Patent SG-11201407700R-A (SG)
Title: A drusen lesion image detection system
Inventor: WONG TIEN YIN
IPC: A61B3/12
Filed: 2013-06-05
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/184070 A1 (51) International Patent Classification: A61B3/12 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/SG2013/000235 5 June 2013 (05.06.2013) English English (30) Priority Data: 201204125-7 5 June 2012 (05.06.2012) SG (71) Applicants: AGENCY FOR SCIENCE, TECHNO­ LOGY AND RESEARCH [SG/SG]; Fusionopolis 1 Way, #20-10 Connexis, Singapore 138632 (SG). SINGAPORE HEALTH SERVICES PTE LTD [SG/SG]; 31 Third Hospital Avenue, #03-03 Bowyer Block, Singapore 168753 (SG). (72) Inventors: WONG, Wing Kee, Damon; c/o PKM, Insti­ tute for Infocomm Research, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). CHENG, Xiangang; c/o PKM, Institute for Infocomm Re­ search, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). LIU, Jiang; c/o PKM, In­ stitute for Infocomm Research, 1 Fusionopolis Way, #21- 01 Connexis, South Tower, Singapore 138632 (SG). TANG, Ngan Meng; c/o PKM, Institute for Infocomm Re­ search, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). LEE, Beng Hai; c/o PKM, Institute for Infocomm Research, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). YIN, Fengshou; c/o PKM, Institute for Infocomm Research, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). BHARGAVA, Mayuri; c/o PKM, Institute for Infocomm Research, Fusionopolis 1 Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). CHEUNG, Gemmy; c/o PKM, Institute for In­ focomm Research, 1 Fusionopolis Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). WONG, Tien Yin; c/o PKM, Institute for Infocomm Research, Fusionopolis 1 Way, #21-01 Connexis, South Tower, Singapore 138632 (SG). (74) Agent: WATKIN, Timothy, Lawrence, Harvey; Marks & Clerk Singapore LLP, Tanjong Pagar, P O Box 636, Singapore 910816 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, [Continued on next page] (54) Title: A DRUSEN LESION IMAGE DETECTION SYSTEM Input Retinal Image Macula detection r El / Dense sampling HWI Transform Drusen Image Recognition Dense sampling HWI Transform Drusen Image Recognition © l> o •t 00 i-H en i-H o CJ o & •asaas , 'v ' illpililll WISILM Hw (57) Abstract: A method is proposed for automatically analysing a retina image, to identify the presence of drusen which is indicat­ ive of age-related macular degeneration. The method proposes dividing a region of interest including the macula centre into patches, obtaining a local descriptor of each of the patches, reducing the dimensionality of the local descriptor by comparing the local descriptor to a tree-like clustering model and obtaining transformed data indicating the identity of the cluster. The transformed data is fed into an adaptive model which generates data indicative of the presence of drusen in the retinal image. Furthermore, the trans - formed data can be used to obtain the location of the drusen within the image. WO 2013/184070 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll lllllll llll llll llll MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Published: SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))