Patent SG-11201909726Y-A (SG)
Title: METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF
Inventor: JACOBSEN THOMAS
IPC: A61K31/167
Filed: 2018-04-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT o mum I E l0 00111101101110 011 (10) International Publication Number WO 2018/193099 Al (51) International Patent Classification: A61K 9/08 (2006.01) A61K 31/192 (2006.01) A61K 31/167 (2006.01) (21) International Application Number: Published: — with international search report (Art. 21(3)) PCT/EP2018/060205 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2017/059440 20 April 2017 (20.04.2017) EP (71) Applicant: HYLORIS DEVELOPMENTS SA [BE/BE]; Avenue Hippocrate 5, 4000 Liege (BE). (72) Inventor: JACOBSEN, Thomas; Avenue Hippocrate 5, 4000 Liege (BE). (74) Agent: BRANTSANDPATENTS BVBA; Pauline Van Pottelsberghelaan 24, 9051 Ghent (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) ON (54) Title: METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ON ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF O M (57) : The present invention provides a method for preparing an intravenously administrable aqueous composition comprising CN acetaminophen, and optionally one or more non-steroidal anti-inflammatory drugs (NSAIDs), whereby the dissolved oxygen of the 1-1 composition in a closed container is maximally 1.0 ppm, said method comprises rinsingat least once a compounding vessel with water of a temperature of at least 80°C, thereby heating the vessel and creating an oxygen low environment in said vessel; and in said rinsed 1-1 c;;;;) vessel dissolving acetaminophen in water for injection, said water for injection is at a temperature of at least 80°C, whereby optionally N one or more NSAIDS are added prior or after dissolving of acetaminophen.