baber/WOPTO huggingface dataset:
Patent MX-2022006626-A (MX)
Title: Therapy for the treatment of cancer.
Inventor: HAGNER PATRICK
IPC: A61K31/5377
Filed: 2020-12-01
Abstract: Provided herein are methods of treating and/or managing cancer, which comprise administering to a patient Compound A, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Additionally, provided herein are methods of treating and/or managing cancer, which comprise administering to a patient Compound A, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, in combination with a second agent selected from the group consisting of an anti-CD20 antibody, an HDAC inhibitor, a proteasome inhibitor, an anti-CD38 antibody, an anti-SLAMF7 antibody, a nuclear export inhibitor, a BCL-2 inhibitor, and an immune checkpoint inhibitor. Also provided herein are combination therapies for treating and/or managing cancer, which further comprise dexamethasone as a third agent.
Patent MX-2022011707-A (MX)
Title: Applications of pi4k inhibitor in intracellular protein misfolding-related diseases and lysosomal storage diseases.
Inventor: HONG FENG
IPC: C07K14/81
Filed: 2021-03-31
Abstract: Provided are uses of a PI4KIIIÎ±-specific inhibitor in preventing or treating intracellular protein misfolding-related diseases, also provided are uses of the PI4KIIIÎ±-specific inhibitor in preventing or treating lysosomal storage diseases.
Patent MX-PA01001144-A (MX)
Title: Inhibition of graft versus host disease.
Inventor: SPANER DAVID ELLIOTT
IPC: A61K35/28
Filed: 1999-07-30
Abstract: The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, extracorporeally, to oxidative stress, in appropriate dosage amounts, such as bubbling a gaseous mixture of ozone and oxygen through a suspension of the T-cells. The process may also include irradiation of the cells with UV light, simultaneously with the application of the oxidative stress. The oxidative stress induces reduced inflammatory cytokine production and a reduced proliferative response in the T-cells.
Patent MX-PA01004017-A (MX)
Title: Pressure regulating tire valve and core.
Inventor: SUMRALL DIRK L
IPC: F16K15/20
Filed: 1999-10-22
Abstract: The present invention is related to air pressure valve stems and gauges. More particularly, this invention relates particularly to a tire stem valve (1) possessing a built-in calibrated air pressure regulator consisting of a spring (5), a moveable disk (7) and a solid disk (8) and an optional integrated air pressure indicator (36).
Patent MX-PA01005734-A (MX)
Title: Multi-wire contact by insulation cut and method to.
Inventor: LAVAL CHUNG LONG SHAN
IPC: H01R4/2425
Filed: 2001-06-07
Abstract: ESTABLISH MULTIPLE HOME TERMINATIONS The present invention discloses a method for placing wire in a groove (18) of a bifurcated contact by insulating contact (10). The wires are placed in the groove alternatively disposed in relation to the direction side to side (A) from the groove. Between the wire and each successive pair of wires at the groove, the established angle between the pair of wires is bigger than the one established by one of the wires in relation to the side to side direction of the groove.
Patent MX-PA01010083-A (MX)
Title: Vacuum cleaner inner bag.
Inventor: EMBREE MICHAEL E
IPC: A47L9/22
Filed: 2000-03-22
Abstract: An apparatus and method for separating particulates from a flow of air and particulates in a vacuum cleaner. In one embodiment, the apparatus includes a removable vacuum cleaner filter (80) having a flange portion (82) with a flange aperture (83). A flexible, porous filter element portion (81) is attached to the flange portion (82) and is elongated along a filter axis. The filter element portion (81) has a generally constant cross-sectional area when intersected by a plane generally perpendicular to the filter axis (85).
Patent MX-PA01013066-A (MX)
Title: Wet-stick adhesives, articles, and methods.
Inventor: LUCAST DONALD H
IPC: C09J171/02
Filed: 1999-06-18
Abstract: A wet-stick pressure-sensitive adhesive is provided wherein the pressure-sensitive adhesive comprises: at least one copolymerized monoethylenically unsaturated (meth)acrylic acid ester monomer, wherein the (meth)acrylic acid ester monomer, when homopolymerized, has a Tg of less than about 10 °C; at least one copolymerized hydrophilic acidic comonomer; and at least one nonreactive copolymer comprising at least two copolymerized alkylene oxides, at least one of which is hydrophobic and at least one of which is hydrophilic.
Patent MX-PA02001824-A (MX)
Title: Refastenable absorbent article.
Inventor: NEFETARI EDRIS BORDAIN
IPC: A61F13/56
Filed: 2000-08-23
Abstract: An absorbent article is disclosed having a refastenable mechanism. The absorbent article has a front portion, a back portion and a crotch portion. The crotch portion connects the front portion to the back portion. The back portion has a first end, a second end and first and second side edges. The back portion is divided into a first section and a second section. The first section is extendable in at least one direction and has a length L2 measured perpendicularly from the first end of the back portion to a line drawn parallel thereto. The second section has a length L3 measured perpendicularly from the second end of the back portion to the line drawn parallel to the first end whereby a ratio L2 L3 is established which ranges from between about 0.1 to about 2. First and second fasteners are positioned and secured adjacent to one of the first and second side edges of the back portion and are secured thereto. The absorbent article further includes an absorbent secured to at least one of said front, back or crotch portions. Each of the first and second fasteners are releasably attached to the front portion to form a pant like article having a waist opening and a pair of leg openings.
Patent MX-PA02002217-A (MX)
Title: Vehicle stabilizing system having pivotal support.
Inventor: ROBERT R AMBROGI
IPC: A61G5/04
Filed: 2000-08-29
Abstract: A balancing vehicle that supports a rider on a support such as a seat in a such a manner as to allow the position of the center of gravity of the vehicle to be varied by motion of the support. Motion of the support additionally provides for control of a drive that propels the vehicle in a manner responsive to the position of the center of gravity. The vehicle is thus capable of control by leaning of a seated rider.
Patent MX-PA02004386-A (MX)
Title: Coating for textiles for ink jet printing.
Inventor: ZELAZOSKI LEONARD EUGENE
IPC: D06M11/76
Filed: 2000-10-31
Abstract: A method of producing a printed substrate so as to improve the adhesion, colorfastness and washfastness of either reactive or acid dye-based ink jet inks printed onto the substrate, the method includes the steps of providing a substrate, treating the substrate with an aqueous coating formulation comprising a cationic polymer or copolymer, a fabric softener, treating the substrate of step with an imbibing aqueous solution of either urea, and an ingredient selected from sodium bicarbonate, sodium carbonate or combinations thereof, or ammonium sulfate, drying the substrate, printing on the substrate with either an acid or reactive dye-based ink, depending on the coating and post treating the printed substrate.
Patent MX-PA02004453-A (MX)
Title: Reaccessible medical needle safety devices and methods.
Inventor: MARK FERGUSON
IPC: A61M5/158
Filed: 2000-10-31
Abstract: A retractable and extendable medical needle protective shield (50, 50 ) which provides for accessing and reaccessing a medical needle (40) and associated sharpened needle tip (100) and recovering the needle (40) and tip (100) for safety between accesses. The shield (50, 50 ) includes a needle guide (130, 138) which assures the needle tip (100) is untouched by any part of the shield (50, 50 ) as the shield (50, 50 ) is displaced to cover and uncover the needle (40). A releasible latch (148, 162) is provided to guard against inadvertent removal of the protective shield (50, 50 ) between accesses. An unreleasible latch (182, 190) is also provided to secure the shield (50, 50 ) relative to the latch (182, 190) preparatory to final disposal.
Patent MX-PA02005795-A (MX)
Title: Glassware forming mold and method of manufacture.
Inventor: DAVID L LEWIS
IPC: C22C37/10
Filed: 2002-06-11
Abstract: Thermal conductivity of glassware forming blank molds and blow molds of Ni-Resist ductile iron is selectively controlled by formation of compacted graphite in the mold microstructure during preparation of the melt and casting of the mold bodies. Specifically, with a Type D5 Ni-Resist ductile iron according to ASTM-A439-84, compacted graphite is selectively formed in the cast microstructure of the mold body by reducing the magnesium and sulphur concentrations in the iron composition to the range of 0.01 to 0.04 wt % magnesium and 0.00 to 0.01 wt % sulphur, and adding titanium to the iron composition in the range of 0.10 to 0.25 wt % titanium. Whereas formation of compacted graphite in the cast microstructure is normally considered to be undesirable for glassware forming molds, it has been found that formation of a small but appreciable amount of graphite provides the opportunity selectively to tailor the thermal conductivity characteristics of the mold body.
Patent MX-PA02007628-A (MX)
Title: Composite protective coating for metal surfaces.
Inventor: DANNER MARK CARL
IPC: C09J7/38
Filed: 2001-01-29
Abstract: Prepare a composite protective coating for metal substrates such as steel used in fabricating metal pipe or conduit. The coating, when applied to a flat metal surface, retains its bond to the metal through cold forming processes such as those used in making ribbed steel pipe. The coating resembles a sandwich of a reinforcing material layer between two adhesive films.
Patent MX-PA02008179-A (MX)
Title: Process for the preparation of milk powder.
Inventor: BODENSTAB STEFAN
IPC: A23C1/05
Filed: 2001-02-08
Abstract: A process for the production of a fat containing milk powder, comprising preparing a liquid milk, feeding the prepared liquid milk into an evaporator having at least one stage to obtain a pre concentrate, homogenising the pre concentrate, further evaporating the pre concentrate in an evaporator having at least one stage to obtain a concentrate having a total solids content of at least 50 %, and then spray drying the concentrate.
Patent MX-PA02009871-A (MX)
Title: Pipette with simplified disassembly.
Inventor: VIOT FRANCCEDIL
IPC: B01L3/02
Filed: 2001-04-09
Abstract: The invention concerns a pipette comprising a hub (4), a plunger (8) slidably mobile in the hub and a joint (36) in contact with the hub and the plunger to provide a sealing assembly. The hub comprises two parts (4a, 4b) detachably secured to each other between which the joint (36) is interposed.
Patent MX-PA03001680-A (MX)
Title: Packaging of positive-strand rna virus replicon particles.
Inventor: GANGOLLI SEEMA S
IPC: A61K39/00
Filed: 2001-08-28
Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
Patent MX-PA03003157-A (MX)
Title: N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing said trimeres.
Inventor: MERINO FERNANDEZ JAIME M
IPC: A61P25/06
Filed: 2001-10-05
Abstract: The invention relates to N-alkylglycine trimeres (I), wherein R1, R2 and R3, independent of one another, are chosen fromamongst cyclopropyl, sec-butyl, 2-methoxyethyl, 3-methylbutyl, cyclohexyl, 2-(N-pyrrolidinyl)ethyl, 2-(methylcarbonylamino)ethyl, 3-(2-oxo-N-pyrrolidinyl)propyl, 2-(2pyridyl)ethyl, 2-phenylethyl, 1-(2-tetrahydrofuryl)methyl, 2-(N-imidazolyl)ethyl, 2-(4-methoxyphenyl)ethyl, 2-(3,4-dimethoxyphenyl)ethyl, 2-(2,4-dichlorophenyl)ethyl, 2-[2-N-methyl)pyrrolidinyl]ethyl, 2-(4- aminosulfonylphenyl)ethyl, 2-(morpholine)ethyl, 3-N,n, -diethylamino)propyl, 3,3-diphenyl-propyl, 3-(N,N-dimethylamino)propyl, and 2-(N, N-dietylamino)ethyl, their stereoisomeric forms and their mixtures, which are capable of blocking L-glutamate receptors and are useful for treating disorders mediated by said receptors.
Patent MX-PA03004450-A (MX)
Title: Tricyclic compounds and their uses.
Inventor: KLEIN J PETER
IPC: A61P3/10
Filed: 2001-11-09
Abstract: Novel tricyclic compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling.
Patent MX-PA03005343-A (MX)
Title: Liquid antacid compositions.
Inventor: DONALD L HANSENMAYER
IPC: A61K9/00
Filed: 2003-06-13
Abstract: Liquid antacid preparations comprising: a) an active acid neutralizing compound selected from the group consisting of calcium-containing compounds, aluminum-containing compounds, magnesium-containing compounds, and mixtures thereof; and b) an antimicrobial adjuvant selected from the group consisting of propylene glycol in an amount greater than 2 weight percent and less than 15 weight percent, glycerin in an amount from about 15 to about 20 weight percent, and combinations of propylene glycol in an amount from about 3 to about 10 weight percent with glycerin in an amount from about 3 to about 10 weight percent based on the total weight of the preparation are provided.
Patent MX-PA03007605-A (MX)
Title: Footswitch.
Inventor: PETERSON ROBERT H
IPC: G05G1/30
Filed: 2003-08-25
Abstract: A footswitch having an adjustable treadle and switch placements, thereby helping to make the footswitch ergonomically more correct for a variety of users.
Patent MX-PA03010210-A (MX)
Title: Peptides and related molecules that bind to tall-1.
Inventor: HSU HAILING
IPC: A61K38/08
Filed: 2002-05-13
Abstract: The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae a1a2a3CDa6La8a9a10Ca12a13a14 (SEQ.ID.NO:100), b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ.ID.NO:104) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ.ID.NO:105) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ.ID.NO:106) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ.ID.NO:107) f1f2f3Kf5Df7Lf9f10Qf12f13f14 (SEQ.ID NO:109) wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
Patent MX-PA04002595-A (MX)
Title: System and method for producing concentrated food products with fractionation concentration.
Inventor: JORGE K SUCCAR
IPC: A23L11/30
Filed: 2002-09-19
Abstract: An improved processing method and system for producing tomato paste and other food products affected by viscosity. Tomatoes are processed into tomato juice. The juice is provided to a decanter that separates or fractionates the juice into two portions - a thicker, more viscous cake portion and a thinner, less viscous serum portion. The serum portion is concentrated by removing a portion of water using an evaporator such as a thin film or juice evaporator. The cake portion can be concentrated if necessary with a drier. The serum and cake portions are recombined to produce a tomato paste having improved color, texture, flavor and nutrition.
Patent MX-PA04003953-A (MX)
Title: Method and device for the delivery of a substance.
Inventor: JOHN A MIKSZTA
IPC: A61K/
Filed: 2002-10-29
Abstract: An abrasion device and method for delivery of substances into the skin comprises a microabrader for delivering a substance into the skin having a base with an abrading facet, to which an abrading surface having an arrangement of microprotrusions that have at least one scraping edge is attached, mounted, or integral with and a handle attachment facet, to which a handle or other grasping device is attached or mounted.
Patent MX-PA04006770-A (MX)
Title: Integrated processing of natural gas into liquid products.
Inventor: JEFFREY H SAWCHUK
IPC: C01B3/50
Filed: 2002-12-11
Abstract: An integrated process for producing LNG and GTL products is provided comprising cooling natural gas (1) in at least one cooling step (2) so as to provide a cooled natural gas stream; processing the cooled natural gas stream (8) in at least two expansion/separation cycles, each expansion/separation cycle comprising the Substeps of (a) isentropically or isenthalpically expanding (9, 21) at least a portion of the cooled natural gas steam for producing a natural gas vapor component (13 A, B) and a LNG component (19, 24), (b) separating at least a portion of the natural gas vapor component from the LNG component, and (c) repeating substeps (a) through (b) wherein at least a portion of the LNG component from the previous expansion/separation cycle is directed to each successive Substep (a) and wherein the final LNG product (24) is the LNG component after the final separating step and is substantially liquid at substantially atmospheric pressure; and converting at least a portion of one or more of the expansion/separation cycle natural gas vapor components (13 A, B) into a GTL product.
Patent MX-PA04007935-A (MX)
Title: Stabilized synthetic immunogen delivery system.
Inventor: KENNETH K SOKOLL
IPC: A61P33/00
Filed: 2003-02-14
Abstract: The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w/o-emulsions, as a suspension in combination with a mineral salt suspension or with an in-situ gelling polymer for the efficient delivery of an immunogen to the cells of the immune system of a subject following parenteral administration, to produce an immune response which may also be a protective immune response.
Patent MX-PA04008625-A (MX)
Title: Systems for regulating voltage to an electrical resistance igniter.
Inventor: RALSON JAMES M
IPC: F23Q7/22
Filed: 2003-02-25
Abstract: Systems and methods for energizing an electrical resistance igniter are disclosed. The systems and methods determine the line voltage into the system and control the voltage being applied to the electrical resistance igniters so a first voltage is applied initially and for a time period and thereafter a second voltage is applied, the second voltage being the operating voltage for the igniter. The systems and methods decrease the amount of time required to heat-up the electrical resistance igniter to a temperature sufficient to ignite the gas while regulating the output voltage being delivered to the igniters to prevent over voltage damage to the igniters.
Patent MX-PA04009527-A (MX)
Title: Surgical stapling instrument having multistroke firing incorporating a traction-biased ratcheting mechanism.
Inventor: SWAYZE JEFFREY S
IPC: A61B17/072
Filed: 2004-09-29
Abstract: A surgical stapling and severing instrument particularly suited to endoscopic procedures incorporates a handle that produces separate closing and firing motions to actuate an end effector. In particular, the handle produces multiple firing strokes in order to reduce the required amount of force required to fire (i.e., staple and sever) the end effector. A linked transmission reduces the required handle longitudinal length, yet achieves a rigid, strong configuration when straightened for firing. A traction biased firing mechanism avoids binding in driving this straightened linked rack in cooperation with an anti-backup mechanism, with a lockout mechanism that prevents releasing the closure trigger during firing. Furthermore, an external indicator gives feedback to the surgeon as to how far firing has progressed, as well as providing a manual retraction capability.
Patent MX-PA04010341-A (MX)
Title: Hose direct canister lid.
Inventor: LUTHER T NIEH
IPC: B65D81/20
Filed: 2003-04-18
Abstract: A hose direct canister lid (10) includes a port (22) that accepts a hose connected to a source of vacuum in order to evacuate a canister to which the lid is connected. The hose direct canister lid includes a first valve (50) for exposing the canister to the source of vacuum when the vacuum hose is secured to the lid, and wherein the first valve closes when the source of vacuum is removed in order to seal the lid and canister from ambient. The hose direct canister includes a second valve (39) used to break the vacuum and expose the interior of the canister to ambient.
Patent MX-PA04012381-A (MX)
Title: 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia.
Inventor: ZHU YUPING
IPC: C07D249/08
Filed: 2003-06-06
Abstract: Compounds having Formula (I), including pharmaceutically acceptable salts, hydrates and solvates thereof, are selective inhibitors of the 11beta-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.
Patent MX-PA05000212-A (MX)
Title: Knife retraction arm for a curved cutter stapler.
Inventor: SCHWEMBERGER RICHARD
IPC: A61B17/072
Filed: 2005-01-03
Abstract: A surgical instrument for cutting and applying a plurality of surgical fasteners in the same direction to body tissue includes a frame having a proximal end and a distal end, with a handle positioned at the proximal end and an end effector positioned at the distal end. The end effector is shaped and dimensioned for supporting a cartridge housing and an anvil. The cartridge housing and anvil are relatively movable between a first spaced apart position and a second position in close approximation with one another, and the cartridge housing includes a knife structure adapted for cutting tissue by moving between the cartridge housing and the anvil. The instrument also includes a firing mechanism associated with the end effector and the cartridge housing for selective actuation of the knife structure and surgical fasteners for movement in the same direction. The knife structure includes a rearwardly facing coupling member shaped and dimensioned for engaging a distal end of the firing mechanism as the cartridge housing is loaded into the end effector of the surgical instrument.