baber/WOPTO huggingface dataset:
Patent CA-2306801-A1 (CA)
Title: Process for the production of n-butanol
Inventor: RYAN DEBRA A
IPC: C07C31/12
Filed: 1998-10-12
Abstract: Disclosed is the use of a Raney cobalt catalyst in the hydrogenation process for the production of n-butanol. A process for the production of purified n-butanol comprising contacting in a hydrogenation zone n-butyraldehyde and hydrogen with an active porous cobalt catalyst under hydrogenation conditions of temperature and pressure for the production of alcohols from aldehydes, either in the substantial absence of water, or in the presence of water in an amount up to about 6 wt. %  based on the weight of the liquid hydrogenation reaction product to produce said reaction product comprising n-butanol, and purifying said reaction product by fractional distillation in the presence of about 0.01 to about 6 wt. % of water, based on the total weight of feed to the fractionating column.
Patent CA-2307698-A1 (CA)
Title: Automatic test connector adapter plate for ab pipe bracket
Inventor: ANDREWS LAWRENCE J
IPC: B60T17/04
Filed: 2000-05-05
Abstract: A test connector adapter plate for use with a pipe bracket portion of a freight brake control valve of a railway freight vehicle and with a portable automated single car brake tester.      The pipe bracket portion having four test ports vertically disposed on a front side of such pipe bracket portion for single car brake testing. These test ports are fluidly connected to passageways within the pipe bracket for communicating fluid pressure with brake pipe, brake cylinder, emergency reservoir and auxiliary reservoir, respectively. A first member of the test connector adapter plate is engagable with the test ports on such front side of the pipe bracket portion for accessing the passageways respectively communicating to brake pipe, brake cylinder, emergency reservoir and auxiliary reservoir and are fluidly connected to respective passageways within the adapter plate. A second member of the test connector adapter plate is a manifold with access ports for providing fluid communication from brake pipe, brake cylinder, emergency reservoir and auxiliary reservoir to test receiver of the portable automated single car brake tester. The manifold of the second member of the adapter plate is directed to provide access on an axis perpendicular to that of the first member of the adapter plate so as to provide at least one of a top and a bottom access for the portable automated single car brake tester.
Patent CA-2308511-A1 (CA)
Title: Use of transfected or transduced mammalian cells for treating bone pathologies
Inventor: EVANS CHRISTOPHER H
IPC: A61K38/20
Filed: 1998-10-29
Abstract: Disclosed is the use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or Herpes Simplex viruses and/or liposomes and/or plasmids as agents which stimulate mammal cells in order to produce therapeutic proteins that act as medicaments on a cellular level for the genetic treatment of bone pathologies.
Patent CA-2309885-A1 (CA)
Title: Recombinant allergen with reduced enzymatic activity
Inventor: JACOBS PAUL
IPC: A61P37/08
Filed: 1998-11-16
Abstract: The present invention provides a novel treatment for allergy comprising the provision of a recombinant allergen with reduced enzymatic activity. Vaccines comprising said mutant allergens stimulate a Th1-type immune response in allergic or naïve individuals, thereby reducing the potential for an allergic response upon contact with wild-type allergen. Preferably said allergen is DerP1.
Patent CA-2310319-A1 (CA)
Title: Derives de 2-pyrrolidinone substitues en position 4, utilises pour reduire le niveau de glutamate extracellulaire
Inventor: KNORLE RAINER
IPC: C07D209/54
Filed: 1998-11-17
Abstract: L'invention concerne des dérivés de 2-pyrrolidinone substitués en position 4 s'utilisant comme principe actif thérapeutique. Etonnamment, on a trouvé que ces composés permettent d'abaisser considérablement le niveau de glutamate extracellulaire. Ces composés s'utilisent de ce fait pour assurer la prophylaxie et le traitement d'une pluralité de maladies, y compris en particulier l'apoplexie cérébrale.
Patent CA-2310426-A1 (CA)
Inventor: PUSKAS JOHN D
IPC: A61B17/32
Filed: 1998-11-18
Abstract: An endoscopic device (8) provides improvements in the endoscopic working space by the use of a semi-tubular hood (3) with an arched top wall, self-supporting sidewalls that allow simultaneous manipulations of dissection, cutting, ligation, retraction, and the like, without requiring constant application of external force. The endoscopic device (8) enhances visualization, and reduces the need for cleaning the endoscopic lens (12).
Patent CA-2310937-A1 (CA)
Inventor: ALFARO CONRAD
IPC: H01H85/54
Filed: 1992-01-29
Abstract: A fused disconnect device constructed according to the present invention comprises a housing, a line side terminal, a load side terminal, a protection fuse holder assembly removably installed in a cavity of said housing, and a separate alarm fuse removably installed in said housing. The alarm fuse may remain installed in the housing regardless of the presence of the protection fuse holder assembly, so that an alarm will be generated whenever the inventive device has interrupted power to the load. The fuse holder assembly comprises a cavity for holding at least one spare protection fuse and one spare alarm fuse. A cover retains the spare fuses in the cavity until they are required. The cover is marked to indicate the fuse ratings while permitting an observer to view the contents of the cavity.
Patent CA-2311042-A1 (CA)
Inventor: PINTER HANS-DIETER
IPC: C25B1/34
Filed: 2000-06-09
Abstract: The invention relates to a process for the electrolysis of sodium chloride-containing brine with parallel operation of amalgam electrolysis units (5) and membrane electrolysis units (4) with a common brine circuit using a mercury-resistant oxygen consumable cathode in the membrane electrolysis unit (4).
Patent CA-2311140-A1 (CA)
Title: Incorporation of supersaturated lactose in process cheese
Inventor: HAN XIAO-QING
IPC: A23C19/082
Filed: 2000-06-02
Abstract: The present invention discloses a method of preparing a process cheese containing lactose wherein the cheese remains free of lactose crystals. The method includes a step in which a dairy liquid is heated at a temperature, and for a duration in time, that are sufficient to inhibit or prevent crystallization of the lactose after formation of the process cheese. The ratio of dairy liquid to cheese is from about 1:1 to about 3:1 by weight. The invention additionally discloses the lactose-containing process cheese stabilized against the formation of lactose crystals, prepared by the process of the invention.
Patent CA-2313194-A1 (CA)
Title: Method for producing salts of cyclic amidines
Inventor: MOST DIETER
IPC: C07D207/22
Filed: 1998-12-07
Abstract: The invention relates to a method for producing salts of cyclic amidines of general formula (I). Known methods for producing salts of compound (I) only produce low yields. According to the invention, the appropriate .omega.-amino-.alpha.-amino acids are selectively protected in the .omega.-amino function. These protected compounds are decarboxylated oxidatively using halogen derivatives and the oxidatively decarboxylated substances are then cyclised with acid being added. This results in better yields of the salts of compound (I).
Patent CA-2315300-A1 (CA)
Title: Insoluble compositions for controlling blood glucose
Inventor: BRADER MARK LAURENCE
IPC: A61K47/02
Filed: 1998-12-22
Abstract: The present invention relates to insoluble compositions comprising a protein selected from the group consisting of insulin, insulin analogs, and proinsulins; a derivatized protein selected from the group consisting of derivatized insulin, derivatized insulin analog, and derivatized proinsulin; a complexing compound; a hexamer-stabilizing compound; and a divalent metal cation. Formulations of the insoluble composition are suitable for both parenteral and non-parenteral delivery for treating hyperglycemia and diabetes. Microcrystal forms of the insoluble precipitate are pharmaceutically analogous to the neutral protamine Hagedorn (NPH) insulin crystal form.  Surprisingly, it has been discovered that suspension formulations of such insoluble compositions possess unique and controllable dissolution properties that provide therapeutically advantageous glucodynamics compared with insulin NPH formulations.
Patent CA-2318035-A1 (CA)
Inventor: JERICEVIC ZELJKO
IPC: E21B47/04
Filed: 1999-11-16
Abstract: L'invention porte sur un procédé de correction de données mesurées par un instrument (3) de diagraphie de sondage de puits du fait des effets de yo-yo du câble (2). Les données sont d'abord prétraitées pour réduire l'importance des composantes de fréquence spatiale des données apparaissant dans une largeur de bande d'accélération axiale de l'instrument (3) de diagraphie des sondages qui correspond au câble (2). Des valeurs propres d'une matrice sont ensuite décalées, sur des intervalles de profondeur où la valeur absolue la plus faible d'une des valeurs propres change de signe, d'une quantité telle que la valeur propre à valeur absolue la plus faible ne change pas de signe. La matrice fait partie d'un système d'équations linéaires à l'aide desquelles les mesures effectuées par l'instrument sont converties en valeurs d'une caractéristique recherchée des formations terrestres. Les artéfacts qui peuvent rester dans les données après l'étape de prétraitement sont sensiblement éliminés par le décalage des valeurs propres.
Patent CA-2318466-A1 (CA)
Inventor: DENG JIANMIN
IPC: F16L51/02
Filed: 1998-10-15
Abstract: A contractible joint device for metal conduit (10), includes an inlet short pipe (1), a short outlet pipe (2) and a casing coupling (3). The opposite inner ends of the said two short pipes (1, 2) are placed in casing coupling (3) with a come-and-go clearance (6) between said inner ends. A corrugation pipe (7) is placed and can be axially moved back and forth by a force in said come-and-go clearance (6). The two ends of the said corrugation pipe (7) are connected respectively with the inner ends of the two short pipes to form a seal, and at least one of the ends of casing coupling (3) is free with relative to two short pipes (1, 2).
Patent CA-2322243-A1 (CA)
Inventor: BENDELLI GIAMPAOLO
IPC: H04J14/00
Filed: 2000-10-04
Abstract: An optical add-drop multiplexer which is tunable within a wide tuning range is provided. The device is based on the use of tunable Bragg gratings (2; 20, 21) which form the means for selecting the carrier or carriers to be inserted and extracted, and optical circulators (1, 3) which form input-output ports for the multiplexed stream to be subjected to the extraction and insertion operations and for the multiplexed flow resulting from this operation, and extraction and insertion ports for the carrier or carriers concerned. The gratings (20; 21) are associated with a phase control element (7) which acts in such a way as to disable the extraction function during a tuning transient
Patent CA-2324016-A1 (CA)
Title: Synthesis of compounds and libraries of compounds
Inventor: MALINKY TIFFANY
IPC: C07D207/16
Filed: 1999-03-22
Abstract: The present invention provides a system for the production of chemical compounds and libraries of compounds that are complex, stereochemically and regioselectively pure, and may mimic the structural or functional properties of a peptide. The invention provides methods for producing collections of peptidomimetic compounds which, in one preferred embodiment, comprises (1) providing two diversifiable monomers containing terminal reactive moieties;  (2) reacting the monomers under conditions that allow for the control of stereochemistry as well as chemoselectivity; and (3) generating diversifiable isolable compounds or libraries of compounds. In another preferred embodiment, a collection of peptidomimetic compounds is provided by (1) providing at least one diversifiable monomer containing terminal reactive moieties; (2) reacting the monomer with a reagent under conditions that allow for the control of stereochemistry as well as chemoselectivity; and (3) generating diversifiable isolable compounds or libraries of compounds. In another broader aspect, the present invention provides for the synthesis of a collection of compounds comprising peptidomimetics and non-peptidomimetics alike having stereodiversity. This method involves the steps of (1) selecting desired synthetic precursors having a predefined stereochemical relationship; (2) reacting the synthetic precursors so that a compound having a specific stereochemistry is obtained; and (3) repeating these steps of selecting and reacting until a desired library of compounds having stereochemical diversity is obtained. In certain preferred embodiments, a library of compounds having only diversity of stererochemistry is provided. In certain other preferred embodiments, a library of compounds having structural diversity and stereochemical diversity is provided. The present invention also provides various chemical compounds useful in the inventive methods for production of complex peptidomimetic libraries. The peptidomimetic and stereodiverse compounds of the inventive method are useful for interactions with receptors in cells and may emulate the structure and functionality of peptides.
Patent CA-2324240-A1 (CA)
Title: Procedure and system for reliable and safe identification of a contracting party
Inventor: VATANEN HARRI
IPC: G06Q10/00
Filed: 1999-03-17
Abstract: The invention relates to a procedure and system for reliable and safe identification of contracting parties via a telecommunication network.  According to the invention, the contracting parties are authenticated e.g. by means of an electronic signature, whereupon a request for verification of the identity of the parties is sent to a reliable third party. The reliable third party sends a confirmation to the counterpart of each contracting party, the identities of the parties being thus verified. In addition, the reliable third party writes a record to a storage database about the verification and the matter it is related to. Thus, a "notarial service" can be a flexibly implemented e.g. using mobile stations.
Patent CA-2325049-A1 (CA)
Title: Mammalian edg-7 receptor homologs
Inventor: GUPTA ASHWANI K
IPC: C12N15/12
Filed: 1998-12-30
Abstract: The present invention is directed to nucleic acid sequence and amino acid sequences for mammalian EDG-7 receptor homologs, and particularly for human EDG-7 receptor homologs. The invention also provides methods for determining agonists and antagonists for EDG-7 receptors in addition to assays, expression vectors, host cells and methods for treating disorders associated with aberrant expression or activity of EDG-7.
Patent CA-2326290-A1 (CA)
Inventor: KNELL TIMOTHY A
IPC: B25H7/04
Filed: 2000-11-20
Abstract: Compositions and methods for laser marking substrates such as metal, glass and ceramic are disclosed. A marking material is applied to the surface of the substrate, followed by irradiation of a portion of the marking material to form a bright, oxidation resistant marking on the substrate. The non-irradiated portion of the marking material is then removed from the substrate. The marking material comprises compounds such as metal salts and metal oxides which, upon irradiation, form oxidation resistant metallic markings. The marking method is highly versatile, can be performed quickly, and produces permanent marks of high resolution and contrast without damage to the substrate.
Patent CA-2333642-A1 (CA)
Title: Systeme de traitement d'informations
Inventor: KAWAHARA HIROKAZU
IPC: G06F21/64
Filed: 2000-03-30
Abstract: Un ordinateur personnel (1) transmet un programme de source, auquel est jointe une signature, à un poste d'authentification par une unité de communication (25). Le poste d'authentification, si aucune modification n'est rencontrée dans le programme de source reçu, chiffre le programme de source avec une clé secrète du poste d'authentification, et il transmet le programme de source chiffré à l'ordinateur personnel (1). L'ordinateur personnel (1) enregistre le programme de source chiffré sur un lecteur de disque dur (21) et le transmet à un adaptateur (26).
Patent CA-2334708-A1 (CA)
Inventor: SZAMEITAT KLAUS
IPC: C25D1/00
Filed: 1999-06-24
Abstract: The invention relates to a galvanic bath, to a method for precipitating chromium onto objects using said galvanic bath, and to the use of this method for producing structured hard chromium layers on machine parts. The galvanic bath contains at least one compound which provides chromium (VI) ions, in an aqueous solution, and comprises a) a quantity of chromium (VI) ions corresponding to 100 to 600 g/l chromic acid anhydride, b) sulphate ions in the form of sulphuric acid and/or a soluble salt thereof, the molar concentration ratio of chromium (VI) ions to sulphate ions (SO42-) being 90:1 to 120:1 and c) a quantity of 2-hydroxyethane sulphonate ions corresponding to 0.01 to 3.0 g/l of the sodium salt.
Patent CA-2341309-A1 (CA)
Title: Use of mcrp for delivery of materials into cells
Inventor: RADOSEVICH JAMES A
IPC: C12Q1/68
Filed: 1999-08-19
Abstract: The invention provides a method of delivering a material into a cell. The method comprises associating the material with a modified C-reactive protein  (mCRP) or a mutant-mCRP. Then, the material associated with the mCRP or the mutant-mCRP is contacted with the cell so that the material is delivered int o the cell. The invention also provides a kit comprising one or more container s. In one embodiment, one of the containers holds a material to be delivered in to a cell in association with a modified C-reactive protein (mCRP) or a mutant- mCRP. Alternatively, one of the containers holds the material to be delivere d into the cell, and a second container holds the mCRP or the mutant-mCRP.</SD OAB>
Patent CA-2342757-A1 (CA)
Inventor: MATSUSHITA MICHIYO
IPC: A41D13/12
Filed: 2001-04-04
Abstract: A disposable gown includes front and rear trunk regions 3, 4. The front trunk region 3 has a first neckline 3d extending transversely and first armhole lines 3e rectilinearly and obliquely extending downward from lateral ends of the first neckline 3d toward respective armpits. The rear trunk region 4 has a second neckline 4d extending transversely and second armhole lines 4e rectilinearly and obliquely extending downward from lateral ends of the second neckline 4d toward the armpits.      A crossing angle .theta.1 between both first extensions X1 generated when the first armhole liner 3 e are extended upward from lateral ends of the first neckline 3d is larger than a crossing angle .theta.2 between the both second extensions X2 generated when the second armhole lines 4e are extended upward from lateral ends of the second neckline 4d. Each of sleeves 5A, 5B is bonded to a basic trunk portion 2 so that each of the first armhole lines 3e of the front trunk region 3 may coincide with a first sleeve bonding line 5a of each of the sleeves 5A, 5B and each of the second armhole lines 4e of the rear trunk region 4 may coincide with a second sleeve bonding line 5b of each of the sleeves 5A,5B.
Patent CA-2343753-A1 (CA)
Title: Spray gun for coating objects
Inventor: BUSCHOR KARL
IPC: B05B7/02
Filed: 1999-06-09
Abstract: A spray gun coating objects with a coating material. Its barrel (2) and its grip (4), at least their basic shapes, are one integral structure (6).
Patent CA-2346879-A1 (CA)
Title: Liposome-entrapped topoisomerase inhibitors
Inventor: COLBERN GAIL T
IPC: A61K31/496
Filed: 1999-10-15
Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 µmole drug per µmole lipid.
Patent CA-2350061-A1 (CA)
Inventor: GREN TORKEL
IPC: A61P1/00
Filed: 1999-11-11
Abstract: A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.
Patent CA-2350454-A1 (CA)
Inventor: FROLOV DMITRY VLADIMIROVICH
IPC: F02P3/12
Filed: 1998-11-12
Abstract: The present invention relates to a method for igniting the air-fuel mixture in an internal combustion engine, wherein said method involves increasing the force of the electric field in the electrode gap of the spark plug until the electric breakdown thereof. The method further involves repeating several times the following steps: decreasing step by step the force of the electric field down to a given level; maintaining the force at this level for a duration of 2.5 to 25 microseconds; reversing the orientation of the electric field; and increasing the force of the electric field in the electrode gap of the spark plug until the electric breakdown thereof. This invention also relates to an ignition system that uses piezoelectric elements for realising this method. This invention provides for an essentially complete fuel combustion and improves the economical and ecological characteristics of the engine.
Patent CA-2352571-A1 (CA)
Title: In vivo biosensor apparatus and method of use
Inventor: APPLEGATE BRUCE M
IPC: G01N33/483
Filed: 1999-12-02
Abstract: Disclosed are bioluminescent bioreporter integrated circuit devices that detect select analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in response to the amount of target analyte present in the body fluids.
Patent CA-2353076-A1 (CA)
Title: Ligation assembly and detection of polynucleotides on solid-support
Inventor: HUNKAPILLER MICHAEL W
IPC: C12Q1/6834
Filed: 1999-08-24
Abstract: The present invention concerns methods of assembly of a polynucleotide on a solid-support by performing steps of annealing, ligation, and extension. The steps may be repeated in a cyclical manner to assemble immobilized double- or single-stranded polynucleotides with functional gene properties. The immobilized polynucleotides may be amplified by the polymerase chain reaction, and detected and quantitated by an exonuclease assay with a self-quenching, fluorescent probe. The polynucleotide may be cleaved from the solid-support by chemical or enzymatic cleavage.