Patent SG-11201811640S-A (SG)
Title: Multispecific antigen binding proteins and methods of use thereof
Inventor: CHOU CHUAN-CHU
IPC: C07K16/46
Filed: 2017-07-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/014855 Al 25 January 2018 (25.01.2018) WI P0 I P C T (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C07K 16/46 (2006.01) C07K 16/24 (2006.01) kind of regional protection available): ARIPO (BW, GH, C07K 16/18 (2006.01) A61K 39/395 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, C07K 16/28 (2006.01) A61P 35/00 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, C07K 16/30 (2006.01) A61P 37/00 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, PCT/CN2017/093644 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (22) International Filing Date: KM, ML, MR, NE, SN, TD, TG). 20 July 2017 (20.07.2017) (25) Filing Language: English Published: — with international search report (Art. 21(3)) (26) Publication Language: English — with sequence listing part of description (Rule 5.2(a)) (30) Priority Data: PCT/CN2016/090703 20 July 2016 (20.07.2016) CN (71) Applicant: NANJING LEGEND BIOTECH CO., LTD. [CN/CN]; No.6 Building of Nanjing Life Science Town, No. 568 Longmian Avenue, Jiangning District, Nanjing, Jiangsu 211100 (CN). Inventors: CHOU, Chuan-Chu; 909 Prospect Street, Westfield, New Jersey 07090 (US). ZHANG, Yafeng; 599 = (72) Lize Road, Building 35, Room 302, Moling Street, Jiangn- ing District, Nanjing, Jiangsu 211100 (CN). WU, Shu; 28 Chengxu Road, Huayu Court, Building 3, Room 501, Moling Street, Jiangning District, Nanjing, Jiangsu 211100 (CN). LIU, Zhenyu; 228 Tianyuan East Road, Lai Yin Dong Jun, Yingxia Yuan #15-304, Jiangning District, Nan- jing, Jiangsu 211100 (CN). LI, Zhongdao; 393 Zhushan South Road, Jiangning District, Nanjing, Jiangsu 211100 (CN). ZHANG, Fangliang; No. 28, Yongxi Road, Jiangn- ing District, Nanjing, Jiangsu 211100 (CN). Agent: CHENG & PENG INTELLECTUAL PROPER- (74) TY LAW OFFICE; 821 Yufei Plaza, 42 Dongzhimenwai Avenue, Dongcheng District, Beijing 100027 (CN). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) 1-1 ir) ir) GC 1 1' Il © (54) Title: MULTISPECIFIC ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF --.... ,-1 (57) : Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain 0 comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a \" single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use 0 thereof are further provided.