baber/WOPTO huggingface dataset:
Patent CY-1112141-T1 (CY)
Inventor: TILLMAN FREDRIK
IPC: H03D7/14
Filed: 2011-12-13
Abstract: A passive mixer (100) for converting a radio frequency (RF) signal to an intermediary frequency (IF) signal or vice versa. The mixer comprises a voltage controlled mixing means (110) for mixing a local oscillator signal with either an RF or IF signal. A bootstrapping technique is used for feeding back a low frequency component of the IF signal through a low-pass filter (160) to the mixing means. The mixing means (110) will follow low frequency variations of the IF signal, which will improve the linearity of the mixer. <IMAGE>
Patent CY-1113096-T1 (CY)
Title: Αντισωματα της ip-10 και οι χρησεις αυτων
Inventor: DESHPANDE SHRIKANT
IPC: C12N5/18
Filed: 2012-09-05
Abstract: Η παρούσα εφεύρεση παρέχει απομονωμένα μονοκλωνικά αντισώματα, ειδικότερα δε ανθρώπινα αντισώματα, που δεσμεύονται στην ΙΡ-10 με υψηλή συγγένεια, αναστέλλουν την δέσμευση της ΙΡ-10 στον υποδοχέα αυτής, αναστέλλουν την επαγόμενη από την ΙΡ-10 ροή ασβεστίου και αναστέλλουν την επαγόμενη από την ΙΡ-10 μετανάστευση των κυττάρων. Μόρια πυρηνικών οξέων που εγκωδικεύουν τα αντισώματα της εφεύρεσης, ανύσματα έκφρασης, κύτταρα ξενιστή και μέθοδοι για την έκφραση των αντισωμάτων της εφεύρεσης παρέχονται επίσης. Ανοσοσυζεύγματα, δι-ειδικά μόρια και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντισώματα της εφεύρεσης παρέχονται επίσης. Η εφεύρεση παρέχει επίσης μεθόδους και για την αναστολή της δραστηριότητας της ΙΡ-10 χρησιμοποιώντας τα αντισώματα της εφεύρεσης, συμπεριλαμβανομένων μεθόδων για την αγωγή διαφόρων φλεγμονωδών και αυτοάνοσων παθήσεων.
Patent CY-1116232-T1 (CY)
Title: Διαταξη διαστρωσης υγροποιημενου αδρανους υλικου για την ταφη μιας υποβρυχιας σωληνωσης, καθως και μεθοδος διαστρωσης του ρευστοποιημενου αδρανους υλικου πανω απο μια υποβρυχια σωληνωση
Inventor: MINOLA PAOLO
IPC: E02F5/12
Filed: 2015-03-27
Abstract: Μια διάταξη διάστρωσης (1) ρευστοποιημένου, αδρανούς υλικού, για ταφή μιας σωλήνωσης (2) σε ένα σώμα νερού (5), προορίζεται για να μετακινείται στο σώμα νερού (5) σε μια κατεύθυνση μετακίνησης (D) κατά μήκος της σωλήνωσης (2) και επάνω απ' αυτήν και έχει μια καρίνα (7), η οποία εκτείνεται κατά μήκος ενός διαμήκους άξονα (Α), στεγάζει τουλάχιστον έναν θάλαμο διαστολής (10, 11, 12) για το ρευστοποιημένο, αδρανές υλικό, συνδέεται με τουλάχιστον μία θυρίδα τροφοδοσίας (8) για τροφοδοσία του ρευστοποιημένου, αδρανούς υλικού στον θάλαμο διαστολής (10, 11, 12) και έχει έναν αριθμό θυρίδων εξόδου (9) που προορίζονται για να απελευθερώνουν το ρευστοποιημένο, αδρανές υλικό από τον θάλαμο διαστολής (10, 11, 12) κοντά στη σωλήνωση (2) και οι οποίες συνολικά ορίζουν μια διατομή ροής μεγαλύτερη από τη διατομή ροής της θυρίδας τροφοδοσίας (8).
Patent CY-1116413-T1 (CY)
Title: Καινοφανη πληρως-ανθρωπινα μονοκλωνικα αντισωματα anti-vap-1
Inventor: SMITH DAVID
IPC: C12N15/11
Filed: 2015-06-23
Abstract: Καινοφανή πλήρως-ανθρώπινα μονοκλωνικά αντισώματα αντι-VAP-1 και θραύσματα εξ αυτών αποκαλύπτονται. Πυρηνικά οξέα εγκωδικεύοντας αντισώματα αντι-VAP-1 ή θραύσματα εξ αυτών, ως επίσης και ανύσματα έκφρασης και κύτταρα ξενιστών ενσωματώνοντας αυτά τα πυρηνικά οξέα για την ανασυνδυασμένη έκφραση των αντισωμάτων αντι-VAP-1 αποδίδονται επίσης. Οι φαρμακευτικές συνθέσεις περιλαμβάνοντας τα εν λόγω αντισώματα και οι χρήσεις των θεραπευτικών ειδών εξ αυτών αποκαλύπτονται επίσης.
Patent CY-1119289-T1 (CY)
Title: Παραγωγα 1,3-διυδρο-2η-βενζιμιδαζολ-2-ονης υποκατεστημενα με ετεροκυκλικους δακτυλιους ως αντι-ιικοι παραγοντες αναπνευστικου συγκυτιακου ιου
Inventor: TAHRI ABDELLAH
IPC: C07D471/04
Filed: 2017-07-18
Abstract: Η παρούσα εφεύρεση αναφέρεται σε νέα παράγωγα 1,3-διυδρο-2Η-βενζιμιδαζολ-2-όνης υποκατεστημένα με ετεροκυκλικούς δακτυλίους που έχουν τον τύπο (I) στερεοϊσομερείς μορφές αυτών, και τα φαρμακευτικώς αποδεκτά άλατα προσθήκης, και τα επιδιαλυτωμένα σύμπλοκα αυτών, όπου τα R4, R5, Ζ και Het έχουν την έννοια που ορίζεται στις αξιώσεις. Οι ενώσεις σύμφωνα με την παρούσα εφεύρεση είναι χρήσιμες ως αναστολείς στον αναδιπλασιασμό του αναπνευστικού συγκυτιακού ιού (RSV). Η εφεύρεση αφορά περαιτέρω την παρασκευή τέτοιων νέων ενώσεων, συνθέσεων που περιέχουν αυτές τις ενώσεις, και των ενώσεων για χρήση στη θεραπευτική αντιμετώπιση της λοίμωξης αναπνευστικού συγκυτιακού ιού.
Patent CY-1119435-T1 (CY)
Title: Σκευασμα για αντισωμα εναντι- αλφα4βητα7
Inventor: DILUZIO WILLOW
IPC: C07K16/28
Filed: 2017-10-11
Abstract: Περιγράφονται σκευάσματα αντισώματος που περιλαμβάνουν ένα μίγμα από ένα μη-αναγωγικό σάκχαρο, ένα αντίσωμα έναντι-α4β7 και τουλάχιστον ένα αμινοξύ. Τα αποκαλυπτόμενα σκευάσματα έχουν βελτιωμένη σταθερότητα, μειωμένο σχηματισμό συσσωματωμάτων και μπορούν να επιβραδύνουν την αποδόμηση του αντισώματος έναντι α4β7 εντός αυτών, ή επιδεικνύουν οποιουσδήποτε συνδυασμούς αυτών. Η παρούσα εφεύρεση περαιτέρω παρέχει ένα ασφαλές σχήμα δοσολογίας αυτών των σκευασμάτων αντισώματος, το οποίο ακολουθείται εύκολα και το οποίο έχει ως αποτέλεσμα μία θεραπευτικά αποτελεσματική ποσότητα του αντισώματος έναντι-α4β7 in vivo.
Patent CY-1124007-T1 (CY)
Title: Στοματικες δοσολογικες μορφες παρατεταμενης απελευθερωσης τοφασιτινιμπης
Inventor: HERBIG SCOTT MAX
IPC: A61K9/28
Filed: 2021-03-29
Abstract: Η παρούσα εφεύρεση αναφέρεται σε στοματικά σκευάσματα παρατεταμένης απελευθέρωσης τοφασιτινίμπης και φαρμακευτικώς αποδεκτών αλάτων αυτής. Τα σκευάσματα που περιγράφονται εδώ έχουν επιθυμητά φαρμακοκινητικά χαρακτηριστικά.
Patent CY-1124147-T1 (CY)
Title: Ρυθμιστης υποδοχεα ανδρογονων για τη θεραπευτικη αντιμετωπιση του καρκινου του προστατη και νοσων σχετιζομενων με υποδοχεα ανδρογονων
Inventor: JUNG MICHAEL E
IPC: A61K31/4166
Filed: 2021-05-14
Abstract: Μια ένωση υδαντοΐνης σύμφωνα με τον χημικό τύπο II ή ένα φαρμακευτικά αποδεκτό άλας αυτής, όπου το Het είναι ομάδα πυριδιλίου χρήσιμη για την πρόληψη ή τη θεραπευτική αντιμετώπιση υπερπολλαπλαστιαστικών νόσων ή διαταραχών.
Patent HR-P20090573-T1 (HR)
Title: Method for solubilizing, dispersing, and stabilizing materials, products manufactured according to said method, and use thereof
Inventor: STROBEL HANSPETER
IPC: A23L33/155
Filed: 2009-10-28
Abstract: Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer.
Patent SI-1905261-T1 (SI)
Title: Optimising the operational times and cell change performance of mobile terminals
Inventor: KLATT AXEL
IPC: H04W36/30
Filed: 2006-07-12
Abstract: The invention at hand involves a method and an arrangement for optimizing the operational times and cell exchange performance of mobile terminals in a mobile communication network having adjacent radio cells. The mobile terminal temporarily stores network specific characteristics for adjacent radio cells which are not suitable for cell exchange when the mobile communication network is in operation and it uses said characteristics as decision criteria for cell exchange, and said information is used, in particular, to exclude said adjacent radio cells from additional radio technical measurements and identification methods. By implementing the terminal performance according to the inventive method, it is possible to significantly increase the operational times and the cell exchange performance of a mobile terminal in specific situations and to improve the service for a mobile radio customer. The inventive device can also be used for mobile terminals according to GSM or UMTS standard, and also for other radio network technology (for example, wireless LAN (W-LAN), cdma2000, WiMAX, WiBro, enhanced UTRAN, etc.).
Patent SI-2012592-T1 (SI)
Title: Fungicidal compositions
Inventor: HAAS ULRICH JOHANNES
IPC: A01N37/00
Filed: 2007-04-04
Abstract: A composition for control of diseases on useful plants or on propagation material thereof caused by phytopathogens, comprising (A) a compound of formula (I) or a tautomer of such a compound; and component (B) and component (C) are pesticides as described in claim 1.
Patent SI-2126150-T1 (SI)
Title: Cold work tool steel with outstanding weldability
Inventor: VALLS ISAAC
IPC: C22C38/06
Filed: 2008-01-11
Abstract: A cold work tool steel with average or above wear resistance, a hardness in excess of 60 HRc and a very good toughness but with considerably lower carbon contents leading to highly improved weldability is obtained by combining the presence of primary carbides (or alternatively nitrides and/or borides) with other strengthening mechanisms like precipitation hardening or even solid solution. Vanadium rich MC type carbides, modified with refractory metal additions, present the best compromise of hardness and fracture toughness for several applications, while for other applications harder carbides, such as Ti carbides or Ti mixed carbides (primarily with V, Mo and/or W) will be the preferred ones, alternatively using Zr and Hf mixed carbides.
Patent TR-200000929-T1 (TR)
Inventor: HILBERER EDUARD
IPC: B60T17/02
Filed: 1999-07-23
Abstract: A compressed-air processing system, notably for motor vehicles, includes, in a housing, an electromagnetic pressure regulator and a multicircuit safety valve having at least one load circuit connected to it. Each load circuit can be locked separately by an assigned pressure control unit. Reliable and economical operation of the system is achieved by positioning a pressure limiter between at least one of the pressure control units and the pressure regulator output and by the fact that in the zero-current state, the pressure limiter acts on a supply hole for the control unit so as to limit the output pressure to a defined value.
Patent TR-200002802-T1 (TR)
Title: Sayaçlı doz infüzyon pompası ve yöntemi.
Inventor: ROSS STEPHEN O
IPC: A61M1/00
Filed: 1999-12-03
Abstract: Damardan uygulama takimi (14) olup asagidaki parçalardan meydana gelmektedir: eksenel olarak ileri hareket eden, bir pompa kafa girisi (110) ve bir pompa kafa çikisi (112) olan bir pompa kafasi (98); birinci ucu likit baglantiyla pompa kafa girisine (110) baglanan, ikinci ucu bir kilit rezervuariyla likit baglanti için  adapte edilmis , birinci ve ikinci ucu olan bir giris borusu (96); birinci ucu likit baglantiyla pompa kafa çikisina (112) baglanan, ikinci ucu bir hastanin damariyla likit baglanti için adapte edilmis,birinci ve ikinci ucu olan bir çikis borusu (100). Eksenel olarak ve ileri geri hareket eden pompa kafasinin (98) pompa kafa girisi (110) ve pompa kafa çikisi (112) pompa kafasina (98) eksenel konumdadir. Bir damardan infüzyon pompasi (80) uygulama takimini (14) içine almakta ve pompa kafasiyla (98) islevsel baglantida olan bir lineer ileri geri sevk aygiti (132) içermektedir. Likit rezervuari bir siringa (94) olabilir ve siringadan likit siringa çikisinda(198)DEVAMIVAR
Patent DE-3783981-T2 (DE)
Inventor: YODA SHIGERU C O OMRON TATEISI
IPC: G11B7/12
Filed: 1987-09-11
Granted: 1993-09-02
Abstract: An optical data storage accessing apparatus which includes a first light projecting unit (A1) including a laser diode (1) for projecting data recording light (L1) onto a data storage medium (10), a second light projecting unit (A2) for projecting data reading light (L2) onto the data storage medium (10), and a light receiving unit (B). The light receiving unit (B) receives the data reading light (L2) after it is reflected by the data storage medium (10) to read data recorded on the data storage medium. An optical unit (3) joins the data recording light (L1) and the data reading light (L2) and separates data reading light reflected from the data storage medium (10) from the data recording light (L1).
Patent DE-3853284-T2 (DE)
Inventor: RICHARDS WILLIAM
IPC: A61B17/064
Filed: 1988-10-28
Granted: 1995-08-24
Abstract: A microsurgical stapling system useful for suturing delicate tissue with miniature staples is disclosed. The system comprises a stapler and a staple magazine (20). The stapler comprises a housing (100), a staple support and ram assembly (200), a driver body (300), and a driver assembly (400). The staple magazine (20) comprises a grid-like framework to which a plurality of staples (21) are attached in parallel, spaced-apart fashion.
Patent DE-3854672-T2 (DE)
Inventor: ISHIDA MITSUYOSHI TAITO CORPOR
IPC: A63F13/21
Filed: 1988-12-21
Granted: 1996-05-02
Abstract: The gear is equipped with a mechanism by which a steering wheel is rotated in accordance with the steering operation of a player and returns automatically to a neutral position. An end cam which receives the resilient force of a compression coil spring sets normally a steering wheel to a neutral position through a guide roller. When the player rotates the steering clockwise, for example, the guide roller rotates clockwise along with a steering shaft, so that the end cam moves in accordance with the rotating angle of the steering wheel in the axial direction of the shaft. When the wheel is released, the end cam returns the steering to the neutral position through the guide roller upon reception of the resilient force of the coil spring without the need of a reversing operation. The steering gear has a detector for the rotating angle and rotating direction of the shaft to operate a car on a display. @(21pp Dwg.No.2/6)@.
Patent DE-60001972-T2 (DE)
Inventor: CORMA CANOS AVELINO
IPC: C01B33/26
Filed: 2000-07-07
Granted: 2004-03-04
Abstract: The invention concerns a microporous crystalline material, with a characteristic X-ray diffractogram, made up by oxygen tetrahedra and one metal (T<+4> and T<+3>) with the possibility of introducing surface acidity produced by the substitution in the network of some T<+4> cations (normally Si<+4>) by T<+3> cations (normally Al<+3>), which gives rise to a structural charge deficiency which can be offset by protons, Br¦nsted acidity, and/or cations with a high charge-radium ratio, Lewis acidity. The method of preparation is based on the modification of the laminar structure of a mixed oxide (normally SiO2, Al2O3) synthesized from a gel treated under controlled hydrothermal conditions, intercalating organic molecules with a proton-acceptor group and a long hydrocarbonic chain between its laminae. The intercalated material has laminae with a significant separation between them due to the presence between them of the organic chains. The swollen material is then treated in order to separate and disperse the laminae. The final washing and subsequent calcination gives rise to a microporous material with a high external surface, the object of this invention.
Patent DE-60003295-T2 (DE)
Inventor: CAMINADE ANNE-MARIE
IPC: A01P3/00
Filed: 2000-03-07
Granted: 2004-05-06
Abstract: The invention concerns pesticide and/or insecticide and/or plant growth regulating compositions comprising specific dendrimers, said compositions being, in particular, useable for agriculture and/or public health or domestic hygiene; the invention also concerns methods for treating and/or protecting crops and/or for public health and domestic hygiene using said compositions. The invention further concerns specific dendrimers.
Patent DE-60006690-T2 (DE)
Inventor: TAKEUCHI TOMIO
IPC: C12P17/16
Filed: 2000-08-11
Granted: 2004-09-23
Abstract: There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) <CHEM> wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.
Patent DE-60008800-T2 (DE)
Inventor: VOLK M
IPC: H03K19/00
Filed: 2000-12-06
Granted: 2005-02-10
Abstract: A first buffer impedance value is established by electronically adjusting a first impedance between a first voltage source and a first reference point until the potential at the first reference point has a predetermined relationship to a reference voltage. A second buffer impedance value is established by adjusting the impedance between a second reference point and a second voltage source, until the potential at the second reference point has a predetermined relationship with the reference voltage.
Patent DE-60010847-T2 (DE)
Inventor: SAVILLE L
IPC: G06F11/36
Filed: 2000-08-21
Granted: 2005-06-16
Abstract: A method is provided for debugging a program thread without overwriting a breakpoint indicator that is substituted in the thread for an opcode of the thread.  After reaching the breakpoint, the opcode is read into a dedicated register for utilization.  A method is also provided for facilitating debugging of a thread while allowing at least one other thread to continue running.
Patent DE-60012741-T2 (DE)
Inventor: CHOW CHOI
IPC: B64C25/00
Filed: 2000-06-29
Granted: 2005-01-13
Abstract: An aircraft, aircraft landing gear and apparatus including at least one attachment (15,17,76,93,94,111) for noise reduction purposes are provided. Such attachments are shaped and positioned on the landing gear to deflect air away from noise-inducing components (64,65) of the landing gear and to permit deflection and articulation movement and also stowage of the landing gear whilst the attachments are installed thereon. The attachments are not designed to be drag-reducing.
Patent DE-60012958-T2 (DE)
Inventor: FOLEY T
IPC: A61B17/02
Filed: 2000-10-20
Granted: 2005-08-11
Abstract: Methods and instrumentation for surgical procedures relating to preparation of vertebral bodies and a disc space for insertion of spinal implants is disclosed. One instrument is a shim having a blade and a shaft having a first end connected with the blade. The blade is inserted into a distracted disc space to maintain distraction during subsequent procedures. Another instrument is a driver for driving the blade of the shim into the distracted disc space. Various methods contemplate the use of these instruments to maintain disc space distraction during disc space preparation for receiving an implant.
Patent DE-60013785-T2 (DE)
Inventor: LILJERYD GUSTAF
IPC: H03M13/37
Filed: 2000-01-26
Granted: 2005-09-29
Abstract: The present proposes new methods and an apparatus for enhancement of source coding systems utilising high frequency reconstruction (HFR). It addresses the problem of insufficient noise contents in a reconstructed highband, by Adaptive Noise-floor Addition. It also introduces new methods for enhanced performance by means of limiting unwanted noise, interpolation and smoothing of envelope adjustment amplification factors. The present invention is applicable to both speech coding and natural audio coding systems.
Patent DE-60027570-T2 (DE)
Inventor: KLIMYUK VICTOR
IPC: C12N15/81
Filed: 2000-08-07
Granted: 2007-02-15
Abstract: Disclosed are methods of making plant artificial chromosomes. In one embodiment, the method entails: (a) preparing recombinant protoplasts of a first plant species containing an exogenous nucleic acid (e.g., DNA) of interest; (b) producing chromosome fragments of chromosomes contained in the recombinant protoplasts; (c) fusing the recombinant protoplasts of (b) with protoplasts of a second plant species to produce fused protoplasts, wherein the first and second plant species may be the same or different; and (d) identifying fused protoplasts of (c) or cells derived from the fused protoplasts of (c) that contain chromosome fragments that exhibit normal plant chromosomal properties. The chromosome fragments may be moved from one plant species to another. Whole plants, plant cell cultures and intermediates of same are also provided.
Patent DE-60105727-T2 (DE)
Inventor: BERGER CHRISTOPH
IPC: A43B13/14
Filed: 2001-07-24
Granted: 2005-11-10
Abstract: The present invention relates to a shoe, in particular a sports shoe with an insole layer (1) with first openings (2, 3), a support layer (10) with second openings (11, 12) which partially overlap the first openings (2, 3) and an outsole layer (30) with at least one third opening (33, 34, 35) which at least partially overlaps the second openings (11, 12).
Patent DE-60109765-T2 (DE)
Inventor: FAVRE PASCAL
IPC: F16K3/28
Filed: 2001-05-18
Granted: 2006-02-02
Abstract: The invention concerns a piston wherein the mobile screw ( 2 ) is engaged in the bolt ( 8 ) integral with the mobile assembly ( 1 ). It is provided with a cylindrical axial housing ( 10 ) wherein is engaged the rod ( 7 ) integral at its front end with the expander assembly ( 4 ). At the end of its front travel, the rod is retained by its flange ( 19 ) pressed on the stop ( 11 ) such that the expanding ring ( 5 ) is compressed by the thrust of the piston body ( 3 ) and causes the flexible envelope ( 6 ) to expand.
Patent DE-60112872-T2 (DE)
Inventor: BURZYNSKI STANISLAW R
IPC: A61K31/223
Filed: 2001-06-26
Granted: 2006-06-14
Abstract: Pharmaceutical compositions are disclosed comprising one or more compounds selected from the group consisting of phenylacetylglutamine, phenylacetylisoglutamine, and phenylacetic acid, in addition to pharmaceutically-acceptable salts, analogs, and precursors thereof, and optionally also isoglutamine, with a pharmaceutically-acceptable carrier, diluent, or excipient, useful in the treatment or prevention of hypercholesterolemia and hypertriglyceridemia. Also disclosed are methods for treating or preventing hypercholesterolemia and hypertriglyceridemia using the pharmaceutical compositions.
Patent DE-60116308-T2 (DE)
Inventor: HUNDEBOEL SOEREN
IPC: F27D13/00
Filed: 2001-01-19
Granted: 2006-09-07
Abstract: A description is made of a method as well as an apparatus for manufacturing cement clinker from particulate cement raw material by which method fresh raw material is preheated and possibly precalcined in a suspension preheater (1, 3) by heat exchange with hot exhaust gases, and preheated and possibly precalcined material is finally calcined and burned into clinker in a rotary kiln (7), hot clinker from the rotary kiln is cooled in a cooler (9) and dust is separated from the exhaust gases from the preheater in a filter arrangement (11). The method and the apparatus are peculiar in that dust from the filter arrangement (11) is introduced into the material inlet end of the rotary kiln (7) in a direction which is contrary to the flow direction of the kiln gases.Hereby is obtained a significant reduction of coatings on the walls of the riser duct.
Patent DE-60117835-T2 (DE)
Inventor: BEAULIEU FRANCIS
IPC: A61P29/00
Filed: 2001-09-27
Granted: 2006-10-19
Abstract: Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y<SUB>1</SUB>, Y<SUB>2</SUB>, and R<SUB>2-</SUB><SUB>4 </SUB>are as defined in the specification.