Patent SG-11201901129X-A (SG)
Title: Compositions comprising nanosilica particles and their use in methods of activating t lymphocytes for therapy
Inventor: POWELL JONATHAN JOSEPH
IPC: A61P35/00
Filed: 2017-08-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI HIM 011101 0 0111010111110111101110111110 Hi lil Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/029247 Al 15 February 2018 (15.02.2018) W I P0 I P C T (51) International Patent Classification: A61K 33/00 (2006.01) A61P 35/00 (2006.01) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (21) International Application Number: PCT/EP2017/070183 Published: — with international search report (Art. 21(3)) (22) International Filing Date: — before the expiration of the time limit for amending the 09 August 2017 (09.08.2017) claims and to be republished in the event of receipt of (25) Filing Language: English amendments (Rule 48.2(h)) (26) Publication Language: English (30) Priority Data: 1613772.1 10 August 2016 (10.08.2016) GB 1701827.6 03 February 2017 (03.02.2017) GB (71) Applicant: MEDICAL RESEARCH COUNCIL [GB/GB]; Polaris House, North Star Avenue, Swindon Wiltshire SN2 1UH (GB). (72) Inventors: POWELL, Jonathan Joseph; 145 Histon Road, Cambridge Cambridgeshire CB4 3JD (GB). FARIA, Nuno, Jorge, Rodrigues; 3 Starey Close, Milton Ernest Bedfordshire MK44 1RX (GB). HEWITT, Rachel Elaine; 28 Magdalene Close, Longstanton, Cambridge, Cam- bridgeshire CB24 3EG (GB). VIS, Bradley Michael; 487 Arundel St., Thunder Bay, Ontario, P7A 1L8 (GB). BASTOS, Carlos; 50 Tiverton Way, Cambridge, Cam- bridgeshire CB1 3TU (GB). Agent: KIDDLE, Simon et al.; Mewburn Ellis LLP, City (74) Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (84) 1-1 .4 IN 71' el cT ei EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 0 —.... 00 1-1 (54) Title: COMPOSITIONS COMPRISING NANOSILICA PARTICLES AND THEIR USE IN METHODS OF ACTIVATING T 0 N LYMPHOCYTES FOR THERAPY C (57) : Compositions comprising silica particles having a mean size by standard particle sizing of between 0.5 nm and 20 nm are described for used in activating lymphocytes in culture or in whole blood.