Patent SG-11201809778T-A (SG)
Title: Dna antibody constructs for use against pseudomonas aeruginosa
Inventor: WEINER DAVID
IPC: C07K16/12
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111011111111111111 01011E10 III 011111111011111101111101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/193101 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: NGUYEN, Quang, D.; Riverside Law, LLP, Glen- A61K 39/40 (2006.01) C07K 16/12 (2006.01) hardie Corporate Center, 1285 Drummers Lane, Suite 202, C07K 16/00 (2006.01) Wayne, PA 19087 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/031449 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 05 May 2017 (05.05.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/332,363 05 May 2016 (05.05.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors; and (71) Applicants: WEINER, David [US/US]; 717 Beacom (84) Designated States (unless otherwise indicated, for every Lane, Merion, PA 19066 (US). PATEL, Ami [US/US]; 1 kind of regional protection available): ARIPO (BW, GH, Rainey Court, Philadelphia, PA 19103 (US). YAN, Man GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — [US/US]; 503 Sheffield Drive, Wallingford, PA 19086 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = _ _ (54) Title: DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA = A = = = oni L, » li.dvy Liog Chain Chain .. , .. Optimization and = Bisi., it, SW111011r:P optina7ation mutt ,.. i into DNA — 1,4,R bt/ftt Chain = t.nctional IgG = = .... tA ' = 14t Exp fes s i o . A qcrarnhly A Secretion = 11131111114 IgGi = < = +.. = D b enters systemic 'isolation; binds to Pseudornones aeruyinose 11 15 % 1\" 1-1 V 0 1-1 01 en 1-1 Figure 1A ---- (57) : Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed IN ,1 herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also 0 provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method \" of generation. [Continued on next page] WO 2017/193101 Al MIDEDIMOIMMIIMMEMOMEMIOMMIRHIMEMOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))