baber/WOPTO huggingface dataset:
Patent NZ-277086-A (NZ)
Title: Vitamin d amine and amide derivatives and medicaments
Inventor: HESSE ROBERT HENRY
IPC: A61P25/28
Filed: 1994-12-13
Abstract: PCT No. PCT/GB94/02725 Sec. 371 Date Jul. 31, 1996 Sec. 102(e) Date Jul. 31, 1996 PCT Filed Dec. 13, 1994 PCT Pub. No. WO95/16672 PCT Pub. Date Jun. 22, 1995The invention relates to vitamin D amine and amide derivatives of general formula    <IMAGE>  (I)  where R represents a hydrogen atom, an aliphatic, cycloaliphatic or araliphatic group, or an acyl group comprising an aliphatic, cycloaliphatic, arylaliphatic or aryl group linked to the nitrogen atom by way of a carbonyl group; R1 and R2 are each selected from lower alkyl and cycloalkyl groups or together with the carbon atom to which they are attached form a lower cycloalkyl group; R3 represents a methyl group having  alpha - or  beta -configuration; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; and A= represents a cyclohexylidene moiety characteristic of the A-ring of a 1  alpha -hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit cell modulating activity and in certain cases may also have an effect on calcium metabolism. The compounds of the invention may be prepared by isomerizing a 5,6-trans isomer of formula (I) to a corresponding 5,6-cis isomer; by hydroxylating a 1-unsubstituted-5,6-trans analogue of a compound of formula (I) to prepare a 5,6-trans isomer of formula (I); by reacting a compound containing a precursor for the desired 17-position side chain in one or more stages and with one or more reactants serving to form the desired side chain; or by reacting a compound of formula (I) to modify the substitution pattern about the A= group.
Patent NZ-297364-A (NZ)
Title: Soft antibacterial liposomes of neutral & anionic phospholipids
Inventor: LAGACE JACQUELINE
IPC: A61K31/7028
Filed: 1995-12-22
Abstract: he invention relates to a liposomal formulation containing at least one therapeutic agent such as an antibiotic and to a method of treatment of bacterial infections through the administration of such a formulation. There is provided a low rigidity multilamellar liposomal formulation, free of cholesterol, comprising a neutral lipid, an anionic lipid and at least one therapeutic agent, wherein the liposomal formulation enhances the penetration of the therapeutic agent inside a bacterial cell. A preferred lipid combination is dipalmitoylphosphatidylcholine (DPPC): dimirystoylphosphatidylglycerol (DMPG) at a ratio of 10:1 to 15:1, with total lipid concentration ranging from 5 to 85 mM.  Divisional filed as 501648
Patent NZ-311383-A (NZ)
Title: Improved inflatable device for use in surgical protocols relating to treatment of fractured or diseased bone
Inventor: REILEY MARK A
IPC: A61F2/958
Filed: 1996-06-06
Abstract: pparatus, for delivering a therapeutic substance to a treatment site within a bone, includes a body comprising a wall having an outer surface capable of expansion from a collapsed configuration to an expanded configuration to compress cancellous bone.  The wall includes a material that is capable of restraining expansion.  A therapeutic substance is arranged on the body to be compacted by the body into cancellous bone compressed by the wall.  Figure 3 shows apparatus 109 comprising three inflatable balloon units 110, 112, 114 which have restraints 117 to limit expansion in a direction transverse to the longitudinal axes of the units.  A tube system 115 is provided to direct liquid under pressure into the units and so that fluid can be used to inflate the units when placed inside bone in a deflated state.  The restraints keep opposed sides 77, 79 substantially flat and parallel with each other.  The therapeutic substance may include a chemotherapeutic agent, an osteoporosis drug or a growth factor.
Patent NZ-318940-A (NZ)
Title: Computerised trading system with hittable quotes on nominated floors
Inventor: HOWORKA EDWARD R
IPC: G06Q40/04
Filed: 1996-08-28
Abstract: For each quote entered into a computerized anonymous trading system, the system determines if it is waiting to be "hit" (would be matched with the first hit of a predetermined size) at a substantial number of trading floors, and if so, notifies the trader originating the quote. The substantial number of floors is preferably expressed as greater than a predetermined percentage of the available trading partners with whom credit has been established on a bilateral basis, and is preferably greater than 25%. In an alternate embodiment, the system provides a graphical display to the market maker originating a particular quote indicating how many trading floors are poised to hit that particular quote, and/or a numeric display indicating a price that would be Hittable by a predetermined number or percentage of available trading partners.
Patent NZ-319090-A (NZ)
Title: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
Inventor: BELLEY MICHEL
IPC: C07D307/94
Filed: 1996-10-09
Abstract: (57)	 The invention encompasses the compounds of above formula (I) as depicted above which are useful in the treatment of cyclooxygenase-2 (COX-2) mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the above compounds.   Divisional filed as 332820
Patent NZ-321820-A (NZ)
Title: Stable highly active compositions of avidin with an inert support material (agar) a bulking agent and a protectant for separation
Inventor: BURTON STEVEN J
IPC: A61L24/10
Filed: 1996-10-28
Abstract: Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance wherein avidin, agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants.
Patent NZ-329762-A (NZ)
Title: Draining wall comprises panels filled with a filtering material separated by intermediate elements
Inventor: DENIAU ALAIN
IPC: F16L1/038
Filed: 1997-06-25
Abstract: PCT No. PCT/FR97/01136 Sec. 371 Date Feb. 19, 1998 Sec. 102(e) Date Feb. 19, 1998 PCT Filed Jun. 25, 1997 PCT Pub. No. WO97/49871 PCT Pub. Date Dec. 31, 1997A draining wall comprises a plurality of elementary panels (P) filled with a filtering material (10), wherein the panels are separated from one another by intermediate elements (J) and in that an element (2) connecting each pair of adjacent panels is embedded in the lower part of each intermediate element. The application also discloses a method and an element for its implementation. The invention is particularly useful for landslide areas.
Patent NZ-332255-A (NZ)
Title: Use of herpes simplex virus glycoprotein d variants
Inventor: COHEN GARY H
IPC: A61K38/00
Filed: 1998-10-08
Abstract: A method for inhibiting the infection of susceptible non-human cells by herpes simplex virus is described. The method involves contacting the cells with a composition that comprises an acceptable carrier and a variant molecule selected from the following: (a) a variant herpes simplex virus glycoprotein D molecule comprising amino acids 1-300 of SEQ ID NO:2 (as defined in the specification), (b) the variant molecule of (a) further comprising amino acids -2 and -1 of SEQ ID NO:2, (c) the variant molecule of (a) further comprising amino acids 301-306 of SEQ ID NO:2 and (d) a gD-1(?290-299t) molecule comprising amino acids -2 to306 of SEQ ID NO:2.
Patent NZ-333355-A (NZ)
Title: Electrical circuit breakers
Inventor: LANE STEPHEN ERNEST
IPC: H01H77/10
Filed: 1997-07-04
Abstract: PCT No. PCT/GB97/01805 Sec. 371 Date Dec. 14, 1998 Sec. 102(e) Date Dec. 14, 1998 PCT Filed Jul. 4, 1997 PCT Pub. No. WO98/01883 PCT Pub. Date Jan. 15, 1998An electrical circuit breaker includes a moveable contact piece connected to an actuating means and provided with a contact face arranged to make contact with a contact face of a second contact piece by movement of the moveable contact piece generally in a first direction. The circuit breaker further includes an electrical connector for conveying current to the moveable contact piece which includes at least two adjacent limbs adapted to convey the current in opposing directions so as to generate an electromagnetic force repelling the adjacent limbs from one another, which force is used to assist in maintaining the contact faces in abutment. The outermost limbs bear, respectively, upon a reaction end face of the actuating means and the moveable contact piece, and the moveable contact piece is connected to the actuating means by a connecting rod displaceable relative to the actuating means and biased in the first direction so as to form a snatch gap between the actuating means and the connecting rod when the first and second contact pieces are closed, the electromagnetic force thereby assisting in accelerating closure of the snatch gap during a contact opening operation.
Patent NZ-333907-A (NZ)
Title: Cleavable optically detectable elements on substrate for microanalysis of chemical species
Inventor: VIRTANEN JORMA
IPC: C12Q1/68
Filed: 1997-07-08
Abstract: A cleavable signal element for use in quantitative and qualitative assay devices and methods is described. Binding of the chosen analyte simultaneously to a first 34a and a second 34b analyte-specific side member of the cleavable spacer 30 of the signal element tethers the signal-responsive moiety 41 (e.g. a gold sphere), attached to the spacer's signal responsive end 32, via the spacer's substrate-attaching end 31, to the substrate, despite subsequent cleavage at the cleavage site 33 that lies intermediate the first and second side members. The side members are attached to the spacer intermediate the respective signal responsive and substrate attaching ends.  The signal responsive moiety remains bound to the substrate after cleavage at the cleavage site only when both of the side members are bound to the chosen analyte.  Assay devices comprising the cleavable signal elements are described, as are analytic methods adapted to their use. The analytic devices of the present invention may be adapted to detection using conventional CD-ROM and DVD readers.
Patent NZ-334502-A (NZ)
Title: Shear separation method and system for process fluids
Inventor: BRANTLEY JOHN D
IPC: B01D61/14
Filed: 1997-09-05
Abstract: A shear separation system or method uses shear lift forces and permeate drag forces to separate substances having a size less than a predetermined separation size from substances having a size greater than the separation size. The balance of the drag forces and lift forces affects a predetermined separation size in that the balance of forces retards the transmembrane passage of substances larger than the separation size yet allows substances smaller than the separation size to pass through the permeable membrane. The shear separation device, method and system can be employed to separate or concentrate from a process fluid substances larger or smaller than the predetermined separation size.
Patent NZ-337222-A (NZ)
Title: Linear peristaltic pump
Inventor: PHALLEN IVER J
IPC: F04B43/00
Filed: 1998-01-16
Abstract: A liquid pumping apparatus is disclosed for pumping liquids, more specifically a linear peristaltic pump apparatus. The apparatus consists of a high durometer compressible elastomeric liquid flow tube (12), an infeed valve assembly (26), an outfeed valve assembly (38), an extensible and retractable actuator anvil (34) having a round surface which engages the flow tube (12) at all times, an opposed anvil (24.1) having a round surface in engagement with the flow tube at all times, the flow tube being held between the anvils (34, 24.1) in a slightly compressed state when the anvil (34) is retracted, and a control assembly (100) for causing the movable anvil to be sequentially extended and retracted to cause flow within the flow tube (12) from the infeed valve assembly (26) to the outfeed valve assembly (38). With this apparatus the lumen of the flow tube (12) to the sides of the anvils is not completely reduced to zero volume during displacement compression whereby gas embolisms do not erupt or explode when discharged. Two principal embodiments are disclosed, one having infeed and outfeed check valves which oclude the flow tube, and the other having check valves.
Patent NZ-337571-A (NZ)
Title: Inner sole of layers of plastic mesh fabric
Inventor: BROADMORE LES
IPC: A43B13/38
Filed: 1999-09-01
Abstract: An innersole for footwear comprising a plurality of layers; each a woven layer of plastic mesh (3). Each layer is held together by way of stitching around or adjacent to the outer edge of the plastic mesh.
Patent NZ-501417-A (NZ)
Title: Crystalline polymorphs of descarbonylethoxyloratadine (8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6] cyclohepta[1,2-b]pyridine) and methods for their use
Inventor: ECKHART CHARLES G
IPC: A61P37/00
Filed: 1998-07-01
Abstract: [ Patent 501417 Crystalline polymorphs of 8-chloro-6, 11-dihydro-11- (4-piperidylidene) -5H-benzo[5,6] cyclohepta[1,2-b]pyridine (descarbonylethoxyloratadine) represented by formula (I), pharmaceutical compositions containing such polymorphs, and methods of using these polymorphs to treat allergic reactions in mammals are disclosed.
Patent NZ-501470-A (NZ)
Title: Reinforced plasterboard
Inventor: GERLICH JOHAN THEODOOR
IPC: B28B5/02
Filed: 1998-07-16
Abstract: A reinforced plasterboard has a first external layer of paper (11), a core of a cementitious material (gypsum plaster)(15), at least one internal layer of a mesh reinforcement (7) embedded within an opposite side of the core and in contact with a further external layer of paper (2).  A continuous board manufacturing process is disclosed.
Patent NZ-501642-A (NZ)
Title: Fuel cell with compressive sheet between electrode and interconnector sheet
Inventor: HICKEY DARREN BAWDEN
IPC: H01M8/249
Filed: 1998-06-10
Abstract: A fuel cell is assembled from of a stack of a plurality of planar fuel cells (16) each including an electrolyte layer (20) having an anode layer (18) on one side and a cathode layer (22) on the other side and a plurality of interconnect members (12, 14).  Each fuel cell (16) is disposed between and in electrical contact with an adjacent pair of interconnect members (12, 14) with oxygen-containing gas passages (28) being formed between the cathode layer (22) of each fuel cell (16) and the adjacent interconnect member (14) and fuel gas passages (38, 42) being formed between the anode layer (18) of each fuel cell (16) and the adjacent interconnect member (12). A chamber (36) of greater height than the thickness of the respective fuel cell (16) is defined between the adjacent interconnect members (12, 14) in each pair within which the fuel cell (16) is received, and an electrically conductive compressible element (32, 38, 40, 42) that is disposed within the chamber (36) in electrical contact with a first side (18) of the fuel cell (16) and the adjacent interconnect member (12) urges the fuel cell (16) towards the adjacent interconnect member (14) on the second side (22) to maintain the fuel cell (16) in electrical contact with both adjacent interconnect members (12, 14). The fuel cell assembly (10) may include only a single fuel cell (16) between two interconnect members (12, 14). The compressible element (32) may be a corrugated sheet (42) of Ni or Ni alloy.
Patent NZ-502050-A (NZ)
Title: Microbial sampler and concentrator
Inventor: BRADLEY BRUCE J
IPC: B01D21/26
Filed: 1998-06-09
Abstract: A microbial sampling, filtration, and recovery device which utilizes a wash solution on meat carcasses and a vacuum source to vacuum the wash solution and suspended microbes into a collection device. The collection device includes pre-filters for removing debris, and a microbial filter. The filter is small enough to filter out bacteria, and since this size of filter seriously reduces air-flow, an alternate route for air is provided through a hydrophobic filter. Bacteria captured on the filter are back-flushed into a collection vessel where it is concentrated in a subsequent centrifuge step. The concentrated microbial sample is available for use in rapid detection methods.
Patent NZ-503715-A (NZ)
Title: Drug delivery system for use in animal body cavities
Inventor: DUIRS GRAHAM FRANCOIS
IPC: A61D7/00
Filed: 1998-10-06
Abstract: A substance delivery device 1 for delivering drugs into body cavities.    The device includes a support frame 2 capable of receiving and releasing a substance delivery pod 3 which is attached to the free end of each resilient arm 4 and 5 of the delivery device. The resilient arms 4 and 5 of the device are flexible to allow the delivery pods to enter the body cavity.
Patent NZ-505034-A (NZ)
Title: Substituted propanoic acid derivatives useful as antipicornaviral compounds
Inventor: WEBBER STEPHEN E
IPC: A61K31/4164
Filed: 1998-12-15
Abstract: A compound or a pharmaceutically acceptable prodrug, salt, active metabolite, or solvate thereof has the formula (I) and is useful for inhibiting picornaviral protease activity, wherein: M is O or S and R1 is H, F, alkyl, OH, SH or O-alkyl; G is -X-Y1-A1(D1)-B1 and G' is -X-Y2-A2(D2)-B2; R2 and R5 are independently H, alkyl, G or G' provided that the alkyl is different from G or G' and that at least one of R2 or R5 must be is G or G' and when R2 or R5 is G then X is =CH or =CF and Y1 is =CH or =CF or X and Y1 together with Q' form a three-membered ring in which Q' is -C(R10)(R11)- or -O-, X is -CH- or -CF-, and Y1 is -CH-, -CF- or -C(alkyl)- or X is -CH2-, -CF2-, -CHF-, or -S-, and Y1 is -O-, -S-, -NR12-, -C(R13)(R14)-, -C(O)-, -C(S)- or -C(CR13R14)-; A1 is C, CH, CF, S, P, Se, N, NR15, S(O), Se(O), P-OR15, or P-NR15R16; D1 is a moiety with a lone pair of electrons capable of forming a hydrogen bond and B1 is H, F, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -OR17, -SR17, -NR17R18, -NR19NR17R18, or -NR17OR18 or when R2 or R5 is G' X is =CH or =CF and Y2 is =C, =CH or =CF, or X and Y2 together with Q' form a three-membered ring in which Q' defined above, X is -CH- or -CF-, and Y2 is -CH-, -CF-, or -C(alkyl)- or X is -CH2-, -CF2-, -CHF- or -S-, and Y1 is -O-, -S-, -NR'12 -, -C(R'13)(R'14)-, -C(O)-, -C(S)--, or -C(CR'13R'14)-; A2 is the same as A1 as defined above; D2 is the same as D1 as defined above and B2 is the same as B1 as defined above or further wherein any combination of Y2, A2, B2, and D2 forms a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; R3 and R6 are independently H, F, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -C(O)R17, -OR17, -SR17, -NR17R18, -NR19NR17R18, or -NR17OR18 or, together with the carbon atom to which they are attached, form a cycloalkyl group or a heterocycloalkyl group; R4 is any suitable organic moiety, or R4 and R3 or R6, together with the atoms to which they are attached, form a heterocycloalkyl group; R7 is H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -OR17, -SR17, -NR17R18, -NR19NR17R18 or -NR17OR18 or R7, together with R3 or R6 and the atoms to which they are attached, forms a heterocycloalkyl group; R8 is H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, -NR29R30, -OR29, or -C(O)R29 or R8, together with R4 and the nitrogen atom to which they are attached, forms a heterocycloalkyl group or a heteroaryl group, or R8 and R3 or R6, together with the atoms to which they are attached, forms a heterocycloalkyl group; limited by the provisos listed in the specification including the proviso that when R7 is H, R8 is a moiety other than H and  R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R'12, R'13, R'14, R29, R30, Z and Z1 are as defined in the specification.
Patent NZ-506742-A (NZ)
Title: Synthesis of desoxyepothilones and hydroxy acid derivative intermediates
Inventor: HARRIS CHRISTINA
IPC: C07D313/00
Filed: 1999-02-24
Abstract: A method of preparing a desoxyepothilone of formula (I) and (IA) comprises: a)  treating  an epothilone of formula (II) or  (IIA)  under suitable conditions so as to deoxygenate the epothilone, and thereby to provide the desoxyepothilone or b)  treating  a protected epothilone of formula (IIB)  under suitable conditions to form the epothilone. In formulae (I), (IA), (II), (IIA) and (IIB) R,   Ro  and  R'  are  independently  H,  alkyl,  optionally substituted  by  hydroxy,  alkoxy, carboxy,  carboxaldehyde, alkyl or cyclic acetal, fluorine, NR1R2, N-hydroxy-imino, or N-alkoxy-imino; R1 and R2 are independently H, phenyl, benzyl, alkyl; R" is-CY=CX-, H, alkyl, phenyl, 2-methyl-1, 3-thiazolinyl, 2- furanyl,  3-furanyl,  4-furanyl,  2-pyridyl,  3-pyridyl,  4- pyridyl, imidazolyl, 2-methyl-1,3-oxazolinyl, 3-indolyl or 6- indolyl;   X  is  H,  alkyl,  phenyl, 2-methyl-1,  3-thiazolinyl,  2- furanyl,  3-furanyl,  4-furanyl,  2-pyridyl,  3-pyridyl,  4- pyridyl, imidazolyl, 2-methyl-1,3-oxazolinyl, 3-indolyl or 6- indolyl; Y is H or alkyl; Z is O, N (OR3) or N-NR4R5; R3, R4 and R5 are independently H or alkyl; RA    is    alkyl,   alkoxyalkyl,   optionally   substituted aryloxyalkyl,        trialkylsilyl,        aryldialkylsilyl, diarylalkylsilyl, triarylsilyl, acyl, optionally substituted aroyl or benzoyl; RB   is   hydrogen,   t-butyloxycarbonyl,   amyloxycarbonyl, (trialkylsilyl)     alkyloxycarbonyl,     (dialkylarylsilyl) alkyloxycarbonyl,  benzyl, trialkylsilyl,  dialkylarylsilyl, alkyldiarylsilyl, triarylsilyl, acyl, optionally substituted aroyl or benzoyl and n is 0 to 3.
Patent NZ-517329-A (NZ)
Title: Gas bearing and method of making a gas bearing for a free piston machine
Inventor: UNGER REUVEN Z-M
IPC: F02G1/053
Filed: 2000-08-03
Abstract: A gas bearing structure including a cylindrical core (30) and a cylindrical sleeve (50). The core (30) has a radially outwardly facing surface with longitudinal and circumferential grooves formed thereon. The sleeve (50) has a radially inwardly facing surface that sealingly abuts the outer core surface. The inwardly facing sleeve (50) surface bridges over the grooves, defining fluid, preferably gas, flow paths within each groove. The gas flow paths permit gas to flow from the workspace to radial passages formed through the sleeve sidewall, thereby forming a gas bearing.
Patent NZ-518055-A (NZ)
Title: Landing stage for offshore wind power installation with ship mooring and helicopter landing facilities, and common bridge to installation
Inventor: WOBBEN ALOYS
IPC: F03D11/04
Filed: 2000-07-15
Abstract: A  landing  stage is disclosed for an  offshore  wind- driven  power plant with a docking site 28 for ships  30,  a landing  pad 25 for a helicopter 26 and a common  bridge  32 leading from the docking  site and the landing site  to  the plant.
Patent NZ-520598-A (NZ)
Title: TRADE molecules and uses related thereto
Inventor: WOOD CLIVE
IPC: C12N5/09
Filed: 2001-02-09
Abstract: Disclosed are methods of modulating proliferation and apoptotic state of cells using agents that modulate the expression and/or activity of TRADE family polypeptides. In particular, two extracellular regions of members of the TRADE family of polypeptides are disclosed as useful in such methods. These methods and polypeptides are particularly useful where the cells are carcinoma or adenocarcinoma cells.
Patent NZ-521396-A (NZ)
Title: Fusion proteins comprising two or more Neisseria polypeptides
Inventor: ARICO MARIA BEATRICE
IPC: C12P21/02
Filed: 2001-02-28
Abstract: The heterologous expression of proteins from Neisseria using a hybrid protein of formula NH2-A-B-COOH wherein A and B are different, and wherein either comprises an amino acid sequence ÄG287 or ÄG741 and the hybrid protein.