baber/WOPTO huggingface dataset:
Patent CY-1115069-T1 (CY)
Title: Εκλεκτικος ρυθμιστης οιστρογονικου υποδοχεα σε συνδυασμο με δεϋδροεπιανδροστερονη (dhea) ή αναλογα
Inventor: LABRIE FERNAND
IPC: A61K31/56
Filed: 2014-05-09
Abstract: Νέες μέθοδοι για την ιατρική αντιμετώπιση και/ή παρεμπόδιση της ανάπτυξης καρκίνου του μαστού, υπερχοληστερολαιμίας, υπερλιπιδαιμίας ή αθηροσκλήρωσης σε ευπαθή θερμόαιμα ζώα περιλαμβάνοντας ανθρώπους οι οποίες αφορούν χορήγηση εκλεκτικού ρυθμιστή οιστρογονικού υποδοχέα και μιας ποσότητας μιας πρόδρομης ένωσης στεροειδούς του φύλου επιλεγμένης από την ομάδα η οποία αποτελείται από δεϋδροεπιανδροστερόνη, θειική δεϋδροεπιανδροστερόνη, ανδροστ-5-ενο-3β-17β-διόλη και ενώσεις οι οποίες μετατρέπονται in vivo σε μία από τις προαναφερθείσες πρόδρομες ενώσεις. Η περαιτέρω χορήγηση διφωσφονικών σε συνδυασμό με εκλεκτικούς ρυθμιστές οιστρογονικού υποδοχέα και/ή πρόδρομες ενώσεις στεροειδούς του φύλου γνωστοποιείται. Φαρμακευτικές συνθέσεις για παροχή δραστικών συστατικών και κυτία χρήσιμα για την εφεύρεση γνωστοποιούνται.
Patent CY-1115251-T1 (CY)
Title: Θεραπεια λευχαιμιας ανθεκτικης σε ιματινιμπη χρησιμοποιωντας 4-αμινοκινολινο-3-καρβονιτριλια
Inventor: HEWES BECKER
IPC: A61P35/02
Filed: 2014-06-03
Abstract: Η παρούσα εφεύρεση παρέχει ενώσεις 4-αμινοκινολινο-3-καρβονιτριλίου χρήσιμες για θεραπεία ενός υποκειμένου που έχει θετική σε BcrAbl λευχαιμία που είναι ανθεκτική σε ιματινίμπη.
Patent CY-1116719-T1 (CY)
Title: Μεθοδοι ανιχνευσης αντισωματων αντι-φαρμακου
Inventor: PARUSSINI ERMIS
IPC: G01N33/68
Filed: 2015-09-22
Abstract: Η παρούσα εφεύρεση σχετίζεται με μεθόδους ανίχνευσης αντισωμάτων αντι-φαρμάκου. Η παρούσα εφεύρεση σχετίζεται επίσης με μεθόδους παρακολούθησης ασθενών που υποβάλλονται σε αγωγή θεραπευτικού αντισώματος. Η εφεύρεση σχετίζεται επιπλέον με κιτ κατάλληλα για την εφαρμογή των ανωτέρω μεθόδων.
Patent CY-1117063-T1 (CY)
Title: Μεθοδος για τη θεραπεια του καρκινου με ανταγωνιστη toy dll4 και χημειοθεραπευτικο παραγοντα
Inventor: NOGUERA-TROISE IRENE
IPC: C07K16/22
Filed: 2015-12-22
Abstract: Η εφεύρεση παρέχει μεθόδους για τη θεραπεία διαφόρων τύπων καρκίνου/όγκου με χορήγηση του συνδυασμού ανταγωνιστών του D114, ιδίως αντισωμάτων κατά του D114 και θραυσμάτων αυτών που δεσμεύουν ειδικά τον ανθρώπινο D114, και χημειοθεραπευτικών παραγόντων. Αυτές οι συνδυαστικές θεραπείες παρουσιάζουν συνεργιστικά αποτελέσματα σε σύγκριση με την θεραπευτική αγωγή με μόνο έναν από τους δύο παράγοντες. Συνεπώς, οι μέθοδοι της εφεύρεσης είναι ιδιαίτερα ευεργετικές για τους καρκινοπαθείς που έχουν χαμηλή ανοχή στις παρενέργειες που προκαλούνται από τις υψηλές δόσεις που απαιτούνται για τη θεραπεία με μόνο έναν από τους δύο παράγοντες, καθώς παρέχουν τη δυνατότητα μείωσης των αποτελεσματικών δόσεων. Παρέχονται επίσης φαρμακευτικές συνθέσεις και κιτ που περιέχουν ανταγωνιστές του D114 και χημειοθεραπευτικούς παράγοντες.
Patent CY-1119588-T1 (CY)
Title: Εκλεκτικοι αναστολεις pi3κ δελτα
Inventor: VAKKALANKA SWAROOP KUMAR VENKATA SATYA
IPC: C07D487/04
Filed: 2017-11-10
Abstract: Η παρούσα εφεύρεση αφορά εκλεκτικούς αναστολείς ΡΙ3Κ δέλτα πρωτεϊνικών κινασών που έχουν ένα σύστημα δακτυλίου 1Η-πυραζολο[3,4-d]πυριμιδίνης, μεθόδους παρασκευής αυτών, φαρμακευτικές συνθέσεις που περιέχουν αυτούς και μεθόδους θεραπείας και/ή πρόληψης των μεσολαβούμενων δια των κινασών νόσων ή διαταραχών με αυτούς.
Patent CY-1120622-T1 (CY)
Title: Μεθοδοι και συνθεσεις για επαγωγη μιας ανοσιακης αποκρισης ως προς egfrviii
Inventor: LAUER PETER M
IPC: C12N15/00
Filed: 2018-08-27
Abstract: Η παρούσα εφεύρεση σχετίζεται με μεθόδους επαγωγής μιας απόκρισης κυττάρων Τ έναντι ενός EGFRvIII σε ένα υποκείμενο. Αυτές οι μέθοδοι περιλαμβάνουν χορήγηση σε ένα υποκείμενο μιας σύνθεσης η οποία εκφράζει τουλάχιστον ένα ανοσογόνο πολυπεπτίδιο, η αλληλουχία αμινοξέων του οποίου περιλαμβάνει μια πλειάδα αλληλουχιών πολυπεπτιδίων του EGFRvIII, η αλληλουχία του οποίου περιλαμβάνει κάθε μια EEKKGNYV (ΑΛΛΗΛΟΥΧΙΑ ΑΡ. ΤΑΥΤΟΤΗΤΑΣ: 3), και/ή χορήγηση αυτού του ίδιου του πολυπεπτιδίου.
Patent CY-1121493-T1 (CY)
Title: Ελεγχος συστηματος εκλουσης ρουβιδιου
Inventor: DEKEMP ROBERT A
IPC: A61M5/00
Filed: 2018-11-15
Abstract: Μια μέθοδος ελέγχου ενός συστήματος έκλουσης 82Sr/82Rb που έχει μια βαλβίδα συσκευής παραγωγής για τη δοσολογία μιας ροής αλατούχου διαλύματος μεταξύ μιας συσκευής παραγωγής 82Sr/82Rb και μιας γραμμής παράκαμψης που είναι συζευγμένη με μια έξοδο της συσκευής παραγωγής έτσι ώστε το αλατούχο διάλυμα που διασχίζει τη γραμμή παράκαμψης να συγχωνεύεται με εκλουόμενο αλατούχο διάλυμα που αναδύεται από τη συσκευή παραγωγής για να παρέχει ένα ενεργό αλατούχο διάλυμα. Κατά τη διάρκεια κάθε διαδικασίας έκλουσης, λαμβάνεται ένα πλήθος διαδοχικών τιμών παραμέτρων συγκέντρωσης σε προκαθορισμένα διαστήματα. Κάθε τιμή παραμέτρου συγκέντρωσης είναι ενδεικτική μιας αντίστοιχης στιγμιαίας συγκέντρωσης ενεργότητας του ενεργού αλατούχου διαλύματος. Υπολογίζονται οι αντίστοιχες τιμές σφάλματος μεταξύ κάθε τιμής παραμέτρου συγκέντρωσης και μιας στοχευόμενης τιμής συγκέντρωσης ενεργότητας της διαδικασίας έκλουσης. Τα δεδομένα σφάλματος που βασίζονται σε ένα πλήθος υπολογισμένων τιμών σφάλματος συσσωρεύονται. Μεταξύ διαδοχικών εκτελέσεων έκλουσης, τουλάχιστον μία παράμετρος απόδοσης του συστήματος έκλουσης ρυθμίζεται με βάση τα συσσωρευμένα δεδομένα σφάλματος.
Patent CY-1125071-T1 (CY)
Title: Θεραπεια του συνδρομου ευθραυστου χ με κανναβιδιολη
Inventor: BONN-MILLER MARCEL
IPC: A61K31/05
Filed: 2022-02-22
Abstract: Η τεχνολογία της παρούσας σχετίζεται με μια μέθοδο θεραπείας ενός ή περισσότερων συμπεριφορικών συμπτωμάτων του Συνδρόμου Εύθραυστου Χ σε ένα άτομο, με διαδερμική χορήγηση μιας αποτελεσματικής ποσότητας κανναβιδιόλης (CBD)στο άτομο, όπου ένα ή περισσότερα συμπεριφορικά συμπτώματα του Συνδρόμου Εύθραυστου Χ θεραπεύονται στο άτομο.
Patent HR-P20090684-T1 (HR)
Title: Conditioned blood composition and method for its production
Inventor: REINECKE JULIO
IPC: A61P37/00
Filed: 2009-12-23
Abstract: Preparing a conditioned blood composition from blood, comprises withdrawing blood from a human or animal body; incubating the blood in a modified container with internal surface at 10-40[deg]C for conditioning of the blood, where the factors are induced, and the modified container exhibits an internal surface of at least 100 mm 2> per 1 ml of incubating blood (surface index); and obtaining a conditioned blood composition with induced factors in the modified container. An independent claim is included for a blood composition, obtained by the above method, for treating or preventing of sufferings of the human or animal body comprising 30-20000 pg/ml of interleukin(IL)-6. ACTIVITY : Muscular-Gen; Antiallergic; Immunomodulator; Antipsoriatic; Antidiabetic; Antiulcer; CNS-Gen; Anabolic; Vulnerary. MECHANISM OF ACTION : None given.
Patent HR-P20100712-T1 (HR)
Title: Device used to open and close vasistas windows
Inventor: CIRILLI ALESSANDRO
IPC: E05F11/04
Filed: 2010-12-21
Abstract: The present invention relates to a device used to open and close Vasistas windows, which is actuated by means of a single rope (2), in which the lock (S) comprises an oscillating plate (4) for coupling with the pin (1), which interferes with a retention catch (6) actuated by the opening lever (7) by means of a flexible blade (8) that interferes with a cam (4e) obtained on the oscillating plate (4).
Patent SI-1407006-T1 (SI)
Title: Method for the recovery and purification of poxviruses from infected cells
Inventor: HELLER KARL
IPC: C12N15/00
Filed: 2002-12-13
Abstract: The present invention relates to a method for the recovery of poxviruses, in particular modified Vaccinia virus Ankara (MVA), from infected cells. According to the present invention the virus-infected cells are subjected to a high-pressure homogenization to obtain a virus containing homogenate. The virus containing homogenate can be subjected to at least one purification step to obtain apoxvirus-enriched fraction. The invention further relates to the virus containing fraction and the virus containing homogenate obtained by the method according to the present invention.
Patent SI-1564351-T1 (SI)
Title: Fencing section with flat rod panels fixed to fencing post
Inventor: VANDERBRUGGHEN STEFAAN
IPC: E04H17/16
Filed: 2004-02-13
Abstract: A fencing section (30) comprises at least one flat rod panel (32, 34), a fencing post (36) with the panel (32, 34) fixed to the fencing post (36). The rod panel (32, 34) has vertically extending rods (40, 43, 44) and horizontally extending rods (38). The vertically extending rods (40) are welded to the horizontally extending rods (38). The vertically extending rods (40) facing the fencing post (36). The fencing post (36) has an open side having an openness (42) which is open over at least the height of the vertically extending rods (40). The open side face the rod panel (32, 34). The open side has two flange portions (41) which limit the openness (42). The rod panel (32, 34) is fixed to the fencing post (36) so that at least one vertically extending rod (43, 44) is housed in the openness (42). <IMAGE>
Patent SI-1701978-T1 (SI)
Title: Use of soluble T-Cadherin for the treatment of metabolic disorders
Inventor: HUG CHRISTOPHER
IPC: G01N33/00
Filed: 2004-12-02
Abstract: This invention relates to the use of T-cadherin polypeptides for screening for modulators thereof, and to the use of said modulators for treating disorders selected from the group consisting of a metabolic disorder, a gynecologic disorder, a chronic inflammatory disorder and a liver or renal disorder. Metabolic disorders that may be treated using a modulator according to the present invention include, e.g., obesity, type II diabetes, insulin resistance, hypercholesterolemia, hyperlipidemia, dyslipidemia, syndrome X, cachexia and anorexia.
Patent SI-2380584-T1 (SI)
Title: Immunostimulatory method
Inventor: LOFBERG ROBERT
IPC: A61K31/00
Filed: 2006-06-29
Abstract: The present invention makes it possible to enhance steroid efficacy in a steroid dependent patient afflicted with an inflammatory condition by administering an oligonucleotide having the sequence 5'-GGAACAGTTCGTCCATGGC-3' in an effective amount. The invention also encompasses the use of said oligonucleotide for the manufacture of pharmaceuticals.
Patent SI-2134607-T1 (SI)
Title: Rigid container for food including fish
Inventor: RONSIN BENOIT
IPC: B65B25/00
Filed: 2008-12-04
Abstract: The container (10) has a receptacle (14) with a disk shape base (18) and smooth side walls (20), where the container is made of a plastic material or steel. The diameter of the base is between 60 and 110 millimeter. A cover (16) is mounted on the receptacle of the container, where the container is filled with gas (22) e.g. nitrogen in gaseous form and water in gaseous form, using an introducing unit. Independent claims are also included for the following: (1) a method for realizing a container (2) a device for realizing a container.
Patent TR-200301287-T1 (TR)
Title: Siselenmis su bosaltim cihazi
Inventor: LEE YEON SEOK
IPC: B67D3/00
Filed: 2002-11-09
Abstract: Burada bir sislenmis su bosaltim düzenegi ifsa edilmektedir. Siselenmis su bosaltim düzenegi, bir su sisesi destegi, ambalaj kapagi ve bir manifold içerir. Su sisesi destegi bir su sisesinin agzina konur ve bir sterilize etme aracina, bir hava dolum borusuna, bir su çikisina sahip bir kapak elemanina, bir kapatma elemanina ve bir elastik elemana sahiptir. Huni seklindeki ambalaj kapagi, su sisesi üzerine konan su sisesi destegine yer tedarik etmek için bir siselenmis su dagiticisinin agzina konur ve ucuna siselenmis su dagiticisinin agzi tarafindan tutulmak üzere bir flans yerlestirilir. Bu flans bir ambalaj kapagiyla entegredir. Manifold sicak ve soguk su haznesine baglanmak için ambalaj kapaginin tabaninin merkezine siki sekilde yerlestirilir. Manifold, su sisesi desteginin kapatma elemanini yukari kaldirmak ve su sisesi desteginin su çikisini açmak için ambalaj kapaginin tabanindan yukari dogru uzatilir.
Patent TR-200402587-T1 (TR)
Title: Optik emniyet bileşeni
Inventor: SOPARIS HUGUES
IPC: G02B1/00
Filed: 2003-03-21
Abstract: Bu bulus bir belgenin veya bir ürünün gerçekligini dogrulamak için bir optik emniyet bilesenine iliskindir; bu bilesen en azindan bir difraksiyon yapan sebeke sergilemek üzere kabartilmis bir saydama plastik film (11) içerir; kabartilmis yüzey (3),en azindan kismen yüksek optik indisli dielektrik malzeme tabakasi (4) ile kaplanir; bu yüzey, bilesenin birinci yönü için birinci renkten, birinci yöne için birinci renkte, birinci yöne dik bir yön için farkli ikinci bir renkten olusan bir renkli etki üretir; bilesenin özelligi,tabakanin (4=, gözlemlenme yönüne karsit tarafta düsük optik indisli bir tabaka (5) ile ardindan saydam sahalar ve renkli sahalar içeren bir renkli kontrast tabakasi (2) ile kaplanmasidir.
Patent TR-200600834-T1 (TR)
Inventor: ACIKGOEZ HARUN
IPC: H02K1/30
Filed: 2004-07-12
Abstract: This invention is related to a motor (20), which operates at a desired number of torque and revolution by changing the quantity and the position of the stator segments (31).
Patent TR-200901109-T1 (TR)
Inventor: REED STEVEN G
IPC: C12Q1/68
Filed: 1996-08-30
Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M tuberculosis infection, or may be used for the diagnosis of tuberculosis.
Patent TR-201605860-T1 (TR)
Title: Metal oksi̇t kenetli̇ grafen ve karbon nanotüp i̇çeren hi̇bri̇d köpük.
Inventor: WEI WANG
IPC: C01G47/00
Filed: 2013-11-05
Abstract: Bir metal oksit kenetli grafen ve karbon nanotüp hibrid köpük (10, 20) bir iki adımlı proses ile oluşturulabilir. Yöntem (100), en az bir grafen katmanının (14, 24) ve çok sayıda karbon nanotübün (16, 30), bir kaplanmış gözenekli metal substrat (12, 22) oluşturacak şekilde, kimyasal buharlı çökeltim yoluyla bir gözenekli metal substratın (12, 22) bir yüzeyi (13, 26) üzerinde oluşturulmasını, ve çok sayıda metal oksit nanoyapının, metal oksit kenetli grafen ve karbon nanotüp hibrid köpük (10, 20) oluşturacak şekilde, kaplanmış gözenekli metal substratın (12, 22) bir yüzeyinde (13, 26) çökeltilmesini içerebilir.
Patent TR-201809321-T1 (TR)
Title: Elektrolitik kaplama boyasına yönelik akrilik kopolimeri ve bunun üretim metodu.
Inventor: DA EUN JEONG
IPC: C09D5/44
Filed: 2016-12-29
Abstract: Mevcut buluş, bir elektrolitik kaplama boyasına yönelik bir akrilik kopolimeri ve bunun bir üretim metodu ile ilgilidir ve daha fazla özellikle, çukurları önleyebilen ve bir elektrolitik kaplama boyasına yönelik kullanıldığında kirleticiler nedeniyle görünüm bozulmasına karşı direnci geliştirerek kaplanmış bir tabakanın görünüm kalitesini arttırabilen bir akrilik kopolimer ve bunun bir üretim metodu ile ilgilidir.
Patent DE-3686642-T2 (DE)
Inventor: OHTA TOSHIRO
IPC: G11B25/10
Filed: 1986-12-23
Granted: 1993-03-11
Abstract: A magnetic tape cartridge (10) compatible with a disc drive is provided with a tape guide (400) for accurately positioning a magnetic tape (12) in relation to a disc drive head (502, 504). The tape guide (400) includes a positioning section to be aligned with a rotational axis of a centre core assembly (200) when the centre core assembly (200) is chucked on a turntable (302) of the disc drive. The tape guide (400) also includes a guide section (412, 414a) defining a tape run path across the disc drive head (502, 504). The guide section (412, 414a) is formed integrally with the section to be aligned with the centre core assembly (200) and is so distanced therefrom as accurately to position the tape (12) with respect to the disc drive head (502, 504), so the distance therebetween can be maintained precisely constant.
Patent DE-3782566-T2 (DE)
Inventor: FEDERSEL HANS-JUERGEN
IPC: C07D207/00
Filed: 1987-05-19
Granted: 1993-03-25
Abstract: Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity <CHEM> wherein R<1> is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is O-3 and Ph is a substituted or unsubstituted phenyl group including     l) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline   2) aminolysis 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R<2> is defined as R<1> above.   <CHEM> h
Patent DE-3874816-T2 (DE)
Inventor: BITHA PANAYOTA
IPC: C07F15/00
Filed: 1988-04-09
Granted: 1993-03-25
Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
Patent DE-3875580-T2 (DE)
Inventor: KETCHAM THOMAS DALE
IPC: C04B35/48
Filed: 1988-09-14
Granted: 1993-05-13
Abstract: This invention is concerned with a hard, tough, thermally conductive ceramic cutting tool insert consisting essentially of a zirconia alloy in a hard refractory ceramic insert and the product thereof. The ceramic cutting tool insert exhibits performance conducive to use in turning operations and/or milling operations. In particular the invention provides a ceramic cutting tool insert exhibiting a hardness greater than 15 GPa, a toughness greater than 6 MPa 2ROOT m, and a thermal conductivity greater than 14 Wm<-><1><0>K<-><1> consisting essentially, expressed in terms of percent by weight, of 20-45% zirconia alloy and 55-80% hard refractory ceramic matrix, said alloy consisting essentially, expressed in terms of mole percent on the oxide basis, of 1-4% of a toughening agent selected from the group consisting of YNbO4, YTaO4, MNbO4, MTaO4, and mixtures thereof, wherein M consists of a cation which replaces a Y cation on a mole basis selected from the group consisting of Mg<+><2>, Ca<+><2>, Sc<+><3>, and a rare earth metal ion selected from the group consisting of La<+><3>, Ce<+><4>, Ce<+><3>, Pr<+><3>, Nd<+><3>, Sm<+><3>, Eu<+><3>, Gd<+><3>, Tb<+><3>, Dy<+><3>, Ho<+><3>, Er<+><3>, Tm<+><3>, Yb<+><3>, Lu<+><3>, and mixtures thereof, and the remainder zirconia.
Patent DE-3884588-T2 (DE)
Inventor: MODARRESSE FRANCOIS SOCIETE CI
IPC: H04N11/04
Filed: 1988-12-19
Granted: 1994-04-07
Abstract: Device for data rate regulation linked to at least two digital video signal components, having a correlation reduction circuit, a scanning conversion circuit (30), a normalization circuit (40), a circuit (50) for quantification by conversion into an integral value, a circuit for encoding the quantified values, and a data rate regulation circuit, characterized in that the normalization circuit itself includes (a) a circuit (401) for the computation of the ratio rap(acti) between the activity of a first component and the activity of a second component; (b) a circuit (402) for the computation, based on rap(acti), of the ratio rap(norm) between the data rate regulation norm relating to the second component and that relating to the first component; (c) a circuit (404) for the computation of the specific norms relating respectively to the first component and to the second component, receiving, on the one hand, the said value of rap(norm) and, on the other hand, a global norm value delivered by a global norm computation circuit (406); (d) a divider (405); (e) a counter (407); (f) an auxiliary memory (408); (g) a subtractor (409); (h) the global norm computation circuit (406).
Patent DE-3887426-T2 (DE)
Inventor: NAKAJIMA YOSHIKAGE
IPC: A61K31/445
Filed: 1988-09-13
Granted: 1994-05-11
Abstract: 4 min -ethyl-2-methyl-3-piperidinopropiophenone or a pharmacologically acceptable salt thereof is useful as a hypotensive agent.
Patent DE-3887956-T2 (DE)
Inventor: PROCTOR BRIAN TERRY WESTHOLME
IPC: H01R13/658
Filed: 1988-09-29
Granted: 1994-10-06
Abstract: An arrangement for termination of a screened cable comprises:   (a) a termination piece for the screen having a hollow, preferably metal, cable entry portion that can be positioned around the wire(s) of the cable, and (b) a dimensionally recoverable hollow article which can be positioned over at least part of the cable entry portion and the proximal part of the cable extending from the cable entry portion.   The cable entry portion is provided with a gripping member, for example a thin annular ridge, for gripping the cable screen, placed around the entry portion. After the cable screen has been positioned over the cable entry portion and gripping member, the recoverable article is positioned over the cable and cable entry portion and is recovered to cause the gripping member to grip the cable screen.
Patent DE-3889867-T2 (DE)
Inventor: TIPPS BARNEY A
IPC: B42B5/08
Filed: 1988-10-28
Granted: 1994-09-29
Abstract: For convenient packaging of plastic bookbinding strips (21), cassettes are provided. The end edges of each strip are received in channels formed in opposed side rails (31). The rails engage adjacent either end the depending legs of transverse spacer bars. The spacer bars have plural sockets to engage projections on the upper ends of the legs so that the spacing between side rails may be varied to accommodate strips of different lengths - e.g., 8 1/2 inches, 11 inches, etc. Different length legs may be used to accommodate different length studs formed on the strips. By eliminating the legs entirely, flat female binding strips may be packaged in the cassette. A detent (67) is provided in the ends of the rails preventing removal of strips until the detent is bent out of position. The cassette is especially useful in equipment which mechanically assembles punched sheets and strips preparatory to binding a book in a binding machine.
Patent TR-199903281-T2 (TR)
Inventor: BROADHURST MICHAEL JOHN
IPC: C07D233/76
Filed: 1998-06-18
Abstract: Hydrazine derivatives of the formulawherein Y is CO or SO2; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl or aryl when Y is SO2 and is lower alkyl, halo-lower alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, lower cycloalkyl, aryl, aryl-lower alkyl, aryl-lower alkoxy or NR5R6 when Y is CO; and R3 is hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl or heterocyclyl; or R2 and R3 together form the residue of a 5-, 6- or 7-membered cyclic amide, cyclic imide, cyclic sulphonamide or cyclic urethane group; R4 is lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a group of the formula X-aryl, X-heteroaryl or -(CH2)1-2-CH=CR7R8; X is a spacer group; R5 and R6 each individually are hydrogen, lower alkyl or aryl-lower alkyl; and R7 and R8 together represent a lower alkylene group in which one methylene group is optionally replaced by a hetero atom; and their pharmaceutically acceptable salts inhibit not only the release of tumour necrosis factor (TNF-alpha) and transforming growth factor (TGF-alpha) from cells, but also keratinocyte proliferation. They are useful as medicaments, especially for the treatment of inflammation, fever, hemorrhage, sepsis, rheumatoid arthritis, osteoarthritis, multiple sclerosis or psoriasis.