Patent SG-11201906373V-A (SG)
Title: Chemical compounds as inhibitors of interleukin-1 activity
Inventor: STAFFORD JEFFREY A
IPC: A61P31/00
Filed: 2018-01-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date Hu omits I E IDEMIM1011101101101110#011 (10) International Publication Number WO 2018/136890 Al 26 July 2018 (26.07.2018) WIPO I PCT (51) International Patent Classification: C07D 231/56 (2006.01) C07D 513/04 (2006.01) A61K 31/416 (2006.01) A61P 1/00 (2006.01) A61K 31/4162 (2006.01) A61P 5/00 (2006.01) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61K 31/424 (2006.01) A61P 11/00 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 31/429 (2006.01) A61P 13/00 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 487/04 (2006.01) A61P 17/00 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 263/52 (2006.01) A61P 25/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 265/12 (2006.01) A61P 31/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7D 498/04 (2006.01) A61P 35/00 (2006.01) CO7D 498/20 (2006.01) Published: (21) International Application Number: — with international search report (Art. 21(3)) PCT/US2018/014728 (22) International Filing Date: 22 January 2018 (22.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/449,431 23 January 2017 (23.01.2017) US 62/492,813 01 May 2017 (01.05.2017) US (71) Applicant: JECURE THERAPEUTICS, INC. [US/US]; 4757 Nexus Center Drive, Suite 150, San Diego, California 92121 (US). = (72) Inventors: STAFFORD, Jeffrey A.; 12752 Sandy Crest Court, San Diego, California 92130 (US). VEAL, James M.; 8916 Weaver Crossing Road, Apex, North Caroli- na 27502 (US). TRZOSS, Lynnie Lin; 9120 Meadownm Way, San Diego, California 92129 (US). MCBRIDE, Christopher; 10595 Montego Drive, San Diego, California 92124 (US). (74) Agent: TONG, Connie C. et al.; Cooley LLP, 1299 Penn- sylvania Avenue, NW, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 1-1 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. O cc (54) Title: CHEMICAL COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY 00 (57) : The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their O use in treating a disease or condition responsive to modulation of cytokines such as IL-1[3 and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process. C