baber/WOPTO huggingface dataset:
Patent CA-2179886-A1 (CA)
Title: Markers of organ rejection
Inventor: HAUNS STIG
IPC: G01N33/68
Filed: 1994-12-23
Abstract: The present invention relates to the diagnosis and prognosis of organ rejection in a subject. More particularly, the invention relates to allograft rejection, e.g., heart transplant rejection. The invention provides immunological, biochemical, and molecular biological detection methods, and kits for use by medical practitioners for detecting rejection phenomena. This invention particularly concerns human proteins, or xenogeneic homologs thereof, which are predictive markers for acute allograft rejection, processes for obtaining said proteins, DNA and RNA coding for said proteins, methods of assaying biological samples from human beings for the presence, and optionally the amounts, of said proteins, an assay kit for use in said methods, polyclonal and monoclonal antibodies against each of said proteins, a method of predicting acute rejection in a human patient having undergone organ transplantation, or suffering from an autoimmune disease, inflammatory disease, or ischemic injury, and associated methods for the diagnosis of inflammation or diseases in various organ systems of the human body. In a specific example, eighteen proteins are identified as markers of heart transplant rejection by two-dimensional gel electrophoresis of biopsy samples from human patients.
Patent CA-2181542-A1 (CA)
Title: 2-(4-methoxyphenoxy)-3-pyridineamine, its preparation and its use as anti-inflammatory agent
Inventor: ALDOMA GUSTAVO ENRIQUE
IPC: C07D213/73
Filed: 1995-02-13
Abstract: The product 3-amino-2-(4-methoxyphenoxy)pyridine and its pharmaceutically suitable salts, in particular the hydrochloride, are novel products which are prepared by catalytic hydrogenation of 2-(4-methoxyphenoxy)-3-nitropyridine, optionally in the presence of the acid corresponding to the salt.  Its pharmaceutical compositions containing sufficient amounts of suitable auxiliaries for its topical administration prove particularly useful in therapy for the treatment of inflammatory skin diseases. The tests for dermatological action with the aid of TPA-induced mouse ear oedema and of carragenan-induced rat paw oedema show that the product is very much more active by the topical route than ibuprofen and nimesulide, two known anti-inflammatory active compounds, of which the first is very widely known and the second structurally related.
Patent CA-2183047-A1 (CA)
Title: Carpet extractor brush assembly
Inventor: CROUSER DARWIN S
IPC: A47L11/40
Filed: 1996-08-09
Abstract: Floor care apparatus is disclosed wherein a powered brush assembly having a multiplicity of rotary brushes is suspended within the apparatus such that the brush assembly floats freely upon the surface being cleaned without supporting any of the machine's weight. The rotary brushes are generally configured as spur gears and function in a gear train wherein one brush drives all other gear brushes in the system. Axially projecting brush bristles are embedded in each gear tooth such that there is no unbrushed area between adjacent brushes in the brush line.  The portion of the gear tooth wherein the bristles are embedded includes a recessed profile to allow for circumferential expansion of the tooth, upon insertion of the brush bristles, thereby preventing gear tooth interference. The brush assembly is particularly suitable for hot water carpet extractors of the upright design.
Patent CA-2183090-A1 (CA)
Title: Process and apparatus for sterilising surfaces
Inventor: MEZGER ULRICH
IPC: A61L2/20
Filed: 1996-08-09
Abstract: The apparatus for continuously sterilising surfaces in an aseptic filling line, comprises a feeding tube (10) for feeding a mixture of hot air and vaporised hydrogen peroxide and a plurality of nozzles (8) through which said mixture is introduced on the surfaces (9) to be sterilised, wherein the feeding tube (10) includes a section formed by a porous tube (4) for feeding directly the gaseous hydrogen peroxide (1) into the stream of hot air, said porous tube (4) being surrounded by a heated means (3).
Patent CA-2184235-A1 (CA)
Title: Splined vibration damping device using er fluids
Inventor: WEITZENHOF DAVID A
IPC: F16F9/53
Filed: 1996-08-27
Abstract: A vibration damping device for mounting between two spaced portions of a vehicle for absorbing road forces exerted on the vehicle. An inner metal cylindrical housing forms an internal piston chamber and is connected at one end to one portion of the vehicle, with the outer end of the rod of a piston which is slidably mounted within the piston chamber, being connected to the other portion of the vehicle. An outer housing surrounds a portion of the inner housing and forms a fluid transfer duct or flow channel between fluid chambers formed on opposite sides of the piston within the piston chamber. An electrode is mounted in the fluid duct for applying a voltage across the duct to affect the viscosity of an electrorheological (ER) fluid flowing therethrough to increase the damping force of the device. The electrode includes a plurality of circumferentially spaced splines and intervening grooves extending longitudinally along the fluid duct. The bottom portions of the grooves have a decreased electric field applied thereto than the splines, providing bleed grooves or leak paths for the ER fluid to decrease the shear-rate of the fluid. The inner housing may be formed with elongated projections which extend into the grooves of the electrode to provide a more uniform electric field along the fluid duct to control the amount of leakage through the bleed grooves. A secondary electrode ground may be formed in the grooves to control the electric field in the bleed grooves.
Patent CA-2184449-A1 (CA)
Title: Toe pick and skate frame for in-line skates
Inventor: PERNA NICOLAS A
IPC: A63C17/18
Filed: 1996-08-29
Abstract: A toe pick for an in-line skate provides figure skaters with a means for performing various skating maneuvers the same as performed on ice skates. The positioning and configuration of the toe pick effectively prevents the skater from over-rotating while providing a pick point used to center the skater's body in preparation for a jump or other type of stunt. The invention features a cylindrical toe pick disk held rotationally immobile by locking means, and secured to the in-line wheel frame of the skate forward of the toe wheel so as not to contact the ground during normal skating action. Although rotationally immobile, the toe pick disk is orientated to have a central axis parallel to the axis of rotation of each of the in-line skate wheels. The toe pick disk is positioned so that it contacts the horizontal skating surface, e.g., the ground, when the axis passing through the axles of the front and rear wheels of the in-line skate form an angle of between 5° and 20°. The invention also features an integral wheel frame constructed from a single piece metal extrusion machined toaccommodate boot toe and heel mounting surfaces. The integral wheel frame can beproduced in a variety of sizes by maintaining the same boot toe mounting surface and wheel and toe pick disk placement along the frame, but changing the position of the heel mounting surface.
Patent CA-2186865-A1 (CA)
Inventor: ESSIGMANN JOHN M
IPC: A61K47/48
Filed: 1995-05-04
Abstract: The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population.  The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair.  Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells.  In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired.  As a result, compounds described herein are less toxic to nonselected cells.  Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.
Patent CA-2187388-A1 (CA)
Inventor: CHRISTON PATRICIA LEE
IPC: A61L15/62
Filed: 1996-10-08
Abstract: A flushable and dispersible absorbent article is described. The absorbent article comprises a liquid pervious topsheet which preferably comprises a wet laid, apertured fibrous web having a temporary wet strength resin incorporated therein, the topsheet also having a body surface provided with a plurality of fibrils, the fibrils comprising a water resistant resinous material, a backsheet impervious to bodilyfluids which preferably comprises a wet laid fibrous assembly having a temporarywet strength resin incorporated therein, the body surface of the backsheet beingcoated with a water resistant resinous material, an absorbent core positioned between the topsheet and the backsheet, and means for removably attaching the sanitary napkin to a wearer's undergarment. The topsheet and the backsheet are joined, at least about their periphery, using a water soluble adhesive. Alternative embodiments of the present invention can also comprise laterally extending flaps.
Patent CA-2187816-A1 (CA)
Inventor: PHILIPPE MICHEL
IPC: C07C69/716
Filed: 1996-10-11
Abstract: Alkyl 3-keto-alkanoate derivatives of formula R1-CH(X)-C(O)-CH2-CO2R2 (I) are new. R1 = 6-28C alkyl, alkenyl or arylalkyl (optionally interrupted by ether bridges and optionally substituted by hydroxyl); R2 = 1-5C alkyl or alkenyl; X = leaving group.
Patent CA-2187910-A1 (CA)
Title: Apparatus and method for treating hazardous waste
Inventor: SPRINGER MARLIN D
IPC: C10J3/00
Filed: 1995-03-21
Abstract: An apparatus and method suitable for treating hazardous and non-hazardous waste materials composed of organic and inorganic components are disclosed. The apparatus includes a plasma heating system (35) and off-gas processing which converts the waste to benign solids and useful gas.
Patent CA-2189286-A1 (CA)
Inventor: TAI SHINJI
IPC: C08G63/20
Filed: 1996-10-31
Abstract: Copolyesters  consisting  essentially  of  terephthalic acid units and ethylene glycol units, and further comprising 1  to  4  mole  %  of  alicyclic  or  aliphatic  bifunctional compound  units  (a,)  or  0.5  to  7  mole  %  of bifunctional compound units (a2) derived from a specific aromatic diol or bifunctional  compound units  (a3)  derived from a condensed ring or ring assembly type aromatic dicarboxylic acid, 0.005 to 1 mole % of multi-functional compound units  (b1), and a specific  amount  of  monofunctional  compound  units   (c); copolyesters  having  a  specific  intrinsic  viscosity  and consisting  essentially  of  terephthalic  acid  units  and ethylene glycol units, and further comprising 0.5 to 7 mole % of the above bifunctional compound units (a2) and 0.005 to 1 mole % of specific multi-functional compound units (b2) or (b3); and copolyesters  consisting  essentially  of  terephthalic  acid units and ethylene glycol units, and further comprising 0.5 to 7 mole % of the above bifunctional compound units  (a3) and 0.005 to 0.5 mole % of the multi-functional compound units (b1).     These copolyesters have excellent melt moldability, in particular  extrusion  blow  moldability  and  give  molded articles having excellent transparency,  impact resistance, gelation characteristics, appearance, tactility, mechanical properties,   heat   resistance,   chemical   resistance   and dimensional precision.
Patent CA-2189996-A1 (CA)
Title: Hydrophilic pressure sensitive hot-melt adhesives
Inventor: HOFFMAN HANS-RAINER
IPC: A61K9/70
Filed: 1995-05-08
Abstract: A device for delivering substances contained in hot-melt-type pressure-sensitive adhesives with a uniform or irregular distribution of the substances is characterised in that the hot-melt-type pressure-sensitive adhesive is hydrophilic and contains at least one water-soluble or at least water-swellable polymer, at least one water-soluble, hot-melt-type adhesive resin and the substance to be delivered.
Patent CA-2191052-A1 (CA)
Title: Borate photoinitiators from polyboranes
Inventor: CUNNINGHAM ALLAN FRANCIS
IPC: G03C1/22
Filed: 1996-11-22
Abstract: Compounds of the formula I                           (I) in which n and o are a number from 0 to 50, m is a number from 1 to 50, u and v are 0 or 1, and at least one of the indices u and v is 1, R1, R2, R2a, R3 and R4 independently of one another are, for example, aromatic hydrocarbons, R5, if n and o are 0, is for example C1-C12alkyl and, if n and/or o are greater than 0, or if n and o are 0 and at the same time only one index u or v is 1, R5 may additionally, for example, be an aromatic hydrocarbon, at least one of the radicals R1, R2, R2a, R3, R4 and R5 being an aromatic hydrocarbon radical which is sterically hindered ortho to the boron atom, X is, for example, C1-C20alkylene, phenylene, biphenylene, etc., and Z is a radical which is able to form positive ions, are suitable as photoinitiators, both the compounds per se and their combination with dyes or other electron acceptors. Furthermore, the polyborane precursors of these borates possess, together with borate salts, photoinitiating properties.
Patent CA-2192936-A1 (CA)
Title: Procede et dispositif pour melanger des liquides
Inventor: BRYNING ZBIGNIEW TOMAS
IPC: B01L3/00
Filed: 1995-06-06
Abstract: La présente invention concerne des procédés et un appareil pour mélanger au moins deux liquides. Ce procédé consiste à former une gouttelette (14) de liquide contenant au moins deux liquides sur une surface sensiblement plane (12), en confinement sans récipient sur la surface, et à provoquer la déformation de cette gouttelette dans un milieu avec un écoulement d'air sensiblement nul, pour ainsi mélanger les liquides. Un appareil selon la présente invention comporte a) un support sensiblement plane (12), b) des moyens (22, 24) pour distribuer des liquides sur le support en vue de former une gouttelette, et c) des moyens non évaporatifs pour provoquer la déformation de la gouttelette sans déformation du support, pour ainsi mélanger les liquides. La gouttelette peut être déformée par exemple par application d'énergie accoustique ou d'un champ électrostatique variable. Les procédés et l'appareil décrits s'utilisent notamment pour la détermination d'un analyte.
Patent CA-2195697-A1 (CA)
Title: Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
Inventor: KITANO MASAHUMI
IPC: C07D498/06
Filed: 1997-01-22
Abstract: A substituted guanidine derivative represented by the general formula:                    (see fig. I) wherein R1, R2, R3 and R4 are independently a hydrogen atom, an unsubstituted alkyl group, a substituted alkyl group, a halogen atom or the like; Y1, Y2, Y3, Y4, Y5, Y6 and Y7, which may be the same or different, are independently a single bond, -CH2-, -O-, -CO- or the like, adjacent members of a group consisting of Y1 through Y7 being able to be taken together to represent -CH=CH-, and at least two of Y1 through Y7 being independently a group other than a single bond; Z may be absent, or one or more Zs may be present and are, the same or different, independently a substituent for a hydrogen atom bonded to any of the carbon atoms constituting the ring formed by Y1 through Y7, for example, an unsubstituted alkyl group or a substituted alkyl group, or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton (Na+/H+) exchange transport system, for example, hyperpiesia, arrhythmia, angina pectoris, hypercardia, diabetes, organopathies due to ischemia or ischemia re-perfusion, troubles due to cerebral ischemia, diseases caused by cell over-proliferations, and diseases caused by trouble with endothelial cells.
Patent CA-2196852-A1 (CA)
Title: Oxidation resistant lubricant
Inventor: RODENBERG DOUGLAS G
IPC: C10M169/04
Filed: 1997-02-05
Abstract: A synthetic lubricant composition having greatly improved oxidation resistance, compatibility with petroleum lubricants, good corrosion resistance, and hydrolytic stability, is formed by combining one or more polyalkylene glycols, singly or in combination, with an effective amount of one or more  alkylated aromatic compound such as alkylated  naphthalene. Polyalkylene glycols initiated with mono and polycyclic aromatic compounds such as alkyl phenol, cresol, and alkyl naphthol further enhance performance when used singly or in combination with other hydroxyl or alkyl initiated polyalkyene glycols. The blends are compounded with corrosion inhibitors, metal deactivators, dispersants, thickeners, and other additives known in the art of lubrication to produce a superior lubricant for air compressors, turbines, hydraulics, gears, bearings, fuel engines, textiles, textile machinery, and greases.
Patent CA-2198518-A1 (CA)
Title: Strains of bacteria and pharmaceutical composition containing such strains and use of same for preventing and treating diseases associated with or caused by alterated metabolism of bile acid
Inventor: CAVALIERE VESELY RENATA MARIA
IPC: A61K35/74
Filed: 1997-02-26
Abstract: Strains of bacteria characterized by exhibiting: (a) a 70-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition comprising one or more of such strains and useful of same for preventing and treating deseases associated with or caused by an altered metabolism of bile acids.
Patent CA-2200321-A1 (CA)
Title: Single-use device for detecting or analyzing a body fluid
Inventor: CHAFFRINGEON BERNARD
IPC: A61M31/00
Filed: 1995-09-22
Abstract: Single-use device (1) for analyzing or detecting a body fluid present in an intracorporal cavity, said device comprising an elongate sample-taking element (2) adapted to be housed and retained by simple constriction of the intracorporal cavity, with body liquid taking means (3) distributed or arranged outside the elongate element. A cap (7) complementary to the elongate element (2), detachable from the latter, comprises reaction means (8) distributed or arranged on said cap (7) and susceptible to react in a visible or perceptible way for the user with at least one component of the body liquid, the shape and size of said cap being selected so as to place in contact the sample taking means (3) with the reaction means (8), particularly during or after inserting the first means, into the second means.
Patent CA-2200993-A1 (CA)
Inventor: BAHR GEORGES
IPC: A61K38/55
Filed: 1995-09-26
Abstract: Utilisation de peptides muramyliques, notamment de Murabutide et de Muramétide, pour l'obtention de médicaments empêchant la réplication du VIH chez l'homme. Les peptides muramyliques peuvent permettre d'obtenir jusqu'à 100 % d'inhibition de la réplication rétrovirale dans des cultures monocytaires d'hôtes primaires
Patent CA-2201976-A1 (CA)
Inventor: OPREA IOAN
IPC: B62M27/02
Filed: 1997-04-07
Abstract: A vehicle for water and snow that can be used on water or snow by attaching a water device respective a snow device to a base vehicle. The base vehicle consists preferably of elements common for the water vehicle and the snow vehicle. The water device is a device that attached to the base vehicle may ensure the flotation, propulsion and direction of the vehicle on the water. By attaching the water device to the base vehicle we have a water vehicle. The snow device is preferably a combination of propulsion and direction devices that are necessary for using the vehicle on the snow. By attaching the snow device to the base vehicle we have a snow vehicle. The change in water vehicle or snow vehicle can be done easily, using simple tools, by people with minimum mechanical skills. The vehicle for water and snow is a integrated two medium, two seasonal vehicle which is the best option in areas with two main seasons, eliminating the need for two vehicles, one for water and one for snow, in the same time resulting a reduction of pollution by eliminating the off-season storage of the vehicles.
Patent CA-2202153-A1 (CA)
Title: Process for the selective separation of morpholine
Inventor: MANGENG BRUNO
IPC: D01F13/02
Filed: 1996-08-16
Abstract: The invention relates to a process for the selective separation of morpholine from an aqueous solution containing morpholine, N-methyl morpholine and N-methyl morpholine-N-oxide, in which (A) a quantity of the aqueous solution is taken through a cation exchanger capable of adsorbing morpholine until said exchanger can carry substantially no more morpholine and an eluate substantially free from morpholine but containing N-methyl morpholine and N-methyl morpholine-N-oxide is obtained, and (B) the cation exchanger charged with morpholine is regenerated and re-used in step (A).
Patent CA-2202297-A1 (CA)
Title: Process for extracting catechuic polyphenols from cinquefoil; the extract obtained and its use
Inventor: NKILIZA JEAN
IPC: A61K8/368
Filed: 1997-04-09
Abstract: The invention concerns a process for extracting essentially oligomeric catechuic polyphenols from cinquefoil. The process involves the following steps: a) the whole plant, or a part of the plant, is treated with a polar organic solvent, either pure or mixed with water; b) the extract from step (a) is evaporated to dryness at a temperature of at most 60 degrees C; c) the residue from step (b) is dissolved in water and the resulting aqueous solution is subjected to extraction using a solvent which is immiscible in water and able to dissolve oligomeric catechuic polyphenols; d) the organic solution from step (c) is evaporated to dryness at a temperature of at most 60 degrees C. The invention also concerns the extract thus obtained and its use as a compound that acts against radicals and/or UV radiation.
Patent CA-2202459-A1 (CA)
Title: Heterocycles spiroalkylamines et spiroalcoxy substitues, leur procede de preparation et leur utilisation comme pesticides et fongicides
Inventor: BRAUN PETER
IPC: C07D239/34
Filed: 1995-10-05
Abstract: Des composés répondent à la formule (a), dans laquelle Het désigne 4-pyridyle ou 4-pyrimidinyle substitués; X désigne NH, O ou S(O)¿0-2?; E désigne une liaison ou alcandiyle; Y et Z désignent CH¿2?, O et/ou S(O)¿0-2?; W désigne (CH¿2?)¿0-4?; R?4¿ et R?5¿ désignent halogène, (halogénure d')alkyle, (halogénure d')alcoxy ou alkylthio; r et s = 0-2; U désigne une liaison, O, S(O)¿0-2? ou imino éventuellement substitué; et V désigne une liaison CO, SO¿2?, -CQ-T- ou -CT' = N-; ou U+V désignent ensemble une liaison double; et R?6¿ a la définition donnée dans la description. L'invention concerne également le procédé de préparation de ces composés et leur utilisation comme pesticides et fongicides.
Patent CA-2203926-A1 (CA)
Title: Liquid dispensing apparatus and methods
Inventor: IVRI YEHUDA
IPC: A61M15/00
Filed: 1996-08-22
Abstract: The invention provides method and apparatus for nebulizing liquids. A liquid supplier (24) delivers a predetermined unit volume of liquid to the rear surface (40). A vibrator vibrates the thin shell member (36) to eject liquid droplets from the front surface (38) of the thin shell member.
Patent CA-2205357-A1 (CA)
Title: Stain resistant composition containing sulphonated surfactant
Inventor: NGUYEN VAN GIAO
IPC: D06M13/262
Filed: 1995-11-17
Abstract: A direct application process by spray, pad, foam, flood or roller coating of a chemical composition of Novolak resin, polymethacrylic acid, sulphated or sulphonated surfactants and a fluorochemical to provide stain resistance/release to fibrous material, particularly nylon and wool carpets. The finish offers desirable oil, water and dry soil repellency and acid dye stain release without adverse effect on texture (handle) and pile opening. The invention relates to the use of diethanolamine lauryl sulfate as a foaming surfactant that also has stain release property against artificial coloring material commonly found in food and beverages.