baber/WOPTO huggingface dataset:
Patent DE-69026380-D1 (DE)
Inventor: LOUGHREY HELEN
IPC: A61K47/48
Filed: 1990-06-22
Granted: 1996-05-09
Abstract: This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subseuquently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates. The present invention also relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm. The liposomes of the invention may have a trans-membrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineoplastic agents, and may be used in diagnostic assays.
Patent DE-69029270-D1 (DE)
Inventor: BROWN JOSEPH
IPC: C07K16/00
Filed: 1990-09-10
Granted: 1997-01-09
Abstract: The present invention relates to a novel monoclonal antibody reactive with human colorectal mucin antigen. More particularly, the antibody of the invention is a murine monoclonal antibody, CT43, reactive with a novel antigenic determinant on much antigen highly correlated with human colorectal cancer. The antigenic determinant found by the CT43 has been characterized as neuraminidase and proteinase K resistant, periodate sensitive and unreactive with the glycoconjugates of Table 2. Methods are provided for the detection and quantitation of the CT43 antigenic determinant and its correlation with colorectal cancer. CT43, and CT66 specific for the sialylated Lewis a and Lewis a antigen have been deposited with the American Type Culture Collection, as accession numbers ATCC HB 10217 and ATCC HB 10218, deposited Sep. 6, 1989.
Patent DE-69033090-D1 (DE)
Inventor: SHKONDIN VASILIJ VASILIEVICH
IPC: H02K25/00
Filed: 1990-08-24
Granted: 1999-06-10
Abstract: A motor-wheel for electromobiles, bicycles, invalid wheel-chairs, in which the electromagnets (14, 15) of the rotor (12) of a commutator electric motor are arranged along a circumference in a pair of groups offset in relation to each other, whereas the commutating collector (6) of the stator (9), electrically connected to an electric energy accumulator (32), is so designed that when the magnetic axes (17, 18) of the electromagnets (14) of one group coincide with the axes of the magnetic elements (11) of the stator, the electromagnets (14) are connected to an electromagnetic energy accumulator (32) and in the absence of coincidence between the magnetic axes (19, 18) of the electromagnets (15) of the second group and the axes of the corresponding magnetic elements (11) of the stator (9) said electromagnets (15) are connected to a controllable voltage unit (36).
Patent DE-69104203-D1 (DE)
Inventor: CLIFT VAUGHAN
IPC: G01N21/31
Filed: 1991-06-06
Granted: 1994-10-27
Abstract: The concentration of a substance, especially glucose, in the blood is measured in vivo by applying to the skin two wavelengths of infrared light and measuring the difference in the absorption of the two wavelengths, preferably in the range of 3-10  mu m, one being a sample wavelength at which the substance shows a specific absorption and the other being a reference wavelength at which the substance shows no specific absorption. Simultaneously the concentrations of interfering components are measured in the same way and the result for the substance is corrected with regard to the measured concentrations of interfering components. Infrared light is transmitted through optical fibres (10, 10a) to a detector having two chambers (15, 15a), a sample wavelength to one chamber (15) and a reference wavelength to the other (15a), and a transducer (14) between the chambers measures the difference in the pressures induced in the respective chambers when the tissue beneath the chambers is heated by absorption of the infrared light transmitted to it.
Patent DE-69104739-D1 (DE)
Inventor: WINKLER DUANE K
IPC: A61M1/00
Filed: 1991-02-04
Granted: 1994-12-01
Abstract: A wound evacuator for extracting body fluids from a patient has end walls (20,22) connected by a side wall (24) to form a cavity (26) for receiving the body fluid. Springs (28) within the cavity bias the end walls (20,22) apart, to expand the cavity (26). One of the end walls (20) has an inlet opening (30) including a one-way check valve (32) through which body fluids can be drawn by the partial vacuum created within the expanding cavity (26). An outlet opening (38) in the end wall (20) has a discharge valve assembly (40) with a valve member (46) which is held against a valve seat (44) by the partial vacuum within the cavity (26), and is moved away from the valve seat (44) when the end walls (20,22) are manually pressed together to cause body fluids in the cavity (26) to be discharged through the valve assembly (40) to a collection bag (18). The valve assembly (40) has an end fitting (52) by means of which the collection bag (18) can be connected to the evacuator. The collection bag (18) has an inlet port (70) with an anti-reflex valve (78). The valve member (46) is freely movable within a passageway (50) in the discharge valve assembly (40), so that after fluid has been discharged from the evacuator to the collection bag (18), when the partial vacuum created within the expanding cavity (26) extends to the anti-reflex valve (78) in the collection bag (18), the valve member (46) is positioned in the passageway (50) away from its seat (44). On separation of the collection bag (18) from the evacuator, the partial vacuum within the cavity (26) draws body fluids from the passageway (50) and the bore (38) in the end fitting (52), before the valve member (46) moves into sealing engagement with the valve seat (44). Leakage of body fluids upon separation of the collection bag (18) is thus substantially reduced. <IMAGE>
Patent DE-69106360-D1 (DE)
Inventor: JANSSENS FRANCINE
IPC: C07C19/08
Filed: 1991-06-04
Granted: 1995-02-09
Abstract: PCT No. PCT/BE91/00034 Sec. 371 Date Dec. 8, 1992 Sec. 102(e) Date Dec. 8, 1992 PCT Filed Jun. 4, 1991 PCT Pub. No. WO91/18852 PCT Pub. Date Dec. 12, 1991.The invention relates to a thermal process the production of 1,1-dichloro-1-fluoroethane by hydrofluorination of vinylidene chloride carried out in the absence of any catalyst.
Patent DE-69111329-D1 (DE)
Inventor: COOL JAN CONSTANT
IPC: A61F2/00
Filed: 1991-07-25
Granted: 1995-08-24
Abstract: Method for correcting the shape of a spinal column. A rod is attached to the vertebrae in the longitudinal direction of the spinal column, at the rear thereof, across the part which is to be corrected. The rod consists of a material, for instance of an Ti-Ni-alloy, with a shape-memory with a transition temperature, lower than the body-temperature. The rod is bent and possibly twisted, corresponding to the curve and/or torsion of the spinal column at a temperature, under the transition-temperature. The rod has a perpendicular cross-section with a linear size in one direction, at least so large, that above the transition-temperature, the rod wants to assume its original shape with a constant force. <IMAGE>
Patent DE-69112863-D1 (DE)
Inventor: BRU-MAGNIEZ NICOLE
IPC: A61P9/10
Filed: 1991-02-15
Granted: 1995-10-19
Abstract: The present invention relates to the derivatives of the formula <IMAGE>  Formula (I)  in which: A is an aromatic ring or a nitrogen heterocycle; X1, X2, X3 and X4 are independently a hydrogen atom, a halogen atom, a lower alkyl radical, a C3-C7 cycloalkyl radical, an alkoxy radical, an alkylthio radical, a sulfone group, SO2-lower alkyl, a sulfoxide group, SO-lower alkyl, a trifluoromethyl group, a nitro group, a hydroxyl group, a methylene alcohol radical or a group COOR', in which R' is a hydrogen or a lower alkyl; X3 and X4 can also form a naphthalene with the phenyl; B is CR5R6, R5 and R6 being a hydrogen atom, a lower alkyl or a C3-C7 cycloalkyl radical, or the sulfur atom; R1, R2, R3 and R4 are independently a hydrogen atom, a lower alkyl radical or a C3-C7 cycloalkyl radical; CR1R2 or CR3R4 can form with B, when the latter is CR5R6, a cycloalkyl or a cycloalkene having 3 to 7 carbon atoms; R1R2 and R3R4 can also form a ring having 3 to 7 carbon atoms; n is an integer from 1 to 4 and can be 0 if R1 and R2 are other than hydrogen; and D is a chemical group which can be: COOR7, R7 being the hydrogen atom, a lower alky radical or a C3-C7 cycloalkyl radical, CONH-R8, R8 being the hydrogen atom, a lower alkyl radical or a C3-C7 cycloalkyl radical, or CN, and to their addition salts. The compounds are thromboxane antagonist receptors.
Patent DE-69121464-D1 (DE)
Inventor: BERGEY JAMES L
IPC: A61K31/19
Filed: 1991-05-10
Granted: 1996-09-26
Abstract: A method is provided for slowing the progression of atherosclerosis in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients by administering a combination of a cholesterol lowering drug such as pravastatin, and an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
Patent DE-69132474-D1 (DE)
Inventor: INOUE SHUNSUKE
IPC: H01L21/3205
Filed: 1991-05-22
Granted: 2000-12-28
Abstract: A wiring forming method for a semiconductor device (104) having a wiring (123) on an insulating film (122) thereof comprises steps of: irradiating an area (106), for forming the wiring (123), of the insulating film (122) with a high energy beam (106); and effecting a deposition process for depositing a conductive metallic substance, thereby selectively depositing the conductive metallic substance on the irradiated area (106). <IMAGE>
Patent DE-69210728-D1 (DE)
Inventor: SCHAPIRA JOSEPH
IPC: C10M173/02
Filed: 1992-09-15
Granted: 1996-06-20
Abstract: Lubricating and disinfecting solution for a receptacle conveyor line in the agri-foodstuffs industry, characterised in that it comprises an effective quantity of at least one ether amine of formulae:  R-O-(CH2)3-NH2 (1> or RO-(CH2)3-NH(CH2)3-NH2 (2> in which R denotes a C6-C21 branched, saturated or unsaturated alkyl chain.
Patent DE-69212671-D1 (DE)
Inventor: WELS WINFRIED STEPHAN DR
IPC: A61K47/48
Filed: 1992-01-27
Granted: 1996-09-19
Abstract: The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.
Patent DE-69217587-D1 (DE)
Inventor: BERTOLA ROBERTO
IPC: B65G33/14
Filed: 1992-06-24
Granted: 1997-04-03
Abstract: A rotary pipe (4) and fixed channel auger (3) with intermediate outer supporting elements (5) comprises alternated portions of a rotary spiral (1), within the fixed outer channel (2) and, respectively, of a fixed spiral (3) clamped within an outer pipe (4) which turns rigidly therewith, the portions of rotary pipe (4) having preferably a like length and bearing on outer supporting elements (5) which substantially comprise pairs of centering rollers (6) connected by shafts (7) which are parallel to the axis of the spiral (3). <IMAGE>
Patent DE-69219306-D1 (DE)
Inventor: TIPTON MARY B
IPC: C08G59/38
Filed: 1992-12-08
Granted: 1997-05-28
Abstract: High solids coating compositions are made from organic solvent solutions of the reaction product of a diglycidyl ether of a dihydric phenol, vernonia oil and a dihydric phenol.
Patent DE-69223424-D1 (DE)
Inventor: HOLMGREN AMBJOERN
IPC: B08B15/00
Filed: 1992-01-28
Granted: 1998-01-15
Abstract: PCT No. PCT/SE92/00051 Sec. 371 Date Nov. 1, 1993 Sec. 102(e) Date Nov. 1, 1993 PCT Filed Jan. 28, 1992 PCT Pub. No. WO92/14561 PCT Pub. Date Mar. 9, 1992An arm (2) on which to mount an extractor and other equipment, the arm (2) is hinged by its inner end (9) to a support (17) with the intermediary of a mounting bracket (14), so as to be allowed to pivot essentially in the horizontal plane. A retaining device (18) acts between the arm (2) and the mounting bracket (14) to retain the arm in the set pivotal position. The retaining device (18) includes a rod (24) which carries friction washers (23) and which may be actuated by an actuator (20) via a rotationally mounted yoke (38) in order to move the friction washers (23) from their retaining frictional engagement with a plate (34) connected to the mounting bracket (14) and thereby allow the arm (2) to be pivoted as desired. The power actuator (20) is remote-controlled by a control unit positioned on the extraction hood of the extractor.
Patent DE-69225334-D1 (DE)
Inventor: KAMINSKY MARK
IPC: C07C5/48
Filed: 1992-12-16
Granted: 1998-06-04
Abstract: An olefins process is described which combines cracking of a hydrocarbon feedstock with the coupling of methane using an oxygen-affording gas such that the heat evolved in the exothermic methane coupling reaction is effectively transferred to the endothermic cracking process in a manner which does not allow the non-hydrocarbon products in the effluent of the methane coupling reaction to mix with the effluent of the cracking process. By combining the cryogenic requirements of the two processes, the refrigeration used in air liquifaction to separate oxygen for the methane coupling process can provide refrigerant nitrogen to liquify one or more of methane, ethylene and propylene which can be used in the cryogenic separation of the C2+ hydrocarbon products in the cracking process effluent.
Patent DE-69228114-D1 (DE)
Inventor: ICHIKI TATSUMI
IPC: C07B61/00
Filed: 1992-09-22
Granted: 1999-02-18
Abstract: In a process for the preparation of  gamma -butyrolactone by catalytically dehydrogenating 1,4-butanediol in a gaseous phase in the presence of a catalyst, reaction is carried out in the presence of a catalyst containing copper and chromium and in the presence of hydrogen, and  gamma -butyrolactone is separated from a reaction mixture and the residual part is recycled as such in a feed. The activity, selectivity or life of the catalyst is not adversely affected by recycled impurities, and some of impurities are decomposed by the catalyst. <IMAGE>
Patent DE-69229269-D1 (DE)
Inventor: ALVAREZ FERNANDO
IPC: A61K38/00
Filed: 1992-06-16
Granted: 1999-07-01
Abstract: PCT No. PCT/FR92/00539 Sec. 371 Date Apr. 18, 1994 Sec. 102(e) Date Apr. 18, 1994 PCT Filed Jun. 16, 1992 PCT Pub. No. WO92/22656 PCT Pub. Date Dec. 23, 1992Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronic viral forms of hepatitis, such as hepatitis C or B. Said human P450 cytochrome peptide fragment contains at least one P450 IID6 cytochrome immunodominant epitope and consists of an amino acid sequence comprising from 3 to 70 amino acids. Said peptide binds specifically with anti-LKM auto-anitbodies produced in autoimmune hepatitis.
Patent DE-69230003-D1 (DE)
Inventor: LEE Len
IPC: A01N43/72
Filed: 1992-11-20
Granted: 1999-10-21
Abstract: The present invention provides novel herbicidal pyridines characterized by having in the 3- or 5-position an aliphatic or aromatic 1-ketone.
Patent DE-69301583-D1 (DE)
Inventor: WAELDE FRANK
IPC: B60R3/02
Filed: 1993-07-01
Granted: 1996-03-28
Abstract: Known sliding steps in the area of roller blinds of fire engines or similar have a locking mechanism with snap pins, cable locking elements, lever systems, etc. and a special control switch. A sliding step (1) for a utility vehicle is proposed which can be locked in the retracted position in which it is not used by closing a vertical roller blind (4). <IMAGE>
Patent DE-69301710-D1 (DE)
Inventor: LUCAS JEAN-PIERRE
IPC: E01C23/22
Filed: 1993-10-13
Granted: 1996-04-11
Abstract: The present invention relates to a line-marking apparatus of the type which is used particularly for marking lines on sports grounds, roads, etc. It comprises, mounted on a chassis (1), a pressurised air tank whose outlet is provided with a pressure reducer (12) and a bottle of paint (15) connected to the output of the pressurised tank.   It is noteworthy in that the said bottle (15) is removably mounted on the said chassis (1), the connection of the bottle (15) to the output of the tank (3) being provided by a dismantleable system, the said bottle (15) carrying a valve system (21) on which a diffuser (23) is mounted. <IMAGE>
Patent DE-69304895-D1 (DE)
Inventor: SUNKARA SAI
IPC: A61K31/4402
Filed: 1993-01-11
Granted: 1996-10-24
Abstract: Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
Patent DE-69319580-D1 (DE)
Inventor: BOND ALEXANDER
IPC: F16L23/024
Filed: 1993-12-02
Granted: 1998-08-13
Abstract: The method of joining a coupling member to a pipe end is described. The method is particularly concerned with providing a coupling member (12) on the end of a pipe (10) of composite construction formed from a plurality of helically wound reinforcement strips of steel. The method comprises the steps of forming at least one generally circumferentially directed groove (20) in the outer surface of the pipe wall adjacent the end of the pipe to a depth extending into the reinforcement core, providing a coupling member adapted to fit the end of the pipe overlapping the region of the groove or groove, providing key (32) means to extend between said sleeve and said groove in said pipe, providing a curable resin (34) in the joint area between said pipe and said sleeve and curing said resin to bond said coupling member to said pipe end. The resultant coupling is of increased efficiency in providing both an adhesively bonded and mechanically coupled joint.
Patent DE-69320938-D1 (DE)
Inventor: KATO KINYA
IPC: C02F3/12
Filed: 1993-10-19
Granted: 1998-10-15
Abstract: There are here provided a method for biodegrading trichloroethylene which comprises the step of bringing an aqueous medium containing trichloroethylene into contact with microorganisms having a trichloroethylene degrading ability derived from intestines of termites to degrade trichloroethylene; a method for obtaining the microorganisms; a method for remediating a soil by the use of the microorganisms; and a method for biodegrading an chlorinated organic compound with the microorganisms. <IMAGE>
Patent DE-69329976-D1 (DE)
Inventor: BRIGHT E
IPC: B65C9/28
Filed: 1993-12-14
Granted: 2001-04-05
Abstract: Apparatus for applying to an article (25) with a long axis a segment (16) of heat-shrinkable sheet material on a circumference (45) of the article around its axis, said circumference having a convex contour (46) along the said axis, said segment having a length direction and a width, a leading end and a trailing end unattached to said leading end, said apparatus comprising an infeed portion (26), a wrapping station; and a heat shrink zone (52) wherein the wrapping station contains a vacuum drum (17) and a roll on pad (31), by means of which a stream of successive said articles and a stream of successive said segments are brought together to apply a said segment to each succeeding article, the articles all the while advancing with rotation, along a path, in a line of advance which is perpendicular to the long axis of the articles, the width of the path corresponding to the dimension of the articles perpendicular to said long axis; and the apparatus being characterised in thatthe separation between the vacuum drum (17) and the roll on pad (31) is smaller than the path width, thereby to reduce said convexity of said article circumference as said segment is wrapped on said article circumference within the wrapping station, by squeezing the article between the roll on pad and the vacuum drum.
Patent DE-69332377-D1 (DE)
Inventor: STOUT JAY
IPC: C07K1/12
Filed: 1993-07-13
Granted: 2002-11-14
Abstract: The present invention provides for a method of preparing a modified recombinantly produced polypeptide including a reactive side chain group and a modified N-terminal  alpha -amine group or C-terminal alpha -carboxyl group, the method comprising the steps of recombinantly forming a polypeptide having a biologically added protecting group on an N-terminal  alpha -amine group or C-terminal alpha -carboxyl group, cleaving the biologically added protecting group with a cleavage reagent to form the unprotected terminal amino acid  alpha -carbon reactive group and modifying the unprotected terminal amino acid  alpha -carbon reactive group with a chemical modifying agent to form a terminally modified polypeptide. The invention further provides for a biologically added protecting group for a recombinantly produced polypeptide comprising a peptide or amino acid, said biologically protecting group being stable under conditions for chemical protecting reactions and including an enzymatic cleavage recognition site and a chemical cleavage recognition site, wherein the recognition sites are not present in the recombinantly produced polypeptide.
Patent DE-69332903-D1 (DE)
Inventor: REMAKRISHNAN KASTOORIRANGANATH
IPC: G01N33/58
Filed: 1993-08-19
Granted: 2003-05-28
Abstract: A unique class of chemiluminescent labels containing biotin substitution that are suitable for chemiluminescent assays using inter alia a streptavidin and/or avidin conjugate. The chemiluminescent labels of the invention have the ability to bind to streptavidin and/or avidin per se or to streptavidin and/or avidin conjugated with an analyte. Label structures are disclosed that have hydrolytic stability to meet the most demanding commercial assay conditions. The invention encompasses conjugates containing associated versions of the labeling compounds, assays and kits for performing such assay utilizing the conjugates.
Patent DE-69409641-D1 (DE)
Inventor: DIONNE Craig
IPC: C07D487/14
Filed: 1994-05-27
Granted: 1998-05-20
Abstract: The invention relates to novel indolocarbazole derivatives, eg. of formula III <CHEM>       (wherein: R<1> is selected from the group consisting of halogen, CH2OCONHR<14> and NHCO2R<14>; R<2> is selected from the group consisting of hydrogen and halogen;   X is selected from the group consisting of CO2CH3, CH2OH and CONHR<15>;   R<14> represents lower alkyl; and R<15> is hydrogen, hydroxy substituted lower alkyl, or aryl; with the proviso that when R<1> = halogen and R<2> = hydrogen, X is neither CO2CH3 nor CH2OH; and with the proviso that when R<1> = R<2> = halogen, X is not CO2CH3; and with the proviso that when R<1> = R<2> = Br, X is not CONHC6H5) which are useful in the treatment of pathological conditions of the prostate gland.