baber/WOPTO huggingface dataset:
Patent EP-2333543-A1 (EP)
Title: Analysis of HIV-1 coreceptor use in the clinical care of HIV-1 infected patients
Inventor: PHILPOTT SEAN
IPC: G01N33/50
Filed: 2001-09-25
Abstract: A change in viral tropism occurs in many HIV positive individuals over tiem and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus can be shifted back to CCR5- mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CXCCR4 specific strains. The diagnostic method can be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time.
Patent EP-2340822-A1 (EP)
Inventor: STUERZEBECHER JOERG
IPC: A61K31/401
Filed: 2004-01-15
Abstract: Use of acylated 4-(amidino or guanidino)benzylamine derivatives (I) for inhibition of plasma kallikrein (PK). Use of acylated 4-(amidino or guanidino)benzylamine derivatives of formula (I) for inhibition of plasma kallikrein (PK). P4-P3-P2-P1 (I) P4 : benzylsulfonyl, optionally substituted one or more times; P3 : natural or unnatural alpha -amino acid (aaa) or alpha -imino acid (aia) with D configuration, optionally substituted one or more times; P2 : natural or unnatural alpha -amino acid (aaa) or alpha -imino acid (aia) with L configuration, optionally substituted one or more times; P1 : 4-(amidino or guanidino)benzylamino group, optionally substituted one or more times. Independent claims are also included for the following: (1) (I) when (non-)covalently linked to a synthetic surface; (2) synthetic surface to which (I) is (non-)covalently bonded; and (3) instruments that contain the surface of (2). ACTIVITY : Anticoagulant; Thrombolytic; Cardiant; Cerebroprotective; Antianginal; Antibacterial; Immunosuppressive; Antiallergic; Antiarthritic. 3-(glutarylaminomethyl)-benzylsulfonyl-D-Cha-Pro-4-aminobenzylamine as trifluoroacetate (Cha = cyclohexylalanine) had inhibition constant (by the method of J. Med. Chem., 40 (1997) 3091) 0.044 MicroM for PK and below 0.001 MicroM for thrombin. MECHANISM OF ACTION : Inhibition of plasma kallikrein and other trypsin-like serine proteases, e.g. thrombin; activated factors Xa, XIIa, VIIa or IXa; urokinase; tryptase and plasmin; also serine proteases of the complement system.
Patent EP-2209121-A1 (EP)
Inventor: TSUJIMOTO SATOSHI
IPC: G11B27/32
Filed: 2010-01-15
Abstract: An optical disk device includes a reproduction component, an output component and a control component. The reproduction component directs a laser beam at an optical disk that is loaded in the optical disk device with the optical disk storing a plurality of audio data streams in a plurality of different acoustic qualities. The reproduction component reproduces one of the audio data streams. The output component outputs the one of the audio data streams to an amplifier. The control component acquires from the amplifier first audio format information indicating audio formats to which the amplifier corresponds, and acquires from the reproduction component second audio format information indicating audio formats of the audio data streams stored in the optical disk. The control component determines the one of the audio data streams with an audio format that belongs to both the first audio format information and the second audio format information.
Patent EP-2388049-A1 (EP)
Inventor: MENGER EDWIN KRISTIAN
IPC: A63B37/12
Filed: 2010-05-20
Abstract: A toy object is presented which may be used in playing dexterity games. The toy object is shaped as a body of revolution, comprising a central disc shaped part and two opposite, mirror image tapering parts joining the central disc shaped part. It is possible that each tapering part has a frusto-conical shape with a planar top. This allows a number of toy objects to be combined into a stack of toy objects one on top of the other. Further it is preferred that the frusto-conical tapering part apart from its planar top has a concave surface. But also other shapes are possible. The dimensions may vary.
Patent EP-2256528-A1 (EP)
Inventor: PUSHKARSKY MICHAEL
IPC: G01S7/495
Filed: 2010-05-21
Abstract: An optical fiber switch (16) for alternatively directing an input beam (14) to a plurality of different locations (18A) (18B) (18C) (18D) includes an input fiber (30), a redirector (32), a redirector mover (382), a first output fiber (34), and a second output fiber (36). The input fiber (30) launches the input beam (14) along an input axis (30A). The redirector (32) is positioned in the path of the input beam (14). The redirector (32) redirects the input beam (14) so that a redirected beam (42) launches from the redirector (32) along a first redirected axis (360) that is spaced apart from the input axis (30A) when the redirector (32) is positioned at a first position (346), and launches from the redirector (32) along a second redirected axis (362) that is spaced apart from the input axis (30A) when the redirector (32) is positioned at a second position (348) that is different from the first position (346). The redirector mover (382) moves the redirector (32) about a movement axis (386) between the first position (346) and the second position (348). The first output fiber (34) has a first fiber inlet (34B) that is positioned along the first redirected axis (360). The second output fiber (36) has a second fiber inlet (36B) that is positioned along the second redirected axis (362).
Patent EP-2322653-A1 (EP)
Inventor: BENTWICH ITZHAK
IPC: C12Q1/68
Filed: 2005-05-14
Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
Patent EP-2446910-A1 (EP)
Inventor: NEUMANN DR HANS-JUERGEN
IPC: A61M5/142
Filed: 2010-10-27
Abstract: The pump (1) has an actuator device (4) for moving three sections (31-33) of a flexible wall i.e. membrane, of a hollow body (3) from an initial position into an end position during operation of the pump. The device moves a fourth section of the wall (34) from an initial position into an end position. The device moves the third section into the end position when the first and fourth sections are moved into the end position for generating an allowable reproducible pressure in a conveyor chamber so that fluid (2) is pushed into the chamber by the movement of the third section. Independent claims are also included for the following: (1) a hollow body comprising a flexible wall (2) a method for conveying fluid into a hollow body.
Patent EP-2282308-A1 (EP)
Inventor: NGUYEN PATRICK T M
IPC: G06F9/44
Filed: 2005-07-06
Abstract: For constructing a multi-slot dialog with a user to obtain multiple items of information over a number of turns, it is provided at least one slot segment object, each slot segment object containing a corresponding set of slot objects, each representing a slot in a segment, each slot representing an item of information to be provided by the user; it is further provided at least one set of slot group objects for each slot segment object, each slot group object defining parameters associated with a particular combination of slots in the slot segment object; and it is executed a multi-slot dialog flow defined by dialog objects.
Patent EP-2432070-A1 (EP)
Inventor: YASSINI BAHRAM
IPC: H01P1/208
Filed: 2010-11-09
Abstract: A microwave cavity filter (100) is configured for operation in the dual TE 22N  mode to realize a very high Q factor at very high frequency ranges. The microwave filter is formed from using one or more cylindrical cavities (60a,60b) in which two orthogonal field polarizations of the TE 22N  mode are excited and coupled together by means of a coupling element (78a,79b). Different combinations of inter-cavity irises (84,90) provide for both direct and cross-coupling of aligned field polarizations in adjacent cavities, as required, to realize complex filter functions. The irises may be formed in either a side or end wall of the cavities for both collinear and planar mount configuration. Negative mode coupling also allows for transmission zeros to be realized on either side of the filter passband.
Patent EP-2463888-A1 (EP)
Inventor: VAN HOFTEN GERALD
IPC: H01J37/22
Filed: 2010-12-07
Abstract: In a direct electron detector, backscattering of electrons into the detector volume from below the sensor is prevented. In some embodiments, an empty space is maintained below the sensor. In other embodiments, a structure below the sensor includes geometry, such as multiple high aspects ratio channels, either extending to or from the sensor to trap electrons, or a structure of angled surfaces to deflect the electrons that pass through the sensor.
Patent EP-2330109-A1 (EP)
Inventor: LEI XINJIAN
IPC: C07F7/00
Filed: 2010-12-07
Abstract: The present invention relates to a family of liquid group 4 precursors represented by the formula: (pyr*)M(OR 1 )(OR 2 )(OR 3 ), wherein pyr* is an alkyl substituted pyrrolyl, M is a group 4 metal, and R 1-3  can be same or different and are selected from linear or branched C 1-6  alkyls. It also relates to a family of Group 4 precursors represented by the formula: (pyr*)(Cp)M(OR 1 )(OR 2 ), wherein pyr* is an alkyl substituted pyrrolyl, Cp is cyclopentadienyl or alkyl substituted cyclopentadienyl, and M and R 1-2  are as previously defined. Preferred precursors include: (2,5-di-tert-butylpyrrolyl)(tris(ethoxy)titanium; (2,5-di-tert-amylpyrrolyl)(tris(ethoxy)titanium; (2,5-di-tert-amylpyrrolyl)(tris(iso-propoxy)titanium; and (cyclopentadienyl)(2,5-dimethylpyrrolyl)(bis(ethoxy))titanium.
Patent EP-2463039-A1 (EP)
Inventor: ENDO KENICHI
IPC: B21D43/05
Filed: 2010-12-09
Abstract: A tandem press system (1) includes a plurality of presses (10U,10D) disposed in a workpiece transfer direction (X), a workpiece transfer device (20) that transfers a workpiece from an upstream press (10U) to a downstream press (10D) using a tool (65) mounted on the workpiece transfer device (20) via a crossbar (61), and a tool replacement device (30) that replaces the tool (65) mounted on the workpiece transfer device (20). The tool replacement device (30) can be transferred from an inter-press space (11) between the upstream press (10U) and the downstream press (10D) to an external space (105) in a tool replacement direction (Y t ) independently of transfer of a bolster (14) provided with a die to an external space (104) in a die replacement direction (Y d ).
Patent EP-2345911-A1 (EP)
Inventor: KIM SUNG YOON
IPC: G01S15/89
Filed: 2010-12-22
Abstract: Embodiments for providing at least one slice image based on at least three points are disclosed. In one embodiment, by way of non-limiting example, an ultrasound system (100) comprises: an ultrasound data acquisition unit (110) configured to transmit and receive ultrasound signals to and from a target object to output ultrasound data; a user input unit (120) configured to receive input information for setting at least three points on a three-dimensional ultrasound image from a user; and a processing unit (130) in communication with the ultrasound data acquisition unit and the user input unit, the processing unit being configured to form volume data based on the ultrasound data, render the volume data to form the three-dimensional ultrasound image, set the at least three points on the three-dimensional ultrasound image based on the input information, set at least one slice on the three-dimensional ultrasound image based on the at least three points and form at least one slice image corresponding to the at least one slice.
Patent EP-2339474-A1 (EP)
Inventor: YAMAZAKI IWAO
IPC: G06F12/08
Filed: 2010-12-22
Abstract: A cache unit comprising a register file that selects an entry indicated by a cache index of n bits (n is a natural number) that is used to search for an instruction cache tag, using multiplexer groups having n stages respectively corresponding to the n bits of the cache index. Among the multiplexer groups having n stages, a multiplexer group in an m th  stage has 2 (m-1)  multiplex circuits. The multiplexer group in the m th  stage uses a value of an m th  bit (m is a natural number equal to or less than n) from the least significant bit in the cache index as a control signal. The multiplexer group in the m th  stage switches all multiplex circuits included in the multiplexer group in the m th  stage in accordance with the control signal.
Patent EP-2281913-A1 (EP)
Inventor: STROCK CHRISTOPHER W
IPC: C23C4/04
Filed: 2010-08-03
Abstract: A coated article (100;132) has a metallic substrate (200). A coating layer (206) comprises at least 33% by volume ceramic, at least 5% by volume of a lubricant selected from the group consisting of hexagonal boron nitride (hBN), clay, graphite, and mixtures thereof. The coating layer (206) lacks a metal phase of more than 5% by volume.
Patent EP-2468756-A1 (EP)
Inventor: LACHAUD CHRISTOPHE
IPC: C07F3/00
Filed: 2010-12-07
Abstract: A strontium source precursor, comprising a diazacrown ligand, Sr[-N-C(R 1  R 2 )C(R 3 R 4 )-O-C(R 5  R 6 )C(R 7  R 8 )-O-C(R 9  R 10 )C(R 11  R 12 )-] 2  of formula (I):
     
wherein: 
R 1 -R 12  are organic ligands independently selected in the group consisting of H, a linear or branched function alkyl, aryl, alkenyl, alkylsilyl, alkylamides, alkylsilylamides, alkoxide, fluoroalkyl comprising from 1 to 5 atom of carbon
Patent EP-2345354-A1 (EP)
Inventor: ULLMANN ERICH
IPC: A47J31/46
Filed: 2010-01-19
Abstract: The device (10) has a housing (11) partially surrounding a liquid line group (22). A mixing device (52) is provided in a predetermined position relative to a fluid line. The housing is provided with housing parts (12, 14). The liquid line group is formed at one of the housing parts. A recess for receiving the mixing device is formed in another housing part. The housing parts are plugged together such that the mixing device takes a predetermined position relative to the fluid line, if the mixing device is accommodated in a recess in the latter housing part. An independent claim is also included for a method for assembling a delivery device.
Patent EP-2376481-A1 (EP)
Title: Dérivés de pyrimidine carboxamide comme inhibiteurs de la kinase syk
Inventor: ATKINSON FRANCIS LOUIS
IPC: A61P35/00
Filed: 2010-01-11
Abstract: La présente invention concerne le composé de formule (I) ou un sel, de préférence un sel pharmaceutiquement acceptable, de celui-ci; qui est un inhibiteur de la tyrosine kinase splénique (spleen tyrosine kinase : SYK) et qui peut être potentiellement utilisé pour traiter des maladies résultant d'une activation inappropriée des cellules mastocytes, par exemple des maladies allergiques et inflammatoires, mais également potentiellement utilisé dans une thérapie du cancer, en particulier des malignités héminiques.
Patent EP-2525751-A1 (EP)
Title: Bouchon d'oreille pour prothèse auditive avec cordonnet d'extraction
Inventor: VAARBROE KLAUS HENRIK
IPC: H04R25/00
Filed: 2010-01-19
Abstract: La présente invention concerne un bouchon d'oreille (1) pour prothèse auditive, constitué d'un matériau résilient et doté d'un cordonnet d'extraction (4) sur lequel l'utilisateur pourra tirer pour extraire facilement ledit bouchon d'oreille (1) de son conduit auditif externe. Ledit cordonnet d'extraction (4) est, pour partie, disposé dans le matériau résilient et, pour partie, hors du bouchon d'oreille. Un renflement servant à la fixation (6) du cordonnet est disposé sur la partie du cordonnet d'extraction se trouvant dans le matériau résilient, et permet de maintenir le cordonnet d'extraction en place dans le matériau résilient. Le cordonnet d'extraction est fixé au matériau résilient. L'invention concerne également un procédé de fabrication dudit bouchon d'oreille.
Patent EP-2393377-A1 (EP)
Title: Procédé de préparation de chocolat en pain
Inventor: GODFREY GRAHAM
IPC: A23G1/00
Filed: 2010-02-03
Abstract: La présente invention concerne un procédé de fabrication de chocolat en pain, et un appareil de préparation de chocolat en pain. Le procédé consiste à: utiliser un mélange de lait et de sucre ou à mélanger ensemble du lait et du sucre de façon à constituer un mélange dans une cuve de réaction; b) évacuer du mélange, par évaporation, le liquide en excès présent dans la cuve de réaction de façon à former un lait condensé sucré; c) ajouter du cacao en pâte/de la liqueur de cacao dans la cuve de réaction pendant et/ou après l'étape a) et/ou l'étape b); d) placer le mélange présent dans la cuve de réaction dans des conditions propres à provoquer la cristallisation du sucre dans le mélange; et e) sécher le mélange de façon à former un chocolat en pain. Le procédé est efficace en ce que l'évaporation initiale du liquide en excès a lieu dans la même cuve de réaction utilisée pour mélanger et traiter les constituants du chocolat en pain. Dans un mode de réalisation, toutes les étapes, de a) à e), sont réalisées dans une seule et même cuve de réaction.
Patent EP-2373663-A1 (EP)
Title: Thiénopyridines servant de principes actifs pharmacologiques
Inventor: BOYAPATI SHIREESHA
IPC: A61P19/02
Filed: 2010-01-05
Abstract: L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des procédés pour synthétiser des thiénopyridines et des procédés pour inhiber l'activité du TNF-α pour le traitement du cancer, de l'asthme, de l'arthrite, du diabète et des inflammations.
Patent EP-2531735-A1 (EP)
Inventor: TADDIA LUCA
IPC: F15B11/16
Filed: 2010-02-02
Abstract: Hydraulic section (1) comprising: a main spool (2); pressure compensation means (16) able to maintain a substantially constant pressure drop through a metering orifice (3) of said main spool (2); a first chamber (7) interposed between said main spool (2) and a first end (16a) of said compensation means (16); a second chamber (6) situated at a second end (16b) of said compensation means (16), said second chamber (6) being connectable to a feed line (Pal) from a pump (100) by means of a predefined channel (Pp) in such a way that said hydraulic section (1) operates as a priority section, or being connectable to a line (LS) for detecting the highest load pressure in such a way that said hydraulic section (1) operates as a flow-sharing section.
Patent EP-2550713-A1 (EP)
Title: Disjoncteur hybride
Inventor: DEMETRIADES GEORGIOS
IPC: H01H9/54
Filed: 2010-03-26
Abstract: L'invention concerne un disjoncteur hybride (1) servant à interrompre un courant défaillant dans une ligne de circuit électrique comportant une impédance de ligne (Z). Le disjoncteur hybride comprend un disjoncteur mécanique (S méc ) conçu pour interrompre la ligne lorsqu'un courant défaillant est détecté; un dispositif semi-conducteur (G 1 , G 2 , V), installé en parallèle par rapport au disjoncteur mécanique, pour conduire le courant défaillant quand le disjoncteur mécanique est déconnecté; une branche (3), connectée entre la ligne de circuit électrique et la masse et qui comprend une unité d'impédance (5, R); et une unité de commande (4), conçue pour connecter l'unité d'impédance (5, R) en parallèle avec l'impédance de ligne (Z) quand le courant défaillant est détecté.
Patent EP-2414320-A1 (EP)
Title: Procédé de diméthylation de groupes méthylène actifs
Inventor: JENKO BRANKO
IPC: C07C253/30
Filed: 2010-03-30
Abstract: Cette invention concerne un procédé de diméthylation de groupes méthylène actifs. Plus spécifiquement, cette invention concerne un procédé de préparation d'un 3-amino-2,2-diméthylpropanamide. Les composés produits par le présent procédé de diméthylation tels que le 3-amino-2,2-diméthyl- propanamide peuvent être utilisés comme intermédiaires dans la voie de synthèse d'un agent thérapeutique, prophylactique ou diagnostique, par exemple, l'aliskiren ou la cryptophycine. En particulier, cette invention concerne des modes de réalisation s'étendant, en outre, à des procédés de préparation de formes pharmaceutiques comprenant lesdits agents thérapeutiques, prophylactiques ou diagnostiques. Plus spécifiquement, l'invention concerne l'utilisation des composés produits par le présent procédé de diméthylation pour la fabrication d'agents thérapeutiques, prophylactiques ou diagnostiques ou pour la fabrication de formes pharmaceutiques comprenant lesdits agents thérapeutiques, prophylactiques ou diagnostiques. Les procédés selon la présente invention peuvent être appliqués de manière bénéfique à la synthèse de divers principes pharmaceutiques actifs, tels que l'aliskiren ou la cryptophycine.
Patent EP-2421824-A1 (EP)
Inventor: BIAN HAIYAN
IPC: C07D401/10
Filed: 2010-04-22
Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) wherein Y, Z, R1, and s are defined herein.
Patent EP-2425191-A1 (EP)
Inventor: COUSIN FRANCK
IPC: F25D3/12
Filed: 2010-04-15
Abstract: L'invention a pour objet un procédé de mélange et de refroidissement d'un produit, durant lequel on vient déposer dans un réceptacle, de façon simultanée, le produit et de la neige carbonique, de façon homogène, ce caractérisant en ce que l'on met en oeuvre un tromblon équipé d'une double enveloppe extérieure, le produit à refroidir passant dans la double enveloppe extérieure tandis que la neige carbonique est produite et extraite par l'intérieur du tromblon, le produit tombant ainsi dans le réceptacle en même temps que la neige, qui se sublime et qui transfert ses frigories au produit.
Patent EP-2576646-A1 (EP)
Inventor: GRIJPMA DIRK WYBE
IPC: C08F299/02
Filed: 2010-05-26
Abstract: The present invention relates to methods for preparing a degradable polymer network. The methods for preparing a degradable polymer network comprise a) preparing a polymer composition comprising monomers of cyclic carbonates and/or cyclic esters and/or linear carbonates and/or linear esters and/or cyclic ethers and/or linear hydroxycarboxylic acids at a temperature between 20°C and 200 °C; b) adding a cross-linking reagent comprising at least one double or triple C-C bond and/or a cross-linking radical initiator; c) processing the polymer composition (that contains the crosslinking reagentj into a desired shape; d) Crosslinking by irradiating the mixture. Further, the present invention relates to a degradable polymer network. Furthermore, the present invention relates to the use of the degradable polymer network.