baber/WOPTO huggingface dataset:
Patent NZ-726355-A (NZ)
Title: Humanized dipeptidyl peptidase iv (dpp4) animals
Inventor: KYRATSOUS CHRISTOS
IPC: A01K67/027
Filed: 2015-05-28
Abstract: Non-human animals comprising a human or humanized DPP4 nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous Dpp4 gene with a human or humanized DPP4 gene, or non-human animals comprising a human or humanized DPP4 gene in addition to the endogenous Dpp4 gene are described. Non-human animals comprising a human or humanized DPP4 gene under control of human or non-human DPP4 regulatory elements is also provided, including non-human animals that have a replacement of non-human Dpp4-encoding sequence with human DPP4-encoding sequence at an endogenous non-human Dpp4 locus. Non-human animals comprising human or humanized DPP4 gene sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided. Methods for making and using the non-human animals are described.
Patent NZ-730667-A (NZ)
Title: Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
Inventor: CHARPENTIER EMMANUELLE
IPC: C12N15/63
Filed: 2013-03-15
Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
Patent NZ-741114-A (NZ)
Title: Valve coupling having centering support projections
Inventor: PARK YANG
IPC: F16L41/06
Filed: 2016-11-18
Abstract: A pipe network not using valve couplings require two mechanical couplings for each valve in the network, whereas a valve coupling couples a valve directly to pipe elements without the need for multiple mechanical couplings. The present invention provides a valve coupling for joining pipe elements includes a valve housing radially surrounded by coupling segments. Projections extend from the segments and engage channels in the valve housing. Engagement between the projections and the channels guides the segments as they are drawn together to engage the pipe elements and secure the valve housing between the segments. It is advantageous for the valve elements of a valve coupling to be securely and reliably housing within the coupling elements to ensure proper coupling between the pipe elements and proper performance of the valve. It is also advantageous when these are easy to install into the piping network.
Patent NZ-741800-A (NZ)
Title: Wear-resistant multi-layer retractable water pipe
Inventor: SONGLIN DAI
IPC: F16L11/12
Filed: 2018-04-19
Abstract: The present disclosure relates to a wear-resistant multi-layer retractable water pipe, comprising a retractable inner pipe; a one- or multi-layer retractable fabric sleeve; and a retractable wear-resistant protective layer, the retractable inner pipe is nested in the fabric sleeve, and the fabric sleeve is nested in the retractable wear-resistant protective layer; wherein the fabric sleeve is a corrugated sleeve forming a plurality of valleys, which are axially slidable on an outer surface of the inner pipe when the fabric sleeve is deployed or retracted. The present disclosure has the following advantages: the pressure bearing capacity of the water pipe is improved; and the service life of the water pipe is prolonged for the contacting area of the corrugated fabric sleeve with the inner pipe is small and thus generates a low axial frictional force onto the outer surface of the inner pipe, so that the damage to the inner pipe caused by the friction is reduced.
Patent NZ-758970-A (NZ)
Title: Compositions and methods for producing genetically modified animals
Inventor: KOENTGEN FRANK
IPC: A01K67/027
Filed: 2014-11-07
Abstract: Methods, compositions and non-human animals and parts thereof are disclosed for improving germ line transmission of genetic modifications. More particular, the present invention discloses methods and compositions for producing non-human embryos with a disrupted or disruptable fertility gene, which can be used as hosts for the development of donor pluripotent cells, including genetically modified donor pluripotent cells, into germ cells and gametes. Also disclosed are methods and compositions for producing from such embryos chimeric non-human animals with a disrupted fertility gene and for breeding the chimeric non-human animals with cognate non-human animals that comprise a fertility gene that lacks a disruption to produce non-human animals having substantially all gametes and/or germ cells derived from the donor pluripotent cells. The present invention also discloses non-human gametes, germ cells, embryos and animals for use in the subject methods.
Patent NZ-763766-A (NZ)
Title: Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
Inventor: ERICSSON ANNA
IPC: C07D487/04
Filed: 2018-03-20
Abstract: The disclosure relates to modulating pyruvate kinase and provides chemical compound 1 useful as an activator of PKR, as well as various uses of this compound. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
Patent PT-100400-A (PT)
Inventor: OWEN ALBERT J
IPC: A61K47/14
Filed: 1992-04-16
Abstract: There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.
Patent PT-103741-A (PT)
Title: Sistema multiplicador e orientador de forças
Inventor: SOUSA LUIS ALVARES MARTINS DE PAIVA E
IPC: F16H1/02
Filed: 2007-05-15
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM DISPOSITIVO MULTIPLICADOR E ORIENTADOR DE FORÇAS QUE PODE SER LIGADO, EM QUALQUER POSIÇÃO, A UM MOTOR 25 QUE UTILIZE QUALQUER FONTE DE ENERGIA E QUE TRANSMITIRÁ ATRAVÉS DO SEU EIXO 26 A ENERGIA NECESSÁRIA PARA O DISPOSITIVO RODAR EM TORNO DO EIXO DO MOTOR, PERMITINDO AO UTILIZADOR ESCOLHER A DIRECÇÃO E O SENTIDO DO DESLOCAMENTO DO DISPOSITIVO E DO MOTOR LIGADO AO DISPOSITIVO, ATRAVÉS DA HASTE 24. O DITO DISPOSITIVO COMPREENDE DOIS DISCOS, LIGADOS ENTRE SI, COMQUATRO PESOS 11 NO INTERVALO ENTRE ELES, ORIENTADOS NA MESMA DIRECÇÃO. OS DITOS PESOS PERMANECEM NA MESMA DIRECÇÃO EM SIMULTÂNEO, DURANTE A ROTAÇÃO DOS DITOS DISCOS, POR MEIO DE NOVE RODAS DENTADAS QUE ESTÃO TODAS LIGADAS ENTRE SI E À FIXAÇÃO DOS QUATRO PESOS. AS DITAS RODAS DENTADAS PODEM SER CONTROLADAS POR MEIO DE UMA MANIVELA, INSTALADA NA RODA DENTADA CENTRAL, QUE PERMITE CONTROLAR A DIRECÇÃO QUE TODOS OS PESOS TOMAM EM SIMULTÂNEO E ESCOLHER A DIRECÇÃO PARA A QUAL TODO O SISTEMA SE VAI DIRIGIR.
Patent PT-109939-A (PT)
Title: Equipamento para furação de papel com sistema de ajuste, método de inserção e remoção do acessório de furação e método de furação
Inventor: ESPERANÇA CELESTE RESCOVA
IPC: B26F1/16
Filed: 2017-03-01
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM EQUIPAMENTO PARA FURAÇÃO DE PAPEL, MAIS ESPECIFICAMENTE A UM FURADOR DE PAPEL COM ACESSÓRIOS DE FURAÇÃO CAMBIÁVEIS, COM PUNÇÕES DE FURAÇÃO AJUSTÁVEIS, E AO MÉTODO DE TROCA DO ACESSÓRIO DE FURAÇÃO. O EQUIPAMENTO É CONSTITUÍDO PELA CAIXA (1), ALAVANCA (1.12), ACESSÓRIO DE FURAÇÃO (2), BLOCO DE PRESSÃO (3), SISTEMA DE AJUSTE (6), SUPORTE VERTICAL (7) E ARMAÇÃO (8).
Patent PT-110728-A (PT)
Title: Sistema de controlo do processo industrial de tingimento de fibras têxteis por esgotamento
Inventor: JOÃO MANUEL FERNANDES BAÍA
IPC: D06B3/10
Filed: 2018-05-09
Abstract: NO PROCESSO DE TINGIMENTO (OU COLORAÇÃO) DE FIBRAS TÊXTEIS POR ESGOTAMENTO, OS CORANTES NÃO SÃO ADICIONADOS DIRETAMENTE NA MATÉRIA-PRIMA, SÃO DISSOLVIDOS OU DISPERSOS NUM BANHO AQUOSO ONDE A MATÉRIA - PRIMA É SUBMERSA SOB AGITAÇÃO VIGOROSA, AQUECIMENTO E ADIÇÃO DE PRODUTOS QUÍMICOS. DURANTE O PROCESSO, UMA PARTE DO CORANTE DIFUNDE-SE ATRAVÉS DO BANHO, CONTACTA E LIGA - SE, QUÍMICA OU FISICAMENTE, ÀS FIBRAS TÊXTEIS QUE CONSTITUEM A MATÉRIAPRIMA, OUTRA PARTE DO CORANTE PERMANECE NO BANHO. A COR QUE SE VAI OBTER SERÀ O RESULTADO DO CORANTE EFETIVAMENTE LIGADO À FIBRA. DURANTE O PROCESSO DE COLORAÇÃO, EXISTEM SEMPRE FATORES DE DIFÍCIL OU INVIÁVEL CONTROLO, QUE FAZEM COM QUE A COR FINAL SE AFASTE DA COR PREVISTA. INICIADO O PROCESSO DE TINGIMENTO, SÓ DEPOIS DE TERMINADO, COM A LAVAGEM E A SECAGEM DA MATÉRIA- PRIMA É QUE SE CONSEGUE VER A COR OBTIDA. SE ESTIVER DESVIADA, COMO É FREQUENTE, SÓ RESTA O REPROCESSAMENTO E EM CASOS EXTREMOS HÁ A PERDA DA MATÉRIAPRIMA, EM QUALQUER DAS CIRCUNSTÂNCIAS OS CUSTOS SÃO MUITO ELEVADOS. O PRESENTE INVENTO CONSISTE, ATRAVÉS DA MEDIÇÃO DO BANHO DE TINGIMENTO AO LONGO DO PROCESSO, MONITORIZAR EM TEMPO REAL A CONCENTRAÇÃO DE CORANTE NO BANHO, DETERMINAR O ESGOTAMENTO DO CORANTE, DETERMINAR O CORANTE LIGADO À FIBRA PERMITINDO PREVER SE A COR VAI NO SENTIDO DA COR PRETENDIDA E, CASO NÃO VÁ CORRIGIR ANTECIPADAMENTE .
Patent RU-94013106-A (RU)
Inventor: CHURJUMOV V A
IPC: B02C17/18
Filed: 1994-04-12
Abstract: FIELD: manufacture of building materials. SUBSTANCE: grate has stationary bars interconnected by guideways with movable bars disposed in them. Movable bars can have smaller cross-section, can be disposed closer to fine grinding chamber, can have different shape, and be located perpendicular to diameter, radius or may be bent according to radii. EFFECT: enhanced slot self-purifying.
Patent RU-94014712-A (RU)
Inventor: ORININSKIJ N V
IPC: B28B1/54
Filed: 1994-04-20
Abstract: FIELD: metallurgy; processing of large-tonnage molten early slags with manufacture of large-sized articles, having a close porous structure. SUBSTANCE: plant uses a mixer, vibrating chute, water-cooled rolls and a moulding machine; a water-cooled burner, funnelled opening and a shield are installed under the rolls; and the machine with moulds is to be found under the burner. EFFECT: enhanced capacity.
Patent RU-94025225-A (RU)
Inventor: OL GARENKO V I
IPC: E02B11/00
Filed: 1994-07-05
Abstract: FIELD: melioration, drainage systems, specifically, drain wells. SUBSTANCE: settling tank is placed in the drain well. Hollow chamber is attached to the top of the settling tank. A pipe is placed in the center of the settling tank. EFFECT: high efficiency.
Patent RU-94027789-A (RU)
Inventor: VERTINSKIJ A P
IPC: C02F103/16
Filed: 1994-07-25
Abstract: FIELD: chemical engineering. SUBSTANCE: electrocoagulator consists of housing with conical bottom, connecting pipes for waste water feed, derivation of purified water and slime discharge. Inductors are placed inside housing on fastening bolts. Each single-phase inductor consists of core of toroidal shape on which single-phase winding of bare wire with large electrical resistance, Nichrome for example, is made with the aid of insulating ring-shaped gaskets by tappings through insulating locks in cover. When power supply is switched on, primary current goes along windings heating them and inducing secondary current in electrolyte. Slime is formed as a result of electrocoagulation. Under action of gravity the slime precipitates on conical bottom of housing and is discharged through corresponding connecting pipe. Current supply is made in the form of toroidal inductors with primary single-phase windings of bare high-resistance wire. EFFECT: enhanced efficiency of cleaning waste water containing ions of hard metals.
Patent RU-94028805-A (RU)
Inventor: APTEKAR N M
IPC: B22D19/16
Filed: 1994-08-01
Abstract: FIELD: metallurgy, namely improved manufacturing process of casting ingots for making laminate rolled stock. SUBSTANCE: method of casting ingots with directional crystallization and homogeneous structure and texture along their cross section providing crystallographic plane 100 parallel with wall of ingot mold comprises steps of initial casting to mold base metal, subsequent after-casting metal has been heated by 50-56 C lower than base metal heating temperature. EFFECT: enhanced quality of ingots.
Patent RU-94029110-A (RU)
Inventor: GRACHEV P A
IPC: A23B4/052
Filed: 1994-08-02
Abstract: FIELD: food-processing engineering. SUBSTANCE: smoke generator has bypass device positioned below water jacket and metering device. Bypass device has diaphragm and at least one heat-reflecting screen positioned for moving one with respect to the other so that gaseous smoke generation products exit passages are defined. Heat-reflecting screen is positioned in opposed relation with respect to diaphragm passages so that labyrinths are defined between passages. Cleaning chamber is positioned outside housing and is provided with adapter pipe, which is mounted above adapter pipe. Smoke ducts are connected with water jacket through overflow pipelines and provided with devices for uniform water distribution over their inner surfaces. EFFECT: increased efficiency, stabilized process, improved quality of smoke-air mixture, reduced fire danger. 5 cl, 5 dwg
Patent RU-94030563-A (RU)
Inventor: LARIONOV G V
IPC: B62D33/077
Filed: 1994-08-17
Abstract: FIELD: transport; trackless vehicles. SUBSTANCE: specialized vehicle can be easily converted from dump truck into load truck with rigid fastening of body on frame and locking of hydraulic dumping gear This is provided by use of one or more grips connected with locking mechanism of one of truck sides, for instance with tailgate locking mechanism, to rigidly couple body with chassis frame when tailgate is locked and use of dumping gear hydraulic interlock mechanism coupled with high and low pressure lines of device. Control of hydraulic interlock mechanism is coupled with grip and tailgate lock mechanism and, with tailgate locked, blocks delivery of liquid under pressure to hydraulic power members. EFFECT: improved design of dump truck bodies and dumping gears. 2 cl, 4 dwg
Patent RU-94038272-A (RU)
Inventor: SHAROV V V
IPC: F01C1/00
Filed: 1994-09-27
Abstract: FIELD: drives of actuating mechanisms. SUBSTANCE: motor has impeller with blades; on one side of each blade bellows with weights (floats) are secured for forcing the gas out of one half of impeller to its other half through respective air ducts due to gravity force. Motor may be used for operation both in water and air media (in last case, bellows are filled with light gas, helium, for example). EFFECT: enhanced reliability. 1 dwg
Patent RU-94040455-A (RU)
Inventor: KULINICH A P
IPC: C04B7/52
Filed: 1994-11-04
Abstract: FIELD: manufacture of building materials. SUBSTANCE: expanding cement additive is prepared from aluminium, lime, and gypsum-containing components, namely, wt. -%: bauxite or kaoline clay, 22-46; waste dolomite dust, 4-8; gypsum- containing sludges from neutralization of hydrolysis acid in titanium dioxide production, 30-40; and wastes from acetylene production or dust caught in limestone calcination process, 20-30. EFFECT: reduced power consumption and raw material cost.
Patent RU-94042212-A (RU)
Inventor: D JACHKOV A N
IPC: A61B17/56
Filed: 1994-11-24
Abstract: FIELD: experimental surgery; elaboration of methods for replacement of defects of skull vault. SUBSTANCE: through incision of soft tissues, splitting off of bone by size of defect beyond the defect zone is effected. With use of Ilizarov apparatus, split-off bone is moved and regenerate is formed. Transplant is cut out from regenerate, and defect is closed with transplant. EFFECT: provision of covering of skull vault defect with regenerate formed beyond the zone of defect. 2 cl
Patent RU-94044355-A (RU)
Inventor: IBALDUS FRANSISKUS KRAGTEN
IPC: C07C45/53
Filed: 1994-12-22
Abstract: FIELD: chemical industry. SUBSTANCE: process for preparing alkanone and/or alkanol by oxidizing alkane and/or alkene having from 6 to 30 carbon atoms, with oxygen to form alkylhydroperoxide, followed by decomposition of the resulting alkylhydroperoxide in the presence of catalyst comprising metal compound placed on carrier material is carried out in the presence of separated aqueous phase with pH higher than 8.5, and the catalyst metal is selected from group consisting of Mn, Fe, Co, Ni and Cu and the carrier material is stable in the presence of aqueous alkali phase. EFFECT: more efficient preparation process.
Patent RU-95104279-A (RU)
Inventor: MAL CHIKOV G D
IPC: B01J27/10
Filed: 1995-03-23
Abstract: FIELD: catalysts for organic syntheses. SUBSTANCE: nickel catalyst for hydrogenation of unsaturated and aromatic hydrocarbons, in particular, benzyl cyanide is prepared by way of reducing alkali solution with pH 13-14 containing 25-100 g/l nickel chloride and 125-500 g/l hydrazine hydrate. Process is conducted at ambient temperature for 10-20 min, whereupon obtained powder is washed using decantation and dried. EFFECT: improved preparation procedure. 2 cl
Patent RU-95107360-A (RU)
Inventor: KOLESNICHENKO S V
IPC: F41G7/22
Filed: 1995-05-06
Abstract: FIELD: control systems of pilotless aircraft having a ballistic trajectory; flight vehicles penetrating the hitting areas of antiaircraft missile complexes for suppression of automatic tracking after their detection by radar aids. SUBSTANCE: a device is introduced in the design of the flight vehicle providing for an abrupt decrease of the effective reflecting surface and introduction of jamming to the radar aids of the antiaircraft missile complex. Use is made of a device providing for identification of the moment of lock-on and abrupt dynamic action on the tracking circuit over the legitimate and target channels. Realization of the device does not cause any principle difficulties, since the practice of production of the main components is well developed by industry. EFFECT: enhanced probability of penetration of heating area of the antiaircraft missile complex by the flight vehicle due to introduction of a complex disturbance to the tracking circuit resulting in a suppression of the process of automatic tracking of the flight vehicle as a target.
Patent RU-95109982-A (RU)
Inventor: PETROV JU I
IPC: F02P15/10
Filed: 1995-06-14
Abstract: FIELD: mechanical engineering; internal combustion engines; igniting of lean fuel mixtures. SUBSTANCE: thyristor-plasma ignition system for internal combustion engines has ignition coil. First terminal of coil secondary winding is connected through distributor with first terminals of spark plug group whose second terminals are connected to common bus. System has twin voltage converter. First output source of converter is connected by one pole to anode of thyristor switch and to series-connected reservoir capacitor and first terminal of ignition coil primary winding and second output source is connected by second pole to common bus. Pulse shaper of system is connected by input to breaker contact and by output, to control input of thyristor switch. To solve the problem, second pole of first output source, second terminal of ignition coil primary winding and second terminal of thyristor switch are connected to common bus and second terminal of ignition coil secondary winding is connected to first pole of second output source of voltage converter. Expenses are brought to minimum owing to fundamentally new approach to building of circuit at which resistive decoupling between main elements and common bus is not required, there is no constant voltage component across ignition coil primary winding and restoring element and voltage switch are not required. EFFECT: minimized expenses.
Patent RU-95110356-A (RU)
Inventor: KVASENKOV O I
IPC: C11B9/02
Filed: 1995-06-21
Abstract: FIELD: food industry, particularly, recovery of food fats and essential oils from vegetable raw materials. SUBSTANCE: claimed method comprises mixing vegetable raw material and non-polar extracting agent, treating extraction mixture with ionizing irradiation dose from 300 to 800 krad per 1 kg of raw material during sonification with extracting agent vapors condensed therein, separating micelle from oil cake, removing extracting agent vapors from micelle to obtain the desired product and bubbling separated extracting agent vapors into extraction mixture for condensation purposes. EFFECT:
Patent RU-95111179-A (RU)
Inventor: MERTSALOV L A
IPC: A23L3/02
Filed: 1995-06-28
Abstract: FIELD: food engineering, in particular, equipment for thermal treatment of liquid products, for instance milk, in small enterprises and farms. SUBSTANCE: tank has heat-insulated container with water jacket, electric mixer, level relay, resistance thermometer, electromagnetic valve, cabinet with electric equipment, in particular, temperature-control device, time relay, mode selection switch, switching and signaling apparatus. Sensitive member 10 of level relay is mounted in upper part of water jacket cavity. Tank has tubular electric heaters inserted into water jacket cavity through detachable flanges 11 of lower bottom. Electric heaters are connected one with another and with power mains through starter in cabinet. Starter coil is connected in series with contact of temperature-control device which is disengaged, when predetermined temperature is established, and with level relay contact , which is closed, when predetermined amount of water is in water jacket cavity. Circuit including in series connected time relay and closing time-independent contact of this relay, connected in parallel with disengaging contact of starter, is connected in parallel with mentioned circuit having starter coil and disengaging contact of temperature-control device, which are connected in series. Tank allows thermal treatment of liquid products to be used in enterprises deprived of steam supply system. EFFECT: increased efficiency, simplified construction and improved quality of treated product. 1 dwg
Patent TW-200407092-A (TW)
Title: Assembly coaster
Inventor: CHEN CHENG-HSIUNG
Filed: 2002-11-12
Abstract: A coaster includes an outer edge, a male connector, and a female connector. The male connector set on a first end of the outer edge for engaging with a female connector of another coaster. The female connector set on a second end of the outer edge for engaging with a male connector of another coaster. After connecting the coaster with other coasters, the plurality of coasters can form a supporting pad for supporting a container with large bottom surface.
Patent TW-200306546-A (TW)
Title: Information recording medium, information recording and /or reproducing apparatus and method, and computer program
Inventor: KANEGAE TOHRU
IPC: H04N5/92
Filed: 2003-01-17
Abstract: An information recording medium is provided with: an object data file for storing object data which constitutes a series of content information, such as picture information and audio information, and a play list information file for storing play list information which defines a reproduction sequence of the object data by a unit of a play list. The information recording medium is further provided with a disc information file for storing a plurality of title play lists including, (i) play list specification information for specifying the play list information which defines the play list to be reproduced, (ii) pre command information, and (iii) post command information, which indicate a command to be executed before and after the reproduction, respectively, based on the play list information.