Patent SG-11201808799S-A (SG)
Title: Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors
Inventor: CAMPBELL JOHN EMMERSON
IPC: C07D401/12
Filed: 2017-04-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property —, Organization 11M1111101110101011111 HO 11111 01113111113010111011111111101111011# International Bureau ... ..... ..Yi j (10) International Publication Number ..... .„,,,, (43) International Publication Date WO 2017/181177 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: OUYANG, Lian et al.; Cooley LLP, 1299 CO7D 231/38 (2006.01) A61K 31/506 (2006.01) Pennsylvania Avenue, NW, Suite 700, Washington, Dis- CO7D 401/12 (2006.01) A61K 31/44 (2006.01) trict of Columbia 20004 (US). C07D 239/48 (2006.01) A61P 7/06 (2006.01) A61K 31/505 (2006.01) A61P 35/02 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/US2017/027918 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 17 April 2017 (17.04.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 62/323,602 15 April 2016 (15.04.2016) US ZA, ZM, ZW. 62/348,837 10 June 2016 (10.06.2016) US (84) Designated States (unless otherwise indicated, for every 62/402,997 30 September 2016 (30.09.2016) US kind of regional protection available): ARIPO (BW, GH, (71) Applicant: EPIZYME, INC. [US/US]; 400 Technology GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Square, 4th Floor, Cambridge, Massachusetts 02139 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: CAMPBELL, John Emmerson; 581 Mt. Au- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, burn Street, Unit #1, Cambridge, Massachusetts 02138 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (US). DUNCAN, Kenneth William; 132 Roosevelt Aven- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ue, Norwood, Massachusetts 02062 (US). FOLEY, Megan GW, KM, ML, MR, NE, SN, TD, TG). — _ Alene; 34 Alpine Street, Somerville, Massachusetts 02144 (US). HARVEY, Darren Martin; 3 Barker Road, Acton, Published: Massachusetts 01720 (US). KUNTZ, Kevin Wayne; 8 — with international search report (Art. 21(3)) = New Village Road, Woburn, Massachusetts 01801 (US). before the expiration of the time limit for amending the MILLS, James Edward John; Holly End, The Street, claims and to be republished in the event of receipt of Worth, Deal Kent CT14 ODF (GB). MUNCHHOF, Mi- amendments (Rule 48.2(h)) chael John; 266 West Road, Salem, Connecticut 06420 = = (US). = = = = = = = Il IN IN 11 11 GC 11 (54) Title: AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS Il © (57) : The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates N to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibi- tion of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.