baber/WOPTO huggingface dataset:
Patent DE-69629684-D1 (DE)
Inventor: ISRAEL I
IPC: C12N15/09
Filed: 1996-06-05
Granted: 2003-10-02
Abstract: Simple, rapid, high-throughput functional bioassays for identifying agents that act as either agonists or antagonists of G-protein coupled receptors (GPCRs) are disclosed. In the methods of the invention, a test composition is contacted with an indicator cell expressing a GPCR and at least one parameter of cellular metabolism of the indicator cells is measured to identify a test compound(s) in the test composition as a receptor agonist or antagonist. The assays can be used to screen libraries of test compounds to identify therapeutically useful agonists or antagonists of GPCRs involved in disease conditions. The assays can also be used to identify ligands of "orphan" GPCRs whose natural ligands are unknown. Methods of generating indicator cells expressing GPCRs, and isolated populations of such indicator cells, are also disclosed.
Patent DE-69705844-D1 (DE)
Inventor: CLAWSON G
IPC: H01M8/06
Filed: 1997-08-25
Granted: 2001-08-30
Abstract: An apparatus and a method are disclosed for converting hydrocarbon fuel or an alcohol into hydrogen gas and carbon dioxide. The apparatus includes a first vessel having a partial oxidation reaction zone and a separate steam reforming reaction zone that is distinct from the partial oxidation reaction zone. The first vessel has a first vessel inlet at the partial oxidation reaction zone and a first vessel outlet at the steam reforming zone. The reformer also includes a helical tube extending about the first vessel. The helical tube has a first end connected to an oxygen-containing source and a second end connected to the first vessel at the partial oxidation reaction zone. Oxygen gas from an oxygen-containing source can be directed through the helical tube to the first vessel. A second vessel having a second vessel inlet and second vessel outlet is annularly disposed about the first vessel. The helical tube is disposed between the first vessel and the second vessel and gases from the first vessel can be directed through second vessel. <IMAGE>
Patent DE-69709742-D1 (DE)
Inventor: BEHLING R
IPC: C07C229/34
Filed: 1997-07-10
Granted: 2002-02-21
Abstract: The invention herein is directed to a process for the preparation of ethyl 3S-amino-4-pentynoate which involves treating 3-(trimethylsilyl)-2-propynal with L-phenylglycinol in toluene to produce  alpha S-[[3-(trimethylsilyl)-2-propynylidene amino]benzenethanol; reacting  alpha S-[[3-(trimethylsilyl)-2-propynylidene]amino]benzenethanol with BrZnCH2CO2t-Bu in THF/NMP to produce 1,1-dimethylethyl 3S-[(2-hydroxy-1S-phenylethyl)amino]-5-(trimethylsilyl)-4-pentynoate; reacting the 1,1-dimethylethyl 3S-[(2-hydroxy-1S-phenylethyl)amino]-5-(trimethylsilyl)-4-pentynoate with sodium periodate to form 1,1-dimethylethyl 3S-[(phenylmethylene)amino]-5-(trimethylsilyl)-4-pentynoate; hydrolyzing 1,1-dimethylethyl 3S-[(phenylmethylene)amino]-5-(trimethylsilyl)-4-pentynoate to produce 1,1-dimethylethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate; transesterifying 1,1-dimethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate and desilylating to produce ethyl 3S-amino-4-pentynoate.
Patent DE-69710224-D1 (DE)
Inventor: THE MOUNT SINAI SCHOOL OF MEDI
IPC: C12N5/02
Filed: 1997-11-19
Granted: 2002-03-14
Abstract: The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against beta-amyloid induced cell death. Without being bound to any particular theory, it appears that nimesulide inhibits a non-inflammatory mechanism of neurodegeneration.
Patent DE-69713621-D1 (DE)
Inventor: HELANDER OSSI
IPC: B29C53/58
Filed: 1997-05-20
Granted: 2002-08-01
Abstract: The invention relates to a method for manufacturing a pipe fitting, said method comprising manufacturing a preform (1) of plastic, and forming an additional layer (3) on top of it. According to the invention, the additional layer (3) is formed by winding a film on the preform until the desired total wall thickness is reached, and the film is wound using at the same time pretensioning in a desired direction. The invention further relates to a pipe fitting manufactured by this method.
Patent DE-69716471-D1 (DE)
Inventor: SHERMAN C
IPC: A61B17/58
Filed: 1997-11-05
Granted: 2002-11-21
Abstract: In one embodiment, a spinal fixation assembly includes an elongated member, such as a spinal rod, configured for placement adjacent the spine and a bone engaging fastener, such as a bone screw having a lower portion configured for engaging a vertebra and a head that is at least partially spherical. The assembly further includes a receiver member defining a bore therethrough from a top end to a bottom end, a recess for receiving the head of the bone screwing fastener therein, and a lower opening at said bottom end of the receiver member through which the bone screw extends. The recess is configured to at permit pivoting of the bone screw within the receiver member until the head is fixed within the recess. The receiver member also includes a channel communicating with the bore and having an upper opening at the top end of the receiver member for insertion of the spinal rod into the channel. In one embodiment, two compression members are provided, each being formed of a temperature responsive material and having a first configuration at a first temperature and a different second configuration at a different second temperature in which the compression member contracts about a portion of the receiver member to thereby compress the receiver member about both the head of the bone screw within the recess and the spinal rod within the channel.
Patent DE-69722657-D1 (DE)
Inventor: WESTLAND A
IPC: D21H11/20
Filed: 1997-12-11
Granted: 2003-07-10
Abstract: Crosslinked cellulose fibers having free pendant carboxylic acid groups are disclosed. The fibers include a polycarboxylic acid covalently coupled to the fibers, and are crosslinked with a crosslinking agent having a cure temperature lower than the cure temperature of the polycarboxylic acid. Methods for producing the fibers and for producing a fibrous sheet incorporating the fibers are also disclosed.
Patent DE-69723718-D1 (DE)
Inventor: JAMES W
IPC: F25D11/00
Filed: 1997-11-04
Granted: 2003-08-28
Abstract: A low-cost and thermodynamically efficient implementation of a two-stage refrigeration system applied to a retail refrigerator. The invention includes a simple and easily manufactured thermally efficient and low-cost evaporation unit. The invention further includes a thermal energy storage module and an energy efficient control protocol to maintain steady temperatures in the fresh and frozen food sections, to permit energy efficient defrosting of the heat exchange surfaces in the freezer section, and minimize losses associated with condensing unit on-and-off cycling.
Patent DE-69725023-D1 (DE)
Inventor: SHI YIAN
IPC: C07D303/40
Filed: 1997-10-08
Granted: 2003-10-23
Abstract: A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.
Patent DE-69736486-D1 (DE)
Inventor: JAKOBOVITS AYA
IPC: C12N15/79
Filed: 1997-03-19
Granted: 2006-09-21
Abstract: Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between (1) a targeting construct containing a promoter and a switch region (S1) and (2) a target locus minimally containing a promoter, a switch region (S2) and a target sequence.
Patent DE-69739783-D1 (DE)
Inventor: DOUGLAS JOEL S
IPC: A61B5/15
Filed: 1997-05-16
Granted: 2010-04-08
Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by glancing a portion of a user's skin, preferably in an area other than a finger tip to form an incision. After the needle (42) has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member (64) is mounted to an end of a lancet carrying housing (40) for applying the force. The stimulator member (64) can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid
Patent DE-69806395-D1 (DE)
Inventor: BEVERIDGE EDWARD
IPC: D02G3/34
Filed: 1998-04-21
Granted: 2002-08-08
Abstract: Composite stipple yarn and method of manufacture in which the yarn has two types of thread (2, 4), one thread (4) having a lower count than the other thread or threads (2). One type of thread (4) has a different affinity to a predetermined dye to that of the other thread or threads (2). The composite yarn is overdyed in the predetermined dye. This dyes only those threads (4) of one type which are susceptible to the dye, but does not change the colour of the other type of thread (2). This improves stock control and the speed at which a desired stipple yarn can be supplied.
Patent DE-69807699-D1 (DE)
Inventor: SHIEBER STUART M
IPC: G06F17/27
Filed: 1998-06-26
Granted: 2002-10-10
Abstract: A system and method of allowing a user to control a computer application with spoken commands, include the steps of processing the spoken commands with a Speech Recognition application into candidate word phrases, and parsing at least one candidate word phrase with a Context Free Grammar (CFG) parser, into a parse tree. A plurality of predefined rewrite rules grouped into a plurality of phases applied are to the parse tree, for rewriting the parse tree. Each of the plurality of rewrite rules includes a pattern matching portion, for matching at least a part of the parse tree, and a rewrite component, for rewriting the matched part. A command string is produced by traversing each terminal node of the modified parse tree. The command string is sent to an interpreter application or directly to the computer application. Possible applications include word processing and other voice-entry systems.
Patent DE-69815516-D1 (DE)
Inventor: BARTOCCI EZIO
IPC: A23L9/10
Filed: 1998-06-24
Granted: 2003-07-17
Abstract: The subject of the present invention is a cereal-based food, particularly a "rice milk", prepared particularly for human consumption. More particularly, the present invention relates to a food comprising a cereal-based component of vegetable origin and a component of animal origin based on milk or milk derivatives, characterized in that the lactose content is no greater than 10% by weight, calculated with reference to the total weight of solids. According to a preferred aspect, the food according to the present invention has a complex carbohydrates content no less than 30% by weight and a protein content no less than 10% by weight, calculated with reference to the total weight of solids.
Patent DE-69817180-D1 (DE)
Inventor: LOGAN ANN
IPC: A61P25/00
Filed: 1998-06-10
Granted: 2003-09-18
Abstract: The invention features a method for promoting neural growth in vivo in the mammalian central nervous system by delivering a composition comprising a combination of neurotrophins to promote neural growth. Active fragments, cognates, congeners, mimics, analogs, secreting cells and soluble molecules thereof, and DNA molecules, vectors and transformed cells capable of expressing them are similarly utilizable in the methods of the instant invention.
Patent DE-69819674-D1 (DE)
Inventor: ROURA ARES JUAN
IPC: H05B41/14
Filed: 1998-12-16
Granted: 2003-12-18
Abstract: The procedure consists on a single balast which is suitable for one individual tube and feeds successively multiple identical fluorescent lamps, which are connected in parallel with the balast terminals, illuminating a single lamp in a set of fluorescent lamps and continuing to light from one lamp to the next automatically when the operating lamp stops working. <IMAGE>
Patent DE-69820878-D1 (DE)
Inventor: CONNOR FREDERICK
IPC: A61F11/08
Filed: 1998-01-20
Granted: 2004-02-05
Abstract: An earplug includes an electro-magnetically detectable material comprising an alloy of copper with at least one other metal, especially an alloy of copper and tin.
Patent DE-69822474-D1 (DE)
Inventor: MANNING NOEL CHRISTOPHER
IPC: E04D13/076
Filed: 1998-06-11
Granted: 2004-04-22
Abstract: A device for clearing accumulated debris from eave-level rainwater gutters on buildings, comprising a travelling member (3) adapted to be positioned on or in the gutter with sufficient clearance below the overhanging edge of the roof cover for placement, operation and subsequent removal of said member, a substantially rigid longitudinal handle (7) for moving said member to and fro longitudinally of the gutter, for manipulation by a person working below the gutter, for example at ground level or on a balcony intermediate the ground level and the gutter being cleared. Optionally the handle is extensible and contractible, for example telescopically, to allow for clearing gutters at different heights. The device also includes means associated with the travelling member for dislodging any debris and forwarding it to the downpipe for disposal. The dislodging means comprises a water conduit (2) terminating in a directional nozzle (4) mounted on the travelling member, and means for supplying water to said conduit at high pressure to produce a jet effective to dislodge the debris; optionally the dislodging means is complemented by a sweeping block mounted on the travelling member to occupy a cross-sectional region of the gutter upstream of the jet for sweeping the dislodged debris in one direction of travel of the travelling member; optional a powered pump (5) is used to produce water at high pressure and optionally a closed circuit television unit is used to monitor progress in clearance.
Patent DE-69837629-D1 (DE)
Inventor: MCGILL SHANE ROBERT
IPC: B65D51/32
Filed: 1998-10-27
Granted: 2007-05-31
Abstract: In blending food products, particularly milkshakes, a container (3) is provided which has a lid (2) which seals the upper end of the container and has blending means in the form of a rotatable blending element (1), extending, in use, into the body of the container to blend the contents. The container is filled, the lid (2) applied and the container is inverted so that with the blending element (1) rotating, the contents are blended. Thereafter the lid is removed or opened to access the blended contents.  The invention also provides a seating for the container during blending which may embrace the sides of the container, an optional heater or a cooler to cool the contents before blending.
Patent DE-69903620-D1 (DE)
Inventor: ROQUES BERNARD
IPC: A61P25/00
Filed: 1999-04-20
Granted: 2002-11-28
Abstract: The invention concerns (alpha-aminophosphino) peptide derivative compounds of general formula (I) wherein: R1 and R2 represent each a hydrogen atom or together form an imine with the adjacent nitrogen atom; R3 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all said groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally a methyl group substituted by an aromatic or saturated heterocyclic group; R4 represents a CH(X)-(O)-C(O)-Y group or a CH2CH2-S-C(O)-W group; R5 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all said groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally a methyl group substituted by an aromatic or unsaturated heterocyclic group; R6 and R7 can in particular represent a hydrogen atom, an alkyl group, a phenyl group substituted or not; R8 represents an alkyl, alkenyl, phenyl or benzyl group; n=0 or 1, in the form of enantiomers, diastereoisomers or racemic mixtures, their salts, the method for preparing them and their therapeutic applications.
Patent DE-69914952-D1 (DE)
Inventor: DUGAN ANDREW
IPC: H04M3/42
Filed: 1999-10-20
Granted: 2004-03-25
Abstract: System and methodology for providing real-time call processing services received at a switch (158) in an intelligent network having one or more service nodes (204) having originating switches for receiving a call event. The system includes a platform-independent communication system for enabling communication between object instances executing at service nodes (204) in the intelligent network. An operating system agent object (204) instance executing in an execution environment associated with an originating switch communicates call origination information corresponding to a call event received at the switch to one or more object instances executing in an execution environment provided at a service node (204) in the network; the object instances including a line object instance for maintaining the state of a communications line associated with a call origination, and, a service object implementing methods for performing a service according to a customer request.
Patent DE-69917206-D1 (DE)
Inventor: DESROSIERS J
IPC: B01L3/00
Filed: 1999-09-03
Granted: 2004-06-17
Abstract: A method for screening a catalyst library, the method comprising: combining each of a plurality of catalysts of the catalyst library with at least one reactant so as to form a plurality of reaction mixtures, contacting a fluid sample from one of the reaction mixtures with a sorbent, the sorbent being highly selective for at least one component of the fluid sample, selectively trapping the at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample while the at least one component is trapped on the sorbent, the contacting step, the trapping step, and the detecting step being carried out at least once for each of the plurality of reaction mixtures, and the detecting step is carried out for at least two of the reaction mixtures simultaneously.
Patent DE-69917636-D1 (DE)
Title: Polymerasesignalversuch
Inventor: BOYCE-JACINO T
IPC: C12Q1/6834
Filed: 1999-06-15
Granted: 2004-07-01
Abstract: The present invention relates to the field of nucleic acid sequence analysis. The invention provides methods for performing a polymerase signal assay (PSA) to analyze nucleotide sequences using solid phase sequence arrays comprising a plurality of sequence reagents with primer sequences 4-6 bases in length. The methods of the invention generate a binary signal pattern which can be used to identify nucleic acid sequences and/or mutations and polymorphisms of a nucleic acid sequence. Mutations and polymorphisms which can be identified by the methods of the invention include single nucleotide polymorphisms (SNP's), base deletions, base insertions, and heterozygous as well homozygous polymorphisms.
Patent DE-69919226-D1 (DE)
Inventor: HUMAN JAN PETRUS
IPC: B29C48/305
Filed: 1999-07-30
Granted: 2004-09-09
Abstract: The apparatus disclosed comprises a barrel (12) in which there is a piston (42) on a shaft (36). The shaft (36) can be moved axially and is surrounded by a feed screw (14). There is a shut-off valve (70) in the barrel (12). The feed screw (14) is used to fill a holding cavity (C) between the piston (42) and the valve (70). The valve is then opened and the piston (42) forces the charge from the cavity (C) into the moulding cavity (30). In its forward position, the piston (42) has its front face forming part of the bounding wall of the moulding cavity (30).
Patent DE-69928049-D1 (DE)
Inventor: YOSHIKAWA MINORU
IPC: H05K7/20
Filed: 1999-07-28
Granted: 2005-12-08
Abstract: For use in an electronic device having a plurality of multistage circuit boards therein, the present invention provides a cooling system, which supplies a cooling wind to the circuit boards at an equal speed. The present invention provides the system comprising a plurality of inlet-side guides arranged in parallel on an inlet port side of the plurality of circuit boards in a direction of a flow of the air taken in from an inlet port and each inclined at a predetermined angle toward a side opposite to the inlet port and a plurality of fans blowing onto the circuit boards the air guided by the plurality of inlet-side guides. The system further comprises a mesh member between the inlet-side guides and the fans. <IMAGE>
Patent DE-69928375-D1 (DE)
Inventor: SHULOV AHARON DI
IPC: A61K35/58
Filed: 1999-01-13
Granted: 2005-12-22
Abstract: A substantially non-toxic fraction isolated from the venom of Vipera xanthina is disclosed which fraction has an analgesic effect. The fraction is preferably purified on an ion exchange column from Vipera xanthina palestinae. Also described are a pharmaceutical composition for use as an analgesic comprising the non-toxic fraction, and a method for the relief of pain comprising administrating the non-toxic fraction.
Patent DE-69929977-D1 (DE)
Inventor: JURANITCH C
IPC: G01L3/04
Filed: 1999-06-29
Granted: 2006-04-27
Abstract: A drive coupling arrangement for transmitting torque from a drive arrangement to a gear assembly under test has a first coupler portion attached to the gear assembly under test. The coupler has a polygonal cross-sectional configuration and a plurality of substantially planar surfaces that extend parallel to the predetermined length of axis, in the form of an assembly nut of the gear assembly under test at a rotatory terminal thereof. A second coupler portion is coupled to the drive arrangement and has an internal cross-sectional configuration that accommodates the polygonal cross-sectional configuration of the first coupler portion. The second coupler portion has a plurality of engagement portions that communicate exclusively with a predetermined number of the substantially planar surfaces of the first coupler portion, and is axially translatable along the first coupler portion. Axial loading is absorbed by an elastomeric insert that limits the extent of the engagement between first and second coupler portions. The first and second coupler portions exert a torque against one another via the substantially planar surfaces and the engagement portions, over a predetermined range that is limited by the elastomeric insert, which additionally absorbs axial loading. A resilient biasing element urges the second coupler portion axially upward toward the first coupler portion. An isolation support supports the energy transfer system so as to be translatable in at least one plane of freedom.
Patent DE-69933752-D1 (DE)
Inventor: GERBER H
IPC: C08F6/10
Filed: 1999-03-05
Granted: 2006-12-07
Abstract: The specification discloses a method for the manufacture of a fluorescent polyphenolic product with high UV absorbance, its subsequent epoxidation as well as polyphenolic products and epoxidized derivatives and compositions thereof. The polyphenolic products are prepared by heating glyoxal at a temperature of about 80 DEG  C. to about 100 DEG  C. with a molar excess of a phenol in the presence of an acidic catalyst which is eliminated from the reaction mixture at a temperature below about 170 DEG  C. The total mole ratio of glyoxal to phenol charged to the reaction mixture is about 0.15 to 0.22 moles of glyoxal for each mole of phenol. The glyoxal is added continuously or by stepwise additions to the phenol so as to keep the aldehyde units in the reaction mixture to less than about 70% of the aldehyde units in the total quantity of glyoxal to be charged for making the polyphenol. Water is distilled stepwise or continuously from the reaction mixture. The catalyst is removed from the reaction mixture by further distilling the reaction mixture, generally at higher temperatures. After removal of the catalyst, unreacted phenol is removed by distillation and the reaction mixture is heated at a temperature of about 175 DEG  C. to 200 DEG  C. for about 0.25 hours to about 3 hours to produce a polyphenolic reaction product having high fluorescence, high UV absorbance and high solubility in organic solvents. The polyphenolic reaction product can be epoxidized by conventional means and such epoxy products used in the manufacture of laminates, coatings and adhesives.