Patent SG-11201907820S-A (SG)
Title: Inhibitors of (alpha-v)(beta-6) integrin
Inventor: BREWER MARK
IPC: C07D471/04
Filed: 2018-02-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WI P0 I P C T omit Elmo° (10) International Publication Number WO 2018/160521 A2 (51) International Patent Classification: C07D 401/12 (2006.01) C07D 471/04 (2006.01) (21) International Application Number: PCT/US2018/019838 (22) International Filing Date: 27 February 2018 (27.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,693 28 February 2017 (28.02.2017) US (71) Applicant: LAZULI, INC. [US/US]; 35 Gatehouse Drive A2, Waltham, MA 02451 (US). (72) Inventors: BREWER, Mark; Tramora Bottom Lane, Checkendon, Reading, Oxon R98 ONR (US). BURSAVICH, Matthew, Gregory; 172 Damon Road, Needham, MA 02494 (US). GERASYUTO, Aleksey, Lgo- revich; 20 Skyline Drive, Flemington, NJ 08822 (US). HAHN, Kristopher, Neil; 32 Webster Street, Medford, MA 02155 (US). HARRISON, Bryce, Alden; 7 Old Wood Road, Framingham, MA 01701 (US). KONZE, Kyle, David; 224 E. 70 Street, Apt. 6, New York, NY 10021 (US). LIN, Fu-yang; 44 Saxony Drive, Sudbury, MA 01776 (US). LIPPA, Blaise, Scott; 340 Pope Road, Concord, MA 01742 (US). LUGOVSKOY, Alexey, Alexandrovich; 35 Audrey Road, Belmont, MA 02478 (US). ROGERS, Bruce, Nelsen; 252 Common Street, Belmont, MA 02478 (US). SVENSSON, Mats, Ake; 160 West 24th Street, Apt. 19C, New York, NY 10011 (US). TROAST, Dawn, Marie; 325 Springs Road, Bedford, MA 01730 (US). (74) Agent: GORDON, Dana, M. et al.; Foley Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, O UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) 1-1 O \" (57) : Disclosed are small molecule inhibitors of m436 integrin, and methods of using them to treat a number of diseases and 0 conditions. (54) Title: INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN