baber/WOPTO huggingface dataset:
Patent SE-304526-B (SE)
Inventor: GIFFORD W
IPC: F25B9/00
Filed: 1960-06-15
Abstract: 938,182. Refrigerating. ARTHUR D. LITTLE Inc. June 15, 1960, No. 20992/60. Addition to 882,656. Class 29. In a modification of the process of the parent Specification, in which high pressure fluid in an expansible chamber is not allowed to do work on a piston but is released without previous rarefaction into the low pressure source, net refrigeration is stated to be obtained by working the hot end of the regenerator at a higher temperature than that which obtains in the high pressure source. The sources are connected cyclically to a cylinder having a displacer for transferring fluid through the regenerator. As shown, helium is compressed by compressor 192, admitted to a series of heatexchangers 154, 144, 162, 146, 164, 148 and 168 by valve 153 and liquefied by expansion at Joule-Thomson valve 172 into liquid collecting columns 174. Helium boiling off in the column at a low pressure cools the incoming high pressure gas in exchangers 168, 164, 162 and 154 before being recycled by the compressor. A heater 180 is provided. Heat exchangers 144, 146 and 148 are cooled by a working gas, which may be helium, and which undergoes the refrigeration cycle of the invention. With the displacer 116 lowered, the low pressure gas in chamber 111 is heated by connection with high pressure container 102 and transferred by upward movement of displacer 116 to chambers 126, 127 and 128 after cooling in regenerators 130, 132 and 134. When the displacer reaches its upper limit valve 110 is closed and valve 112 is opened, allowing the gas, cooled by expansion to cool the regenerators and heat-exchangers and return to the low pressure container 104 and chamber 111 as the displacer descends. The regenerators working above 50 K are filled with copper or bronze screening or perforated discs. Those working below 50‹ K are filled with lead balls. The displacer members 120, 121 and 122 are made of a resin impregnated fibrous material such as "Micarta" (Registered Trade Mark). In order to establish a stable temperature gradient in the regenerators the gas may enter them through supplementary regenerators which are filled with conductive plates or wire unable to support a temperature gradient and which may be connected with blocks of high thermal capacity (Figs. 11-13, not shown). The supplementary regenerators may be partially by-passed in one direction of gas flow but not in the other (Fig. 14, not shown). In order to make use of the space between the displacer and the walls of its containing cylinder for gas cooling, the heat capacity of the lower portions of the cylinder walls and/or the displacer may be increased by embedding lead rings or helices therein (Figs. 15, 16, not shown). In another form (Fig. 8, not shown), three regenerators are arranged within the bodies of three coaxial pistons acting as displacers.
Patent RS-50432-B (RS)
Title: Novel tetrahydropyridines, preparation method and pharmaceutical compositions containing same
Inventor: BARONI MARCO
IPC: A61P31/04
Filed: 2000-12-29
Abstract: The present invention relates to compounds of formula (I):in whichR1 represents a hydrogen or halogen atom, or a group CF3;R2 and R3 represent, independently, a hydrogen atom or a methyl group;n and n' each represent, independently, 0 or 1;* represents the positions of attachment;A represents N or CH;X represents a sulfur or oxygen atom;R4 and R5 represent, independently, a hydrogen atom or a (C1-C6) alkyl group;and also their salts or solvates, to a method for the preparation thereof and to the pharmaceutical compositions containing them.
Patent RS-50813-B (RS)
Inventor: STUTZMAN-ENGWALL KIM JONELLE
IPC: C12N15/60
Filed: 2003-01-31
Abstract: Polinukleotidni molekul koji sadrži nukleotidnu sekvencu koja je inače ista kao alel Streptomyces avermitilis aveC, sekvencu plazmida pSE186 (ATCC209604) koja kodira AveC genski produkt S.avermitilis ili nukleotidnu sekvencu SEQ ID NO: 1 aveC ORF S.avermitilis-a, ili njegovu varijantu koja uključuje jednu ili više tihih promena nukleotidne sekvence zahvaljujući degeneraciji (izrođenosti) genetičkog koda, ali koja dalje sadrži mutacije koje kodiraju kombinaciju supstitucija amino kiselina prema amino kiselinskim pozicijama u SEQ ID NO: 2 , tako da ćelije S.avermitilis soja ATCC 53692 u kojem je divlji tip aveC alela inaktiviran i koje eksprimiraju polinukleotidni molekul sa mutiranom nukleotidnom sekvencom, mogu da proizvedu odnos klasa 2:1 avermektina koji je smanjen u poređenju sa odnosom koji je dobijen ćelijama S.avermitilis soja ATCC53692 koje eksprimiraju samo divlji tip aveC alela, naznačeno time, da kada su klase 2:1 avermetkina cikloheksil B2:cikloheksil B1 avermektini, odnos klasa 2:1 avermektina je 0.20 do 0.17:1 i u kojima kombinacije supstitucija amino kiselina obuhvataju supstitucije i na D48 i G179 i gde kombinacija supstitucija amino kiselina sadrži kombinaciju odabranu iz grupe koju čine:(ao) D48E, A89T, L136P, G179S, E238D;(ap) D48E, A89T, L136P, K154E, G179S, E238D;(aq) D48E, A89T, S138T, A139T, K154R, G179S, V196A, P289L;(ar) D48E, A89T, S138T, A139F, G179S, V196A, E238D;(as) D48E, A61T, A89T, L136P, G179S, V196A, A198G, P289L;(au) D48E, A89T, L136P, G179S;(av) D48E, A89T, V120A, L136P, G179S;(aw) D48E, A61T, A89T, S138T, A139F, G179S, V196A, A198G, E238D; (ax) D48E, A61T, A89T, Gl 11V, S138T, A139F, G179S, V196A, E238D; (ay) D48E, A61T, A89T, S138T, A139T, G179S, V196A, E238D, P289L;(bd) D48E, A89T, S138T, A139T, G179S, V196A, E238D, P289L; i(be) D48E, A61T, A89T, S138T, A139F, G179S, V196A, E238DPrijava sadrži još 5 nezavisnih i 3 zavisna patentna zahteva.
Patent RS-50499-B (RS)
Inventor: LEADBETTER MICHAEL
IPC: A61K47/48
Filed: 2001-05-01
Abstract: Glikopeptid formule I:gde je:R1 odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, cikloalkila, supstituisanog cikloalkila, cikloalkenila, supstituisanog cikloalkenilaa, arila, heteroarila, heterociklusa i -Ra-Y-Rb-(Z)x; ili R1 je saharidna grupa opciono supstituisana sa-Ra-Y-Rb-(Z)x, Rf, -C(O)Rf, ili -C(O)-Ra-Y-Rb-(Z)x;R2 je vodonik ili saharidna grupa opciono supstitusana sa -Ra-Y-Rb-(Z)x, Rf, -C(O)Rf, ili -C(O)-Ra-Y-Rb-(Z)x;R3 je -ORc, -NRcRc, -ORa-Y-Rb-(Z)x, -NRc-Ra-Y-Rb-(Z)x, -NRcRc, ili -O-Re; ili je R3 azotom-vezan, kiseonikom-vezan, ili sumporom vezan supstituent koji obuhvata jednu ili više fosfono grupa;R4 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, -Ra-Y-Rb-(Z)x, -C(O)Rd i saharidne grupe opciono supstituisane sa -Ra-Y-Rb-(Z)x, Rf, -C(O)Rf, ili -C(O)-Ra-Y-Rb-(Z)x, ili R i R mogu da budu spojeni, zajedno sa atomima za koje su vezani, tako da obrazuju heterociklični prsten opciono supstituisan sa-NRc-Ra-Y-Rb-(Z)x;R5 je odabran iz grupe koja se sastoji od vodonika, halogena, -CH(Rc)-NRcRc, -CH(Rc)-NRcRe, -CH(Rc)-NRc-Ra-Y-Rb-(Z)x, -CH(Rc)-Rx, -CH(Rc)-NRc-Ra-C(=O)-Rx i supstituenta koji obuhvata jednu ili više fosfono grupa;R6 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, -Ra-Y-Rb-(Z)x, -C(O)Rd i saharidne grupe opciono supstituisane sa -Ra-Y-Rb-(Z)x, Rf, -C(O)Rf, ili -C(O)-Ra-Y-Rb-(Z)x, ili R5 i R6 mogu da budu spojeni, zajedno sa atomima za koje su vezani, tako da obrazuju heterociklični prsten opciono supstituisan sa -NRc-Ra-Y-Rb(Z)x;R7 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, -Ra-Y-Rb-(Z)x, i -C(O)Rd;R8 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, cikloalkila, supstituisanog cikloalkila, cikloalkenila, supstituisanog cikloalkenila, arila, heteroarila, i heterociklusa;R9 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, cikloalkila, supstituisanog cikloalkila, cikloalkenila, supstituisanog cikloalkenila, arila, heteroarila i heterociklusa;R10 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkenila, supstituisanog alkenila, alkinila, supstituisanog alkinila, cikloalkila, supstituisanog cikloalkila, cikloalkenila, supstituisanog cikloalkenila, arila, heteroarila, i heterociklusa; ili R8 i R10 su spojeni tako da obrazuju -Ar1-O-Ar2-, gde su Ar1 i Ar2 nezavisno arilen ili heteroarilen;R11 je odabran iz grupe koja se sastoji od vodonika, alkila, supstituisanog alkila, alkeni
Patent ZA-802344-B (ZA)
Title: Esters of allethrolone derivatives and carboxylic acids,process for their preparation and compositions containing them
Inventor: TECHE A
IPC: C07C69/612
Filed: 1980-04-18
Abstract: Novel esters of the formula    <IMAGE>  I'   wherein R1 and R2 are individually selected from the group consisting of carbamoyl and R1' and R2', R1' and R2' are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 13 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms and -CN, R3 and R3' are individually selected from the group consisting of hydrogen, halogen, alkenyl of 2 to 3 carbon atoms and alkyl of 1 to 3 carbon atoms, Y' is selected from the group consisting of   <IMAGE>  +TR  <IMAGE>  R4' and R5' are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, fluorine, bromine, chlorine and R4' and R5' together with the carbon atom to which they are attached form an optionally unsaturated hydrocarbon ring or heterocycle of 3 to 7 chain members and a heterocycle of the formula <IMAGE>  X is selected from the group consisting of sulfur and oxygen or R4' is cyano and R5' is phenyl or R4' is hydrogen and R5' is selected from the group consisting of cyano,   <IMAGE>  AlK is alkyl of 1 to 4 carbon atoms, the double bond in the 1- position of the vinyl side chain of formula (A) having (E) or (Z) configuration, R6 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkoxycarbonyl of 2 to 5 carbon atoms, the substituents on the cyclopropane ring of formula (A) and (C) have the cis or trans, racemic or optically active configuration, Z1 is alkyl of 1 to 4 carbon atoms, Z2, Z3 and Z4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms and halogen and the asymetric carbon of formula (D) may be (S) or (R) configuration or a racemic mixture thereof and the carbon atom in the 1- position of the alcohol moiety may have (R), (S) or racemic configuration having insecticidal properties and their preparations.
Patent ZA-807850-B (ZA)
Title: A ductile composite metal product
Inventor: ALLEGRA LOUIS
IPC: C23C2/12
Filed: 1980-12-15
Abstract: This invention is directed to an improved zinc containing metallic coated ferrous product, particularly sheet and strip, which is resistant to intergranular penetration by zinc and embrittlement of the ferrous base. Use of such zinc containing metallic coated ferrous product in elevated-temperature service, such as found with certain appliances and automotive exhaust components, is enhanced by the coated products of this invention. The resistance to embrittlement of the zinc containing metallic coated ferrous base, when subjected to elevated service temperatures, is achieved by the use of a high-phosphorus containing steel base. For a plain content steel base, a phosphorus content of at least 0.020% by weight, preferably at least 0.030%, and more preferably at least 0.039% was found sufficient to render such zinc-alloy coated ferrous base resistant to embrittlement by zinc. By use of such high phosphorus ferrous base, for the reception of a zinc containing alloy coating, an improved metallic coated ferrous product has been found which resists intergranular penetration by zinc and embrittlement of the ferrous base. Such coated product has extended service life at temperatures above about 450 DEG  F. (232 DEG  C.) and when restored to room temperature possesses a high degree of ductility.
Patent ZA-812541-B (ZA)
Title: Benzothiazole derivatives and salts thereof,processes for their preparation,and their use as sweetening agents
Inventor: GUENTER TRUMMLITZ
IPC: C07C205/58
Filed: 1981-04-16
Abstract: Compounds of the formula   <IMAGE>   wherein R1 is hydrogen or hydroxyl, and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as sweetening agents.
Patent ZA-848468-B (ZA)
Title: Processes for preparing hydroxyaromatic oligomers containing triazine groups and for preparing epoxy resins from the oligomers
Inventor: HEFNER ROBERT E JR
IPC: C07D251/34
Filed: 1984-10-30
Abstract: This invention pertains to a process for preparing hydroxyaromatic oligomers containing triazine groups. The process is characterized by (I) reacting (A) a material having an average of more than one aromatic hydroxyl group per molecule such as bisphenol A with (B) a cyanogen halide such as cyanogen bromide in the presence of (C) a base and recovering a mixture of cyanate-containing products and unreacted (A) materials; (II) trimerizing the product recovered in (I) in the presence of a trimerization catalyst such as cobalt naphthenate. This invention also pertains to a process for epoxidizing the product from step II by reaction with an epihalohydrin such as epichlorohydrin, dehydrohalogenation of the resultant product with a basic-acting material such as sodium hydroxide and recovering the resultant epoxy resin containing triazine groups.
Patent ZA-853099-B (ZA)
Title: Bleach products
Inventor: TAI HO TAN
IPC: C11D7/54
Filed: 1985-04-25
Abstract: A bleach product for use in the washing machine as an adjunct to a normal detergent powder or liquid comprises a closed bag containing a particulate bleach composition, the bag being formed of sheet material having pores large enough to render it water-permeable but small enough to confine the bleach composition within the bag. The bleach composition comprises sodium perborate with an activator : such as tetraacetyl ethylenebiamine or sodium octanoyloxybenzene sulphonate. Preferably at least 25 mole per cent of the perborate is in monohydrate form: this gives reduced malodour development on short storage.
Patent ZA-877153-B (ZA)
Title: Recombinant pseudomonas exotoxins:construction of an active immunotoxin with low side effects
Inventor: PASTAN IRA H
IPC: C07K16/28
Filed: 1987-09-23
Abstract: The present invention relates to various modified forms of Pseudomonas exotoxin exhibiting low toxicity to human or animal cells by itself but retaining its enzymatic activity. The modified Pseudomonas exotoxin of the present invention has ADP ribosylating activity but lacks all or part of domain II (responsible for translocation across cell membrane) of the native toxin. A preferred modified Pseudomonas exotoxin of the present invention further comprises a modification in the receptor binding domain IA of the native Toxin. Conjugates (immunotoxins) comprising a modified Pseudomonas exotoxin and a targeting carrier, such as an antibody or a growth factor, methods for producing a modified Pseudomonas exotoxin or conjugates thereof and compositions suitable for administration to a mammal for achieving targeted cytotoxin activity are also disclosed.
Patent ZA-877801-B (ZA)
Title: Heterocyclic derivatives
Inventor: KELLEY JAMES LEROY
IPC: C07D239/48
Filed: 1987-10-16
Abstract: The present invention provides a compound of formula (I): <CHEM> wherein R<1> is hydrogen, C1-4 alkyl, acetyl or formyl; R<2> and R<3> are the same or different and are hydrogen or C1-4 alkyl; R<4> is NR<1><1>R<1><2>; R<1><1>, R<1><2>, R<5> and R<6> are the same or different and are hydrogen, C1-4 alkyl or C1-12 acyl; R<7>, R<8>, R<9> and R<1><0> are the same or different and are hydrogen, halo, C1-4 haloalkyl, C1-4 alkyl and C1-4 alkoxy; and n is 2, 3, 4 or 5; m is o or an integer from 1 to 6; or a salt thereof, methods for the preparation of the compounds of the formula (I), intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of tumours.
Patent ZA-887593-B (ZA)
Title: A method of making a laminated tubular body
Inventor: LAJOVIC DUSAN SAVA
IPC: B29C49/24
Filed: 1988-10-12
Abstract: A laminated tubular body comprising; an outer layer and an inner layer which contacts the inner surface of the outer layer; wherein the outer layer is penetrated by at least one aperture and the inner layer extends into said at least one aperture.
Patent ZA-912036-B (ZA)
Title: Catalytic antibody components
Inventor: PAUL SUDHIR
IPC: C07K14/705
Filed: 1991-03-19
Abstract: Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.
Patent ZA-926337-B (ZA)
Title: Polypeptide analogues having growth hormone releasing activity.
Inventor: BOWERS CYRIL Y
IPC: A61K38/04
Filed: 1992-08-21
Abstract: Novel peptides of the formula A1-A2-Ala-Trp-DPhe-A5 are disclosed which promote the release of growth hormone when administered to animals. These peptides can be used therapeutically.
Patent ZA-931485-B (ZA)
Title: Stable conditioning shampoo containing cationic and suspended water-insoluble conditioning agents
Inventor: RIZVI RIAZ
IPC: A61K8/37
Filed: 1993-03-02
Abstract: A conditioning shampoo containing water; an anionic surfactant; a water-soluble cationic, preferably polymeric, conditioning compound; a liquid, water-insoluble conditioning compound having a viscosity at 25 DEG C less than about 20 centipoises, a specific gravity less than 1.0, preferably less than about 0.95, and a refractive index of at least about 1.4 at 25 DEG C; and a suspending agent for the water-insoluble conditioning compound; in a suitable carrier, has extended product stability, excellent cleansing properties and provides unexpected overall conditioning to human hair, particularly superior wet and dry combing properties. The composition effectively deposits the water-insoluble conditioning agent onto the hair to substantially improve dry comb and dry lubrication properties that the water-soluble cationic conditioning agent does not substantially improve.
Patent ZA-935488-B (ZA)
Title: Controlled release morphine preparation
Inventor: PERSSON CHRISTIANE
IPC: A61K9/52
Filed: 1993-07-29
Abstract: The present invention concerns an oral morphine preparation having essentially complete bioavailability and, for the major part of the dissolution, an essentially zero order and essentially pH independent release of morphine for a period of at least 8 hours, preferably at least 12 hours, during which a period less than 100% is dissolved. In the preparation, the morphine, in the form of an easily soluble salt, is present in a combination with a buffering agent in a preparation coated with a diffusion membrane.
Patent ZA-948393-B (ZA)
Title: Method and apparatus for tissue type recognition
Inventor: COPPLESON JOHN VICTOR MALCOM
IPC: A61B5/05
Filed: 1994-10-25
Abstract: A method and apparatus (21,150) is disclosed for identifying tissue which is suspected of being physiologically changed as a result of pre-cancerous or cancerous activity. The apparatus (21,150) includes a probe (1,10;151) configured to contact the tissue and which includes an arrangement (3-7,17-47;158-163) to subject the tissue to a plurality of different stimuli such as electrical, light, heat, sound, magnetic and to detect plural physical responses to the stimuli. The probe (1,10;151) connects to an analogue section (23;152) which buffers signals between the probe (1,10;151) and a processor (22;153). The processor (22;153) processes the responses in combination in order to categorise the tissue, and then compares the categorisation with a catalogue of expected tissue to identify the tissue, the processing occurring in real-time with an indication of the tissue type (eg. normal, pre-cancerous/cancerous, or unknown) being provided to an operator of the apparatus. <IMAGE>
Patent ZA-948877-B (ZA)
Title: 1,2-diaminocyclobutene-3,4-diones
Inventor: BUTERA JOHN ANTHONY
IPC: A61P9/08
Filed: 1994-11-09
Abstract: The compounds of the formula:    <IMAGE>  (I)  wherein: R1 and R2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl; A is an N-heterocycle which may be substituted by alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, alkylsulfonamido, alkylcarboxamido, nitro, cyano or carboxyl; or, A is a substituted phenyl group containing one or two substituents selected from cyano, nitro, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylsulfonamido, alkylcarboxamido, arylcarboxamido, alkylsulfone, perfluoroalkylsulfone, arylsulfone, chloro, bromo, fluoro, iodo, 1-imidazolyl or carboxyl; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.
Patent ZA-948913-B (ZA)
Title: Hypochlorite bleaching compositions
Inventor: AGOSTINI FRANCESCO
IPC: C11D3/02
Filed: 1994-11-10
Abstract: Stable liquid aqueous bleaching compositions are disclosed which comprise hypochlorite and a specific complexing agent or mixtures thereof selected from the group of polycarboxylic acid derivatives of pyridine or salts thereof. The compositions have a pH as is of from 11.5 to 14, and further comprise a Ca/Mg precipitation system. A method of treating fabrics with said compositions is also disclosed.
Patent AT-413853-B (AT)
Title: Internal combustion engine comprises an actuating element fixed by a blocking piston in its first position defining a first valve stroke, and having a second position that defines a shorter second valve stroke
Inventor: PRAESENT BERNHARD
IPC: F01L1/16
Filed: 2004-03-09
Granted: 2006-06-15
Abstract: Internal combustion engine comprises a variable valve-actuating device for a gas-exchange valve (2) actuated by a cam (3) and a tappet (4). The cam acts on the gas-exchange valve via an actuating element (5) that pivots between at least two positions perpendicular to the camshaft axis. The actuating element is fixed by a blocking piston (7) in its first position defining a first valve stroke. A second valve stroke defined by a second position of the actuating element is shorter than the first valve stroke. Independent claims are also included for: (1) Alternative internal combustion engines; and (2) Process for operating an internal combustion engine with preferably electrohydraulic fully variable valve drive.
Patent AT-410480-B (AT)
Title: Housing for electric heating device for flowing stream of fluid has two parts fitting together and incorporates flexure hinge joining two parts together
IPC: F24H9/02
Filed: 2001-03-23
Granted: 2003-05-26
Abstract: The housing (1) for the heater has flexure hinges (11) on its lower part (2). The lower part has vertical sides (4), the top edges of which accommodate the sides of the top portion. There is a hinged end portion (7), containing the water-heating element. There are fastening devices for the hinged portions.