Patent SG-11201805311X-A (SG)
Title: Method of treating a mammal, including human, against cancer using methionine and asparagine depletion
Inventor: AGUERA KARINE
IPC: A61K38/46
Filed: 2017-01-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 6 July 2017 (06.07.2017) WIPOIPCT (10) International Publication Number WO 2017/114966 A1 (51) International Patent Classification: A61K38/46 (2006.01) A61K35/18 (2015.01) A61K38/51 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/EP2017/050006 2 January 2017 (02.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15307197.2 31 December 2015 (31.12.2015) EP (71) Applicant: ERYTECH PHARMA [FR/FR]; 60 avenue Rockefeller, 69008 Lyon (FR). (72) Inventors: AGUERA, Karine; c/o Erytech Pharma, 60, avenue Rockefeller Batiment Adenine, 69008 Lyon (FR). BERLIER, Willy; c/o Erytech Pharma, 60, avenue Rocke­ feller Batiment Adenine, 69008 Lyon (FR). GAY, Fabien; c/o Erytech Pharma, 60 avenue Rockefeller Batiment Adenine, 69008 Lyon (FR). GODFRIN, Yann; c/o Erytech Pharma, 60, avenue Rockefeller Batiment Aden­ ine, 69008 Lyon (FR). (74) Agents: COLOMBET, Alain et al.; Lavoix, 62, rue de Bonnel, 69448 Lyon Cedex 03 (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: METHOD OF TREATING A MAMMAL, INCLUDING HUMAN, AGAINST CANCER USING METHIONINE AND ASPARAGINE DEPLETION o\ •t 3 ® %fc- i 50 3 40 % Celt viability sf HL-60, AMI. celt line SxpennK'rrta'i ncm-rfitsons Hon* S iCSG L-sspa CO cdis* ICS&!<3l CO '4 CSiiS* 1CS0 1/ 5Spa ® MZ $ -;*• '¥30 -Wei Of- * fCSO t ; *03 ; Figure 1 o CJ (57) : The invention is related to a new method for treating liquid and solid cancers, in a mammal, including human, wherein methioninase is administered before asparaginase. The invention also encompasses the use of a dietary methionine depriva­ tion, possibly combined with methioninase administration, in advance of asparaginase treatment. Methioninase and asparaginase may be used in particular under free form, pegylated form or encapsulated into erythrocytes.