baber/WOPTO huggingface dataset:
Patent AU-2018238165-C1 (AU)
Title: Antibody binding specifically to MUC1 and use thereof
Inventor: MOON KYUNG DUK
IPC: C12N15/113
Filed: 2018-03-21
Granted: 2021-03-18
Abstract: The present invention relates to an anti-MUC1 antibody binding specifically to Mucin 1 (MUC1) and a use thereof and, more particularly, to an anti-MUC1 antibody or an antigen-binding fragment thereof, an antibody-drug conjugate or bispecific antibody comprising the antibody or an antigen-binding fragment thereof, a pharmaceutical composition for prevention or treatment of cancer, comprising the same conjugate or bispecific antibody, and a nucleic acid encoding the same antibody or an antigen-binding fragment thereof, a vector and a host cell, both carrying the same nucleic acid, and a method for preparing an anti-MUC1 antibody or an antigen-binding fragment thereof, using the same vector and host cell. According to the present invention, an antibody binding specifically to MUC1 or an antigen-binding fragment thereof shows outstanding affinity and binding force to MUC1 and an antibody-drug conjugate in which the antibody or an antigen-binding fragment thereof is conjugated with a drug can bind specifically to a MUC1-expressing cell to specifically or selectively transfer the drug with efficacy. Therefore, the anti-MUC1 antibody and the antibody-drug conjugate according to the present invention can be usefully applied to the treatment of a MUC1-related disease, for example, cancer.
Patent RU-2158412-C1 (RU)
Title: Method for destruction of rocks
Inventor: AKENT EV V S
IPC: F42D3/04
Filed: 2000-01-28
Granted: 2000-10-27
Abstract: FIELD: mining art, applicable in mining of ore and non-metallic mineral resources with the use of drilling and blasting operations. SUBSTANCE: the method consists in level borehole rock-breaking, multi-row lay-out of boreholes and selection of boreholes of the rock mass to be blasted in the points of intersection of diagonals of tetragons formed by "pots" from boreholes of the overlying level that are adjacent in the row and adjacent "pots" of the adjacent row. The invention is featured by a non-spontaneous selection of the lay-out of boreholes of the level to be blasted, but by their lay-out in the zone that was less of all subjected to the effect of blast of charges in the boreholes of the overlying level. EFFECT: reduced outcrop of outsize from the upper part of the rock mass of the level being mined. 2 dwg
Patent RU-2172866-C1 (RU)
Title: Sucker-rod well pump
IPC: F04B47/00
Filed: 2000-03-02
Granted: 2001-08-27
Abstract: FIELD: oil industry; oil production. SUBSTANCE: additional; discharge valve is mounted in upper portion of cylinder. Suction valve is fully flush and normally open. EFFECT: avoidance of dynamic loads of plunger and rod; reduced formation of stable emulsion in pump, additional liberation of dissolved gas and formation of foam. 2 cl, 1 dwg
Patent RU-2175658-C1 (RU)
Title: Method of preparing amaranthus starch
Inventor: KAMYSHEVA I M
IPC: C08B30/04
Filed: 2000-06-22
Granted: 2001-11-10
Abstract: FIELD: food industry, more particularly preparation of food starch from amaranthus. SUBSTANCE: method comprises steeping kernels with water to moisture content of 15-20% of weight thereof and subsequently keeping them for 4-6 h. Kernels are then dried to moisture content of 10-12 % and kernels are ground. Kernels are isolated from weight of envelope by choosing fraction with particle size of 10-100 mcm, preparing aqueous suspension from said particles and maintaining said fraction for at least 1 hour followed by centrifugation. After separating envelopes from starch, starch suspension is prepared and starch is cleaned from proteins by treatment with solutions of sodium chloride and sodium hydroxide followed by centrifugation of starch suspension. Starch is degreased and dried. Invention makes it possible to increase yield of starch and accelerate process. EFFECT: more efficient preparation method. 2 cl, 4 ex
Patent RU-2177162-C1 (RU)
Inventor: GUSEV M JU
IPC: G01R33/10
Filed: 2000-10-03
Granted: 2001-12-20
Abstract: Изобретение относится к области измерений переменных и постоянных величин магнитных полей и может быть использовано для создания на его основе магнитооптических приборов. Способ получения оптического изображения магнитного поля включает воздействие исследуемого магнитного поля на слой магнитооптического материала, размещенного на подложке, при одновременном охлаждении слоя от температуры выше температуры магнитного упорядочения до температуры ниже температуры магнитного упорядочения и получения изображения магнитной структуры пластины с помощью магнитооптического эффекта при температуре ниже температуры магнитного упорядочения. Толщину слоя магнитооптического материала выбирают не менее 0,15 мкм максимально возможной с учетом геометрического разрешения оптической системы, используемой для получения изображения, охлаждение слоя производят со скоростью не менее 2 град/с, а наблюдение осуществляют при температуре не менее чем на 3 град ниже температуры магнитного упорядочения. Обеспечено увеличение чувствительности к воздействию слабого магнитного поля путем сужения диапазона существования суперпарамагнитного состояния. 2 з.п. ф-лы.
Patent RU-2184851-C1 (RU)
Title: Method of dump construction
Inventor: FEDORIV M L
IPC: E02D31/02
Filed: 2000-11-30
Granted: 2002-07-10
Abstract: FIELD: methods of operations in hydraulic engineering and methods of construction of dumps for wastes of oil and gas production in well cluster drilling and well operation. SUBSTANCE: method includes marking of boundaries and configuration of land allocations, pouring off or washing up ground, hydraulic proofness of process area, external embankment of process area peripheries, location of production and consumption wastes on territory of area between external and internal embankments which are made round positions of abandoned wells. EFFECT: efficient use of land resources, reduced harmful effect on environment. 1 dwg
Patent RU-2186545-C1 (RU)
Title: Method for surgical treatment of cirrhosis and intrahepatic portal hypertension
Inventor: GUZHINA A O
IPC: A61B18/20
Filed: 2001-05-14
Granted: 2002-08-10
Abstract: FIELD: medicine, surgery. SUBSTANCE: a source of high-intensive laser radiation is in succession introduced into hepatic tissue in sites situated at 1.5-2.0 cm space at the depth of, at least, 1.0 cm. Damaging impact is conducted with radiation of neodymium or diode lasers at the power of at least 1.0 W. The time of damaging impact foe every site corresponds to at least 1.0 sec. EFFECT: higher efficiency of therapy.
Patent RU-2190121-C1 (RU)
Title: Internal combustion engine heater
Inventor: MAL TSEV PAVEL VASIL EVICH
IPC: F02N19/10
Filed: 2001-05-29
Granted: 2002-09-27
Abstract: FIELD: mechanical engineering; internal combustion engines. SUBSTANCE: invention is designed for use in cooling system of internal combustion engine where accumulation, storage and delivery of heat to engine at starting is provided by heat accumulator. Hydraulic distributor is placed in internal combustion engine cooling duct containing heat accumulator with additional circulation drive and drive control unit in parallel to heat accumulator and additional drive. Hydraulic distributor is made in form of two non-return valves with springs installed opposite to each other. One valve is connected to engine outlet, and the other, to heat accumulator outlet. Rigidity of spring of second valve exceeds that of first valve by value equivalent to valves pressure differential to provide possibility of operation. EFFECT: simplified design at preservation of high reliability, improved manufacturability and reduced cost of manufacture. 2 cl, 1 dwg
Patent RU-2198141-C1 (RU)
Inventor: KARMAZINOV F V
IPC: C02F11/00
Filed: 2001-06-29
Granted: 2003-02-10
Abstract: FIELD: ecological protection of nature from waste water sludges, particularly, sanitary engineering; applicable in utilization of sludges of municipal and production sewage waters. SUBSTANCE: system includes the following units: (a) dewatering unit; (b) drying and combustion unit; (c) unit for removing of ash from exhaust gases; (d) flue gases cleaning unit. System is additionally provided with water-to-water heat exchanger with branch pipes of heated water inlet and outlet installed on circulating alkali circuit. Service water pipeline is connected to heated water inlet branch pipe and heated water outlet branch pipe is connected to flocculant mixer. System is also equipped with automatic process control system, unit 1 of preparation for sludge dewatering installed ahead of unit (a) and including primary settling tanks with at least one pumping station of sediment with drive, suction and pressure pipelines, compactors of excess activated sludge with tank and pumping station of compacted sludge with drive, suction and pressure pipelines, sludge tank. Dewatering process lines are additionally provided with sludge temperature gage. Pressure pipelines of sediment pumping station and pressure pipelines of compacted sludge pumping station are connected with sludge tank. Drives of pumping stations of sediment, compacted excess sludge, sludge metering pumps and flocculants are made in the form of frequency-regulated electric drive by frequency converter-asynchronous motor system including asynchronous electric motors and static frequency converters which together with concentration transducer, temperature gage, sludge flowmeter, temperature pickup of effluent gases and temperature pickup of fluidization are connected with automatic process control system. EFFECT: higher efficiency of use. 3 cl, 1 dwg
Patent RU-2192042-C1 (RU)
Inventor: EFITOV G L
IPC: G06Q10/06
Filed: 2001-10-02
Granted: 2002-10-27
Abstract: FIELD: quality control systems. SUBSTANCE: method involves creating three databases like specification documents database, actual quality database of technological flowcharts in all plants, marketable product certificates database on a chemical technology enterprise. Database interconnection and mentioned database maintenance is organized. In creating the specification documents database State standards, enterprise standards, technical specifications on marketable products quality and quality level of all technological flowcharts on the enterprise are used. When creating the actual quality database of technological flowcharts in all plants, results of daily technological flowchart analysis according to analytical control schedule concerning the technological plants and actual values of the received quality factors of each technological flowchart at particular time moment on particular plant are entered into the actual technological flowchart quality database describing all plants. When creating marketable product certificates database results of marketable products quality analyses are used in keeping in view its production in all production reservoirs. The data describing certification values of quality factors both relative to the technological flowcharts and marketable products are taken from the specification documents database dealing with organizational interrelation of all databases. Then the actual values of the factors are averaged on calendar time intervals to be reflected in reports to follow analytical control schedule maintenance and marketable product quality specification requirement compliance. EFFECT: enhanced effectiveness of on-line quality control.
Patent RU-2192848-C1 (RU)
Inventor: KRIVOSHEEV S A
IPC: A61K9/20
Filed: 2001-10-30
Granted: 2002-11-20
Abstract: FIELD: medicine, particularly, pharmaceutical preparations used as antiemetic agents, blockers of dopamine receptors. SUBSTANCE: antiemetic remedy contains, as an active component, domperidone, and as auxiliary components: starch, milk sugar, microcrystalline cellulose, aerosil, polyvinylpyrrolidone, stearic acid or its salts, and modified starch or crosscarmelose at definite ratio of components. Used as modified starch is sodium carboxymethylstarch, and quantity of modified starch and/or crosscarmelose must be 1-20% from untreated starch. EFFECT: guaranteed decomposition and quick release of medicinal agent. 6 cl, 1 ex
Patent RU-2211627-C1 (RU)
Inventor: JUSHINA E A
IPC: C12P1/02
Filed: 2002-04-17
Granted: 2003-09-10
Abstract: FIELD: food industry. SUBSTANCE: invention relates to food-concentrate technology, in particular to drink concentrate production. Method is distinguished by that, prior to be peeled, bananas are treated with preparation obtained from biomass of micromycete Pythium ultimum according to given technology and aged for 2 to 5 h. Pulp is then disintegrated to give juice, peel is hydrolyzed, and separated hydrolyzate is blended with juice. EFFECT: eliminated opalescence of base and increased productivity. 2 ex
Patent RU-2205507-C1 (RU)
Title: Noise suppressing device
Inventor: CHUGAEVA V I
IPC: H04B1/10
Filed: 2002-04-19
Granted: 2003-05-27
Abstract: FIELD: radio engineering. SUBSTANCE: device designed for suppressing broadband phase-keyed noise is provided with newly introduced two multipliers, adjustable rejection filter, phase demodulator, switch, commutator, and threshold comparison unit which makes it possible to eliminates influence of such factors as multiplicity of channel beams and variations in phase-keyed noise carrier frequency. EFFECT: enhanced degree of noise suppression. 1 cl, 4 dwg
Patent RU-2219313-C1 (RU)
Title: Gear to smooth out and compact ground
Inventor: BYCHKOV A I
IPC: E02D17/20
Filed: 2002-06-17
Granted: 2003-12-20
Abstract: FIELD: construction industry. SUBSTANCE: invention refers to equipment intended for earth-moving operations, for leveling and compaction of earth structures. Gear to smooth out and compact ground includes prime mover, working tool hinged to prime mover. Working tool comes in the form of blade that can be set in position " on the edge " to smooth ground and has relief base to form recesses over compacted surface of ground. EFFECT: increased operational reliability of gear. 2 dwg
Patent RU-2213615-C1 (RU)
Inventor: MOKRINSKIJ V V
IPC: B01J23/02
Filed: 2002-06-27
Granted: 2003-10-10
Abstract: FIELD: oxidation catalysts and inorganic compounds technology. SUBSTANCE: catalyst contains manganese-containing active component, alkali metal oxide or oxide mixture, and alumina, said active component being, more specifically, mixed amorphous oxide phase with non-stoichiometric composition: MnBi y O y (0,05≤x≤2,24;2,08≤y≤5,36) or mixture of amorphous phase MnBi x O y  and crystalline manganese- containing phase. Nitrous oxide is prepared in presence of indicated catalyst via oxidation of ammonia with oxygen or oxygen-containing gas at 250-450 C. Product is intended to be used in semiconductor engineering, perfumery, medicine, and food industry. EFFECT: enhanced activity and selectivity of catalyst at lower active component content. 6 cl, 1 tbl, 9 ex
Patent RU-2218965-C1 (RU)
Title: Seat for attraction
Inventor: GNEZDILOV V A
IPC: A63G9/00
Filed: 2002-07-15
Granted: 2003-12-20
Abstract: FIELD: entertainment industry. SUBSTANCE: seat for attraction has outer panel provided with protrusion, and base provided with protrusion positioned inside cavity of outer panel. Seat of such construction may be used in various attractions, such as swing, switchback, free falling tower etc. EFFECT: simplified construction and increased safety of attraction. 4 cl, 1 dwg
Patent RU-2222716-C1 (RU)
Title: Method of operation of well jet plant at hydrodynamic bottom hole zone treatment
Inventor: KHOMINETS ZINOVIJ DMITRIEVICH
IPC: F04F5/02
Filed: 2002-12-16
Granted: 2004-01-27
Abstract: FIELD: oil producing industry. SUBSTANCE: invention relates to pumping facilities designed for production of oil. According to proposed method, packer and jet pump with channels for admission of working agent and for pumped out formation fluid mounted on tubing string are lowered into well. Jet pump and packer are installed over top of productive stratum and packer releasing is carried out. Working agent is periodically delivered into jet pump nozzle. Delivery of working agent is provided at the following mode: first working agent is sharply delivered into nozzle of jet pump at preset pressure of pumping unit, differential pressure of productive stratum is built in 5-10 sec and said differential pressure is maintained from 2 to 20 min by constantly delivering working agent into jet pump nozzle at preset pressure of pumping unit, then repressing is built abruptly in 2-5 sec in form of water hammer by action of working agent from tubing string onto productive stratum owing to sharply changing over its delivery from tubing string through channel delivering pumped out formation fluid under-packer space. Water hammer is directed towards productive stratum leading to rear-off of particles in porous channels of productive stratum and forming micracks in bottom hole zone at working agent pressure on productive stratum exceeding formation pressure. Then entire working agent is sharply delivered into jet pump nozzle, and bottom hole zone treatment cycle by action of differential pressure and repressing is repeated. Number of "differential pressure - repressing" cycles is determined by degree of restoration of permeability of bottom hole zone revealed by checking production rates of well before and in process of cyclic action onto bottom hole zone. If output of well determined in two last checks has not increased, work is stopped. As a result, reliability and capacity are increased owing to restoration of permeability of bottom hole zone. EFFECT: increased yield of production and intake capacity of injection wells. 4 cl, 1 dwg
Patent RU-2237254-C1 (RU)
Inventor: ALJUNOV A N
IPC: G01R31/62
Filed: 2003-01-08
Granted: 2004-09-27
Abstract: FIELD: electric engineering. 
     SUBSTANCE: method involves measuring values and phase angles of voltages and currents in all transformer windings in two operation modes, recording measured currents and voltage drop values, selecting the first harmonic component of the recorded currents and voltages in windings, determining symmetric components of received currents and voltages. Short-circuit resistance Z k  and loss P k , idle running current I 0  and loss P 0 , active and inductive resistances of each winding are determined. Transformation coefficient K is calculated. Resistance of zero sequence is determined from asymmetric operation mode parameters. The values of Z k , Z 0 , P k , I 0  and P 0 , exceeding some reference values, technical condition and working capacity of transformer is diagnosed. 
     EFFECT: wide range of functional applications; low cost; high reliability. 
     4 cl, 3 dwg
Patent RU-2235449-C1 (RU)
Inventor: DZHAVADOV R D
IPC: A01B13/02
Filed: 2003-03-24
Granted: 2004-09-10
Abstract: FIELD: agricultural engineering, in particular, equipment used for cultivation of potato tubers planted on ridges. 
     SUBSTANCE: general-purpose tool has tine with A-hoe and adjustment mechanism. Detachable two-tier small-sized moldboards are fixed above A-hoe. Ridge-former includes two symmetrically arranged sides 4 made in the form of rectangular triangles with hypotenuses directed downward and connected by loops. Ridge-former is positioned above and between moldboards. Sides are equipped with cutting knives and rippers. Leveler-moisture retainer is made in the form of toothed comb mounted on sides. Side adjustment mechanism is made in the form of screws. 
     EFFECT: increased efficiency in forming of full-value ridge during hilling of potato plant, said ridge having desired parameters and characteristics satisfying agrotechnical requirements. 
     8 dwg
Patent RU-2240028-C1 (RU)
Inventor: OSTROVSKIJ A I
IPC: A61B1/233
Filed: 2003-04-16
Granted: 2004-11-20
Abstract: FIELD: medicine; medical engineering. 
     SUBSTANCE: device has structure with no permanent fastening. It is designed as flat rubber cuff having membranes of various thickness and polymer tube mounted therein. The tube is connected to manometer, two-threshold relay pressure gage and electronic stopwatch. Method involves introducing flat rubber cuff into common nasal entrance turned with thinner membrane towards inferior nasal concha and with thicker one towards nasal partition, rapidly pumping and compressing the inferior nasal concha until the first automatic response of the two-threshold relay pressure gage and stopwatch response to high pressure switching off compressor occur. The second response time is recorded on falling down and stabilizing pressure event when reducing inferior nasal concha volume. Tissue density is calculated from known formula. 
     EFFECT: low device mass; available portable version; high accuracy and low invasiveness degree. 
     2 cl, 3 dwg
Patent RU-2234569-C1 (RU)
Title: Fish-pass
Inventor: CHISTJAKOV A A
IPC: E02B8/08
Filed: 2003-04-25
Granted: 2004-08-20
Abstract: FIELD: hydraulic building, particularly fish-passes for passing fish through support structures to spawning and growth zones. 
     SUBSTANCE: fish-pass includes fish passageway connecting upper and lower pools of hydrosystem, flow energy absorber arranged inside fish passageway and made as flexible endless strips located along longitudinal axis of fish passageway. Endless strips are supported by tension guide pulleys and may be moved by driving means so that channel is formed between strips. Fish-pass also has roughened members and guiding walls located parallel to along longitudinal axis of fish passageway. Guide pulleys are disposed in depressions formed in side walls of fish passageway and are buried inside said depressions. Roughened members are fixedly connected to outer surfaces of flexible endless strips. Feed pulleys of flexible endless strips are connected to driving means. 
     EFFECT: creation of favorable hydraulic conditions for passing fish through fish passageway with minimum energy. 
     33 cl, 39 dwg
Patent RU-2227817-C1 (RU)
Inventor: KANAREV F M
IPC: C25B9/17
Filed: 2003-06-16
Granted: 2004-04-27
Abstract: Электролитическая ячейка содержит конический корпус, изготовленный из токопроводящего материала и выполняющий роль катода, дополнительные конические электроды, коническую крышку из токопроводящего материала, выполняющую роль анода. Цилиндрические основания корпуса, дополнительных электродов и крышки имеют кольцевые выемки для размещения диэлектрического кольца. Корпус, дополнительные электроды и крышка соединяются болтами, вставленными в отверстия цилиндрических оснований корпуса, дополнительных электродов и крышки. Изоляция между анодом, дополнительными электродами и катодом обеспечивается диэлектрическими кольцами, диэлектрическими шайбами и диэлектрическими втулками. Раствор подается в межэлектродное пространство через канал из емкости. Газы выходят через патрубок. Технический эффект - создание условий для поляризации ионов раствора и молекул воды в двух плоскостях: горизонтальной и вертикальной, в результате чего на аноде появляется положительный, а на катоде - отрицательный потенциалы еще до включения ячейки в электрическую сеть и процесс выделения газов продолжается и после отключения ячейки от сети. За счет этого затраты энергии на процесс разложения воды на водород и кислород значительно уменьшаются. 1 ил., 1 табл.
Patent RU-2239254-C1 (RU)
Inventor: IVLJUSHKIN A N
IPC: H01J17/49
Filed: 2003-10-13
Granted: 2004-10-27
Abstract: Изобретение относится к электронной технике и может быть использовано при создании индикаторных устройств на газоразрядных индикаторных панелях (ГИП). Сущность: ГИП содержит две диэлектрические пластины, ячейки индикации, образованные в перекрестьях проволочных анодов и катодов, выполненных из усеченной по длине проволоки. Аноды и катоды расположены на диэлектрических пластинах в слое легкоплавкого стекла, при этом поверхности легкоплавкого стекла лежат в одной плоскости с рабочей поверхностью электродов, образованной в результате усечения проволоки. Технический результат: повышение надежности работы за счет повышения точности фиксирования проволочных электродов на подложке и исключения взаимного влияния между соседними проволочными электродами. 1 ил.