Patent SG-11201906765U-A (SG)
Title: Personalised immunogenic peptide identification platform
Inventor: LISZIEWICZ JULIANNA
IPC: A61K39/00
Filed: 2018-03-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT 0111111010 0111 °nolo III OH Emmo muoi IIII iflo oimIE (10) International Publication Number WO 2018/158456 Al (51) International Patent Classification: A61K 39/00 (2006.01) GO1N 33/569 (2006.01) G01N 33/50 (2006.01) A61K 39/12 (2006.01) (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17159243.9 17159242.1 1703809.2 PCT/EP2018/055231 02 March 2018 (02.03.2018) English English 03 March 2017 (03.03.2017) EP 03 March 2017 (03.03.2017) EP 09 March 2017 (09.03.2017) GB Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) cc 00 O C (71) Applicant: TREOS BIO ZRT [HU/HU]; Viola utca 2, 8200 Veszprem (HU). (72) Inventors: LISZIEWICZ, Julianna; Szorosi ut 13, 8200 Balatonalmadi (HU). MOLNAR, Levente; Kossuth Lajos u. 20., Felsopakony 2363 (HU). TOKE, Eniko, R.; Kos- suth Lajos u. 20., Felsopakony 2363 (HU). TOTH, Jozsef; Ujkut u. 72, 9012 Gyor (HU). LORINCZ, Orsolya; At- tila u. 27, fszt/13, 1047 Budapest (HU). CSISZOVSZKI, Zsolt; Attila u. 27, fszt/13, 1047 Budapest (HU). SOM- OGYI, Eszter; Borgazda u. 3, 8220 Balatonalmadi (HU). PANTYA, Katalin; Ulloi ut 16/b 2.em. 9/b, Budapest 1085 (HU). MEGYESI, Monika; Tancsics Mihaly u. 63, 3441 Mezokeresztes (HU). (74) Agent: KIMBLIN, Nicola; 14 South Square, Gray's Jim, London Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: PERSONALISED IMMUNOGENIC PEPTIDE IDENTIFICATION PLATFORM (57) : The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing personalised pharmaceutical compositions comprising such polypeptide fragments, human subject-spe- cific pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of the subject.