Patent SG-11201903232U-A (SG)
Title: Process for the preparation of (3s,4s)-tetrahydrofuran-3-yl 4-isopropyl-6,7-dihydro-3h-imidazo[4,5-c]pyridine-5(4h)-carboxylate
Inventor: HORGAN ANNE
IPC: C07D471/04
Filed: 2017-10-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111H1111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/078363 Al 03 May 2018 (03.05.2018) WIP0 I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C07D 471/04 (2006.01) C07C 309/04 (2006.01) kind of regional protection available): ARIPO (BW, GH, C07C 5 9 / 5 0 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (21) International Application Number: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, PCT/GB2017/053218 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (22) International Filing Date: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 25 October 2017 (25.10.2017) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: English (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 1618029.1 25 October 2016 (25.10.2016) GB (71) Applicant: PROXIMAGEN LIMITED [GB/GB]; Miner- va Building 250, Babraham Research Campus, Cambridge, Cambridgeshire CB22 3AT (GB). (72) Inventors: HORGAN, Anne; c/o Proximagen Limited, Minerva Building 250, Babraham Research Campus, Cam- bridge Cambridgeshire CB22 3AT (GB). HAGLUND, Olof; c/o Proximagen Limited, Minerva Building 250, Babraham Research Campus, Cambridge Cambridgeshire CB22 3AT (GB). PATIENT, Lee; c/o Proximagen Lim- ited, Minerva Building 250, Babraham Research Campus, Cambridge Cambridgeshire CB22 3AT (GB). SAVORY, Edward; c/o Proximagen Limited, Minerva Building 250, Babraham Research Campus, Cambridge Cambridgeshire CB22 3AT (GB). HIGGINBOTTOM, Michael; c/o Prox- imagen Limited, Minerva Building 250, Babraham Re- search Campus, Cambridge Cambridgeshire CB22 3AT (GB). ASHWOOD, Michael; c/o Proximagen Limited, Minerva Building 250, Babraham Research Campus, Cam- bridge Cambridgeshire CB22 3AT (GB). Agent: GILL JENNINGS & EVERY LLP; The (74) Broadgate Tower, 20 Primrose Street, London EC2A 2ES (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) 1-1 M SO M GC IN ......_ © (54) Title: PROCESS FOR THE PREPARATION OF (3S,4S)-TETRAHYDROFURAN-3-YL 4-ISOPROPYL-6,7-DIHYDRO-3H- GO\" IMIDAZO[4,5-C]PYRIDINE-5(4H)-CARBOXYLATE 1-1 0 (57) : The invention relates to an improved process for the synthesis of (3S,4S)-tetrahydrofuran-3-y14-isopropy1-6,7-dihydro-3 \" H-imidazo[4,5-c]pyridine-5(4H)-carboxylate, and pharmaceutically acceptable salts thereof, such as the methanesulphonic acid salt.