baber/WOPTO huggingface dataset:
Patent CR-20200488-A (CR)
Title: Peptide macrocycles against acinetobacter baumannii
Inventor: Hu taishan
IPC: C07K5/093
Filed: 2019-04-23
Abstract: <p>The present invention provides compounds of formula (I) wherein X<sup>1</sup>, X<sup>2</sup>, R<sup>1 </sup>to R<sup>6</sup> and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.</p>
Patent CR-20200609-A (CR)
Title: Compositions and methods for decreasing tau expression
Inventor: Polydoro Ofengeim Manuela
IPC: C12N15/113
Filed: 2016-12-19
Abstract: <p>Provided herein are compositions and methods for decreasing tau mRNA and protein expression. These compositions and methods are useful in treating tau-related diseases and disorders.</p>
Patent CR-20210287-A (CR)
Title: Inhibitors of cyclin-dependent kinase 7 (cdk7)
Inventor: CIBLAT STEPHANE
IPC: C07F9/02
Filed: 2019-11-01
Abstract: The present invention provides various compositions, including compounds of Formula (I) or (la), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.
Patent CR-20210508-A (CR)
Title: Compounds, compositions, and methods for the treatment of disease
Inventor: MASTROLIA RON
IPC: C07D487/04
Filed: 2020-03-05
Abstract: Disclosed are compounds and compositions for inhibiting the expression of a pattern recognition receptor (e.g., STING), and methods of use thereof.
Patent EC-SP055641-A (EC)
Title: Efecto antimicrobiano del quitosán en las bebidas
Inventor: SOEDJAK HELENA SETYARINI
IPC: A23L/
Filed: 2005-03-02
Abstract: La presente invención se dirige a composiciones y métodos los cuales utilizan un primer compuesto antimicrobiano (Ej.: quitosán, ácido tánico yo mezclas de ellos) en combinación con un segundo compuesto antimicrobiano (preferiblemente benzoato, sorbato, EDTA o mezclas de ellos) para inhibir el crecimiento de los microorganismos en los productos alimenticios y especialmente en las bebidas. La presente invención también está dirigida a composiciones de relleno frío y métodos de relleno frío usando solamente quitosán o en combinación con el segundo compuesto antimicrobiano (preferiblemente benzoato, sorbato, EDTA o mezclas de ellos) para matar microorganismos y/o inhibir el crecimiento de los microorganismos en las bebidas.
Patent EC-SP077159-A (EC)
Title: Derivados de 2-pirrolidona sustituida como fungicidas e insecticidas
Inventor: WACHENDORFF-NEUMANN ULRIKE
IPC: C07D493/04
Filed: 2007-01-11
Abstract: El uso de un compuesto de fórmula (I) o una sal del mismo, 	(I)en la que los símbolos tienen los significados dados en la descripción,para el control de microorganismos fitopatógenos de animales dañinos.
Patent EC-SP961683-A (EC)
Title: Esteres y amidas de 1,4 piperidina di-sustituida
Inventor: CEREDA ENZO
IPC: A61K31/24
Filed: 1996-03-07
Abstract: La presente invención describe nuevos ésteres y amidas farmacológicamente activos de 1,4-piperidina disustituida como antagonista 5-HT4 de fórmula general I (gráfico), en la cual A, X, Y y R tienen los significados especificados en la descripción, procedimientos para su preparación y composiciones farmacéuticas que los contienen.
Patent EC-SP961961-A (EC)
Title: Aparato de juego y metodo con tecla de proximidad
Inventor: BREEDING JOHN G
IPC: A63F7/22
Filed: 1996-12-04
Abstract: El presente invento es para un aparato para detectar la presencia de fichas de juego. Este aparato comprende una estructura de juego que tiene por lo menos una ubicación predeterminada para recibir una ficha de juego. En un casino, la estructura de juego puede ser una mesa de juego. En cada ubicación predeterminada para recibir una ficha de juego designada sobre la mesa de juego, esta montado un censor de proximidad para la mesa de juego tal que cada censor esta alineado con una ubicación predeterminada. Un descodificador alineado con una ubicación predeterminada. Un descodificador está eléctricamente conectado a cada censor de proximidad para determinar si una ficha de juego esta presente en cada ubicación predeterminada. Un descodificador está eléctricamente conectado a cada censor de proximidad para determinar si una ficha de juego esta presente en cada ubicación predeterminada. Cuando la presencia de una ficha de juego es captada por el descodificador, se registra la apuesta del jugador.
Patent FI-20000250-A (FI)
Inventor: BELLEY MICHEL L KAUKO JUHANI
IPC: C07D215/14
Filed: 2000-02-07
Abstract: Compounds having the formula I: <CHEM> are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
Patent FI-20020146-A (FI)
Inventor: JAANU KEIJO
IPC: F24B1/193
Filed: 2002-01-25
Abstract: The invention relates to a fireplace comprising a firebox (1) and a grate (3) provided with apertures (10) for supplying primary air into the firebox (1) comprising a wall assembly (2) provided with at least two horizontally extending arrays of apertures (100, 200, 300) for supplying secondary air into the firebox. In order to be able to burn firewood in the fireplace so that the emissions, in particular carbon monoxide and nitric oxide emissions, simultaneously remain very low, the distance between said at least two arrays of apertures (100, 200, 300) in the vertical direction ranges between 30 and 150 mm, and both arrays of apertures comprise apertures (100a, 100b, 100c and 200a, 200b, 200c) arranged to supply secondary air in a point-like manner substantially in the horizontal direction converging at an angle gamma  = 30 to 80 degrees against one another so that the point-like jets from the apertures hit one another. <IMAGE>
Patent FR-1603221-A (FR)
Title: Thermostatically controlled plastics weld-ing wheel
IPC: B29C65/00
Filed: 1968-10-16
Granted: 1971-03-22
Abstract: Welding apparatus has a wheel which is interchangeable and may have a variable size and profile. It is mounted on a metal block heated electrically and thermostatically controlled, a second articulated metal element enabling the pressure on the wheel to be varied. The apparatus maintains a constant temp. pref. for making continuous welds with polyethylene and polypropylene.
Patent GB-1022016-A (GB)
Abstract: 1,022,016. Measuring displacement electrically. LEEDS & NORTHRUP CO. March 10, 1964 [March 29, 1963], No. 10105/64. Heading G1N. [Also in Division H3] The axial position of a permanent magnet 14 (Fig. 1) in a closed magnetic core 11 of square loop material, varies the standing flux level in the core and thus varies the time taken by an A.C. voltage applied across a winding 12 to saturate the core during each cycle, that part of the voltage cycle still existing after the core has been saturated appearing across the load 18, and its mean D.C. level being a measure of the displacement of the magnet. A fixed D.C. voltage on a reset winding 13 saturates the core at a negative flux saturation level - Ï S  (Fig. 4, not shown) and the square wave voltage applied, of amplitude E, causes the flux in the core to increase continuously until either the voltage E drops again (LHS of Fig. 4) or the core saturates at + Ï<SP>1</SP> S  (RHS Fig. 4) in which case a current I<SP>1</SP> L  appears in the load. The saturation flux levels + Ï<SP>1</SP> S  and Ï<SP>1</SP> S  move together as the magnet 14 is inserted further into the core. In a push-pull arrangement (Figs. 6, 7, 8 not shown) there are two cores, each having only an A.C. winding, and each driving into opposite ends of the load, the D.C. winding being dispensed with by arranging that part of the saturation current flowing during one half-cycle in the winding of the saturated core flows via a resistor (27) through the winding of the second core in reverse direction to reset that core preparatory to its saturation during the next half cycle. Transistors are used (Fig. 8 not shown) to reduce the pushpull switching losses. Various full wave arrangements are described, the first having two cores (Fig. 9 not show), the second having one core and a full wave bridge rectifier, and the third being a push-pull refinement using four cores. Rotation of the permanent magnet 14 may be detected by including further magnetic pole pieces 38, 38<SP>1</SP> (Fig. 11 hot shown), or equivalent windings 25, 25<SP>1</SP> (Fig. 5 not shown), the flux in the toroid being varied by the variation in the resultant of the rotatable and fixed fields. The permanent magnet may be fitted with magnetic flanges to reduce fringe effects.
Patent GB-1054361-A (GB)
IPC: G01N3/00
Abstract: 1,054,361. Investigating welds. IMPERIAL CHEMICAL INDUSTRIES Ltd. March 13, 1964, No. 10417/63. Heading H5R. A radiograph is prepared, as a standard against which radiographs of welds can be compared to assess permissible imperfections, by assembling between two sheets of material and within boundary limits equal to the width of the weld to be assessed, various elements representing, in size and location, the permissible imperfections, and then taking a radiograph of the assembly. The assembly is constructed with sheets 1, 2. 3 (Fig. 1, not shown), of the same metal as the parent metal of the weld to be assessed are of the same total thickness. Runs of weld metal 5 of the same size and composition as the weld to be assessed are deposited on the outside surfaces. The inner surfaces of the sheets are coated with grease in which are located the elements representing the imperfections, e.g. ball-bearings to produce indentations in the sheets representing gas pores and pieces of slag or tungsten. The sheets are pressed together to form the indentations, separated to remove the ball-bearings and re-assembled together for the taking of the radiograph, locating pins &c. being used to readily effect this. A more accurate standard is obtained using a plurality of thin sheets rather than two or three thicker ones. Inclusions may also be represented by etching.
Patent GB-1225655-A (GB)
IPC: C08G59/50
Filed: 1968-06-17
Abstract: 1,225,655. Epoxy resin coating. DEXTER CORP. 17 June, 1968 [12 July, 1967], No. 28657/68. Heading B2E. [Also in Divisions C2 and. C3] Steel bars are coated with epoxy resins by preheating the steel bar (e.g. at 210C. for 15 minutes) then dipping in a fluidized bed of epoxy resin powder, containing as catalyst a novel water-insoluble complex of a tertiary amine and tetrachlorophthalic or tetrabromophthalic acid, then curing in a oven.
Patent GB-1226884-A (GB)
IPC: B24D11/00
Filed: 1968-04-18
Abstract: 1,226,884. Flexible abrasive articles. NORTON CO. 18 April, 1968 [24 April, 1867], No. 18445/68. Heading C4V. An abrasive product comprises a flexible backing, a resilient, porous foamed material of density 10 to 30 pounds per cubic foot, a 25% compression deflection value of 10 to 50 pounds per square inch and a porosity of 55 to 85%, secured thereto by adhesive and abrasive grain distributed on and within the porous material, the abrasive density being a minimum at the interface between the foam and the backing and a maximum at the opposite face. The foam, which is preferably of polyurethane, may be a reconstituted particulate material and the backing may be adhered with a rubber- or neoprenebased adhesive or a self-crosslinking acrylic resin. The abrasive may be silicon carbide, aluminium oxide, garnet, flint, diamond or emery. The grit may be adhered with a drying- oil-modified phenolic or epoxy resin.
Patent GB-1228029-A (GB)
IPC: F25B9/12
Filed: 1968-04-19
Abstract: 1,228,029. Refrigerating. PHILIPS GLOEILAMPENFABRIEKEN N.V. 19 April. 1968 [22 April, 1967], No. 18674/68. Heading F4H. A load is continuously cooled by forcing helium II through a superleak to provide superfluid helium at the load. The heat generated by the load causes part of the superfluid to be converted to normal helium II and the resultant mixture of superfluid and normal helium is moved with a velocity exceeding its critical velocity either into, or into heat exchange with, a helium II bath to reject heat prior to further passage through the superleak. As illustrated, a dewar 8 contains a liquid helium bath which is maintained below the lambda point by evacuation. The bath surrounds an enclosure 6 which is evacuated through a connection 7. A closed liquid helium circuit is provided which comprises a pump 2, the superleak 3, a chamber 4 containing the load 11, and a duct 5 in which the helium exceeds its critical velocity. The bath may be at 1À3‹ K., the load may be at 0À7‹ K., and the superleak may be formed of carborundum or iron oxide. Since the duct portions are in heat exchange relationship with the bath, pressurized helium is presented to the superleak at the temperature of the bath, and the helium leaving the vacuum jacketed region at 12 rejects heat to the bath. In a modification, Fig. 2 (not shown), the helium circuit is not closed, and helium leaving the vacuum jacketed region is passed into the bath. The pump withdraws helium from the bath for passage to the superleak.
Patent GB-1230089-A (GB)
IPC: F16H37/00
Filed: 1967-09-19
Abstract: 1,230,089. Reverse gear. HUNSLET (HOLDINGS) Ltd. 23 Aug., 1968 [19 Sept., 1967], No. 42509/67. Heading F2D. In a reversing gear-box for a locomotive or other vehicle, two bevel gears 18, 19 respectively mounted on the inner ends of two, separate, coaxial input shafts 12, 13 mesh forward and reverse bevel gears (one, 20, shown) connectable to an output axle 22 through reversing clutch means (not shown) and gearing 21. The input shafts 12, 13 are connected to respective power units 16, 17 via input balancing or relating means such as the torque converters 24, 25 and flywheels 26, 27 shown.
Patent GB-1230634-A (GB)
IPC: B22C13/12
Filed: 1968-05-25
Abstract: 1,230,634. Core-making machines; core boxes. METALS & EQUIPMENT (WOLVERHAMPTON) Ltd. 13 May, 1969 [25 May, 1968], No. 25105/68. Heading B3F. A core-making machine has a multicavitied heated core-box having a centre part 13 and two co-operating outer parts 14, 15. A heat curable moulding material is blown into the core-box from a head 99. At each side of the sand blowing station is a core-box preparation and core extraction station to which the centre part of the core-box 13 is movable. Two core-box centre parts are employed so that while one is being prepared the other is under the sandblowing head. The core-box centre part 13 (Fig. 2) has Y- shaped core cavities 40 each with two mandrels 80. Slotted permanent magnets 43 are provided to hold metal spacers 30 (Fig. 8) for the cores. The spacers are loaded on the polepieces 27 of electromagnets on swinging doors 26 (Fig. 1) of the machine. The doors 26 are swung parallel with the cavity-containing sides of core-box parts 13 at the preparation station and the polepieces with the spacers 30 moved towards the part 13 to transfer the spacers to the permanent magnets. The electromagnets are deenergized and withdrawn, the mandrels 80 inserted into the cavities and the centre part moved beneath the blower head for core moulding.
Patent GB-1232685-A (GB)
IPC: B61G5/10
Filed: 1968-06-04
Abstract: 1,232,685. Line couplings for automatic railway couplers. MINISTERIUM FUR VERKEHRSWESEN. 4 June, 1968, No. 26456/68. Addition to 1,215,211. Heading B7T. On the front face 8 of the line coupling described in the parent Specification there is formed a vertical fender 14 of trapezoidal prism form which has inner and outer run-up surfaces 15 adapted to be contacted by the small claw of a counter coupler during coupling such that the line coupling is first moved backwardly into the duct in which it is located before being brought forward for coupling, the fender being arranged to lie beside the housing of the counter-line coupling when coupled therewith.
Patent GB-1232763-A (GB)
IPC: A61F5/445
Filed: 1970-02-13
Abstract: 1,232,763. Urine collecting bag. CUXSON, GERRARD & CO. Ltd. 13 Feb., 1970, No. 6930/70. Heading A5R. A urine collecting bag made from a flexible material has an inlet opening 6, an outlet duct 4, and contains a valve member which can be inserted into the opening of the outlet duct from within the bag by manipulation from outside the flexible walls of the bag so that the duct may thus be closed without contacting the urine.  As shown, the bag comprises of two similar sections 1 of transparent or translucent material which are thermally welded together around their periphery 2. The inlet opening is provided with a collar 7 which may be attached directly or indirectly to the skin. The valve member takes the form of a tapered plug of wood or plastics material.
Patent GB-1233524-A (GB)
IPC: B24B3/24
Filed: 1969-01-25
Abstract: 1,233,524. Grinding drills. Z. BRIERLEY Ltd. 25 Jan., 1969, No. 4338/69. Heading B3D. A drill point grinding machine comprises a motor-driven grinding wheel 11 and a workhead including a main housing 16 pivotally arranged upon a support 15 and carrying a chuck 17 for a drill to be ground, the housing embodying a mechanism for simultaneously rotating and axially reciprocating the chuck and for swivelling the housing by means of a crank 21 coupled by a connecting rod 23 to a swivel bar 25 pivotally connected to the support 15, and releasable locking means for locking the swivel arm to prevent it from swivelling. The support 15 can be adjusted about a pivot 14 along an arcuate track 13 and locked in position according to the taper angle of the tip of the drill. The housing 16 is also mounted on the pivot 14 and includes a mechanism 19 which, when operated by a handle 18, rotates and axially reciprocates the chuck 17. A gear 20 in the mechanism 19 is connected by the crank 21 and a spherical bearing 22 to one end of the connecting rod 23, the other end of which is connected by a spherical bearing 24 to the swivel bar 25. The latter is mounted by a releasable locking nut 27 on a bracket 26 secured to the support 15. A register pin 29 is slidable in the bracket between one position in which it engages a hole 32 in the housing 16 and a second position in which it engages a hole 31 in the bar 25 to prevent swivelling thereof. When the pin 29 is engaged with the hole 31, operation of the mechanism 19 causes simultaneous rotation and axial reciprocation of the chuck and swivelling of the housing 16 for effecting normal grinding of the drill tip. With the pin engaged in hole 32, the housing 16 is locked to the support and the arm 25 is free to swivel so that operation of the mechanism 19 only causes rotation and axial reciprocation of the chuck so that cutting shoulders may be ground on pilot or step drills.
Patent GB-1251415-A (GB)
IPC: F16B43/00
Filed: 1969-02-07
Abstract: 1,251,415. Magnetic tape containers. RCA CORPORATION. 7 Feb., 1969 [16 Feb., 1968], No. 6684/69. Heading G5R. A magnetic tape container includes an exit 38 provided with air jets 62, 64 directed at opposite sides of the tape and towards the interior to prevent more than one strand of tape leaving the container. The device is provided in a bin as described in Specification 1,234,174 and consists of two chambers 46, 48 supplied with air under pressure and also providing an air-bearing via ports 58, 60.
Patent GB-1257021-A (GB)
IPC: F02M69/04
Filed: 1968-01-02
Abstract: 1,257,021. I.C. engine fuel injectors. JOSEPH LUCAS (INDUSTRIES) Ltd. Jan. 21, 1969 [Jan. 2, 1968], No.225/68. Heading F1B. An injection nozzle 11 suitable for mounting in an I.C. engine intake manifold (10), Fig. 1 (not shown), comprises a ball or poppet valve 14 to be opened by fuel pressure pulses and a part 15 enclosing the discharge end of the valve and defining therewith a chamber 16. The part 15 has an air inlet opening or openings 21 through which atmospheric pressure air or air from an enginedriven positive displacement pump flows to the chamber 16. Mixture flows from the chamber through one or more restricted outlet holes 17 and a tubular extension 18 of the part 15. The part 15 is screw-threaded at 22 for insertion into an insulating bush in the manifold or directly into the manifold.
Patent GB-1258106-A (GB)
IPC: G05D23/24
Filed: 1969-04-10
Abstract: 1,258,106. Automatic temperature control systems. MATSUSHITA ELECTRIC INDUSTRIAL CO. Ltd. April 10, 1969, No. 18454/69. Heading G3R. A firing circuit for a controlled rectifier e. g. a thyristor 8 serially connected with an electric blanket heater 4, 4<SP>1</SP> comprises detector wires 16, 16<SP>1</SP> separated by a temperature dependent layer 32, which below a temperature determined by series resistor 14 causes a neon lamp 18 to discharge once per half cycle. The current pulses are transmitted through a pulse transformer 20, 21 to the thyristor gate with an angular delay depending on temperature. The neon may be replaced by a bi-directional switch (19) Fig. 10 (not shown). A capacitor 21 and choke 5 reduce electrical interference, and a resistor 6 and capacitor 7 prevent spurious firing. A diode 2 increases current flow should thyristor 18 become internally short circuited thus blowing a fuse 8, and a layer 29 of say nylon 6 or 610 between heater parts 4, 4<SP>1</SP> fuses above a determined temperature say 150-200‹ C. causing a shunt between the two parts hence also blowing the fuse. The heater and detector coils may be spaced more closely near the foot of the blanket than the head, see Fig. 7 (not shown).
Patent GB-1259054-A (GB)
IPC: C07D327/04
Filed: 1970-04-21
Abstract: 1,259,054. Benzoxathiolium salts. CHEMIEKOMBINAT BITTERFELD VEB. 21 April, 1970, No. 19028/70. Heading C2C.  Novel benzo-1,3-oxathiolium salts of the formula in which R 1  is hydrogen, -NR<SP>1</SP>R<SP>11</SP>, -OR<SP>1</SP> or -SR<SP>1</SP> or an alkyl, optionally substituted aryl or a heterocyclic radical, R 2 , R 3  and R 4  are hydrogen, halogen, hydroxy, -OR<SP>1</SP>, -SR<SP>1</SP> or -NR<SP>1</SP>R<SP>11</SP> or alkyl or aryl radicals or R 2  and R 3  together form a fused ring (where R<SP>1</SP> and R<SP>11</SP> are hydrogen, alkyl, optionally substituted aryl or together complete a heterocyclic ring) and A is the anion of a strong mineral acid, are prepared by heating to boiling in acetic acid and a strong mineral acid, a thiocarbonyl compound of the formula in which X is hydroxy, mercapto or -NR<SP>1</SP>R<SP>11</SP> and an equimolar amount of a quinone of the formula where R 5  is hydrogen, halogen or -SR<SP>1</SP>, cooling the reaction mixture to 30-60‹ C., adding an amount of acetic anhydride equal in volume to the acetic acid used, reheating to about 120‹ C. and, after cooling, precipitating the salt by addition of a a slightly polar solvent. If the thiocarbonyl compound is one in which X is hydroxy or mercapto, the addition of acetic anhydride may be omitted. Examples relate to the preparation of perchlorates in which R 1  is a phenyl, p-dimethylaminophenyl, p-methoxyphenyl or dimethylamino group.
Patent GB-1264382-A (GB)
IPC: C08L21/00
Filed: 1969-01-21
Abstract: 1,264,382. Hexamethylenetetramine salts with toluene sulphonic acids. GOODYEAR TIRE & RUBBER CO. 21 Jan., 1969 [29 Jan., 1968], No. 45880/71. Divided out of 1,264,381. Heading C2C. The invention comprises the product of a mixture of o-, m- and p-toluenesulphonic acids with hexamethylenetetramine. The reaction may be carried out by reacting a solution of a mixture of o-, m- and p-toluenesulphonic acids in 2-propanol with a solution of hexamethylenetetramine in 2-propanol and filtering off the precipitate formed.