baber/WOPTO huggingface dataset:
Patent ES-2564161-T3 (ES)
Title: Polipéptidos de anticuerpos artificiales
Inventor: KOIDE SHOHEI
IPC: C12N15/70
Filed: 2001-07-11
Granted: 2016-03-18
Abstract: Un monocuerpo polipeptídico de fibronectina de tipo III (Fn3) que comprende una pluralidad de secuencias del dominio de la hebra ß de Fn3 que están unidas a una pluralidad de secuencias de la región bucle, en el que una o más secuencias de la región bucle del monocuerpo varían mediante la deleción, la inserción o la sustitución de al menos dos aminoácidos procedentes de las secuencias correspondientes de la región bucle en Fn3 natural; en el que el monocuerpo polipeptídico Fn3 comprende una mutación estabilizante de al menos un resto de aminoácido en comparación con una molécula de Fn3 natural, en el que la mutación estabilizante es una sustitución de al menos un resto de aminoácido que está implicado en una interacción electrostática desfavorable, en el que la mutación estabilizante es una sustitución de al menos una Asp 7, Asp23 o Glu 9 por otro resto de aminoácido, en el que dicha mutación estabilizante aumenta el punto de fusión del monocuerpo polipeptídico Fn3 en más de 0,1 ºC en comparación con un monocuerpo polipeptídico Fn3 que es idéntico excepto por el cambio.
Patent ES-2241873-T3 (ES)
Inventor: VROLIJK ENNO J
IPC: F23N5/12
Filed: 2001-08-14
Granted: 2005-11-01
Abstract: The invention relates to a control method for gas burners for providing a gas-air mixture. According to the invention, the ionization signal is only used for setting the mixing ratio dependent on the gas quality when the burner flame completely sweeps over the sensor generating the ionization signal. Outside the above-mentioned range, i.e. when the burner flame does not completely sweep over the sensor generating the ionization signal, the gas-air mixture is controlled dependent on the previously determined mixing ratio.
Patent ES-2258104-T3 (ES)
Inventor: DAINESE LINO
IPC: A41D13/00
Filed: 2001-09-05
Granted: 2006-08-16
Abstract: The present invention concerns a multi parts garment having multiple means for the protection of motor bikers and/or of athletes practicing various sports against traumas from accidental falls and violent impacts; said garment has in cooperation a jacket having seam sections in preset tearing yarn, a gilet internally joined thereto and integrally associated to plural pockets in a fabric having a predetermined porosity and preset to be inflated by means of compressed gas bottles, which are advantageously overlapped, or adhering to a back protector protecting the spine and having a rigid polymeric structure, and an electronic unit, receiving pulses from acceleration sensors between the motor biker and the motor vehicle.
Patent ES-2272546-T3 (ES)
Inventor: GREY MATTHEW JAMES
IPC: B65D83/16
Filed: 2001-10-22
Granted: 2007-05-01
Abstract: Secure dispensing apparatus is described which is adapted to dispense e.g. a prescription drug from an axial compression dispensing device ( 1 ). This is located in a housing ( 10 ) including a dispensing aperture ( 16 ). The axial compression dispensing device ( 1 ) is located in a central chamber of axial length slightly longer than that of the axial compression dispensing device, and structures ( 30 ) are provided at one end of the chamber movable with respect thereto to compress the axial compression dispensing device to cause dispensing via the dispensing aperture ( 16 ). The structures ( 30 ) comprises a central breakable axial stem ( 33 ) attached to a pressure plate ( 34 ), the pressure plate having a surface configuration on its side facing away from the axial compression dispensing device providing a set of surfaces ( 35 ) not in a plane transverse to the axis of the breakable stem, and apertures ( 36 ) in the end of the outer housing aligned with the set of surfaces of the pressure plate and none of the apertures ( 36 ) being coaxial with the breakable stem ( 33 ). Structures such as a wall ( 15 ) are provided to limit the amount of movement of the pressure plate ( 34 ) away from the end ( 11 ) of the outer housing containing the set of apertures ( 36 ).
Patent ES-2332402-T3 (ES)
Inventor: LIU JUN
IPC: A61K38/00
Filed: 2001-10-04
Granted: 2010-02-04
Abstract: The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.
Patent ES-2282311-T3 (ES)
Inventor: GODEFROY ALBAN
IPC: H01R13/58
Filed: 2001-10-02
Granted: 2007-10-16
Abstract: The object of the invention is a device for maintaining crimping seating regions of a flexible circuit in an electrical connector comprising a body (12) provided on the one hand with housings (14) adapted to receive contacts (16) with pins (24,25) to be crimped seated, and on the other hand with a flap (28) that is moveable in rotation with respect to this body about an axis (30). The invention also covers the connector equipped with this device.
Patent ES-2290195-T3 (ES)
Inventor: KLINGEBERG MICHAEL
IPC: A61P31/04
Filed: 2001-12-17
Granted: 2008-02-16
Abstract: The use of carbohydrates (I) is claimed as active agents for treating intestinal infections in animals, where (I) is not degradable by enzymes in the digestive tract, is other than lactulose and is selected from oligosaccharides, oligosaccharide derivatives, hydrolyzates of polymeric carbohydrates and their mixtures. An independent claim is also included for animal feedstuffs (specifically dietetic feedstuffs) containing (I). ACTIVITY : Antibacterial; Virucide; Fungicide; Antiparasitic; Antiinflammatory; Antidiarrheic; Analgesic; Antiemetic; Antipyretic. MECHANISM OF ACTION : Improvement of condition of bacterial flora; Prevention of deposition and adhesion of pathogenic bacteria on the intestinal epithelium. Some (I) are fermented by the intestinal flora to give lower fatty acids (especially butyric acid), lactic acid and/or acetic acid, which reduce the pH in the large intestine, promote growth of non-pathogenic bacteria and inhibit growth of pathogenic bacteria. Some (I) inhibit deposition of pathogenic bacteria on the intestinal epithelium or block the fimbriae of pathogenic bacteria to inhibit adhesion to the intestinal epithelium.
Patent ES-2283463-T3 (ES)
Inventor: GEFTER MALCOLM L
IPC: A61K47/48
Filed: 2001-11-27
Granted: 2007-11-01
Abstract: The present invention provides therapeutic agents suitable for treating an amyloidogenic disorder, as well as pharmaceutical compositions comprising the therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an amyloidogenic disorder, e.g., Alzheimer's disease, in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
Patent ES-2241902-T3 (ES)
Inventor: SEEFELD MARK A
IPC: C07D471/04
Filed: 2001-12-07
Granted: 2005-11-01
Abstract: Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections: wherein: R<SUP>1 </SUP>is Ar or Het; R<SUP>2 </SUP>is C<SUB>1-6</SUB>alkyl, (R'')<SUB>2</SUB>N-(CH<SUB>2</SUB>)<SUB>m</SUB>- or Ar-C<SUB>0-6</SUB>alkyl; X is H, C<SUB>1-4</SUB>alkyl, OR', SR', C<SUB>1-4</SUB>alkylsulfonyl, C<SUB>1-4</SUB>alkylsulfoxyl, CN, N(R')<SUB>2</SUB>, CH<SUB>2</SUB>N(R')<SUB>2</SUB>, NO<SUB>2</SUB>, CF<SUB>3</SUB>, CO<SUB>2</SUB>R', CON(R')<SUB>2</SUB>, COR', NR'C(O)R', F, Cl, Br, I, or CF<SUB>3</SUB>S(O)<SUB>r</SUB>-; R' is H, C<SUB>1-6</SUB>alkyl or Ar-C<SUB>0-6</SUB>alkyl; each R'' independently is H, C<SUB>1-6</SUB>alkyl or Ar-C<SUB>0-6</SUB>alkyl; m is 1 or 2; n is 0, 1 or 2; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
Patent ES-2218481-T3 (ES)
Inventor: SCHLIMPER WERNER
IPC: E03C1/046
Filed: 2002-03-09
Granted: 2004-11-16
Abstract: A shower unit comprises a shower head (6) and a hose (8) which supplies it with water, and a pump (4). An additional agent is supplied to a nozzle located in the shower head, and an additional hose connects the pump to the nozzle. The pump has a dosing valve for at least the additional agent. The additional agent hose consists of polyvinyl chloride (PVC).
Patent ES-2278828-T3 (ES)
Inventor: STANIFORTH JOHN NICHOLAS
IPC: A61K9/72
Filed: 1996-01-31
Granted: 2007-08-16
Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler.The inclusion of additive material (4) in the powder has been found to give an increased respirable fraction of the active material.
Patent ES-2280464-T3 (ES)
Inventor: VILADOT PETIT JOSEP-LLUIS DR
IPC: A61Q19/00
Filed: 2002-09-10
Granted: 2007-09-16
Abstract: Polyamide microcapsules having an average diameter of 0.1-5 mm are prepared by mixing an aqueous phase, in which diamines and/or triamines, anionic surfactants, hetero polysaccharides or polymers and optionally additives are dissolved, with an oil phase in which dicarboxylic acid chlorides are dissolved, to form a water-in-oil emulsion such that a polycondensation reaction occurs at the interfacial boundaries to form polyamide microcapsules.  Polyamide microcapsules (I) having an average diameter of 0.1-5 mm are prepared by:  (a) preparing an aqueous phase in which diamines and/or triamines (A1), anionic surfactants (A2), hetero polysaccharides or polymers (A3) and optionally additives (A4) are dissolved;  (b) preparing an oil phase in which dicarboxylic acid chlorides (B1) are dissolved;  (c) mixing (A) and (B) to form a water-in-oil emulsion such that a polycondensation reaction occurs at the interfacial boundaries to form polyamide microcapsules (I) and optionally;  (d) filtering and washing the microcapsules (I);  (e) treating the purified microcapsules (I) with a calcium salt solution to harden them; and  (f) filtering, washing and drying the hardened polyamide microcapsules (I).
Patent ES-2269629-T3 (ES)
Title: Composicion tintorea que contiene p-aminofenol o p-fenilenmina sustituida con sililo.
Inventor: RICHARD HERVE
IPC: C07F7/08
Filed: 2002-08-30
Granted: 2007-04-01
Abstract: Composición tintórea que contiene como base de oxidación al menos un compuesto que responde a la fórmula (I) siguiente, así como las sales cosméticamente aceptables correspondientes: (Ver fórmula) donde: - A representa OH o NH2; - R1 y R2, idénticos o diferentes, representan hidrógeno, un radical alquilo C1-C8 lineal o ramificado, un radical hidroxialquilo C1-C6 o el radical -Y-B; R1 y R2 juntos forman con el átomo de nitrógeno al que están unidos un heterociclo de 4 a 7 eslabones eventualmente substituido por uno o varios radicales alquilo C1-C3, OH, NH2 o Z-B;con la condición de que, cuando A represente OH, entonces R1 y R2 representen hidrógeno; - R3 y R4, idénticos o diferentes, representan hidrógeno, un radical alquilo C1-C4, un radical alcoxi C1-C4, un halógeno o el radical -Z-B; - Y representa una cadena hidrocarbonada C1-C8 saturada o insaturada, lineal o ramificada, que puede estar interrumpida por un heteroátomo seleccionado entre O, S o NR, siendo R un átomo de hidrógeno o un radical alquilo C1-C4; - Z representa una cadena hidrocarbonada C1-C8 saturada o insaturada, lineal o ramificada, que puede estar interrumpida por un heteroátomo seleccionado entre O, S o NR¿, siendo R¿ un átomo de hidrógeno o un radical alquilo C1-C4; un radical O-Y o un radical NR¿-Y, donde R¿ representa un átomo de hidrógeno o un radical alquilo C1-C4; - B es el grupo Si-SiR5R6R7, donde R5, R6 y R7, idénticos o diferentes, representan un radical alquilo C1-C4 o un radical fenilo; con la condición de que al menos uno de los grupos R1, R2, R3 y R4 represente -Y-B o -Z-B.
Patent ES-2256467-T3 (ES)
Inventor: EDWARDS DAVID
IPC: A61M15/08
Filed: 2002-03-20
Granted: 2006-07-16
Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.
Patent ES-2264482-T3 (ES)
Title: Derivados de oxazol sustituidos por acido carboxilico para uso como activadores de ppar-alfa y gamma en el tratamiento de diabetes.
Inventor: BINGGELI ALFRED
IPC: C07D413/12
Filed: 2002-05-06
Granted: 2007-01-01
Abstract: Compuestos de fórmula (I) (Ver fórmula) en donde R 1 es arilo o heteroarilo; R 2 , R 3 , R 4 y R 6 independientemente el uno del otro son hidrógeno, hidroxilo, alquenilo C2 - 8, halógeno, alquilo C1 - 7 o alcoxilo C1 - 7, en donde al menos uno de R 2 , R 3 , R 4 y R 6 no es hidrógeno, o R 3 y R 4 están unidos el uno al otro para formar un anillo junto con los átomos de carbono a los que están unidos, y R 3 y R 4 juntos son -CH=CH-S-, -S-CH=CH-, -CH=CH-O-, -O-CH=CH-, -CH=CH-CH=CH-, -(CH2)3 - 5-, -O-(CH2)2 - 3- o -(CH2)2 - 3-O- y, en donde R 2 y R 6 son como se ha definido antes; R 5 es alcoxilo C1 - 7, alqueniloxilo C2 - 8, (Ver fórmula) R 7 es hidrógeno o alquilo C1 - 7; R 8 es hidrógeno o alquilo C1 - 7; R 9 es hidrógeno o alquilo C1 - 7; R 10 es arilo; n es 1, 2 o 3; en donde el enlace entre el átomo de carbono C a y el átomo de carbono C b es un enlace de átomos de carbono doble o sencillo.; y sales farmacéuticamente aceptables y ésteres de los mismos; en donde ¿arilo¿ es un grupo de fenilo o naftilo que puede estar opcionalmente mono- o multi-sustituido por halógeno, hidroxilo, CN, CF3, NO2, NH2, N(H, alquilo C1 - 7), N(alquilo C1 - 7)2, carboxilo, aminocarbonilo, alquilo C1 - 7, alcoxilo C1 - 7, fenilo y/o feniloxilo, ¿heteroarilo¿ es un anillo aromático de 5 o 6 miembros que puede comprender 1, 2, o 3 átomos elegido entre nitrógeno, oxígeno y/o azufre o un grupo aromático bicíclico que comprende dos anillos de 5 o 6 miembros, en donde uno o ambos anilos puede contener 1, 2 o 3 átomos elegidos entre nitrógeno, oxígeno o azufre, cuyo grupo heteroarilo puede estar opcionalmente mono- o multi-sustituido por halógeno, hidroxilo, CN, CF3, NO2, NH2, N(H, alquilo C1 - 7), N(alquilo C1 - 7)2, carboxilo, aminocarbonilo, alquilo C1 - 7, alcoxilo C1 - 7, fenilo y/o feniloxilo;
Patent ES-2327501-T3 (ES)
Inventor: SCHROEDER JOSEPH E
IPC: F22B1/18
Filed: 2002-12-04
Granted: 2009-10-30
Abstract: An evaporator in a steam generator extracts heat from high temperature gases to convert heated water into saturated steam. The evaporator includes two sections-a once-through section and a circulation section, both of which include tubes located in the flow of hot gases. Heated water flows through the tubes of the once-through section at a rate sufficient to maintain the interiors of its tube fully wetted while enabling steam to develop in that water, with the steam having a quality of at least 20%. The circulation section includes a drum that is connected to the tubes of that section such that water from the drum circulates through the tubes and then back to the drum, with the circulation being such that the water in the tubes of the circulation section keeps the tubes fully wetted while steam develops in that water. The water from the tubes of the once-through section discharges into the drum as does the water circulating back from the tubes of the circulation section. Within the drum, the steam formerly entrained in the water escapes. Since the tubes of both sections remain fully wetted the heat transfer occurs most efficiently. The presence of the once-through section enables the circulation section to be reduced in size and this shortens start up. The drum confines most impurities to the liquid water that is circulated in the circulation section, and these impurities may be removed through a blowdown.
Patent ES-2286339-T3 (ES)
Inventor: JAUSSAN VERONIQUE
IPC: A23L1/09
Filed: 1998-03-31
Granted: 2007-12-01
Abstract: A nutritional composition for diabetics. The composition contains a protein source, a lipid source, and a carbohydrate source. The composition includes a fibre mixture containing a viscous soluble fibre and inulin, a hydrolysate of inulin, or both. The fibre mixture may also contain insoluble fibre. When in liquid form, the nutritional composition has a low viscosity and excellent tube flow rates.
Patent ES-2340919-T3 (ES)
Inventor: KRIEGER THOMAS
IPC: A47F3/04
Filed: 2003-04-01
Granted: 2010-06-11
Abstract: The evaporator system has at least two evaporators (V,V') with multiple injection, each with at least four coolant pipes (1-4,6), and one or more coolant exchange lines (5,5') between the evaporators arranged so that a highly uniform thermal loading on the coolant pipes is achieved.
Patent ES-2282588-T3 (ES)
Inventor: PETZL PAUL
IPC: A62B35/04
Filed: 2003-02-11
Granted: 2007-10-16
Abstract: An auxiliary lanyard (20), attached to main lanyards (12,14), is coupled to an energy absorber (16) and is shorter than the main lanyards to function as an additional attachment unit placed after the energy absorber.
Patent ES-2505250-T3 (ES)
Title: Convertidor de rollo de papel cortado por penetración
Inventor: WALLACE MARCUS T
IPC: B26D3/16
Filed: 2003-02-04
Granted: 2014-10-09
Abstract: Un aparato de corte de un rollo de material 12 en hoja, que comprende: una cuchilla 14 alargada que presenta un extremo 16 distal; una guía 18 de corte fijada a la cuchilla alargada en un extremo proximal y situada para dirigir el extremo 16 distal de la cuchilla alargada en dirección al rollo de material 12 en hoja; y un soporte 20 situado para mantener el rollo de material 12 en hoja próximo a la cuchilla 14 alargada; caracterizado porque la cuchilla alargada incluye una cadena y un conjunto de dientes de corte dispuestos sobre la cadena y en el que la guía de corte está dispuesta para dirigir la cuchilla para cortar por penetración el rollo de material en hoja mediante el corte del rollo de material en hoja con la porción de la cadena que cruza el extremo distal de la cuchilla alargada.
Patent ES-2305456-T3 (ES)
Inventor: FANTON XAVIER
IPC: G02F1/1524
Filed: 2003-02-04
Granted: 2008-11-01
Abstract: The subject of the invention is an essentially ceramic target for a sputtering device, especially for magnetically enhanced sputtering, said target comprising predominantly nickel oxide, the nickel oxide NiOx being oxygen-deficient with respect to the stoichiometric composition.
Patent ES-2315491-T3 (ES)
Title: Metodo para controlar una maquina lavadora accionada por motor y sistema de control para el mismo.
Inventor: KOO BON KWON
IPC: D06F33/02
Filed: 2003-05-15
Granted: 2009-04-01
Abstract: Un método para controlar una máquina lavadora accionada por motor, de tal modo que el método comprende las etapas de: (S1) generar una orden de interrupción para frenar un motor (51) en movimiento durante un ciclo de lavado; y está caracterizado por: (S2) aplicar un primer voltaje o tensión de fase invertida a un terminal de entrada de tensión del motor (51) en movimiento, de tal modo que la primera tensión de fase invertida se corresponde con una primera velocidad en curso en ese momento del motor (51); y (S4) cortocircuitar eléctricamente el terminal de entrada de tensión del motor (51) durante un periodo de tiempo predeterminado (Tpredeterminado) si una segunda tensión de fase invertida es mayor o igual que un nivel o valor de tensión crítico (Vc) (S3), de tal modo que la segunda tensión de fase invertida se corresponde con una segunda velocidad en curso del motor (51).
Patent ES-2383889-T3 (ES)
Title: Uso de inhibidores de vasopeptidasa en el tratamiento de nefropatía
Inventor: SCHAEFER STEFAN
IPC: A61K38/00
Filed: 2003-06-13
Granted: 2012-06-27
Abstract: Uso de un compuesto de fórmula (II) en donde R1 es hidrógeno, -CH2OC (O) C (CH3) 3, o un grupo acilo; R2 es hidrógeno, -CH2O-C (O) C (CH3) 3; un alquilo C1-C4; arilo, - (alquil C1-C4) -arilo; o difenilmetilo; X es - (CH2) n, en donde n es un número entero 0 ó 1, -S-, -O-, en donde R3 es hidrógeno, un alquilo C1-C4, arilo o aril- (alquilo C1-C4), y R4 es -CF3, alquilo C1-C10, arilo o aril- (alquilo C1-C4); B1 y B2, cada uno independientemente, son hidrógeno, hidroxi, -OR5, en donde R5 es alquilo C1-C4, arilo o - (alquil C1-C4) arilo, o en los casos en que B1 y B2 estén unidos a átomos de carbono adyacentes, B1 y B2 pueden ser tomados juntos con dichos átomos de carbono adyacentes para formar un anillo de benceno o metilendioxi, para la fabricación de un medicamento el tratamiento y/o la profilaxis de nefropatía en pacientes diabéticos.
Patent ES-2295628-T3 (ES)
Title: Pastas de pigmento acuosas que contienen pigmentos de mica y su utilizacion para la produccion de revestimientos acuosos de efecto decorativo.
Inventor: SAPPER GOTZ-EKKEHARD
IPC: C09D17/00
Filed: 2003-05-12
Granted: 2008-04-16
Abstract: Pasta acuosa de pigmentos libre de ligantes y de resinas de molienda que contiene, con respecto a su cantidad total, (A) del 15 al 25% en peso de como mínimo un pigmento de mica; (B) del 0, 45 al 0, 75% en peso de como mínimo un espesante de efecto no asociativo de al menos un producto de copolimerización de metacrilato basado en (met)acrilato de alquilo(C1-C6) y ácido (met)acrílico; (C) del 0, 1 al 0, 4% en peso de como mínimo una amina orgánica; (D) del 0, 1 al 12% en peso de como mínimo un agente tensioactivo no iónico y (E) como mínimo un 50% en peso de agua
Patent ES-2290530-T3 (ES)
Inventor: ASTELY DAVID
IPC: H04J99/00
Filed: 2003-12-22
Granted: 2008-02-16
Abstract: The present invention relates to methods in a communication system providing the steps of determining a set of spatial transport formats, and signalling a selected active set of transport formats to one or several mobile terminals. The transport formats are adjustable by means of adapting the parameters of their complex transmission weights and/or their transmission power by evaluating collected channel management information, e.g. feedback information received from the mobile terminals, in order to optimise the aggregate data throughput subject to quality and fairness requirements. Further the present invention allows to evaluate a plurality of feedback information received from the various mobile terminals, determining applicable data rates for each of the data streams associated to the transport formats, determining from said evaluation a scheduling scheme for scheduling data streams to said mobile terminals, and assigning applicable data rates to each of said scheduled data streams.
Patent ES-2282734-T3 (ES)
Inventor: BERNARD SAMUEL
IPC: H04L12/56
Filed: 2003-12-12
Granted: 2007-10-16
Abstract: The process involves establishing a session on a voice channel and a data channel. An active channel associated with recording of a context of a non-active channel in a digital data base of complementary equipment is alternatively selected among the voice channel and the data channel. The same session remains active during the selection of the channels.  An Independent claim is also included for a system of implementing a process for exchanging digital data between a mobile telephone and complementary equipment.