baber/WOPTO huggingface dataset:
Patent SG-11201908065Y-A (SG)
Title: Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
Inventor: PIKE KURT
IPC: A61K31/437
Filed: 2018-03-15
Abstract: I) C O () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo omioomi oviiiin mom ois (10) International Publication Number WO 2018/167203 Al (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 471/04 (2006.01) A61P 35/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 31/437 (2006.01) (21) International Application Number: PCT/EP2018/056516 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/472,080 16 March 2017 (16.03.2017) US (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 Sodertalje (SE). (72) Inventors: PIKE, Kurt, Gordon; AstraZeneca, Dar- win Building, Cambridge Science Park, Milton Road, Cambridge CB4 OWG (GB). BARLAAM, Bernard, Christophe; AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 OWG (GB). = (74) Agent: NESS, Mark, David; AstraZeneca Intellectual Property, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 Published: — with international search report (Art. 21(3)) (54) Title: DEUTERATED IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER (57) : The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where R 1 has the meanings defined herein. The specification also relates to the use of compounds of Formula (I) and salts thereof to treat or prevent ATM mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising substi- tuted imidazo [4,5- c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; and kits comprising such compounds and salts.
Patent HU-203373-B (HU)
Title: Process for producing heparin having anti-hiv activity
Inventor: CARDIN ALAN DOUGLAS
IPC: A61P37/00
Filed: 1990-01-10
Abstract: Various peptides having affinity for sulfated polysaccharides such as heparin, dextran sulfate and pentosan polysulfate are bound to resins and used in affinity chromatography to prepare anti-HIV sulfated polysaccharides.
Patent IS-1656-B (IS)
Inventor: MEIER JOHANNES
IPC: B32B3/12
Filed: 1992-07-31
Abstract: Process for manufacturing a composite panel (90) from a cellular core (41) and at least one outer layer (42) by bonding the outer layer (42) to the cellular core (41), for example with the aid of an adhesive film (84), under pressure and at elevated temperature, in which the adhesive film (84) can initially be disposed over the entire surface and tears open under the effect of heat and by being subjected to a gaseous medium in the region of the honeycomb interior and is thus concentrated at the contact points of cellular core (41) and outer layer (42). The outer layer (42) has for its part on the side facing the cellular core an adhesive layer or an adhesive film (83). The outer layer and cellular core bond to one another under the effect of pressure and temperature. <IMAGE>
Patent AT-394447-B (AT)
Title: Immersion pyrometer
IPC: G01K1/12
Filed: 1988-01-26
Granted: 1992-03-25
Abstract: Immersion pyrometer for measuring high temperatures, in particular for liquid metals, which has an outer housing 2, serving as a guard, for a temperature measuring device 11, 54, said housing having side walls and a front wall whose outer surfaces can be brought into contact with liquid media present at high temperatures, a recess 3 having inner walls being provided in the interior of the housing and the recess 3 being designed to be open on one side for the insertion and removal of the temperature measuring device 11, 54, the housing 2 completely isolating the temperature measuring device from the medium to be measured. Rapid response and a long service life of the immersion pyrometer are achieved by the housing 2 containing fireproof metal oxide and graphite, and graphite being provided in a concentration of from 10 to 35% by weight, preferably from 25 to 30% by weight, so that good thermal conductivity between the outer surface of the housing and the inner walls of the recess 3 is ensured. <IMAGE>
Patent AT-387134-B (AT)
Title: Crash helmet
IPC: A42B3/32
Filed: 1987-04-14
Granted: 1988-12-12
Abstract: Crash helmet, of which the helmet shell has, on the rear part of the neck opening, a neck guard which is preferably designed to butt closely against the neck, having a chin guard which can be released from the helmet shell and can be pivoted forwards and upwards, as a result of which the neck opening can be increased in size when the crash helmet is put on or removed, characterized by the circle-arc-shaped link plates 3 with edges, grooves or slots 3a in the circle-arc direction at the two ends of the chin guard 2 which are directed towards the helmet shell 1, and by the circle-arc-shaped pushed- in channels 4, in the helmet shell 1, which are an accurate fit for the link plates 3, it being the case that the link plates 3 have locking elements 10, 11, and arranged in the helmet shell 1, in the region of the push- in channels 4, are openings 1b, into which the locking elements 10, 11 can latch and be actuated from the outside, and that the neck guard 5, 6 is continued on the chin guard 2. <IMAGE>
Patent HU-198358-B (HU)
Inventor: KOCSIS LASZLO
IPC: H01R4/30
Filed: 1986-01-15
Abstract: A találmány tárgya zárt szigetelő kapocsházzal rendelkező és tartósínre rögzíthető villamos sorozatkapocs vezetékek bontható összekötésére, amelynek kapocsházában (1) helyezkedik el a kapocstest (2), a vezetékrögzítő (5), és lényege, hogy a szigetelő kapocsháza (1) egymáshoz záródó két félből áll, amelyek belső oldalán egymással szemben bemélyedések (9, 11) és bordák (10, 19) vannak, a kifelé nyílásokkal rendelkező bemélyedésben egyetlen fémtuskóból kiképzett kapocstest (2) van elhelyezve, a kapocstest (2) két szemközti oldalán legalább egy-egy vezeték befogadó furat (13) van, amelyek a kapocsház (1) szájnyílásaihoz (8) egytengelyűén csatlakoznak, a kapocstestben (2) ezek tengelyére merőlegesen legalább két szorító furat van kialakítva, amelyek közül egyegy a vezeték befogadó furatokba (13) torkollik, a szorító furatokhoz szorítócsavarok (4) és ezekkel alakzáró kapcsolatban álló vezeték szorítóelemek (3) csatlakoznak, a szorító furatokhoz a kapocsház (11 további nyílásai (17) vezetnek, míg a kapocsház (1) egyik felén a bemélyedéstől fallal elválasztva olyan további bemélyedés (9) van, amelybe a kapocshát (1) másik felén kialakított borda (19) illeszkedik, valamint a kapocsház (1) mindkét felében kiképzett további bemélyedések (11) egy oldalról nyitott rugófészket alkotnak. (3. ábra)  lábra -1-
Patent HU-193197-B (HU)
Inventor: BUDAI ZOLTAN
IPC: C07C301/00
Filed: 1984-02-03
Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung von neuen N-substituierten Aminopropansulfonsaeure-Derivaten der allgemeinen Formel I, worin R1 und R2 identisch oder verschieden sein koennen und fuer Wasserstoff, Halogen, niederes Alkyl oder niederes Alkoxy stehen und R Furyl oder gegebenenfalls durch ein oder mehrere Halogenatom(e) substituiertes niederes Alkyl oder Phenyl bedeutet. Die erfindungsgemaess hergestellten Verbindungen eignen sich als Wirkstoffe fuer pflanzenwuchsregulierende Mischungen. Beispielsweise werdenN-(2-Aethyl-phenyl)-N-chloracetyl-3-amino-propan-(1)-sulfonsaeure oderN-(2-6-Dimethyl-phenyl)-N-chloracetyl-3-amino-propan-(1)-sulfonsaeure und deren Salze hergestellt. Formel 1
Patent HU-206450-B (HU)
Title: Device particularly for micro-wearing-off the surface of human tissue
Inventor: ROSSO LUCIANO
IPC: A47L11/34
Filed: 1989-01-11
Abstract: Apparatus for making micro-abrasions, particularly on human tissue, includes a handle (1) having an aperture (4) which is intended to be positioned on the surface to be treated, and means for the metered supply of reducing substances (S) in a pneumatic carrier to the aperture (4) of the handle (1). The supply means comprise only a vacuum source (15) connected to the handle to draw the reducing substances (S) towards the aperture (4) of the handle (1).
Patent HU-198305-B (HU)
Inventor: FEHER PAL
IPC: C10L1/18
Filed: 1986-02-19
Abstract: Az eljárás folyamán toluolban oldott maleinsavból,
fumársavból, maleinsavanhidridből, ftálsavanhidridből
és 4 12 szénatomszámű alifás alkoholokból
adott esetben katalizátor jelenlétében észtert képeznek,
maid ennek benzolos oldatába lnlclátort kevernek
és 50 120 bar nyomáson, 120 140 °C hőmérsékleten
addig vezetnek etllérgázt, amíg a poliinerizációs
fok a 16 18 értéket el nem éri. Ezt követően
az. anyaghoz 8 -9 szénatomszámű aromás szénlddrogént
adagolnak, legfeljebb egy óra reagáltatás után a
hőmérsékletet 65-75 °C-ra, a nyomást 1 bar értékre
csökkentik és az oldószer vákuumban lepárolják.
Patent MT-P1027-B (MT)
Title: Continuous front for covering the outside walls of buildings made of modular section members and having high insulation properties
Inventor: GIOCOMELLI MARIO
IPC: E04B2/90
Filed: 1988-11-28
Abstract: The present invention relates to a continuous front or facade for covering the outside surfaces of walls of buildings, which front is made of modular section members (2, 3, 4, 5) and has high insulation properties, wherein the front supporting frame (2) is assembled by intercoupling a plurality of bearing section members (40), which have a substantially rectangular profile which is provided with a projection projecting from the middle or center line of one of the sides thereof or, in angle section members (16), from two adjacent sides,in the end portion of which a gasket (7) and coupling means for an outer tight section member can be arranged. The tightness section member (5) substantially consists of a web having,on the two faces thereof, two further projections (4) symmetrically arranged with respect to the middle line and operating as respective abutments (6) for the projection of the bearing section member,for the gasket (7) and for the coupling means.
Patent SE-331030-B (SE)
Inventor: SPILLER L
IPC: D21H23/50
Filed: 1968-01-05
Abstract: Produces paper and like products of modified surface properties by depositing electrostatically charged particles of dry starch on a water-wet web which may still be on the wire of a Fourdrinier machine. The starch particles are deposited as uniformly distributed segregated particles which remain on the surface of the paper to be swollen with the water of the web as the web is dried to bind the surface fibers to the body of the paper. The adhesive function of the starch does not require the particles to be gelatinized to the point of rupture and the paper, especially newsprint, retains its porosity. The lack of penetration of the starch into the body of the paper and its presence in the form of separated particles emphasizes the surface binding action of a small amount of starch.
Patent YU-48623-B (YU)
Inventor: VLADIMIR BEKAVAC
Filed: 1992-05-22
Abstract: Merni pretvarač razlike pritisaka za neagresivne gasove, sa membranom, lisnatom oprugom i magnetorezistivnim senzorom, kod koga su komore K1, K2 sa priključcima 1, 2, međusobom razdeljene elastičnom membranom 3, pri čemu je u središtu membrane 3 postavljena kružna pločica 4, koja je kruto vezana preko poluge 5 za slobodan kraj konzole 6 na čijem kraju je pričvršćena pločica sa permanentnim magnetom 7, naznačen time, što je na nepokretnom nosaču (9) pričvršćen magnetni senzor (8) postavljen u ravni paralelnoj sa ravni permanentnog magneta (7) i što je konzola (6) opruga.
Patent YU-45712-B (YU)
Title: Poluprovodnička pločica od monokristalnog silicijuma dijamantno kubične strukture sa smanjenim kristalografskim defektima
Inventor: JASTRZEBSKI L L
IPC: H01L29/04
Filed: 1985-04-22
Abstract: u poluprovodničkim uredjajima, koja ima glavnu površinu 24 koja je paralelna sa jednom od kristalografskih ravni (100), pri čemu je ova pločica poravnata u odnosu na referentnu poziciju korišćenjem glavnog orijentacionog odsečka 22 na svom obimu, pa zatim podvrgnuta obradi kojom se obrazuju pravolinijski elementi 16 po njenoj površini, gde elementi 16 koji sadrže silicijum nitrid, polikristalni silicijum ili silicijum dioksid, imaju ivice 18 koje stvaraju izvorišta stresova u ovoj pločici, koje su orijentisane u smerovima koji su multipli od 90 u odnosu na odsečak 22, naznač en time, što joj je glavna površina (24) paralelna sa jednom od kristalografskih ravni (100) i što je glavni orijentacioni odsečak (22) paralelan sa jednim od kristalografskih smerova 001 koji leže na glavnoj površini (24) pločice. Poluprovodnička pločica prema zahtevu 1, naznačen time, što je glavna površina (24) u suštini kružnog oblika sa odsečkom (22).
Patent ZA-83745-B (ZA)
Title: Apparatus for pressing tubular parts
Inventor: SAUDER KARL
IPC: B21D39/04
Filed: 1983-02-04
Abstract: PCT No. PCT/EP83/00024 Sec. 371 Date Oct. 4, 1983 Sec. 102(e) Date Oct. 4, 1983 PCT Filed Feb. 1, 1983 PCT Pub. No. WO83/02737 PCT Pub. Date Aug. 18, 1983.An apparatus for pressing tubular parts, more particularly for pressing or forcing pipe-unions onto pipes, sleeves or hoses. The apparatus includes a plurality of spring loaded, radially adjustable jaws and an annular piston in operative communication with the jaws. The piston can move hydraulically towards the jaws and can be returned hydraulically to its neutral position. The effective area of the piston, by means of which it is returned to its neutral position, amounts to only a fraction of the piston-area which advances the piston. The end of the piston remote from the jaws engages in an annular hydraulic cylinder, the entire cross-section of the piston which is largest at this end, forming the effective piston-area which advances the piston.
Patent ZA-89769-B (ZA)
Title: Radiation sensitive compounds
Inventor: ETHERINGTON TERENCE
IPC: C08F290/00
Filed: 1989-01-31
Abstract: A radiation sensitive material suitable for the production of radiation sensitive plates for lithographic printing plate manufacture comprises a polymer having appendent azide-substituted aromatic ester groups and sulphonyl urethane groups. The radiation sensitive compound is produced by a process in which some hydroxyl and/or epoxide groups of a polymer are reacted with an azide substituted carboxylic acid or ester forming derivative thereof, and some hydroxyl groups are reacted with a sulphonyl isocyanate.
Patent ZA-99614-B (ZA)
Title: Process for the preparation of S-alkylcysteines.
Inventor: ALLEGRINI PIETRO
IPC: C07C319/14
Filed: 1999-01-27
Abstract: A process for the preparation of S-alkylcysteines of formula wherein R is a lower or branched C1-C4 alkyl group; by S-alkylation of cysteines with dialkylcarbonates.
Patent AT-395700-B (AT)
IPC: B65G1/137
Filed: 1991-05-23
Granted: 1993-02-25
Abstract: Ejector (9) for a storage device for the reception and piece-by-piece discharge of articles, especially for a storage device of a commissioning system, in which storage device the articles are prestressed against a discharging end (22) of the storage device. In order to achieve a high level of operational reliability in such an ejector (9) provision has been made for the ejector (9) to have a stop shoulder (30) for supporting the piece nearest the discharging end (22), a lifting stamp (23) being arranged upstream of this shoulder (30) and being movable between a position which is essentially at the same level as the supporting surface for the articles to be discharged and a position corresponding to the upper edge of the stop shoulder (30). <IMAGE>
Patent AT-407677-B (AT)
IPC: G02C5/22
Filed: 1999-09-24
Granted: 2001-05-25
Abstract: In the case of the hinge joint, the bow 1, produced from wire, has a disc-shaped plastic joint body 5 which serves as hinge axis and has a coaxial circumferential groove 7 for holding a resilient wire eyelet 9, open on the circumferential side, of the bow cheek 8. In order to create advantageous design conditions, it is proposed that the bow 1 forms an end piece 2 which is widened to form a holding eye 3 for the disc-shaped joint body 5, and in which the joint body 5 is held by a pin 10 passing through the latter. It is also proposed that the joint body 5 comprises two component discs 6 whose plane of partition is perpendicular to the hinge axis and runs centrally relative to the circumferential groove 7. Another proposal is that the two component discs 6 are supported in a fashion fixed against rotation relative to the holding eye 3 via rotary stops 12 which engage in latching cutouts 13 in the holding eye 3 and project axially over the disc body. <IMAGE>
Patent AT-401716-B (AT)
Title: Drawer with closing devices
IPC: A47B88/16
Filed: 1990-12-14
Granted: 1996-11-25
Abstract: The invention relates to a drawer, there being provided on both sides of the drawer a withdrawal rail 13 fixed to the drawer and a load bearing rail 2 fixed to a cabinet carcass, and load-transmitting running rollers or the like being mounted between the rails 2, 13. Two closing devices 1 are provided, each of which comprises a tilting segment 3 which is mounted on the carcass side and subject to the action of a spring, and a driver pin 5 on the drawer side. The tilting segments 3 can be displaced in the withdrawal direction of the drawer and are arranged offset in relation to each other, so that when the drawer is pushed in, one tilting segment 3 after the other acts on the driver pin 5 and only at the end of the pushing-in movement is the drawer pulled into the cabinet carcass by both closing devices 1 together. In order that uniform running of the drawer is ensured, the distance by which the tilting segments 3 are offset is shorter than the guide path 4 of one of the tilting segments 3. <IMAGE>
Patent AT-392995-B (AT)
IPC: B65G7/12
Filed: 1989-12-01
Granted: 1991-07-25
Abstract: The apparatus is used to lift hollow building blocks. L-shaped grippers (1, 2) lying in one plane are provided in pairs, the legs (3) of which are directed downwards and the horizontal legs (4) of which are mutually facing. Provided at the ends of the mutually facing legs (4) are self-locking threads (5), the thread of one leg being a right-hand thread and the thread of the other leg being a left-hand thread. These threads (5) are received by mutually aligned threaded bores (6) of a sleeve (7). This sleeve (7) has a handle (8) projecting laterally at right angles relative to the axis of the aligned threaded bores (6). (Fig. 1). <IMAGE>
Patent AT-405646-B (AT)
Title: Process for the preparation of 3,4-diaryl-5- isoxazolylacetic acid derivatives
Inventor: EICHINGER KARL
IPC: C07D261/08
Filed: 1994-10-28
Granted: 1999-10-25
Abstract: A description of a novel process for the preparation of 3,4-diaryl-5-isoxazolylacetic acid derivatives of the general formula (I) or of a pharmaceutically acceptable salt thereof, in which R1, R2, R3 and R4 are identical or different and are each hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, where "lower" indicates C1 to C4, Ar1 and Ar2 are identical or different and each are phenyl or naphthyl substituted by R1 and R2 or R3 and R4, characterized in that a compound of the general formula (II) in which R1, R2, R3, R4, Ar1 and Ar2 have the abovementioned meanings, is reacted with a 3,3-dialkoxyacrylic acid derivative of the general formula (III), in which R5 and R6 are identical or different and are each a lower alkyl group with C1 to C4, and R7 is a protective group for the carboxyl group, for example a lower (C1-C4)alkyl, benzyl, nitrobenzyl or tert- butyl ester group, and the protective group is subsequently removed, resulting in a compound of the abovementioned general formula (I) which is converted where appropriate into a pharmaceutically acceptable salt thereof. <IMAGE>
Patent DK-165062-B (DK)
Inventor: CAPUTO CARMELO
IPC: F02D19/12
Filed: 1988-03-02
Abstract: Device for the injection in internal combustion engines of combustible emulsions with a readily variable ratio, constituted by a hydrocarbon phase and a component poorly miscible with it, which comprises a positive-displacement pump (10) driven by a portion of the delivery of the injection pump (1) fed with the hydrocarbon phase, said positive-displacement pump (10) carrying out the pumping of the other component of the emulsion; the two components of the emulsion are combined (9), (12) in the injector (8), which incorporates a static emulsifying device upstream the same injector.
Patent DK-158342-B (DK)
Inventor: SPARKS DAVID JOHN
IPC: B67D7/04
Filed: 1983-06-30
Abstract: A liquid dispensing system comprises a supply of liquid (121), a pump (101), a meter (161) and a plurality of dispensing points or stations, (181) each controlled by a solenoid valve (201). A control box (281) monitors the meter and controls by electronic apparatus which station is enabled (that is, which solenoid valve (201) is opened) and displays on a display (261) provided a reading derived from the meter. In one embodiment, selection of a station (181) is effected at the control box but the invention also provides electronic apparatus enabling selection to be effected at each station. The invention does away with the need for a meter at each station and finds application in the dispensing of oil or the like in garage workshops.
Patent FI-62295-B (FI)
Inventor: KRAEMER WOLFGANG
IPC: C07D233/60
Filed: 1979-09-26
Granted: 1982-08-31
Abstract: 1. A-zolyl-1-fluorophenoxy-butane derivatives of the general formula see diagramm : EP0009707,P10,F1  in which A represents a keto group or a CH(OH) group, B represents a nitrogen atom or a CH group and Y represents chlorine or bromine, and their physiologically acceptable salts.
Patent FI-65960-B (FI)
Inventor: HAMMERSCHMIDT WINRICH BERNHARD
IPC: B65B55/00
Filed: 1980-07-30
Granted: 1984-04-30
Abstract: A process and apparatus for providing the surface of margarine and similar pasty products with small cavities prior to bringing said surface into contact with smooth packaging material for decreasing the adherence of said packaging material to said surface. Embossing by directing gas jets onto said surface is preferred, although imprinting with a die is possible as well. The apparatus for putting the process into practice comprises means (11) for making small cavities in the surface (4) of the product. Preferred embodiments of said means are a hollow die (11) with a plurality of nozzle-like openings (12) or a die having a plurality of profilings.