baber/WOPTO huggingface dataset:
Patent CA-3016755-A1 (CA)
Inventor: UCKERT WOLFGANG
IPC: C12N15/113
Filed: 2017-03-15
Abstract: The present invention relates to the field of genetic engineering, in particular, to a transposon-based transfection kit suitable for transfection of primary cells, such as T cells, comprising mRNA encoding a transposase, or reagents for generating mRNA encoding said transposase, as well as minicircle DNA comprising the transposon. The invention also relates to a nucleic acid, preferably, a DNA minicircle, comprising a transposon, wherein the transposon encodes a protein and at least one miRNA, wherein the sequences encoding the miRNA are located in an intron and expression of the protein and the miRNA is regulated by the same promoter. The invention also provides a population of cells obtainable with the method of the invention. Methods of transfection are also provided, as well as medical use, e.g. in immunotherapy, in particular, in adoptive T cell therapy or T cell receptor (TCR) or chimeric antigen receptor (CAR) gene therapy.
Patent CA-3017214-A1 (CA)
Inventor: LOW PHILIP S
IPC: A61K31/18
Filed: 2017-03-16
Abstract: The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in SPECT imaging methods.
Patent CA-3017618-A1 (CA)
Title: System for producing flatbread and method for the provision of same
Inventor: MULLER JONAS
IPC: A21C5/00
Filed: 2017-02-22
Abstract: The invention relates to a system for producing flatbread, comprising a closed portion capsule (1) that has a pre-shaped dough body (7) arranged therein, preferably an individual portion dough body, consisting of a, preferably, yeast-free dough material on the basis of flour and water and preferably on the basis of wheat flour and water, in order to produce flatbread in a domestic flatbread baking device, with the dough body (7) being shaped. According to the invention, the dough body (7) comprises a dough crust all the way around made of the dough material and enclosing a core that consists of a mass of raw dough.
Patent CA-3020902-A1 (CA)
Inventor: PULLEN ADRIAN
IPC: H01M10/052
Filed: 2017-04-27
Abstract: Provided are electrochemically active secondary particles that provide excellent capacity and improved cycle life. The particles are characterized by a plurality of nanocrystals with small average crystallite size. The reduced crystallite size reduces impedance generation during cycling thereby improving capacity and cycle life. Also provided are methods of forming electrochemically active materials, as well as electrodes and electrochemical cells employing the secondary particles.
Patent CA-3021271-A1 (CA)
Inventor: HINKEN AARON CURTIS
IPC: A61P21/00
Filed: 2017-04-24
Abstract: Methods of treating muscle wasting and other disorders with NOPE extracellular domain (ECD) polypeptides and NOPE ECD fusion molecules are provided.
Patent CA-3023228-A1 (CA)
Title: 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers
Inventor: GRECO MICHAEL NICHOLAS
IPC: C07D403/04
Filed: 2017-05-11
Abstract: Methods of using substituted 2-anilinopyrimidine derivatives, and pharmaceutically acceptable salts, solvates, or compositions, for the treatment of brain cancers, in particular EGFR-mediated metastatic brain cancer, are disclosed.
Patent CA-3025124-A1 (CA)
Title: Virus de l'herpes a glycoproteine h modifiee pour la propagation dans une cellule
Inventor: NICOSIA ALFREDO
IPC: C12N15/62
Filed: 2017-06-08
Abstract: La présente invention concerne un virus recombinant de l'herpès qui comprend le facteur de transcription GCN4 de la levure ou une partie correspondante, fusionné à ou introduit dans la glycoprotéine H et qui est capable de se lier à une molécule cible présente sur une cellule pour la propagation et la production du virus de l'herpès. Le virus de l'herpès peut comprendre une modification supplémentaire dans la glycoprotéine D et/ou dans la glycoprotéine B pour le reciblage du virus de l'herpès sur une cellule malade. La présente invention concerne en outre un acide nucléique et un vecteur codant pour la gH, un polypeptide comprenant la gH et une cellule comprenant le virus de l'herpès, l'acide nucléique, le vecteur ou le polypeptide. De plus, la présente invention concerne une cellule présentant, de manière accessible sur la surface, une molécule cible pour le facteur de transcription GCN4 de la levure ou une partie correspondante ainsi qu'un procédé pour produire le virus de l'herpès dans ladite cellule.
Patent CA-3025604-A1 (CA)
Inventor: RAIZADA MANISH N
IPC: A01N63/27
Filed: 2018-11-28
Abstract: Described are isolated strains of bacterial endophytes isolated from maize useful for the treatment of plants and associated methods and formulations. The bacterial endophyte may be applied to plants to promote growth. In one embodiment, the bacterial endophyte is an Enterobacter sp. known as 3D9 and deposited as IDAC strain 190917-01.
Patent CA-3025698-A1 (CA)
Title: Polytherapie comprenant une cetone polyinsaturee et un inhibiteur de la calcineurine
Inventor: JOHANSEN BERIT
IPC: A61K38/13
Filed: 2017-06-05
Abstract: L'invention concerne une composition pharmaceutique synergique pour une utilisation simultanée, parallèle, séquentielle ou séparée comprenant une cétone polyinsaturée et un inhibiteur de la calcineurine. La composition est utile dans le traitement et la prévention de troubles cutanés.
Patent CA-3026086-A1 (CA)
Inventor: BEUTERBAUGH AARON M
IPC: E21B43/267
Filed: 2016-07-27
Abstract: Provided are methods for propping a fracture. An example method comprises providing a treatment fluid comprising a polyester, a water-miscible solvent, and a proppant and then pumping the treatment fluid through an aqueous fluid within a wellbore to form an amorphous polymeric web. The method further comprises pumping the amorphous polymeric web into a fracture within a subterranean formation and then allowing the amorphous polymeric web to dissolve.
Patent CA-3027954-A1 (CA)
Title: Methods for detection and typing of nucleic acids
Inventor: MOSER MICHAEL JAMES
IPC: C12Q1/6876
Filed: 2006-06-06
Abstract: Disclosed are methods and kits for identifying and characterizing polynucleotide sequences in a sample which may include a heterogeneous sample. Some of the methods and kits are directed to the identification and characterization of a virus in a sample, which may include HIV capable of cause AIDS or AIDS-like symptoms. The virus may be HIV-1, and may also include drug resistant mutations. The methods may include reacting a mixture that includes, in addition to nucleic acid isolated from the sample, at least one oligonucleotide capable of specifically hybridizing to HIV nucleic acid where the oligonucleotide includes at least one non-natural base. In addition, the methods may include detection of one or more mutations in HIV nucleic acid that are associated with drug resistance.
Patent CA-3029978-A1 (CA)
Title: Systeme pour mousse de polyurethane a stabilite dimensionnelle et exempte d'isocyanate
Inventor: THOMAS MEGAN
IPC: C08G12/20
Filed: 2017-06-19
Abstract: L'invention concerne un système de mousse polymère comprenant un polyaldéhyde, une poudre inorganique, un polycarbamate, un agent d'expansion et un catalyseur acide, le polyaldéhyde se trouvant dans un côté A du système de mousse polymère et le polycarbamate se trouvant dans un côté B du système de mousse polymère, la poudre inorganique étant choisie dans un groupe constitué par les oxydes et les hydroxydes du groupe II, le polyaldéhyde présentant une fonctionnalité moyenne de plus de un et de trois ou moins, le polycarbamate présentant une fonctionnalité moyenne de 3,4 ou plus et de 4,2 ou moins, le polycarbamate présentant un poids équivalent moyen de 200 grammes par équivalent ou plus et de 325 grammes par équivalent ou moins et la grosseur moyenne de particule de la poudre inorganique, en micromètres, divisée par le rapport des concentrations, en millimoles, en poudre organique et en catalyseur acide étant de 2,5 ou plus et de 9,3 ou moins.
Patent CA-3030599-A1 (CA)
Title: Synthesis method and intermediate for prothioconazole and enantiomer thereof
Inventor: SHENG QIUJU
IPC: C07D249/12
Filed: 2017-06-26
Abstract: A synthesis method and intermediate for prothioconazole and enantiomer thereof. The method comprises: reacting a hydrazine with a glyoxylic acid to obtain a hydrazono-acetic acid intermediate, and reacting the intermediate with a thiocyanate to obtain a prothioconazole target product. The method is highly selective of reaction areas, generates little by-products, and has a high yield. The method does not have a high equipment requirement and does not need water-free or oxygen-free techniques. The method has simple techniques, generates little gas, liquid, or solid wastes, and is applicable for industrial production.
Patent CA-3032256-A1 (CA)
Inventor: CERVELLO STEVEN
IPC: B61F19/02
Filed: 2017-08-02
Abstract: La présente invention concerne un élément de protection d'essieux de chemin de fer, l'élément de protection étant constitué d'un patin pourvu d'une pluralité de rainures transversales sans laquelle le patin ne pourrait pas être enroulé sur l'axe à température ambiante. Le patin est constitué d'un matériau présentant une épaisseur élevée ou une résistance élevée, qui est respectivement comprise entre 5 mm et 10 mm et entre 50 kJ/m2 et 80 kJ/m2. Grâce à la combinaison des valeurs d'épaisseur et de résilience, en plus des rainures, le patin peut être enroulé manuellement sur l'axe, sans l'aide de presses et sans chauffage préalable. Ainsi, la solution selon la présente invention combine les avantages de facilité d'installation, telle que la possibilité d'enrouler manuellement l'élément de protection sur l'axe, avec l'efficacité de la protection assurée par des éléments de protection rigides.
Patent CA-3033001-A1 (CA)
Inventor: HARLING JOHN DAVID
IPC: A61P35/00
Filed: 2017-08-16
Abstract: A method of treating disorders associated with aberrant kinase activity, wherein the kinase is. Adaptor-associated protein kinase 1 (AAK1), Aurora Kinase A (AURKA), Aurora Kinase B (AURKB), Bruton's Tyrosine Kinase (BTK), Interleukin-1 receptor-associated kinase 3 (IRAK3), Protein tyrosine kinase 2 beta (PTK2B), Tyrosine-protein kinase Tec (TEC), Serine/threonine- protein kinase Wee1 (WEE1), Cyclin G-associated kinase (GAK), Large Tumour suppressor Kinase (LATS1),Focal Adhesion Kinase (PTK2), Ribosomal protein S6 kinase alpha-1 (RPS6KA1) said method comprising degrading said kinase.
Patent CA-3034562-A1 (CA)
Inventor: HENDERSON RICHARD S
IPC: F27D27/00
Filed: 2017-08-29
Abstract: A molten metal scrap submergence system comprising a furnace and a vortexing scrap submergence well. The vortexing scrap submergence well includes a diverter suspended above the well and oriented for immersion in a bath of molten metal circulating within the well. The system, or an alternative scrap submergence system, can include a hood element disposed in an overlapping position with regard to a top opening of the scrap submergence well. The hood at least substantially seals the top opening. The hood element includes a scrap piece feed chute and a burner allowing carbon containing vapor evaporated from the surface of the molten scrap pieces to combust and form predominantly water. The system, or an alternative scrap submergence system can include internal side walls of the well with a first diameter portion adjacent and above said ramp and a second, larger diameter portion above said first portion.
Patent CA-3036042-A1 (CA)
Title: Package
Inventor: FRENCH JORDAN ROBERT
IPC: B65D43/16
Filed: 2019-03-07
Abstract: A package having a container and a selectively openable lid to selectively allow access to the container is disclosed.
Patent CA-3037542-A1 (CA)
Title: Procede de determination de risques associes a des maladies cardiovasculaires
Inventor: PUSSINEN PIRKKO
IPC: G01N33/573
Filed: 2017-09-27
Abstract: La présente invention concerne un nouveau procédé de détermination du risque de maladies cardiovasculaires, comprenant la détection de MMP-8 et de CRP dans un échantillon et la comparaison des quantités détectées avec des valeurs prédéterminées respectives de MMP-8 et de CRP, la détection de niveaux élevés de MMP-8 et de CRP indiquant la présence ou le risque d'un événement ou d'une maladie cardiovasculaire. La présente invention concerne également l'utilisation d'une détection de MMP-8 et de CRP en vue de prédire un risque d'apparition d'un événement cardiovasculaire, en vue de surveiller l'effet d'une thérapie sur un événement cardiovasculaire ou sur une maladie cardiovasculaire ou en vue de détecter la présence d'une maladie cardiovasculaire subclinique. L'invention concerne également un procédé de construction d'un modèle de prédiction de risque d'une présence d'une maladie cardiovasculaire (CVD) ou d'un risque d'événements CVD.
Patent CA-3038052-A1 (CA)
Inventor: CAMPBELL RICHARD V
IPC: F16G11/04
Filed: 2017-09-21
Abstract: A method for attaching an anchor to an end of a tensile member by inverting the assembly of anchor and tensile member arid injecting pressurised potting compound. A length of filaments of the tensile member are placed within a cavity through the anchor. The anchor and filaments are placed in an inverted position, with the distal end of the anchor facing downward and the cable extending upward out of the anchor. If the anchor has an open distal end this is sealed. Liquid potting compound is injected into the anchor cavity and allowed to solidify. During the solidification process, a controlled translation (pulling) of the cable is preferably introduced.
Patent CA-3038349-A1 (CA)
Inventor: LAI NAM HAI
IPC: A61K47/24
Filed: 2019-03-29
Abstract: The present invention relates to a process of producing a nano-CBD liposome system comprises: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 by a stirrer at a speed of 300 to 500 rpm and simultaneously heating to a temperature ranging from 40 to 60°C within 4 to 8 hours; (ii) preparing a liposome carrier consisting of lecithin, olive oil in a ratio by mass of 1:3 mixed in a themostatic bath at a temperature from 40 to 60°C to ensure that lecithin completely dissolves in oil, stirring homogeneously; (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature ranging from 40 to 60°C, stirring at a speed of 800 to 1000 rpm for 1 to 2 hours; (iv) cooling the resulting mixture to 25°C and injecting one volumn of distilled water between 1 and 1.5 L by using hight- frequency nozzles at a frequency of 60 Hz, drop sizes ranging from 10 to 20 pm, injecting capacity of 10 ml/ min, with the temperature of distilled water of 25°C, giving a liposome suspension - water solution; (v) homogenizing the mixture of liposome suspension - water solution by injecting through 30 Mpa high pressure homogenizers to obtain a nano-CBD liposome system which is a homogeneous, stable mixture ensured with the particle sizes <200 nm.
Patent CA-3038949-A1 (CA)
Title: Systems and methods for automatically identifying a checkout webpage and injecting a virtual token
Inventor: BENKREIRA ABDELKADER M'HAMED
IPC: G06Q20/00
Filed: 2019-04-03
Abstract: A system includes a processing system and a memory system. The processing system includes one or more processors. The memory system includes one or more computer-readable media that contain instructions that, when executed by the processing system, cause the processing system to perform operations. The operations include detecting a loading of a webpage including a document object model (DOM). The operations also include analyzing the DOM to identify a first element in the DOM. The operations also include determining, based on the first element, that the webpage is configured to accept payments. The operations also include receiving, from a provider server, a virtual token which corresponds to a user account. The operations also include injecting information from the virtual token into one or more account number fields on the webpage.
Patent CA-3039098-A1 (CA)
Inventor: SIGEL GARY A
IPC: C09D5/00
Filed: 2017-10-04
Abstract: Abrasion resistant water/solvent based coatings, which may be applied in the field. Flooring products including such abrasion resistant water/solvent based coatings and methods of applying such abrasion resistant water/solvent based coatings to flooring products.
Patent CA-3040919-A1 (CA)
Inventor: GOTCHEV DIMITAR B
IPC: C07D498/04
Filed: 2017-11-03
Abstract: The present invention relates to the technical field of therapeutic compositions of matter. The present invention includes substituted pyridinone-containing tricyclic compounds, including compounds of Formula (III): wherein X1, X2, X3, X4, R1, R2, R3, R3, and R7 are defined elsewhere herein, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
Patent CA-3041304-A1 (CA)
Title: Vecteurs de recombinaison exprimant des antigenes de virus de la grippe aviaire et utilisations associees
Inventor: PRITCHARD JOYCE
IPC: A61K39/00
Filed: 2017-10-20
Abstract: La présente invention concerne des vecteurs viraux de recombinaison qui contiennent et expriment des antigènes d'agents pathogènes aviaires, des compositions comprenant lesdits vecteurs viraux de recombinaison, et des vaccins polyvalents comprenant lesdits vecteurs viraux de recombinaison. La présente invention concerne également des procédés de vaccination contre une variété de pathogènes aviaires et un procédé de production de vecteurs viraux de recombinaison.
Patent CA-3042081-A1 (CA)
Inventor: MIRACLE GREGORY SCOT
IPC: C11D3/42
Filed: 2019-05-02
Abstract: The present application relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two constituents: at least one chromophore constituent and at least one polymeric constituent. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to light, or they may absorb light to reflect these same shades. This disclosure also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.
Patent CA-3043369-A1 (CA)
Title: Volume booster with stabilized trim
Inventor: LOVELL MICHEL K
IPC: F16K27/02
Filed: 2011-09-13
Abstract: A fluid flow control device includes a body having an inlet connection, an outlet connection, and a discharge port. A supply path extends between the inlet connection and the outlet connection and a booster module is disposed within the body. The booster module includes a control element and an actuator element and defines an exhaust path extending between the outlet connection and the discharge port. A supply port is disposed within the booster module along the supply path between the inlet connection and the outlet connection and at least a first damping means operatively connected to the booster module.
Patent CA-3043719-A1 (CA)
Title: Cable ladder rack bonding
Inventor: MCADOO MICHAEL WRAY
IPC: H02G3/06
Filed: 2019-05-16
Abstract: The present disclosure describes improved splices for joining ladder rack sections that provide a conductive ground connection, without requiring removal of paint, drilling additional holes, or installation of ground straps between sections. The splices also provide a solid physical connection between ladder rack sections, ensuring safety and stability of the rack system.
Patent CA-3046430-A1 (CA)
Title: Process for preparing a lactose-free milk
Inventor: ZAMBRINI ANGELO VITTORIO
IPC: A23C9/142
Filed: 2017-12-21
Abstract: Process for preparing lactose-free skimmed, partially skimmed and whole milk, comprising the following steps: 1) pasteurization and skimming, 2) enzymatic hydrolysis of the skimmed milk by lactase enzyme, 3) microfiltration of the hydrolysed skimmed milk and obtainment of a microfiltration retentate (RMF) and of a microfiltration permeate (PMF), 4) PMF ultrafiltration and obtainment of an ultrafiltration retentate (RUF) and of an ultrafiltration permeate (PUF), 5) first PUF nanofiltration and obtainment of the first nanofiltration retentate (RNF l) and of a first nanofiltration permeate (PNF l), 6) second PNF l nanofiltration and obtainment of a second nanofiltration retentate (RNF2) and of a second nanofiltration permeate (PNF2), and 7) final step: obtainment of lactose-free milk by mixing one or more of the fractions deriving from one or more of the previous steps, which is characterized in that: (I) the first nanofiltration of step 5) is carried out with membranes having a molecular weight cut-off ranging from 400 to 600 Da and the second nanofiltration is carried out with membranes having a molecular weight cut-off ranging from 150 to 250 Da, and (II) the final step 7) is carried out by mixing a composition comprising at least RUF, RNFl and PNF2.
Patent CA-3047596-A1 (CA)
Title: Methods of preparing aluminum alloy products for bonding
Inventor: EPP JUNE M
IPC: C21D9/46
Filed: 2018-01-11
Abstract: Disclosed methods include a preparing step, including induction heating at least a portion of an aluminum alloy (AA) product and optionally quenching the induction heated AA product. After the preparing step, the methods include one of a contacting step and a bonding step. The contacting step includes contacting the at least a portion of the AA product with one of: a deoxidizing agent and a functionalization solution, where between the preparing and contacting steps the method is absent of any surface oxide treating steps of the AA product. The bonding step includes bonding the at least a portion of the AA product with a second material, thereby creating an as-bonded AA product, where between the preparing and bonding steps the method is absent of any surface oxide treating steps of the AA product. The methods may be employed to produce AA products for structural adhesive bonding applications.
Patent CA-3049478-A1 (CA)
Title: Process for manufacturing a power electronic module by additive manufacturing, associated module and substrate
Inventor: KHAZAKA RABIH
IPC: H05K1/02
Filed: 2018-01-05
Abstract: A process for manufacturing a power electronic module (20) by additive manufacturing, the electronic module (20) comprising a substrate (21) including an electrically insulating sheet (24) having first and second opposite faces (24a, 24b), and a first metal layer (25a) that is placed directly on the first face (24a) of the insulating sheet (24) and a second metal layer (25b) that is placed directly on the second face (25b) of the insulating sheet (24). At least one of the metal layers (25a) is produced via a step (100) of depositing a thin copper layer and a step (110) of annealing the metal layer (25a, 25b), and the process furthermore comprises a step (120) of forming at least one thermomechanical transition layer (271 to 273, 274 to 276) on at least one of the first and second metal layers (25a, 25b), said at least one thermomechanical transition layer (271 to 273, 274 to 276) including a material having a thermal expansion coefficient lower than that of the metal of the metal layer (25a, 25b).
Patent CA-3051453-A1 (CA)
Inventor: PILLALAMARRI SUNIL K
IPC: C09J175/04
Filed: 2018-03-09
Abstract: L'invention comprend une composition adhésive thermofusible réactive comprenant un prépolymère à fonction isocyanate dérivé d'un polyfonctionnel. L'isocyanate ayant une fonctionnalité d'environ 2 ou plus et un polyol, un silane organofonctionnel à hydrogène actif, un agent de coiffage non silane à base d'hydrogène actif et un polymère thermoplastique.