baber/WOPTO huggingface dataset:
Patent CA-2303449-A1 (CA)
Title: The preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
Inventor: LEVIN JEREMY IAN
IPC: C07F9/547
Filed: 1998-04-14
Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme) of formula (B) wherein (B) is (1), (2), or (3); P and Q are (4) or (5), provided that when P is (4), Q is (5), and vice versa; T, U, W, and X are each, independently, carbon or nitrogen, provided that when T or U is carbon, either may be optionally substituted with R1; Y is carbon, nitrogen, oxygen or sulfur, provided that at least one of T, U, W, X, and Y is not carbon, and further provided that no more than 2 of T, U, W, and X are nitrogen; (6) is a phenyl ring or is a heteroaryl ring of ring 5-6 atoms which may contain 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, in addition to any heteroatoms defined by W or X; wherein the phenyl or heteroaryl ring may be optionally mono-, di-, or tri- substituted with R1; Z is a phenyl, naphthyl, heteroaryl, or heteroaryl fused to phenyl, wherein the heteroaryl moiety contains of 5-6 ring atoms and 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur; wherein the phenyl, naphthyl, heteroaryl, or phenyl fused heteroaryl moieties may be optionally mono-, di-, or tri-substituted with R1; R1 is hydrogen, halogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cyclocalkyl of 3-6 carbon atoms, -(CH2)nZ, -OR2, -CN, -COR2, perfluoroalkyl of 1-4 carbon atoms, -CONR2R3, -S(O)xR2-OPO(OR2)OR3, -PO(OR2)R3, -OC(O)NR2R3, -COOR2, -CONR2R3, -SO3H, -NR2R3, -NR2COR3, -NR2COOR3, -SO2NR2R3, -NR2CONR2R3, -NR2C(=NR3)NR2R3, -SO2NHCOR4, -CONHSO2R4, -tetrazol-5-yl, -SO2NHCN, -SO2NHCONR2R3, or Z; V is a saturated or partially unsaturated heterocycloalkyl ring of 5-7 ring atoms having 1-3 heteroatoms selected from N, O, or S, which may be optionally mono-, or di-substituted with R2; R2 and R3 are each, independently, hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms;  perfluoroalkyl of 1-4 carbon atoms, Z or V; R4 is alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R5 is hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, Z, or V; n = 1-6; x = 0-2 or a pharmaceutically acceptable salt thereof.
Patent CA-2306507-A1 (CA)
Title: Information gathering system
Inventor: MANNINGS ROBIN THOMAS
IPC: H04M3/36
Filed: 1998-11-03
Abstract: An audience participation system is disclosed, in which the users are invited to initiate a voting process by dialling a predetermined number using one of the conventional short code memory keys on a DECT cordless telephone (1), or specialised equipment incorporating DECT technology, are connected to a Computer/Telephony Interface (CTI) Unit (4) via a wireless Private Branch Exchange (WPBX) (2). The Computer/Telephony Interface Unit can use calling line identity to identify any attempted callers who are not eligible to vote, e.g. calling from remote lines. Some remote lines may be authorised to allow votes to be contributed from authorised parties elsewhere than in the local auditorium. To vote, the users transmit DTMF tones using the keys of their telephone handsets, or speak into their handsets if voice prompts are to be used. A separate channel is provided between the Computer/Telephony Interface Unit (4) and each cordless telephone or remote user. The Computer/Telephony Interface Unit (4) can therefore identify each individual vote, and ensure that only one vote is received from each telephone. The DTMF tones or other are raw voting data which is transmitted to the computer (5) for analysing the raw voting data, for display of voting statistics to the audience on a display browser (6). Since the identity of each handset is known to the Computer/Telephony Interface Unit (4), demographic data previously stored relating to the individual users of the handsets, or to earlier voting results, may be correlated to provide further information for processing by the computer (5). Variations of the system are disclosed for use in examinations, and for use in exhibitions etc., the information to be transmitted being selected according to the currently serving radio base station, and pre-programmed information selected by the user.
Patent CA-2312126-A1 (CA)
Inventor: VILKOV BORIS NIKOLAYEVICH
IPC: G11C29/00
Filed: 1998-11-30
Abstract: A transformation means for transforming memory cell addresses between different memory device topologies providing the use of minimum memory space and time required for storage and computing defect data and also the flexibility of approach which allows the use of a wide spectrum of mapping classes and simplification of the transforming procedure.
Patent CA-2312354-A1 (CA)
Title: Automatic battery detection system and method for detecting a rechargeable battery with low remaining charge
Inventor: CARKNER STEVEN
IPC: H02J7/00
Filed: 2000-06-21
Abstract: A system includes a charging cradle that receives an electronic hand-held device powered by a battery. Inside the charging cradle a controller performs a method of internal-device battery cell detection, i.e., distinguishing between NiMH/NiCd and other types of cells in the battery, before recharging the battery. A method determines the cell chemistry without any modifications to the battery and/or without any user input by performing tests on the battery. The tests include a Battery Voltage Test, an Internal Resistance Test, and a Timed Voltage Test. The testing is performed through a combination of hardware and software in the charging cradle. By performing the tests in a preferred order, detected alkaline, lithium, rechargeable alkaline, and carbon-zinc cells, damaged NiMH and NiCd cells, and close to fully charged NiMH and NiCd cells cause termination of a recharging operation before damage to the device or battery is sustained without requiring input from a user.
Patent CA-2313733-A1 (CA)
Inventor: MILLER ROY W
IPC: B61D7/00
Filed: 2000-07-07
Abstract: A dual hopper rail car is converted from a three-hopper rail car. The converted rail car includes a pair of hoppers with each hopper including a discharge opening for discharging contents of the hopper. A center sill, pair of top chords, a pair of side sills and a pair of side sheets extend along the length of the converted rail car and each includes a welded splice connection. The welded splice connection of each side sheet is adjacent and between a pair of side stakes with a tie plate extending between the pair of side stakes. The method of converting the three-hopper rail car to the two-hopper rail car includes: severing the three-hopper rail car into a first end section, a second end section and a center section that includes the center hopper and a portion of an adjacent hopper; removing the center section; and attaching the first end section to the second end section.
Patent CA-2314929-A1 (CA)
Title: Regulator with artificial load to maintain regulated delivery
Inventor: URBANSKI PAUL J
IPC: A61N1/30
Filed: 1998-12-09
Abstract: An electrotransport device with a drug delivery regulating apparatus delivers a proper drug dosage rate over time by adapting to variable skin resistance values. The electrotransport device adapts to a decline in skin resistance over a time that the electrotransport device is used, and to different skin resistances at different skin surface locations. One drug delivery regulating apparatus includes a voltage booster, a serially connectable artificial impedance, and a feedback sensor, which are all connected to a controller. This apparatus outputs a load voltage across two electrodes. The controller monitors the output of the feedback sensor to determine the skin resistance, or a load current, or the load voltage. Based on the monitored value, the load voltage across the electrodes is controlled, so that a targeted drug dose rate is maintained even as the initial skin resistance drops over the period that the electrotransport device is used. The artificial impedance is selectively controlled to prevent overdose where the skin resistance falls below a predetermined resistance, such that a load voltage greater than a supply voltage could result in an overdose.
Patent CA-2314981-A1 (CA)
Title: Broadband cellular network device
Inventor: RUUTU JUSSI
IPC: H04L12/931
Filed: 1997-12-30
Abstract: A broadband cellular network device comprises a cellular controller means (2) adapted to control the distribution of cellular traffic consisting of asynchronous transfer mode cells in trunking mobile communication networks based on ATM technology, and an asynchronous transfer mode switching means (3) controlled by said cellular controller means and adapted to multicast said cellular traffic to downlink base transceiver stations (4) using multicast properties of the asynchronous transfer mode switching means (3).
Patent CA-2315144-A1 (CA)
Title: Novel farnesyl transferase inhibitors, preparation, pharmaceutical compositions containing them and use for preparing medicines
Inventor: DEREU NORBERT
IPC: A61P43/00
Filed: 1998-12-21
Abstract: The invention concerns novel products of general formula (I), their preparation, the pharmaceutical compositions containing them and their use for preparing medicines. (I) In the general formula (I): Het represents a monocyclic or polycyclic system, for which at least one of the cycles contain 1 to 4 heteroatoms; Ar represents an optionally substituted phenyl radical, a phenyl radical substituted for a heterocycle, a polycyclic or heterocyclic aromatic radical; R represents a -COOH, -COOR¿4?, -CON(R¿5?)(R¿6?) radical in which R¿4? = alkyl, R¿5? = H, alkyl, R¿6? = alkyl, hydrogen, hydroxy, amino optionally substituted, alkoxy; R¿1?, R¿2? = hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl; R¿3? = hydrogen, alkyl, alkylthio; X = methylene, alken-1,1-diyl, cycloalkan-1,1-diyl; in racemic form or the optical isomers or mixtures of their optical isomers, and the salts of the product of general formula (I). The products of general formula (I) are farnesyl transferase inhibitors.
Patent CA-2315624-A1 (CA)
Inventor: ASGHARI MEHDI
IPC: H04B10/40
Filed: 1998-12-18
Abstract: The optical device comprises a diffraction grating (16) for dividing a multiwavelength signal received on an input waveguide (17) into a plurality of signals each of a single wavelength or narrow wavelength band. A first set of waveguides (18) receives signals from a main (mth) diffraction order from the grating (16) to provide an output from the device. A second set of waveguides (19) receives signals from a lower or higher (m + p)th diffraction order from the grating and transmits these signals to light detectors (20). Properties of the output signals on the first set of waveguides (18) can thus be monitored from the properties of the signals received by the light detectors (20) as the properties of the lower or higher (m + p)th diffraction order are closely related to those of the main (mth) diffraction order.
Patent CA-2317118-A1 (CA)
Inventor: TABATA KAZUHIKO
IPC: C12R1/15
Filed: 2000-08-30
Abstract: The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid.  The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic acid aldolase activity or N-acetylneuraminic acid synthetase activity, or a treated matter of the culture, (ii) a culture of a microorganism capable of producing pyruvic acid or a treated matter of the culture, or a culture of a microorganism capable of producing phosphoenolpyruvic acid or a treated matter of the culture, (iii) N-acetylmannosamine, and (iv) an energy source which is necessary for the formation of pyruvic acid or phosphoenolpyruvic acid to be present in an aqueous medium to form and accumulate N-acetylneuraminic acid in the aqueous medium; and recovering N-acetylneuraminic acid from the aqueous medium.
Patent CA-2317959-A1 (CA)
Title: Method for determination of the gross nitrogen-mineralization rate of a soil sample
Inventor: SORENSEN JAN
IPC: C12Q1/34
Filed: 1998-12-10
Abstract: The invention facilitates a determination of the rate at which soil organic nitrogen is converted to inorganic nitrogen or mineral nitrogen. This conversion is known as N-mineralization. The total release of plant available nitrogen in a soil, i.e. the gross N-mineralization rate quantifies the conversion in the soil of organic nitrogen to inorganic nitrogen. The present invention provides a quick and reliable method for measuring the gross N-mineralization rate of a soil sample. The method exploits that a microbial enzyme activity of a functional ornithine acid cycle present in said sample is correlatable with the rate of gross N-mineralization of that same sample. The method of the invention can be used e.g. in a determination of the amount of a nitrogen-containing fertiliser to be applied to a soil such as e.g. a field of agricultural crops.
Patent CA-2318185-A1 (CA)
Inventor: ZAHEDI PARVIZ
IPC: C21B13/14
Filed: 1998-12-22
Abstract: According to the inventive method for producing hot metal, feed materials made up of iron ore, preferably in lump and/or pellet form, and optionally, flux materials, preferably lime and/or dolomite are reduced to sponge iron in a reduction area. The resulting sponge iron is then melted down into hot metal in a melt-down gasification area with solid carbon supports and oxygencontaining gases being added and a reduction gas and slag being formed. Said reduction gas is at least partially introduced into the reduction area, reacted there and drawn off as top gas. The invention also relates to an installation for carrying out this method.
Patent CA-2319167-A1 (CA)
Inventor: BERNARDS RENE
IPC: C12N15/16
Filed: 1999-02-12
Abstract: L'invention concerne la mise en évidence d'une interaction de la cycline D1 et des coactivateurs de la famille SRC-1. L'interaction directe de la cycline D1 améliore la transcription dont la médiation est assurée par les récepteurs oestrogéniques et offre une nouvelle cible pour le développement d'analyses relatives à des substances qui modulent le cycle cellulaire. L'invention concerne en outre des procédés d'analyse permettant de prévenir la croissance tumorale, des analyses relatives à la détermination de composés utiles dans la prévention des tumeurs, et un certain nombre de composés ainsi déterminés.
Patent CA-2320290-A1 (CA)
Title: Multibinding inhibitors of cyclooxygenase-2
Inventor: GRIFFIN JOHN H
IPC: C07D405/04
Filed: 1999-06-07
Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.
Patent CA-2321080-A1 (CA)
Title: Saddle for bicycles
Inventor: BAVARESCO ROBERTO JOSE
IPC: B62J1/00
Filed: 1999-02-18
Abstract: The invention realizes a saddle (1) for bicycles including two separate seats (2, 3) supported by a supporting unit (4) fixed to the bicycle frame. Each one of said seats (2, 3) includes at least a first part (2', 3'), fixed with respect to said supporting unit (4) and at least a second pan (2", 3"), movable with respect to said first part (2', 3'). Said second part (2", 3") is revolvingly connected to a gudgeon (10, 11) defining an axis (10a, 11a) substantially horizontal placed substantially orthogonally to the advancement direction (6) of the bicycle.
Patent CA-2321233-A1 (CA)
Title: Block-wise adaptive statistical data compressor
Inventor: HIND HUGH R
IPC: H03M7/46
Filed: 1999-02-26
Abstract: A block-wise adaptive statistical data compressor is disclosed that operates by replacing characters in a data block with super-character codewords comprising a variable length prefix and a fixed length index.      The codewords are determined by treating a plurality of groups of characters as super-character groups and then adapting the codewords, for each data block, based upon the actual frequency of occurrence of the characters in each group. The super-character prefix value identifies the group to which a particular character belongs, and the index value identifies the individual character of the group. By grouping and indexing the characters into these super-character groups, the present invention models a particular data block using a fraction of the information generally required by a fixed statistical compressor. Also disclosed are multi-stage lossless block data compressors that include the block-wise adaptive statistical compressor and also include a clustering stage and a reordering stage. The clustering stage clusters like characters into similar locations within the data block, and the reordering stage reorders the data to generate an expected skew in the frequency distribution of characters in the data block so that the block can be more efficiently compressed by the block-wise adaptive statistical compressor.
Patent CA-2323113-A1 (CA)
Title: Adaptive telephone handset interface
Inventor: STELMAN BRUCE W
IPC: H04M3/42
Filed: 1999-03-05
Abstract: An adaptive handset interface for interfacing a two-wire analog telephone instrument to a telephone set having a base unit connected to a handset via a four-wire handset cable. The interface is suitable for use with a variety of telephone sets produced by different manufacturers despite differences in the signalling between the telephone base and the handset. This is because, upon initiation of a learning technique, the interface automatically adapts to variations in signalling between the telephone base and handset among the different telephone manufacturers. To use the interface, the handset is unplugged from the handset jack of the telephone base and plugged into a handset jack of the interface. In addition, a four-wire cable is plugged into a telephone base jack of the interface and into the handset jack of telephone base. The interface includes a modular jack for coupling the interface device to the two-wire telephone instrument. The interface device limits a level of a signal received from the two-wire telephone instrument. In addition, the interface device incorporates three different techniques for learning the signalling characteristics of the telephone set: a self-contained technique which is executed under control of a control circuit contained within the interface; a technique which requires the user to dial a telephone number to couple the interface to an automated host system which then controls the learning process; and a technique which requires the user to dial a telephone number and, then, a technician controls the learning process. The latter two of the three techniques are used only if the self-contained technique is not completely successful.
Patent CA-2325006-A1 (CA)
Inventor: ODELL JOHN ANTHONY
IPC: B01L3/00
Filed: 1998-11-30
Abstract: Cette invention, qui a trait à un appareillage, à un instrument et à un dispositif permettant de mener une analyse, concerne plus particulièrement un dispositif convenant à un dosage d'analysat, par exemple des protéines glycosylées présentes dans des prélèvements biologiques tels que du sang. Elle a trait, notamment, à un appareillage, utilisable pour une analyse au cours de laquelle un prélèvement est présenté à un instrument, comportant un premier et un second orifice d'admission ainsi qu'un orifice d'amenée susceptible d'être déplacé relativement aux deux orifices d'admission et d'être mis en communication fluidique avec chacun de ces orifices, selon que nécessaire. Cet orifice d'amenée est pourvu d'un filtre ou d'un dispositif retenant un liant. Cette invention concerne également un instrument, permettant de lire un prélèvement mis dans l'appareil, pourvu d'un microprocesseur fonctionnant à l'aide d'un clavier numérique, d'un ou de plusieurs dispositifs d'émission lumineuse ainsi que d'un ou de plusieurs détecteurs de lumière, d'un afficheur, d'un pilote, d'un convertisseur analogique/numérique et d'un moyen de connexion à une source d'énergie.
Patent CA-2326410-A1 (CA)
Title: Pulling piston engine
Inventor: PATTAKOS EMMANOUEL
IPC: F01L1/00
Filed: 1997-07-22
Abstract: A reciprocating piston engine of a crankshaft of a stroke S and connecting rods of a length L can afford an increase in the time available for the combustion of the fuel substantially equal to (1+S/2L) times the respective time available in the conventional engine, provided that the pistons are equipped with piston rods and the combustion takes place exclusively only under the piston crown underside. To form a closed space under the piston crown the engine has cylinder bottoms instead of cylinder heads and in order to achieve as compact a combustion chamber as in the contemporary conventional engines, the engine has under-bottom poppet valves to enjoy substantially the same advantages that the over-head valves afford to the conventional engines, because the piston rod cross section is only of an area A=P/f, where P is the force from the gas and f is the fatigue strength in substantial simple tension of the material of the piston rod and since no axial force is acting on cylinders they are considerably thin and light. An air flow directly towards the bore wall cools the oil film from within.
Patent CA-2328237-A1 (CA)
Inventor: EGAN THOMAS D
IPC: A61F2/08
Filed: 1999-04-13
Abstract: This invention is an expandable soft tissue fixation assembly (10) for use in anchoring soft tissue to bone. The assembly includes a tab (16) connected to an anchor (18), a sleeve (20) adapted to surround the anchor (18), and a flange (19) adapted to hold a soft tissue segment next to a bone. The sleeve (20) is inserted into a blind hole (12) in a bone, and a section of soft tissue is placed over the hole (12) next to the bone. Energy is applied to the flange (19) while a predetermined axial tension is applied to the tab (16) to compress a flared portion of the anchor against the sleeve (20). An upper tube portion of the anchor and the flange (19) are bonded together. The applied axial force on the tab separates it from the anchor, leaving the assembly anchored in the bone, the soft tissue section anchored in place between the flange (19), and the bone.
Patent CA-2329720-A1 (CA)
Title: Polycarbometallane
Inventor: ABBEY KIRK J
IPC: C08G61/12
Filed: 1999-04-23
Abstract: La présente invention concerne un polymère comportant, d'une part une unité répétitive constituant une ossature, et d'autre part au moins deux atomes de métal liés l'un à l'autre et un unique groupe éthyléniquement insaturé. L'unité ossature présente de préférence la structure suivante: -C(R?3¿)=C(R?3¿)-[C(R?3¿)(R?4¿)]¿n?-[M(R?1¿)(R?2¿)]¿a?-[C(R?3¿)(R?4¿)]¿p?-. Dans cette structure, n vaut de 0 à 4; a vaut au moins 2; p vaut de 0 à 4. R?1¿ et R?2¿ appartiennent indépendamment chacun au groupe des hydrogène, halogène, alkyle inférieur portant jusqu'à 4 atomes de carbone, alcényle portant jusqu'à 4 atomes de carbone ou un aromatique à un seul cycle. R?3¿ et R?4¿ appartiennent indépendamment chacun au groupe des hydrogène et alkyle inférieur en C¿1?-C¿4?. Enfin, M est un atome de métal appartenant au groupe des Sn, Ge, Pb, Hg, Ni, Dp, Pt, Cr, Fe, Co, Cu et Zn. Ce polymère comprend au moins 20 % et de préférence 50 % en poids de métal rapporté au poids du polymère.