Patent GB-804985-A (GB)
Title: Stabilized vitamin a compositions
IPC: A61K31/59
Filed: 1956-01-23
Abstract: The invention comprises a Vitamin A composition having incorporated therein as stabilizer, 2,6-di-tertiary butyl-4-methyl phenol in combination with tocopherol, and a process for the production thereof which consists in intimately admixing with a Vitamin A active material, 2,6 - di - tertiary butyl - 4 - methyl phenol in combination with tocopherol.  The combination of tocopherol and 2,6-di-tertiary butyl-4-methyl phenol in relative proportions of 1 to 5 parts of tocopherol to each part of 2,6 - di - tertiary butyl - 4 - methyl phenol, the tocopherol being present in addition to any tocopherol naturally present in other constituents of the composition, also forms part of the invention.  As Vitamin A-active materials there may be used Vitamin A alcohol, Vitamin A aldehyde, Vitamin A acetate, Vitamin A palmitate, axerophthen and Vitamin A ethers.  The stabilizer may be used in solutions of Vitamin A-active materials in corn oil, cottonseed oil, soybean oil, lard oil, beef tallow oil and sardine oil.  The 2,6-ditertiary butyl-4-methyl phenol can be employed in amounts ranging from 1.0 mg. to 50 mg. per 1,000,000 U.S.P. units of Vitamin A with amounts from 2.0 mg. to 30 mg. per 1,000,000 U.S.P. units of Vitamin A being preferred. The tocopherol can be employed in amounts ranging from 5 mg. to 150 mg. per 1,000,000 U.S.P. units of Vitamin A, with amounts from 10 mg. to 50 mg. per 1,000,000 units of Vitamin A being preferably employed. The proportions of 2,6-di-tertiary butyl-4-methyl phenol to tocopherol may be varied but is usually 1 : 5.ALSO:Products suitable for fortifying animal feeds comprise beadlets or pellets containing vitamin A material, e.g., vitamin A alcohol, vitamin A aldehyde, vitamin A acetate, vitamin A palmitate, axerophthene or a vitamin A ether, together with mineral wax, a solid fatty material, a gum or a synthetic resin, or comprise such vitamin A material adsorbed on a vegetable material such as soy grits, the product being stabilized against loss of vitamin A activity by the incorporation of 2,6-di-tertiarybutyl-4-methyl phenol in combination with tocopherol.ALSO:The invention comprises a Vitamin A composition having p  incorporated therein as stabilizer 2,6 - di - tertiary butyl - 4 - methyl phenol in combination with tocopherol and a process for the production thereof which consists in intimately admixing with a Vitamin A active material 2,6-di-tertiary butyl-4-methyl phenol in combination with tocopherol.  The combination of tocopherol and 2,6-di-tertiary butyl-4-methyl phenol in relative proportions of 1 to 5 parts of tocopherol to each part of 2,6-di-tertiary butyl-4-methyl phenol, the tocopherol being present in addition to any tocopherol naturally present in other constituents of the composition, also forms part of the invention.  As Vitamin A active materials there may be used Vitamin A alcohol, Vitamin A aldehyde, Vitamin A acetate, Vitamin A palmitate, axerophthene and Vitamin A ethers.  The stabilizer may be used in solutions of Vitamin A active materials in corn oil, cottonseed oil, soybean oil, lard oil, beef tallow oil and sardine oil.  The 2,6-di-tertiary butyl-4-methyl phenol can be employed in amounts ranging from 1.0 mg. to 50 mg. per 1,000,000 U.S.P. units of Vitamin A with amounts from 2.0 mg. to 30 mg. per 1,000,000 U.S.P. units of Vitamin A being preferred.  The tocopherol can be employed in amounts ranging from 5 mg. to 150 mg. per 1,000,000 U.S.P. units of Vitamin A, with amounts from 10 mg. to 50 mg. per 1,000,000 units of Vitamin A being preferably employed.  The proportion of 2,6-di-tertiary butyl-4-methyl phenol to tocopherol may be varied, but is usually 1 : 5.