baber/WOPTO huggingface dataset:
Patent CA-2415840-A1 (CA)
Inventor: PLATTEEUW JOHANNES JAN
IPC: A61K47/00
Filed: 2003-01-08
Abstract: The invention relates to coated tamsulosin pellets and to unit dosage forms made therefrom. The invention provides a pharmaceutical dosage form comprising a plurality of pellets, wherein each pellet comprises: a. a pellet core having a diameter within the range of 0.3-0.9 mm and comprising a tamsulosin hydrochloride, microcrystalline cellulose, a pharmaceutically acceptable water permeable acrylic polymer and water; and b. an outer layer coat surrounding said core which comprises a pharmaceutically acceptable acid-resistant acrylic: polymer, wherein the mass of said outer layer coat, calculated on a dry pellet core basis, is within the range of 2.5-15%; and wherein the plurality of pellets exhibits a dissolution release profile in simulated gastric fluid using Ph. Eur. basket method at 100 rpm which includes releasing less than 100 of the tamsulosin during the first two hours. The invention also encompasses a process, which comprises: a. granulating a mixture of tamsulosin hydrochloride, microcrystalline cellulose, acrylic polymer, water and optionally auxiliary ingredients to form wet pellet cores, b. drying said wet pellet cores to a residual amount of water of 2-10%; c. sieving said dried pellet cores to obtain a fraction within the size range of 0.3-0.9 mm; d. coating said sieved dried pellet cores with a coating composition that comprises an acid-resistant water soluble acrylic polymer; and e. drying said coated pellet; wherein said coating step (d) is sufficient to provide said dried coated pellet with 2.5- 15 mass % of said coating composition, calculated on the dry pellet pore basis and a process, which comprises: (a) granulating a mixture of tamsulosin hydrochloride, microcrystalline cellulose, acrylic polymer, water and optionally auxiliary ingredients to form wet pellet cores, (b) drying said wet pellet cores to a residual amount of water of 2-10%; sieving said dried pellet cores to obtain a fraction within the sire range of: 0.3-0.9 mm; (c) coating said sieved dried pellet cares with a coating composition that comprises an acid-resistant water soluble acrylic polymer; (d) drying said coated pellet; (e) testing a sample of said dried coated pellets for dissolution rate in a simulated gastric fluid; and (f) repeating the coating process on the remaining dried coated pellets until a desired amount of release is achieved in said testing step (e).
Patent CA-2418725-A1 (CA)
Inventor: WILEY STEVEN R
IPC: A61P13/12
Filed: 2001-08-15
Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
Patent CA-2419064-A1 (CA)
Title: Kruppel-like factor 6 (klf6), a tumor suppressor protein, and diagnostics, therapeutics, and screening based on this protein
Inventor: MARTIGNETTI JOHN
IPC: C12Q1/6886
Filed: 2001-08-09
Abstract: The present invention relates to identification of tumor suppressor activity  of a protein, KLF6 (KLF6), and to related diagnostic and therapeutic compositions and methods. The discovery of this tumor suppressor activity provides screening targets as well, particularly screening for compounds tha t overcome gene inactivation or alteration.
Patent CA-2420288-A1 (CA)
Title: 2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones with an anticonvulsive action and methods for producing the same
Inventor: DOST RITA
IPC: A61P25/08
Filed: 2001-08-24
Abstract: The invention relates to 2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones and their tautomers, containing an ar(alkyl) radical in position 5 and a hydrogen or an ar(alkyl) radical in position 2; to methods for producing them and to their use as medicaments, especially for treating different kinds of epilepsies.
Patent CA-2422198-A1 (CA)
Title: Substituted hydrazine derivatives
Inventor: BRUNDEN KURT R
IPC: A61P25/28
Filed: 2001-09-07
Abstract: A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.
Patent CA-2425984-A1 (CA)
Inventor: HAN SHIDONG
IPC: C07D239/60
Filed: 2001-09-13
Abstract: This invention relates to new 2-pyrimidinyloxy-N-aryl-benzylamine derivatives, their preparation processes and uses as chemical herbicides in agriculture. The compound has the following structure:   (see formula I) wherein, D or E is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy; R1 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 carbamoyl C1-C4 alkoxycarbonyl, C1-C4 haloalkyl, cyano, nitro, carboxy or its alkali metal, alkali earth metal and organoammonium salts, C1-C4 alkylamido, C1-C4 haloalkylamido, heterocyclic amido, benzamido or substituted benzamido, benzo or substituted benzo compounds; R3 is hydrogen, C1-C4 alkanoyl, C1-C4 haloalkanoyl, benzoyl or C1-C4 alkoxyacetyl; X is CH or N;  n=1-3.
Patent CA-2427033-A1 (CA)
Inventor: WISCHERHOFF ERIK
IPC: G01N33/543
Filed: 2001-10-24
Abstract: The invention relates to products comprising a solid surface, a multilayer system of at least two covalently interconnected layers of a polymeric material covalently attached to said surface, and a biofunctional layer covalently attached to said multilayer system. The biofunctional layer may comprise a bioactive ingredient to make the product useful for numerous applications, such as biosensors, implants, sample containers, affinity sensor arrays and affinity chromatography media. The invention also relates to methods for making such products. The use of a multilayer system of organic polymers allows to obtain almost identical biofunctional surfaces on very different substrates and provides a more complete shielding of the original surface of the substrate which reduces non-specific absorption of biomolecules.
Patent CA-2427261-A1 (CA)
Title: Aged companion pet diet
Inventor: WEDEKIND KAREN J
IPC: A23K1/16
Filed: 2001-10-30
Abstract: A companion pet diet meeting ordinary nutritional requirements for an aged pet and further comprising a sufficient amount of antioxidant or mixture thereof, to inhibit the deterioration of the mental capacity of an aged companion pet.
Patent CA-2427944-A1 (CA)
Inventor: WILHELM HENRI
IPC: C01B31/04
Filed: 2002-10-01
Abstract: Cette pile électrochimique comporte une électrode positive contenant du dioxyde de manganèse électrolytique, du dioxyde de manganèse chimique, des manganates, des cobaltates ou des nickelates lithiés comme adjuvants de conductivité, tel que caractérisés en (1). L'invention concerne également une pile électrochimique possédant une électrode positive contenant du dioxyde de manganèse électrolytique, du dioxyde de manganèse chimique, des manganates, des cobaltates ou des nickelates lithiés comme composants électro-actifs et du graphite comme adjuvant de conductivité, lequel se caractérise par le fait qu'il renferme au moins du graphite expansé par voie thermique sous sa forme vermiculaire. Le degré d'expansion de la particule initiale de graphite dans le sens Z de la particule est supérieur à 80 fois sa dimension Z initiale et est compris, de préférence, entre 200 et 500 fois cette dimension Z initiale.
Patent CA-2430979-A1 (CA)
Title: Method and apparatus for vacuum forming films
Inventor: RUEHL KENNETH LEONARD
IPC: B65B9/04
Filed: 2002-01-31
Abstract: The present invention is directed to a process and apparatus for forming a film. The film is then thermoformed into pouches which are filled and sealed in a sequential operation. The process comprises the steps of (a) supplying a thermoformable film to an upper surface of a conveyer which includes a plurality of recessed vacuum moulds in its upper surface and is mounted to slide over an elongated conveyor support through holding, forming, filling and sealing stations; (b) holding the film on the conveyer at the holding station; (c) forming the film to form pouches at the forming station by supplying a forming under-pressure at the forming station into the vacuum moulds wherein the forming under-pressure is supplied through vacuum apertures leading from a vacuum supply apparatus and discharging through the conveyer support through vacuum orifices extending through the conveyer into the vacuum moulds, wherein under-pressure is supplied to the vacuum moulds at one or more subsequent processing stations through the vacuum apertures and vacuum orifices, and wherein the under pressure at the forming station is greater than the under-pressure at one or more of the subsequent processing stations; (d) filling the pouches at the filling station; and (e) sealing the pouches with a scaling film at the sealing station; wherein an under-pressure that is greater than substantially zero is supplied at all of the subsequent processing stations.
Patent CA-2431556-A1 (CA)
Title: A nuclear power plant and method of operating the same
Inventor: KRIEL WILLEM ADRIAAN ODENDAAL
IPC: F02C1/05
Filed: 2002-03-25
Abstract: A method of regulating the power generated in a nuclear power plant which includes the step of regulating the flow of helium through the reactor. To this end, the power plant includes a closed loop power generation circuit having at least one compressor and a recirculation circuit whereby helium can be recirculated around the compressor. By regulating the flow of helium around the recirculation circuit using suitable valves the flow of helium through the reactor and hence the power generated can be regulated. The plant includes a helium inventory control system whereby the inventory of helium in the power generation circuit can be varied thereby varying the power generated in the circuit.
Patent CA-2431986-A1 (CA)
Title: Use of activated coagulation factor vii for treating thrombolytic therapy-induced major bleedings
Inventor: WIENEN WOLFGANG
IPC: A61K38/00
Filed: 2001-12-20
Abstract: Major bleedings induced by thrombolytic/fibrinolytic therapy, including intracranial haemorrhages, are treated by adminstering to a subject sufferin g from such bleedings an effective amount of activated coagulation factor VII (VIIa) or of a functional derivative thereof.
Patent CA-2439605-A1 (CA)
Inventor: MONTEBRUNO LIDIA
IPC: H04W84/20
Filed: 2002-03-06
Abstract: L'invention concerne un réseau de télécommunication pour utilisateurs mobiles (UNET). Ledit réseau comprend un sous-système d'utilisateur (STU) et un sous-système de transport (STT) connecté au moyen d'un sous-système d'accès (STA) qui leur offre respectivement une interface de communication d'accès utilisateur (Uu) et une interface de communication d'accès de transport (Iu) permettant d'échanger des flux d'informations (TS) entre lesdits sous-systèmes. Ledit sous-système d'accès (STA) identifie une zone de couverture de réseau de téléphone cellulaire. Conformément à la présente invention, ledit sous-système d'accès (STA) est associé à des moyens d'interconnexion (GSB, NGS) afin de recevoir des flux d'informations secondaires (BS) émis par un ou plusieurs satellite(s) géostationnaire(s) (GS) et les envoie par le réseau de télécommunication pour utilisateurs mobiles (UNET), lesdits moyens d'interconnexion (GSB, NGS) étant situés dans la zone de couverture dudit réseau de télécommunication mobile (UNET).
Patent CA-2442540-A1 (CA)
Inventor: NARJES FRANK
IPC: C07K5/083
Filed: 2002-03-26
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts and esters thereof: (I); wherein Q, R2, X, Y and Z are as defined herein; are inhibitors of the hepatitis C virus (HCV) NS3 protease.
Patent CA-2445891-A1 (CA)
Title: Construction for routing a conduit or the like through a structural member
Inventor: BROWN PHILIP ANDREW
IPC: F16L5/10
Filed: 2002-05-23
Abstract: This invention relates to a construction for fitting to a structural member in particular to a construction for routing a conduit or the like through a structural member where the integrity of the seal made by the structural member must be maintained. The construction having an annular bush (50) for fitting tightly in an aperture (43) defined in a structural member, the annular bush (50) being expandable radially when located in the aperture (43) by the action of a mandrel being passed through a longitudinal passageway defined by the bush whereby to exert a compressive force upon the region of the structural member surrounding the bush (50), wherein the bush (50) has a coupling for sealable attachment of a conduit to the bush (50).
Patent CA-2446699-A1 (CA)
Inventor: SJOEBERG AKE
IPC: B44C/
Filed: 2002-05-03
Abstract: Embossed decorative boards (1) having a first and a second opposite edge (1I  and 1II respectively) with a third and a fourth adjacent edge (1III and 1IV  respectively). The board (1) include an upper side decorative surface (2) an upper side embossing and a base layer. The embossing is comprised by surface structure areas (10) of which at least four are first and second outermost surface structure areas (10L and 10R respectively). The first outermost surface structure areas (10L) has each one end edge coinciding with the first edge (1I) of the board (1) while the second outermost surface structure areas (10R) has each one end edge coinciding with the second edge (1II). At least two surface structures having different visual characteristics is used, wherein two adjacent outermost surface structure areas (10L and 10R  respectively) within the same board (1) has different surface structures. The first outermost surface structure areas (10L) of the first edge (1I) is numbered LI, LII, LIII etc. in a subsequent order starting from the third edge (1III) while the second outermost surface structure areas (10R) of the second edge (1I) is numbered RI, RII, RIII etc. The end edge of the outermost surface structure areas (10L and 10R respectively) with the same ordinal number of the first edge (1I) and the second edge (1II) has mainly the same length while of the surface structure is similar.
Patent CA-2447384-A1 (CA)
Inventor: KRUSHKA PAUL ANTHONY
IPC: A63F3/06
Filed: 2002-05-16
Abstract: An electronic game player (1) for playing bingo, keno and other similar games stores information corresponding to information on at least one game ticket for the game being played. The game player (1) comprises a keypad (4) for entering numbers into the game player via a single keystroke and for performing other functions (13-16) relating to the game. The game player (1) further comprises a screen (5) for displaying data relating to the game and the components of the game player are accommodated in a hand-held housing (1a).
Patent CA-2450063-A1 (CA)
Inventor: AMUNDSON ROBERT
IPC: B60S9/12
Filed: 2003-12-12
Abstract: A trailer with mechanically activated dolly legs includes a trailer body having a front towing end and a rear end.      Ground engaging support wheels are positioned at the rear end.      Means are provided for attachment to a tow vehicle at the front towing end. Dolly legs are positioned spaced from and underlying the front towing end. The dolly legs are housed in a housing and are movable relative to the housing between an extended position and a retracted position. At least one air bag is positioned between the dolly legs and the housing. The air bag is adapted to move the dolly legs from the retracted position to the extended position.
Patent CA-2451910-A1 (CA)
Inventor: HOLT BRIAN
IPC: H04W64/00
Filed: 2002-06-20
Abstract: A system and method determines the location of a transmitter. At least one receiver receives a signal from the trasmitter(64) and at least one proxy receiver is an object that reflects and /or refracts a signal along an arriving path to the at least one receiver. A processor(66) is operative wit h the at least one receiver and determines the location of the at least one proxy receiver based on one of querying a look-up table or extracting image features from the mapping system and determining the location of the trasmitter based on the time of arrival and at least one of angle of arrival of signals from the at least one proxy receiver and transmitter.
Patent CA-2452140-A1 (CA)
Title: An improved aerosol actuator
Inventor: HENNESSY FERGAL
IPC: B65D83/40
Filed: 2002-06-26
Abstract: A metered dose aerosol actuator having a generally cylindrical housing (1) which includes a mouthpiece (2). The housing includes a stem block (5) for receiving and seating a valve stem (4) of a pressurized medicament container.  The stem block includes an internal cavity (6) provided with an outlet channel (7) which terminates on the external surface of the stem block with a spray orifice (9) which is directed towards the mouthpiece. The valve stem, internal cavity, outlet channel and spray orifice form a continuous path.
Patent CA-2452234-A1 (CA)
Inventor: NAKAMURA NAOMICHI
IPC: B22F1/08
Filed: 2003-12-08
Abstract: This invention provides a metal powder for powder magnetic cores, which have good insulation performance and high magnetic flux density, and which is favorable for motor cores. Ferromagnetic metal powder may be coated with a coating material and a phosphate or phosphoric acid compound containing aluminum is used for the coating material.  Coating the surface of iron powder with aluminum phosphate realizes to produce high-quality powder magnetic cores that have good insulation performance and high magnetic flux density and are favorable for motor cores. Further coating the aluminum phosphate-coated metal powder with silane compound or surfactant realizes more stable compressed shaped articles of the powder. And the properties of the articles do not fluctuate while stored for, so long as they are resistant to moisture. This invention contributes to producing powder magnetic cores for motors, and to the process for powder magnetic cores, furthermore, to the related art field.
Patent CA-2452690-A1 (CA)
Inventor: PEARCE CHRISTOPHER D J
IPC: C12Q1/6837
Filed: 2002-06-28
Abstract: L'invention concerne un microréseau d'anticorps comprenant une pluralité d'anticorps immobilisés sur un substrat, chaque anticorps se liant spécifiquement à un oligomère synthétique (p. ex. un oligonucléotide ou un oligopeptide) auquel est lié un groupe protecteur organique de façon covalente, l'anticorps ne se liant pas à cet oligomère synthétique si le groupe protecteur organique n'est pas lié de façon covalente à celui-ci. L'invention concerne par ailleurs des procédés de production et d'utilisation de ces anticorps, ainsi que des cellules pour produire ces anticorps. L'invention concerne enfin des procédés de production et d'utilisation de ce type de microréseau d'anticorps.
Patent CA-2454815-A1 (CA)
Title: Composite utility knife blade, and method of making such a blade
Inventor: KORB WILLIAM B
IPC: B26D1/00
Filed: 2002-07-24
Abstract: A composite utility knife blade (10) and method of making such a blade involves butt joining a tool steel wire (44) to a front edge of an alloy steel backing strip (34). The wire (44) is electron beam welded to the backing strip (34) to form a composite strip (46) defining a first metal portion (20) formed by the alloy steel backing strip (34), a second metal portion (22) formed by the tool steel wire (44), and a weld region (28) joining the first and second metal portions (20, 22). The composite strip (46) is then annealed, and the annealed strip is straightened to eliminate any camber therein. The annealed composite strip (46) is then hardened such that the first metal portion (20) defines a surface hardness within the range of approximately 38 Rc to approximately 52 Rc, and the second metal portion (20) defines a surface hardness within the range of approximately 60 Rc to approximately 75 Rc.
Patent CA-2455830-A1 (CA)
Inventor: LOEB JEFFREY A
IPC: C07K19/00
Filed: 2002-07-31
Abstract: L'invention concerne des polypeptides du domaine se liant à l'héparine (N-HBD) de neuréguline (NRG) et des acides nucléiques les codant. En particulier, des polypeptides de fusion, qui sont produits, comportent, comme structure de ciblage, un polypeptide N-HBD, un fragment, un homologue ou un dérivé fonctionnel et une protéine à cibler fusionnant à un polypeptide ou peptide ciblant (P¿trg?) des surfaces cellulaires riches en protéoglycanes de sulfate d'héparane afin d'activer ou d'inhiber des interactions au niveau des récepteurs de tyrosine kinase. De tels produits servent dans le traitement de maladies ou d'états où l'agonisme ou l'antagonisme au niveau des récepteurs de tyrosine kinase présente des effets bénéfiques, notamment dans le cas des cancers et de nombreuses maladies du système nerveux.
Patent CA-2456975-A1 (CA)
Inventor: SMITH ALEX
IPC: G21H7/00
Filed: 2004-02-24
Abstract: Shined a flashlight on a distant galaxy. Seen a flashlight shine back. Pointed another direction, and seen other flashlights on different angles. This proved the galaxies are all the same.
Patent CA-2457681-A1 (CA)
Title: Fibres colorees par procede cationique et articles les contenant
Inventor: SKIDDS RONALD O
IPC: D03D15/00
Filed: 2002-12-03
Abstract: L'invention concerne des fibres colorées à gaine / noyau contenant du polyamide. En outre, elle concerne des procédés de fabrication des fibres colorées à gaine / noyau contenant du polyamide et des articles comprenant lesdites fibres colorées à gaine / noyau contenant du polyamide.
Patent CA-2460525-A1 (CA)
Title: Fluid skin friction sensing device and method
Inventor: ZISK EDWARD J JR
IPC: E21B47/10
Filed: 2002-09-20
Abstract: The apparatus includes a signal sensing demodulator device and a skin friction sensing device positionable within the wellbore. Both devices are in informational communication with each other. The method includes exposing the skin friction sensing device to a fluid flow, transmitting a signal obtained as a result of a movement of the skin friction sensing device from the fluid flow to a signal sensing demodulator device, converting the signal to a numerical value, and computing a parameter or parameters of the fluid flow in the wellbore from the numerical value.
Patent CA-2461402-A1 (CA)
Title: Wellhead and control stack pressure test plug tool
Inventor: MCGUIRE BOB
IPC: E21B47/10
Filed: 2004-03-12
Abstract: A test plug tool for use in testing a pressure integrity of a pressure control stack mounted to a wellhead, including a joint between a casing and a casing support in the wellhead. The test plug tool includes a test plug of an appropriate diameter used to pressure test the pressure control stack as well as a joint between any one of a surface casing and the wellhead, an intermediate casing and an intermediate casing mandrel, and a production casing and a production casing mandrel. The pressure integrity of the wellhead is ensured at each stage of well drilling and well completion, and safety is improved. Optionally, a backpressure valve permits pressurized fluid that leaks below the test plug tool to flow upwardly through a central bore in a landing tool that is secured to the test plug tool to permit detection of the leak.
Patent CA-2463668-A1 (CA)
Title: Compositions and kits comprising a defined boron compound, methods of their preparation, and use and administration thereof
Inventor: NIEHOFF RAYMOND LOUIS
IPC: A23L33/00
Filed: 2002-11-15
Abstract: The present disclosure is directed to compositions containing boron which ar e useful for a variety of purposes, including enhancing bone health, alleviati ng arthritis, pain, and inflammation, and producing other beneficial health effects. The disclosure is further directed to methods of preparing such compositions, methods of using (including administering) the compositions, a nd kits comprising the compositions. The compositions have a pH which is at lea st about 2 pH units less than the pKa of the boron compound.