baber/WOPTO huggingface dataset:
Patent PT-783307-E (PT)
Inventor: BERNARD BRUNO
IPC: A61K31/513
Filed: 1995-09-19
Abstract: PCT No. PCT/FR95/01197 Sec. 371 Date Jun. 9, 1997 Sec. 102(e) Date Jun. 9, 1997 PCT Filed Sep. 19, 1995 PCT Pub. No. WO96/09048 PCT Pub. Date Mar. 28, 1996The Use of 2,4-diamino pyrimidine 3-oxide or a physiologically acceptable salt thereof as the active substance for the preparation of a therapeutical composition is disclosed. Said therapeutical composition is useful for treating collagen maturation and structuring disorders.
Patent PT-768309-E (PT)
Inventor: MEIJ PAULUS FRANCISCUS CORNELI
IPC: A61P43/00
Filed: 1996-10-10
Abstract: The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula <CHEM>  wherein:     n is 0 or 1;   m is 1 or 2;   R1 is hydrogen, methyl or ethyl; and   C* denotes a chiral centre;  as well as its pharmaceutically acceptable acid addition salt; by   a) adding a carboxylic acid in an optically active form to a solution of a racemic mixture of the above compound I, followed by separation of the crystallized acid addition salt of said mixture of enantiomers of compound I enriched in one enantiomer, from the mother liquor enriched in the other enantiomer b) when the crystallized acid addition salt is enriched in the undesired enantiomer, by then separating the mixture of enantiomers in the mother liquor from said optically active carboxylic acid, followed by addition of a racemic mixture of said carboxylic acid to a solution of the obtained mixture of isomers of I, and by separation of the crystallized acid addition salt of said mixture, enriched in the desired enantiomer, from the mother liquor, and (c) optionally recrystallizing the product until the desired enantiomeric purity is obtained, and by then (d) converting this acid-addition salt of the desired enantiomer to the desired enantiomerically pure imidazolyl compound of the general formula I or to its pharmaceutically acceptable acid addition salt, characterized in that pyroglutamic acid is used as said carboxylic acid. The invention further relates to a method of racemisation and to a new acid addition salt of this formula I compound and D-pyroglutamic acid.
Patent PT-738657-E (PT)
Inventor: GUARDIOLA AGUSTIN DAUDER
IPC: B65B25/04
Filed: 1996-04-16
Abstract: A machine for obtaining bags full of products from batches of tubular net (9), which comprises at least a vertical tube (1), a turning support (2) for said tube and a framework (4) with two arms (10,11) swinging on a vertical plane, the ends of which arms are fitted with two pairs of conical wheels, turning in opposite directions and applicable against the wall of the tube, with the tubular net in between. <IMAGE>
Patent PT-851996-E (PT)
Inventor: GERRISH PHILIP
IPC: F26B3/34
Filed: 1996-09-12
Abstract: PCT No. PCT/GB96/02250 Sec. 371 Date Apr. 16, 1998 Sec. 102(e) Date Apr. 16, 1998 PCT Filed Sep. 12, 1996 PCT Pub. No. WO97/10482 PCT Pub. Date Mar. 20, 1997Timber drying apparatus comprises a housing defining a microwave cavity (4) for containing a quantity of timber, a microwave generator (1) coupled to the housing for introducing microwave energy into the cavity, temperature sensing means (13) arranged to sense the temperature of timber within the cavity and/or weight sensing means (8) for sensing the weight of timber within the cavity and control means for varying the power output of the microwave generator in response to the sense temperature and/or weight. The humidity and/or air temperature may also be sensed in the cavity. The timber may be oscillated within the cavity.
Patent PT-888127-E (PT)
Inventor: GREGORY SUSAN A
IPC: H01M4/80
Filed: 1997-02-12
Abstract: This invention is in the field of a combination comprising a therapeutically-effective amount of a cyclooxygenase-2 inhibitor, a 5-lipoxygenase inhibitor and an immunosuppressive drug selected from antiproliferative agents, antiinflammatory-acting compounds and inhibitors of leukocyte activation. This combination may be used, for example, to suppress the immune response associated with organ transplantation, graft versus host disease, and conditions with underlying autoimmune or inflammatory reactivities or responses.
Patent PT-835112-E (PT)
Inventor: KEPPLER BERNHARD K
IPC: A61K31/555
Filed: 1997-04-01
Abstract: The invention concerns complex compounds of general formula (I) {G}<-(n+p+2r(p-1)-3)>{[RuX6-n-p-q-2rBn(H2O)p(OH)q(O)r]2r+1}<n+p+2r(p-1)-3>, in which: n+p+2r(p-1)-3q NOTEQUAL 0; G is a suitable counterion but not a charged heterocycle; B is a mono- or polynuclear basic heterocycle with one or a plurality of nitrogen atoms; X represents halides, pseudohalides, HCO3-, RCOO-, in which R is C1-C6 aryl, alkenyl or alkyl (substituted or unsubstituted); n is 1, 2 or 3, but n+p NOTEQUAL 3; p is either 0 or 1, or 0 or 0.5p if r = 0.5; q is either 0 or 1, or 0 or 0.5q if r = 0.5,  SIGMA  n, p, q</=6; and r is 0 or 0.5. These compounds have a tumour-inhibiting effect with good solubility in water and are therefore suitable as chemotherapy agents for treating cancers.                                  00000
Patent PT-914472-E (PT)
Title: Method for typing and detecting hbv
Inventor: ROSSAU RUDI
IPC: C12N15/36
Filed: 1997-04-21
Abstract: The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT pol gene region and/or to a mutant target sequence chosen from the HBV preCore region and/or to a mutant target sequence chosen from the HBsAg region of HBV and/or to a HBV genotype-specific target sequence, with said target sequences being chosen from Figure 1, and with said probes being applied to known locations on a solid support and with said probes being capable of hybridizing to the polynucleic acids of the sample under the same hybridization and wash conditions, or with said probes hybridizing specifically with a sequence complementary to any of said target sequences, or a sequence wherein T of said target sequence is replaced by U; and detecting the hybrids formed; and inferring the HBV genotype and/or mutants present in said sample from the differential hybridization signal(s) obtained.  The invention further relates to sets of nucleotide probes and possibly primers useful in said methods as well as to their use in a method for typing and/orp detecting HBV and to assay kits using the same.
Patent PT-964687-E (PT)
Inventor: NESZMELYI ERZSEBET
IPC: A61K33/24
Filed: 1997-09-11
Abstract: The invention relates to pharmaceutical compositions of antimicrobial effect as well as a process for the preparation thereof. The pharmaceutical compositions of the invention comprise zinc or cobalt hyaluronate associate (complex) as active ingredient in admixture with a carrier and/or other additives commonly used in the pharmaceutical industry.
Patent PT-1029297-E (PT)
Inventor: HORVATH DRAGOS
IPC: G16C20/64
Filed: 1998-11-04
Abstract: The method to rapidly retrieve potentially active analogs of lead compounds according to the invention generates and screens from a large database of 3D multiconformational fingerprints of chemically feasible combinatorial products mainly by modeling the radicals by linking them temporarily to a bulky spacekeeper group, registering such 3D models of the radicals in a combinatorial ghost database, for any molecular structure that is accessible within the ghost database, detecting any atom that displays physical property features of the pharmacophoric type; for the pharmacophores (BPs) detected in each molecular structure, calculating all the distances between the involved atoms in every conformation of this molecule and creating a BP distance distribution density; generating a conformational fingerprint vector that contains all the distance distribution densities of the pharmacophores (BPs); defining a scoring function for each molecular fingerprint accounting for the relative importance of the pharmacophoric features; and comparing these fingerprints to each fingerprint of the potential library according to the above scoring function as maximized for the lead, and retrieving the molecules of the potential library for which the scoring function gives score values less than a specified threshold. <IMAGE>
Patent SG-33189-G (SG)
Title: Cutter head for dry shavers
IPC: B26B19/04
Filed: 1989-05-22
Abstract: In a shaving head for dry shavers with a shaving head frame removably disposed on the shaver housing in an interchangeable frame insertable therein, in which a shaving foil cooperating with a reciprocating cutting head is convexly tensioned, the interchangeable frame is positively locked directly to the shaver housing.
Patent SG-95692-G (SG)
Title: Process for the preparation of a basic salt,salt thus prepared and oil compositions containing such a salt
IPC: C07C57/13
Filed: 1992-09-24
Abstract: Process for the preparation of basic alkaline earth metal salts of organic carboxylic acids, which comprises   (a) blending an oil-soluble alkyl salicylic acid with one or more long-chain hydrocarbon substituted derivatives of succinic acid or anhydride, in which the hydrocarbon substituent has a number average molecular weight from 120 to 5000, (b) mixing the blend of acid with more than an equivalent amount of an alkaline earth metal hydroxide and/or oxide in a hydrocarbon solvent; (c) introducing carbon dioxide into the mixture obtained in an amount of at least 0.5 equivalent carbon dioxide per equivalent of excess alkaline earth metal; and (d) removing residual solids, if any, and an aqueous layer, if any.
Patent IE-36061-L (IE)
Title: PREPARATION OF 10, 11-DIHYDRODIBENZO [b,f] AZEPINONE.
IPC: C07D223/22
Filed: 1972-01-17
Abstract: 1328602 10,11 - Dihydro - dibenzo[b,f]azepinones RHONE-POULENC SA 18 Jan 1972 [19 Jan 1971] 2425/72 Heading C2C A process for the preparation of 10,11-dihydrodibenzo[b,f]azepinones of Formula I in which R 1 is C 1-5 alkyl, a phenalkyl (in which alkyl portion contains 1 to 5 C atoms and the phenyl nucleus is unsubstituted or substituted by one or more halogen atoms, C 1-5 alkyl groups, C 1-5 alkoxy groups or trifluoromethyl groups) or a radical A-NR 2 R 3 in which A is an alkylene radical of 2 to 6 C atoms and R 2 and R 3 which may be identical or different are C 1-5 alkyl or one of the radicals R 2 and R 3 may be attached to a C atom of the alkylene chain to form a heterocyclic ring or both radicals R 2 and R 3 with the N atom may form a 5 or 6 membered heterocyclic ring which may additionally contain a N, O or S atom and which may be unsubstituted or substituted by one or more C 1-5 alkyl groups and when R 1 is A-NR 2 R 3 their acid addition salts, comprises cyclizing an ester of Formula II in which R<SP>1</SP> is C 1-5 alkyl in the presence of at least one mole of hexamethyl-phosphotriamide per mole of ester and an alkali metal amide R 4 R 5 -N-M in which M is an alkali metal atom (preferably lithium) and R 4 and R 5 which may be the same or different are each C 1-5 alkyl or form together with the N atom a 5 or 6- membered heterocyclic ring which may contain an additional hetero-atom. The reaction takes place in an inert organic solvent (preferably benzene) at a temperature of 20-40 C. with 4 to 6 moles of amide per mole of ester.
[GB1328602A]
Patent IE-780441-L (IE)
Title: 7-oxo-ó-phenyl-4-oxa-2, 6-diazabicyclo [3,2,0]¹hept-2-ene-6-acetic acid ester derivatives
IPC: C07D498/04
Filed: 1978-03-03
Abstract: 1-[ alpha -(Carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one esters are prepared by converting 2-acyl-3,3-dialkyl-7-oxo- alpha -[4-(benzyloxy)phenyl]-4-thia-2,6-diazabicyclo[3.2.0]-heptane-6-acetic acid esters with mercuric acetate in an aqueous organic solvent mixture, e.g., in aqueous methanol, to 7-oxo-3-phenyl- alpha -[4-(benzyloxy)phenyl]-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-ene-1-acetic acid esters and the latter are reacted with PCl5 and pyridine to provide the monocyclic 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -( alpha -chlorobenzylideneamino)-4-chloroazetidin-2-one esters. Reduction of the dichloro azetidin-2-one with an organo tin hydride and azobisisobutyronitrile affords the deschloro, 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -benzylideneaminoazetidin-2-one ester. The latter is hydrolyzed and the 4-benzyloxy group is cleaved via catalytic hydrogenolysis to yield an ester of 1-[ alpha -(carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one. The 3 beta -amino ester is useful for the preparation of the antibiotic FR 1923 (nocardicin).
[US4127568A]
Patent IE-34681-L (IE)
Title: Protecting and/or stabilising an inclined face
IPC: E02D17/20
Filed: 1970-04-10
Abstract: 1341957 Soil stabilisation revetments L E GREGORY 9 Dec 1970 [24 Dec 1969] 62773/ 69 Headings E1F and E1H [Also in Division A1] An inclined earth or rock face is stabilised by lattice work comprising cables, extending down the face and tensioned between anchorages, and connected to rows of troughs extending across the face which receive material to form a new face. Parallel cables 12, anchored tend down the face and are anchored to piles in concrete 15 and bearing on pads 18, ex- 20. Material 22 is placed into and between rows of troughs 21 to form new face 23. Troughs 21 are of channel-shaped cross-section, and in each trough row each pair of adjacent trough ends is seated in and connected to a connector of similar cross-section. A plate rises vertically from the connectors base, between the seated trough ends, the cables being attached by V-belts to the plates. The upper anchorage may comprise a cantilevered beam from which two or more sets of cables may be suspended to form layers of lattices above the original face. The lower ends of the cables may be anchored in concrete, possibly within a precast concrete structure. The lattice may be covered with concrete, where it extends beneath water, to form an erosion barrier. The cables may be anchored between their ends to the original face. The cables may be made of stranded steel wire which may be galvanised or plastics coated, or may be made of plastics material, e.g. nylon fibre. The connectors may be made of steel, aluminium alloy or a reinforced synthetic material.
[GB1341957A]
Patent IE-860592-L (IE)
Title: Cell jacket
IPC: H01M50/133
Filed: 1986-03-06
Abstract: A cell jacket comprised of adhered inner and outer protective layers which protect a metallic ink decoration contained therebetween from degradation. The protective layers are adhered to each other substantially completely around the periphery of the metallic ink decoration.
[US4608323A]
Patent IE-810735-L (IE)
Title: Coating metal
IPC: B05D3/00
Filed: 1981-03-31
Abstract: This invention relates to a pretreatment process for galvanized metal which, unlike existing processes, was specifically developed for galvanized metal. Because of the natural corrosion protection properties of the zinc cladding of galvanized metal, no additional passivation is necessary as is required with existing processes. Also, the invention relates to the galvanized metal which has been pretreated by the process of this invention prior to application of an organic powder coating. Galvanized metal treated by this pretreatment process prior to coating leads to a uniform coating which is impervious to acid, base and salt solutions, and which will not scratch or flake off on impact.
Patent IE-840875-L (IE)
Title: Dopamine-beta-hydroxylase inhibitors.
IPC: C07D233/56
Filed: 1984-04-10
Abstract: Compounds of formula 
<CHEM>
 wherein
 Y is -H, -OH, -OCH3, -F, -CF3 or C1-4alkyl;
 X is -H, -OH, -OCH3, -F, -CF3 or C1-4alkyl,
 or any accessible combination thereof up to four substituents;
 R is -CO2H or -CH2NHR<1>;
 R<1> is -H, phenyl or benzyl; and,
 n is 0-4,
 intermediates and processes for their preparation, pharmaceutical compositions containing them and their use in the inhibition of dopamine  beta -hydroxylase in mammals are described.
Patent IE-34398-L (IE)
Title: Azetidinones
IPC: C07D205/095
Filed: 1970-07-20
Abstract: 1,269,279. Azetidinones. BEECHAM GROUP Ltd. 20 July, 1970 [29 July, 1969], No. 37977/69. Heading C2C. Novel compounds I (including acid addition salts thereof and stereoisomers) where R is optionally substituted alkyl, aralkyl O alkenyl, R<SP>1</SP> is H, or optionally substituted alkyl, aralkyl or aryl or a salt forming ion, R<SP>2</SP> is H or optionally substituted aralkyl or acyl and R<SP>3</SP> is H or optionally substituted aralkyl, are made by reacting penicillanic acid derivatives (II), in anhydrous liquid medium, with a strong base which does not cleave the #-lactam ring, and with an alkylating, aralkylating or alkenylating agent to introduce R; II are such that the products I are those where R<SP>2</SP> is aralkyl (removal of aralkyl, e.g. trityl is conveniently removed utilizing p-toluene-sulphonic acid, affords I where R<SP>2</SP> is H; subsequent acylation affords I, where R<SP>2</SP> is acyl) and R<SP>1</SP> is alkyl, aralkyl or aryl (catalytic hydrogenation or hydrolysis accordingly affords the free acids I). The starting materials (II), e.g. benzyl and pmethoxybenzyl 6 - # - (triphenylmethylamino) penicillanates, are prepared, e.g. by the tritylation of the appropriate 6-aminopenicillanic acid esters.
[GB1269279A]
Patent FI-843626-L (FI)
Inventor: BERGMAN STEN G A
IPC: G21F9/24
Filed: 1984-09-17
Abstract: @ The present invention relates to a storage plant for storing radioactive material in rock formations, the plant comprising a cavity (4) for accommodating radioactive material, the cavity (4) having therearound a rock shield (6) in which a further cavity (7) is optionally formed, there being arranged in the optional cavity a barrier (8) comprising a resilient material which swells in water. Arranged around the second cavity (7) and spaced therefrom is a helical tunnel (12). Entry tunnels (13) extend from the helical tunnel (12), in towards the remaining parts (4, 7) of the plant. The invention is characterised in that at least one cage of substantially vertical drill holes (14) is arranged around the plant, preferably in connection with the helical tunnel (12), fortaking-up and conducting away water arriving at and departing from the inner part of the storage plant.
Patent FI-850325-L (FI)
Inventor: JONES GORDON H
IPC: A61K31/33
Filed: 1985-01-25
Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: <CHEM>  wherein: R<1> is alkoxy of one to twelve carbon atoms, of one to twelve carbon atoms, alkylthio of one to twelve carbon atoms, optionally substituted phenoxy or optionally substituted phenylthio; R<2> is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl; R<3> is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2, or R<3> is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O)nR wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.
Patent FI-850648-L (FI)
Inventor: BURT PETER
IPC: E04D1/28
Filed: 1985-02-15
Abstract: A method for the manufacture of roof tiles involves the introduction of tile material into a hopper 1 for subsequent depositing on a series of moving pallets 8, for forming a basic strip 11, which is cut into individual tiles 12. One or more pigments colouring the mass is added to the material before it is introduced into the hopper 1, for example in a screw conveyor 2, which runs to the hopper, and one or more secondary colour pigments are added to the material in the hopper 1 in order to obtain tiles with striped surfaces. <IMAGE>
Patent FI-851207-L (FI)
Inventor: ZIMMERMANN ANSO
IPC: A47J41/02
Filed: 1985-03-26
Abstract: The subject of the invention is an insulating jug having a protective housing in which there is arranged an insulating insert held between a housing top part and a housing bottom part, having a handle, an opening which is sealable by a lid and a pourer which passes radially out through a cut-out portion in the housing casing of the protective housing. The object of the invention is to stabilize the protective casing of the zones on both sides of the cut-out portion which are weakened by the cut-out portion for the pourer. This is achieved in that there are provided on both sides of the cut-out portion (17) on the facing surfaces (13, 21) of the protective casing (6) and of the housing top part (4) extensions or recesses (21, 22) which interlock with surfaces which extend transversely to the peripheral direction. According to an alternative solution, the edge (7) of the protective casing (6) on both sides of the cut-out portion (17) is encompassed on the inside and on the outside by lips (32) and projections (33) respectively of the housing top part (4) around an angle (W) of at least approximately 45 DEG  which is open to the cut-out portion (17).
Patent FI-851436-L (FI)
Inventor: GUMMELT KLAUS
IPC: H01M10/52
Filed: 1985-04-11
Abstract: The temperature rise associated with the catalytic recombination of battery gases at the end of the charging process is converted into an electrical signal suitable for checking and controlling charging, in a temperature-sensitive component such as a commercially available NTC or PTC resistor coated with a PTFE-bound palladium-activated carbon mixture. An additional activated carbon layer protects the catalyst from poisoning by the stibine present in the battery gases.
Patent IE-37876-L (IE)
Title: PREPARATION OF 2ß-HYDROXY-3Ó-AMINO-STEROIDS.
IPC: C07J71/00
Filed: 1973-07-04
Abstract: 1439605 2#-hydroxy or acyloxy-3α-amino or acylamino-steroids AKZO NV 10 July 1973 1973 [14 July 1972] 33112/72 Heading C2U Novel steroids of the formula wherein R 1 is H or CH 3 ; R 2 is C 1-4 alkyl; R 3 is H or acyl; X is H 2 , H (α- or #-OR 3 ) or O; and Y is O, H (#-OR 3 ), R 4 (#-OR 3 ), H (#-COCH 3 ) orH (#-CHOR 3 CH 3 ) in which R 4 is a saturated or unsaturated C 1-4 aliphatic hydrocarbon group, and their acid-addition salts, and the N-acyl derivatives thereof are prepared by reaction of the corresponding 2(3-hydroxy or acyloxy-3α- halo-steroids (prepared from the corresponding #<SP>2</SP>-steroids and hypohalous acids followed, when required, by 0-acylation) with ammonia; or by reaction of the same starting materials with alkali followed by reaction of the 25-3#-epoxysteroids thus produced (a) with ammonia, or (b) with an alkali metal azide followed by reduction of the 2#-hydroxy-3α-steroids thus produced, or (c) with benzylamine followed by hydrogenolysis of the 2#-hydroxy-3α-benzylamino steriods thus produced. Hydroxy groups may be acylated at any stage and the products may be N-acylated. Acid-addition salts may also be prepared. 17-Ketones may be reduced to the corresponding 17#-ols. The novel steroids are stated to be antiarrhythmic agents which are virtually devoid of convulsant and local anaesthetic activities and which have no CNS stimulating effects. They may be made up into pharmaceutical compositions with suitable carriers.
[GB1439605A]
Patent IE-36664-L (IE)
Title: Blending device.
IPC: A21C1/00
Filed: 1972-09-04
Abstract: 1402538 Mixing apparatus UNILEVER LTD 1 Sept 1972 [6 Sept 1971] 41395/71 Heading B1C Apparatus for homogenising or mixing liquids, powders or gases comprises a detachable flexible container 9 secured and closed by cooperation of a pivoted backing plate 1 with an abutment 8, and kneaded by reciprocating members 3, 4 which are operated out of phase (and are in the mid-position as depicted). The backing plate has a rubber cover 7. The members 3, 4 may be replaced by rollers or wheels.
[GB1402538A]