baber/WOPTO huggingface dataset:
Patent EA-000346-B1 (EA)
Title: A process for the preparation of lercanidipine hydrochloride
Inventor: LEONARDI AMEDEO
IPC: C07D211/90
Filed: 1996-05-09
Abstract: 1. A process for the preparation of methyl l,l,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)--pyridine-3,5-dicarboxylate (lercanidipine) hydrochloride, the process comprising: a)halogenating 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-l,4-dihydro-pyridine-3-carboxylic acid with a halogenating agent in an aprotic solvent; b) adding 2,N-dimethyl-N-(3,3-diphenylpropyl)-l-amino-2-propanol dissolved in an aprotic solvent to the resultant acid halide; and c) isolating the resultant lercanidipine as its anhydrous hydrochloride. 2. A process according to Claim 1 wherein the halogenating agent is thionyl chloride, phosphorus pentachloride, phosphorus trichloride, phosphorus oxychloride or oxalyl chloride. 3. A process according to Claim 1 or 2 wherein the aprotic solvent in which the balogenation is effected is chloroform, dichloromethane, dichloroethane, chlorobenzene, 1,1,1-trichloroethane, ethyl acetate, methyl acetate, tetrahydrofuran, dioxane, dimethylformamide, dimethylcarbonate or a mixture of two or more thereof. 4. A process according to any preceding Claim wherein the aprotic solvent used to dissolve the 2,N-dimethyl-N-(3,3-diphenylpropyl)-l-amino-2-propanol is chloroform, dichloromethane, dichloroethane, chlorobenzene, 1,1,1-trichloro-ethane, ethyl acetate, methyl acetate, tetrahydrofuran, dioxane, dimethyformamide, dimethylcarbonate, toluene, xylene, an alkane having from 5 to 7 carbon atoms, a cycloalkane having from 5 to 7 carbon atoms or a mixture of two or more thereof. 5. A process according to any preceding Claim wherein the lercanidipme is isolated by crystallization. 6. A process according to Claim 5 wherein the crystallization is carried out in two successive steps, alternating aprotic and protic solvents. 7. A process according to Claim 6 wherein the aprotic crystallization solvent is ethyl acetate, methyl acetate or acetone. 8. A process according to Claim 6 or 7 wherein protic crystallization solvent is one or more of methanol, ethanol, n-propanol, i- propanol, n-butanol, s-butanol and t-butanol, optionally in admixture with water.
Patent EA-002466-B1 (EA)
Title: Device for spreading an agricultural product
Inventor: PLATTNER CHAD ERIC
IPC: A01C7/06
Filed: 2000-02-26
Abstract: 1. A device (10) for spreading a product, comprising a tool holder (14), a drive shaft (40) fixed to the tool holder (14) and a plurality of spreader units (12) which is mounted on the tool holder (14) and has a dosing device (24, 36) for metering doses of product to be spread, notably seed and/or chemicals, wherein the tool holder (14) and the drive shaft (40) are arranged crosswise the motion in front of the device (10), characterized in that comprises a flexible, rotating shaft (51, 62) which is kinematically linked to the drive shaft (40) and dosing device (24, 36) in a driving fashion. 2. A device of claim 1, characterized in that comprises a first driving gear (42) positioned between the flexible shaft (51) and the drive shaft (40) for driving the flexible shaft (51) by the drive shaft (40). 3. A device of claims 1 or 2, characterized in that comprises a second driving gear (54) positioned between the flexible shaft (51) and the dosing device (24) for driving the dosing device by the flexible shaft (51). 4. A device of claims 2 or 3, characterized in that the first driving gear (42) is provided with a driving wheel (46), which is rigidly connected to the drive shaft (40) and the second driving wheel (48) which is in a mesh with the driving wheel (46) for driving the flexible shaft (51). 5. A device of claims 3 or 4, characterized in that the second driving gear (54) is provided with a driving drive wheel (56) which is rigidly connected to the drive shaft (51), and a second driving driven wheel which is in mesh with the driving wheel (58) for the dosing device (24) driving. 6. A device of any of claims 1 to 5, characterized in that the dosing device (36) for chemical spreading is designed enabling to be driven by the second flexible rotating shaft (62). 7. A device of any of claims 1 to 6, characterized in that the flexible shaft (51, 62) is arranged a flexible non-rotating casing (52). 8. A device of any of claims 1 to 7, characterized in that the spreader units (12) is a sowing and planing unit.
Patent EA-005291-B1 (EA)
Title: Pregelatinized starch in a controlled release formulation
Inventor: VANDECRUYS ROGER PETRUS GEREBE
IPC: A61K47/48
Filed: 2000-03-24
Abstract: 1. Use of pregelatinized starch in a hydrophilic controlled release formulation comprising one or more active ingredients and one or more viscous hydrophilic polymers to counter the impairing effect of ionic strength of the release medium on the controlled release of active ingredient (s) from said formulation. 2. Use of pregelatinized starch in a hydrophilic controlled release formulation comprising one or more active ingredients and one or more viscous hydrophilic polymers to maintain a controlled release of active ingredient (s) from said formulation in release media with changing ionic strength. 3. Use of pregelatinized starch according to claim 1 or 2 wherein the ionic strength of the release medium ranges up to 0.4. 4. Use of pregelatinized starch according to claim 1 or 2 wherein the ionic strength of the release medium is that encountered along the entire gastro-intestinal tract both in fasted as well as in fed conditions. 5. Use of pregelatinized starch according to claim 1 or 2 wherein the ionic strength of the release medium ranges from about 0.01 to about 0.2. 6. Use of pregelatinized starch in a hydrophilic controlled release formulation comprising one or more active ingredients and one or more viscous hydrophilic polymers to prevent dose-dumping from said formulation along the gastro-intestinal tract both in fasted as well as in fed conditions. 7. Use of pregelatinized starch according to claims 1, 2 or 6 wherein the hydrophilic controlled release formulation further comprises pharmaceutically acceptable formulating agents. 8. A hydrophilic controlled release formulation according to any one of claims 1-7 comprising pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents characterized in that the pregelatinized starch enables the formulation to maintain a controlled release of the incorporated active ingredient (s) in release media with changing ionic strength. 9. A formulation according to claim 8 having the following composition: Active ingredient (s) 0.01-50% (w/w), Viscous hydrophilic polymer (s) 0.01-80% (w/w), Pregelatinized starch 0.01- < 80% (w/w), Pharmaceutically acceptable formulating agents ad 100% (w/w). 10. A formulation according to claim 9 wherein the viscous hydrophilic polymer comprises hydroxypropyl cellulose. 11. A formulation according to claims 8, 9 or 10 further comprising a water soluble polymer as dissolution-rate enhancer. 12. A formulation according to claim 11 wherein the water soluble polymer is hydroxypropyl beta-cyclodextrin. 15. A formulation according to any one of claims 8, 9, 10, 11 or 12 wherein comprising a dosage form shaped as an optionally coated tablet.
Patent EA-003920-B1 (EA)
Title: Method of impulse purchase for pay-television
Inventor: KUDELSKY ANDRE CH
IPC: H04N21/4623
Filed: 2000-07-06
Abstract: 1. Method for selecting and confirming an impulse purchase for pay television comprising the presentation to a user, by means of a display device, of a grid of programs, and the selection by this user of a program of his particular choice from the grid by means known per se, this choice having to be confirmed in the system by an entitlement management message (EMM), this message being specific to an impulse purchase, characterized in that the entitlement management message (EMM) specific to an impulse purchase is contained in the data (SI) tied to the presentation of the program grid. 2. Method according to Claim 1, characterized in that the entitlement management message is used locally in a hardware subassembly installed at the user's premises, this hardware subassembly comprising a security module in which is stored a subscriber authorizations and subscriptions profile relating to the user. 3. Method according to Claim 1, characterized in that the entitlement management message specific to an impulse purchase may entail either the notification to authorize viewing, or that to veto this viewing authorization. 4. Method according to Claim 1, characterized in that the entitlement management message (EMM) comprises conditions defining the authorization of viewing and conditions of cancellation of this authorization.
Patent EA-006297-B1 (EA)
Title: Enterosorbent for therapy of liver impairment
Inventor: PLENINA LJUDMILA VASILIEVNA
IPC: A61K33/44
Filed: 2002-05-03
Abstract: The invention relates to medicine and pharmacology and can be used in complex treatment of patients suffering from liver and bile-excreting tract diseases. An enterosorbent "Diasorba" is proposed for therapy of liver impairment which contains carbon high disperse material and a filler with the following ingredient ratio, wt%: Activated carbon fibre AUT-MI  4.75; Microcrystalline monocarboxycelloloe  95.09; Oxybenzoic acid methyl ether-n (nipagin)0.16. The enterosorbent is effective for conservative therapy of liver impairment of different aetiology.
Patent EA-007765-B1 (EA)
Title: Burail coffin
Inventor: AGARKOV ALEXANDER MIKHAILOVICH
IPC: A61G17/00
Filed: 2005-08-15
Abstract: The invention relates to ritual articles, namely to coffins and can be used in crematoria during funeral ceremony.According to the first embodiment the coffin consists of casing including a bottom part, side walls and end walls rigidly connected and a lid tightly stuck to the upper edges of the side walls and provided with guide elements. The novelty is characterized in that the casing and the lid are manufactured from gas-filled polymer material, the bottom part and side walls constitute an integral part, wherein equally spaced traverse grooves with strengthening bands therein are made on the outer surface of the bottom part and on the side walls un their lower part. The lid guide elements are made as longitudinal projections the outer side surface of which mates with the inner surface of the casing side walls.According to the second embodiment the coffin has the lid sectional in its medium part along the diametral line while the guide elements of each lid section are made as longitudinal projections the outer side surface of which mates with the inner surface of the casing side walls.The casing and the lid can be made from gas-filled polymer material of rigid type or integral type with monolithic surface layer based on polyurethane or polysterene or polyvinylchloride. The outer surface may have a decorative ornament, and the casing and the lid are joined by an adhesive tape.The end edges of the side walls and the bottom are arranged in a U-shaped cut made on one of the end wall side and fixed to it by an adhesive tape.The casing has supports which can be manufactured as one piece with the casing.Belts are used as strengthening elements.Handles are provided on the side walls of the casing which can be decorative.
Patent EA-011403-B1 (EA)
Title: 3-(4-heteroarylcyclohexylamino) cyclopentanecarboxamides as modulators or chemokine receptors
Inventor: XUE CHU-BIAO
IPC: C07D471/02
Filed: 2005-05-10
Abstract: The present invention is directed to compounds of Formula (I)which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
Patent EA-014176-B1 (EA)
Title: Device for treating and purifying a liquid product
Inventor: KISTEREV VALERIY EVGENIEVICH
IPC: B01D35/04
Filed: 2008-07-02
Abstract: The invention relates to the food industry. A liquid product is treated and purified being passed through a mixture of sorbing components confined between filtering materials. Each portion of vodka poured from a bottle into a drinking vessel prior to be consumed is treated and purified by the consumer himself by pressing it from the bottle at an optimal flow rate through a primary filtering material, sorbent(s) and a fine filtering material, which are placed in a cartridge body, using air pressure of the necessary value inside the bottle produced, as necessary, by means of a small-sized air pump which is arranged outside of the bottle in a body and is connected to an electrical micromotor.
Patent EA-015087-B1 (EA)
Title: Device for holding cutting tool
Inventor: BONDAREV KONSTANTIN DMITRIEVICH
IPC: E21C35/19
Filed: 2009-05-25
Abstract: The invention relates to mining machinery, in particular, to holding a cutting tool at an executive member of mining machinery for development of salt and coal deposits. A device for holding a cutting tool comprises a cutting tool holder with a wedge-shaped groove, in which the wedge and the cutting tool, the wedge has toothed projections located in toothed recesses made on the cutting tool surface being in contact with the wedge, and besides the wedge is pressed by a spring towards narrowed portion of the wedge-shaped groove, the device is characterized in that the wedge is positioned between the front portion of the cutting tool holder and the front plane of the wedge-shaped groove holder, wherein the toothed recesses on the cutting tool surface are disposed at its tail portion at a stretch not exceeding one third of the cutting tool length from the end face of the cutting tool tail part. The advantage of the proposed invention lies in high fatigue strength of a tangent cutting tool with simultaneously providing reliable and free of gap cutting tool holding leading to considerable cutting tool life time and consequently increases an overhaul period of the executive member of mining machinery. The proposed invention excludes practically cutting tool losses during machinery operation and provides their easy replacement. Holding procedure was tested on two mining machines during one month.
Patent EA-016334-B1 (EA)
Title: Concentrate burner
Inventor: SIPILA JUSSI
IPC: C22B15/00
Filed: 2008-09-01
Abstract: A concentrate burner for feeding a pulverous concentrate mixture and reaction gas into the reaction shaft (1) of a flash smelting furnace. The concentrate burner includes a feeder pipe (2) for feeding the concentrate mixture into the reaction shaft (1), the orifice (3) of the feeder pipe opening to the reaction shaft, a dispersing device (4), which is arranged concentrically inside the feeder pipe (2) and which extends to a distance from the orifice inside the reaction shaft (1) for directing dispersing gas to the concentrate mixture flowing around the dispersing device. For feeding the reaction gas into the reaction shaft (1), a gas supply device (5) includes a reaction gas chamber (6), which is located outside the reaction shaft and opens to the reaction shaft (1) through an annular discharge orifice (7) that surrounds the feeder pipe (2) concentrically for mixing the reaction gas discharging from the discharge orifice with the concentrate mixture discharging from the middle of the feeder pipe, the concentrate mixture being directed to the side by means of the dispersing gas. The reaction gas chamber (6) comprises a turbulent flow chamber, to which an inlet channel (9) opens tangentially for directing the reaction gas to the reaction gas chamber in a tangential direction. In the inlet channel (9), an adjusting member (11) is arranged for adjusting the cross-sectional area of the reaction gas flow.
Patent EA-019220-B1 (EA)
Title: System and method for sensing pressure using an inductive element
Inventor: THOMPSON M CLARK
IPC: G01L9/12
Filed: 2008-07-30
Abstract: Exemplary systems and method are directed to a sensing device, and to a pressure sensing system and method. An exemplary method includes supplying electromagnetic energy to a transducer which is configured to reflect the electromagnetic energy at a ring frequency determined by an inductance of the transducer, wherein the inductance changes in response to compression of the inductive element. The ring frequency of electromagnetic energy reflected by the transducer is correlated to a pressure value.
Patent EA-020538-B1 (EA)
Title: Pharmaceutical composition having neuroprotective, antiamnesic, antioxidant, antihypoxic and anti-ischemic activity (variants)
Inventor: CHELYAEVA ANASTASIYA GENNADIEVNA
IPC: A61P3/00
Filed: 2012-03-20
Abstract: The invention relates to the pharmaceutical industry and medicine. The aim of the present invention is to create an effective pharmaceutical composition having neuroprotective, antiamnesic, antioxidant, antihypoxic and anti-ischemic activity. The aim is solved by that the pharmaceutical composition comprises 2-ethyl-6-methyl-3-hydroxypyridine succinate, peptide Met-Glu-His-Phe-Pro-Gly-Pro and differs from the prototype by further comprising mineral substances: potassium, magnesium, iron, manganese, zinc. Moreover, in the pharmaceutical composition, some of theC carbon isotopes are substituted byC carbon isotopes. The technical results of the invention are a more rapid onset of therapeutic effect, an enhanced therapeutic effect with no increase in the concentration of the 2-ethyl-6-methyl-3-hydroxypyridine succinate preparation and peptide Met-Glu-His-Phe-Pro-Gly-Pro, and improved stability for the duration of the shelf life.
Patent EA-026813-B1 (EA)
Title: Method and apparatus for applying plasma particles to a liquid and use thereof for disinfecting water
Inventor: ZOLEZZI-GARRETON ALFREDO
IPC: H05H1/00
Filed: 2011-02-09
Abstract: The invention provides a method and apparatus for creating plasma particles and applying the plasma particles to a liquid. Liquid feedstock (e.g., water and/or hydrocarbons mixed with biomass) is pumped through a pipeline; the single-phase stream is then transformed into a biphasic liquid-and-gas stream inside a chamber. The transformation is achieved by transitioning the stream from a high pressure zone to a lower-pressure zone. The pressure drop may occur when the stream further passes through a device for atomizing liquid. Inside the chamber, an electric field is generated with an intensity level that exceeds the threshold of breakdown voltage of the biphasic medium leading to a generation of a plasma state. Furthermore, the invention provides an energy-efficient highly adaptable and versatile method and apparatus for sanitizing water using plasma particles to inactivate biological agents contaminating water.
Patent EA-023019-B1 (EA)
Title: Method for making a catalyst comprising a phosphorus modified zeolite to be used in an alcohols dehydration process
Inventor: NESTERENKO NIKOLAI
IPC: C07C1/24
Filed: 2011-01-25
Abstract: The present invention is a method for making a catalyst to convert an alcohol into light olefins in a dehydration process, wherein said catalyst comprises a phosphorus modified zeolite, comprising the following steps: a) the phosphorus is introduced into a zeolite comprising at least one ten-members ring in the structure, b) the phosphorus modified zeolite of step a) is mixed with at least a component selected among one or more binders, salts of alkali-earth metals, salts of rare-earth metals, clays and shaping additives, b)* a catalyst body is made from mixture b), c) a calcining.
Patent EA-024542-B1 (EA)
Title: Soil additives for promoting seed germination and prevention of evaporation and methods for using the same
Inventor: CRISTOBAL GALDER
IPC: C05G3/80
Filed: 2011-04-26
Abstract: The present invention relates to methods of improving germination rates of plants or crops, and of preventing or arresting water evaporation loss from targeted soil areas by use of soil additives, which allow for improved water utilization by crops, plants, grasses, vegetation, etc.
Patent EA-024814-B1 (EA)
Title: Medical device containing a cake composition comprising aripiprazole as an active ingredient, and a cake composition comprising aripiprazole as an active ingredient
Inventor: HIRAOKA SHOGO
IPC: A61M5/00
Filed: 2012-01-17
Abstract: The present invention provides a medical device containing a cake composition comprising aripiprazole as an active ingredient and capable of suppressing agglomeration of aripiprazole in a suspension obtained by resuspending a freeze-dried substance; and a cake composition comprising aripiprazole as an active ingredient. The present invention relates to a medical device containing, in a storage container whose inner wall is treated with silicone, a freeze-dried cake composition comprising separately prepared aripiprazole as an active ingredient, wherein there is a space between the inner wall and the cake composition; and a cake composition comprises aripiprazole as an active ingredient and has a strength of 5 to 100 N.
Patent EA-030000-B1 (EA)
Title: Method for mature oocyte development stimulation
Inventor: CHENG YUAN
IPC: C12N5/00
Filed: 2012-12-14
Abstract: The invention provides a method for mature oocyte development stimulation including either in vitro interaction, or using intraovarian injection or systemic administration, in vivo interaction of ovarian tissue during 1 h to 5 days either with C-type natriuretic peptide (CNP) or fused CNP protein, or with R-spondin protein or fused R-spondin protein, or with them both in a dose effective for mature oocyte development stimulation. In addition, the method for stimulation of mammalian preantral follicle development to antral follicle stage includes: in vitro interaction of at least one mammalian ovary preantral follicle during 1 h to 5 days with C-type natriuretic peptide (CNP) or fused CNP protein, in a dose effective for activation of mammalian ovary follicle.
Patent EA-026458-B1 (EA)
Title: Method of treating hair
Inventor: MURRAY ANDREW MALCOLM
IPC: A61Q5/04
Filed: 2013-04-15
Abstract: A process of straightening the hair comprising the following consecutive steps: i) applying to dry hair a hair treatment composition having a pH of 3 or less at 20°C and comprising at least 4 wt.% of the total composition of a bidentate or tridentate carboxylic acid; ii) leaving the product on the hair for at least 5 minutes; iii) rinsing the product from the hair; and iv) combing.
Patent EA-029246-B1 (EA)
Title: Method for gas cleaning of solid particles
Inventor: AKULICH ALEXANDER VASILIEVICH
IPC: B01D50/00
Filed: 2015-04-01
Abstract: In a swirl-type dust-collecting separation chamber (1), centrifugal gas cleaning of dust is performed in the mode of interaction of a peripheral flow (2) and a central flow (3) of gas suspension that are swirled to one side and directed toward each other. Cleaned gas formed at the stage of centrifugal collection is discharged, in the mode of central ascending flow, through an exhaust pipe (4) into gas redistribution chamber (5) for final cleaning. Final cleaning of gas being cleaned is performed in the mode of rotational-translational ascending motion of two continuous annular flows, inner and outer, along the inner (7) and outer (8) side surfaces of an annular channel (6) formed by side surfaces of filtering elements having their bottom parts connected by a toroidal surface (9) of an additional filtering element on the principle of external filtration inwards the annular channel (6). Maintenance of the shape of the annular channel (6) during external filtration through the integral filtering element formed is provided by means of a sleeve grid (10) and supporting frames (11). Cleaned gas is discharged from the apparatus as a single flow that is formed completely in the upper part, above the annular channel (6), through a pipe (12) in the top part of the device. The invention provides high efficiency of the process of gas cleaning from dust while reducing hydraulic resistance.