Patent SG-11201906500X-A (SG)
Title: System and method with reflective fiducials
Inventor: VIECELI JOHN
IPC: G01N21/64
Filed: 2018-01-31
Abstract: Title: SYSTEM AND METHOD WITH REFLECTIVE FIDUCIALS (57) : Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve process- 22 ing, that provide encoding of useful information, and so forth. Examples of the fiducials NUCLEOTIDE L 12 DEUVERY S J i may include features and materials that are provided on or in the support of the array SYSTEM ' and that return at least a portion of incident light by reflection. The fiducials may form gratings or other encoding configurations that assist in image processing, alignment, or other aspects of processing of the array. DEBLOCK STATION H ! 28 12 X14 16 10 W O 20 18/ 1445 8 2 Al FIG. 1 24 H- FLUSH STATION DOWNSTREAM / 18 PROCESSING /s\" STORAGE SYSTEM IMAGING SYSTEM DATA ANALYSIS SYSTEM (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT onion °nolo Homo mil Hill mom oimIE (10) International Publication Number WO 2018/144582 Al (51) International Patent Classification: GO1N 21/64 (2006.01) (21) International Application Number: PCT/US2018/016205 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701691.6 01 February 2017 (01.02.2017) GB (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, CA 92122 (US). (72) Inventors: VIECELI, John, S.; 1498 Flair Encinitas Drive, Encinitas, CA 92024 (US). NEMIROSKI, Alex; 5205 Fiore Ten, Apt. B410, San Diego, CA 92122 (US). BELITZ, Paul; 5200 Illumina Way, San Diego, CA 92122 (US). LANGLOIS, Robert; 5200 Illumina Way, San Diego, CA 92122 (US). BOWEN, M., Shane; 5200 Illu- mina Way, San Diego, CA 92122 (US). CHAN, Danny, Yuan; 5200 Illumina Way, San Diego, CA 92122 (US). VENKATESAN, Bala Murali K.; 499 Illinois Street, Suite 210, San Francisco, CA 94158 (US). HAN, Hui; 5200 Illu- mina Way, San Diego, CA 92122 (US). SAMIEE, Kevan; 5200 Illumina Way, San Diego, CA 92122 (US). TANNER, Stephen; 5200 Illumina Way, San Diego, CA 92122 (US). (74) Agent: DIERKER, Julia, Church et al.; Dierker & Ka- vanaugh, P.C., 3331 W. Big Beaver Road, Suite 109, Troy, MI 48084 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] WO 2018/144582 Al MIDEDIM01101 OlD IIMEN3010M01111111111111111111111111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3))