baber/WOPTO huggingface dataset:
Patent BR-112023005610-A2 (BR)
Title: Molécula de interleucina-2 modificada (il-2) e uso da mesma
Inventor: YAO ZHAO
IPC: C12N1/21
Filed: 2021-10-16
Abstract: MOLÉCULA DE INTERLEUCINA-2 MODIFICADA (IL-2) E USO DA MESMA. O presente pedido revela uma molécula de interleucina-2 (IL-2) modificada, em que a modificação inclui substituir uma região em uma molécula de IL-2 que medeia a ligação da molécula de IL-2 ao receptor alfa de interleucina-2 (IL2Ra) com uma região em uma molécula de interleucina-15 (IL-15) que medeia a ligação da molécula de IL-15 ao receptor alfa de interleucina-15 (IL15Ra). A região na molécula de IL-15 que medeia a ligação da molécula de IL-15 ao IL15Ra inclui 9 ou mais resíduos de aminoácidos. O presente pedido também revela um heterodímero de proteína que inclui a molécula de IL-2 modificada descrita no presente pedido e o IL15Ra (um domínio Sushi) ou uma variante do mesmo. A molécula de IL-2 modificada e/ou o heterodímero de proteína que inclui a IL-2 modificada reduz (ou reduzem) significativamente uma afinidade de IL2Ra para reduzir amplamente seus efeitos colaterais em tratamento clínico e é um fármaco candidato promissor.
Patent BR-112023005693-A2 (BR)
Title: Aplicação de um aditivo ao moldar o material de folha em uma haste incorporando um susceptor aquecível
Inventor: MATTEO BALBONI
IPC: A24F40/465
Filed: 2021-10-11
Abstract: APLICAÇÃO DE UM ADITIVO AO MOLDAR O MATERIAL DE FOLHA EM UMA HASTE INCORPORANDO UM SUSCEPTOR AQUECÍVEL. A presente invenção refere-se a um dispositivo (1) para produzir uma haste geradora de aerossol (2), que inclui um dispositivo convergente (3), um sistema de transporte (13), um guia do susceptor (15) e um tubo de dispensação de aditivo (21). O sistema de transporte é configurado para transportar o material de folha (11) através do dispositivo convergente. O guia do susceptor é configurado para guiar um susceptor (9). O guia do susceptor se estende para dentro do dispositivo convergente ao longo de uma direção axial e compreende uma abertura de saída (19) para o susceptor dentro do dispositivo convergente. O tubo de dispensação de aditivo tem uma seção de extremidade (29) que se estende dentro do dispositivo convergente em paralelo com o guia do susceptor. A seção de extremidade compreende uma abertura de dispensação (31) para distribuir um aditivo através da abertura de dispensação.
Patent BR-112023017472-A2 (BR)
Title: Processo para a preparação de um inibidor de cyp11a1 e intermediários do mesmo
Inventor: KARJALAINEN OSKARI
IPC: C07D309/40
Filed: 2022-02-28
Abstract: processo para a preparação de um inibidor de cyp11a1 e intermediários do mesmo. a presente invenção está relacionada a um processo melhorado para a preparação de inibidores de cyp11a1 estruturados em 4h-piranona, tais como 2-(isoindolin-2-ilmetil)-5-((1-(metilsulfonil)piperidin-4-il)metóxi)-4h-piran-4-ona (1a) e intermediários chave do mesmo, tais como 2-(clorometil)-5-hidróxi-4h-piran-4-ona (ii), 5-hidróxi-2-(isoindolin-2-ilmetil)-4h-piran-4-ona (iii), metanossulfonato de (1-(metilsulfonil)piperidin-4-il)metila (v?) e 4-metilbenzenossulfonato de (1-(metilsulfonil)piperidin-4-il)metila (v). os inibidores de cyp11a1 são úteis no tratamento de cânceres regulados hormonalmente, tal como câncer de próstata e câncer de mama.
Patent BR-112023018925-A2 (BR)
Title: Revestimentos antivirais e antimicrobianos e métodos dos mesmos
Inventor: BRITTON BENJAMIN
IPC: A61L2/232
Filed: 2022-03-21
Abstract: revestimentos antivirais e antimicrobianos e métodos dos mesmos. a presente revelação apresenta um método de inibição de microrganismos em uma superfície, incluindo aplicação à superfície de um polímero incluindo uma unidade de repetição, a unidade de repetição incluindo: uma porção contendo benzimidazólio; uma porção contendo imidazólio; ou qualquer combinação dos mesmos.
Patent BR-112023020587-A2 (BR)
Title: Sistema de monitoramento do motorista de um veículo com câmera de monitoramento de motorista e emissor de luz quase ir na montagem do espelho retrovisor interno
Inventor: AUSTEN C PETERSON
IPC: B60R1/02
Filed: 2022-05-11
Abstract: sistema de monitoramento do motorista de um veículo com câmera de monitoramento de motorista e emissor de luz quase ir na montagem do espelho retrovisor interno. um sistema de monitoramento de motorista veicular inclui uma montagem de espelho retrovisor interno possuindo uma câmera de monitoramento de motorista e o primeiro e o segundo elementos de emissão de luz quase infravermelha acomodados em uma parte superior do espelho. os elementos de emissão de luz são orientados na parte superior do espelho de modo que (i) um feixe de luz emitido pelo primeiro elemento de emissão de luz seja direcionado para a região do motorista de um veículo com a direção no lado esquerdo se a montagem de espelho for instalada no veículo lhd, e (ii) um feixe de luz emitido pelo segundo elemento de emissão de luz seja direcionado para a região do motorista de um veículo com a direção no lado direito se a montagem de espelho for instalada no veículo rhd. o sistema ativa e/ou opera o primeiro ou segundo elemento de emissão de luz para uma função de monitoramento de motorista em resposta à indicação de que a montagem de espelho está instalada, ou será instalada, em um veículo lhd ou em um veículo rhd.
Patent BR-112023020922-A2 (BR)
Title: Composição farmacêutica, uso da composição farmacêutica, método para tratar câncer em um paciente em necessidade do mesmo, e método para inibir o crescimento de células cancerígenas
Inventor: WANG CHUN-CHUNG
IPC: C07D203/22
Filed: 2021-04-28
Abstract: composição farmacêutica, uso da composição farmacêutica, método para tratar câncer em um paciente em necessidade do mesmo, e método para inibir o crescimento de células cancerígenas. uma composição farmacêutica, incluindo um composto 1-(3-(3-n,n-dimetilaminocarbonil)fenoxil-4-mtrofenil)-1-etil-n,n'-bis(etileno)fosforamidato e pelo menos um agente terapêutico incluindo um agente quimioterapêutico ou agente biológico, e seu uso médico são fornecidos.
Patent SK-2797-A3 (SK)
Title: Pyrido£3,2,1-i,j|£3,1|benzoxazine derivatives, method of producing same and pharmaceutical composition containing these substances and their use in drugs
Inventor: HALLENBACH WERNER
IPC: C07D498/06
Filed: 1995-06-28
Abstract: PCT No. PCT/EP95/02510 Sec. 371 Date Jan. 3, 1997 Sec. 102(e) Date Jan. 3, 1997 PCT Filed Jun. 28, 1995 PCT Pub. No. WO96/01829 PCT Pub. Date Jan. 25, 1996Disclosed are pyrido[3,2,1-i,j][3,1]benzoxazine compounds of the formula (I):    <IMAGE>  (I)  wherein z represents a radical having the formula:, -O- or a direct bond; and the other variables in formula (I) and Z are as described herein. The compounds have antibacterial properties and also disclosed are antibacterial compositions containing them and methods of using them to prevent or combat bacterial infections. Methods for preparing the compounds are also disclosed.
Patent CZ-68198-A3 (CZ)
Title: Battery charge state tester
Inventor: LIN LIFUN
IPC: H01M10/0568
Filed: 1996-08-08
Abstract: A condition indicator assembly (tester) for determining the condition of a main cell, e.g. a battery, is disclosed. The condition indicator assembly may comprise an electrochemical indicator cell connected in series to a auxiliary cell. The indicator cell and auxiliary cell each have an anode, cathode and electromotive force (e.m.f.) of its own. The condition indicator assembly may be permanently connected in parallel to the terminals of a main cell being tested. The condition indicator assembly is thin enough that it may be interated into a label for the main cell. As the main cell discharges, the indicator cell anode clears proportionally to the discharge of one of the electrodes of the main cell to provide a continuous visually discernible indication of the state of charge of the main cell.
Patent SK-76295-A3 (SK)
Title: Aminomethylindans, - benzofuranes and - benzothiophenes and their use
Inventor: PERREGAARD JENS K
IPC: C07C311/05
Filed: 1993-12-08
Abstract: Compounds of formula I    <IMAGE>  I  wherein R1=(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2=H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5=H, halo, alkyl, alkoxy, etc.; R6,R7=H, alkyl; R6R7=atoms to complete a ring; R8,R9=groups cited for R2, 2-oxoimidazolidinoalkyl, etc.; NR8R9=heterocyclyl; 1 of X,Y=CH2 and the other=CH2, O, S were prepd. Thus, 1-indancarboxylic acid was converted in 5 steps to 1-(N,N-dipropylaminomethyl)-6-formylaminoindane oxalate which had ED50 of 0.0055.mu.M/kg s.c. in the 8-OH DPAT cue agonism test in rats.
Patent SK-97699-A3 (SK)
Title: Lard-like product and method of making the same
Inventor: BHATIA RAJNI
IPC: A23D9/00
Filed: 1998-01-19
Abstract: The invention relates to a lard-like product comprising more than 90 wt. % of fats, said fats containing 1 - 75 wt. % of lard and 25 - 99 wt. % of other fats, whereby the SAFA content of the fat blend is equal to or less than 35 wt. % and the N20 of the fat blend is from 10 or more.
Patent CZ-262192-A3 (CZ)
Inventor: STANEK LUBOMIR
IPC: B21D1/06
Filed: 1992-08-26
Abstract: Přípravek pro vyrovnání čepelí chladných zbraní při popouštění
sestává z vyrovnávací lišty (1) a upínek (7), které
jsou nasunuty z obou stran na vyrovnávací lištu (1), a které
jsou opatřeny průchozími otvory (9) pro upínací šrouby
(10) zašroubované do závitových otvorů (6) upravených ve
vyrovnávací liště (1). přičemž na protilehlých ramenech (8)
upinek (7) alespoň z jedné strany (2,3) vyrovnávací lišty
(1)jsou upraveny klínové plochy (11) pro čepel (12).
Patent CZ-366490-A3 (CZ)
Inventor: BERNAT LEOPOLD ING
IPC: F41H7/10
Filed: 1990-07-24
Abstract: Prielez je usporiadaný v podlahe vozidla (1) a pozostáva z
obvodového rámu (2), v ktorom je uložené veko (3) uzamýkatelné
dvorná uzávermi (4). Uzávěr (4) sa skládá z telesa
(23) otočné uloženého a opatřeného sklopnou manipulačnou
rukovBfou (27). Pre zdvíhánie je veko (3) opatřené
držadlom (34),
Patent CZ-579688-A3 (CZ)
Title: Method of coating glass by deposition of chemical vapors and apparatus for making the same
Inventor: BERRY RONALD FRANK
IPC: C23C16/44
Filed: 1988-08-26
Abstract: In a method and apparatus for coating flat glass by chemical vapour deposition, a stream of inert gas is induced to flow over the surface, adjacent the glass, of diverting means used to divert a flow of used coating gas away from the glass surface being coated. The stream of inert gas avoids build-up of deposits from the used coating gas on the said surface of the diverting means, and permits operation for extended periods without the need to stop and remove such deposits.
Patent CZ-100896-A3 (CZ)
Title: Water-soluble retinoids
Inventor: MAIER THOMAS
IPC: A61P17/00
Filed: 1994-09-24
Abstract: The invention relates to novel water-soluble sugar retinoids (I) and to their preparation and the use thereof as medicaments and in the cosmetic sector, wherein X is a sugar radical attached at an oxygen atom, i.e. a mono-, di- or oligosaccharide, provided that X is not a glucose- or galactose sugar residue attached at the oxygen atom in the respective 1-positions of the glucose- or galactose sugar residues.
Patent CZ-131498-A3 (CZ)
Title: Preparation containing at least sodium hydrogencarbonate, process of its preparation and use
Inventor: FOURCOT FABRICE
IPC: C01D5/00
Filed: 1996-10-31
Abstract: A new composition comprises sodium bicarbonate, sodium carbonate and ammonia in the form of ammonium salts. Also claimed is the process for its preparation and its uses. The composition contains at least 70% (more preferably 80% and especially 80 - 95%) of sodium bicarbonate, less than 30% (more preferably less than 20% and especially 5 - 15%) of sodium carbonate, and less than 1% ammonia, as NH4+, (more preferably 0.2 - 0.7%). The preferred composition also contains less than 0.1% of ammonium carbamate (more preferably 0.01 - 0.06%) and less than 10% water(more preferably 1 - 6%). The product is used in the form of a fine powder.
Patent CZ-153498-A3 (CZ)
Title: Coating of tube inner surface, process of applying thereof, two-layer half-finished product with such coating and process for producing thereof
Inventor: CHRAMENKOV STANISLAV VLADIMIRO
IPC: F16L58/10
Filed: 1998-05-18
Abstract: The present invention relates to a coating applied onto the internal surface of a pipe, wherein said coating consists of two coaxial tubular and film-type envelopes (2, 3) made of a thermoplastic polymer. The outer envelope (2) rests against the pipe (1) internal surface, while the inner envelope (3) is separated from the first by a coaxial main reinforcement layer (4) impregnated with a solidified polymeric binder. The inner envelope (3) is made in the shape of a multiple-component homogeneous system that comprises at least one polymer selected from the group of thermoplastic polymers having a relative stretching ratio of at least 200 % and a melting point of at least 100  DEG C. This homogeneous system also comprises a structural modifier of the selected polymer. The envelope (3) and the layer (4) are formed with unjoined edges in at least one place along the coating axis, wherein said edges (6, 7) are sealed together so that the envelope (3) and the layer (4) form a monolithic structure. The present invention also relates to a two-layered semi-finished part that comprises the inner envelope (3) linked to the reinforcement layer (4), wherein said envelope is obtained from the multiple-component homogeneous system having the above-mentioned composition.
Patent CZ-174093-A3 (CZ)
Title: Inserted tool of substantially parallelepipedal form for rotary milling tools
Inventor: SATRAN AMIR
IPC: B23C5/10
Filed: 1993-08-24
Abstract: A cutting insert (1) for use with a rotary milling cutter tool and having at least one major cutting edge (5) comprising first, second and third successive component cutting edges (5a, 5b, 5c), each second component cutting edge being substantially coextensive with a bore (1a) and being of substantially greater length than the length of each of said first and third component cutting edges (5a, 5c) and defining with respect to said axis of rotation of the cutter tool an axial rake angle which is substantially less positive than the axial rake angles defined respectively by said first and third component cutting edges (5a, 5c) with respect to said axis of rotation. <IMAGE>
Patent CZ-193897-A3 (CZ)
Title: Process for preparing allyl ether, allyl thioether or allylamine and process for preparing an epoxide compound
Inventor: AU ANDREW T
IPC: C07C209/68
Filed: 1995-12-19
Abstract: Epoxy-containing compounds are prepared by: (1) providing an allyl reagent; (2) allylating one or more compounds containing at least one active-hydrogen atom per molecule using the allyl reagent from step (1), whereby an allyl ether, allyl amine or allyl thioether compound is formed; and (3) converting the allyl groups on the compound from step (2) to epoxide groups, whereby a glycidyl ether, glycidyl amine or glycidyl thioether compound is formed, characterized in that the allyl reagent is an allyl carboxylate or allyl carbonate. The epoxy-containing compounds are useful in coatings, castings and laminates.
Patent CZ-9802290-A3 (CZ)
Title: Starting material for producing building material or shaped object
Inventor: HENRICH ROLF
IPC: B29C48/03
Filed: 1998-07-22
Abstract: A material for producing a building material or a shaped article comprises a melt mixture of thermoplastic with rubber. Also claimed is a method for producing the article which comprises heating the mixture to form a melt and either forming or shaping the material. Also claimed is a sheet.
Patent CZ-234196-A3 (CZ)
Title: Sealing device against medium affects
Inventor: WAMBEKE ALAIN
IPC: H02G15/013
Filed: 1995-02-24
Abstract: PCT No. PCT/GB95/00383 Sec. 371 Date Dec. 2, 1996 Sec. 102(e) Date Dec. 2, 1996 PCT Filed Feb. 24, 1995 PCT Pub. No. WO95/23448 PCT Pub. Date Aug. 31, 1995A device capable of co-operating with an outer pressure member to form a sealing block between two or more elongate substrates and a hollow housing within which the substrates extend, the device comprising i) an elongate support member and ii) two or more elongate flexible leaves each of which comprises a sealing material that (a) is not heat fusible, (b) is secured relative to the support member, and (c) extends laterally of the elongate support member, the device being positioned, in use, between the elongate substrates, so that a first of the flexible leaves extends at least part of the way around the periphery of a first of the elongate substrates, and a second of the flexible leaves extends at least part of the way around the periphery of a second of the elongate substrates, so that in co-operation with the action of the outer pressure member acting inwardly on the substrates and the device, and outwardly onto the housing, a sealing block is made between the elongate substrates and the housing.
Patent CZ-282096-A3 (CZ)
Title: Thiazolidines and oxazolidines substituted by pyridine ring and their application as hypoglycaemic agents
Inventor: OHARA YOSHIO
IPC: C07D417/14
Filed: 1995-03-27
Abstract: The present invention provides novel pyridine type thiazolidines and their salts, expressed by formula (I) (wherein X<1> is S or O; X<2> is S, O or NH; Y is CR<6>R<7>, R<6> is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group, and R<7> is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group or forms a bond together with R<4>), or SO2; Z is a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, a C3-C7 cycloalkyl group, a C3-C7 cycloalkenyl group (each of said alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups may be substituted with at most 3 of hydroxyl, oxo, C1-C7 alkyl and C1-C7 alkoxy groups), a phenyl group, a biphenyl group, an  alpha -naphthyl group, a  beta -napthyl group, a benzyl group or a heterocyclic group. The compounds have a hypoglycemic effect.
Patent CZ-330297-A3 (CZ)
Title: Therapy employing arteriovenous and venous grafts, methods and preparations
Inventor: ZALEWSKI ANDREW
IPC: A61P29/00
Filed: 1996-04-19
Abstract: A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
Patent CZ-351098-A3 (CZ)
Title: Local preparation for supplying skin active agents into skin, treatment method, cleaning and lightening of skin and method of reducing size of pores
Inventor: ALBACARYS LOURDES DESSUS
IPC: A61K8/46
Filed: 1997-04-25
Abstract: Disclosed are topical skin care compositions which comprise from about 0.1 % to about 20 % by weight of an amine oxide surfactant, from about 0.1 % to about 20 % by weight of an anionic surfactant, from about 0.001 % to about 20 % by weight of a skin active agent, from about 40 % to about 99 % by weight of water, and dispersed surfactant complex formed prior to or during formulation of the composition, which complex comprises from about 25 % to about 100 % of the cationic surfactant of the composition and from about 25 % to about 100 % of the anionic surfactant of the composition. The skin care compositions are useful for clarifying the skin and reducing pore size, while providing improved deposition or efficacy of skin active agents onto the surface of the skin, milder cleansing of the skin, and improved skin feel benefits.
Patent CZ-9904062-A3 (CZ)
Inventor: PLAK ANDRZEJ
IPC: F25D23/06
Filed: 1999-11-17
Abstract: Zpevněné zařízeni na chlazení tekutin ve tvaru sudu je tvořeno
obloukovými segmenty (6). vytvářejícími boční povrch sudu a
navzájem spojenými obručí (4). Boční pov reh sudu je tvořen
jednak dílčími obloukovými segmenty (6), uchycenými
v obručích (4) a obloukovými segmenty (I) uchycenými
rovněž v obručích (4) a navíc spojenými spojovacími prvky
(7) s alespoň jedním, s výhodou dvěma obručovými segmenty
15). Obloukové segmenty (T) spojené obručovými segmenty
(5) jsou opatřeny otvory (8). vytvořenými u jednoho dna
sudu, výhodně v jedné rov ině. K dílčím obloukovým
segmentům (6) jsou uchyceny čelní podpěry (9). spojené
výztuhami (10). současně připevněnými k obloukovým
segmentům (1).
Patent ES-198119-A3 (ES)
Title: UN PROCEDIMIENTO PARA UNIR LáMINAS PLáSTICAS
Filed: 1951-05-25
Abstract: Un procedimiento para unir láminas plásticas que esencialmente consiste en disponer en un mecanismo de coser a base de aguja o sea similar o igual a los de coser normales un dispositivo para calentar adecuadamente la aguja sea por inducción a alta frecuencia resistencias u otro sistema apropiado sometiéndose las láminas a unir sean totalmente a base de material plástica o con soporte textil celulósico o similar impregnado de material plástico a la acción del mecanismo como si se fueran a coser pero sin hilo de ninguna clase produciendo la aguja en sus sucesivas y consecutivas perforaciones un reblandecimiento del material plástico en las zonas a unir completando la soldadura la compresión del dispositivo de presión que presentan los aludidos mecanismos de coser.
Patent ES-8504769-A3 (ES)
Title: Methoxy methoxy-di:methyl-pyridyl methyl sulphinyl benzimidazole prodn
IPC: A61K31/44
Filed: 1983-11-11
Abstract: 5-Methoxy 2-(((4-methoxy 3,5-dimethyl 2-pyridyl) methyl) sulphinyl) benzimidazole is made by (a) reacting 5-methoxy 2-mercapto benzimidazole with 2-chloromethyl 3,5-dimethyl 4-methoxy pyridine under basic conditions to obtain 5-methoxy 2-(((4-methoxy 3,5-dimethyl 2-pyridyl) methyl) thio) benzimidazole; and (b) oxidising the prod. with m-chloro perbenzoic acid to obtain the desired cpd., which is isolated by conventional methods.
Patent ES-8600887-A3 (ES)
Title: Pollen disintegration to release therapeutic components
IPC: A23L21/20
Filed: 1984-08-03
Abstract: Disintegration of pollen grains is effected by deep-freezing followed by pulverisation to microfine particle size (e.g. 10 mu m). Disintegration is achieved without altering the structure of the active ingredients due to biochemical reactions or degradation. The prods. contg. proteins, DNA, starch, sugars, fats, carotinoids, auxins, folic acid, etc. can be used as oral tonics and medicaments.
Patent ES-8801314-A3 (ES)
Title: New peptide prepn.
IPC: C07K5/08
Filed: 1986-06-12
Abstract: New peptides of formula (I), in which A is H, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy, R is a gp. of formula (III) or (IV), X is S or (CH2)n, and n is 1 or 2, for use in pharmaceutical compsns. are made by reaction of an opt. protected cpd. of formula (II) with an opt. protected cpd. of formula R-OH in a solvent, e.g. DMF, at -30 to0 deg. C for 2-24 hrs.
Patent SK-130893-A3 (SK)
Title: Pyrrole derivatives, method of their preparation and their pharmaceutical use
Inventor: SEVRIN MIREILLE
IPC: A61P3/04
Filed: 1993-11-23
Abstract: Pyrrole derivatives of general formula (I) <IMAGE>  in which   R1 denotes a hydrogen or halogen atom, a linear or branched C1-6 alkyl group, a C3-6 alkenyl group, a C1-4 alkoxymethyl group, the benzyl radical, a phenyl group optionally substituted by one or more halogen atoms or alkyl radicals, a CO2R group in which R denotes a linear or branched C1-4 alkyl radical, the phenyl radical or the benzyl radical, or a CONR'R'' group in which each of R' and R'' denotes, independently of one another, a hydrogen atom or a linear or branched C1-4 alkyl radical, R2 denotes a hydrogen or halogen atom or a linear or branched C1-4 alkyl group and R3 denotes a 4,5-dihydro-1H-imidazol-2-yl or 1H-imidazol-4-yl group,    and their salts of addition to pharmaceutically acceptable acids. Application in therapeutics.
Patent SK-230792-A3 (SK)
Title: Agent for healing of eye inflammations
Inventor: KULKARNI PRASAD S
IPC: A61K31/445
Filed: 1992-07-23
Abstract: Disclosed is a method and composition for treating ocular inflammation in a mammal in need of such treatment, including administering to the mammal an anti-inflammatory amount of rapamycin.   <IMAGE>