Patent SG-11201906499X-A (SG)
Title: System and method with fiducials having offset layouts
Inventor: VIECELI JOHN S
IPC: G01N21/64
Filed: 2018-01-31
Abstract: IMAGINGSYSTEM DATA ANALYSIS SYSTEM W O 18/ 14457 4 Al FIG. 1 DEBLOCK STATION X14 DOWNSTREAM / 1R PROCESSING STORAGE SYSTEM 12 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT onion °nolo DID Mo IIH 100 m° im mom oimIE (10) International Publication Number WO 2018/144574 Al (51) International Patent Classification: GO1N 21/64 (2006.01) (21) International Application Number: PCT/US2018/016189 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701686.6 01 February 2017 (01.02.2017) GB (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, California 92122 (US). (72) Inventors: VIECELI, John S.; 1498 Flair Encinitas Dri- ve, Encinitas, California 92024 (US). NEMIROSKI, Alex; 5205 Fiore Ten, Apt. B410, San Diego, California 92122 (US). BELITZ, Paul; 5200 Illumina Way, San Diego, Cal- ifornia 92122 (US). LANGLOIS, Robert; 5200 Illumi- na Way, San Diego, California 92122 (US). BOWEN, M. Shane; 5200 Illumina Way, San Diego, California 92122 (US). CHAN, Danny Yuan; 5200 Illumina Way, San Diego, California 92122 (US). VENKATESAN, Bala Mu- rali K.; 499 Illinois Street, Suite 210, San Francisco, Cal- ifornia 94158 (US). HAN, Hui; 5200 Illumina Way, San Diego, California 92122 (US). SAMIEE, Kevan; 5200 Il- lumina Way, San Diego, California 92122 (US). TANNER, Stephen; 5200 Illumina Way, San Diego, California 92122 (US). (74) Agent: DIERKER, Julia Church et al.; Dierker & Ka- vanaugh, P.C., 3331 W. Big Beaver Road, Suite 109, Troy, Michigan 48084 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: SYSTEM AND METHOD WITH FIDUCIALS HAVING OFFSET LAYOUTS (57) : Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or im- - 12 prove processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the 24-1 FLUSH I array from one another in image data. STATION NUCLEOTIDE DELIVERY SYSTEM [Continued on next page] WO 2018/144574 Al MIDEDIMODOMMEN3010MOIVINEHMEMOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3))