Patent SG-11201803796S-A (SG)
Title: Indolin-2-one derivatives
Inventor: GAUFRETEAU DELPHINE
IPC: C07D403/14
Filed: 2016-11-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DEEM 1111111111111111111111111 IIII RID IIII (54) Title: INDOLIN-2-ONE DERIVATIVES (10) International Publication Number WO 2017/076852 Al WIPO I PCT (43) International Publication Date 11 May 2017 (11.05.2017) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art 21(3)) (51) International Patent Classification: C07D 401/14 (2006.01) A61K 31/44 (2006.01) CO7D 403/14 (2006.01) A61P 25/00 (2006.01) (21) International Application Number: PCT/EP2016/076332 (22) International Filing Date: 2 November 2016 (02.11.2016) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 15193342.1 6 November 2015 (06.11.2015) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant US only): HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road, 8th Floor, Little Falls, New Jersey 07424 (US). (72) Inventors: GAUFRETEAU, Delphine; 2, me du Tilleul, 68680 Kembs (FR). KOLCZEWSKI, Sabine; Minna Vortisch Strasse 12d, 79540 Loerrach (DE). PLANCHER, Jean-Marc; 9, rue des Vignes, 68220 Hagenthal-le-Bas (FR). STOLL, Theodor; Rottmannsbodenstrasse 6, 4102 Binningen (CH). HALM, Remy; 41, me de Kiffis, 68480 Lutter (FR). (74) Agent: POPPE, Regina; Grenzacherstrasse 124, 4070 Basel (CH). W O 20 17 /07 685 2 Al R 2/ N R 1 I (57) : The present invention is concerned with indolin-2-one derivatives of general formula (I) wherein the substituents are defined in claim 1. The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symp- toms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkin - son's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co- morbid epilepsy.