baber/WOPTO huggingface dataset:
Patent NZ-622174-A (NZ)
Title: Glucagon-like peptide-2 compositions and methods of making and using same
Inventor: SCHELLENBERGER VOLKER
IPC: A61K38/26
Filed: 2012-09-12
Abstract: Disclosed is a composition for use in achieving an intestinotrophic effect in a subject comprising a recombinant fusion protein comprising (i) a glucagon-like protein-2 (GLP-2) sequence selected from the group consisting of the sequences of SEQ ID NOS: 1 and 3-23, and (ii) an extended recombinant polypeptide (XTEN), wherein the XTEN is a sequence exhibiting at least 90% sequence identity to a sequence selected from the group consisting of the sequences in Table 4, and wherein the XTEN is further characterized in that: (a) the XTEN comprises at least 36 amino acid residues; (b) the sum of glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P) residues constitutes more than 80% of the total amino acid residues of the XTEN; (c) the XTEN is substantially non-repetitive such that (i) the XTEN contains no three contiguous amino acids that are identical unless the amino acids are serine; (ii) at least 80% of the XTEN sequence consists of non-overlapping sequence motifs, each of the sequence motifs comprising 9 to 14 amino acid residues consisting of four to six amino acids selected from glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P), wherein any two contiguous amino acid residues do not occur more than twice in each of the non-overlapping sequence motifs; or (iii) the XTEN sequence has a subsequence score of less than 10; (d) the XTEN has greater than 90% random coil formation as determined by GOR algorithm; (e) the XTEN has less than 2% alpha helices and 2% beta-sheets as determined by Chou-Fasman algorithm; and (f) the XTEN lacks a predicted T-cell epitope when analysed by TEPITOPE algorithm, wherein the TEPITOPE threshold score for the prediction by the algorithm has a threshold of –9, wherein the fusion protein exhibits an apparent molecular weight factor of at least 4 and is capable of achieving an intestinotrophic effect in a subject using a dosage of 2.5 nmol/kg to 6250 nmol/kg, or 25 nmol/kg to 3750 nmol/kg, or 75 nmol/kg/dose to 1250 nmol/kg/dose, or 125 nmol/kg/dose to 750 nmol/kg/dose.
Patent NZ-623292-A (NZ)
Title: Guanidinyl-substituted polyamides useful for treating human papilloma virus
Inventor: BASHKIN JAMES K
IPC: C08L77/00
Filed: 2012-10-10
Abstract: The disclosure relates to guanidinyl-substituted polyamides of the abstract figure, wherein m is 5-12; n is 4-10; G is a guanidinyl radical; each X is independently selected from 4-amino-2-carbonyl-N-methylimidazole, 4-amino-2-carbonyl-N-methylpyrrole or 6-alanine; gammaq is g-aminobutyric acid, 2,4-diaminobutyric acid or H2N(CH2)2CH(NHC(=O)NHR)CO2H, wherein R is -(CH2)3-N(CH3)-(CH2)3-NH2 or -(CH2)3-N(CH3)2 and A is 3,3’-diamino-N-methyldipropylamine or 3-(dimethylamino)propylamine. The disclosure also relates to their use for binding double-stranded DNA in a sequence-specific manner and treating cancer and an infection is caused by HPV, Epstein-Barr viruses, herpes viruses, adenoviruses, BK and pox viruses.
Patent NZ-625110-A (NZ)
Title: Asphalt compositions having improved properties and related coatings and methods
Inventor: SUBOTIC DUSAN V
IPC: E01C21/00
Filed: 2012-11-29
Abstract: Disclosed is a composition to coat a substrate comprising: an asphalt material; a polyol; and a polymer that is not a polyol (e.g., styrene butadiene styrene (SBS)). The polyol has a molecular weight of about 1000 to about 5000 and/or the polyol is present in an amount no greater than about 30% by weight of the total composition. Also disclosed are methods of improving the processability of an asphalt material comprising combining together an asphalt material, a polyol and a polymer that is not a polyol, wherein the resultant composition exhibits improved process ability as compared to an asphalt composition that does not contain a polyol.
Patent NZ-627075-A (NZ)
Title: A contouring device
Inventor: ROGER THOMAS MASCULL
IPC: B68G7/06
Filed: 2013-07-05
Abstract: A contouring device (1) for a seat base, backrest, or mattress, comprising a substrate (2) having a first surface (7a) and an opposing second surface, the first and second surfaces each comprising a plurality of pockets (4) adapted to receive one or more inserts, and further comprising one or more inserts for placing within one or more of the pockets.
Patent NZ-630776-A (NZ)
Title: Method of nucleic acid fragmentation
Inventor: COGAN NOEL
IPC: C12N15/11
Filed: 2014-08-20
Abstract: The present invention provides a method of preparing an at least partially randomly sheared library of nucleic acids, said method including providing a source of nucleic acids, randomly incorporating modified cytosine bases into the nucleic acids, and digesting the modified nucleic acids with one or more modification-dependent restriction endonucleases to produce the nucleic acid library. Fragments may be 50-500 baases. the modified cytosine may be 5-methylcytosine, modified restricition endonucleases may be MspJI, PLNPI and FSPEI. The present invention also provides kits for performing the method, nucleic acid libraries prepared by the method and methods of next generation sequencing using the method.
Patent NZ-631278-A (NZ)
Title: Antimicrobial compositions and methods of use
Inventor: Sarika Namjoshi
IPC: A61P31/00
Filed: 2014-06-26
Abstract: Disclosed are pharmaceutical or veterinary compositions comprising at least one azole compound and at least one polymeric biguanide compound of formula I or III suitable for preventing infections of the skin or an epithelial lined cavity. In a preferred embodiment the azole compound is miconazole and the polymeric biguanide compound is polyhexamethylene biguanide.
Patent NZ-701102-A (NZ)
Title: Cushion for patient interface
Inventor: HITCHCOCK ROBIN GARTH
IPC: A61M16/06
Filed: 2006-01-12
Abstract: A cushion for a patient interface that delivers breathable gas to a patient, the cushion comprising: a base wall (28); and a face contacting portion (14) including a nasal bridge region (16), a pair of side of nose regions (17), a pair of upper cheek regions (18), a pair of a lower cheek regions (19), and a chin region (20). The face contacting portion is adapted to form a continuous seal on the patient’s face in use. The portion of the cushion between the face contacting portion and the base wall of the cushion is structured and / or arranged to provide a spring configuration in the nasal bridge region, a spring configuration in the pair of side of nose regions, and a spring configuration in the chin region. In use, the spring configuration(s) permit displacement of the respective face contacting portions from an initial position in response to a frame force applied to the cushion, and resiliently move the respective face contacting portions towards the initial position when the frame force is released. The spring configuration in the nasal bridge region is more flexible than the spring configuration in the pair of side of nose regions. The spring configuration in the chin region is more flexible than the spring configuration in the pair of side of nose regions.
Patent NZ-703879-A (NZ)
Title: Tomato fruit having increased firmness
Inventor: SEYMOUR GRAHAM BARRON
IPC: C12Q1/68
Filed: 2010-10-15
Abstract: Disclosed is a tomato fruit of a cultivated tomato plant with increased fruit firmness in the outer pericarp at the harvesting stage linked to at least one quantitative trait locus (OTL) in the cultivated tomato plant producing said tomato fruit, wherein said firmness is from between 1.2 to 2.0 times greater than that of fruit from a control tomato plant which does not have said at least one OTL, wherein the harvesting stage is the mature green stage, and wherein said plant can be characterised by: a) the at least one OTL is linked to at least one DNA marker selected from the group consisting of NT3853, NT3907, TG14, HOX7A, CT277, HB2600, TG353, Lm0127, Lm1650, LE5100 and LE5200; and/or b) the at least one OTL is complementary to the corresponding OTL in Solanum pennellii lines IL2-3 and IL2-4 deposited under accession numbers LA4038 and LA4039, respectively, wherein said at least one OTL in LA4038 and LA4039 is linked to at least one DNA marker selected from the group consisting of NT3853, NT3907, TG14, HOX7A, CT277, HB2600, TG353, Lm0127, Lm1650, LE5100 and LE5200; with the proviso that lines IL2-3 and IL2-4 are excluded. Also disclosed is a method for detecting a QTL linked to significantly increased fruit firmness in fruit from a cultivated tomato plant compared to a control tomato plant comprising the steps of a) crossing a donor tomato plant with a recipient tomato plant to provide offspring cultivated tomato plants; b) quantitatively determining the firmness in the fruit of said offspring plants; c) establishing a genetic linkage map that links the observed increased fruit firmness to the presence of at least one DNA marker from said donor plant in said offspring plants; and d) assigning to a QTL the DNA markers on said map that are linked to significantly increased fruit firmness, wherein at least one QTL is as defined in the complete specification.
Patent NZ-705875-A (NZ)
Title: Breathing assistance system with speech detection
Inventor: FROMENTIN CYRIL
IPC: A61M16/04
Filed: 2013-08-22
Abstract: Patients having a tracheostomy tube connected to a ventilator may experience impaired quality of speech during normal operation of the ventilator. Disclosed is a breathing assistance system (10) comprising: a ventilator (12), a breathing lumen (14) arranged to communicate a flow of air between the ventilator and a tracheostomy tube (16) in the trachea of a patient, and a sensor (24) configured to generate a vibration signal representing vocal cord vibrations of the patient. The system is configured to facilitate the flow of exhaled air to the atmosphere via the upper airway of the patient in response to detection in the vibration signal of speech or attempted speech by the patient.
Patent NZ-717880-A (NZ)
Title: Glucopyranosyl-substituted indole-urea derivatives and their use as sglt inhibitors
Inventor: FIELDS TODD
IPC: C07H19/044
Filed: 2014-10-28
Abstract: The present invention provides certain inhibitors of SGLT1 which may be suitable for the treatment of diabetes. In particular, the present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof.
Patent NZ-719509-A (NZ)
Title: A panel system and components therefor
Inventor: IAN WILLIAMS
IPC: E04F13/22
Filed: 2016-04-28
Abstract: Prior art cladding systems can be time consuming and use attachment means that can permanently damage panels. Provided herein is a panel system including at least one elongate first member extending in a first direction, a plurality of elongate second members extending in a second direction different to the first direction, each elongate second member including at least a pair of abutment shoulders, one on either lateral side edge of the elongate second member and each second member attached to the at least one elongate first member using at least one connection clip, each connection clip having a first pair of abutment surfaces extending in a first direction and adapted to engage with the at least one elongate first member and a second pair of abutment surfaces each provided on an arm and extending in a second direction to engage with the respective pair of abutment shoulders on the elongate second member in order to hold the elongate second member relative to the first member.
Patent NZ-720906-A (NZ)
Title: Orally disintegrating solid dosage unit containing an estetrol component
Inventor: PLATTEEUW JOHANNES JAN
IPC: A61K31/56
Filed: 2014-12-10
Abstract: The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight of 50-1,000 mg and containing at least 0.1 mg of an estetrol component selected from estetrol, estetrol esters and combinations thereof. This solid dosage unit consists of: 4-95 wt.% of granules consisting of: 3-80 wt.% of an estetrol component selected from estetrol, estetrol esters and combinations thereof; 20-97 wt.% C4 -C12 sugar alcohol; 0-45 wt.% of one or more other pharmaceutically acceptable ingredients; and 5-96 wt.% of one or more pharmaceutically acceptable excipients. The solid dosage units of the present invention are particularly suited for sublingual, buccal or sublabial administration of the estetrol component.
Patent NZ-721363-A (NZ)
Title: Production of cider with pichia kluyveri yeast
Inventor: SWIEGERS JAN HENDRIK
IPC: C12G3/02
Filed: 2015-02-04
Abstract: The present invention relates to the field of production of a beverage, especially cider, by fermentation of apple juice and/or pear juice. Specifically, the invention relates to a method of preparing a beverage with enhanced levels of desirable fermentation-derived flavor compounds comprising a step of fermentation of apple juice and/or pear juice with at least one Pichia kluyveri yeast strain, a beverage obtainable by the method and a cider comprising a high concentration of the flavor compound, hexyl acetate.
Patent NZ-721943-A (NZ)
Title: Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
Inventor: KIM JIN-HWAN
IPC: A61K39/09
Filed: 2015-01-15
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates)and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.
Patent NZ-722603-A (NZ)
Title: Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Inventor: DE FAVERI CARLA
IPC: C07D471/04
Filed: 2015-02-04
Abstract: The present invention discloses a 1:1 free base/maleic acid salt of a Compound 1: useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.
Patent NZ-723531-A (NZ)
Title: Crispr enabled multiplexed genome engineering
Inventor: GILL RYAN
IPC: C12N15/11
Filed: 2015-02-11
Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used. In particular, the present invention relates to a synthesized cassette comprising the following covalently-linked components: (i) a nucleic acid encoding a guide RNA (gRNA) sequence targeting a target region in a cell; (ii) at least one editing cassette comprising (a) a region homologous to a target region of a nucleic acid in a cell, (b) a mutation of at least one nucleotide relative to said target region, and (c) a mutated protospacer adjacent motif (PAM) that is not recognized by a CRISPR system.
Patent NZ-743568-A (NZ)
Title: Brake lining for a disc brake, disc-brake hold-down for brake linings of a disc brake
Inventor: NEUMANN ARTHUR
IPC: F16D55/2255
Filed: 2016-12-19
Abstract: Disk brakes are normally arranged as far to the outside of the vehicle as possible to save space. Parts of the disk brake are even situated within the braked vehicle wheel. At the same time it is desired that the disk brake be dimensioned to be as large as possible, in order to achieve a high level of braking power. However, this means that little clearance remains between the components of the disk brake and the vehicle wheel rotating around the brake. It is therefore not uncommon, when additional bending loads arise, for brake parts situated radially far to the outside to grind against the rotating inner surface of the vehicle wheel. The present invention seeks to contribute to a solution to the problem of the structural constriction between the components of the disk brake and the vehicle wheel rotating around the brake. In particular, the present invention provides brake pad for a disk brake, which brake pad is composed of a friction pad, which is designed to make contact with the brake disk of the disk brake, and of a backplate, the front side of which is formed as a fastening surface for the friction pad and the rear side of which is formed as a pressure surface for the transmission of the brake pressure, wherein the circumferential contour of the backplate is defined by an upper margin, a lower margin and two side margins extending between the upper and the lower margin, and also the circumferential contour of the friction pad is defined by an upper margin, a lower margin and two side margins extending between the upper and the lower margin, and wherein the upper margins of the backplate and of the friction pad each have a main profile which is interrupted, in the center between the two side margins of the backplate, by a depression of the upper margin in the direction of the lower margin of the backplate, wherein, on the rear side of the backplate, a projection is integrally formed, wherein the projection projects away from the rear side in a direction facing away from the front side, wherein the projection is arranged closer to the upper margin than to the lower margin of the backplate, and/or is equipped, for the purposes of support in a pad receptacle, with a support surface facing toward the lower margin, and/or is equipped with a hold-down surface which faces away from the support surface and which is arranged lower than the depression in the backplate.
Patent NZ-745788-A (NZ)
Title: Mobile voltammetric analysis
Inventor: HOGAN CONOR
IPC: G01N27/416
Filed: 2017-03-16
Abstract: A low-cost voltammetric analysis system using a mobile computing device (300) having a microprocessor (320), a memory (324) and an audio interface (332, 334). The audio interface comprises an audio signal output (332) having first and second channels and an audio signal input (334). The interface is connectible to a voltammetric cell (102) comprising first and second electrodes (104, 106), and the memory of the device contains instructions (336) which, when executed by the microprocessor, cause the device to: generate an output voltage waveform (310, 312) between the first and second channels of the audio signal output, the output voltage waveform comprising a time-varying voltammetric driving potential and an AC perturbation; simultaneously with generating the output voltage waveform, capture an input voltage waveform (314) received at the audio signal input; and record (420) the input voltage waveform as a voltammetric response waveform (314) within a data store (324).
Patent NZ-756528-A (NZ)
Title: Liquid-cooled intelligent alcohol fireplace
Inventor: XU WANG
IPC: F24C5/14
Filed: 2019-08-20
Abstract: A smart liquid-cooled alcohol fireplace comprises a fireplace body (1), an alcohol supply assembly (2), a liquid-based cooling assembly (3), and a circuit assembly (4), wherein the fireplace body (1) is formed by a housing (11), an alcohol storage tank (12), a combustion slot (13), and a panel (14). The alcohol supply assembly (2) comprises an alcohol storage container (21), an alcohol supply pipe (22), an alcohol input connector (23), an alcohol self-priming pump (24), a submersible pump (25), and an alcohol output head (26). The liquid-based cooling assembly (3) comprises a first cooling pipe (31), a second cooling pipe (32), a first cooling self-priming pump (33), a second cooling self-priming pump (34), a liquid coolant circulating pipe (35), and a liquid coolant storage container (36). The circuit assembly (4) comprises a starting switch (41), an ignition switch (42), a main control board (43), a spark electrode (44), a temperature sensor (45), a first liquid level sensor (46), and a second liquid level sensor (47), and a third liquid level sensor (48). The fireplace is automatically primed with alcohol during operation, automatically controls the level of alcohol in the combustion slot (13), automatically controls the temperature of the combustion slot (13) to control alcohol flame size, is easy and safe to use, conserves energy, and is environmentally friendly.
Patent NZ-759568-A (NZ)
Title: Cell cryopreservation formulation and cell recovery method
Inventor: ZHANG LI
IPC: A01N1/02
Filed: 2018-05-24
Abstract: The present invention relates to the preparation and use of a cell cryopreservation formulation convenient for clinical use. In particular, provided is a cell cryopreservation (freezing) formulation, comprising: (1) a cell; (2) a cryopreservation diluent, the cryopreservation diluent comprising: an aqueous solution of sodium chloride, protective proteins, and dimethyl sulfoxide. The present invention also involves a corresponding cell recovery method. The present invention uses a cryopreservation media requiring no washing to prepare a cell cryopreservation formulation, and cell recovery and dilution for clinical use can be performed by means of a simple preparation operation.
Patent OA-12508-A (OA)
Title: Fluids and techniques for hydrocarbon well completion.
Inventor: TIBBLES RAYMOND J
IPC: C09K8/52
Filed: 1999-12-08
Abstract: The Invention relates to novel fluids and techniques to optimize/enhance the production of hydrocarbon from subterranean formations (e.g., "completion fluids"), in particular, fluids and techniques are disclosed and claimed which remove wellbore damage and near-wellbore damage in the form of coating formed from drilling and production-related operations ("filtercake"); the techniques can be applied either by themselves or in conjunction with other completion operations, such as gravel packing; preferred embodiments are chelating agent and enzyme systems in a viscoelastic surfactant (VES) matrix.
Patent PT-100550-A (PT)
Title: Linear viscoelastic aqueous liquid detergent composition for automatic dishwashers containing a thickener of the cross-linked polyacrylic acid type
Inventor: DIXIT NAGARAJ SHRIPAD
IPC: C11D7/54
Filed: 1992-05-29
Abstract: This invention relates to a detergent composition for automatic dishwashers which is formulated as a linear viscoelastic pseudoplastic aqueous product of the gel type having exceptionally good physical stability when exposed to daylight, with little residue in the bottle, little loss in glasses and better cleaning performance. Linear viscosity and pseudoplastic behaviour are obtained by incorporating at least one thickener of the cross- linked polyacrylic acid type having a high molecular weight. Potassium to sodium ratios by weight of at least 1/1 reduce the quantity of undissolved solid particles to a minimum in order better to contribute to the stability and pourability characteristics of the composition. Control of the incorporated air bubbles has the function of giving the product a bulk density of between 1.35 g/cm3 and 1.40 g/cm3 which approximately corresponds to the density of the liquid phase. The presence of a stearic acid or other fatty acid or salt in the composition further improves its physical stability.
Patent PT-101760-A (PT)
Inventor: OSBORN THOMAS WARD III
IPC: D04H13/00
Filed: 1995-08-17
Abstract: Absorbent articles, especially sanitary napkins, contain fibers with intra-fiber capillary channels. In-use, the capillary channel fibers direct menses to a storage layer, thereby minimizing product failure and staining of undergarments. The capillary channel fibers can protrude into, or through, a topsheet to provide very aggressive transport of vaginal discharges.