baber/WOPTO huggingface dataset:
Patent DE-60234092-D1 (DE)
Inventor: MACDONALD TIMOTHY L
IPC: A61P25/06
Filed: 2002-01-30
Granted: 2009-12-03
Abstract: The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I), wherein R<SUB>1 </SUB>is C<SUB>8</SUB>-C<SUB>22 </SUB>alkyl, C<SUB>8</SUB>-C<SUB>22 </SUB>alkenyl or R<SUB>12 </SUB>is O, or R<SUB>1 </SUB>and R<SUB>12 </SUB>taken together form an optionally substituted aryl or an optionally substituted heteroaryl; R<SUB>17 </SUB>is H, alkyl or alkylaryl; R<SUB>18 </SUB>is N or CH; R<SUB>2 </SUB>and R<SUB>3 </SUB>are independently selected from the group consisting of H, NH<SUB>2</SUB>, and OH, with the proviso that at least one of R<SUB>2 </SUB>and R<SUB>3 </SUB>is NH<SUB>2</SUB>; R<SUB>4 </SUB>is selected from the group consisting of hydroxyl, phosphate, phosphonate methylene phosphonate, alpha-substituted methylene phosphonate, thiophoasphate and thiophosphonate; and R<SUB>5 </SUB>is C<SUB>8</SUB>-C<SUB>22</SUB>alkenyl.
Patent DE-60234183-D1 (DE)
Inventor: MOSS JONATHAN
IPC: A61P25/36
Filed: 2002-06-05
Granted: 2009-12-10
Abstract: Methods for treating opioid-induced immune suppression with peripheral opioid antagonists are provided. In one embodiment, the method involves administering methylnaltrexone. Pharmaceutical compositions comprising an opioid, an opioid antagonist, and a pharmaceutical agent are also provided.
Patent DE-60235413-D1 (DE)
Inventor: HARDY STEPHEN F
IPC: C07K16/10
Filed: 2002-12-09
Granted: 2010-04-01
Abstract: A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5'LTRs; (3) a fragmented 3'LTR; (4) an  env  gene interrupted by an alu insertion; and (5) unique gag sequences.
Patent DE-60237993-D1 (DE)
Inventor: WANG LONGGUI
IPC: C07H19/02
Filed: 2002-12-13
Granted: 2010-11-25
Abstract: A compound called NATURA, which is a derivative of Isoindigo is useful in aiding the general health of a patient and specifically is beneficial in preventing or treating cancer. This compound and other related Isoindigo, Indigo and Indirubin derivatives are designed such that the bioactivity or bioavailability of the compound is increased. Methods of synthesizing these derivatives is also taught. In addition, pharmaceutical compositions that include a therapeutically effective amount of at least one of these derivatives and a pharmaceutically acceptable carrier. A method for the use of these pharmaceutical compositions and compounds is taught, wherein a therapeutically effective amount is administered to an animal having solid tumor cancer. The pharmaceutical composition or compound can be re-administered to the animal until a desired treatment or result is accomplished.
Patent DE-60300615-D1 (DE)
Inventor: LIN JUI-YUAN
IPC: B25C5/16
Filed: 2003-02-25
Granted: 2005-06-09
Abstract: A stapling apparatus (23) with a safety device for a stapler prevents staples from popping out of the stapler (20) when a user troubleshoots the stapler. The stapling apparatus (23) is pivotally attached to a stapler (20) and has a housing (231), a sliding front cover (24) slidably mounted on the housing (231) and a safety device having a positive stop (11) formed on the housing (231) and a stop lip (12) formed on the sliding front cover (24). The sliding front cover (24) is pushed upward to remove lodged staples, the stop lip (12) abuts the positive stop (11) to limit movement of the sliding front cover (24). Therefore, the staples are still held in the housing (231) by the sliding front cover (24). <IMAGE>
Patent DE-60304867-D1 (DE)
Inventor: GYGAX RUDOLF
IPC: A63J5/00
Filed: 2003-07-22
Granted: 2006-06-01
Abstract: A fragrance cartridge comprising a reservoir containing a fragrance material and provided with channels to permit ingress of carrier gas into the reservoir and egress of fragrance-containing carrier gas from the reservoir, the channels being defined by capillaries having internal diameter and length dimensions sufficient to act as closure means to prevent, or substantially prevent, leakage of fragrance from the reservoir into a head space external of the cartridge when carrier gas flow is interrupted. The cartridge can be used for example to enhance the sensorial perception of a viewer, listener or consumer of an audio and/or visual performance or presentation, by passing fragrance borne on the carrier into a head space local to the listener, viewer or consumer.
Patent DE-60307669-D1 (DE)
Inventor: JOHNSTON H
IPC: A01K45/00
Filed: 2003-11-10
Granted: 2006-09-28
Abstract: A spray delivery system and methods of use thereof, suitable for delivering a fan-shaped vaccine spray to birds or chicks held within an open-topped container, comprising a cover, an elongated guide rail mounted thereon, and a spray head may move reversibly on the guide rail. The spray head comprises a spray nozzle assembly having a spray port and optionally a fan-shaped nozzle for delivering a fan-shaped fluid spray. The cover has an elongated slot that permits the spray nozzle assembly to extend below the plane of the cover while allowing the spray nozzle assembly to freely traverse the length of an open-topped container placed beneath the cover. By reversibly moving the spray head along the guide rail, the spray delivery system can deliver a substantially uniform fluid spray to an open-topped container with minimal overspray and reduced fluid wastage.
Patent DE-60309198-D1 (DE)
Inventor: TURAN HALIL
IPC: E05D11/00
Filed: 2003-11-21
Granted: 2006-11-30
Abstract: The subject of invention has enabled the change of the door opening direction in electronic controlled refrigerators (1) by taking out the top hinge (18) and the cable group (5, 6), when desired, the cables which are let out from the upper ceiling and are mounted to the top hinge (18) with a socket (11, 12) can be removed from its socket (11, 12) and the top hinge can be taken to the other side.
Patent DE-60313802-D1 (DE)
Inventor: BRADY FRANK
IPC: C07B59/00
Filed: 2003-12-19
Granted: 2007-06-21
Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX  (I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X  (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.
Patent DE-60322482-D1 (DE)
Inventor: MORISHITA RYUICHI
IPC: A61K48/00
Filed: 2003-08-08
Granted: 2008-09-11
Abstract: The feasibility of gene therapy using NO synthase (NOS) to treat peripheral arterial disease was examined. According to the present invention, transfection of NOS vector resulted in a significant increase in blood flow and capillary density. Thus, the present invention provides use of a NOS gene for preparing a naked DNA vector for treating or preventing angiogenesis-dependent conditions. <IMAGE>
Patent DE-60331969-D1 (DE)
Inventor: BOSSIDAN BECKY
IPC: G03G9/09
Filed: 2003-10-29
Granted: 2010-05-12
Abstract: A black toner particle for use in a printing toner, the particle comprising: a polymer: carbon black; and a plurality of different colored pigments; wherein the carbon black and pigments are dispersed in the polymer.
Patent DE-60334312-D1 (DE)
Inventor: BONNE ADAM
IPC: F16K15/02
Filed: 2003-10-21
Granted: 2010-11-04
Abstract: An apparatus for controlling flow in a flowline under pressure, said apparatus comprising a flow passage having a firs end and a second end, and hindering means for reducing the flow in the flow passage, the hindering means being arranged to move between a first and a second position under influence of a pressure difference between the first end and the second end of the flow passage. The reduction of the flow in the flow passage is larger when the hindering means is in the first and second position than when the hindering means is in an intermediate position between said first and second positions. Hereby an improved safety valve, which is adapted to shut off flow in a flow line in two directions, is provided.
Patent DE-60334442-D1 (DE)
Inventor: BAKER KENNETH R
IPC: H04B7/14
Filed: 2003-01-07
Granted: 2010-11-18
Abstract: An apparatus and method for identifying remote communications transmitted via a repeater from remote communications not transmitted via the repeater. The method comprises the steps of receiving a plurality of signal transmissions originating from a plurality of remote stations, wherein each of the signal transmissions is associated with a call originating from one of the plurality of remote stations; processing the plurality of received signal transmissions to identify received transmissions that include a discriminant applied by a repeater; and designating each of the plurality of received signal transmissions as being transmitted via the repeater if the received signal transmission includes the discriminant.
Patent DE-68900249-D1 (DE)
Inventor: SEROO JAN MATHIJS
IPC: B23F23/12
Filed: 1989-02-23
Granted: 1991-10-17
Abstract: A process for the making and/or finishing of a crown wheel (1) using a metal-cutting tool (8), said crown wheel being intended for meshing with a predetermined cylindrical gear (2). The metal-cutting tool is a rotary disc-type element whose working transverse section (10) lying in the plane of the axis of rotation corresponds essentially to the tooth profile of the cylindrical gear. The disc-type element is placed in such a way relative to the crown wheel to be made that the tooth profile of the said element coincides with the tooth profile of the cylindrical gear when it is engaged with the crown wheel. The disc-type element is put into a to and fro linear motion perpendicular to its axis of rotation and is at the same time tilted about an axis (6) which coincides with the axis of rotation of the cylindrical gear when it is engaged with the crown wheel. The tooth profile (10) of the said element meshing with the crown wheel to be made and finishes the tooth flanks according to the generating principle.
Patent DE-68921451-D1 (DE)
Inventor: KRISHNAKUMAR SUPPAYAN M
IPC: B29C49/22
Filed: 1989-11-22
Granted: 1995-04-06
Abstract: A plastic preform from which a plastic container is blow molded. The preform replaces a three layer preform by providing a preform which is of a five layer construction in the base forming portion thereof and wherein a secondary material which forms the core layer of the three layer preform construction is divided into an inner intermediate layer and an outer intermediate layer by a third injection of material. The third injected material is preferably the same material as the primary material which is first injected. This results in the reduction of the cost of the preform and also provides remaining in the injection nozzle a quantity of the last injected material which is the same as the first injected material for the following preform in the same preform injection mold cavity. <IMAGE>
Patent DE-68921648-D1 (DE)
Inventor: HERMANN ALLEN M
IPC: C04B35/45
Filed: 1989-01-16
Granted: 1995-04-20
Abstract: Novel high temperature superconducting system compounds have the general composition Tl-R-X-Y, wherein: R represents a Group 2A element; X represents a Group 1B element; and Y represents a Group 6B element. Preferably, the compounds have the general formula Tl-Ba-Cu-O. The high temperature superconductor compounds may have transition temperatures of about 90 K with the probability of one phase superconducting at a temperature perhaps as high as 270 K. Processes for making these high temperature superconductor compounds are also disclosed.
Patent DE-68921693-D1 (DE)
Inventor: CLARK EDWARD TIMOTHY
IPC: H04B1/10
Filed: 1989-10-27
Granted: 1995-04-20
Abstract: A transceiver determines the signal quality of a desired signal and the strength of all received signals. When the signal quality of the desired signal is low, and the signal strength of all received signals is high, the receiver is adapted to operate in a higher current mode, thereby minimizing intermodulation distortion. Conversely, when the quality of the desired signal is low and the strength of all received signals is also low, or when the quality of the desired signal is above a threshold, the receiver operates in a lower current mode to conserve power and maximize battery lifetime. Also, when the transceiver adapts to operate in the higher current mode, a command is sent instructing a transmitting party to increase the quality of their message which may enable the listening transceiver to adapt (return) to a lower current mode.
Patent DE-68924215-D1 (DE)
Inventor: LEVY JULIA G
IPC: A61K41/00
Filed: 1989-07-19
Granted: 1995-10-19
Abstract: A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
Patent DE-69002743-D1 (DE)
Inventor: ASKANAZI JEFFREY
IPC: A61K31/195
Filed: 1990-11-26
Granted: 1993-09-16
Abstract: A method for improving ventilation during sleep and treating sleep-related ventilation abnormalities. To this end, the present invention provides a method of using branched-chain amino acids as an effective therapy for sleep apnea. The branched-chain amino acid composition can be administered either parenterally or enterally, and can be administered alone or in combination with other nutrients. The branched-chain amino acid composition of the present invention functions as a ventilatory stimulator during sleep and does not result in any adverse effects either to the patient or to the sleep patterns of the patient. Preferably, the branched-chain amino acids comprise 60 to 85% of an amino acid solution that is administered to the patient. <IMAGE>
Patent DE-69011204-D1 (DE)
Inventor: KARLSSON ROGER SVEN
IPC: B01D46/04
Filed: 1990-04-30
Granted: 1994-09-08
Abstract: The present invention relates to a device at a filter hose, forming part of a hose filter, whereby contaminated gases (7) are brought to flow into the filter hose (6) for depositing contaminants (9) on the outer side of the filter hose (6), whereby the gases are brought to flow out of the filter hose (6) to a clean-gas zone (11) through a sleeve (14), whereby at least one compressed-air nozzle (17) is provided in the clean-gas zone (11) at a distance from the sleeve (14) and adapted to guide a blow-like flow (18) of compressed air through the sleeve (14) into the filter hose (6) for momentarily expanding said hose and thereby loosen the contaminants (9) deposited on the outer side of the filter hose (6), and whereby the sleeve (14) has an end portion (14a) defining a compressed-air discharge zone (24) through which the compressed air flows from the sleeve (14) into the filter hose (6). In order to ensure that no unfavourable spaces are provided between the outer side of the sleeve (14) and the filter hose (6), said filter hose (6) engages and/or is connected to the end portion (14a) of the sleeve (14).
Patent DE-69014764-D1 (DE)
Inventor: BACHOT JEAN
IPC: C25B9/19
Filed: 1990-07-31
Granted: 1995-01-19
Abstract: Diaphragms comprising asbestos fibres for electrolysis cells, use of such diaphragms in combination with a cathodic member and a process for obtaining such diaphragms and combination of such diaphragms with a cathodic member, by a wet route. 
<??>The invention relates more particularly to a microporous diaphragm capable of being formed in situ by a wet route, comprising an asbestos-based fibrous sheet whose fibres are microconsolidated by a fluoropolymer, the whole being sintered, the said sheet containing essentially from 3 to 35% by weight of fluoropolymer, binding the fibres, from 1 to 50% by weight of a gel of oxohydroxide of at least one metal from groups IVA, IVB, VB and VIB of the Periodic Classification or of the lanthanide and actinide series, from 20 to 95% by weight of fibres, the asbestos fibres representing at least 1% by weight of the said fibres, and its optional use in combination with a precathodic sheet. 
<??>These diaphragms and combinations can be employed especially in chlorine-soda electrolysis cells.
Patent DE-69018571-D1 (DE)
Inventor: FUNABIKI MASAKI - -
IPC: B01J37/03
Filed: 1990-06-08
Granted: 1995-05-18
Abstract: Exhaust gas purificn. catalyst consists of a monolithic support coated with a catalytic layer which contains activated alumina; at least one Pt gp. element (such as rhodium); cerium oxide; a copptd. oxide of zirconium stabilised by cerium; and opt. a zirconium cpd. The copptd. oxide of Zr stabilised by Ce pref. contains 99-75% by wt. (esp. 95-85%) Zr oxide and 1-25% (esp. 5-15%) Ce oxide. The catalyst is produced by coating the support with a slurry contg. the above components, and firing.
Patent DE-69024068-D1 (DE)
Inventor: FITE DAVID B
IPC: G06F9/38
Filed: 1990-01-31
Granted: 1996-01-25
Abstract: In a pipeline processor, simultaneous decoding of multiple specifiers in a variable-length instruction causes a peculiar problem of an intra-instruction read conflict that occurs whenever an instruction includes an autoincrement or an autodecrement specifier which references either directly or indirectly a register specified by a previously occurring specifier for the current instruction. To avoid stalls during the preprocessing of instructions by the instruction unit, register pointers rather than register data are usually passed to the execution unit because register data is not always available at the time of instruction decoding. If an intra-instruction read conflict exists, however, the operand value specified by the conflicting register specifier is the initial value of the register being incremented or decremented, and this initial value will have been changed by the time that the execution unit executes the instruction. Preferably, the proper initial value is obtained prior to the incrementing or decrementing of the conflicting register by putting the instruction decoder into a special IRC mode in which only one specifier is decoded per cycle, and if a specifier being decoded is a register specifier, the content of the specified register is transmitted to the execution unit. Circuitry for detecting an intra-instruction read conflict is disclosed as well as an efficient method for handling interrupts, exceptions and flushes that may occur during the processing of an instruction having an intra-instruction read conflict.
Patent DE-69031951-D1 (DE)
Inventor: JOHNSTON STEPHEN
IPC: C12N15/87
Filed: 1990-11-13
Granted: 1998-02-19
Abstract: A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5' to 3' direction, a regulatory sequence operable in the tissue cells and a gene positioned downstream of the regulatory sequence and under the transcriptional control thereof; and (b) accelerating the microprojectiles at the cells, with the microprojectiles contacting the cells at a speed sufficient to penetrate the cells and deposit the polynucleic acid sequences therein. Preferably, the target cells reside in situ in the animal subject when they are transformed. Preferred target cells are dermis or hypodermis cells, and preferred genes for insertion into the target cells are genes which code for proteins or peptides which produce a physiological response in the animal subject.
Patent DE-69103011-D1 (DE)
Inventor: LE MAGNEN CHRISTINE
IPC: A61K8/64
Filed: 1991-06-25
Granted: 1994-08-25
Abstract: PCT No. PCT/FR91/00506 Sec. 371 Date Nov. 13, 1992 Sec. 102(e) Date Nov. 13, 1992 PCT Filed Jun. 25, 1991 PCT Pub. No. WO92/00017 PCT Pub. Date Jan. 9, 1992.A method for obtaining beta casein by separating it from para kappa casein involving the use of rennet casein is disclosed.
Patent DE-69112349-D1 (DE)
Inventor: CHATO JOHN D
IPC: F24H1/26
Filed: 1991-06-13
Granted: 1995-09-28
Abstract: A pulsating combustor includes a combustion chamber having a hollow cylindrical form and a tailpipe having a similar hollow cylindrical form, such that the internal chambers are annular in section. Air and fuel are admitted to the combustion chamber and pulsating combustion is initiated, with exhaust gases being removed from the tailpipe. A water jacket is defined both inside and outside the pulsating combustor, with water being moved from one to the other as it is being warmed. Fuel is preferably admitted along needles or short pipes which are such as to have a natural resonant frequency which is a small number multiple of the natural resonant frequency of the combination of the combustion chamber and the tailpipe. Preferred frequencies are 440 cps for the combination combustion chamber and tailpipe, and 1320 cps for the fuel delivery needle or pipe.
Patent DE-69117571-D1 (DE)
Inventor: LANDEL ERIC
IPC: G10K11/178
Filed: 1991-04-18
Granted: 1996-04-11
Abstract: The process involves the insertion of at least one transducer into the wall of a pipe belonging to this circuit. The transducer causes the wall to vibrate, thus creating an active moving wall whose radial displacements are in phase opposition to the local acoustic pressure. This produces a condition in which the acoustic waves are not propagated so that waves coming from the pipe towards the transducer are reflected. <IMAGE>
Patent DE-69119077-D1 (DE)
Inventor: MCEWEN STEPHEN
IPC: B01D29/11
Filed: 1991-05-30
Granted: 1996-05-30
Abstract: A filter apparatus (10) for filtering machine tool coolant is disclosed as including a filter assembly (12) including a foraminous non-reticulated metal screen (30) having minute openings and a smooth planar surface for providing improved scrape cleanability and preventing movement of machining chips, particulate and also elongate contaminants from one side of the filter (12) to the other side thereof.
Patent DE-69121361-D1 (DE)
Inventor: SZCZECHURA BERNARD J
IPC: B29L31/48
Filed: 1991-10-31
Granted: 1996-09-19
Abstract: A polymer latex for making gloves or the like having excellent donning and doffing characteristics comprises a carboxylated open chain aliphatic diene. acrylonitrile/(meth)acrylate copolymer. Latex articles having a skin-contacting surface of the copolymer are produced by dipping formers in the latex.
Patent DE-69200147-D1 (DE)
Inventor: BRILLOUET FRANCOIS
IPC: H01S5/227
Filed: 1992-07-13
Granted: 1994-06-30
Abstract: The current supplying an indium phosphide or gallium arsenide laser is confined in a laser stripe (14A) by two means. A nearby current blocking means consists of a blocking junction (JB) formed in two lateral channels (CL) delimiting this stripe. A distant current blocking means consists of an iron-doped semi-insulating layer (24) deposited epitaxially before etching the lateral channels. 
<??>The invention applies in particular to the production of pumping lasers used in the optical amplifiers of fibre optic links. 
<IMAGE>