Patent SG-11201906938W-A (SG)
Title: Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
Inventor: SCHULTZ KIMBERLY
IPC: A61B5/00
Filed: 2018-01-30
Abstract: PREPROCESSING SUBUNIT POST-AGENT ADMINISTRATION SELECTION SUBUNIT RDTC CALCULATION FAULT DETECTION SUBUNIT SUBUNIT PROCESSING UNIT 1308 ) 1304 ) 1306 ) BACKGROUND SUBTRACTION SUBUNIT BACKGROUND CORRECTION SUBUNIT 1310 ) 1312.. (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT onion °nolo olomoiloimoinomo oimIE (10) International Publication Number WO 2018/140978 Al • (57) : A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium GC with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measure- ment entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. © The measurements may include one or more of: a DR ex signal detected by an unfiltered light detector during illumination by excitato- 71' 1-1 (51) International Patent Classification: A61B 5/00 (2006.01) GO1N 21/64 (2006.01) G01N 21/62 (2006.01) (21) International Application Number: PCT/US2018/016041 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,025 30 January 2017 (30.01.2017) US (71) Applicant: MEDIBEACON INC. [US/US]; 1100 Corpo- rate Square Drive, Suite 175, St. Louis, Missouri 63132 (US). (72) Inventors: SCHULTZ, Kimberly; 238 Mercy Street, Mountain View, California 94041 (US). KEATING, Jen- nifer; 1631 Mercy Street, Apt. B, Mountain View, Cali- fornia 94041 (US). SOLOMON, Edward; 1110 Orange Avenue, Menlo Park, California 94025 (US). BECHTEL, Kate; 107 Hardy Circle, Pleasant Hill, California 94523 (US). (74) Agent: MCCAY, Michael, G. et al.; Armstrong Teas- dale LLP, 7700 Forsyth Boulevard, St. Louis, Missouri 63105-1847 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: METHOD FOR NON-INVASIVE MONITORING OF FLUORESCENT TRACER AGENT WITH DIFFUSE REFLEC- TION CORRECTIONS 236 FIG. 13 ry-wavelength light from first region adjacent to the diffuse reflecting medium; a signal detected by a filtered light detector during Flr illumination by excitatory-wavelength light; and a signal detected by the unfiltered light detector during illumination by emis- DR em rl light. The method further includes identifying a post-agent administration portion of the measurement data set; and © • transforming each Flr signal to an signal representing a detected fluorescence intensity emitted solely by the fluorescent agent. IF C [Continued on next page] WO 2018/140978 Al MIDEDIMOMMIONER13010M01101MOMODEVOIMIE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))