Patent SG-11201407878V-A (SG)
Title: Therapeutic agent or prophylactic agent for dementia
Inventor: MORI HIROSHI
IPC: C12N15/02
Filed: 2013-05-30
Abstract: (i2) mwu ft iz s-5 iv x m £ titz s issaj n d9) mm IHMMi (43) m&'&m a 2013^12^ 5 0(05.12.2013) WIPOIPCT (10) WO 2013/180238 A1 (51) A61K39/395 (2006.01) A61P 25/28 (2006.01) C07K16/18 (2006.01) (21) (22) (25) (26) s In: C12N15/02 (2006.01) C12P 21/08 (2006.01) C07K16/46 (2006.01) PCT/JP2013/065090 2013 ^ 5 M 30 0(30.05.2013) 0*lg (30) fiBfefix — £: 2012-124336 2012 ^ 5 .E 31 0(31.05.2012) JP (71) miA: lA^&AABRrfTilA^ (OSAKA CITY UNIVERSITY) [JP/JP]; T 5588585 AEfcJfrAE* TfTlici g 3 § 1 3 8-^ Osaka (JP).'S' A 7 y — ^^5C^tt(TEIJIN PHARMA LIMITED) [JP/JP]; T 1000013 2§ 1 Tokyo (JP). (72) ^ ^(MORI, Hiroshi); T5458585 AlKJtt ABfcTtm^rE JIH7-T g 4 # 3 '&SD&- /i A A BR rfT tL A ^ l*l_ Osaka (JP). g Hi ft H (TOMIYAMA, Takami); T 5458585 AlKJtt AlKrfT j®! fSiFEJiSBr-Tg 4#3-^ ^aA^AABR rfT tL A ^ fa Osaka (JP). \'k % — (MAT- SUMOTO, Yoichi); T 1910065 0 SrrfT E3T g 3 # 2 5Jf^-t2 >J* — fa Tokyo (JP). ?IP JA (EGUCHI, Hiroshi); T 1910065 ^5iiR0S?rtrJii^HraTg 3 mm ?ifA7 7--7tt3c^a £ —fa Tokyo (JP). AS — (KUNORI, Yuichi); T 1910065 ^5liR0S?rtTjli^HraTg 3 # 2 ^ Tokyo (JP). (74) '('t IM A : W ^ H , ^1- (AOKI, Atsushi et al.); T 1058423 KifvtlUSEtft/P^HT g 5 # 1 J % /P^37i FJT Tokyo (JP). (8i) Jt^ia (^ro&i^psy > IS ^ pj f I): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) *!£H (asrofci^isy > ±T(Dmm(Dfcm% V&tf nlfb): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), n. — V [&£%] (54) Title: THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMENTIA = (54) I 00 m CJ o 00 i-H en i-H o CJ o & m (1-UTrialStJB AA iV.T j 40 W) 30 CC 20 10 3 4 (0 §)DD EE non Tg vs Tg : p=0.0071 FF Tg vs Iirmunized Tg : p=0.0029 GG AA (1-1) Trial Experiment BB Time until arrival at hidden platform CC Seconds DD Day EE Significant difference FF Non-Tg vs. Tg: p 0.0071 = GG Tg vs. Immunized Tg: p = 0.0029 -Tg+pSer413 -Tg+PBS ••nonTg+PBS (57) Abstract: The present invention provides a novel therapeutic agent or prophylactic agent for dementia. The present invention provides a therapeutic agent, prophylactic agent, or the like for dementia that contains substance a such as the following as an active ingredient: antibodies that specifically ex­ hibit an antigen-antibody reaction to tau proteins of which the area around Serf 13 of SEQ ID NO: 1 is phosphorylated; and peptides of which the area around Serf 13 phosphorylated. is (57)®$: \"t\"-5> >- <t <fc-5> 0 fflE^y#\"^- 1©Se r 4 1 3J! fofclfoZ?&&&•$>> S e r 4 1 3Jia^'J £JS&-f<g>0 WO 2013/180238 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll llll llll lllll lllll lllllll llll llll T (AM, AZ, BY, KG, KZ, RU, TJ, TM), 3 — • V / ^ (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, _ GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI — (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (&&£ 21 &(3)) (StfJJ 5.2(a))