baber/WOPTO huggingface dataset:
Patent DE-69735596-D1 (DE)
Inventor: PONATH D
IPC: C12P21/08
Filed: 1997-08-06
Granted: 2006-05-18
Abstract: The present invention relates to humanized immunoglobulins having binding specificity for ±4²7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human ±4²7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody. The present invention further relates to a humanized immunoglobulin light chain or heavy chain, isolated nucleic acids comprising a sequence which encodes a humanized immunoglobulin or immunoglobulin chain of the present invention (e.g., a single chain antibody), constructs comprising a nucleic acid of the present invention, and host cells comprising a nucleic acid of the present invention useful in a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in diagnostic and therapeutic applications in humans, for example to control lymphocyte infiltration (including recruitment and/or accumulation) to mucosal tissue.
Patent DE-69739278-D1 (DE)
Inventor: CUNNINGHAM DAVID D
IPC: A61B5/145
Filed: 1997-12-04
Granted: 2009-04-09
Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing. In a further aspect of the invention, a pneumatic lancing assembly is provided. The pneumatic lancing assembly uses differential gas pressure to thrust a lancer into skin tissue. In another aspect of this invention, an article is provided for an article capable of both collecting blood and detecting an analyte in that blood. The article, which contains an appropriate detection element for determining the amount of analyte in the blood, can be used in conjunction with a meter that measures the signal generated by the detection element of the article.
Patent DE-69800393-D1 (DE)
Inventor: MORGAN CLIVE
IPC: A47G9/02
Filed: 1998-01-14
Granted: 2000-12-21
Abstract: A duvet cover (3) comprises a base sheet portion (5) intending to lie under the duvet, and a top portion (7) intended to lie over the top of a duvet and attached to or made integrally with the base portion (5) so as to be joined thereto along one edge (9). Attachment means (11, 13) are provided for attaching the remaining sides of the base and top portions (5, 7) together along the other three sides.
Patent DE-69800496-D1 (DE)
Inventor: CORNIA ENRICO MARIA
IPC: B60D1/14
Filed: 1998-04-07
Granted: 2001-03-01
Abstract: A lower arm for a three-point coupling of the type used, for example, on agricultural tractors for the connection of agricultural implements and the like, comprises a coupling device (7) for an implement and a bar (2) connected rigidly to the coupling device. The upper wall of the bar has a ridge or projection (14) in the vicinity of the connection (11) with the engagement device (7). In one particular embodiment at least one recess or dent (12) is formed in the vicinity of the connection (11) with the engagement device (7), the ridge or projection (14) being defined by the portion of the recess or dent (12) facing the connection region. <IMAGE>
Patent DE-69808153-D1 (DE)
Inventor: CASENOVE YVES
IPC: C06B31/28
Filed: 1998-10-23
Granted: 2002-10-24
Abstract: The present invention relates to preparation of ammonium nitrate (AN) products having improved thermal stability, products thereof and their use in explosives or fertilizers. A solid drying agent is mechanically mixed with AN-particles and said agent has water binding capacity, is compatible with the end use of the AN product and has a critical relative water vapour pressure above the agent being less than said pressure above the AN product. Preferred drying agent will be AN-particles comprising magnesium nitrate. The drying agent may have a water binding capacity being equal to or larger than the content of free water in the AN-particles.
Patent DE-69813263-D1 (DE)
Inventor: CARNIATO DENIS
IPC: A61K31/496
Filed: 1998-09-23
Granted: 2003-05-15
Abstract: Compounds of the formulawherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss of bone matrix.
Patent DE-69813875-D1 (DE)
Inventor: RAMALINGAM BALASUBRAMANIAM
IPC: C09J175/00
Filed: 1998-12-04
Granted: 2003-05-28
Abstract: Waterborne polyurethanes possessing urea-urethane linkages that are not separated by any intervening carbon atoms may be obtained by using hydroxylamine as a chain extender. Isocyanate-terminated prepolymer possessing ionized or easily ionizable groups is reacted with NH2OH to form a polyurethane possessing urea-urethane linkages corresponding to the formula: The waterborne polyurethanes are useful in adhesive, coating and ink formulations and in the flexible package industry.
Patent DE-69815807-D1 (DE)
Inventor: STRAIT A
IPC: D04H1/4226
Filed: 1998-03-20
Granted: 2003-07-31
Abstract: A system for making densified glass fiber pellets from chopped segments of multi-filament glass strand is described. The densified pellets may be advantageously produced by hydrating chopped glass strands and then pelletizing them by tumbling in a rotary drum, and densifying the resulting pellets by tumbling in a rotating zig-zag or undulating tube for a period of time sufficient to increase their density but insufficient to degrade the fibers to a point where composite articles formed from such pellets have lower tensile or impact strengths than comparable composite articles formed from unpelletized strand segments.
Patent DE-69825926-D1 (DE)
Inventor: VERCAUTEREN RONNY
IPC: C13K7/00
Filed: 1998-02-18
Granted: 2004-10-07
Abstract: The present invention describes a simple and inexpensive purification method for acid-stable fungal alpha-amylase wherein the alpha-amylase is obtained without significant loss of enzyme activity. The purified acid-stable alpha-amylase which is obtained is substantially free from glucoamylase. The method for obtaining an acid-stable alpha-amylase comprises the steps of   adjusting the pH of the enzyme containing solution to a value between 1 and 8, heating the solution to a temperature and for a time sufficient to inactivate glucoamylase,   removing the denatured glucoamylase. The purified acid-stable alpha-amylase is used for the conversion of starch. The purified alpha-amylase is also used in an immobilized form.
Patent DE-69827778-D1 (DE)
Inventor: PETER-HOBLYN D
IPC: C10L10/06
Filed: 1998-01-30
Granted: 2004-12-30
Abstract: Gasoline engines equipped with three-way catalysts emit less NOx, hydrocarbons and carbon monoxide when operated on fuels containing a bimetallic catalyst comprising rhodium acetylacetonate and a fuel-soluble platinum compound such as diphenyl cyclooctadiene platinum(II) or platinum acetyl acetonate. The total metals in the additive will be dosed at a concentration of less than about 2 ppm (milligrams of metal to liter of gasoline) based on the amount of gasoline burned in the engine. Preferred dosages will be from about 0.15 to about 1.5 ppm, with a ratio of platinum to rhodium of from about 3:1 to about 15:1.
Patent DE-69828876-D1 (DE)
Inventor: KIMCHI ADI
IPC: A61P25/28
Filed: 1998-03-03
Granted: 2005-03-10
Abstract: DNA molecules comprising a nucleic acid sequence expressed in cells, the expression product of which is involved in programmed cell death. Also disclosed are methods of therapeutic treatment using the DNA molecules and their expression products, and pharmaceutical compositions containing them.
Patent DE-69831854-D1 (DE)
Inventor: BASSETT WALT H
IPC: B32B17/04
Filed: 1998-11-26
Granted: 2006-02-23
Abstract: A filled glass mat thermoplastic (GMT) composite material having a polyolefin, glass fibers and a filler. The filled GMT composite material exhibits mechanical properties that are similar to or significantly improved over non-filled GMT composite materials. The preferred polyolefins include polypropylene, polyethylene, polymethylpentene, and copolymer blends thereof. The glass fibers are greater than 1/4 inch (6.4 mm) in length and are preferably at least 1/2 inch (12.7 mm) in length. The glass fibers may be a continuous glass mat, such as unidirectional or random mats and woven or non-woven mats, or chopped fibers. The filler is selected from mineral, synthetic or plant sources and is preferably selected from mica, talc, calcium carbonate and barium sulphate. The filled GMT composite material is less expensive to produce than similar non-filled GMT composite materials, does not sacrifice impact strength and tensile strength properties and can be used for automotive bumper beams.
Patent DE-69834330-D1 (DE)
Inventor: TRIEBEL FREDERIQUE
IPC: A61K39/39
Filed: 1998-07-23
Granted: 2006-06-01
Abstract: The present invention concerns a use of a MHC class II ligand, such as CD4 and LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune response, as well as the use of LAG-3 in cancer-immunotherapy. The invention also concerns a pharmaceutical composition comprising an effective amount of an antigen able to induce an antigen-specific immune response together with an effective amount of MHC class II ligand wherein said MHC class II ligand is present as an adjuvant-like agent.
Patent DE-69837087-D1 (DE)
Inventor: LENNON J
IPC: G01N30/00
Filed: 1998-04-15
Granted: 2007-03-29
Abstract: An assay device for detection or determination of an analyte in a sample uses either removably attachable components or hinged panels to provide greater flexibility and reduce manufacturing and storage costs. In one embodiment of the device, the device comprises: (1) a first opposable component including:(a) a first panel; (b) a second panel mounted on the first panel generally parallel to the first panel with space between the first and second panel, the second panel having an opening forming a first receptacle for a sample collection device; and (c) a second receptacle for a test strip formed by the first panel and the second panel; and (2) a second opposable component hingedly attached to the first opposable component. In this device, the first and second opposable components can be brought into operable contact so that fluid is expressed from the sample collection device and applied to the test strip for detection or determination of an analyte by a test performed on the test strip. Other embodiments of devices are included, as well as test kits and method of use of the devices.
Patent DE-69839430-D1 (DE)
Inventor: ASHKENAZI AVI
IPC: A61P37/02
Filed: 1998-11-20
Granted: 2008-06-12
Abstract: A33 related antigens PRO301, PRO362 and PRO245, are new. Independent claims are also included for the following: (1) a nucleic acid comprising DNA having at least 95% sequence identity to: (a) a DNA molecule encoding PRO301 comprising amino acids 28-235 of a 299 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209432 (designated DNA40628-1216); or (c) the complement of DNA in (a); (2) a nucleic acid comprising DNA having at least 80% sequence identity to: (a) a DNA molecule encoding PRO362 comprising amino acids 1-321 or 1-X (X = any of residues 271-280) of a 321 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209620 (designated DNA45416-1251); or (c) the complement of DNA in (a); (3) production of PRO301, PRO362 or PRO245; isolated PRO301 comprising residues 28-235 of the 299 residue sequence; (4) isolated PRO362 comprising residues 1-229 or 1-X (X = 271-280) of the 321 residue sequence; (5) an isolated antibody which binds PRO301 or PRO362; (6) treating an inflammatory disease by administering a therapeutically effective amount of a PRO301, PRO362 or PRO245 antagonist or fragment; determining the presence of PRO301, PRO362 or PRO245; and (7) diagnosis of an inflammatory disease or tumor, by detecting the level of PRO301, PRO362 or PRO245 gene expression. ACTIVITY : Cytostatic; Anti-inflammatory. MECHANISM OF ACTION : Antagonist.
Patent DE-69841650-D1 (DE)
Inventor: SMITH KURT R
IPC: G06F17/30
Filed: 1998-04-09
Granted: 2010-06-17
Abstract: An apparatus and method for producing composite data by a server computer involves deforming a template creating a mapping relationship between co-registered data and subject data, filtering the co-registered data, and mapping this filtered co-registered data according to the mapping data. A client computer requests the composite data from the server computer and transmits the subject data to the server computer. The client presents the received composite data to an operator and monitors the operators use of the composite data.
Patent DE-69902534-D1 (DE)
Inventor: SCHIRMANN JEAN-PIERRE
IPC: C07C45/42
Filed: 1999-05-06
Granted: 2002-09-19
Abstract: The invention concerns a method for making hydrazine hydrate which consists in hydrolyzing methyl ethyl ketone azine to obtain hydrazine hydrate and methyl ethyl ketone, characterised in that it consists in purging heterocyclic compounds of the pyrazoline family to prevent coloration of the hydrazine hydrate.
Patent DE-69906748-D1 (DE)
Inventor: KRISTIANSEN BJOERN
IPC: A61F13/511
Filed: 1999-07-01
Granted: 2003-05-15
Abstract: The invention relates to a liquid-permeable surface material for absorbent disposable products such as nappies, incontinence pads, sanitary towels, panty liners or the like. The invention also relates to a method for the manufacture of such a surface material and an absorbent disposable product which utilizes such a surface material. The liquid-permeable surface material (21) comprises a material structure (22) in micro-scale with many pores (23, 23', 23''). Each of the many pores has, in the plane of the surface material, a first pore cross section dimension (2a), a second pore cross section dimension (2b), a pore cross section area and a pore circumference, where the second pore cross section dimension (2b) is essentially at right angles to the first pore cross section dimension (2a). According to the invention, before use in an absorbent product the liquid-permeable surface material (21) has been subjected to a stretching process in order to obtain a low pressure drop when liquid passes through. As a result of the stretching process the first pore cross section dimension (2a) has become considerably larger than the second pore cross section dimension (2b).
Patent DE-69906771-D1 (DE)
Inventor: HILDER MATTHEW
IPC: B01F7/00
Filed: 1999-10-19
Granted: 2003-05-15
Abstract: A single screw extruder comprises a mixer associated with the screw, and comprising a rotor driven by the screw and a stator, the rotor and the stator each carrying mutually facing interengaging rings of teeth whereby the material is urged outwardly from the screw along a first tortuous mixing path, and then returned inwardly to the screw along a second tortuous mixing path, with the teeth extending axially, or generally so, with respect to the longitudinal axis of the screw. The invention also includes a mixer comprising a cylindrical stator chamber having opposed, radially extending faces provided with axially projecting, radially spaced-apart rings made up of alternating teeth and ridges, a rotor rotatably fitted within the stator and provided on its opposite side faces with axially projecting, radially spaced-apart rings of alternating teeth and ridges with the rotor and stator rings interengaging with both radial and axial clearance so as to define a tortuous material flow path.
Patent DE-69916868-D1 (DE)
Inventor: KARLSSON TOMAS
IPC: F01P7/14
Filed: 1999-10-06
Granted: 2004-06-03
Abstract: A modular valve combination system for vehicle fluid heating systems containing water type fluids comprises a number of valve units (1, 1', 1''). Each valve unit is associated with a stackable collector housing (2) with first and second through bores (3, 4). When stacked said bores form a fluid supply collector (3) and a fluid return collector (4) respectively. Each valve unit (1, 1', 1'') comprises a primary valve means (7, 7', 7''). At least one of the valve units (1, 1', 1'') is connected to its associated stackable collector housing (2) so that its primary valve means (7, 7', 7'') selectively can allow a flow either from fluid supply collector (3) to an external circuit, which is then returned to the fluid return collector (4) or into the fluid return collector (4) from an external circuit, which originates from the fluid supply collector (3). At least one of the stackable collector housings (2) display a bypass-channel (9, 9'), connecting the fluid supply collector (3) with the fluid return collector (4). The valve unit associated with said collector housing (2) comprises a secondary valve means (10, 10') for allowing a bypass flow through the bypass-channel (9, 9'), when the primary valve means (7, 7', 7'') is closed and vice versa.
Patent DE-69926499-D1 (DE)
Inventor: DELRUE M
IPC: A23B9/00
Filed: 1999-05-14
Granted: 2005-09-08
Abstract: A particulate food product is indirectly heated to at least about 170 DEG  after steam is directly injected onto the particulate food product to provide a moist environment and surface moisture on the particulate food product. The indirect heating is continued for a time and temperature to reduce the microbial contamination of the particulate cereal and/or legume products by an amount of at least log 2 without the loss of the functional properties.
Patent DE-69926790-D1 (DE)
Inventor: GAN JOSEPH
IPC: H05K3/38
Filed: 1999-12-10
Granted: 2005-09-22
Abstract: A resin composition including from about 1 to about 100 weight percent of a thermoplastic oxazolidone ring-containing compound having a molecular weight of at least 5000, which is the reaction product of:a) from about 20 to about 43 weight percent, based on the polyepoxide and polyisocyanate reactants, of a polyisocyanate having an isocyanate-functionality of from about 1.8 to about 2.2;b) from about 80 to about 57 weight percent, based on the polyepoxide and polyisocyanate reactants, of a polyepoxide having an epoxide functionality of from about 1.8 to about 2.2; and optionally,c) a chain extender.The resin composition is used as an adhesive to adhere a copper foil to a prepreg or a laminate, with improved peel strength and Tg.
Patent DE-69942101-D1 (DE)
Inventor: REZAI EBRAHIM
IPC: D04H1/544
Filed: 1999-09-28
Granted: 2010-04-15
Abstract: The present invention is directed to an elastic laminate which is elastically extensible in at least one direction. The elastic laminate (70) includes an elastomeric material (124) having a first surface (150) and a second surface (152) opposing the first surface. The elastomeric material includes a polystyrene thermoplastic elastomer. The elastic laminate further includes a first nonwoven layer (122) including component fibers which include a polyester. The elastomeric material (124) is bonded to the first nonwoven layer (122) through a continuous heat/pressure bond which is formed by application of a bonding temperature which is lower than the melting point of the polyester. The present invention is also directed to a disposable garment employing such an elastic laminate.
Patent DE-502004002147-D1 (DE)
Inventor: LENZ BERNHARD
IPC: F16B7/18
Filed: 2004-06-03
Abstract: A building block system is employed for the construction or machine main support frames or for the construction of protective cages around such machines. The system consists of extruded aluminum profiled with an essentially rectangular cross-sectional profile with four overhanging grooves (19). The system further includes a right angles profile link fitting.
Patent DE-502004005136-D1 (DE)
Inventor: FROHNE CHRISTIAN DR
IPC: F16L9/00
Filed: 2004-06-09
Abstract: Process for continuous preparation of a long weld seam metal tube in which a metal band from a metal band store is formed in a profiling device similar to a slit tube, the slit tube is arc welded at the edges under a shielding gas, the welding set having two welding electrodes, the tips of which are directed to the same weld point. To change an electrode an auxiliary arc is ignited in a replacement unit and welding is continued with this unit.
Patent DE-502004008858-D1 (DE)
Inventor: KLOCKMANN OLIVER DR
IPC: C08L21/00
Filed: 2004-10-23
Abstract: Rubber mixtures comprise rubber, a filler, a sulfur-containing organosilane (I), a thiuram accelerator and a nitrogen-containing coactivator. Rubber mixtures comprise rubber, a filler, a sulfur-containing organosilane of formula (I), a thiuram accelerator and a nitrogen-containing coactivator. [Image] R 1>1-12C alkyl or OR 4>; R 4>1-30C alkyl, alkenyl, aryl, aralkyl or Si(R 5>) 3; R 5>1-30C alkyl or alkenyl; R 2>a divalent 1-30C aliphatic and/or aromatic hydrocarbon group; R 3>H, CN, COR 6>, CO or P=S; R 6>1-30C alkyl, alkenyl, aryl or aralkyl; q : 1-3.
Patent DE-502004009920-D1 (DE)
Inventor: ZILLMER MICHAEL
IPC: B60K6/48
Filed: 2004-12-04
Abstract: The operating process involves setting the ignition advance during the reduction of drive torque by reducing the cylinder filling and/or closing the throttle to depend on the instantaneous cylinder filling, or on the setting of the throttle, to a value which, for this simultaneous filling or throttle setting, produces a more raw less optimal efficiency of the internal combustion engine.
Patent DE-502005003588-D1 (DE)
Inventor: STEBANI UWE
IPC: G03F7/18
Filed: 2005-10-12
Abstract: Processes comprising providing a layer composite comprising a layer of photopolymerizable material and a removable substrate film disposed on one side of the layer of photopolymerizable material, wherein the photopolymerizable material comprises an elastomeric binder, an ethylenically unsaturated monomer and a photoinitiator; and (a) miter-cutting two edges of the layer composite to be joined, to form two miter-cut ends; (b) providing a hollow cylinder on a rotatably mounted support cylinder, wherein the hollow cylinder has an outer surface and is in a temporarily locked position relative to the support cylinder; (c) applying an adhesion-promoting layer to the outer surface of the hollow cylinder; (d) applying the layer composite to the hollow cylinder bearing the adhesive-promoting layer, wherein the layer composite is disposed on the hollow cylinder such that the removable substrate film faces away from the hollow cylinder and the two miter-cut ends lie substantially one on top of the other, but not overlapping; (e) removing the substrate film from the layer of photopolymerizable material to provide an exposed surface of the layer of photopolymerizable material; (f) contacting the exposed surface of the layer of photopolymerizable material with a rotating calender roll with heating to join the two miter-cut edges and form a processed hollow cylinder, wherein heating comprises a locally-acting heat source moved in an axial direction relative to the hollow cylinder along the entire width of the layer of photopolymerizable material such that the exposed surface is heated; and (g) removing the processed hollow cylinder from the support cylinder.