baber/WOPTO huggingface dataset:
Patent BR-112022018471-A2 (BR)
Title: Limpeza no local de refrigerador de aves inteiras
Inventor: DARIN L CHANCELLOR
IPC: A22B5/00
Filed: 2021-03-17
Abstract: LIMPEZA NO LOCAL DE REFRIGERADOR DE AVES INTEIRAS. Um refrigerador de aves compreende um tanque tendo um transportador dentro do interior para impelir aves para movimento ao longo do tanque, em que o tanque tem uma abertura que se estende ao longo de um comprimento do tanque, e um sistema de limpeza para limpar automaticamente o interior do tanque, o sistema de limpeza compreendendo uma pluralidade de bocais de distribuição que se estendem ao longo do tanque para direcionar o fluido de limpeza para a superfície interior do tanque. São fornecidos kits de adaptação para automatizar a limpeza no local dos tanques de refrigerador.
Patent BR-112022021027-A2 (BR)
Title: Anticorpos de quimiocina pan-elr+ cxc para o tratamento de doença respiratória
Inventor: DERRICK R WITCHER
IPC: C07K16/24
Filed: 2021-04-16
Abstract: anticorpos de quimiocina pan-elr+cxc para o tratamento de doença respiratória. a presente invenção refere-se a métodos e usos de anticorpos que ligam todas as sete quimiocinas elr+ cxc humanas com alta afinidade para prevenção e/ou tratamento de doenças respiratórias, como por exemplo, síndrome do desconforto respiratório agudo (ards). a presente invenção também se refere a doses e regimes de dosagem para os métodos e usos dos anticorpos que ligam todas as sete quimiocinas elr+ cxc humanas com alta afinidade para prevenção e/ou tratamento de doenças respiratórias, como por exemplo, a ards.
Patent BR-112022025640-A2 (BR)
Title: Conjunto de bocal de pulverização montado em barra com design compacto de múltiplos bocais de pulverização
Inventor: TREVOR PRICE
IPC: B05B1/16
Filed: 2021-06-18
Abstract: CONJUNTO DE BOCAL DE PULVERIZAÇÃO MONTADO EM BARRA COM DESIGN COMPACTO DE MÚLTIPLOS BOCAIS DE PULVERIZAÇÃO. Uma barra de pulverização de líquido para suportar uma pluralidade de conjuntos de bocais de pulverização, cada um com um design compacto que permite a transferência e armazenamento da barra de pulverização com menor tendência a danos. Os conjuntos de bocais de pulverização incluem, cada um, uma seção de entrada de líquido e um par de bocais de pulverização de suprimento de líquido e pernas de suporte que se estendem a partir da seção de entrada de líquido em relação transversal dianteira à barra de pulverização e em um ângulo agudo entre si. Um bocal de pulverização é montado de forma removível em cada perna de suprimento de líquido de corpo de bocal com uma respectiva válvula de retenção disposta em relação à retaguarda do bocal de pulverização. A seção de entrada de líquido, o corpo em Y e os componentes de suporte para os bocais de pulverização e a válvula de retenção são adaptados para montagem e desmontagem de desconexão rápida.
Patent BR-112023002176-A2 (BR)
Title: Máquina de lavar roupa
Inventor: HIROKI KONDOH
IPC: D06F39/14
Filed: 2021-08-23
Abstract: MÁQUINA DE LAVAR ROUPA. A presente invenção refere-se a máquina de lavar (10A) que inclui armação superior (24) disposta como uma parte superior da carcaça (11), boca de carregamento de roupas (24a) formada na estrutura superior (24) através da qual a roupa a ser lavada é carregada nela, e tampa (25) que cobre de forma passível de abrir a boca de carregamento de roupas (24a). A tampa (25) inclui uma placa de tampa (26), componentes do eixo de rotação da tampa (28), e eixos de rotação da tampa (29). O componente do eixo de rotação da tampa (28) é fixado a um lado posterior da placa da tampa (26) em um lado posterior da máquina de lavar (10A) com a tampa (25) fechada, na orientação instalada. O eixo de rotação da tampa (29) suporta de forma rotativa o componente do eixo de rotação da tampa (28). O espaço do mancal (31) com uma abertura voltada para cima é formado no lado posterior de uma parte superior da estrutura superior (24), e a parte de fechamento (32) que fecha o espaço do mancal (31) quando a tampa (25) é aberta é formado como uma parte inferior do componente do eixo de rotação da tampa (28), sendo a parte inferior mais baixa quando a tampa (25) é aberta.
Patent BR-122012029206-A2 (BR)
Title: Toldo retrátil, e, método de operar um toldo retrátil
Inventor: CUTLER DANIEL
IPC: E04F10/06
Filed: 2008-02-20
Abstract: Toldo retrátil, e, método de operar um toldo retrátil - um toldo compreendendo uma tela (3) que pode ser estendida e retraída, em que é previsto um primeiro motor (20.21) disposto para estender a tela, um segundo motor (35) disposto para retrair a tela e uma unidade de controle (30) disposta para controlar o primeiro e o segundo motores em que o primeiro e o segundo motores são sincronizados de modo a manter a tensão na tela dentro de valores predeterminados.
Patent BR-122017012653-A2 (BR)
Title: método para detecção da densidade celular de cianobactérias e kit para detecção da densidade celular de cianobactérias
Inventor: Catarina Paula da Silva Ramos
IPC: C07K14/195
Filed: 2017-04-19
Abstract: método para detecção da densidade celular de cianobactérias e kit para detecção da densidade celular de cianobactérias a presente invenção descreve um kit e um método de emprego de anticorpos mono ou policlonais dirigidos contra afc1 em ensaios de elisa reverso, o qual é capaz de determinar as densidades de células de cianobactérias em amostras ambientais (água e outras) com eficiência, precisão e praticidade, dispensando a realização de contagens manuais muito mais trabalhosas e imprecisas.
Patent CZ-1299-A3 (CZ)
Title: Novel amidine derivative and its use as thrombin inhibitor
Inventor: ANTONSSON THOMAS
IPC: A61K31/4164
Filed: 1997-06-26
Abstract: There are provided compounds of formula (I), wherein R<1>, R<2>, R<3>, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
Patent SK-3097-A3 (SK)
Title: Muscle tone up device
Inventor: DRUSKA VOJTECH
IPC: A63B21/018
Filed: 1996-05-10
Abstract: A muscle tone up device consisting from a solid frame, weight and from movable actuator, which is connected to a weight with kinematics coupling transmitting through a pull rope the dynamic action of the exercising sportsperson to a changing of the weight stage. The kinematics system contains at least on one side, a two-armed lever (8) fixed during the exercise in a chosen inclination angle, where the main arm (84) is provided with movably set guiding element (87) with a guiding pulley (83) interconnected through a guiding chain (86) with an actuator (4). On the other side, a movable element (2) slidly fits in the guiding (12) on the frame (1) containing a couple of movable pulleys (21), between which the main loop (32) of the pull rope (31) is formed, which is driven through the guiding pulley (83) of the guiding element (87).
Patent CZ-45394-A3 (CZ)
Title: Process for preparing aqueous nicotinaldehyde
Inventor: SIEGRIST URS
IPC: C07D253/00
Filed: 1994-02-28
Abstract: A process for the preparation of an aqueous medium of nicotinaldehyde by the catalytic reduction of 3-cyanopyridine under hydrogen in the presence of Raney-nickel.
Patent CZ-61296-A3 (CZ)
Inventor: STRIZIK STANISLAV
IPC: F41A9/53
Filed: 1996-02-29
Abstract: V závěru 1 pistole je na jejím vnějším horním
povrchu (3) vyústěn otvor (2) přibližně kolmo
k ose (13) hlavně (12) a je veden do komory (4).
V otvoru (2) je suvně uspořádán odpružený
indikační čep (5), který je za přítomnosti náboje
(19) v komoře vysunut jeho obvodovou
částí (17) nad úroveň vnějšího horního povrchu
(3) závěru (1).
Patent CZ-66399-A3 (CZ)
Title: Sewing machine
Inventor: KASTRUP EBERHARD
IPC: D05B39/00
Filed: 1999-02-26
Abstract: An eyelet buttonhole sewing machine has a housing with a stand and an arm. A table for carrying an article being sewn is driven in two mutually perpendicular directions (x, y) on the housing. A clamp for the article being sewn is fastened on the table. A needle bar which is mounted in the arm, is driven so as to move up and down and has a needle at its lower end. The clamp for the article being sewn has two arms fastened on a pedestal connected to the table, each arm having a clamping plate provided to bear on the article being sewn. The fastening points of the two arms on the pedestal are substantially adjacent to one another, and both arms are angled in such a manner that their fastening points are offset to the same side of the longitudinal axis of the arm.
Patent CZ-79798-A3 (CZ)
Title: Process for preparing 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole
Inventor: KVAPIL LUBOMIR RNDR
IPC: C07D233/00
Filed: 1998-03-16
Abstract: In the present invention there is disclosed a process for preparing 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole of the general formula I by reacting 4-amino-5-chloro-2,1,3-benzothiadiazole of the general formula II with  substituted imidazolidine-2-thione of the general formula III by treatment thereof with phosphorus(V) trichloride oxide.
Patent SK-25993-A3 (SK)
Title: Water-soluble camptothecin analogues, process and method
Inventor: FORTUNAK JOSEPH M
IPC: C07D491/22
Filed: 1991-09-23
Abstract: A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.
Patent SK-35894-A3 (SK)
Title: Method of fermentating preparation of l-treonine by cultivation of production strain of escherichia coli 472 t-23
Inventor: PLACHY JIRI
IPC: C12N15/00
Filed: 1994-03-28
Abstract: This invention involves improving the manner of controlling the fermentation of L-threonine, an essential amino acid used in the feed industry and also for pharmaceutical (therapeutic) purposes, by cultivating the production strain Escherichia coli 472 T-23 in a liquid production medium containing common nutriments and additives. The principle of the new procedure, by which a high growth and production speed and a yield of L-threonine of about 80 g/l is achieved with a conversion of saccharose of about 42%, consists of controlling the  agitation and aeration performed according to the value of the pH (6.5 to 7.0) and the content of dissolved oxygen (0.7 to 0.9 mg/l) in the medium, and in the continual addition of a solution of saccharose and ammonia. The novelty of the invention consists of  controlling the fermentation of L-threonine using a concentration of dissolved oxygen which is kept at 0.7 to 0.9 mg/l.
Patent SK-42094-A3 (SK)
Inventor: DVORSKY PAVEL
IPC: B27B7/02
Filed: 1994-04-13
Abstract: Riešenie
sa
týka
spôsobu
a
zariadenia
na
pozdĺžne
spra
­
covanie
drevnej
hmoty
rezom
vo
dvoch
rovinách
pomo
­
cou
pílového
pásu
(2)
upnutého
na
pile
klasickým
spô
­
sobom,
pred
ktorým
je
umiestnený
predrezávaci
kotúč
(1)
na
čistenie
hmoty
od
mechanických
nečistôt.
Pred
pílovým
pásom
(2)
sú
ďalej
na
predĺžených
hriadeľoch
(6,
7)
umiestnené
vertikálne
pílové
kotúče
(10,11).
Kaž
­
dý
hriadeľ
má
samostatnú
pohonnú
jednotku
(8,
9)
a
každá
je
umiestnená
na
samostatnom
suporte,
ktoré
sa
nezávisle
od
seba
pohybujú
v
priečnom
smere
a
spoloč
­
ne
s
pílovým
pásom
(2)
vo
výškovom
smere.
Patent SK-62011-A3 (SK)
Inventor: REJKO PATRIK
IPC: E06B9/56
Filed: 2011-01-25
Abstract: Spôsob
ovládania
horizontálnej
žalúzie,
najmä
okennej,
pri
ktorom
sa
pootočenie
žalúzie
(3)
vykoná
motorizovaným
zariadením
(1),
ktorého
úchyty
(131,
132)
pohybovej
jednotky
(13)
sú
pripevnené
na
slučky
ťahadiel
(21,
22)
ovládača
(2),
pričom
pootvorenie/privretie
žalúzie
(3)
sa
vykoná
pohybom
oboch
úchytov
(131,
132).
Za
­
riadenie
(1)
pritom
obsahuje
elektronickú
riadia
­
cu
jednotku
(11),
ktorá
spracováva
signály
spí
­
nača
(111)
a
zabezpečuje
prostredníctvom
moto
­
ra
(12)
posun
úchytov
(131,
132)
pohybovej
jednotky
(13)
s
upevnenými
ťahadlami
(21,
22)
ovládača
(2)
žalúzie
(3).
Patent CH-609822G-A3 (CH)
Title: Control of exhaust dyeing process
IPC: D06P1/00
Filed: 1976-05-07
Abstract: Dyeing process, which by comparison of time parameters, in particular relaxation times, for the homogenisation process of the dyeing liquor on the one hand and the exhaust process of the dyestuff on the other hand leads to that critical dyeing rate which still just yields an acceptable dyeing.
Patent CZ-151293-A3 (CZ)
Title: Connecting detail for connection of building elements
Inventor: PAPANIKOLAOU DIMITRIS
IPC: E04B1/21
Filed: 1992-11-13
Abstract: A connecting element for connecting construction elements is permanently fixed to one of the units to be connected and can be detachably fixed to at least one other. The connecting element has bridging elements (15, 16, 17) arranged between and at oblique angles to its top and bottom panels (1, 2). Between these bridging elements there is at least one through-aperture extendiny between opposite sides of the top and bottom panels (1, 2). The cross-section of the bridging elements is designed to give them a good rigidity, thus making it possible to increase the size of the apertures while maintaining a high degree of stability, and in particular to improve accessibility to the attachment elements.
Patent CZ-159393-A3 (CZ)
Title: Colored bleaching precursor agent based on a per-acid
Inventor: AGAR JOSEPH THOMAS HENRY
IPC: C07D403/06
Filed: 1992-01-28
Abstract: Solid peroxyacid bleach precursor compositions are provided in which the external surfaces of a particulate peroxyacid precursor material is treated with from 2 % to 20 %  by weight of a solid organic acid compound of Mpt > 30  DEG C and an aqueous solubility of at least 5g/100g water at 20  DEG C. The bleach precursor material, when so treated, perhydrolyses after 3 minutes in a standard test at 20  DEG C, to at least 90 % of the extent of the untreated bleach precursor material under the same conditions. Preferred organic acid compounds are monomeric aliphatic hydroxycarboxylic and polycarboxylic acids such as citric, lactic and glycolic acids. Detergent compositions containing the treated peroxyacid bleach precursor particulates are also disclosed.
Patent CS-331891-A3 (CS)
Title: Film-forming or foil-shaped material comprising crystalline polypropylene polymeric mass
Inventor: KUMAR OGALE ING
IPC: C08L23/16
Filed: 1991-11-01
Abstract: Disclosed is a film or sheet material comprising a blend of (1) a crystalline propylene polymer composition which is comprised of, by weight, (A) from about 30 to 65% of a copolymer of propylene with a C4-8 alpha-olefin containing from 80 to 98% propylene, and (B) 35-70% of a co- or terpolymer of propylene with ethylene and, optionally, a C4-8 alpha-olefin having an ethylene content of 5 to 10% when ethylene is the sole comonomer and an ethylene content of 0.5 to 5% and a C4-8 alpha-olefin content of 1 to 9.5% when both ethylene and a C4-8 alpha-olefin are used as comonomers, and (2) an olefin polymer.
Patent CZ-378292-A3 (CZ)
Inventor: TUMA JOSEF
IPC: B65G47/26
Filed: 1992-12-21
Abstract: Zařízení pro automatické ukládání dýh, zejména od krájecího
stroje, má vedie dopravních pásů (1) lišty (2), spojené se
snímači (3) a pod lištami (2) na plošině umístěn paletovací
vozík (5).
Patent CZ-120297-A3 (CZ)
Title: Process and apparatus for polymerization of alpha olefins in gaseous phase
Inventor: GOVONI GABRIELE
IPC: C08F110/06
Filed: 1996-07-17
Abstract: Process for gas-phase polymerization carried out in two interconnected polymerization zones, to which one or more alpha-olefins CH2=CHR are fed in the presence of catalyst under reaction conditions and from which the polymer product is discharged. The process is characterized in that the growing polymer flows through a first polymerization zone under fast fluidization conditions, leaves said first zone and enters a second polymerization zone through which it flows in a densified form under the action of gravity, leaves said second zone and is reintroduced into the first polymerization zone, thus establishing a circulation of polymer around the two polymerization zones. The novel process allows olefins to be polymerized in the gas phase with high productivity per unit volume of the reactor without incurring the problems of the fluidized-bed technologies of the known state of the art.
Patent CZ-124596-A3 (CZ)
Title: Soil roller with a supporting tube
Inventor: DREYER HEINZ DR DIP ING
IPC: A01B29/04
Filed: 1996-04-30
Abstract: The roller comprises compacting rings (8) spaced apart on the tube (7). At the rear, and below the axis of rotation (10) of the roller scrapers (11) are mounted. These extend between the rings, their working edges (13) being close to or bearing against the tube. The rings can be of wedge-shaped cross-section, and there can be seed guides (5,15) behind the roller, delivering the seeds into the ground or via sowing shares. Seed can be delivered into the grooves left by the rings, each of which can be in two embossed halves.
Patent CZ-146194-A3 (CZ)
Title: Supply tube for delivery of a regulating component in a plasma torch
Inventor: LYNUM STEINAR
IPC: H05H1/26
Filed: 1992-12-11
Abstract: PCT No. PCT/NO92/00198 Sec. 371 Date Aug. 12, 1994 Sec. 102(e) Date Aug. 12, 1994 PCT Filed Dec. 11, 1992 PCT Pub. No. WO93/12634 PCT Pub. Date Jun. 24, 1993.A plasma torch has two or more tubular electrodes located co-axially with one inside the other for chemical treatment of a reactant and includes a lead-in tube supplying the reactant and which is located co-axially in the inner electrode; the lead-in tube includes a liquid-cooled tube provided with a heat-insulating layer on the outer surface; the lead-in tube has a longitudinal axis along which the lead-in tube can be moved for positioning the nozzle at its lower end in relation to the plasma flame; the nozzle end is replaceable and is shaped with a conical wall portion to define a venturi passage to increase the exit velocity of the reactant; between the lead-in tube and the inner electrode an annular passage is provided through which plasma-forming gas is introduced which can be used to cool the reactant gas.
Patent CZ-159899-A3 (CZ)
Inventor: OH NAM H
IPC: A21D8/02
Filed: 1999-05-04
Abstract: Zavlhkapečené těstovinové produkty srychlou kuchyňskou
přípravou, které mají vzhled a strukturu běžných těstovinjsou
částečně předvařeny amají vnitřní porézní strukturu, která
zajišťuje hustotu 0,6 až 1,05 g/ax? a stupeň želatinace 15 až 80 %
Způsob výrobytěchto produktů zahrnuje válcování nebo
extrudování bez vakua nebo zanízkého vakua, následované
pečenímpři teplotě od 82,2 do 176,7 °C na obsah velikosti menší
než 13 %
Patent CZ-195497-A3 (CZ)
Title: 14alpha, 17alpha-c2-bridged derivatives of 19-nor-progesterone, pharmaceutical composition containing thereof and intermediates for their preparation
Inventor: SCHOLLKOPF KLAUS
IPC: A61K31/58
Filed: 1995-12-23
Abstract: The invention concerns 14,17-C2-bridged steroids of general formula (I), wherein: R<3> represents an oxygen atom, the hydroxy amino group or two hydrogen atoms; R<6> represents either a hydrogen, fluorine, chlorine or bromine atom or a C1-C4 alkyl group at the  alpha  or  beta  position, R<6'> and R<7> then representing hydrogen atoms; or alternatively, R<6> represents a hydrogen, fluorine, chlorine or bromine atom or a C1-C4 alkyl group, R<6'> and R<7> then representing a common additional bond; R<7> represents a C1-C4 alkyl group at the  alpha  or  beta  position, R<6> and R<6'> then representing hydrogen atoms; or alternatively R<6> and R<7> together represent a methylene group at the  alpha  or  beta  position and R<6'> represents a hydrogen atom; or R<6> and R<6'> together represent an ethylene or methylene group and R<7> represents a hydrogen atom; R<9> and R<10> each represent a hydrogen atom or a common bond; R<11> and R<12> each represent a hydrogen atom or a common bond; R<13> represents a methyl or ethyl group; R<15> represents a hydrogen atom or a C1-C3 alkyl group; R<16> and R<16'> independently of one another represent a hydrogen atom, a C1-C3 alkyl group, or a C2-C4 alkenyl group, or together represent a C1-C3 alkylidene group; R<15> and R<16> represent a common bond and R<16'> represents a hydrogen atom or a C1-C3 alkyl group, or alternatively R<15> and R<16> together represent a ring of the partial formula (i) shown, in which n = 1 and 2 and X represents a methylene group or an oxygen atom; and R<16'> represents a hydrogen atom; R17<1> represents a hydrogen atom or a C1-C3 alkyl group; R17<2> represents a hydrogen atom, a C1-C3 alkyl group or a C2-C4 alkenyl group; R17<1'> and R17<2'> each represent a hydrogen atom or a common bond; R<21> represents a hydrogen atom or a C1-C3 alkyl group; and R<21'> represents a hydrogen atom, C1-C3 alkyl group or hydroxy group. The claimed compounds do not include 14,17-ethano-19-norpregn-4-en-3,20-dione. The novel compounds, unlike the one disclaimed, show a high level of gestagenic activity even after peroral administration and are suitable for use in the production of medicaments.
Patent CZ-9902036-A3 (CZ)
Title: OB fusion protein composition and methods
Inventor: MANN MICHAEL BENJAMIN
IPC: A61P43/00
Filed: 1997-12-11
Abstract: The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative or analog fused to the N-terminal portion of the OB protein, derivative or analog.
Patent CZ-213193-A3 (CZ)
Title: Apparatus for training dentist's operations and at the same time technical dental works
Inventor: BERLINGHOFF FRANK
IPC: A61C13/00
Filed: 1993-01-21
Abstract: PCT No. PCT/EP93/00134 Sec. 371 Date Oct. 7, 1993 Sec. 102(e) Date Oct. 7, 1993 PCT Filed Jan. 21, 1993 PCT Pub. No. WO93/16458 PCT Pub. Date Aug. 19, 1993.In a training and practice apparatus (1) for simulating and practicing clinical dental processes and for carrying out technical dental work, with a liquid extraction device (17) and a solids extraction device (14), a common vacuum source (25) is provided for both extraction devices (14, 17), with a suction line section (26) which branches at a branch (27) with two suction line branches (28, 29) to the extraction devices (14, 17), a change-over device (37) being arranged in the area of the branch (27) to open the one suction line branch and simultaneously close the other suction line branch (28, 29).
Patent CZ-9902596-A3 (CZ)
Title: Arresting device of one-armed carrier of containers
Inventor: KROUPA BOHUSLAV
IPC: B65G65/23
Filed: 1999-07-22
Abstract: The present invention relates to an arresting device enabling immobilization of a corresponding member (3, 4, 5) of an one-armed container (11) carrier (12) used for both stretching and folding of containers (11) and for folding the containers (11) for the purpose of their emptying. The invented arresting device comprises both an arresting pin (9) intended for fixed connection of a middle member (4) with a rear member (3) and a catch (8) intended for fixed connection of the rear member (3) with a base, optionally with an auxiliary frame (2). The arresting pin (9) is coupled with the catch (8) be means of a shaft (83) having a handle (84) abutting an arm (97) being fixedly coupled with the arresting pin (9).
Patent CZ-286997-A3 (CZ)
Title: Trisubstituted phenyl derivatives, processes of their preparation and pharmaceutical compositions containing such derivatives
Inventor: NUSSBAUMER PETER
IPC: C07D215/233
Filed: 1996-03-14
Abstract: PCT No. PCT/EP96/01116 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 14, 1996 PCT Pub. No. WO96/28430 PCT Pub. Date Sep. 19, 1996The invention concerns compounds of formula I wherein the substituents have various meanings, and their use in the prevention or treatment of inflammatory and proliferative skin diseases and cancer.