baber/WOPTO huggingface dataset:
Patent BG-107834-A (BG)
Title: Histamine receptor antagonists
Inventor: JENKINSON STEPHEN
IPC: A61P27/16
Filed: 2003-05-21
Abstract: The invention relates to a combination of histamine H1 receptor antagonist and selective H4 histamine receptor antagonist for the treatment of diseases which can be treated by antagonism to one or both H1 and H4 receptors, including allergic diseases and disorders such as allergic rhinitis and asthma. The invention also relates to the use of this combination, to compositions, products and methods for the treatment wherein the combination is used, as well as to selective histamine H4 receptor antagonist. 13 claims
Patent BG-111632-A (BG)
Title: Tremolo device for string instruments and string instruments
Inventor: MASLAROV TEODOR
IPC: G10D3/04
Filed: 2013-11-26
Abstract: The invention relates to a tremolo device for stringed instrument and stringed instrument. Tremolo device (1) comprises a base (2) with mounted independently of each other pairs of saddles (3) corresponding to the strings. Each pair of saddles (3) comprises a front (4) and rear (5) a seat located in one plane on the base (2) and articulated with asymmetrical arms and a connecting element (6). Each pair of saddles (3) has a locking screw (7) for positioning the base (2), pad (9) and locking screw (10) to lock the string (32) and screw (8) to fine tune. To the base (2) is mounted vibrato unit (16) with cutouts (16a) and the openings (16b) for the strings, and bad spring (17) resting on the corresponding rear saddle (5). To vibrato unit (16) is provided a balancing mechanism (21) and handle (19) for manipulation. So tremolo device (1) has a compact design, little details, low profile, smooth surface and provides a technological operations and quick and easy installation in making stringed instruments. String instrument is equipped with a tremolo device (1) and locking block (37), located just behind the bridge of the instrument.
Patent BG-112167-A (BG)
Title: Structure and method for surface enhanced ramon scattering
Inventor: VLAHOV EMIL
IPC: H01S3/30
Filed: 2015-12-04
Abstract: According to the method for obtaining structures with surface-enhanced Raman scattering based on niobium, the surface of the sample is irradiated with a series of femtosecond laser pulses of a certain energy density, overlapping the treated area. By changing the pulse energy density, a repetitive action of several consecutive pulses, a corresponding modification of the surface of the sample and its chemical composition, varying with the distance from the surface (convex and concave areas), is obtained. The energy density of the applied laser pulses is controlled by the focal lens position relative to the sample. It also determines the width of the modified version of the sample with varying depths, whereby if needed partial or full overlapping of the treated areas is performed. The process of structuring the sample takes place under normal room conditions and air environment unless it is necessary to obtain more sophisticated and more specific structures with optimization for specific purposes / types of samples tested and their aggregate state - liquid phase, gel, cellular culture, etc.). The obtaining of a certain contour and duration of action is controlled by the movement of the X-Y table on which the sample is attached. The structure for surface-enhanced Raman scattering is of niobium in the form of a metal disk or plate as well as a complex structure of different composite layers of various metals, their oxides or nitrides with the top layers of niobium and niobium oxides and is intended for application in medicine, pharmacology, biology, biotechnology, ecology, industry, research, etc. The invention provides for structures having different configurations, area, depth, nanomorphology and desired functionality for the absorption of compounds, cell metabolites, etc. as well as an opportunity for their identification. 5 claims, 8 figures
Patent BG-113300-A (BG)
Title: Submerged semi-submersible hydrokinetic turbine with self-adjusting hinged semi-permeable blades with gravity amplification
Inventor: ATANASOV PAVEL
IPC: F03B17/06
Filed: 2021-01-13
Abstract: It is designed for round-the-clock power generation on account of hydrokinetic energy in natural river water currents and gravity. The main advantages of the gravity-assisted submerged semi-submersible hydrokinetic turbine according to the invention are that it is highly efficient and has a simplified design which makes it relatively low cost for zero emission power generation. Its energy-technical advantage is that the movement of the blades, relative to their pivot joints, takes place under the action of gravity. They are therefore always oriented vertically underwater, thereby scooping up many times more water from the stream than similar equipment. A submerged semi-submersible hydrokinetic turbine with gravity-assisted self-adjusting hinged semi-permeable blades, comprising a turbine shaft (1) around which is mounted a cylindrical rotor (2) to the surface of which are mounted hinged blades (3), by means of pivot joints (4), characterized by the fact that the cylindrical rotor (2) is symmetrically coaxially mounted around the turbine shaft (1), the blades (4) are semi-permeable and have mounted weights (5) at their peripheral ends.
Patent CN-1492148-A (CN)
Inventor: TAI-MIN KIM
IPC: F04B39/14
Filed: 1996-11-15
Abstract: 密封式压缩机的安装吸气噪音消声器的装置，它能使吸气噪音消声器在气缸盖上的安装更简单，从而减少制造工序的数量，提高密封式压缩机的生产率。该装置包括：一个整体地连接在吸气噪音消声器的上端的吸气噪音消声器盖，在这个盖的上表面上有预定高度的突出部分；以及一个将上述吸气噪音消声器安装在上述气缸盖的一部分上的固定构件。
Patent CN-1473042-A (CN)
Inventor: TAKAFUMI KOHAMA
IPC: A61K31/505
Filed: 2001-08-29
Abstract: 本发明涉及用于同时给予或者间隔时间分别给予N－(1－辛基－5－羧甲基－4，6－二甲基二氢吲哚－7－基)－2，2－二甲基丙酰胺或其可药用盐以及HMG－CoA还原酶抑制剂的药物组合物。
Patent CN-1459894-A (CN)
Title: 双波长钕激光器腔外倍频、和频的红绿蓝三基色激光器
Inventor: SHEN HONGYUAN
IPC: H01S3/00
Filed: 2002-05-21
Abstract: 双波长钕激光器腔外倍频、和频的红绿蓝三基色激光器，涉及一种产生红绿蓝三基色激光的新技术，它是基于钕激光晶体中钕离子 4 F 3/2 － 4 I 13/2 和 4 F 3/2 － 4 I 11/2 跃迁产生的1.3微米和1微米波段辐射的双波长激光通过腔外倍频获得红色和绿色激光，然后再由剩余的1.3微米激光与红色激光在腔外和频获得蓝色激光，通过控制两种基波激光输出功率的比例和腔内声光调Q，实现高效、均衡、同时输出的红绿蓝三基色激光。利用上述技术产生三基色激光，设备简单、成本低，可作为激光彩色显示的光源，广泛应用于大屏幕、高清晰度彩色电视、激光表演、激光投影仪和指挥、监控、调度中心的大屏幕、高清晰度的彩色显示设备等彩色显示领域。
Patent CN-1435129-A (CN)
Title: 经预处理的叶子的加工方法与将其用于食品的加工方法
Inventor: TORU FUKUNAGA
IPC: A23L35/00
Filed: 2002-09-09
Abstract: 一种用于饮食的经预处理的叶子的加工方法，包括用鞣酸降解酶处理经预处理的叶子。
Patent CN-1582171-A (CN)
Title: 化学修饰胰岛素的肺部给药
Inventor: PATTON JOHN S
IPC: A61K47/48
Filed: 2002-05-21
Abstract: 本发明提供了具有活性的亲水聚合物修饰的胰岛素衍生物。本发明的胰岛素衍生物，从一方面说，适合于传送到肺部，并且与天然胰岛素相比，表现出显著改进的药代动力学和/或药效特性。
Patent CN-1561290-A (CN)
Title: 用于纺织的平面结构的丝网印花方法及实施该方法的装置
Inventor: JOHN RUSH
IPC: B41F13/04
Filed: 2002-09-23
Abstract: 本发明公开了一种用于纺织的平面结构(1)、尤其是织物带的丝网印花方法。在该方法中利用在其外壳面中具有至少一个供印花介质透过用的圆周部段的连续旋转的印花滚筒(2)，将至少一个代表印花图案的图形印制在所述平面结构(1)上。为了沿印花滚筒的切线方向印制印花图案，所述纺织的平面结构(1)移动至由印花滚筒确定的印制位置处保持与该印花滚筒(2)有效连接以及在印制后脱开有效连接。为此，为了印制每种印花图案使所述纺织的平面结构(1)步进式地向前和向后移动。本发明还公开了一种用于实施所述方法的装置，该装置包括一具有用于将所述平面结构通过步进式地向前和向后运动调整到所述印制位置上的可逆驱动装置(11)的输送装置(4)。
Patent CN-1530333-A (CN)
Inventor: SUN XIAOBIN
IPC: C02F1/48
Filed: 2003-03-14
Abstract: 本发明的目的就在于提供了一种海水淡化设备——微波能海水淡化设备，包括微波源和反应器两个部分。微波源包括微波发生器、波导管、水负载、调节螺栓。反应器由壳体、排气口、进水口、出水口、微波输入口、缓冲室、反应室、弯管、混合室、排空管以及设于海水进口处和出口处、排气口处的微波屏蔽器，设于微波输入口处的密封屏蔽器组成。海水能够连续不断地进入微波场中，利用快速、均匀、节能、清洁等微波处理特点，对海水进行处理，能有效降低海水中的盐分，使其淡化，是海水淡化技术中最实用的一种。
Patent CN-1530472-A (CN)
Inventor: LIANG ZHONGQI
IPC: C03C19/00
Filed: 2003-03-10
Abstract: 本发明是一种电浆蚀刻夹框的改良，其是由框壁所围组而成的夹框，顶部与底部俱为开放端，且其尺寸不小于工作件的尺寸，底部则设升降连结装置；夹框围套工作件，当升降连结装置连结于升降装置并为升降时，改变夹框与工作件的空间，进而改变其内的电浆离子浓度。
Patent CN-1470930-A (CN)
Inventor: MASAHIRO TANAKA
IPC: G09G3/20
Filed: 2003-06-27
Abstract: 一种显示装置，带有一个象素阵列，其中沿第一方向和第二方向两维排列多个象素，其中交替地反复：用来沿第二方向顺序选择象素行的每Y行N次，并且把一个图像信号施加到为属于所选择的象素行的每Y行的象素的每一个中提供的电极对的一个上；用来沿第二方向顺序选择象素行的每Z行M次，并且把一个消隐信号施加到为属于所选择的象素行的每Z行的象素的每一个中提供的电极对的一个上，而Y、N、Z、和M是满足关系M＜N和Y＜N/M≤Z的自然数，并且在象素每一个中的电极对的另一个保持在基准电压下；及对于供给到象素列的每一个的消隐信号相对于基准电压的极性，反转为供给到消隐信号之后的每一个像素列的图像信号的极性，从而防止水平带条出现在由象素阵列显示的图像中。
Patent CN-1497172-A (CN)
Inventor: HISAO KUWABARA
IPC: F03B3/10
Filed: 2003-09-26
Abstract: 本发明的目的在于提供一种即使在水轮启动时的同步控制阶段，运转点进入到了S形特性的第2部分那样的恶劣条件下，也能够进行调速器的旋转速度控制，能够使可以进行同步、并联的落差范围大幅度扩大到低落差侧的涡轮机。控制转子的旋转速度的调速器具有在进行规定落差以下的发电模式启动时，在使转子的旋转速度与系统频率同步的同步控制阶段，使上述旋转速度的控制系统中的微分运算元件的影响度与其他运算元件的影响度相比，处于支配地位的控制模式。
Patent CN-1522221-A (CN)
Inventor: ISHII TAKASHI
IPC: B66B7/08
Filed: 2003-04-11
Abstract: 提供一种无设备间电梯，在减少升降路径底部的井深的同时，可在轿厢上部集中进行维修作业，并且，可减少顶部间隙口在轿厢10的上部设置左右一对厢侧滑轮16L、16R，同时，牵引滑轮17和左右一对厢侧滑轮16L、16R的旋转轴线一起向前后方向延伸。另外，自由旋转地支撑左右一对厢侧滑轮16L、16R的滑轮支撑梁15配置在厢框的上梁13和轿厢10的顶部面之间的间隙中，并且，配置在厢侧滑轮16L、16R的旋转轴的下方。
Patent CN-1650614-A (CN)
Inventor: MIYUKI OKADA
IPC: H04N9/04
Filed: 2003-03-05
Abstract: 提供了一种摄影设备和一种色差校正方法，其中即使在同时执行摄像机振动校正时，也能执行令人满意的校正处理。由选择器开关5选择来自摄像机信号处理电路4的输出信号，并提供到色差校正单元6。另一方面，利用传感器7P、7Y检测由于摄像机振动引起的角速度，并将该检测信号提供到控制微计算机8中的摄像机振动校正矢量计算单元9。将摄像机镜头1的驱动状态，例如变焦长度和焦点位置，提供到转换率计算单元10。从该摄像机振动校正矢量获得摄像机镜头1的以光轴为中心的偏移矢量，并将其提供到上述单元6。将每种颜色的转换率提供到上述单元6。由数据压缩电路15压缩由上述6校正的信号，并提供到记录和再现单元17的记录介质以进行记录。由数据扩展电路18对这样再现的信号进行解压，并提供到选择器开关5。因此，通过处理捕获的图像信号，可补偿小型摄像机镜头中引起的图片质量恶化，并且即使在同时执行摄像机振动校正时，也能执行令人满意的校正处理。
Patent CN-1656807-A (CN)
Inventor: GEROVAC BRANKO J
IPC: H04N7/24
Filed: 2003-05-02
Abstract: 一种剪辑多媒体流的方法，剪辑多个源多媒体流的多个段形成可能的多个输出多媒体流中的任意一个。剪辑流包括计算用于插入相继的段之间形成任意输出流的流的片断。根据此方法，源MPEG流内创建转场点所要求的计算可作为一个预过程大量进行，该过程产生可存储用于以后流剪辑的数据，流的剪辑要求相对较少的计算，可由相对廉价的设备完成，如软件。
Patent CN-1659478-A (CN)
Inventor: ROLAND KAPLAN
IPC: G03F7/20
Filed: 2003-04-11
Abstract: 本发明涉及一种用于把掩模(1)投影到衬底(2)上的方法，其中借助于一个照明单元(8)和一个光学单元(9)把所述掩模(1)投影到所述衬底(2)上。此外本发明还涉及一种用于执行所述方法的装置。应如下构造所述方法和装置，即用高的工作可靠性把所述掩模(1)及其小结构精确地投影到所述衬底(2)上，其中应校正所述衬底(2)的变形。本发明建议：相对于所述掩模(1)和所述衬底(2)移动所述照明单元(8)和所述光学单元(9)，测定所述衬底(2)的变形，以及根据所测定的变形借助于所述光学单元(9)使所述掩模(1)的图像变形并且匹配所述衬底(2)的变形。
Patent CN-1663275-A (CN)
Inventor: ROBERTS DAVID K
IPC: H04N7/24
Filed: 2003-06-12
Abstract: 公开了一种方法(2)、一种设备、一种计算机可读介质、以及使用所述方法用于验证诸如数字图像或者视频的音频视频信号(10)。从所有的图像区域，包括具有平面内容或者不可加水印的内容的区域中导出签名。通过组合来自于音频视频信号的所有区域的签名位并且将该签名位扩散到整个音频视频信号或者至少其大部分区域上，优选的是应用扩展频谱加水印技术(2.40)，能够校验平面区域的真实性。
Patent CN-1671646-A (CN)
Inventor: WEI-YANG SU
IPC: C07C211/11
Filed: 2003-07-21
Abstract: 本申请公开一种使伯胺还原性烷基化形成仲胺的方法，该方法在含有金属钯的催化剂存在下，通过伯胺与烷基化试剂和氢的高压反应进行。本发明方法的特征在于高的转化率和高的选择性，在第一次通过反应器后转化率和选择性均高于95％。按照优选实施方式，所产生的仲胺具有至少一个与伯胺产品的氮原子键合的2－烷基。
Patent CN-1672426-A (CN)
Inventor: DER TOL ERIK B VAN
IPC: H04N7/50
Filed: 2003-07-16
Abstract: 基于变换的编码器常用于数据信号处理领域。本发明涉及一种用于从基于变换的编码器或解码器内的第一功能组件(3、4、7、12、14)向所述编码器或解码器内的第二功能组件(4、5、7、8、14、15)传送至少一个数据块的方法，其中数据块包括行列结构的数据系数。编码器和解码器的各个组件之间产生大量的通信工作。本发明的目的在于减少此类工作量，方法是通过消除(31)一个或多个行和/或列的实质为零值的系数来缩减所述至少一个数据块的大小以生成缩减了大小的数据块，并将缩减了大小的数据块传送(32)到所述第二功能组件，从而在解码或编码方案中的各个不同功能单元之间只传送数据块的笛卡尔边框内的非零系数。
Patent CN-1701563-A (CN)
Inventor: GEORGE EGLIN MATTHEW
IPC: G16H10/60
Filed: 2003-05-02
Abstract: 本发明公开了一种无线虚拟局域网(VLAN)和一种经可独立于无线VLAN的第二网络选择性地连接到无线VLAN的装置。该装置能够至少连接到该无线VLAN并可连接到第二无线网络。无线VLAN接入点各自连接到以太网汇聚交换机，该交换机可感知VLAN，并将来自连接接入点的客户业务与接入VLAN相匹配。无线VLAN交换机维护接入VLAN与核心VLAN之间的关联表。第二无线网络可经因特网或专用网络远程连接到隧道端点。隧道端点连接到VLAN交换机，该交换机使用关联表管理连接装置与接入VLAN和适当核心VLAN上其它移动台之间自由形式的客户业务。
Patent CN-1052422-A (CN)
Inventor: CHARLTON JOHN
IPC: A24D3/16
Filed: 1990-09-25
Abstract: 一个烟雾过滤器，它包括每个预涂有颗粒吸附剂
(例如活性炭细粒)的基底细丝和/或狭条，把它们聚
集成实心或管状形状(例如在装载塞筒内)，被聚集在
一起的细丝/或狭条形成一个管状体时，就可以有一
个芯。
Patent CN-1055235-A (CN)
Title: 冷藏设备
Inventor: MACHI HUMIHARU
IPC: F25D3/00
Filed: 1991-03-23
Abstract: 冷藏设备具有包括许多相互重叠的堆积层并限
定一冷藏空间的夯实土层，许多由土建织物制成的加
强保持片插入夯实土层的各层之间以保持夯实土层
的稳定。充有冷却剂的热管的一部分埋入到冷藏空
间周围相邻的夯实土层中，热管的另一部分从夯实土
层向上突出伸展。
Patent CN-1075776-A (CN)
Title: 热机
Inventor: HIROSHI SEKITANI
IPC: F25B9/14
Filed: 1992-12-09
Abstract: 改变热机的高温室和高温部分的中温室的排气
量，或者另外的方式，改变低温室和低温部分的中温
室的排气量。
Patent CN-1092738-A (CN)
Inventor: YUNXIAO FAN
IPC: B66B17/30
Filed: 1993-03-24
Abstract: 一种用于矿山立井提升运输中载荷检测方法与
监控系统，主要是在提升容器上，安装载荷传感器，通
过载荷传感器将提升载荷转换为电信号，由发射器经
提升钢丝绳发射到井上。井上由接收器把载荷信号
接收下来，送给由单片机系统组成的主机，单片机系
统根据载荷的大小和变化情况诊断过载、卡罐和松绳
故障，发出相应的报警显示和报警声响信号，并自动
控制提升机的运行状态，防止事故的发生，起到保障
安全生产的目的。
Patent CN-1077455-A (CN)
Title: 4位取代青蒿素类似物
Inventor: YAJING RONG
IPC: C07D493/18
Filed: 1993-03-25
Abstract: 本发明设计并合成4位取代青蒿素类似物，4位
是最靠近青蒿素活性中心的部位，因而它将是一类具
有独特生理活性的化合物，将发展为一类新的药物。
Patent CN-1089213-A (CN)
Inventor: BENEDIKT GEORGE M
IPC: B32B27/32
Filed: 1993-12-24
Abstract: 由不少于一个固定于导电表面上并以聚降冰片

烯涂覆的基底构成的聚降冰片烯半固化片制得的层

压制件。聚降冰片烯半固化片和导电表面间的粘接

力，可通过用硅烷偶联剂处理导电表面来涂覆和/或

在它们间加入一层聚烯烃膜得到改善。为改善或降

低介电常数，可在制备聚降冰片烯半固化片的浸渍浴

中加入聚烯烃粉末。制备半固化片，采用层压法制或

层压制件。一个或多个铜箔也可用在半固化片的外

表面之间或用在层压制件的外表面上。
Patent CN-1128722-A (CN)
Title: 包装物品、方法和机械
Inventor: MORRIS JOHN WILLIAM
IPC: B65B25/00
Filed: 1995-02-10
Abstract: 一种包装物，其包括一个波纹纸的卷，这个卷是由绕在其本身上的单面波纹纸的单个段所形成的，因此，这段长度的一端位于卷的内部，另一端位于卷的外部。
Patent CN-1157140-A (CN)
Title: 一种以文蛤提取物为主要药物成分的胶囊及其生产方法
Inventor: WANG KELIU
IPC: A61K35/618
Filed: 1996-02-12
Abstract: 本发明提供了一种以文蛤提取物为主要药物成分的胶囊及制造方法，文蛤提取物中含有文蛤核酸、蛋白质及少量糖分，取文蛤提取物、蔗糖、淀粉过筛、混合，分装即可制成胶囊，这种胶囊服用方便，治疗效果好，能有效抑制肿瘤生长，对化疗过程中的白细胞减少具有升白作用，能显著提高机体免疫力。
Patent CN-1206024-A (CN)
Title: 运动鞋之后帮用的树脂组合物
Inventor: KANG JUNG-GIL
IPC: C08L31/00
Filed: 1998-07-21
Abstract: 本发明涉及运动鞋之后帮用的树脂组合物,该组合物包括α－烯烃单体的均聚物和α－烯烃单体与乙酸乙烯酯基单体、α,β－不饱和羧酸或其酯的共聚物,以及必要的无机填料,该组合物具有良好的强韧机械性质、硬度和加工性。
Patent CN-1280550-A (CN)
Title: 生产四氯化硅基的有机改性的气凝胶的方法
Inventor: SCHWERTFEGER F
IPC: C01B33/158
Filed: 1998-11-25
Abstract: 本发明涉及一种制备基于四氯化硅的有机改性气凝胶的方法,其中:a)通过将四氯化硅与水直接反应而得到水凝胶,b)将步骤a)中所得到的水凝胶进行表面改性,然后c)干燥在步骤b)中所得到的表面改性凝胶。
Patent CN-1241446-A (CN)
Title: 防火毯和其它含有蜜胺树脂的组合物和具有防火性质的产品
Inventor: KENT GEORGE M
IPC: D04H1/46
Filed: 1999-03-06
Abstract: 用三聚氰胺树脂纤维、芳族聚酰胺纤维和/或改性聚丙烯酸纤维的混合物生产的组合物和产品,它们具有优异的防火特性,以及高强度,极好的加工性能,和使最终用户感到舒适的特性。
Patent CN-1251912-A (CN)
Title: 用于对比度提高的投影显示器的改进的x立方体结构
Inventor: DENIS F E
IPC: G02B27/14
Filed: 1999-09-29
Abstract: 公开了一种诸如液晶显示装置的光学投影显示系统。本发明的特征在于该投影显示系统来用一种改进的X立方体(或X棱镜)装置,其中形成改进的X立方体棱镜的内角偏离90°。本发明改进的X立方体装置的使用,可提高黑白格图象的对比度,把因进入投影透镜而产生无用的寄生反射的可能性降到最小,并基本上消除了使用现有X立方体时通常出现的眩光和幻象。
Patent CR-20120544-A (CR)
Title: Mezclas fungicidas i que comprenden quinazolinas
Inventor: MUELLER BERND
IPC: A01N63/38
Filed: 2012-10-24
Abstract: La presente invención se refiere a mezclas fungicidas, que comprenden por lo menos un compuesto I de quinazolina y un compuesto II como se define en la descripción, y a composiciones que comprenden estas mezclas.
Patent CR-20200450-A (CR)
Title: Anti-trem-1 antibodies and uses thereof
Inventor: PASHINE ACHAL
IPC: C07K16/28
Filed: 2019-04-01
Abstract: <p>Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.</p>
Patent CR-20200477-A (CR)
Title: Novel peptides and combination of peptides for use in immunotherapy against various tumors
Inventor: STEVERMANN LEA
IPC: C07K14/47
Filed: 2016-03-24
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent CR-20220016-A (CR)
Title: 6,7-dihydro-5h-pyrido[2,3-c]pyridazine derivatives and related compounds as bcl-xl protein inhibitors and pro-apoptotic agents for treating cancer
Inventor: HERNER ANDRÁS
IPC: C07D487/04
Filed: 2020-07-28
Abstract: The present invention discloses 6,7-dihydro-5H-pyrido[2,3- c]pyridazine, 1,2,3,4-tetrahydroquinoline, 1H-indole, 3,4- dihydro-2H-1,4-benzoxazine, 1H-pyrrolo[2,3-b]pyridin-1-yl, 7H- pyrrolo[2,3-c]pyridazine, 5H,6H,7H,8H,9H-pyridazino[3,4-b]azepine derivatives and related compounds of formula (I) as Bcl-xL protein inhibitors for use as pro-apoptotic agents for treating cancer, autoimmune diseases or immune system diseases. Formula (I). The description discloses the preparation of exemplary compounds (e.g. pages 113 to 354 examples 1 to 221) as well as pharmacological studies with relevant data (e.g. pages 355 to 367; examples A to E; tables 1 to 5). Exemplary compounds are e.g. 2-{6-[(1,3-benzothiazol-2-yl) amino]-1,2,3,4-tetrahydroquinolin-1-yl}-1,3-thiazole-4-carboxylic acid (example 1) or e.g. 3-{1-[(adamantan-1-yl)methyl]-5- methyl-1H-pyrazol-4-yl}-6-{3-[(1,3-benzothiazol-2-yl)amino]-4- methyl-5H,6H,7H,8H-pyrido[2,3-c]pyridazin-8-yl]pyridine-2-carboxylic acid (example 24).
Patent EC-SP003572-A (EC)
Title: Androgenos oralmente activos
Inventor: LEYSEN DIRK
IPC: A61K31/56
Filed: 2000-07-13
Abstract: Nuevos adrógenos oralmente activos son derivados de A14-nandrolona 7-A-sustituidos. Los compuestos satisfacen la fórmula general: (gráfico), donde R1 es O, (H;H), (H,OR), NOR, siendo R hidrógeno, (C1-6) alquilo o (C1-6) acilo; R2 se selecciona del grupo consistente en (C2-4) alquilo, (C2-4) alquenilo o (C2-4) alquinilo, cada uno opcionalmente sustituido por halógeno; o R2 es ciclopropilo o ciclopropenilo, cada uno opcionalmente sustituido por (C1-2) alquilo o halógeno; R3 es hidrógeno, (C1-2) alquilo halógeno; R3 es hidrógeno (C1-2) alquilo o etinilo; R4 es (C1-2) alquilo; R5 es hidrógeno o (C1-15) acilo; y las lineas de puntos indican enlaces opcionales.
Patent EC-SP045094-A (EC)
Title: Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor de glucagon y sus metodos de uso farmacologico
IPC: C12N1/15
Filed: 2004-05-05
Abstract: La invención provee polipéptidos que actúan como agonistas del receptor del GLP-1 y como antagonistas del receptor del glucagón. Dichos polipéptidos son útiles para el tratamiento de individuos con diabetes tipo 2 u otros trastornos metabólicos.
Patent EC-SP055547-A (EC)
Title: Derivados de piperidina novedosos
Inventor: BLUMBERG LAURA COOK
IPC: A61P9/00
Filed: 2005-01-18
Abstract: Un compuesto de fórmula. en el que a, b, c, R1, R2, R3, R4, R5, R6, R7, Q, W, Y y Z son como se define anteriormente, útiles como inhibidores potentes y selectivos de la unión de MIP-1a (CCL3) a su receptor CCR1 que se encuentra en las células inflamatorias e inmunomoduladoras (preferiblemente leucocitos y linfocitos).
Patent EC-SP982388-A (EC)
Title: Gancho de resorte protegido
Inventor: KLEIN RICHARD T
IPC: F16B45/00
Filed: 1998-01-29
Abstract: Un gancho de resorte equipado con fijador incluye un miembro de protección que puede ser ubicado fácilmente por un usuario en un posición cerrada o una posición abierta. En la posición cerrada, el fijador está asegurado en un canal perfilado en U provisto por el miembro de protección para proteger al fijador del accionamiento no intensional o inadvertido. En la posición abierta el fijador está expuesto para su prontaactivación a una posición abierta por el usuario para instalar el gancho de resorte sobre un aro en D o remover el gancho de resorte desde el mismo o similares. Un actuador de leva en el cuerpo de gancho y una superficie de leva en el miembro de protección en las posiciones abiertas y cerrada para facilidad de uso durante la instalación o remoción del gancho de resorte.
Patent EC-SP982613-A (EC)
Title: Derivados de hydroxicumaranona o sustituida como agentes antitumorales y antimetastasicos
Inventor: DI DOMENICO ROBERTO
IPC: A61K31/34
Filed: 1998-08-03
Abstract: Se describe una benzocumaranona hidroxi substituida de formula general (I): en donde, R, R'' , A, B y T tienen los significados descritos en la especificacion y x es 0 o 1. En particular, B es un radical diamina, piperazina o piperidina. Se describe tambien el empleo de los compuestos de formula (I) como inhibidores de la union uPA al receptor especifico uPAR y en particular, su aplicacion como agentes antitumorales y antimetastasicos
Patent FI-20010534-A (FI)
Inventor: TUOVINEN OLLI
IPC: D21B1/28
Filed: 2001-03-16
Abstract: The invention relates to a grinding segment comprising a ceramic part manufactured of grinding ceramic material and provided with a fastening hole, through which the grinding segment is attached to a frame of a grinder stone by means of a fastening bolt. A fastening sleeve is arranged in the fastening hole, and the fastening bolt is supplied through the sleeve. The fastening sleeve is pressed against the frame of the grinder stone due to the fastening force. A space filled with bonding agent is formed between the ceramic part of the fastening sleeve to join them together. The invention further relates to a grinder stone comprising a cylindrical frame and grinding segments according to the invention.
Patent FI-20020162-A (FI)
Inventor: HUOTARI HARRI
IPC: B42C9/00
Filed: 2002-01-29
Abstract: The invention relates to a method and device for hot-gluing a bundle ( 2 ), particularly in a device that includes a glue reservoir ( 7 ) for storing a glue that has been made fluid, a glue-spreading roller ( 6 ) for spreading the glue onto the spine surface of the bundle ( 2 ), press devices, ( 3,4,5,2 1, 21 ') for holding the bundle ( 2 ), and possible side-nip devices ( 16, 19, 20 ) for finishing the shape of the book. The bundle ( 2 ), which is held between two symmetrically positioned press plates ( 21, 21 '), is pressed with the glue-spreading roller ( 6 ) to bend or fan out the edge of the bundle ( 2 ) and to open a gap between the cover sheet ( 11 ) and the outermost sheet of the bundle. The glue is spread to such an extent that a glue bead ( 13, 14, 15 ) forms at the gap and at the opposite edge of the bundle ( 2 ) and possible also at the bend in the cover sheet, so that the glue beads are spread for a certain distance in the gaps between the cover ( 11 ) and the edges of the bundle, in order to form a glue bond during the following side nipping.
Patent FI-20175029-A (FI)
Title: Measurement device with motion sensing
Inventor: KIVIJÄRVI JANNE
IPC: G01R27/00
Filed: 2017-01-16
Abstract: The present disclosure concerns a moisture concentration measurement device with an elongated measurement probe (12) configured to be moved in a body of pressed biomaterial (151) when moisture concentration measurements are performed. Before or after the probe (12) is moved, the control unit (118, 119, 120) initiates a moisture concentration measurement and reads an initial moisture concentration value from the moisture sensor. The control unit (118, 119, 120) then calculates a moisture concentration correction factor based on correction variables which include at least the estimated dynamic force and the biomaterial. The control unit (118, 119, 120) can calculate an adjusted moisture concentration value by adjusting the initial moisture concentration value with the moisture concentration correction factor,
Patent FR-1570371-A (FR)
IPC: B29C48/67
Filed: 1968-07-01
Granted: 1969-06-06
Abstract: 1,202,301. Mixing apparatus. WERNER & PFLEIDERER. 23 May, 1968 [29 July, 1967], No. 24686/68. Heading B1C. . . Apparatus for continuously and consecutively mixing and plasticising plastics material comprises a mixing section 1 and plasticising section 2, the former section being divided into mixing zones 1a, 1b, lc alternating with conveying zones Id, 1e, 1f. Plastics material is fed from hopper 3 into casing 6 and is conveyed by rotatable screw or intermeshing screw elements through sections 1, 2. The mixing zones may be formed by the cutting of channels in the conveying screw element or intermeshing screw elements so that substantially no conveying action compared with the rate of throughput of material occurs in these zones. Additional components may be introduced into the casing through inlets 4 and the casing may be provided with fixed flights for co-operating with the rotable screw elements. The screw shaft(s) and the walls of the casing may be constructed so as to allow the passage of heat transfer media therethrough to cool the material being processed. The plasticising section may comprise screw elements.