Patent SG-11201805965W-A (SG)
Title: Core-shell plasmonic nanogapped nanostructured material
Inventor: DUAN HONGWEI
IPC: G01N21/65
Filed: 2017-03-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111001111111010111011111101111011111 International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/164822 Al 28 September 2017 (28.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every B82B 1/00 (2006.01) A61K 41/00 (2006.01) kind of national protection available): AE, AG, AL, AM, B82B 3/00 (2006.01) B82Y 40/00 (2011.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, GO1N 21/65 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/SG2017/050151 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 24 March 2017 (24.03.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 10201602345W 24 March 2016 (24.03.2016) SG kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: NANYANG TECHNOLOGICAL UNIVER- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, SITY [SG/SG]; 50 Nanyang Avenue, Singapore 639798 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (SG). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: DUAN, Hongwei; c/o Nanyang Technological LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, University, 50 Nanyang Avenue, Singapore 639798 (SG). SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, _ ZHOU, Jiajing; c/o Nanyang Technological University, 50 GW, KM, ML, MR, NE, SN, TD, TG). — Nanyang Avenue, Singapore 639798 (SG). Published: _ = (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; — with international search report (Art. 21(3)) _ = P.O Box 1088, Rochor Post Office, Rochor Road, Singa- - pore 911833 (SG). = = MATERIAL (54) Title: CORE-SHELL PLASMONIC NANOGAPPED NANOSTRUCTURED = _ FIG. 1 = _ Melmilzwdm = r) _ Polythapamin Or coating = = X:, Walpaparticle $ 0 ,,S\".. - Aki Poly - dopamine = f . = Polydoparnire Casting = . = .. k` ,, Metallization , ,.„ „. .. Il ei ei GP (57) : A core-shell plasmonic nanogapped nanostructured material is provided. The core-shell nanogapped nanostructured 7r material has a core and at least one shell surrounding the core, wherein the at least one shell comprises a first layer comprising a 1-1 polymer having a catechol group, wherein the first layer defines the nanogap in the core-shell plasmonic nanostructured material, ---- and a second layer comprises a metal disposed on the first layer. A method of preparing the core-shell plasmonic nanogap nanostruc - IN tunedmaterial, and use of the core-shell plasmonic nanogap nanostructured material are also provided. As an embodiment, a polydo - pamine covalently bonded to a Raman probe or a fluorescent probe is used to prepare the first layer of the shell in said core-shell N plasmonic nanogap nanostructured material, thereafter a gold shell is deposited onto the polydopamine to form a second layer of the en. ) shell. In present invention, it is demonstrated that the method is highly versatile and can be used for different core materials, includ- ing magnetic Fe 3 0 4 nanoparticles and metal-organic frameworks (MOF) nanoparticles. The potential application of said core-shell plasmonic nanogapped nanostructured in sensing and theranostics is also demonstrated.