baber/WOPTO huggingface dataset:
Patent DE-69738911-D1 (DE)
Inventor: PIZI ANTHONY C
IPC: G06F3/048
Filed: 1997-05-05
Granted: 2008-09-25
Abstract: A novel computer workstation interface program provides for subordination of select operating system and application commands. The system permits a seamless integration of distinct applications with a common context controller that permits inter-application communication regarding the operating environment. System resources are managed to insure critical operations retain priority, while permitting access to resources as they are freed by the system. The workstation enhances user productivity by creating a work environment orchestrated around task and function rather than specific application and file paradigms.
Patent DE-69801403-D1 (DE)
Inventor: SPITZ ROGER
IPC: C08F4/6592
Filed: 1998-06-08
Granted: 2001-09-27
Abstract: A method for the preparation of solid catalytic composition used for (co)polymerisation of olefins, comprises: (a) formation of solid (S1) by reacting a support in particle form and a halogen derivative represented by formula: R<1>M<1>X<1>3; (in which R<1> = hydrocarbon radical; M<1> = silicon, germanium or tin; and X<1> = halogen;) (b) reaction between (S1) and compound (C), which can graft at least one group with a cyclo-alkadienyl skeleton (L) to M<1>, at least one C atom from cyclo-alkadienyl radical being bonded to at least one H atom; the reaction giving a solid (S2); (c) reaction between (S2) and deprotonating compound (D) with formula: R<2>M<2>X<2>n; (in which R<2> = H or hydrocarbon radical; M<2> = sodium, potassium, lithium or magnesium; X<2> = halogen; and n = 0 if M<2> = lithium, sodium or potassium or n=1 if M<2> = magnesium;) the reaction giving solid (S3); and (d) reaction between (S3) and transition metal derivative with formula: R<3)<y-z)M<3>Xz; (in which R<3> = hydrocarbon; M<3> = transition metal; X = halogen; y = 3 or 4; and z = 1 - y). Also claimed are: (i) catalytic solids obtained by above method; and (ii) method for polymerisation of at least one olefin in gaseous phase.
Patent DE-69801977-D1 (DE)
Inventor: BLAZEK DALIBOR
IPC: A45D29/04
Filed: 1998-07-09
Granted: 2001-11-15
Abstract: A file (1), particularly a nail file is formed of a body of glass (3) having a roughened abrading surface (2). The roughness may have an average depth, peak to valley in the range of 10 to 100 micrometers. The file may be made of flat, pressed or hardened glass. The file can have a variety of geometrical shapes and cross sections. The roughening can be achieved by etching with a HF solution.
Patent DE-69807222-D1 (DE)
Inventor: END WILLIAM
IPC: A61P43/00
Filed: 1998-05-25
Granted: 2002-09-19
Abstract: This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R<SUP>1 </SUP>is hydrogen, C<SUB>1-12</SUB>alkyl, Ar<SUP>1</SUP>, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyl, quinolinylC<SUB>1-6</SUB>alkyl, pyridylC<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, aminoC<SUB>1-6</SUB>alkyl, or a radical of formula -Alk<SUP>1</SUP>-C(-O)-R<SUP>9</SUP>, -Alk<SUP>1</SUP>-S(O)-R<SUP>9 </SUP>or -Alk<SUP>1</SUP>-S(O)<SUB>2</SUB>-R<SUP>9</SUP>; R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>16 </SUP>each independently are hydrogen, hydroxy, halo, cyano, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy, hydroxyC<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyloxy, aminoC<SUB>1-6</SUB>alkyloxy, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyloxy, Ar<SUP>1</SUP>, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyl, Ar<SUP>2</SUP>oxy, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyloxy, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C<SUB>2-6</SUB>alkenyl; R<SUP>4 </SUP>and R<SUP>5 </SUP>each independently are hydrogen, halo, Ar<SUB>1</SUB>, C<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkylthio, amino, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, C<SUB>1-6</SUB>alkylS(O)C<SUB>1-6</SUB>alkyl or C<SUB>1-6</SUB>alkylS(O)<SUB>2</SUB>C<SUB>1-6</SUB>alkyl; R<SUP>6 </SUP>and R<SUP>7 </SUP>each independently are hydrogen, halo, cyano, C<SUB>1-6</SUB>alkyl, 4,4-dimethyl-oxazolyl, C<SUB>1-6</SUB>alkyloxy or Ar<SUP>2</SUP>oxy; R<SUP>8 </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl, cyano, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, C<SUB>1-6</SUB>alkylcarbonylC<SUB>1-6</SUB>alkyl, cyanoC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxycarbonylC<SUB>1-6</SUB>alkyl, carboxyC<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, aminoC<SUB>1-6</SUB>alkyl, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, imidazolyl, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, aminocarbonylC<SUB>1-6</SUB>alkyl, or a radical of formula -O-R<SUP>10</SUP>, -S-R<SUP>10</SUP>, -N-R<SUP>11</SUP>R<SUP>12</SUP>; R<SUP>17 </SUP>is hydrogen, halo, cyano, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxycarbonyl, Ar<SUB>1</SUB>; R<SUP>18 </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy or halo; R<SUP>19 </SUP>is hydrogen or C<SUB>1-6</SUB>alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.
Patent DE-69807308-D1 (DE)
Inventor: BULLE CLAUDE
IPC: B42D15/00
Filed: 1998-12-18
Granted: 2002-09-26
Abstract: The secure document manufacture has a printer (IMP) recording personal information on labels (V1-V3), glued to support strips (FS), which is then cut to separate the labels. A gluing press (PR) attaches the labels to the secure document. The label and document transporting and processing mechanisms are controlled by a central controller (CC).
Patent DE-69810986-D1 (DE)
Inventor: DING NI
IPC: A61F2/82
Filed: 1998-04-21
Granted: 2003-03-06
Abstract: The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.
Patent DE-69819930-D1 (DE)
Inventor: CAVENY JOHN D
IPC: A01K29/00
Filed: 1998-07-02
Granted: 2003-12-24
Abstract: Carbon sequestration of greenhouse gases (CO2 and CH4) is effected through enhancement of plant growth using defoliation techniques with and without grazing animals. Processes and devices for measurement of the verifiable quantity of carbon sequestered are disclosed.
Patent DE-69825204-D1 (DE)
Inventor: SCHACHNER JOSEPH M
IPC: G01R35/00
Filed: 1998-04-30
Granted: 2004-09-02
Abstract: Self-calibration of a digitizer (104,106) is carried out by using a square-wave test signal which is digitized by the digitizer (104,106), and temporal positions of the digitized values output by the digitizer (104,106) are compared to respective reference periods of the test signal. The results of the comparison operations are then used by a microprocessor (110) to calculate a time delay for adjusting a clock signal supplied to the digitizer (104,106). <IMAGE>
Patent DE-69828033-D1 (DE)
Inventor: ISAZA J
IPC: A61M39/10
Filed: 1998-02-24
Granted: 2005-01-13
Abstract: The system and method for detecting disconnection <?delete-start id="DEL-S-00001" date="20060808" ?>and occlusion<?delete-end id="DEL-S-00001" ?> of a tubing system of a patient ventilator detects disconnection of the tubing system, opens the exhalation valve, delivers an idle flow of breathing gas to the tubing system, disables breath triggering, and generates an alarm. A reconnection of the tubing system can also be detected, to initiate resumption of pressure supported inspiration. <?delete-start id="DEL-S-00002" date="20060808" ?>For occlusion detection, the pressure drop in the tubing system is determined by pressure sensors in the inspiratory and expiratory airways of the tubing system. The two pressure drop values are compared, and once occlusion is detected, an alarm is generated, and the ventilator responds to protect the patient from over distension. Abatement of the occlusion can also be monitored in a pressure based occlusion status cycling mode, and the ventilator can revert back to normal ventilation when the circuit occlusion or exhaust port occlusion are not detected.<?delete-end id="DEL-S-00002" ?>
Patent DE-69833581-D1 (DE)
Inventor: GOODWIN DAVID A
IPC: B29C65/04
Filed: 1998-12-30
Granted: 2006-04-27
Abstract: The present invention includes a method for forming a resilient bladder structure for use in the sole of footwear. The method comprises the steps of forming a shell from a flexible material (28) to have a floor and a perimeter sidewall extending from the floor; placing a core (24), having spaced apart outer surfaces connected together by a plurality of connecting members, into the shell within the area bounded by the sidewalls; enclosing the shell and core with a covering sheet (26); bonding the floor of the shell to one outer surface of the core and the covering sheet to the other outer surface of the core by applying pressure and heat to the shell-core-covering sheet assembly to compress the core during the bonding step; preventing bonding of the sidewall to the covering sheet during the compression of the core; and bonding the covering sheet to an outer edge of the perimeter sidewall of the shell to form a sealed bladder structure; and placing fluid into the interior of the bladder so that the plurality of connecting members are placed under tension. The present invention is also directed to a bladder for use as a cushioning element and footwear incorporating the bladder. The enclosed core is formed of spaced apart first and second fabric layers (34, 36) connected together by a plurality of connecting yarns (38). The shell is formed of see-through plastic material whereby the connecting yarns are visible through the sidewall (32). The plurality of connecting yams preferably are arranged in bands (44) with gaps (46) devoid of connecting yarns between adjacent bands, and the ends of the bands and the gaps are visible through the sidewall. <IMAGE>
Patent DE-69833779-D1 (DE)
Inventor: GORCZYNSKI M
IPC: C12N15/12
Filed: 1998-11-06
Granted: 2006-05-04
Abstract: Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.
Patent DE-69835590-D1 (DE)
Inventor: BARKER NICK
IPC: A61K48/00
Filed: 1998-03-20
Granted: 2006-09-28
Abstract: The APC tumor suppressor protein binds to  beta -catenin, a protein recently shown to interact with Tcf/Lef transcription factors. Here, the gene encoding a Tcf family member that is expressed in colonic epithelium (hTcf-4) a was cloned and characterized. hTcf-4 transactivates transcription only when associated with  beta -catenin. Nuclei of APC-/- colon carcinoma cells were found to contain a stable  beta -catenin-hTCF-4 complex that was constitutively active, as measured by transcription of a Tcf reporter gene. Reintroduction of APC removed  beta -catenin from hTcf4 and abrogated the transcriptional transactivation. Constitutive transcription of TCF target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium. It is also shown here that the products of mutant APC genes found in colorectal tumors are defective in regulating  beta -catenin/Tcf-4 transcrpitional activation. Furthermore, colorectal tumors with intact APC genes were shown to contain subtle activating mutations of  beta -catenin that altered functionally significant phosphorylation sites. These results indicate that regulation of  beta -catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or  beta -catenin.
Patent DE-69841142-D1 (DE)
Inventor: GABIZON ALBERTO A
IPC: A61K47/10
Filed: 1998-12-01
Granted: 2009-10-22
Abstract: A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.
Patent DE-69906228-D1 (DE)
Inventor: VAN DEN BERG KAREL
IPC: A01J7/04
Filed: 1999-07-01
Granted: 2003-04-30
Abstract: The invention relates to an implement for milking and/or cleaning the udder and/or the teats of animals, comprising a milking machine and/or a cleaning device for cleaning the udder and/or the teats of an animal, being provided with at least one teat cup (4) and at least one disinfecting device (1) provided with at least one light source (3) transmitting ultraviolet rays, said light source (3) being disposed in the teat cup (4). <IMAGE>
Patent DE-69910787-D1 (DE)
Inventor: KARABELAS KOSTAS
IPC: A61P25/00
Filed: 1999-06-23
Granted: 2003-10-02
Abstract: The present invention relates to compounds of formula (I) wherein: Ar1 or Ar2 is an optionally substituted indole, and the other group is an optionally substituted aromatic or heteroaromatic group, preferably an optionally substituted indole, X is O or S, and R2 is H, hydroxy, amino, C1-6alkyl, hydroxyC1-6alkyl or aminoC1-6alkyl, and salts and solvates thereof and solvates of such salts, and the use of such compounds in medical therapies.
Patent DE-69911962-D1 (DE)
Inventor: VAN DEN BERG WILLEM
IPC: B01J3/00
Filed: 1999-05-27
Granted: 2003-11-13
Abstract: The invention relates to a high-pressure device (1) having a cylindrical high-pressure vessel (3) and prestressing means in order to exert an axial pressure on the vessel. The vessel (3) can have been formed from a number of layers of composite material, such as glass, carbon or aramide fibers which are oriented in the peripheral direction and are embedded in a matrix of epoxy resin or polyurethane. By applying the axial prestress to the pressure vessel (3), the tangential stress is distributed more uniformly over the wall thickness of the high-pressure vessel (3), the stress decreasing at the inside of the wall and increasing at the outside thereof. As a result, the innermost fibers of a high-pressure vessel (3) made of composite material are subjected to appreciably less stress, which has a beneficial effect on the life of the high-pressure vessel (3), and all fibers of the wall are utilized effectively. Preferably, the prestressing means comprise a pressure ring (14) which can be brought into engagement around the pressure-generating piston (9) with one end face of the high-pressure vessel (3).
Patent DE-69918532-D1 (DE)
Inventor: LOOS BERND
IPC: B23Q3/12
Filed: 1999-12-06
Granted: 2004-08-12
Abstract: For coupling the spindle and the tool holder there are provided radially displaceable locking members (20), which, in the coupled state, are supported against radially outward displacement by a positioning sleeve (21) arranged on the receiving body and located in its locking position, and when the positioning sleeve is displaced axially forwards against spring pressure into a release position, the locking members are displaceable radially outwards, so that the tool holder (10) can be removed from the spindle. Between the receiving body and the positioning sleeve there is arranged a damping spring (25) supporting the positioning sleeve in its locking position.
Patent DE-69924712-D1 (DE)
Inventor: WALZER F
IPC: C08F210/18
Filed: 1999-03-03
Granted: 2005-05-19
Abstract: The invention is directed to olefin polymerization processes using bridged hafnocene catalyst complexes comprising highly substituted noncoordinating anions that are surprisingly stable under high temperature olefin polymerization processes such that olefin copolymers having significant amount of incorporated comonomer can be prepared with high molecular weights. More specifically, the invention is a polymerization process for ethylene copolymers having a melt index of about 0.87 to about 0.930 comprising contacting, under homogeneous polymerization conditions at a reaction temperature at or above 140° C. to 225° C., ethylene and one or more comonomers capable of insertion polymerization with a bridged hafnocene catalyst complex derived from A) a biscyclopentadienyl hafnium organometallic compound having i) at least one unsubstituted cyclopentadienyl ligand or aromatic fused-ring substituted cyclopentadienyl ligand, ii) one aromatic fused-ring substituted cyclopentadienyl ligand, iii) and a covalent bridge connecting the two cyclopentadienyl ligands, said bridge comprising a single carbon or silicon atom; and B) an activating cocatalyst, precursor ionic compound comprising a halogenated tetraaryl-substituted Group 13 anion wherein each aryl substituent contains at least two cyclic aromatic rings.
Patent DE-69928521-D1 (DE)
Inventor: GOMEZ-MANCILLA BALTAZAR
IPC: A61K31/425
Filed: 1999-05-07
Granted: 2005-12-29
Abstract: This invention discloses new uses and treatments involving cabergoline, pramipexole and new combinations of cabergoline plus pramipexole used to treat patients. Here we disclose the use of cabergoline or pramipexole to treat PSP and MSA. Also disclosed is a combination treatment of cabergoline and pramipexole provided concurrently to a patient in need thereof for the treatment of various central nervous system diseases and in particular for the treatment of Parkinson's Disease (PD), but also for PSP and MSA.
Patent DE-69929232-D1 (DE)
Inventor: SCHILLER T
IPC: C07K19/00
Filed: 1999-10-20
Granted: 2006-02-02
Abstract: The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles, and methods of use of the foregoing are provided for the study of B cell tolerance and the treatment or prevention of human diseases, which involve the onset of B cell tolerance, such as chronic viral infection, chronic inflammatory disease, and neoplasia.
Patent DE-69937564-D1 (DE)
Inventor: WHEELER RONALD E
IPC: A61K36/736
Filed: 1999-08-03
Granted: 2007-12-27
Abstract: A composition providing an all-natural, non-surgical preventative of or improvement to disorders of the prostate gland is described. The invention relates to a composition for the prevention of or improvement of prostatitis, and for relieving symptoms and improving objective signs of prostatitis. The formula of the composition preferably includes the following ingredients each in a therapeutically effective amount: Vitamin C, Vitamin B6, Vitamin E, zinc, glycine, L-alanine, Glutamic acid, Saw palmetto, Pygeum extract, Pumpkin seed, Stinging nettle, Echinacea, garlic, Ginkgo leaves, and selenium.
Patent DE-69939649-D1 (DE)
Inventor: HURTTA ARI
IPC: H04Q1/24
Filed: 1999-03-05
Granted: 2008-11-13
Abstract: The invention relates to a redundant switching arrangement using a first and second switching network (SWF_A, SWF_B) or other switching element. The switching elements are used to carry out switching operations in the same way, so that one of the switching elements serves as an active switching element whose switching operations are utilised, while the other switching element serves as a passive switching element backing up the active switching element. To ensure that any faults occurring in the switching elements in such a redundant switching arrangement are detected as quickly as possible, their operation is monitored by comparing the data of the corresponding output channels of the first and second switching elements, and if such a comparison shows that the data contained in any of the corresponding output channels are not identical, an internal test is carried out for at least one of the switching elements to verify the data of the output channel involved. The internal compare test(s) is/are used as a basis for selecting the switching element to continue to serve as the active switching element.
Patent DE-69939721-D1 (DE)
Inventor: DEKKER JOHANNES
IPC: A61P17/00
Filed: 1999-10-08
Granted: 2008-11-20
Abstract: A pharmaceutical composition comprising fulvic acid, salt, ester or derivative thereof as active agent is disclosed. The composition is preferably administered orally or topically for treating a condition in a human or animal. The condition may, for example, be inflammation, acne, eczema or bacterial or fungal or viral infections.
Patent DE-69939820-D1 (DE)
Inventor: MARKS JAMES D
IPC: A61K45/00
Filed: 1999-04-23
Granted: 2008-12-11
Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalizing into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.
Patent DE-69939829-D1 (DE)
Inventor: BISGARD-FRANTZEN HENRIK
IPC: C12N15/09
Filed: 1999-07-02
Granted: 2008-12-11
Abstract: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant.