Patent GB-1017862-A (GB)
Title: 1, 3, 5-triazines and preparation thereof
IPC: C07D401/14
Filed: 1964-01-10
Abstract: The invention comprises compounds of the formulae <FORM:1017862/C2/1> (wherein R1 is chlorine, alkylamino, dialkylamino, pyrrolidino, piperidino or morpholino, or, in the compounds containing X, alkoxy; R2 has the same values as R1 with the exception of chlorine, but need not be the same as R1, the total number of carbon atoms in R1 and R2 being from 3 to 11 inclusive; X is -NH- or -N(alkyl)-, the alkyl group containing at most 6 carbon atoms; Alk is alkylene of at most 6 carbon atoms; R3 and R4 are hydrogen or alkyl of at most 6 carbon atoms, or -NR3R4 is pyrrolidino, piperidino or morpholino, or R3 may form a ring together with Alk, or, in the compounds containing X, with NH) and acid-addition salts thereof; the preparation of the compounds containing X by reacting the appropriate 2 - R1 - 4 - R2 - 6 - chloro - triazine (in which R1 and R2 are not alkoxy) with the diamine HX-Alk-NR3R4 or by reacting the appropriate 2,4 - dichloro - 6 -( - X-Alk-NR3R4)-triazine with an alkali metal salt of an alkanol or with an alkylamine, dialkylamine, pyrrolidine, morpholine or piperidine, and, if desired, if R3 and/or R4 are hydrogen, alkylating the nitrogen atom of the side chain; and the preparation of the compounds containing the -O-Alk-NR3R4 side chain by reacting the appropriate 2 - R1 - 4 - R2 - 6 - chloro - triazine with an alkali metal salt of the alcohol HO-Alk-NR3R4. Examples are given and a list of salt-forming acids is provided.  2 - Hexylamino - 4 - diethylamino - 6 - chloro - 1,3,5-triazine is prepared from 2-diethylamino-4,6-dichloro-triazine and hexylamine.ALSO:Triazines of the formula <FORM:1017862/A5-A6/1> (wherein R1 is chlorine, alkoxy, alkylamino, dialkylamino, pyrrolidino, piperidino or morpholino; R2 is alkoxy, alkylamino, dialkylamino, pyrrolidino, piperidino or morpholino; X is NH or N-alkyl of at most 6 carbon atoms; Alk is alkylene of at most 6 carbon atoms; R3 and R4 each is hydrogen or C1-6 alkyl, or NR3R4 is pyrrolidino, piperidino or morpholino; the total number of carbon atoms in R1 and R2 being 3 to 11; and wherein R3 may form a ring together with Alk and may also form a ring with X when NH) and acid-addition salts thereof and triazines of the formula <FORM:1017862/A5-A6/2> (wherein R1 and R2 have the above values excluding alkoxy; Alk is as defined above; R3, R4 and NR3R4 are as defined above; the total number of carbon atoms in R1 and R2 being 3 to 11; and wherein R3 may form a ring together with Alk) and acid-addition salts thereof, are appetite moderating agents and are incorporated in compositions with suitable carriers.  Elixirs, tablets, enduret tablets, pills, powders, capsules, pearls, dragees, solutions, suspensions and emulsions which may contain preserving, stabilizing, wetting or emulsifying agents, salts to change the osmotic pressure, or buffers, are referred to.  They may also contain vitamins and trace elements.  Dragees and pearls containing 2, 4-bis-diethylamino-6-(21-morpholinyl-(411)-ethoxy)-1, 3, 5-triazine and 2, 4-bis-diethylamino-6 -(21-pyrrolidinyl-(111)-ethoxy)-1, 3, 5-triazine respectively and capsules containing 2-butoxy-4-diethylamino-6-(21-diethylamino-ethylamino)-1, 3, 5-triazine are exemplified.