Patent SG-11201807040W-A (SG)
Title: N,n-dimethyl-3-[[5-(3-methyl-2-oxo-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine oxide as atm (ataxia telangiectasia mutated) kinase modulator for treating cancer
Inventor: BARLAAM BERNARD
IPC: C07D471/04
Filed: 2017-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11 M1111101110101011111 HO 111110111010111011101110rn I MEV III International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....1 WO 2017/174446 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CO7D 471/04 (2006.01) A61P 35/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 31/437 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/EP2017/057624 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 30 March 2017 (30.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 1605958.6 7 April 2016 (07.04.2016) GB GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 Soder- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, talje (SE). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: BARLAAM, Bernard, Christophe; As LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, traZeneca Alderley Park, Macclesfield Cheshire SK10 4TG SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (GB). PIKE, Kurt, Gordon; AstraZeneca, Darwin Build- GW, KM, ML, MR, NE, SN, TD, TG). ing, Cambridge Science Park Milton Road, Cambridge Declarations under Rule 4.17: Cambridgeshire CB4 OWG (GB). — as to applicant's entitlement to apply for and be a granted (74) Agent: JONES, Teyrnon; ASTRAZENECA INTELLEC- patent (Rule 4.1700) TUAL PROPERTY, Mereside, Alderley Park, Maccles- Published: field Cheshire SK10 4TG (GB). (81) — Designated States (unless otherwise indicated, for every with international search report (Art. 21(3)) kind of national protection available): AE, AG, AL, AM, (54) Title: N,N-DIMETHYL-3-[[5-(3-METHYL-2-0X0-1-TETRAHYDROPYRAN-4-YL-IMIDAZO[4,5-C]QUINOLIN-8-YL)-2- . PYRIDYL]OXY]PROPAN-1-AMINE OXIDE AS ATM (ATAXIA TELANGIECTASIA MUTATED) KINASE MODULATOR FOR TREATING = CANCER O C H 3 H 3 C\" N+ 1 ..-\"*---------'° 0 - 1-1 .4 \ — C H 3 71' 0 10 71' 71' N IN 1-1 IN 1-1 (I) 0 ei (57) : The specification generally relates to the compound of Formula (I), i.e. to N,N-dimethy1-34[5-(3-methy1-2-oxo-l-tet - 0 rahydropyran-4-yl-imidazo[4,5-c]quinolin-8-y1)-2-pyridyl]oxy]propan-l-amine oxide as ATM (ataxia telangiectasia mutated) kinase modulator for treating cancer.