baber/WOPTO huggingface dataset:
Patent CA-2397773-A1 (CA)
Title: Universal procedure for refolding recombinant proteins
Inventor: LIN XINLI
IPC: A61K39/00
Filed: 2000-12-28
Abstract: A universal folding method that has been demonstrated to be effective in refolding a variety of very different pro-teins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The method has two key steps to unfold and then refold the proteins expressed in the inclusion bodies. The first step is to raise the pH of the protein solution in the presence of denaturing agents to pH greater than 9, preferably 10. The protein solution may be maintained at the elevated pH for a period of up to about 24 hours, or the pH immediately decreased slowly, in increments of about 0.2 pH units/24 hours, until the solution reaches a pH of about 8.0, or both steps used. In the preferred embodiment, purified inclusion bodies are dissolved in 8 M urea, 0.1 M Tris, 1 mM  glycine, 1 mH EDTA, 10 mM beta-mercaptoethanol, 10 mM dithiothreitol (DTT), 1 mM redued glutathion (GSH), 0.1 mM oxidized glutathion (GSSG), pH 10. The absorbance at 280 nm (OD280) of the protein solution is 5Ø This solution is rapidly diluted into 20 volumes of 20 mM Tris base. The resulting solution is adjusted to pH 9.0 with 1 M HCl and is kept at 4 C for 24 hrs. The pH is adjusted to pH 8.8 and the solution is kept at 4 C for another 24 hrs. This process is repeated until the pH is adjusted to 8Ø After 24 hrs at pH8.0, the refolded proteins can be concentrated by ultrafiltration and applied to a gel filtration column for purification.
Patent CA-2402174-A1 (CA)
Inventor: TORISU KAZUHIKO
IPC: A61K31/4439
Filed: 2001-03-08
Abstract: L'invention se rapporte à des dérivés indole représentés par la formule générale (I) (dans laquelle chaque symbole est défini dans la description); à un procédé de préparation de ces dérivés et à des antagonistes du récepteur de DP contenant ces dérivés en tant que principe actif. Les composés de la formule générale (I) se lient au récepteur de DP pour exercer leur antagonisme, et ils s'avèrent par conséquent utiles pour prévenir et/ou traiter les allergies (du type rhinite allergique, conjonctivite allergique, dermite atopique, allergie alimentaire, mastocytose systémique, troubles liés à une activation systémique de mastocytes, choc anaphylactique, constriction de la trachée, urticaire et eczéma), les maladies associées à des démangeaisons (du type dermatite et urticaire), les troubles secondaires résultant du grattage, de la frappe ou d'autres comportements provoqués par les démangeaisons (du type cataracte, décollement de la rétine, inflammation, infection et trouble du sommeil), les inflammations, les syndromes pulmonaires obstructifs chroniques, les troubles de la reperfusion du myocarde ischémique après récupération de conditions ischémiques, les maladies cérébrovasculaires, les pleurésies compliquées par de la polyarthrite rhumatoïde, les recto-colites hémorragiques et autres maladies.
Patent CA-2402505-A1 (CA)
Title: Sealable and manipulable pre-filled disposable pipette
Inventor: XIA FRANK ZHISHI
IPC: A61J1/00
Filed: 2002-01-10
Abstract: An improved pr~-filled disposable pipette (10) consisting of a hollow tube (12) dimensioned to enclose a medicinal product and having attached a medication transfer tube (22) from where the pipette is filled and the medicinal product release d. The improvement consists in having a primary grasping tab (32) attached to an upper end (14) of the bulb (12); a secondary grasping tab (38) attached to each side of the  tube (22); and a support tab (52) also attached to each side of the tube (22) near the lowe r end (26) of the tube (22). The primary and secondary grasping tabs (32, 38) allow the pipette (10) to be conveniently and easily handled without having to grasp the sensitive bul b (12) or to directly grasp the tube (22). The support tab (52) functions to allow the pipette (10) to be placed on a conveyor rack apparatus (88) from where the pipette (10) can be automatically filled and sealed by a cap (72) or heat applied foil (82).</SD OAB>
Patent CA-2403902-A1 (CA)
Title: Malonamic acids and derivatives thereof as thyroid receptor ligands
Inventor: ASPNES GARY ERIK
IPC: A61P27/06
Filed: 2001-03-07
Abstract: The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula (I), which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression and osteoporosis. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.
Patent CA-2404631-A1 (CA)
Title: Apparatus and system for the production of plastic lenses
Inventor: BUAZZA OMAR M
IPC: B29C39/42
Filed: 2001-03-30
Abstract: A lens forming apparatus for preparing a plastic eyeglass lens includes a first lens curing unit (810), a second lens curing unit (820) and a conveyor system (850) for moving mold assemblies between the two units. The apparatus may also include an anneal unit (830) configured to apply heat to a substantially polymerized lens. The apparatus may be used to form an eyeglass lens from a lens forming composition that may include an aromatic containing polyether polyethylenic functional monomer, a photoinitiator, and a coinitiator. The lens forming composition may be cured by the application of activating light or activating light and heat.
Patent CA-2405282-A1 (CA)
Title: Micro-composite polymer/polymer materials with semicrystalline dispersed phase and preparation method
Inventor: CASSAGNAU PHILIPPE
IPC: B29C48/405
Filed: 2001-04-06
Abstract: The invention concerns a micro-composite polymer/polymer material comprising 25 to 35 wt. % of a semicrystalline polymer (I), forming a dispersed phase localised inside a thermoplastic or elastomeric polymer (II) forming a matrix, the temperature of crystallisation of the polymer forming a dispersed phase being higher by at least 20 ·C than the melting or softening point of polymer (II) forming the matrix, and the dispersed phase of said material having specifically a morphology such that it induces crosslinking of the continuous phase. The invention also concerns a method for obtaining said material comprising steps which consist in: extruding, at regulated temperature, said mixture of melted polymers, said regulation temperature being decreasing from the feeding zone (A) to the die zone (F) of said extruding machine (1) so that the temperature of the material in said die zone (F) is lower than the temperature of recrystallisation or solidification of polymer (I) and higher than the melting or softening point of polymer (II); and cooling at room temperature the resulting micro-composite material.
Patent CA-2405586-A1 (CA)
Inventor: SANTOY LUPE
IPC: A41D13/11
Filed: 2001-04-26
Abstract: An improved multi-layer face mask (10) has at least one adhesive strip appli ed between the inner face cover layer (36) and the intermediate filter layer (38). The adhesive strip (40) is defined so as to extend across the filter body and is bounded on each longitudinal side (42) by longitudinally extendi ng regions (54) that are free of adhesive. The adhesive strip (40) may be disposed along a pleat (24) formed in the face mask body. For example, the adhesive strip (40) may have a width so as to extend between parallel fold lines of a pleat (24).
Patent CA-2406088-A1 (CA)
Title: Novel phenyl-propargylether derivatives
Inventor: LAMBERTH CLEMENS
IPC: C07C323/62
Filed: 2001-05-15
Abstract: The invention relates to phenyl-propargylether derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5 R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio, optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl or optionally substituted alkynylsulfonyl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.
Patent CA-2406299-A1 (CA)
Title: Bearing assembly and method
Inventor: AUBER PHILIPPE
IPC: F16C17/03
Filed: 2002-10-02
Abstract: A bearing assembly and method in which a bearing cage is disposed around a rotating member and a housing is disposed around the cage. A first portion of the radial outer surface of the cage extends in a slightly spaced relation to the corresponding portion of the inner surface of the housing, and a second portion of the radial outer surface of the cage projects from the first portion in a radial direction and engages the corresponding portion of the inner surface of the housing.
Patent CA-2407567-A1 (CA)
Title: Procede permettant de fournir un service de communication vocale par paquets dans un reseau de communication sans fil et architecture de reseau correspondante
Inventor: PARK DO-JUN
IPC: H04W36/14
Filed: 2002-01-11
Abstract: L'invention a trait à un procédé permettant de fournir un service de communication vocale et un service supplémentaire à un terminal de réseau de circuits à l'aide d'un réseau par paquets, et à une architecture de réseau correspondante. Dans cette architecture de réseau, un message enregistré (RAN) fournit un service de communication au terminal de réseau de circuits, une passerelle intermédiaire permet que ce terminal de réseau de circuits soit identifié comme un terminal de réseau par paquets dans le réseau par paquets grâce à l'enregistrement IP du terminal de réseau de circuits. Une passerelle d'accès fournit un trafic prédéterminé qui sert d'interface lors d'une demande issue de la passerelle intermédiaire et transmet un trafic vocal depuis le terminal de réseau de circuits vers un terminal d'une partie appelée au moyen du réseau par paquets.
Patent CA-2408361-A1 (CA)
Title: Copper alloy comprising zinc, tin and iron for electrical connection and a process for preparing the alloy
Inventor: FINNEY M PARKER
IPC: H01R4/68
Filed: 2001-05-07
Abstract: Copper alloys for electrical applications, particularly in the computer industry, and a process for making the copper alloys. The copper alloys contain 13-15 % by weight of zinc, 0.7-0.9 % by weight of tin, and 0.7-0.9 %  by weight of iron, the balance being copper. The low tin and iron content an d high zinc content provide high tensile and yield strengths, a high conductivity, and a low cost for the copper alloys.
Patent CA-2408981-A1 (CA)
Inventor: MORIHIRO SHIGEVASU
IPC: C08F220/04
Filed: 2002-10-18
Abstract: It is an object of the present invention to provide an emulsion composition for vibration damping materials which is capable of giving water-based vibration damping materials exhibiting very satisfactory thermal drying characteristics and vibration damping properties through improved dispersibility and stability and an emulsion composition for chipping-resistant materials which is capable of giving water-based chipping-resistant materials exhibiting satisfactory thermal drying characteristics and chipping-resistant properties.        The present invention is directed to an emulsion composition for vibration damping materials which comprises an emulsion obtained by polymerizing a monomer composition containing an unsaturated carboxylic acid monomer as an essential component and a crosslinking agent.        The present invention is further directed to an emulsion composition for vibration damping materials or chipping-resistant materials which comprises an emulsion obtained by polymerizing a monomer composition containing an unsaturated monomer having two or more functional groups as an essential component.
Patent CA-2409423-A1 (CA)
Inventor: ATARASHI REI
IPC: H04L12/70
Filed: 2002-10-23
Abstract: The present invention enables control to be prioritized based on data content over a network such as the Internet. In the present invention, a data sending unit adds metadata relating to data content upon data, decides priority of resources based on metadata while referring to a metapolicy, generates a packet, and sets priority at a part of the header information of the packet. A data transmission unit then refers to a DSCP table and then transmits or discards the packet based on communication control based on priority set at the packet.
Patent CA-2411240-A1 (CA)
Title: Wound dressing
Inventor: VON DER WETH ANDREAS MATTHIAS
IPC: A61L15/28
Filed: 2001-05-31
Abstract: Wound dressings consisting of a self supporting cellulosic films having two substantially parallel and opposed surfaces made by a non-microbiological (preferably regenerative) method with a wet flatness less than about 35 seconds. Preferably average thicknesses are up to about 2 mm, and water permeabilities are at least about 100 g/m2.d. They preferably have a molecul ar weight cut off such that micro-organisms are substantially prevented from crossing them, (film-pore size preferably less than about 1 ~m), have haze values of at least about 10 %, and an average surface roughnesses of at leas t about 10 ml/min. The films can include particles in amounts of from about 0. 5 % to about 25 % of the total film weight, the particles preferably being substantially on or near at least one film surface. The mean dimension of th e particles along their longest axis is preferably from about 5 m~ to about 5 mm. The particles are preferably cellulose fibers from a wood source.</SDOAB >
Patent CA-2412028-A1 (CA)
Title: Sun tracking panel for a solar house and a solar house equipped with the sun tracking panel
Inventor: SZYMOCHA KAZIMIERZ
IPC: H02S40/44
Filed: 2002-11-18
Abstract: A sun tracking panel for a solar house includes a support structure having a horizontally oriented arcuate mounting face. Horizontal guide rails are attached to arcuate mounting face of the support structure. A solar panel support is mounted on the guide rails. A solar panel is supported by the solar panel support. A drive system is provided for moving the solar panel support along the guide rails, so that the solar panel tracks horizontal movement of the sun. It is preferred that the solar panel be mounted to the solar panel support for pivotal movement about a substantially horizontal pivot axis in order to better track the sun as its height changes in the sky during the year. It is also preferred that the support structure be incorporated into the solar house.
Patent CA-2412063-A1 (CA)
Title: Biomechanical heart valve prosthesis and method for making same
Inventor: GABBAY SHLOMO
IPC: A61F2/24
Filed: 2002-11-18
Abstract: A system and method are disclosed for covering a mechanical heart valve with biological tissue to provide a biomechanical heart valve prosthesis.     The prosthesis includes a mechanical heart valve having a moveable portion mounted within a generally annular support that permits substantially unidirectional flow of blood therethrough. One or more sheets of a biological tissue material are applied around the support heart valve to provide a sewing ring that includes the biological tissue material.
Patent CA-2412223-A1 (CA)
Title: Compositions and methods for the therapy and diagnosis of colon cancer
Inventor: JIANG YUQIU
IPC: C12N5/09
Filed: 2001-06-08
Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tum or proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used,  for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA  encoding such a protein, in a sample are also provided.
Patent CA-2412234-A1 (CA)
Inventor: WINTERHALTER PETER
IPC: F15B11/036
Filed: 2001-05-22
Abstract: The invention relates to a device for pneumatically operating a tool which c an be driven by means of pressure, such as especially, pneumatic pliers (1). Th e device has a cylinder (3) comprising one or more pneumatically operated, nonpositively fitted pistons (5) arranged in a row, for generating a translatory force. The respective piston rods (6) of the pistons (5) are sealed against the preceding piston (5, 34) and guided in cylinder covers (1 3) by means of a seal (24), such as a lip seal. Components such as a wedge pist on (34) are functionally connected to the pistons, said wedge piston being coupled to a cuneiform wedge (35), for transferring the translatory force an d for operating the tool. The pistons (5, 34) are supported by at least one piston guidance strip (23), in the direction against the inner wall of the cylinder.
Patent CA-2412642-A1 (CA)
Title: Container having collapsible liner
Inventor: SINS VERONIQUE
IPC: B65D3/04
Filed: 2002-11-25
Abstract: A composite container is provided for vacuum packaging of products is disclosed having a generally tubular body portion having opposite ends and an inner surface. A liner is attached to the body portion for receiving the products inside the liner and the body portion of the container. The liner has a memory and is able to move between a position adjacent the body portion to a position about the products placed therein when a vacuum is applied to the products. When the vacuum is removed from the products, the liner automatically returns from the position about the products to the position adjacent the body portion so that the products can be easily removed.
Patent CA-2412923-A1 (CA)
Inventor: COLYAR JAMES J
IPC: C10G47/26
Filed: 2000-06-19
Abstract: A process for catalytic multi-stage hydrogenation of heavy hydrocarbonaceous feedstocks using catalytic ebullated bed reactors, operated at generally the same reaction conditions. In the process, the feedstock is reacted with hydrogen in a first stage catalytic ebullated bed reactor at operating conditions of 700-850 ~F temperature, 800-3000 psi hydrogen partial pressure at the reactor outlet, 0.2-2.0 V,/hr/V, liquid hourly space velocity, catalyst space velocity of 0.03-0.33 bbl/day per pound of fresh catalyst and at reduced superficial gas velocity of 0.02-0.3 ft/sec in each reactor, so as to provide increased percentage liquid volume and reduced gas hold-up in each reactor.  The first stage reactor effluent liquid portion is fed into the second stage reactor. The second stage reactor effluent is phase separated and fractionated to produce lower boiling liquid products. A vacuum bottoms fraction normally boiling above about 650 ~F and preferably above 900 ~F is recycled back to the first stage reactor.
Patent CA-2413641-A1 (CA)
Inventor: WEIMER MICHAEL JAMES
IPC: F02C7/00
Filed: 2002-12-05
Abstract: A heat treatment process that will restore the mechanical properties of an aircraft engine article that includes a cast Inconel 718 portion welded to a wrought portion. The heat treatment process includes placing an article that includes the Inconel 718 cast portion into a heat treatment chamber, evacuating the chamber to a suitable atmosphere, heating the chamber in a manner that minimizes distortion of the cast portion to a temperature in the range of 1950°F to 2050°F, holding the temperature in that range for a period of time sufficient to solution all the delta phase precipitates, and then cooling the article to room temperature in a manner that minimizes distortion of the article. After solution heat treatment, the wrought portion of the engine part can be removed and replaced and the engine article can be reprocessed,
Patent CA-2414406-A1 (CA)
Title: Use of egf-r protein tyrosine kinase inhibitors for preventing photoaging in human skin
Inventor: VOORHEES JOHN J
IPC: A61K8/00
Filed: 2001-06-26
Abstract: Photoaging of human skin, such as evidenced by the increased presence of matrix metalloproteinases after exposure to UV radiation, is prevented by pre-treating the skin with an inhibitor of epideremal growth factor receptor (EGF-R) prior to exposure. Such inhibitors are preferably natural, an example of which is geniestein. Compositions used for such purposes preferably include an EGF-R inhibitor as well as another MMP inhibitor, such as a retinoid.
Patent CA-2416755-A1 (CA)
Inventor: HYMAN BRADLEY T
IPC: A61K38/55
Filed: 2000-08-15
Abstract: The present invention relates to methods of treating neurological disorders with agents that bind to low-density lipoprotein receptor-related protein (LRP) receptors. The present invention also relates to methods of modulating  calcium influx and inhibiting cell death in neuronal cells by treating the neuronal cells with agents that bind to LRP. The present invention also relates to methods of identifying agents that modulate calcium influx in neuronal cells by binding to low-density lipoprotein receptor-related protei n.
Patent CA-2419101-A1 (CA)
Title: Process for the preparation of urethane (meth) acrylates
Inventor: WEIHRAUCH THOMAS
IPC: C09D5/03
Filed: 2003-02-14
Abstract: The invention relates to a process for the solvent-free, continuous preparation of urethane (meth)acrylates in an extruder, intensive kneader, intensive mixer or static mixer. These urethane acrylates can be used for the preparation of radiation-curable transparent or pigmented coming compositions, in particular powder coating compositions.
Patent CA-2423210-A1 (CA)
Title: Matrice de commutateurs optiques et procede de fabrication d'une telle matrice
Inventor: MADKOUR KAREEM
IPC: G02B5/08
Filed: 2003-03-20
Abstract: Matrice de commutateurs optiques, réalisée à partir d'un substrat à base de matériau semi-conducteur ou diélectrique, comportant : - au moins un ensemble de fibres optiques d'entrée (12) et au moins un ensemble de fibres optiques de sortie (14) orientés sensiblement perpendiculairement l'un par rapport à l'autre, - un ensemble de miroirs mobiles (5,13) disposés aux intersections des directions définies par les différentes fibres optiques, chaque miroir (13) étant apte à se déplacer pour assurer la réflexion d'un faisceau issu d'une fibre optique d'entrée à destination d'une fibre optique de sortie, - un ensemble de canaux définis entre les miroirs, et à l'intérieur desquels se propagent les différents faisceaux avant et après avoir rencontré les miroirs, caractérisée en ce que : - l'ensemble de miroirs est réalisé sur une première galette de substrat (2), ladite première galette étant recouverte d'une seconde galette de substrat (20), - les différents canaux (38) sont formés entre des zones en excroissance (34) présentes sous la seconde galette de substrat, lesdites zones en excroissance comportant des logements (33) à l'intérieur desquels peuvent se déplacer les miroirs mobiles.
Patent CA-2424622-A1 (CA)
Title: Use of neuropeptide-y antagonists in treatment of alcoholism
Inventor: HODGE CLYDE W
IPC: A61K31/352
Filed: 2001-10-02
Abstract: The present invention provides a method of treating of alcoholism and alcoho l abuse in a mammal comprising administering a therapeutically effective amoun t of an NPY receptor antagonist. The present invention is also directed to pharmaceutical compositions containing the same.