Patent SG-11201900500T-A (SG)
Title: Glucocorticoid-induced tumor necrosis factor receptor (gitr) antibodies and methods of use thereof
Inventor: MARASCO WAYNE A
IPC: C07K16/28
Filed: 2017-07-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) WIP0 I PCT omit °nolo omm 111E1111°111 (10) International Publication Number WO 2018/018039 A3 (51) International Patent Classification: (07x16/28 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2017/043504 (22) International Filing Date: 24 July 2017 (24.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/365,712 22 July 2016 (22.07.2016) US 62/375,634 16 August 2016 (16.08.2016) US (71) Applicant: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue, Boston, Massachu- setts 02215 (US). (72) Inventors: MARASCO, Wayne A.; 43 Rice Street, Wellesley, Massachusetts 02481 (US). ZHU, Quan Karen; 9 Carraige Hill Circle, Southborough, Massachusetts 01772 (US). (74) Agent: ELRIFI, Ivor et al.; Cooley LLP, 1299 Pennsylva- nia Avenue, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 22 February 2018 (22.02.2018) = (54) Title: GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) ANTIBODIES AND METHODS OF USE THEREOF Figure 12 GITR-Ligand vs E1-3H7 IgG4 GITR-Ligand vs TT1-3C6 IgG4 GITR-ligand vs GT1-10 IgGI cc 0 2000 4000 6000 0 2000 4000 6000 0 2000 4000 6 0 00 ngfml ngtml ngiml Anti-GITR-mAb Anti-GITR ImAb &GITRL GITR-Ligand at 333nem1 (57) : The present invention comprises human monoclonal antibodies that bind to GITR (also known as glucocorticoid-induced tumor necrosis factor receptor). Binding of the invented antibody to GITR inhibits binding of its ligand, GITR-L, and can be used to treat cancer. Cr) Cr) O GC 11 O 00 11 O C 4.00E+03 2,00E-F03 0.00E+00 2.00E+04 1.80E+04 1,60E+04 1.40E+04 1.20E-F04 1.00E-F04 8.00E+03 6.00E+03 r 61 \ — — A .... . * .......... prh - A ----------------------------------------------