baber/WOPTO huggingface dataset:
Patent BR-112014010206-B8 (BR)
Title: composto derivado de piridopirazina, composição farmacêutica, e, uso de um composto
Inventor: BRUNO ROUX
IPC: A61P35/00
Filed: 2012-10-26
Abstract: composto derivado de piridopirazina, composição farmacêutica, uso de um composto, e, produto. a invenção refere-se a novos compostos derivados de piridopirazina, às composições farmacêuticas que compreendem os ditos compostos, aos processos para a preparação dos ditos compostos e ao uso dos ditos compostos no tratamento de doenças, por exemplo, câncer.
Patent BR-112015021709-B8 (BR)
Title: Poli(beta-amino ésteres) modificados para administração de fármacos e nanopartícula compreendendo os mesmos, uma composição compreendendo os mesmos, método de encapsulamento de um agente em uma matriz de polímeros para formar nanopartículas, e uso dos poli(beta-amino ésteres)
Inventor: NATHALY SEGOVIA RAMOS
IPC: A61K38/00
Filed: 2014-03-10
Abstract: poli (beta-amino éster) es modificados para administração de fármacos descreve-se polímeros que são poli (beta-amino éster) es (pbaes) modificados com pelo menos um oligopeptídeo. os polímeros podem ser usados em qualquer campo onde os polímeros foram verificados como úteis, incluindo nos campos da medicina, particularmente na administração do fármaco. os polímeros são particularmente úteis na administração de um polinucleotídeo, tal como dna, rna e sirna, uma pequena molécula ou uma proteína. também são descritas composições que compreendem os referidos polímeros e um agente ativo, métodos de encapsulação de um agente em uma matriz dos referidos polímeros, e os referidos polímeros e composições para utilização em medicina.
Patent EP-1095696-B9 (EP)
Inventor: MARELLI ERNESTO
IPC: B01F5/06
Filed: 2000-10-09
Granted: 2005-04-06
Abstract: An apparatus and a method for forming stabilized atomized microemulsions from different liquids which are normally immiscible; the apparatus according to the invention comprises a primary chamber (C1) and a sequence of at least two cavitation chambers (C2-C5) arranged in succession, means for feeding primary and secondary fluids into the primary chamber (C1), and means for the exit of the formed microemulsion from the last cavitation chamber (C5), the primary chamber (C1) and the cavitation chambers (C2-C5) being fluid-connected to each other by way of fluid passage means which are adapted to produce a velocity of the fluids, during passage through the passage means, which gradually increases from the primary chamber (C1) toward the last cavitation chamber (C5). The method according to the invention comprises the stage of premixing the primary fluid with the secondary fluid, followed by the passage of the premix of fluids through a succession of steps of flow at a higher velocity alternated with steps of flow at a lower velocity, the higher flow velocities gradually increasing from the first higher-velocity step to the last higher-velocity step. <IMAGE>
Patent EP-1423105-B9 (EP)
Inventor: WILSON WILLIAM ROBERT
IPC: A61K33/243
Filed: 2002-09-03
Granted: 2009-08-12
Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compounds containing said combinations.
Patent EP-1509396-B9 (EP)
Inventor: GIORI FAUSTO
IPC: B41C1/05
Filed: 2003-06-03
Granted: 2009-09-16
Abstract: The invention relates to a system for manufacturing an engraved plate for intaglio printing of sheets of security papers, said system comprising a computer and at least one engraving tool controlled by said computer in accordance with a programmed engraving process, wherein said computer is programmed to control the engraving tool in accordance with three-dimensional guiding pixel data (X, Y, Z) of a master depth-map of one said sheet to engrave a non engraved plate pixel by pixel, and wherein said master depth-map is generated on said computer on the basis of at least one original depth-map stored on said computer, said original depth-map consisting of a three-dimensional raster image of at least a part of one said security paper. The invention also relates to a system and method for generating said guiding data.
Patent EP-2297195-B9 (EP)
Inventor: GIULIANI ANDREA
IPC: C07K14/47
Filed: 2009-06-02
Granted: 2012-05-09
Abstract: The present invention relates to monomeric and multimeric peptidic compounds which have antimicrobial activity, particularly against Gram-positive and Gram-negative bacteria. Further, the present invention refers to compositions comprising said peptidic compounds for medical use, for use as a disinfectant and/or detergent or for use as a preservative.
Patent EA-029775-B9 (EA)
Title: Use of a 1,3,5-triazin-2-yl phosphoramidate compound in the synthesis of sofosbuvir
Inventor: STEFKO MARTIN
IPC: C07F9/6558
Filed: 2015-04-15
Abstract: The present invention relates to a new type of 1,3,5-triazin-2-yl phosphoramidates of general formula I with the absolute configuration (S) at the phosphorus atom, an Sp diastereoisomer, wherein Rand Rcan independently be H, a C1-C6 (un)branched alkyl, a C1-C6 (un)branched alkoxy group, a C1-C6 (un)branched alkylsulfanyl group, C1-C6 (un)branched monoalkylamino or dialkylamino group, including cyclic amino groups, e.g. pyrrolidino, piperidino or morpholino group; and to their use for the production of biologically active phosphoramidate prodrugs, especially sofosbuvir of formula II. Sofosbuvir II is a nucleotide inhibitor of the RNA polymerase, used for the treatment of hepatitis C in the form of a prodrug, releasing the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-triphosphate in the organism.
Patent AU-2006257558-B9 (AU)
Title: Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof
Inventor: ZHANG LUPING
IPC: A61P25/00
Filed: 2006-06-16
Granted: 2012-02-02
Abstract: Compounds of the general formula (I), optical isomers, pharmaceutically acceptable salts, preparation process and uses thereof in which R1, R2, R3 and R4 are as defined in specification are disclosed. Such compounds can be optical isomers or racemic mixtures and can be metabolically transformated into 1-[2-dimethylamine-1-(4-hydroxyphenyl)-ethyl]cyclohexanol with new pharmaceutically active in vivo after administration, which can be used for treating diseases associated central nervous system such as depression et al. by interrupting reuptake of 5-hydroxytryptamine (5-HT ) and norepinephrine (NA ) .
Patent AU-2013315750-B9 (AU)
Title: Correctly folded etanercept in high purity and excellent yield
Inventor: ARAKAWA TSUTOMU
IPC: A61K38/16
Filed: 2013-09-10
Granted: 2018-11-15
Abstract: A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.
Patent DE-102006047218-B9 (DE)
Title: Vorrichtung und Verfahren zum zentralen Steuern von miteinander verbundenen Medizingeräten
IPC: H04L12/413
Filed: 2006-10-05
Granted: 2008-07-10
Abstract: Verfahren
zum Steuern mindestens einer Slave-Einrichtung (20a–c), die
als medizinisches Gerät
ausgeführt
ist, mittels einer Master-Einrichtung (10), die mit der Slave-Einrichtung
(20a–c)
verbunden ist, gekennzeichnet durch die Schritte:  Vorsehen
einer Slave-Einrichtung (20a–c)
als medizinisches Gerät,
in dem mindestens ein Darstellungsobjekt gespeichert ist, wobei
das mindestens eine Darstellungsobjekt mindestens ein Wiedergabeobjekt
(100, 120, 124, 130) mit wahrnehmbaren Eigenschaften des medizinischen
Geräts
umfasst, und  Übertragen
des mindestens einen Darstellungsobjekts der als medizinisches Gerät ausgeführten Slave-Einrichtung (20a–c) an die
Master-Einrichtung (10), die die wahrnehmbaren Eigenschaften des
medizinischen Geräts
darstellt.
Patent DE-102018107208-B9 (DE)
Title: Fahrzeugsteuerungsvorrichtung
Inventor: FUKAYA YUKI
IPC: B60W10/04
Filed: 2018-03-27
Granted: 2021-12-09
Abstract: Fahrzeugsteuerungsvorrichtung, die auf ein eigenes Fahrzeug (100) angewendet wird und Folgendes umfasst:ein adaptives Tempomatsteuerungsmittel zum Ausführen, als eine adaptive Tempomatsteuerung, einer Vorausfahrzeug-Hinterherfahrtsteuerung, die das eigene Fahrzeug (100) veranlasst, hinter einem vorausfahrenden Fahrzeug (200) herzufahren,das ein Fahrzeug ist, das vor dem eigenen Fahrzeug (100) fährt, durch Berechnen einer Zielbeschleunigung anhand einer Distanz zu dem vorausfahrenden Fahrzeug (200) und einer Relativgeschwindigkeit mit Bezug auf das vorausfahrende Fahrzeug (200), und Ausführen einer Beschleunigungssteuerung zum Beschleunigen des eigenen Fahrzeugs (100) und einer Verlangsamungssteuerung zum Verlangsamen des eigenen Fahrzeugs (100) so, dass eine Beschleunigung des eigenen Fahrzeugs (100) mit der Zielbeschleunigung übereinstimmt; undein Vor-Aufprall-Bremssteuerungsmittel zum Berechnen einer Zeit bis zur Kollision zu einem Zielobjekt, das in einer zuvor festgelegten Region positioniert ist, die eine Fahrtrichtung des eigenen Fahrzeugs (100) umfasst, anhand einer Distanz zu dem Zielobjekt und einer Relativgeschwindigkeit des Zielobjekts, und Bestimmen, dass eine Ausführungsbedingung für eine erste Bremssteuerung, die automatisch eine zuvor festgelegte erste Bremskraft an das eigene Fahrzeug (100) anlegt, erfüllt ist, wenn die Zeit bis zur Kollision weniger ist als eine zuvor festgelegte erste Schwelle, um die erste Bremssteuerung auszuführen,wobei:das adaptive Tempomatsteuerungsmittel ausgestaltet ist zum:Fortführen der Ausführung der adaptiven Tempomatsteuerung, wenn die Verlangsamungssteuerung zu einem Zeitpunkt ausgeführt wird, in dem bestimmt wurde, dass die Ausführungsbedingung für die erste Bremssteuerung während einer Ausführung der adaptiven Tempomatsteuerung erfüllt ist; undStoppen der Ausführung der adaptiven Tempomatsteuerung, wenn die Verlangsamungssteuerung nicht zu dem Zeitpunkt ausgeführt wird, undwobei das Vor-Aufprall-Bremssteuerungsmittel dafür ausgestaltet ist, die erste Bremssteuerung nicht auszuführen, wenn eine Ausführung der adaptiven Tempomatsteuerung in einem Fall fortgesetzt wird, in dem bestimmt wird, dass die Ausführungsbedingung für die erste Bremssteuerung während einer Ausführung der adaptiven Tempomatsteuerung erfüllt ist.
Patent BR-0202755-C1 (BR)
Title: aperfeiçoamentos em sistema de controle automático de altura de partes componentes de um equipamento
Inventor: DOMINGUES EDSON LUCIO
Filed: 2002-07-04
Abstract: "APERFEIçOAMENTOS EM SISTEMA DE CONTROLE AUTOMáTICO DE ALTURA DE PARTES COMPONENTES DE UM EQUIPAMENTO". A ser protocolado como Certificado de Adição de Invenção do pedido de patente PI 0202755-0, depositado em 04/07/2002, constituindo novas disposições e configurações de leitura dos sensores (3) ao longo das estruturas móveis (1) e (2) e de algoritmos na unidade de processamento de altura (4) que possibilitam filtrar a leitura de plantas invasoras altas na cultura, permitem identificar a altura do quadro central em relação ao solo ou plantação sem a necessidade de sensores (3) no quadro e também que permitem cruzar curvas de níveis com mais segurança e sem colisão das partes com o solo.
Patent DE-3114756-C1 (DE)
Title: Conveyor system for self-propelled conveyor trucks
Inventor: SCHLECKER HELMUT ING
IPC: B61B13/02
Filed: 1981-04-11
Granted: 1982-11-11
Abstract: The invention relates to a conveyor system for self-propelled conveyor trucks. The conveyor system permits conveyor trucks to be transported along track sections which extend from the horizontal plane into an oblique position or into the vertical plane. For this purpose, fixed toothed racks are provided at such sections of the track, with which a cog wheel of the conveyor truck drive engages. In each case a run-in toothed rack is mounted, viewed in the direction of transport of the conveyor trucks, in front of the toothed racks and is located in the transition region of sections of the track which extend in different planes. These run-in toothed racks have the object of transferring from the frictionally engaging wheel and disc drive used along horizontal sections of the track to positively engaging gear wheel drive. The run-in toothed racks are mounted for this purpose so as to be displaceable in the direction of transport and have means which restrict displacement of the run-in toothed rack away from the fixed toothed rack in such a way that the tooth pitch in the transition region of the run-in toothed rack with respect to the fixed toothed rack is constant. A non-synchronous run-in of the teeth of the gearwheel into the run-in toothed rack has the effect that, by virtue of its continuous displacement in the direction of transport of the conveyor, the gearwheel which is running onto a tooth of the run-in toothed rack initially displaces the run-in toothed rack in the direction of the fixed toothed rack until tooth engagement in a tooth gap of the run-in toothed rack is possible. When tooth engagement occurs, the run-in toothed rack is then displaced in the opposite direction until the tooth pitch in the transition region of the run-in toothed rack corresponds to the fixed toothed rack. As a result, the gearwheel can change from the run-in toothed rack to the fixed toothed rack without producing noise. <IMAGE>
Patent DE-3406217-C1 (DE)
Inventor: BANNING JUERGEN
IPC: D21F1/52
Filed: 1984-02-21
Granted: 1985-10-31
Abstract: Bei einer Doppelsiebpartie einer Papier- oder Kartonmaschine ist wenigstens ein Stütztisch, wie Entwässerungskasten o. dgl., vorgesehen, über den die Siebe laufen. Dem Stütztisch liegt auf der anderen Siebseite eine Führungsbahn gegenüber, welche aus dicht nebeneinanderliegenden Leisten gebildet ist. Diese sitzen mit ihrer siebabgewandten Seite auf einer elastischen Tragschicht und vermögen einzeln und/oder in Gruppen mit einstellbarem Druck Auslenkungen des zugeordneten Siebes zu folgen. Die aus Stütztisch und Siebführungsbahn gebildete Vorrichtung vermeidet Rückströmungen in der Suspension sowie Verdrückungen im Blattgefüge.
Patent DE-3408814-C1 (DE)
Title: Protective device for closure caps of bottles and jars
Inventor: FOLKERTS UWE
IPC: B62J6/20
Filed: 1984-03-10
Granted: 1985-06-05
Abstract: A protective device for closure caps of bottles and jars, in particular for screw closure caps and crown top caps. It consists of a protective hood made of thermoplastic material which has an elastically deformable protective collar which can be clamped onto the associated closure cap and a hood bottom which is constructed as a reflector. It has manipulating arms which are moulded onto the protective collar bends, are located diametrically opposite one another, are bent away from the protective collar and equipped with catch receivers for bicycle spokes and are thus equipped as attachment arms for attaching the protective device as a spokes reflector in a bicycle. <IMAGE>
Patent DE-3625674-C1 (DE)
Title: Device for transporting and depositing plants arranged in pots or the like
Inventor: GERNHOLT NORBERT
IPC: A01G9/08
Filed: 1986-07-29
Granted: 1987-05-27
Abstract: Published without abstract.
Patent DE-3718873-C1 (DE)
Title: Evaporative cooler
Inventor: MUSCHELKNAUTZ SEBASTIAN DIPL-I
IPC: F28D5/00
Filed: 1987-06-05
Granted: 1988-11-10
Abstract: A device for cooling heat generators in a space vehicle under weightlessness and with different accelerations consists of at least one heat exchanger with at least one active liquid coolant circulation, the heat exchanger being built in such a way that the initially at least partially still liquid coolant to be evaporated flowing through it experiences flow-mechanically induced inertial forces, which bring the unevaporated matter into contact with the heat transfer surface of the heat exchanger and consequently make possible almost complete conversion of the liquid coolant into its vapour phase. <IMAGE>
Patent DE-3723659-C1 (DE)
Title: Latching device for electrical switches
Inventor: SCHINDLER MICHAEL
IPC: H01H3/62
Filed: 1987-07-17
Granted: 1988-09-22
Abstract: A latching device is proposed for electrical switches having a latching curve which is located on the switch housing and defines different latching positions of the switch, and having a latching element which is assigned to the latching curve and is held on an adjustable switching element such that it can be deflected against the influence of a spring. In the case of this latching device, the switching noises are considerably reduced, while at the same time ensuring switching positions which can be identified in a marked manner for the user. This is achieved in that the latching element has at least one groove-like depression, filled with a sliding means, on its region which engages with the latching curve.
Patent DE-3736367-C1 (DE)
Inventor: MANUSCH CHRISTOPH
IPC: B43M11/06
Filed: 1987-10-27
Granted: 1989-02-23
Abstract: The device, suitable for use in a hand roller, for transferring a film from a carrier tape to a substrate is a cartridge containing a feed reel and a windup reel. The tape travels by way of a protruding stiff applicator bar which has a pressure-applying edge for pressing the tape against the substrate. The stiff applicator bar is on a spring support member which can be deflected until a protrusion on the bar encounters a detent fixed on the housing. The application bar has its pressure-applying edge appropriately shaped to facilitate the transfer action.
Patent DE-3737953-C1 (DE)
Title: Inhaler
Inventor: BUCHER HEINZ
IPC: A61M15/00
Filed: 1987-11-07
Granted: 1989-02-09
Abstract: The invention relates to an inhaler with a container for the reception of inhalation liquid in which the tip of a suction cone which can be induced to execute rotary movements by an electric motor dips into the inhalation liquid down to the bottom of the container and generates a spray zone in the region of its upper peripheral edge, in which an air inlet is provided over the suction cone and terminates in the region of the spray zone and in which the inhalation liquid mixed with the air sucked in via the air inlet is discharged as an aerosol via an aerosol outlet. A smaller handy design is obtained when the bottom of the container has a bearing sleeve for a drive shaft rotatably mounted therein, and when the suction cone designed as a hollow cone is provided with a plug connection starting from the tip and projecting into the interior space of the hollow cone. In this plug connection the drive shaft is fixed against rotation, and the drive shaft projects from the bottom of the container and can be driven directly or via coupling elements by the electric motor.
Patent DE-3911913-C1 (DE)
Title: Structural bearing in building - incorporates rolling surfaces of spherical or cylindrical shape
IPC: E04B1/36
Filed: 1989-04-12
Granted: 1990-06-13
Abstract: Structural bearing involves a spherical or cylinder shaped surface on the rolling bearing surfaces. The bearing bodies (10,17) should be made from ceramics and pretensioned at right angles to  the main loading direction (F). Pretensioning is pref. by mechanical methods or by shrinking the material under full surface load transfer between the casing side tensioners (13, 19) and bodies of the bearings (10, 17). USE/ADVANTAGE - Buildings, etc. chemical plant. Ceramic bearing bodies resist corrosion e.g. in desulphurising equipment, and are proof against elevated temp.
Patent DE-4121058-C1 (DE)
Title: Fibre=optic cable with stress-relieving sheath - has central core with several optical fibres, and outer sheath containing helical stress relief elements
IPC: G02B6/44
Filed: 1991-06-26
Granted: 1992-10-29
Abstract: The optical cable includes a lateral-pressure tight optical core with optical waveguide arranged around around it. Various stress-relieving elements (4) are embedded in the sheath (1) of the core element, and have a lay length which is from 0.5 up to 10.0 times greater than the dia. of the helix formed by twisting. Glass fibre reinforced plastics, steel wire etc. can be used for the stress-relief material. USE - Optical telecommunications cables.
Patent DE-4122942-C1 (DE)
Title: Plasma spray powder mfr. for fuel cell anode prodn. - by mixing nickel- and zirconium-oxide(s) with e.g. isopropanol, precalcining and coarsely comminuting
IPC: C23C4/10
Filed: 1991-07-11
Granted: 1992-01-30
Abstract: Plasma spray powder for use in mfr. of a fuel cell anode on a ceramic substrate, partic. of Y-stabilised Zr oxide, is mfd. from a mixture of 40-70 wt.% NiO and 60-30 wt.% ZrO2 with an additive, pref. isopropanol, which is homogenised by 4-48 hours wet milling and dried at 80 deg.C. The product is pre-calcined at about 1000 deg.C for 4 hours and coarsely comminuted by milling for 4 hours. After calcining at 1500-1600 deg.C for 1-4 hours the material is milled for 8 hours and sieved to give a powder in the size range 30-90 microns. ADVANTAGE - Powder is very adherent to the substrate.
Patent DE-4232375-C1 (DE)
Title: Radiator badge mounting for motor vehicle - has spherical socket bottom part of rubber or meshwork yielding on impact
Inventor: TOMFORDE JOHANN DIPL ING
IPC: B60R11/00
Filed: 1992-09-26
Granted: 1993-10-21
Abstract: The mounting is for a flat component protruding from the surface of a car body, e.g. a radiator badge. It has a spherical socket fixed to the surface and open to the top and accommodating a mating body pivoting in three directions and which is spring-loaded into it, the component being mounted on the body. The bottom part(2) of the socket(1) below the equatorial plane is of rubber, has an annular fracture line, or contains apertures(3) forming it into a meshwork, so that it yields on impact. The meshwork can be formed by spring tongues extending in the meridional direction and separated by apertures extending in the axial direction. ADVANTAGE - Reduces risk of injury on collision.
Patent DE-4236546-C1 (DE)
Inventor: BEHRENT HERMANN
IPC: H04B1/30
Filed: 1992-10-29
Granted: 1994-05-05
Abstract: The invention relates to a homodyne receiver and a method for direct conversion of angle-modulated carrier signals, particularly those which exhibit a direct-voltage component in the converted signal (ZF). In many types of modulation, the (short-time) DC component of the converted signal contains information on the modulating signal. Additional DC offsets produced are usually separated by using a bandpass filter for the intermediate-frequency signal (ZF). In this process, however, the DC components of the converted signal, which contain information, are lost as a result of which the demodulated signal is disturbed and, in particular, the harmonic distortion is increased. To avoid this, it is proposed that the local oscillator for generating I and Q signals has a different frequency from the carrier frequency of the received signal so that the difference frequency between carrier frequency and oscillator frequency is within the pass-band of the bandpass filters for suppressing unwanted mixed products, residual carrier and DC offsets. <IMAGE>