Patent SG-11201407548U-A (SG)
Title: Treatment of amd using aav sflt-1
Inventor: CONSTABLE IAN J
IPC: A61K39/00
Filed: 2013-05-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOIPCT (10) International Publication Number WO 2013/173129 A3 (51) International Patent Classification: A61K 48/00 (2006.01) C12N15/86 (2006.01) C12N15/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/647,461 61/670,535 61/678,555 61/691,660 61/775,440 15 May 2012 (15.05.2012) 11 July 2012 (11.07.2012) 1 August 2012 (01.08.2012) 21 August 2012 (21.08.2012) 8 March 2013 (08.03.2013) PCT/US2013/040011 7 May 2013 (07.05.2013) English English US US us us us (71) Applicants (for all designated States except US): AVA­ LANCHE AUSTRALIA PTY LTD. [AU/AU]; c/o MPR Group Pty Ltd., Floor 19, Building HWT Tower, 40 City Road, Southbank, Victoria, 3006 (AU). LIONS EYE IN­ STITUTE LIMITED [AU/AU]; 2 Verdun Street, Ned- lands, Western Australia, 6009 (AU). (72) Inventors; and (71) Applicants (for US only)-. CONSTABLE, Ian, J. [AU/AU]; 134 Glyde Street, Mosman Park, Western Aus­ tralia, 6012 (AU). RAKOCZY, Elizabeth, P. [AU/AU]; M405/183 West Coast Hwy, Scarborough, Western Aus­ tralia, 6019 (AU). LAI, Chooi-may [AU/AU]; 27 Kildenny Circle, Waterford, Western Australia, 6152 (AU). CHALBERG, Thomas, W., Jr. [US/US]; 2749 Carolina Avenue, Redwood City, CA 94028 (US). (74) Agents: ORBAI, Lucian et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] (54) Title: TREATMENT OF AMD USING AAV SFLT-1 o\ CJ T-H m i> a SB! Oats o am WMhiffl :: December Ml: wjm : Sasetee • &4IPV mm Oayai 472\m uim Day 30 498 fan 1 jylrr *** fjl fjl 1 jylrr *** Day 69 593 \*m wjrn 0<tyS 0 : Silpffl:: tam FIG. 16 T-H o CJ O (57) Abstract: The present disclosure provides compositions and methods for the prevention or treatment of ocular neovasculariza­ tion, such as AMD, in human subject, a by administering subretinally pharmaceutical composition comprising pharmaceutically a a effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase- (sFlt-1) protein 1 to the human subject. WO 2013/173129 A3 I lllll llllllll II llllll III lllll lllll III III III lllll llll lllll lllll lllll lllll lllllll llll llll llll TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 30 January 2014