baber/WOPTO huggingface dataset:
Patent WO-2020264220-A1 (WO)
Title: Detection and treatment of residual disease using circulating tumor dna analysis
Inventor: MURTAZA MUHAMMED
IPC: G16H50/30
Filed: 2020-06-25
Abstract: The present disclosure provides a method of treating a cancer in a patient who has undergone a first anti-cancer therapy. Also provided is a method for monitoring treatment response and minimum residual disease in a neoadjuvantly treated cancer patient. Methods for primer design are also disclosed. The present disclosure provides several tools for increasing the sensitivity and analytical precision of the disclosed methods for monitoring ctDNA.
Patent WO-2021003398-A1 (WO)
Inventor: PINKERTON ANTHONY B
IPC: A61P3/10
Filed: 2020-07-02
Abstract: Les protéines tyrosine phosphatases (PTP) sont des régulateurs clés du métabolisme et de la signalisation de l'insuline. En tant que régulateur négatif de la signalisation de l'insuline, la protéine tyrosine phosphatase de faible poids moléculaire (LMPTP) est une cible pour l'insulinorésistance et des affections associées. L'invention concerne des composés capables de moduler le niveau d'activité de la LMPTP, des compositions et des procédés d'utilisation de ces composés et compositions.
Patent WO-2021030025-A1 (WO)
Inventor: FETTY MARK W K
IPC: F16C35/06
Filed: 2020-07-23
Abstract: In one aspect, a seal case is provided for a roller bearing assembly having a central axis. The seal case includes an annular first end section including a rim configured to engage an outer ring, an intermediate section including a radial wall extending inwardly from the first end section and an axial wall extending axially away from the radial wall and the first end section, and an annular second end section extending radially inward from the axial wall of the intermediate section. The seal case further includes an insert of the first end section made of a first material. The first end section and the radial wall of the intermediate section include a second material joined to the insert. The first material of the insert may be selected to provide improved durability and/or to resist expansion and contraction of the first end section caused by changes in temperature.
Patent WO-2021025876-A1 (WO)
Inventor: CHIMMALGI ANANT
IPC: B33Y30/00
Filed: 2020-07-24
Abstract: An additive manufacturing apparatus (10) includes (a) a light polymerizable resin unit comprising a surface on which a light polymerizable resin can be supported; (b) a light engine (17) configured to illuminate a region of the light polymerizable resin unit; (c) a carrier platform on which an object can be produced; (d) a drive assembly operatively associated with the carrier platform for advancing said carrier platform (12) and said light polymerizable resin unit away from one another as said object is produced; (e) a purge chamber (300) surrounding at least a portion of said light engine (17); and (f) a purge gas in said purge chamber, or a purge gas supply operatively associated with said purge chamber (300).
Patent WO-2021021806-A1 (WO)
Inventor: ZHAN GUODONG
IPC: C22C26/00
Filed: 2020-07-28
Abstract: Systems and methods include a computer-implemented method for manufacturing a binder for spraying onto tools. A binder is manufactured for binding compacts onto a tool substrate. The binder is designed to provide a coating strength on the tool substrate. The binder includes: a metal selected from iron (Fe), cobalt (Co), and nickel (Ni); an alloy including the metal selected from Fe, Co, and Ni; or a refractory alloy selected from tungsten, tantalum (Ta), molybdenum (Mo), and niobium (Nb). An ultra-high-pressure, high-temperature operation is performed on pure wurtzite boron nitride (w-BN) powder to synthesize w-BN and cubic boron nitride (c-BN) compact. A binder-compact mixture is produced by turbulently mixing the binder with the compact in a mixer within a vacuum. The binder-compact mixture is thermally sprayed onto a tool substrate to coat the tool.
Patent WO-2021025992-A1 (WO)
Inventor: FARRELL DAVID J
IPC: A61M25/00
Filed: 2020-07-31
Abstract: A catheter drainage member (112) configured to be attached to a catheter tube (116), the drainage member comprising: a body (115) having an inner surface (114); a well (120) defined by the inner surface of the body, the well configured to receive the catheter tube and an adhesive (122); and wherein the well is configured to selectively distribute the adhesive between the inner surface and the tube.
Patent WO-2021133435-A1 (WO)
Title: Procédé et appareil d'élimination d'impuretés dans des charges de biomasse solide
Inventor: COIL GREGORY
IPC: C10B53/02
Filed: 2020-08-13
Abstract: L'invention concerne des procédés d'élimination des impuretés contenues dans une biomasse solide tout en préservant les teneurs en hydrogène et en carbone. L'invention concerne des exemples de procédés mettant en œuvre des solutions aqueuses acidifiées dans un procédé d'extraction à contre-courant qui comprend le transport pneumatique de boues entre des unités de traitement, ou une étape de déshydratation mécanique, ou les deux, pour produire une biomasse lavée convenant à divers procédés de valorisation et de conversion.
Patent WO-2021041456-A1 (WO)
Title: Methods and systems of organic semiconducting polymers
Inventor: PAN HUALONG
IPC: H01L51/30
Filed: 2020-08-26
Abstract: A method of reacting bis(R1) 5,5"'-dibromo-3",4'-difluoro-[2,2':5',2":5",2"'-quaterthiophene]- 3,3"'-dicarboxylate and bis(R2) 5,5'"-dibromo-3",4'-difluoro-[2,2':5',2":5",2'"-quaterthiophene]- 3,3"'-dicarboxylate to form the polymer: Formula (I) In this polymer R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: a halogen, a substituted alkyl, an unsubstituted alkyl, a substituted aryl, an unsubstituted aryl, a substituted heteroaryl and an unsubstituted heteroaryl.
Patent WO-2021041809-A1 (WO)
Inventor: CHNG CHINPING
IPC: C12N9/20
Filed: 2020-08-28
Abstract: La présente invention concerne des polypeptides de lipase modifiés et des compositions de ceux-ci. Les polypeptides de lipase modifiés ont été optimisés pour fournir une thermostabilité, une stabilité de protéase et une stabilité améliorées dans une plage de conditions de pH, comprenant des conditions acides (pH <7) et basiques (pH >7). L'invention concerne également l'utilisation des compositions comprenant les polypeptides de lipase modifiés à des fins thérapeutiques et/ou nutritionnelles. La présente invention concerne également des polynucléotides codant pour les polypeptides de lipase modifiés, ainsi que des procédés de fabrication des polynucléotides modifiés et des polypeptides de lipase.
Patent WO-2021055437-A1 (WO)
Title: Cd70 targeted chimeric antigen receptor (car) t cells and uses thereof
Inventor: LEICK MARK
IPC: C07K14/725
Filed: 2020-09-16
Abstract: Provided herein are CD70 targeting chimeric antigen receptors and engineered immune cells (e.g., T cells) comprising such CAR. Method of treating a cancer expressing CD70 using such engineered immune cells are also provided. In some embodiments, the method of treating cancer further comprising using an agent that enhances CD70 expression in the cancer (e.g., azacitidine) in combination with the engineered immune cells comprising the CD70-targeting CAR.
Patent WO-2021055722-A1 (WO)
Title: System and method for application tamper discovery
Inventor: WHITMORE JON
IPC: G06F21/55
Filed: 2020-09-18
Abstract: A system and method for early detection of a compromised client device includes a tamper detection service configured to monitor modifications to resource access privileges over time to identify unusual variations in jailbreak status that indicate compromise of the client device. For example, the tamper detection service may monitor the jailbreak status of system files over time to expose attempts to hide the jailbreak status of a protected resource. To validate that malware is attempting to hide the jailbreak status of a protected resources, the tamper detection process may launch multiple different resource accesses, targeting the protected resource, to determine whether different accessibility results are returned, indicating a compromised device.
Patent WO-2022075990-A1 (WO)
Title: Documents en réalité augmentée
Inventor: SCHMIDT WAYNE J
IPC: G06T11/80
Filed: 2020-10-08
Abstract: Selon des mises en œuvre illustratives, l'invention concerne des documents en réalité augmentée. Par exemple, des modes de réalisation peuvent comprendre un dispositif qui comprend un affichage à réalité augmentée, et un dispositif informatique, comprenant une ressource de mémoire non transitoire stockant des instructions lisibles par machine stockées sur celle-ci qui, lorsqu'elles sont exécutées, font effectuer les opérations suivantes par une ressource de processeur : déterminer des dimensions d'un support positionné en vue de l'affichage à réalité augmentée, et produire une image d'un document numérique en utilisant les dimensions déterminées sur l'affichage à réalité augmentée de sorte que l'image soit fixée au support.
Patent WO-2022010520-A1 (WO)
Title: Methods of producing hydrocracking catalyst
Inventor: KOSEOGLU OMER REFA
IPC: C10G47/18
Filed: 2020-11-03
Abstract: A method for producing a hydrocracking catalyst includes preparing a framework substituted Y-type zeolite, preparing a binder, co-mulling the framework substituted Y-type zeolite, the binder, and one or more hydrogenative metal components to form a catalyst precursor, and calcining the catalyst precursor to generate the hydrocracking catalyst. The framework substituted Y-type zeolite is prepared by calcining a Y-type zeolite at 500? to 700? to form a calcined Y-type zeolite. The framework substituted Y-type zeolite is prepared by forming a suspension containing the calcined Y-type zeolite, the suspension having a liquid to solid mass ratio of 5 to 15, adding acid to adjust the pH of the suspension to less than 2.0, adding and mixing one or more of a zirconium compound, a hafnium compound, or a titanium compound to the suspension, and neutralizing the pH of the suspension to obtain the framework substituted Y-type zeolite.
Patent WO-2021126704-A1 (WO)
Title: System and method applied to integrated development environment
Inventor: JIANG LONG
IPC: G06F9/44
Filed: 2020-12-11
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining a network service and applicable to an integrated development environment (IDE) are provided. The IDE comprises a graphical interface comprising a toolbar and a plurality of functional areas, the plurality of functional areas comprise a code editing area for inputting and outputting source code, and the toolbar comprises an icon. One of the methods includes: receiving a user operation on the icon in the toolbar; and in response to the user operation on the icon being a preset user operation, loading a browser engine, and displaying, through the browser engine, a navigation interface corresponding to the icon in the code editing area of the graphical interface of the IDE, for a user to obtain a network service corresponding to the navigation interface.
Patent WO-2021150643-A1 (WO)
Title: Vessel gripper
Inventor: WHITE STEPHEN
IPC: B25J15/10
Filed: 2021-01-20
Abstract: A gripper provides for gripping labware having a variety of diameters and shapes. The gripper includes a support structure having a center axis, a motor, and a gripper stage. The gripper stage includes a plurality of blades, each of the blades having a) a first end through which a blade rotation axis extends, the blade rotation axis being fixed relative to the support structure and offset from the center axis, b) a second end that is circumferentially and radially moveable to rotate the blade about the blade rotation axis, and c) a center portion. The gripper stage also includes a ring structure coupled to the motor to rotate the ring structure around the center axis. The ring structure, as it rotates, moves the second end of each blade to rotate the blade about the blade rotation axis of the blade to shift the center portion towards the center axis to contact an outer portion of a vessel extending along the center axis.
Patent WO-2021150728-A1 (WO)
Title: Airbag chute panel and method of manufacturing the same
Inventor: HARRIS BRADLEY
IPC: B60R21/235
Filed: 2021-01-21
Abstract: A method of manufacturing a chute panel of an airbag assembly. The method comprises forming a substrate from a first material to have a body having first and second ends and a longitudinal axis extending therebetween and a void residing in the body. The method further comprises forming a chute and a chute door from a second material. The chute comprises a base molded onto the substrate body and one or more sidewalls extending from the base. And wherein forming the chute door comprises filling the void in the substrate body with the second material to form the chute door.
Patent WO-2021162942-A1 (WO)
Title: 7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide compounds
Inventor: BLEISCH THOMAS JOHN
IPC: A61K31/519
Filed: 2021-02-05
Abstract: The present invention provides a compound of Formula (I) wherein R is (II), (III), (IV) or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.
Patent WO-2021162955-A1 (WO)
Title: Methods and apparatuses for a new radio, nr, layer-two-relay
Inventor: DAMNJANOVIC JELENA
IPC: H04W76/15
Filed: 2021-02-05
Abstract: Techniques for a new radio layer two relay are disclosed. A base station configures (706) a user equipment, UE, and a relay UE having individual direct communication links with the base station (702, 704) to configure a sidelink communication link between the UE and the relay UE. The sidelink communication link allows the UE to communicate with the base station via the direct communication link between the base station and the UE and the sidelink communication link between the UE and the relay UE (708).
Patent WO-2021163631-A1 (WO)
Title: Calpain-2 inhibitor compounds and methods of treatment
Inventor: BAUDRY MICHEL
IPC: A61K31/17
Filed: 2021-02-12
Abstract: Compounds of Formula (I) or (X) are provided including for treatment of disorders such as a disorder or symptom associated with neuronal cell death. In one aspect, compounds which are selective inhibitors of calpain-2 are provided. Preferred compounds can be useful to treat acute neurodegeneration.
Patent WO-2021178246-A1 (WO)
Title: Régulation de vecteur génique au moyen de micro-arn exprimés par des cardiomyocytes
Inventor: LOMBARDI LAURA
IPC: A61K35/76
Filed: 2021-02-26
Abstract: La présente invention concerne des vecteurs et leur procédé d'utilisation, pour la répression spécifique de type cellulaire d'expression de transgènes (par exemple, des facteurs de reprogrammation de cardiomyocytes) à l'aide de sites de liaison de microARN.<i />
Patent WO-2021183909-A1 (WO)
Title: Wearable autotensioning device
Inventor: ROVEKAMP ROGER
IPC: A44C5/22
Filed: 2021-03-12
Abstract: An apparatus for automatically adjusting tension on a retention member and thereby applying compression or other forces to an object. Sensors may be used to sense changes associated with the object involved or the environment, and an actuator may be included that automatically rotates a rotating member such as a gear or pulley to automatically adjust tension on the retention member. The adjustments in tension may be made performed automatically and many times per second based on control signals from control logic responsive to the sensors.
Patent WO-2021188422-A1 (WO)
Title: Chuck assembly for a medical device
Inventor: SWEITZER ZACHARY
IPC: A61B17/16
Filed: 2021-03-15
Abstract: A chuck assembly for a medical device is provided. The chuck assembly includes a mounting base structured to couple to a tool; a housing coupled to the mounting base; and a cam sleeve within the housing and movable with respect to the housing between a locked position and an unlocked position, the cam sleeve having an annular base, an arm extending from the annular base, and a cam extending laterally from the arm.
Patent WO-2021188614-A1 (WO)
Title: Composition, methods of making and using for treating a viral infection, including coronavirus infection
Inventor: CI ZHONGHUA
IPC: A61P31/14
Filed: 2021-03-17
Abstract: A composition from Traditional Chinese Medicine (TCM) ingredients makes it possible to treat those infected with a virus, including, e.g., coronavirus or the flu, including but not limited to COVID-19 or Influenza A ("FluA"). Although makeable by other methods, the composition is makeable from a decoction of the TCM ingredients. Although usable for other purposes, the composition may be used to treat a patient in need of treatment for a virus, e.g., coronavirus infection, such as COVID-19 infection, or, e.g., the flu, such as FluA, by administering to the patient an effective amount of the composition.
Patent WO-2021188729-A1 (WO)
Title: Compositions and methods for the targeting of c9orf72
Inventor: OAKES BENJAMIN
IPC: C12N9/22
Filed: 2021-03-17
Abstract: Provided herein are Class 2 Type V systems comprising nucleases, guide nucleic acids (gNA), and optionally donor template nucleic acids useful in the modification of a  C9orf72  gene. The systems are also useful for introduction into cells, for example eukaryotic cells having mutations or duplications in the  C9orf72  gene. Also provided are methods of using such systems to modify cells having such mutations or duplications.
Patent WO-2021202485-A1 (WO)
Title: Compositions comprising romp catalyst and dispersant, cartridges, and methods
Inventor: KROPP MICHAEL A
IPC: G03F7/029
Filed: 2021-03-30
Abstract: A composition is described comprising a ring opening metathesis polymerization catalyst or precatalyst thereof; and an unreactive dispersant having a viscosity at 25 °C of at least 10 Pa· sec at a shear rate of 1 1/sec. Also described is a cartridge (e.g. for a dispensing and mixing apparatus) comprising such composition. The cartridge typically comprises a first chamber comprising unpolymerized cyclic olefin; and a second chamber comprising the catalyst and dispersant. Also described are compositions including two-part compositions and methods of bonding a substrate.
Patent WO-2021211601-A1 (WO)
Title: Embossed film assembly having pastel holographic security features
Inventor: DESCHNER MATTHEW
IPC: G02B5/18
Filed: 2021-04-13
Abstract: An embossed film assembly is provided that includes a substrate and at least one security layer formed from a polymer layer having an image formed therein and a high refractive index (HRI) layer on the polymer layer. The polymer layer and the HRI layer form a holographic security feature on the substrate. The image in the polymer layer is formed from low frequency gratings configured to generate a pastel color in the holographic security feature.
Patent WO-2021252134-A1 (WO)
Title: Reactive flame retardants for flexible polyurethane foams
Inventor: STOWELL JEFFREY
IPC: C08G18/18
Filed: 2021-05-14
Abstract: The present invention provides reactive multi-functional dialkyl phosphinate compound(s), serving as highly efficient reactive flame retardants in flexible polyurethane foams. The invention further provides fire-retarded polyurethane compositions comprising said multi-functional dialkyl phosphinate compound and applications containing the same.
Patent WO-2021247246-A1 (WO)
Inventor: JOHNSON LANNY LEO
IPC: A01C21/00
Filed: 2021-05-20
Abstract: Fertilizer compositions containing protocatechuic acid are provided. Such fertilizer compositions may be used to fertilize plants or plant seeds. The use of such fertilizer compositions to fertilize plants or plant seeds can provide benefits to the plants, e.g., enhanced plant growth, less browning, greater pest resistance, and better flowering, as well as health benefits to consumers of those plants.
Patent WO-2021247600-A1 (WO)
Inventor: LECLERE THEODORE
IPC: A61M1/00
Filed: 2021-06-01
Abstract: The present disclosure is directed to a modular, multi-specialty pump system. The pump system includes a pump console with a motor and a sensor and a removable pump cassette attached to the pump console. The pump cassette includes a cassette identifier and the sensor can detect the cassette identifier and adjust at least one operating parameter of the motor depending on the detected cassette identifier of the pump cassette.
Patent WO-2022255999-A1 (WO)
Inventor: BUTTLER MARC ALLAN
IPC: G01F25/10
Filed: 2021-06-02
Abstract: L'invention concerne une électronique de mesure (20) pour sélectionner un critère de vérification zéro pour effectuer une vérification zéro d'un appareil de mesure vibratoire (5). L'électronique de compteur (20) comprend une interface (401) couplée en communication à un ensemble capteur (10) contenant un fluide et un système de traitement (402) couplé en communication à l'interface (401). Le système de traitement (402) est configuré pour déterminer une propriété d'un fluide et sélectionner, sur la base de la propriété du fluide, la valeur de critère de vérification zéro pour l'ensemble capteur (10).
Patent WO-2022250712-A1 (WO)
Title: Élimination d'impuretés de sable dans un traitement humide
Inventor: LI CHUNLI
IPC: B03B7/00
Filed: 2021-06-07
Abstract: La présente invention concerne des procédés et des systèmes de traitement de sable extrait pour éliminer une impureté selon la divulgation. Un procédé donné à titre d'exemple consiste à fournir du sable extrait contenant l'impureté, à mettre en contact le sable extrait avec un fluide de traitement aqueux comprenant un alcool éthoxylé et un dérivé d'acide sulfonique, et à sécher le sable extrait ; au moins une partie de l'impureté étant retirée du sable extrait séché après contact du sable extrait avec le fluide de traitement aqueux.
Patent WO-2021257966-A1 (WO)
Inventor: MALHOTRA SANJAY
IPC: C09B29/36
Filed: 2021-06-18
Abstract: La présente divulgation concerne de manière générale des composés appropriés en tant qu'inhibiteurs d'ERG, y compris des compositions comprenant de tels composés, des méthodes pour leur utilisation dans le traitement de maladies associées à la surexpression de la protéine ERG de type sauvage, une protéine ERG modifiée, la transcription du gène ERG ou la traduction d'ARNm ERG, et des procédés de préparation de tels composés.
Patent WO-2021262789-A1 (WO)
Inventor: FURMAN ADAM
IPC: H04R25/00
Filed: 2021-06-23
Abstract: Various aspects include approaches for managing tinnitus in a user. In some particular aspects, a computer-implemented method of managing tinnitus of a user with at least one wearable device includes: actuating, according to a prescribed pattern and using the at least one wearable device: a) an electro-acoustic transducer to provide an audio output to the user, and b) a contact element to apply vibration to a body part of the user, where the prescribed pattern both stimulates the nervous system of the user and delivers a sound to the user, which together mitigate the tinnitus.
Patent WO-2022231639-A1 (WO)
Inventor: ALSTAD HÅVARD
IPC: G06F13/40
Filed: 2021-07-13
Abstract: L'invention concerne des appareils destinés à adapter des connexions USB, Thunderbolt, et similaires à une connexion Ethernet avec une alimentation électrique multiplexe dynamique. Les appareils selon la présente invention permettent de relier et d'alimenter un dispositif périphérique par le biais de son port Ethernet depuis une connexion USB, Thunderbolt, ou similaire d'un ordinateur hôte. Un multiplexeur de puissance est utilisé en conjonction avec un circuit de détection de courant et un bloc logique d'activation de PoE pour produire et réguler l'alimentation électrique multiplexe dynamique à partir d'une multiplicité de sources d'énergie incluant une connexion externe de courant continu et une connexion USB ou Thunderbolt depuis un ordinateur hôte.