baber/WOPTO huggingface dataset:
Patent JP-2000507688-A (JP)
IPC: A61B5/055
Filed: 1997-03-27
Abstract: A method and apparatus for accumulation of hyperpolarized 129Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.
Patent JP-H11506094-A (JP)
Title: ３（２ｈ）−ピリダジノン誘導体及びその化合物含有の製薬学的組成物
IPC: A61K31/50
Filed: 1996-05-28
Abstract: (57)【要約】
本発明は、式(１)のＲ-２-[３-([１,４]ベンゾジオキサン-２-イルメチルアミノ)-１-プロピル]-３(２Ｈ)-ピリダジノン及び式(２)のＳ-２-[３-([１,４]ベンゾジオキサン-２-イルメチルアミノ)-１-プロピル]-３(２Ｈ)-ピリダジノン及びその酸付加塩及びそれら化合物を含有する製薬学的組成物に関する。
 更に、本発明は、上記の化合物の製法に関する。式(４)及び式(５)の新規な出発原料化合物もまた本発明の範囲内に含まれる。本発明による化合物は、α 1 -及びα 2 -アドレノセプター拮抗作用及び泌尿生殖器の選択度を有する。従って、これらは、良性の前立腺肥大症の処置に有用である。
Patent JP-2001516345-A (JP)
Title: ２−アリールシクロペンタン−１，３−ジオン
IPC: C07C69/757
Filed: 1998-02-18
Abstract: (57)【要約】
式(Ｉ)の新規2-アリール-3-ヒドロキシ-Δ 2 -シクロペンテン-1-オン誘導体（式中、Ａ、Ｂ、Ｄ 1 、Ｄ 2 、Ｗ、Ｘ、ＹおよびＺは明細書中に与える意味を有する）、ならびにその製造法および除草剤および有害生物防除剤としての使用法を開示する。
Patent JP-2000509472-A (JP)
Title: 自己コイニング締結具
IPC: B23P11/00
Filed: 1997-04-25
Abstract: (57)【要約】
その一側部に圧印傷を残すことなく、少なくとも２枚の薄板金属（１１０、１１２）を共に接続するために使用することができる自己コイニング締結具（５０）である。このため、本発明の自己コイニング締結具（５０）は、接続した層（１１０、１１２）の一側部にて完全に面一の面を生じさせる。締結具（５０）は、上面（５２）と底面（５４）とを備えており、該上面（５２）は、底面（５４）よりも大径である。２つの直径の面の間にて遷移し得るように締結具（５０）の外周の周りに溝（６０）が形成されている。締結具（５０）の上面（５２）は大径であるため、締結具（５０）を取り付ける上側ダイ（１４０）にコイニングリングは不要である。この大径のヘッド部分（５２）は、接続した層（１１０、１１２）内の金属を中央溝（６０）内に押し込むため、自己コイニング式に機能する。その結果、取り付けた締結具（５０）において、圧印傷が存在せず、大径の上面（５２）は接続した金属（１１０、１１２）の上面と完全に面一となる。
Patent JP-2001515431-A (JP)
IPC: B60N2/90
Filed: 1998-02-27
Abstract: The apparatus stimulates the muscles of a seat occupant. The apparatus includes a flexible supporting element adapted to be coupled to a seat for movement relative thereto and driving means for automatically and repeatedly moving the flexible supporting element through an adjustment cycle. The adjustment cycle includes a plurality of first incremental movements in a first direction followed by a plurality of second incremental movements in a second direction. Each of the first and second incremental movements are separated by a first time interval. The method relieves muscle fatigue in a seat occupant by incrementally adjusting the curvature of the supporting element and generally includes the steps of placing a supporting element in a first position operatively engaging a muscle of the seat occupant wherein the first position defines a first degree of curvature of the supporting element. The method further includes automatically adjusting the curvature of the supporting element according to an adjustment cycle that includes maintaining the first degree of curvature for a first time period, increasing the degree of curvature a first amount after the first time period to define a second degree of curvature, maintaining the second degree of curvature for a second time period, and decreasing the degree of curvature of the supporting element a second amount after the second time period to define a third degree of curvature wherein the first time period is equal to the second time period.
Patent JP-2000510186-A (JP)
Title: コンタクトレンズへのタンパク質の堆積を阻害する組成物および方法
IPC: A61L12/14
Filed: 1997-04-30
Abstract: (57)【要約】
本発明は、親水性コンタクトレンズ上のタンパク質堆積の眼内インヒビターおよび/または眼外インヒビターとして用いられる組成物ならびに方法に関する。本発明の組成物は、親水性コンタクトレンズに選択的に結合してタンパク質性物質の結合をブロックする、適度に荷電したポリクォータニウムポリマーを含む。本発明の組成物は、コンタクトレンズ用の多目的クリーニング溶液において用いられ得、そしてタンパク質性物質を除去するための特別な酵素クリーナーなどの必要性をなくすことができる。
Patent JP-2000511416-A (JP)
IPC: C12N1/21
Filed: 1997-05-23
Abstract: According to the present invention there is provided a specific binding member which is specific for and binds directly to the ED-B oncofoetal domain of fibronectin (FN). The invention also provides materials and methods for the production of such binding members.
Patent JP-2000501870-A (JP)
Title: グラフィック・タブレット
IPC: G06F3/044
Filed: 1997-04-30
Abstract: (57)【要約】
グラフィック・タブレット（１００）は、多数の平行電極群（１０６〜１１０）を備え、その電極群には、電極群に対するペン（１０４）の位置を判定するために一連のパターン（６０２〜６０８）が提示されている。その提示の結果として、一連の符号要素（６１４）が電極上に形成され、その符号要素をペンで拾い上げて関連した電極を表わすことができる。パターンを適切に選定すれば、短い列のパターンで足りるので、位置の判定には時間がかからない。
Patent JP-2002516051-A (JP)
Title: 相関器の方法および装置
IPC: H04W88/02
Filed: 1998-04-07
Abstract: (57)【要約】
バーストモードの符号分割多元接続（ＣＤＭＡ）直接シーケンス・スペクトラム拡散（ＤＳＳＳ）信号を受信して処理するための方法および装置を提供する。この装置および方法には、複数の復調器が所定の列挙順序で設けられている。各復調器は、自由に信号を処理できることを意味する「作動可能」かまたは現在信号を処理していることを意味する「使用中」のいずれかになっている。作動可能復調器はそれぞれ、入力ＩＦ信号を受信し、ＩＦ信号内のプリアンブルを検出しようと試みる。プリアンブルを検出すると、各作動可能復調器はアービトレータに要求信号を送信する。受信した要求信号に応答して、アービトレータは列挙順序において第１の作動可能復調器に許可信号を送信する。この許可信号は、列挙順序において第１の作動可能復調器より上位の各使用中復調器を通過する。次に第１の作動可能復調器は、信号の処理を開始し、作動可能復調器の組から使用中復調器の組に移動する。残りの作動可能復調器は入力信号の処理を続行する。使用中復調器が信号の処理を完了すると、その復調器は作動可能復調器の組に戻る。
Patent JP-2001524150-A (JP)
IPC: C09D163/00
Filed: 1998-05-01
Abstract: A process for producing an aqueous coating composition comprising an aqueous dispersion of internally cross-linked polymer microgel particles in which the microgel particles are produced by emulsion polymerisation of ethylenically unsaturated monomers including carboxyl functional monomer in an aqueous medium so as to form an aqueous dispersion of carboxyl functional addition polymer followed by reacting this polymer dispersion with a diepoxide resin having an epoxide equivalent weight between 100 and 5000 to form the cross-linked polymer microgel particles.
Patent JP-2002502237-A (JP)
Title: 核酸分子の生成および精製のための方法
IPC: C12N15/10
Filed: 1998-05-12
Abstract: (57)【要約】
本発明は、核酸分子の生成および単離のための方法に関する。特に、本発明は、mRNA分子の単離、ならびに１本鎖および２本鎖であり得る核酸分子（例えば、cDNA分子またはライブラリー）の生成および単離に関する。さらに、本発明は、分子の集団を含み得るサンプルからの、目的の特定の核酸分子の選択および単離に関する。詳細には、本発明は、アフィニティー標識されたプライマー−アダプター分子に関し、これはこのような核酸分子の改善された単離および生成を可能にし、産物回収および単離のスピードの両方を増加する。
Patent NZ-186250-A (NZ)
Title: Disc mower with endless belt swath former
Inventor: OOSTERLING P A
IPC: A01D57/30
Filed: 1978-01-18
Abstract: In order to prevent the adhesion of crop to a swath board of a mowing device, the or each swath former comprises an endless member passed around a foremost and a hindmost reversing element, viewed in the direction of movement, the crop advancing run of said member being at an acute angle to the carrier.
Patent NZ-200408-A (NZ)
Title: Non-electric blasting assembly and connector
Inventor: YUNAN M E
IPC: F42B3/10
Filed: 1982-04-26
Abstract: A percussion-actuated instantaneous or delay detonator transmits a detonation from a first length of low-energy detonating cord (LEDC) transversely positioned adjacent the detonator's percussion-responsive end to a U-shaped segment of a second length of LEDC held with its apex against the base-charge end of the detonator and the arms of the U extending away from the detonator. A directional connector for connecting a U-shaped segment of detonating cord adjacent each end of the detonator has identifiable donor- and receiver-cord-housing sections, e.g., the receiver-cord-housing section has the shape of the head, and the donor-cord-housing section the shape of the butt, of an arrow. A connector adapted to hold receiver LEDC and high-energy detonating cord (HEDC) segments is internally configured to receive nested U-shaped segments of LEDC and HEDC only when the LEDC is adjacent the base-charge end of the detonator.
Patent NZ-206375-A (NZ)
Title: Reducing malic acid to lactic acid in wine
Inventor: KING S W
IPC: C12H1/00
Filed: 1983-11-23
Abstract: An improved method for malolactic fermentation to reduce the acidity of wine is described. The wine or must is inoculated with a specially activated bacterial culture which accomplishes the fermentation.
Patent NZ-218452-A (NZ)
Title: Preparation of cefodizime
Inventor: JAENICKE O
IPC: C07D501/36
Filed: 1986-12-01
Abstract: A process for the preparation of cefodizime of the formula   <IMAGE> +TR   <IMAGE>  wherein (a) a compound of the formula II (ATS) <IMAGE>   wherein R1 represents hydrogen or an aminoprotective group and A represents a hydrogen atom or one equivalent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first reacted with a compound of the formula III R-SO2Hal  wherein R represents an optionally substituted alkyl, aryl or aralkyl radical and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base, (b) a compound of the formula I (TACS)   <IMAGE>    in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appropriate, in the presence of a base, and (c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R1 present in the end product of the formula I is eliminated.
Patent NZ-240247-A (NZ)
Title: Purified monoclonal antibodies against cd 52 lymphocyte antigen
Inventor: RAMAGE PAUL IAN NICHOLAS
IPC: A61K/
Filed: 1991-10-16
Abstract: Following are described. (A) purified prepn. of an anti-CDw52 antibody which exhibits on size exclusion chromatography a single peak under non-reducing conditions and 2 major peaks under reducing conditions; esp. the prepn. exhibits on conventional SDS polyacrylamide gel electrophoresis, one main band using a non-reduced sample and two main bands using a reduced sample; (B) purified prepn. of an anti-CDw52 antibody having a specific activity greater than 0.8 KU/mg; (C) purified prepn. of an anti-CDw52 antibody, free from host cell contaminants and/or aggregates; (D) purifying an anti-CDw52 antibody comprising (a) applying an aqs. soln. of the antibody to a Protein A column so as to absorb the antibody and eluting the antibody with an acid soln., (b) applying the acidic eluate to an ion-exchange column of charged particles to absorb the antibody and then eluting the antibody with an aqs. soln. of counter-charged ions and (c) applying the aqs. eluate to a size exclusion column of porous particles to retain non-antibody mols. in the porous particles and to obtain the desired antibody in selected fractions produced from the column. Pref. the Protein A column is Protein A Sepharose and the antibody is eluted with citric acid.
Patent NZ-243890-A (NZ)
Title: An osmotic device for the controlled delivery of a beneficial agent to an oral cavity of an animal over a period of time
Inventor: BARCLAY BRIAN L
IPC: A61K9/22
Filed: 1990-07-11
Abstract: An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.
Patent NZ-244980-A (NZ)
Title: Injection device operated by a deformable plastics ampoule
Inventor: CARTER STEPHEN JOHN
IPC: A61M5/28
Filed: 1992-11-02
Abstract: The present invention provides an injection device (1) adapted to engage a deformable plastic ampoule (2) having a reservoir (3) and a neck portion (4), said device comprising: a body (5) having a continuous fluid conduit (6) therethrough, the fluid conduit comprising at one end a male frusto-conical extending member (8) forming a sealing surface with a corresponding parallel walled or frusto-conical female recess (10) on the neck portion (4) of said ampoule (2) when the ampoule and the device are cooperatively engaged. This device is simple to use and is suitable for self-injection by patients.
Patent NZ-260693-A (NZ)
Title: Treating hot process gases in fluidised bed reactor
Inventor: HYPPANEN TIMO
IPC: B01D45/02
Filed: 1994-06-07
Abstract: A method and apparatus for treating hot process gases produced in high temperature processes in a circulating fluidized bed reactor. The reactor (10) comprises a mixing chamber (12), a particle separator (16) and a return duct (18) for returning the circulating mass from the particle separator to the mixing chamber. The return opening (24) of the return duct is so arranged that the flow of solids entering the mixing chamber via the opening is directed substantially downwardly. The inlet (22) for hot process gas is so arranged as to allow the hot process gas to flow into the mixing chamber as a substantially upwardly directed solids flow so that the solids flow comes into contact with the gas flow. <IMAGE>
Patent NZ-284277-A (NZ)
Title: Optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1 -piperidinebutanol derivatives
Inventor: NAKAMURA MITSUO
IPC: C07B57/00
Filed: 1995-04-10
Abstract: A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1 -piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1 -piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.
Patent NZ-284974-A (NZ)
Title: Small arms laser transmitter
Inventor: PARIKH HIMNASHU N
IPC: F41G3/26
Filed: 1995-04-28
Abstract: A laser small arms transmitter (SAT) which may be affixed to the stock of a rifle such as an M16 used by a soldier in training with a multiple integrated laser engagement system (MILES). The transmitter includes a housing assembly having a forward end with a window through which the beam of a laser diode is emitted. A pair of optical wedges are positioned inside the housing assembly between the laser diode and the window. The optical wedges are supported for independent rotation about a common optical axis for steering the laser beam. An alignment head may be physically mated to the rearward end of the housing assembly for driving a pair of shafts to rotate the optical wedges in the alignment of the transmitter so that a soldier can accurately hit a target once he or she has located the target in the conventional sights of the rifle. The laser transmitter may also include a sensor for detecting the firing of a blank cartridge, a fire LED mounted inside the housing for producing an optical signal to indicate to the alignment head that the laser diode has been energized, and an inductive switch connected to a power circuit and actuable by an induction coil in the alignment head to energize the laser diode.
Patent NZ-288901-A (NZ)
Title: Purified polyporus laccase, used for polymerising a lignin or lignosulphate substrate, in situ depolymerisation in kraft pulp, oxidising dyes and dying hair
Inventor: YAVER DEBBIE SUE
IPC: C12N15/09
Filed: 1995-06-15
Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Polyporus laccase, and the laccase proteins encoded thereby.
Patent NZ-335206-A (NZ)
Title: Rigid polyurethane foams
Inventor: SIEKER THOMAS HEINRICH
IPC: C08G18/20
Filed: 1997-10-10
Abstract: Process for making rigid polyurethane or urethane-modified polyisocyanurate foams comprising the step of reacting an organic polyisocyanate composition with an isocyanate-reactive composition comprising a polyester polyol in the presence of an amine catalyst characterized in that the pKa of the conjugated ammonium salt of said amine is less than 12.
Patent NZ-336586-A (NZ)
Title: Lead-free tin alloy with improved mechanical and thermal properties for solder joints comprising indium, aluminium, magnesium and zinc
Inventor: OUD MARTINUS ADRIANUS
IPC: B23K35/26
Filed: 1998-01-28
Abstract: A lead-free tin alloy for solder joints comprising up to 0.25 % by weight of indium and a grain refiner which is an alloy consisting of, by weight, 2.5 to 10 % aluminium, 1 to 5 % magnesium and balance zinc. The alloys have improved mechanical properties, such as creep strength, and an improved thermal fatigue strength.
Patent NZ-337049-A (NZ)
Title: Toothbrush
Inventor: KRAMER HANS
IPC: A46B5/00
Filed: 1998-02-17
Abstract: A toothbrush comprises a handle (2) and a head (3) having a base end (4) facing the handle and a tip end (5) remote from the base end. A neck region (6) is between the base end of the head and the handle with the head adjoining the neck region at the base end of the head. The head, neck and handle are disposed along a longitudinal toothbrush direction (A) and the head has bristles (8) extending from a bristle face of the head with the head comprises a maximum of two bristle bearing segments. The first bristle bearing segment is a substantially rigid base segment (10) adjoining the toothbrush neck and extending from the base end of the head to a first resilient flexible link (11) situated between the base end and the tip end. The second bristle bearing segment is a substantially rigid tip segment (12) extending from the tip end of the head to the link. The tip region is flexibly and resiliently linked at the link to the base region and between the base end of the head and the neck there is a second resilient flexible link (15) comprising a composite region of plastics material and an elastomeric material.
Patent NZ-500843-A (NZ)
Title: A method of DNA recombination which is selectable to select for cells containing a product and against cells only harbouring the insert donor
Inventor: HARTLEY JAMES L
IPC: C12N9/00
Filed: 1996-06-07
Abstract: An in vivo method of producing a Product nucleic acid molecule comprising: (a) introducing into a host cell (i) an Insert Donor nucleic acid molecule, comprising a desired nucleic acid segment flanked by a first recombination site and a second recombination site, wherein the first and second recombination sites do not recombine with each other; and (ii)  a Vector Donor nucleic acid molecule, comprising a third recombination site and a fourth recombination site, wherein the third and fourth recombination sites do not recombine with each other; (b) causing the Insert Donor and Vector Donor nucleic acid molecules to recombine within the host cell, thereby producing a Product nucleic acid molecule; and (c) isolating a host cell comprising the Product nucleic acid molecule but not the Insert Donor nor the Vector Donor nucleic acid molecules. The method enables efficient and specific recombination of DNA segments using recombination proteins. The DNAs, vectors and methods are useful for a variety of DNA exchanges, such as subcloning of DNA in vivo.
Patent NZ-502557-A (NZ)
Title: Nucleic acid sequence analysis
Inventor: DENSHAM DANIEL HENRY
IPC: C12Q1/68
Filed: 1998-07-24
Abstract: A method for sequencing a polynucleotide, comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilised on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting an effect consequent on the incorporation of a specific nucleotide complementary to the target polynucleotide, wherein said effect is detected by measuring radiation.
Patent NZ-506475-A (NZ)
Title: Treatment of stressed ruminants with 1,2-dihydroxyquinoline compounds, in particular 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
Inventor: OWENS FREDRIC N
IPC: A23K1/18
Filed: 1999-03-22
Abstract: The collective health, feed efficiency, weight gain and faecal odours of stressed ruminants can be affected by feeding them a diet of feed comprising a substituted 1,2-dihydroquinoline compound; a 6-ethoxy-1,2-dihydro-2,2,4-trimrthylquinoline in particular.  The feed should comprise between 50 and 1000 ppm by weight 6-ethoxy-1,2-dihydro-2,2,4-trimrthylquinoline.
Patent NZ-507987-A (NZ)
Title: Assay for methylation in the GST-Pi gene
Inventor: CLARK SUSAN JOY
IPC: C12Q1/68
Filed: 1999-04-23
Abstract: A diagnostic or prognostic assay is disclosed for a disease or condition characterised by abnormal methylation of cytosine at a site or sites within the glutathione-S- transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g. prostate cancer and liver cancer). The assay comprises: (i) isolating DNA from said subject, and (ii) determining (e.g. by selective PCR amplification) the presence of abnormal methylation of cytosine at a site or sites within the GST-Pi gene and/or its regulatory flanking sequences.
Patent NZ-511628-A (NZ)
Title: Highly bi-axially oriented, heat-shrinkable, thermoplastic, multi-layer film and process for the manufacture thereof
Inventor: FORLONI ROBERTO
IPC: B29C55/16
Filed: 1999-12-13
Abstract: A process for manufacturing a highly bi-axially oriented, heat-shrinkable, thermoplastic, multi-layer film comprising a core layer (A) comprising an ethylene-vinyl alcohol copolymer (EVOH), a first outer layer (B) comprising an ethylene homo-or co-polymer and a second outer layer (C), which may be equal to or different from the first outer layer (B), comprising an ethylene homo-or co-polymer, which process comprises extrusion of the film resins through a flat die and bi-axial orientation of the obtained cast sheet simultaneously in two perpendicular directions at an orientation ratio in the longitudinal direction higher than 4:1 and an orientation ratio in the cross-wise direction higher than 4:1.  Also included is the film produced by the process.
Patent NZ-514710-A (NZ)
Title: Methods of identifying compounds which affect binding between two key regulatory regions of voltage-gated sodium and potassium ion channels
Inventor: YOUNG KATHLEEN H
IPC: G01N33/566
Filed: 2000-04-20
Abstract: Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an alpha subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders and diseases that are cardiac, metabolic, autoimmune and tumour-driven. Patent Addition Number 523190