baber/WOPTO huggingface dataset:
Patent WO-2018187521-A3 (WO)
Title: Methods of detecting cell-free dna in biological samples
Inventor: DE VLAMINCK IWIJN
IPC: C12Q1/70
Filed: 2018-04-05
Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.
Patent WO-2019018234-A3 (WO)
Title: Proppants and process for making the same
Inventor: SHI JINGYU
IPC: C09K8/80
Filed: 2018-07-13
Abstract: A plurality of proppant particles that includes ultra fine and fine fractured proppants particles with certain physical and chemical characteristics is disclosed. The fractured proppant particles of this invention can be tailored to provide fracture slurries that have the characteristics needed to address the technical issues that arise during the fracturing and extraction phases of an oil well's life span.
Patent WO-2021207213-A3 (WO)
Title: Methods to prevent sars-cov-2 infection and treat covid-19
Inventor: OSTROV DAVID A
IPC: C07K14/165
Filed: 2021-04-06
Abstract: Methods of preventing or treating infection by a SARS-CoV-related betacoronavirus are described. The methods include administering to a patient at risk of being infected by a SARS-CoV-related betacoronavirus or suffering from SARS-CoV-related betacoronavirus-related illness a small molecule drug and/or an antibody that binds to the ACE2-SARS interaction domain of either ACE2 or SARS-CoV-2 spike protein. Also described are vaccines comprising S-protein polypeptides corresponding to the ACE-2 interaction domain.
Patent WO-2021231305-A3 (WO)
Title: Viral delivery vehicle selection
Inventor: JENSEN MARTIN BORCH
IPC: C12N15/86
Filed: 2021-05-10
Abstract: Provided herein are libraries of delivery vehicles and methods of uses thereof. The delivery vehicles provided include distinct variants of a virus and nucleic acid sequences encoding a distinct virus-identifying barcode region specific for each virus variants, and a nucleic acid sequence encoding at least one reporter. The methods provided herein include methods of identifying a vehicle effective in targeting a particular cell type.
Patent WO-2023097061-A3 (WO)
Title: Markers and cellular antecedents of rheumatoid arthritis flares
Inventor: DARNELL ROBERT
IPC: G01N33/564
Filed: 2022-11-25
Abstract: The present disclosure provides biological markers which are molecular and cellular antecedents of rheumatoid arthritis (RA) flares. The present disclosure provides RNA and protein markers that can predict an RA flare one or two weeks prior to the flare. The present disclosure further provides blood circulating cells, particularly pre-inflammatory mesenchymal cells, which are cellular precursors and indicators of an impending RA flare. The present disclosure further provides methods, kits and markers for identification and monitoring of flares in RA patients and their application as markers and targets in and for treatment of rheumatoid arthritis and conditions induced or related to rheumatoid arthritis.
Patent WO-2023158712-A3 (WO)
Title: System and method for making thick-multilayer dielectric films
Inventor: BLUCK TERRY
IPC: C23C14/56
Filed: 2023-02-15
Abstract: A linear processing system having an entry loadlock, a first multi-pass processing chamber coupled to the entry loadlock, the first multi-pass processing chamber having a sputtering magnetron arrangement and configured to house a single substrate carrier for performing a multi-pass processing; a single-pass chamber coupled to the first multi-pass processing chamber and having a plurality of magnetron arrangements arranged along a carrier travel direction, the single-pass chamber configured to house multiple carriers arranged serially in a row and configured for a single-pass processing; a second multi-pass processing chamber coupled to the single-pass processing chamber, the second multi-pass processing chamber having a sputtering magnetron arrangement and configured to house a single substrate carrier for performing a multi-pass processing; and an exit loadlock chamber coupled to the second multi-pass processing chamber
Patent WO-2023164613-A3 (WO)
Inventor: FROST HOLLY M
IPC: C12Q1/04
Filed: 2023-02-24
Abstract: A method for identifying the etiology of acute otitis media in a clinically diagnosed subject is provided. Also provided is a method to determine a treatment protocol in a subject clinically diagnosed with otitis media. Analyzing a test result indicating presence or absence of negative beta-lactamase H. injluenzae, positive beta-lactamase H. influenzae, M. catarrhalis, and S. pneumoniae from a biological sample from the subject to determine if S. pneumonia is present or absent.
Patent WO-2023196984-A3 (WO)
Title: Multifunctional nanoparticles and uses in managing cancer and cardiovascular diseases
Inventor: YANG LILY
IPC: A61K9/51
Filed: 2023-04-07
Abstract: This disclosure relates to nanoparticles comprising a cardiovascular agent, a PD-L1 binding agent on the surface, and optionally an anticancer agent. In certain embodiments, the cardiovascular agent is an inhibitor of cholesterol acyltransferase such as avasimibe. In certain embodiments, the nanoparticles comprise a hyaluronic acid core. In certain embodiments, this disclosure relates to methods of treating or preventing cancer and/or atherosclerosis, or other cardiovascular disease by administering an effective amount of nanoparticles disclosed herein to a subject in need thereof.
Patent BE-1009644-A4 (BE)
Title: Roterende oven.
Inventor: TAQUET HENRI JEAN-PIERRE JOSEP
IPC: F27B7/20
Filed: 1995-10-06
Granted: 1997-06-03
Abstract: De uitvinding heeft betrekking op een roterende oven met een horizontale of hellende trommel waarvan ten minste de binnenzijde uit een vuurvast materiaal vervaardigd is en die verdraaibaar om haar longitudinale as gemonteerd is. De trommel bevat een buisvormig element (1) uit een vuurvast materiaal dat samengesteld is uit een opeenvolging van tegen elkaar steunende coaxiale ringen (2), welk element (1) vanaf zijn beide uiteinden (6) onder een axiale spanning gebracht wordt ten einde een zelfdragend voorgespannen geheel te verkrijgen.
Patent EP-1153928-A4 (EP)
Title: 2-methyl-3-butenyl-1-pyrophosphoric acid salts and agents for treating lymphocytes
Inventor: TANAKA YOSHIMASA
IPC: A61K35/17
Filed: 2000-01-21
Abstract: A pharmaceutically acceptable salt of 2-methyl-3-butenyl-1-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-1-pyrophosphoric acid, a pharmaceutically acceptable salt thereof, and a hydrate thereof; V gamma 2V delta 2 type T cells treated by the same; and a medicine containing the same specifically stimulate and proliferate the human V gamma 2V delta 2 type T cells, and also induce and enhance an antitumor activity thereof.
Patent EP-1224497-A4 (EP)
Inventor: MEDA GAUTAM
IPC: G02B1/02
Filed: 2000-06-22
Abstract: La présente invention concerne une lentille (50) optique pour lithographie VUV à cristaux de fluorure qui minimise l'effet biréfringent, convenant pour des longueurs d'ondes inférieures à 230 nm. Cette lentille pour lithographie VUV possède un axe optique entouré par un périmètre de lentille, et la lentille à cristaux de fluorure présente une variation (58) d'orientation cristallographique, celle-ci étant inclinée par rapport à l'axe optique central (54), en direction du périmètre de la lentille de façon à minimiser l'effet biréfringent.
Patent EP-1232675-A4 (EP)
Title: Mounting arrangement for auxiliary burner or lance
Inventor: SHVER VALERY G
IPC: F27D27/00
Filed: 2001-02-06
Abstract: A mounting block and an improved mounting arrangement for apparatus used in metal melting, refining and processing, particularly those apparatus adapted to steel making in an electric arc furnace, such as burners, lances and the like with supersonic oxygen lancing capability. The mounting block is fluid cooled to survive the hostile environment of the electric arc furnace and is designed to rest on the step between the side wall and hearth of the furnace without any substantial change to the structure of the furnace. The mounting block comprises a plurality of fluid cooling conduits surrounding an aperture which is formed through the block and adapted to mount the apparatus. The mounting arrangement includes utilizing the mounting block to mount an apparatus with supersonic oxidizing gas or lancing capability in an electric arc furnace. The apparatus is mounted by passing it through an aperture in a water cooled side panel aligned with the mounting aperture in the mounting block. Because the mounting block is approximately the width of the step, the discharge opening of the apparatus is moved closer to the surface of the melt and toward the center of the furnace thereby providing increased efficiency. The discharge opening will now also extend past the inner edge of the step so that the oxidizing gas flow pattern does not degrade the hearth material and other furnace equipment mounted nearby.
Patent EP-1206170-A4 (EP)
Inventor: SUETSUGU KENICHIRO
IPC: H05K3/40
Filed: 2001-03-14
Abstract: L'invention concerne une structure liée comprenant une carte pourvue d'un trou traversant, une pastille disposée à la périphérie de ce trou traversant, ainsi qu'une broche de raccordement issue d'une partie électronique et logée dans le trou traversant. Cette pastille comporte une partie de pastille de côté de paroi sur le côté de paroi du trou traversant, et des parties de pastille de surfaces avant et arrière sur les surfaces avant et arrière de la carte. Une zone de connexion destinée à connecter la pastille à la broche de raccordement comprend des parties de zone de connexion supérieure et inférieure touchant respectivement les parties de pastille de surface avant et arrière. Le contour de la zone de connexion supérieure est plus petit que celui de la zone de connexion inférieure, mais plus important que le périmètre du trou traversant. Lorsqu'une matière de soudure sans plomb est utilisée, le risque d'arrachement peut être réduit efficacement par rapport à une carte à circuit imprimé classique.
Patent EP-1275758-A4 (EP)
Title: Monofilament yarn and process for producing the same
Inventor: YUUKI YASUNORI
IPC: D01F6/62
Filed: 2001-03-28
Abstract: The present invention provides a polytrimethylene terephthalate monofilament yarn excellent in softness, bending recovery or durability against a long term use. The inventive polytrimethylene terephthalate monofilament yarn is constituted by trimethylene terephthalate composed of 90 mol% or more of trymethylene terephthalate repeating units and 10 mol% or less of other ester repeating units, wherein the yarn has a single-fiber size of 50 dtex or more, an intrinsic viscosity in a range from 0.8 to 1.3 dl/g, and a boiling water shrinkage of 2% or less.
Patent EP-1307736-A4 (EP)
Title: A quantitative, high-throughput screening method for protein stability
Inventor: OAS TERRANCE G
IPC: G01N33/68
Filed: 2001-04-30
Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described, herein, are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed. The method includes the steps of (a) providing a test protein; (b) contacting the protein with an exchange buffer comprising a denaturant and deuterium, the exchange buffer having a denaturant concentration; (c) contacting the protein with a mass spectrometry matrix medium; (d) determining a change in mass of the test protein by mass spectrometry; (e) varying the denaturant concentration of the exchange buffer; (f) repeating steps (a)-(e) a desired number of times; and (g) quantitatively determining protein stability based on the change in mass of the test protein as a function of denaturant concentration, whereby the stability of a test protein under the native conditions is quantitatively determined.
Patent EP-1299336-A4 (EP)
Title: Rho-isoalpha acid hop products and methods
Inventor: WILSON RICHARD J H
IPC: C12C3/08
Filed: 2001-06-29
Abstract: Aqueous concentrated compositions of an alkali metal salt of rho-iso-±-acids for use as brewing additive are prepared by mixing alkali
Patent EP-1268258-A4 (EP)
Inventor: WILLIAMS DANIEL E
IPC: B62D5/09
Filed: 2001-03-30
Abstract: L'invention concerne un dispositif de direction (10) destiné à un véhicule pourvu de roues directionnelles en contact avec la route. Ledit dispositif comporte un volant rotatif (11) et un capteur (12) détectant la position de rotation du volant et produisant un premier signal correspondant à la position de rotation détectée du volant (11). Un premier moteur électrique (14) s'oppose à la rotation du volant (11) lorsqu'il est alimenté. Un deuxième moteur électrique (20) est commandé par le signal produit par le capteur destiné à détecter la position de rotation du volant (11). Un mécanisme de direction (130) est actionné par le deuxième moteur électrique (20) de manière à tourner les roues directionnelles du véhicule. Un circuit électrique (19) contient les premier et deuxième moteurs (14, 20) en série.
Patent EP-1340690-A4 (EP)
Title: Packaging material and information recording media packaged by packaging material
Inventor: KAKU TOSHIYUKI
IPC: B32B7/12
Filed: 2001-09-21
Abstract: The present invention relates to a packing material used for wrapping an article to be packed and sealing and packing the article to be packed by heat-sealing mutually superposed end parts. The packing material is composed of a biodegradable film. Heat sealing agent layers are selectively provided in the heat sealing positions or the heat-sealed parts of the biodegradable film. The heat sealing agent layers are provided on the front surface and the back surface, the front surface and the front surface, or the back surface and the back surface of the mutually superposed biodegradable film when the article to be packed is packed. On the biodegradable film, picture pattern layers as well as the heat sealing agent layers are formed within a range 70 % or less as large as the entire area including the front surface and the back surface of the biodegradable film. <IMAGE>
Patent EP-1332546-A4 (EP)
Inventor: PROVANZANA JOHN M
IPC: H02J3/28
Filed: 2001-10-10
Abstract: La présente invention concerne un système de distribution et de stockage d'énergie électrique basé sur des condensateurs qui peut effectuer le nivellement de la charge pendant les périodes de pointe d'un service (voir figure 8). Un condensateur (400) peut être chargé avec l'énergie électrique produite par le service (510) pendant les périodes de faible demande. A l'inverse, l'énergie électrique stockée dans les condensateurs (400) peut être injectée dans le réseau de distribution (510) pour augmenter la quantité d'énergie électrique disponible pour la consommation.
Patent EP-1283662-A4 (EP)
Title: It laminating double-side circuit board and production method therefor and multi-layer printed circuit board using
Inventor: TAKASE YOSHIHISA
IPC: H05K3/40
Filed: 2002-01-29
Abstract: A multi-layer printed circuit board comprising, placed one upon another, a plurality of laminating double-side circuit board and a plurality of interlayer connecting prepregs, wherein a via hole extending from a conductor circuit side on one surface of the laminating double-side circuit board up to the conductor circuit on the other surface is provided and is filled with a conductive substance to mutually connect conductor circuits on the opposite surfaces of the laminating double-side circuit board, a pad portion of a laminating double-side circuit board and a pad portion of another laminating double-side circuit board are stacked via an interlayer connecting prepreg so as to allow a conductive substance-filled through hole in the interlayer connecting prepreg to face the pad portions, thereby electrically connecting the pad portions on the surfaces of the laminating double-side circuit boards. Accordingly, multi-layer printed circuit board excellent in connecproduction time.
Patent EP-1298578-A4 (EP)
Inventor: ARISAWA SHIGERU
IPC: B42D15/10
Filed: 2002-01-24
Abstract: La présente invention concerne un dispositif électronique visant à supprimer la perte de sensibilité de réception et la distorsion du signal dans les cas d'utilisation des cartes circuits imprimés dans un empilement. La carte circuit intégré est équipée d'une antenne en boucle (1) faite de quatre tours d'enroulement, chaque tour réunissant notamment un segment linéaire (L2), un segment courbe (L3), un segment linéaire (L4) et un segment courbe (L5). La superposition inverse de deux antennes boucles (1) de cette forme évite la superposition des coins. Par exemple, un coin comprenant le segment courbe (L3) et le segment linéaire (L4) de l'antenne boucle (1) vient en superposition du segment courbe (L3) de l'antenne boucle (1) en superposition inverse, ce qui fait que, dans l'ensemble, le coin n'est pas en superposition avec un petit nombre de segments superposés. Cette invention convient particulièrement à une carte circuit imprimée destinée au transfert de données sans contact.
Patent EP-1463459-A4 (EP)
Inventor: PINCHASIK GREGORY
IPC: A61F2/06
Filed: 2002-05-21
Abstract: L'invention concerne un stent intravasculaire convenant spécialement à une implantation dans des parties artérielles courbées. Le stent conserve une flexibilité longitudinale après expansion. Le stent est formé de méandres entremêlés, qui forment des cellules triangulaires, cellules adaptées pour fournir un support radial, ainsi qu'une flexibilité longitudinale après expansion. Les cellules triangulaires permettent une couverture accrue de la paroi vasculaire. Le stent peut avoir différentes parties adaptées, pour optimiser le support radial ou la flexibilité longitudinale. Des boucles du stent sont disposées et adaptées de façon à coopérer, de sorte qu'après son expansion, à l'intérieur d'une lumière incurvée, ledit stent est courbe, et les cellules à l'extérieur de la courbe s'allongent, mais se réduisent en largeur, alors que les cellules à l'intérieur de la courbe se réduisent en longueur mais s'agrandissent en largeur, afin de maintenir une densité de la superficie des éléments du stent, beaucoup plus constante que normalement, entre l'intérieur et l'extérieur de la courbe. Ainsi, lorsque le stent est enduit d'un médicament, la densité plus constante des éléments du stent fait qu'une dose régulière est appliquée sur la paroi interne de la lumière, ce qui empêche qu'une dose toxique soit appliquée en ce point, et qu'une dose moins efficace soit appliquée en un autre point.
Patent EP-1383652-A4 (EP)
Title: Ionomer laminates and articles formed from ionomer laminates
Inventor: DOMINE JOSEPH D
IPC: B29C45/14
Filed: 2002-03-21
Abstract: A laminate structure having at least one layer of an ionomer resin (a) and at least one layer of an acid polymer or a blend of an acid polymer and a thermoplastic polyolefin (b) that can be thermoformed to form a shaped article and additional polyolefin substrate can be provided. The laminate can be pigmented to eliminate the need to paint the surface of the plastic substrate. The laminate is useful in the production of automotive parts and sports equipment.
Patent EP-1424169-A4 (EP)
Title: Cartridge
Inventor: HARAMIISHI KIICHI
IPC: B27F7/38
Filed: 2002-08-09
Abstract: A cartridge comprises a sheet staple detecting mechanism (60) for detecting presence and absence of sheet staples (ST) stacked on a bottom having an opening (23A), The sheet staple detecting mechanism (60) includes a detected member (30) having leg parts (32, 32, 33 and 33), which are disposed on the uppermost surface of the stacked sheet staples (ST) and configured to be inserted in the opening (23A) when the sheet staples (ST) are not disposed on the bottom (23), an actuator (40) rotated at the time the leg parts (32, 32, 33 and 33) are inserted in the opening (23 A), and a micro-switch (50) for detecting the rotation of the actuator (40). <IMAGE>
Patent EP-1444528-A4 (EP)
Title: Electrical test probes and methods of making the same
Inventor: SOUZA THERESA R
IPC: G01R1/067
Filed: 2002-09-24
Abstract: A probe plunger and method of making are provided. The probe plunger includes an outer layer of a relatively hard, relatively low contact resistance such as a palladium-cobalt alloy. In some embodiments, a portion of the exterior surface includes at least one region of a self-limiting oxide.
Patent EP-1450632-A4 (EP)
Inventor: HAMPL VLADIMIR JR
IPC: D21H27/00
Filed: 2002-10-18
Abstract: La présente invention concerne d'une manière générale des articles de fumeur présentant une émission réduire de monoxyde de carbone. Pour réduire l'émission de monoxyde de carbone, les papiers à cigarettes utilisés pour fabriquer l'article de fumeur présentent un grammage de fibre inférieur à environ 18 g/m2. Les articles de fumeur fabriqués selon la présente invention peuvent ainsi présenter une émission de monoxyde de carbone inférieure à 18 mg par article de fumeur.
Patent EP-1471056-A4 (EP)
Inventor: KAWAKAMI JUN-ICHI
IPC: C07D233/54
Filed: 2003-01-09
Abstract: L'invention concerne un procédé industriel avantageux pour l'élaboration d'inhibiteur de C17, 20 - lyase stéroïde représenté par la formule générale (I); et un réactif de Reformatsky sous forme stable, approprié à l'utilisation dans le processus de production correspondant. L'opération consiste à réduire un dérivé de composé de β-hydroxy ester spécifique issu d'un composé carbonyle spécifique, par la réaction de Reformatsky, ou un sel correspondant du composé, en présence de composé de complexe métal/hydrogène et d'un halogénure de métal, que l'on soumet ensuite à une cyclisation, donnant un composé représenté par la formule générale (I). Pour les besoins de ladite formule, les symboles sont tels que définis dans la description. S'agissant de la réaction de Reformatsky, une solution stable du composé représenté par BrZnCH2COOC2H5, ou des cristaux du composé représenté par (BrZnCH2COOC2H5.THF)2, sont utiles.
Patent EP-1476951-A4 (EP)
Title: Crosstalk mitigation in a modem pool environment
Inventor: ZAMIR RAM
IPC: H04B3/32
Filed: 2003-01-20
Abstract: In a modem pool system capable of mitigating alien crosstalk, a system including a first modem pool including at least two modems, at least one protected line connected to one of the modems, at least one sensor line connected to another of the modems, at least one alien crosstalk predictor operative to sample an alien signal on the at least one sensor line and provide an alien crosstalk prediction signal, and at least one alien crosstalk prediction summation element operative to receive the alien crosstalk prediction signal from the alien crosstalk predictor and subtract the alien crosstalk prediction signal from a data transmission signal on the protected line.