Patent SG-11201809527U-A (SG)
Title: Methods of treating circadian rhythm sleep disorders
Inventor: BEUCKMANN CARSTEN
IPC: A61P43/00
Filed: 2017-05-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111011111011H1101111001111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/197160 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: Margaret [US/US]; 18 Eastdale Road, White Plains, NY A61K 31/501 (2006.01) A61P 25/28 (2006.01) 10605 (US). SATLIN, Andrew [US/US]; 350 Long Hill A61P 43/00 (2006.01) Drive, Short Hills, NJ 07078 (US). (21) International Application Number: (74) Agent: MACALPINE, Jill, K.; Finnegan, Henderson, PCT/US2017/032228 Farabow, Garrett & Dunner, LLP, 901 New York Avenue, (22) International Filing Date: NW, Washington, DC 20001 (US). 11 May 2017 (11.05.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/335,599 12 May 2016 (12.05.2016) US HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 62/335,611 12 May 2016 (12.05.2016) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/413,976 27 October 2016 (27.10.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/414,599 28 October 2016 (28.10.2016) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/414,606 28 October 2016 (28.10.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. (84) Designated States (unless otherwise indicated, for every _ [JP/JP]; 6-10 Koishikawa, 4-chome, Bunkyo-ku, Tokyo, kind of regional protection available): ARIPO (BW, GH, 112-8088 (JP). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Inventors; and UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = (72) (71) Applicants: BEUCKMANN, Carsten, T. [DE/JP]; 5-1-3 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Tokodai, Tsukuba, Ibaraki, 300-2635 (JP). MOLINE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = = = (54) Title: METHODS OF TREATING CIRCADIAN RHYTHM SLEEP DISORDERS = FIG. 'IA = = 80 = Ti ter 70 =W a kefulness = 60 o RI vehicle = 4 1 4, 9 60 ...e x.. = in RI 3 mg/kg = 0 40 E --- 30 . / // 7 a RI 30 mg/kg to P8 vehicle _ _ ,,,i) = .4 20 EPS 3 mg/kg 10 ta P8 30 mg/kg — 1-1 11\" 0.612 ZT 12-24 .4 0 1-1 Data represent least square means and standard errors IN 01 1-1 *: significant difference compared to R1 vehicle cohort (P<0.05, linear mixed model with Kenward-Roger) t: significant difference compared to P8 vehicle cohort (P<0.05, linear mixed model with Kenward-Roger) IN 1-1 0 (57) : Methods of treating irregular sleep-wake rhythm disorder in subjects and compositions for use in the same are disclosed. ei O [Continued on next page] WO 2017/197160 Al DIII MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))