Patent SG-11201810101T-A (SG)
Title: A system and method for ultrasound-enhanced delivery of drugs
Inventor: SUEN WAI LEUNG LANGSTON
IPC: A61F9/00
Filed: 2017-05-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/198773 A2 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61F 9/00 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, PCT/EP2017/061983 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (22) International Filing Date: KM, ML, MR, NE, SN, TD, TG). 18 May 2017 (18.05.2017) (25) Filing Language: English Published: — without international search report and to be republished (26) Publication Language: English upon receipt of that report (Rule 48.2(g)) (30) Priority Data: 16170141.2 18 May 2016 (18.05.2016) EP (71) Applicant: SONIKURE HOLDINGS LIMITED ; 2/F, Kam Chung Commercial Building, 19-21 Hennessy Road, Wan Chai, Hong Kong, Hong Kong (CN). (71) Applicant (for MG only): WARD, Eliot Michael [GB/GB]; Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London EC2V 5DE (GB). Inventors: SUEN, Wai Leung Langston; 7D, Block 2, Fe- licity Garden, 111 Shaukeiwan Road, Hong Kong, Hong (72) Kong (CN). CHEUNG, Sin Hang Sarah; Flat E, 25/F Tower 2 Aria, 51 Fung Shing Street, Ngau Chi Wan, Hong Kong, Hong Kong (CN). ENGELS, Jan Frederik; Flat 6, 24/F, Block P, Amoy Gardens, Kowloon Bay, Hong Kong, Hong Kong (CN). Agent: WARD, Eliot et al.; Mewburn Ellis LLP, City Tow- er, 40 Basinghall Street, London Greater London EC2V = (74) 5DE (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = (84) ei en (54) Title: A SYSTEM AND METHOD FOR ULTRASOUND-ENHANCED DELIVERY OF DRUGS IN r..., (57) : A drug applicator for a system for ultrasound-enhanced delivery of at least one drug to a target site in a intraocular GP space, the system comprising a signal generating unit operationally connected to an ultrasound transducer, wherein the drug applicator ON comprises at least one space hold the drug, is made from a low ultrasound attenuation material, is configured to provide low ultrasound 1-1 ---. loss coupling of the system to the sclera, and is configured to be mechanically coupled to the system and further configured to be coupled Ir' to 1-1 the ultrasound transducer with low ultrasound loss. The signal generating unit and/or the ultrasound transducer are configured to © emit an ultrasound wave form in at least one application cycle, the application cycle comprising at least one ultrasound emitting event ei with a time duration TA and a waiting period with a time duration TW. C