Patent AU-2012238318-B2 (AU)
Title: Cyclodextrin complexation methods for formulating peptide proteasome inhibitors
Inventor: LEWIS EVAN
IPC: C07K5/00
Filed: 2012-09-13
Granted: 2014-02-13
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/169282 Al 14 November 2013 (14.11.2013) W I P 0 I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 38/55 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US2012/055127 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 13 September 2012 (13.09.2012) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/644,122 8 May 2012 (08.05.2012) US (84) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except US): ONYX kind of regional protection available): ARIPO (BW, GH, THERAPEUTICS, INC. [US/US]; 249 E. Grand Avenue, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, San Francisco, California 94080 (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors; and TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (75) Inventors/Applicants (for US only): LEWIS, Evan EES,MK, F, NL, G , R, H, RG, IS, IT, LT, LU, LV, [US/US]; 631 Miller Ave, Pacifica, California 64044 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, SHWONEK, Peter [US/US]; 436 Capistrano Ave, San TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Francisco, California 94112 (US). DALZIEL, Sean ML, MR, NE, SN, TD, TG). [AU/US]; 400 Beale Street, Apt. 1901, San Francisco, Declarations under Rule 4.17: California 94105 (US). JUMAA, Mouhannad [US/US]; - as to applicant's entitlement to apply for and be granted a 363 Catamaran St, Foster City, California 94404 (US). patent (Rule 4.17(ii)) (74) Agents: KENDALL, John T. et al.; Fish & Richardson, - as to the applicant's entitlement to claim the priority of the P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 earlier application (Rule 4.17(iii) (US). [Continued on next page] (54) Title: CYLODEXTRIN COMPLEXATION METHODS FOR FORMULATING PEPTIDE PROTEASOME INHIBITORS 0 5 10 15 20 25 Time (hours) (57) Abstract: This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibit O ors and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration. Many peptide proteasome inhibitors have been shown to have low solubility in water. W O 2013/169282 A 1l I |I|Il||llIII ll||||||||II ||D|I |||||||||||I|I||||||||I|||||||||I Published: - with international search report (Art. 21(3))