baber/WOPTO huggingface dataset:
Patent AU-2016305331-A1 (AU)
Title: Capped and uncapped antibody cysteines, and their use in antibody-drug conjugation
Inventor: ZHONG XIAOTIAN
IPC: C07K16/00
Filed: 2016-08-09
Abstract: An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.
Patent AU-2016307976-A1 (AU)
Title: An improved refolding process for antibody's fragments
Inventor: SOMANI SANDEEP
IPC: C07K16/06
Filed: 2016-08-17
Abstract: The invention provides refolding process of Ranibizumab wherein the solubilized solution of heavy chain and/or light chain of Ranibizumab treated with refolding buffer under suitable conditions including pH, temperature and incubation period and the pH and temperature shift is performed at suitable interval to obtain high quality and quantity of refolded protein.
Patent AU-2016308383-A1 (AU)
Title: Purification of FKPA and uses thereof for producing recombinant polypeptides
Inventor: FONG CHRIS B
IPC: C07K16/12
Filed: 2016-08-19
Abstract: The present invention provides methods for producing FKBP-type peptidyl-prolyl cis-trans isomerase (FkpA) polypeptides at very high levels of purity. Also provided are ultrapure FkpA and methods of using same, e.g., for use in immunoassays to show removal of FkpA from biologies produced in bacteria. In addition, the present invention provides methods of purifying polypeptides (e.g., multispecific antibodies) produced in bacteria overexpressing one or more chaperones. The methods include affinity chromatography, mixed-mode chromatography and hydrophobic interaction chromatography. In some aspects, the invention provides compositions of polypeptides (e.g., multispecific antibodies) that are essentially free of product-specific impurities.
Patent AU-2016314390-A1 (AU)
Title: Small molecule compound for enhancing plant stress resistance
Inventor: ZHU JIANKANG
IPC: C07D215/38
Filed: 2016-04-29
Abstract: Disclosed are a small molecule compound for enhancing plant stress resistance, a preparation method therefor, and application thereof. Specifically, disclosed are compounds as shown in formula I, salts thereof, optical isomers thereof, racemes thereof, solvates thereof, or precursors thereof. Moreover, the compound of the present invention is a substitute of ABA, can significantly improve the plant stress resistance, and thus has an extremely wide application prospect.
Patent AU-2016329815-A1 (AU)
Title: Smart garment, user terminal, system including same, and method of changing design of smart garment
Inventor: KIM KYONG IL
IPC: G06F17/30
Filed: 2016-04-01
Abstract: The disclosed embodiments provide a smart garment on which implemented designs can be changed in terms of color, image, text, etc. Also, a system is provided that comprises: a server for providing various designs to be implemented on a smart garment; and a user terminal that can change the design of the smart garment by receiving various designs from the server and transmitting same to the smart garment. The system according to the disclosed embodiments comprises: a server including a design database for a smart garment; a user terminal for downloading a design for the smart garment from the server; and the smart garment on which the design transmitted from the user terminal is implemented.
Patent AU-2016336050-A1 (AU)
Title: Stabilizing system for a knee brace
Inventor: GARRISH ROBERT
IPC: A61F5/01
Filed: 2016-09-27
Abstract: A knee brace for assisting the extension or flexing of a limb comprises substantially rigid upper and lower frames connected by a hinge, the upper frame being secured to the leg by an upper strap. A stabilizing strap for fixing the lower frame to the user's leg comprises an inelastic band, cord or other flexible securing member for circumscribing the user's leg having a fastening element for fixing the securing member in a set position. The securing member is affixed to the arms of the lower frame, slidably extending through at least one strap support provided by at least one of the arms of the lower frame. When the brace is in position on a user's leg the stabilizing strap is able to move through at least one strap support in a generally horizontal direction while supporting the lower frame in the vertical direction.
Patent AU-2016344885-A1 (AU)
Title: Power conversion system and control device
Inventor: TERAMOTO YUICHIRO
IPC: H02J9/06
Filed: 2016-08-10
Abstract: A power conversion system (10), wherein a first control unit (12a) acquires monitoring data from a first power storage unit (20a), alerts a second control unit (12b) of the remaining capacity of the first power storage unit (20a), and sets the output voltage of a first DC-AC conversion unit (11a). The second control unit (12b) controls, on the basis of the total current supplied to a load (2), the remaining capacity of the first power storage unit (20a) and the remaining capacity of a second power storage unit (20b), the output current of a second DC-AC conversion unit (11b) so that there is less difference between the remaining capacity of the first power storage unit (20a) and the remaining capacity of the second power storage unit (20b).
Patent AU-2016352829-A1 (AU)
Title: Resistance to ToLCNDV in squash
Inventor: MAZET JULIEN
IPC: A01H1/04
Filed: 2016-11-10
Abstract: The invention provides a Tomato Leaf Curl New Dehli Virus (ToLCNDV) tolerance or resistant QTL in cucurbit plants and plants comprising the QTL. The invention also provides molecular markers linked to QTL. The invention further provides methods of breeding to produce plants that are resistant to ToLCNDV, and the resistant plants produced by such methods.
Patent AU-2016370779-A1 (AU)
Title: Quinoline-3-carboxamides as H-PGDS inhibitors
Inventor: CADILLA RODOLFO
IPC: A61P21/00
Filed: 2016-12-15
Abstract: The present invention relates to compounds of Formula (XI) wherein R
Patent AU-2016391628-A1 (AU)
Title: Techniques for configuring reference signals in low latency wireless communications
Inventor: PATEL SHIMMAN ARVIND
IPC: H04L5/00
Filed: 2016-12-12
Abstract: Various aspects described herein relate to determining a configuration of reference signal (RS) resources in wireless communications. A scheduling grant of resources can be received from an access point, wherein the scheduling grant indicates one or more parameters related to transmission locations of one or more RSs. RS resource locations can be determined for the one or more RSs based at least in part on the one or more parameters. The one or more RSs can be received over the RS resource locations allowing for decimation of the RSs in time and/or frequency.
Patent WO-2018058196-A1 (WO)
Title: Sectionneur à coupure visible d'interrupteur fermé
Inventor: O'SULLIVAN NEIL EDWARD
IPC: H01H33/662
Filed: 2017-09-28
Abstract: La présente invention concerne un ensemble appareillage de commutation électrique (100) comprenant : une paire de contacts électriques (104a, 104b) ; une douille (200) définissant une chambre interne (201) dans laquelle sont situés les contacts électriques ; un dispositif de visualisation (208), comprenant de manière appropriée un carreau de vitre (620), dans la douille pour permettre la visualisation d'un état ouvert ou fermé des contacts dans la chambre interne ; et un ou plusieurs écrans de commande de champ électrique (600, 602), incorporés de manière appropriée dans un corps diélectrique (206) de la douille, pour commander un champ électrique généré par la paire de contacts (104) pour créer un champ électrique (E) sensiblement uniforme entre les contacts afin de réduire la contrainte électrique à l'intérieur de la chambre interne (201).
Patent AU-2017202306-A1 (AU)
Title: System and method for analyzing operation of component of machine
Inventor: JACOBSON EVAN E
IPC: G06Q50/30
Filed: 2017-04-07
Abstract: Abstract SYSTEM AND METHOD FOR ANALYZING OPERATION OF COMPONENT OF A system for analyzing one or more operations associated with a component of a machine is disclosed. The system includes a data warehouse for storing data associated with the machine. The system includes a data extraction module, which extracts the data from the data warehouse and receives a customer input. The data extraction module generates an input parameter based on the data from the data warehouse and the customer input. The system includes a failure injection module for storing information of the one or more failures associated with the component of the machine. The system also includes a machine model, which is in communication with the data extraction module and the failure injection module. The machine model derives an output parameter associated with the one or more operations of the component of the machine, based on the input parameter and the information of the one or more failures. 0 Cz Sow 00 u -q OH H8 EgN Ei U sa li BO su C) 0 F. o zz z- U 0 u~ D 8u
Patent AU-2017203474-A1 (AU)
Title: Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
Inventor: LIU NINGSHU
IPC: A61K31/517
Filed: 2017-05-24
Abstract: The present invention relates to: - use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active 5 agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more further active agents, for the preparation of a medicament for the treatment or prophylaxis of cancer; combinations of a) said compound and b) one or more further active agents; - a pharmaceutical composition comprising said compound as a sole active agent for o the treatment of breast cancer; - a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; - use of biomarkers involved in the modification of Bcl expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN for predicting the sensitivity and/or resistance of a cancer patient to said compound and providing a rationale 5 based synergistic combination as defined herein to increase sensitivity and/or to overcome resistance; and - a method of determining the level of a component of one or more of Bcl expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN. 9091340_1 (GHMatters) P94796AU.1
Patent AU-2017203735-A1 (AU)
Title: Device for evaporating a volatile material
Inventor: DUFFIELD PAUL
IPC: A61L9/03
Filed: 2017-06-02
Abstract: Abstract An assembly for evaporating a volatile material is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough; and wherein the refill comprises at least one susceptor and a substantially liquid-tight sealed reservoir containing the volatile material; wherein, in use, the susceptor(s) is arranged to heat the material when the susceptor(s) is at least partially positioned in the induced magnetic field generated, in use, when said alternating current is passed through the induction coil. Refills, devices and methods of use are also described. Magnetic 201 205 Field 204 H1 I-.-203 101 103 102 Fig. I
Patent AU-2017204268-A1 (AU)
Title: Fuel cell module
Inventor: MATSUNO TAKESHI
IPC: C01B3/02
Filed: 2017-06-23
Abstract: A fuel cell module according to the present embodiment includes a hydrodesulfurizer, a cell stack, an exhaust gas channel portion, and an air-preheating channel portion. The 5 hydrodesulfurizer is configured to desulfurize fuel gas using a hydrodesulfurization catalyst. A reformer is configured to generate a hydrogen-containing gas. The cell stack is constituted by stacking a plurality of fuel cells and is configured to generate electric power. The exhaust gas channel portion is 10 configured to discharge the hydrogen-containing gas, and discharge exhaust gas that is generated by the combustion of the oxygen-containing gas. The air-preheating channel portion is an air-preheating channel portion that is disposed so as to be adjacent to the exhaust gas channel portion and that is configured 15 to preheat the oxygen-containing gas through heat exchange with the exhaust gas channel portion. The air-preheating channel portion is disposed between the hydrodesulfurizer and the cell stack. MI Il ITD( C) ,N C 'T C AA =ICDi IIl 0 I OO(D~~~~ ID C oz C 0
Patent AU-2017210546-A1 (AU)
Title: Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism
Inventor: HOLBEIN BRUCE EDWARD
IPC: A61K9/00
Filed: 2017-08-02
Abstract: METAL CHELATING COMPOSITIONS AND METHODS FOR CONTROLLING THE GROWTH OR ACTIVITIES OF A LIVING CELL OR ORGANISM Abstract The present invention provides for metal chelating compositions which are soluble in aqueous media. The present invention also provides chelating compositions that possess acceptable iron sequestering strengths and are able to present a physical form that potentially inhibits (e.g. does not permit easy) access of iron sequestered by the compositions to the cells being targeted. Compositions comprising chelating aspects affixed to or incorporated into suitable carrier materials such that the resulting metal chelating composition is soluble in aqueous media are also provided. Disclosed herein are chelating compositions, for chelating one or more essential metals. The chelating compositions being soluble in an aqueous medium and comprising one or more metal binding chemical groups affixed to or incorporated into the structure of a carrier material, such that the resulting chelating composition is able to bind one or more metals, and remains substantially soluble in the aqueous medium with its bound metal or metals.
Patent AU-2017213633-A1 (AU)
Title: Enhanced production of immunoglobulins
Inventor: KILLEEN NIGEL
IPC: C40B40/08
Filed: 2017-02-03
Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
Patent AU-2017225876-A1 (AU)
Title: Methods and systems for evaluating tumor mutational burden
Inventor: CHALMERS ZACHARY R
IPC: C40B70/00
Filed: 2017-02-27
Abstract: Methods of evaluating tumor mutational burden in a sample, e.g., a tumor sample or a sample derived from a tumor, from a subject, are disclosed.
Patent AU-2017228277-A1 (AU)
Title: Rotary heat exchanger
Inventor: MILLER MATTHEW C
IPC: F28D11/02
Filed: 2017-02-24
Abstract: Rotary heat exchangers can include a ride-along compressor, at least a portion of which can be rotated along with the heat exchanger. By rotating at least a portion of the compressor along with the heat exchanger, a sealed fluid circuit containing a two-phase working fluid can be provided. A rotary heat pump or heat engine can include an evaporator and a condenser in the form of back-to-back centrifugal fans. The centrifugal fan blades or other portions of the evaporator and condenser may include internal cavities where the working fluid undergoes a phase change.
Patent AU-2017234150-A1 (AU)
Title: Compositions and methods for phosphoramidite and oligonucleotide synthesis
Inventor: BUTLER DAVID CHARLES DONNELL
IPC: C07H21/00
Filed: 2017-03-13
Abstract: The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
Patent AU-2017240210-A1 (AU)
Title: Crane trolley
Inventor: LINDBERG TEPPO
IPC: B66C11/00
Filed: 2017-03-29
Abstract: The invention relates to a trolley of a crane, arranged to move along a main support structure (2) of the crane, whereby the trolley (1) comprises a support frame structure (3); bearing wheels (4) which are fastened to the support frame structure and by means of which the trolley is ar- ranged to move along the main support structure; a hoisting mechanism that has a rope drum (5) for a hoisting rope, a rope pulley arrangement (7) through which the hoisting rope may be guided from the rope drum to a fixed fastening point on the trolley, and a hoisting member in cooperation with the hoisting rope for hoisting a load; whereby the rope drum (5) is supported to the support frame structure of the trolley so that the axle (5a) of the rope drum is parallel to the main support structure; whereby the rope pulley ar- rangement (7)is located, in the axial direction of the rope drum (5), at least partly outside one rope drum end which is on the side of said fastening point; and whereby the support frame structure (3) is divided into two separate frame parts, whereby the first frame part (3a) supports the rope pulley arrangement and the rope drum end on the side thereof, and whereby the second frame part (3b) supports the opposite end of the rope drum.
Patent AU-2017264693-A1 (AU)
Title: Secure multi-factor tokenization-based push/response commerce platform
Inventor: SARKISSIAN SHAUNT M
IPC: G06Q20/32
Filed: 2017-05-09
Abstract: Example methods, apparatuses, and systems are presented that allows a user to make a secure purchase online, directly through accessing an online advertisement and without being redirected to multiple, cumbersome webpages to process different pieces of information to complete the transaction, while still leveraging existing e-commerce entities, such as existing payment platforms and existing ad/content networks. The present system includes a commerce ads engine (CA engine) that interfaces with the user through an app associated with the CA engine, a tokenization platform for authentication of the user, and a merchant providing relevant offer and check out information about a product being advertised in an online ad. The present system integrates new information embedded into online advertisements that interfaces with the CA engine and allows for the user to reliably provide authentication while purchasing the desired product, and without accessing or being redirected to multiple websites as is conventionally done.
Patent AU-2017268670-A1 (AU)
Title: Method of Host-Directed Illumination and System for Conducting Host-Directed Illumination
Inventor: PEIRCE MICHAEL
IPC: G06V10/141
Filed: 2017-12-01
Abstract: A method of host-directed illumination for verifying the validity of biometric data of a user is provided that includes capturing biometric data from a user with an authentication device during authentication and directing illumination of the biometric data from a host authentication system during the capturing operation. Moreover, the method includes comparing illumination characteristics of the captured biometric data against illumination characteristics expected to result from the directing operation, and determining that the user is a live user when the illumination characteristics of the captured biometric data match the illumination characteristics expected to result from the directing operation. e. 24 20-- 8 00D0 0000 Network ILLUMINATION INSTRUCTIONS 28 1. Vary illumination over time 2. Project a detectable pattern 3. Vary position of illumination 4. Alter orientation of biometric data 5. Alter configuration of biometric data
Patent AU-2017279651-A1 (AU)
Title: Spectroscopic Analysis
Inventor: KROUSE DONAL PAUL
IPC: G01N21/17
Filed: 2017-12-20
Abstract: - 93 A method and analyser for identifying or verifying or otherwise characterising a sample comprising: using or having an electromagnetic radiation source for emitting electromagnetic radiation in at least one beam at a sample, the electromagnetic radiation 5 comprising at least two different wavelengths, using or having a sample detector that detects affected electromagnetic radiation resulting from the emitted electromagnetic radiation affected by the sample and provides output representing the detected affected radiation, and using or having a processor for determining sample coefficients from the output, and identifying or verifying or otherwise characterising the sample using the 10 sample coefficients and training coefficients determined from training samples, wherein the coefficients reduce sensitivity to a sample retainer variation and/or are independent of concentration. OD cr 1121 * * In M =t - 0D 4-4 ooEm . c (%J * I I I Ia mC
Patent AU-2017283277-A1 (AU)
Title: Synergistic effects, augmenting antimicrobial effects of lipids
Inventor: GIZURARSON SVEINBJORN
IPC: A01N37/02
Filed: 2017-06-19
Abstract: This invention relates to novel synergy, where the antimicrobial effects of microbicidal lipids are augmented with minor amounts of ethanol, in particular to augment the microbicidal effects for preventing infection in the nasal, ocular, otal, pharynx, larynx, sinuses, oral cavity, vaginal or dermal surface of a mammal by virus, pathogenic bacteria or fungi.
Patent AU-2017363265-A1 (AU)
Title: Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
Inventor: GRAY NATHANAEL S
IPC: C07D487/04
Filed: 2017-11-22
Abstract: The present application provides bifunctional compounds of Formula (X), or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for Bruton's tyrosine kinase (BTK). The present application also relates to methods for the targeted degradation of BTK through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BTK which can be utilized in the treatment of disorders modulated by BTK.
Patent AU-2017364328-A1 (AU)
Title: Method and apparatus for facilitating the operation of an on-site energy storage system to co-optimize battery dispatch
Inventor: Lee Ja-Chin Audrey
IPC: G05D17/00
Filed: 2017-11-15
Abstract: Various embodiments are provided for facilitating the operation and control of a fleet of on-site energy assets and optimizing energy dispatch across the fleet, thereby facilitating the use of the on-site energy assets instead of grid-supplied electric consumption. An example system may comprise a central platform and a plurality of on-site gateway devices configured to perform on-site asset control. An example method may comprise receiving a service availability call, performing fleet-level optimization, generating a set of site-level schedules, and causing, as a function of the site-level schedules, real-time on-site asset control. Other embodiments provide for determining a location of each grid-connected energy consumer at which to reduce grid-supplied energy consumption, determining an amount of a reduction of grid-supplied energy consumption, and transmitting a signal to each corresponding gateway device located at the determined location, the signal comprising data indicative of instructions for performing on-site energy dispatch.