baber/WOPTO huggingface dataset:
Patent CY-1107268-T1 (CY)
Inventor: ZAVADA JAN
IPC: A61K48/00
Filed: 2008-01-16
Abstract: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed.
Patent CY-1108601-T1 (CY)
Inventor: ARMSTRONG DAVID NIGEL
IPC: A61K9/00
Filed: 2008-11-26
Abstract: A topical composition comprising about 5 wt % to about 12.5 wt % of metronidazole or a pharmacologically acceptable salt thereof in a non-aqueous vehicle. The composition may be used in the treatment of skin damage due to inflammatory skin conditions; thermal, chemical or electrical burns; infections or radiation treatment. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect, and thus, side effects observed from systemic administration are avoided.
Patent CY-1112106-T1 (CY)
Inventor: LOER LINDEROTH DORTE
IPC: A61K47/32
Filed: 2011-06-16
Abstract: Stable formulations of PTH that may be administered to animal or human subjects are provided herein. The PTH formulations described herein include PTH, a non-ionic surfactant and, optionally, an antioxidant. The formulations described herein exhibit improved stability relative to compositions of PTH that do not include a non-ionic surfactant or the combination of a non-ionic surfactant and an antioxidant. Also described herein are methods of making and using the PTH formulations described herein.
Patent CY-1112368-T1 (CY)
Inventor: ZAKNOEN SARA
IPC: A61P35/00
Filed: 2012-01-20
Abstract: A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with a camptothecin derivative and one or more chemotherapeutic agents selected from a microtubule active agent; an alkylating agent; an anti-neoplastic anti-metabolite; a platin compound; a topoisomerase II inhibitor; a VEGF inhibitor; a tyrosine kinase inhibitor; an EGFR kinase inhibitor; an mTOR kinase inhibitor; an insulin-like growth factor I inhibitor; a Raf kinase inhibitor; a monoclonal antibody; a proteasome inhibitor; a HDAC inhibitor; and ionizing radiation.
Patent CY-1122732-T1 (CY)
Title: Συνθεσεις για αναπνευστικη χορηγηση δραστικων παραγοντων και συναφεις μεθοδοι και συστηματα
Inventor: VEHRING REINHARD
IPC: A61K31/40
Filed: 2020-02-25
Abstract: Παρέχονται συνθέσεις, μέθοδοι και συστήματα για πνευμονική ή ρινική χορήγηση δραστικών παραγόντων μέσω εισπνευστήρα μετρημένων δόσεων. Σε μία υλοποίηση, οι συνθέσεις εμπεριέχουν μέσο εναιωρήματος, σωματίδια δραστικού παράγοντα, και εναιωρούντα σωματίδια, όπου τα σωματίδια δραστικού παράγοντα και τα εναιωρούντα σωματίδια σχηματίζουν συνεναιώρημα εντός του μέσου εναιωρήματος.
Patent CY-1122951-T1 (CY)
Title: Φαρμακευτικα σκευασματα ενος αναστολεα υδροξυλασης ηιf
Inventor: CONCA DAVID
IPC: A61K9/28
Filed: 2020-04-27
Abstract: Η παρούσα αποκάλυψη αφορά σε φαρμακευτικά σκευάσματα [(4-υδροξυ-1-μεθυλο-7-φαινοξυ-ισοκινολινο-3-καρβονυλ) -αμινο] -οξικού οξέος και σε μεθόδους χρήσης τους.
Patent CY-1123073-T1 (CY)
Title: Μεδοθος λειτουργιας ενος συμπιεστη και μια συσκευη για αυτην
Inventor: VAN DE LISDONK CAROLUS ANTONIUS CORNELIS
IPC: F25J1/02
Filed: 2020-06-24
Abstract: Η παρούσα εφεύρεση παρέχει μέθοδο λειτουργίας ενός συμπιεστή (100) για τη μείωση του φορτίου εκτόνωσης κατά τη διάρκεια ενός συμβάντος αποκλεισμένης εξόδου και μία συσκευή νια αυτήν, όπου η μέθοδος περιλαμβάνει τουλάχιστον τα βήματα: (a) διέλευση ενός ή περισσοτέρων ρευμάτων τροφοδοσίας συμπιεστή (10, 20, 30, 40) προς μία ή περισσότερες εισόδους (18, 28, 38, 48) ενός πρώτου συμπιεστή (100), όπου έκαστο ρεύμα τροφοδοσίας συμπιεστή (10, 20, 30, 40) διέρχεται μέσω μιας βαλβίδας τροφοδοσίας συμπιεστή (12, 22, 32, 42)• (b) συμπίεση του ενός ή περισσοτέρων ρευμάτων τροφοδοσίας συμπιεστή (10, 20, 30, 40) στον πρώτο συμπιεστή (100) ώστε να παρέχεται ένα συμπιεσμένο ρεύμα εκκένωσης (150) στην έξοδο (105) του πρώτου συμπιεστή (100)• (c) παρακολούθηση ενός πρώτου δείκτη ενός συμβάντος αποκλεισμένης εξόδου του πρώτου συμπιεστή (100)• και (d) εντολή κλεισίματος των βαλβίδων τροφοδοσίας συμπιεστή (12, 22, 32, 42) όταν ανιχνεύεται ο πρώτος δείκτης του συμβάντος αποκλεισμένης εξόδου του πρώτου συμπιεστή (100).
Patent HR-P20110859-T1 (HR)
Inventor: GREEN LARRY L
IPC: C12N15/85
Filed: 2011-11-18
Abstract: Protutijelo, ili njegov dio koji se veže na antigen, naznačeni time da se sastoje od varijabilnog lakog lanca čiji je odsječak definiran kao SEQ ID NO:81 i varijabilnog teškog lanca čiji je odsječak definiran kao SEQ ID NO:79. Patent sadrži još 11 patentnih zahtjeva.
Patent SI-1293855-T1 (SI)
Title: Method foe preparing mixed water
Inventor: VOLKER WACK
IPC: E03C1/044
Filed: 2000-12-13
Abstract: Electronic water mixer (1) has an operating unit (3) for input of an operating value and an electronic controller that controls a stepper motor that acts on a mechanical actuator (7) for varying the mixer water volumes. The controller (6) and actuator (7) are made as a single compact unit that is suitable for flush or wall mounting - beneath the plaster. An Independent claim is made for a method for controlling mixer water temperature using the above mixer in which the mixer water volumes are determined in conjunction with a temperature sensor (13) that reads the actual water temperature which can then be compared with the pre-set water temperature.
Patent SI-1642972-T1 (SI)
Title: Therapeutic uses of BR43X2 soluble receptors
Inventor: GROSS JANE A
IPC: C12N15/00
Filed: 2000-01-07
Abstract: There is provided a fusion protein consisting of a first portion and a second portion joined by a peptide bond, wherein said first portion consists of an amino acid sequence selected from: (i) amino acid residues 25-104 of SEQ ID NO: 6; (ii) amino acid residues 34-66 of SEQ ID NO: 6; (iii) amino acid residues 71-104 of SEQ ID NO: 6; and (iv) amino acid residues 34-66 and 71-104 of SEQ ID NO: 6; and said second portion is an immunoglobulin heavy chain constant region. There is also provided an antibody or antibody fragment that specifically binds to a polypeptide selected from SEQ ID NO: 59 or SEQ ID N: 60. There is also provided an antibody or antibody fragment that specifically binds to a ztnf4 polypeptide, for use in treating systemic lupus erythematosus in a mammal.
Patent SI-1536827-T1 (SI)
Title: Use of protein kinase n beta
Inventor: KLIPPEL-GIESE ANKE
IPC: A61K38/00
Filed: 2003-08-10
Abstract: The present invention is related to use of protein kinase N beta or a fragment or derivative thereof as a downstream target of the PI 3-kinase pathway, preferably as a downstream drug target of the PI 3-kinase pathway.
Patent SI-1644238-T1 (SI)
Title: Expandable material
Inventor: KASSA ABRAHAM
IPC: B62D29/00
Filed: 2004-06-23
Abstract: An expandable material and articles incorporating the same are disclosed. The material includes a polymeric admixture; a blowing agent; a curing agent; a tackifier; and optionally, a filler or fiber. There is also disclosed a member (10) for sealing, baffling and/or reinforcing components of an automotive vehicle. The member (10) generally includes a carrier (20), an expandable material (22) and at least one fastener (24).
Patent SI-1635843-T1 (SI)
Title: Therapy comprising dienogest for hormone replacement and depression
Inventor: RUDOLPH INA
IPC: A61K31/00
Filed: 2004-06-25
Abstract: The treatment and/or prevention of depression by the co-administration of an estrogen with the progestin dienogest for HRT and/or contraception.
Patent SI-1861912-T1 (SI)
Title: Fan unit, particularly for a vacuum cleaner
Inventor: BARTSCH KLAUS
IPC: H02K7/00
Filed: 2006-02-23
Abstract: A vacuum cleaner fan with an electric drive motor having a stator assembly and a rotor. The stator assembly and rotor are disposed in a bearing pot. An at least single-stage fan unit is driven by the electric motor. The fan unit includes a guide stage, a suction cap, and an impeller that is configured to generate an air stream. The bearing pot includes a receiving pocket which holds an adapter housing. The adapter housing accommodates a printed circuit board. A power semiconductor operable to control rotational speed of the fan unit is included on the printed circuit board. At least a portion of the power semiconductor protrudes from the adapter housing into the vicinity of the air stream generated by the fan unit.
Patent SI-1934058-T1 (SI)
Title: Method for binding a bundle of loose leaves or the like and binding element, end leaf or cover applied thereby
Inventor: PELEMAN GUIDO
IPC: B42D1/00
Filed: 2006-10-02
Abstract: Method for binding a bundle of loose leaves or the like in a cover. The method includes the step of providing an end leaf that includes a fixing strip on a side edge, with the fixing strip partly fixed to the end leaf and provided with a strip of glue on a part of the fixing strip which is not fixed to the end leaf. On the side of the fixing strip turned away from the end leaf, said strip of glue being provided with a removable foil. Another step is binding a free edge of the bundle of loose leaves together with the end leaf. Further steps include removing the foil, and providing the bound edge of the bundle of leaves and the end leaf in the back of the cover and fixing thereof in the cover only by the strip of glue.
Patent SI-1833647-T1 (SI)
Title: Clamping assembly for woodworking knife
Inventor: GOUIN MATHIEU J A
IPC: B27L11/00
Filed: 2006-01-05
Abstract: A clamping assembly to hold a woodworking knife in place in a woodworking machine. The clamping assembly comprises a clamping component comprising a body and an actuator. The body has three discrete contact positions distributed thereon: 1) a fulcrum located generally at one end, 2) a knife abutting portion located generally at the other end, and 3) a bearing surface located elsewhere. The actuator is for applying a clamping force to the body along a clamping axis located intermediate of the knife abutting portion and the fulcrum. The fulcrum is a surface having a normal that is at an angle to the clamping axis. The bearing surface is a surface wherein a line normal to the bearing surface intersects the Hoe normal to the fulcrum at a position outside of the clamping component at a location farther askew of the clamping axis than the fulcrum.
Patent SI-2056845-T1 (SI)
Title: Structure and use of 5' phosphate oligonucleotides
Inventor: HORNUNG VEIT
IPC: C12N15/00
Filed: 2007-08-08
Abstract: Oligonucleotides bearing free, uncapped 5' phosphate group(s) are recognized by RIG-I, leading to the induction of type I IFN, IL-18 and IL-1β production. Bacterial RNA also induces type I IFN production. 5' phosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN and/or IL-18 and/or IL-1β production,  in vitro  and  in vivo  and for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. Single-stranded 5' triphosphate RNA can be used for inducing an anti-viral response, an anti-bacterial response, or an anti-tumor response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in a target cell-specific manner.
Patent SI-2231633-T1 (SI)
Title: Antitumoral compounds
Inventor: RODRIGUEZ VICENTE ALBERTO
IPC: A61K31/00
Filed: 2008-12-19
Abstract: A compound of general formula (I)   
wherein A, Y, W, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6  take various meanings for use in the treatment of cancer.
Patent SI-2970284-T1 (SI)
Title: Crystalline cis-(e)-4-(3-fluorophenyl)-2',3',4',9'-tetrahydro-n,n-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro(cyclohexane-1,1'(1h)-pyrido(3,4-b)indol)-4-amine
Inventor: GRUSS MICHAEL
IPC: C07D471/00
Filed: 2014-03-14
Abstract: The present invention relates to crystalline forms of cis-(E)-4-(3-Fluorophenyl)-2',3',4',9'- tetrahydro-N,N-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1, 1 '[1 H]- pyrido[3,4-b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for making the crystalline forms.
Patent TR-200708577-T1 (TR)
Title: Ayrı çift ısı eşanjör tipinde sıcak su kazanı.
Inventor: CHOI YOUNG-HWAN
IPC: F24H1/16
Filed: 2006-02-21
Abstract: Mevcut buluşun sıcak su kazanı; bir egzoz davlumbazına (20), alev borularına (38) ile bir ısı değişim bobinine (60) sahip olan bir ısı değişim birimine (30) ve bir yanma odasına (50) ayrılabilecek şekilde kurulmuştur böylece kazanın paketlenmesi ve taşınmasını kolaylaştırmıştır. Ayrıca; bir üst su bölmesi ile bir alt su bölmesi, ayrı ayrı olarak ve sırasıyla ısı değişim birimi (30) ile yanma odasında (50) temin edilmişlerdir ve mevcut buluş; kullanma suyunun basıncının, su basıncına dayanabilen üst su bölmesine uygulandığı ancak su basıncına dayanıklı olmayan alt su bölmesine uygulanmadığı şekilde kurulması ile teknikte bulunan kazanın alt kısmının su basıncından zarar gördüğü bir sorunu çözer.
Patent DE-3588249-T2 (DE)
Inventor: BLUMBERG SHMARYAHU
IPC: C07K14/65
Filed: 1985-08-09
Granted: 2004-05-06
Abstract: The invention relates to a method of producing a human growth hormone having the amino acid sequence of naturally occurring human growth hormone which comprises   a) producing in a microbial host a first polypeptide which is characterized by the presence of one or more additional amino acids at the N-terminus of the amino acid sequence of naturally occurring human growth hormone; b) contacting the first polypeptide so produced with an enzyme, preferably an aminopeptidase, so as to produce a second polypeptide having the amino acid sequence of naturally occurring human growth hormone; and   c) recovering the second polypeptide so produced.   A preferred microbial host is a bacterium, especially E. coli.
Patent DE-3650531-T2 (DE)
Inventor: RAMSEY III MAYNARD
IPC: A61B5/022
Filed: 1986-07-04
Granted: 1996-11-21
Abstract: A blood pressure cuff is applied about a subject's artery, and inflated above the systolic level thus fully occluding the artery for a full heart cycle. The cuff pressure is thereafter reduced to permit an increasing flow through the progressively less occluded artery, and a measure of the peak amplitudes of the successively encountered blood flow (oscillatory complex) pulses stored in memory. Also retained is the cuff pressure obtaining for each stored complex peak. In accordance with varying aspects of the present invention, the stored complex peak-representing data ensemble is corrected for aberrations; and improved data processing operates on the stored (and advantageously corrected) pulse peak data and the corresponding cuff pressure information to determine the subject's diastolic arterial blood pressure.
Patent DE-3688408-T2 (DE)
Inventor: BUGGERT JERROLD
IPC: G06F13/12
Filed: 1986-01-06
Granted: 1993-08-26
Abstract: A peripheral controller (data link processor) controls data transfers between a host computer and a plurality of tape peripheral units and a single printer peripheral unit. A master microprocessor commands three subordinate controllers to permit concurrent data transfers through a buffer memory in both the Read and the Write directions. A dual channel control from the master microprocessor actuates a DMA switch so that data transfers to/from the tape units can be controlled by switching on alternate control lines which regulate the data transfer operations.
Patent DE-3855325-T2 (DE)
Inventor: FISHER ABRAHAM
IPC: A61K38/04
Filed: 1988-10-26
Granted: 1996-10-10
Abstract: Novel spiro-oxathiolane/quinuclidine compounds correspond with the schematic structural formula (I) <CHEM> and geometrical isomers, enantiomers, diastereoisomers, racemates and acid addition salts thereof, wherein one of Y and Z is O and the other is S (=O)n; n is 0, 1 or 2; R min  and R sec  are each selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, aminoalkyl, C3-7 cycloalkyl, aryl, diarylmethylol and alkyl substituted by at least one aryl group, provided that at least R min or R sec  is other than hydrogen; and each X is hydrogen, or when Y is O and Z is S(=O)n simultaneously, then each X may also be selected from the group consisting of deuterium and tritium, and provided further that when each X is hydrogen, Y is O and Z is S simultaneously, then at least one of R min and R sec  is selected from the group consisting of alkenyl, alkynyl, cyclopropyl, cyclobutyl, cycloheptyl, hydroxyalkyl and aminoalkyl. These compounds are useful for manufacturing therapeutic and diagnostic agents applicable to disorders of or relating to the central nervous and cholinergic systems.
Patent DE-3873066-T2 (DE)
Inventor: BOTTIROLI UGO
IPC: C12Q1/10
Filed: 1988-02-04
Granted: 1992-12-03
Abstract: The invention concerns a method for identifying immediately Salmonellae and distinguishing them from other bacteria by employing a reagent consisting of a 4-methylumbelliferone ester of an acid with 7-10 carbon atoms and a process for preparing said reagent.
Patent DE-3889975-T2 (DE)
Inventor: SATO YUJI
IPC: A61K39/00
Filed: 1988-06-17
Granted: 1995-01-05
Abstract: A Bordetella pertussis variant which produces a pertussis toxin mutant protein partially devoid of subunits. When the variants of the present invention are cultured, a pertussis toxin mutant protein partially devoid of subunits, particularly at least subunit S1, can be harvested from the culture. The thus-obtained pertussis toxin mutant protein partially devoid of subunits can be applied to the preparation of a pertussis vaccine by a conventional method.
Patent TR-199901157-T2 (TR)
Inventor: CLOUGH MARTIN STEPHEN
IPC: A01N43/58
Filed: 1997-11-06
Abstract: Haserelerin, bir dayaniklilik derecesi gelistirdikleri, ilk intektisid olarak aktif bir madde, intektisid olarak etkisiz bir tasiyici ya da seyreltici, tercihe bagli olarak bir ya da birçok yüzey aktif madde içeren bir intektisid bilesimi olup, özelligi, bilesimin, bunlardan baska, yeterli miktarda formül (I) ihtiva etmesidir; ve haserelere karsi savasmak için böyle bir bilesimin uygulanma yöntemi.
Patent AT-E548608-T2 (AT)
Inventor: ROSSI FABIO
Filed: 2008-12-03
Granted: 2012-03-15
Abstract: The finding concerns heating apparatuses such as pellet-fired stoves and thermostoves, characterised in that they have three spaces arranged side-by-side and aligned in the horizontal direction. The three main components of the apparatus, i.e. the fuel-loading tank, the combustion chamber and the smoke aspirator, are arranged inside said spaces.
Patent DE-60006787-T2 (DE)
Inventor: VISSER BAREND
IPC: C01B13/11
Filed: 2000-02-24
Granted: 2004-09-30
Abstract: A field effect transistor (FET) (38) comprising a gate (39) is driven by means of charge storage means (34) and switching means (36) connected in a circuit to the gate of the FET to apply a charge pulse to the gate so as to switch the FET from an off state to an on state. The duration of the pulse is such that the pulse is substantially complete prior to the onset of current flow through the FET. Alternatively, the charge storage means (34) and the switching means (36) are connected in a circuit to the gate of the FET to apply from the charge storage means to the gate a charge pulse (51) driving a voltage on the gate beyond (53) a maximum voltage rating of the FET. <IMAGE>
Patent DE-60020580-T2 (DE)
Inventor: SOUZA J
IPC: A61P37/00
Filed: 2000-08-31
Granted: 2006-04-27
Abstract: The present invention provides methods and compositions for treating auto-immune disease. The methods of the present invention comprise administering to a mammal diagnosed with an auto-immune disease a synergistic ratio of (i) an agent that regulates ICAM-LFA-1 interaction, and (ii) an agent that regulates CD40-CD40 ligand interaction. The compositions of the present invention comprise a synergistic ratio of (i) an agent that regulates ICAM-LFA-1 interaction, and (ii) an agent that regulates CD40-CD40 ligand interaction.
Patent DE-60021381-T2 (DE)
Inventor: BLOKHIN V
IPC: A61K38/00
Filed: 2000-04-27
Granted: 2006-05-24
Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
Patent DE-60021898-T2 (DE)
Inventor: STASIAK MARCIN
IPC: A61K31/551
Filed: 2000-09-01
Granted: 2006-05-24
Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:  wherein A, R1, R2, R2a, R3, R3a and R4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
Patent DE-60022639-T2 (DE)
Inventor: HASEGAWA MAKOTO
IPC: B41M5/00
Filed: 2000-02-10
Granted: 2006-06-29
Abstract: An additive which can improve the water resistance of a water-soluble dye with which an article has been dyed; and an ink-jet recording medium which contains the additive, is exellent in the water resistance and resolution of characters or images recorded thereon, and is suitable for multicolor recordeng. The additive is obtained by reacting a secondary amine, ammonia, an epihalohydrin, and a crosslinking agent as essential ingredients. The recording medium is obtained by causing the additive to be present on a surface and/or inner part of a base.
Patent DE-60036417-T2 (DE)
Inventor: PICCHI ANGELO
IPC: G06Q20/00
Filed: 2000-07-04
Granted: 2008-06-12
Abstract: 1) Process to carry out on-line goods or services purchasing transaction utilising an International network to exchange information and data, wherein a purchaser selects the good and/or services in a web of an e commerce company characterised in that the Purchaser will pay the sum due for the transaction in a second time by using debit or credit cards provided and operating with a Personal Identification Number (PIN) typically bankey card, bancomat and some other credit cards of this kind as collectively called bancomat, that there is not transfer of any secret information about credit or debit card between the Purchaser and the e commerce company web and that an intermediate entity (IM) is built to operate between affiliate e commerce companies supplied with IM's software and the secure network available for the bank system only (SSB), involved in most banking transactions, including bancomat transactions.