baber/WOPTO huggingface dataset:
Patent CA-3056819-A1 (CA)
Title: Methods and compositions for stimulating immune response
Inventor: BIHI MAHJOUB
IPC: A61K39/00
Filed: 2018-03-21
Abstract: The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
Patent CA-3057460-A1 (CA)
Inventor: HALL DAVID S
IPC: G01S7/481
Filed: 2018-03-20
Abstract: Methods and systems for performing three dimensional LIDAR measurements with multiple illumination beams scanned over a three dimensional environment by one or more optical phase modulation devices are described herein. In one aspect, illumination light from each LIDAR measurement channel is emitted to the surrounding environment in a different direction by an optical phase modulation device. The optical phase modulation device also directs each amount of return measurement light onto a corresponding photodetector. The illumination pulse output of each LIDAR measurement channel is synchronized with commanded changes of state of each corresponding optical phase modulation device. In some embodiments, each optical phase modulation device is associated with a single LIDAR measurement channel. In some embodiments, multiple LIDAR measurement channels are associated with a single modulation device. In some embodiments, a one dimensional optical phase modulation device is employed. In other embodiments, a two dimensional optical phase modulation device is employed.
Patent CA-3058764-A1 (CA)
Title: Hydrodynamic vortex aspiration catheter
Inventor: SAVASTANO LUIS EMILIO
IPC: A61B17/22
Filed: 2018-04-10
Abstract: An aspiration catheter system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defming a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen. In some embodiments, the guidewire member and the flexible shaft are collectively sufficient to navigate the vascular lumen and steer translational movement of the tubular catheter member there along.
Patent CA-3063440-A1 (CA)
Title: Covalent inhibitors of kras
Inventor: LI LIANSHENG
IPC: C07D417/14
Filed: 2018-05-24
Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5, L1, L2, L3, E, m1, m2 and * are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
Patent CA-3071782-A1 (CA)
Inventor: WALDRAFF CHRISTIAN
IPC: C07D307/46
Filed: 2018-08-02
Abstract: The invention relates to 3-acyl-benzamides of formula (I) as herbicides. In formula (I) X, Y, Z and Rx represent radicals such as alkyl, cycloalkyl and halogen.
Patent CA-3073214-A1 (CA)
Inventor: AGARWAL PAVAN
IPC: G06Q50/00
Filed: 2018-09-14
Abstract: Various embodiments of the present invention provide a system and method for providing a digital status indicator on a map. According to one embodiment, a system is provided which performs the operations of: parsing through social media data of a social media user extracted from a social media platform; creating a status indicator comprising one or more categorical labels to filter the social media data into select categories of interest; correlating the status indicator with location information; outputting the status indicator with location information on a map interface; and presenting through a graphical user interface the status indicator with the location information.
Patent CA-3076557-A1 (CA)
Title: Crystalline form of alkynyl pyridine prolyl hydroxylase inhibitor and method for preparing same
Inventor: ZHAI LIJUAN
IPC: C07D213/81
Filed: 2018-10-24
Abstract: The present invention relates to a crystalline form of alkynyl pyridine prolyl hydroxylase inhibitor and a method for preparing same. Specifically, the present invention relates to the new crystalline form of alkynyl pyridine prolyl hydroxylase inhibitor as represented by formula (I). The new crystalline form of the present invention has good stability and may be better used for clinical treatment.
Patent CA-3076867-A1 (CA)
Title: Cysteine engineered antigen-binding molecules
Inventor: WOZNIAK-KNOPP GORDANA
IPC: C07K16/28
Filed: 2018-10-03
Abstract: A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.
Patent CA-3081768-A1 (CA)
Inventor: DAZZI FRANCESCO
IPC: G01N33/94
Filed: 2018-11-06
Abstract: A method is described for using live mesenchymal stromal cells (MSCs) in a way which allows for identification of patients likely to respond to immunosuppressive treatment using MSCs. The method involves contacting a sample from said patient with live MSCs in vitro, and determining whether the sample is able to induce at least some apoptosis to occur in live MSCs in vitro, or detection of elevated levels of prostaglandin E2 (PGE2). The ability of the sample to induce said apoptosis and/or elevated levels of PGE2 is indicative of responsiveness of said patient to said immunosuppressive treatment and/or indicative of fitness to recover. Also provided are apoptotic MSCs for use in the treatment of immune- mediated disease or conditions, such as allo-immune or autoimmune disease, or for the prevention or treatment of rejection of a transplanted organ; or in regenerative medicine to stimulate tissue repair. Methods for preparing pharmaceutical compositions comprising the apoptotic MSCs are also described and claimed.
Patent CA-3082384-A1 (CA)
Inventor: SCHAEPERS YVONNE
IPC: C04B40/06
Filed: 2018-11-13
Abstract: The invention relates to a binder composition which comprises cement, optionally calcium sulphate, at least one zinc salt and at least one alkyl amine, and a dry mortar mixture which contains said binder composition. The invention also relates to the use of a composition consisting of a zinc salt and an alkyl amine in order to achieve higher early strengths in a binder composition.
Patent CA-3084480-A1 (CA)
Title: System and methods directed to side-channel power resistance for encryption algorithms using dynamic partial reconfiguration
Inventor: PLUSQUELLIC JAMES
IPC: H04L9/28
Filed: 2018-10-30
Abstract: A side-channel attack countermeasure that leverages implementation diversity and dynamic partial reconfiguration as mechanisms to reduce correlation in the power traces measured during a differential power analysis (DPA) attack. The technique changes the underlying hardware implementation of any encryption algorithm using dynamic partial reconfiguration (DPR) to resist side-channel-based attacks.
Patent CA-3086462-A1 (CA)
Inventor: TOMIO Akiko
IPC: C22F1/00
Filed: 2019-01-17
Abstract: L'invention concerne un alliage Cr-Ni qui présente une limite d'élasticité élevée et une haute résistance à la corrosion généralisée par l'acide sulfurique à la température élevée de 250 °C. Cet alliage Cr-Ni a une composition chimique qui contient, en % en masse, de 0,01 % à 0,50 % de Si, de 0,01 % à 1,00 % de Mn, de 21,0 % à 27,0 % de Cr, 40,0 % ou plus mais moins de 50,0 % de Ni, 4,5 % ou plus mais moins de 9,0 % de Mo, de 2,0 % à 6,0 % de W, plus de 2,0 % mais 6,0 % ou moins de Cu, de 0,01 % à 2,00 % de Co, de 0,001 % à 0,010 % au total d'un ou de deux éléments choisis dans le groupe constitué de Ca et Mg, de 0,005 % à 0,200 % d'Al sol. et de 0,01 % à 0,20 % de N, le reste étant constitué de fer et d'impuretés. La densité des dislocations dans cet alliage Cr-Ni satisfait à la formule (1). (1) : 8,00 × 1014 = ? = 2,50 × 1015 + 1,40 × 1014 × [Cu + Co]
Patent CA-3086481-A1 (CA)
Title: Lampe bistable
Inventor: BOSNECKER ROBERT
IPC: H04M1/22
Filed: 2018-12-13
Abstract: L'invention a pour objet de réaliser un dispositif d'éclairage destiné à être fixé à des objets de différentes dimensions, notamment des appareils mobiles. L'invention réalise à cet effet un dispositif d'éclairage comprenant un élément lumineux (1) et un élément de maintien (2). L'élément lumineux (1) est fixé à une première portion d'extrémité d'un élément bistable (3, 4) et l'élément de maintien (2) à une deuxième portion d'extrémité, opposée à la première, de l'élément bistable (3, 4). Dans un premier état stable, l'élément bistable (3, 4) est déroulé de sorte que l'élément lumineux (1) est espacé au maximum de l'élément de maintien (2). Dans un deuxième état stable, l'élément bistable (3, 4) est enroulé. Le dispositif d'éclairage peut être serré contre l'appareil mobile par la force de ressort de l'élément bistable.
Patent CA-3093396-A1 (CA)
Inventor: REN DA
IPC: G01N30/06
Filed: 2019-03-13
Abstract: The disclosed methods are directed to preparing polypeptides for multi]attribute analysis. The polypeptides are optionally denatured, reduced, and/or alkylated before being subjected to a first digestion. Following the first digestion the large and small fragments resulting from the digestion are separated from each other. A second digestion is then performed on the larger of the fragments. All of the fragments from the two digestions are then analyzed chromatographically, electrophoretically, or spectrometrically, or a combination of these methods. The methods are especially useful for the preparation of therapeutic polypeptides for analysis, especially those that are not easily cleaved.
Patent CA-3093923-A1 (CA)
Inventor: BRIGHT CORINNE
IPC: A61K9/10
Filed: 2019-03-15
Abstract: Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.
Patent CA-3093969-A1 (CA)
Inventor: COREY DANIEL MARK
IPC: C12N5/0783
Filed: 2019-03-27
Abstract: The present disclosure relates to tandem expression cassettes encoding chimeric engulfment receptor molecules and chimeric antigen receptors/or T cell receptor binding proteins, host cells modified to include the tandem expression cassettes, and methods of making and using such receptor molecules and modified cells.
Patent CA-3094973-A1 (CA)
Title: Sealing material
Inventor: SHAW STUART JOHN
IPC: F16J15/10
Filed: 2019-03-29
Abstract: The present invention relates to composite sealing materials for a gasket. The gaskets are useful in solid oxide fuel/electrolyser cells (SOFC and SOEC).The fuel cell gaskets contain sealing material based upon chemically exfoliated vermiculite that has improved corrosion resistance. The sealing material comprises chemically exfoliated vermiculite; filler; and insoluble carbonate.
Patent CA-3095915-A1 (CA)
Inventor: LOMBARD PIERRE
IPC: E04F21/18
Filed: 2019-04-03
Abstract: The invention relates to an automated device (1) designed to move bearing against a construction panel (2), the automated device (1) comprising a frame (14) carrying a tool (13) designed to perform at least one mechanical operation on the construction panel (2), said automated device (1) comprising at least one suction body (24) designed to hold the automated device (1) against the construction panel (2), and at least one means (19) for initiating the movement of the automated device (1) along the construction panel (2). According to the invention, the automated device (1) comprises at least one control unit (34) designed to control at least the means (19) for initiating the movement of the automated device (1) according to at least one item of data relating to the position of a support (8) of the construction panel (2).
Patent CA-3096351-A1 (CA)
Title: Evaluation de service de reseau sans fil
Inventor: KNEBL MATTHEW
IPC: H04W4/02
Filed: 2019-04-11
Abstract: L'invention concerne des procédés de création d'un niveau de confiance intérieur consistant à : recevoir un emplacement et une valeur de précision d'emplacement à partir d'un dispositif ou pour celui-ci, la valeur de précision d'emplacement étant égale à un cercle de précision d'emplacement ; comparer l'emplacement et le cercle de précision d'emplacement à une carte d'immeubles et d'emplacements extérieurs connus ; et définir un niveau de confiance intérieur sur la base du pourcentage de chevauchement du rayon de précision sur un bâtiment de ladite carte ; et des procédés consistant à définir une priorité d'optimisation parmi un ensemble de points de données collectés pour une connectivité de réseau.
Patent CA-3097467-A1 (CA)
Title: X-ray fluorescence analyzer with a plurality of measurement channels, and a method for performing x-ray fluorescence analysis
Inventor: KOSKINEN TOMMI
IPC: G01N23/223
Filed: 2018-04-20
Abstract: An X-ray fluorescence analyzer comprises an X-ray tube (402) for emitting incident X-rays (206) in the direction of a first optical axis (204). A slurry handling unit (201) is configured to maintain a constant distance between a sample (202) of slurry and said X-ray tube. A first crystal diffractor (601, 1501) is located in a first direction from said slurry handling unit (201). It comprises a first crystal (603, 1502) and a first radiation detector (602, 1505) configured to detect fluorescent X-rays diffracted by said first crystal (603, 1502) at a first energy resolution. A second crystal diffractor (1511) is located in a second direction from said slurry handling unit (201). It comprises a second crystal (1512) and a second radiation detector (1515) configured to detect fluorescent X-rays diffracted by said second crystal (1512) at a second energy resolution. Said first crystal (603, 1502) is a pyrolytic graphite crystal, said second crystal (1512) is of a material other than pyrolytic graphite, and said first and second crystal diffractors are configured to direct to their respective radiation detectors characteristic fluorescent radiation of a same element.
Patent CA-3097586-A1 (CA)
Inventor: MITTAL NARINDER
IPC: H04L1/16
Filed: 2019-04-03
Abstract: A system can include a server and a device having a power source with a limited life span. The server receives data from the device and identifies a gap in the data from the device that indicates that at least a portion of the data from the device is missing. The server uses a gap reconciliation profile associated with the device to control the server to collect the missing data from the device. The server can generate a signal to request the missing data from the device based on the gap reconciliation profile and transmit the signal to the device to collect the missing data based on the gap reconciliation profile. A parameter of the gap reconciliation profile can be used to control generating or transmitting of the signal, which can preserve the limited life span of the power source of the device.
Patent CA-3098072-A1 (CA)
Title: Packaging system and method of using same
Inventor: LAFLAMME KARINE
IPC: B65B11/00
Filed: 2020-11-03
Abstract: A reusable packaging system for a gift, comprising: a decorative wrapping for wrapping around the gift so that the gift is concealed thereby, the decorative wrapping defining a plurality of mounting apertures; and a mount securable to the gift independently from the decorative wrapping, the mount being provided with a wrapping attachment insertable in each of the mounting apertures. The decorative wrapping is movable between attached and detached configurations. In the detached configuration, the decorative wrapping is detached from the mount. In the attached configuration, with the mount secured to the gift, the decorative wrapping is attached to the mount and encloses the gift, the decorative wrapping being secured to the wrapping attachment with the wrapping attachment inserted through at least some of the mounting apertures.
Patent CA-3099271-A1 (CA)
Inventor: Tyler Jeffery
IPC: H01F7/16
Filed: 2019-05-07
Abstract: Presented are a single coil apparatus and a method of forming. An exemplary apparatus includes solenoid assembly. The solenoid assembly includes a core tube extending along a longitudinal axis. The solenoid assembly further includes a first magnet and a second magnet located outside the core tube, the first magnet spaced along the longitudinal axis from the second magnet, and an excitation coil disposed radially outward of the first magnet and the second magnet.
Patent CA-3099891-A1 (CA)
Inventor: CALLANAN KEITH ANTHONY
IPC: E04G11/48
Filed: 2019-01-21
Abstract: An apparatus for use in construction to assist in the support of suspended concrete during at least a curing phase of the concrete. The apparatus comprising: a base member, a support member coupled to the base member and moveable relative to the base member between a first relative position ("first position") and a second relative position ("second position"), a biasing mechanism operatively coupled to the support member to bias the support member toward the second position, and a preloading mechanism operatively coupled to the support member to releasably lock the support member in a preloaded position relative to the base member at or proximal to the first position.
Patent CA-3100792-A1 (CA)
Title: Methods and compositions for treatment of alzheimer's disease
Inventor: ALKON DANIEL L
IPC: A61K31/365
Filed: 2019-05-17
Abstract: A method for treating Alzheimer's disease (AD) by administering to an AD patient a PKC activator, such as a bryostatin-1, without administering a NMDA receptor antagonist, such as memantine.
Patent CA-3101240-A1 (CA)
Title: Porte de cabine pressurisee d'aeronef a structure formee de poutres
Inventor: DEVILLEZ SEBASTIEN
IPC: B64C1/14
Filed: 2019-05-28
Abstract: Porte (1) de cabine pressurisée d'aéronef, comportant un panneau extérieur (2) et une structure (3) de porte. La structure (3) de porte comprend : - deux poutres circonférentielles (4) fixées sur les rebords latéraux de la porte (1); - une pluralité de poutres longitudinales (5) disposées sensiblement perpendiculairement entre les poutres circonférentielles (4) et fixées sur le panneau extérieur (2), chaque poutre longitudinale (5) s'étendant d'une poutre circonférentielle (4) à l'autre. Chaque poutre longitudinale (5) est un profilé ouvert dont l'ouverture est tournée vers le panneau extérieur (2), cette ouverture étant close par la face interne du panneau extérieur (2) sur laquelle est fixée la poutre longitudinale (5). Chaque poutre peut comporter un élément de redondance structurel.
Patent CA-3101842-A1 (CA)
Title: A method of digital signal feature extraction comprising multiscale analysis
Inventor: TERRAZAS GONZALEZ JESUS DAVID
IPC: H04L12/26
Filed: 2019-05-31
Abstract: A method of digital signal feature extraction comprises steps of: (a) segmenting samples of the digital signal to form a set of groupings each comprising a subset of the samples, with each grouping having endpoints spaced apart by a current grouping size; (b) applying an operator, which is associated with the desired feature to be extracted, to the subset of the samples of each grouping to derive a representative value therefor corresponding to the grouping size; and (c) repeating step a), but based on a different grouping size, and repeating step b) on the set of groupings formed based on the different grouping size, with the operator being adapted to correspond to the different grouping size. The set of groupings formed in step a) collectively includes all of the samples of the signal. One endpoint of at least one grouping is intermediate the endpoints of another one of the groupings.
Patent CA-3102229-A1 (CA)
Inventor: PORTELA RULDOLF GIOVANI
IPC: A01K31/22
Filed: 2019-06-17
Abstract: L'invention concerne un système de nidification de volaille qui comprend un logement de nid avec une plate-forme adjacente surélevée au-dessus de la surface du substrat environnant. La plate-forme a une surface supérieure et au moins une partie d'un périmètre de la plate-forme comprend un treillis métallique recouvrant un espace entre le substrat et la surface supérieure. Le treillis métallique est formé par une pluralité de brins comprenant un brin supérieur et un brin inférieur. Au moins une partie de la surface supérieure de la plate-forme est supportée par une pluralité de supports de plancher de plate-forme positionnés sur un périmètre de la plate-forme. Chacun de la pluralité de supports de plancher de plate-forme comprend un élément de renforcement, un capuchon supérieur sur une extrémité supérieure de l'élément de renforcement, et un capuchon inférieur sur une extrémité inférieure de l'élément de renforcement. Le capuchon supérieur a un mécanisme de fixation sur une partie supérieure de celui-ci, configuré pour interagir avec la surface supérieure pour verrouiller le support de plancher de plate-forme à la surface supérieure de la plate-forme de telle sorte que le support de plancher de plate-forme supporte la surface supérieure dans sa position surélevée au-dessus du substrat. Le capuchon supérieur a un loquet supérieur configuré pour interagir avec le treillis métallique et maintenir le treillis métallique en place, le loquet supérieur formant un creux orienté vers le haut pour recevoir le brin supérieur. Le capuchon inférieur a un loquet inférieur configuré pour interagir avec le treillis métallique et maintenir le treillis métallique en place, le loquet inférieur formant un arc orienté vers le bas pour recevoir le brin inférieur. Une longueur d'un espace de déplacement sous l'arc orienté vers le bas du loquet inférieur est supérieure à une longueur d'un espace de déplacement dans le creux orienté vers le haut du loquet supérieur.
Patent CA-3106610-A1 (CA)
Inventor: BEAN CHRISTOPHER
IPC: F01D15/10
Filed: 2019-07-17
Abstract: A power generation system includes one or more micro-turbine electric generators ("MTEGs"). The MTEGs include a housing having an inlet for receiving pressurized gas and an outlet for releasing expanded gas. The MTEGs also include a rotor, a user-replaceable nozzle for directing pressurized gas over blades of the rotor, and a stator for generating alternating current ("AC") responsive to rotation of the rotor. The power generation system also includes a programmable logic controller ("PLC") coupled to the MTEGs that operates flow control valves ("FCVs") coupled to the MTEGs to modulate the flow of gas to the MTEGs to generate output power suitable to support an electrical load. The system also includes power conversion circuitry configured to convert AC generated by the MTEGs to direct current ("DC") and to provide the DC to an electrical load. The system also includes a skid for mounting multiple and MTEGs and FCVs