Patent SG-11201908012S-A (SG)
Title: Cyclic sulfamide compounds and methods of using same
Inventor: TURNER WILLIAM
IPC: A61K31/549
Filed: 2018-03-01
Abstract: BrBC6B C5B F1B S1 B Br1A C7A 1A C4 N2A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT omit IIl °nolo Oil 100 iflo oimIE (10) International Publication Number WO 2018/160878 Al (51) International Patent Classification: C07D 417/04 (2006.01) A61P 31/12 (2006.01) C07D 417/14 (2006.01) A61K 31/549 (2006.01) (21) International Application Number: PCT/US2018/020515 (22) International Filing Date: 01 March 2018 (01.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/465,986 02 March 2017 (02.03.2017) US 62/529,874 07 July 2017 (07.07.2017) US 62/549,728 24 August 2017 (24.08.2017) US (71) Applicant: ASSEMBLY BIOSCIENCES, INC. [US/US]; 11711 N. Meridian Street, Suite 310, Cannel, IN 46032 (US). (72) Inventors: TURNER, William, W., Jr.; 3688 E. Tamaron Drive, Bloomington, IN 47408 (US). LI, Leping; 11711 N. Meridian Street, Suite 310, Cannel, IN 46032 (US). HAY- DAR, Simon, Nicolas; 11711 N. Meridian Street, Suite 310, Cannel, IN 46032 (US). BURES, Mark, G.; 11711 N. Meridian Street, Suite 310, Carmel, IN 46032 (US). RAI, Roopa; 11711 N. Meridian Street, Suite 310, Carmel, IN 46032 (US). FRANCIS, Samson; 351 West 10th Street, In- dianapolis, IN 46204 (US). ARNOLD, Lee, Daniel; 3751 East Sterling Avenue, Bloomington, IN 47401 (US). (74) Agent: UITTO, Olivia, D. et al.; Goodwin Procter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME 1-1 GC N GC 1-1 O (57) : The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful \" as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection. [Continued on next page] WO 2018/160878 Al D ill EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))