baber/WOPTO huggingface dataset:
Patent AU-726406-B2 (AU)
Title: Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof
Inventor: LAWRENCE DANIEL A
IPC: A61K38/00
Filed: 1997-04-11
Granted: 2000-11-09
Abstract: Mutants of the human PAI-1 protein are described which are inhibitors of neutrophil elastase or are inhibitors of vitronectin (Vn)-dependent cell migration. These mutants preferably comprise one or two amino acid substitutions in the reactive center loop of PAI-1, particularly at positions 331 and 346 of the mature protein. These mutants are notable in being resistant to inactivation by elastase, having high affinity for Vn, or both properties. These mutant proteins as pharmaceutical compositions are used to inhibit elastase in a subject, thereby treating a number of disorders associated with elastase activity, most notably emphysema, ARDS, inflammatory lung injury and cystic fibrosis. The mutants which interact with Vn are used to inhibit cell migration in a subject, thereby treating diseases or conditions associated with undesired cell migration and proliferation, particularly of smooth muscle cells. Such conditions include atherosclerosis, post angioplasty restenosis, fibrosis associated with chronic inflammation or chemotherapy, tumor invasion and metastasis and conditions in which angiogenesis is pathogenic. Also disclosed are peptides of such mutant proteins, mutant-specific antibodies, nucleic acid molecules, particularly DNA, encoding the mutant protein and host cells transformed by such nucleic acids.
Patent AU-772670-B2 (AU)
Title: Anti-cancer dihydroquinazoline derivatives
Inventor: SKELTON LORRAINE
IPC: A61P35/00
Filed: 2000-02-24
Granted: 2004-05-06
Abstract: Dihydroquinazoline derivatives of the formulawhere R3 is -(CH2)p-A where p is from 1 to 4 and A is a 5- or 6-membered N-containing heterocyclic ring attached via the N atom or A is -NA'A'' wherein A' and A'' are the same or different and are each a C1-C4 alkyl group or their pharmaceutically acceptable salts possessing anti-cancer activity.
Patent AU-624347-B2 (AU)
Title: Surround-sound system
Inventor: HOLMAN TOMLINSON
IPC: H04S5/00
Filed: 1989-01-06
Granted: 1992-06-11
Abstract: Spectral imbalance (alteration in timbre) when playing home video versions of motion pictures is overcome by re-equalization according to a unique correction response curve which compensates for the equalization for playback in large theater-sized auditoriums inherent in motion picture soundtracks. Surround-sound home playback of motion pictures is enhanced by employing main channel loudspeakers that produce generally direct sound fields and surround channel loudspeakers that produce generally diffuse sound fields. Preferably, further equalization is applied to the reproduced surround channel to compensate for the differences in perceived timbre between direct and diffuse sound fields. In addition, the reproduced surround-sound channel is further enhanced by decreasing the interaural cross-correlation of the surround-sound channel sound field at listening positions within the room, preferably by introducing slight pitch shifting in the signals applied to multiple surround loudspeakers.
Patent AU-604400-B2 (AU)
Title: Multiple delivery system
Inventor: SMITH DAVID A
IPC: B65H3/10
Filed: 1989-02-22
Granted: 1990-12-13
Abstract: A high speed product delivery system is provided which delivers individual flexible web products from a product drum to a plurality of transfer drums. The transfer drums, in turn, deliver products to further transfer drums or to packaging devices. The system permits increases in the production rate of the products without increasing the demand on the packaging devices.
Patent AU-695350-B2 (AU)
Title: Fractionated polydisperse compositions
Inventor: SMITS GEORGES
IPC: A23L9/10
Filed: 1995-07-07
Granted: 1998-08-13
Abstract: The present invention concerns a new fractionated polydisperse carbohydrate composition having the following definition: an av. DP which is significantly higher than the av. DP of a native polydisperse carbohydrate composition, significantly free of low molecular monomers, dimers, and oligomers, significantly free of impurities chosen among the group consisting of colourings, salts, proteins and organic acids, significantly free of technological aids such as solubility affecting products. The present invention concerns also the preparation process of the composition according to the invention.
Patent AU-694904-B2 (AU)
Title: Preparations of particles for linings for pipelines and passageways
Inventor: CHANDLER BRIAN BURNETT
IPC: B01J2/18
Filed: 1997-08-18
Granted: 1998-07-30
Abstract: The invention provides that particles are prepared for use in curable synthetic resin which can be cured selectively. The particles are prepared by filling the curing agent into micropores of the particles using sonic, preferably ultrasonic, energy, and then the particles are dispersed throughout the resin. The curing agent is only released when the resin is subjected to applied energy such as sonic and/or heat energy.
Patent AU-629833-B2 (AU)
Title: Colorimetric assay of 2-bromo-2-nitro-1,3-propanediol or derivatives thereof
Inventor: HILL MARTYN WILLIAM
IPC: G01N31/22
Filed: 1989-05-11
Granted: 1992-10-15
Abstract: A method for assaying Bronopol or Permachem, i.e. 2-bromo-2-nitro-1,3-propanediol or 2,2-dibromo-2-nitroethanol, or a derivative thereof in a sample, comprises adding to the sample a diazo compound which reacts with the compound under test to form a colored species, and determining the presence and, if desired, concentration of the species colorimetrically.
Patent AU-614632-B2 (AU)
Title: Press-fit electrical terminal
Inventor: THOMASSEN EGIDIUS THEODORUS RE
IPC: H01R12/58
Filed: 1989-06-20
Granted: 1991-09-05
Abstract: An electrical contact terminal having a mounting section designed for press-fit insertion into a hole of a substrate such as a circuit board. The mounting section comprises an oblong base portion to which is secured at least one separately formed flexible fin. While the base portion and fin are both electrically conductive, they are not formed integrally from the same material and may be formed of two different materials. The fin or fins are secured to opposite sides of said base portion and are secured to said base portion at one or both ends. At one end, the fins are narrowed in width and thickness and secured to the base portion by means of electrical or laser welding. The fins may be mechanically clamped to the base portion at the other end. The terminals may be carried by a carrier strip and the fins may be preferably formed by punching a portion of said carrrier strip and bending it around said base portion of the terminal to form parallel fins extending on opposite lateral sides of the base portion. A process for manufacturing the electrical terminal is also disclosed.
Patent AU-738514-B2 (AU)
Title: Periadventitial delivery device
Inventor: MARTIN JOHN FRANCIS
IPC: A61K38/19
Filed: 1999-04-28
Granted: 2001-09-20
Abstract: A biodegradable matrix material is provided in a form that can be wrapped around a body part, in combination or impregnated with an agent that can be delivered to treat a condition via the adventitial surface of a body part, the agent being in a form that can be taken up by the matrix material. These components are provided for use in the treatment of the condition, e.g. by using a sealant to form a seal around the matrix material when impregnated with the agent.
Patent AU-686896-B2 (AU)
Title: Diaminocyclobutene-3,4-diones
Inventor: ANTANE MADELENE MIYOKO
IPC: A61K31/135
Filed: 1995-10-03
Granted: 1998-02-12
Abstract: The compound of formula (I), wherein R1 and R2 are, independent from each other, hydrogen, C1-10 straight chain alkyl, C1-10 branched alkyl, or C3-10 cyclic or bicyclic alkyl; R3 is an acyl substituent selected from the group consisting of formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms; A is selected from the group consisting of (a), wherein R4 is hydrogen, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-6 alkylamino, C2-12 dialkylamino, C1-6 alkylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, nitro, cyano, carboxyl; or, A is a phenyl group of formula (b), wherein R5 and R6, independent from each other, are selected from the following: cyano, nitro, amino, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, C1-6 alkylamino, C2-12 dialkylamino, sulfamyl, C1-6 alkylsulfonamido, C6-12 arylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, arylcarboxamido containing 7 to 13 carbon atoms, C2 to C6 alkanoyl, C1-6 alkylsulfonyl, C1-6 perfluoroalkylsulfonyl, C6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.
Patent AU-701033-B2 (AU)
Title: Method and anastomotic instrument for use when performing an end-to-side anastomosis
Inventor: RYGAARD JORGEN A
IPC: A61B/
Filed: 1995-10-31
Granted: 1999-01-21
Abstract: PCT No. PCT/DK95/00430 Sec. 371 Date Sep. 17, 1998 Sec. 102(e) Date Sep. 17, 1998 PCT Filed Oct. 31, 1995 PCT Pub. No. WO97/16122 PCT Pub. Date May 9, 1997When performing an end-to-side anastomosis connecting the end of a first vessel to the edge region around an opening in the side wall of a second vessel, an instrument is used having a circumferential stapling anvil secured to an anvil tube accommodating the first vessel, the end of which is everted about the anvil with the intima of the end region facing the intima of the edge region, when the instrument with the first vessel in place has been inserted into the opening in the second vessel. Then, a clamping tube is advanced towards the anvil, clamping the end and edge region together against the anvil. In the next step, a number of stapling plungers carrying staples are advanced towards the anvil, the latter having staple-bending surfaces, thus stapling the two vessels together in a manner not shown. Finally, the clamping tube and the stapling plungers are withdrawn, and the whole instrument removed from the anastomosis.
Patent AU-627200-B2 (AU)
Title: Liquid spray application of coatings with supercritical fluids as diluents and spraying from an orifice
Inventor: HOY KENNETH LOOK
IPC: C09D7/00
Filed: 1989-07-13
Granted: 1992-08-20
Abstract: A liquid coatings application process and apparatus is provided in which supercritical fluids, such as supercritical carbon dioxide fluid, are used to reduce to application consistency viscous coatings compositions to allow for their application as liquid sprays. The coatings compositions are sprayed by passing the composition under pressure through an orifice into the environment of the substrate.
Patent AU-580050-B2 (AU)
Title: Triazolopyrimidine derivatives
Inventor: ISODA SUMIRO
IPC: C07D417/04
Filed: 1985-04-24
Granted: 1988-12-22
Abstract: Novel triazolopyrimidine compounds represented by the formula (I) and physiologically acceptable salts thereof are disclosed. These compounds have an excellent antial- lergic activity in oral administration and are useful for treatment and prophylaxis of allergic diseases such as bronchial asthma, allergic gastro-intestinal disorders, allergic rhinitis, hay fever, urticaria and the like.
Patent AU-620457-B2 (AU)
Title: Improvements in or relating to the recovery of silver
Inventor: WATKISS PHILIP JOHN
IPC: C22B3/00
Filed: 1989-10-19
Granted: 1992-02-20
Abstract: In a method of recovering silver from an aqueous suspension, the suspension is admixed with a solution capable of converting silver halide to metallic silver to cause flocculation of the silver, the flocculated silver is separated from the aqueous phase, and the silver is recovered.
Patent AU-634985-B2 (AU)
Title: Method and reagents for detecting amphetamine and/or d-methamphetamine in biological samples
IPC: C07D311/90
Filed: 1989-10-26
Granted: 1993-03-11
Abstract: This disclosure relates to a method and reagents for determining amphetamine and d-methamphetamine in a biological fluid, such as urine. In particular, this disclosure relates to improvements in a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and d-methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as  beta -hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH, and contacting the sample with riboflavin binding protein to reduce interference from fluorescent components in the sample. The procedure also maintains the cross reactivity of the immunoassay for tyramine at about 0.4% and for l-methamphetamine below about 5.1% and eliminates the necessity of using controlled substances as starting materials.
Patent AU-664641-B2 (AU)
Title: Dual-chamber injection cartridge
Inventor: LJUNGQUIST OLLE
IPC: A61M5/28
Filed: 1993-06-23
Granted: 1995-11-23
Abstract: PCT No. PCT/SE93/00558 Sec. 371 Date Feb. 24, 1994 Sec. 102(e) Date Feb. 24, 1994 PCT Filed Jun. 23, 1993 PCT Pub. No. WO94/01150 PCT Pub. Date Jan. 20, 1994.A method for manufacturing an injectable preparation of a pharmaceutically active agent suitable for storage in a dual-chamber injection cartridge. A dual chamber injection cartridge is provided, including: a barrel; a front chamber for a solid component; a rear chamber for a liquid component; a displaceable front piston separating the front and rear chambers; a closure sealing the front end of the barrel; and a constriction between the front and rear ends of the barrel. The constriction has a non-circular cross-section and an openable bypass connection permitting passage of liquid between the rear and front chambers. Prior to opening the bypass connection, the front piston is positioned between the constriction and the rear end of the barrel. The constriction resists displacement of the front piston in a direction of the front end of the barrel when the piston is in the vicinity of the constriction. The constriction prevents displacement of the front piston toward the front end of the barrel when a vacuum exists in the front chamber. A pressure in the vicinity of atmospheric pressure exists in the rear chamber. The front piston is deformed while being displaced through the constriction in the direction of the front end of the barrel while overcoming the resistance. The deformation establishes the liquid bypass connection. The rear chamber is filled with the liquid component. The rear chamber is sealed. A solution of the pharmaceutically active agent is charged in the front chamber. The front chamber is sealed.
Patent AU-626608-B2 (AU)
Title: A process for the preparation of tripeptides
Inventor: FLEMMING HANS-WOLFRAM
IPC: C07K1/08
Filed: 1989-11-21
Granted: 1992-08-06
Abstract: Process for preparing tripeptides of the general formula I  U-A-B-C-OH   I in which U is hydrogen or a urethane protective group and A, B and C are amino acids, by reacting a compound of the general formula II  U'-B-OH   II in which U' is a urethane protective group which can be eliminated by hydrogenolysis, with a compound of the general formula III  H-C-OR   III in which R is alkyl, by the PPA method, eliminating U', reacting the compound obtained in this way with a compound of the general formula IV  H-B-C-OR   IV by the PPA method and subsequently eliminating R enzymatically.
Patent AU-666215-B2 (AU)
Title: Repulping paper and paperboard
Inventor: ESPY HERBERT H
IPC: D21C3/00
Filed: 1993-09-03
Granted: 1996-02-01
Abstract: A composition for repulping a cellulose fiber paper broke in an aqueous slurry comprising a mixture of a non-chlorinating oxidizing agent and a water-soluble buffering salt that is capable of maintaining the Ph between about 7 and about 12 in the reaction mixture of the wet-strength broke and the oxidizing agent, the use of the composition in a process for repulping the paper broke, particularly for repulping paper containing wet strength resins, and the process for repulping the paper broke.
Patent AU-763731-B2 (AU)
Title: Hydrochloride of fused-heterocycle compound
Inventor: FUJITA TAKASHI
IPC: A61P3/10
Filed: 2000-05-24
Granted: 2003-07-31
Abstract: The present invention concerns the hydrochloride of the compound (5-Ä4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzylÜthiazolid in-2,4-dione) of the following structure (I) which exhibits an excellent hypoglycemic activity and the like. <CHEM>
Patent AU-589939-B2 (AU)
Title: Medical composition for injection containing a spergualin as active ingredient and process for preparing the same
Inventor: UMEZAWA HAMAO
IPC: A61K31/16
Filed: 1986-01-13
Granted: 1989-10-26
Abstract: The present invention relates to pharmaceutical compositions containing Spergualins or salts thereof useful as cancer control agents and immunomodulators which are stabilized by addition of at least one member selected from the group consisting of mannitol, maltose, dextran, lactose, cyclodextrin, gelatin, chondroitin sulfate and human serum albumin.
Patent AU-744750-B2 (AU)
Title: Wound healing and treatment of fibrosis
Inventor: FERGUSON MARK WILLIAM JAMES
IPC: A61K48/00
Filed: 1997-12-04
Granted: 2002-02-28
Abstract: Compositions for use in the treatment of wounds and fibrosis comprising a therapeutically effective amount of a compound that modulates actin assembly and organization intracellularly and/or extracellularly and a pharmaceutically acceptable vehicle; such a compound promotes the rate of wound healing and also prevents or reduces fibrosis. A preferred compound is gelsolin.
Patent AU-589607-B2 (AU)
Title: Electrical heating system for a bimetal, particularly for an electrical power control device
Inventor: ESSIG WILLI
IPC: H01H37/00
Filed: 1986-03-07
Granted: 1989-10-19
Abstract: A power control includes a thick film resistor on an electrically insulating support plate, for heating a bimetal strip operating switch contacts connecting power to a load, and to the resistor. The support plate is secured and the resistor thereon is electrically contacted by means of a resilient clip at one end, in the vicinity of a fixed end of the bimetal strip. An opposite end of the support is connected to a power source via a movable contact spring. An opposite free end of the bimetal strip acts directly on the switch contacts to disconnect power upon bending of the bimetal strip with heat. The bimetal strip and a control operator for biasing the bimetal strip are shaped like an L, with two legs pivotable around a pin adjacent the base of the bimetal strip.
Patent AU-643435-B2 (AU)
Title: Dry powder inhalation device
Inventor: WASS ANTHONY CHARLES LAMMOND
IPC: A61M15/00
Filed: 1990-04-30
Granted: 1993-11-18
Abstract: An inhalation device for dry powder comprising a housing defining a chamber (11) for receiving a dose of powdered medicament in communication with a patient port (23) in the form of a mouthpiece or nasal adapter, the inhalation device additionally comprising: deagglomeration/aerosolisation means to deagglomerate and/or assist aerosolisation of said dose of powdered medicament, which means is operable by a patient-independent energy output source (13), detection means (31) to detect patient inspiration through the patient port (23), and, control means (19) to actuate said deagglomeration/aerosolisation means in response to detection of patient inspiration by said detection means.
Patent AU-781802-B2 (AU)
Title: Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
Inventor: ZOGHBI HUDA Y
IPC: C12N5/08
Filed: 2000-06-01
Granted: 2005-06-16
Abstract: Compositions and methods are disclosed for the therapeutic use of an  atonal- associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an  atonal -associated gene inactivation is also disclosed having at least one  atonal -associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an  atonal -associated promoter sequence, wherein the inactivation of the  atonal -associated nucleic acid sequence prevents expression of the atonal-associated nucleic acid.
Patent AU-705737-B2 (AU)
Title: Prolonged nerve blockage by the combination of local anesthetics and glucocorticoids
Inventor: BERDE CHARLES B
IPC: A61K45/00
Filed: 1996-05-01
Granted: 1999-06-03
Abstract: Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a biodegradable polymer degrading significantly within a month, with at least 50% of the polymer degrading into non-toxic residues which are removed by the body within a two week period. Useful polymers include polyanhydrides, polylactic acid-glycolic acid copolymers and polyorthoesters containing a catalyst; polylactic acid-glycolic acid copolymers are preferred. Local anesthetics are incorporated into the polymer using a method that yields a uniform dispersion, preferably solvent casting. Prolonged release is obtained by incorporation of a glucocorticoid into the polymeric matrix or by co-administration of the glucocorticoid with the microspheres. The type of anesthetic and the quantity are selected based on the known pharmaceutical properties of these compounds.
Patent AU-588326-B2 (AU)
Title: Formation of partially demetallized laminates
Inventor: BECKETT DONALD EDWARD
IPC: B32B33/00
Filed: 1986-06-05
Granted: 1989-09-14
Abstract: A unique laminate suitable for formation into packages for the microwave heating of foodstuffs is provided. Metallized polymeric film is selectively demetallized to provide discrete metallized regions, the patterned film is laminated with outer stabilizing layers, for example, paper, and the laminate formed into a package. When used for heating a foodstuff, the discrete metallized region is located adjacent the foodstuff and on the opposite side of the foodstuff from the source of microwave energy. The metallized region results in conduction heat being applied to the foodstuff as well as microwave heating.
Patent AU-671715-B2 (AU)
Title: Device and process for bonding wearing parts at the ends of tools and receptacles used on civil engineering plant
Inventor: PASQUALINI CHARLES
IPC: E21C37/00
Filed: 1994-03-29
Granted: 1996-09-05
Abstract: The device is noteworthy in that the tooth (D) and the adaptor (A) relating thereto are arranged with respect to each other with complementary shapes to allow, after fitting, the formation and definition of one or more volumes (V) of variable shape, according to the need, the adaptor and the tooth being arranged with one or more openings allowing the insertion and fitting of a specific substance (M) in the abovementioned volume or volumes, said specific substance fulfilling the functions of immobilising the tooth with respect to the adaptor through absolute contact between the tooth and the adaptor by forming a contact cushion providing a distribution of the stresses and strains over all of the areas to be filled by the substance. <IMAGE>