Patent SG-11201908329Q-A (SG)
Title: Systems and methods for printing a fiber structure
Inventor: BEYER SIMON
IPC: B29C64/106
Filed: 2018-03-15
Abstract: CrosslinkerMaterial Valve ON - Printhead 1. 4 BodY , Material 2 alve 1FF (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT oimiolollm °nolo Oil woo minio (10) International Publication Number WO 2018/165761 Al (51) International Patent Classification: B29C 64/209 (2017.01) B29C 64/343 (2017.01) B29C 64/106 (2017.01) B33Y 10/00 (2015.01) B29C 64/336 (2017.01) B33Y 30/00 (2015.01) (21) International Application Number: PCT/CA2018/050315 (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,564 15 March 2017 (15.03.2017) US (71) Applicant: ASPECT BIOSYSTEMS LTD. [CA/CA]; 1781 West 75th Avenue, Vancouver, British Columbia V6P 6P2 (CA). (72) Inventors: BEYER, Simon; 301-7051 Blundell Road, Richmond, British Columbia V6Y 1J5 (CA). MOHAMED, Tamer; 6580 Riverdale Drive, Richmond, British Colum- bia V7C 2G1 (CA). (74) Agent: BEGLEITER RODIN, Leah et al.; Blake, Cassels & Graydon LLP, 199 Bay Street, Suite 4000, Commerce Court West, Toronto, Ontario M5L 1A9 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: SYSTEMS AND METHODS FOR PRINTING A FIBER STRUCTURE (57) : Aspects of the invention include systems and meth- FIG. 3 ods for producing fiber structures, and for producing three-dimensional (3D) biological structures from digital files. In some embodiments, the printed fibers comprise living cells. Aspects of the invention further in- clude a print head for producing the fiber structure, the print head com- prising: a dispensing channel comprising a distal and proximal end; a dispensing orifice located at the distal end of the dispensing channel; one or more material channels converging with the dispensing chan- nel at its proximal end; a buffer solution channel converging with the one or more material channels at the proximal end of the dispensing channel; and a sheath solution channel converging with the dispensing channel at a position located between the proximal and distal ends of the dispensing channel. The print head is configured to displace one or more input materials with a buffer solution at the proximal end of the dispensing channel to terminate the fiber structure with a clean tail end. W O 20 18/ 1657 6 1 Al short channel filled with lu der nrevents 005SalKer interactim with bioink inputs Buffer displaces bioink I while maintaining constant How of fiber termination printhead exit channel [Continued on next page] WO 2018/165761 Al MIDEDIM000101011EFIE011111111H100111111111101111111011110111111 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3))