).
Patent GB-189504869-A (GB)
Title: An Improved Tool for Expanding and Contracting Rings and the like.
Inventor: PERKINS ALFRED
Filed: 1895-03-07
Granted: 1896-01-25
Abstract: 4869. Perkins, A. March 7. Forging.-Relates to a tool for expanding and contracting finger rings, chain links, short tubes, &c., and consists of a headed plunger, Fig. 3, the stem f of which fits into the bore d of the block a formed with an external cone b and an internal cone c. In expanding a ring it is placed on the cone c and pressed down by the head g. In contracting a ring the block is reversed and the ring, placed in the conical opening c, is pressed down as before. When the head g does not reach the ring, a washer, Fig. 4, is used between the head and ring.
Patent GB-189700201-A (GB)
Title: Improved Corkscrew.
Inventor: VOIGT OTTO HEINRICH CHRISTIAN
Filed: 1897-01-04
Granted: 1897-04-10
Abstract: 201. Voigt, O. H. C. Jan. 4. Corkscrews.-The handle c is fixed on the screwed stem e of the corkscrew by the setscrew d, and the frame a is provided with an indiarubber washer b, which is adapted to bear on the mouth of the bottle and prevent it from being fractured. In use, the handle c is fixed to the stem, while the screw is being inserted in the cork, after which the handle is released and rotated on the stem, so as to raise the screw and withdraw the cork.
Patent GB-189707692-A (GB)
Title: Improvements in Apparatus for Recording and Checking Workmen's Time and for other similar purposes.
Inventor: WHITEHEAD WILLIAM
Filed: 1897-03-25
Granted: 1898-03-25
Abstract: 7692. Whitehead, W. March 25. Time-checking apparatus for workmen. A timestamp c' of the character described in Specifications No. 21,083, A.D. 1891, and No. 8513, A.D. 1894, is actuated from a control clock which periodically energizes the magnet h, rocks the armature g, and so operates the driving-pawl i of the ratchet-wheel k. When a workman arrives, he presses his numbered stamp into the funnel q<2> of a lever frame q pivoted at q<1>, taking an impression of the time and number on the strip e by means of the transfer strip d. A pin q<4> simultaneously actuates the spring hammer u of the bell v. The frame q carries a driving-pawl for the feed - mechanism of the transfer strip d and is connected by a link with the driving-pawl for the feed-rollers e', e<2> of the registering-strip e. Thus in the forward movement of the frame q slack in the strips is taken up, while in the return a fresh length of each is drawn off the supply rolls. As in the prior Specifications, the armature g is locked in position upon the magnet h while the stamp is in use. For this purpose the armature is linked to an arm z on a shaft z<1> connected by lever and link to a locking-lever operated by pins on the frame q.
Patent GB-189708692-A (GB)
Title: Improvements in and relating to Collapsable Boxes of Cardboard, Strawboard, Millboard, Leather-board, and like Materials.
Inventor: FRY ROBERT
Filed: 1897-04-06
Granted: 1897-06-12
Abstract: 8692. Fry, R., and Murrell, r. E. J. April 6. Drawings to Specification. Handles.-The lacing-fastening cord of folding- boxes may serve as a handle.
Patent GB-189710225-A (GB)
Title: Improvements in or connected with Steam and other Fluid Pressure Motors.
Inventor: WILCKE HENRY
Filed: 1897-04-24
Granted: 1898-04-23
Abstract: 10,225. Wilcke, H. April 24. Driving-gear, applicable specially to motors for road-and-rail vehicles, the chief object being to facilitate variations in speed. The road-wheels are driven from a shaft on which are keyed one or more discs having annular grooves b<1> in which are fitted two pairs of blocks c' held apart by wedges c, this arrangement constituting a sort of silent feed. Each wedge is connected to one end of a slotted lever, the other end of which receives a uniform reciprocation from the motor, and the fulcrum can be shifted in the slot, thereby varying the throw of the wedge c and the speed of rotation of the discs. In a modification, both the wedge c and inner block c' are pivoted to a lever, to the outer end of which the rod e is connected, the separation of the wedge and blocks on the sliding stroke being thus facilitated ; or, with the same object, the inner block may be retarded by a friction device. In another modification, Fig. 7, the lever d for varying the throw is connected directly with the wedge c and inner block c<1>; according to its position, moreover, with regard to the latter, the disc is driven in one or the other direction.
Patent GB-189712167-A (GB)
Title: Improvements in or relating to the Manufacture of Gloves.
Inventor: WALKER WILLIAM
Filed: 1897-05-17
Granted: 1898-04-02
Abstract: 12,167. Walker, W., and Kendrick, R. May 17. Knitting gloves. Putting-on work. In making gloves the hand is made on one machine and then transferred to a fingering-machine. This is effected by using a bar A to which is bolted a series of plates B carrying groups of transfer points C. The bar A has trunnions A' which are placed in springs A<4> on the frame A<6>, the springs causing the points to press the needle beards into the grooves. When the band fabrics are placed on the points and the bar A is placed on the fingering-frame, the loops may be pushed off by hand or by means of a toothed bar F, sliding on bars G acted on by springs F', guided by a bar H and moved towards the machine by levers K slotted at K<1> and engaging pins on bars J engaging the bar F. When the levers K are pulled to the position shown in dotted lines the loops are transferred simultaneously ; the springs withdraw the bar F.
Patent GB-189713099-A (GB)
Title: Improvements in Silvered Glass Reflectors for Incandescent Electric Lamps, and in the Method of Manufacturing such Reflectors.
Inventor: EDWARDS EDMUND
Filed: 1897-05-27
Granted: 1897-07-10
Abstract: 13,099. Edwards, E., [M³nzel, H.]. May 27. Re-heating; pressing.-Relates to reflectors for incandescent electric lamps of silvered glass. The glass, after being blown to the shape shown in Fig. 1, is re-heated and pressed to the form shown in Fig. 2, and the space A between the double walls is silvered. An opening to exactly fit the lamp holder is subsequently cut out at B by means of emery, and the upper part C of the blown glass is removed.
Patent GB-189716565-A (GB)
Title: Sky-lights with Primary and Secondary Prisms.
Inventor: EWEN JOHN MEIGGS
Filed: 1897-07-13
Granted: 1897-08-21
Abstract: 16,565. Ewen, J. M. July 13. Roof-lights.-The prisms are designed to project downwards the rays of light incident along the lines D<2>, E<1>, D, E. In the arrangement shown in Fig. 1, the rays E<1> are reflected by the plane surface B and refracted by the secondary or small prisms C<1>. In the arrangement shown in Fig. 2, some of the rays D are reflected by the surface B and refracted downwards on emerging from the face C.
Patent GB-189717833-A (GB)
Title: An Improvement in Apparatus for Compressing or Exhausting Elastic Fluid.
Inventor: BROTHERHOOD PETER
Filed: 1897-07-29
Granted: 1897-09-04
Abstract: 17,833. Brotherhood, P. July 29. Compressing; exhausting.-Three pump barrels F radiate from a central casing G, and their pistons E are connected to a common crank-pin the shaft A of which is carried in a long bearing in the framing B. For compressing, the air is drawn through ports h, and for exhausting, through the pipe H, and it enters the pump first through ports e, e<1> in the small ends of the connecting-rods D and pistons E respectively, and then through lateral ports f in the cylinder when these are uncovered by the piston. The air is discharged from the cylinders through valves H and pipes L, M.
Patent GB-189719364-A (GB)
Title: Improvements in Cross Border Jacquards.
Inventor: LANCASHIRE FREDERICK
Filed: 1897-08-21
Granted: 1898-07-02
Abstract: 19,364. Lancashire, F. Aug. 21. Jacquards. - In jacquards for cross - border weaving, the centre and border pattern cylinders A, A<1> are operated alternately from a connecting- rod D, having a head H with notches h, h<1> for engaging with either of the levers C, C<1>. The head is moved into engagement with either one or the other by a sliding bar G, operated by a crankpin k on a disc K, which is moved either by a hand chain k<1>, or automatically, after any given number of picks.
Patent GB-189719507-A (GB)
Title: Improvements in and relating to Pneumatic Tyres for the Wheels of Vehicles.
Inventor: GALLEY STUART VALENTINE
Filed: 1897-08-24
Granted: 1898-07-16
Abstract: 19,507. Galley, S. V. Aug. 24. Tyres, pneumatic ; felloes or rims.-The air tube B is secured in position within the metal rim A by means of a rubber or similar protecting-pad C, the projecting edges b, b<1> of which take under the inturned edges of the rim. Preferably, air spaces a are left between the air tube and the rim, but the air tube and protecting-pad may be formed in one piece. In Fig. 5, the rim A is shown double, and the edges may project further than shown.
Patent GB-189723175-A (GB)
Title: Improvements in Hardening, Enamel, and similar Kilns.
Inventor: CAPEWELL HENRY
Filed: 1897-10-09
Granted: 1898-10-01
Abstract: 23,175. Capewell, H. Oct. 9. Kilns for enamelling or hardening pottery and the like. Fig. 1 shows a sectional plan below the floor, and Fig. 4 a vertical cross-section. The fire-hole B leads into the flue G, which has a dividing-wall G<1> and branch flues G<2> communicating with the flue E. The flue G is at right-angles to the similarly-divided flue H, the branches of which also lead into the flue E, and is separated from the flue H by the wall H<3>. The walls G', H<1>, and H<3> have perforations G<4>, H<4>, H<5> respectively, and the floors of the flues G, H are inclined upwards from the firehole inwards, as shown at H' in Fig. 4. The kiln or oven proper D has vertical valves D<2> and an arched roof D<3>, the whole surrounded by the flue E, which is divided into a number of chambers, each having a damper-controlled opening E'. The kiln D has partition walls containing perforations F<2>.
Patent GB-189724260-A (GB)
Title: A Method and Apparatus for Separating Diamonds from Earthy Matters.
Inventor: LABRAM GEORGE
IPC: B07B13/00
Filed: 1897-10-20
Granted: 1898-07-30
Abstract: 24,260. Labram, G. Oct. 20. Separating diamonds.-Relates to apparatus for separating diamonds from earthy matters. Fig. 1 shows a front view and Fig. 2 a longitudinal section of the apparatus. The mixture of diamonds &c. is fed from a hopper A on to a distributing-plate C, whence it is washed by water jets from a pipe K on to an inclined suspended table, which may be made in steps F, on which are placed smooth iron plates J coated with grease, white lead, or the like, to which the diamonds adhere. The table is continually oscillated by the combined action of a cam G and spring S.
Patent GB-189727915-A (GB)
Title: Improvements in Steering Locks for Cycles.
Inventor: BOBBETT WILLIAM
Filed: 1897-11-27
Granted: 1898-11-05
Abstract: 27,915. Bobbett, W. Nov. 27. Locking-apparatus to prevent theft ; steering- mechanism, locking. A fork a, pivoted to a clip b encircling the steering-socket c, may be turned down to engage the brake rod, as shown in Fig. 1, and so prevent the steering-stem from turning. Or the fork a may be arranged to turn upwards and engage a lug on the head clip. Fig. 3 shows another form, in which a catch h, pivoted to a clip i encircling the top bar c, may be turned to engage one of a series of notches formed in a plate j secured to the head clip. Padlocks may be used to lock the parts in position, as shown, and so prevent theft.
Patent GB-189730105-A (GB)
Title: Improvements in and connected with Musical Instruments.
Inventor: GREEN HENRY EDWARD
Filed: 1897-12-20
Granted: 1898-12-17
Abstract: 30,105. Green, H. E. Dec. 20. Automatic instruments; pianofortes ; organs and like instruments. -Relates to a combination of an automatic musical instrument with a pianoforte, organ, harmonium, or other instrument, and especially to such an arrangement that the automatic part may be removed without interfering with the ordinary playing of the instrument. Fig. 1 shows the invention applied to, say, a harmonium. The instrument can be played by the keys P<1>, which operate the levers P, spring levers 0, and so the pallets O<2> controlling the passage of the wind thruugh the reeds B, B<1>. The upper part of the instrument, which is attached by screws C, C, carries the automatic mechanism. H is the perforated tune-sheet, driven by a pneumatic motor, and passing over a bridge D<1> and under a bridge D<2> which can be thrown out of action by pulling out the stop K when the sheet is to be re-wound. The tubes leading from the bridge are connected by tubes E to passages F<4>, F<5>, F<6>, F<7>, formed by grooving the boards F<2>, F<3>, and covering the grooves by thin boards F<8>, F<9>, F'‹. These grooves radiate to the holes G', G<3>, for the pneumatics G*, bye-passes L<6>, regulated by screws L<5>, connecting the holes and a wind-chest L. The pneumatics G* carry valves G<6>, G<7> which control the air flow to pneumatics or bellows N<2>, N<3> which, by means of hooked wires N<4>, lift the corresponding key levers 0 when inflated. Figs. 7 and 9 show the pneumatic motor for driving the tune-sheet. The crank Q<5> on the spindle Q‹ is rotated through the four links Q<7> by the successive inflation and deflation of the four bellows Q<1>, Q<2>, Q<3>, Q<4>. The end of the spindle Q<6> carries a disc Q<12> with crank-pin Q<13> working in slots arranged at right-angles in blocks Q<14>, Q<15>. The reciprocation of the blocks and of attached rods Q<17>, Q<17> actuates the spring valve Q<9>, Q" by means of adjustable buttons Q<20>, Q<22> so as to control the flow of air to and from the bellows through the passages Q<8>, Q<10>.
Patent GB-189803850-A (GB)
Title: Improvements in Holders for Electric Glow Lamps.
Inventor: GEIPEL WILLIAM
Filed: 1898-02-16
Granted: 1899-02-04
Abstract: 3850. Geipel, W., Lange, F. M. T., and Saltrick, W. R. R. Feb. 16. Incandescent l a m p s , holders for. A cylindrical insulator A is made with two deep cavities to receive plungercarriers F, as shown in plan, Fig. 3. Each plunger - carrier is constructed as shown in section in Fig. 2, with an inclined hole into which the supply wire is passed through a tapered hole C in the insulator. The w i r e is secured by a screw E placed so as to be accessible o v e r the edge of the insulator, which may be recessed for the purpose, if necessary. The tapering of the hole C permits the end of the insulating-covering on the wire to be placed within it.
Patent GB-189809738-A (GB)
Title: Improvements in and relating to Cameras and Projecting Apparatus for Kinematograph Pictures.
Inventor: ADAMS JAMES
Filed: 1898-04-28
Granted: 1899-04-08
Abstract: 9738. Adams, J. April 28. Kinematographic apparatus.-Relates to mechanism for feeding the ribbon intermittently in apparatus for taking photographs or for optical projection. The edges of the ribbon are perforated to gear with the teeth of the sprocket-wheels A, B. The ribbon R is drawn from the store spool S by the drum A. An intermittent movement is given to the ribbon as it passes the lens aperture I by a roller.J on the crank-pin of a rotating disc. Just before the end of the downward stroke of the ribbon, it is clamped by a clamp C actuated by a cam D. The ribbon then pulls down the roller E on the end of the spring-supported lever F. When the crank roller J begins to rise, the lever F pulls the perforations of the ribbon on to teeth, whereby the ribbon is held fast during exposure. After exposure, the ribbon is drawn on to the receiving-spool K by the driving-roller B.
Patent GB-189810911-A (GB)
Title: Improvements in or relating to Burners for Petroleum and other Hydrocarbons.
Inventor: BOULT ALFRED JULIUS
Filed: 1898-05-12
Granted: 1898-06-18
Abstract: 10,911. Boult, A. J., [Barthel, G.]. May 12. Vapour burners.- To prevent the choking of the burner r passages by carbonaceous deposits, and to facilitate the cleaning of the said passages, the vaporizing - chamber d is arranged within a solid casting c, and as near as possible to the burner proper g. The flame from the burner orifices m impinges upon the fixed or detachable flange h, which conducts the heat to the vaporizing-chamber d and to the air-supply passages e. The latter facilitate the cleaning of the vapour orifice i. A starting-cup b is provided on the supply pipe a.
Patent GB-189814000-A (GB)
Title: Pneumatic Tyres for Cycles and other Vehicles.
Inventor: RIDGWAY JOSEPH
Filed: 1898-06-24
Granted: 1899-06-24
Abstract: 14,000. Ridgway, J. June 24. Tyres, pneumatic. -The edges of the cover Care provided with flaps D, which overlap and are connected together by studs A and holes B or equivalent fastening-devices.
Patent GB-189818761-A (GB)
Title: Improvements in and connected with Motors Actuated by Explosive Gases or Vapours and by Steam.
Inventor: MARTIN WILLIAM FREDERICK
Filed: 1898-09-02
Granted: 1899-07-01
Abstract: 18,761. Martin, W. F. Sept. 2. Steam generators combined with gas engines.-In the form of motor shown there are two explosion cylinders 1 and 3, with a steam cylinder 2 between them, driving a three-throw crank shaft. The steam cylinder is worked by injecting into it water which is flashed into steam by the heat conducted from the explosion cylinders, or by steam generated in the jacket 11 or in a coil surrounding the explosion cylinders. The engine is reversible and suitable for motor cars.