Patent SG-11201903830T-A (SG)
Title: Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
Inventor: CAMPANA DARIO
IPC: C12N5/10
Filed: 2017-11-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/098306 Al 31 May 2018 (31.05.2018) WIPO I PCT (51) International Patent Classification: Declarations under Rule 4.17: C12N 5/0783 (2010.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) — as to applicant's entitlement to apply for and be granted a A61K 35/17 (2015.01) patent (Rule 4.17(ii)) — as to the applicant's entitlement to claim the priority of the (21) International Application Number: earlier application (Rule 4.17(iii)) PCT/US2017/063048 Published: (22) International Filing Date: — with international search report (Art. 21(3)) 22 November 2017 (22.11.2017) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/425,398 22 November 2016 (22.11.2016) US 62/543,696 10 August 2017 (10.08.2017) US (71) Applicant: NATIONAL UNIVERSITY OF SINGA- PORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: CAMPANA, Dario; 24 Everton Road, Sin- gapore 089379 (SG). VINANICA, Natasha; 969 Bukit Timah Road #09-18, Singapore 589664 (SG). KAMAYA, Takahiro; 1-16-8-1004, Botan, Koto-ku, Tokyo, 135-0046 (JP). PNG, Yi, Tian; Block 405 Woodlands Street 41 #10-42, Singapore 730405 (SG). (74) Agent: NG, Jennifer; MORGAN LEWIS & BOCKIUS LLP, One Market, Spear Street Tower, San Francisco, CA 94105 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ,tD 0 KM, ML, MR, NE, SN, TD, TG). M GC 01 0 --.... 00 1-1 (54) Title: BLOCKADE OF CD7 EXPRESSION AND CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY OF T- 0 el CELL MALIGNANCIES C (57) : The present invention provides compositions comprising an anti-CD7 chimeric activating receptor (CAR) and an an- ti-CD7 protein expression blocker, and methods of using such compositions in cancer therapy.