baber/WOPTO huggingface dataset:
Patent EP-2202312-A2 (EP)
Inventor: BRANDIS JOHN
IPC: C12Q1/6869
Filed: 1998-03-12
Abstract: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction region is located at portions of the O-helix, (ii) the K-helix, and (iii) the inter O-P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases. In addition to providing novel mutant DNA polymerases, the invention also provides polynucleotides encoding the subject mutant DNA polymerases. The polynucleotides provided may comprise expression vectors for the recombinant production of the mutant polymerases. The invention also provides host cells containing the subject polynucleotides. The invention also includes numerous methods of using the subject DNA polymerases, including uses for chain termination sequencing and PCR. Another aspect of the invention is to provide kits for synthesizing fluorescently labeled polynucleotides in accordance with the methods of the invention. Kits of the invention comprise a mutant DNA polymerase of the invention and a fluorescently labeled nucleotide that exhibits reduced discrimination with respect to the mutant DNA polymerase in the kit.
Patent EP-2161118-A2 (EP)
Inventor: CHATEL ROBERT EDOUARD
IPC: B29C48/40
Filed: 2009-08-27
Abstract: An extrusion die (100) for extruding cooked dough includes at least one slot having an inlet edge (10), an outlet edge (20) and a land (30). The land (30) has a length (L L ) and a depth (D L ), with the depth (D L ) extending between the inlet and the outlet edges and the length extending between a first side (32) and a second side (36) of the land. The depth of the land varies along at least a portion of the length. An extruder and a process for forming cereal flakes using the extrusion die includes the steps of extruding and cutting.
Patent EP-2143661-A2 (EP)
Inventor: YERBY PATRICK TIMOTHY
IPC: B65D83/22
Filed: 2004-03-03
Abstract: The present invention comprises an improved actuator (210) for actuating an aersol valve (220) for dispensing an aerosol product (211) from an aerosol container (240), comprising: a base (260) having an outer ring (280) and an inner ring (284) defined about an axis of symmetry of said base (260) forming an annular void (292) therebetween; a mounting (266) for securing said base (260) to the aerosol container (240); a unitary actuator button (270) comprising a rigid sidewall (273) supporting a rigid top actuating surface (276); a nozzle (310) defining a nozzle channel (312) extending between the aerosol valve (220) and a terminal orifice (316); said nozzle (310) being mounted to said unitary actuator button (270) for enabling said nozzle to pivot for actuating the aerosol valve (220); said actuator button (270) being rotatable about said axis of symmetry of said base (260) between a locked rotational position and an unlocked rotational position; said unitary actuator button (270) being movable within said annular void (292) between said outer ring and said inner ring of said base pivoting said nozzle (310) to actuate the aerosol valve (220) for dispensing aerosol product (211) from said terminal orifice (316) when said actuator button (270) is in said unlocked rotational position; and said unitary actuator button (270) being inhibited from pivoting said nozzle (310) when said actuator button (270) is rotated into said locked rotational position.
Patent EP-2199111-A2 (EP)
Inventor: KAGEYAMA NAOKI
IPC: B60C11/03
Filed: 2009-11-20
Abstract: A pneumatic tire whose steering stability on dry roads is improved with minimizing lowering of on-snow performances and which has round shoulders and comprises tread portion (2) divided by circumferential main grooves (3) and lateral grooves (4) into blocks (5) provided with sipes (6) each having zigzag part (8), the circumferential grooves (3) including at least a pair of axially outermost circumferential grooves (3o) to divide the tread portion (2) into shoulder regions (Ysh) and crown region (Ycr), wherein the zigzag part (8) of sipes (6sh) disposed in the shoulder regions (Ysh) has a larger zigzag amplitude (Wsh) and a larger zigzag pitch (Psh) than zigzag amplitude (Wcr) and zigzag pitch (Pcr) of the zigzag part (8) of sipes (6cr) disposed in the crown region (Ycr), and angle (θsh) of the sipes (6sh) with respect to the axial direction is smaller than angle (θcr) of the sipes (6cr) with respect to the axial direction.
Patent EP-2177223-A2 (EP)
Inventor: BLANCHARD JULIE
IPC: A61P35/02
Filed: 2002-09-05
Abstract: The present invention concerns a method of treating chronic myelogenous leukemia, a related myeloproliferative disorder or a Ph-positive acute lymphocytic leukemia in a subject animal, comprising: 
(a) selecting or identifying an animal suffering from chronic myelogenous leukemia or a related myeloproliferative disorder and showing resistance or intolerance to treatment with STI571; and 
(b) administering to the animal homoharringtonine. 
     In a preferred embodiment, the animal is a human being.
Patent EP-2154740-A2 (EP)
Inventor: COLSON THOMAS
IPC: H01M10/6567
Filed: 2006-05-12
Abstract: A system and method mounts batteries in a substrate or insert to a substrate, electrically connects them via a set of conductors, and cools them using air, or cooling tubes having a flow of air or coolant running in opposite directions past each of the batteries.
Patent EP-2149695-A2 (EP)
Inventor: BAKER NIGEL
IPC: F02D41/20
Filed: 2003-09-23
Abstract: A method of controlling a drive circuit (20a, 20b, 20c) for an injector arrangement including at least one injector (12; 12a, 12b) having capacitive-like properties, the drive circuit including at least one inductor (L1; L11; L21; L22) and a bidirectional current path (26) coupled to the at least one injector; selector means (Q13, Q14, Q23, Q24) for selecting one of the at least one injector(s) (12; 12a, 12b); and switching means for controlling current flow through the at least one injector (12; 12a, 12b) and the at least one inductor (L1; L11; L21; L22) to open and close the at least one injector, wherein the switching means includes a discharge switch means controllable to cause a charging current (I CHARGE ) to flow through the bidirectional current path (26) during a charge mode so as to charge the at least one injector, and discharge switch means (Q2; Q12; Q22) to cause a discharge current (I DISCHARGE ) to flow through the bidirectional current path (26) during a discharge mode so as to discharge the at least one injector. The method comprises selecting an injector (12; 12a, 12b) to permit a discharging current to be supplied thereto so as to initiate an injection event; activating the discharge switch means (Q2; Q12; Q22) to supply the discharging current to the selected injector until the voltage across the selected injector reaches a predetermined discharge level (V discharge ); and enabling the discharge switch means (Q2; Q12; Q22) for a time period (t1) after the predetermined discharge level (V discharge ) has been reached thereby reducing voltage ringing in the drive circuit.
Patent EP-2320121-A2 (EP)
Inventor: YANG YOUNG MYUNG
IPC: F17C1/08
Filed: 2009-11-24
Abstract: The present disclosure relates to a unit-wall structure (10) for a liquefied gas storage tank on land, which enables rapid and easy construction of a cylindrical wall of the storage tank by stacking a plurality of pre-produced unit-wall structures to overlap one another. The unit-wall structure (10) includes iron rods (11) arranged lengthwise and breadthwise therein, wherein the unit-wall structure has an arc shape so that a plurality of unit-wall structures are stacked to form a cylindrical wall of the storage tank.
Patent EP-2087846-A2 (EP)
Inventor: SMITH ROBERT C
IPC: A61B17/34
Filed: 2009-01-12
Abstract: A surgical portal apparatus (2) includes a portal member (10) dimensioned to access tissue and having a longitudinal passageway therethrough to permit access to underlying tissue, and defining leading and trailing ends (12,14), a seal housing (20) associated with the portal member (10) and a seal mount (30) at least partially disposed within the seal housing (20). The seal mount (30) is adapted for rotational movement within the seal housing (20). The seal mount (30) includes an instrument seal (36) adapted to establish a substantial sealed relation with a surgical object introduced within the longitudinal passageway and a closure valve (40) adapted to substantially close the longitudinal passageway in the absence of the object.
Patent EP-2105579-A2 (EP)
Inventor: BACKHOUSE ROBERT CHARLES
IPC: F01D5/28
Filed: 2009-02-12
Abstract: An article such as a fan blade of a turbofan engine comprises a core 2 made up of components 4, 6 at least some of which comprise packs of rods 8 embedded in a resin matrix material. The rods 8 extend in the span-wise direction of the blade to resist centrifugal forces imposed on the blade during operation. The core 2 is encased in a skin formed from preforms 16, 18, which may comprise fabric reinforcements.
Patent EP-2131480-A2 (EP)
Inventor: HARKE MICHAEL
IPC: H02M7/217
Filed: 2009-06-03
Abstract: A controller (16) for a multi-level converter (10) regulates the DC midpoint voltage of the multi-level converter by accounting for the effect non-redundant switch states have on the DC midpoint current. The controller includes a DC bus regulator (18) that monitors the DC output voltage and generates in response a commanded voltage vector. A duty cycle calculator (22) is operably connected to receive the commanded voltage vector generated by the DC bus regulator and to generate in response to the commanded voltage vector duty cycles associated with non-redundant switch states. A DC midpoint regulator (20) is operably connected to receive the non-redundant duty cycles calculated by the duty cycle calculator and to generate in response a first midpoint current command that accounts for the effect the non-redundant switch states have on the midpoint current. Based, at least in part, on the calculated effect the non-redundant switch states will have on the midpoint current, the DC midpoint regulator regulates the DC midpoint voltage of the multi-level rectifier to a desired value.
Patent EP-2166195-A2 (EP)
Inventor: DICKIE PAUL A
IPC: F01D25/18
Filed: 2009-09-17
Abstract: An assembly includes a reservoir (12) for holding a fluid, and a scavenge passage (24) connected to the reservoir (12) at a reservoir inlet (14). The scavenge passage (24) returns the fluid from a delivery location to the reservoir (12). A bleed passage (40) is connected in fluid communication between the reservoir (12) and the scavenge passage (24).
Patent EP-2209146-A2 (EP)
Inventor: BENWADIH MOHAMED
IPC: H01L51/10
Filed: 2009-11-27
Abstract: The transistor has a semi-conductor material (50) connecting a source (4) to a drain (3). A gate (1) and an insulating layer (2) surround an assembly constituted by the source, the drain and the semi-conductor material. The insulating layer is arranged between the gate and the assembly. The drain and the source are constituted by first and second electrical conductors respectively, arranged in a parallel manner and disconnected, one from the other. The conductors are surrounded by a layer of the semi-conductor material over their entire circumference and on a part of their length.
Patent EP-2151525-A2 (EP)
Inventor: ELCOSO CEREZUELA GONZALO
IPC: A01G25/06
Filed: 2009-08-05
Abstract: The invention relates to a device for installing underground irrigation conduits and a process for connecting parts in irrigation conduits. The device of the invention incorporates a platform (16), in which there is defined an elongated service passage (17), with dimensions slightly greater than those of the tractor vehicle (36) to which it is fixed, parallel to which platform there is established a longitudinal guide (19) on which the connecting machine (20) for connecting parts in conduits is movable, and which is finished at its rear end in a second flexible guide (39), for feeding the actual apparatus (1) for installing underground irrigation conduits, with the particularity that in correspondence with the front end of the platform there is established an arm (37) on which a reel (38) for supplying the irrigation conduit (23) to be buried in the ground to the connecting machine (20) for connecting parts in conduits is arranged through the corresponding bearings or bushes.
Patent EP-2245174-A2 (EP)
Title: Compositions améliorées de réactifs destinées à être utilisées dans la détection électrochimique
Inventor: BELL DOUGLAS E
IPC: C12Q1/00
Filed: 2009-01-16
Abstract: L'invention porte sur des compositions de réactifs biologiques, destinées à être utilisées dans des systèmes et procédés de mesure, qui présentent une sensibilité améliorée à la concentration de glucose dans le sang dans des prélèvements de patients. Les compositions de réactifs comportent une enzyme glucose oxydoréductase, une coenzyme flavine nucléoside et une formulation de médiateur. La formulation de médiateur comporte au moins une molécule organique électro-active et au moins un complexe de coordination.
Patent EP-2247362-A2 (EP)
Inventor: MUENKEL KARLHEINZ
IPC: B01D46/00
Filed: 2009-02-26
Abstract: Filtre à air doté d'un pré-dépoussiéreur présentant une géométrie d'écoulement optimisée, la géométrie d'écoulement du pré-dépoussiéreur correspondant à la géométrie d'écoulement d'un élément filtrant.
Patent EP-2288353-A2 (EP)
Title: Méthode permettant de traiter une douleur aiguë au moyen d'une forme retard d'une préparation combinée avec une préparation liquide
Inventor: ZANELLA JOHN MYERS
IPC: A61P29/00
Filed: 2009-04-17
Abstract: L'invention concerne des méthodes efficaces permettant de traiter la douleur. L'injection d'une préparation liquide contenant un principe actif suivie de l'administration d'une forme retard contenant un principe actif au niveau ou à proximité d'un site cible permet de traiter efficacement une douleur. Ce mode de réalisation est particulièrement efficace pour traiter une douleur radiculaire aiguë.
Patent EP-2271954-A2 (EP)
Title: Système et procédé d'interprétation de données de puits
Inventor: WILKINSON DAVID A
IPC: G01V11/00
Filed: 2009-04-24
Abstract: Selon l'invention, des données de journal de puits se voient attribuer des étiquettes sédimentaires par un procédé de calcul souple. Un modèle est appris sur un journal de puits interprété par un expert par segmentation, attribution de symboles flous aux segments et calcul de valeurs d'attribut pour des unités étiquetées par l'expert. A partir de ces valeurs, des classificateurs sont appris pour chacun d'un certain nombre de types sédimentaires. Enfin, un modèle est développé pour traduire des symboles flous en étiquettes sédimentaires. Une fois appris, le modèle est appliqué à des données de journal de puits.
Patent EP-2288373-A2 (EP)
Title: Traitement de la dyspnoé associée avec l'insuffisance cardiaque aiguë avec la relaxine
Inventor: UNEMORI ELAINE
IPC: C07K14/64
Filed: 2009-05-15
Abstract: L'invention concerne des méthodes permettant de réduire une décompensation par une intervention à chaud, notamment chez des sujets atteints d'une défaillance cardiaque aiguë décompensée. En particulier, ces méthodes permettent de traiter une décompensation cardiaque aiguë par l'administration d'une dose efficace au plan pharmaceutique de relaxine.
Patent EP-2297313-A2 (EP)
Inventor: CHIN REGINA
IPC: C12N9/26
Filed: 2009-06-05
Abstract: Alpha amylases from  Bacillus subtilis  (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof are disclosed, including liquefaction and/or saccharification of starch. Such methods may yield sugars useful for ethanol production or high fructose corn syrup production. In some cases, the amylases can be used at low pH, in the absence of calcium, and/or in the absence of a glucoamylase.
Patent EP-2297358-A2 (EP)
Inventor: RESHATOFF MICHAEL R
IPC: C12Q1/68
Filed: 2009-05-29
Abstract: Provided are compositions, kits, and methods for the identification of Salmonella. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.
Patent EP-2297131-A2 (EP)
Inventor: CHESWORTH RICHARD
IPC: A61K31/47
Filed: 2009-06-25
Abstract: Di-substituted phenyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. The disclosure also relates to methods for treating neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
Patent EP-2331658-A2 (EP)
Inventor: GOSS DAVID HENRY
IPC: C10L10/02
Filed: 2009-07-31
Abstract: Described herein are modified fuels with improved properties. The modified fuels are more efficient when compared to conventional fuels such as gasoline. Additionally, the modified fuels bum more efficiently and produce fewer emissions. Finally, the modified fuels also do not require any modifications to existing engines.
Patent EP-2331075-A2 (EP)
Title: Formulations de peptide à libération contrôlée
Inventor: BURTON KEVIN
IPC: A61K9/16
Filed: 2009-08-28
Abstract: La présente invention a pour objet des procédés et des compositions pour moduler les caractéristiques de libération et/ou de charge en médicament d’agents bioactifs encapsulés dans des systèmes d’administration à base de polymère par l’intermédiaire d’une modification directe du point isoélectrique et/ou de la charge nette de l’agent bioactif.
Patent EP-2370077-A2 (EP)
Title: Procédé de traitement d'une dégénérescence maculaire
Inventor: HAHN CHANG S
IPC: A61K31/4985
Filed: 2009-12-18
Abstract: L'invention porte sur des procédés nouveaux et utiles pour prévenir, traiter ou améliorer une dégénérescence maculaire telle qu'une dégénérescence maculaire sèche, une dégénérescence maculaire humide et une dégénérescence maculaire liée à l'âge chez un patient.
Patent EP-2328986-A2 (EP)
Inventor: LI DONGHONG
IPC: C09D191/00
Filed: 2009-07-16
Abstract: A glaze composition for application to a substrate includes a dry powder latex, a liquid latex emulsion, a coalescing solvent, a wax, a thickener and water The glaze is rewettable during application and is extremely durable after fully dry Optionally, the glaze also includes one or more of a surfactant, a dispersant, one or more pigments, a dispersant, a defoamer, a slow drying solvent, and a slow drying hydrocarbon resin
Patent EP-2320958-A2 (EP)
Title: Complexe électrolytique pour transmettre des propriétés antimicrobiennes à un substrat
Inventor: TOREKI WILLIAM
IPC: A61L2/16
Filed: 2009-07-20
Abstract: L'invention concerne des poly-électrolytes anioniques utilisés en tant qu'agents de liaison pour réduire la solubilité de poly-électrolytes antimicrobiens cationiques. L’attraction ionique entre les poly-électrolytes de stabilisation anioniques et les poly-électrolytes cationiques antimicrobiens a pour résultat la formation d'un complexe électrolytique (PEC). Un liquide de traitement comportant un colloïde stable, une suspension, une dispersion, une solution, un coacervat ou une émulsion du PEC dans un support aqueux, est utilisé pour traiter un support absorbant, recouvrant, infiltrant ou infusant ainsi le PEC sur ou dans le substrat. Un séchage ultérieur a pour résultat un substrat modifié qui est lié au substrat et qui est sensiblement moins sujet, par rapport aux poly-électrolytes constitutifs, d'être lavé, blanchi, de fuir, d'être extrait ou de migrer depuis le substrat en utilisation, ou lors d'une exposition à des fluides ou à des solvants aqueux. Le substrat modifié peut en outre être traité avec de l'oxyde d'éthylène qui améliore son efficacité antimicrobienne, sa biocompatibilité, et son utilité dans des pansements, des dispositifs médicaux, des vêtements, etc.
Patent EP-2328877-A2 (EP)
Title: Composés de 1,4-benzoxazine, et dérivés de ceux-ci en tant que médicaments thérapeutiques pour le traitement de troubles neurodégénératifs
Inventor: D MELLO SANTOSH R
IPC: C07D265/36
Filed: 2009-08-14
Abstract: L'invention concerne des compositions et procédés pour inhiber une activité kinase afin de protéger à l'encontre d'une neurodégénération, y compris des maladies comme la maladie d'Alzheimer, la maladie de Parkinson, ou la maladie d'Huntington, et des états comme un accident ischémique, comprenant l'étape consistant à fournir au sujet une quantité thérapeutiquement efficace de composés de 1,4-benzoxazine, et de dérivés de ceux-ci.
Patent EP-2331154-A2 (EP)
Inventor: HENG BOON CHIN ALEXIS
IPC: A61M25/00
Filed: 2009-09-02
Abstract: La présente invention porte sur des produits de construction comprenant des cellules vivantes, de préférence des cellules souches, qui ont été enrobés d’une ou plusieurs couches de polyélectrolytes de charge alternée, et dont la couche la plus externe comporte des nanoparticules électrostatiquement conjuguées portant un ou plusieurs agents thérapeutiques. L'invention concerne en outre l'utilisation des produits de construction pour traiter un infarctus du myocarde.
Patent EP-2327271-A2 (EP)
Title: Sontheque et procede associe
Inventor: GOLDSTEIN STEVEN
IPC: G10L25/54
Filed: 2009-09-16
Abstract: Au moins un mode de réalisation, à titre d'exemple, de l'invention concerne un site web destiné à recueillir des signatures sonores provenant du monde et au-delà. Un dispositif de communication stocke automatiquement les informations acoustiques reçues par un microphone du dispositif de communication. Lesdites informations acoustiques sont analysées à la recherche d'un évènement déclencheur. Ledit évènement déclencheur stocke les informations acoustiques, joint des métadonnées, crée un modèle de mélange gaussien et mesure le niveau de pression sonore. Le dispositif de communication envoie automatiquement la signature sonore à une base de données lorsqu'un chemin de communication lui est ouvert. Chaque signature sonore possède des métadonnées associées comportant une référence temporelle et un géocode. Le recueil automatique de sons au moyen d'un dispositif de communication conçu pour ce procédé, permet à une base de données de capturer des sons de manière globale sur une base continue.
Patent EP-2256285-A2 (EP)
Inventor: DERRER SIEGFRIED
IPC: E21B3/02
Filed: 2010-02-12
Abstract: The arrangement has a bearing (5) arranged between a base body and a support for rotating a drilling rod around axis (6) relative to the base body with a drive unit. The bearing is provided with a bearing inner ring (7) and bearing outer rings (8', 8''). Running paths (9 ', 9'', 9 ''', 10', 10'', 10''') are incorporated in the bearing inner ring and the bearing outer rings. Roller bodies (11, 12, 13) are arranged between the running paths, where one of the roller bodies is designed as a spherical roller or pendulum roller.
Patent EP-2246965-A2 (EP)
Inventor: PILICHIEWICZ MAREK
IPC: H02K15/00
Filed: 2010-03-31
Abstract: The method involves removing the old coils and replacing the old coils by new coils such that one-piece half-windings of a section parallel to a rotor axis (2) and of two arc-shaped sections in the area of two coil ends (5) are used. The arc-shaped sections of the coils are reduced with respect to their profile width by material degradation with a part of the windings or with all windings.