Patent SG-11201811015R-A (SG)
Title: Antibodies specific for hyperphosphorylated tau and methods of use thereof
Inventor: PEDERSEN JAN
IPC: C07K16/18
Filed: 2017-07-07
Abstract: X 10000 7500 3 5000 2500 I- (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 January 2018 (18.01.2018) W I PO I PCT omit °nolo omm olonmll °nom oimIE (10) International Publication Number WO 2018/011073 Al (51) International Patent Classification: C07K 16/18 (2006.01) A61P 25/28 A61K 39/395 (2006.01) A61K 49/00 G01N 33/68 (2006.01) A61K 39/00 (21) International Application Number: PCT/EP2017/067067 (22) International Filing Date: 07 July 2017 (07.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PA201600416 12 July 2016 (12.07.2016) DK PA201700005 04 January 2017 (04.01.2017) DK PA201700008 04 January 2017 (04.01.2017) DK PA201700179 14 March 2017 (14.03.2017) DK (71) Applicant: H. LUNDBECK A/S [DK/DK]; Ottiliavej 9, 2500 Valby (DK). (72) Inventors: PEDERSEN, Jan, Torleif; c/o H. Lundbeck A/ S Ottiliavej 9, 2500 Valby (DK). KVERGAARD, Krist- ian; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). PEDERSEN, Lars, Ostergaard; c/o H. Lundbeck A/S Ot- tiliavej 9, 2500 Valby (DK). ASUNI, Abdur-Rasheed; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). ROSEN- QVIST, Nina, Helen; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). DAECHSEL, Justus, Claus, Alfred; c/ o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). JUHL, Karsten; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Val- by (DK). TAGMOSE, Lena; c/o H. Lundbeck A/S Ot- tiliavej 9, 2500 Valby (DK). MARIGO, Mauro; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Valby (DK). JENSEN, Thomas; c/o H. Lundbeck A/S Ottiliavej 9, 2500 Val- by (DK). CHRISTENSEN, Soren; c/o H. Lundbeck A/ S, Ottiliavej 9, Valby, 2500 (DK). DAVID, Laurent; c/ o H. Lundbeck A/S, Ottiliavej 9, by, 2500 (DK). VOL- BRACHT, Christiane; c/o H. Lundbeck A/S, Valby, 2500 (DK). HELBO, Lone; c/o H. Lundbeck A/S, Ottiliavej 9, Valby, 2500 (DK). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (2006.01) (2006.01) (2006.01) (54) Title: ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF Figure 1 nM antibody n C10-2 • C10-2_1432S_ q C10-2_N32S_A101T (57) : The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer s disease and other tauopathies. [Continued on next page] WO 2018/011073 Al MIDEDIMOHNIIMEIHRIglillEillIHMEHOM TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))