baber/WOPTO huggingface dataset:
Patent EP-3690059-A1 (EP)
Inventor: VASLIN-CHESSEX ANNE
IPC: C12Q1/68
Filed: 2016-07-21
Abstract: A method of selecting a subject suffering from a cancer for a therapeutic regimen of administration of a pharmaceutical composition comprising an effective amount of an FGFR inhibitor is described, which method comprises (1) the taking of a tumor or liquid biopsy from the subject; (2) determination of the level of expression of any or all of FGFR1, FGFR2 and FGFR3, and (3) comparison of the determined level of expression of at least one of FGFR1, FGFR2 and FGFR3 with a pre-established threshold value, and declaring the subject eligible for the therapeutic regimen if the determined level exceeds the threshold value. The invention also relates to a method of personalized cancer therapy comprising selection of a subject by the above-described method and subjecting the subject to a therapeutic regimen that comprises administration of a pharmaceutical composition comprising an effective amount of an FGFR inhibitor.
Patent EP-3650304-A1 (EP)
Inventor: RODET ALAIN
IPC: B61C9/50
Filed: 2019-11-04
Abstract: L'invention concerne un bogie (10) pour véhicule ferroviaire à plancher abaissé comprenant : 
- un châssis (12); et 
- quatre roues (14) montées sur le châssis (12), chaque roue (14) étant mobile en rotation autour d'un axe de rotation respectif s'étendant selon une même direction transversale (Y-Y'), lesdites roues (14) définissant entre elles un espace (E), l'espace (E) s'étendant entre des plans s'étendue des roues (14) selon la direction transversale (Y-Y'). 
     Le bogie (10) comprend également : 
- quatre moteurs (16), positionnés à l'extérieur de l'espace (E) ; et 
- quatre réducteurs (18), positionnés à l'intérieur de l'espace (E). 
     Chaque moteur (16) entraîne une des roues (14) par l'intermédiaire d'un des réducteurs (18) associé à la roue (14). Chaque roue (14) est mécaniquement indépendante des autres roues (14).
Patent EP-3680329-A1 (EP)
Inventor: NICHOLSON MICHAEL G
IPC: A61P35/00
Filed: 2016-10-05
Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
Patent EP-3674834-A1 (EP)
Inventor: KOSAKI TAKASHI
IPC: G05G1/06
Filed: 2019-12-02
Abstract: To provide an operation lever (21) and a working vehicle (1) having the operation lever (21), which are configured to increase the holding force (the gripping force) acting on the hand during the operation to improve the operability.An operation lever (21) for a working vehicle (1), the operation lever (21) being arranged to one side of an operator seat (10) of the working vehicle (1), includes: a swing body (22) configured to be swingable; and a grip arranged (23) on an upper portion of the swing body (22). The grip (22) includes: a gripping portion (24) arranged to the one side; an operating portion (25) arranged to another side opposed to the one side and provided with an operation switch (30, 31, 32); an extending portion (26) extending backward from a lower portion of the gripping portion (24); and an anti-slip portion (28) arranged between a surface of the gripping portion (24) and a surface of the extending portion (26).
Patent EP-3636608-A1 (EP)
Inventor: SHELESTAK LARRY J
IPC: C03C3/087
Filed: 2014-04-15
Abstract: A glass has a basic soda-lime-silica glass portion, and a colorant portion including total iron as Fe 2 O 3  selected from the group of total iron as Fe 2 O 3  in the range of greater than zero to 0.02 weight percent; total iron as Fe 2 O 3  in the range of greater than 0.02 weight percent to less than 0.10 weight percent and total iron as Fe 2 O 3  in the range of 0.10 to 2.00 weight percent; redox ratio in the range of 0.2 to 0.6, and tin and/or tin compounds, e.g. SnO 2  greater than 0.000 to 5.0 weight percent. In one embodiment of the invention, the glass has a tin side and an opposite air side, wherein the tin side of the glass is supported on a molten tin bath during forming of the glass. The tin concentration at the tin side of the glass is greater than, less than, or equal to the tin concentration in "body portion" of the glass. The "body portion" of the glass extending from the air side of the glass toward the tin side and terminating short of the tin side of the glass.
Patent EP-3838960-A1 (EP)
Title: Verfahren zur einstellung der molekulargewichtsverteilung bei polykondensationen und/oder polyadditionen
IPC: C08G18/32
Filed: 2019-12-17
Abstract: Die Erfindung betrifft ein Verfahren zur Einstellung der Molekulargewichtsverteilung eines Polymers in einer bevorzugt überwiegend irreversiblen Polykondensationsreaktion und/oder Polyadditionsreaktion vom Typ AA+BB. Des Weiteren betrifft die Erfindung das Polymer, das mit dem erfindungsgemäßen Verfahren erhalten wird, sowie die weitere Umsetzung dieses Polymers unter Zudosierung weiterer Monomere. Außerdem betrifft die Erfindung eine Vorrichtung zur Durchführung des erfindungsgemäßen Verfahrens.
Patent EP-3674046-A1 (EP)
Inventor: MAZZANTI VASCO
IPC: B28B1/26
Filed: 2019-12-31
Abstract: A method for manufacturing ceramic products (2); during a pressing step, a blank (4) comprising clay and up to 25% by weight of water is compressed between a first half-mould (5) and a second half-mould (6), so as to obtain a ceramic product (2); during the pressing step, a gas is forced through the first half-mould (5) towards the second half-mould (6); initially, the first and the second half-mould (5, 6) move close to each other, subsequently, they part from each other so as to free part of the gas comprised between the first half-mould (5) and the blank (4); they then move close to each other again to compress the blank (4) and obtain the ceramic product (2).
Patent EP-3588023-A1 (EP)
Title: Ultrasound sensor and detection apparatus
Inventor: ZEQIRI BAJRAM
IPC: H04R17/00
Filed: 2019-07-01
Abstract: A sensor or receiver array (10) includes first and second pyroelectrically active electrodes (12, 14) formed of polyvinylidene difluoride and separated by a spacer layer (16) that acts to electrically separate the pyroelectric layers (12, 14) while keeping them close enough such that they see effectively the same vibration or background acoustic excitation while maintaining sufficient separation to ensure that they generate significant differences in their pyroelectric responses. The structure provides two distinct signals (at separate timestamps), the difference between which provides a more accurate signal. An ultrasound detection system (100) includes the tri-laminar sensor (10), disposed within a detection zone (102) in which a test element (120) can be positioned. The apparatus includes a processing unit (110), which comprises a detector unit (114) coupled to the first and second pyroelectric elements (12, 14) and configured to derive a differential signal from the first and second pyroelectric elements (12, 14). A processor (116) is coupled to the detector unit (114) and is configured to generate an electrical output waveform on the basis of the data extracted from first and second pyroelectric elements (12, 14).
Patent EP-3719144-A1 (EP)
Inventor: IBÁÑEZ DE CÁCERES INMACULADA
IPC: C12Q1/6876
Filed: 2019-04-05
Abstract: The present invention responds to the need to provide an endogenous miRNA for quantifying the amount of one or more targets miRNA in exosomes using normalization, that that does not vary within the different tumor types and within the different chemotherapeutic treatments. This is essential to be able to perform robust analysis of the expression of exosomal miRNAs in these pathologies. So far, other types of endogenous controls have been used that are not strictly exosomal, thus reducing their reliability as normalizers. Therefore, for the first time, an endogenous control specific for the exosomal compartment would be available.
Patent EP-3731373-A1 (EP)
Inventor: PARATI GIAN BATTISTA
IPC: H02K15/04
Filed: 2019-04-23
Abstract: A stator (100) for electric motors, which comprises a plurality of teeth (22, 23) which are arranged circumferentially so as to form a substantially cylindrical hollow body (20) and which between them define a plurality of inner longitudinal cavities (21) which are arranged radially: inside the inner longitudinal cavities (21) there being arranged a plurality of bent wires (J1-J12) which form at least one cylindrical winding (30). 
     The peculiarity of the invention consists in that the teeth (23, 22) comprise a plurality of inner teeth (22) which can be inserted radially from the inside of the cylindrical winding (30) and a plurality of complementary outer teeth (23) which can be inserted from the outside; the inner teeth (22) and the outer teeth (23) being welded together so as to form a continuous ring. 
     The invention also relates to a method for providing such stator and a processing line for carrying out the method.
Patent EP-3746886-A1 (EP)
Inventor: DOUGLAS CLIFTON TIMOTHY
IPC: G06F40/143
Filed: 2019-01-16
Abstract: Described are examples for processing a configuration file having a certain file format for defining static values. One or more static data values defined in the configuration file based on the JSON format can be determined. One or more expressions, defined according to an expression language, can be detected in the configuration file based on the file format. Via a platform engine and based on the expression language, the one or more expressions can be interpreted. The one or more static data values and the one or more expressions can be stored in memory as an in-memory representation of the configuration. An instance of a service for resolving one or more values related to the one or more expressions can be executed by the platform engine and based on the representation of the configuration.
Patent EP-3759136-A1 (EP)
Inventor: GAUDERNACK GUSTAV
IPC: C07K14/725
Filed: 2019-02-27
Abstract: The present invention provides a nucleic acid molecule encoding a specific binding molecule capable of binding an h TERT peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 when the peptide is presented by a Class II Major Histocompatibility Complex (MHC), wherein the specific binding molecule comprises a first polypeptide comprising a variable region of an α-chain and a second polypeptide comprising a variable region of a β-chain of a T-cell receptor (TCR), and wherein: (a) the variable region of an α-chain comprises CDR sequences CDR1, CDR2 and CDR3 which respectively comprise the amino acid sequences set forth in SEQ ID NOs: 2, 3 and 4; and (b) the variable region of a β-chain comprises CDR sequences CDR1, CDR2 and CDR3 which respectively comprise the sequences set forth in SEQ ID NOs: 5, 6 and 7. Recombinant constructs, vectors and host cells comprising such nucleic acid molecules are also provided, as are specific binding molecules encoded by such nucleic acid molecules. The present invention has utility in the treatment of cancer.
Patent EP-3759146-A1 (EP)
Inventor: BORRAS LEONARDO
IPC: A61P35/00
Filed: 2019-03-01
Abstract: Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surface protein of an immune cell, are provided. Methods of making trispecific antigen-binding proteins are provided.
Patent EP-3762309-A1 (EP)
Inventor: KERSHAW RICHARD
IPC: B65D81/20
Filed: 2019-02-25
Abstract: The present invention relates to a container for vacuum skin packaging a product. The container comprises a surface for supporting said product and one or more vacuum vents, wherein the one or more vacuum vents are separated from the supporting surface by one or more separation walls. The invention also relates to a process for vacuum skin packaging a product using said container and a process for forming said container.
Patent EP-3761917-A1 (EP)
Inventor: LONGO MICHAEL A
IPC: A61F2/88
Filed: 2019-03-08
Abstract: Implantable stents that include strips that are each comprised of main struts connected by first connectors, and adjacent strips are connected by second connectors. The strut connectors have a structure, including areas of expanded or reduced width or thickness, to account for venous applications. When used for venous applications, the stents convey benefit from configurations that improve flexibility (due to the greater elasticity of venous applications) while maintaining enough stiffness to resist pressure on the venous structure in selected areas (such as for the May-Thurner syndrome). The stents include particular structural characteristics that are particularly advantageous for (although not limited to) venous applications.
Patent EP-3802765-A1 (EP)
Inventor: ARNDT MATTHIAS
IPC: C08G63/78
Filed: 2019-05-13
Abstract: The invention relates to a polyester comprising two or more of the structural units (a1), one or more of the structural units (a2) and either one or two of the terminal groups (a3) (a1) (a2) (a3) wherein G 1  is one or more of (OC n H 2n ) with n being a number of from 2 to 10, preferably from 2 to 6 and more preferably (OC 2 H 4 ), (OC 3 H 6 ), (OC 4 H 8 ) or (OC 6 H 12 ), R 1  is a C 1-30  alkyl, preferably C 1-4  alkyl and more preferably methyl, p is, based on a molar average, a number of at least 60, preferably from 70 to 200 and more preferably from 90 to 130, q is, based on a molar average, a number of from 0 to 40, preferably from 0 to 30, more preferably from 0 to 20, and most preferably from 0 to 10, where the (OC 3 H 6 )- and (OC 2 H 4 )-groups of the terminal group (a3) may be arranged blockwise, alternating, periodically and/or statistically, preferably blockwise and/or statistically, either of the groups (O-C 3 H 6 )- and (O-C 2 -H 4 )- of the terminal group (a3) can be linked to R 1 - and Ο-, adjacent structural units (a1) are connected by the structural unit (a2), in the case that only one terminal group (a3) is present in the polyester, the other terminal group is selected from the group consisting of OH, OCH 3 , and G 1 OH, and both terminal groups are linked to acyl groups derived from a dicarboxylic acid, preferably to structural units (a1).
Patent EP-3787868-A1 (EP)
Inventor: DUFNER MANFRED
IPC: B29C45/17
Filed: 2019-04-26
Abstract: Die Erfindung betrifft einen Kaltkanalblock in einer vertikal arbeitenden Spritzgießmaschine zur Verarbeitung von elastomeren Materialien mit einer oberen feststehenden Formaufspannplatte und einer darunter angeordneten relativ zur feststehenden Formaufspannplatte beweglichen Formaufspannplatte, zwischen denen ein eine Vielzahl von Formnestern aufweisendes Formwerkzeug angeordnet ist und wobei zwischen der feststehenden Formaufspannplatte und dem Formwerkzeug der Kaltkanalblock angeordnet ist, der eine die Kaltkanäle aufweisende Verteilerplatte und eine Düsenplatte beinhaltet, deren Düsen jeweils einem der mehreren Formnester zugeordnet sind, der dadurch gekennzeichnet ist, dass die aus mehreren Verteilerleisten (10-40) gebildete Verteilerplatte an einer an der feststehenden, angussseitigen Formaufspannplatte befestigbaren Halteplatte (2) angeordnet ist, derart, dass jede Verteilerleiste (10-40) mittels zweier Bolzen (3) mit der Halteplatte (2) verbunden ist, indem der der Verteilerleiste (10-40) abgewandte Kopf (5) des jeweiligen Bolzens (3) ein im Schnitt T-förmiges Halteelement bildet, das in in der Halteplatte (2) eingeformten, im Schnitt komplementär zum Bolzenkopf (5) ausgebildeten Führungsschienen (50) in Richtung quer zur Verteilerleistenlängsachse verschiebbar geführt ist.
Patent EP-3785183-A1 (EP)
Title: Systèmes et procédés de formulation utilisant des résultats de données de revêtement cibles
Inventor: NORRIS ALISON M
IPC: G06N7/00
Filed: 2019-04-26
Abstract: L'invention concerne un système informatique destiné à alimenter un moteur de formulation qui reçoit des données spectrométriques d'un revêtement cible. Le système informatique traite les données spectrométriques par l'intermédiaire d'une analyse de colorant probabiliste. L'analyse de colorant probabiliste génère un ensemble de colorants. Chaque colorant dans l'ensemble de colorants est associé à une probabilité calculée que le colorant associé est présent dans le revêtement cible. De plus, le système informatique ajoute au moins une partie des colorants à l'intérieur de l'ensemble de colorants à un moteur de formulation. La partie des colorants est ajoutée au moteur de formulation afin de diminuer la probabilité. En outre, le système informatique génère, à partir d'une sortie du moteur de formulation, une formulation de revêtement qui est calculée de façon à correspondre au revêtement cible dans un seuil qualitatif prédéterminé.
Patent EP-3973231-A1 (EP)
Inventor: SCHILLER STEPHEN J
IPC: F24S40/90
Filed: 2019-05-22
Abstract: A system (100) and method can monitor a reflectance of a mirror target that includes at least one curved mirror (M). The system (100) can take a first irradiance measurement of the sun (S), the first irradiance measurement representing a direct solar irradiance. The system (100) can take a second irradiance measurement that represents an irradiance from a reflection of the sun (S) from the mirror target plus background irradiance from a reflection of the sky from the mirror target. The system (100) can take a third irradiance measurement that represents the background irradiance from the reflection of the sky from the mirror target. The system (100) can determine a reflectance of the mirror target from the first, second, and third irradiance measurements. The system (100) can compare the reflectance to a specified reflectance threshold, and, upon determining that the reflectance of the mirror target is less than the specified reflectance threshold, can generate an alert signal.
Patent EP-3583531-A1 (EP)
Inventor: LELCUK ALON
IPC: G06F21/62
Filed: 2019-04-15
Abstract: A system and method for blockchain-based access authorization to a protected entity. The method includes: receiving, by the protected entity, an access request to a protected entity, wherein the access request is received from a client device; extracting a unique client identifier from the received access request; causing the client device to perform an admission process; monitoring a blockchain network to identify at least one admission transaction, wherein the at least one admission transaction designates admission criteria; determining if the admission criteria satisfy a set of conditions for accessing the protected entity; and granting access to the client device when the admission criteria satisfies the set of conditions, wherein the access is access to the protected entity.
Patent EP-3802245-A1 (EP)
Inventor: GALIZZI VALERIO
IPC: B60T8/96
Filed: 2019-05-28
Abstract: L'invention concerne un procédé (500) de commande d'un système de freinage d'un véhicule, comprenant les étapes consistant à : détecter (501), par une première pluralité de dispositifs de détection répartis sur le système de freinage du véhicule, des premières informations représentatives d'une condition de mouvement du véhicule ; détecter (502), par une seconde pluralité de dispositifs de détection appartenant à un premier sous-système d'aide à la conduite associé au véhicule, des secondes informations représentant une condition de mouvement du véhicule ; déterminer (503), par un premier bloc de traitement de données, un premier signal de commande d'un module de freinage du véhicule sur la base desdites premières informations et desdites secondes informations ; commander (504), par le premier bloc de traitement de données, le module de freinage du véhicule sur la base du premier signal de commande déterminé.
Patent EP-3813566-A1 (EP)
Inventor: FERRIE KATE
IPC: A24D1/20
Filed: 2019-06-28
Abstract: A method for manufacturing a reconstituted plant material includes the steps of extracting a fibrous plant material with a solvent to provide an extract and a fibrous portion, separating the extract from the fibrous portion, concentrating the extract to provide a concentrated extract, forming a base sheet from the fibrous portion, combining a flavouring contained within a humectant or nicotine contained within a humectant with the concentrated extract, and applying the concentrated extract to the base sheet.
Patent EP-3986352-A1 (EP)
Title: Absorbent article with function-formed topsheet, and method for manufacturing
Inventor: ARORA KELYN ANNE
IPC: A61F13/511
Filed: 2019-06-19
Abstract: An absorbent article is disclosed. The article includes a topsheet formed of a section of formed nonwoven web material having an ordered arrangement of zones, each zone comprising one or more attenuated regions adjacent to one or more built-up regions, wherein the attenuated regions have a first average basis weight and the built-up regions have a second average basis weight, wherein the first average basis weight is less than the second average basis weight, the difference in basis weights corresponding to disposition of the filaments according to the ordered arrangement. The attenuated region(s) may include a plurality of discrete low bulk portions arranged in a pattern disposed along a longitudinal axis of the article, which facilitate z-direction movement of fluid through the topsheet and inhibit spreading of a fluid stain along the topsheet in the x and y directions.
Patent EP-3722198-A1 (EP)
Inventor: CHERNIAVSKYI VALENTYN FEODOSEVYCH
IPC: B63B5/24
Filed: 2019-01-16
Abstract: Methods for manufacturing floating pontoon blocks, and pontoon blocks produced using such methods are claimed. According to the above-mentioned methods, a polymer raw material is extruded with the aid of an extruder (2), the raw material being recycled polyethylene, a product of refuse recycling. In the methods, vacuum stabilisation and cooling is carried out following extrusion, then the finished section of the product is stretched with the aid of stretching devices (7) and the finished section is cut up into pieces of the required size and shape using saws (8), after which the manufacturing holes are sealed. Several extruders positioned in parallel and joined by a common head unit can be used. Extruders with several head units can be used. Virgin polyethylene can be added to the recycled polyethylene.
Patent EP-3810919-A1 (EP)
Inventor: GALLIENNE FELIX
IPC: F02P5/152
Filed: 2019-06-03
Abstract: L'invention porte sur un procédé d'application d'une dégradation d'avance (DegAV) à l'allumage curative d'une première valeur (Deg n) nominale prédéterminée pour un moteur thermique après une détection d'un premier coup de cliquetis (Cl1, Cl2, Cl5) lors du fonctionnement du moteur, caractérisé en ce que l'application de la dégradation d'avance (DegAV) à l'allumage curative est suspendue tant qu'un deuxième coup de cliquetis (Cl3) n'a été détecté dans un premier intervalle de temps (T1s) prédéterminé débutant avec la détection du premier coup de cliquetis (Cl1, Cl2, Cl5).
Patent EP-3829870-A1 (EP)
Inventor: GORIN CRAIG F
IPC: C09D11/106
Filed: 2019-07-12
Abstract: A method of fused filament fabrication (FFF) additive manufacturing comprises employing a thermoplastic blend comprised of high density polyethylene and a second thermoplastic polymer, wherein the second polymer is a low density polyethylene (LDPE), functionalized polyolefin or combination thereof and the amount of high density polyethylene to the amount of second thermoplastic polymer by weight is a ratio from 1.5/1 to 20/1. LDPE means a polyethylene that have been radically polymerized at high pressure. The method allows for the additive manufacturing article that retains the desirable mechanical properties of HDPE without experiencing the problems inherent in FFF printing of HDPE or use of solid fillers. In a particular embodiment, the additive manufactured article has a continuous phase and the second thermoplastic polymer is present as a discontinuous phase within the additive article manufactured article and the filament used to make the article.