baber/WOPTO huggingface dataset:
Patent CA-3140427-A1 (CA)
Title: Slack adjuster for a brake system with increased take-up capacity
Inventor: Koziol Michael Anthony
IPC: B61H15/00
Filed: 2016-11-16
Abstract: A slack adjuster for use with a railway braking system which has an increased let-out length that enables the use of brake shoes having an increased thickness. The slack adjuster includes at least one of a dual spring and canister assembly, an external yoke trigger, or a combination of both a dual spring and canister assembly and an external yoke trigger. A  method of retrofitting a truck mounted brake system is provided, in which the slack adjuster is positioned within the brake system in order to increase the let-out length while maintaining a predetermined spatial envelope within the brake system. The slack adjuster has an increased let-out length enabling the use of thicker brake shoes without requiring modification of the interacting components of the truck mounted brake system since the overall size of the slack adjuster remains the same.
Patent CA-3143428-A1 (CA)
Title: 8-amino-3-substituted-imidazo(1,5-alpyrazine and use thereof as inhibitors of bruton's tyrosine kinase
Inventor: HONIGBERG LEE
IPC: G01N33/53
Filed: 2008-03-27
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
Patent CA-3147847-A1 (CA)
Title: Arrangement for protecting against unauthorized intervention in a containment using a work glove
Inventor: GEISER CHRISTOPH JOSCHI
IPC: B25J19/06
Filed: 2020-07-23
Abstract: In the arrangement provided for protecting against unauthorized intervention in a containment (1) using a work glove (3, 4) through an access (24) present in a port flange (2), the work glove (3, 4) is conventionally installed at the port flange (2), with the result that the operator can enter the working chamber (11) of the containment (1) in a protected manner. A multiplicity of port flanges (2) are usually mounted on the containment (1) and a work glove (3, 4) is fastened in each case to the respective port flange (2). Machinery (13) for processing material to be treated is often set up in the working chamber (11). In order to temporarily block the access (24), a shut-off part (5) which can be moved into a blocking position and an open position is provided. In order to record personal data relating to the operator (9), the arrangement has a capture unit (62) which has a connection to a microcontroller (64) in order to issue a switching command to an activator (69) if there is correspondence between the captured personal data and the data in the microcontroller (64), as a result of which the shut-off part (5) can be brought into the blocking position or can be moved therefrom into the open position and the access (24) is therefore blocked or accessible. The data from the microcontroller (64) are directly stored therein or come from an external control unit (8).
Patent CA-3150332-A1 (CA)
Title: Organic polymeric compositions
Inventor: ARNOLD MICHAEL JOHN
IPC: C08G61/10
Filed: 2020-09-08
Abstract: A polymer comprising recurring units derived from organic unsaturated planar ring monomers. The recurring units are stacked, linked to one another by linkers, and are capable of undergoing oxidation and/or reduction, and the polymer is electrically conducting.
Patent CA-3150922-A1 (CA)
Title: Reactive metal sealing elements for a liner hanger
Inventor: GRECI STEPHEN MICHAEL
IPC: E21B33/12
Filed: 2019-12-24
Abstract: Methods for treating a wellbore. An example method includes positioning a conduit in the wellbore. The conduit is a liner hanger or a tie-back liner. The conduit includes a conduit body and a reactive metal sealing element disposed on the conduit body. The reactive metal sealing element includes a reactive metal having a first volume. The method further includes contacting the reactive metal with a fluid that reacts with the reactive metal to produce a reaction product having a second volume greater than the first volume. The method further includes contacting a surface adjacent to the reactive metal sealing element with the reaction product.
Patent CA-3153789-A1 (CA)
Title: Photogrammetric measurement of body dimensions using patterned garments
Inventor: COOPER SIMON
IPC: G06T7/62
Filed: 2020-03-19
Abstract: Measurement apparatus (20) includes a garment (24, 26, 140, 160) including an elastic fabric (27) having a predefined pattern (28) extending across a surface thereof and configured to be worn over a part of a body of a subject (22), such that the elastic fabric stretches across the part of the body. A camera (30, 80) is configured to capture images of the pattern while contacting and traversing across the surface of the fabric while the subject wears the garment. At least one processor (32, 36, 60) is configured to process the images captured by the camera at multiple locations on the surface of the fabric so as measure a local deformation of the pattern at the multiple locations due to stretching of the fabric, and to compute a dimension of the part of the body responsively to the measured deformation.
Patent CA-3156597-A1 (CA)
Title: Dispersion de polymere comprenant de l'hemicellulose
Inventor: MIETTINEN PAIVI
IPC: C09D125/04
Filed: 2020-10-28
Abstract: La présente invention concerne une dispersion de polymère pouvant être obtenue par réaction de polymérisation radicalaire de l'hémicellulose avec un ou plusieurs monomères à insaturation éthylénique. L'invention concerne également des produits de papier revêtus, le revêtement étant préparé à l'aide de la dispersion de polymère, et l'utilisation de la dispersion de polymère en tant qu'agent d'encollage et de revêtement d'un papier, d'un carton et similaire.
Patent CA-3157599-A1 (CA)
Inventor: WADDINGTON GORDON
IPC: A61B5/00
Filed: 2020-11-06
Abstract: L'invention concerne un appareil pour réaliser des évaluations combinées de fonctions vestibulaires et somatosensorielles, comprenant : une unité de base portable comprenant : une plateforme mobile pouvant tourner au moins partiellement autour d'un axe de rotation ; lors de l'utilisation, un utilisateur se tient avec les deux pieds sur la plate-forme mobile ; un mécanisme d'arrêt réglable pour ajuster une étendue à laquelle la plate-forme mobile peut tourner dans au moins une direction par rapport à un plan horizontal ; et un dispositif de commande pour commander le mécanisme d'arrêt réglable pour ajuster sélectivement l'étendue à laquelle la plate-forme mobile est mise en rotation par l'une d'une pluralité de quantités mesurables discrètes sur la base d'un signal de commande ; un casque d'occlusion visuelle porté par l'utilisateur, le casque comprenant un dispositif d'enregistrement d'une réponse de fonction vestibulaire en réponse à un test de fonction vestibulaire.
Patent CA-3160054-A1 (CA)
Title: Medication infusion devices, systems, and methods
Inventor: ORONSKY BRYAN
IPC: A61B5/15
Filed: 2020-12-11
Abstract: Devices, systems, and methods for medication infusion are described herein. In some embodiments, a system includes a patient access subassembly, a first fluid reservoir, a second fluid reservoir, and an assembly. The assembly can have a first configuration in which the patient access subassembly is in fluid communication with the first fluid reservoir via a first tube, a second configuration in which the first fluid reservoir is in fluid communication with the second fluid reservoir, and a third configuration in which the first fluid reservoir is in fluid communication with the patient access subassembly via a second tube, the first fluid reservoir fluidically isolated from the first tube in the third configuration.
Patent CA-3161872-A1 (CA)
Inventor: NGO KATHY
IPC: C12N9/22
Filed: 2021-01-17
Abstract: This invention provides methods and systems for enhancement of protein production from mammalian cell lines in a dmg inducible manner. The methods described herein can be used to generate a protein production cell line wherein the gene coding the protein product of interest is inserted into specific safe harbor loci (SHL) within the cell's genome and the gene copy number is induced to amplify by the use of an antibiotic inducer. The method enables for the conditional activation of the dmg inducible transposase. The dmg inducible gene amplification method described herein effectively functions as a molecular dial: combining dmg-inducible homologous recombination and conditional gene activation to fine-tune gene amplification in mammalian systems.
Patent CA-3162992-A1 (CA)
Inventor: CHUPAK LOUIS S
IPC: A61K31/4709
Filed: 2020-12-22
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK? ) and diacylglycerol kinase zeta (DGK? ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
Patent CA-3163136-A1 (CA)
Title: System and method for salt holding integratable pillow
Inventor: WIESINGER PAULETTE K
IPC: B32B5/30
Filed: 2020-12-29
Abstract: A system and method for a salt holding integratable pillow having wool infused with different types of salts, particularly Pharmaceutical grade salt ground into a powder and essential oils that may be integrated into masks, scrubbing sleeves used by athletes and other people for performance, baby toys, cat toys for asthmatic felines, small pillows, pillow cases acting as a salt holding device, feed bag styles having salt holding devices for horses and other animals.
Patent CA-3163143-A1 (CA)
Title: Procede, dispositif et machine pour calculer un indice representatif des proprietes de materiau d'un materiau du type osseux
Inventor: COSMI FRANCESCA
IPC: G06T7/00
Filed: 2020-12-23
Abstract: Procédé, dispositif et machine pour calculer un indice représentatif des propriétés d'un matériau du type osseux d'un individu à soumettre à des essais, en particulier, le procédé comprenant une première étape d'acquisition pour acquérir au moins une image comprenant une pluralité d'unités élémentaires d'un échantillon du matériau, une étape de génération prévue pour générer une grille d'éléments géométriques élémentaires, ou des cellules, qui est associée, en particulier superposée à, ladite image, une étape de traitement d'image (12) dans laquelle il est prévu de calculer au moins le module élastique apparent (E*) et un coefficient de densité (C) du matériau, en fonction de valeurs caractéristiques de chaque cellule, et une étape de calcul (14) pour calculer l'indice représentatif des propriétés d'un matériau, l'indice étant une fonction de la valeur du réseau élastique apparent (E*) de la contribution du coefficient de densité (C).
Patent CA-3163510-A1 (CA)
Inventor: JOHANSSON ANDERS
IPC: A61K9/00
Filed: 2019-12-06
Abstract: L'invention concerne une composition comprenant une pluralité de particules d'un diamètre moyen en poids, nombre, ou volume, qui est compris entre 10 nm et environ 700 µm, lesdites particules étant constituées de : (a) un noyau solide, lequel noyau solide comprend de préférence un agent biologiquement actif; (b) une ou plusieurs couches discrètes entourant ledit noyau, lesdites une ou plusieurs couches comprenant chacune au moins un matériau de revêtement séparé; et (c) une couche de recouvrement finale d'un matériau de revêtement, ladite couche de recouvrement entourant et/ou encapsulant ledit noyau et lesdites couches de matériau de revêtement appliquées précédemment, et ladite couche finale étant d'une épaisseur qui est inférieure auxdites couches précédemment appliquées. Lesdites couches (b) et (c) sont de préférence appliquées au moyen d'une technique de revêtement en phase gazeuse, telle qu'un dépôt de couche atomique. Lorsque les noyaux comprennent un agent biologiquement actif, les compositions peuvent permettre la libération retardée ou prolongée dudit agent actif sans effet de salve.
Patent CA-3163690-A1 (CA)
Inventor: SJOBLOM ANDERS
IPC: C12M1/00
Filed: 2021-02-02
Abstract: The present disclosure generally relates to a pretreatment arrangement (100) for pretreatment of lignocellulosic biomass. The pretreatment arrangement (100) comprises a reactor vessel (101) having an upstream inlet (102) for receiving biomass and a downstream outlet for discharging biomass (103). The pretreatment arrangement (104) further comprises a sluice vessel (104). The present disclosure also relates to a method (200) for pretreating lignocellulosic biomass.
Patent CA-3164333-A1 (CA)
Title: Heat- not- burn articles and related methods and systems
Inventor: KIBLER TYLER
IPC: A24B15/16
Filed: 2021-01-14
Abstract: Heat-not-burn articles are provided. In some embodiments, the heat-not-burn article may comprise: an inner core comprising at least one compressed rod of cannabis-based material; and an outer sheath comprising a sheet of plant-based material, the outer sheath receiving the inner core therein. The heat-not-burn articles may be heated without combustion to generate an inhalable aerosol and/or vapor, thereby reducing or eliminating undesirable byproducts typically associated with smoke. Also provided are related methods and systems for making a heat-not-burn article.
Patent CA-3172012-A1 (CA)
Inventor: NGUYEN MY T
IPC: G06N20/00
Filed: 2020-06-09
Abstract: Un système de surveillance d'insectes (ISM) et un système de commerce électronique sont décrits. L'ISM comprend une lumière pour attirer les insectes, une prise, un échappement, un conduit de circulation d'air entre les deux, un filet collecteur d'insectes dans le conduit, un ventilateur pour le conduit de circulation d'air et au moins une caméra. La lumière pour attirer les insectes et le ventilateur sont activés de sorte que les insectes soient attirés dans la prise et piégés dans le filet collecteur. Ledit filet est rotatif pour soit piéger ou libérer les insectes et un moyen de nettoyage est fourni pour nettoyer le filet d'insectes ou de débris. Des images d'insectes prises par les caméras sont analysées au moyen d'un algorithme d'apprentissage automatique pour reconnaître un type et un nombre d'insectes. Des recommandations sont présentées en fonction de l'analyse. L'ISM peut être connecté à des dispositifs électroniques client sur un réseau de communication. Les dispositifs électroniques ont une application de commerce électronique pour la vente de produits et de services.
Patent CA-3173818-A1 (CA)
Inventor: FILION MARIO
IPC: A61K35/17
Filed: 2022-04-27
Abstract: The present disclosure generally relates to a method of treating cancer by administration of autologous tumor infiltrating lymphocytes (TILs) isolated from a subject that has received prior treatment with an anti-cancer therapy that comprises an anti-clusterin antibody or antigen binding fragment thereof. The method of the present disclosure comprises administering the anti-cancer therapy to the subject, isolating TILs, and reinfusing TILs to the subject. The present disclosure also relates to the use of an anti-clusterin antibody or antigen binding fragment thereof in an in vitro or ex vivo method of generating tumor infiltrating lymphocytes (TILs).
Patent CA-3173998-A1 (CA)
Inventor: PAULSEN DANIELA
IPC: A61K45/06
Filed: 2021-05-10
Abstract: La présente invention concerne le traitement d'infections à coronavirus et la préparation de sujets pour une telle infection par l'administration d'un parapoxvirus. Ce traitement vise à aider le système immunitaire à lutter contre le virus et à prévenir et à soulager les symptômes de la maladie à coronavirus.
Patent CA-3174576-A1 (CA)
Title: Fil resistant au feu et a l'abrasion
Inventor: PATRICK GILBERT
IPC: D02G3/04
Filed: 2021-03-03
Abstract: L'invention concerne un procédé et un système de formation de fils résistant au feu et à l'abrasion. Le fil résistant au feu et à l'abrasion comprend un faisceau de fibres filé à partir d'un mélange de fibres ignifuges et de fibres non ignifuges. Le faisceau de fibres est enveloppé et intégré à un filament comprenant un matériau ignifuge (FR), et qui est introduit pendant le filage des fibres du faisceau de fibres de manière à être enroulé autour du faisceau de fibres et à contribuer à la liaison de celui-ci. Le filament FR est sélectionné parmi des matériaux résistant au feu/à la chaleur et résistant à l'abrasion, tandis que les fibres du faisceau de fibres peuvent être sélectionnées parmi des fibres ou des filaments naturels ou synthétiques ayant des propriétés supplémentaires souhaitées.
Patent CA-3175085-A1 (CA)
Inventor: SEACORD MICHAEL P
IPC: H05B3/56
Filed: 2021-03-16
Abstract: L'invention porte sur une couverture chauffante 11 qui comprend un élément chauffant auto-régulateur 16 qui permet un chauffage uniforme de la couverture chauffante 11.
Patent CA-3176812-A1 (CA)
Inventor: THANOS CHRISTOPHER D
IPC: C12N15/19
Filed: 2019-07-11
Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin- and/or pagP-. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd-, purl- and msbB-. The immunostimulatory bacteria, such as Salmonella species, are modified to encode immunostimulatory proteins that confer anti-tumor activity in the tumor microenvironment, and/or are modified so that the bacteria preferentially infect immune cells in the tumor microenvironment or tumor-resident immune cells and/or induce less cell death in immune cells than in other cells. Also provided are methods of inhibiting the growth or reducing the volume of a solid tumor by administering the immunostimulatory bacteria.
Patent CA-3177549-A1 (CA)
Title: Computer systems, computer-implemented methods, and computer devices for processing a transaction message
Inventor: MOUSSEAU GARY
IPC: G06Q40/00
Filed: 2020-04-30
Abstract: Systems, methods, and devices provide financial account services. The computer system provides financial services between one or more service requestor devices and one or more service provider devices. The computer system establishes links to one or more service provider devices by providing configuration to support the connection type, protocol and format of data exchanges with each of the service provider devices that have established links. The computer system authenticates each service provider device to establish trust for data exchanges. The computer system supports the reception of service requests from one or more service requestor devices. Then by using the configured link information, the computer system determines the type and format of service requests. The computer system transcodes the service request. The computer system permits the flow of service requests to two or more service provider devices when the configured link information are not similar.
Patent CA-3180133-A1 (CA)
Title: Peptides de nucleophosmine citrulines utilises en tant que vaccins anticancereux
Inventor: CHOUDHURY RUHUL
IPC: C07K14/47
Filed: 2021-04-20
Abstract: La présente invention concerne des peptides de nucléophosmine modifiés qui peuvent être utilisés dans l'immunothérapie anticancéreuse. Les peptides modifiés peuvent être utilisés en tant que vaccins ou en tant que cibles pour des récepteurs de lymphocytes T (TCR) et des thérapies de transfert de lymphocytes T adoptifs. De tels vaccins ou cibles peuvent être utilisés dans le traitement du cancer.
Patent CA-3180522-A1 (CA)
Title: Therapeutic methods for preventing tumor metastasis and tumor recurrence
Inventor: LISANTI MICHAEL P
IPC: C07D207/09
Filed: 2021-04-23
Abstract: Cancer stem cells are responsible for tumor recurrence, distant metastasis and drug-resistance, in the vast majority of cancer patients. There exists an urgent need to identify new mitochondrial inhibitor drugs that can target and eradicate CSCs, and companion diagnostics to identify candidates for mitochondrial inhibition therapy. In 3D mammospheres, 25 mitochondrial-related proteins were over 100-fold over-expressed in a large collection of transcriptional profiling data from ER(+) breast cancer patients. These 25 proteins may be used to derive short gene signatures to predict the likelihood of distant metastasis and tumor recurrence. For example, the 4-gene signature of ACLY, VDAC3, HADH2, and COX6B1 may be used for predicting the likelihood of distant metastasis, with a hazard ratio of 1.91-fold (P=2.2e-08). A pharmaceutically effective amount of a mitochondrial inhibitor may be administered to a candidate having elevated expression of the genes in a gene signature. Five example mitochondrial inhibitors showed preferential and selective inhibition of tumor cell metastasis, without causing significant toxicity. Mechanistically, all five mitochondrial inhibitors have been previously shown to induce ATP-depletion in cancer cells. Gene signatures composed of 6-9 large mitochondrial ribosomal proteins also show prognostic value in predicting distant metastasis, tumor recurrence, and Tamoxifen resistance, in both ER(+) and ER(-) breast cancer patients. The disclosed gene signatures may be used as companion diagnostics to assess which patients may benefit most from mitochondrial inhibition therapy.
Patent CA-3181582-A1 (CA)
Inventor: TAKEDA KAZUTOSHI
IPC: C09D7/63
Filed: 2021-06-17
Abstract: This coating composition for an electromagnetic steel sheet comprises: an epoxy resin; a phenol-based curing agent (A); and at least one amine-based curing agent (B) selected from among aromatic amine and dicyandiamide, wherein the content of the phenol-based curing agent (A) is 1-40 parts by mass with respect to 100 parts by mass of the epoxy resin, and the content of the amine-based curing agent (B) is 0.5-5 parts by mass with respect to 100 parts by mass of the epoxy resin.
Patent CA-3181696-A1 (CA)
Title: Methods and systems for analyzing image data
Inventor: BELITZ PAUL
IPC: G16B30/00
Filed: 2014-12-03
Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.
Patent CA-3181704-A1 (CA)
Title: A flexible package for food or beverage preparation having a rigid part
Inventor: PELLEGRINI STEPHANE
IPC: B65D85/804
Filed: 2021-06-24
Abstract: The present invention is directed to flexible or semi-flexible closed package (1) for containing an ingredient for preparing an edible product in a food or beverage preparation machine, said package comprising: (i) flexible or semi-flexible lateral walls (2) that form a flatten package body, and (ii) a cup-shaped bottom portion (3) adapted to the insertion of a fluid injection element of the machine, the package (1) being formed from a one-piece elongated primary flat blank sheet (5) made of flexible material, that is folded in a U-shape around its transversal symmetry axis (Lx), and sealed along its lateral (4) and upper (34) edges, wherein said cup-shaped bottom portion (3) is a hollow volume having a concave lower side (7) and convex lateral sides (8), and the profile curvature of said lower side (7) being identical to the profile curvature of each of said lateral sides (8).