Patent SG-11202000331Y-A (SG)
Title: Therapeutic modulators of the reverse mode of atp synthase
Inventor: FORREST MICHAEL DAVID
IPC: C07D403/06
Filed: 2018-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 011101 010 VIII VIII 10 o III m VIII OH 0100111E11111° oimIE (43) International Publication Date 17 January 2019 (17.01.2019) (10) International Publication Number WO 2019/012149 Al WIPO I PCT (51) International Patent Classification: CO7D 233/56 (2006.01) A61K 31/4164 (2006.01) CO7D 251/54 (2006.01) A61K 31/551 (2006.01) C07D 403/06 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2018/069175 (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 1711250.9 13 1715756.1 28 1715758.7 28 1715938.5 01 1716492.2 09 1800092.7 04 1800291.5 08 1800581.9 15 PCT/EP2018/051127 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 13 July 2018 (13.07.2018) English English July 2017 (13.07.2017) September 2017 (28.09.2017) September 2017 (28.09.2017) October 2017 (01.10.2017) October 2017 (09.10.2017) January 2018 (04.01.2018) January 2018 (08.01.2018) January 2018 (15.01.2018) GB GB GB GB GB GB GB GB EP GB GB GB GB GB GB Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 1801536.2 1806421.2 1808331.1 1809497.9 1810236.8 1811188.0 17 January 2018 (17.01.2018) 30 January 2018 (30.01.2018) 19 April 2018 (19.04.2018) 21 May 2018 (21.05.2018) 08 June 2018 (08.06.2018) 21 June 2018 (21.06.2018) 08 July 2018 (08.07.2018) Inventor; and Applicant: FORREST, Michael David [GB/GB]; Flat 2, Alington House, Alington Road, Poole Dorset BH14 8LY (GB). Agent: WATSON, Robert et al.; Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). — (54) Title: THERAPEUTIC MODULATORS OF THE REVERSE MODE OF ATP SYNTHASE (57) : Compounds of the following formula (I) slow the ATP-hydrolysing mode of ATP synthase and are useful for treating various diseases and disorders including cancer, particularly cancers that utilise the Warburg effect. R B W O 20 19/0 12149 Al (I) H NH R A2