baber/WOPTO huggingface dataset:
Patent ES-2224332-T3 (ES)
Title: Procedimiento y dispositivo para quitar una capa superficial.
Inventor: MULLER GERHARD PROF DR-ING
IPC: B23K26/146
Filed: 1998-11-06
Granted: 2005-03-01
Abstract: PROCEDIMIETO PARA ELIMINACION DE UNA CAPA (1.7) SUPERFICIAL DE UN SUBSTRATO (1.6) BAJO INCIDENCIA DE RADIACION LASER (1.1), DONDE LA SUPERFICIE ES EXPLORADA SECUENCIALMENTE CON RADIACION LASER CONCENTRADA SOBRE UN FOCO (1.5). ANTES DE LA RADIACION DE UN ELEMENTO SUPERFICIAL, PREVIAMENTE DETERMINADO SOBRE LA CAPA SUPERFICIAL, SE APLICA AL MENOS UNA PELICULA DELGADA (1.4A) O UNA ALFOMBRA DE GOTITAS DE UN FLUIDO (1.4'') QUE RECUBRE AL MENOS EL ELEMENTO SUPERFICIAL Y LA RADIACION LASER SE INCIDE SOBRE EL ELEMENTO SUPERFICIAL DURANTE UN INTERVALO DE TRATAMIENTO CORTO, ESPECIALMENTE MENOR DE 10 MS. A TRAVES DE ELECCION ADECUADA DE LOS PARAMETROS DE PROCESO SE DETERMINA LA DENSIDAD DE POTENCIA DE REDACCION LASER, LA DURACION DE INTERVALO DE TRATAMIENTO, EL ESPESOR DE LA PELICULA DE FLUIDO, LA ADHESION DEL FLUIDO EN LA SUPERFICIE, EL COMPORTAMIENTO DE ABSORCION DEL FLUIDO PARA LAS LONGITUDES DE ONDA EFECTIVA DE RADIACION LASER Y EL COMPORTAMIENTO DE ABSORCION DE AMORTIGUACION DEL FLUIDO DE UNA EVAPORACION DE TIPO DE EXPLOSION DE PELICULA DE FLUIDO BAJO ARRANCADO DE LA CAPA SUPERFICIAL Y UNA EVAPORACION DE LOS RESIDUOS (1.7A) AUN ADHERIDOS DE LA CAPA SUPERFICIAL.
Patent ES-2190809-T3 (ES)
Inventor: COLLIS ALAN JOHN
IPC: A61P15/00
Filed: 1998-04-16
Granted: 2003-08-16
Abstract: Compounds of formula I, <CHEM>  wherein   R<1> represents C1-4 alkoxy optionally substituted by one or more fluorine atoms, R<2> represents an aryl group or a heteroaryl group, optionally substituted by C1-4 alkyl or SO2NH2; R<3> represents a 4-, 5-, 6-, or 7-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring system as a whole being optionally substituted,   X represents CH or N; and   L is absent, or represents a cyclic group of formula Ia, <CHEM>     or represents a chain of formula Ib, <CHEM> and pharmaceutically acceptable salts thereof, are useful in the treatment of a variety of disorders including benign prostatic hyperplasia.
Patent ES-2194285-T3 (ES)
Title: Procedimiento y molde destinados al revestimiento de una pieza plastica con una hoja decorativa cortada y seguidamente liberada.
Inventor: BAUDOUIN IVAN
IPC: B29C43/40
Filed: 1998-07-17
Granted: 2003-11-16
Abstract: LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE REVESTIMIENTO POR AL MENOS UNA HOJA DE ADORNO NO RIGIDA DE ESENCIALMENTE UNA CARA DE ASPECTO DE UNA PIEZA DE SOPORTE DE MATERIAL(ES) PLASTICO(S), UN MOLDE PARA REALIZAR ESTE REVESTIMIENTO Y UNA PIEZA. SEGUN LA INVENCION, EL PROCEDIMIENTO COMPRENDE LAS SIGUIENTES ETAPAS: - INTRODUCIR LA HOJA EN LA CAVIDAD DE MOLDEO, - CERRAR AL MENOS PARCIALMENTE EL MOLDE POR ACERCAMIENTO DE SUS DOS PARTES, - INTRODUCIR MATERIAL PLASTICO (19 EN LA CAVIDAD DE MOLDEO, - RECORTAR AL MENOS UNA ABERTURA (2E) EN LA HOJA, - PROVOCAR UN DESPLAZAMIENTO RELATIVO DE LOS ELEMENTOS DE CORTE, PARA INDUCIR UN POSICIONAMIENTO DE LA ABERTURA SEPARADA DE UNO DE ESTOS ELEMENTOS, - REPARTIR EL MATERIAL EN LA CAVIDAD DE MOLDEO HACIENDOLO PASAR A TRAVES DE LA ABERTURA, - ENFRIAR LA PIEZA, - ABRIR EL MOLDE Y EYECTAR LA PIEZA ACABADA. ESTA SOLUCION MEJORA LA COHESION ENTRE LAS PARTES RECUBIERTAS Y NO RECUBIERTA DE LA PIEZA ACABADA.
Patent ES-2320053-T3 (ES)
Inventor: HACKETT JOHN R JR
IPC: C07K14/16
Filed: 1998-08-17
Granted: 2009-05-18
Abstract: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
Patent ES-2218881-T3 (ES)
Inventor: BIEDERMANN ELFI
IPC: C07D401/14
Filed: 1998-12-16
Granted: 2004-11-16
Abstract: The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group according to general formula (I), wherein the residue E is a cyclic imide, methods for the production of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors, inhibition of abnormal cell growth and control of immune reactions, for example autoimmune diseases.
Patent ES-2179573-T3 (ES)
Title: Dispositivo para la preparacion ininterrumpida de masas de elaboracionque contienen manteca de cacao u otra grasa similar.
Inventor: HEYDE HANS
IPC: A23G1/18
Filed: 1999-05-04
Granted: 2003-01-16
Abstract: UN DISPOSITIVO PARA LA PREPARACION CONTINUA DE MASAS QUE CONTENGAN MANTECA DE CACAO U OTRAS GRASAS SIMILARES, EN PARTICULAR MASA DE CHOCOLATE, COMPRENDE UNA COLUMNA DE ACONDICIONAMIENTO DE TEMPERATURA (1) QUE TIENE VARIAS CAMARAS (17) SUPERPUESTAS FORMANDO UN CILINDRO. CADA CAMARA (17) ESTA CONECTADA A UN CIRCUITO PARA UN FLUIDO DE ACONDICIONAMIENTO DE TEMPERATURA. ENTRE CADA DOS CAMARAS (17) CONTIGUAS ESTA PREVISTA UNA CAMARA DE ACONDICIONAMIENTO DE TEMPERATURA ESENCIALMENTE LIMITADA POR LAS SUPERFICIES DE ACONDICIONAMIENTO DE TEMPERATURA (18) DE LAS DOS CAMARAS (17) Y ATRAVESADA POR LA MASA, DONDE ESTA SITUADA UNA HERRAMIENTA (6) UNIDA A UN ARBOL DE ACCIONAMIENTO (3). DOS CAMARAS DE ACONDICIONAMIENTO DE TEMPERATURA (7) CONTIGUAS ESTAN UNIDAS ENTRE SI A TRAVES DE UN PASO DE MASA (29), PENETRANDO EN EL PASO UN SENSOR DE TEMPERATURA (27). EL PASO DE MASA (26) ESTA SITUADO ENTRE DOS CAMARAS DE ACONDICIONAMIENTO DE TEMPERATURA CONTIGUAS (7) RADIALMENTE EN EL INTERIOR Y FORMA EL INTERSTICIO ANULAR QUE RODEA EL ARBOL DE ACCIONAMIENTO (3).
Patent ES-2205752-T3 (ES)
Inventor: CALDORO NICOLA
IPC: B29C33/04
Filed: 1999-05-24
Granted: 2004-05-01
Abstract: A mould (30) is described for moulding an elastomeric glazing profile (15) in situ on a single major face (12) of a sheet (11) of glazing material, e.g. a glass sheet. The mould comprises a first mould segment (31) and at least one further mould segment (32) which are relatively movable, into intimate contact, so that they define, together with the sheet, a mould cavity (50) for moulding the profile on single major face. The profile has a show face (23), (i.e. one which is visible in use), and the portion (51) of the mould cavity that moulds the show face is entirely formed by a single mould segment to avoid mould lines on the show face. Also described are a corresponding moulding method and the glazing product (10) thereby obtained, which may be used as a vehicle window. <IMAGE>
Patent ES-2185303-T3 (ES)
Inventor: CHAPPERT CLAUDE
IPC: H01J37/317
Filed: 1999-01-12
Granted: 2003-04-16
Abstract: Process for writing on a material, in which said material is irradiated by means of a beam of light ions, such as for example He<SUP>+</SUP> ions, said beam of light ions having an energy of the order of or less than a hundred keV, wherein this material comprises a plurality of superposed thin-layers, at least one of said thin layers being magnetic and in that one or more regions having sizes of the order of 1 micrometer or less are irradiated, the irradiation dose being controlled so as to be a few 10<SUP>16 </SUP>ions/cm<SUP>2 </SUP>or less, the irradiation modifying the composition of atomic planes in the material at one or more interfaces between two layers of the latter.
Patent ES-2272050-T3 (ES)
Title: Nueva familia de canales de potasio de mamiferos mecanosensibles activados por los acidos grasos poliinsaturados y su utilizacion especialmente para el cribado de farmacos.
Inventor: HONORE ERIC
IPC: C12N15/00
Filed: 1999-02-23
Granted: 2007-04-16
Abstract: Proteína purificada que forma un canal de potasio mecanosensible activado por los ácidos grasos poliinsaturados, particularmente el ácido araquidónico, y por el riluzol, cuya secuencia de aminoácidos se representa en la lista de secuencias adjuntas con el número SEQ ID n.º 1.
Patent ES-2253874-T3 (ES)
Title: Dispositivo limpiaparabrisas.
Inventor: KLUG HANS-GEORG
IPC: B60S1/08
Filed: 1999-01-08
Granted: 2006-06-01
Abstract: La invención se refiere a un sistema limpiaparabrisas diseñado especialmente para la limpieza del parabrisas de un vehículo de motor y que comprende al menos una escobilla que se puede desplazar entre dos posiciones finales y está accionado por un motor de accionamiento eléctrico. Dicho limpiaparabrisas comprende también una unidad de control que procesa como valores de entrada las señales de salida de un sensor de lluvia y las señales de conmutación de un medio de conmutación controlado manualmente, y que controla como valores de salida un suministro de voltaje del motor de accionamiento eléctrico y la velocidad de la escobilla. De acuerdo con la invención, la(s) escobilla(s) del parabrisas (8) se pueden operar con periodos de reposo variables en un modo de limpieza intermitente y que varía la velocidad de las escobillas sobre la base de la cantidad de lluvia detectada por el sensor de lluvia (12).
Patent ES-2283108-T3 (ES)
Inventor: ASSELL ROBERT L
IPC: A61F2/00
Filed: 1999-03-16
Granted: 2007-10-16
Abstract: A capsule-shaped prosthetic spinal disc nucleus for implantation into a human intradiscal space, made of a substantially inelastic constraining jacket surrounding an amorphous polymer core. The constraining jacket has a generally fixed maximum volume and defines a height. The amorphous polymer core fills an initial volume of the constraining jacket and develops an internal pressure. In response to the internal pressure, the constraining jacket transitions toward the maximum volume, increasing substantially in height.
Patent ES-2234264-T3 (ES)
Inventor: SEGAL SCOTT
IPC: F16L37/248
Filed: 1999-06-08
Granted: 2005-06-16
Abstract: A medical connector adapted for placement between a catheter and a medical infusion or injection source includes a pair of interlocking half medical connector portions, one side of which attaches to the infusion source and the other side of which is coupled to the catheter connected to the patient and a locking mechanism for locking a medical connector portion to a medical fitting. The connection to the catheter and the infusion source can be via standard medical luer taper fittings, with or without specially designed locking mechanisms that prevent inadvertent disconnection. The medical connector itself is uniquely shaped and includes a raised surface feature and a recessed surface feature formed on the medical connector portions.
Patent ES-2192392-T3 (ES)
Inventor: NINANE LEON
IPC: C01F11/46
Filed: 1999-08-10
Granted: 2003-10-01
Abstract: Process for the production of sodium chloride crystals from a sodium chloride brine contaminated by potassium chloride and sulphate ions, according to which a calcium compound (32) is added to the brine (48) to crystallize glauberite (35), which is isolated, the resulting aqueous solution (36) is subjected to evaporation to crystallize sodium chloride (40), which is collected, and the aqueous mother liquor (41) from the crystallization of the sodium chloride is subjected to cooling (42) to crystallize glaserite (45).
Patent ES-2244217-T3 (ES)
Inventor: PERKINS RODNEY
IPC: H04L9/00
Filed: 1999-09-21
Granted: 2005-12-01
Abstract: A data transfer system comprises a sender, receiver and a key facility. The sender encrypts data and splits it into parts. One part is further encrypted for a key facility. The parts are sent to the receiver. The receiver requests decryption of the part encrypted for the key facility and the receiver is then able to decrypt the complete data.
Patent ES-2195634-T3 (ES)
Inventor: LEHTINEN OTTO
IPC: H04W36/36
Filed: 1999-11-08
Granted: 2003-12-01
Abstract: The timing of frames associated with a certain first communication connection (301) and allocated for measurement and reception of signalling (302, 303) external to said first communication connection is defined in a cellular radio system. Transmission associated with communication connections is essentially continuous and consists of consecutive frames. Measurement and reception of signalling external to a communication connection necessitates an interruption in the otherwise continuous transmission associated with the communication connection. According to the invention, there is established (701) knowledge that indicates at least one future occurrence of signalling external to the first communication connection. Further there is identified (702), on the basis of said established knowledge, a future frame (305, 307, 308, 310) associated with the first communication connection that will coincide in time (304, 306, 309) with said future occurrence of signalling external to the first communication connection. The identified future frame will be defined as a frame allocated for measurement and reception of signalling external to the first communication connection.
Patent ES-2212858-T3 (ES)
Title: Metodo de instalacion mejorado para capas base de alfombras y moquetas.
Inventor: MURPHY PETER MICHAEL
IPC: A47G27/04
Filed: 1999-11-12
Granted: 2004-08-01
Abstract: Procedimiento que es para instalar una capa base hermética al agua para alfombras o moquetas y comprende los pasos de: a) colocar un almohadillado sobre un pavimento, y fijar opcionalmente dicho almohadillado al pavimento; b) colocar una capa base sobre dicho almohadillado; y c) sujetar mecánicamente con sujetadores la capa base al pavimento a través de dicho almohadillado; comprendiendo dicha capa base un género o una película hermético(a) al agua, siendo dicha hermeticidad medida vertiendo 20 ml de agua sobre una muestra de ensayo de alfombra o moqueta en un sitio situado encima de un sujetador de la capa base desde una altura de 6 cm, como resultado de lo cual no hay mancha de humedad después de 30 minutos, o bien hay una mancha de humedad que tiene un diámetro de 2, 54 cm como máximo en una toalla de papel colocada entre la capa base y el almohadillado directamente debajo del sitio sobre el cual ha sido vertida dicha agua.
Patent ES-2197713-T3 (ES)
Inventor: GARNIER JEAN-MICHEL
IPC: B65D85/57
Filed: 1999-10-21
Granted: 2004-01-01
Abstract: A multi-sleeve booklet (80) and a blank for forming a multi sleeve booklet for holding discs or the like, which booklet comprises a plurality of sleeves joined in series and folded upon each other in overlapping relationship. A panel (66) forming the spine of the booklet and for hingedly joining all the sleeves (42) together is joined to one of the opposed outermost sleeves and secured to the other outermost sleeve (32).
Patent ES-2205951-T3 (ES)
Title: Puente de impresion para impresoras de serigrafia.
Inventor: MANOUKIAN HARUTIUN
IPC: B41F15/46
Filed: 1999-05-31
Granted: 2004-05-01
Abstract: Puente de impresión para máquinas impresoras de serigrafía, que consta al menos de una barra de soporte transversal móvil y al menos un elemento de sujeción y/o ajuste (4) del rasero unido de manera deslizante a dicha barra de soporte transversal, caracterizado porque dicho elemento de sujeción y/o ajuste (4) consta al menos de una parte de conexión (10, 11) a un medio motor (13, 14) para desplazar dicho elemento a lo largo de dicha barra de soporte transversal, y porque dicha barra transversal consta de un perfil (1) que tiene al menos un asiento (2a, 2b) para el desplazamiento relativo de dicha parte (10, 11) y/o de dicho medio motor (13, 14).
Patent PL-1603609-T3 (PL)
Title: Blood treatment device with selective solute extraction
Inventor: CHEVALLET JACQUES
IPC: A61M1/36
Filed: 2004-03-15
Abstract: The device has an exchanger (1) with an inlet (2) and two fluid outlets (4, 5). An inlet line (10) is connected to the inlet (2), and an outlet line (11) is connected to the outlet (4). A treatment unit (21) has a fluid inlet (22) in fluid communication with the outlet (5), and a fluid outlet (24) in fluid communication with the inlet line (10).
Patent PL-1631175-T3 (PL)
Title: Installation for treating an object with steam
Inventor: DOOMERNIK CORNELIS
IPC: A47J27/16
Filed: 2004-06-11
Abstract: The invention relates to an installation for treating an object with steam, such as a steam cooker. The installation comprises a horizontal treatment tunnel (1) with an input section (2) at the one end and an output section (3) at the other end for input and discharge, respectively, of the object. The installation furthermore comprises at least one temperature sensor (14), a steam feed system (17-20) for feeding steam into the treatment tunnel, a controller (15) and a transport system (7) for feeding the object through the treatment tunnel. The controller is equipped to maintain an air-free zone containing saturated steam, at least in the upper section of the treatment tunnel, on the basis of the signal from the temperature sensor. According to the invention the treatment tunnel is provided at the bottom with at least one discharge pipe (9) running downwards, which at one end is in communication with the interior of the treatment tunnel via a tunnel orifice and at the other end with the environment via an environment orifice. The controller is in particular so equipped that the air-free zone containing saturated steam extends as far as the bottom of the treatment tunnel, such as into the discharge pipe. Furthermore, the temperature sensor can be provided in the discharge pipe.
Patent PL-1647041-T3 (PL)
Title: Differential switch provided with a test circuit
Inventor: KOCH PIERRE CIMIEZ PARC
IPC: H01H83/04
Filed: 2004-07-20
Abstract: The switch has an automatic power cut-off conductive branch (10) that extends along a direction transversal to a rotating axle (8) of a rotating contact (2). An automatic power cut-off conductive blade (7) connected to the contact is placed relative to the branch. The blade is placed such that it is placed against and spaced apart from the branch when the contact is in closed and open positions, respectively.
Patent PL-1660471-T3 (PL)
Title: Derivatives of hydroxamic acid as metalloproteinase inhibitors
Inventor: PAIN GILLES
IPC: C07D213/38
Filed: 2004-08-18
Abstract: A compound of formula (I), or an enantiomer or diastereoisomer thereof, or a salt, hydrate or solvate thereof: for the treatment or prophylaxis of arthritis in mammals.
Patent PL-1668002-T3 (PL)
Title: 2,4-dioxo-3-quinazolinylaryl sulfonylureas
Inventor: SCARBOROUGH ROBERT M
IPC: A61K/
Filed: 2004-09-29
Abstract: 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C<SUB>1-6 </SUB>alkyl; R<SUP>1 </SUP>is a member selected from the group consisting of H, C<SUB>1-6 </SUB>alkyl, C<SUB>1-6 </SUB>haloalkyl, C<SUB>3-5 </SUB>cycloalkyl and C<SUB>3-5 </SUB>cycloalkyl-alkyl; R<SUP>2 </SUP>is a member selected from the group consisting of H, halogen, C<SUB>1-6 </SUB>alkyl, C<SUB>2-6 </SUB>alkenyl, C<SUB>2-6 </SUB>alkynyl, C<SUB>1-6 </SUB>haloalkyl, C<SUB>1-6 </SUB>alkoxy, cyano and -C(O)R<SUP>2a</SUP>, wherein R<SUP>2a </SUP>is a member selected from the group consisting of C<SUB>1-6 </SUB>alkoxy and (C<SUB>1-6 </SUB>alkyl)<SUB>0-2 </SUB>amino; L is a 1 to 3 carbon linking group selected from the group consisting of -CH<SUB>2</SUB>-, -CH(CH<SUB>3</SUB>)-, -CH<SUB>2</SUB>CH<SUB>2</SUB>-, -CH<SUB>2</SUB>CH(CH<SUB>3</SUB>)- and -CH<SUB>2</SUB>CH<SUB>2</SUB>CH<SUB>2</SUB>-; L<SUP>1 </SUP>is a linking group selected from the group consisting of a bond and -CH<SUB>2</SUB>-; L<SUP>2 </SUP>is a linking group selected from the group consisting of a bond, -NH- and -CH<SUB>2</SUB>-; and Ar<SUP>1 </SUP>is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
Patent PL-1753934-T3 (PL)
Title: System and methods using fiber optics in coiled tubing
Inventor: LOVELL JOHN R
IPC: E21B47/12
Filed: 2005-05-26
Abstract: Apparatus having a fiber optic tether disposed in coiled tubing for communicating information between downhole tools and sensors and surface equipment and methods of operating such equipment. Wellbore operations performed using the fiber optic enabled coiled tubing apparatus includes transmitting control signals from the surface equipment to the downhole equipment over the fiber optic tether, transmitting information gathered from at least one downhole sensor to the surface equipment over the fiber optic tether, or collecting information by measuring an optical property observed on the fiber optic tether. The downhole tools or sensors connected to the fiber optic tether may either include devices that manipulate or respond to optical signal directly or tools or sensors that operate according to conventional principles.
Patent PL-1778660-T3 (PL)
Title: Process for the separation of paclitaxel and cephalomannin
Inventor: BUCHTA MARTIN
IPC: C07D305/14
Filed: 2005-07-01
Abstract: Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C<SUB>5</SUB>-C<SUB>8</SUB>) aliphatic hydrocarbon, a (C<SUB>6</SUB>-C<SUB>8</SUB>) aromatic hydrocarbon, a (C<SUB>1</SUB>-C<SUB>4</SUB>) dialkyl ether or their mixtures.
Patent PL-1698220-T3 (PL)
Title: Mobile pumping device
Inventor: DEYEN HEINZ
IPC: B60P3/22
Filed: 2006-02-28
Abstract: The transportable pump device has a centrifugal pump (11) which is connected parallel to rotary pump (12) and can produce a negative pressure in suction face of centrifugal pump during simultaneous operation with rotary pump. The difference in pressure allows liquid flow out between the pressure side and suction side of centrifugal pump operating as a closed slide valve.
Patent PL-1685763-T3 (PL)
Title: Synergism of GOS and polyfructose
Inventor: SPEELMANS GELSKE
IPC: A23L29/244
Filed: 2005-05-17
Abstract: The present invention relates to the field of prebiotics. Provided are uses for compositions comprising synergistically effective amounts of polyfructose and galactooligosaccharides (GOS).
Patent PL-1853620-T3 (PL)
Title: Antimicrobial hexapeptides
Inventor: FALLA TIMOTHY J
IPC: C07K7/06
Filed: 2006-02-07
Abstract: The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.