baber/WOPTO huggingface dataset:
Patent IL-164323-A0 (IL)
Title: Heteroaryl compounds which inhibit leukocyte adhesion mediated by aipha-4 integrins
IPC: A61P19/02
Filed: 2004-09-28
Abstract: Disclosed are compounds which bind alpha<SUB>4 </SUB>integrins, where the alpha<SUB>4 </SUB>integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by alpha<SUB>4 </SUB>integrins, where the alpha<SUB>4 </SUB>integrin is preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Patent IL-172993-A0 (IL)
Title: Thiazolo-,oxazalo and imidazolo-quinazoline compounds capable of inhibiting protein kinases
IPC: A61P25/00
Filed: 2006-01-05
Abstract: A compound of formula 1, or a pharmaceutically acceptable salt thereof, wherein: X is S, O, or NH; "a" is a single bond; or "a" is a double bond and one of R3 and R4, and one of R5 and R6 are absent; R1 is H; or is selected from an alkyl group, a cycloalkyl group, a heteroaryl group, an aralkyl group, CO-alkyl, SO2-alkyl, CO2R13 and an aryl group, each of which optionally contains one or more heteroatoms, and is optionally substituted with one or more groups selected from R8 and R9; R2 is H, R8, or an alkyl group optionally substituted with one or more R8 groups; R3, R4, R5, and R6 are each independently selected from H, R8, an alkyl group and an alkenyl group, wherein said alkyl and alkenyl groups are optionally substituted with one or more R8 groups; or R3 and R4, and/or R5 and R6 together represent -O; R7 is H, R8, NH(CH2)nR9, CO(CH2)nR9, NHCO(CH2)nR9, O(CH2)nR9, or an alkyl or phenyl group, each of which is optionally substituted with one or more groups selected from R8 and R9; R8 is OR10, NR10R11, halogen, CF3, NO2, COR10, CN, COOR10, CONR10R11, SO2R10 or SO2NR10R11; R9 is a saturated or unsaturated 5- or 6-membered cyclic group optionally containing one or more heteroatoms selected from N, O and S, and optionally substituted with one or more R8 groups; R10, R11, R12 and R13 are each independently H or a hydrocarbyl group; and n is 0, 1, 2 or 3. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula 1, and the therapeutic use thereof in the treatment of proliferative disorders, viral disorders, CNS disorders, diabetes, stroke and cardiovascular disorders.
Patent IL-176898-A0 (IL)
Title: Growth factor-binding compounds and methods of use
IPC: A61K31/195
Filed: 2006-07-17
Abstract: Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.
Patent IL-213543-A0 (IL)
Title: Insect protection fabric
IPC: D04H3/045
Filed: 2011-06-14
Abstract: The insect safety device has a mounting plate mountable before an opening and insect protection fabric (12), which has chaining yarn (16) and filling yarn (18) connected with one another in lattice-like manner. The chaining yarn and filling yarn runs in a separate thread level one above the other. An independent claim is also included for a method for production of an insect protection fabric for an insect safety device.
Patent RO-127170-A0 (RO)
Title: Process for obtaining a resorbable material of beta-phosphate tricalcium
Inventor: GRIGORE FLORENTINA
IPC: A61L27/12
Filed: 2011-04-19
Abstract: The invention relates to a process for preparing a material with regenerative properties, used as bone substitute material in the orthopedic and oral and maxillofacial surgery. The claimed material is prepared by carrying out, in a first step, a porous ceramic structure of β -TCP, by precipitating in distilled water solutions of 30% concentration of ammonium hydrogen phosphate and calcium nitrate tetrahydrate at 38°C, for 60 min, while stirring at 800 rpm, at a controlled pH of 8...8.5, filtering, washing and drying for 12 h in a cabinet dryer, followed by calcining at 800°C for 2 h and preparing a ceramic suspension with a solid content of 75% by homogenization with sodium polyacrylate and polyethylene oxide, impregnating a polyurethane foam, drying, sintering and sterilizing the resulting porous ceramic structure, then, in a second step, the ceramic structure is screened on sieves with meshes of 45...125 μm, 125...250 μm, 500...1000 μm and 1000...2000 μm, there resulting a reproducible material of resorbable β -TCP as four size-types, with apparent densities within the range of 1.186...0.7905 g/cm.
Patent RO-130536-A0 (RO)
Title: Multi-wire corona electrode
Inventor: PLEŞA CĂLIN AUREL
IPC: H01T19/00
Filed: 2015-01-19
Abstract: The invention relates to a multi-wire corona electrode used in the installations for separating, in intense electric field, the materials with different electric conductivities from granular mixtures. According to the invention, the electrode comprises some active electrodes () mounted on an active plate (), the so-formed assembly being supported by another plate () provided with a fixing support (), where the first active electrode () is fixed in a central position on the active plate (), and the other active electrodes () are symmetrically mounted in relation to the first fixed electrode (), the distance between the active electrodes () being adjustable due to their slide in some channels () or in some elongated holes () made in the active plate ().
Patent AU-2003904207-A0 (AU)
Title: Enhancement of sound externalization and separation for hearing-impaired listeners: a spatial hearing-aid
IPC: G10L21/00
Filed: 2003-08-11
Abstract: A method of enhancing sound heard by a hearing-impaired listener comprises monitoring the sound in an environment in which the listener is located; and manipulating the frequency of high frequency components of the sound in a high frequency band, with little, if any, distortion to components of the sound in a speech frequency band, to enhance spectral cues to aid the listener in sound externalisation and spatialisation.
Patent LU-70543-A1 (LU)
IPC: F27D21/02
Filed: 1974-07-16
Abstract: An air-cooled refractory guide tube for insertion in the wall of a metallurgical furnace to permit reciprocal movement of an elongated rod-shaped member into and out of the interior of the furnace through a central orifice extending through the tube. The guide tube consists of a metal part and a refractory part, with the metal part including means for directing compressed air through the central orifice of the refractory part and for independently directing air through a series of cooling orifices extending through the ceramic part. Upon the ceramic part being consumed in use, the metal part can be reused. By controlling the rate of flow of cooling air through the ceramic part, its melting rate can be kept equal to that of the furnace wall.
Patent MA-27684-A1 (MA)
Title: Preparation et utilisation de derives d'imidazole dans le traitement de l'obesite
Inventor: SMITH ROGER A
IPC: A61P3/06
Filed: 2004-04-23
Abstract: La présente invention concerne des dérivés imidazoles substitués dont il a été avéré qu'ils suppriment l'appétit et induisent une perte de poids. L'invention fournit également des méthodes de synthèse des composés, des compositions pharmaceutiques comprenant les composés, et des méthodes d'utilisation de ces compositions en vue d'induire une perte de poids et traiter l'obésité et les troubles liés à l'obésité.
Patent MA-27894-A1 (MA)
Inventor: THYSELL HAKAN
IPC: B24D7/06
Filed: 2006-01-05
Abstract: The invention concerns a carrier plate holding an abrading element, for detachable mounting on a rotatably mounted abrading plate driven during use, for abrading stone or concrete floors, which carrier plate has sides which form an acute angle with each other. The sides have flanges which are formed for surrounding engagement with a shoulder arranged on the abrading plate so that the carrier plate can be fixed on the abrading plate with an engagement based on form and friction.
Patent MA-38941-A1 (MA)
Title: Systeme embarque pour extraire et transmettre les signatures vibratoires relatives au defauts de roulement dans une eolienne
Inventor: EL YOUSFI ALAOUI HICHAM
IPC: G01M15/12
Filed: 2016-03-31
Abstract: La présente invention permet d'extraire et de transmettre les signaux vibratoires relatifs aux défauts de roulement de ceux acquis par un accéléromètre monté sur la structure d'une machine électrique. Cette solution permet d'éliminer les signaux non utiles à la source, de réduire la quantité de données transmise et traitée. Ce qui augmente la vitesse et l'efficacité du traitement. Ce circuit s'installe sur la machine à surveiller, reçoit les signaux captés par l'accéléromètre, les traite et les met à la disposition d'un émetteur sans fils. Ce qui offre une solution adaptée à la surveillance des machines mobiles ou à accès difficile comme dans le cas des éoliennes.
Patent UY-27665-A1 (UY)
Title: Nuevos derivados de piridina y pirimidina
Inventor: LOEFFLER BERND MICHAEL
IPC: A61K31/4418
Filed: 2003-02-12
Abstract: La presente invención se refiere a compuestos de la fórmula (I) donde R1, R2, R3 y X son tal como se definen en la descripción y reivindicaciones, y sales farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento y/o prevención de enfermedades que están asociadas con DPP IV, como diabetes, particularmente diabetes mellitus no dependiente de insulina, y disminución de la tolerancia a la glucosa.
Patent UY-28068-A1 (UY)
Title: Benzoxazinonas sustituidas y usos de las mismas
Inventor: MAAG HANS
Filed: 2003-11-06
Abstract: La invención proporciona un compuesto de fórmula: y sales o pro-fármacos farmacéuticamente aceptables del mismo, en donde Y,Z,R1, R2, R3, R4, R5, R6, R7, R8, R9, m, n, p y q son tal como se definen aquí. La invención también proporciona métodos para la preparación, composiciones que lo comprenden, y métodos para el uso de compuestos de Fórmula I.
Patent UY-29824-A1 (UY)
Title: Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios
Inventor: BLIXT JORGEN
IPC: C07D401/12
Filed: 2006-09-29
Abstract: La presente invención se refiere a procedimientos químicos para la fabricación de ciertos derivados de quinazolina, o sales farmacéuticamente aceptables de los mismos. La invención también se refiere un procedimientos para la fabricación de ciertos compuestos intermedios útiles en la fabricación de los derivados de quinazolina y un procedimientos para la fabricación de los derivados de quinazolina utilizando dichos compuestos intermedios. En particular, la presente invención se refiere un procedimientos químicos y compuestos intermedios útiles en la fabricación del compuesto 4-(4-bromo-2-fluoroanilino)-6-metoxi-7-(1-metilpiperidin-4-ilmetoxi)quinazolina.
Patent UY-30520-A1 (UY)
Title: Compuestos de pirimidina
Inventor: MARIANNA DR VRETTOU
IPC: A61K31/506
Filed: 2007-08-02
Abstract: La presente invencion se refiere al uso de compuestos de pirimidina de la formula I en donde las variables tienen los significados indicados en las reivindicaciones y en la descripcion, para combatir hongos daninos, a nuevos compuestos de pirimidina de la formula I y a los agentes fungicidas y farmacéuticos que los contienen.
Patent ES-149345-A1 (ES)
Title: UN DISPOSITIVO AUTOMáTICO PARA RELLENAR EL MOLDE DE PRENSAS DE RESINA ARTIFICIAL
IPC: B29C31/06
Filed: 1940-05-01
Abstract: La propiedad y explotación exclusivas de un dispositivo automático para llenado de los moldes de la prensa de resina artificialconsistente en una corredera de llenado cuyas aberturas se llena periódicamente de material para prensarprocedente de un depósitoque vacían a continuación en el moldecaracterizado por el hecho de estar unída elásticamente la corredera de llenado (22) con una placa de cierre inferiormente dispuesta (21)con la cual es guiada de modo que la placa de cierre (21) se queda atrás con respecto a la corredera de llenado (22) cuando ésta se encuentra encima del molde (12) y por quedar ambas partes fuera del contacto directo con las partes calentadastambién durante dicha operación de llenado.
Patent ES-172511-A1 (ES)
Title: Perfeccionamientos en los dispositivos de seguridad para trenes de laminaje
IPC: B21B33/00
Filed: 1946-02-09
Abstract: Perfeccionamientos en los dispositivos de seguridad para trenes de laminaje caracterizándose porque está constituido por un cuerpo hueco que encierra unas bolas sobre las que se ejerce la presión del laminado y que tiene una abertura lateral normalmente cerrada por la cual una vez destapada en caso de necesidad pueden salir las bolas permitiendo de este modo disminuir la presión que se ejerce sobre ellas.
Patent ES-179408-A1 (ES)
Title: UN DISPOSITIVO PARA MáQUINAS DE CALCULAR
Filed: 1947-08-20
Abstract: Tiene un mecanismo de regulación que puede efectuar rotaciones en los dos sentidos, por ejemplo, un tambor con rueda de trinquete, caracterizado por ejemplo, un tambor con rueda de trinquete, caracterizado por la presencia de una palanca de mando que puede ser regulada en tres posiciones diferentes y con ayuda de la cual la máquina puede regularse para una división y una multiplicación completamente automática con embrague a la derecha y a la izquierda respectivamente del mecanismo de regulación.
Patent ES-182349-A1 (ES)
Title: MEJORAS EN SISTEMAS DE COMUNICACIoN MULTICANAL
IPC: H04J7/00
Filed: 1948-02-13
Abstract: Mejoras en sistemas de comunicación multicanal en dos sentidos para comunicar sobre un tren multicanal de impulsos modulados en tiempo a dos terminales en dos sentidos opuestos incluyendo cada uno caracterizados porque comprenden un modulador de tren de impulsos multicanal, siendo un demodulador al impulso multicanal, siendo dicho modulador y dicho demodulador del tipo de tubo de rayos catódicos y medios para controlar la sincronización de dichos dos terminales.
Patent ES-194805-A1 (ES)
Title: BOMBA ROTATIVA A BAJA VELOCIDAD PARA EL TRASIEGO DE LiQUIDOS
Filed: 1950-09-29
Abstract: Bomba rotativa a baja velocidad para el trasiego de líquidos que comprende una cámara anular interrumpida en un punto entre dos aberturas correspondientes a la impulsión y a la aspiración de la bomba en cuyo interior gira según su plano medio o de simetría un rodete constituido por un disco de forma anular que pasa formando constantemente cierre a través de una ranura o paso de dicha interrupción de la cámara y que está provisto de dos o más muescas en las que pueden girar sendas paletas las cuales en determinados puntos del giro del rodete pasan alternativamente de la posición coincidente con el plano del disco a la posición perpendicular a dicho plano en que forman cierre con las paredes interiores de la cámara.
Patent ES-196751-A1 (ES)
Title: MEJORAS INTRODUCIDAS EN LA CONSTRUCCIoN DE BOMBAS PULVERIZADORAS PORTáTILES
Filed: 1951-02-28
Abstract: Mejoras introducidas en la construcción de bombas pulverizadoras portátiles para toda clase de líquidos pulverizables caracterizadas por el montaje peculiar y concatenado en un vehículo de transporte adecuado de unas bombas aspirantes e impelentes gemelas con su accionamiento; de una campana neumática neutralizadora de los golpes de pistón y aseguradora de la emisión de un chorro pulverizado continuo; de una válvula de seguridad; de un indicador de presión; de un grifo de interrupción a la salida de la campana; de una manguera flexible con lanza y pulverizador-eyector a su final; de un depósito del líquido a esparcir con dos batideras accionadas desde el accionamiento general y con dispositivo de salida del líquido en la parte central de su fondo.
Patent ES-267185-A1 (ES)
Title: Barium titanium borate, pigments containing the same, and processes for their production
IPC: C09C1/36
Filed: 1961-05-05
Abstract: A barium titanium borate compound BaO,TiO2,B2O3 is prepared by heating a mixture of either (1) titanium dioxide and barium metaborate or a mixture of barium and boron compounds convertible to barium metaborate by heating e.g. barium sulphide, carbonate or hydroxide with boron trioxide or boric acid, or (2) barium titanate and boron trioxide or a boron compound convertible to the trioxide upon heating. The titanium dioxide content of the resulting product does not exceed 26,4% by weight. The heating is carried out between 700 DEG -1300 DEG C. for 10 mins.-24 hours. The titanium dioxide used may be anatase, rutile and titanium dioxide ores or it may be prepared by precipitation in the hydrous form from titanium tetrachloride or sulphate solutions e.g. titanium tetrachloride may be added dropwise to crushed ice in a bath after which aqueous ammonia is added and the whole maintained at 10 DEG -20 DEG C. until no further precipitation occurs. The barium metaborate may be precipitated by reacting solutions of barium sulphide or hydroxide with sodium tetraborate. Example 1 refers to the above stoiciometric quantities of barium carbonate, boric acid and hydrous titanium dioxide being ground in a mortar and pestle and fired at 1100 DEG C. for 1 hour. X-ray analysis of the resulting crystalline product indicated that a compound had been formed. Example 3 refers to equal molar quantities barium sulphide in solution and titanium dioxide together with an amount of borax equivalent to half the molar quantity of the barium sulphide, being refluxed for 4 hours. The resulting mass was dried at 140 DEG -150 DEG C., ground and fired at 900 DEG C. for 2-3 hours. Specifications 813,228 and 879,499 are referred to.
Patent ES-271787-A1 (ES)
Title: Substituted 2-p-aminobenzensulphonamido-pyrazines
IPC: C07D241/22
Filed: 1961-11-06
Abstract: The invention comprises compounds of general formula <FORM:0981096/C2/1> wherein R is OCH3 or Cl and (1) the preparation of 3,5-dichloro-2-p-aminobenzenesulphonamidopyrazine by treating 2,3,5-trichloropyrazine with sulphanilamide at from 80 DEG to 150 DEG C. in the presence of an acid acceptor, and (2) the preparation of 5 - chloro - 3 - methoxy - 2 - p - aminobenzenesulphonamidopyrazin either by treating the corresponding 3,5-dichloro compound with an alkali metal salt of methanol in methanolic solution at 40-120 DEG C. for 2-20 hours, or by condensing the corresponding 2-amino compound with a p-acylamino-benzene-sulphohalide in the presence of a tertiary-amine and subsequently hydrolysing with alkali the acyl group in the N4-position of the sulphanilamide group of the intermediate (e.g. 2-(p-acetylaminobenzenesulphonamido) - 5 - chloro - 3 - methoxy-pyrazine) also the preparation of 3 - methoxy - 2 - p - aminobenzenesulphonamido-pyrazine by catalytically hydrogenating the 5-chloro compound, prepared as above, in the presence of an acid acceptor and the compounds so prepared. Therapeutic compositions comprise a compound of, or obtained by a process of, the invention, together with a pharmacologically acceptable carrier. The compounds have bacteriostatic activity. Specifications 928,151 and 981,097 are referred to.
Patent ES-347191-A1 (ES)
Title: Improvements in sealing ball valves
IPC: F16K5/06
Filed: 1967-11-15
Abstract: In a ball valve 10, having a cylindrical steel housing 11 within which there is disposed a ball valve member 14, sealing of the ball with respect to the housing is effected by means of annular steel seating rings 15 each of which carries an annular sealing ring 17 and is biased on to the ball by a stressed annular resilient backing ring 20, both the sealing and backing rings being made of P.T.F.E. The backing rings 20, when in the unstressed condition, are of parallelogram shape but can be compressed to square section either by the inlet pressure acting on the upstream seating ring 15, or by thermal expansion of the sealing and seating rings, ineither of which cases the downstream seating ring abuts the adjacent housing end wall, (Fig. 3, not shown).
Patent ES-361431-A1 (ES)
Title: Phenylethanolamine Derivatives Effective in the Treatment of Bronchospastic Conditions
IPC: B61D7/00
Filed: 1968-12-14
Abstract: Compounds of the general formula (R = tert.-butyl, cyclobutyl, cyclopentyl R5 = OH, C 1-5 alkanoyloxy) and their salts are prepared by (a) reducing a compound of the formula (R3 = H or group replaceable by H) in the presence of RNH 2 , followed by replacement of R3 if necessary (b) reacting a compound of the formula with RR4NH (R4=H, aralkyl), followed by replacement of R3'4, if necessary (c) reducing a compound of the formula followed by replacement of R3'4 if necessary or (d) hydrogenating a compound of the formula reacting the product with cyclobutanone or cyclopentanone, further hydrogenating the reaction mixture and replacing R3 if necessary optionally followed in each case by salt formation. The preparation of starting materials for processes (a), (b), (c) and (d) by standard methods and of ethyl 3,5-dihydroxybenzoate, 3,5- dibenzyloxybenzoic acid, 3,5-dibenzyloxybenzoyl chloride, 3,5 - dibenzyloxy - # - bromoacetophenone, 3,5 - dibenzyloxy - # - chloroacetophenone and 3,5-dibenzyloxyacetophenone is described. The compounds of the invention are bronchodilators, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Patent ES-362014-A1 (ES)
Title: Instrument using intermediate storage for reproducing pre-recorded information
IPC: G09B5/06
Filed: 1968-12-31
Abstract: Information is retrieved from a prerecorded medium 17 by moving an instrument at an arbitrary speed over the medium to pick up the information and transfer it to an intermediate store in the instrument. The information is subsequently played back from the intermediate store at a speed substantially equal to the original recording speed of the medium 17. As shown, the prerecorded medium 17 is in the form of strips of magnetic tape incorporated in the pages of a book with corrugations 20, Fig. 5, to guide the reading instrument. This contains, Fig. 1, a pick-up head 7 connected through an amplifier to a record/playback head 15 which co-operates, together with an erase head 16, with a magnetic coating 2 on an endless belt 5 of rubber or the like which is driven directly or indirectly (Figs. 2, 2a and 4) by friction with the tape 17 as the instrument is moved along the tape. The recording circuit is completed by closure of resilient switch contacts (19, Figs. 3 and 6) when the reading instrument is pressed against the tape 17. Insertion of the instrument into a playback unit 33, Fig. 5, actuates other switches (39, 42, 44, 47, Fig. 6) to complete .a playback circuit, including a loud-speaker 49, and set in motion a wheel (45, Figs. 4 and 6) which drives the intermediate storage belt 5 at a speed substantially the same as that at which the tape 17 was driven during the original recording process.
Patent ES-366832-A1 (ES)
Title: Alkaline cleansing composition
IPC: C11D3/36
Filed: 1969-05-06
Abstract: A method of preventing the formation of deposits from hard water comprises adding thereto a phosphoric acid of the Formula (I) in which n is 0 or 1, or an alkali metal salt of such a phosphonic acid compound. Additives specified are caustic alkalis, alkali metal carbonates, alkali metal phosphates, alkali metal borates, alkali metal silicates, wetting agent, and defoaming agent.