Patent SG-11201805831R-A (SG)
Title: Neutralization of inhibitory pathways in lymphocytes
Inventor: ANDRE PASCALE
IPC: C07K16/28
Filed: 2017-01-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111011110111011001011111101111011111 International Bureau .... ....... (10) International Publication Number (43) International Publication Date WO 2017/125532 Al 27 July 2017 (27.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/EP2017/051153 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 20 January 2017 (20.01.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 62/281,217 21 January 2016 (21.01.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: INNATE PHARMA [FR/FR]; 117 Avenue de kind of regional protection available): ARIPO (BW, GH, Luminy, 13009 Marseille (FR). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: ANDRE, Pascale; 38 me de la Loubiere, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 13006 Marseille (FR). BLERY, Mathieu; 50 Bd du Vais- DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, seau, Les Hauts de Mazargues Bt D4, 13009 Marseille (FR). DENIS, Caroline; 10 Rue Andre Audoli, 13010 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, Marseille (FR). PATUREL, Carine; 411 allee du bois, 69280 Marcy l'Etoile (FR). WAGTMANN, Nicolai; 16 GW, KM, ML, MR, NE, SN, TD, TG). Avenue Joseph Liautaud, 13260 Cassis (FR). Published: (74) Agent: VOLLMY, Lukas; Innate Pharma, 117 Avenue de — with international search report (Art. 21(3)) Luminy, 13009 Marseille (FR). — with sequence listing part of description (Rule 5.2(a)) = (54) Title: NEUTRALIZATION 5000- 40\" 3000- 1000 0 2000 ...._._.........F.,'.. OF INHIBITORY PATHWAYS IN LYMPHOCYTES Figure 8 IC 5000 PR: 0 % CR: 18 % 4000 3000 2000 • 1000 Anti-NKG2A C PR R :: ° 36 °A % 5000- 11 4000 3000 ei 2000 M kin 1000 kin 0 10 20 30 40 Anti-PD-L1 5000 PR: 0 % CR : 54 % 4000 3000 — 2000 1000 0 10 20 30 40 Anti-NKG2A + Anti-PD-L1 PR: 0 % CR: 82 % 1-1 0 10 20 30 40 0 10 20 30 40 It '' 11 (57) : This invention relates to the use of NKG2A-neutralizing agents to treat cancers that are poorly responsive to PD-1 N neutralizing agents, as well as to the combined use of NKG2A-neutralizaing agents and PD-1 neutralizing agents for the treatment of cancer. 0