Patent SG-11201408324Q-A (SG)
Title: Pyridinone and pyridazinone derivatives
Inventor: HUBBARD ROBERT DALE
IPC: A61K31/351
Filed: 2012-06-12
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185284 A1 (51) International Patent Classification: C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) A61K 31/351 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 3/10 (2006.01) A61P 3/04 (2006.01) A61P 29/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/CN2012/076748 12 June 2012 (12.06.2012) English English (71) Applicant (for all designated States except US): ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road, Ab­ bott Park, Illinois 60064 (US). (71) Applicant (for LC only): ABBOTT LABORATORIES TRADING (SHANGHAI)COMPANY, LTD. [CN/CN]; 28/F, Ciro's Plaza, 388 West Nanjing Road, Shanghai 200000 (CN). (72) Inventors; and (75) Inventors/Applicants (for US only): HUBBARD, Robert Dale [US/US]; 2796 Hancock Ct, Lindenhurst, Illinois 60046 (US). MCDANIEL, Keith F. [US/US]; 26029 W. Laurel Court, Wauconda, Illinois 60084 (US). PARK, Chang Hoon [US/US]; 2871 N. Southern Hills Dr., Wadsworth, Illinois 60083 (US). PRATT, John K. [US/US]; 8210 61st Avenue, Kenosha, Wisconsin 53142 (US). SOLTWEDEL, Todd [US/US]; 4808 W Strong St, Chicago, Illinois 60630 (US). SUN, Chaohong [US/US]; 390 Churchill Lane, Gurnee, Illinois 60031 (US). WANG, Le [US/US]; 338 East Colonial Drive, Vernon Hills, Illinois 60061 (US). WENDT, Michael D [US/US]; 1445 Maidstone Drive, Vernon Hills, Illinois 60061 (US). (74) Agent: CHINA PATENT AGENT (HK) LTD.; 22/F., Great Eagle Center, 23 Harbour Road, Wanchai district, Hong Kong (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: PYRIDINONE AND PYRIDAZINONE DERIVATIVES (I) 00 CJ 00 T-H i-H (57) Abstract: Compounds of formula (I) wherein A , 1 A , A , A , J, 2 3 4 L, G, and R have any 1 of the values defined in the specification, © and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflam- ^ matory diseases, diabetes, obesity, cancer, and AIDS are disclosed. Pharmaceutical compositions comprising one or more com- Q pounds of formula (I) also are disclosed.