baber/WOPTO huggingface dataset:
Patent DE-69121940-D1 (DE)
Inventor: MOCHIDA EI
IPC: C07D417/12
Filed: 1991-02-22
Granted: 1996-10-17
Abstract: The present invention relates to pharmaceutical compositions containing at least one of hydantoin derivatives as hypoglycemic as well as hypolipidemic agents. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1 - position of the hydantoin skeleton. The compounds of the present invention represent a satisfactory hypoglycemic as well as hypolipidemic activity. These compounds are extremely useful for the treatment and/or prevention of diabetes mellitus with or without hyperlipidemia. It is indicated that the compounds of the present invention are useful for the treatment and/or prevention of diabetic complications such as somatic or autonomic neuropathy, cataract, retinopathy, nephropathy or microangiopathy. It is also indicated that the compounds of the present invention are useful for the treatment and/or prevention of hyperlipidemia.
Patent DE-69128228-D1 (DE)
Inventor: GULICK DALE E
IPC: G06F13/12
Filed: 1991-08-06
Granted: 1998-01-02
Abstract: A communication system provides communication over a serial bus between a microprocessor and an external device which includes a plurality of registers. The communication system includes a message generator within the microprocessor for generating unique register access messages which provide fast and efficient register access. The external device also includes a message generator which generates register access error messages and interrupt messages.
Patent DE-69128891-D1 (DE)
Inventor: CURRAN STEVEN P
IPC: B02C9/04
Filed: 1991-11-19
Granted: 1998-03-12
Abstract: Apparatus and a method is disclosed for processing wheat to produce white flour by substantially removing the bran layer from the endosperm and germ portions of the wheat grain and grinding the resulting wheat product to a relatively fine state in a roll and classification train that is much simpler than prior milling equipment. Thirteen grinds with intermediate sifting are replaced with one flattening and four grinding stations and three sifts. The initially tempered wheat is passed between spaced, smooth surfaced compression rolls which flatten the wheat grains and then directed between corrugated spiral breaking rolls rotated at different rotational rates with each roll having at least 20 surface corrugations per circumferential inch. The comminuted product is then directed between corrugated spiral grinding rolls rotated at different rotational rates and each having at least 26 corrugations per circumferential inch. After selective classification through mesh sieves, the comminuted wheat is further reduced in size by passage between corrugated spiral reduction rolls having at least about 36 corrugations per circumferential inch which are also rotated at differential rotational rates. The final flour is produced by directing the comminuted product between smooth surfaced finishing rolls rotated at different rates of rotation.
Patent DE-69129428-D1 (DE)
Inventor: CAILLE JEAN-CLAUDE
IPC: C07D403/10
Filed: 1991-07-04
Granted: 1998-06-25
Abstract: The invention relates to the products: <IMAGE>  in which:  R1 = alkyl, alkenyl, alkynyl, alkylthio,  R2B and R3B representing:  - hydrogen, mercapto, formyl, acyl, carboxy, nitro, cyano,  - PO3(R)2, R representing hydrogen, alkyl, aryl, amino or carbamoyl,  - the radicals R4B; - S(O)nR4B; <IMAGE> n = 0 to 2  X = aryl R4B either represents -(CH2)m1-S(O)m2-X-R10, m1 = 0 to 4, m2 = 0 to 2  either m1 is other than 0 and X-R10 represents amino, or whatever the value of m1, X represents single bond or -NH-, -NH-CO-, -NH-CO-NH-,  R10 = alkyl, alkenyl or aryl  or represents hydrogen, alkyl, alkenyl, alkynyl, acyl or amino, - -S-S-R4B', R4B' represents R4B except for amino and alkoxy, and one of R2B and R3B represents -OR4B;  - -S(O)nR4B; <IMAGE> or -S-S-R4B'  m = 0 to 2,  YB = -Y1B-B-Y2B,  Y1B is aryl, B = single bond or -CO-, -O-, -NH-CO-, -CO-NH-, -O-(CH2)p-, p = 1 to 3, Y2B represents hydrogen, cyano, carboxy; in all the isomeric forms and the salts; and to their use as medicaments.
Patent DE-69133204-D1 (DE)
Title: Gereinigtes thermostabiles nukleinsäure-polymeraseenzym aus thermotoga maritima
Inventor: GELFAND H
IPC: C12Q1/68
Filed: 1991-08-13
Granted: 2003-04-10
Abstract: A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight as determined by gel electrophoresis of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with primers and nucleoside triphosphates in a temperature-cycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
Patent DE-69203662-D1 (DE)
Inventor: MATUMOTO SIGERU
IPC: B25J19/00
Filed: 1992-03-12
Granted: 1995-08-31
Abstract: The present invention relates to a balance weight mounting apparatus for a tire wheel 14 by which a balance weight 16 can be automatically mounted on the tire wheel 14. A six-axes manipulator 28 has a weight holder 32 and hammer head 34 provided at the distal end of the arm 26 thereof. The weight holder 32 and the hammer head 34 can be moved by the operation of the manipulator 28 to the location to which a balance weight 16 is fed by a parts feeder 24 and also can be moved within the plane perpendicular to the circumferential direction of a tire wheel 14 supported by a tire wheel support unit 18. The balance weight 16 of a predetermined weight fed by the parts feeder 24 is gripped by the weight holder 32, abutted against that portion of the rim 20, on which this balance weight 16 is to be mounted, of the tire wheel 14 supported by the tire wheel support unit 18, and then mounted thereon by being driven by the hammer head 34. <IMAGE>
Patent DE-69204104-D1 (DE)
Inventor: VAN DER VEEN JAN
IPC: B65D45/32
Filed: 1992-05-05
Granted: 1995-09-21
Abstract: A metal can (1), comprising a bottom (2) and a standing wall (3) which is connected thereto and whereof the zone remote from the bottom comprises an outwardly extending bead (4) having in cross section a first part (5) extending through about 360 DEG , a second part (6) lying against the first part and extending through about 90 DEG -120 DEG  and a third part (7) connecting thereto with a considerably smaller radius of curvature. The object of the invention is to improve as much as possible the reliability of the closure. Since it is known that a bead tends to continuously deform, the invention proposes means for preventing this tendency so that a can once closed in the manner described preserves its tightly closed state. With a view hereto the invention provides a can of the type described which has the feature that the first part is pressed inward in its peripheral zone lying furthest to the outside. <IMAGE>
Patent DE-69205577-D1 (DE)
Inventor: OTTERSTEDT JAN-ERIK
IPC: C09C3/00
Filed: 1992-03-12
Granted: 1995-11-23
Abstract: The invention relates to a pigment having a composite structure. It is characterized in that it comprises a core (1) which has been covered by one or more layers (2) of colorants, which optionally each in their turn have been covered by an optically transparent film (3) which is insoluble or partly insoluble in water or organic solvents. The invention includes also a process for the production of the pigment.
Patent DE-69226197-D1 (DE)
Inventor: ANDERSON DAVID
IPC: A61K47/48
Filed: 1992-11-06
Granted: 1998-08-13
Abstract: A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.
Patent DE-69230446-D1 (DE)
Inventor: MECHOULAM RAPHAEL
IPC: A61P25/28
Filed: 1992-09-11
Granted: 2000-01-20
Abstract: The invention relates to novel compounds of formula (I) wherein R is a hydrogen atom or a C1-C5 alkyl group and R<2> is selected from the group consisting of: (a) a straight-chained or branched C5-C12 alkyl radical; (b) a group -O-R<4>, wherein R<4> is a straight-chained or branched C2-C9 alkyl radical which may be substituted at the terminal carbon atom by a phenyl group; (c) a group -(CH2)n-O-alkyl, wherein n is an integer of from 1 to 7 and the alkyl group contains from 1 to 5 carbon atoms, having the (3S,4S) configuration, essentially free of the (3R,4R) enantiomer. The invention also relates to process for the preparation of compounds of formula (I) as defined above. The invention further relates to pharmaceutical compositions which possess analgesic, anti-inflammatory, anti-emetic, anti-glaucoma, leukocytes antiadhesion or PAF activity, containing as active ingredient compounds of formula (I) as defined above.
Patent DE-69233195-D1 (DE)
Inventor: GANDY SAMUEL E
IPC: A61K31/47
Filed: 1992-12-17
Granted: 2003-10-16
Abstract: Agents which modulate or affect the intracellular trafficking and processing of proteins in the mammalian cell can be utilized to affect the trafficking and processing of APP, thereby inhibiting production of Alzheimer type amyloidosis. Particularly useful agents are chloroquine and its related derivatives such as primaquine.
Patent DE-69302793-D1 (DE)
Inventor: CORSI GIORDANO BRUNO
IPC: C07B63/02
Filed: 1993-10-04
Granted: 1996-06-27
Abstract: A process for the preparation of sterile sodium amoxycillin characterized by the fact that a solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C2-C5 alcohol is reacted in a sterile ambient, optionally in the presence of a suitable amine, with a solution of a suitable salifying agent selected in the group consisting of an alcoholate or carboxylate of sodium in methyl acetate followed by separation of the precipitate is described.
Patent DE-69303812-D1 (DE)
Inventor: TOBEY STEPHEN
IPC: A23L1/308
Filed: 1993-02-16
Granted: 1996-08-29
Abstract: The present invention is directed to a baked food composition comprising food ingredients and a water-soluble cellulose ether which is useful for reducing the low-density lipoprotein serum cholesterol level of an animal. Use of a specific particle-size distribution of the water-soluble cellulose ether results in compositions which are more palatable than known compositions.
Patent DE-69305239-D1 (DE)
Inventor: ZAWADKE THOMAS
IPC: E06C5/02
Filed: 1993-06-08
Granted: 1996-11-14
Abstract: A fire fighting vehicle presenting, on its roof, a frame for elongated objects, in particular, ladders. A frame of the known type, extending along the length of the vehicle's roof, for the transport of elongated objects, in particular, ladders, enables retrieval of said object only from the roof of the vehicle with all connected dangers and high effort on the side of the operators. A frame (2) is provided for on the vehicle's roof, presenting a two-element slide which may be caused to slide along longitudinal guide rails (3), rigidly connected with the vehicle's roof. Ladder (4) weighs on rear slide element (9), whereby said ladder (4), along with said slide, may be manually displaced, brought to a stop and locked in an upward toggle position, wherein said ladder is ready to be used either directly or after positioning in the operational area.   <IMAGE>
Patent DE-69316625-D1 (DE)
Inventor: SCHMITZ CHRISTOPH NMN
IPC: B65H20/24
Filed: 1993-11-04
Granted: 1998-02-26
Abstract: The invention relates to a method of manufacturing an absorbent article, wherein the speed of a part of a continuously moving web comprising a topsheet, backsheet, core or any combination thereof, is periodically varied, while maintaining a constant speed of the upstream and downstream parts of the web. The method comprises feeding the web past rotating transport rollers which are oscillated parallel to the web in the direction of transport and opposite to the direction of transport. Three web sections are during oscillation of the transport rollers maintained in a mutually parallel relationship. Translation- and rotation balancing means allow the transport rollers to be driven at high speeds and low variations in torque. The strain exerted on the web remains relatively low and is limited to the inertia forces that act on the web. <IMAGE>
Patent DE-69324046-D1 (DE)
Inventor: VALENTI PIERA
IPC: A61Q11/00
Filed: 1993-12-15
Granted: 1999-04-22
Abstract: PCT No. PCT/EP93/03571 Sec. 371 Date Oct. 11, 1995 Sec. 102(e) Date Oct. 11, 1995 PCT Filed Dec. 15, 1993 PCT Pub. No. WO94/13318 PCT Pub. Date Jun. 23, 1994The present invention relates to a topical protein preparation to be used for the therapy of periodontitis and diseases of the teeth and of the tissues of the oral cavity, comprising a mixture of transferrin with at least one protein selected from albumins, lysozymes, protease inhibitors, and mixtures thereof.
Patent DE-69325026-D1 (DE)
Inventor: FLYNN STEPHEN JOHN
IPC: H05K3/46
Filed: 1993-06-30
Granted: 1999-06-24
Abstract: An RF waveguide signal transition apparatus for minimizing leakage at RF frequency is described which consists of providing a plurality of plated through-holes (16) of blind holes in a circuit board (10). The plated holes (16) are disposed on the circumference of a circle around the RF waveguide to microstrip transition of probe (14) and each of the plated holes (16) is connected to a ground plane (24). The size of distribution of the plated holes provides a barrier to signal leakage at RF frequencies in the range 10.95-11.7 GHz and they also provide a transition impedance similar to the 50 ohm characteristic impedance providing satisfactory matching and minimizing leakage into the board. The apparatus can also be used to minimise leakage from microstrip to microstrip transitions passing through the circuit board.
Patent DE-69326046-D1 (DE)
Inventor: CHIOU SHANG-JAW
IPC: C08J5/00
Filed: 1993-07-08
Granted: 1999-09-23
Abstract: A process for preparing large dimension emulsion polymer particles and the polymer products of the process are disclosed. In one embodiment, the invention provides particles having a high aspect ratio, having a shape described by a long axis and an intersecting short axis. These particles range in shape from egg-like, through rod-like, up to extended filaments. In another embodiment, the invention relates to large, nearly spherical emulsion polymer particles. <IMAGE>
Patent DE-69400282-D1 (DE)
Inventor: GHILARDI MAURO
IPC: B65H31/24
Filed: 1994-02-11
Granted: 1996-08-14
Abstract: The apparatus for transferring individual articles (M) in sheet form and placing them in stacks (P1, P2) of pre-determined numbers includes a conveyor (17, 23) which picks up the articles from a delivery system (11) by gripping them along their edges. Along said conveyor at least two reciprocating expellers (27, 29) disposed in series remove said articles from the conveyor and lay them down onto a stacker means (31, 35; 33, 37). Each expeller (27, 29) operates with continuous, reciprocating motion at all times. The expeller (27) which is closest to the delivery system (11) may selectively be moved, in the direction of its reciprocating motion, so as to take a position (27X, 27Y) in the trajectory of the manufactured articles fed by said conveyor means, and, alternately, a position (27X', 27Y'), in which it is not in the article-feeding trajectory. <IMAGE>
Patent DE-69408910-D1 (DE)
Inventor: SITGES MENENDEZ FRANCISCO JAVI
IPC: C25C7/02
Filed: 1994-04-08
Granted: 1998-04-16
Abstract: A cathode for the electrolytic deposition of non-ferrous metals, consisting of a plate (1) which, starting from one at least one of its vertical edges, is provided on both sides with coinciding zones (5) of dielectric material situated at the height of impingement of a number of penetrators which cause the upper edge of the deposited layers of zinc to detach. The plate (1) is provided with a slot (7), coinciding with said regions of dielectric material, which is occupied by a flat piece (5) of dielectric material, equal in thickness to the plate (1) and with surfaces which are flat and coplanar with those of said plate (1). The piece (5) and the slot (7) are provided with means of preventing the movement of said piece in any direction. <IMAGE>   <IMAGE>
Patent DE-69411716-D1 (DE)
Inventor: PACE-ASCIAK CECIL R
IPC: C07D331/02
Filed: 1994-03-28
Granted: 1998-08-20
Abstract: Compounds of the general structure   <IMAGE>   are disclosed, wherein X is O, Cn, NH, or S, wherein n is 1, 2, 3 or 4; R1 is OH, CH3, CH2OH, N3 or CH2N3; R3 is H or CH3; R5 is Y-R2, wherein Y is a six-carbon chain optionally containing up to three double or triple bonds or a mixture of double and triple bonds up to a maximum of three; R2 is C1-C10 alkyl OH, C1-C10 alkyl N3 or COOR4, wherein R4 is H, a branched or unbranched C1-C10 alkyl (including substituted alkyl radicals), cycloalkyl, preferably C5 or C6 cycloalkyl, or a five- or six-membered aryl radical (including substituted aryl radicals), i.e. R2 is COOH or an ester of R4; R6 is a seven-carbon chain optionally containing up to three double or triple bonds or a mixture of double and triple bonds up to a maximum of three; and . . . . . . indicates a single, double or triple bond. The compounds are analogs of hepoxilins and are used to modulate hepoxilin activity, for example in the control of inflammation or other processes mediated by intracellular calcium levels.
Patent DE-69413240-D1 (DE)
Title: 5-arylindolderivate
Inventor: MACOR JOHN
IPC: A61P3/04
Filed: 1994-07-04
Granted: 1998-10-15
Abstract: wherein A, B, D, E, and F are each independently nitrogen or carbon; R1 is hydrogen, C1 to C6 alkyl, -(CH2)nR7, or C1 to C3 alkyl-aryl; R2, R3, R4, R5 and R6 are each independently hydrogen, C1 to C6 alkyl, aryl, C1 to C3 alkyl-aryl, halogen, cyano, nitro, -(CH2)mNR8R9, -(CH2)mOR9, -SR8, -SO2NR8R9, -(CH2)mNR8SO2R9, -(CH2)mNR8CO2R9, -(CH2)mNR8COR9, -(CH2)mCONR7R9, or -(CH2)mCO2R9; R2 and R3, R3 and R4, R4 and R5, and R5 and R6 may be taken together to form a five- to seven-membered alkyl ring, a six-membered ary ring, a five- to seven-membered heteroalkyl ring, having 1 heteroatom of N, O, or S, or a five- to six-membered heteroaryl ring having 1 or 2 heteroatoms of N, O, or S; R7is -OR10, -SR10, -SO2NR10R11, -NR10SO2R11, -NR10CO2R11, -NR10COR11, -CONR10R11, or -CO2R10; R8, R9, R10 and R11 are each independently hydrogen, C1 to C6alkyl, or C1 to C3 alkyl-aryl; m is 0, 1, or 2; n is 2, 3, or 4; and the above aryl groups and the aryl moieties of the above alkyl-aryl groups are each independently phenyl or substituted phenyl, wherein said substituted phenyl may be substituted with one to three of C1 to C4 alkyl, halogen, hydroxy, cyano, carboxamido, nitro, or C1 to C4 alkoxy, and the pharmaceutically acceptable salts thereof. These compounds are useful in treating migraine and other disorders and are new. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain, and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.
Patent DE-69429299-D1 (DE)
Inventor: HAGAN RUSSELL MICHAEL
IPC: A61K31/407
Filed: 1994-03-17
Granted: 2002-01-17
Abstract: The present invention relates to the use of certain tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis.
Patent DE-69429626-D1 (DE)
Inventor: BURCZAK D
IPC: C12Q1/689
Filed: 1994-08-18
Granted: 2002-02-14
Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.
Patent DE-69431111-D1 (DE)
Inventor: FINN JAMES
IPC: C05F17/02
Filed: 1994-04-28
Granted: 2002-09-05
Abstract: A rotatable digester drum for convening organic waste material into compost which has internally disposed along its longitudinal axis a series of spaced-apart baffles, each baffle having a variable cross sectional area ranging from 60 to 100% of the cross sectional area of the drum and arranged with respect to one another when in the partially open mode to cause material and air introduced into the drum to traverse a non-linear path through the drum, the drum having a plurality of longitudinally extending internal ribs arranged in spaced array around its circumference.
Patent DE-69432078-D1 (DE)
Inventor: SCHAEFER PETER
IPC: C07D213/89
Filed: 1994-07-11
Granted: 2003-03-06
Abstract: PCT No. PCT/EP94/02264 Sec. 371 Date Jan. 11, 1996 Sec. 102(e) Date Jan. 11, 1996 PCT Filed Jul. 11, 1994 PCT Pub. No. WO95/02590 PCT Pub. Date Jan. 26, 1995A substituted 2-phenylpyridine of the formula I where Ar is and the N-oxides of I and the agriculturally utilizable salts of I where these exist. Use: herbicides; desiccation/defoliation of plants.
Patent DE-69512660-D1 (DE)
Inventor: PLATELL OVE
IPC: F01K3/08
Filed: 1995-06-19
Granted: 1999-11-11
Abstract: PCT No. PCT/SE95/00753 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 19, 1995 PCT Pub. No. WO95/35432 PCT Pub. Date Dec. 28, 1995Disclosed is a steam buffer for use in a steam engine power plant with a closed system and designed to alternately accumulate and emit steam under high pressure and temperature. The steam buffer improves upon conventional steam accumulators which contain water and steam at high pressures and temperature in a large pressurized vessel. The steam buffer functions to store heat in solid material in the walls of a large number of long flow channels with a hydraulic diameter at least as small as 0.5 mm contained in a casing. The flow channels may be formed, for example, by capillary tubes attached to each other or, alternatively, by fine grains of metallic or ceramic material sintered together. The walls of the flow channels perform as the primary heat storing material and are made of a material having a melting point higher than the operating temperature in the steam buffer.
Patent DE-69518706-D1 (DE)
Inventor: MANO TOMIYA
IPC: A61K31/22
Filed: 1995-06-14
Granted: 2000-10-12
Abstract: The present invention provides a novel drug for treating glaucoma.   The present invention relates to a therapeutic agent for glaucoma and an ocular hypotensive agent, which comprise an aminoalkoxybibenzyl represented by the formula (I): <CHEM> wherein R<1> represents a hydrogen atom, a C1-C5 alkoxy group, etc.; R<2> represents a hydrogen atom, a halogen atom, etc.; R<3> represents a hydrogen atom, a hydroxyl group, -O-CO-(CH2)l-COOH (wherein l is an integer of 1 to 3), etc.; and R<4> represents -NR<5>R<6> (wherein R<5> and R<6> independently represent a hydrogen atom or a C1-C8 alkyl group), etc. or a salt thereof as an active ingredient.