baber/WOPTO huggingface dataset:
Patent CR-20150391-A (CR)
Title: Derivados 2-((4-amino-3-(3-fluoro-5-hidroxifenilo)-1h-pirazolo[3,4-d]pirimidin-1-il)metilo)-3-(2-(trifluoro-metilo)bencilo)quinazolin-4(3h)-ona y su uso como inhibidores de quinasa-3 fosfoinositida
Inventor: BROECKX RUDY LAURENT MARIA
IPC: A61P31/12
Filed: 2015-07-27
Abstract: La presente invención se refiere, inter alia, a un compuesto de la fórmula (I), y a composiciones que comprenden el compuesto, y al uso de los compuestos y composiciones de los compuestos en el tratamiento, por ejemplo, en el tratamiento de enfermedades inflamatorias, en particular, enfermedades inflamatorias respiratorias. La invención además se extiende a métodos de elaboración de dichos compuestos.
Patent CR-20190476-A (CR)
Title: Novel insect inhibitory proteins
Inventor: CHAY CATHERINE A
IPC: A01N63/50
Filed: 2018-04-03
Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins are also provided.
Patent CR-20200413-A (CR)
Title: Oxadiazole transient receptor potential channel inhibitors
Inventor: LÉPISSIER LUCE
IPC: C07D487/04
Filed: 2019-03-18
Abstract: <p>The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1?, R4? and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.</p>
Patent EC-SP034561-A (EC)
Title: Derivados puente de piperazina
Inventor: BLUMBERG LAURA COOK
IPC: A61P25/00
Filed: 2003-04-16
Abstract: La presente invención se refiere e un compuesto de formula (gráfico) o una sal farmacéuticamente aceptable éste en el que a, c, d, k, l, m, W, X, Y, Z, R1y R4 son como se han definido y que es útil para tratar la inflamación y otras dolencias inmunes.
Patent EC-SP045467-A (EC)
Title: Nuevos anticuerpos dirigidos contra factores tisulares como anticoagulantes
IPC: C12P21/08
Filed: 2004-11-30
Abstract: Nuevos anticuerpos que se unen con mayor afinidad al complejo del factor VIIa/factor tisular (FVIIa/TF) que al factor tisular (TF) solamente, no compiten por la unión a TF con FVII y FX e inhiben la activación de FX. Los anticuerpos se unen en el sitio de la lesión y previenen el inicio de trombosis. Los anticuerpos se pueden usar para el tratamiento de diversas afecciones trombóticas incluyendo, a modo de ejemplo, trombosis de venas profundas, coagulación intravascular diseminada y síndrome coronario agudo.
Patent EC-SP088110-A (EC)
Title: Compuestos de n-tio-antranilamida y su uso como pesticidas
Inventor: COTTER HENRY VAN TUYL
IPC: C07D401/04
Filed: 2008-01-16
Abstract: Compuestos de N-tio-antranilamida de la fórmula (I) en donde A es un grupo seleccionado de A1 y A2 en donde las variables y los índices son como se definen por la descripción, procesos para preparar los compuestos I, composiciones pesticidas que comprenden los compuestos I, uso de los compuestos I para el control de insectos, ácaros o nematodos, y métodos para tratar, controlar, prevenir o proteger a los animales contra una infestación o infección de parásitos con el uso de compuestos de la fórmula I.
Patent EC-SP099378-A (EC)
Title: Compuestos y composiciones como inhibidores de la proteina quinasa
Inventor: BREITENSTEIN WERNER
IPC: A61K31/506
Filed: 2009-06-02
Abstract: La invención proporciona una clase novedosa de compuestos, composiciones farmacéuticas que comprenden dichos compuestos y métodos de uso de los mismos para tratar o prevenir enfermedades o desórdenes asociados con la actividad anormal o desregularizada de la quinasa, particularmente enfermedades o desórdenes que involucran la activación anormal de c-kit, PDGFR? y PDGFR?.
Patent EC-SP951550-A (EC)
Title: Sistema de construccion modular clasificado a prueba de incendios
Inventor: DE ZEN VITTORIO
IPC: E04G11/06
Filed: 1995-10-12
Abstract: Piezas estructurales huecas de material termoplástico extruido, con corte transversal rectilíneo, que encajan en piezas de acoplamiento correspondientes, para el uso en la construcción de edificios modulares, caracterizados por el hecho de que dichas piezas han sido extruidas de un material de C.D.P. que contiene un agente retardador de humo y las superficies expuestas al medio ambiente de las mismas están cubiertas con un revestimiento. Preferiblemente la pieza tiene la forma de una pieza estructural hueca extruida de material termoplástico, con corte transversal rectilíneo, formada para encajar en una pieza de acoplamiento, para el uso en la construcción de edificios modulares, caracterizada por el hecho de que dicha pieza se extruye simultáneamente con un sustrato de C.D.P. que contiene una cantidad de entre 10% y 35% por peso del sustrato de un agente reforzador y controlador de expansión y una cantidad de aproximadamente 5% a 35% por peso del sustrato de un agente retardadorde humo, donde el total de ambos agentes es inferior a aproximadamente 45% por peso del sustrato, y un revestimiento que recubre las superficies de dicha pieza que quedan expuestas cuando dicha pieza está encajada en la pieza correspondiente en un edificio, y dicho sustrato es considerablemente más grueso que dicho revestimiento, el que forma una barrera protectora que aisla dicho agente retardador de humo del medio ambiente exterior de dicha pieza cuando la misma se halla incorporada en un edificio
Patent FR-1562886-A (FR)
IPC: A01D34/76
Filed: 1967-12-22
Granted: 1969-04-11
Abstract: 1,249,638. Rotary mowing machine. KUHN FRERES & CIE. 19 Nov., 1968 [22 Dec., 1967], No. 54861/68. Heading A1F. A rotary mowing machine includes bridge pieces 26 interconnecting the lower ends of bearing blocks generally indicated at 117a, 117b the bearing blocks supporting an inner race 16 of pinions 14 which drive the cutter blades 8 and being fastened by studs 19 to the upper section 2 of a two-section casing. In an alternative form (Fig. 6, not shown), a bridge piece 28 interconnects all the bearing blocks. To avoid jamming of the gear teeth, an assymetrical arrangement of the gears 13 and 14 is provided.
Patent GB-1051036-A (GB)
IPC: B23H3/00
Abstract: 1,051,036. Electrolytic machining. GARRETT CORPORATION. May 9, 1963 [May 11, 1962], No.18466/63. Heading C7B. Electrolytic machining apparatus includes an electrode assembly comprising an electrode of which a section is mounted for progressive movement with respect to and into a cut it forms in a workpiece on the application of a voltage between electrode and workpiece and the passage of electrolyte between them, the leading face of the electrode corresponding to the area and shape of the desired cut, and a solid insulating barrier lying immediately behind the said section of the electrode to prevent or limit side wall erosion of the cut. The cathode tool electrode is secured to a power driven holder insulated from the apparatus bed from which the workpiece connected as anode is also insulated and  electrolyte is fed through the electrode assembly to the work gap, the escaping electrolyte being collected and led to a reservoir from which it is pumped back through a filter to the electrode assembly. The electrolyte may either be fed through the tool or passed to the work gap along one side of the tool and removed from the other. The working portion of the electrode may comprise a disc-like member secured to the main body of the electrode by conducting bolts passing through an insulating member which also lines the electrolyte feed passage in the electrode body. An arrangement is described for cutting turbine wheel blades comprising an insulating housing 84 engaging the turbine wheel surface within which is movable a cathode tool and through which electrolyte is fed to one side of the tool working surface 80 and which escapes through a vent 87 in the housing. Several such electrode assemblies may be uniformly spaced around the turbine wheel circumference. In a modification Fig. 12 (not shown) the electrode tool is hollow and communicates with the electrolyte feed, electrolyte escaping along the sides of the cut and an insulating housing is not required. Typically the work gap is 1 to 2 mils. and the electrolyte is forced through it at a pressure of 200 to 250 p. s. i. In a modification of the electromachining process, the operative portion of the tool electrode is not provided with a solid insulating barrier behind it but electrolyte is forced through the work gap at such a pressure that it flows away along the walls of the cut leaving an air "wall" behind the electrode e.g. as in Fig. 16 where electrolyte is supplied to a tubular electrode 105 having a longitudinal slot 106 and supported between spaced yokes between which the work passes as cutting proceeds.
Patent GB-1053968-A (GB)
IPC: B62D/
Abstract: 1,053,968. Wheeled vehicle bogies. PNUEWAYS DEVELOPMENT CO. (PRIVATE) Ltd- May 21, 1964 [June 6, 1963; May 5, 1964], No 21089/64. Headings B7H and B7L. A mechanical reciprocal coupling arrangement of wheel vehicle bogies 1, 2 for roads or rail tracks, each having one or more pairs of wheels, and being pivotally mounted by means of turntables 3, 4 to each of a train of vehicle chassis or bodies 5, comprises two horizontal diagonally crossed links 6, 7 connected by ball- and-socket joints 6a, 6b, 7a, 7b to the bogies 1, 2, wherein the straight line through the joints 6a, 6b or 7a, 7b is tangential to the two imaginary circles y, y drawn through the joints 6a, 7a and 6b, 7b and centred on the vertical pivot axis of each bogie, when the transverse axes x-x of the bogies are parallel. The leading bogie or vehicle is steered by internal mechanism in the case of road vehicles, or by coaction of guide wheels associated with bogie or vehicle loadcarrying wheels, with side surfaces of track rails.
Patent GB-1054581-A (GB)
IPC: G05B19/418
Abstract: 1,054,581. Automatic control of position. GENERAL ELECTRIC CO. Feb. 21, 1964 [March 1, 1963], No.7439/64. Heading G3R. In an automatic system for positioning the rollers of a plurality of pairs of rollers between which material passes in a strip mill, data concerning each pair of rollers is digitally stored and a device sequentially selects the storage devices for a computer which processes the data to compute for each pair of rollers the zero correction factor, defined as the difference between the actual roller separating distance and the indicated roller separating distance, to allow for roller wear and thermal distortion whereby the position error, defined as the difference between the desired and corrected indicated roller separating distances, is subsequently sequentially determined for each pair of rollers and used to control a retroactive positioning device for each of rollers for reducing the position error.
Patent GB-1054856-A (GB)
IPC: A63B35/12
Abstract: 1,054,856. Swimming appliances. R. A. HARVEY. April 28, 1965 [May 1, 1964], No. 18261/64. Heading A6D. A power-driven swimming aid comprises a motor 1 which is either housed in a waterproof casing or is immune to immersion in water, the motor being fitted with a harness for attachment to the swimmer, and driving either a propellor 31 or a water jet propulsion system. The controls of the motor are mounted on a plate 44 strapped to the swimmer's hand, and floats 24 are preferably provided, mounted in the motor casing. Direction controls 35, 36 may also be provided.
Patent GB-1226389-A (GB)
IPC: D06F15/02
Filed: 1968-06-18
Abstract: 1,226,389. Washing machines. R. GROEBLI. 18 June, 1968 [30 June, 1967], No. 28942/68. Heading D1A. A washing machine comprises a rigid vat 2 with a medial part of reduced area and containing a rubber or like bag 3 secured at its upper end to vat 2 which has a perforated cover 5 and is carried in the bottom of a second vat 4, the bag 3 being lifted by water admitted to vat 2 or by means actuated by water pressure within vat 2 to agitate the clothes being washed. As shown, the bag 3 is secured beneath a rubber ring 15 or an integral metal part which reduces the crosssection. Vats 2 and 4 are enclosed in casing 1 with a hinged cover 6. Vat 2 has a raised bottom 2a on which bag 3 can rest and water is supplied thereto and exhausted therefrom through an electrically controlled three-way cock 8 connected also to a three-way cock 9 connected to vat 4. Electric or gas heating means are provided beneath vat 4. In another arrangement Fig. 2 (not shown) liquid is supplied to bellows (17) to lift bag 3 for washing and water is only supplied to the whole space beneath the bag for wringing.
Patent GB-1226395-A (GB)
IPC: G09G1/00
Filed: 1968-07-18
Abstract: 1,226,395. Cathode-ray tube displays. TELEFUNKEN PATENTVERWERTUNGS G.m.b.H. 18 July, 1968 [18 July, 1967], No. 34180/68. Heading H4T. Linear traces drawn on the screen of a cathode-ray display tube by deflection of the beam are broken up into segments having a desired pattern (e.g. to produce dot-dash, chain-dotted lines &c.) by controlling the intensity of the beam in accordance with such pattern. The latter is determined by the markspace ratio of a pulse pattern generator, e.g. a multivibrator, the output of which, as shown, is fed to one input of an AND gate U which is opened by the output of a timing circuit for the duration of each trace which is produced by connecting the vector generator to the tube deflection means (not shown). The output of gate U then opens and closes a switch S in accordance with the mark-space ratio of the pulses and correspondingly interrupts the supply of beam intensity control information which is fed via the switch and an amplifier to the brightness control electrode of the tube. When the vector generator is of the kind that causes all lines to be drawn in a constant time interval irrespective of their lengths the brightness information is suitably modulated so that all lines are of uniform brightness. The pulse pattern generator is arranged to be started in the same phase position by the start signal which is repetitive at the display repetition frequency. Alternatively, the generator may generate the pattern constantly and the start of the vector drawing arranged to occur at a particular phase position or the constantly operating generator may be brought into a desired phase position by a trigger pulse. Different pulse generators may be provided for the different patterns required or a single-pulse generator having a switchable pattern may be employed.
Patent GB-1227036-A (GB)
IPC: C25D7/00
Filed: 1969-02-26
Abstract: 1,227,036. Electro-plating elongated members. STANDARD TELEPHONES & CABLES Ltd. Feb.26, 1969, No.10259/69. Heading C7B. In a method of electro-plating a batch of elongated members each over a region adjacent one end while they are immersed in the electrolyte, e.g. of plating the ends of magnetic reed contact blades with gold, the elongated members are positioned in a container having insulating walls and an opening through which the ends to be plated project, the remaining parts thereof being screened by the insulating walls of the container. In the form shown six cylindrical containers 6 are supported by frame 5 about a tubular member 11. Each container 6 is provided with a disc-shaped cathode 8 in the base thereof and a loop-shaped cathode 10 about the neck of the container, all being connected via leads 12 to the cathode terminal 13. The cathodes may be of copper and the disc-shaped cathodes may be gold plated. An annular anode 16 is positioned about the group of containers. Agitation may be provided by orbital rotation of the structure comprising the containers 6 and support member 11.
Patent GB-1227691-A (GB)
IPC: C07H19/12
Filed: 1969-04-24
Abstract: 1,227,691. 1 - Glycosyl - 5 - azacytosines. CESKOSLOVENSKA AKADEMIE VED. 24 April, 1969 [8 May, 1968], No. 21132/69. Heading C2C. 1-Glycosyl-5-azacytosines of the general formula wherein R1 is a glycosyl residue, R<SP>2</SP> is a hydrogen atom or a C 1-4  alkyl group and R<SP>3</SP> and R<SP>4</SP>, which are the same or different, are each a hydrogen atom, a C 1-4  alkyl group or a C 7-10  aralkyl group, are prepared by reaction of a 1- peracylglycosyl - 1,2 - dihydro - 1,3,5 - triazin- 2-one of the general formula wherein R<SP>5</SP> is a peracylglycosyl residue, the acyl group containing from 2 to 10 carbon atoms, and X is a C 1-4  alkoxy or alkylthio group, with an alkali metal C 1-6  alkoxide and treatment of the resulting 1 -glycosyl- 1 ,2-dihydro - 4 - alkoxy - 1,3,5 - triazin - 2 - one of the general formula wherein R<SP>6</SP> is a C 1-6  alkyl group, with ammonia or an amine of the general formula R<SP>3</SP>R<SP>4</SP>NH. The two steps may be carried out simultaneously using the ammonia or amine in the form of an alkanol solution thereof, or the first step may be omitted.
Patent GB-1227977-A (GB)
IPC: B01J31/08
Filed: 1968-08-26
Abstract: 1,227,977. Noble metal catalysts. SCHOLVEN-CHEMIE A.G. 26 Aug., 1968 [8 Sept., 1967], No. 40751/68. Heading B1E. [Also in Division C2] A catalyst for the reaction of acetone with hydrogen to produce methyl isobutyl ketone is prepared by a partial ion exchange reaction in aqueous solution of the H ions of a strongly acid ion exchanger for the metal cations of a salt of a noble metal of Group VIII of the Periodic Table, with subsequent washing and reduction with hydrogen to convert the metal cations into metallic atoms. The metal is preferably palladium and the ion exchanger may be a macroporous sulphonated polystyron/divinylbenzol resin. The catalyst is prepared by treating an aqueous solution of the metal salt (e.g. palladium nitrate) with the acidic ion exchanger when the metal ions are quantitatively taken up. The resin is then washed with water and treated with hydrogen to restore the resin to the H+ form having the metal distributed largely in monomolecular form throughout its structure. The final catalyst preferably contains 0.001-0.5% by weight of palladium.
Patent GB-1228935-A (GB)
IPC: F16B37/12
Filed: 1968-07-08
Abstract: 1,228,935. Fixing devices. BOFORS-TIDAHOLMSVERKEN A.B. 8 July, 1968 [7 July, 1967], No. 32559/68. Heading F2H. A device for use in connecting a screwthreaded element 11 to a wall of sandwich construction comprises an internally-threaded member 5 of plastics material and arranged to engage with an externally-threaded member 4 having a threaded bore in which the screwthreaded element 11 can be engaged. The member 4 is provided with a rivet portion 8 in a thin-walled portion 7 of the shank of the member 4. The element 11 may be provided with a hook 15 for supporting a load from the wall which may comprise two glass fibre reinforced polyester sheets 1, 2 separated by a layer 3 of polyurethane foam.
Patent GB-1230211-A (GB)
IPC: C08J3/22
Filed: 1968-08-09
Abstract: 1,230,211. Polymer pigment compositions. VYSKUMNY USTAV CHEMICKYCH VLAKEN. 9 Aug., 1968 [20 Dec., 1967 (2)], No. 38171/68. Headings C3P and C3R. Linear synthetic polymers are pigmented by continuously injecting into a stream of the molten polymer a dispersion consisting of (I) 5- 60% of a pigment and (II) 80-95% of a polyglycol or a mixture of a polyglycol with up to 20% of an organic phosphite. The linear synthetic polymer may be a polyamide, a polyester, polyethylene or polypropylene. The pigment may be Chromophthal red, Chromophthal yellow, Chromophthal green, Chromophthal blue or Graphthol blue. The polyglycol may be polyethylene glycol, polypropylene glycol or a methyl or ethyl ether thereof. The phosphite may be of formula (RO) 3 P where R is alkyl or of formula (RC 6 H 4 O) 3 P, where R is alkyl or styrenyl, e.g. tricetyl phosphite, tri- (styrylphenyl) phosphite or tri-(nonylphenyl)- phosphite. A suitable apparatus is shown in the drawing in which 6 represents the polymer flow pipe which has a heating jacket 8 and dosing pump 7. The pigment dispersion is stored in tank 1 from which it may be expelled by gas pressure applied at 3 or by a screw conveyer to dosing pump 2. It is then heated at 4 and injected by dosing pump 5. The 3 dosing pumps are driven by electric motor 9 through gear-box 10.
Patent GB-1230457-A (GB)
IPC: F16K15/12
Filed: 1968-05-23
Abstract: 1,230,457. Valves. HOERBIGER VENTILWERKE A.G. 23 May, 1968 [30 May, 1967], No. 24653/68. Heading F2V. A spring plate for a multi-ring check valve comprises rings 2 adjacent ones of which are joined by two or, as shown, one web 3, all the webs lying along a common diameter. The plate is cylindrically dished about an axis parallel to the said common diameter, although the portions of the webs adjacent the sides of radial slot 4 are straight or at least of greater radius of curvature. The slot is enlarged at 5 to receive a guide-pin. In Fig. 3 (not shown), the webs are provided alternatingly on opposite sides of the plate centre. In Fig. 4 (not shown), a central clamping hub is provided as opposed to the sliding guidance offered by the inner rings of Figs. 1 and 3.
Patent GB-1233703-A (GB)
IPC: B23Q1/28
Filed: 1967-07-12
Abstract: 1,233,703. Machine tool details. RUTTER TOOLS Ltd. 7 June, 1968 [12 July, 1967], No. 31976/67. Heading B3B. A drilling machine table assembly comprises a table 8 slidable on bars 6, connected to cast aluminium yokes 5, slidable on bars 3, a removable index plate 19 fixed to the underside of the table casting 10, and a pneumatically actuated plunger 29 mounted in an aluminium base 2, which co-operates with holes 23 in the plate 19, so as to provide accurate indexed positions for the table. A metal tray 12 attached to casting 10 provides a surface to which a component drawing can be fixed for co-operation with a pointer 13, so as to provide a course adjusting means for the table. A transparent perspex chip guard 17, and component location strips 18 are provided. A control box 36 is attached to base 2 and includes an air control lever 37, a pneumatic warning indicator 38, a pressure gauge 42, and a pressure regulator valve knob 43. Low pressure air is supplied to the bearings of rods 3 and 6 when plunger 29 is retracted, so as to facilitate easy movement of the table, and the yokes 5 and casting 10 are clamped to the rods 3 and 6 by pads 57, Fig. 3, actuated by the rod 52 of a pneumatic piston 55, and pins 56.
Patent GB-1234114-A (GB)
IPC: B01D33/00
Filed: 1969-06-11
Abstract: 1,234,114. Filter. NIKEX NEHEZIPARI KULKERESKEDELMI VALLALAT. 11 June, 1969, No. 29591/69. Heading B1D. An annular filtering bed of sand is supported between a stack 2 of overlapping annular shutters and synthetic cloth 5, and liquid delivered through ducts 4, 3 filters outwards through the bed to space 6, the liquid being periodically diverted by valve 13 into duct 12 and flowing upwards from distributor 10 to overflow 15, washing the bed and carrying the most contaminated layer of sand through the shutters to settle in space 9. Subsequently an air lift 16, 17 is operated to lift the contaminated sand to the top of the vessel 1 whence it falls back cleaned on to the top of the bed. Filtration flow is then restored. The filter is particularly for water, but wine, oil and petrol are also mentioned. Outlet 8 includes a shut-off valve and inlet duct 4 has a float-operated valve to maintain a constant water level in the vessel 1 during filtration.