Patent GB-1001477-A (GB)
Title: Process for the production of epoxy ethers
IPC: B01J19/18
Filed: 1962-08-03
Abstract: Epoxy ethers and, as intermediates, hydroxyhalopolyethers are obtained by the reaction of an epoxy-alkyl halide, as hereafter defined, with a hydroxy compound in the presence of an acidic catalyst in a reactor having a plurality of reaction stages by continuously feeding the hydroxy compound into the first stage together with part of the epoxyalkyl halide and at least a substantial part of the catalyst, the remaining epoxyalkyl halide and catalyst being added to at least one other stage as the reaction mixture passes through a series of reaction stages without backmixing at a temperature of 70-200 DEG  C. and with a contact time of 60-2 minutes, the hydroxy-halo ether being subsequently dehydrohalogenated. The epoxyalkyl halide is defined as an alkane chain or cycloalkane ring carrying an epoxy group and having a halogen atom attached to a carbon atom which is adjacent to a carbon atom of the oxirane ring; the preferred compound is epichlorohydrin. Specified catalysts are boron trifluoride, or complexes thereof, tin tetrachloride and sulphuric and phosphoric acids.  Polymeric products, e.g. polyepichlorohydrin, are obtained by using excess of the epoxy compound, e.g. 5-100 moles of epichlorohydrin per hydroxy group, over the hydroxy compound, e.g. water or a polyhydric alcohol. Polyepoxy ethers are obtained using polyhydroxy reactants and, e.g. 0.6-1.4 moles epichlorohydrin per hydroxy group.  Dehydrohalogenation is effected using the conventional alkaline and basic reagents.  All or part of the halohydrin groups may be converted to epoxy groups, depending on the amount of dehydrohalogenating agent used.  An example describes the reaction of epichlorohydrin and glycerin use BF3 catalyst and dehydrohalogenation to a glycidyl ether. Suitable apparatus for the process is illustrated in an accompanying drawing.ALSO:Epoxy ethers are prepared by the reaction of an epoxy-alkyl halide, as defined hereafter, with a hydroxy compound in the presence of an acidic catalyst in a reactor possessing a plurality of reaction stages by continuously feeding the hydroxy compound into the first stage together with part of the epoxyalkyl halide and at least a substantial part of the catalyst, the remaining epoxyalkyl halide and catalyst being added to at least one other stage as the reaction mixture passes through a series of reaction stages without backmixing at a temperature of 70-200 DEG  C. and with a contact time of 60-2 minutes, the hydroxyhaloether being subsequently dehydrohalogenated.  The epoxyhalide is defined as an aliphatic chain or ring carrying an epoxy group and a halogen atom attached to a carbon atom which is adjacent to a carbon atom of the oxirane ring, e.g. epichlorohydrin, epibromohydrin, 1-iodo-2,3-epoxyhexane, 1 - chloro - 2,3 - epoxycyclohexane and 2-chloro-2-methyl-3,4-epoxypentane. In the preparation of the mono-epoxy ethers, mono-hydroxy hydrocarbons are used, e.g. methanol, butanol, cyclohexanol, phenol, cresols, naphthol, allyl alcohol and propargyl alcohol, preferably in the molar ratio 4: 1 of epoxyhalide to hydroxy compound.  Polyglycidyl ethers are obtained by dehydrohalogenating the product resulting from the reaction of a polyhydric alcohol with epichlorohydrin. Suitable alcohols are glycerin, ethylene glycol, propylene glycol and pentacrythritol and the preferred ratios are 0.95-1.08 moles of epichlorohydrin per hydroxy group.  Higher ratios, preferably 8: 1 to 12: 1 of epichlorohydrin to hydroxy group, result in the formation polyepichlorohydrins when the polyhydroxy compounds act as initiators.  The preferred catalyst is BF3 or complexes thereof; other suitable acidic catalysts are stannic chloride and sulphuric and phosphoric acids. Dehydrohalogenation may be carried out by conventional methods, using alkaline and basic reagents.  All or part of the halohydrin groups may be converted to epoxy groups.  The multistage reactor can have from 2 to 10 or more reaction stages each of which is supplied by valved individual feed-lines for introducing the catalyst and epoxyhalide and provided with a means of agitation and an independent means of heat transfer.  By virtue of the individually controlled flow of epoxyhalide and catalyst to the reaction stages the course of the reaction can be directed towards particular products. Suitable apparatus is illustrated in accompanying drawings.  In the example a condensation product of epichlorohydrin and glycerin is obtained using BF3 gas as the catalyst and dehydrohalogenating to the glycidyl ether. The composition of the product is varied by using different temperatures and contact times.