baber/WOPTO huggingface dataset:
Patent IL-115091-A0 (IL)
Title: Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
IPC: C07D295/08
Filed: 1995-08-28
Abstract: The present invention provides a novel process for preparing a compound of formula I <CHEM>  wherein     R is C1-C4 alkyl; R<1> and R<2> each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidino, dimethylpyrrolidino, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; and     n is 2 or 3;  or a pharmaceutically acceptable salt thereof, comprising   a) condensing (C1-C4 alkyl) 4-hydroxybenzoate with ethylene carbonate or propylene carbonate in the presence of a condensation catalyst and a moderately polar, water immiscible solvent having a high boiling point;   b) reacting the product of step a), a compound of formula III <CHEM>  wherein     R and n are as defined above, with a leaving group donor; and   c) reacting the product of step b), a compound of formula IV <CHEM>  wherein     R and n are as defined above and X is a leaving group, with a base selected from the group consisting of piperidine, pyrrolidine, methylpyrrolidine, dimethylpyrrolidine, morpholine, dimethylamine, diethylamine, and 1-hexamethyleneimine.   The product of the above process, a compound of formula I, also is novel and is useful for the preparation of pharmaceutically active compounds of formula II, particularly via the following novel process   <CHEM>  wherein     R is C1-C4 alkyl; R<1> and R<2> each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidino, dimethylpyrrolidino, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; and     n is 2 or 3;  or a pharmaceutically acceptable salt thereof, comprising   a) condensing (C1-C4 alkyl) 4-hydroxybenzoate with ethylene carbonate or propylene carbonate in the presence of a condensation catalyst and a moderately polar, water immiscible solvent having a high boiling point;   b) reacting the product of step a), a compound of formula III <CHEM>  wherein     R and n are as defined above, with a leaving group donor;   c) reacting the product of step b), a compound of formula IV <CHEM>  wherein     R and n are as defined above; and X is a leaving group, with a base selected from the group consisting of piperidine, pyrrolidine, methylpyrrolidine, dimethylpyrrolidine, morpholine, dimethylamine, diethylamine, and 1-hexamethyleneimine;   d) reacting the product of step c) with a compound of formula IV <MATH> wherein R<3> and R<4> are as defined above, or a pharmaceutically acceptable salt thereof;   e) optionally removing the reaction product from step d) ; and f) optionally forming a salt of the reaction product from either step d) or step e).
Patent IL-130198-A0 (IL)
Title: Methods for purifying viruses
IPC: C12N7/02
Filed: 1997-12-11
Abstract: The invention provides methods for purifying a virus from impurities in an aqueous medium.
Patent IL-133249-A0 (IL)
Title: Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl) benzenes
IPC: C07F3/02
Filed: 1998-06-29
Abstract: A process of direct metalation of phenyltetrazoles useful for preparing compounds of formula (II) intermediates for the synthesis of angiotensin II antagonists is described.
Patent IL-146615-A0 (IL)
Title: Method and system for navigating a directory
IPC: G06F17/30
Filed: 2000-05-24
Abstract: A method and system for enabling navigation of a directory. The method includes printing a document containing a list of directory entries corresponding to at least one node of an index of the directory, with at least one user interactive element which enables a user to indicate a request for further directory information by interacting with the element using a sensing device which is adapted to transmit request data to a computer system; and printing the further directory information on a document.
Patent IL-148173-A0 (IL)
Title: Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
IPC: A61K38/00
Filed: 2000-08-17
Abstract: The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is:wherein:Z4 is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is:wherein:Z4 is any naturally occurring amino acid, excluding cysteine.
Patent IL-150325-A0 (IL)
Title: A method for the production of highly pure metallic nano-powders and nano-powders produced thereby
IPC: B22F9/16
Filed: 2002-06-19
Abstract: The present invention discloses a novel method for the production of metallic nano-powder. This cost-effective, simple process is customized for a full-scale production of metallic nano-powders containing a first metal, and comprising the following of forming an alloy comprising said first metal and at least one soluble metal; applying first thermal treatment in the manner homogenized alloy is obtained; applying a cold work to the homogenized alloy so thin strips are obtained; applying a second thermal treatment to the alloy until a phase composition of predetermined characteristics is obtained; subjecting the said alloy to a leaching agent adapted to effectively leach out the least one soluble metal; filtering and washing the powder; washing the powder; drying the powder; coating the powder with chemicals; and then de-agglomerating the coated powder. The present invention also discloses a cost-effective and highly pure metallic powder produced by the method defined above.
Patent IL-155124-A0 (IL)
Title: Method for producing 1 substituted 5-chloro-4 methyl pyrazoles
IPC: C07D231/20
Filed: 2001-09-28
Abstract: The present invention relates to a process for preparing 1-substituted 5-chloro-4-methylpyrazoles of the general formula I <chemistry id="CHEM-US-00001" num="000
Patent IL-162234-A0 (IL)
Title: Infrared-reflective, transparent, multi-layer plastic laminates
IPC: B32B9/00
Filed: 2002-11-27
Abstract: Laminate comprises a layer A containing a base material selected from a transparent thermoplastic plastics material (I) and a lacquer and UV absorber(s), a layer B containing (I) and colorant(s) and a layer C containing (I).  Independent claims are also included for the following: (1) Production of the laminate by coextrusion of layers A, B and C; (2) Production of the laminate by applying layer A by lacquering to a substrate comprising layers B and C.
Patent IL-162834-A0 (IL)
Title: Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
IPC: A61P19/02
Filed: 2003-01-27
Abstract: Novel amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
Patent IL-171977-A0 (IL)
Title: Cyclic sulfonamides for inhibition of gamma-secretase
IPC: C07D279/02
Filed: 2005-11-15
Abstract: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
Patent IL-172106-A0 (IL)
Title: Generating and implementing a signal protocol and interfrace for higher data rates
IPC: H04L1/00
Filed: 2005-11-22
Abstract: A method of transferring error codes in a communication system in which digital data is transferred in the form of packets having CRC values between a host device and a client device over a communication path comprising: detecting the presence of an error (6602), selecting a pre-determined error code corresponding to said error (6610), and over-writing the CRC value with said code (6612).
Patent IL-206087-A0 (IL)
Title: Indoles and their therapeutic use
Filed: 2010-05-31
Abstract: Compound of formula (I) are are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions:   
wherein X is -SO 2 - or *-SO 2 NR 3 - wherein the bond marked with an asterisk is attached to Ar 1 ; R 1  is hydrogen, fluoro, chloro, CN or CF 3 ; R 2  is hydrogen, fluoro or chloro; R 3  is hydrogen, C 1 -C 8 alkyl or C 3 -C 7 cycloalkyl; Ar 1  is phenyl or a 5- or 6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C 3 -C 7 cycloalkyl, -O(C 1 -C 4 alkyl) or C 1 -C 6 alkyl, the latter two groups being optionally substituted by one or more fluoro atoms; and Ar 2  is phenyl or 5- or 6-membered heteroaryl group selected from pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C 3 -C 7 cyCloalkyl, -O(C 1 -C 4 alkyl) or C 1 -C 6 alkyl, the latter two groups being optionally substituted by one or more fluoro atoms.
Patent RO-128803-A0 (RO)
Title: Composition for the treatment or prevention of dyslipidemias
Inventor: FULGA ION GIGEL
IPC: A61K36/899
Filed: 2012-10-12
Abstract: The invention relates to a composition for the treatment or the prevention of dyslipidemias. According to the invention, the composition is a combination between a substance of the red rice extract type which decreases the synthesis of the endogenous cholesterol, a substance which decreases the cholesterol absorption selected from sitosterol and sitostanol, a substance of the taurine type which contributes to the cholesterol degradation and a substance with effect of increasing HDL cholesterol, selected from niacin, canithine or resveratrol.
Patent AP-2000002022-A0 (AP)
Title: Operating method and device for supplementary compressed air injection engine operating with mono-energy or bi-energy in two or three power modes.
Inventor: NEGRE GUY
IPC: F04B9/135
Filed: 1999-06-02
Abstract: The invention concerns an engine method with suction-compression chamber (1)and/or expansion-exhaust chamber (4)operating by means of (2)- the three chambers being separated with a device controlling the stroke causing, over a long period of engine rotation, said piston (15)to stop at the upper dead centre which in that position separates the combustion chamber and the expansion-exhaust chamber, also comprising a high-pressure compressed air chamber (23)and additional systems for recuperating ambient thermal energy and additional heating, capable of operating in mono-energy air plus supplementary compressed air or in bi-energy, or with conventional fuel in internal or external combustion, or by injection of a dose of compressed air thereby producing three operating modes depending on the type of use. The invention is useful for all types of engine methods.
Patent CS-56286-A1 (CS)
Title: The heating element for contact resistance welding of plastics
Inventor: LICHOLETOV VALERIJ V
IPC: B29C65/30
Filed: 1986-01-24
Abstract: Holder (1) supports heater (2) with its heating elements inside casing (4) with through holes and connected to ventilation. Also inside casing, around heater, are cleaning elements (5), that can be rotated, the heaters made as rotating tubes with fixing device. Cross-sectional shape of heater is either a rectilinear polyhedron with an even no. of sides, or it can be circular. - The device is placed in the welding zone in such a way that slit-like holes of casing (4) are opposite edges of sheets being welded. Current is fed to contacts (19,20) and elements (14) heat up, raising heater temp. to welding level. Sheets are pressed against heater (2) for the reqd. time. Air is sucked from under casing through pipes (7) and manifolds (6), cold air cooling outer surface of sheets and removing breakdown prods. from the welded plastics. Abrasive elements (10) clean heaters, rotated by turbine elements (5).
Patent LU-88096-A1 (LU)
IPC: F16L27/08
Filed: 1992-04-08
Abstract: A multiple connection device for pressurized media comprises a ring (20) per media opening path, which ring (20) can be displaced parallel to the connection axis (12) and relative to the respective connecting part (2, 2') with respect to an elastic element (26) which acts axially in the connection direction of the respective connection part (2, 2'), The ring (20) furthermore has a first pressure surface (24) for the pressurized medium, whose nett projection area parallel to the connection axis is subjected to the media pressure in the connection direction of the respective connecting part (2, 2'). <IMAGE>
Patent MA-20210-A1 (MA)
IPC: C07C69/738
Filed: 1984-08-23
Abstract: Compounds of the formula (I):    <IMAGE>  (I)  in which R1 represents alkyl containing from 1 to 18 carbon atoms, R2 represents hydrogen or alkyl containing from 1 to 8 carbon atoms and R represents hydrogen or alkyl containing from 1 to 8 carbon atoms, as well as the alkali metal, alkaline-earth metal or amine salts thereof, in which R represents hydrogen. Also, method of preparing same, compositions containing same and therapeutic treatment therewith.
Patent MA-38490-A1 (MA)
Title: Flacon de conditionnement de liquide
Inventor: MERCIER FABRICE
IPC: B65D83/38
Filed: 2015-10-13
Abstract: L'invention concerne un flacon de conditionnement de liquide comportant un réservoir (2) sur lequel est montée une tête de distribution (4), laquelle comporte une portion mobile (16) axialement d'un système de pompe de prélèvement du liquide et un embout de distribution (12) solidaire en déplacement de la portion mobile et par lequel le liquide est délivré. Selon l'invention, le flacon comporte une coiffe (6) formée d'un manchon de recouvrement (20) de ladite portion mobile pour l'actionnement de la pompe et une partie amovible (22) de recouvrement du flacon, ladite partie amovible étant retenue audit manchon par un dispositif de retenue (24) fracturable lors de la première utilisation du flacon.
Patent MA-39131-A1 (MA)
Title: Plateforme ultrasons miniaturisée portative
Inventor: BENNANI RACHID
IPC: G01S15/89
Filed: 2016-06-21
Abstract: La présente innovation concerne tout objet pouvant être reconnu par un simple et unique système portatif de détection non destructive utilisant la technologie ultrason dans une large gamme de fréquence allant de quelques khz jusqu'au 100 mhz, en particulier la présence et ou la détection de: bactérie dans le lait uht, maturité des oranges, niveau de liquide et fissures cachées dans un métal, lié au processus de diagnostic, de mesure et de contrôle rapide et précis en temps réel, avec et sans contact manuel et sans avoir besoin de se déplacer à un laboratoire d'analyse.
Patent MA-39363-A1 (MA)
Title: Procede et appareil pour le stockage de donnees utilisees pour le suivi d'articles fabriques.
Inventor: CHANEZ PATRICK
IPC: G06Q10/00
Filed: 2013-12-16
Abstract: L'invention concerne un procédé pour la génération et le stockage de données relatives à des articles fabriqués au sein d'un lot d'articles fabriqué, permettant de réduire les besoins en stockage de données. Le procédé peut comprendre les étapes consistant à : sur une ligne de production, générer un identificateur unique pour chaque article, l'identificateur unique comprenant des informations de production et une valeur de compteur d'un compteur incrémental; sur une ligne de production, associer chaque article avec l'identificateur unique correspondant ou avec une version chiffrée de l'identificateur unique; lire au moins certains des identificateurs uniques associés aux articles du lot d'articles pour produire une liste d'identificateurs lus, au moins certaines valeurs de compteur du compteur incrémental étant absentes de la liste des identificateurs lus; générer une pluralité de plages d'identificateurs lus, chaque plage comprenant un certain nombre d'identificateurs lus possédant des informations de production communes et des valeurs de compteur séquentielles; et stocker la pluralité de plages d'identificateurs lus ayant des informations de production communes en tant qu'enregistrement de données unique dans une base de données électronique, l'enregistrement de données unique comprenant les informations de production et une indication de chacune des plages de valeurs de compteur séquentielles.
Patent UY-23375-A1 (UY)
Title: Bola sonora
IPC: G08B7/06
Filed: 1992-02-13
Abstract: Se describe una bola sonora que funciona como parlante acústico, constituida por un elemento esférico hueco de material flexible con una película magnética, suspendido de un punto a una base de fijación, esfera la cual aloja en su interior una bobina montada sobre un núcleo central de material magnético de baja histéresis (elemento fijo), capaz de hacer mover por acción magnética la esfera exterior la cual define un espacio hermético y se encuentra bajo presión constante dada por un elemento gaseoso en su interior, produciéndose un movimiento de contracción y de expansión según una dirección colineal con el eje de la bobina. Ver figura 1.
Patent UY-26782-A1 (UY)
Title: Derivados del benzotiazol
Inventor: ALANINE ALEXANDER
IPC: C07D417/04
Filed: 2001-06-20
Abstract: La presente invención se refiere a compuestos de la fórmula general I. Y a las sales farmacéuticamente aceptables para el tratamiento de enfermedades relacionadas con el receptor de adenosina.
Patent UY-28162-A1 (UY)
Title: Un procedimiento para la preparación de mesilatos de derivados de piperazina y dichos mesilatos
Inventor: AAR MARCEL P M VAN
Filed: 2004-01-07
Abstract: La invención e refiere a un procedimiento para la preparación de los mesilatos de un grupo de derivados de piperazina de modo económico, con elevado rendimiento y elevada pureza, y a dichos mesilatos. De acuerdo con el procedimiento de la invención, la síntesis del anillo de piperazina y la formación del mesilato son combinados en una sola etapa de reacción. La invención se refiere a mesilatos de compuestos de fórmula en donde X es un grupo bicíclico fenil-heterocíclico, e Y es metilo, etilo (opcionalmente sustituido con fluor), cicloalquil (C3 - 7) metilo, bencilo o m-fenilbencilo.
Patent UY-28442-A1 (UY)
Title: Compuestos de indazol 3,5-disustituidos, composiciones farmaceuticas y métodos para intervenir en o inhibir la proliferacion celular
Inventor: KEPHART SUSAN ELIZABETH
IPC: A61P35/00
Filed: 2004-07-27
Abstract: Compuestos de indazol 3,5-disustiuidos que modulan y/o inhiben la proliferación celular tal como la actividad de las proteínas cinasa. Estos compuestos y composiciones farmacéuticas que los contiene son capaces de intervenir en enfermedades dependientes de la CDK para modular y/o inhibir laq prolifación celular no deseada. Uso terapéutico o profiláctico de composiciones farmacéuticas que contienen tales compuestos y a métodos para tratar el cáncer así como otras condiciones patológicas asociadas con angiogenesis y/o prolifaración celular, no deseada, tales como: retinopatia diabética, glaucoma neovascular, artritis reumatoide y soriasis, por administración de cantidades eficaces de tales compuestos.
Patent ES-160451-A1 (ES)
Title: PROCEDIMIENTO PARA EFECTUAR EL CAMBIO DEL FRiO EN LOS APARATOS DE FRACCIONAMIENTO DEL AIRE Y DE LOS GASES POR MEDIO DE oRGANOS GIRATORIOS, Y APARATO PARA REALIZARLO
IPC: F25J3/00
Filed: 1943-02-24
Abstract: Procedimiento para efectuar el cambio del frio entre dos o varios flúidos caracterizado en que los flúidos son obligatorios a atravesar de una manera contínua y en la dirección paralela al eje los sectores de un cilíndro giratorio rellenos de cuerpo sólidos de un calor específico elevado de suerte que por efecto de la rotación los mismos sectores son sucesivamente atravesados primeramente por uno de los flúidos y después por el otro o por los otros.
Patent ES-178478-A1 (ES)
Title: UN PROCEDIMIENTO DE OBTENCIoN DE NUEVOS COMPUESTOS PIRIMIDiNICOS
Filed: 1947-06-16
Abstract: Procedimiento para la obtención de nuevos compuestos pirimidínicos caracterizándose porque formando el ciclo pirimidínico se hacen reaccionar sobre amidinas de ácidos carboxilicos alifáticos con 4 - 7 átomos de carbono derivados funcionales de ácidos malónicos cuyo grupo metilénico está constituido por dos radicales de hidrocarburos O bien poniendo en reacción amidas del ácido melónico de correspondiente C-sustitución con halogenuros o ésteres de ácidos carboxílicos alifáticos que contienen 4-7 átomos de carbono o tratando amidas de dichos ácidos carboxílicos alifáticos con halogenuros o ésteres de ácidos malónicos de correspondiente C-sustitución.
Patent ES-179507-A1 (ES)
Title: MEJORAS EN SISTEMAS TELEFoNICOS AUTOMáTICOS Y SIMILARES
Filed: 1947-08-28
Abstract: En un sistema telefónico automático y similar, medios en la oficina de origen y medios en la oficina de destino, para efectuar el enlace de los busca-líneas de salida con un línea disponible sin que se efectúe llamada alguna,medios en la oficina de destino, par establecer la conexión entre un circuito de línea entrante y los de gobierno o registradores y medios en la oficina de origen para dirigir las llamadas solamente a las cadena de conexión así pre-establecidas.
Patent ES-179531-A1 (ES)
Title: Unos perfeccionamientos en los tacos para telares
Filed: 1947-08-12
Abstract: Unos perfeccionamientos en los tacos para telares caracterizados por el hecho de limitar el uso del cuero o caucho comprimido a un solo y pequeño núcleo cilíndrico o prismático que actuará de percutor para accionar a la lanzadera; quedando este núcleo envuelto amordazado y fijado al resto del taco que se fabricará al efecto con chapa metálica estampada formándose así el estribo el puente de enlace con la correa de propulsión y los elementos de apoyo sobre la guía dispuesta en el telar para el taco. Asimismo el hecho de que se hagan coincidir en un mismo eje el de la guía y el del puente de enlace.
Patent ES-181087-A1 (ES)
Title: Un generador de impulsos
Filed: 1947-12-23
Abstract: Un generador de impulso caracterizado por la combinación de un oscilador gobernado a cristal y un oscilador bloqueado.
Patent ES-181222-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA DESINFECCIoN DE SEMILLAS
Filed: 1947-12-29
Abstract: Procedimiento para conservar cereales empleando un líquido agente germicida que contiene en solución o dispersión combinaciones orgánicas de mercurio, caracterizado porque como portador de la sustancia germicida se emplea agua, un líquido orgánico junto con sustancias disueltas, emulaciones o dispersas en el mismo, o una y otro, que al escaparse líquido de los distintos granos de semilla forma una delgada cubierta o película permanente y la sustancia germicida se distribuye uniformemente en los granos y se adhiere a ellos, de manera que el líquido conservador se emplea en una cantidad que no rebasa esencialmente los 6g. por kg., y en las clases de cereales corrientes con preferencia es a lo sumo de 2 a 3 g. por kg.