Patent SG-11201805066R-A (SG)
Title: Alkyl dihydroquinoline sulfonamide compounds
Inventor: WEISS MATTHEW
IPC: C07D403/12
Filed: 2016-12-19
Abstract: asto applicant's entitlement to apply for and be granted a patent (Rule .1700) ished: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (51) International Patent Classification: CO7D 403/12 (2006.01) A61K 31/4704 (2006.01) CO7D 413/12 (2006.01) A61P 29/00 (2006.01) (21) International Application Number: PCT/US2016/067617 (22) International Filing Date: 19 December 2016 (19.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/269,518 18 December 2015 (18.12.2015) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). arations under Rule 4.17: (72) Inventors: WEISS, Matthew; 99 Revere Street, Boston, Massachusetts 02114 (US). MILGRAM, Benjamin C; 36 Decl Ash Street, Apt. 101, Cambridge, Massachusetts 02138 (US). MARX, Isaac E.; 7 Michael Street, Arlington, Mas- sachusetts 02474 (US). DINEEN, Thomas; 36 Waterhouse Street, Somerville, Massachusetts 02144 (US). Publ (74) Agent: LEMOINE, Elsa; Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, W O 20 17 / 10687 1 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/106871 Al 22 June 2017 (22.06.2017) WIPO I PCT (54) Title: ALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS (I) R 5c R 5 d (57) : The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are in- hibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders, cough, and itch. Also provided are pharmaceutical compositions con- taining compounds of the present invention. 111111111111110111010101111101011111011101011011111111101111101111111110111111