baber/WOPTO huggingface dataset:
Patent CA-3102060-A1 (CA)
Title: Nav1.7 monoclonal antibody
Inventor: TAKAHASHI TATSUYA
IPC: C12N15/63
Filed: 2019-05-30
Abstract: The purpose of the present invention is to provide a novel Nav1.7 monoclonal antibody. Disclosed is a Nav1.7 monoclonal antibody having six specific CDRs (heavy-chain CDR1 through CDR3 and light-chain CDR1 through CDR3) or a specific heavy-chain variable region/light-chain variable region, or an antibody fragment of the Nav1.7 monoclonal antibody. The monoclonal antibody, etc., can be used in the treatment or prevention of pain, pruritus, etc.
Patent CA-3105146-A1 (CA)
Title: Apparatus and method for the production of microalgae
Inventor: BLANCHARD GERSANDE
IPC: C12M1/00
Filed: 2019-07-05
Abstract: This apparatus (30) for the production of microalgae comprises a vessel (1) intended to receive a culture medium of the microalgae, and a lighting device (6) intended to be positioned in the vessel inside the culture medium. The lighting device (6) is configured to emit light at least in a range of wavelengths useful for the photosynthesis of the microalgae. The apparatus comprises a control system (15) for automatically controlling a power supply of the lighting device (6) so as to adjust the output light intensity of the lighting device (6) according to the concentration of microalgae in the vessel (1).
Patent CA-3105593-A1 (CA)
Inventor: GOSSARD ALBAN
IPC: G21F9/00
Filed: 2019-07-10
Abstract: The invention relates to a method for decontaminating a volume of a gaseous medium contaminated with contaminating species in suspension, said volume of gaseous medium being in contact with at least one surface of a solid substrate, said method comprising the following successive steps: a) the interior of the volume of gaseous medium is sprayed with fine droplets of an inorganic gel, thereby forming a mist, said gel consisting of a colloidal solution, comprising an inorganic viscosity-enhancing agent, and a solvent; b) the contaminating species in suspension are captured by the droplets of the inorganic gel; c) the droplets of the inorganic gel containing the captured contaminating species in suspension are deposited on the surface of the solid substrate; d) the gel is maintained on the surface of the solid substrate at least for a sufficient amount of time for the gel to dry and form a dry solid residue containing the captured contaminating species in suspension; e) the dry solid residue containing the captured contaminating species is recovered.
Patent CA-3107032-A1 (CA)
Inventor: MIRSHEKARI GHOLAMREZA
IPC: A61F2/95
Filed: 2021-01-25
Abstract: A catheter device for use in creating , including, but not limited to, forward-looking images of tissues, cells and organs inside the living body by measuring at least one electrical property thereof. The device comprising at least one elongated and hollow body extending between a proximal end and a distal end along a longitudinal axis, at least one electrically conductive elongated bodies secured to the elongated and hollow body and extending longitudinally along at least a portion of the elongated and hollow body, with the electrically conductive elongated bodies capable of sending or receiving electrical current into or from the targeted tissues, cells and organs.
Patent CA-3107638-A1 (CA)
Title: Composition d'electrolyte contenant un sel metallique alcalin, film electrolytique et methode de fabrication du film electrolytique
Inventor: SHIBATA Shin-ya
IPC: C08F299/00
Filed: 2019-07-05
Abstract: Le but de la présente invention est de fournir une composition d'électrolyte à partir de laquelle un film d'électrolyte peut être obtenu qui a des caractéristiques de cellule supérieures par comparaison avec des films d'électrolyte classiques. La présente invention concerne une composition d'électrolyte comprenant un sel de métal alcalin, la composition étant caractérisée en ce qu'elle comprend en outre un monomère photodurcissable et/ou thermodurcissable et un agent de dissociation de sel, et la teneur du sel de métal alcalin est supérieure ou égale à 50 % en masse par rapport au total de 100 % en masse du sel de métal alcalin, du monomère photodurcissable et/ou thermodurcissable, et de l'agent de dissociation de sel.
Patent CA-3114707-A1 (CA)
Title: Molecules de recruteurs de cellules nk et leurs methodes d'utilisation
Inventor: MILLER JEFFREY S
IPC: C07K16/30
Filed: 2019-10-17
Abstract: L'invention concerne des compositions permettant d'activer des cellules NK pour stimuler une réponse immunitaire pour le traitement du cancer et d'autres troubles. Dans un mode de réalisation, l'invention concerne un composé comprenant un domaine de recrutement de cellules NK qui se lie au CD 16 ; un domaine d'activation de cellules NK lié de manière fonctionnelle au domaine de recrutement de cellules NK ; et un domaine de ciblage qui se lie sélectivement à une cellule cible et qui est lié de manière fonctionnelle au domaine d'activation de cellules NK et au domaine de recrutement de cellules NK, le domaine de ciblage se liant au CLEC12A.
Patent CA-3115146-A1 (CA)
Title: A bar hanger assembly with mating telescoping bars
Inventor: KOPITZKE FREDERICK WILLIAM
IPC: F21V21/22
Filed: 2019-10-02
Abstract: A bar hanger assembly is used to couple a housing to a support structure. The bar hanger assembly may include a bar hanger holder to mechanically couple the bar hanger assembly to the housing, such as a junction box, a can housing, or a frame. The bar hanger holder may define a channel to mechanically guide and support a pair of bar hangers. The bar hangers may be mechanically coupled together in a telescoping manner such that the first bar hanger is slidably adjustable with respect to the second bar hanger. The bar hanger holder and each bar hanger may physically contact one another and, in some instances, generate a compressive force to substantially reduce unwanted play. Each bar hanger may include a bar hanger head to couple the bar hanger assembly to various types of support structures, such as a T-bar, a stud, a joist, or a frame.
Patent CA-3120082-A1 (CA)
Title: Fusosome compositions for cns delivery
Inventor: VON MALTZAHN GEOFFREY A
IPC: A61K9/127
Filed: 2019-11-14
Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell- specific regulatory element, and a non-target cell- specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.
Patent CA-3123473-A1 (CA)
Title: Compound for use in retinal diseases
Inventor: LI PENG
IPC: A61P27/00
Filed: 2019-12-18
Abstract: Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt.
Patent CA-3124980-A1 (CA)
Title: Highly accurate de novo polynucleotide synthesis
Inventor: PECK BILL JAMES
IPC: C07H21/02
Filed: 2019-12-23
Abstract: Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
Patent CA-3127613-A1 (CA)
Title: Non-immunosuppressive fk506 analogs and use thereof
Inventor: LIU JUN O
IPC: A61P29/00
Filed: 2020-01-23
Abstract: The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds.
Patent CA-3129530-A1 (CA)
Title: Neural feedback loop filters for enhanced dynamic range magnetoencephalography (meg) systems and methods
Inventor: LEDBETTER MICAH
IPC: G01R33/025
Filed: 2020-01-24
Abstract: One embodiment is a magnetic field measurement system that includes at least one magnetometer having a vapor cell, a light source to direct light through the vapor cell, and a detector to receive light directed through the vapor cell; at least one magnetic field generator disposed adjacent the vapor cell; and a feedback circuit coupled to the at least one magnetic field generator and the detector of the at least one magnetometer. The feedback circuit includes at least one feedback loop that includes a first low pass filter with a first cutoff frequency. The feedback circuit is configured to compensate for magnetic field variations having a frequency lower than the first cutoff frequency. The first low pass filter rejects magnetic field variations having a frequency higher than the first cutoff frequency and provides the rejected magnetic field variations for measurement as an output of the feedback circuit.
Patent CA-3131275-A1 (CA)
Title: Procede et systeme de generation d'un hybride polymere-perovskite
Inventor: MAHESHWARI VIVEK
IPC: C08J3/20
Filed: 2020-02-25
Abstract: La présente invention concerne un procédé et un appareil de génération d'un hybride polymère-perovskite (PPH). Le PPH peut ensuite être utilisé dans la fabrication d'un produit final, tel qu'une cellule solaire ou des détecteurs de photons. Le PPH est généré par le mélange d'une solution de précurseur comprenant un composant chimique d'acide de Lewis et un composant cationique avec un polymère. Le mélange est ensuite synthétisé pour générer le PPH.
Patent CA-3131712-A1 (CA)
Inventor: UNDERWOOD DENNIS J
IPC: A61K9/72
Filed: 2020-02-21
Abstract: Un agent thérapeutique pour traiter des voies respiratoires d'un sujet comprend un ou plusieurs types ou tailles de particules, chaque particule comprenant à son tour une enceinte biodégradable contenant un mucolytique ou un autre médicament en son sein. Un appareil de dispersion peut être utilisé pour administrer des doses mesurées de mucolytique et peut être conçu pour une auto-administration par le sujet. L'encapsulation du mucolytique dans une formulation liposomale peut empêcher une oxydation prématurée et maintenir l'efficacité du médicament lors de l'administration à un emplacement cible dans les voies respiratoires supérieures ou inférieures.
Patent CA-3133465-A1 (CA)
Inventor: SHARON YOAV
IPC: G01R25/00
Filed: 2020-03-23
Abstract: A method of determining the topology of a portion of the electrical distribution grid such as a feeder based on voltage and current measurements. The method employs Bayesian-based topology detection, where voltage and current data is measured at switches in the feeder at numerous sample times. A voltage variance is calculated for each switch, along with a voltage correlation coefficient for each pair of switches. Voltage variance is used to establish a preliminary position of a switch in the feeder, where switches closest to the substation source are expected to exhibit the least variance, and vice versa. The voltage correlation coefficient is used to provide a first determination of whether two switches are in series with each other in a parent-child relationship, and a current magnitude comparison is used to confirm or refute the preliminary parent-child relationship between the two nodes.
Patent CA-3134355-A1 (CA)
Inventor: TSAI CHING-FU
IPC: A61N1/36
Filed: 2021-10-15
Abstract: A method for operating a health-care device is disclosed. The proposed method includes steps of coaxially aligning a central opening of a bottom connector and a specific part or an acupoint of a user's body, causing a device positioning piece positioned on the user's body, causing a work body mounted on the bottom connector, and operating a work piece to form a working relation between a working end thereof and the acupoint or the specific part, and a positional relation therebetween.
Patent CA-3140694-A1 (CA)
Inventor: WALTZ KEVIN L
IPC: A61F2/14
Filed: 2020-05-04
Abstract: A device for reducing incidence of surgical debris migration within a mammalian eye comprising an anterior portion with an anterior inner surface and an anterior outer surface, the anterior inner surface and the anterior outer surface terminating at an anterior edge that defines an open anterior end; and a posterior portion, with a posterior inner surface and a posterior outer surface, the posterior inner surface and the posterior outer surface terminating at a posterior edge, the posterior edge defining an open posterior end; and a waist connecting the anterior portion and the posterior portion, the waist comprising a waist inner surface and a waist outer surface; and an aperture extending from the open anterior end, through the waist, to the open posterior end, the aperture bounded by the anterior inner surface, the waist inner surface, and the posterior inner surface.
Patent CA-3143309-A1 (CA)
Inventor: DEFOER JOHAN
IPC: C08J5/18
Filed: 2020-06-15
Abstract: La présente invention concerne une composition de copolymère de propylène comprenant (A) de 50,0 à 90,0 % en poids, sur la base de la quantité totale de la composition de copolymère de propylène, d'un copolymère de propylène hétérophasique ayant une phase de matrice et une phase élastomère dispersée dans ladite phase de matrice, la phase de matrice étant un copolymère aléatoire de propylène, le copolymère de propylène hétérophasique ayant en outre un indice de fluidité MFR2 de 0,2 à 12,0 g/10 min, déterminé selon la norme ISO 1133 à une température de 230 °C et une charge de 2,16 kg, et une fraction soluble à froid dans le xylène (XCS) dans la plage de 20,0 à 50,0 % en poids sur la base de la quantité totale du copolymère de propylène hétérophasique (A), déterminée selon la norme ISO 16152 à une température de 25 °C, (B) de 5,0 à 25,0 % en poids, sur la base de la quantité totale de la composition de copolymère de propylène, d'un plastomère à base de propylène ayant une densité dans la plage de 845 à 870 kg/m³, déterminé selon la norme ASTM D1505 sur des éprouvettes moulées par compression et un indice de fluidité MFR2 de 1,0 à 30,0 g/10 min, déterminé selon la norme ISO 1133 à une température de 190 °C et une charge de 2,16 kg, et (C) de 5,0 à 25,0 % en poids, sur la base de la quantité totale de la composition de copolymère de propylène, d'un plastomère à base d'éthylène ayant une densité dans la plage de 850 à 900 kg/m ³, déterminé selon la norme ISO1183D sur des éprouvettes moulées par compression et un indice de fluidité MFR2 de 0,5 à 30,0 g/10 min, déterminé selon la norme ISO 1133 à une température de 190 °C et une charge de 2,16 kg, un article comprenant ladite composition de copolymère de propylène et l'utilisation de ladite composition de copolymère de propylène dans un revêtement d'étanchéité monocouche.
Patent CA-3143801-A1 (CA)
Title: Expanded low-density polyethylene insulation composition
Inventor: MIAO WENKE
IPC: C08K7/22
Filed: 2019-07-01
Abstract: A cable includes (a) a conductor; and (b) an expanded polymeric coating surrounding at least a portion of the conductor, the expanded polymeric coating including: (i) 70.0 wt. % to 99.8 wt. % low-density polyethylene homopolymer; and (ii) 0.2 wt. % to 5.0 wt.% of expanded polymeric microspheres having a D50 average diameter of from 25 µm to 40 µm, wherein the expanded polymeric coating has a density of 0.75 g/cc or less.
Patent CA-3144961-A1 (CA)
Inventor: HE XIAO
IPC: A61K39/395
Filed: 2020-06-30
Abstract: La présente invention concerne des anticorps hétérodimères qui se lient à deux antigènes cibles différents en même temps. Dans un mode de réalisation, les anticorps hétérodimères sont des anticorps bispécifiques. Dans un mode de réalisation, les anticorps hétérodimères comprennent trois polypeptides comprenant : un premier polypeptide comprenant un polypeptide de fusion scFv-Fc; un deuxième polypeptide comprenant une chaîne lourde d'immunoglobuline; et un troisième polypeptide comprenant une chaîne légère d'immunoglobuline. Dans un mode de réalisation, le premier polypeptide comprend une ou plusieurs mutations ponctuelles qui confèrent une stabilité thermique accrue au premier polypeptide.
Patent CA-3148796-A1 (CA)
Title: Compositions azeotropes et de type azeotrope comprenant du neopentane et des isomeres de hfo-1336 mzz
Inventor: MUSYIMI HARRISON K
IPC: C09K3/30
Filed: 2020-10-08
Abstract: La présente invention concerne des compositions azéotropes et de type azéotrope comprenant du néopentane et un composé choisi parmi le E-1,1,1,4,4,4-hexafluoro-2-butène (HFO-1336 mzz(E)) et Z-1,1,1,4,4,4-hexafluoro-2-butène (HFO-1336 mzz(Z)). L'invention concerne également des procédés d'utilisation des compositions de l'invention dans des applications de propulseurs, des applications de transfert de chaleur et des applications de réfrigération.
Patent CA-3150736-A1 (CA)
Title: Process of making cftr modulators
Inventor: ANGELL PAUL
IPC: C07D231/20
Filed: 2020-08-13
Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
Patent CA-3150812-A1 (CA)
Inventor: TAO JING
IPC: A61K31/47
Filed: 2020-09-10
Abstract: The present application is directed to a pharmaceutical composition comprising (<i>R</i>)-<i>N</i>-(4-chlorophenyl)-2-((1<i>S</i>, 4<i>S</i>)-4-(6-fluoroquinolin-4-yl) cyclohexyl) propanamide methane sulfonic acid salt that is resistant to salt disproportionation: (I)
Patent CA-3153180-A1 (CA)
Inventor: SHIHOR ROI
IPC: A47K10/42
Filed: 2020-09-24
Abstract: A hangable and expandable prism-shaped dispensing package comprising a base wall; a top wall having a rear edge and a front edge; at least one side expansion wall extending between said base wall and said top wall, expandable between a compacted state and an expanded state; a hanging arrangement for hanging of the dispensing package having a hanging portion which at a hanging position is disposed closer to the rear edge than the front edge; and a dispensing location configured to facilitate dispensing of sheet material therethrough. The dispensing location being disposed at a top portion of the dispensing package.
Patent CA-3154110-A1 (CA)
Title: Methodes de detection d'une reponse immunitaire specifique d'un aliment
Inventor: PETERSON KATHRYN A
IPC: A61K51/04
Filed: 2020-10-08
Abstract: Sont divulgués, des méthodes de diagnostic et de traitement d'un sujet présentant une ?sophagite à éosinophiles (EoE) active ou inactive. Les méthodes peuvent comprendre les étapes consistant à détecter si un niveau d'un ou plusieurs anticorps d'immunoglobuline est élevé dans un échantillon de sécrétion ?sophagienne obtenu à partir d'un sujet, à diagnostiquer que le sujet présent une EoE active lorsque le niveau d'un ou de plusieurs anticorps immunoglobulines dans l'échantillon est élevé au-dessus d'une valeur seuil prédéterminée et à diagnostiquer que le sujet présente une EoE inactive lorsque le niveau d'un ou de plusieurs anticorps immunoglobulines dans l'échantillon est inférieur à une valeur seuil prédéterminée ; et à traiter le sujet chez lequel a été diagnostiquée une EoE active.
Patent CA-3155168-A1 (CA)
Inventor: MAHER JOHN
IPC: A61K39/00
Filed: 2020-09-23
Abstract: La présente invention concerne des polypeptides de fusion comprenant un polypeptide de protéine d'activation de DNAX 10 (DAP10) et un polypeptide de protéine d'activation de DNAX 12 (DAP12). L'invention concerne également des cellules comprenant de telles protéines de fusion et leur utilisation dans le traitement du cancer.
Patent CA-3155551-A1 (CA)
Title: Automated license plate recognition system and related method
Inventor: BLAIS-MORIN LOUIS-ANTOINE
IPC: G01S19/43
Filed: 2020-08-06
Abstract: Systems, methods, devices and computer readable media for determining a geographical location of a license plate are described herein. A first image of a license plate is acquired by a first image acquisition device of a camera unit and a second image of the license plate is acquired by a second image acquisition device of the camera unit. A three-dimensional position of the license plate relative to the camera unit is determined based on stereoscopic image processing of the first image and the second image. A geographical location of the camera unit is obtained. A geographical location of the license plate is determined from the three-dimensional position of the license plate relative to the camera unit and the geographical location of the camera unit. Other systems, methods, devices and computer readable media for detecting a license plate and identifying a license plate are described herein.
Patent CA-3156700-A1 (CA)
Inventor: SHIMIZU SHINOBU
IPC: A61K35/28
Filed: 2020-10-30
Abstract: The purpose of the present invention is to provide a novel medical application using pluripotent stem cells in regenerative medicine. The present invention provides a cell formulation and pharmaceutical composition that are for amelioration and therapy for frequent urination and bladder pain caused by the inflammation of the bladder and that contain SSEA-3 positive pluripotent stem cells isolated from cultured mesenchymal cells or a mesenchymal tissue of a living organism. The cell formulation according to the present invention is considered to be based on a mechanism in which, for example, Muse cells are administered against interstitial cystitis having the abovementioned disorders to be successfully engrafted into affected bladder tissue, whereby the disorders are ameliorated and treated.
Patent CA-3156942-A1 (CA)
Inventor: KURTIS ASHLEY
IPC: H04N7/14
Filed: 2020-10-22
Abstract: A method of providing secure communication between first (110) and second (120) devices comprises the first device and the second device connecting to a server (102) via a secure communication channel (130). Encryption keys for the devices are generated and data relating to the encryption keys are exchanged via the server in the secure communication channel. A peer-to-peer connection for exchanging data is generated using encrypted connection information for the devices.
Patent CA-3157420-A1 (CA)
Title: Direct drive fan system with variable process control
Inventor: COSTELLO JOSEPH
IPC: F04D27/00
Filed: 2012-10-21
Abstract: There is provided a method for operating a fan in a cooling tower wherein the fan cools liquids used in an industrial process. A direct-drive variable speed motor, permanent magnet motor rotates the fan at a rotational speed. A variable process control system comprising a programmable motor controller provides power signals to the variable speed, permanent magnet motor, the programmable motor controller having a data storage resource for storing a predetermined motor deceleration operation curve that decelerates the motor in accordance with a predetermined negative ramp rate. Power signals are provided to the direct-drive variable speed motor, permanent magnet motor that correspond to the predetermined motor deceleration operation curve to decrease the motor speed to 0.0, RPM.
Patent CA-3160153-A1 (CA)
Title: Prmt5 inhibitors
Inventor: MACHACEK MICHELLE
IPC: A61K31/4725
Filed: 2020-12-14
Abstract: The present invention provides a compound selected from: compounds A, B, C, D and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutical compositions comprising compounds disclosed herein, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.