Patent SG-11201810685W-A (SG)
Title: Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
Inventor: FORNASINI GIANFRANCO
IPC: A61K9/19
Filed: 2017-06-01
Abstract: ASPARAGINASESOLUTION PREPARATION PEGylation W O 18/0 17 190 A3 CLARIFICATION DIAFILTRATION! CONCENTRATION DILUTION STERILE FILTRATION & FILL INTO STERILE CONTAINER F STORE IN SFERILE .,A3 CONTAINER FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) WIP0 I PCT onion °nolo III m How VIII molio 111E11110 Il (10) International Publication Number WO 2018/017190 A3 (51) International Patent Classification: A61K 9/19 (2006.01) (21) International Application Number: PCT/US2017/035461 (22) International Filing Date: 01 June 2017 (01.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/344,256 01 June 2016 (01.06.2016) US 62/344,249 01 June 2016 (01.06.2016) US 62/344,252 01 June 2016 (01.06.2016) US (71) Applicants: BAXALTA INCORPORATED [US/US]; 1200 Lakeside Drive, Bannockburn, IL 60015 (US). BAX- ALTA GMBH [CH/CH]; Zaehlerweg 4, 6300 Zug (CH). (72) Inventors: FORNASINI, Gianfranco; c/o Troutman San- ders LLP, 875 Third Avenue, New York, NY 10022 (US). SOUKHAREVA, Nadejda; c/o Troutman Sanders LLP, 875 Third Avenue, New York, NY 10022 (US). PHIL- LIPS, Christopher; c/o Troutman Sanders LLP, 875 Third Avenue, New York, NY 10022 (US). (74) Agent: SULLIVAN, Nicole, R.; Troutman Sanders LLP, 875 Third Avenue, New York, NY 10022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: FORMULATIONS OF POLYALKYLENE OXIDE-ASPARAGINASE AND METHODS OF MAKING AND USING THE SAME (57) : Aspects of the invention include polyalkylene oxide-asparaginase compositions. In some instances, the composition is a lyophilized storage stable composition. In some instances, the lyophilized compositions include one or more of a buffer, a salt, and a sugar. Aspects of the invention further include methods of making the compositions. The compositions find use in a variety of applications, e.g., in the treatment of a neoplastic condition in a subject. [Continued on next page] WO 2018/017190 A3 MIDEDIMOMOI IIIII IIMOIIMIENIIMOINIDOHMOMMOMECIE Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 01 March 2018 (01.03.2018)