baber/WOPTO huggingface dataset:
Patent CA-2561826-A1 (CA)
Title: Linear single chain recombinant anti-cea/cd3/cd28 trispecific antibody
Inventor: ZHAO BAOFENG
IPC: C12N15/70
Filed: 2005-03-29
Abstract: This invention refers to a linear single chain recombinant trispecific antibody (scTsAb). This trispecific antibody is composed of an anti-carcinoembryonic antigen (CEA), an anti-CD3, and an anti-CD28 (CEA-scTsAb). More specifically, a Fc linking peptide fuses the anti-CEA single chain fragment (scFv) to the anti-CD3 scFv, and an HSA linking peptide fuses the anti CD3 scFv to the anti-CD28 heavy variable chain (V H) in tandem. A c-myc-tag and/or (His) 6-tag is attached to the C terminal of the CEA-scTsAb either alternatively or simultaneously. This invention also refers DNA sequence coding for the said scTsAbs, plasmids containing the said sequences, and host cells containing the said plasmids. These invented scTsAbs are intended for use in the development of therapeutic drug candidate for treatment of human colon cancer.
Patent CA-2563033-A1 (CA)
Title: Novel gamma secretase inhibitors
Inventor: JOSIEN HUBERT B
IPC: C07D487/08
Filed: 2005-04-04
Abstract: Gamma-secretase inhibitors of the formula: Chemical formula should be inserted here as it appears on the abstract in paper form. are useful in treating various neurodegenerative diseases, wherein, for example: R1 includes unsubstituted or substituted aryl or heteroaryl groups; R2 includes -C(O)-Y, alkylene-C(O)-Y, alkylene-cycloalkylene-C(O)-Y, cycloalkylene-alkylene-C(O)-Y, alkylene cycloalkylene-alkylene-C(O)-Y, cycloalkylene-C(O)-Y, -S(O)-Y, alkylene-S(O)-Y, alkylene-cycloalkylene-S(O)-Y, cycloalkylene-alkylene-S(O)-Y, alkylene cycloalkylene-alkylene-S(O)-Y, cycloalkylene-S(O)-Y, -S(O2)-Y, alkylene-S(O2)-Y, alkylene cycloalkylene S(O2)-Y, cycloalkylene alkylene S(O2)-Y, alkylene cycloalkylene-alkylene-S(O2)-Y, and cycloalkylene-S(O2)-Y, wherein Y is as defined herein, and each of said alkylene or cycloalkylene may be unsubstituted or substituted as provided herein; each R3 is independently includes H, alkyl, O alkyl, OH, N(R9)2, acyl, and aroyl; or the moiety (R3)2, together with the ring carbon atom to which it is shown attached in formula I, defines a carbonyl group, -C(O)-; each R3A and R3B independently includes H, or alkyl; R11 includes aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. One or more of the compounds of formula I, or pharmaceutically acceptable salts, solvates, and/or esters, or compositions comprised thereof, may be used to treat, e.g., Alzheimer's Disease.
Patent CA-2565411-A1 (CA)
Title: Compounds and methods for inhibiting mitotic progression
Inventor: WEATHERHEAD GABRIEL S
IPC: A61K31/55
Filed: 2005-05-12
Abstract: This invention relates to compounds and methods for the treatment of cancer.  In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
Patent CA-2568078-A1 (CA)
Title: Telescopic table support
Inventor: PICCHIO CESARE
IPC: A47B9/20
Filed: 2006-11-14
Abstract: A telescopic support is disclosed and has outer and inner leg parts. The outer leg part has: a tubular body defining a longitudinal axis and having an interior passage through which the axis extends centrally. The inner leg part has: a shuttle body part disposed at least partially in the tubular body; and rollers rotably mounted to the shuttle body to support the inner leg part for longitudinal reciprocating movement in the tubular body. The support can be secured to a base and topped with a work-surface defining member to form a height--adjustable table, as also disclosed.
Patent CA-2568874-A1 (CA)
Title: Compression anastomosis device
Inventor: FOWLER DAVID
IPC: A61B17/11
Filed: 2006-11-24
Abstract: An anastomotic device surgically joins the free ends of a first and a second tubular structure. The device generally includes two ring members, each of which is secured to a free end of the tubular structure. Each ring member includes an outer portion and an inner portion.  The outer portions are each cylindrical and ring-like with open ends. The length of the cylindrical outer portions provides support for the portions of the tubular structures near and adjacent the ends of the tubular structure, thus reducing the likelihood of stricture during healing of the anastomotic tissue. Outer portions have holes around their perimeters which provide a scaffold for tissue to grow through for increasing the strength of the tissue near the anastomosis.  The inner portions have connecting means and are designed to matingly engage one another.
Patent CA-2569251-A1 (CA)
Title: Hemostasis valve and method for assembling same
Inventor: GADBERRY DONALD L
IPC: F16K7/06
Filed: 2005-05-24
Abstract: The invention is directed to a sealing apparatus for sealing around a medical instrument, the sealing apparatus comprising a housing body (110); a two-piece cam (120) body; a sealing member (32) having a channel, the sealing member having at least two protrusions (30); a plurality of pins (26) to radially compress the sealing member against and form a seal around the medical instrument; and biasing means for compressing the sealing member. The biasing means includes a first finger tab, a second finger tab. The second finger tab extending laterally from the housing body in apposition to the first finger tab, and a spring (28) to normally force the finger tabs apart. In another aspect, a process of assembling the sealing apparatus of the invention is disclosed.
Patent CA-2574489-A1 (CA)
Title: Medical devices and materials containing isobutylene copolymer
Inventor: RICHARD ROBERT E
IPC: A61M25/10
Filed: 2005-07-19
Abstract: The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.
Patent CA-2577491-A1 (CA)
Title: Systeme de guidage et de securite destine aux systemes de circulation complexes
Inventor: RAUCH JUERGEN
IPC: G08G1/127
Filed: 2005-08-18
Abstract: La présente invention concerne un système de guidage et de sécurité destiné à un moyen de transport, notamment un moyen de transport en commun complexe. Un dispositif de comptage automatique de passagers ; un dispositif de surveillance de sécurité, par exemple, en prévention d'incendie, de criminalité et de terrorisme ; un dispositif de commande de l'utilisation de composants individuels du système de transport comme de véhicules, trains etc. et un dispositif de surveillance automatique de parcours et d'informations sur les passagers par un squelette technico-éléctronique sont reliés ensemble. Les fonctions partielles du système pouvant être cobminées entièrement ou partiellement au système utilisent, de préférence, ces mêmes lignes de données. D'autres éléments comme un dispositif de contrôle d'accès aux moyens de transport avec biométrie, un dispositif de suivi de trajets de passagers, un dispositif de guidage automatique de l'évacuation (par exemple en cas d'incendie et de catastrophe) des véhicules, trains ou de l'infrastructure construite, un dispositif de surveillance automatique d'itinéraire, un dispositif empêchant l'entrée de personnes dans les zones nécessaires au fonctionnement etc. mais aussi chaque type d'information sur les passagers comme la publicité et autre peuvent être suspendus au système de guidage et de sécurité. Ce système comprend au moins un moyen de guidage (24, 26, 28, 60) destiné au moins à un moyen de transport (14) et/ou aux personnes, plusieurs unités de détection (40, 42, 44) et une unité centrale (20). L'unité centrale (20) est reliée aux unités de détection (40, 42, 44) et au moyen de guidage (24, 26, 28, 60). Les unités de détection (40, 42, 44) permettent de déterminer le nombre de personnes se trouvant à un moment donné dans une zone spatialement déterminée de telle façon que l'unité centrale (20) puisse en conséquence commander le guidage (60) pour automatiquement mettre à disposition le nombre de véhicules adéquat à la fréquence nécessaire et guider les passagers aux accès des véhicules. En outre le passage de circulation est sécurité. En cas de bouchon, le véhicule est automatiquement commandé et éventuellement mis à l'arrêt. Une communication de données avec le dispositif de commande du moyen de transport a lieu de telle façon qu'en cas de besoin, des unités moyens de transport puissent être ajoutées ou retirées du système pour garantir une utilisation des moyens de transport en fonction des besoins et garantir une grande efficacité de l'infrastructure de circulation. Lors d'une commande automatique du moyen de transport, ce renforcement ou cette réduction automatique s'effectue automatiquement (sans intervention humaine).
Patent CA-2579424-A1 (CA)
Inventor: WRIGHT ERIK
IPC: G06Q30/06
Filed: 2007-02-22
Abstract: A method and system for delivering value added service (VAS) applications offered by a service provider to a subscribing end user is presented. The method includes collecting, by a user service module, end user device information, forwarding, by the service provider, end user information, to a server, creating, by the service provider, target end user profiles, VAS application campaigns, and campaign schedules, and storing the same in the server. The method further comprises communicating, between the server and the user service module, to display an offer in the end user device for at least one of the VAS applications, in accordance with the target profiles, the application campaigns, and schedules, wherein, upon selecting by the user, the at least one of the VAS applications is loaded, installed, and activated in the end user device without further end user actions.
Patent CA-2580023-A1 (CA)
Title: Method and apparatus for sampling and analysis of fluids
Inventor: CASSELLS JOHN MACLAREN
IPC: A61B5/00
Filed: 2005-09-13
Abstract: A medical device having a housing (2) with a bore (3) and a lancet (1) slidably fitting in the bore. The lancet operates as a positive displacement piston. In a retracted position, in which the lancet is rearwardly displaced along the bore to define a fluid-containing space in the bore forwardly on the lancet tip, the fluid-containing space has a cross-section dimension to allow fluid to be retained therein by surface tension. The device has a seal (6) operable substantially to prevent flow of fluid from the fluid-containing space past the seal means on movement of the lancet. Displacement of the lancet between the puncture and retracted positions provides suction for drawing fluid into and along the fluid-containing space from the forward end of the bore, and/or pressure for expelling fluid from the fluid-containing space via the forward end of the bore. Also disclosed are methods for operating the device.
Patent CA-2580179-A1 (CA)
Title: Turbine exhaust strut airfoil profile
Inventor: EL-FOULY MONA
IPC: F02K1/78
Filed: 2007-03-02
Abstract: A turbine exhaust thin strut includes an airfoil section having a profile substantially in accordance with at least an intermediate portion of the Cartesian coordinate values of X, Y and Z set forth in Table 2. The X and Y values are distances, which when smoothly connected by an appropriate continuing curve, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form a complete airfoil shape.
Patent CA-2581272-A1 (CA)
Inventor: LEVY ELAD
IPC: A61F2/06
Filed: 2005-09-20
Abstract: A stent (10) for application within an aneurysm (12) the stent (10) comprising an elongated tubular member having a proximal end (36) and a distal end (38).  The stent has a proximal portion (36) expandable from a first diameter to a second diameter. The distal end (38) of the stent (10) may be expandable to a third diameter, which third diameter is larger than the second diameter. The stent (10) may be left disposed across the neck of the aneurysm.
Patent CA-2582535-A1 (CA)
Title: Bag making machine
Inventor: TOTANI MIKIO
IPC: B31B50/20
Filed: 2004-12-20
Abstract: A bag making machine for producing plastic bags by processing plastic films by a processing device, wherein it is intended to accurately process plastic films, to protect the processing device from damage, and to save the required time while decreasing the processing rate as little as possible. A driving mechanism is connected to a processing device to drive the latter. Further, a control device is connected to the driving mechanism. After acceleration (.alpha.1) of the driving mechanism, the mechanism is once decelerated (.beta.1). At the start of the processing of plastic films, the processing device is driven at a low speed (V2). Further, as the processing proceeds, the driving mechanism is reaccelerated (.alpha.2) to drive the processing device at a high speed (V3).
Patent CA-2583107-A1 (CA)
Inventor: GAGNON FREDERIC
IPC: F16H48/20
Filed: 2007-03-30
Abstract: Actionneur différentiel mécanique pour interaction avec une charge mécanique comprenant les éléments suivants : un premier transducteur, un second transducteur, et un différentiel mécanique muni de trois ports d'interaction. Ces trois ports comprennent un premier port d'interaction branché au premier transducteur, un second port d'interaction branché au second transducteur et un troisième port d'interaction branché à la charge. Une méthode d'actionnement d'une charge mécanique est également comprise. La méthode comprend la fourniture d'un différentiel mécanique muni de trois ports d'interaction, d'un premier transducteur, d'un second transducteur; le branchement du premier transducteur au premier port d'interaction du différentiel mécanique; le branchement du second transducteur au second port d'interaction du différentiel mécanique; et le branchement de la charge au troisième port d'interaction du différentiel mécanique.
Patent CA-2583566-A1 (CA)
Title: Rotary bag machine
Inventor: SELLE PAUL
IPC: B31B50/94
Filed: 2005-10-13
Abstract: A rotary bag machine and method for making bags from a film are disclosed.  They include a rotary drum, an accumulation nip, a blanket that positions the film against the drum, and a blanket tensioner located away from the accumulation nip. The drum includes at least one seal bar mounted thereon, and the accumulation nip provides the film to the drum. Various aspects include the accumulation nip being in a fixed position independent of changes of the drum diameter, and/or the path from the accumulation nip to the drum being fixed in length, independent of changes of the drum diameter. An accumulation sensor and a controller that controls the accumulation nip speed and the drum speed in response to the sensor are provided in one embodiment. The speed control is in response to the speed of the film, the rate of change of a function of the input, response history, and/or a setpoint, in various alternatives. A drawtape module and a powered unwind are disposed in a single module with the rotary drum, in another embodiment. A registration mark sensor is located upstream of the accumulation nip, along a path having a fixed length to the drum, in another embodiment. The sensor may be a print sensor.
Patent CA-2583629-A1 (CA)
Title: Method and apparatus for pumping wells with a sealing fluid displacement device
Inventor: REITZ DONALD D
IPC: E21B43/16
Filed: 2004-05-20
Abstract: Liquid is lifted from a well by a fluid displacement device moves within a production tubing and which maintains a seal against the production tubing during movement. The fluid displacement device is moved up and down within the production tubing between the well bottom and the earth surface by applying gas to create opposite relative pressure differentials across the fluid displacement device. Preferably the pressure differential is obtained from gas supplied from the well of supplied at natural formation pressure.
Patent CA-2584376-A1 (CA)
Title: Embeddable polarimetric fiber optic sensor and method for monitoring of structures
Inventor: WILLIAMS JEFFERY LEE
IPC: G01B9/02
Filed: 2005-10-17
Abstract: The present invention provides the capability of ascertaining, through a quick and simple measurement, locations on a structure that may have experienced damage that could result in reduced structure lifetime, strength, or reliability. The sensing element is a connected section of polarization maintaining ("PM") optical fiber, where a length of PM fiber represents a fully distributed sensor array. Stress-induced changes to the sensor are measured through white-light Polarimetric interferometry. The output of the measurement is a data array representing the stress concentration magnitude at an array of locations along the length of the sensor. In an application, the knowledge of the optical fiber position on the structure, coupled with the measurement of stress locations along the fiber length, allows the user to determine locations on the structure with large stress concentrations. These locations may signify structural damage.
Patent CA-2584918-A1 (CA)
Title: Cyanothiophenes, the production thereof and their use as medicaments
Inventor: WALTER RAINER
IPC: A61P3/10
Filed: 2005-10-18
Abstract: The invention relates to cyanothiophenes of general formula (I), in which the R's are defined in the claims, and relates to their tautomers, stereoisomers, mixtures and salts that have valuable pharmacological properties, in particular, a glucagon receptor-antagonistic action.
Patent CA-2585668-A1 (CA)
Inventor: PHILLIPS BENGIE T
IPC: H01R13/629
Filed: 2007-04-19
Abstract: An electrical cord assembly (10) configured for use with an electrical appliance includes a cord (12, 52) having a polygonal end (16, 56) with a first pair of cord sides (18, 60) and a second pair of cord sides (20, 62), wherein one of the pairs of first and second cord sides is asymmetrical, a socket (14, 54) defining a polygonal opening (22, 58) constructed and arranged for receiving the polygonal end (16, 56), the polygonal opening having a first pair of socket sides (24, 64) and a second pair of socket sides (26, 66), wherein one of the pairs of first and second socket sides is asymmetrical, and wherein the polygonal end (16, 56) and the polygonal opening (22, 58) are shaped for releasable mating engagement.
Patent CA-2586577-A1 (CA)
Inventor: COYNE JOSEPH M
IPC: F16L55/165
Filed: 2005-11-02
Abstract: A process for lining an existing pipeline or conduit with a flexible resin impregnated cured in place liner by pulling in the liner and inflating a resin impregnated inflation bladder with air and curing the liner with flow-through steam without loss of pressure is provided. The liner includes a resin absorbent material in tubular form with an impermeable membrane forming an outer layer. The inflation bladder also includes a resin absorbent material in tubular form with an impermeable membrane forming an outer layer and an exhaust assembly at the trailing end and is passed through a pressurized inversion apparatus into the collapsed liner. As the bladder reaches the distal end, the exhaust assembly exits the everting bladder and is coupled to an exhaust hose. Steam is then introduced the inversion apparatus to cure the resin and is exhausted through the exhaust tube. After cure, steam is replaced with air to cool the liner and the ends are cut to restore service through the host pipe.
Patent CA-2588354-A1 (CA)
Title: Electrophoretic display and method for displaying images
Inventor: YANG SAN-MING
IPC: G02F1/167
Filed: 2007-05-11
Abstract: A method of displaying an image in an electrophoretic display device includes charging each of the sets of differently colored particles to have a different charge through application of an electric field to the display fluid or the device, and then applying an electric field to selected ones of the multiplicity of reservoirs to effect movement of one or more of the differently colored sets of particles in the display fluid therein to display a desired color derived from among the sets of differently colored particles. The device may include at least one display layer, including a multiplicity of individual reservoirs containing a display fluid, between conductive substrates, at least one of which is transparent and thus may be a viewing side substrate, wherein the display fluid includes at least two sets of particles in a liquid medium, the at least two sets of particles exhibiting a different color.
Patent CA-2593279-A1 (CA)
Inventor: BAKER GEOFFREY JAMES
IPC: F16L37/138
Filed: 2006-01-17
Abstract: The present invention is concerned with a connector and in particular a connector capable of connecting both male to male and female to female parts .  The present invention thus provides a connector part (30) including a body-portion (31) and at least one arm (40) that projects from an end of the body-portion (31) , the or each arm (40) being arranged such that the connector part (30) can be mated with another, substantially identical connector part (39) , so that the or each arm of the connector part (30) interposes the or each arm of the respective other connector part (30) , wherein the first-connector part (30) has engagement means (33) operable to be releasably engaged by the or each arm (40) of the substantially identical connector part, thereby fixing it relative to the first-said connector part.
Patent CA-2593438-A1 (CA)
Title: Holster for hand held electronic device
Inventor: MAK-FAN DAVID J
IPC: H04M1/7246
Filed: 2007-07-11
Abstract: The holster (1) has one or more magnets (4, 4', 4") positioned so that a Hall effect sensor (3) in the handheld device (2) detects a magnet both when partially inserted in the holster and when fully holstered, thereby enabling desired elements of the device to be disabled from the beginning of the holstering process, to avoid accidental keystrokes or triggering of other input elements such as a trackball. The holster may have separate magnets (4, 4') to accomplish this, or an elongated single magnet (4"). The holster may have a fold-over closure flap (10) with a metallic element (11) aligning with the magnet to also secure the flap.
Patent CA-2593618-A1 (CA)
Title: Derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
Inventor: BERTHELOT PASCAL
IPC: C07C231/20
Filed: 2007-06-29
Abstract: Composés de formule (I) : (voir formule I) Médicaments.
Patent CA-2594654-A1 (CA)
Title: N-((2z)-2-((4-hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide crystalline form 2
Inventor: HENRY RODGER F
IPC: A61K31/44
Filed: 2006-01-13
Abstract: N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.
Patent CA-2596560-A1 (CA)
Inventor: NIXON DONALD RAY
IPC: A61B3/14
Filed: 2007-08-20
Abstract: This invention provides a system to determine the relative Grade or severity of cataracts in the human eye, on an objective and reproducible basis. Using the Pentacam by Oculus a 3 dimensional imaging of the anterior segment is generated. With a dilated pupil a portion of the lens can be visualized and imaged for evaluation. A unique 3 dimensional shape then can be positioned in the lens and the mean optical density of the specific volume can be calculated. Using differences in optical density a Grading of Cataract is generated.
Patent CA-2597458-A1 (CA)
Inventor: GRIFFIN LINNARD
IPC: C01B3/08
Filed: 2006-02-16
Abstract: Disclosed herein is an apparatus, mixture and method for the production of hydrogen comprising a solution with a pH less than 7, at least one colloidal metal suspended in the solution, and a second metal.