baber/WOPTO huggingface dataset:
Patent CO-7180201-A2 (CO)
Title: Inhibidores de neprilisina
Inventor: FLEURY MELISSA
IPC: C07D405/12
Filed: 2015-01-27
Abstract: Compuestos de la fórmula Donde X, R, R, Ry Rson como se definen en la Descripción, o una sal farmacéuticamente aceptables de los mismos. Estos compuestos son prodrogas de compuestos que tienen actividad inhibidora de neprilisina. En otro aspecto, la invención se relaciona con composiciones farmacéuticas que comprenden estos compuestos; métodos de uso de estos compuestos; y procesos e intermediarios para la preparación de los compuestos. a b 2 7
Patent CO-7400884-A2 (CO)
Title: Moléculas de enlace a il-18
Inventor: BARDROFF MICHAEL OTTO
IPC: G01N33/50
Filed: 2015-03-06
Abstract: La IL-18 participa en la inmunidad tanto innata como adquirida. La bioactividad de IL-18 es negativamente regulada por la proteína de enlace a IL-18 (IL18BP), un inhibidor de origen natural y altamente específico. Esta proteína soluble forma un complejo con la IL-18 libre que impide su interacción con el receptor de IL-18, neutralizando e inhibiendo, por consiguiente, su actividad biológica. La presente invención da a conocer moléculas de enlace, en particular anticuerpos o fragmentos de los mismos, que se enlazan a la IL-18 y no se enlazan a la IL-18 enlazada a IL-18BP (complejo de IL-18/IL-18BP). Aparte de su función fisiológica, se ha demostrado que la IL-18 media una variedad de enfermedades autoinmunes e inflamatorias. Las moléculas de enlace de la invención se pueden utilizar como moléculas terapéuticas para el tratamiento de enfermedades autoinmunes e inflamatorias relacionadas con la IL-18, o como herramientas de diagnóstico para caracterizar, detectar y/o medir la IL-18 no enlazada a IL-18BP como el componente de la reserva total de IL-18.
Patent EP-1028188-A2 (EP)
Inventor: BERSCHNEIDER HORST
IPC: D06F58/36
Filed: 2000-01-28
Abstract: The appliances (1,2) located on top of each other, are connected through interfaces (3,4).  The appliances (1,2) are program-controlled units which execute successive processes on the same objects, eg. a washing machine (1) and a dryer (2).
Patent EP-1030432-A2 (EP)
Inventor: MARX PETER
IPC: H02K5/12
Filed: 2000-02-04
Abstract: The magnetic poles (14.15) of the motor stator (6) are held in position by spring spacers (18,19). These have a surface profile (20) facing the rotor (7) shaped so that the gap (21) between rotor and stator has a uniform width over its whole circumference. This provides a smooth path for the fuel as it flows through the motor
Patent EP-1041257-A2 (EP)
Inventor: KANDA MUTSUMI
IPC: F02F1/24
Filed: 2000-03-29
Abstract: A direct fuel injection-type spark-ignition internal
combustion engine is disclosed. The engine comprises a
spark plug, a fuel injection valve and a cavity formed on
the top surface of the piston. The cavity has a bottom
wall, a spark plug side wall and a fuel injection valve
side wall. The fuel injection valve injects fuel toward
the bottom wall of the cavity in stratified charge
combustion. The fuel mainly proceeds toward the spark
plug side wall of the cavity along the bottom wall, is
deflected by the spark plug side wall and is led to the
vicinity of the spark plug. In the engine, the spark
plug side wall of the cavity is provided with a
deflecting portion inclined toward the inside of the
cavity. A first part of the deflecting portion provided
on both sides of the spark plug side wall functions to
lead the fuel to the vicinity of the spark plug. A
second part of the deflecting portion on the central
portion of the spark plug side wall functions to lead the
fuel to a region neighboring the side of the fuel
injection valve from the vicinity of the spark plug.
Patent EP-1054009-A2 (EP)
Inventor: GEISSLER HOLGER DR
IPC: C07C67/307
Filed: 2000-04-27
Abstract: Production of 3-isochromanone compounds (I) comprises cyclizing 2-chloromethyl-phenylacetic acid compounds (II) at 100-250 degrees C optionally in the presence of an ionic halide or organic solvent while separating hydrogen chloride (HCl). Production of 3-isochromanone compounds of formula (I) comprises cyclizing 2-chloromethyl-phenylacetic acid compounds of formula (II) at 100-250 degrees C optionally in the presence of an ionic halide or organic solvent while separating HCl: R<1>-R<4> = H, F, CN, CF3, 1-18C alkyl, alkoxy or acyloxy, 6-18C aryloxy, aryl or heteroaryl containing 1-3 heteroatoms selected from O, N and S, or two or more of R<1>-R<4> can be linked to form at least one 5-18C alicyclic or aromatic ring.
Patent EP-1071274-A2 (EP)
Inventor: KAMADA TAKASHI
IPC: G06T1/00
Filed: 2000-07-18
Abstract: An image reading apparatus, comprises an image reader to read
images of a document; a rotation processor to conduct a
rotation processing for image data obtained through reading
by the image reader in accordance with inclination of the
document; a memory in which image data subjected to rotation
processing by the rotation processor are stored; and an
external inputting device to input arbitrary rotation angles.
When the rotation angles are inputted from the external
inputting device, the image data obtained through reading by
the image reader are subjected to the rotation processing in
accordance with the inputted rotation angle and are stored in
the memory.
Patent EP-1087213-A2 (EP)
Inventor: KANKE ATSUSHI
IPC: G01F1/684
Filed: 2000-09-04
Abstract: The invention relates to an air flow meter for an
internal combustion engine having an exothermic resistor film
(11, 211) provided on a thin portion formed on a silicon
substrate and a control circuit (220) for controlling a
voltage to be applied to the resistor film (11, 211) or a
current to be supplied. The resistor film (11, 211) is
arranged in a suction pipe of the internal combustion engine
and heat is emitted to an air through the resistor film (11,
211). In the case where a liquid droplet is deposited onto
the resistor film (11, 211), the control circuit (220)
controls the applied voltage to a value smaller than a
voltage which is applied to the resistor film (11, 211) at
the time of measuring a maximum specified measuring range or
controls the supply current to a value smaller than a current
flowing in the resistor film (11, 211) at the time of
measuring the maximum specified range.
Patent EP-1090801-A2 (EP)
Inventor: MANNIGEL DIETER
IPC: B60W30/18
Filed: 2000-09-18
Abstract: The method is carried out so that with a gear change operation, desired values esp. the aimed for gear position and an engine aimed for rpm during the coupling of the clutch are determined. So that an output signal, esp. the model rpm is initiated by the determined engine aimed for rpm.
Patent EP-1097733-A2 (EP)
Title: Skateboard
Inventor: ZWINGER CHRISTIAN
IPC: A63C17/01
Filed: 2000-10-31
Abstract: A skateboard with improved handling has a tubular support frame with a large front wheel (3) mounted between front forks and steerable about a castor angle. The rear of the board has either a large single rear wheel held between rear forks or has two rear wheels. The front wheel can be a double design and the rear wheels are braked by a foot operated brake. The support platform is low slung and set below the level of the tops of the wheels.
Patent EP-1111499-A2 (EP)
Inventor: BROGHAMMER BERNHARD
IPC: H04N19/61
Filed: 2000-11-30
Abstract: An input (9) has an interface controller (IC) (10) to edit data fed in via the input. A bit stream decoder (BSD) (11) connects to the IC to decompress compressed graphics data received via the IC and to convert it into pixel graphics data. A graphics controller (GC) (12) connects to the IC to convert vector graphics commands received via the IC into pixel graphics data. A graphics chip (13) connects to the IC, the GC and the BSD to edit pixel graphics data received from these via connection lines (4) and to feed it to a display screen (3).
Patent EP-1060910-A2 (EP)
Inventor: NELSON DAVID J C
IPC: B42F5/04
Filed: 2000-06-07
Abstract: A jacket for one or more printed sheets, such as photographic
prints, has a holder having at least one pocket. The pocket defines a space for the
printed sheet. The holder has a transparent ink receptive layer exterior to the
space. The ink receptive layer can have a deposit of invisible ink that is an
encodement of information that, preferably, relates to the respective printed sheet.
Two or more such jackets can be bound together to provide an album.
Patent EP-1024249-A2 (EP)
Inventor: RINGGENBERG PAUL D
IPC: E21B34/10
Filed: 2000-01-24
Abstract: A downhole tool (100) for selectively providing fluid communication between the
interior and the exterior of the tool (100) is disclosed. The tool (100) comprises a
housing (102), a safety mandrel (130) slidably received within the housing (102) and
an operating mandrel (114) slidably received within the housing (102). The safety
mandrel (130) operates between a first position and a second position relative to the
housing (102) in response to pressure being applied to the exterior of the housing
(102). The operating mandrel (114) operates from a noncirculating position to a
circulating position in response to pressure being applied to the interior of the housing
(102) once the safety mandrel (130) has operated to its second position.
Patent EP-1051986-A2 (EP)
Inventor: COBB ANTHONY RICHARD
IPC: A61M5/145
Filed: 2000-04-19
Abstract: A syringe pump has a drive mechanism 7 for moving the plunger 35 of a syringe 3
along a barrel 30. Ears 33 at the rear of the barrel 30 engage against a wall 32 on the pump
and an L shape clamp arm 44 is urged against the ears by a spring 49. The clamp arm 44 is
mounted about an axis at right-angles to the syringe 3 and is articulated at a point 45 along its
length. A lever 52 having a flag 53 at one end is pivoted about a horizontal axis by movement
of the arm and moves relative to an optical sensor 54 so that the output of the sensor indicates
whether the syringe 3 is correctly loaded in the pump. The clamp arm 44 is rotated away from
the barrel 30 by the drive mechanism during loading of the syringe 3.
Patent EP-1055909-A2 (EP)
Inventor: ONO YASUICHI
IPC: G01C19/5607
Filed: 2000-05-24
Abstract: A pair of electrodes (10a, 10b) are formed on the
front surface and the rear surface of each vibrator (10u,
10v, 10w) in a longitudinal direction, and dielectric
polarization is performed in the direction from the front
surface to the rear surface. When I/V converters
constituted by operational amplifiers are connected to
electrodes of the middle vibrator, the detection electrodes
can be grounded to a reference potential Vref through the
imaginary short circuits of the I/V converters, so that a
gyroscope can be vibrated without a conventional ground
electrode. Therefore, the number of electrodes of the
vibrators can be reduced, and an interval size between the
drive electrodes or between the detection electrodes can be
assured. For this reason, sufficient dielectric
polarization can be performed when a high voltage is
applied.
Patent EP-1060943-A2 (EP)
Title: Automatic temperature controlled seat for vehicles
Inventor: OEHRING CHRIS GEORGE
IPC: B60N2/56
Filed: 2000-06-05
Abstract: A method for automatically controlling the temperature
of a vehicle seat (14) based on a variety of factors,
including vehicle interior temperature, outside temperature,
sunload, and user set point. Each of these readings is sent
to a controller (30) where they are weighted by a formula to
arrive at a target temperature. Based on that target
temperature, a seat level is calculated and then transmitted
to a heated seat controller (48) to apply the appropriate
temperature to the vehicle seats (14). A system for
controlling the temperature of a vehicle seat is also
disclosed.
Patent EP-1075158-A2 (EP)
Inventor: SCHMIDL TIMOTHY M
IPC: H04B1/707
Filed: 2000-07-13
Abstract: A wireless communication system (10). The system
comprises transmitter circuitry (BST1) comprising circuitry
for transmitting a plurality of frames to a receiver in a
first cell (Cell 1). Each of the plurality of frames
comprises a bit group (22), and the bit group uniquely
distinguishes the first cell from a second cell (Cell 2)
adjacent the first cell. The transmitter circuitry further
comprises circuitry (54) for inserting a bit sequence into
the bit group. The bit sequence is selected from a
plurality of bit sequences (S 1 -S   K   ) such that successive
transmissions by the transmitter circuitry comprise a cycle
of successive ones of the plurality of bit sequences.
Patent EP-1081335-A2 (EP)
Inventor: MCMAHON MICHAEL E
IPC: F01D5/30
Filed: 2000-08-09
Abstract: A stator assembly comprises an inner shroud assembly formed
of a thermoplastic inner shroud 56 and a preformed
elastomeric rubstrip 58 e.g. silicone rubber. The rubstrip
58 is bonded to the thermoplastic shroud 58 by a bond layer
86. The bond layer may comprise an epoxy primer 96, a
silicone rubber primer 98 and a silicone rubber adhesive
102 (see FIG. 10). The method is generally applicable to
joining an elastomer, such as silicone rubber material, to
a thermoplastic substrate.
Patent EP-1091023-A2 (EP)
Inventor: SCHETTY III ROBERT A
IPC: C25D3/60
Filed: 2000-10-06
Abstract: Disclosed are electrolyte compositions for depositing tin-copper alloys
that are substantially free of lead. Also disclosed are methods of plating tin-copper
alloys that are substantially free of lead on substrates and uses for
such plated substrates.
Patent EP-1094611-A2 (EP)
Inventor: WHIKEHART WILLIAM J
IPC: H03M1/74
Filed: 2000-10-06
Abstract: A component selector assembly 10 which pseudo-randomly
energizes components 40-54 by use of received data 60.
Patent EP-1098272-A2 (EP)
Inventor: CHADWICK NEVILLE DALE
IPC: G07F17/32
Filed: 2000-11-06
Abstract: An entertainment machine having associated therewith an input means
adapted to allow a first identity, associated with a winning machine result,
and a second identity to be input, a control means adapted to control the
apparatus, a memory means adapted to store the identities and a pay-out
apparatus the control means being adapted to cause the apparatus to
require the second identity to be input on a subsequent occasion allowing
the identity of the player who entered the first identity to be confirmed
and when said first identity has been confirmed said machine being
adapted to enter a pay out mode wherein the pay out apparatus is adapted
to make an award from the machine. The machine is particularly suitable
for playing tournament games in which a prize is paid out a time period
after a player has performed his/her prize winning performance. 
     To be accompanied, when published, by Figure 1 of the drawings.
Patent EP-1104036-A2 (EP)
Inventor: TSUBOYAMA AKIRA
IPC: H01L51/50
Filed: 2000-11-28
Abstract: A liquid crystal device, suitably included in e.g., an
organic EL device, is formed of a pair of electrodes
(1,4), and a plurality of layers (2,3,7,8) disposed
between the electrodes and including at least one liquid
crystal layer (2). The liquid crystal layer (2)
comprises a liquid crystal composition having an
electronic carrier-transporting function and comprising
at least two compounds including at least one electron-donating
compound or electron-accepting compound having
a n-electron conjugated structure. As a result of doping
the liquid crystal layer (2) with the electron-donating
or electron-accepting compound, the current conduction
performance of the liquid crystal layer (2) is improved
presumably due to generation of free carriers therein,
whereby a functional device including the liquid crystal
device can be improved as a whole.
Patent EP-1043223-A2 (EP)
Inventor: MUNOZ SAIZ MANUEL
IPC: B64C9/24
Filed: 2000-03-30
Abstract: The enhanced aerodynamic profile of the invention consists of a
profile consisting of three sections: a front or leading edge of two sides
or plates forming an acute dihedral angle with the vertex facing forward,
a central section formed by two parallel sides or plates, and a rear
section or trailing edge formed by two sides or plates at an acute
dihedral angle with the vertex facing rearward, where the unions on the
lower or upper surfaces are suitably rounded, where the front section is
a fin or cone turning on an axis which divides it into two unequal parts,
the rear part being larger, said fin or cone has the lower surface of its
rear section inclined, adapting with another which is inclined in the
upper front part of the central section, said fin with positive leading
angles is automatically oriented with the direction of the slipstream.
Patent EP-1079196-A2 (EP)
Inventor: SARRIUGARTE ALDECOA JUAN CRUZ
IPC: F41C7/00
Filed: 2000-07-28
Abstract: Based on a trigger plate (1) equipped with means for mounting upon it the
firing mechanism proper, comprising the rocker (4) of the breech block, the
hammers (8), the hammer rocker (9), the spring (10), the top cap (11) for
the said spring, the trigger rocker (12) and the counterweight (13), it is
characterised in the fact that the said trigger plate (1) has at its forward end
a latch (14) which interlocks with the forward end of the housing recess in
the stock of the gun for the said firing mechanism, while at its posterior end
and substantially recessed it incorporates a locking catch (16), which can
be retracted against the tension of a spring (17), by acting on an external
button (23), a catch which can be engaged in a complementary housing in
the said recess in the stock of the gun, all such that the trigger plate (1)
and the firing mechanism as a whole associated therewith is engaged in
the recess in the stock of the gun by simple pressure and can be removed
without anything more than pressing the said button (23) which is protected
beneath a posterior extension (24) of the trigger guard (2) protecting the
trigger (3).
Patent EP-1166328-A2 (EP)
Inventor: ZIMMERMANN RALF
IPC: G01N21/64
Filed: 2000-02-23
Abstract: Die Erfindung betrifft einen Gaseinlass zur Erzeugung eines gerichteten und gekühlten Gasstrahls in einer Ionenquelle oder einer UV/Fluoreszenzmesszelle. Aufgabe der Erfindung ist es, den Gaseinlass so zu modifizieren, dass bei einfachem Aufbau eine effektive Kühlung eines kontinuierlichen Gasstrahls bei relativ geringem Einlassvolumenstrom ermöglicht wird. Gelöst wird diese Aufgabe durch eine Kapillare, die gasdicht von aussen in das evakuierte Innere der Anordnung der Ionenquelle oder der UV/Fluoreszenzmesszelle führt und deren im Vakuum befindliches Ende eine Düse zur adiabatischen Kühlung des Gases aufweist, wobei die lichte Weite der Düsenöffnung höchstens 40 % des Kapillareninnendurchmessers beträgt.
Patent EP-1178999-A2 (EP)
Inventor: WENGEL JESPER
IPC: C12Q1/68
Filed: 2000-05-04
Abstract: Selon l'invention, des analogues de nucléoside, dans lesquels un pont 2'-4' verrouille la conformation du nucléoside, ont été synthétisés par stéréochimie inversée aux niveaux C-3' et C-4' de manière à former le nucléoside LNA à structure L-ribo. La synthèse du nucléoside L-ribo-LNA est applicable à toutes les nucléobases, telles que la thymine, l'adénine, la cytosine, la guanine et l'uracile. Ces acides nucléiques verrouillés (LNA) à structure L-ribo ont été utilisés dans la synthèse de nucléotides 2'-O-4'-C-méthylène- alpha -L-ribofuranosyle et d'oligonucléotides comprenant des nucléosides L-ribo-LNA. Les procédés de ciblage d'acides nucléiques complémentaires sont nettement améliorés grâce à l'utilisation de ces oligonucléotides modifiés L-ribo-LNA, étant donné leur grande affinité avec lesdits acides nucléiques complémentaires.
Patent EP-1194629-A2 (EP)
Inventor: IRVIN ANN MARGARET
IPC: B05C17/10
Filed: 2000-07-11
Abstract: The present invention relates to an applicator for a fabric treatment composition and its application. More specifically the invention relates to a versatile, effective convenient to apply fabric treatment applicator. Claimed and described is an applicator for a fabric treatment composition, which does not require rinsing, comprising an application device, which induces a certain frictional stress upon fabric.
Patent EP-1246648-A2 (EP)
Inventor: ROEDER BEATE
IPC: A61K31/409
Filed: 2000-07-28
Abstract: La présente invention concerne une technique destinée à des traitements par thérapie photodynamique (TPD) qui consiste à appliquer des complexes photosensibilisants dendrimères de façon à apporter de multiples groupes fonctionnels photosensibilisants sur un site de traitement. Des photosensibilisants sont couplés par covalence aux emplacements périphériques de liaison de dendrimères pour être séparés dans un ou plusieurs cycles successifs. Les photosensibilisants utilisés sont des tétrapyrroles. Dans un mode de réalisation de l'invention le complexe est également lié à un anticorps ou à un fragment d'anticorps, ce qui aide à cibler le complexe sur un site de traitement recherché. Après application, les photosensibilisants sont libérés sur le site de traitement, à partir des complexes soit par un effet lumineux, soit par un effet chimique ou encore par un effet combiné lumineux/chimique. En général les photosensibilisants dégagent leur activité photodynamique complète sous forme de molécules libres après avoir été libérés du complexe. On peut lier plus d'un type de photosensibilisant à ces complexes. On peut effectuer la libération et/ou l'activation en une seule étape ou par des étapes répétées.
Patent EP-1211997-A2 (EP)
Inventor: NEUBERGER WOLFGANG
IPC: A61B18/22
Filed: 2000-08-10
Abstract: L'invention concerne un dispositif servant à la fois à inciser une zone et à cautériser un tissu souhaité. Ce dispositif permet d'intégrer une énergie laser par un moyen quelconque dans un scalpel mécanique de manière que la zone incisée soit également cautérisée. Par exemple, une source laser est couplée par un moyen quelconque à une lame optiquement transparente, telle qu'un diamant de coupe. Ce diamant de coupe est enveloppé de façon que le rayonnement ne sorte qu'au niveau des zones souhaitées. Dans un autre exemple, des fibres optiques sont intégrées à un scalpel à lame tranchante avec un organe permettant d'effectuer un couplage avec une source de rayonnement appropriée.
Patent EP-1228199-A2 (EP)
Title: Method for directed packaging of molecular substances in protein shells
Inventor: BOEHM GERALD
IPC: C12N15/09
Filed: 2000-11-03
Abstract: The invention relates to a method for packaging molecular substances in protein shells, comprising the following steps: binding a protein shell fragment, via a first region to a matrix; bringing the protein shell fragment bound to the matrix into contact with the molecular substance, in order to bind the molecular substance to a second region of the protein shell fragment; separating the protein shell fragment with the bonded molecular substance, or the part thereof which contains the bonded molecular substance, from the matrix and assembling the separated protein shell fragments, or the part thereof which contains the bonded molecular substance, with other protein shell fragments to form a protein shell, whereby the separation and assembly can be carried out in any order.
Patent EP-1266318-A2 (EP)
Inventor: JOHNSON CHRISTOPHER D
IPC: G06Q40/00
Filed: 2000-12-20
Abstract: A method (32) of valuation of large groups of assets by selecting a lowest variation assumption for asset valuation in order to limit risk includes the steps of evaluating assets by all known valuation methodologies which have merit for those particular assets, selecting the valuation methodology which is most accurate for the assets being evaluated and assigning values to the assets. Individual asset values are developed and listed in tables so that individual asset values can be taken from the tables and grouped in any desired manner. The assets are divided into categories by credit variable and then rated individually.