Patent SG-11201807980Q-A (SG)
Title: Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer
Inventor: BALOG James
IPC: C07D317/66
Filed: 2016-04-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 011111011101111011011131101111111011 III 11 International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2016/161286 Al 6 October 2016 (06.10.2016) WIPO I PCT (51) International Patent Classification: A.; c/o Bristol-Myers Squibb Company, Route 206 and C07D 309/14 (2006.01) CO7D 239/42 (2006.01) Province Line Road, Princeton, NJ 08543 (US). SHAN, CO7C 275/42 (2006.01) CO7D 261/14 (2006.01) Weifang; c/o Bristol-Myers Squibb Company, Route 206 CO7D 317/66 (2006.01) CO7D 487/04 (2006.01) and Province Line Road, Princeton, NJ 08543 (US). WIL- CO7D 401/12 (2006.01) A61K 31/17 (2006.01) LIAMS, David, K.; c/o Bristol-Myers Squibb Company, CO7D 405/12 (2006.01) A61P 35/00 (2006.01) Route 206 and Province Line Road, Princeton, NJ 08543 (US). NARA, Susheel, Jethanand; c/o Syngene Interna- (21) International Application Number: PCT/US2016/025554 tional Limited, Biocon Special Economic Zone, Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV (22) International Filing Date: Phase, Jigani Link Road, Bommasandra Bangalore, 1 April 2016 (01.04.2016) Karnataka 560 099 (IN). ROY, Saumya; c/o Syngene In- ternational Limited, Biocon Special Economic Zone, (25) Filing Language: English Biocon Park, Plot No. 2 & 3, Bommasandra Industrial (26) Publication Language: English Area IV Phase, Jigani Link Road, Bommasandra Ban- galore, Karnataka 560 099 (IN). (30) Priority Data: 62/142,589 3 April 2015 (03.04.2015) US (74) Agents: GIBBONS, Maureen, S. et al.; Bristol-Myers Squibb Company, Route 206 and Province Line Road, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543 (US). [US/US]; Route 206 and Province Line Road, Princeton, NJ 08543 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (72) Inventors: BALOG, James, Aaron; c/o Bristol-Myers AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, — Squibb Company, Route 206 and Province Line Road, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, _ Princeton, NJ 08543 (US). GUO, Weiwei; c/o Bristol-My- DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, ers Squibb Company, Route 206 and Province Line Road, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, = Princeton, NJ 08543 (US). HUANG, Audris; c/o Bristol- KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, Myers Squibb Company, Route 206 and Province Line MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Road, Princeton, NJ 08543 (US). MARKWALDER, Jay, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = [Continued on next page] — (54) Title: INHIBITORS OF INDOLEAMINE = = = R 2 R3 - = = = \IC _ ,-, . 4 GC ei ,-1 1-1 -.... 1-1 0 ei -....,.. 1 \ x 'i'. --- 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER (57) : There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), R6 pharmaceutical compositions containing said com- pounds and methods of treating proliferative dis- orders, such as cancer, viral infections and/or in- N H i mm n n v a e tion. t o ry disorders utilizing the compounds of the R5 I R 4 (I) O WO 2016/161286 Al MIDEDIMOMOIDEIRME01301110110111EIERVOIMIE SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) Designated States (unless otherwise indicated, for every Declarations under Rule 4.17: kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, of inventorship (Rule 4.17(iv)) TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Published: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, with international search report 21(3)) (Art.