Patent SG-11201901661W-A (SG)
Title: Method of treating cancer by antisense oligonucleotides targeting prdm15
Inventor: GUCCIONE ERNESTO
IPC: G01N33/68
Filed: 2017-09-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/044239 Al 08 March 2018 (08.03.2018) WI P0 I P C T (51) International Patent Classification: A61K 31/7088 (2006.01) C12Q 1/68 (2006.01) Declarations under Rule 4.17: C12N 15/113 (2010.01) G01N 33/68 (2006.01) — of inventorship (Rule 4.17(iv)) A61P 35/00 (2006.01) Published: (21) International Application Number: — with international search report (Art. 21(3)) PCT/SG2017/050436 (22) International Filing Date: 04 September 2017 (04.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201607303Y 01 September 2016 (01.09.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis, Singapore 138632 (SG). (72) Inventors: GUCCIONE, Ernesto; c/o Agency for Science, Technology and Research, 1, Connexis, Fusionop- olis Way, #20-10, Singapore 138632 (SG). WEE, Keng — Boon, Dave; c/o Agency for Science, Technology and Re- search, 1, Connexis, Fusionopolis Way, #20-10, Singapore = - = 138632 (SG). Agent: AMICA LAW LLC; 30 Raffles Place, #14-01, (74) = Chevron House, Singapore 048622 (SG). = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, _ = SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every = (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = — 1-1 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 0\ M ei iv si. (54) Title: METHOD OF TREATING CANCER BY ANTISENSE OLIGONUCLEOTIDES TARGETING PRDM15 ---- (57) : The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in GC the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 C::::) mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic N strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample. C