baber/WOPTO huggingface dataset:
Patent CA-2460360-A1 (CA)
Title: Systematical administration of some oxazolidinones, e.g. linezolid, for the treatment for ocular infections
Inventor: SLATTER J GREG
IPC: A61P31/04
Filed: 2002-09-11
Abstract: The invention provides a method for treating ocular infections such as endophthalmitis, comprising the systematical administration of some oxazolidinones, e.g. linezolid.
Patent CA-2460964-A1 (CA)
Title: Coordinating whether the graphical user interface of a set top box or that of a digital video recorder is displayed
Inventor: PRICE WILLIAM P
IPC: H04N21/436
Filed: 2002-09-18
Abstract: A digital video recorder (DVR 12) for use with a monitor (14) and a set top box (16), wherein the STB tunes to channels and comprises a DVR interface, wherein the DVR comprises a memory for storing program data from the STB, wherein the DRV controller communicates to the STB to tune to the available channels.
Patent CA-2462259-A1 (CA)
Title: Mammalian cell-infecting virus vector encoding epitope-bound .beta.2m and utilization thereof
Inventor: TACHIKAWA AI
IPC: C12N15/86
Filed: 2002-09-20
Abstract: A mammalian cell-infecting virus vector encoding epitope-bound .beta.2m is constructed and thus the epitope-bound .beta.2m is successfully expressed in a large amount in mammalian cells. Namely, it is intended to provide a mammalian cell-infecting virus vector encoding epitope-bound .beta.2 microglobulin (.beta.2m) and utilization thereof. Also, a process for producing an MHC class I/peptide complex with the use of the vector is provided. In particular, a tetramerized MHC class I/peptide complex is useful in detecting epitope-specific CD8-positive T cells. Cells having the above vector transferred thereinto are also provided. Moreover, target cells having epitope-bound .beta.2m produced by the above-described vector added thereto are provided.  These cells are recognized by antigen-specific cytotoxic T lymphocytes (CTL).  The above vector and the polypeptide obtained via the expression of the vector are useful in immunotherapy for infection and cancer and detection and quantification of antigen-specific CTL.
Patent CA-2462514-A1 (CA)
Title: Dicarboxylic acid derivatives, their preparation and therapeutical use
Inventor: MOGENSEN JOHN PATRICK
IPC: A61K31/194
Filed: 2002-10-15
Abstract: A novel class of dicarboxylic acid derivatives, the use of these compounds a s phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Prolifera-tor-Activated Receptors (PPAR).
Patent CA-2463933-A1 (CA)
Inventor: DRISCOLL MARK D
IPC: C12Q1/68
Filed: 2002-10-15
Abstract: L'invention se rapporte à des compositions et à un procédé d'amplification de séquences d'acides nucléiques d'intérêt. Ledit procédé consiste généralement à répliquer une séquence cible de manière que, lors de la réplication, les brins répliqués soient déplacés de leur séquence cible par réplication du déplacement de brin d'un autre brin répliqué. Dans un aspect dudit procédé, l'échantillon cible n'est pas soumis à des conditions de dénaturation. On a découvert que les acides nucléiques cibles, l'ADN génomique, par exemple, n'avaient pas besoin d'être dénaturés pour de meilleures amplifications de déplacement. Les amorces utilisées peuvent être des amorces hexamères ; elles peuvent également contenir chacune au moins un nucléotide modifié afin que les amorces résistent aux nucléases. Lesdites amorces peuvent aussi contenir chacune au moins un nucléotide modifié afin que la température de fusion de l'amorce soit modifiée par rapport à une amorce de la même séquence sans le(s) nucléotide(s) modifié(s). L'ADN polymérase peut être l'ADN polymérase .phi.29.
Patent CA-2464557-A1 (CA)
Inventor: LOPEZ JONATHAN
IPC: B65B13/32
Filed: 2004-04-15
Abstract: A strapping head for a strapping machine includes a novel anvil arrangement having an offset connecting link for translating eccentric drive movement to linear oscillations for effecting strapping welds. The strapping head includes a stationary body, an anvil mounted to the body. A sealing member is disposed in a slot in the anvil. The sealing member oscillates in a longitudinal direction and is restrained from movement in a direction transverse to the longitudinal direction. The offset link operably connects the drive and the sealing member. The link has a first element adapted to receive an eccentric movement and a second element adapted to deliver a linear oscillating movement. The first and second elements are operably connected to one another by a connecting pin. The first and second element lie on different planes to permit ready removal of the sealing member from the anvil slot.
Patent CA-2464611-A1 (CA)
Title: Electric discharge machining electrode and method
Inventor: CURODEAU ALAIN
IPC: B23H1/08
Filed: 2002-11-19
Abstract: A method for electric discharge machining (EDM) with a ductile carbonaceous electrode, to automate roughing, finishing, polishing and texturing operations on a electrically conductive material. The EDM method comprises using a ductile electrically conductive electrode made of carbon-polymer composite material. Prior to electric discharge machining, the electrode is made by heating uniformly a prescribed volume of said ductile electrode material, at a temperature close to the melting point temperature of the polymer matrix. The composite material is then molded into the desired electrode shape by pressing the soft material against a template, a mold model, a replicate of the workpiece or part of the workpiece. The formed electrode is then used to machine the desired shape and surface finish on the said workpiece using proper electric discharge machining techniques. When the dimensions and surface of the electrode are altered by wear, the same electrode can be rectified quickly and repetitively, by following the initial procedure of softening and pressing until the workpiece is complete.
Patent CA-2466118-A1 (CA)
Title: Modulation of lir function to treat rheumatoid arthritis
Inventor: ARM JONATHAN P
IPC: C07K16/28
Filed: 2002-11-12
Abstract: This invention relates to methods for treating rheumatoid arthritis (RA) by administering one or more agents that specifically target LIR-2, LIR-3 and LIR- 7. Results disclosed herein indicate that these three LIRs may participate in regulating the activation of leukocytes that infiltrate synovial tissue. Thus, inflammation in the joints of RA patients can be ameliorated by administering agents that modulate expression or function of LIR-2 and/or LIR-3 and/or LIR-7 to reduce or eliminate the activation of monocytes or macrophages present in inflamed joints, or to reduce their recruitment to the site of inflammation. This can be accomplished by modulating LIR-7, which transmits a stimulatory signal, and/or by modulating LIR-2 and/or LIR-3, which when triggered exert an inhibitory effect, or by concurrently modulating two or all three of these LIRs.
Patent CA-2469160-A1 (CA)
Inventor: SAITO TORU
IPC: B66C15/00
Filed: 2004-05-28
Abstract: A self propellered industrial machine includes a self propellered vehicle body (1); a transmission installed in the self propellered vehicle body; an operator presence detection switch (22) and a control unit (10). The operator presence detection switch is provided to generate an operator presence or absence signal relating to an operator on a seat arranged on the self propellered vehicle body. The control unit is provided to set the transmission to a neutral state in response to the operator absence signal.
Patent CA-2469815-A1 (CA)
Title: Methods for purifying protein
Inventor: BROOKS CLAYTON A III
IPC: C07K14/715
Filed: 2002-12-20
Abstract: A method is provided for separating a protein from one or more other protein s using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does. In some embodiments, a second protein affixed to a solid support has been used previously to purify the protein by affinity chromatography, and small amounts of the second protein are introduced in the sample during this process. The protein being purified can comprise at least one constant antibody immunoglobulin domain. The secon d protein can bind to proteins comprising such a domain.
Patent CA-2470446-A1 (CA)
Title: Plasma display device and control method therefor
Inventor: LACOSTE ANA
IPC: G09G3/28
Filed: 2002-12-23
Abstract: The plasma display has a chamber (17) retaining a gas, which is excited to emit visible light, in combination with a phosphorescent layer (18) that emits light when excited by ultraviolet light from the discharge. A uniformly distributed electric field (E) ignites the discharge, and a matrix of control elements (19) locally modulates the electric field to selectively illuminate screen points.
Patent CA-2470820-A1 (CA)
Title: Diagnostic sensing apparatus
Inventor: KWON SUNG-YUN
IPC: G01N33/483
Filed: 2002-12-13
Abstract: A sensing apparatus and methods for measuring or detecting an analyte presen t in a biological system are provided. The methods entail use of the sensing apparatus that contains a reporter system specific for the analyte of interest, where the reporter system is either affixed to a planar backing or attached to particles that are delivered to the superficial layers of the skin. The reporter system includes a reporting reagent that absorbs or emits a detectable radiation and is placed in communication with the analyte, or in communication with tissue or body fluids suspected of containing the analyte . The sensing apparatus is illuminated, and a radiation signal from the reporting reagent is measured or detected and then associated with the presence or quantity of analyte.
Patent CA-2470911-A1 (CA)
Title: Lancing devices and methods of using the same
Inventor: KURIGER REX J
IPC: A61B5/15
Filed: 2004-06-15
Abstract: A lancing device for drawing a body fluid sample from the skin that comprises a body portion, an endcap, a lancet and a vibration member. The endcap detachably connects to the body portion. The lancet is located within the body portion in a retracted position. The lancet is moveable between a retracted position and an extended position, and adapted to draw body fluid sample from the skin at a puncture site in an extended position. The vibration member extends through the endcap and is adapted to mechanically vibrate the skin adjacent to the puncture site. The lancet is adapted to draw the body fluid sample from the skin at a puncture site by extending through an opening formed in the endcap, the vibration member or the combination thereof. One example of a vibration member is a piezoelectric member.
Patent CA-2471416-A1 (CA)
Title: Low water uptake silicas
Inventor: VALERO REMI
IPC: A23L29/294
Filed: 2002-12-24
Abstract: The invention concerns a method for preparing low water uptake precipitated silicas, comprising successive steps which consist in: (a) producing an initial starter including a silicate, the silicate concentration in said starter, expressed in SiO¿2? equivalent, being less than 15 g/L; (b) bringing the medium pH to a value ranging between 7 and 8 by adding an acidifying agent, (c) in the resulting medium, simultaneously adding a silicate and an acidifying agent the respective amounts of silicate and acidifying agent added in time being specifically such that, during the entire addition (i) the reaction medium pH stays between 7 and 8, and (ii) the silicon concentration in the medium, expressed in SiO¿2 ?equivalent, stays below 35 g/L; (d) adding an acidifying agent in the medium resulting from step (c), so as to bring the medium to a pH ranging between 3 and 6.5; and (e) filtering the resulting aqueous silica dispersion, then drying the filter cake obtained at the end of the filtering step. The invention also concerns low water uptake silicas obtained by said method and their use, in particular for reinforcing silicones or polymer or elastomer matrices.
Patent CA-2472080-A1 (CA)
Title: Fibre inorganique vitreuse resistant aux temperatures elevees
Inventor: ZOITOS BRUCE K
IPC: C03C13/00
Filed: 2003-01-10
Abstract: La présente invention se rapporte à une fibre inorganique vitreuse à faible retrait, résistant aux températures élevées, caractérisée par une température d'utilisation pouvant atteindre au moins 1330· C. Cette fibre conserve son intégrité mécanique après exposition à la température d'utilisation et elle est non durable dans les fluides physiologiques. Le procédé de préparation de cette fibre consiste à former une matière fondue dont les constituants incluent plus de 71,25 % en poids de silice, 0 à environ 20 % en poids de magnésie et environ 5 à environ 28,55 % en poids de calcie, 0 à environ 5 % en poids de zircone et éventuellement un modificateur de viscosité en quantité suffisante pour permettre la fibérisation du produit ; et enfin à produire les fibres à partir de la matière fondue.
Patent CA-2472825-A1 (CA)
Title: Drill string rotation encoding
Inventor: JONES STEPHEN
IPC: E21B47/12
Filed: 2004-07-02
Abstract: A method for communicating with a downhole device is provided. The method includes predefining an encoding language including codes understandable to the device, the codes represented in the language as predefined value combinations of drill string rotation variables such as rotation rate or duration. The method further includes rotating a drill string at first and second rates and measuring the rotation rates downhole. The first measured rotation rate is processed downhole in combination with the second measured rotation rate to acquire a code in the language at the downhole device.  Embodiments of the invention are useful, for example, for transmitting commands from the surface to a downhole device such as a directional drilling tool. Exemplary embodiments of this invention advantageously provide for quick and accurate communication with a downhole device without substantially interrupting the drilling process.
Patent CA-2474590-A1 (CA)
Title: Treatment of male sexual dysfunction
Inventor: TANG KIM-WAH
IPC: A61K38/095
Filed: 2003-01-20
Abstract: A composition comprising a selective oxytocin antagonist for use in the treatment and/or prevention of a male ejaculatory disorder; which selective oxytocin antagonist is optionally admixed witha a pharmaceutically acceptabl e carrier, diluent or excipient.
Patent CA-2474782-A1 (CA)
Inventor: REITER YORAM
IPC: C12P21/02
Filed: 2003-02-11
Abstract: An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.
Patent CA-2475722-A1 (CA)
Inventor: SINGH ROMI BARAT
IPC: A61K31/40
Filed: 2003-02-14
Abstract: A pharmaceutical formulation having improved bioavailability and bioequivalence includes particles of amorphous and/or crystalline atorvastat in that have a particle size (d90) less than 150 m and a mean particle size (d5 0) of the atorvastatin particles that is between approximately 5 and 50 m. The atorvastatin can be one or more of atorvastatin calcium, atorvastatin magnesium, atorvastatin aluminum, atorvastatin iron, and atorvastatin zinc. The formulations of atorvastatin can be stabilized by mixing atorvastatin wi th an alkali metal salt additive at between approximately 1.2% and less than 5% w/w of the formulation. The alkali metal salt additive may be one or more of sodium carbonate, sodium bicarbonate, sodium hydroxide, sodium silicate, disodium hydrogen orthophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, sodium aluminate, calcium carbonate, calcium hydroxide, magnesium carbonate, magnesium hydroxide, magnesium silicate, magnesium aluminate, and aluminum magnesium hydroxide. The atorvastatin formulations can be used to treat medical conditions, including primary hypercholesterolemia, dysbetalipoproteinemia, and homozygous familia l hypercholesterolemia.
Patent CA-2476188-A1 (CA)
Title: Molecule vibrator
Inventor: MIZUNO TAKAJI
IPC: C12M3/00
Filed: 2003-02-12
Abstract: A voltage generator circuit (20) for generating a voltage is provided. A  voltage application circuit (30) which is composed of electrodes (11, 12) for generating, on receiving the voltage generated by the voltage generator circuit (20), an instantaneous high electric field at a predetermined portion where a biological tissue or a cell is targeted and has a high impedance to excite a free resonance circuit including the target is provided. The relative positions of the target and the electrodes (11, 12) are variable.
Patent CA-2476920-A1 (CA)
Inventor: SCHOONMAKER DAVID A
IPC: H01M8/04
Filed: 2003-02-06
Abstract: The present invention provides an aqueous-based electrolyte slurry for molten carbonate fuel cells. The invention provides means to eliminate the potential for the preferential transport of potassium carbonate and subsequent irreversible alteration of the 62/38 molar ratio of the eutectic mixture of the lithium potassium carbonate electrolyte.
Patent CA-2477205-A1 (CA)
Inventor: KAWANISHI MASASHI
IPC: C07C275/42
Filed: 2003-02-18
Abstract: La présente invention concerne un composé représenté par la formule (1) suivante : (dans laquelle R1 représente alkyke C1-12, phényle, 1-naphthyle, etc. ; R2 représente alkyle C2-12 ; (R3)b représente de zéro à quatre substituants, par ex., halogéno ; R4 représente alkyle inférieur ; R5 représente hydrogène ou alkyle inférieur ; n est un entier de 2 à 4 ; et X représente  NH- ou  O-), ou un sel dudit composé.  Le composé ou sel de l'invention est d'une grande efficacité pour réduire le niveau de sucre sanguin, de lipides et de cholestérol total et il est utilisé comme ingrédient actif dans des médicaments destinés à la prévention et/ou au traitement de maladies telles que le diabète et l'hyperlipidémie.
Patent CA-2477688-A1 (CA)
Inventor: NOLAN TIMOTHY D
IPC: C12Q1/68
Filed: 2003-02-27
Abstract: L'invention concerne des gènes prédictifs d'une toxicité des reins lesquels peuvent être utilisés pour prédire une toxicité des reins en réponse à un ou à plusieurs agents.
Patent CA-2478448-A1 (CA)
Title: Transobturator surgical articles and methods
Inventor: WATSCHKE BRIAN P
IPC: A61F2/00
Filed: 2003-03-04
Abstract: Surgical articles, implants and components suitable for a transobturator surgical procedure are described.
Patent CA-2479112-A1 (CA)
Inventor: MURELLO JOHANNES
IPC: F41A3/46
Filed: 2003-08-27
Abstract: The invention relates to a self-loading handheld firearm comprising a rigid barrel (1) which is provided with a cartridge chamber (3), a lockable closin g head (11) which is locked in relation to the barrel (1) and a closing carrie r (13) which can be displaced in relation to the closing head whereon a closin g spring (9) is supported. An additional, progressively powerful spring arrangement (17, 41) is arranged between the closing carrier (13) and the closing head (11), via which the (heavy) closing carrier (13) is supported when the closing head (11) is locked.
Patent CA-2479260-A1 (CA)
Title: Use of sulfoalkyl ether cyclodextrin as a preservative
Inventor: PIPKIN JAMES D
IPC: A61K31/05
Filed: 2003-03-19
Abstract: A method of preserving formulations is provided. The method includes the step of including a derivatized cyclodextrin in a formulation capable of sustaining microbial growth. One embodiment of the formulation employs a sulfoalkyl ether cyclodextrin as a preservative and optionally as a solubilizing and complexing agent. A suitable cyclodextrin is the CAPTISOL" brand cyclodextrin (sulfobutyl ether R-cyclodextrin). Whether or not the formulation includes a conventional preservative, the formulation will remain preserved for at least a minimum predetermined period. Specific embodiments of the invention include a carrier, a derivatized cyclodextrin and optionally one or more active agents, one or more water activity-reducing agents, and/or one or more complexation-enhancing agents. The derivatized cyclodextrin reduces the water activity of the formulation. A liquid formulation can be lyophilized or otherwise dried to yield a solid formulation that is optionally reconstitutable.
Patent CA-2480016-A1 (CA)
Title: Histone deacetylase: novel molecular target of neurotoxicity
Inventor: SCHWEIGHOFFER FABIEN
IPC: C12Q1/68
Filed: 2003-03-25
Abstract: The invention concerns the field of biology, genetics and medicine. In particular, it concerns novel methods for detecting, characterizing and/or treating neurodegenerative pathologies, in particular amyotrophic lateral sclerosis. The invention also concerns methods for identifying or screening compounds active in said pathologies. The invention further concerns compounds, genes, cells, plasmids or compositions useful for implementing said methods. In particular, the invention concerns the role of histones deacetylases, and particularly histone deacetylase 2, in said pathologies and its use as therapeutic, diagnostic or experimental target.
Patent CA-2480372-A1 (CA)
Inventor: PODOLSKY DANIEL K
IPC: A61K38/00
Filed: 2003-03-26
Abstract: This invention features methods and compositions of combination therapy suitable for treating and preventing epithelial lesions. Lesions are treated or prevented by combining trefoil peptide therapy with another medically useful therapeutic agent. Suitable therapeutics for combination therapy with a trefoil peptide included chemotherapeutics, particularly orally administered chemotherapeutics, analgesic, antibiotic, and anti-inflammatory agents. Useful trefoil peptides include the naturally occurring trefoil peptides intestinal trefoil factor, spasmolytic polypeptide (SP), and pS2, as well as non-naturally occurring peptides that contain a trefoil domain.
Patent CA-2483651-A1 (CA)
Inventor: MA SHEAU-HWA
IPC: C09K23/52
Filed: 2003-06-03
Abstract: La présente invention concerne un dispersant polymère destiné à des pigments à base d'un copolymère greffé qui contient un nouveau type de groupe fonctionnel urée en tant que groupe de fixation des pigments. Les groupes urée sont attachés au copolymère greffé par un procédé pratique qui implique la réaction de groupes fonctionnels hydroxyle construits dans le copolymère greffé avec un diisocyanate qui est coiffé à une extrémité par de l'ammoniaque ou une amine primaire ou secondaire. La réaction est pratique et propre. La réticulation ou la gélification substantielle du polymère peut être facilement évitée par la sélection judicieuse des ingrédients et des conditions de traitement appropriés. Ces matières sont efficaces pour disperser et stabiliser une grande diversité de pigments dans des systèmes à base de solvant et sont particulièrement utiles dans la formation de dispersions de pigments qui sont utilisées dans une diversité de compositions de revêtement à base de solvant pour des automobiles et des camions, où elles assurent une meilleure efficacité de l'utilisation des pigments, une viscosité réduite de la peinture et un rejet moins important de solvant organique volatil.
Patent CA-2483787-A1 (CA)
Inventor: WOS JOHN AUGUST
IPC: A61P21/02
Filed: 2003-04-16
Abstract: La présente invention se rapporte à des composés qui comportent un anneau pipéridine 4-substitué lié à un anneau hydrocarbyle substitué ou non substitué. Ces composés, notamment toutes les formes énantiomères et diastéromères et les sels pharmaceutiquement acceptables de ces formes, présentent la formule (I), dans laquelle R est de préférence aryle substitué, W est une unité latérale ayant la formule: -L-Q, L étant une unité de liaison, Q étant de préférence une unité hydrocarbyle cyclique; W?1¿ est de préférence une unité carbocyclique et W?2¿ est une unité comprenant un hétéroatome.