baber/WOPTO huggingface dataset:
Patent NZ-539133-A (NZ)
Title: Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
Inventor: MARTINEZ ALEXA L
IPC: A61K47/48
Filed: 2003-09-25
Abstract: Provided are conjugates of a variety of bioactive components, especially proteins covalently attached to linear or branched polyalkylene glycol, wherein the polyalkylene glycol does not comprise an alkoxyl group at any terminus and said polyalkylene glycol is attached to a single bioactive component at a single site on the polyalkylene glycol. Also provided are methods of manufacture of the conjugates and uses of the conjugates in the manufacture of medicaments.
Patent NZ-541719-A (NZ)
Title: Beverage preservation and distribution can, also usable for the extemporaneous preparation of beverages by extraction and/or infusion
Inventor: BRIZIO ADRIANA
IPC: A47J31/54
Filed: 2004-02-11
Abstract: The beverage can presents immediately below the lid a first chamber (38) not initially containing beverages ready for use, but intended to receive the final beverage, said first chamber being separated by a sealed baffle (14) from a second chamber (16) which already contains, a drinkable liquid (18); said sealed baffle presenting a housing (20) constructed to receive a filtering device (24) provided with a tube (22) intended to dip into the interior of the chamber (16) containing the liquid (18). Means are provided to enable the consumer to dispose the filtering device (24) in the utilization condition in which communication is established between the two chambers (38 and 16) via said filtering device (24) such that, when the can is subjected to the action of a heat source, the liquid contained in the lower chamber (16) is transferred into the first chamber (38) by passing through said substance (28), to give rise to the formation of said beverage.
Patent NZ-542961-A (NZ)
Title: Grading apparatus
Inventor: DRABSCH BRUCE STANLEY
Filed: 2005-10-12
Abstract: An apparatus for grading items according to their size includes a transport arrangement arranged to move through a transport zone. The transport arrangement includes a number of parallel transport members, with adjacent members being connected to links by a pivot or an arcuate slot. Camming members are configured to pivot the links and adjust the spacing between the transport members in a grading zone.
Patent NZ-543726-A (NZ)
Title: Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity
Inventor: BABUSH JOHN
IPC: A61K31/557
Filed: 2004-05-21
Abstract: Disclosed are hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. Also disclosed are pharmaceutical compositions comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound.
Patent NZ-546094-A (NZ)
Title: Dual fuel boiler with backflow-preventing valve arrangement
Inventor: HALLIT RAYMOND
Filed: 2006-03-24
Abstract: A dual fuel boiler 10 has fuel delivery apparatus 18 coupled to its burner section 12 through a pressure regulator 36, 38 and operative to deliver to the burner section 12 from sources thereof, a selectively variable one of the first fuel 20 at a pressure greater than the pressure regulation setting of the pressure regulator 36, and a second fuel 22 at a pressure less than the pressure regulation setting, the second fuel 22 having a Wobbe index greater than that of the first fuel 20. The first fuel 20 is flowed back to the burner section 12 via a branch supply line 24 in which first 42 and second 44 electromechanical two positions, two-way, two-position valves are installed in series in opposite normal flow orientations to thereby prevent backflow of the second fuel 22 into the source of the first fuel 20.
Patent NZ-552271-A (NZ)
Title: Plant polynucleotide promoter sequence in the 4CL3 promoter from lolium, festuca and arabidopsis
Inventor: ELTON CLARE K
IPC: C12Q1/68
Filed: 2005-06-14
Abstract: Discloses isolated plant polynucleotide promoter sequences from Festuca arundinacea which comprise a sequence in the 4CL3 promoter selected from the group consisting of: (a) SEQ ID NO: 5 and 6. (b) complements of the sequence recited in SEQ ID NO: 5 and 6. (c) reverse complements of the sequence recited in SEQ ID NO: 5 and 6. (d) reverse sequences of the sequences recited in SEQ ID NO: 5 and 6. Also disclosed are methods for using such constructs in modulating the transcription of DNA sequences of interest, together with transgenic plants comprising such polynucleotides.
Patent NZ-552429-A (NZ)
Title: Inhibitors based on fusion, HR1 and HR2 sequences in bacterial adhesin
Inventor: MASIGNANI VEGA
IPC: C07K14/22
Filed: 2005-07-06
Abstract: Provided is an isolated or recombinant oligopeptide that can bind to the heptad repeat sequence(s) HRI and/or HR2 of the NadA adhesin on the surface of a meningococcus, thereby inhibiting the ability of the meningococcus either to infect a host organism or to spread an existing infection, wherein the oligopeptide consists of no more than 50 amino acids and comprises a specified amino acid sequence. Further provided are corresponding nucleic acids encoding the oligopeptide and methods of producing the oligopeptides.
Patent NZ-554552-A (NZ)
Title: Combinations comprising epothilones and protein tyrosine kinase inhibitors and pharmaceutical uses thereof
Inventor: HUANG JERRY MIN-JIAN
IPC: A61K31/426
Filed: 2005-11-28
Abstract: Disclosed is a combination comprising an epothilone derivative of general formula (I'), the protein kinase inhibitor {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-(1-[phenyl-ethyl)-amine and optionally a rapamycin derivative. Also disclosed is the use of the above combination for the preparation of a medicament for the treatment of a proliferative disease.
Patent NZ-555380-A (NZ)
Title: Pharmaceutical compositions based on tachykinin antagonists, including nepadutant, for pediatric colic
Inventor: ALEOTTI ALBERTO
Filed: 2005-10-26
Abstract: Disclosed is the use of a tachykinin antagonist for preparing pharmaceutical formulations for paediatric use for treating infantile colics, wherein said formulations are in a suitable form for oral administration, and wherein the tachykinin antagonist is a NK2 antagonist chosen from: cyclo((Asn(beta-D-2-deoxy-2-acetamido-Glc)-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta)), (nepadutant); cyclo((Asn(beta-D-galactopyranosyl)-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta)); cyclo((Asn(4-O-(alpha -DGlc)-beta-D-Glc)-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta)); cyclo((Dap(lactobionyl)-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta)).
Patent NZ-568359-A (NZ)
Title: Method for storing the position of a parked vehicle and navigation device arranged for that
Inventor: GEELEN PIETER ANDREAS
IPC: G01C21/06
Filed: 2007-01-12
Abstract: A navigation device comprises a processor unit, a memory device, and a positioning device. The processor unit is arranged to communicate with the memory device and the positioning device. The navigation device is arranged to detect parking of a vehicle by analysing positional data as measured by the positioning device, and, when parking is detected, determine information regarding the position of the parked vehicle using the positioning device, and store the information regarding the position of the parked vehicle in the memory device. The navigation device analyses the positional data as measured by the positioning device to detect parking of a vehicle by comparing the positional data with map data stored in the memory device.
Patent NZ-569036-A (NZ)
Title: Medicament dispenser for inhalation of powder with only part of the airflow drawn in directed to the blister pocket
Inventor: DAVIES MICHAEL BIRSHA
IPC: A61M15/00
Filed: 2006-12-11
Abstract: There is provided a medicament dispenser device for the delivery of medicament powder from an open blister pocket of at least one blister pack. The dispenser device comprises a housing having an air inlet (470); enclosed by the housing, a dispensing mechanism for the dispensing of medicament powder from an open blister pocket; and associated with the dispensing mechanism and in communication with the air inlet, a manifold (450). The manifold comprises a body, the body defining a chimney (452) having a chimney inlet (453) and a chimney exit (454b) for directing airflow (483) from said chimney inlet to said chimney exit; the body further defining a chamber having a chamber inlet (473b) and a chamber exit (474), wherein the chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof. In use, the airflow is drawn into the chimney of the manifold solely through the air inlet provided to the housing.
Patent NZ-570519-A (NZ)
Title: Garment for hospital patients, infirm or elderly people
Inventor: KEENAN SALLY
Filed: 2008-08-14
Abstract: A garment particularly suitable for use by a person with restricted upper limb and joint movement is disclosed. A front panel (102) of the garment has a shoulder edge (104, 106, 108, 110), and first (114) and second (112) side edges. First (116) and second (126) closure panels each have shoulder edges attached to the front panel shoulder edge near the first and second side edges respectively. Each closure panel has an unattached portion of the shoulder edge that forms a wrap-around portion. A fabric guide receives the free end of the first closure panel. Preferably the guide is a slit formed by an unattached area in the junction between the attached portion of the second closure panel and the front panel.
Patent NZ-573643-A (NZ)
Title: CYCLOALKANOPYRROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS which are useful in the treatment of neurodegenerative diseases
Inventor: WELLS GREGORY J
IPC: A61P15/00
Filed: 2007-06-19
Abstract: Disclosed are inhibitors of PARP, VEGFR2 and MLK3 having formula IIIa, where R2 is methyl substituted with lower alkoxy, and the remaining substituents are as defined in the specification. The compounds are useful in the treatment of neurodegenerative diseases such as Parkinson's, Huntington's and Alzheimer's disease, traumatic central nervous system injuries or preventing neuronal degradation associated with traumatic central nervous system injuries, cerebral ischemia, cardiac ischemia, inflammation, endotoxic shock, diabetes, cellular proliferative disorders related to solid tumors, diabetic retinopathy, intraocular neovascular syndromes, macular degeneration, rheumatoid arthritis, psoriasis, endometriosis and cancer.
Patent NZ-580801-A (NZ)
Title: Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
Inventor: YET LARRY
IPC: A61K31/5513
Filed: 2008-05-08
Abstract: Disclosed are 1-aryl-4-alkyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepines as represented by the general formula I(A-D), wherein: X represents a phenyl, benzo[1,3]dioxolyl, or naphthyl each optionally substituted from 1 to 3 times with halogen, -S(O)2R14, CN, or alkyl which may be optionally substituted with R10; R1 is alkyl; R2, R3, R5, R6, R7 and R8 are each hydrogen; R4 is halogen, NR12R13 or else R4 is piperazinyl, phenyl, pyridyl, 2-oxo-pyridin-1-yl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, pyrazolyl, [1,2,4]triazolo[4,3-a]pyridinyl or [1,2,4]triazolo[1,5-a]pyridinyl, optionally substituted from 1 to 4 times R9; R9 is independently selected at each occurrence from NR12R13, S(O)2R14, C(O)R15 or alkyl which may be optionally substituted with R10; R10 is halogen; R12 and R13 are each independently H or a 5 or 6-membered monocyclic heterocycle; R14 is alkyl; R15is NR12R13; or a pharmaceutically acceptable salt thereof. Representative compounds include 7 -fluoro-4-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[e ][1,4]diazepine, 7-fluoro-1-(3-fluorophenyl)-4-methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine, 1-(benzo[d][1,3]dioxol-5-yl)-4-methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine and 7-(4-(ethylsulfonyl)piperazin-1-yl)-4-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine. Further disclosed is a pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound as defined above, for treating a disorder selected from pain, attention deficit hyperactivity disorder (ADHD), cognition impairment, anxiety disorders, panic disorder, bipolar disorder, manic depression, obsessive compulsive disorder (OCD), posttraumatic stress disorder (PTSD), acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder (PMDD), social anxiety disorder (SAD), major depressive disorder (MDD), postnatal depression, dysthymia, depression associated with Alzheimer's disease, Parkinson's disease, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, analgesia, substance abuse disorders, chemical dependencies, drug addiction, neurodegenerative diseases, Parkinson's disease, sleep related eating disorder, stress urinary incontinence (SUI), migraine, diabetic neuropathy, fibromyalgia syndrome (FS), chronic fatigue syndrome (CFS), sexual dysfunction, premature ejaculation, male impotence, and thermoregulatory disorders.
Patent NZ-590460-A (NZ)
Title: Process for recharging electric vehicles in geographically distributed recharging stations
Inventor: GUNER REFI-TUGRUL
IPC: G07F15/00
Filed: 2011-01-12
Abstract: Process for recharging an electric vehicle in a recharging station of a network of geographically distributed recharging stations is disclosed. The availability of a recharging station to a control centre of the network is communicated and a recharge request from an onboard unit of the electric vehicle via communication devices of a road toll system to the control centre is transmitted. An onboard unit requesting recharging and an available recharging station are assigned to one another in the control centre. The onboard unit of the assigned recharging station via the communication devices of the road toll system is notified and the recharging station of the assigned onboard unit is notified. The recharging station to recharge the electric vehicle is activated when the assigned onboard unit is detected therein. The recharging process in the recharging station is monitored and an image of the vehicle is recorded in the recharging station by means of a camera in the event of an interruption, interference or deviation in the recharging process from a given course.
Patent NZ-602040-A (NZ)
Title: Anti-lrp6 antibodies
Inventor: HANNOUSH RAMI
IPC: A61K45/00
Filed: 2011-03-23
Abstract: Discloses a bispecific antibody that binds two different regions of low density lipoprotein receptor-related protein 6 (LRP6), wherein the antibody comprises a first VH domain comprising: HVR-H1 of YYYIS; HVR-H2 of EISPYSGSTYYADSVKG; HVR-H3 of RARPPIRLHPRGSV; a first VL domain comprising: HVR-L1 of RASQDVSTAVA; HVR-L2 of SASFLYS; HVR-L3 of QQSYTTPPT; a second VH domain comprising: HVR-H1 of NSYIH; HVR-H2 of WITPYGGYTNYADSVKG; HVR-H3 of GSGHVNAVKNYGYV; and a second VL domain comprising: HVR-L1 of RASQDVSTAVA; HVR-L2 of SASFLYS; and HVR-L3 of QQSYTTPPT. Further discloses related nucleic acids, immunoconjugates and therapeutic uses.
Patent NZ-603584-A (NZ)
Title: Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
Inventor: CURRIE MARTIN JAMES
IPC: C07D261/04
Filed: 2011-05-19
Abstract: Disclosed is a crystalline polymorph of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide (afoxolaner) designated as Form B characterized by a powder X-ray diffraction pattern having at least the 2θ reflection positions of 17.433, 18.586, 20.207, 20.791, 21.41, 22.112, 23.182, 24.567 and 27.844, and which may be obtainable by recrystallisation of the compound from methanol/water. Also disclosed is a composition comprising the polymorph Form B of afoxolaner as defined above and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, said composition optionally further comprising at least one additional biologically active compound or agent. Also disclosed is a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its non-human environment with a biologically effective amount of the polymorph Form B of afoxolaner as defined above.
Patent NZ-621215-A (NZ)
Title: Treatment of multiple sclerosis with combination of laquinimod and interferon-beta
Inventor: TARCIC NORA
IPC: A61P37/02
Filed: 2012-07-27
Abstract: This disclosure provides a method of treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the patient laquinimod as an add-on therapy to or in combination with interferon-β. This invention also provides a package and a pharmaceutical composition comprising laquinimod and interferon-β for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This disclosure also provides laquinimod for use as an add-on therapy or in combination with interferon-β in treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This disclosure further provides use of laquinimod and interferon-β in the preparation of a combination for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome.
Patent NZ-707821-A (NZ)
Title: Ergonomic and adjustable respiratory mask assembly
Inventor: MOORE RACHAEL
IPC: A61M16/06
Filed: 2003-04-17
Abstract: A patient interface including a frame (20), a cushion, gas washout holes, headgear and an elbow assembly having a pair of diametrically opposed snap-fit connections (181) releasably snap-fittable to the frame with an audible click signalling that the elbow assembly has been securely attached to the frame. The elbow assembly includes a rotatable elbow.
Patent NZ-710322-A (NZ)
Title: A novel formulation of metaxalone
Inventor: NORRET MARCK
IPC: A61P21/02
Filed: 2010-04-23
Abstract: The present disclosure relates to methods for producing particles of metaxalone using dry milling processes to produce particles of the biologically active material dispersed in an at least partially milled grinding matrix as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments. wherein the milled metaxalone has a dissolution profile, when tested using USP Apparatus II (paddles) set to rotation speed of 100 RPM in 1000 mL of 0.01 M HCl at pH 2 at 37±0.5°C, of no less than 15% dissolution, by weight, at 60 minutes, when measured under sink conditions.
Patent NZ-713910-A (NZ)
Title: Optical joint closure
Inventor: KERRY MATT
IPC: G02B6/44
Filed: 2013-05-08
Abstract: In order to reduce the overall space of an optical joint closure, simplify the installation operations for the installers and saving space e.g. in a manhole, an optical joint closure (1) comprises a casing (2) defining a cavity and a closure cap (3), and a plurality of splice trays (6) housed within the cavity, wherein the joint closure (1) comprises a bracket (10) extending through and contained within the contour of the closure cap (3). The bracket (10) has a first protruding portion (12) that protrudes from the closure cap (3) at a side opposite a side facing the casing (2). The bracket (10) also has a second protruding portion (13) that protrudes from the closure cap (3) at the side facing the casing and within the casing (2). Because the bracket has a portion that extends to protrude from the side of the closure cap facing the casing and protrudes within the casing, it has the advantage that the casing and the components housed therein are borne more efficiently because they are not cantilever with respect to the closure cap.
Patent NZ-719065-A (NZ)
Title: All-terrain vehicle and suspension for an all-terrain vehicle
Inventor: GARAGASHYAN ALEKSEY
IPC: B60G21/06
Filed: 2015-08-12
Abstract: The invention relates to vehicles for off-road driving, both on land and on water, which can be used for construction of vehicles with good cross-country ability, (all-terrain vehicles). Existing all-terrain vehicles have suspension systems which suffer significant disadvantages including poor reliability under complex terrain conditions. The claimed all-terrain vehicle comprises an airline which is connected to all of the wheel tyres simultaneously and is coupled to a system for inflating the tyres. A suspension of an all-terrain vehicle comprises a wheel suspension system connected with the wheel tyres, a fluid power drive, and a tyre inflation system, a wheel suspension system configured as an air line formed by hollow tubes welded together to make a frame formed by side members and cross bars or it is configured outside a frame to form a closed circuit connected with each tyre by means of pipelines with valve members, whereas as a fluid power drive and a tyre inflation system the claimed invention provides an engine exhaust system equipped with a damper and connected with an air line through a pipeline with a valve member.
Patent NZ-740193-A (NZ)
Title: A line strainer
Inventor: Robert andrew wade
IPC: B21F9/00
Filed: 2016-07-29
Abstract: A line strainer for use in an electric fence system is described. The line strainer includes a unitary body made of electrically non-conductive material, having two opposing arms, a spool mounting element for rotatably mounting an electrically conductive spool having at least one toothed flange between the arms of the body, wherein the spool is configured to have a first line secured to it. The line strainer further includes a line bearing support member with a curved support surface about which a second line is to be passed and tensioned. A releasable pawl is attached to the unitary body and configured to engage with the at least one toothed flange to restrict rotation of the spool in one direction when the spool is rotatably mounted to the spool mounting element. The curved support surface of the line bearing support member centralises the second line so the force experienced from the second line is distributed evenly between the arms of the strainer, therefore reducing the formation of cracks and early failure from localised stress.
Patent NZ-748776-A (NZ)
Title: Tagmentation using immobilized transposomes with linkers
Inventor: DESANTIS GRACE
IPC: C12Q1/6806
Filed: 2018-02-20
Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
Patent NZ-755447-A (NZ)
Title: N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer
Inventor: BEN NERIAH YINON
IPC: C07D403/04
Filed: 2018-01-30
Abstract: The present invention provides pyrazole derivatives of Formula (I), and in particular N1-(4-(5-(cyclopropylmethyl)-1-methyl-lH-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as casein kinase 1 (CK1) and/or interleukin 1 receptor associated kinase 1 (IRAKI) inhibitors for treating cancer, inflammatory and immune related disorders.