baber/WOPTO huggingface dataset:
Patent PL-2333159-T3 (PL)
Title: Crash barrier
Inventor: VOLKMANN VANESSA
IPC: E01F15/04
Filed: 2009-12-03
Abstract: The structure has a supporting element (116) arranged between a set of profiled posts (112) and a continuous guard-rail line (114). An intermediate element (120) is arranged between the supporting element and the guard-rail line and designed such that the guard-rail line runs at an inclination angle to a longitudinal axis (L) of the posts. The supporting element is designed asymmetrically for adaptation to the angle between the guard-rail line and the axis and comprises limbs (122, 124) that project from a fastening portion (118) in direction of the guard-rail line.
Patent PL-2172648-T3 (PL)
Title: Blade for a wind turbine rotor
Inventor: GRABAU PETER
IPC: F03D1/06
Filed: 2006-10-17
Abstract: A blade (1) for a rotor of a wind turbine having a substantially horizontal rotor shaft, said rotor comprising a hub, extends substantially radially from said rotor when mounted. The blade (1) has a chord plane (K) extending between the leading edge (5) and the trailing edge (6) of the blade (1). The blade (1) comprises a root area (2) closest to the hub, an airfoil area (4) furthest away from the hub and a transition area (3) between the root area (2) and the airfoil area (4), and comprises a single airfoil along substantially the entire airfoil area (4). The blade (1) comprises at least a first root segment (7) and a second root segment (8) along substantially the entire root area (2), said segments being arranged with a mutual distance, as seen transverse to the chord plane (K). At least one of the root segments (7, 8) has an airfoil profile.
Patent PL-2264156-T3 (PL)
Title: Phytases
Inventor: MIASNIKOV ANDREI
IPC: C12N15/55
Filed: 2005-10-17
Abstract: The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof.
Patent PL-2239909-T3 (PL)
Title: Apparatus for transmitting and receiving a signal and method of transmitting and receiving a signal
Inventor: KO WOO SUK
IPC: H04L27/26
Filed: 2008-12-11
Abstract: There is disclosed a method of receiving a broadcasting signal, the method comprising: receiving a broadcast signal including a frame and a first pilot, P1, symbol at a beginning part of the frame, wherein the frame includes a second pilot, P2, symbol having layer 1, L1, information being signaling information for data symbols of physical layer pipe, PLP, data in the frame, and wherein the L1 information includes an index of a current radio frequency channel within the frame; demapping the data symbols to PLP bits for conveying a service stream according to a symbol mapping method; and, decoding the PLP bits for forward error correction, FEC.
Patent PL-2369005-T3 (PL)
Title: Biological active proteins having increased in vivo and/or in vitro stability
Inventor: SKERRA ARNE
IPC: A61K38/17
Filed: 2008-06-20
Abstract: The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation whereby said random coil conformation mediates an increased in vivo and/or in vitro stability of said biologically active protein. Furthermore, nucleic acid molecules encoding the inventive biologically active proteins and vectors and cells comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions comprising the compounds of the invention as well as for specific uses of the biologically active proteins, nucleic acid molecules, vectors and cells of the invention.
Patent GR-3000652-T3 (GR)
Title: Electrical or electronic door lock, especially a mortise lock
Inventor: ABEND KLAUS DR-ING
IPC: E05B47/00
Filed: 1990-07-19
Abstract: 1. Electrically or electronically operated and/or controlled or driven door lock, in particular a mortise lock, for an electronic key (33) which is provided with a memory facility for key information, with a lock housing (1), a latch (3) which can be operated at least from the inside of the door by means of a handle, and which engages in a facer plate, a tongue (4) which can be locked-out of the facer plate, an electrically operable locking mechanism (51) for the tongue (4), a scanning facility (31) for the key information of the electronic key (33) and a control circuit (30) which is dependent on the locking mechanism (51) and controlled by means of the scanned key information, with gearing (58, 59) which is driven by the electro motor (29) and a detent pawl (17) which can be mechanically controlled by means of the tongue (4) and the gearing, which inhibits the tongue (4) both in the position which is completely enclosed inside the lock housing (1) as well as in the position which is completely excluded from the key housing (1), axially in order to relieve the electro motor (29) whereby the latch (3) and the tongue (4) can be operated by means of the electro motor (29) to travel into the housing (1) and the tongue (4) can be operated to travel out of the housing, and that the transmission ratio between the electro motor (29) and the latch (3) on the one hand and the electro motor (29) and the tongue (4) on the other hand can be changed during the locking-in and the locking-out travel of the latch (3) and the tongue (4).
Patent GR-3007412-T3 (GR)
IPC: B68G7/10
Filed: 1993-03-19
Abstract: A guide apparatus for the beading that is bordering for the connection of a front component and of a side stripe of a mattress sheath or cover or the like, by means of a beading machine, which comprises: a fixed structure with perimetral tracks (20) for a beading machine (22); a frame (7) for a template provided for the assembly of the cover components; cross-like guide means (1A-3A) for the displacements of said frame (7) parallel to itself with a limited inclination with respect to said tracks (20); as well as thrust means (24) that can be activated and disactivated according to the position reached by the beading machine along the tracks, in order to move, in a programmed fashion, the template close to particular zones of the track; and means for blocking the frame to the structure in correspondence of the curved trajectories of the beading machine, and to release the frame in time and set free the movements thereof during the beading of same curves.
Patent GR-3008294-T3 (GR)
IPC: C07B61/00
Filed: 1993-06-25
Abstract: A process for the preparation of cis-dihydronopol and its esters is described. Corresponding esters of (-)-nopol are hydrogenated stereoselectively by heterogeneous hydrogenation in the presence of a platinum or platinum oxide catalyst or of a ruthenium/carbon catalyst and the cis-dihydronopyl esters obtained are, if desired, converted into the corresponding alcohol.
Patent GR-3015274-T3 (GR)
Title: Novel 3-arylindole and 3-arylindazole derivatives.
Inventor: PERREGAARD JENS KRISTIAN
IPC: C07D413/12
Filed: 1995-03-03
Abstract: 3-Arylindole or 3-arylindazole derivatives having formula: <CHEM> wherein Ar is optionally substituted phenyl or a heteroaromatic group; R<1>-R<4> are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio;  the dotted lines designate optional bonds; X is N or a group CR<6> wherein R<6> is hydrogen, halogen, trifluoromethyl or alkyl, or X is CH2; Y is N or CH, or Y is C ; R<5> is hydrogen, cycloalkyl, cycloalkylmethyl, alkyl or alkenyl, optionally substituted with one or two hydroxy groups, or R<5> is a group taken from structures 1a and 1b : <CHEM> wherein n is an integer from 2 - 6; W is O or S; U is N or CH ; Z is -(CH2)m-, m being 2 or 3, -CH=CH- , 1,2-phenylene or -COCH2- or -CSCH2-; V is O, S, CH2, or NR<7>; U<1> is O, S, CH2 or NR<8>; and V<1> is NR<9>R<1><0>, OR<1><1>, SR<1><2> or CR<1><3>R<1><4>R<1><5>, and R<7>-R<1><5> are independently hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl ; may be prepared by methods known per se. The compounds are selective centrally acting 5-HT2-antagonists in the brain and are useful in treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, drug-induces Parkinsonism and Parkinson's disease.
Patent GR-3018170-T3 (GR)
Title: Enantiomerically selective enzymic acylation of a racemic 3-amino azetidinone.
Inventor: LEVY JEFFREY NEAL
IPC: C07D405/06
Filed: 1995-11-22
Abstract: An enantiomerically selective process for acylating racemic 3-amino azetidinone intermediates is provided using penicillin G amidase(acylase) as biocatalyst.
Patent GR-3018775-T3 (GR)
Title: Cardboard folder.
Inventor: SCHAEFER JOHANNES
IPC: B42F13/00
Filed: 1996-01-24
Abstract: In order to develop further a cardboard folder having a first folder cover and a second folder cover and a securing device with securing tongues and a punched strip, in particular for school use, in such a way that it is less complicated and does not present any new disposal problems, the two folder covers 1, 2 are connected in a foldable manner to a flexible strip 3 of paper, the strip 3 being provided in the longitudinal extent, at least close to its lateral limitations, with a coating of a natural glue or adhesive, by which the connection between the strip 3 and the folder covers 1, 2 can be established; it is advantageous if, in this case, a meltable adhesive, for example a colophony-based glue which can melt under the effect of temperature, is applied in strip form in customary plastics-processing machines to the mutually assigned border regions of the folder covers 1, 2 and/or of the flexible strip 3 and is melted in the welding station, the border regions of the folder covers 1, 2 being adhesively bonded to the flexible strip 3 under the pressure of the welding jaws/rollers. <IMAGE>
Patent GR-3020307-T3 (GR)
Title: Carton with article separating keel structure
Inventor: DOMANSKY PHILIPPE
IPC: B65D71/00
Filed: 1996-06-20
Abstract: A carton accommodating a plurality of articles has an internal keel structure (K) which protrudes inwardly of the carton to form a separator to space apart adjacent articles on either side of the keel structure. The keel structure comprises carton panel portions pairs arranged in spaced relationship with respect to each other. Each panel portion comprises bracing flaps effective to maintain the portions in an upstanding attitude and to create an article retention aperture with which wall portions of an article cooperates to resist dislodgment of the article from the carton. <IMAGE>
Patent GR-3020755-T3 (GR)
Title: Gentechnological preparation of protein PP 15.
Inventor: GRUNDMANN ULRICH DR
IPC: C07K2/00
Filed: 1996-08-08
Abstract: The cDNA coding for PP15 is described. This cDNA can be used to prepare PP15 in pro- or eukaryotic cells. <IMAGE>
Patent GR-3024295-T3 (GR)
Title: 4-heterocycle substituted dihydropyridines
Inventor: JUNGE BODO DR
IPC: C07D401/04
Filed: 1997-07-30
Abstract: 4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with  beta -keto esters and aminocrotonic acid esters, or by esterifying 4-heterocyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.
Patent GR-3031770-T3 (GR)
Title: Novel and improved aminoglycoside formulation for aerosolization
Inventor: SMITH ARNOLD L
IPC: A61P31/04
Filed: 1999-11-05
Abstract: An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible bacteria. Aminoglycoside formulated in 5 ml solution of a quarter normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5  mu , produced by a jet or ultrasonic nebulizer.
Patent GR-3033134-T3 (GR)
Title: Installation for the low temperature separation.
Inventor: ROHDE WILHELM DIPL-ING
IPC: F25J3/04
Filed: 2000-04-04
Abstract: An installation and a process for the low temperature fractionation of air are described. A rectification column (2) is fed with fractionation air via an air pipe (3). It is provided with a nitrogen pipe (14) for the withdrawal of a nitrogen fraction and an oxygen pipe (10) for the withdrawal of an oxygen fraction and a liquid tank (1) for the storage of liquid nitrogen or oxygen, which is enclosed by a vacuum vessel (5). The liquid tank (1) is connected via a first feed pipe (11) to the upper region of the rectification column (2). According to the invention, the liquid tank (1) and the rectification column (2) are arranged in the interior of a shared vacuum vessel (5). <IMAGE>
Patent GR-3035441-T3 (GR)
Title: Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
Inventor: FARINAS KATHLEEN C
IPC: A61K47/30
Filed: 2001-02-20
Abstract: Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug reservoir components to a predetermined temperature. Generally, this temperature is higher than the depressed melting temperature of the polymer-drug admixture which will serve as the drug reservoir. In an alternative embodiment, wherein heat treatment of the reservoir components results in a system having two liquid phases, the predetermined temperature is calculated so as to be higher than the melting temperature of the pure drug. Drug reservoirs and novel transdermal delivery systems prepared using the disclosed techniques are provided as well.
Patent GR-3036840-T3 (GR)
Title: Amorphous monospheric forms of insulin derivatives.
Inventor: OBERMEIER RAINER DR
IPC: C07K14/62
Filed: 2001-10-09
Abstract: A process for the preparation of an amorphous monospheric form of insulin derivatives entails the insulin derivative being dissolved in an n-propanol/buffer mixture at a pH of 4.5 to 6.5, adjusting to an n-propanol content of more than 13% based on water, and subsequently diluting the resulting solution with water.
Patent DK-1496820-T4 (DK)
Inventor: VILLEFRANCE TINE
IPC: A61F5/44
Filed: 2003-04-07
Granted: 2011-12-12
Abstract: A drainable ostomy pouch comprising a first (1) or proximal and a second (2) or distal side wall of flexible sheet material sealed to each other for defining a cavity therebetween for receiving human stomal discharge through an aperture (8a) in the proximal side wall and an elongate drainage portion extending downwardly in a longitudinal direction and ending in a drainage opening (5) extending transversely to the longitudinal direction, a first (6) or proximal and a second (7) or distal flexible stiffening strip of relatively stiff material such as PET, nylon, high density polyethylene or low density polyethylene extending immediately adjacent to and along said drainage opening and being attached for instance by heat sealing or adhesion to the outer surface of the first and second side walls, respectively, of said drainage portion, the pouch further comprising a Velcro strip 9 on the wall 1 and a Velcro strip 10 on a flap 13 for securing a coil comprising the first and second stiffening strips rotated upwards three times.
Patent DK-1629849-T4 (DK)
Inventor: BEELEY NIGEL ROBERT ARNOLD
IPC: C07K14/575
Filed: 1998-01-07
Granted: 2017-12-04
Abstract: A pharmaceutical composition comprising an exendin or an exendin agonist peptide and a buffer, wherein said composition has a pH of from 3.0 to 8.0, provided that the composition is not suspended in an aqueous buffer at a pH of about 5.6 to 7.4.
Patent TR-200402522-T4 (TR)
Inventor: LANG JUERGEN
IPC: G06Q20/00
Filed: 2001-04-24
Abstract: The invention is characterized in that a random number (X) and a payment identification number (PID) which contain information about the customer are generated in the charging point.
Patent TR-201806857-T4 (TR)
Title: Banknot kaseti ve bunun banknot boyutu ayarlama cihazı.
Inventor: XIAOGANG ZENG
IPC: B65H31/20
Filed: 2015-08-05
Abstract: Mevcut başvuru, banknot işleme teknolojileri ile ilgilidir ve hususi olarak da bir banknot kutusu ve bir banknotun bir uzunluğuna ve bir genişliğine uygun olarak ayarlama yapan bir banknot boyutu ayarlama cihazı ile ilgilidir.
Patent TR-201808703-T4 (TR)
Title: Kalsiyum karbonat içeren bir malzeme ihtiva eden bir süspansiyonun üretimine yönelik yöntem.
Inventor: DANIEL GANTENBEIN
IPC: C09D7/45
Filed: 2014-11-07
Abstract: Bu buluş kalsiyum karbonat içeren bir malzemenin üretimine yönelik bir işleme, işlemle elde edilen kalsiyum karbonat içeren bir malzemeye ve kalsiyum karbonat içeren malzemenin kâğıt dolgu maddesi ve kâğıt kaplama uygulamaları için, plastik uygulamalarında, boyalarda, yapıştırıcılarda, sızdırmazlık maddelerinde, betonda, tarım uygulamalarında, gıda uygulamalarında, kozmetik uygulamalarında veya farmasötik uygulamalarda kullanımına ilişkindir.
Patent TR-201809429-T4 (TR)
Title: Yüksekliği ayarlanabilir bir tutamaç ihtiva eden portatif mikser.
Inventor: CARLES GAMISANS BERENGUER
IPC: B28C5/12
Filed: 2012-07-31
Abstract: Bu buluş, inşaat malzemeleri için, harçlar, çimentolar, boyalar, reçineler ve genel olarak her türlü yoğun macun ve sıvı gibi çeşitli malzemeleri karıştırmak için kullanılan bir portatif mikser ile ilgilidir. Portatif mikser, tutamacının yüksekliğinde düzenlemeye izin verecek şekilde yapılmış özel imalat özelliklerine sahiptir, böylece kullanıcı, portatif mikseri tutmak ve kullanmak için tutamacı en uygun yüksekliğe ayarlayabilir.
Patent TR-201810350-T4 (TR)
Title: Oturum sürekliliğinin geliştirilmesi için usuller ve aygıtlar.
Inventor: RALF KELLER
IPC: H04W80/10
Filed: 2010-07-07
Abstract: Bu buluş, iletişime, özellikle terminalin bir ana iletişim ağından ayrı bir hizmet veren iletişim ağındaki bir terminal için oturum sürekliliğinin geliştirilmesine yönelik usullere ve aygıtlara ilişkindir.
Patent TR-201816605-T4 (TR)
Title: Çabuk değiştirilebilen çene geçmelerine sahip yakalama aygıtı, bir iş parçasını yakalamaya yönelik yöntemler ve bu aygıta sahip olan gererek şekillendirme makinesi.
Inventor: CRAIG E TAYLOR
IPC: B21D11/02
Filed: 2005-04-05
Abstract: Buluş, bir profile sahip bir iş parçasını yakalamaya yönelik çabuk değiştirilebilen bir yakalama aygıtı ile ilgilidir. Aygıt, bir birinci (14) ve bir ikinci uca (16) sahip bir silindirik mahfazayı (12) içerir. Silindirik mahfaza bir konik duvara (38) sahip bir iç parçaya (30) sahiptir. Mahfaza ayrıca bir alt bölüme (52) ve alt bölüme menteşe şeklinde bağlanan bir mengene kabuğu bölümüne (50) sahiptir. Çabuk değiştirilebilen aygıt ayrıca, her biri silindirik mahfaza çevresinde düzenlenen bir birinci halkayı (18) ve bir ikinci halkayı (20) içerir.
Patent TR-201901160-T4 (TR)
Title: Elektrik kurulumu için döşeme altı cihaz prizi.
Inventor: JÖRG RASCHKE
IPC: F16B37/08
Filed: 2009-01-08
Abstract: 1. Elektrik kurulumu için döşeme altı cihaz prizi. 2.1. Buluş, binanın zeminine yerleştirilebilir muhafaza alt parçalı ve muhafaza üst parçalı döşeme altı cihaz prizi ile ilgilidir; ve dahası muhafaza üst parçası en az iki dişli saplamayla muhafaza alt parçasına karşı desteklenmektedir; dahası muhafaza üst parçasının mahfaza alt parçasına nispeten yükseklik ayarına yönelik dönme hareketiyle nispeten mahfaza üst parçası boyunca dişli saplama dişi boyunca öngörülmektedir. 2.2. Buluş gereği dişli saplama bir kılavuza alınmakta ve kılavuz alanında dişli saplamasına dönük ucunda iç dişli ile donatılan dişli saplamasına radyal kaydırılabilir kavrama parçası öngörülmektedir. 2.3. Örn. şapla bağlanan döşeme altı cihaz prizlerinde kullanım.
Patent TR-201905089-T4 (TR)
Title: Yumurtalık endometriotik kistin kanserli olması olasılığının belirlenmesine yönelik veri edinim yöntemi ve buna yönelik teşhis cihazı.
Inventor: HIROSHI KOBAYASHI
IPC: G01N33/84
Filed: 2015-03-27
Abstract: Bir yumurtalık endometriozis kistinin kanserli olması olasılığının belirlenmesine yönelik bir endeks olarak harekete edebilen veri edinimine yönelik bir yöntemi sağlamak için. [Çözüm] Bir yumurtalık endometriozis kistinin kanserli olması olasılığının belirlenmesine yönelik bu veri edinim yöntemi, yumurtalık endometriozis kistinin kistik sıvısındaki demir konsantrasyonunun ölçülmesine yönelik bir demir konsantrasyonu ölçme adımını içermektedir. Bir yumurtalık endometriozis kistinin kanserli olması olasılığının teşhis edilmesine yönelik bu teşhis cihazına, yumurtalık endometriozis kistinin kistik sıvısındaki demir konsantrasyonunun ölçülmesine yönelik bir demir konsantrasyonu ölçme birimi minimum sağlanmaktadır.
Patent TR-201905559-T4 (TR)
Title: Az yağlı yağ sürekli emülsiyonların hazırlanması için işlem.
Inventor: TEUNIS DE MAN
IPC: A23D7/005
Filed: 2016-11-08
Abstract: Bir az yağlı yağ-içinde-su emülsiyonunun hazırlanması için bir işlem olup, bu emülsiyon su, sıvı yağ ve bir katı faz yağını içermektedir. İşlem aşağıdaki aşamaları içermektedir: bir sulu faz ve bir yağ fazı bir araya getirilir, burada, yağ fazı katı faz yağını içermektedir ve yağ fazı yağ fazının sıvı olduğu şekilde bir sıcaklıkta bulunmaktadır; müteakiben elde edilen karışım bir yüksek kesme kuvvetli karıştırma tertibatı ile gerçekleştirilen yüksek kesme kuvvetli karıştırmaya tabi tutulur ve burada, yüksek kesme kuvvetli karıştırma işleminden çıkan ürün herhangi bir başka karıştırma işlemi ya da işleme işlemine tabi tutulmadan paketlenmektedir.
Patent DE-10392428-T5 (DE)
Title: Hochfester Leitkupferlegierungsdraht mit hervorragender Beständigkeit gegenüber Spannungsrelaxation
Inventor: HASEGAWA KATSUMASA
IPC: C22F1/08
Filed: 2003-03-12
Abstract: Hochfester
Leitkupferlegierungsdraht mit hervorragender Beständigkeit
gegenüber
Spannungsrelaxation, umfassend 1,0 bis 4,5 Gew.-% Ni, 0,2 bis 1,1 Gew.-%
Si, 0,05 bis 1,5 Gew.-% Sn, und weniger als 0,005 (einschließlich Null)
Gew.-% S, wobei der Ausgleich Cu und unvermeidbare Verunreinigungen
ist, und wobei der Draht eine Leitfähigkeit von 20% bis 60% IACS
und eine Zugfestigkeit von 700 bis 1300 MPa hat.
Patent DE-10393243-T5 (DE)
Title: Messung und Fehlerausgleichung bei Interferometern
Inventor: HILL HENRY A
IPC: G01B11/00
Filed: 2003-09-09
Abstract: Verfahren
zum Bestimmen des Lageorts einer Ausrichtungsmarkierung auf einem
Objekttisch, das Verfahren umfassend:  Messen eines Lageorts,
x 1 , eines Objekttischs entlang einer ersten
Messachse unter Nutzung eines Interferometers;  Messen eines
Lageorts, x 2 , des Objekttischs entlang einer zweiten
Messachse, die im Wesentlichen parallel zur ersten Messachse verläuft; und  Bestimmen
eines Lageorts der Ausrichtungsmarkierung entlang einer dritten
Messachse, die im Wesentlichen parallel zur ersten Messachse verläuft, auf
Grundlage von x 1 , x 2  und
einem Korrekturterm, Ψ 3 , der aus einer vorgegebenen Information
berechnet wird, welche eine Information beinhaltet, die Mängel des
Interferometers kennzeichnet.
Patent ES-2158048-T5 (ES)
Inventor: SHATTUCK-EIDENS DONNA M
IPC: C12P21/02
Filed: 1995-08-11
Granted: 2009-11-04
Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer.