baber/WOPTO huggingface dataset:
Patent CA-2365105-A1 (CA)
Title: Pulse clock/signal delay apparatus and method
Inventor: ARKAS EVANGELOS
IPC: H03K5/13
Filed: 2000-03-27
Abstract: A Pulse Clock Delay (PCD) apparatus (208) includes a selectable plurality (Nd) of series-connected pulse transition delay units (209) from a total plurality (Nmax) of such units. Each unit provides an incremental transition delay interval .DELTA.~t?. The PCD may be connected to a first intermediate proximal node (nla) and an adjacent electrically isolated second intermediate node (nlb) where the first and second intermediate nodes are in a shorter (215a, 215b) of two signal paths having respective proximal and spaced apart distal ends (212, 216) in an electrical network. Control means (205), responsive to the difference in electrical length between the two signal paths (214, 215), configures the switchable selection means to select a particular number of delay segments such that the propagation of a first edge transition (102) through the series combination of the shorter first path (215a, 215b) and the delay segment (208) is delayed sufficiently to arrive at the second path distal end (216) within +/-.DELTA.~t? of the time of arrival of the first edge transition propagating through the second path. Multiple PCD~s? may be distributed on a PCB to compensate delay differences for multiple pairs of unequal length bifurcated clock/signal lines.
Patent CA-2365780-A1 (CA)
Inventor: MAEHARA OSAMU
IPC: C12N15/00
Filed: 2000-03-06
Abstract: The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same.
Patent CA-2366551-A1 (CA)
Inventor: MOSTER JEFFREY A
IPC: A61G7/015
Filed: 2000-05-11
Abstract: A manifold and valve assembly includes a manifold block (136) having an inlet (142), an outlet (144), and a conduit in fluid communication with the inlet (142) and with the outlet (144). The assembly also includes a valve (92, 96, 94) having a portion movable within the conduit between a first position blocking fluid communication between the inlet (142) and the outlet (144) and a second position in which the inlet (142) is in fluid communication with the outlet (142), a solenoid (184) operable to move the valve (92, 96, 94) from the first position to the second position in response to an electrical input applied to the solenoid (184), and a lever (208, 210, 212) operable to move the valve (92, 96, 94) from the first position to the second position in response to a manual input applied to the lever (208, 210, 212).
Patent CA-2371041-A1 (CA)
Title: Gel purge formulations and methods of cleaning extruders by using the same
Inventor: WALDROP MARK W
IPC: B29C48/27
Filed: 2002-02-06
Abstract: Methods for cleaning screw extruder, especially powder-coating extruders, include filling the extruder barrel with a gel purge formulation comprised of a high-boiling pyrrolidone or piperidone (lactam) solvent (most preferably N-methyl pyrrolidone (NMP)), thickened with 5-50 wt.% of a thermoplastic resin thickening agent, most preferably polystyrene (PS). Once the extruder barrel is filled with the gel purge formulation, the screws are stopped and the gel allowed to soak for between about 10 to about 30 minutes. The screws are then restarted and the gel is discharged from the extruder. Immediately after the gel purge formulation exits the machine, a small amount of a thermoplastic "rinse" polymer (e.g., polyethylene) may be added so as to remove any vestigial amount of the gel purge formulation therefrom.
Patent CA-2371689-A1 (CA)
Inventor: FLEISCHER WOLFGANG
IPC: A61P31/04
Filed: 2000-05-25
Abstract: A pharmaceutical preparation for functional and cosmetic tissue remodelling and repair treatments of wounds of the external and internal parts of the human or animal body, comprising antiseptic agents, wherein the preparation contains at least one of said agents combined with a particulate carrier.
Patent CA-2372409-A1 (CA)
Title: Delivery of macromolecules into cells
Inventor: WALTERS RICHARD E
IPC: A61P43/00
Filed: 2000-01-12
Abstract: An object of the invention is to provide a method for delivery of macromolecules into biological cells, such as Langerhans cells (22) in the epidermis (20) of a patient, which includes the steps of coating electodes (16) in an electrode assembly (12) with solid phase macromolecules to be delivered, such as a DNA, and/or RNA vaccine or a protein-based vaccine, attaching the electrode assembly (12) having the coated electrodes (16) to an electrode assembly holder (13), providing a waveform generator (15), establishing electrically conductive pathways between the electrodes (16), and the waveform generator (15), locating the electrodes (16) such that the biological cells are situated therebetween, such as by penetrating the needle electrode (16) into the epidermis (20) above the epidermal basal lamina, and providing pulse waveform from the waveform generator (15) to the electrodes (16), such that macromolecule on the electrodes (16) is driven off of the electrodes (16), and delivered into the biological cells, such as the Langerhans cells (22).
Patent CA-2373697-A1 (CA)
Inventor: ROSS GREGORY M
IPC: C07D221/14
Filed: 2000-05-11
Abstract: L'invention porte sur des compositions inhibant la fixation du facteur de croissance du nerf au récepteur commun de la neurotrophine, le p75?NTR¿, et sur leurs procédés d'utilisation. Dans l'une des exécutions, le composé inhibiteur comprend, particulièrement lorsqu'il est fixé au facteur de croissance du nerf, au moins deux des éléments suivants: (1) un premier atome ou groupe fonctionnel électronégatif placé de manière à interagir avec le Lys ?34¿ du facteur de croissance du nerf; (2) un deuxième atome ou groupe fonctionnel électronégatif placé de manière à interagir avec le Lys?95¿ du facteur de croissance du nerf; (3) un troisième atome ou groupe fonctionnel électronégatif placé de manière à interagir avec le Lys?88¿ du facteur de croissance du nerf; (4) un quatrième atome ou groupe fonctionnel électronégatif placé de manière à interagir avec le Lys?32¿ du facteur de croissance du nerf; et (5) un fragment hydrophobe interagissant avec la région hydrophobe formée par les Ile?31¿, Phe?101¿ et Phe?86¿ du facteur de croissance du nerf.
Patent CA-2374378-A1 (CA)
Title: Rotary particle-drying drum
Inventor: KLUG ANDREAS
IPC: F26B11/04
Filed: 2002-03-04
Abstract: A rotary particle dryer has a shaft extending along an axis and a hollow drum coaxially and spacedly surrounding the shaft and rotatable about the axis in a direction. A set of axially extending inner baffles fixed to the shaft extend radially outward therefrom and each form at least one angularly open inner pocket. A set of axially extending outer baffles fixed to the drum extend radially inward therefrom and each form at least two angularly open outer pockets. Structure mechanically connects the inner baffles directly with the outer baffles.
Patent CA-2375092-A1 (CA)
Title: Disposable sensor and method of making
Inventor: SETO FUNG
IPC: G01N27/26
Filed: 2000-05-31
Abstract: A disposable electrode strip for testing a fluid sample including a laminated strip with a first and second end, a reference electrode embedded in the laminated strip proximate to the first end, at least two working electrodes embedded in the laminated strip proximate to the first end and the reference electrode, an open path for receiving a fluid sample beginning from the first end and being sufficiently long to expose the reference electrode and the working electrodes to the fluid sample, and conductive contacts located at the second end of the laminated strip. The laminated strip has a base layer with a conductive coating, a reagent holding layer, a channel forming layer and a cover. One of the working electrodes contains a reagent substantially similar to the reagent of the reference electrode and a second working electrode contains a reagent having an enzyme.
Patent CA-2375437-A1 (CA)
Title: Illumination systems for eyeglass and facemask display systems
Inventor: SPITZER MARK B
IPC: G02F1/13357
Filed: 2000-05-30
Abstract: A display illumination and viewing system (figure 4) has an illumination optical path and a viewing optical path coinciding along a portion of their lengths. A display (60) is located at one end of the coinciding path portion . A first lens system is located on the coinciding path portion and a second lens system is located on the viewing optical path. An illumination assembly  is located on the illumination optical path and off the coinciding path portion. The illumination assembly is spaced from the first lens system by a  distance corresponding to a focal length of the first lens system. A reflective and transmissive element is located at an opposite end of the coinciding path portion to reflect light from the illumination assembly onto  the coinciding path portion toward the display and to transmit light from th e display along the viewing optical path. In another aspect of the invention, the image display system is operable in a color mode and a monochrome mode. Illumination circuitry (figures 8-11) is in communication with an illuminati on source and includes a switch operative to switch the illumination source between the color mode to provide a color display and the monochrome mode to  provide a monochrome display.
Patent CA-2376013-A1 (CA)
Title: A bag with two convex lids
Inventor: BROMS ELISABET
IPC: A45C3/00
Filed: 2000-07-07
Abstract: A bag comprising a body (3) which has a lid (1, 2) on at least one of its two mutually opposing sides, wherewith the bottom edge of the lid is hinged to the bottom part of the body, wherein the lid (1, 2), which is substantially rigid, has an outwardly arched outer surface which is adapted to lie tangentially to the underlying bag supporting surface (55) at a distance from the area in which the bag (3) is supported by said surface (55) when the lid (1, 2) has been opened out. When in contact with the underlying supporting surface, the rim of the lid pitches a plane that defines with the underlying supporting surface (55) an angle that is greater than 5~. The bag includes means (12) adapted for limiting the maximal angle to which the lid can be opened relative to the body to a value at which the lid will lie tangentially to the bag supporting surface (55).
Patent CA-2376144-A1 (CA)
Title: Fill valve
Inventor: JOHNSON DWIGHT N
IPC: E03D1/30
Filed: 1998-11-18
Abstract: A fill valve has a main valve with a valving surface contacted by a valve disk. A series of offset radial paths separated by a toroidal path permit free radial flow at full open and quiet tortuous flow as the valve closes. Removal of a cap permits access to the main valve for cleaning. Indicia in the valve body provide easy height adjustments. A riser base is made up of easily molded locking parts and provides a variable height adjustment structure that is shielded from view. A flexible cup performs multiple functions including serving as a pilot valve, a vacuum breaker valve and a seal. A float for operating the pilot valve is pivotally mounted without extra parts or fasteners.
Patent CA-2382045-A1 (CA)
Title: Hdac4 and hdac5 in the regulation of cardiac gene expression
Inventor: MCKINSEY TIMOTHY A
IPC: A61K35/76
Filed: 2000-08-21
Abstract: The present invention relates to cardiac hypertrophy. More particularly, the  present invention defines the molecular events linking calcium stimulation t o cardiac hypertrophy. More specifically, the present invention shows that Ca2 + stimulation of the hypertrophic response is mediated through an HDAC 4 and 5  interaction with MEF2, and that phosphorylation of HDACs results in loss of HDAC-mediated repression of MEF2 hypertrophic action. Thus, the present invention provides methods and compositions of treating cardiac hypertrophy,  as well as methods and compositions for identifying subjects at risk for cardiac hypertrophy. Further provided are methods for the detection of compounds having therapeutic activity toward cardiac hypertrophy.
Patent CA-2382447-A1 (CA)
Inventor: ELIAS PETER
IPC: A01B1/00
Filed: 2002-03-12
Abstract: A manual garden tool comprised of a shaft having a cental axis of rotation, and two ends. A removable, height-adjustable handle located at one end of said shaft and a garden tool located at the opposite end of said shaft. Said tool having a narrow cultivating/cutting blade that rotates around a stabilizing rod. Said blade is sharpened front and back of the lengthwise edges of all four cutting edges of the blade. The cultivating/cutting blade has a propeller like design that propels the tool downward into the ground when the tool is inserted into the ground using a slight downward pressure, and is turned in a forward and backward motion of operation of the garden tool. The said cultivating/cutting blade cuts through and destroys weeds during both 'the forward and the backward motion of operation of the said tool, cutting and destroying weeds both at and below the surface of the soil. The sharpened, narrow cultivating/cutting blade also has a slight angle; angling downwards, from the stabilizing rod, towards the edges furthest from said stabilizing rod. The said tool also has a centrally located rod that has a central axis of rotation, i.e. stabilizing rod'. The sharpened, narrow cultivating/cutting blade also has four digger/cutter rods attached by welding to the blade 2'/Z' long and angled down from the narrow, cultivating/cutting blade and then angled approximately 25° forward from stabilizing rod in a clockwise rotation of garden tool.      These four said rods are sharpened on all sides at the ground engaging ends of said rods. This mufti-sharpened rod feature increases the efficiency of the garden tool by allowing the said rods to cut through and destroy weeds during both the forward and the backward motion of operation of the garden tool. An additional feature of these four rods is their ability to breakup and aerate the soil. The combined features of the mufti-sharpened edges and the angling of the cultivating/cutting blade and of the digger/cutter rods intrinsically result in a garden tool that is extremely effective while requiring very little effort to operate.     Due to the design of said narrow cultivating/cutting blade, said garden tool is able, by cutting through their roots, to destroy weeds growing in dense conditions, very close to other plants/flowers, and by using a forward and backward semi-circular motion with the garden tool, weeds are destroyed without fear of damage to roots of adjacent flowers/plants.
Patent CA-2386767-A1 (CA)
Inventor: DONOHO GREGORY
IPC: A61K48/00
Filed: 2000-09-22
Abstract: L'invention concerne de nouvelles séquences polynucléotidiques et polypeptidiques humaines qui peuvent être utilisées dans des applications thérapeutiques, diagnostiques et pharmacogénomiques.
Patent CA-2386912-A1 (CA)
Title: Dosage unit for dry powder medicament
Inventor: BRAITHWAITE PHILIP
IPC: A61M13/00
Filed: 2000-10-20
Abstract: There is described a medicament dosage unit (1) comprising a sleeve (12) and a medicament holding chamber (2) adapted to form a slidable fit within the sleeve (12), the sleeve (12) and the chamber (2) being dimensioned such that the sleeve (12) extends beyond the length of the chamber (2), and the unit being provided with an openable closure member (6). There is also described a cartridge comprising (112) a plurality of such dosage units and a delivery device adpated for the use of individual dosage units of a cartridge.
Patent CA-2388890-A1 (CA)
Title: Hermetically sealing enclosure for housing photo-semiconductor devices and photo-semiconductor module incorporating the enclosure
Inventor: TATOH NOBUYOSHI
IPC: H01S5/022
Filed: 2002-06-04
Abstract: A hermetically sealing enclosure for housing photo-semiconductor devices that reduces the heat generated in the wiring strips at the ceramic terminal mem-ber, increases the allowable current of the wiring strips in comparison with the conventional enclosures while maintaining the low power consumption, and stabilizes the output of the device in the enclosure. A photo-semiconductor module incorporating the enclosure is also offered. The ceramic terminal mem-ber is provided with a first wiring layer that comprises a plurality of wiring strips and that penetrates through the ceramic terminal member; two second wiring layers each of which comprises at least one wiring strip, one of which is connected to the first wiring layer at the outside of the enclosure, and the other of which is connected to the first wiring layer at the inside; and at least one third wiring layer that comprises at least one wiring strip and that connects the two second wiring layers.
Patent CA-2397009-A1 (CA)
Title: Directional audio signal processing using an oversampled filterbank
Inventor: BRENNAN ROBERT L
IPC: H04R3/00
Filed: 2002-08-07
Abstract: A directional signal processing system for beamforming information signals. The system includes an oversampled filterbank, which has an analysis filterbank for transforming the information signals in time domain into channel signals in transform domain, a synthesis filterbank and a signal processor. The signal processor processes the outputs of the analysis filterbank for beamforming the information signals. The synthesis filterbank transforms the outputs of the signal processor to a single information signal in time domain.
Patent CA-2399336-A1 (CA)
Title: Continuous hot rolling method
Inventor: TAMURA NOZOMU
IPC: B21B15/00
Filed: 1994-06-15
Abstract: The invention comprises a continuous hot rolling method in which a rear end portion of a preceding metal block and a fore end portion of a succeeding metal block are cut and the metal blocks are joined to each other by heating and pressing followed by a finish rolling. The joined portion is cooled before or after removal of the poor joined portion. Cooling may be effected by a cooling nodule that applies a cooling medium at the location where the poor joined portion is removed.
Patent CA-2399634-A1 (CA)
Inventor: ODDON GILLES
IPC: C07H17/08
Filed: 2001-03-23
Abstract: The invention concerns a method for preparing 9-deoxo-8a-aza-(8a-alkyl)-8a- homoerythromycin A and its 8a-alkyl derivatives from 9-deoxo-9(Z)- hydroxyiminoerythromycin A via a Beckmann stereospecific rearrangement in a reaction medium using pyridine as main solvent, leading to imidate intermediates which are not isolated from said medium and which are directly  engaged in a reduction step using a sufficient amount of borohydride, after extracting the pyridine with a hydrocarbon miscible therewith and wherein sa id imidates are insoluble. The compound (V) can be directly N-alkylated in position-8a, using an aldehyde, without being isolated from the reduction medium.
Patent CA-2404310-A1 (CA)
Title: A p-selectin glycoprotein ligand (psgl-1) binding protein and uses therefor
Inventor: KRIZ RON
IPC: C12Q1/6883
Filed: 2001-03-23
Abstract: The invention provides isolated nucleic acid molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic ac id molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced , and nonhuman trangenic animals in which a SLIC-1 gene has been introduced or  disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Patent CA-2404456-A1 (CA)
Inventor: BAWA RAJAN
IPC: F26B5/06
Filed: 2001-03-27
Abstract: The present invention provides a cover plate that covers one or more delivery containers (e.g., syringe) during lyophilization. The cover plate includes a lid region and one or more protuberances which project perpendicularly from the lid re-gion. The one or more protuberances are adapted to fit in the one or more delivery containers. The cover plate permits the escape of vapor from the one or more delivery containers during the lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during the lyophilization process. The present invention also provides a system and a method for lyophilizing a solution that contains a pharmaceutical.
Patent CA-2407903-A1 (CA)
Title: Systems for determining optimal test order for disease diagnosis
Inventor: VANDEZANDE KIRK
IPC: G16B40/20
Filed: 2002-10-11
Abstract: A method for determining the optimal test order for diagnosing mutations in DNA that relate to a disease. The method includes receiving data, creating a database, receiving new data, applying a match pattern, and generating a recommendation. The method may also determine the projected costs and the projected times to perform each test in the optimal test order. A computer readable medium for determining an optimal test order for diagnosing mutations in DNA that relate to a disease. A computer system for determining an optimal test order for diagnosing mutations in DNA that relate to a disease. The system includes a computing environment, an input device, an output device, and a plurality of decision tree algorithms. The system may also determine the projected costs and the projected times to perform each test in the optimal test order.
Patent CA-2408143-A1 (CA)
Inventor: PICKERING LEE
IPC: C12Q1/6844
Filed: 2001-05-31
Abstract: L'invention porte: sur des nucléotides comportant un fragment reporter et un fragment de blocage d'une polymérase dans lesquels le fragment reporter n'agit pas seulement comme fragment de blocage d'une polymérase; et sur des composés de formule (I) dans laquelle: W est un groupe phosphate; B est une base; Y est un liant comprenant un groupe clivable par une enzyme; R?2¿ est un fragment reporter; R?3¿ est choisi parmi H ou OH; Z et Z' sont choisis parmi H, OH, ou un groupe X-R?1¿, dans lequel X est un liant comprenant un groupe clivable par une enzyme; et R?1¿ est un groupe de blocage de la polymérase sous réserve que l'un de Z et Z' soit X- R?1¿.
Patent CA-2410668-A1 (CA)
Inventor: JERMANN FRANK
IPC: H01J63/04
Filed: 2001-05-11
Abstract: The inventive white-light emitting luminescent conversion LED uses a chlorosilicate luminous substance which is doped with europium in addition to containing Ca and Mg and a garnet rare-earth substance, especially Y and/or Tb. This results in high quality colour reproduction and highly constant lighting properties at various temperatures.
Patent CA-2411635-A1 (CA)
Title: Track system for mobile storage apparatus
Inventor: GILBERT GEORGE GLEN
IPC: A47B53/02
Filed: 2002-11-08
Abstract: The invention provides longitudinally extending track support and track members for a mobile storage unit. The track support's upper surface has at least one protrusion which projects above and extends longitudinally along that upper surface. A mating recess extends within and along the track member's under surface. The recess and protrusion are sized and shaped for loose-fit longitudinal engagement of the protru- sion within the recess when the track member is laid atop the track support. This permits limited transverse movement of the track member with respect to the track support, reducing susceptibility of the mobile storage unit's wheels to derailment if a transverse force is applied to mobile storage unit as it rolls along the track.