Patent IL-139264-A (IL)
Title: Substituted sulphonyl cyanamides, method for producing same and their use as medicaments
IPC: A61K31/415
Filed: 1999-04-30
Abstract: A compound of the formula in which the symbols have the following meanings: X is equal to 1967 ז' באב התשס" ד - July 25, 2004 R(1) is hydrogen, alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms; or -CaH2a-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from the group F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(19)R(20); R(19) and R(20) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; a is zero, 1 or 2; or R(1) is -CbH2b- heteroaryl having 1,2,3,4,5,6,7,8 or 9 carbon atoms where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(21)R(22); R(21) and R(22) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; b is zero, 1 or 2; or R(1) is -CcH2c-cycloalkyl having 3,4,5,6 or 7 carbon atoms; c is zero, 1 or 2; R(2) and R(3) independently of one another are hydrogen, F, Cl, Br, I, CF3, -CN, =NO2, CH2OR(23), CO-R(24) or O-R(25); R(23) is hydrogen or alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms; R(24) is hydrogen, alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms, OR(26) or phenyl; where phenyl is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from the series consisting 1968 ז' באב התשס" ד - July 25, 2004 of 1-3 substituents from the group consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(27)R(28); R(27) and R(28) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; R(26) is hydrogen or alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms; R(25) is hydrogen, alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms, or phenyl; where phenyl is unsubstituted or substituted by 1,2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(29)R(30); R(29) and R(30) independently of one another are H or alkyl having 1,2,3 or 4 carbon atoms; or R(25) is heteroaryl having 1,2,3,4,5,6,7,8 or 9 carbon atoms, which is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(31)R(32); R(31) and R(32) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; or R(2) and R(3) independently of one another are alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms, cycloalkyl having 3,4,5,6 or 7 carbon atoms; or -CdH2d-phenyl, where the phenyl moiety is unsubstituted or substituted by 1,2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(33)R(34); R(33) and R(34) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; d is zero, 1 or 2; or R(2) and R(3) independently of one another are -CeH2e-heteroaryl having 1,2,3,4,5,6,7,8 or 9 carbon atoms, where the heteroaryl moiety is unsubstituted or substituted by 1, 2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR(35)R(36); R(35) and R(36) independently of one another are H or alkyl having 1, 2, 3 or 4 carbon atoms; e is zero, 1 or 2; or R(2) and R(3) independently of one another are -SOf-R(37); R(37) is alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms, cycloalkyl having 3,4,5,6 or 7 carbon atoms, or -CgH2g-phenyl, where the phenyl moiety is unsubstituted or substituted by 1 , 2 or 3 identical or different radicals from the series consisting of F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR(38)R(39); R(38) and R(39) independently of one another are H or alkyl having 1,2,3 or 4 carbon atoms; f iz zero, 1 or 2; g is zero, 1 or 2; R(4) is hydrogen, alkyl having 1,2,3,4,5,6,7 or 8 carbon atoms, 1-naphthyl, 2-naphthyl, -CiH2i-cycloalkyl having 3,4,5,6 or 7 carbon atoms or -CiH2i-phenyl, where the phenyl moiety is unsubstituted or substituted by 1, 2 or 3 identical or