baber/WOPTO huggingface dataset:
Patent DE-274886-T1 (DE)
IPC: B41M5/124
Filed: 1987-12-17
Abstract: Record material comprising a paper sheet having on its front a printable pigment coating and on its back isolated droplets of colour former solution each confined within a pressure rupturable barrier, wherein the pigment coating comprises a binder for the pigment together with a synthetic reactive sizing agent or a coating structure agent or both the sizing agent and the coating structure agent.
Patent ES-2668851-T1 (ES)
Title: Novedoso sistema de compresión para el tratamiento y la prevención de enfermedades venosas
Inventor: LECOMTE SERGE
IPC: A61F13/02
Filed: 2007-03-23
Abstract: Sistema de compresión bicapa caracterizado por que comprende: - una primera capa de compresión que consta de una banda elástica unida en toda su superficie a una capa absorbente y que tiene un diferencial de presión correspondiente a la fórmula: Δ (mm de mercurio) >= 0,7955 CED (Newtons/cm) + 1,8; en la que CED representa el coeficiente de elasticidad dinámica de la primera capa; - una segunda capa de compresión que consta de una banda elástica autoadhesiva que tiene un diferencial de presión correspondiente a la fórmula: Δ (mm de mercurio) >= 0,7955 CED (Newtons/cm) + 1,8; en la que CED representa el coeficiente de elasticidad dinámica de la segunda capa; estando comprendido el diferencial de presión del sistema de compresión entre 10 y 40 mm de mercurio.
Patent ES-2034947-T1 (ES)
Title: Procedimiento y dispositivo para trocear cogollos de verduras.
IPC: A23N15/00
Filed: 1992-01-03
Abstract: LA INVENCION TRATA DE UN METODO Y UN DISPOSITIVO PARA CORTAR LAS CABEZAS DE LAS VERDURAS, FRUTAS O PARTES DE ELLAS, QUE EN SU PARTE INFERIOR MUESTRAN UNA PARTE MEDIA (TRONCHO), QUE A LO LARGO DE UNA SUPERFICIE EN FORMA DE MEDIA ESFERA O DE ARCO OJIVAL SE CORTA POR LA PARTE QUE LE RODEA, ESPECIALMENTE LA COLIFLOR (6), Y EN LA CUAL ESTA FIJO EL DIAMETRO (D) DE LA COLIFLOR (6) Y QUE SE APLICA EL VALOR AVERIGUADO, PARA AJUSTAR Y ACCIONAR EL CUCHILLO (14), DIRIGIDO EN UNA CIRCULAR Y QUE ATRAVIESA EL CORTE, Y CON LA FINALIDAD ESPECIAL DE, ADAPTAR EL PERIMETRO DE LA BANDA CIRCULAR DEL CUCHILLO Y LA PROFUNDIDAD DE INFILTRACION DEL CUCHILLO (14). PARA LA MEJORA DEL METODO, ASI COMO DEL DISPOSITIVO, SE PLANEA QUE, ADEMAS SE TANTEE LA ALTURA DE LA COLIFLOR, CON LA QUE SE TRABAJA Y QUE SE TRANSFORME EL VALOR PARA EL PERIMETRO Y LA ALTURA EN SEÑALES ELECTRICAS Y ASI SE TRABAJA, A PARTIR DE SEÑALES ELECTRICAS, QUE SE APLICAN PARA EL ACCIONAMIENTO ELECTROMECANICO DEL PROCESO DE CORTE DE DICHA FORMA, DE MANERA QUE SE CONSIGUE, EL AJUSTE MENCIONADO DEL PERIMETRO DE LA BANDA CIRCULAR DE CORTE, INDEPENDIENTEMENTE DE LA PROFUNDIDAD DE PENETRACION DE CORTE.
Patent ES-2052474-T1 (ES)
Inventor: SATRAN AMIR
IPC: B23C5/06
Filed: 1993-09-07
Abstract: A substantially square-shaped exchangeable milling insert for mounting in a cylindrical milling cutter tool for millint 90 DEG recesses in a workpiece and having four indexable cutting edges from respective side edges of said base and intersecting said rake surface, each cutting edge comprising first, second and third successive angularly disposed portions being such that during cutting, the first and second portions of a cutting edge cut an upright surface of a substantially 90 DEG  recess in a workpiece with a third portion of an adjacent cutting edge serving as a wiper for a base surface of the recess, at least the first and second portions of each cutting edge being so located that all points thereon lie on a cylindrical envelope generated by a line parallel to a rotary axis of the cutting tool and rotating with respect to the rotary axis at a radius equal to the cutting radius of the cutting tool. <IMAGE>
Patent ES-2064304-T1 (ES)
Inventor: HUGHES MARTIN NEVILLE KINGS CO
IPC: A23L1/304
Filed: 1993-12-16
Abstract: Microbial biomass cells wherein at least one metal cationic species is attached to the surface of said cells in an amount sufficient to render the said cells effective to bind anions thereto, and wherein at least one anionic species is also bound to the surface of said cells. Minerals such as selenium, zinc may be bound to the cells and the biomass used as a food supplement. Alternatively the cells carrying a metal cationic species may be used to remove toxic an ions e.g. selenates, arsenates, chromates from aqueous solutions.
Patent ES-2085843-T1 (ES)
Title: Dispositivo de ajuste para un herraje de desviacion.
Inventor: GOLZ ULRICH
IPC: B60R22/20
Filed: 1995-10-05
Abstract: EL DISPOSITIVO DE AJUSTE PARA UN HERRAJE DE ARTICULACION DE INVERSION DE UN SISTEMA DE CINTURON DE SEGURIDAD EN VEHICULOS CON AL MENOS UN ASIENTO AJUSTABLE EN LA DIRECCION LONGITUDINAL DEL VEHICULO ABARCA UN PRIMER CABLE (28) DE TRACCION GUIADA EN DISPOSICION DE CONTACTO EN EL ASIENTO DEL VEHICULO Y HACIA EL PERIMETRO DE UN PRIMER RODILLO (26) Y UN SEGUNDO CABLE (18) DE TRACCION, QUE SE CONECTA AL HERRAJE DE ARTICULACION DE INVERSION Y SE GUIA HACIA EL PERIMETRO DE UN SEGUNDO RODILLOS (24). LOS RODILLOS (24,26) ESTAN SUJETOS UNO CONTRA OTRO A TRAVES DE UN RESORTE (36) EN ESPIRAL Y ACOPLADOS UNO CON OTRO DE FORMA FIJA DE GIRO HASTA QUE SE SOBREPASA UN MOMENTO DE GIRO DETERMINADO, EVITANDOSE CON ELLO UNA SOBRECARGA DE TODOS LOS COMPONENTES DEL DISPOSITIVO DE AJUSTE.
Patent ES-2112223-T1 (ES)
Inventor: CESHKOVSKY LUDWIG
IPC: G11B7/09
Filed: 1996-03-19
Abstract: The present invention allows the light beam of an optical disc storage device to radially move between different information tracks of an optical disc while the storage device tracking servo loop remains in a continuous closed loop mode of operation. The invention operates to radially move a light beam from one information track to another during a closed loop mode of operation by activating two control signals introduced into the closed tracking servo loop to create a phantom track center that radially moves across the optical disc. Because the tracking servo loop is in a closed loop mode of operation, the tracking servo operates to keep the light beam centered on the point that the tracking servo considers to be the center of an information track; in this case the phantom track center. Therefore, the tracking servo causes the light beam to radially move across the disc in a closed loop mode of operation by keeping the light beam centered on the moving phantom track center. <IMAGE>
Patent CY-1108121-T1 (CY)
Inventor: VILLANI FLAVIO
IPC: C07D335/12
Filed: 2008-06-06
Abstract: The present invention relates to a process for the separation of flupentixol isomers, particularly, a process for the preparation of Z-flupentixol and the decanoate ester and novel synthetic intermediates thereof.
Patent CY-1112673-T1 (CY)
Inventor: NAG BISHWAJIT
IPC: C07D277/34
Filed: 2012-02-09
Abstract: Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.
Patent CY-1113020-T1 (CY)
Inventor: COSTANTINO PAOLO
IPC: C12R1/36
Filed: 2012-08-03
Abstract: The invention provides an immunogenic composition comprising a meningococcal serogroup A conjugate and a meningococcal serogroup C conjugate, and further comprising (i) an aluminium phosphate or an aluminium hydroxide adjuvant and (ii) a buffer.
Patent CY-1113235-T1 (CY)
Inventor: WESSEL KLAUS
IPC: A61P15/12
Filed: 2012-08-13
Abstract: The present invention relates to solid compositions comprising a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide or an direct or indirect NO agonist, with arginine being a preferred compound, in combination with a dithiolane, with ±-lipoic acid as a preferred compound, and its use for improvement of sexual function. The compositions according to the invention comprise the NO donor or its precursor in excess, based on the molar amount of the constituents. The compositions are also suited for the improvement of sexual function. In particular the present invention relates to the use of a dithiolane in combination with a NO donor or a precursor thereof for the preparation of a medication for treatment of sexual dysfunction.
Patent CY-1113466-T1 (CY)
Title: Μεθοδος απορροφησης για ανακτηση μολυβδαινικου ή βολφραμικου απο υδατικα διαλυματα
Inventor: DIETZ THOMAS
IPC: C22B3/42
Filed: 2012-09-04
Abstract: Μέθοδος για ανάκτηση μολυβδαινικού ή βολφραμικού από υδατικό διάλυμα, στην οποία γίνεται δέσμευση μολυβδαινικού ή βολφραμικού από το υδατικό διάλυμα σε τιμή pΗ στο εύρος μεταξύ (2) και (6) πάνω σε μη διαλυτό σε ύδωρ, κατιονιωμένο, ανόργανο υλικό-φορέα, το φορτωμένο υλικό-φορέας διαχωρίζεται και το δεσμευμένο μολυβδαινικό ή βολφραμικό απελευθερώνεται ξανά σε υδατικό διάλυμα σε τιμή pΗ στο εύρος μεταξύ (6) και (14). Το κατιονιωμένο ανόργανο υλικό-φορέας είναι για παράδειγμα κατιονιωμένο φυλλοπυριτικό, κατά προτίμηση μπετονίτης που έχει υποστεί ιονανταλλαγή με άλας τεταρτοταγούς αμμωνίου ή όμοιο υλικό τύπου αργίλου. Η μέθοδος είναι κατάλληλη για την ανάκτηση μολυβδαινικού ή βολφραμικού στο πλαίσιο της καταλυόμενης από μολυβδαινικό ή βολφραμικό απολιγνινίωσης χαρτοπολτού με υπεροξείδιο υδρογόνου. Το ανακτηθέν μολυβδαινικό ή βολφραμικό μπορεί να επιστραφεί στην απολιγνινίωση.
Patent CY-1114347-T1 (CY)
Title: Διαλυματα και μεθοδος οφθαλμολογικης διαποτισης
Inventor: DEMOPULOS GREGORY A
IPC: A61K38/00
Filed: 2013-01-04
Abstract: Παρέχονται διαλύματα για περιεγχειρητική ενδοφθαλμική εφαρμογή μέσω συνεχούς διαπότισης κατά την διάρκεια οφθαλμολογικών διαδικασιών. Αυτά τα διαλύματα συμπεριλαμβάνουν πολλαπλούς παράγοντες που δρουν για να αναστείλουν την φλεγμονή, να αναστείλουν τον πόνο, να επιτελέσουν μυδρίαση (διάταση της κόρης του οφθαλμού), και/ή να μειώσουν την ενδοφθαλμική πίεση, όπου οι πολλαπλοί παράγοντες επιλέγονται να στοχεύσουν πολλαπλούς μοριακούς στόχους για να επιτευχθούν οι πολλαπλές διαφορετικές φυσιολογικές λειτουργίες, και συμπεριλαμβάνονται σε αραιές συγκεντρώσεις σε ένα διάλυμα ουσίας-φορέα ισοσταθμισμένων αλάτων.
Patent CY-1119113-T1 (CY)
Title: Σκευασματα με βαση το υαλουρονικο οξυ
Inventor: LEBRETON PIERRE
IPC: A61L27/52
Filed: 2017-06-28
Abstract: Εδώ αποκαλύπτονται πληρωτικά υλικά μαλακών ιστών, για παράδειγμα, δερματικά και υποδόρια πληρωτικά υλικά, με βάση υαλουρονικά οξέα χαμηλού μοριακού βάρους και φαρμακευτικώς αποδεκτά άλατα αυτών, και μέθοδοι παραγωγής αυτών.
Patent CY-1119529-T1 (CY)
Title: Ζιζανιοκτονα βασει μιας υποκατεστημενης θειεν-3-υλ-σουλφονυλαμινο(θειο)καρβονυλ-τριαζολιν(θει)ονης και ενος αναστολεα 4-υδροξυφαινυλο πυρουβικης διοξυγενασης (hppd)
Inventor: DOLLINGER MARKUS
IPC: A01P13/00
Filed: 2017-12-14
Abstract: Η εφεύρεση αναφέρεται σε ζιζανιοκτόνα μέσα που χαρακτηρίζονται από έναν αποτελεσματικής περιεκτικότητας συνδυασμό δραστικών συστατικών αποτελούμενο από
Patent CY-1122585-T1 (CY)
Title: Συνδυασμοι που περιλαμβανουν παραγωγα 5-φαινοξυ-3η-πυριμιδιν-4-ονης και η χρηση αυτων για την προφυλαξη ή αγωγη λοιμωξης απο ηiv
Inventor: ARRINGTON KENNETH L
IPC: C07D239/56
Filed: 2020-02-04
Abstract: Ενώσεις του Τύπου (Ι) και αναστολείς ανάστροφης μεταγραφάσης ΗΙV, όπου τα R1, R2, RΕ, L, Μ και Ζ ορίζονται στο παρόν. Οι ενώσεις του Τύπου (Ι) και τα φαρμακευτικώς αποδεκτά άλατα αυτών είναι χρήσιμα στην αναστολή ανάστροφης μεταγραφάσης ΗΙV, στην προφύλαξη και θεραπευτική αγωγή λοίμωξης από ΗIV και στην προφύλαξη, καθυστέρηση στην εμφάνιση ή πρόοδο, και θεραπευτική αγωγή ΑIDS. Οι ενώσεις και τα άλατα αυτών μπορούν να χρησιμοποιηθούν ως συστατικά σε φαρμακευτικές συνθέσεις, προαιρετικώς σε συνδυασμό με άλλα αντιϊικά, ανοσορρυθμιστές, αντιβιοτικά ή εμβόλια.
Patent CY-1122720-T1 (CY)
Title: Υποδοχεις τ κυτταρων που αναγνωριζουν περιορισμενη μαgε-α3 μηc ταξης ii
Inventor: ROBBINS PAUL F
IPC: C07K14/73
Filed: 2020-03-03
Abstract: Η εφεύρεση παρέχει έναν απομονωμένο υποδοχέα σε καθαρισμένα Τ-κύτταρα (ΤCR), ο οποίος έχει αντιγονική εξειδίκευση για περιορισμένα ΜΑGΕ-Α3 ΜΗC Τάξης II. Η εφεύρεση περαιτέρω παρέχει σχετικά πολυπεπτίδια και πρωτεΐνες, καθώς και σχετικά νουκλεϊκά οξέα, ανασυνδυασμένους φορείς έκφρασης, κύτταρα ξενιστές και πληθυσμούς κυττάρων. Περαιτέρω παρεχόμενα από την εφεύρεση είναι αντισώματα ή τμήμα αντιγόνου σύνδεσης αυτών και φαρμακευτικές συνθέσεις, οι οποίες σχετίζονται με τους ΤCR της εφεύρεσης. Μέθοδοι ανίχνευσης της παρουσίας καρκίνου σε έναν ξενιστή και μέθοδοι θεραπείας ή πρόληψης καρκίνου σε ένα θηλαστικό παρέχονται περαιτέρω από την εφεύρεση.
Patent CY-1126143-T1 (CY)
Title: Συνθεση και ενδιαμεσα του (r)-1-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλο)-ν-(1-(2,3-διυδροξυπροπυλο)-6-φθορο-2-(1-υδροξυ-2-μεθυλοπροπαν-2-υλο)-1η-ινδολ-5-υλο)-κυκλοπροπανοκαρβοξαμιδιου
Inventor: KESHAVARZ-SHOKRI ALI
IPC: C07D405/12
Filed: 2023-08-03
Abstract: Η παρούσα εφεύρεση σχετίζεται με τη σύνθεση και ενδιάμεσα για την παρασκευή (R)-l-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλο)-Ν-(1-(2,3-διυδροξυπροπυλο)-6-φθορο-2-(1-υδροξυ-2-μεθυλοπροπαν-2-υλο)-1Η-ινδολ-5-υλο)-κυκλοπροπανοκαρβοξαμιδίου (Ένωση 1).
Patent GR-880300116-T1 (GR)
Title: Apparatus such as a heat exchanger, particularly for cooling process gas or for heating steam
Inventor: DIPL-ING KLEIN BERND
IPC: F22B1/18
Filed: 1988-12-16
Abstract: 1. A beat exchanger, in particular for cooling process gas or for superheating steam, having a pressure vessel (2) as a heat exchanger vessel with a bundle (13) of heat exchanger tubes (25) secured in a tube base and an antechamber (8) associated with the tube base, the tube base and/or the antechamber being connected to the pressure vessel at certain points via flanges, characterised in that the tube base (19) consists of a flanged ring (7) of a low-alloy material with a concentric inner recess (11) and is provided with an insulating layer (16a) on the side facing the pressure vessel (2), and in that the inner recess (11) of the flange ring (7) is equipped with a substantially crucible-shaped insert (12) projecting into the pressure vessel (2) and made of a high-alloy material.
Patent HR-P20100150-T1 (HR)
Inventor: DUBOIS LAURENT
IPC: A61K31/437
Filed: 2010-03-16
Abstract: Spoj formule (I) naznačen time šton je 0, 1, 2 ili 3; pirolopiridinska jezgra je pirolo[3,2-b]piridinska skupina, pirolo[3,2-c]piridinska skupina, pirolo[2,3-c] piridinska skupina ili pirolo[2,3-b]piridinska skupina; pirolopiridinska jezgra je izborno supstituirana na ugljiku na položaju 4, 5, 6 i/ili 7 s jednim ili više supstituenata X, koji mogu biti istovjetni ili različiti i bira ih se između atoma halogena i C1-C6-alkilne, C3-C7-cikloalkilne, C3-C7-cikloalkil-C1-C3-alkilenske, C1-C6-fluoralkilne, C1-C6-alkoksilne, C1-C6-fluoralkoksilne, cijano, C(O)NR1R2, nitro, NR1R2, C1-C6-tioalkilne, -S(O)-C1-C6-alkilne, -S(O)2-C1-C6-alkilne, SO2NR1R2, NR3COR4, NR3SO2R5 ili arilne skupine, gdje je aril izborno supstituiran s jednim ili više supstituenata, koje se bira između halogena i C1-C6-alkilne, C3-C7-cikloalkilne, C3-C7-cikloalkil-C1-C3-alkilenske, C1-C6-fluoralkilne, C1-C6-alkoksilne, C1-C6-fluoralkoksilne, nitro ili cijano skupine; Z1, Z2, Z3, Z4 i Z5, međusobno neovisno, predstavljaju atom vodika ili halogena ili C1-C6-alkilnu, C3-C7-cikloalkilnu, C3-C7-cikloalkil-C1-C3-alkilensku, C1-C6-fluoralkilnu, C1-C6-alkoksilnu, C1-C6-fluoralkoksilnu, cijano, C(O)NR1R2, nitro, NR1R2, C1-C6-tioalkilnu, -S(O)-C1-C6-alkilnu, -S(O)2-C1-C6-alkilnu, SO2NR1R2, NR3COR4, NR3SO2R5, aril-C1-C6-alkilensku ili arilnu skupina, gdje su aril i aril-C1-C6-alkilen izborno supstituirani s jednim ili više supstituenata, koje se bira između halogena i C1-C6-alkilne, C3-C7-cikloalkilne, C3-C7-cikloalkil-C1-C3-alkilenske, C1-C6-fluoralkilne, C1-C6-alkoksilne, C1-C6-fluoralkoksilne, nitro ili cijano skupine; R1 i R2, međusobno neovisno, predstavljaju atom vodika ili C1-C6-alkilnu, C3-C7-cikloalkilnu, C3-C7-cikloalkil-C1-C3-alkilensku, aril-C1-C6-alkilensku ili arilnu skupinu; ili R1 i R2 tvore, zajedno s atomom dušika koji ih nosi, azetidinsku, pirolidinsku, piperidinsku, azepinsku, morfolinsku, tiomorfolinsku, piperazinsku, homopiperazinsku skupinu, gdje je ta skupina izborno supstituirana s C1-C6-alkilnom, C3-C7-cikloalkilnom, C3-C7-cikloalkil-C1-C3-alkilenskom, aril-C1-C6-alkilenskom ili arilnom skupinom; R3 i R4, međusobno neovisno, predstavljaju atom vodika ili C1-C6-alkilnu, aril-C1-C6-alkilensku ili arilna skupinu; R5 predstavlja C1-C6-alkilnu ili arilnu skupinu; W predstavlja kondenziranu bicikličku skupinu formule: vezanu na atom dušika preko položaja 1, 2, 3 ili 4; A predstavlja 5- do 7- člani heterocikl, koji sadrži jedan do tri heteroatoma, koje se bira između O, S i N; jedan ili više atoma ugljika u A su izborno supstituirani s jednom ili više skupina, koje se bira između atoma vodika i C1-C6-alkilne, C3-C7-cikloalkilne, C3-C7-cikloalkil-C1-C3-alkilenske, C1-C6-fluoralkilne, arilne, aril-C1-C6-alkilenske, okso ili tio skupine; jedan ili više atoma dušika u A su izborno supstituirani s R6 kada je dušik vezan na atom ugljika supstituiran s okso skupinom, ili s R7 u drugim slučajevima; R6 predstavlja atom vodika ili C1-C6-alkilnu, C3-C7-cikloalkilnu, C3-C7-cikloalkil-C1
Patent HR-P20100679-T1 (HR)
Inventor: LERESTIF JEAN-MICHEL
IPC: C07D223/16
Filed: 2010-12-07
Abstract: Postupak za opticku resoluciju spoja (3,4-dimetoksi-biciklo[4.2.0]okta-1,3,5-trien-7-il)nitrila formule (I), naznacen time, da se racemicka ili enantiomerski obogacena smjesa spoja (3,4-dimetoksi-biciklo[4.2.0]okta-1,3,5-trien-7-il)nitrila kiralnom kromatografijom razdvaja na svoja dva enantiomera, (S)-(3,4-dimetoksi-biciklo [4.2.0]okta-1,3,5-trien-7-il)nitril formule (Ia) i (R)-(3,4-dimetoksi-biciklo[4.2.0]okta-1,3,5-trien-7-il)nitril formule (Ib). Patent sadrzi jos 20 patentnih zahtjeva.
Patent SI-1200122-T1 (SI)
Title: Multi-component vaccine to protect against disease caused by haemophilus influenzae and moraxella catarrhalis
Inventor: LOOSMORE SHEENA M
IPC: A61K39/116
Filed: 2000-07-11
Abstract: A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis. Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae, and at least one antigen from Moraxella catarrhalis. Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.
Patent SI-1483290-T1 (SI)
Title: Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments
Inventor: KAWABE TAKUMI
IPC: A61K38/00
Filed: 2003-01-17
Abstract: This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting G2 cell cycle checkpoint. Thus, invention compounds can be used to inhibit cell growth alone or be used in combination with a nucleic acid damaging treatment to inhibit cell growth.
Patent SI-1836210-T1 (SI)
Title: PROCESS FOR THE PREPARATION OF ?á1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDEN?åBISPHOSPHONIC ACID AND HEMI-PENTAHYDRATE MONOSODIUM SALT THEREOF
Inventor: DEMBKOWSKI LESZEK
IPC: C07F9/00
Filed: 2005-12-28
Abstract: The invention relates to a novel process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid and hemipentahydrate monosodium salt thereof comprising (a) reacting an aqueous solution of 3-pyridyl acetic acid hydrochloride with phosphorus trichloride; (b) removing unreacted phosphorus trichloride; (c) adding water and hydrolyzing; (d) isolating crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid; (e) suspending said crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid in water; (f) adding sodium hydroxide, filtering off, and washing; and (g) drying obtained hemipentahydrate monosodium salt of 1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid.
Patent SI-1773683-T1 (SI)
Title: Package comprising a plastic container closed with a peelable inner seal heat-sealed to said container
Inventor: RICK JEAN-LUC
IPC: B65D77/00
Filed: 2005-07-05
Abstract: The invention concerns a package (1) comprising a container (10) provided with a surface (12) delimiting an opening (14), and an inner seal (16) sealed on the surface (129 and removable by peeling. The invention is characterized in that: a) the inner seal (16) comprises a support sheet (20) and an extruded (22') or co-extruded (22) plastic layer, forming or comprising a sealing layer (38', 38); b) said extruded (22') or co-extruded (22) layer is made of a material selected to adhere, through its outer surface, to said support sheet (20), and through its inner surface, to said surface (12) when sealed; c) said support sheet (20) is coated on its outer surface with a metal-plated film 21); d) and in that said extruded (22') or co-extruded (22) layer has a thickness Ec selected such that said peeling of the inner seal (16) brings about a coherent rupture of the extruded (22') or co-extruded (22) layer. The invention provides the advantage that said seals enable a broader selection of sealing techniques.
Patent SI-1845120-T1 (SI)
Title: Aqueous polyurethane dispersions with improved storage stability
Inventor: GERTZMANN ROLF DR
IPC: C09D175/00
Filed: 2007-03-29
Abstract: A hydrazine-free aqueous polyurethane dispersion comprises (a) polyisocyanate(s), (b) polyol(s) having average molar weights (M n) of 500-6000 g/mol; (c) polyol(s) having M n of 62-500 g/mol; (d) compound(s) containing an ionic group or a group capable of forming an ionic group; (e) polyamine(s) having M n below 500 g/mol; (f) optionally monoalcohol(s) having M n of 32-145 g/mol; and (g) optionally monoamine(s) having M n of less than 147 g/mol. At least one of (f) and (g) is used. The fraction of (f) and/or (g) is >=0.4-1.26 wt.%; and the fraction of (c) is greater than 5.5-22 wt.%. An independent claim is included for a process of preparing the hydrazine-free aqueous polyurethane dispersion, comprising preparing isocyanate (NCO) prepolymer solution in a concentration of 66-98% in a solvent having a boiling point below 100[deg]C, under atmospheric pressure by reacting components (a), (b), (c), and (d); dispersing the NCO prepolymer in water, with at least partial neutralization of the ionic groups taking place before, during, or after dispersion; chain extending the NCO prepolymer with component (e); and distilling the resulting dispersion to remove the solvent. Provided that, component (f) is used in the first step, or component (g) in the third step.
Patent SI-2831113-T1 (SI)
Title: Antibodies to bradykinin b1 receptor ligands
Inventor: KOMINOS Dorothea
IPC: C07K16/00
Filed: 2013-03-15
Abstract: The invention provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-Kallidin or des-Arg10-Kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to modulate Kallidin or des-Arg10-Kallidin activity or detect Kallidin or des-Arg10-Kallidin or, either in vitro or in vivo, are also provided by the invention. The invention further provides methods of making antibodies that specifically bind to des-Arg 9 -Bradykinin and des-Arg 10 -Kallidin-like peptide.