baber/WOPTO huggingface dataset:
Patent IL-103939-A0 (IL)
Title: Infectious bursal disease vaccine
IPC: A61K39/395
Filed: 1992-12-01
Abstract: The invention relates to a vaccine for the prevention of Infectious Bursal Disease in poultry comprising an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92052301 (MB), an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92100106 (MB-2), or an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92102209 (MB-1). In addition, the invention relates to a method of preventing Infectious Bursal disease in poultry by administering to the birds an effective immunizing amount of the said vaccines. The invention relates to three novel virus strains deposited at the ECACC under No. V92052301 (MB), under No. V92100106 (MB-2) and under No. V92102209 (MB-1). Furthermore, the invention relates to a method of preparing live vaccines which protect poultry against Infectious Bursal Disease, containing an effective immunizing amount of a virus of the strain deposited at the ECACC under No. V92052301 (MB) and/or No. V92100106 (MB-2) and/or No. V92102209 (MB-1).
Patent IL-111525-A0 (IL)
Title: A method for analyzing glucose in a biological matrix
IPC: A61B5/1455
Filed: 1994-11-03
Abstract: PCT No. PCT/DE94/01290 Sec. 371 Date Feb. 9, 1996 Sec. 102(e) Date Feb. 9, 1996 PCT Filed Oct. 29, 1994 PCT Pub. No. WO95/12348 PCT Pub. Date May 11, 1995Method and apparatus for the analytical determination of glucose concentration in a biological matrix, wherein in a detection step light from a light emitter is irradiated into the biological matrix as primary light via a boundary surface of the biological matrix and light emerging from the the biological matrix through a boundary surface is being detected by a light detector in order to determine a measurable physical light property which is changed by interaction with the biological matrix and which correlates with the glucose concentration of said matrix. The glucose concentration is ascertained in an evaluation step on the basis of said change of the physical light property determined in at least one detection step in comparison with a calibration. In order to achieve by such a method good analytical accuracy in reagent-free and non-invasive manner, for instance to observe the change of the concentration of the analyzed substance (monitoring) over an adequate time interval, a measurable parameter corresponding to the light transit-time within the biological matrix between a defined irradiation site and a defined detection site and correlating with the glucose concentration is determined in the detection step.
Patent IL-134992-A0 (IL)
Title: Noninvasive transdermal systems for detecting analytes
IPC: G01N33/94
Filed: 1998-09-11
Abstract: The present invention relates to noninvasive transdermal systems and methods for analyte extraction from a biological fluid within or beneath the skin, such as interstitial fluid, and detection of the analyte. More particularly, the present invention relates to noninvasive transdermal patches comprised of a wet chemistry component and a dry chemistry component. The wet chemistry component is a liquid transfer medium in the form of a gel layer for the extraction and liquid bridge transfer of the analyte of interest from the biological fluid within or beneath the skin to the dry chemistry component. The dry chemistry component is a super sensitive or conditioned membrane carrying a reagent system for interacting with the analyte of interest to generate an indicator molecule, e.g., color change, to confirm detection of the analyte, and methods of use thereof. The indicator molecule may be visually observed by the individual user or observed by an electronic interpretation component, such as a reflectance spectrophotometer for detection. A particular analyte of interest which may be detected accurately, reliably and quantitatively in accordance with the present invention is glucose. The noninvasive transdermal systems of the present invention are low in-cost and suitable for convenient use by non-medical personnel.
Patent IL-141914-A0 (IL)
Title: Dosage form comprising liquid formulation
IPC: A61K9/14
Filed: 1999-09-03
Abstract: A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.
Patent IL-142055-A0 (IL)
Title: New salts of hmg-coa reductase inhibitors
IPC: C07C211/10
Filed: 1999-09-17
Abstract: Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to  Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor  or  Penicillium  genus, some are obtained by treating the fermentation products using the methods of chemical synthesis or they are the products of total chemical synthesis.  The present invention relates to the new amine salts of HMG-CoA reductase inhibitors, the preparation thereof, the preparation of pure HMG-CoA reductase inhibitors via amine salts thereof, the use of the amine salts of HMG-CoA reductase inhibitors in the process for semisynthetic preparation of HMG-CoA reductase inhibitors, the use of the amine salts of HMG-CoA reductase inhibitors in the process for biotechnological modification of HMG-CoA reductase inhibitors as well as the conversion of the amine salts of HMG-CoA reductase inhibitors into the pharmaceutically acceptable salts of the HMG-CoA reductase inhibitors and the conversion of the amine salts of HMG-CoA reductase inhibitors into the HMG-CoA reductase inhibitors in the lactone form.
Patent IL-142189-A0 (IL)
Title: New heterocyclylmethyl-substituted pyrazol derivatives, processes for their preparation and their use as medicaments
IPC: C07D/
Filed: 2001-03-22
Abstract: 1-(Benzyl or heterocyclylmethyl)-3-(substituted (hetero)aromatic)-fused pyrazole compounds of formula (I) are new. X = O, S NH or CH=CH, and the X-containing ring is optionally substituted by R14; R1 = phenyl, 2-thienyl, 2-pyrrolyl or 2-furanyl, all substituted by R4; R4 = CHOHCH3, 2-6C alkyl (substituted by OH or 1-4C alkoxy), CHO, 1-6C acyl, NO2, 1-6C alkyl (optionally substituted by NH2, N3 or OR5), CH2OR13, or a group of formula (a) or (b); A = phenyl (optionally mono-, di- or trisubstituted by alkyl, alkoxy, alkoxycarbonyl, (each with up to 6C), COOH, NO2, CN, CF3, N3 or halo; R5 = 1-5C acyl, SiR6R7R8, CH2OR10 or a group of formula (c); R6-R8 = 6-10C aryl, 1-6C alkyl; R9, R13 = H or 1-3C alkyl; R10-R12 = H or 1-4C alkyl; R14 = OH, halo, 1-4C alkoxy or 1-4C alkyl; a = 1-3: provided that when R4 = CH2OR13, then A = substituted phenyl where the substituents include alkoxycarbonyl, COOH, NO2, CN, CF3 or N3.
Patent IL-144544-A0 (IL)
Title: Azeotrope-like compositions of 1,1,1,3,3,-pentafluorobutane
IPC: C23G5/028
Filed: 2000-03-22
Abstract: Disclosed are binary azeotrope-like compositions consisting essentially of 1,1,1,3,3-pentafluorobutane (HFC-365mfc) and 1,1,1,2,3,4,4,5,5,5-decafluoropentane (HFC-43-10mee) or nonafluoromethoxybutane. The present invention further includes ternary or quaternary azeotrope-like compositions consisting essentially of 1,1,1,3,3-pentafluorobutane and 1,1,1,2,3,4,4,5,5,5-decafluoropentane or nonafluoromethoxybutane, and additionally trans-1,2-dichloroethylene, n-propyl bromide, acetone, methanol, ethanol or isopropanol.
Patent IL-145479-A0 (IL)
Title: Receptacle for the diffusion of a fragrant liquid
IPC: A61L9/12
Filed: 2000-02-18
Abstract: Herein is described a diffusing receptacle including a neck (5) and a top (2) made of porous material destined to absorb part of a fragrant liquid (4) contained in the receptacle (1), and to diffuse its perfume through evaporation towards the outside ambient, provided with suspension means (3) connected to it, capable of keeping the receptacle (1) in a vertical position with the top (2) facing upwards, the said receptacle being so designed that whatever its position, its centre of gravity (G) and the top (2) are on opposite sides of the area to which the receptacle (1) is connected by these suspension means (3).
Patent IL-145623-A0 (IL)
Title: Method for producing high-purity solutions using gaseous hydrogen fluoride
IPC: C01B7/19
Filed: 2000-03-29
Abstract: The invention relates to a method for producing a high-purity solution that contains hydrogen fluoride or a salt thereof or a mixture of two or more thereof. The inventive method comprises the following step (i): hydrogen fluoride is passed into at least one anhydrous solvant. The method is characterised in that hydrogen fluoride is passed into the at least one anhydrous solvant as a gas or liquid gas or as a mixture of gas and liquid gas.
Patent IL-146708-A0 (IL)
Title: Delayed total release two pulse gastrointestinal drug delivery system
IPC: A61K9/24
Filed: 2000-06-02
Abstract: A two pulse gastrointestinal delivery system is provided. The system comprises a desired agent in combination with a swellable core material, the core being surrounded by an inner coat of a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. The inner coat is additionally surrounded by an outer coat that contains additional amounts of the desired agent. When the delivery device enters the gastrointestinal tract, the outer coat releases the desired agent contained therein and disintegrates, exposing the inner coat. The particulate matter in the inner coat takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. Through these channels liquid enters the core which then swells to the point at which the inner coat is broken. When the integrity of the inner coat is destroyed, the core then disintegrates, immediately releasing all or most of the drug at a specific site. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of both pulses of the drug can be carefully controlled. The invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time-dependent manner.</PTEXT>
Patent IL-154313-A0 (IL)
Title: Teatcup liner series
IPC: A01J5/04
Filed: 2003-02-06
Abstract: A teatcup liner series, having n liners L1 through Ln, has at least one selected parameter which varies liner to liner to provide selectable milking characteristics. The teatcup liner series is produced by a cost advantaged manufacturing method. <IMAGE>
Patent IL-156397-A0 (IL)
Title: Analyte measurement
IPC: G01N27/22
Filed: 2001-12-19
Abstract: A glucose sensor in the form of a skin patch (2) has a microneedle (4) which painlessly penetrates the skin to draw out interstitial fluid. The interstitial fluid passes to a common entrance port (7). A series of microchannels (8) is provided on the patch. The fluid drawn onto the patch is selectively switched between a number of microchannels (8) by means of electro-osmotic pumps (10) and hydrophobic gates (12). Each microchannel (8) has an electrochemical detector (11) for sensing glucose concentration. Also disclosed is a monolithic device with an integrated lance (83).
Patent IL-190932-A0 (IL)
Title: Method for obtaining a biocompatible composite implant
IPC: A61F2/04
Filed: 2008-04-17
Abstract: The method involves selecting a mold (1) related to a desired implant. A solid metal core (7) is arranged in the mold. The available volume of the mold is filled with the powder of microbeads (3). The microbeads are integrated with one another and with the core by electrical discharge machining. The machining is done by a discharge of electric current, of a preset voltage to obtain a surface density of energy less than or equal to 10 joules per square meter between two opposite polarity electrodes (5, 5`). The electrodes are positioned in a manner that the current lines formed between the electrodes are not parallel to the metal core/microbead interface. Independent claims are also included for the following: (1) a dental implant (2) an implant destined to the thyroplasty (3) an implant destined to replace a mandible (4) an implant destined to replace a trachea.
Patent IL-205748-A0 (IL)
Title: Vegf polymorphisms and anti-angiogenesis therapy
Filed: 2010-05-13
Abstract: Methods for determining whether a patient in at particular risk of hypertension associated with anti-VEGF treatment or has a greater likelihood of benefiting from anti-VEGF therapy by screening a sample isolated from the patient for specific genomic polymorphisms.
Patent IL-209189-A0 (IL)
Title: Copolymer 1 related polypeptides and their use as molecular weight markers
IPC: A61K38/00
Filed: 2010-11-07
Abstract: The present invention provides molecular weight markers for accurate determination of the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases.
Patent RO-126412-A0 (RO)
Title: Isothermal stove plate working according to the thermal flat tube principle
Inventor: DUDIŢĂ MIHAELA
IPC: C23C14/50
Filed: 2011-02-14
Abstract: The invention relates to an isothermal stove plate working according to the thermal flat tube principle meant for the applications requiring a uniform temperature distribution on the working surface, for example, within the field of the thin layer deposition by the process of atomization with pyrolysis, for heating uniformly the substrate and maintaining constant the temperature thereof during the whole thin layer depositing period. According to the invention, the stove plate consists of an upper component (1) imperviously fixed to a lower component (2), between the upper component (1) and the lower component (2) inside a formed enclosure (3) there being provided some stiffening columns (4) which ensure the constant maintenance of the distance between the two components (1 and 2) on the surfaces inside the enclosure of the two components (1 and 2), each having machined a network (a) of horizontal channels or a network (b) of vertical channels, with the role of increasing the specific evaporation and condensing surface, the lower component (2) having also the role of reservoir for a working fluid (5), which carries out a thermodynamic vaporization-condensing cycle, according to the operation principle of the thermal flat tube, outside, at the bottom or on the sides, or both at the bottom and on the sides, there being assembled a casing (6) wherein there are some electrical resistors or any other heat source controlled by means of a system (7) for the automatic temperature control, which uses some temperature sensors (c) located at the upper side of the stove plate, the lower component (2) being provided on each of its side walls with some orifices (d) communicating with the outside, wherein there may be assembled a device (8) which allows to perform the filling, aerating and vacuuming operations, as well as a safety valve (9).
Patent IE-910978-A1 (IE)
Title: 2-(substituted pyrrolidinylthio)carbapenem derivatives
IPC: C07D477/20
Filed: 1991-03-25
Abstract: A compound of the formula: <CHEM> wherein R is a hydrogen atom or a methyl group, R<1> is a hydrogen atom or a negative charge, each of R<2> and R<3> which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, -COOR<4>, -CON(R<5>)R<6>, -N(R<5>)R<6>, -CH2COOR<4>, -CH2N(R<5>)R<6> or -CH2CON(R<5>)R<6> (wherein R<4> is a hydrogen atom or a lower alkyl group, each of R<5> and R<6> which may be the same or different, is a hydrogen atom or a lower alkyl group, or R<5> and R<6> form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group and a piperidyl group), A is =NR<7>, =N/<+>(R<7>)R<8>, -CON(R<7>)-, -CON(R<7>)CO-, -CON(R<7>)CON(R<8>)-, -N(R<7>)CO(CH2)sN(R<8>)-, -N(R<7>)CO(CH2)sCON(R<8>)-, -CON(R<7>)N(R<8>)- or -N(R<7>)(CH2)sN(R<8>)- {wherein each of R<7> and R<8> which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, -COOR<4>, -CON(R<5>)R<6>, -N(R<5>)R<6>, -CH2COOR<4>, -CH2N(R<5>)R<6> or -CH2CON(R<5>)R<6> (wherein R<4>, R<5> and R<6> are as defined above), s is an integer of from 1 to 3}, p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q + r </= 6; or a pharmaceutically acceptable salt or ester thereof.
Patent MA-20790-A1 (MA)
IPC: A61F13/15
Filed: 1986-10-10
Abstract: An integral disposable absorbent article such as a diaper having a liquid pervious topsheet, a liquid impervious backsheet, an absorbent core disposed between the topsheet and the backsheet, at least one elastically contractible gasketing cuff, and at least one barrier cuff. The barrier cuff has a proximal edge and a distal edge. The absorbent article is additionally provided with spacing means for spacing the distal edge away from the top surface of the topsheet. In addition, adhesive means secure the end portions of the barrier cuff closed. A channel is formed between the proximal and distal edges in at least the crotch region because the distal edge is spaced away from the topsheet top surface.When the diaper embodiment of the present invention is applied to a wearer, the barrier cuff rides up along the inner thighs and the perineum of the wearer in the crotch region and along the buttocks in the back waist region. Leakage prevention is enhanced because body exudates which are not immediately absorbed by the absorbent core contact the barrier cuff and are contained and held within the channel so that they do not wick out of the diaper or flow out of the gaps between the diaper and the legs or waist of the wearer. Additionally, should such exudates flow beyond the barrier cuff, leakage is further enhanced by the gasketing cuff because it forms an additional fluid impervious barrier about the leg or waist of the wearer.
Patent MA-28238-A1 (MA)
Inventor: GALLI FREDERIC
IPC: C07D519/00
Filed: 2006-06-22
Abstract: 4-heterocyclylcarbonyl-1,4-diazacyclo-octane derivatives (I), as individual or mixed enantiomers, bases, solvates and acid addition salts are new. 4-heterocyclylcarbonyl-1,4-diazacyclo-octane derivatives of formula (I), as individual or mixed enantiomers, bases, solvates and acid addition salts are new. X : N or CR 2; P, Q, R and W : N or CR 3; R 1 and R 21-6C alkyl; R 3hydrogen, halo, 1-6C alkyl or alkoxy, nitro, amino, trifluoromethyl, cyano, NR 4R 5, NR 4COR 5, NR 4CONR 5R 6, NR 4COOR 5, NR 4SO 2NR 5R 6, OR 5, OCOR 5, OCOOR 5, OCO-ONR 4R 5. OCOSR 5, COOR 5, COR 5, CONR 4R 5, SR 5, SOR 5, SO 2R 5, SO 2NR 4R 6, or phenyl (optionally substituted by any of the groups indicated for R 3), or R 3 is any of a wide range of heterocyclic groups (het1); R 4, R 5 and R 6halo, 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-8C cycloalkyl, 3-8C cycloalkyl(1-3C)alkyl, 4-8C cycloalkenyl or phenyl, and RNR 4R 5 or NR 5R 6 may complete a heterocycle (het2). The full definitions are given in the DEFINITIONS (Full Definitions) Field. [Image] ACTIVITY : Nootropic; Neuroprotective; Neuroleptic; Antiparkinsonian; Anticonvulsant; Tranquilizer; Antidepressant; Cardiant; Antiulcer; Antismoking. MECHANISM OF ACTION : (I) are ligands for nicotinic receptors, with high selectivity for receptors that include the alpha 7 subunit. The compound 3-(1,4-diazabicyclo[3,2,1]oct-4-yl-carbonyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine hydrobromide had IC 50 for inhibition of binding of tritium-labeled alpha -bungarotoxin to nicotinic receptors that contained the alpha 7 subunit of 0.056 mu M.
Patent MA-39021-A1 (MA)
Title: Compositions de collecteurs et leurs procédés de fabrication et d'utilisation
Inventor: HINES JOHN B
IPC: B03D1/01
Filed: 2016-05-05
Abstract: L'invention concerne des compositions de collecteurs et leurs procédés de fabrication et d'utilisation pour purifier au moins une matière brute. La composition de collecteurs peut contenir une ou plusieurs amidoamines possédant la formule chimique i et une ou plusieurs amines possédant la formule chimique iv, un rapport de poids amidoamine/amine pouvant être compris entre environ 99:1 et environ 1:99.
Patent MA-49600-A1 (MA)
Title: Un écosystème réactif d’analytique des trajectoires complexes, de pilotage opérationnel,de prédiction et de monitoring spatio-temporel de propagation d’infodémie et d’agents infectieux
Inventor: BOULMAKOUL AZEDINE
IPC: G06Q50/26
Filed: 2020-04-27
Abstract: De nos jours, les problèmes de santé publique ont pris une considération importante dans notre société, en particulier la propagation virale dans les zones peuplées. Les épidémies se réfèrent à une maladie qui se propage de manière extensive et rapide par infection et qui affecte de nombreux individus dans une zone. En 2020, l’exemple de covi-19 a généré un chaos sur la planète, où plus d’un tiers de la population mondiale appelé à se confiner.
Patent MA-51972-A1 (MA)
Title: Dispositif coulissant de siège de véhicule doté d'un ensemble de libération amélioré
Inventor: SPAGNOLI LUIGI
IPC: B60N2/08
Filed: 2019-04-17
Abstract: La présente invention concerne un dispositif coulissant d'un siège de véhicule doté d'un ensemble de libération amélioré. Le dispositif coulissant comprend deux ensembles de verrouillage (1a, 1b), comprenant chacun une pluralité de broches de verrouillage (3a, 3b) servant à verrouiller les rails supérieurs du dispositif coulissant aux rails inférieurs respectifs. Ledit dispositif coulissant comprend un ensemble de libération servant à entraîner lesdites broches de verrouillage dans une configuration de déverrouillage permettant de régler la position du siège. Un tel ensemble de libération (50) comprend un élément de libération (9) comportant deux bras (9a, 9b) reliés pivotants à des rails respectifs du dispositif coulissant, une barre transversale (13) pourvue, à chaque extrémité, d'un ensemble de mise en prise servant à mettre en prise les broches de verrouillage de l'ensemble de verrouillage respectif et deux éléments de liaison (11a, 11b), conçus pour convertir un mouvement de rotation de la partie d'extrémité desdits bras d'élément de libération en un mouvement de translation de la barre transversale.
Patent UY-24343-A1 (UY)
Title: Aparato abastecedor de hilo con control electronico
Inventor: LEINS EBERHARD
IPC: D04B15/48
Filed: 1996-10-04
Abstract: Dispositivo usado en particular para máquinas de tejido de punto con necesidades muy variables en el tiempo. El dispositivo presenta una rueda de hilo accionada por un motor que abastece directamente a la máquina de tejido de punto o a su guía de hilo. La tensión de hilo se controla por medio de un sensor que registra el valor de medida de un regulador que controla el abastecimiento por la rueda de hilo. El regulador es tal que puede procesar información acerca de la necesidad futura de hilo. De esta manera, puede reaccionar anticipadamente, mediante una cesión anticipada o una detención de la cesión, cuando aparecen variaciones repentinas de necesidad de hilo; se pueden controlar los picos y caídas agudas de tensión. Para ello, el reguladoe puede estar desarrollado de manera que pueda trabajar, temporalmente, como contro. Tambien son posibles otras medidas como circuirçtos de regulación de magnitudes perturbadoras, adaptación de parámetros o similares