Patent SG-11201903770U-A (SG)
Title: Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
Inventor: KEHLER JAN
IPC: A61P25/28
Filed: 2017-10-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 01111H111101111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/078038 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A61K 31/4985 (2006.01) A61P 25/18 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/5377 (2006.01) A61P 25/22 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 31/55 (2006.01) A61P 25/24 (2006.01) A61K 45/06 (2006.01) A61P 25/28 (2006.01) Published: (21) International Application Number: — with international search report (Art. 21(3)) PCT/EP2017/077497 (22) International Filing Date: 26 October 2017 (26.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PA201600659 28 October 2016 (28.10.2016) DK (71) Applicant: H. LUNDBECK A/S [DK/DK]; Ottiliavej 9, 2500 Valby (DK). (72) Inventors: KEHLER, Jan; c/o H. Lundbeck A/S Ottili- avej 9, 2500 Valby (DK). RASMUSSEN, Lars, Kyhn; c/ o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). LANG- GARD, Morten; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). JESSING, Mikkel; c/o H. Lundbeck A/S Ot- tiliavej 9, 2500 Valby (DK). VITAL, Paulo, Jorge, Vieira; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). JUHL, Karsten; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (84) 1-1 ot (54) Title: COMBINATION TREATMENTS COMPRISING IMIDAZOPYRAZINONES FOR THE TREATMENT OF PSYCHIA- en TRIC AND/OR COGNITIVE DISORDERS 0 GP (57) : The present invention provides combination treatments comprising administration of compounds that are PDE1 enzyme 1 r - - inhibitors and other compounds useful in the treatment of psychiatric and/or cognitive disorders such as for example Attention Deficit 0 ---. Hyperactivity Disorder (ADHD), depression, anxiety, narcolepsy, schizophrenia, cognitive impairment or cognitive impairment asso- ciated with schizophrenia (CIAS). Separate aspects of the invention are directed to the combined use of said compounds for the treat- 1-1 © ment of psychiatric and/or cognitive disorders. The present invention also provides pharmaceutical compositions comprising said PDE1 N enzyme inhibitors together with other compounds useful in the treatment of psychiatric and/or cognitive disorders. C