Patent SG-11201808401Q-A (SG)
Title: Real time monitoring of product purification
Inventor: JUNGBAUER ALOIS
IPC: G05B23/02
Filed: 2017-04-04
Abstract: Processcontrol Parametric release Process optimization Prediction of quantity, purity and potency Statistical model In-situ sensor e.g. temperature measurement Model training Engineering/mechanistic model On-line sensor e.g. UV sensor e.g. SLS On-line sensor e.g. FTIR () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/174580 Al 12 October 2017 (12.10.2017) WIPO I PCT (51) International Patent Classification: G05B 17/02 (2006.01) G05B 23/02 (2006.01) (21) International Application Number: PCT/EP2017/057986 (22) International Filing Date: 4 April 2017 (04.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16163713.7 4 April 2016 (04.04.2016) EP (71) Applicants: BOEHRINGER INGELHEIM RCV GMBH & CO KG [AT/AT]; Dr.-Boehringer-Gasse 5-11, 1121 Wien (AT). SANDOZ GMBH [AT/AT]; Biochemi- estrasse 10, 6250 Kundl (AT). (72) Inventors: JUNGBAUER, Alois; Muthgasse 18, 1190 Wien (AT). DURAUER, Astrid; Muthgasse 18, 1190 Wien (AT). WALCH, Nicole; Muthgasse 18, 1190 Wien (AT). SAUER, Dominik; Muthgasse 18, 1190 Wien (AT). SCHARL-HIRSCH, Theresa; Muthgasse 18, 1190 Wien (AT). MELCHER, Michael; Peter Jordan StraBe 82, 1190 Wien (AT). LEISCH, Friedrich; Peter Jordan StraBe 82, 1190 Wien (AT). (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi- erl Koch, European Patent Attorneys, Landsberger Strasse 98, 80339 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: REAL TIME MONITORING OF PRODUCT PURIFICATION Fig. 1 (57) : The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time. 1111111111111101110111111111110101111101110101110111111111111101111111111111110111111 W O 20 1717 / 45 80 Al