baber/WOPTO huggingface dataset:
Patent MY-185925-A (MY)
Title: Interwell tomography methods and systems employing a casing segment with at least one transmission crossover arrangement
Inventor: BITTAR MICHAEL S
Filed: 2015-04-23
Abstract: An interwell tomography method includes casing a first borehole (12) with a casing tubular (154) having at least one transmission crossover arrangement (22), each transmission crossover arrangement having an adapter in communication with a coil antenna (26) that encircles an exterior of the casing tubular. The method also includes deploying, inside the casing tubular, a conductive path (30) that extends from a surface interface (59) to the at least one transmission crossover arrangement. The method also includes providing a set of one or more antennas in a second borehole (12). The method also includes obtaining electromagnetic (EM) measurements for interwell tomography using the at least one transmission crossover arrangement and the set of one or more antennas, where said obtaining involves conveying data or power between the at least one transmission crossover arrangement and the surface interface via the conductive path.
Patent MY-195541-A (MY)
Title: Engineered Immunoglobulins With Altered Fcrn Binding
Inventor: FOSS STIAN
IPC: C07K16/00
Filed: 2017-03-14
Abstract: The present invention relates to compositions and methods for antibody-mediated therapy. In particular, provided herein are engineered immunoglobulins with altered half-life.
Patent MY-191676-A (MY)
Title: Intelligent rice storage cabinet
Inventor: HE ZENGCHENG
IPC: A47J47/02
Filed: 2018-01-18
Abstract: The invention discloses an intelligent rice storage cabinet, which comprises a cabinet body (1), a control device mounted on the cabinet body, and an intelligent control panel (100) arranged on the cabinet body (1) and electrically connected with the control device, wherein the cabinet body is internally equipped with a rice storage bin (2), an openable top door (3) is arranged at the top of the rice storage bin (2), an ultrasonic detector whose detecting end faces towards a lower part in the rice storage bin (2) is arranged on an inner surface of the top door (3), the ultrasonic detector is electrically connected with the control device, an ultraviolet emitter (4) electrically connected with the control device is also mounted on the inner surface of the top door (3), and the cabinet body (1) is also internally equipped with a temperature-control and dehumidification device for blowing air into the rice storage bin (2) and exhausting air from the rice storage bin (2). The intelligent rice storage cabinet of the invention has the advantages of providing a good rice storage environment, enabling sterilization, automatically detecting the amount of rice and enabling automatic quantitative discharge of rice. (Fig. 1)
Patent MY-196973-A (MY)
Title: Mikto-arm star polymers for delivery of therapeutic agents
Inventor: KHAIRIAH H BADRI
IPC: C08F293/00
Filed: 2018-09-24
Abstract: Mikto-arm star polymers were prepared comprising non-charged hydrophilic poly( ethylene oxide) arms and hydrophobic arms comprising a poly(propylene oxide) chain or phytol group. The polymer arms are covalently linked to a hydrophobic crosslinked polyester core formed by ring opening polymerization of a bis-cyclic ester initiated by mono-nucleophilic polymer arm precursors. The mikto-arm star polymers show improved loading capacity for Coenzyme QlO (CoQlO).
Patent MY-196925-A (MY)
Title: Splice member for a cable tray
Inventor: TRAVIS COLE SHELTON
IPC: F16L3/26
Filed: 2019-07-11
Abstract: A cable tray section (12) includes first and second side rails (24), each side rail (24) having opposite longitudinal ends and a length extending between the opposite longitudinal ends. A splice member (16) is secured to one of the first and second rails (24) adjacent one of the longitudinal ends. The splice member (16) includes at least one opening (58) configured to receive a fastener (90) to connect the splice member (16) to another splice member (16) of another cable tray section (12) to attach the two cable tray sections (12) together. The at least one opening (58) has an axis (A) extending along the length of at least one of the first and second rails (24).  FIG. 3
Patent MY-192327-A (MY)
Title: Waste composition estimation device, system, program, method, and data structure
Inventor: MATSUOKA KEI
IPC: F23G5/50
Filed: 2018-07-09
Abstract: A device for estimating composition of waste in a waste pit (3) in which waste of various compositions is mixed, using a learning model is provided. A device comprises: a training data generation unit (220) which generates training data associated with a captured image of waste stored in the waste pit (3); a model construction unit (230) which constructs a model by performing learning using the training data; and an estimation unit (250) which inputs, to the model, data of a new captured image of the waste stored in the waste pit (3), and obtains a value representing composition of the waste corresponding to the new image.   FIG. 3
Patent MY-195277-A (MY)
Title: Steel Sheet for Container and Production Method Therefor
Inventor: SUTO MIKITO
IPC: C25D7/00
Filed: 2018-06-08
Abstract: A steel sheet for containers according to the present invention includes: a tin-plated steel sheet having a tin--plated layer on a surface thereof; a tin oxide film formed on a surface of the tin-plated layer; and a tin phosphate film formed on a surface of the tin oxide film, the tin phosphate film including 0.1 mg/m? to 3.0 mg/m? of tin phosphate as a P coating amount. The tin oxide film has a reduction current peak in a range of -800 to -500 mV vs a saturated KCl-Ag/AgCl reference electrode when the tin oxide film is reduced while the potential is swept from the immersion potential to the lower side in a 0.001N hydrogen bromide aqueous solution. An A value is less than 1.0. An amount of electricity required for reduction of the tin oxide film which is calculated from the reduction current-potential curve of the tin oxide film is 1.5 mC/cm? to 5.0 mC/cm?. (Figure 2)
Patent MY-183251-A (MY)
Title: Aluminum-alloy substrate for magnetic disk, method for manufacturing same and magnetic disk employing said aluminum-alloy substrate for magnetic disk
Inventor: FUJII YASUO
Filed: 2019-02-06
Abstract: Provided is an aluminum alloy substrate for a magnetic disk that includes an aluminum alloy containing 0.4 to 3.0 mass% (hereinafter abbreviated as "%") of Fe, 0.005% to 1.000% of Cu, and 0.005% to 1.000% of Zn, with a balance of Al and unavoidable impurities.	This substrate has a ratio A/B of 0.70 or more, where A indicates a distribution density of Al-Fe intermetallic compound particles having maximum diameters of 10 ?m or more and less than 16 ?m, and B indicates a distribution density of Al-Fe intennetallic compound particles having maximum diameters of 10 ?m or more.The distribution density of Al-Fe intermetallic compound particles having maximum diameters of 40 ?m or more is at most one per square millimeter. Also provided are a method of fabricating this aluminum alloy substrate for a magnetic disk and a magnetic disk composed of the aluminum alloy substrate for a magnetic disk.
Patent MY-154366-A (MY)
Title: An electrodeposition method for producing zinc oxide nanostructures
Inventor: CHEE CHING YERN
IPC: C25D3/22
Filed: 2013-05-02
Abstract: The present invention relates to an electrodeposition method for producing zinc oxide nanostructures, characterized by the steps of preparing an aqueous solution comprising zinc salt in a three electrode reactor; applying a potential voltage in a range of -1V to -2V to the aqueous solution and setting a deposition temperature in a range of 50°C to 90°C at a deposition time about 15 to 60 minutes for depositing the zinc oxide at an electrically semiconductive substrate of the three electrode reactor; wherein the electrically semiconductive substrate is a glass substrate with a fluorine-doped tin oxide layer.
Patent SG-10201900657X-A (SG)
Title: Access system for users of a refuse container and method for operating an access system for refuse containers
Inventor: HANAUER THOMAS
Filed: 2019-01-24
Abstract: Access system for users of a refuse container and method for operating an access 5 system for refuse containers The present invention relates to a system (1) for checking and controlling access for a user to a refuse container (2), comprising a refuse container (2) having an electronic control unit 10 (3) that comprises a first communication interface (4) for sending and receiving data and a server (5) that is arranged at a distance from the refuse container and comprises a second communication interface (6), an authentication manager (7) and a database (8), it being pos- sible to initiate a transfer of data (11) between the first communication interface (4) and a third communication interface (10) of a communication apparatus (9), which apparatus can 15 be assigned to a user, in order to identify a user before using the refuse container (2), the authentication manager (7) assigning user data (12) from the database (8) to the data (11) and giving or denying access to said refuse container (2) for said user on the basis of this assignment, the first communication interface (4) not comprising any devices for directly transferring data to the second communication interface (6), the communication apparatus 20 (9) that can be assigned to the user comprising an interface device, via which indirect data transfer between the first communication interface (4) and the second communication inter- face (6) can be initiated. The invention also relates to a method for checking and controlling access for a user to a refuse container. 25 (Fig. 1)
Patent SG-11201407812S-A (SG)
Title: Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives
Inventor: GAGNON PETER
IPC: C07K1/14
Filed: 2013-02-06
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/180650 A1 (51) International Patent Classification: C07K1/14( 2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/SG2013/000049 6 February 2013 (06.02.2013) English English (30) Priority Data: 61/653,752 31 May 2012 (31.05.2012) US (71) Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis, Singapore 138632 (SG). (72) Inventor: GAGNON, Peter; 20 Biopolis Way, #06-01 Centres, Singapore 138668 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road, Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) © o 00 i-H en i-H o CJ o & (54) Title: METHODS FOR REDUCING LEVELS OF PROTEIN-CONTAMINANT COMPLEXES AND AGGREGATES IN PROTEIN PREPARATIONS BY TREATMENT WITH ELECTROPOSITIVE ORGANIC ADDITIVES (57) Abstract: Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low con­ centrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
Patent SG-11201804967W-A (SG)
Title: Elevator system having destination call control
Inventor: THOEBEL JAN-KARSTEN
IPC: B66B1/46
Filed: 2016-12-16
Abstract: IPWO15- Elevator system having destination call control and having a device for displaying video data in the region of an elevator system and a method for operating an elevator system having destination call control 5 The invention relates to an elevator system (10) having destination call control and having a dis- play system (18) comprising at least a device (20) for displaying video data in the form of a projec- tion (38) in the region of the elevator system (10), and a method for operating the same whereby a respective projection (38) of the at least one device (20) can be influenced by means of selection of 10 a destination floor made as part of the destination call control, and is influenced/predefined during an execution of the method. (Fig. 1) 15
Patent SG-11201808797X-A (SG)
Title: T cell receptors
Inventor: HAYES CONOR
IPC: C07K14/725
Filed: 2017-04-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011111100111011011101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number ..... .....!;,,, (43) International Publication Date WO 2017/175006 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: KILBURN & STRODE LLP; 20 Red Lion Street, CO7K 14/725 (2006.01) London, Greater London, WC1R 4PJ (GB). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/GB2017/050985 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 7 April 2017 (07.04.2017) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 1606009.7 8 April 2016 (08.04.2016) GB RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: IMMUNOCORE LIMITED [GB/GB]; 101 ZA, ZM, ZW. Park Drive, Milton Park, Abingdon Oxfordshire OX14 4RY (GB). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: HAYES, Conor; c/o Immunocore Limited, 101 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Park Drive, Milton Park, Abingdon Oxfordshire OX14 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 4RY (GB). HIBBERT, Linda; c/o Immunocore Limited, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 101 Park Drive, Milton Park, Abingdon Oxfordshire OX14 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 4RY (GB). LIDDY, Nathaniel; c/o Immunocore Limited, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 101 Park Drive, Milton Park, Abingdon Oxfordshire OX14 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 4RY (GB). MAHON, Tara; c/o Immunocore Limited, 101 GW, KM, ML, MR, NE, SN, TD, TG). — _ Park Drive, Milton Park, Abingdon Oxfordshire OX14 4RY RAMAN, Marine; Immunocore Limited, Published: = (GB). c/o 101 Park Drive, Milton Park, Abingdon Oxfordshire OX14 — with international search report (Art. 21(3)) 4RY (GB). = = = = = = = = = = = = 1-1 ,tD 0 0 1 1 in IN ,—, IN 1-1 (54) Title: T CELL RECEPTORS 0 ei (57) : The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide GVYDGREHTV en. ) (SEQ ID NO: 1) derived from the germline cancer antigen MAGE A4. Said TCRs may comprise non-natural mutations within the al- pha and/or beta variable domains relative to a native MAGE A4 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.
Patent SG-11201903202V-A (SG)
Title: Osmotic membrane
Inventor: GOVINDAN PRAKASH
IPC: B01D69/10
Filed: 2017-10-18
Abstract: Title: OSMOTIC MEMBRANE 34 .,4•t' , :' , ,.., \‘‘\ ,AReigh,g:....:::::,.... \ FIG. 5 N N O 00 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 April 2018 (26.04.2018) WIP0 I PCT omit °nolo olo olo limo oimIE (10) International Publication Number WO 2018/075637 Al (51) International Patent Classification: BOlD 61/02 (2006.01) BOlD 69/12 (2006.01) BOlD 69/10 (2006.01) (21) International Application Number: PCT/US2017/057186 (22) International Filing Date: 18 October 2017 (18.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/410,170 19 October 2016 (19.10.2016) US (71) Applicant: GRADIANT CORPORATION [US/US]; 225 Wildwood Avenue, Woburn, Massachusetts 01801 (US). (72) Inventors: GOVINDAN, Prakash; Gradiant Corporation, 225 Wildwood Avenue, Woburn, Massachusetts 01801 (US). CHOONG, Looh Tchuin; Gradiant Corporation, 225 Wildwood Avenue, Woburn, Massachusetts 01801 (US). (74) Agent: SAYRE, Robert; Modern Times Legal, 1 Broad- way, 14th Floor, Cambridge, Massachusetts 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 38 1-1 (57) : An osmotic membrane comprises an active layer and a composite support layer. The active layer selectively allows © passage of water molecules but rejects at least some dissolved ions. The composite support layer includes a side that is bonded to the active layer and comprises an electrospun-fiber sub-layer and a phase-inversion sub-layer. C
Patent SG-11201906111P-A (SG)
Title: An expandable multi-physiological parameter monitoring ring
Inventor: ZHOU CONGCONG
IPC: A61B5/021
Filed: 2018-12-07
Abstract: AN EXPANDABLE MULTI-PHYSIOLOGICAL PARAMETER MONITORING RING The present invention relates to the field of health medical device, and discloses an 5 expandable - physiological monitoring The multi - physiological parameter monitoring ring in embodiments of the present invention includes a microprocessor module and an internal sensor module connected to the microprocessor module, further an module detachably to microprocessor and used connect ing an sensor The 10 microproc essor module is configured to: when the external module interface is connected to the external sensor module, obtain measurement signals from the external sensor module and the internal sensor module, and process the measurement signals to obtain a differe nce between a measurement signal of the external sensor module and a measurement signal of the internal sensor module; and when the external module interface is not connected to the 15 external sensor module, calibrate, according to the difference, a physiolo gical parameter obtained by the internal sensor module. The present invention can improve accuracy of physiological parameter measurement at a fingertip, and can implement low load, portability , and comfort. 20 (FIG. 1) 25 30
Patent IS-2294-B (IS)
Inventor: WESTPHAL OTTO
IPC: A61K38/42
Filed: 2005-07-18
Abstract: The present invention relates to a composition comprising bacterial endotoxin, fetal hemoglobin and, optionally, additional components such as additional fetal liver components and a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that bacterial endotoxin and fetal hemoglobin display a pronounced synergistic biomedical activity. The composition of the invention finds a variety of applications including the stimulation of the immune system, the prevention and/or treatment of cancer, infections such as viral infections and/or allergic conditions and the reversion of age-related immune imbalances. <IMAGE>
Patent IS-2310-B (IS)
Inventor: KROMER ROBERT
IPC: A61P25/16
Filed: 2006-05-26
Abstract: This invention pertains to a liquid intranasal pharmaceutical formulation comprising a pharmaceutically acceptable acid addition salt of rotigotine and  alpha -cyclodextrin, preferably in the form of a buffered aqueous solution having a viscosity of 0.5 - 1.5 mm<2>/s
Patent YU-48755-B (YU)
Inventor: TEH DORDEVIC RADOMIR MAS
Filed: 1993-01-28
Abstract: Univerzalna kutija sa promenljivom zapreminom, koja se koristi kao ambalaža za uskladištenje ili transportovanje predmeta ili materijala u prometu roba, naznačena time, što je unutar veće kutije (1) sa poklopcem (4) smeštena manja kutija (2) sa poklopcem (3), pri čemu se manja kutija (2) sa poklopcem (3) može klizno izvlačiti, preko U-profilisanih vođica (5), iz veće kutije (1), na isti način kao i poklopac (3) manje kutije (2) iz vođica (5') i što su obe kutije (1,2) međusobno spojene trakom (6). - Prijava sadrži još 4 zavisna zahteva.
Patent AT-406829-B (AT)
Title: Process and device for microfiltration during waste-water purification
IPC: B01D65/02
Filed: 1999-04-28
Granted: 2000-09-25
Abstract: Waste water is filtered in a tank, for example in an activated sludge tank, by means of at least one membrane which is cleaned by back-washing, filtered purified water being discharged; a membrane which is perforated by needling and in regions is supported by at least one support body, while leaving clear regions for medium to flow through, is used for filtering the waste water, and for the back-washing, air is periodically passed through the membrane in the opposite direction. <IMAGE>
Patent DK-164282-B (DK)
Inventor: ANDERSSON LARS-OLOF
IPC: A61K35/16
Filed: 1986-02-25
Abstract: Novel, biologically active fragments of human anti- hemophilic factor, processes for their preparation, pharmaceutical preparations containing them and the use of such fragments in the treatment of patients suffering from haemophilia.