Patent SG-11201807465R-A (SG)
Title: Lipid biomarkers for the diagnosis of cancer
Inventor: HO YING SWAN
IPC: G01N33/92
Filed: 2017-03-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111011100111011111001111101111011111 International Bureau 0.. .... .. (10) International Publication Number ...... ... (43) International Publication Date WO 2017/155473 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; G01N 33/92 (2006.01) P.O. Box 1531, Robinson Road Post Office, Singapore (21) International Application Number: 903031 (SG). PCT/SG2017/050120 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 10 March 2017 (10.03.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 10201601873S 10 March 2016 (10.03.2016) SG NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicants: AGENCY FOR SCIENCE, TECHNO- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, LOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, ZA, ZM, ZW. #20-10 Connexis North Tower, Singapore 138632 (SG). SINGAPORE HEALTH SERVICES PTE LTD (84) Designated States (unless otherwise indicated, for every [SG/SG]; 31 Third Hospital Avenue, #03-03 Bowyer kind of regional protection available): ARIPO (BW, GH, Block C, Singapore 168753 (SG). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, _ (72) Inventors: HO, Ying Swan; c/o Bioprocessing Techno- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, logy Institute, 20 Biopolis Way, #06-01 Centros, Singapore DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — _ 138668 (SG). YIP, Lian Yee; c/o Bioprocessing Techno- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, logy Institute, 20 Biopolis Way, #06-01 Centros, Singapore SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 138668 (SG). LIM, Kiat Hon Tony; c/o Singapore Gener- GW, KM, ML, MR, NE, SN, TD, TG). = al Hospital, Department of Pathology, 20 College Road, Academia, Level 7, Singapore 169856 (SG). TAN, Shao Declarations under Rule 4.17: Weng Daniel; c/o National Cancer Centre, 11 Hospital — of inventorship (Rule 4. 17(iv)) Drive, Singapore 169610 (SG). YANG, Xulei; c/o Institute of High Performance Computing, 1 Fusionopolis Way, Published: = #16-16 Connexis North Tower, Singapore 138632 (SG). — with international search report (Art. 21(3)) YEO, Si Yong; c/o Institute of High Performance Comput- ing, 1 Fusionopolis Way, #16-16 Connexis North Tower, Singapore 138632 (SG). = = = = = = = = = 1-1 M IN 7r 11 in 11 in ,—, (54) Title: LIPID BIOMARKERS FOR THE DIAGNOSIS OF CANCER C 1-1 (57) : The present disclosure provides lipid biomarkers from pleural effusion samples and use thereof in a method for de - el termining whether a patient suffering from pleural effusion has cancer, or in a method for treating cancer in a patient suffering from en. ) pleural effusion. Also disclosed herein is the use of lipid biomarkers from pleural effusion samples in a method for determining whether a patient suffering from pleural effusion has cancer with EGFR mutation, and in a method for treating cancer in a patient 5.- with EGFR mutation.