Patent SG-11201810018T-A (SG)
Title: Phosphoramidate nucleoside derivatives as anticancer agents
Inventor: GRIFFITH HUGH
IPC: C07H19/173
Filed: 2017-05-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 DOI 010111110101111 0 011111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/207986 Al 07 December 2017 (07.12.2017) W I PO I PCT (51) International Patent Classification: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, C07H 19/173 (2006.01) A61P 35/00 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, A61K 31/7076 (2006.01) A61P 35/02 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, C07H 19/207 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/GB2017/051549 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 31 May 2017 (31.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 1609601.8 01 June 2016 (01.06.2016) GB Published: (71) Applicant: NUCANA BIOMED LIMITED [GB/GB]; 10 Lochside Place, Edinburgh Scotland EH12 9RG (GB). — with international search report (Art. 21(3)) (72) Inventors: GRIFFITH, Hugh; c/o NuCana BioMed Lim- ited, PO Box 10, Lochside Place, Edinburgh Scotland EH12 _ 9RG (GB). SERPI, Michaela; c/o School of Pharmacy & Pharmaceutical Sciences, Cardiff University„ Redwood — Building, King Edward VII Avenue, Cardiff South Glam- organ CF10 3NB (GB). SLUSARCZYK, Magdalena; c/ = - o School of Pharmacy & Pharmaceutical Sciences, Cardiff =_ University, Redwood Building, King Edward VII Avenue, Cardiff South Glamorgan CF10 3NB (GB). = (72) Inventor: MCGUIGAN, Christopher (deceased). (74) Agent: HGF LIMITED; 1 City Walk, Leeds West York- shire LS11 9DX (GB). (81) Designated States (unless otherwise indicated, for every = = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = = = = = = = = (54) Title: PHOSPHORAMIDATE NUCLEOSIDE DERIVATIVES AS ANTICANCER AGENTS = (57) : This invention relates to derivatives of cladribine of Formu- RIR. _ _ = la (I). The compounds are phosphoramidate derivatives in which the phos- phoramidate moiety is situated on the 3'-hydroxyl group of cladribine. The _ invention also relates to pharmaceutical formulations of the cladribine de- rivatives and their use in methods of treatment. The compounds are useful 1-1 in the treatment of cancer. GC 0\ IN R 0 0 ei IN 1-1 OR' 0 ei 0) C