Patent SG-11201909602T-A (SG)
Title: Compositions and methods involving probiotic molecules
Inventor: CELLA MONICA ANGELA
IPC: C07K14/00
Filed: 2018-03-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT (51) International Patent Classification: CO7K 7/06 (2006.01) A61L 29/16 (2006.01) A23L 33/135 (2016.01) A61L 31/16 (2006.01) A23L 33/195 (2016.01) A61P 31/04 (2006.01) A61K 35/741 (2015.01) CO7K 14/00 (2006.01) A61K 38/08 (2006.01) CO7K 14/195 (2006.01) A61K 38/10 (2006.01) CO7K 14/315 (2006.01) A61K 38/16 (2006.01) CO7K 14/335 (2006.01) A61L 15/44 (2006.01) CO7K 7/08 (2006.01) A61L 27/54 (2006.01) C12N 1/20 (2006.01) (21) International Application Number: PCT/CA2018/050319 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/472,047 16 March 2017 (16.03.2017) US (71) Applicant: MICROSINTESIS INC. [CA/CA]; 329 Sum- mer Avenue, Oakville, Ontario L6J 1S7 (CA). (72) Inventors: CELLA, Monica Angela; 39 Ducks Landing, Apt. 302, Stratford, Prince Edward Island C1B 2X8 (CA). CURTIS, Sarah M.; 130 Balsam Road, P.O. Box 1065, Atikokan, Ontario POT 1C0 (CA). ROEPKE, Jonathon Patrick; 245 Queen Street, Apt. 3, Charlottetown, Prince Edward Island CIA 4B9 (CA). (74) Agent: LOWTHERS, Erica E. et al.; Aird & McBurney LP, Brookfield Place, 181 Bay Street, Suite 1800, Toronto, Ontario M5J 2T9 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMPOSITIONS AND METHODS INVOLVING PROBIOTIC MOLECULES Biological Rep 1 omit VIII °nolo om woo 1111 VIII oimIE (10) International Publication Number WO 2018/165764 Al LDH In hibit ion ( %) 100.00 90.00 80.00 70.00 60.00 50.00 40.00 30.00 20.00 10.00 0.00 .4.— Biological Rep 1 71' N 00 O N O 0 5 10 15 Concentration of Cell free supernatant (mg/mL) Figure 1 (57) : Provided are peptides that are derived from probiotic bacteria that may be useful for preventing and/or treating enteric infections or non-enteric infections in a subject. The peptides may also find use for reducing the virulence of enteric infections or non- enteric infections in a subject. Also provided are compositions of the peptides and compositions comprising culture fractions of the probiotic bacteria. [Continued on next page] WO 2018/165764 Al MIDEDIM01101 DIDEVE3011111111011111111111I11E11111111111 Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE