baber/WOPTO huggingface dataset:
Patent AU-670329-B2 (AU)
Title: New derivatives of erythromycin, their preparation process, their use as medicaments
Inventor: AGOURIDAS CONSTANTIN
IPC: A61K31/7042
Filed: 1993-11-05
Granted: 1996-07-11
Abstract: The subject of the invention is the compounds of formula (I): <IMAGE>  in which,   . either R represents a radical (CH2)nAr1, n representing an integer between 1 and 6, Ar1 representing: - either a substituted carbocyclic aryl radical, or an optionally substituted heterocyclic aryl radical, . or R represents a radical XAr2, in which X is an alkyl radical interrupted by O, S, SO, SO2, <IMAGE> -C-NH, Ar2 being an optionally substituted aryl or heteroaryl radical,  Z representing a hydrogen atom or the residue of an acid.   The compounds of formula (I) have valuable antibiotic properties.
Patent AU-629619-B2 (AU)
Title: Substituted 2-propenyl derivatives of nitrogen heterocycles
Inventor: LAI HOI K
IPC: C07D295/096
Filed: 1990-02-27
Granted: 1992-10-08
Abstract: A heterocyclic compound having the structural formula  <IMAGE>  where R is C1-C8 alkyl, C3-C6 cycloalkyl, trifluoromethyl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, benzyl or substituted benzyl; and R1 is at least a partially saturated monocyclic or bicyclic heterocycle of nitrogen which may be substituted with lower alkyl and physiologically acceptable salts thereof is disclosed. A process for forming this compound which involves the reaction of an amine of the formula HR1 where R1 has the meanings given above with a substituted 2-propenyl halide having the structural formula  <IMAGE>  where R has the meanings given above; and X is a halogen atom is described. The invention embodies the above-mentioned novel 2-propenyl halide utilized as an intermediate in the formation of the heterocyclic compound of this invention. A method ofcontrolling phytopathogenic fungi by applying a fungicidally effective amount of the heterocyclic compound of the present invention to the locus under attack by said fungi is also taught. Finally, a fungicidally composition comprising the heterocyclic compound of the present invention and a suitable carrier therefor is set forth.
Patent AU-694342-B2 (AU)
Title: 15-deoxyspergualin analogs, their method of preparation and their use in therapeutics
Inventor: LEBRETON LUC
IPC: A61K31/27
Filed: 1996-05-06
Granted: 1998-07-16
Abstract: 15-Deoxy-spergualin carbamate analogues of formula NH2-C(=NH)NH(CH2)6ACH2NHCO-O-(CH2)4NH(CH2)2-*CH(R)-NH2</ SB> (I) and their addn. salts are new. A=CONH or NHCO; R=H or Me; if R is other than H, *C has (R,S) or (R) configuration. Intermediates of formulae NHR1-C(=NR1)NH(CH2)6ACH2NHCO-O-(CH2)4N(R1)(CH2) 2-*CH(R)-NHR1 (II) and HO-(CH2)4-NR1-(CH2)2-*CH(R)-NHR1 (III; R=Me) are also new.
Patent AU-668456-B2 (AU)
Title: Method and device for automatic injection of an additive into the fuel tank of a motor vehicle
Inventor: LEMAIRE JACQUES
IPC: B01F3/08
Filed: 1994-02-23
Granted: 1996-05-02
Abstract: The invention relates to the automatic injection of an additive into the fuel tank of a motor vehicle, from an on-board additive tank. According to the invention, the quantity of additive to be withdrawn from the additive tank (101) is calculated using an on-board computation unit (102), and the quantity of additive thus calculated is injected by pulsed spraying, this spraying being carried out directly into the liquid bulk of fuel. This pulsed spraying is preferably carried out by controlling a piston positive-displacement pump (112), with a number of piston strokes which is automatically determined as a function of the quantity of additive to be withdrawn.   <IMAGE>
Patent AU-581303-B2 (AU)
Title: Method for the control of dust using methacrylate containing emulsions and compositions
Inventor: KIRWIN ROSS C
IPC: C08L33/10
Filed: 1986-03-27
Granted: 1989-02-16
Abstract: A method for suppressing dust comprises contacting a dust-producing material with an aqueous emulsion of a methacrylate polymer or a composition comprising a hydrophobic liquid and a methacrylate polymer. These emulsions and compositions may further comprise a wetting/penetration surfactant.
Patent AU-669960-B2 (AU)
Title: Novel cytokine designated elk ligand
Inventor: LYMAN STEWART
IPC: C12P21/08
Filed: 1993-11-15
Granted: 1996-06-27
Abstract: Antibodies to elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.
Patent AU-619986-B2 (AU)
Title: Processes for tigogenin beta-cellobioside
Inventor: URBAN FRANK JOHN
IPC: A61P9/10
Filed: 1990-06-12
Granted: 1992-02-06
Abstract: Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials, and novel intermediates useful in this process.
Patent AU-770530-B2 (AU)
Title: Process for the production of N-protected azetidine-2-carboxylic acids (AzeOHs)
Inventor: SJOGREN MAGNUS
IPC: C07D205/04
Filed: 1999-08-27
Granted: 2004-02-26
Abstract: There is provided a process for the production of a N-protected azetidine-2-carboxylic acid, which process comprises the steps of: (a) addition of base to an aqueous solvent comprising an organic acid addition salt of an azetidine-2-carboxylic acid; and (b) addition of protecting agent to the resultant reaction mixture.
Patent AU-609377-B2 (AU)
Title: New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them
Inventor: CLEMENCE FRANCOIS
IPC: C07D491/04
Filed: 1986-07-24
Granted: 1991-05-02
Abstract: Compounds of formula (I): <IMAGE> in which X at 5, 6, 7 or 8 is H, halogen, (C1-5) alkyl, (C1-4) alkoxy, -CF3, -SCF3, -OCF3, R1 is phenyl optionally substituted by at least OH, (C1-5) alkyl, (C1-4) alkoxy, CF3, NO2, halogen or a heterocyclic radical optionally substituted by a (C1-4) alkyl radical, R2 and R3 which are identical or different are H, (C1-4) alkyl, aryl, -C(:O)-R5, R5 being (C1-4) alkyl or aryl. R4 is H, (C1-4) alkyl or aryl, and their addition salts with acids and bases.
Patent AU-703007-B2 (AU)
Title: Salt-stabilized enzyme preparations
Inventor: HARZ HANS-PETER
IPC: A23K20/189
Filed: 1996-07-26
Granted: 1999-03-11
Abstract: The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extend an inorganic salt, e.g. MgSO4, is dissolved in an enzyme containing solution which is subsequently dried, using e.g. spray drying. Not only does the addition of salt improve the yield of enzyme activity upon drying, also the storage and processing stability of the obtained solid composition containing the enzyme and the inorganic salt are improved with respect to enzyme activity. The invention further discloses solid compositions comprising enzymes and inorganic salts.
Patent AU-735107-B2 (AU)
Title: Automated immunoassay cassette
Inventor: JONES RONALD M
IPC: G01N33/543
Filed: 1998-02-18
Granted: 2001-06-28
Abstract: The invention relates to an immunoassay cassette useful for carrying out multistage immunoassays in an automated manner. In operation, the cassette assumes different operational positions in which solutions are transferred sequentially across an absorbent pathway containing assay reagents.
Patent AU-532981-B2 (AU)
Title: Drive control for an elevator
Inventor: SCHRODER JORIS
IPC: B66B1/16
Filed: 1980-09-26
Granted: 1983-10-20
Abstract: A drive control for transportation systems, especially elevators or the like, improves the stopping accuracy of the elevator cabin at a storey or floor of the building. A reference value transmitter operated by a digital computer produces step-like successive travel curves and displacement path-reference values operatively associated with such travel curves and feedable to a regulation circuit. Connected with the reference value transmitter is a stop initiation device, which during initiating the stop or halting of the elevator, forms from a possible target path produced by the reference value transmitter and a target path corresponding to a target storey a target error. This target error is infed to a stop correction device connected with the reference value transmitter and the stop initiation device, which while utilizing the target error modifies by interpolation the travel curve which is to be produced by the reference value transmitter in a manner such that there is available for regulation an optimum travel curve to the target storey. An arrival correction device which further improves the halt or stop accuracy of the elevator, forms from the elevator cabin site determined at a cabin displacement path counter and the storey site of the target storey a difference which, for the purpose of further correction of the displacement path-reference value, is infed to the stop correction device. This drive control, apart from being used with elevator systems, for instance also can be employed for track-bound horizontal systems.
Patent AU-540500-B2 (AU)
Title: Hemispherically domed combustion chamber and rocker mechanism for valves therefor
Inventor: GAVASSO JOHN MICHALE
IPC: F02B23/00
Filed: 1980-12-31
Granted: 1984-11-22
Abstract: An engine constructed with a hemispherically shaped combustion chamber (40) having inlet (66) and exhaust valves (68) flush mounted in the surface (38) of the chamber (40) with centerlines (73) perpendicular to the chamber surface (38) and intersecting the cylinder bore centerline (76) at a common point (78); the valve train components for each valve all acting in a single plane (116) and having centerlines (72, 110 and 112) that together converge towards a common point (114) adjacent the cylinder bore enterline (76), the valve train planes (116) of each pair of inlet (66) and exhaust valves (68) being canted with respect to each other and to the camshaft axis (118), a single overhead camshaft (104) being centrally located between the inlet and exhaust valves 66 and 68.
Patent AU-778720-B2 (AU)
Title: Substituted benzylthiazolidine-2,4-dione derivatives
Inventor: MIYACHI HIROYUKI
IPC: A61P43/00
Filed: 2000-08-18
Granted: 2004-12-16
Abstract: The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives that bind to receptor to activate as ligands of human peroxisome proliferator-activated receptor (PPAR) and exhibit blood glucose-decreasing action and lipid-decreasing action, and processes for preparing them. It relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) <CHEM> Äwherein the bond mode of A denotes -CH2CONH-, -NHCONH-, -CH2CH2CO- or -NHCOCH2-, and B denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, halogen atom, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituentsÜ, their medicinally acceptable salts, their hydrates and processes for preparing them.
Patent AU-743539-B2 (AU)
Title: Device for controlling a liquid flow
Inventor: BOUWKAMP GERTJAN ROELOF
IPC: E02B7/18
Filed: 1998-02-23
Granted: 2002-01-31
Abstract: A device for controlling a liquid flow by means of a gas pressure. The device comprises a pressure chamber (5), in which an overpressure, an underpressure or atmospheric pressure may prevail. The pressure in said pressure chamber (5) can be used for allowing the liquid flow to pass or for stopping said liquid flow. Furthermore the liquid flow can be limited to a predetermined rate of flow. The device may inter alia be used in sewage systems, hydraulic engineering works and irrigation works. <IMAGE>
Patent AU-638303-B2 (AU)
Title: Cyclopropyl derivative lipoxygenase inhibitors
IPC: A61K31/5375
Filed: 1990-12-21
Granted: 1993-06-24
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
Patent AU-693449-B2 (AU)
Title: 5-HT4 receptor antagonists
Inventor: KING DAVID FRANCIS
IPC: C07D498/04
Filed: 1994-05-16
Granted: 1998-07-02
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: <?in-line-formulae description="In-line Formulae" end="lead"?>X-CO-CH<SUB>2</SUB>-Z <?in-line-formulae description="In-line Formulae" end="tail"?> wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), (j) or (k): wherein n<SUP>1 </SUP>is 1, 2, 3 or 4; n<SUP>2 </SUP>is 0, 1, 2, 3 or 4; n<SUP>3</SUP>is 2, 3, 4 or 5; q is 0, 1, 2 or 3; p is 0, 1 or 2; m is 0, 1 or 2; R<SUB>5 </SUB>is hydrogen, C<SUB>1-2 </SUB>alkyl, aralkyl or R<SUB>5 </SUB>is (CH<SUB>2</SUB>)<SUB>z</SUB>-R<SUB>10 </SUB>wherein z is 2 or 3 and R<SUB>10 </SUB>is selected from cyano, hydroxyl, C<SUB>1-6 </SUB>alkoxy, phenoxy, C(O)C<SUB>1-6 </SUB>alkyl, COC<SUB>6</SUB>H<SUB>5</SUB>, -CONR<SUB>11</SUB>R<SUB>12</SUB>, NR<SUB>11</SUB>COR<SUB>12</SUB>, SO<SUB>2</SUB>NR<SUB>11</SUB>R<SUB>12 </SUB>or NR<SUB>11</SUB>SO<SUB>2</SUB>R<SUB>12 </SUB>wherein R<SUB>11 </SUB>and R<SUB>12 </SUB>are hydrogen or C<SUB>1-6 </SUB>alkyl; or R<SUB>5 </SUB>is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, C<SUB>2-7 </SUB>alkoxycarbonyl, or secondary or tertiary hydroxy substituted C<SUB>1-6 </SUB>alkyl; ; and R<SUB>6</SUB>, R<SUB>7 </SUB>and R<SUB>8 </SUB>are independently hydrogen or C<SUB>1-6 </SUB>alkyl; and R<SUB>9 </SUB>is hydrogen or C<SUB>1-10</SUB>alkyl; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
Patent AU-740387-B2 (AU)
Title: Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
Inventor: CARDOSO JOAQUIM P
IPC: C12P17/18
Filed: 1998-03-20
Granted: 2001-11-01
Abstract: The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction of the clavulanic acid to a water immiscible or partly water immiscible solvent at pH from 1.2 - 2, precipitation of an alkali metal salt A of clavulanic acid by addition of a solution of an alkali metal alkylalkanoate, characterized by the following steps:   before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5 for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated.
Patent AU-596838-B2 (AU)
Title: Remote administration of hyaluronic acid to mammals
Inventor: SCHULTZ RICHARDT H
IPC: A61P29/00
Filed: 1987-04-15
Granted: 1990-05-17
Abstract: The present disclosure is concerned with the discovery that hyaluronic acid, an agent well known to reduce the sequelae of trauma in mammalian joint tissue when applied directly to the traumatized tissue, will be carried to such traumatized tissue by the mammal's natural processes if applied at a site remote from the traumatized tissue. Thus, hyaluronic acid, in any therapeutically acceptable form, can be administered by the typical remote routes including intravenous, intramuscular, subcutaneous and topical. This makes the utilization of hyaluronic acid much more convenient and attractive. For instance the treatment of arthritis in horse or human joints with hyaluronic acid no longer requires more difficult intra articular injections.
Patent AU-743525-B2 (AU)
Title: Methods for production of hybrid wheat
Inventor: FELDMAN MOSHE
IPC: A01H5/00
Filed: 1998-05-14
Granted: 2002-01-31
Abstract: The present invention provides a method for the production of hybrid wheat based on the ability to stably maintaining a genic male-sterile female parental line of common and durum wheat It also provides a male-sterile female line homozygous for a recessive male-sterility allele and for a dominant pollen-killing allele, and a maintainer line which is readily and stably propagated. The maintainer line is isogenic to the female line but has an alien engineered chromosome carrying a dominant male-fertility allele that restores fertility to the maintainer line, a recessive pollen-killing allele that is susceptible to the killing effect of the native pollen killer thus preventing transmission of this chromosome to the female line, and one or more selectable markers that facilitate the maintenance of the maintainer itself. The invention also provides procedures for converting any desired cultivar into male-sterile female line and into a maintainer line.
Patent AU-596855-B2 (AU)
Title: A pack for flowable material
Inventor: RAUSING HANS DR
IPC: B65D8/22
Filed: 1987-07-22
Granted: 1990-05-17
Abstract: A pack for flowable material, includes a tube (1) having at least one longitudinal seam, with a base and a lid (2) mounted at its ends. The lid (2) is made of thermoplastics material without any base material, is welded to the tube (1) and has a pouring device (8). The tube (1) is made of base material such as cardboard, coated with thermoplastics material on at least one side. The lid (2) is a separate, prefabricated part fitted by means of a flange (5) engaging round the top edge (6) of the tube (1) and welded to the edge (6). This lid (2) has a part (21) of its surface at a lower level than its outer surface, with part of the lower level surface (21) extending near to the edge (6) of the tube, in such a way that the lid (2) engages round the edge (6) of the tube substantially in a U shape in the region of said part (21 ) of the lower level surface.
Patent AU-708881-B2 (AU)
Title: Preparation for substitution therapy, containing at least one progestogen and at least one estrogen
Inventor: KONINCKX PHILIPPE ROBERT MARIE
IPC: A61K31/57
Filed: 1994-09-08
Granted: 1999-08-12
Abstract: PCT No. PCT/EP94/02997 Sec. 371 Date Jun. 4, 1996 Sec. 102(e) Date Jun. 4, 1996 PCT Filed Sep. 8, 1994 PCT Pub. No. WO95/07081 PCT Pub. Date Mar. 16, 1995The invention relates to a preparation for substitution therapy and oral contraception comprising at least one progestogen and at least one estrogen in which the estrogen dose varies with a periodicity such that blood loss is substantially avoided, wherein the periodicity is preferably less than 10 days, more preferably less than 7 days, such as preparations containing the progestogen and/or estrogen in an oral, transdermal, parenteral and/or implantable application form.
Patent AU-738817-B2 (AU)
Title: Evaporative cooling condensation type ammonia refrigeration unit
Inventor: SAKASHITA SHIGERU
IPC: F25B39/04
Filed: 1998-07-09
Granted: 2001-09-27
Abstract: An evaporative-cooling condensation type ammonia refrigeration unit with leaked ammonia gas removing means is provided. Recovery of a leaked ammonia gas is conducted taking advantage of a high solubility of ammonia in water, wherein the leaked ammonia gas is dissolved in a cooling water used for an evaporative condenser. The construction of the unit is characterized by including an ammonia absorptive structure in a gas/liquid countercurrent mode provided in a space on the lower side of the evaporative condenser accommodated in an upper chamber. <IMAGE>
Patent AU-737587-B2 (AU)
Title: Improved processes for making surfactants via adsorptive separation and products thereof
Inventor: CONNOR DANIEL STEDMAN
IPC: C09K23/12
Filed: 1998-08-04
Granted: 2001-08-23
Abstract: Processes for making particularly branched, especially monomethyl-branched or nongeminal dimethyl-branched surfactants used in cleaning products; preferred processes comprising particular combinations of two or more adsorptive separation steps and, more preferably, particular alkylation steps; products of such processes, including certain modified alkylbenzenes, modified alkylbenzenesulfonate surfactants, and consumer cleaning products, especially laundry detergents, containing them. Preferred processes herein more specifically use specific, unconventional sequences of sorptive separation steps to secure certain branched hydrocarbon fractions which are used in further process steps as alkylating agents for arenes or for other useful surfactant-making purposes. Surprisingly, such fractions can even be derived from effluents from current linear alkylbenzene manufacture.
Patent BG-61056-B2 (BG)
Inventor: MELLONI PIERO
IPC: C07C41/16
Filed: 1994-02-22
Abstract: Съединенията намират приложение в медицината катоантидепресанти. Имат обща формула, в която заместителите имат посочените в описанието значения.
Patent DE-1931242-B2 (DE)
Title: Sample and hold circuit for analogue signals - generates "staircase" representation using two relays with short and long time constants
IPC: G11C27/02
Filed: 1969-06-20
Abstract: An analogue signal is sampled by relays operated by a clock signal to generate a 'staircase' digitised version of the signal with a controlled delay. The output from an catalogue signal generator (G1) e.g. a sine wage is transmitted over a first relay (T1) coupled to a capacitor (C1) and isolating amplifier (V1). The output voltage is transmitted to a second stage consisting of a relay (T2) capacitor (C2) and amplifier (V2). The first stage provide accurate sampling with a short hold time constant. The second stage has a long time constant and provides a relatively long hold time. In this way the two stages operate to provide precise amplitude coupled with a long hold period.
Patent DE-2033510-B2 (DE)
Title: Coding of bipolar analog pick=up values - using two alternately active comparators, each receiving pick=up value at inputs, second comparator input being inverted
IPC: H03M1/00
Filed: 1970-07-07
Abstract: The pick-up values are of any arbitrary polarity and are processed a feedback coder, using unipolar comparison voltages. Each value (E) is fed to an input (E11) of a first comparator (V1) without change, and in an inverted form to a input (E21) of a second comparator (V2). The unipolar comparison voltages are fed to the second inputs (E12, E22) of both comparators. The comparators are controlled by two inverse signals of a bistable flip-flop (K), via their third inputs (E13, E23) into effective or blocking state respectively. The flip-flop state, prior to coding, is controlled in dependence on a clock pulse signal and an output signal of one comparator. The effective comparator transmits a signal ony when the pick-up value has the same polarity, and greater value, than the comparison voltage. Both comparator output signals are transmitted via a common output.