baber/WOPTO huggingface dataset:
Patent WO-2022261716-A1 (WO)
Title: Aqueous formulations for preservation of extracellular vesicles
Inventor: JAMES PATRICK F
IPC: A61K47/02
Filed: 2022-06-16
Abstract: The present invention relates to aqueous formulations comprising a polyol, a sugar or combination thereof, a non-ionic surfactant, a salt and a buffering agent. The aqueous formulation of the present invention further comprises extracellular vesicles (EVs). The present invention also relates to using said formulations for the preservation, in particular through freezing, and/or the administration of the EVs. Particular exemplified embodiments comprise 5% w/v sucrose or 12.5% w/v trehalose, 20 mM histidine, 150 mM NaCl and 0.01-0.2% w/v Polysorbate 20 with a pH of 6.0. These formulations can further comprise Plexaris or Cevaris which are EVs or exosomes, respectively.
Patent WO-2023015357-A1 (WO)
Title: A marina
Inventor: FRASER MARK ANDREW
IPC: E02B3/06
Filed: 2022-08-12
Abstract: The present invention relates to a marina. The marina includes a spine. Vessel berths extend along the spine and are configured to enable vessels to berth obliquely to the spine. Advantageously, the vessels may be berthed obliquely to the spine, avoiding tight 90° turns, for safer berthing of the vessels. The berths may be reconfigured to accommodate vessels of different size, on a needs basis, for improved berthing efficiency.
Patent AU-2022200067-A1 (AU)
Title: Improved productivity and bioproduct formation in phototropin knock/out mutants in microalgae
Inventor: NEGI SANGEETA
IPC: C12P7/64
Filed: 2022-01-06
Abstract: Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological 
processes in plants and algae. In higher plants these processes include phototropism, chloroplast 
movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a 
vital role in progression of the sexual life cycle and in the control of the eye spot size and light 
sensitivity. Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, 
carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out 
(PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown 
cultures (500 pmol photons m-2 S-1). Our results indicate the up-regulation of genes involved in 
photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control 
genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the 
cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled 
electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5
bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), 
Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) 
were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in 
starch and lipid synthesis. In addition, transmission electron micrographs show increased 
accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the 
higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in 
the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation 
compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a 
pond environment. In conclusion, our studies suggest that phototropin may be a master gene 
regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in 
wild type strains.
Patent AU-2022200647-A1 (AU)
Title: Methods of making and using embryonic mesenchymal progenitor cells
Inventor: GSCHWENG ERIC
IPC: C12N5/0735
Filed: 2022-02-01
Abstract: The disclosure provides a method of generating non-clustered stem cells. Cluster disruption 
prior to mesoderm differentiation increases yield and efficiency in hEMP and T cell 
differentiation. Thus, this method allows the development of improved methods of hEMP 
and T cell differentiation.
Patent AU-2022201868-A1 (AU)
Title: Fluorocarbon-based liquid recirculating cooling apparatus and method for recirculating cooling using fluorocarbon-based liquid
Inventor: MAI KAICHANG
IPC: H05K7/20
Filed: 2022-03-17
Abstract: A fluorocarbon-based liquid recirculating cooling apparatus is disclosed herein. The apparatus 
comprises a cooling enclosure, a heat exchanger and a pump. The cooling enclosure 
comprises an enclosure body having a side wall; at least one side dispensing tube disposed in 
the enclosure body near the side wall, the at least one side dispensing tubes comprising a 
plurality of openings configured to allow fluorocarbon-based liquid flowing through the at 
least one side dispensing tube to be dispensed downwardly at an angle toward the side wall; 
and at least one discharge tube for allowing the fluorocarbon-based liquid to be transferred to 
the heat exchanger for cooling. The heat exchanger is configured to cool the fluorocarbon
based liquid from the at least one discharge tube. The pump is configured to deliver the 
cooled fluorocarbon-based liquid from the heat exchanger to the at least one side dispensing 
tube.
3/3 
F 
1112 
122 
Ila 
11 
13 
Fig. 5
Patent AU-2022202821-A1 (AU)
Title: Medical device with anti-rotation push tab
Inventor: BORNHOFT STEPHEN
IPC: A61M25/02
Filed: 2022-04-28
Abstract: A medical device (100), comprising a hub (102) or housing (118) having a push tab (112) 
including a main portion extending radially from an upper surface of the hub (102) or housing 
(118), and at least one anti-rotation feature (114, 116) for resisting rotation of the hub (102) or 
housing (118). A cannula (103) is directly or indirectly connected to the hub (102) or housing 
(118). The medical device (100) maybe a catheter, the cannula (103) maybe a catheter tube, 
and the hub (102) or housing (118) may be a catheter hub or an introducer needle tip shield of 
the catheter (100).
Patent AU-2022211362-A1 (AU)
Title: Surgical gas delivery system and method for gas sealed insufflation and recirculation using proportional valves
Inventor: KOLTZ MICHAEL
IPC: A61M13/00
Filed: 2022-01-19
Abstract: A surgical gas delivery system is disclosed for gas sealed insufflation and recirculation, which includes a gaseous sealing manifold for communicating with a gas sealed access port, an insufflation manifold for communicating with the gas sealed access port and with a valve sealed access port, a compressor for recirculating gas through the gas sealed access port by way of the gaseous sealing manifold, a first outlet line valve associated with the insufflation manifold for controlling a flow of insufflation gas to the gas sealed access port, a second outlet line valve associated with the insufflation manifold for controlling a flow of insufflation gas to the valve sealed access port, and a proportional valve associated the insufflation manifold and located upstream from the first and second outlet line valves for dynamically controlling the flow of insufflation gas to the first and second outlet line valves.
Patent AU-2022215196-A1 (AU)
Title: Predicting T cell epitopes useful for vaccination
Inventor: SAHIN UGUR
IPC: G01N33/68
Filed: 2022-08-10
Abstract: The present invention relates to methods for predicting T cell epitopes useful for 
vaccination. In particular, the present invention relates to methods for predicting whether 
modifications in peptides or polypeptides such as tumor-associated neoantigens are 
immunogenic and, in particular, useful for vaccination, or for predicting which of such 
modifications are most immunogenic and, in particular, most useful for vaccination. The 
methods of the invention may be used, in particular, for the provision of vaccines which 
are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
Patent AU-2022216913-A1 (AU)
Title: Reduction of water/energy waste in a water provision system
Inventor: KONOWALCZYK PETER
IPC: F24D19/10
Filed: 2022-02-07
Abstract: A heater arrangement system for a water provision system for controlling a water supply provided to a water outlet, the water outlet being arranged to provide heated water to a user, the heater arrangement system comprising: a water heating device disposed remotely from the water outlet; and a control unit communicatively coupled to the water heating device, the control unit being configured to a) set a timer to begin counting from an initial time value, upon detection that the water outlet has been opened, and b) initiate a warning if an elapsed time of the timer has passed a first threshold time value.
Patent AU-2022217025-A1 (AU)
Title: Gas grill with burner-bypassable temperature control
Inventor: HOU JAMES
IPC: A47J37/07
Filed: 2022-02-02
Abstract: A gas-fired cooking grill and a gas valve assembly for a gas-fired cooking grill are provided. The grill includes a cooking chamber, a plurality of gas burners for heating the cooking chamber, a plurality of first valves each to control flow of a combustible gas to a respective one of the gas burners, a gas intake to receive the combustible gas from a combustible gas source, and a second valve comprising a thermostatic valve portion, the second valve disposed intermediate the gas intake and plurality of first valves and in fluid communication therewith, the second valve configured to receive input from a user for selection between a first cooking mode and a second cooking mode, the second valve routing the combustible gas from the gas intake to the plurality of first valves in the first cooking mode and routing the combustible gas from the gas intake to the thermostatic valve portion in the second cooking mode, the thermostatic valve portion selectively routing the combustible gas to a subset of the gas burners based on a comparison of a desired temperature and an actual temperature of the cooking chamber.
Patent AU-2022222303-A1 (AU)
Title: Emulsion composition and uses thereof in the prevention and/or treatment of skin damage caused by radiation
Inventor: WINCKLE GARETH
IPC: A61K9/00
Filed: 2022-02-18
Abstract: The invention relates to a water-based composition in a form suitable for topical administration, comprising a vasoconstrictor. The invention is characterized in that it is in the form of an emulsion comprising liquid crystals and in that the composition comprises a vasoconstrictor chosen from brimonidine or salts thereof, in a solvent-based phase comprising: - polyethylene glycol in combination with propylene glycol; - a hydrophilic film-forming agent chosen from a polyvinylpyrrolidone/vinyl acetate copolymer, and polyvinylpyrrolidone in a non-crosslinked, crosslinked or acetate form, taken alone or in combination; - glycerin; - an emulsifier chosen from the combination PEG-75 stearate and glyceryl monostearate and the combination polyoxyethylene-20 sorbitan monostearate (polysorbate-60) and cetostearyl alcohol; - an oleic acid or an oleyl alcohol, preferentially an oleyl alcohol; - and an oily phase suitable for obtaining an emulsion comprising liquid crystals.
Patent AU-2022242558-A1 (AU)
Title: Catheter valve for controlling the fluid flow of a medium
Inventor: SCHWARZ WERNER
IPC: A61M25/00
Filed: 2022-03-16
Abstract: The invention relates to a catheter valve for controlling the fluid flow of a medium, in particular a self-closing catheter valve, wherein a main body comprises: - an inlet and an outlet, - a flexible tube, - as a cover, a slider which is movable in the longitudinal direction, and - at the inlet of the catheter valve, a stepped barbed part for connecting a supply line; and, in the interior of the main body that comprises two laterally opposite vertical chambers, the catheter valve has two contradirectional downward inclines on the longitudinally movable slider. The problem addressed by the invention is that of developing a catheter valve: 1. which is ergonomically effectively shaped, so that the patient can become accustomed to it even if they are bedridden for a long period of time; 2. since care costs are particularly significant for long-term patients, the catheter valve must be extremely economical; 3. since geriatric patients often have reduced motor function, the catheter valve must be operated extremely simply and using one hand; 4. since usage is often long-term, it must be possible to flush through and sterilise the entire valve without difficult disassembly, 5. unintended detachment of the catheter from the catheter valve is prevented, which avoids the risk of infection. This is achieved according to the invention in that the main body that comprises two contradirectional downward inclines comprises two contradirectional inclined chambers for actuating and guiding two vertically movable magnets, which are arranged on two opposite sides of the valve hose and selectively close or open the passage of said valve hose, wherein an adapter can be inserted and fastened at the outlet of the catheter valve and (in addition to the longitudinally movable slider) results in a permanent open position of the catheter valve.
Patent AU-2022254939-A1 (AU)
Title: Automatic classification of excavation materials
Inventor: ARTAN UNAL
IPC: G01N37/00
Filed: 2022-04-06
Abstract: Methods and apparatus for automatic material classification use proprioceptive sensing data acquired from equipment interacting with the material. Embodiments enable automatic material identification with low operational complexity and computational overhead. Automatic material classification may be used to improve autonomous operation of robotic excavators, as well as provide useful knowledge about excavation materials (e.g., rock size distribution) in fields such as civil and mining operations, military operations, aggregate material handling and processing, and space exploration and development to improve downstream processing and operations.
Patent AU-2022271452-A1 (AU)
Title: Dishwasher
Inventor: KIM SUNG SIK
IPC: A47L15/48
Filed: 2022-11-17
Abstract: The present disclosure relates to a dishwasher in which dry air spraying from an airflow 
5 guide is evenly distributed into a tub not to concentrate heat energy of the dry air on a specific 
portion, thereby reducing a dry period for wash targets and improving drying efficiency, and 
effectively preventing deterioration in drying efficiency, which is caused by a change in the 
direction of a discharge opening when misassembly occurs.
Patent AU-2022277418-A1 (AU)
Title: Viral vector production systems, engineered cells for viral vector production, and methods of use thereof
Inventor: GAM JEREMY J
IPC: C12N15/11
Filed: 2022-05-17
Abstract: Described herein are viral vector production systems and engineered cells for viral vector production. Also described herein are methods of using the engineered cells to produce viral vectors.
Patent AU-2022283628-A1 (AU)
Title: Cryoprobe with stiffening element
Inventor: TRUMER DROR
IPC: A61B18/02
Filed: 2022-12-05
Abstract: CRYOPROBE WITH STIFFENING ELEMENT 
Abstract 
Aspects of the present invention provide miniaturized cryoprobes having shaft diameters up to 
2 mm and including a stiffening element that may act as a grip for manipulation of the cryoprobe.  
Various aspects of the present disclosure are generally directed towards apparatuses, systems, and 
methods that may include a cryoprobe: In certain instances, the cryoprobe may include an elongate 
shaft and an operating head having an expansion chamber. The elongate shaft may include a first 
passageway configured to provide high pressure gas to the expansion chamber, a second passageway 
for evacuating gas from the expansion chamber, and a vacuum chamber coaxially arranged around the 
first passageway and the second passageway.
Patent AU-2022287033-A1 (AU)
Title: Pyridopyrimidine derivatives useful as wee1 kinase inhibitors
Inventor: GILAD OREN
IPC: C07D471/04
Filed: 2022-06-03
Abstract: The disclosure provides compounds, or pharmaceutically acceptable salts thereof, and methods of using these compounds to inhibit Weel kinase and treat, for example, cancer in a subject. Claimed compounds include compounds (I).
Patent AU-2022287225-A1 (AU)
Title: Piperidine urea derivatives for use as inotropic agents
Inventor: LUND LARS
IPC: A61K31/4468
Filed: 2022-06-02
Abstract: The invention concerns the use of compounds represented by formula (I) as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1- (2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.
Patent AU-2022291391-A1 (AU)
Title: Plant-based cream cheese product and method of making a plant-based cream cheese product
Inventor: GORIS MADELINE ERICKSON
IPC: A23C20/00
Filed: 2022-06-10
Abstract: A plant-based cheese product, particularly cream cheese type products, is provided herein. The plant-based cheese products are in the form of an emulsion comprising a plant-based protein, a stabilizer, a starch-based thickening agent, and a fat component. The plant-based cheese has a spreadable texture and opaque appearance at both refrigerated and elevated temperatures.
Patent AU-2022354495-A1 (AU)
Title: Torrefaction unit and method
Inventor: EURLINGS JOHANNES THEODORUS GERARDUS MARIE
IPC: C10B47/36
Filed: 2022-09-08
Abstract: The torrefaction unit (1) comprises at least one multiple hearth furnace (2) which is heated by a heat transfer fluid (16) comprising hot water taken form a water space (21) of a steam drum (11). The heat transfer fluid (16) is guided through a water circuit (20) to a heating system (19) of the at least one multiple hearth furnace (2). This means the multiple hearth furnace (2) is heated to a torrefaction temperature indirectly by the use of hot water as heat transfer fluid (16). This is environmentally advantageous. The torrefaction gas (3) created by the torrefaction of material comprising biomass such as municipal solid waste is preferably partially oxidized in a partial oxidation reactor (23) for creating syngas. Preferably, a part of the thermal energy of the syngas is used in an evaporator (9) and/or a superheaterl (3) to heat water and/or steam and/or to evaporate water. The evaporated water is preferably guided to a steam space (22) of the steam drum (11) and can, thus, be used to heat the heat transfer fluid (16). The partial oxidation reactor (23) and the temperature of the heat transfer fluid (16) can be controlled independently allowing to one single partial oxidation reactor (23) for at least two multiple hearth furnaces (2).
Patent WO-2023225723-A1 (WO)
Inventor: PUNYADEERA CHAMINDIE
IPC: G01N33/68
Filed: 2023-05-29
Abstract: The present disclosure relates generally to biomarkers of fibrosis. More particularly, the present disclosure relates to salivary biomarkers and their use in methods, apparatuses, compositions and kits for determining an indicator that is useful for assessing a likelihood of a presence, absence or degree of liver fibrosis in a human subject. In particular embodiments, the disclosed methods, apparatuses, compositions and kits are used to determine an indicator for assessing a likelihood of a presence, absence or development of liver cirrhosis in a subject.
Patent AU-2023202659-A1 (AU)
Title: Cell culture process for making a glycoprotein
Inventor: CHEN JOHN
IPC: C07K14/415
Filed: 2023-05-01
Abstract: The instant application provides a method for screening batches of soy hydrolysate for a desired 
amount of a component thereof, such as ornithine or putrescine, and selecting only those batches of 
soy hydrolysate that have a desired amount of such component. The present disclosure also sets 
forth methods for culturing cells in media supplemented with selected batches of soy to produce 
more consistent, high quality lots of a protein of interest. Further, the present disclosure provides a 
plurality of protein preparations that have each been produced by culturing cells in media 
supplemented with separate batches of soy hydrolysate containing a desired amount of ornithine or 
putrescine, whereby each batch of protein produced exhibits improved quality of the protein of 
interest or amount of quality protein produced.
Patent AU-2023226775-A1 (AU)
Title: Adjustable pre-sutured allograft construct
Inventor: BLEDSOE RUTH
IPC: A61F2/08
Filed: 2023-09-08
Abstract: A pre-sutured allograft construct and method of manufacture for repairing, 
replacing, reconstructing, or augmenting a hip or shoulder labrum may include 
a folded tissue portion extending from a first end to a second end and forming top, 
middle, and bottom folds. A stitched pattern secures the folded tissue portion into 
a graft roll having an overall length extending from a first adjustable region, 
through a central region, and through a second adjustable region. A continuous 
series of whip stitches extends from the first adjustable region, through the central 
region, and through the second adjustable region. A series of triple circumferential 
stitches overlays the whip stitches in the first and the second adjustable regions, 
while a series of circumferential stitches alternates with the whip stitches in the 
central region. The construct is pre-manufactured as an allograft product, but is 
adjustable during the surgical procedure within the body. Other embodiments are 
also disclosed.
Patent AU-2023278061-A1 (AU)
Title: Method for preparing benzofuran derivative
Inventor: LU WEIDONG
IPC: C07D405/14
Filed: 2023-12-07
Abstract: Disclosed is a method for preparing a benzofuran derivative. In particular, 
provided is a method for preparing a benzofuran derivative, wherein according to the 
method provided, reaction steps required to synthesize the benzofuran substance in the 
prior art can be effectively shortened.
Patent WO-2006056032-A1 (WO)
Title: Procedes et dispositifs de lutte contre les nuisibles
Inventor: GRIGOROV GRIGOR RANGELOV
IPC: A01M23/38
Filed: 2005-11-25
Abstract: Ces procédés et dispositifs, qui conviennent à des applications notamment domestiques, industrielles, sanitaires, agricoles et sylvicoles, sont destinés à la neutralisation et à l'extermination de nuisibles. Ils sont complexes, universels, écologiques et d'une efficacité et d'une productivité accrues. Le dispositif représenté à la figure 1 est constitué d'une plate-forme conique inclinée (1) qui associée à un couvercle conique supérieur (19) attaché à la plate-forme par des connexions télescopiques (13) traversant une plate-forme transitoire circulaire (14) forment un couloir intégré (15) le long du pourtour du dispositif à l'extrémité supérieure de la plate-forme conique inclinée (1) par la plate-forme circulaire (14) est lié l'extrémité la plus large d'une cheminée (2), l'extrémité inférieure (la plus étroite) est disposé centralement au-dessus d'un récipient mobile (6), là où le détournement (7) est placé, là où un chariot électrique zéro (3) et un chariot électrique.phase (4) sont attachés l'un après l'autre sur la surface intérieure de la cheminée (2).