Patent SG-11201900026T-A (SG)
Title: Antibodies against tim3 and uses thereof
Inventor: SCHEBYE XIAO MIN
IPC: C07K16/28
Filed: 2017-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111 01110111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/013818 A2 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, C07K 16/28 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2017/041946 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 13 July 2017 (13.07.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/362,541 14 July 2016 (14.07.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/459,499 15 February 2017 (15.02.2017) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, [US/US]; Rt. 206 & Province Line Road, Princeton, New KM, ML, MR, NE, SN, TD, TG). Jersey 08543 (US). (72) Inventors: SCHEBYE, Xiao Min; 700 Bay Road, Red- Declarations under Rule 4.17: wood City, California 94063 (US). SELBY, Mark J.; — of inventorship (Rule 4.17(iv)) — 700 Bay Road, Redwood City, California 94063 (US). Published: HAN, Michelle Minhua; 700 Bay Road, Redwood City, — without international search report and to be republished = California 94063 (US). BEE, Christine; 700 Bay Road, upon receipt of that report (Rule 48.2(g)) Redwood City, California 94063 (US). DENG, Andy X .; _ with sequence listing part of description (Rule 5.2(a)) 700 Bay Road, Redwood City, California 94063 (US). _ CHUNTHARAPAI, Anan; 700 Bay Road, Redwood City, California 94063 (US). DEVAUX, Brigitte; 320 Duluth = Circle, Palo Alto, California 94306 (US). LI, Huiming; 91 Grove Street, Lexington, Massachusetts 02420 (US). —_ SHEPPARD, Paul 0.; 13532 278th Drive NE, Granite = Falls, Washington 98252 (US). KORMAN, Alan J.; 700 Bay Road, Redwood City, California 94063 (US). AR- = - DOUREL, Daniel F.; 19010 201st Avenue NE, Wood- inville, Washington 98077 (US). DEYANOVA, Ekateri- - na; Rt. 206 & Province Line Road, Princeton, New Jer- _ = sey 08543 (US). HUANG, Richard; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). CHEN, Guodong; Rt. 206 & Province Line Road, Princeton, New = Jersey 08543 (US). KUHNE, Michelle; 700 Bay Road, Redwood City, California 94063 (US). TRUONG, Hong- = An; 700 Bay Road, Redwood City, California 94063 (US). = Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & (74) = — Fox P.L.L.C., 1100 New York Avenue, NW, Washington, = District of Columbia 20005 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (81) — N GC Il X ) (54) Title: ANTIBODIES AGAINST TIM3 AND USES THEREOF en 1-1 (57) : Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin- 0 ----. domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic GC Il applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, © polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors com- el prising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. O