baber/WOPTO huggingface dataset:
Patent NZ-529785-A (NZ)
Title: Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter protein ABC1
Inventor: LAWN RICHARD M
IPC: A61P9/00
Filed: 2000-06-16
Abstract: Disclosed are ABC1 polypeptides and nucleic acid molecules encoding the same. The disclosure also relates to recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as to methods for producing ABC1 polypeptides. The disclosure also relates to antibodies that bind specifically to ABC1 polypeptides. In addition, the disclosure relates to methods for increasing cholesterol efflux as well as to methods for increasing ABC1 expression and activity. The disclosure further relates to methods for identifying compounds that modulate the expression of ABC1 and methods for detecting the comparative level of ABC1 polypeptides and polynucleotides in a mammalian subject. The disclosure also provides kits and compositions suitable for screening compounds to determine the ABC1 expression modulating activity of the compound, as well as kits and compositions suitable to determine whether a compound modulates ABC1-dependent cholesterol efflux. In particular, medicaments for increasing cholesterol efflux from cells in a mammalian subject are disclosed. Such medicaments include a ligand for a nuclear receptor, such as LXR, RXR,FXR and SXR ligands. Such treatments are suitable for increasing circulating HDL levels, desirable in conditions such as Tangier Disease, and in patients with low HDL levels. (62) Divided out of 516061
Patent NZ-529859-A (NZ)
Title: Sustained release pharmaceutical composition
Inventor: MARTINOD SERGE R
IPC: A61K9/00
Filed: 2002-07-01
Abstract: A sustained release apparatus including a plurality of sustained release mini-implants or pellets; each mini-implant including: a sustained release support material; and a pharmaceutically active composition carried in or on the sustained release support material; the pharmaceutically active composition including: at least one pharmaceutically active component; and a carrier therefore; each implant being of insufficient size and/or payload individually to provide a predetermined desired threshold blood level of pharmaceutical active for treatment of a selected indication; the size(s) of the mini-implants or pellets providing zero order release of pharmaceutical active; the sustained release apparatus providing, in use, zero order release of pharmaceutically active at, or above, the desired threshold level of pharmaceutical active treatment of a selected indication, is disclosed. A sustained release kit is also disclosed. The described sustained release mini-implants or pellets are useful in the manufacture of a sustained release delivery apparatus for the therapeutic or prophylactic treatment of a disease condition in an animal. A method for the therapeutic or prophylactic treatment of a disease condition in an animal (not including a human) requiring such treatment, which method includes administering to the animal a sustained release delivery apparatus as described above is also disclosed.
Patent NZ-534236-A (NZ)
Title: Method and apparatus for clinical trials
Inventor: MOMICH ROBERT
IPC: G06F19/00
Filed: 2002-12-23
Abstract: A method for conducting clinical trials for a medication using a unique identifier, a clock and a smart memory associated with the medication is disclosed. Information regarding a method of calculating a next take time is received. It is determined if an identifier field on the smart memory is empty and, if empty, proceeding with a setup routine. If not empty, it is determined if the identifier in the identifier field is not the unique identifier and if not then exiting. If the unique identifier is present in the identifier field then; calculating the next take time; storing a next take time; and prompting at the next take time. The time on the clock is stored as a take time. In addition, a subject diary form is displayed and subject information in regard to subject diary form is stored.
Patent NZ-534960-A (NZ)
Title: Handle assembly for tool
Inventor: DINEEN CHRISTOPHER
Filed: 2004-08-27
Abstract: A power sander having a housing and a motor within the housing. A gripping portion adapted to be engaged by a hand of a user comprises blister packs with first and second flexible sheets defining a gel containing chamber there between and a vibration damping gel material, the first and second sheets being sealed to each other at the periphery of each gel containing chamber. Clamping plates include a body portion and pins adapted to extend through the periphery of a corresponding blister pack and to protrude inwardly of the surface of the housing. The pins are then deformed by means of heat or ultrasound to secure the clamping plates to the housing.
Patent NZ-537561-A (NZ)
Title: Method for inducing a conformational transition in proteins such as pathogenic/infectious proteins
Inventor: ZAHN RALPH
IPC: C07K14/47
Filed: 2003-07-03
Abstract: Disclosed is an in vitro method for increasing the content of beta-sheet secondary structure in recombinant amyloidogenic proteins, comprising: a) mixing a conversion buffer, a solution of lamellar lipid structures that comprise negatively charged lipids and recombinant amyloidogenic proteins; b) exposing the mixture of step a) to a converstion temperature for a time sufficient to increase the beta-sheet secondary structure in the recombinant amyloidogenic proteins, wherein water soluble complexes of lamellar lipid structures and amyloidogenic oligomeric beta-sheet intermediate structures are formed. Also disclosed are amyloidogenic oligomeric beta-sheet intermediate structures produced by the above method.
Patent NZ-538625-A (NZ)
Title: 1,3-Diamino-2-hydroxypropane prodrug derivatives
Inventor: FOBIAN YVETTE M
IPC: A61P25/16
Filed: 2003-09-08
Abstract: Disclosed is a compound of formula I wherein: one of RN and RN' is H and the other is -C(=O)-(CRR')0-6R100, -C(=O)-(CRR')1-6-O-R100, -C(=O)-(CRR')1-6-S-R100, -C(=O)-(CRR')1-6-C(=O)-R100, -C(=O)-(CRR')1-6-SO2-R100, -C(=O)-(CRR')1-6-NR100-R'100, or Y=Z-X-(CH2)n7-C(R4)HC(O)-; R1 is -(CH2)1-2-S(O)0-2-(C1-C6 alkyl) or substituted C1-10- alkyl, optionally substituted alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkylaryl, alkylheteroaryl or heterocyclyl; R2 and R3is selected from the group consisting of H, alkyl, alkylaryl; alkylheteroaryl, alkenyl, alkynyl, -CONRN-2-RN-3, -SO2NRN-2-RN-3, -CO2H; and -CO2-alkyl; or R2 and R3 and the carbon to which they are attached form a carbocycle of 3-7 carbon atoms wherein one carbon atom is optionally replaced by a group selected from -O-, -S-, -SO2-, or -NRN-2-; and the remaining substituents are as defined in the specification. Compounds of the type disclosed are prodrugs of compounds that inhibit beta secretase and are particularly useful in the treatment of Alzheimers' disease.
Patent NZ-538878-A (NZ)
Title: Inflating watercraft flotation device
Inventor: MEARS TONY W
IPC: F17C7/00
Filed: 2003-08-18
Abstract: A flotation device for floating a watercraft is provided. The flotation device comprises a cover releasably secured to the watercraft. A first collapsible tubing is positioned between the cover and the watercraft for removing at least a portion of the cover. At least one inflatable flotation bladder is positioned between the cover and the watercraft wherein upon inflation of the first collapsible tubing the first collapsible tubing releases at least a portion of the cover from the watercraft.
Patent NZ-540981-A (NZ)
Title: Cutting tool
Inventor: PARK KEITH
IPC: A01G3/06
Filed: 2005-06-27
Abstract: A cutting tool is provided for performing a cutting operation. The tool includes a cutting blade provided for movement to perform the cutting operation and a guard which covers at least part of the cutting blade. The tool further includes cleaning means, the cleaning means including a cleaning part positionable within the guard and controllable to allow relative movement between the guard and the cleaning part.
Patent NZ-546350-A (NZ)
Title: Lavatory with a removable washing platform
Inventor: PIATT JAMES M
IPC: A47K1/04
Filed: 2004-08-25
Abstract: A spout (18) directs a stream of water (22) onto an adjacent washing apparatus. The washing apparatus has a body with a first work surface (135) and a drain opening (138) that is connected by a coupling to the waste water system of a building. A second platform is removably positionable on the first work surface and has a second work surface raised from the first work surface.
Patent NZ-547305-A (NZ)
Title: Rumen bacteria variants and process for preparing succinic acid employing the same
Inventor: LEE SANG YUP
IPC: C12N1/21
Filed: 2004-05-20
Abstract: Provided is a rumen bacterial mutant which a lactate dehydrogenase-encoding gene (ldhA) and a pyruvate formate-lyase encoding gene (pfl) have been disrupted, and has the property of producing succinic acid at high concentration while producing little or no other organic acids in anaerobic conditions. Further provided are similar mutants with various combinations of the disrupted genes ldhA, pfl, pta and ackA.. Also provided are methods for producing such mutants and methods of producing succinic acid with such mutants.
Patent NZ-547612-A (NZ)
Title: Gag binding proteins
Inventor: KUNGL ANDREAS J
IPC: C07K14/54
Filed: 2004-12-02
Abstract: Disclosed is a method for the production of an antagonist of a GAG binding wild type protein wherein the GAG binding region in said GAG binding protein is modified by substitution, insertion, and/or deletion of at least one amino acid in order to increase the relative amount of basic amino acids in said GAG binding region, and/or reduce the amount of bulky and/or acidic amino acids in said GAG binding region, so that the GAG binding affinity of said modified GAG binding protein is increased compared to the GAG binding affinity of said GAG binding wild-type protein. Further disclosed are modified GAG binding proteins produced according to this method, and pharmaceuticals comprising such for the treatment of inflammatory conditions including arthritis, psoriasis, asthma, Alzheimer's disease and multiple sclerosis.
Patent NZ-550519-A (NZ)
Title: Holding device for accommodating a mobile terminal/screen
Inventor: WOBBEN ALOYS
IPC: B60R11/02
Filed: 2005-04-15
Abstract: A portable removable holding device for accommodating a mobile unit, in particular a data processing apparatus, and/or a screen in the passenger region of a vehicle is disclosed. The device includes at least one holder having a first portion for removable insertion in/on a dashboard of a vehicle and a second portion for accommodating the mobile unit and/or the screen. At least one nose and/or hook is provided on the first portion for fixing the holding device in the passenger side region of the console of a vehicle, such that fixing the holding device at the console and removing it in a quick and easy way is facilitated.
Patent NZ-551308-A (NZ)
Title: Prolongation of survival of an allograft by inhibiting complement activity
Inventor: ROTHER RUSSELL P
IPC: A61K45/06
Filed: 2005-05-16
Abstract: Disclosed is the use of an antibody to C5 which inhibits complement activity for the manufacture of a medicament to be administered with at least one immunosuppressive drug to prolong survival of an allograft in a recipient mammal, wherein said antibody to C5 is to be administered chronically.
Patent NZ-551394-A (NZ)
Title: Air conditioning apparatus with condensate drawn through negative pressure aperture of drain pan structure
Inventor: DAVENPORT BRADFORD B
Filed: 2006-11-20
Abstract: Air conditioning apparatus is disclosed where a negative pressure is created so as to draw condensate through an opening in a wall of a drain pan divided by the wall into a condensate catching portion and a drain portion.
Patent NZ-552247-A (NZ)
Title: Method for producing an iron sulfate-based phosphate adsorbent
Inventor: MULLER HANS-MARTIN
IPC: A61K33/26
Filed: 2005-06-21
Abstract: Disclosed is a process for the preparation of a composition, comprising the following steps utilising suitably low chloride containing: a) adding at least one base to an aqueous iron (III) sulphate and/or iron(III) nitrate to form a precipitate of iron hydroxide, b) optionally washing the resulting precipitate one or more times with water, yielding an aqueous suspension of the iron hydroxide, c) adding to the resulting aqueous suspension at least one further constituent that inhibits ageing of the precipitate of iron hydroxide obtained in step b), d) drying the composition obtained in step c) to yield a composition containing less that 0.05 wt.% chloride. Also disclosed is the use of the composition obtained according to the above process in the production of a preparation for the prophylaxis and/or treatment of the hyperphosphataemic state.
Patent NZ-552478-A (NZ)
Title: Process for producing nut products, beverages, liqueurs, desserts and food products therefrom
Inventor: SANTO PAOLINA
Filed: 2005-06-23
Abstract: The disclosure relates to a process for producing nut products. The disclosure also relates to beverages, liqueurs, desserts and food products therefrom such as a dough-like nut product and nut milks, marzipans, nut spreads, liqueurs and ice creams and granitas made from these processes. Particularly disclosed is a process for producing a nut product comprising nuts, a source of sugar, and flavouring agents, wherein the process comprises the steps of: (a) mixing said nuts together with a portion of said source of sugar to form a blend; (b) grinding in a plurality of passes said blend so as to form a paste; and (c) mixing said paste with the remaining portion of said source of sugar so as to form a nut product.
Patent NZ-555466-A (NZ)
Title: 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators
Inventor: MIYAJI KATSUAKI
IPC: A61K31/415
Filed: 2005-12-07
Abstract: Disclosed are 3-ethylidenehydrazino substituted heterocyclic compounds represented by the formula (1), tautomers and pharmaceutically acceptable salts thereof, wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description. These compounds have an agonistic action on the thrombopoietin receptor and are suitable for making pharmaceutical compositions comprising compounds for increasing platelets through stimulation of differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti- arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.
Patent NZ-567199-A (NZ)
Title: Horse bit
Inventor: STEVENSON LOWELL DEAN
IPC: B68B1/06
Filed: 2006-09-15
Abstract: A horse bit (1) has a mouth bar (2) and two control bars (3). The mouth bar (2) is arched and is in the range of 5 mm to 10 mm in diameter and its length is dependent on the size of the horse. The control bars (3) are formed integrally with, and from the same material as, the mouth bar (2) and are located at opposed ends of the control bar (2). The mouth bar (2) and the control bars (3) are substantially coplanar. Each control bar (3) is angled inwardly to engage a region of the horse's jaw and makes an angle that is in the range of 75 DEG to 90 DEG with the adjacent portion of the mouth bar (2).
Patent NZ-568992-A (NZ)
Title: Platelet aggregation assays comprising platelet activiating agents and agents that cross-links the CD40L-binding moiety
Inventor: HSU YEN-MING
IPC: G01N33/86
Filed: 2006-11-17
Abstract: Disclosed is an in vitro method of assaying platelet aggregation comprising: contacting platelets with a platelet activating agent; contacting the activated platelets with a CD40L-binding moiety; and contacting the activated platelets with an agent that cross-links the CD40L-binding moiety, wherein the CD40L-binding moiety and the agent that cross-links the CD40Lbinding moiety are not a preformed immune complex, and wherein sedimented platelets are indicative of aggregation of the platelets.
Patent NZ-571242-A (NZ)
Title: Storage container and container system
Inventor: FURLONG BRIAN
IPC: B65D43/02
Filed: 2007-02-09
Abstract: A storage container system is disclosed. The system includes: a number of container bases (30) each having a bottom (36), a continuous side wall (34) extending up from the bottom and terminating at a top edge (40), an interior storage space within the side wall above the bottom, and an open top (42) bounded by the top edge; a number of lids (50) each having a main panel section (48), a perimeter skirt assembly (50) around the main panel section, a top side (44), and a bottom side (46), each of the lids configured to close off the open top of any one of the container bases by connecting a part of the perimeter skirt assembly to the side wall near the open top; a first snap structure on each of the lids, each first snap structure having one component configured to connect to a mating lid component of the first snap structure on any other one of the lids to connect any two of the lids together; and a second snap structure different from the first snap structure on each of the lids, the second snap structure having a component configured to connect to a mating base component on the base to connect anyone of the lids to any one of the container bases.
Patent NZ-573286-A (NZ)
Title: (1-Benzyl-3-{ [2-(1-cyclopentyl-piperidin-4-ylamino)-benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester and analogues thereof
Inventor: DE KOCK HERMAN
IPC: C07D277/82
Filed: 2007-06-22
Abstract: Disclosed are (1-benzyl-3-{ [benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl esters of the general formula (I), wherein R is a piperidine or a pyrrolidine ring which is optionally substituted on one or more of the ring members. Of particular importance is the compound (1-benzyl-3-{ [2-(1-cyclopentyl-piperidin-4-ylamino)-benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester. Further disclosed is a pharmaceutical composition comprising an effective amount of at least one compound as defined above, and a pharmaceutically tolerable excipient for treating or combating infection or disease associated with multi-drug resistant retrovirus infection in a mammal.
Patent NZ-575346-A (NZ)
Title: 5- (2-furyl)-1, 3-thiazole derivatives useful as inhibitors of phosphatidylinositol 3-kinase
Inventor: WANG TIANSHENG
IPC: A61P35/00
Filed: 2007-09-04
Abstract: Disclosed is a furan substituted thiazole of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) include: (R)-5-(2-acetamido-4-methylthiazol-5-yl)-N-(2-hydroxy-1-phenylethyl)furan-2-carboxamide and EthyI 5-(2-(cyclopropanecarboxamido)-4-methylthiazol-5-yl)furan-2-carboxylate. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating or lessening the severity of a disease or condition selected from rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, lacrimal parotid gland syndrome, chronic obstructive pulmonary disease, pancreatitis, myocardial infarction, diabetes, multiple sclerosis or cancer.
Patent NZ-575578-A (NZ)
Title: A neural response process
Inventor: LITHGROW BRIAN JOHN
IPC: A61B5/374
Filed: 2005-09-01
Abstract: A neural response system, includes electrodes for connecting to a person to obtain a neural response signal; an amplifier for receiving and producing a sampled form of said signal for processing; and an analysis module for processing said signal to generate a TAP (time action potential) marker to indicate whether a person has a disorder such as Meniere's disease, Parkinson's disease and depression. (62) Divided Out of 553530
Patent NZ-580238-A (NZ)
Title: Nitrogenous heterocyclic compounds, preparation thereof and use thereof as antibacterial medicaments
Inventor: LAMPILAS MAXIME
IPC: A61K31/529
Filed: 2008-04-11
Abstract: Disclosed herein are nitrogenated heterocyclic compounds of formula (I) e.g. Trans 8- (aminomethyl)-4,8-dihydro-1-methyl-5(sulphooxy)-4,7-methano-7H-pyrazolo[3,4-e] [1,3]diazepin-6(5H)-one,, wherein the substituents are as defined within the specification, processes for their preparation, pharmaceutical comprising said compounds and uses thereof as antibacterial drugs.
Patent NZ-581581-A (NZ)
Title: Methods and kits to detect hereditary angioedema type III using mutation in coagulation factor XII
Inventor: DEWALD GEORG
IPC: G01N33/573
Filed: 2005-05-18
Abstract: Disclosed is a method of diagnosing hereditary angioedema type III (HAE III) or a predisposition thereto comprising determining the presence or absence of a disease associated mutation. The mutation in a nucleic acid comprises a 6927 C to A or a 6927 C to G mutation of the wild-type sequence of the coagulation factor XII gene. The mutation in a coagulation factor XII polypeptide comprises a transversion of amino acid residue 309 or 310. The presence of the mutation is indicative of hereditary angioedema type III or a predisposition thereto. Also disclosed is a non-human transgenic animal comprising the mutation, oligonucleotides containing the mutation, polypeptides encoding the mutation and antibodies to the polypeptide.
Patent NZ-585313-A (NZ)
Title: Pyrimidine derivatives for the treatment of asthma, copd, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, cancer, hepatitis b, hepatitis c, hiv, hpv, bacterial infections and dermatosis
Inventor: BENNETT NICHOLAS J
IPC: A61K31/505
Filed: 2008-11-21
Abstract: Disclosed are pyrimidine derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof. An example of the compounds of formula (I) is Methyl 2-(3-((3-(2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)methyl)phenyl) acetate. The compounds of formula (I) are used to treat asthma, COPD, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, cancer, hepatitis B, hepatitis C, HIV, HPV, bacterial infections and dermatosis.
Patent NZ-586021-A (NZ)
Title: Hydroxyalkyl starch derivatives and process for their preparation
Inventor: HACKET FRANK
IPC: A61K47/48
Filed: 2008-12-15
Abstract: Disclosed herein is a method for the preparation of a hydroxyalkyl starch (HAS) derivative of formula (III), comprising reacting a hydroxyalkyl starch (HAS) of formula (I) via carbon atom C* of the reducing end of the HAS with the amino group M of a crosslinking compound according to formula (II), wherein A represents an acetal or ketal group; and L is a spacer bridging M and A, wherein C* is optionally oxidised prior to the reaction of HAS with M to obtain a HAS derivative according to formula (III), wherein the substituents are as defined within the specification. Also disclosed is the hydroxyalkyl starch derivative of formula (III) and (IV). Such compounds are useful in the stabilization of polypeptides.
Patent NZ-591833-A (NZ)
Title: Aryl sulfonamide amine compounds and their use as 5-ht6 ligands
Inventor: NIROGI RAMAKRISHNA
IPC: C07D207/04
Filed: 2009-03-03
Abstract: Disclosed is an aryl sulphonamide amine compound of formula (I) wherein the substituents are as disclosed. Examples of compounds of formula (I) are: N-[4-Chloro-3-(1-methylpiperidin-4-ylamino) phenyl] benzenesulfonamide; 4-Fluoro-N-[4-Chloro-3-(1-methylpiperidin-4-ylamino) phenyl] benzenesulfonamide and 4-Methyl-N-[4-Chloro-3-(1-methylpiperidin-4-ylamino) phenyl] benzenesulfonamide. Also disclosed is a process of preparing a compound of formula(I), a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating diseases related to the serotonin 5-HT6 receptor.