baber/WOPTO huggingface dataset:
Patent NZ-592039-A (NZ)
Title: Combination therapy for the treatment of ocular neovascular disorders
Inventor: SHIMA DAVID
IPC: A61K45/00
Filed: 2004-08-26
Abstract: 592039 Disclosed is a pharmaceutical composition comprising: (i) a PDGF antagonist that is an antibody or binding fragment thereof; (ii) a VEGF-A antagonist that is an antibody or binding fragment thereof; and (iii) a pharmaceutically acceptable carrier, wherein the PDGF antagonist and the VEGF-A antagonist are present in an amount that is effective for treating a neovascularization disorder. Further disclosed is the use, in the manufacture of a medicament, of (i) a PDGF antagonist that is an antibody or binding fragment thereof; and (ii) a VEGF-A antagonist that is an antibody or binding fragment thereof, for treating or preventing an ocular neovascular disorder. Further disclosed is a pharmaceutical combination comprising: (i) a PDGF antagonist that is an antibody or binding fragment thereof; and (ii) a VEGF-A antagonist that is an antibody or binding fragment thereof, wherein the PDGF antagonist and the VEGF-A antagonist are formulated in an amount that is effective for treating a neovascularization disorder and formulated for sequential or simultaneous administration.
Patent NZ-593418-A (NZ)
Title: Imidazole compounds for use as enzyme inhibitors
Inventor: KISS LASZLO ERNO
IPC: A61K31/33
Filed: 2009-12-23
Abstract: ABSTRACT - 593418 The disclosure relates to azole derivative compounds represented by structural formula shown herein and compositions thereof, wherein the variables are as defined in the specification. These compounds are suitable for inhibiting the enzyme fatty acid amide hydrolase (FAAH), and are useful for treating or preventing condition or disorder whose development or symptoms are linked to substrates of the FAAH enzyme, wherein the condition or disorder is selected from appetite regulation, obesity, metabolic disorders, cachexia, anorexia, pain, inflammation, neurotoxicity, neurotrauma, stroke, multiple sclerosis, spinal cord injury, Parkinson's disease, levodopa-induced dyskinesia, Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, dystonia, amyotrophic lateral sclerosis, Alzheimer's disease, epilepsy, schizophrenia, anxiety, depression, insomnia, nausea, emesis, alcohol disorders, drug addictions such as opiates, nicotine, cocaine, alcohol and psychostimulants, hypertension, circulatory shock, myocardial reperfusion injury, atherosclerosis, asthma, glaucoma, retinopathy, cancer, inflammatory bowel disease, acute and chronic liver disease such as hepatitis and liver cirrhosis, arthritis and osteoporosis.
Patent NZ-594009-A (NZ)
Title: Targeted cryptosporidium biocides
Inventor: IMBODEN MICHAEL
IPC: C07K16/00
Filed: 2010-01-13
Abstract: Provided is a composition comprising a recombinant fusion protein, wherein said fusion protein comprises an immunoglobulin that binds to a Cryptosporidium spp., wherein said immunoglobulin comprises a pair of polypeptides comprising a heavy chain and a light chain with specified sequences for the variable regions, including sequences at least 95% identical to the inventive sequences; and wherein said immunoglobulin is joined to at least a portion of a protein biocide molecule. The composition can be used in a medicament for humans or animals against Cryptosporidium infection.
Patent NZ-594843-A (NZ)
Title: Method or system using biomarkers for the monitoring of a treatment
Inventor: NAKAGAWA KAZUHIKO
IPC: G01N33/50
Filed: 2010-03-11
Abstract: NZ 594843 Disclosed is a method for the monitoring of the treatment of an individual with the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, said method comprising determining whether a sample from said individual comprises a biomarker in an amount that is indicative for said treatment, wherein said biomarker is the number of cells selected from the group consisting of: VEGFR2+CD45dimpY+ cells; VEGFR2+pY+ cells; CD34+CD45dim CD133+CD117- cells; CD34+CD45dim CD133-CD117+ cells; CD34+CD45dimCD133+ cells; CD34+CD45dimCD117+ cells; and CD34+CD45dim CD133+CD117+ cells, wherein the method comprises the step of measuring the number of said cells in said sample.
Patent NZ-596934-A (NZ)
Title: Watercraft with stepped hull and outboard fins
Inventor: HANSEN WILLIAM M
IPC: B63B1/26
Filed: 2010-06-15
Abstract: A watercraft has a stepped hull (100) including a forward hull portion (103), a first stepped hull portion (106), and optionally a second stepped hull portion (108). Outboard ram air fins (120) extend outwardly from the hull and downwardly along the stepped hull portions. Outboard strakes (110, 112) are fixed to the stepped hull portions, and may be tapered to define ports thereto. During planing operation the channels defined by the fins compress the incoming air which is thereby at least partially forced under the stepped hull portion. In level operation the flow through the channels tends to keep the stepped hull portions in good contact with the water.
Patent NZ-607103-A (NZ)
Title: A water-in-oil type emulsion for treating a disease of the eye
Inventor: LALLEMAND FRÉDÉRIC
IPC: A61P27/02
Filed: 2011-09-02
Abstract: Provided is a composition comprising a water-in-oil type emulsion comprising an oil phase, a lipophilic surfactant dissolved in the oil phase, an aqueous phase dispersed in the oil phase and a hydrophilic therapeutic agent dissolved in the aqueous dispersed phase. The composition is for intraocular injection to treat diseases or medical conditions of the eye.
Patent NZ-615069-A (NZ)
Title: Display and controls for a cpap device
Inventor: BATH ANDREW RODERICK
IPC: A61M16/16
Filed: 2009-09-17
Abstract: An apparatus for treating sleep disordered breathing comprises a flow generator to deliver a supply of air at positive pressure to a patient; a user interface and a controller in communication with the user interface and configured to control the operation of the flow generator. The user interface comprises a display configured to display a plurality of screens; and a set of controls. The flow generator is configured to couple with at least one accessory device and during a first mode of operation of the flow generator the controller determines a first screen of the plurality of screens to display on the display based on the at least one accessory device. The first screen of the plurality of screens is configured to enable adjustment of one or more parameters related to the operation of the at least one accessory device or the flow generator using the set of controls. The at least one accessory device can a humidifier and the parameter that is enabled for adjustment is a humidity parameter of the humidifier. The at least one accessory device can be a heated tube and the parameter that is enabled for adjustment is a heated tube temperature parameter. The first mode of operation can be a run mode where the flow generator is delivering the supply of positive pressure to the patient.
Patent NZ-617321-A (NZ)
Title: System and method for displaying messages in a building automation system
Inventor: SNODGRASS DARREN MARK
IPC: H04W88/16
Filed: 2009-08-12
Abstract: Disclosed is a system for providing information to one or more devices in a building automation system. The system includes an information centre (110) that has a subscriber database. The subscriber database has a plurality of subscribers and each subscriber has an associated message delivery address and received message characteristics. One or more servers (112) receive information from one or more sources and extract portions (124, 126) of the received information to send the portions (124, 126) to a message delivery addresses in the subscriber database. The portions (124, 126) sent to a message delivery address are based on the received message characteristics of the subscriber associated with the message delivery address. A building automation system includes a plurality of devices, wherein the message delivery address corresponds to a device in the building automation system, and one or more devices act upon the received one or more portions (124, 126) of information.
Patent NZ-626130-A (NZ)
Title: Framework for creating interactive digital content
Inventor: HUDSON PAUL
IPC: G06F17/24
Filed: 2012-11-15
Abstract: Disclosed is a system for creating an interactive digital publication in a mobile device framework. The system comprises a processor and an element creation module (912) configured to control the processor to create one or more layers on a first rendition of a first digital page in the interactive digital publication. The layer is configured to import and present a digital asset on the digital page. The system also includes an interactivity adder module (916) configured to control the processor to associate an action with the layer. The action is at least one of interactivity and behaviour. A layout management module (914) is included and configured to control the processor to analyse a first layer created by the element creation module (912) and to perform a predetermined action based on the analysis.
Patent NZ-628886-A (NZ)
Title: Ammunition magazine
Inventor: FIRZPATRICK RICHARD
IPC: F41A9/70
Filed: 2013-01-17
Abstract: Disclosed is a new interface for a magazine follower (20) and floor plate (10) is used to provide greater stability to the round stack and a more sturdy system overall. The floor plate (10) is designed with two opposite legs, the rear (24) being shorter than the front leg (22) so as to facilitate travel throughout the magazine and clearing of accumulated dirt and debris. The floor plate (10), in one embodiment, utilizes a lock plate (12) that is shaped and sized to become a shoe for the compressed spring (3) and associated follower (20). In an alternate embodiment, the floor plate (30) itself serves the purpose and, with provided teeth (36, 38), directly fastens to the magazine casing (2) at notches (6, 8) manufactured in the magazine casing for that purpose. Other enhancements to the magazine include at least one matrix of divots (5) to provide a paint surface, an over-insertion stop and lower rear geometry to aid in clearing debris and grit.
Patent NZ-631602-A (NZ)
Title: Barley with very low levels of hordeins
Inventor: Malcolm James BLUNDELL
IPC: C12N15/09
Filed: 2014-06-13
Abstract: Disclosed is a barley plant which produces grain comprising about 50ppm or less hordeins, wherein the grain is homozygous for an allele of the Hor2 locus where most or all of the B-hordein encoding genes have been deleted, the grain is homozygous for a null allele of the gene encoding D-hordein at the Hor3 locus, and the grain is homozygous for an allele at the Lys3 locus of barley which results in the grain lacking C-hordeins. Further provided is a method of producing a food or malt-based beverage ingredient, or a food or a malt-based beverage, the method comprising (i) processing barley grain comprising about 50 ppm or less hordeins to produce malt, wort, flour or wholemeal, and/or (ii) mixing barley grain, or malt, wort, flour or wholemeal produced from said grain, with at least one other food or beverage ingredient, wherein the barley grain, malt, wort, flour or wholemeal comprises about 50 ppm or less hordeins, thereby producing the food or malt-based beverage ingredient, food or malt-based beverage.
Patent NZ-700805-A (NZ)
Title: Devices and methods for additive manufacturing of implant components
Inventor: MILLER BOB
IPC: A61F2/38
Filed: 2013-04-13
Abstract: There is a need in the art for methods, techniques, devices and systems to ensure the availability of “patient-specific” and/or “patient engineered” implant components for a scheduled surgery in a cost effective and efficient manner. Accordingly, there is disclosed herein a method of additive manufacturing of a joint implant (100) which has one or more articular surfaces and one or more bone-facing surfaces (15, 17). A design for the implant (100) is aligned relative to a substrate (30, 120) in a manufacturing apparatus. One or more support structures (110, 115, 160, 200) are provided contacting one or more portions (165, 210) of the implant (100) which is to be supported, and one or more support structures (110, 115, 160, 200) are removed from the implant (100). In one or more embodiments, none of the one or more support structures (110, 115, 160, 200) contacts the one or more articular surfaces nor the one or more bone-facing surfaces. By avoiding support contact with such surfaces, the time and expense associated with implant manufacture can be minimized.
Patent NZ-719076-A (NZ)
Title: Inhibitors of kras g12c
Inventor: LI LIANSHENG
IPC: A61P35/00
Filed: 2014-10-10
Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
Patent NZ-724952-A (NZ)
Title: Packing box and box manufacturing apparatus
Inventor: MAKIUCHI TAKAFUMI
IPC: B65D5/64
Filed: 2014-09-05
Abstract: Disclosed is a packing box with a folded insert for positioning stacked products or bottles that is easier to assemble. The packing box (10) is provided with: a bottom wall (12); end walls (13A, 13B) that stand on first edges of the bottom wall (12); side walls (15A, 15B) that stand adjacent to the end walls (13A, 13B); edge walls (20) that are connected to the side edges of the end walls (13A, 13B) via outer wall folding lines (21); foldback walls (25) that are disposed on the inner surfaces of the edge walls (20); inner walls (27) that are disposed on the inner surfaces of the end walls (13A, 13B); and reinforcing walls (26) that are continuous with the foldback walls (25) via first folding lines (29) and are continuous with the inner walls (27) via second folding lines (30). The reinforcing walls (26) protrude toward the inside from between the foldback walls (25) and the inner walls (27). Of the first and second folding lines (29, 30), the first or second folding lines (29, 30) that are located on the outer wall folding line (21)-side of the apex of the protrusion are disposed at a distance (L3) from the outer wall folding lines (21) in that a stage collapsed portion (19) where a panel thickness of the paper-made corrugated board sheet is reduced by compression is formed on the reinforcing panel (26) with a predetermined width so as to include the third fold line (31).
Patent NZ-735131-A (NZ)
Title: Compositions and methods of use of phorbol esters
Inventor: CHANG RICHARD L
IPC: A61P31/18
Filed: 2008-01-30
Abstract: Use of 12-O-tetradecanoylphorbol-13-acetate (TPA / phorbol-12-myristate-13-acetate / PMA) for the treatment of HIV/AIDS.
Patent NZ-736238-A (NZ)
Title: Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
Inventor: ANDERSON ANNALIESA SYBIL
IPC: C07K16/12
Filed: 2016-04-29
Abstract: The invention relates to an immunogenic composition comprising six distinct polysaccharide-protein conjugates, wherein: (i) the polysaccharide in each of the six conjugates is a capsular polysaccharide selected from the group consisting of group B streptococcus (GBS) serotypes Ia, Ib, II, III, IV, and V; (ii) the protein in each conjugate is CRM197; and (iii) the capsular polysaccharide in each conjugate has a sialic acid level of greater than 60%. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
Patent NZ-746878-A (NZ)
Title: Systems and methods for providing data privacy in a private distributed ledger
Inventor: VOELL DAVID
IPC: G06Q20/06
Filed: 2017-03-31
Abstract: Systems and methods for providing data privacy in a private distributed ledger are disclosed. According to another embodiment a distributed ledger network may include a first node comprising a first node computer processor and hosting a central ledger comprising a plurality of entries for public transactions and private transactions, wherein the entries for public transactions comprise transaction payloads for the respective public transaction, and the entries for private transactions comprise a cryptographic hash digest of a transaction payload for the respective private transaction; and a plurality of second nodes each comprising a second node computer processor and hosting a public database comprising the public transactions, and a private database comprising transaction payloads for the private transactions to which the node is a party.
Patent NZ-768594-A (NZ)
Title: Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
Inventor: SHUBINSKY GARY
IPC: A61M31/00
Filed: 2017-06-08
Abstract: An infusion system configured to automatically control an infusion pump, the infusion system comprising an infusion pump configured to pump an infusion fluid along a flow path; a first acoustic sensor positioned at a first location along the flow path, the first acoustic sensor configured to detect a first acoustic signal, wherein the first acoustic signal travels upstream towards the first acoustic sensor; a second acoustic sensor positioned at a second location downstream from the first acoustic sensor along the flow path, the second acoustic sensor configured to detect a second acoustic signal, wherein the second acoustic signal travels downstream towards the second acoustic sensor; and a controller configured to: determine a first volumetric flow rate of the infusion fluid based on the detected first acoustic signal and the detected second acoustic signal, and control the infusion pump to pump the infusion fluid at a second volumetric flow rate based on the detected first volumetric flow rate, wherein the first volumetric flow rate of the infusion fluid is calculated over each stroke of the infusion pump based on using a periodicity in flow of the infusion fluid along the flow path.
Patent RU-94009622-A (RU)
Inventor: ZIBOROV V A
IPC: C04B35/66
Filed: 1994-03-21
Abstract: FIELD: methods for protection of building products, mainly, fragile ones, from destruction by pulse heat effect; may be used in engineering fields operating under conditions of pulse high temperatures, for instance, nuclear, metallurgical, space technologies, etc. SUBSTANCE: method for thermal protection of building products by local application to surface to be protected of easily evaporating substances in the form of granules, for instance, of cone-shaped ones whose bases are adjacent to protected surface. Thermal protective coating is applied in the form of net formed by regularly located intercrossing stripes which form open (nonprotected) areas and covered (protected) areas by granules. In so doing, the ratio between the length of nonprotected area of surface to its width does not exceed 9, and relation between the width of the nonprotected area to the thickness of protected material measured by normal to the nonprotected surface does not exceed 4, and total area of nonprotected areas with respect to the area of protected surface amounts from 30 to 40%. Granules may be made of adhesive mixture, for instance, silicate cement or sealing compound. Granules may be located inside the building products at their surface during their formation. EFFECT: higher efficiency. 4 cl, 3 dwg
Patent RU-94011261-A (RU)
Inventor: VLASOV M S
IPC: C12N15/11
Filed: 1994-03-28
Abstract: FIELD: biotechnology, genetic engineering, selection. SUBSTANCE: method involves the isolation of living organism DNA which after fragmentation and fractionation is subjected for hybridization with new probe as human DNA fragment (size is 485 nucleotide pairs). This DNA fragment has repeating trinucleotide TCC and shows the following structure: GATCTCGCTG GGAGCTGTAG ACCGGAGGTG TTCCTATTTG GCCATCTTGG AAGCGACTTC CTCCTTCCTT TTCTGAGTTT CAAAACTGTT TATATAGGTT GGGAATTTTA TTTTCTAAAA GTCTGAGTAA CTTATTTGTA AAACATTTCA AACCTGGAGG CTTTGGGGTA GATACTTCTC TTTCTCCTAT TTTTCCAAAG TTACTAATCC ATGCCAGTTG CAACAACTAG TTCTTCTCCT CCTCGTCCTC CTCCTCCTCC TCCTCCTCCT TCTTCTTCTG AGATGTATTC TCACTCTGTC ACTCAGGCTG GAGTCTCAGC TCACTTCAAC CTCTGCTCCT GGGTTCAAAC AATTCTGCCC CAGCCTCCAG TGTAGCTGGG ACTACAGGCA TGTGACACCA CTCCTGGATA CTTTTTTGTA TTTTTACTAG AGACAGGGTT TCACCATGTT AGCCAGGATG GTCTCAATCT CCTGACCTCG TGATC where: recognition site with restrictase Eco31I is at distance 460 nucleotide pairs from the left insertion end; recognition sites with restrictase GsuI are at distances 154 and 308 nucleotide pairs from the left insertion end; promoters and sites containing genes are absent. EFFECT: enhanced effectiveness of probe.
Patent RU-94014629-A (RU)
Inventor: JURGEN SHTOL TERUS
IPC: C07D413/14
Filed: 1994-04-26
Abstract: FIELD: medicine. SUBSTANCE: claimed invention describes 4- quinolyldihydropyridine derivatives of formula (I):wherein R-Rare as defined in the specification, mixture of isomers thereof or individual isomers and salts thereof which have valuable pharmacological activity, and more particularly promote heart contractions and tone of even muscles. EFFECT: improved properties of the title compounds.
Patent RU-94022861-A (RU)
Inventor: SIDOROV E P
IPC: C02F1/40
Filed: 1994-06-16
Abstract: FIELD: various branches of industry. SUBSTANCE: invention refers to physical-chemical cleaning of sewage and industrial discharges carrying oil and characterized by presence of foulings difficult to oxidize. Plant for high-efficiency cleaning of sewage containing oil includes flat filter, ozone treatment chambers of first and second stages and adsorber with injection of excessive part of ozone into it positioned in sequence. Flat filter, pressure floatation chamber and thin-layer chamber are integrated to form unit for preliminary physical-chemical cleaning. Ozone treatment chamber of first stage presents pressure ozone reactor which pipe-line of discharge of ozone-saturated liquid is put into pressure floatation chamber and into ozone treatment chamber of second stage combined with adsorber to form unit for physical-chemical aftercleaning. EFFECT: simplified design, high-efficiency cleaning of sewage and industrial discharges carrying oil. 6 cl, 1 dwg
Patent RU-94023284-A (RU)
Inventor: TURKENICH A M
IPC: B03C1/10
Filed: 1994-06-17
Abstract: FIELD: mining industry. SUBSTANCE: invention refers to process of separation of slightly magnetic materials by their magnetic properties. Enriched material is fed to parallel, long-length ferromagnetic bodies placed with clearance relative to each other and having common tangent plane located at angle to direction of magnetic field, in direction at acute angle to generators of these ferromagnetic bodies lying in common tangential plane. In this case enriched material is formed before approach to ferromagnetic bodies in the form of separate flows, spaces between flows being positioned opposite to ferromagnetic bodies and flows proper being arranged opposite to spaces between ferromagnetic bodies. Magnetic particles are brought into magnetic product on same side with reference to tangent plane of ferromagnetic bodies from which enriched material is fed. Nonmagnetic particles are brought into magnetic product through clearances between ferromagnetic bodies. In case of process of wet separation flow of fluid is brought into direct contact with flow of enriched material at point of feed of magnetic particles into magnetic product. Enriched product is fed into clearances over rectilinear trajectory. EFFECT: improved efficiency of enrichment process. 6 cl, 5 dwg