baber/WOPTO huggingface dataset:
Patent AP-1383-A (AP)
Title: Heterocyclic compounds inhibiting angiogenesis.
Inventor: MAKK NANDOR
IPC: A61P35/04
Filed: 2000-08-02
Granted: 2005-04-05
Abstract: The invention relates to compounds of general formula (I) wherein R stands for a group of general formula -COOR1, -CONR2R3, -CONR4CONR4R5 or -CH2oR6, wherein R1 stands for substituted; or a C3-6 cycloalkyl group; R2 and R3 are identical or different and stand independently from each other for hydrogen atom or a C1-6 alkyl group which optionally may be substituted; a 5- or 6-membered cycloalkyl or a heteroaryl group; and their tautomers, solvates and the mixtures thereof and acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising compounds of general formula (I) as active agent. The angiogenesis-inhibitors according to the invention inhibit the neovascularisation in living tissues and as such can be used for preventing and inhibiting angiogenesis appearing in connection with tumour growth and for preventing the formation of tumour metastases.
Patent DO-P2003000767-A (DO)
Title: Derivados del acido isoftalico
Inventor: BECKER EVA-MARIA
Filed: 2003-11-26
Abstract: La presente invención se refiere a derivados de acido isoftalico, a un procedimiento para su preparación asi como a su use para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades en hombres y animates, especialmente de enfermedades cardiovasculares.
Patent DO-P2009000228-A (DO)
Title: Compuestos de quinolina apropiados para tratar trastornos que responden a la modulacion del receptor de serotonina 5-ht6
Inventor: UNGER LILIANE
IPC: C07D401/04
Filed: 2009-09-22
Abstract: La presente invención se relaciona con nuevos compuestos de quinolina. Los compuestos poseen propiedades terapeuticas valiosas y son apropiados, en particular, para tratar enfermedades que responden a la modulación del receptor de serotonina 5-HT6. R es una unidad de la formula donde A, R1 a R4 son segun se define en las reivindicaciones y en la memoria descriptiva, n es 0, 1 ó 2; m es 0, 1, 2 ó 3; Ra, Rb se seleccionan independientemente entre el grupo que consiste en halógeno, CN, C1,-C4-alquilo, Ci-C4-haloalquilo, C,-C4-alcoxi, Cl-C4-haloalcoxi, C(O)Raa, C(O)NRccRbb y NRccRbb; X es CH2, C(O), S, S(O) o S(O)2; que esta situado en la posición 3 ó 4 del anillo quinolina ; Ar es un radical Ar1, Ar2-Ar3 o Ar2-O-Ar3, donde Ar1, Ar2 y Ar3 se seleccionan independientemente entre si, del grupo que consiste en arilo o heteroarilo donde las unidades arilo o heteroarilo pueden no estar sustituidas o pueden contener 1, 2, 3 sustituyentes Rx, donde Rx es como se define en las reivindicaciones y en la memoria descriptiva; y sales de adición acida toleradas para el use fisiológico y sus N-óxidos.
Patent DO-P2015000077-A (DO)
Title: Derivados de pirrolotriazinona como inhibidores de pi3k
Inventor: SOLA MONTSERRAT ERRA
IPC: C07D519/00
Filed: 2015-03-30
Abstract: Se describen nuevos derivados de pirrolotriazinona que tienen la estructura química de fórmula (I); así como un procedimiento para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia como inhibidores de Fosfoinositido 3-quinasas (PI3Ks).
Patent EC-SP11011440-A (EC)
Title: Combinación antitumoral que comprende ave8062 y sorafenib
Inventor: DEMERSON CHRISTOPHER
IPC: A61K31/167
Filed: 2011-11-07
Abstract: La invención se refiere a una combinación farmacéutica antitumoral que comprende AVE8062 de fórmula (I) y sorafenib de fórmula (II), pudiendo estar estos dos agentes antitumorales en forma e base o en forma de una sal de un ácido farmacéuticamente aceptable.
Patent EE-200100482-A (EE)
Inventor: MANSSILA JARKKO
IPC: H04M3/46
Filed: 2000-03-15
Abstract: A method for defining the target number used in the call control of an intelligent-network service, according to the choice of the customer, in which method a telecommunications link is formed between the customer's terminal device and the control user-interface of the intelligent-telephone-network service, the target number selected by the customer being received by means of the telecommunications link formed. According to the invention, in such a method, the target number is received in a primary form, the target number in the primary form being converted into a target number in a secondary form, and the target number in the secondary form being defined as a target number to be supplied for call routing. The publication also discloses a call-control method based on the conversion of the number.
Patent EE-200200502-A (EE)
Inventor: PLETZER STEFAN
IPC: E04F15/04
Filed: 2000-08-01
Abstract: The invention relates to a panel connection, particularly for flooring panels, having a groove (34) that is embodied at a side edge (3); a spring (32) that is embodied at a side edge (4); a depression (35) that is embodied in the groove (34) and has an interlocking surface (16); an interlocking element (33) that is embodied at the spring (32) and has an interlocking surface (27); and fitting surfaces (12, 22), which are embodied in the groove (34) and at the spring (32) and serve as abutments for the interlocking surfaces (17, 27). The properties of interlocking and orientation stability are improved in that the groove (34) has fitting surfaces (14, 15), which extend parallel to the top side (5), in the region of the groove bottom (7), and the spring (32) has fitting surfaces (24, 25), which extend parallel to the top side (9), in the region of the end surface (8), with the fitting surfaces (14, 24; 15, 25) resting against one another in the interlocked state of the connection.
Patent EE-200300067-A (EE)
Inventor: MOESSNER FRANK
IPC: H01R24/58
Filed: 2001-07-26
Abstract: An electrical connector includes a connector housing and a printed circuit board with two sets of contact elements. The first set of contact elements is located on the front face of the printed circuit board and protrudes into an opening in the plug connector housing. The second set of contact elements is located on the rear face of the printed circuit board. The contact elements of the second set are configured to form insulation-displacement contacts. The plug connector also includes a cable manager which has a continuous opening and is configured on the front face with guides for cores or wires which are intended to make contact with the insulation-displacement contacts. The guides in the region of the insulation-displacement contacts are configured with recessed receiving elements or holders for the insulation-displacement contacts, and the cable manager can be latched to the plug connector housing.
Patent GB-189419917-A (GB)
Title: Improvements in Stretching Frames for Woven or Knitted Garments and the like.
Inventor: GODDARD CHARLES
Filed: 1894-10-19
Granted: 1895-09-21
Abstract: 19,917. Goddard, C. Oct. 19. Drying-frames.-An appliance for stretching woven or knitted garments, such as vests, jerseys, bodices, or combination garments, to prevent shrinkage after washing or at other times, consists of a cross-bar B, Fig. 1, which is inserted in the arms of the vest or like garment and to which is attached a bar S adjustable in position according to the length of the garment to be stretched. Attached to this bar is another cross-bar H, in which are notches or other means to engage the ends of cords C attached to the end of the bar B, and which are passed inwards through the sleeves and down the inside of the garment and attached to the bar H so as to stretch the garment sideways. Fig. 2 shows a modifled form of apparatus for stretching combination garments. It has two bars S, S<1> for each leg, and each of these has an out- standing adjustable bar P, P<1> attached to it, to stretch the garment at the hips.
Patent GB-189703231-A (GB)
Title: Improvements in Collecting Boxes and Bags for Coins, Letters, and other Objects.
Inventor: FUCHS GUSTAV
Filed: 1897-02-06
Granted: 1897-07-10
Abstract: 3231. Fuchs, G. Feb. 6. Locks, key fastenings.-Relates to letter, coin, &c. collecting-boxes and to a portable collecting- bag constructed so that the contents of the former may be discharged into the latter without being accessible to the person carrying the bag. The base-plate A of the box carries a slide a held in the closed position shown by a pin a<3> engaging in slots in spring tumbler-plates b. The coverplate of the collecting-bag is fitted with similar mechanism, and when the box is placed upon it a fixed key enters a slot b<5> and acts upon the tumblerplates b so that the slide a may be drawn out by hand until an opening a' therein registers with an opening A<1> in the plate A. The movement of the slide a causes a pivoted key d to move into position to operate the tumbler-plates of the cover-plate of the bag so that a slide thereon may be moved to cause two openings similar to a', A<1> to register, whereupon the coins &c. can drop from the box to the bag. The plate a at this time engages in grooves in the sides of the tumbler-plate case on the bag-plate and fastens the latter to the box ; the slide on the bag-plate also causes a hook device to enter an aperture b' and grasp the plate A. The box contains a funnel or shoot, and may have the shape of a matchbox stand. The bag may be connected with the case enclosing the locking-device by a hinge arrangement and secured by a lock, or the bottom of the bag may be constructed like the bottom of the box so that it may be emptied into a stationary till fitted with mechanism similar to that on the top of the bag.
Patent GB-189705047-A (GB)
Title: Improvements in or connected with Hearths for Brazing and the like purposes.
Inventor: JUDGE ROBERT JOSEPH
Filed: 1897-02-25
Granted: 1898-01-01
Abstract: 5047. Judge, R. J. Feb. 25. Brazing &c. furnaces. - Relates to furnaces chiefly intended for use in the manufacture of kerbs, window frames, and other structures in the brazing &c. of which the fire is required at various points. Fig. 1 shows in elevation, and Fig. 2 in plan, a framework 6 along which the brazing- hearths 7 are shifted as required. The blast is carried to the hearths from a standard 9 by flexible pipes 11. In a modification, the blast is carried through the tubular framing from which, by flexible pipes, it is taken to the hearths. The framework may be extended as shown in dotted lines in Fig. 2.
Patent GB-189714087-A (GB)
Title: Improvements in Journal-bearings.
Inventor: TRIPP WILLIAM JAY
Filed: 1897-06-09
Granted: 1898-01-22
Abstract: 14,087. Tripp, W. J. June 9. Axle-boxes.-Fig. 11 shows the invention as applied to a shaft bearing. The balls A roll in annular channels of square section between the -grooved bearing parts B, B<1>. Either of the parts B, B' may be made up of segmental rings 20, 21, and means may be provided for adjusting these rings. The balls may be mounted so as to revolve on spindles a mounted in rings C, C'. In order to permit a slight lateral movement of the shaft K, the inner bearing part B<1> may be mounted in an annular groove k somewhat broader than itself.
Patent GB-189714346-A (GB)
Title: Improvements in Bicycle Bells.
Inventor: PARTINGTON DAVID
Filed: 1897-06-14
Granted: 1898-06-11
Abstract: 14,346. Partington, D. June 14. Velocipede bells.-An arm A is pivoted at h on a clamp K, K<1> on the front fork of a bicycle, and is normally held against a stop i by a spring c. The arm carries the domes a and the hammer shaft g, the latter having a roller f at its outer end. By operating a cord b from the handle-bar, the roller is brought into contact with the front wheel, causing the bell to ring as long as the cord is pulled and the bicycle is in motion. The arm is restored by the spring c.
Patent GB-189714907-A (GB)
Title: Improvements in Apparatus for Preserving Organic Bodies.
Inventor: BELFORT LUDOVIC AUGUSTIN MARIE
Filed: 1897-06-19
Granted: 1897-10-09
Abstract: 14,907. Belfort, L. A. M. D. de. June 19. Preserving.-Relates to an apparatus for use in preserving organic substances by means of the combined action of carbonic acid and methylal in presence, in certain cases, of an electrical current. The apparatus comprises a cylinder A for generating carbonic acid. This cylinder is fitted with stirring-blades, and is surmounted by a cylinder B<1> containing hydrochloric acid and fitted with a valve by means of which the supply of acid to the carbonate of soda in the cylinder A can be regulated. The cylinder A is connected to receivers R<1>, R<2>, R<3>, R<4> in which the substances to be preserved are placed. The apparatus also comprises a force-pump, not shown in the Figure, by means of which water, charged with one-fourhundredth part of methylal to which a proportion of sodium chloride is added, is forced into the receivers after the substances have been treated with carbonic acid under pressure. Intermediate vessels are provided to hold the carbonic acid from the receivers when it is driven out by the subsequent process. Arrangements are made to pass an electric current through the substances under treatment by the solution of methylal. The various vessels are all connected by suitable pipes with cocks, and are fitted with other accessories. The substances after treatment are removed from the receivers and then suspended in a well-ventilated place.
Patent GB-189730207-A (GB)
Title: Improvements in Flushing Tanks.
Inventor: FRANCOIS VICTOR
Filed: 1897-12-21
Granted: 1898-11-05
Abstract: 30.207. Francois, V. Dec. 21 Ball and float valves for water-waste preventers. The ball m is connected to the end of a lever n pivoted at l<2>. Upon the lever o of the float o' is mounted adjustably a collar p with laterallyprojecting pins q, r, between which the lever n passes with a small amount of play.
Patent GB-189802289-A (GB)
Title: Improvements in Pneumatic or Air Pumps.
Inventor: PULSFORD EMILE
Filed: 1898-01-28
Granted: 1898-12-03
Abstract: 2289. Pulsford, E. Jan. 28. Exhausting.-T w o o r m o r e pumps of graduated volume are used for exhausting in stages ; in Fig. 1, three are shown, the pistons B being driven by cranks at 180‹ with each other. The pumps oscillate about a shaft 0 and are single-acting, the barrels being open at the top and the pistons sealed by a layer of oil above them. The distributing valves H, H<1>, H<2> are of the oscillating-disc type, and are operated by friction clips M, M', M' on the piston-rods which slide in the valve rods J, J', J<2> and move them between the limits of the stops K, L, K<1>, L<1>, K<2>, L<2>. The valves are immersed in an oil bath G to prevent leakage. Stationary barrels may be used instead of oscillating, and the relative strokes of the pumps may differ instead of their diameters.
Patent GB-189803067-A (GB)
Title: An Improved Valve or Draw-off Tap.
Inventor: BARKER EDWYN JOHN
Filed: 1898-02-07
Granted: 1898-04-16
Abstract: 3067. Barker, E. J. Feb. 7. Lift valves; repairing, facilitating.-The valve a is connected to and actuated by means of a socket piece c, which is screwthreaded to engage with the casing and provided with a handle g. When the valve a is lowered so as to connect the inlet hand outlet e, the plug f which rests on the said valve is lowered at the same time; thus, if the socket c and valve a be removed, the plug f descends and closes the opening b, thereby facilitating repairing.
Patent GB-189803196-A (GB)
Title: Improvements in Paper Bag Machines.
Inventor: BRAINARD AUSTIN
Filed: 1898-02-08
Granted: 1898-03-19
Abstract: 3196. Brainard, A. Feb. 8. Paper bags.-In a machine for making squarebottom paper bags, the paper is taken from a continuous roll and formed into a tucked tube which is cut off in lengths to form the bags. The bottoms are then folded, pasted, and closed, and the bags discharged from the machine. Fig. 4 shows a sectional side elevation. The machine is driven by a pulley on the shaft 27 which is connected by suitable gearing with the various parts. The paper tube 21 as delivered from the former passes through drawing-rolls 42, 46, 32, 36, and is cut off in lengths by a revolving arm 50 and a serrated cutter 51. The blank is caught by a revolving cylinder 55, which carries it past the folding, pasting, and closing devices, and discharges the finished bag at one side by the rolls 127, 128 and bands 125, 126, while receiving a blank at the other side. The cylinder is cut away at 55<a> and 55<b>, to allow of the turning in of the plates 56 hinged at 57. The blanks are held on the plates by clips 61 and by fingers 67, Fig. 15, entering the tucks in the paper tube. The clips, fingers, and plates are actuated by cams fixed to the machine framing. The folding is done by a plate 75 and fingers 83 which turn on a shaft 75<b> and fold the bottom of the bag as in Fig. 15, which shows the bag just before leaving the folder. The paste is delivered by the sector 95 revolving on the shaft 96 and supplied from the paste-box 104. The closing creases are made at the same time by the edges 106, 107. The rear corner R at the bottom of the bag is turned over by fingers carried on the cylinder and actuated by cams on the machine framing. The leading corner L, as released from the clip 61, is caught by the bar 124 and doubled over by the reciprocating blade 115, which also transfers the bag to the delivery bands 125, 126. The machine may also be arranged with a reciprocating instead of a revolving conveyer.
Patent GB-189803346-A (GB)
Title: Improvements in and in the Manufacture of the Bodies of Inflating Valves for Pneumatic Tyres.
Inventor: SANGSTER CHARLES THOMAS BROCK
Filed: 1898-02-10
Granted: 1898-12-03
Abstract: 3346. Sangster, C. T. B. Feb. 10. Making wheel tyres.- The body of a wood valve for pneumatic tyres is formed to have a uniform external diameter, dispensing with the usual contraction at the valve seating. This is effected by placing a tubular blank on a mandrel with a reduced tip, and forcing it through a die. This thickens the metal at one end a while retaining external uniformity. The head is swelled over, and the thickened end bored, as indicated in dotted lines, to form the valve seat b. The body is then screwed, slotted, and finished off to the ordinary form.
Patent GB-189805188-A (GB)
Title: An Improved Device or Cover for Protecting Thread and the like Wound on a Card.
Inventor: HADDAN REGINALD
Filed: 1898-03-02
Granted: 1898-04-23
Abstract: 5188. Haddan, R., [Picavet, L.]. March 2. Bobbin cases.-For protecting thread or the like wound on a card, a device or cover is provided consisting of a strip E, Fig. 4, which is bent along the line X-Y as shown in Fig. 3. The spindle on which the cord or bobbin of thread is mounted passes through the perforations A in the cover, which may also have perforations J for viewing the thread. The thread@s withdrawn through a slit e at the base. A handle R may be provided, which may be also used for suspension. In a modification, the cover may be in two parts.
Patent GB-189808310-A (GB)
Title: Improvements in Calendering Machines.
Inventor: DOWNHAM JOHN
Filed: 1898-04-07
Granted: 1898-05-14
Abstract: 8310. Downham, J. April 7. Ironing-machines; mangling-machines. -Rentes to means for raising the upper roller from the lower when necessary to allow the passage of thickened portions of articles such as window blinds. The pulley a, driven in any suitable manner, runs loosely on the shaft b and may be connected with it by operating the clutch c by means of the lever c'. When this is done, the shaft f is driven by means of the gear-wheels d, e, and cams g raise the stirrups h of the upper cylinder i. When the highest position is reached, the projection k on the shaft f disconnects the clutch c and the roller is kept in its highest position till the lever c<2> is again operated ; when the roller has been lowered the piece e operates to disconnect the clutch.
Patent GB-189809919-A (GB)
Title: Improvements in Advertising Apparatus.
Inventor: MALES JUDSON LEWIS
Filed: 1898-04-30
Granted: 1899-03-25
Abstract: 9919. Males, J. L. April 30. Advertising. - The casing a, which has a removable end c and a glazed front, is fitted with adjustable brackets e, h, on which are mounted shafts g, m, having wheels or rollers r, r<1>, t, t<1> over which pass endless belts s, s<1> attached to which is an endless apron carrying the advertisement matter s<5>. The ends of the bands s, s<1> are adjustably secured by a button-and-slot connection, and the brackets e can be adjusted to the size of the bands by means of a screw n. Rods p are also adjustably secured to the brackets. The advertisements are changed by means of a crank handle g<1>. The device may be placed on a stand or suspended.
Patent GB-189811013-A (GB)
Title: Improvements in Knobs and Handles for Mortise and Rim Locks and the like.
Inventor: COLLINS FREDERICK HOWARD
Filed: 1898-05-14
Granted: 1899-03-18
Abstract: 11,013. Collins, F. H. May 14. Knobs, attaching.-Relates to the introduction of a ball bearing between the neck of the knob and the rose of a mortise or rim lock or the like. A groove is made in the rose C to serve as a race for the balls D. A corresponding race is made in the neck B of the knob. The balls are inserted by removing the screwed plate A.
Patent GB-189811920-A (GB)
Title: A New or Improved Double Ball Bearing.
Inventor: HEINRICH HANS
Filed: 1898-05-25
Granted: 1898-07-16
Abstract: 11,920. Heinrich, H. May 25. Ball bearings.-Two distinct sets of balls are employed at each end of the bearing. The inner sets work between the cones c on the axle a and the sleeve b surrounding it. The outer sets work between cones formed on the sleeve and cups f in the hub h.
Patent GB-189821471-A (GB)
Title: A Process for the Preparation of Piperidine and Dihydroquinoline.
Inventor: PIP WILHELM
Filed: 1898-10-12
Granted: 1899-09-09
Abstract: 21,471. Pip, W. Oct. 12. Piperidine and dihydroquinoline are produced electrolytically in good yield from pyridine and quinoline, respectively, under the following conditions, viz.:-(1) The proportion of sulphuric or other acid, such as hydrochloric acid, present in the solution should be four equivalents of the acid to one of the base ; (2) the anode and cathode should both be lead, or, less advantageously, both may be carbon, or the cathode may be mercury or silver ; and (3) the acid and the other materials used, for example for diaphragms, should be as free as practicable frcm metallic salts.
Patent GB-189902600-A (GB)
Title: Improvements in Drills.
Inventor: KUHNE ERNEST
Filed: 1899-02-06
Granted: 1899-12-16
Abstract: 2600. Kuhne, E. Feb. 6. Drilling.-A drill, more particularly designed for drilling or boring into the soil for the removal of earths or minerals, has a conical head a with spiral backed-off cutting-lips a<2>. The upper end is slightly shouldered to receive the serrated end b<1> of a tube b, the parts being held together by screws c. The channels a<1> between the lips convey the borings into the tube, which has a discharge orifice b<2>, and a cap d to receive the boring-rod.
Patent GB-189902668-A (GB)
Title: Improvements in Wire Fence.
Filed: 1899-02-06
Granted: 1899-12-02
Abstract: 2668. Wise, W. L., [Manchee, J. W.]. Feb. 6. Fencing.-Droppers of V-section have slits A to receive the wires C, the slits being shaped as shown to jam the wire. The slits are alternately formed with the ends B upwards and downwards as shown.