baber/WOPTO huggingface dataset:
Patent IL-177122-A0 (IL)
Title: A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
IPC: G01N1/34
Filed: 2006-07-27
Abstract: An integrated lab-on-a-chip diagnostic system for carrying out a sample preparation process on a fluid sample containing cells and/or particles, the system comprising: (a) an inlet for a fluid sample; (b) a lysis unit for lysis of cells and/or particles contained in the fluid sample; (c) a nucleic acid extraction unit for extraction of nucleic acids from the cells and/or particles contained in the fluid sample; (d) a reservoir containing a lysis fluid; (e) a reservoir containing an eluent for removing nucleic acids collected in the nucleic acid extraction unit; wherein the sample inlet is in fluid communication with the lysis unit, an optional valve being present to control the flow of fluid therebetween; wherein the lysis unit is in fluid communication with the nucleic acid extraction unit, an optional valve being present to control the flow of fluid therebetween; wherein the reservoir containing the lysis fluid is in fluid communication with the lysis unit, an optional valve being present to control the flow of fluid therebetween; and wherein the reservoir containing the eluent is in fluid communication with the nucleic acid extraction unit, an optional valve being present to control the flow of fluid therebetween.
Patent IL-179828-A0 (IL)
Title: Therapeutic agents for the treatment of hmgb1-related pathologies
Filed: 2006-12-04
Abstract: The present invention relates to the use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure for the prevention and treatment of pathologies induced directly or indirectly by the HMGB1 protein.
Patent IL-187205-A0 (IL)
Title: Wrinkle free garment and method of manufacture
IPC: D05B35/00
Filed: 2007-11-06
Abstract: A method of manufacturing wrinkle-free garment seams and garments made therefrom comprises (a) placing a bonding element comprising a thermal adhesive between garment components; (b) stitching along a seam line; and (c) applying heat and/or pressure to cause the adhesive to melt and flow along the seam to bond at least one garment component. The thermal adhesive has a melting point of higher than about 150°C, preferably in the range about 160°C to about 190°C. Alternatively, a bonding element comprising any adhesive material and having a substantially U shape is used to make various seams, such as a yoke seam, a shoulder seam, a side seam, a pocket seam, a hem button stay seam, a sleeve seam, a collar seam, etc. Wrinkle-free garments, such as shirts, pants, blouses, skirts, etc. incorporating the seams are produced.
Patent IL-200250-A0 (IL)
Title: Dibenzo[b,f][1,4]oxazapine compounds
Filed: 2009-08-05
Abstract: The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.
Patent IL-202442-A0 (IL)
Title: Method for producing difluoromethyl-substituted pyrazole compounds
Filed: 2009-12-01
Abstract: The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.
Patent IL-208290-A0 (IL)
Title: Process for the preparation of 10-deacetyl-bis-7, 10- trichloroacetylbaccatin iii
Filed: 2010-09-21
Abstract: The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel ( I )   
a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof.  The invention also discloses a process for the preparation of Docetaxel starting from said compound of formula (I).
Patent IL-208378-A0 (IL)
Title: An infant feeding formula and use thereof
IPC: A23C9/20
Filed: 2004-02-09
Abstract: In one aspect the invention relates to use of nutrient in the manufacture of a feeding formula for feeding to human infants in the period up to 2 months of age to avoid long-term adverse health effects consequent upon excessive weight gain in that period, wherein said feeding formula comprises 0.5 to 1.00 gram of protein or 25 to 50 kilocalories per 100ml. In another aspect the invention provides an infant feeding formula for feeding to babies in the first two weeks of life which is beneficial for long term health and which contains from 0.5 to 1.00 gram of protein per 100ml of formula or 25 to 50 kilocalories per 100ml of formula.
Patent IL-217489-A0 (IL)
Title: Protease screening methods and proteases identified thereby
Filed: 2012-01-12
Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a seipin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
Patent RO-128891-A0 (RO)
Title: Combined fodder for feeding pigs during finishing period
Inventor: LEFTER NICOLETA AURELIA
IPC: A23K1/14
Filed: 2012-11-20
Abstract: The invention relates to a combined fodder used for feeding pigs, preferably during the period of fattening-finishing. According to the invention, the fodder comprises: 42.08% corn, 16% barley, 17% rice flour , 9% soy groats, 12% cameline groats, 0.20% sunflower oil, 0.18% L-lysine, 0.42% mono-calcium phosphate, 1.62% calcium carbonate, 0.40% salt, 0.10% choline premix, 1% vitamin-mineral premix for pigs to be fattened.
Patent RO-130928-A0 (RO)
Title: Integrated fuel supply system for electric diesel locomotive lde 2100 hp using pure biodiesel fuel b100
Inventor: CĂLIN GRAŢIAN GEORGE
IPC: F02M37/22
Filed: 2015-10-06
Abstract: The invention relates to an integrated fuel supply system for an electric locomotive of 2100 HP which uses pure biodiesel fuel B100, in ambient negative temperature conditions. According to the invention, the system comprises a main fuel tank (1) heated with a heating coil (2) and monitored by a temperature sensor (3) wherefrom a main fuel pump (5), using a retaining valve (4), transfers the biodiesel fuel, through some heated supply pipes (6) to a coarse fuel filter (7), to some fine fuel filters (8) and, then, to some injection pumps (9) of a Diesel engine (10), while the excess gas-oil is transferred through a pressure valve (11) to an auxiliary tank (12) and, further on, through some over-flow and return pipes (13 and 14), back to the main tank (1), an equipment (15) for heating and maintaining the Diesel engine (10) supplied in the first place with biodiesel fuel from an auxiliary tank (16) which is electrically heated by an electrical resistor (17) and monitored by a temperature sensor (16), its operation being ensured by a computerized system (34) which monitors the temperature of cooling fluid, lubricating oil and biodiesel fuel in various points of the fuel supply circuit, as well as a series of digital signals (36) from various switching equipments of the locomotive.
Patent RO-135202-A0 (RO)
Title: Process for dual encapsulation of two categories of bioactive plant-based principles in the same nanostructured distribution system
Inventor: LĂCĂTUŞU IOANA
IPC: A61K47/44
Filed: 2021-04-29
Abstract: The invention relates to a process for preparing dual nanocarrier systems to be applied in the treatment of inflammatory diseases. According to the invention, the process consists of the following steps: forming a lipid phase containing a mixture of glyceryl monostearate: cetyl palmitate; evening primrose oil or soybean oil, in a weight ratio of 1: 1: 0.85, the addition, in the lipid phase, of a wild yam extract (EYS), standardized in 95% Diosgenin, which provides a content of 3.3...3.7% bioactive principle in the dual nanostructured lipid carrier (NLC) system, forming an aqueous phase containing a mixture of surfactants tween20: Phosphatidylcholine: Poloxamer 188 in a weight ratio of 1: 0.21: 0.21, addition, in the aqueous phase, of licorice extract (ELD) standardized in 10% glycyrrhizic acid, which provides a content of 3.7...13.2% bio-active principle in the dual NLC system (NLC-EYS-ELD), homogenizing the lipid pre-emulsion and cooling while stirring, at room temperature, followed by lyophilization at -55°C for 60 h, resulting in dual nanocarrier systems which provide a sustained and constant release of the two active principles as well as an enhancement of antioxidant activity and anti-inflammatory effect.
Patent ZM-5481-A1 (ZM)
Title: Borehole charging method
IPC: F42D1/06
Filed: 1981-07-02
Abstract: Method of charging a borehole (15) with a column of explosives (as well as a blasting method) wherein the explosive charge is detonable simultaneously or in time-delay sequence by means of two or more electrically initiated detonators. The method requires providing a loop (8) of an insulated electrical conductor throughout the length of the borehole and, as the borehole is charged with explosives, sliding electrically actuable (time-delay) detonators along the looped wire (8) so as to be positioned at intervals throughout the borehole (15). The detonators are electrically coupled to the looped wire (8) by means of slidable toroidal transformer cores. The wire loop (8), in turn, is electromagnetically energized by means of a second transformer core (4) and an A. C. energy source (1).
Patent ZW-3690-A1 (ZW)
Title: Treatment and compounds
Inventor: HARALD MASCHLER
IPC: C07D473/06
Filed: 1990-03-22
Abstract: A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): <CHEM> or if appropriate a pharmaceutically acceptable salt thereof, wherein R<1> and R<2> each independently represent alkyl or a moiety of formula (a): -(CH2)m-A wherein m represents zero or an integer 1, 2 or 3;   A represents a substituted or unsubstituted cyclic hydrocarbon radical; and R<3> represents a halogen atom, a nitro group, or a group -NR<4>R<5> wherein R<4> and R<5> each independently represents hydrogen, alkyl or alkylcarbonyl or R<4> and R<5> together with the nitrogen to which they are attached forming an optionally substituted, heterocyclic group; certain novel compounds falling within formula (I) and compositions comprising such compounds.
Patent IE-910872-A1 (IE)
Title: Varistor configurations
Inventor: COWMAN STEPHEN P
IPC: H01C17/06
Filed: 1991-03-15
Abstract: In a varistor 31 of generally cylindrical configuration, which may serve as a connector pin, layers of ceramic material 32 are interleaved between layers 33 of electrode material, each ceramic layer 32 being sandwiched between two electrode material layers 33. Each layer 33 of electrode material is generally planar and extends tranversely to the axis of the cylindrical varistor 31, in the form of an annular ring. Each alternate annular ring is of different inner and outer diameter. The outer periphery of each larger diameter annular ring is in electrical contact with an outer terminal cap 35 of the varistor, while the inner periphery of each smaller diameter annular electrode layer 33 is in electrical contact with an inner terminal cap 36 extending along a central bore 37 passing axially through the varistor pin 31. Each ceramic layer 32 may have a thickness dimension less than 30 microns and may be formed by deposition of a powder suspension and subsequent heat treatment to provide a dense continuum of ceramic material of low porosity.
Patent LU-88852-A1 (LU)
Inventor: HAMEL WILLY
IPC: E06B9/00
Filed: 1996-12-13
Abstract: The system consists of a central panel (10) with dimensions to fit the opening, an inflatable tubular surround (20), and a frame (30) which is fixed to the edge of the panel and acts as a guide and support for the tube. The frame has an H-shaped cross-section, with a channel in one side to receive the edges of the panel and a divergent channel in the other to engage with the inflatable tube. The frame can be made e.g. in one piece from aluminium, while the tube is made e.g. from butyl rubber with an outer foam rubber covering and corner members (41) to prevent any gaps.
Patent MA-20677-A1 (MA)
Inventor: VIVIAN CHARLES ASTLEY
IPC: C01B25/234
Filed: 1986-05-08
Abstract: The present invention discloses a new method for obtaining a crystallized phosphoric acid of relatively high purity starting with conventional phosphoric acid. The new method is based on crystallization of orthophosphoric acid hemihydrate from the phosphoric acid. Massive nucleation which would lead to the formation of unprocessable masses is avoided in the new method by providing unusually large amounts of fine relatively pure seed crystals of orthophosphoric acid hemihydrate and operating the crystallization process under conditions which favor crystal growth on the seed crystals and disfavor the occurrence of secondary nucleation. To prevent the crystallizing magma from reaching a viscosity which would render further processing difficult the present invention provides for recycling raffinate in an amount suf­ficient to maintain the solids content of the crystallizing magma below about 40%.
Patent MA-24715-A1 (MA)
Title: Prise telecommandee permettant la coupure ou l'etablissement du courant genere par un panneau photovoltaique.
Inventor: AMIN BENNOUNA
IPC: H01L31/06
Filed: 1998-12-07
Abstract: LA PRÉSENTE INVENTION, QUI VISE à PROCÉDER à UN RÉTABLISSEMENT ET UNE COUPURE DE COURANT à DISTANCE GRâCE à UNE TÉLÉCOMMANDE, OFFRE UNE POSSIBILITÉ  D'INTERVENTION ENVERS LES MAUVAIS PAYEURS, OFFRANT AINSI UNE GARANTIE DE PAIEMENT POUR LES INDUSTRIELS OU DISTRIBUTEURS D'UN TEL MATÉRIEL.L'INVENTION EN QUESTION A POUR OBJET UNE PRISE TÉLÉCOMMANDÉE PERMETTANT L'ALIMENTATION à UNE DISTANCE DES APPAREILS PAR LE SECTEUR (22OV ALTERNATIF), POUR : *   LA COUPURE ET LE RÉTABLISSEMENT, à DISTANCE, UN COURANT GÉNÉRÉ PAR UN PANNEAU PHOTOVOLTAiQUE;  *   LA COMMANDE, à DISTANCE, DU FONCTIONNEMENT DE TOUT APPAREIL FONCTIONNANT AVEC UNE TENSION BASSE ET CONTINUE (12V), TOUT EN ASSURANT SA PROTECTION CONTRE L'INVERSION DE POLARITÉ.
Patent MA-25004-A1 (MA)
Title: Oreille canne pour les aveugles au courant continu 9 volt
Inventor: BLILA MOULAY RACHID
IPC: A61H3/06
Filed: 1999-10-06
Abstract: CANNE ÉLECTRONIQUE POUR LES AVEUGLES,  S'ALLONGE ET S'ACCOURCIT,  CONTENANT UNE CARTE ÉLECTRONIQUE À L'AIDE DU COURANT CONTINU 9V.  AIDONS CES DERNIERS À SE DÉPLACER SANS LE MOINDRE RISQUE, ÉMANANT D'UNE ÉCOUTEUR  ( GAUCHE OU DROITE)  ATTACHÉE À LA CARTE ÉLECTRONIQUE,  QUI CRÉE UNE CONSTANTE FRÉQUENTE ENTENDUE À CAUSE DE LA COUPURE DU FROTTEMENT POUR LEUR SIGNLER L'EXISTANCE D'UN RISQUE (TROU)  POUR FAIRE ATTENTION.      ENFIN LA CANNE EST AUSSI ÉQUIPÉE D'UN FLASHEUR SIGNALANT AUX AUTRES QUE L'AVEUGLE EST EN DANGER SURTOUT DANS LA NUIT.
Patent MA-20150057-A1 (MA)
Title: Cigarette électronique
Inventor: JORDAN GEOFFREY BRANDON
IPC: A24F47/00
Filed: 2013-01-31
Abstract: Article à fumer électronique composé des éléments suivants : un élément d'amenée de liquide comprenant un matériau liquide, un élément chauffant pour chauffer le matériau liquide à une température suffisante pour vaporiser le matériau liquide et former un aérosol, une mèche en communication avec le matériau liquide et en communication avec l'élément chauffant de telle sorte que la mèche achemine le matériau liquide à l'élément chauffant, au moins une entrée d'air permettant d'acheminer de l'air vers un conduit d'air central en amont de l'élément chauffant, et un élément fibreux en aval de l'élément chauffant.
Patent MA-39158-A1 (MA)
Title: Dispositif de production de charbon vert à usage agricole
Inventor: MANSOUR RAWYA LOTFY
IPC: C10B53/02
Filed: 2016-06-29
Abstract: La présente invention concerne un dispositif de production de charbon vert, à usage agricole à partir de matériaux organiques agricoles comportant : un réceptacle (5) apte à recevoir les matériaux organiques, une enceinte (1) renfermant le réceptacle (5) et délimitant un espace intercalaire autour du réceptacle (5), un système de chauffage de l'espace intercalaire et un système de brassage rotatif configuré pour brasser les matériaux organiques placés dans le réceptacle (5) caractérisé par le fait que le système de brassage rotatif comprend une pluralité de pales fixes (15) relativement au réceptacle (5) et une pluralité de pales mobiles (14a, 14b) en rotation relativement au réceptacle (5), la pluralité de pales fixes (15) étant répartie en au moins deux étages de pales fixes (15) suivant l'axe (13) de rotation, la pluralité de pales mobiles (14a, 14b) étant répartie en au moins deux étages de pales mobiles suivant l'axe (13) de rotation, les étages de pales fixes et les étages de pales mobiles étant alternés suivant l'axe (13) de rotation.
Patent UY-23553-A1 (UY)
Title: Util para borrado de pizarras
Inventor: ALCOLEA TORREGROSA JUAN
IPC: A47L25/00
Filed: 1993-03-17
Abstract: Util para borrado de pizarras, esencialmente caracterizado porque comprende la combinación de dos partes o cuerpos, uno constitutivo del cepillo o borrador de pizarras propiamente dicho y otro constitutivo del elemento limpiador de ese cepillo, estando éste limpiador formado por una carcasa de configuración prismática rectangular cuyo fondo está ocupado por un cajón extraible, mientras que la cara superior está afectada central y longitudinalmente de una ranura para el paso de un cuello conformado longitudinalmente entre el propio asidero y el bloque esponjoso del cepillo o borrador; habiéndose previsto que a uno y otro lado de la aludida ranura longitudinal y bajo la cara superior de la propia carcasa vayan situados una pluralidad de tabiques transversales formando rascadores que están afectados de cortes verticales determinantes de aletas flexibles, mientras que los extremos de la propia carcasa están dotados de tapas batientes a través de las cuales previo empuje o extracción de las mismas, es pasante el cuerpo esponjoso del cepillo, cuyo cuello discurre por la ranura longitudinal y superior de la carcasa, quedando por el exterior el asidero o mango de tal cepillo, de manera que el desplazamiento de éste por el interior de la carcasa y su raspado sobre las aletas flexibles de los tabiques transversales conlleva el desprendimiento de polvo y su recogida en el cajón inferior, situándose entre dichas aletas rodillos que favorecen el desplazamiento del borrador en el seno del limpiador. La figura 1 muestra una representación según una perspectiva general del limpiador que forma parte del útil para el borrado de pizarras.
Patent UY-23825-A1 (UY)
Inventor: DR THOMAS JAETSCH
IPC: C07D221/00
Filed: 1994-09-02
Abstract: The present invention relates to novel pyrido[1,2,3-d,e][1,3,4]benzoxadiazine derivatives of the formula (I)   <IMAGE>  in which   R<1> is hydrogen or C1-C4-alkyl which is optionally substituted by hydroxyl or halogen,   R<2> independently of R<1> is hydrogen or methyl,   R<3> is hydrogen or C1-C4-alkyl, R<4> is hydrogen, alkyl having 1 to 4 carbon atoms, which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,   X<1> is hydrogen or halogen,   Z is a radical of the structure   <IMAGE>  wherein   R<7> is hydrogen, hydroxyl, -NR<10>R<11>, hydroxymethyl or -CH2-NR<10>R<11>, carboxyl, methoxycarbonyl or ethoxycarbonyl, where R<10> is hydrogen, C1-C3-alkyl which is optionally substituted by hydroxyl, or alkoxycarbonyl having 1 to 4 C atoms in the alkoxy moiety or C1-C3-acyl, and   R<11> is hydrogen or methyl, R<8> is hydrogen, straight-chain or branched C1-C3-alkyl or cyclopropyl,   R<9> is hydrogen or methyl,   R<6> is hydrogen or methyl, R<5> is hydrogen, methyl or radicals of the structures -CH=CH-CO2R<5'>, -CH2-CH2-CO2R<5'>, -CH2-CO-CH3, -CH2-CH2-CN,   R<5'> is methyl or ethyl,   B is -CH2-, O or a direct bond, their preparation and their use for the therapy or prevention of bacterial infections.
Patent UY-25784-A1 (UY)
Title: Caja de carton sin laminas metalicas revestida de polimeros para el envase de alimentos y productos no alimentarios
Inventor: GIBBONS G A MARANO ALLAN A WHI
Filed: 1999-10-29
Abstract: Se presenta una estructura compuesta sin láminas metálicas que tiene una barrera sustancial contra la pérdida de humedad, oxígeno y vapor orgánico y que puede fácilmente sellarse, con una vida en existencia de al menos un ano, para alimentos y productos no alimentarios, durante su almacenamiento en estante seco, y que es además apropiada en términos ambientales.
Patent UY-26098-A1 (UY)
Title: Proceso para preparar derivados de ácidos ariloxiarilsulfonilamino hidroxamicos
Inventor: ROBINSON RALPH PELTON
IPC: C07C311/29
Filed: 2000-04-04
Abstract: Procedimiento para preparar derivados de ácidos ariloxiarilsulfonamino hidroxámicos de fórmula general (I), representados en la figura 1, o una sal farmacéuticamente aceptable, donde: R1 es (C1-C6) alquilo; R2 es (C1-C6) alquilo; o R1 y R2 considerados junto con el átomo de carbono al cual están unidos forman un anillo seleccionado de (C3-C7) cicloalquilo, 4-tetrahidropiranilo y 4-piperidinilo; R3 es hidrógeno o (C1-C8) alquilo; Y es un sustituyente de cualesquiera de átomos de carbono del anillo de fenilo con capacidad para soportar un enlace adicional, seleccionado independientemente a partir de flúor, cloro, trifluorometilo, (C1-C6) alcoxi, trifluorometoxi, dimetoxi y (C1-C6) alquilo que comprende la reacción con un compuesto de la figura 2 con paladio catalítico en sulfato de bario en un solvente polar. Ejemplos de compuestos preferidos de fórmula (I): Éster etílico del ácido 3-[[4-(4-fluorofenoxi)bencenosulfonil]-(1-hidroxi-carbamoil-ciclopentil)amino]-propiónico; Ácido 3-[[4-(4-fluorofenoxi)bencenosulfonil]-(1-hidroxi-carbamoil-ciclopentil)amino]-propiónico; Éster etílico del ácido 3-[[4-(4-fluorofenoxi)bencenosulfonil]-(1-hidroxicarbamoil-1-metiletil)amino]-propiónico; Áido 3-[[4-(4-fluorofenoxi)bencenosulfonil]-(1-hidroxicarbamoil-1-metiletil)amino]-propiónico; entre otros. Estos compuestos son inhibidores selectivos de la metaloproteinasa- 13 de matriz y como tales, son útiles en el tratamiento de una afección seleccionada del grupo compuesto por artritis, cáncer, ulceración tisular, estenosis recurrente, enfermedad periodontal, epidermólisis vesicular, resorción ósea, movilidad de implantes articulares artificiales, arterosclerosis, esclerosis múltiple, angiogénesis ocular y otras enfermedades caracterizadas por actividad de metalopreteinasa de la matriz.