baber/WOPTO huggingface dataset:
Patent JP-2980677-B2 (JP)
IPC: A61P25/28
Filed: 1991-03-26
Granted: 1999-11-22
Abstract: A method and composition are provided for alleviation of disease states associated with the abnormal accumulation and/or molecular organization of amyloid beta protein, such as manifested in Alzheimer's disease and other CNS amyloid disorders. The invention comprises the administration of a low level of amyloid beta protein, or a derivative thereof, which slows or reverses neuronal loss or function.
Patent JP-4156666-B2 (JP)
IPC: C12N15/10
Filed: 1996-08-12
Granted: 2008-09-24
Abstract: The present invention relates to a method for preparing positive polypeptide variants by shuffling different nucleotide sequences of homologous DNA sequences by in vivo recombination comprising the steps of   a) forming at least one circular plasmid comprising a DNA sequence encoding a polypeptide, b) opening said circular plasmid(s) within the DNA sequence(s) encoding the polypeptide(s), c) preparing at least one DNA fragment comprising a DNA sequence homologous to at least a part of the polypeptide coding region on at least one of the circular plasmid(s), d) introducing at least one of said opened plasmid(s), together with at least one of said homologous DNA fragment(s) covering full-length DNA sequences encoding said polypeptide(s) or parts thereof, into a recombination host cell,   e) cultivating said recombination host cell, and f) screening for positive polypeptide variants, wherein more than one cycle of step a) to f) are performed and/or wherein the shuffling is carried out with 2 or more DNA fragments with partially overlapping regions.   <IMAGE>
Patent JP-2992046-B2 (JP)
IPC: A61L15/62
Filed: 1989-09-27
Granted: 1999-12-20
Abstract: A biodegradable thermosetting polymer system is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. The thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. The system provides a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body. <IMAGE>   <IMAGE>
Patent JP-3607292-B2 (JP)
IPC: A61B5/022
Filed: 1994-12-15
Granted: 2005-01-05
Abstract: A method is disclosed for diagnosing, monitoring and treating cardiovascular pathologies. Among the hemodynamic parameters of interest are peripheral resistance, compliance, and cardiac (left ventricular) output. Peripheral resistance determined according to the present invention has been found to be a reliable indicator, not only of hypertension, but also of the cause of the hypertension. The determined peripheral resistance can be compared against a predetermined threshold value. This comparison helps to foster a diagnosis of a hypertensive condition.
Patent JP-3623962-B2 (JP)
IPC: A61K9/00
Filed: 1994-05-13
Granted: 2005-02-23
Abstract: PCT No. PCT/EP94/01567 Sec. 371 Date Jun. 17, 1996 Sec. 102(e) Date Jun. 17, 1996 PCT Filed May 13, 1994 PCT Pub. No. WO95/17164 PCT Pub. Date Jun. 29, 1995The invention relates to a pharmaceutical formulation, in a composition and form suitable for nasal administration, containing hydroxocobalamin dissolved in a concentration about 1% (w/w), having a viscosity of less than 1000 cP.
Patent JP-4492826-B2 (JP)
IPC: A61K35/761
Filed: 1997-11-20
Granted: 2010-06-30
Abstract: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.
Patent JP-4202417-B2 (JP)
IPC: A61K47/48
Filed: 1996-03-15
Granted: 2008-12-24
Abstract: This invention provides chimeric molecules useful for killing tumor cells bearing IL13 receptor(s) (IL-13R). The molecules comprise a cytotoxic molecule attached to a targeting molecule that specifically binds an IL-13 receptor. Preferred targeting molecules include IL-13 and anti-IL-13R antibodies.
Patent JP-2894841-B2 (JP)
IPC: G01N33/543
Filed: 1995-04-28
Granted: 1999-05-24
Abstract: Compositions, devices and methods for the detection of target microorganisms, such as by a visual immunoprecipitation assay, where the detection requires the migration of the target microorganisms (typically a target microorganism-antibody-detection reagent complex) along a lateral flow membrane of a diagnostic device. The present invention permits such detection by inhibiting the agglutination, or other aggregation, of target microorganisms (and particularly target microorganisms bound to an antibody-detection reagent) while the microorganisms are migrating along the lateral flow membrane.
Patent JP-3282824-B2 (JP)
IPC: C08F10/00
Filed: 1997-04-23
Granted: 2002-05-20
Abstract: Compounds of the formula:   <IMAGE>   wherein n is 1, 2, 3, or 4; X1 and X2 are each, independently, chlorine or bromine; A is O or S; R1 is hydrogen or C1-C16 alkyl; R2 is C1-C16 alkyl, C6-C16 aryl, C1-C4 alkylidene, or CH2OR5; R3 is hydrogen, chlorine, bromine, or OR6; R4 is C1-C16 alkyl, C7-C16 aralkyl, C2-C16 alkenyl, or C6-C18 aryl; R5 is hydrogen, C1-C16 alkyl, C7-C16 aralkyl, C2-C16 alkenyl, or C6-C18 aryl; and R6 is hydrogen or C1-C16 alkyl. These compounds by themselves and in combination with certain halo-but-2-enoic acids and esters are useful as catalyst promoters in ethylene polymerization processes.
Patent ES-2258912-B2 (ES)
Title: Metodo de refuerzo de piezas de piedra natural y material obtenido.
Inventor: GOMEZ CANTO JOSE ANTONIO
IPC: B32B7/12
Filed: 2004-12-22
Granted: 2008-03-16
Abstract: Método de refuerzo de piezas de piedra natural y material obtenido. Método empleado para que estas piezas presenten una mayor resistencia y evitar así su rotura durante la manipulación y transporte de las mismas, consistente en la adhesión a una losa o plancha de piedra natural (1) de otra placa cerámica (2), formando un cuerpo monopieza con la colaboración de adhesivos, de manera que sobre la superficie de la pieza de piedra (1) se aplica una capa de adhesivo y se coloca la fibra (3), cubriéndola a continuación con una o varias placas cerámicas (2), asegurando el contacto íntimo entre la piedra (1), el adhesivo, la fibra (3) y el material cerámico (2), por ejemplo ejerciendo presión sobre el conjunto. Opcionalmente se puede adherir a la otra cara de dicha pieza (1) otra capa de fibra (3'') y otra placa cerámica (2''), procediendo después al desdoble de la placa obtenida para conseguir dos piezas con una de sus caras reforzada.
Patent ES-2259554-B2 (ES)
Title: Capsula biocompatible para el control de animales u objetos.
Inventor: BENELMEKKI ERRETBY MARIA
IPC: A01K11/00
Filed: 2005-03-21
Granted: 2007-05-16
Abstract: Cápsula biocompatible para el control de animales u objetos, formada por una unidad electrónica (1) y una carcasa (2) de alojamiento, estando constituida la carcasa (2) por una estructura biocompatible, la cual se establece cerrada en sellado estanco mediante silicona o material similar, con fijación de la unidad electrónica (1) en el interior por el mismo material.
Patent ES-2310432-B2 (ES)
Title: Aparato de conversion para generador doblemente alimentado.
Inventor: ICHINOSE MASAYA
IPC: F03D7/04
Filed: 2006-01-04
Granted: 2010-07-05
Abstract: Aparato de conversión para generador doblemente
alimentado. 
     Un convertidor para excitación está protegido de
una co-  rriente  excesiva en un generador doblemente
alimentado, y se garantiza que  proporciona un funcionamiento
continuo. En el aparato de conversión para  el generador doblemente
alimentado, un convertidor para excitación tiene  un lado de
corriente continua conectado al de un convertidor para  asociación,
y un lado de corriente alterna conectado a un arrollamiento 
secundario de un generador doblemente alimentado, a través de una
primera  impedancia. Un rectificador de diodos tiene un lado de
corriente continua  conectado en paralelo con los lados de corriente
continua conectados del  primer convertidor y del segundo
convertidor, así como un lado de corriente  alterna conectado al
arrollamiento secundario del generador doblemente  alimentado, a
través de una segunda impedancia.
Patent ES-2303444-B2 (ES)
Title: (2,3-dihidro-5h-1,4-benzodiheteroepin-3-il)purinas con actividad antitumoral.
Inventor: CAMPOS ROSA JOAQUIN
IPC: C07D313/08
Filed: 2006-05-24
Granted: 2009-04-16
Abstract: (2,3-dihidro-5 H -1,4-benzodiheteroepin-3-il)purinas
con actividad antitumoral que encuentran aplicación en el
tratamiento  de tumores en animales y seres humanos, así como un
método para la preparación de los compuestos de la invención.
Patent AU-2001233873-B2 (AU)
Title: Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
Inventor: GARCIA-GRAVALOS DOLORES
IPC: A61K31/341
Filed: 2001-02-16
Granted: 2006-03-02
Abstract: Compounds of formula (I) wherein R1is selected from H, C(=O)R', P(=O)R'R'', S(=O)R'R'', substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or R1 together with R2 forms a saturated or unsaturated heterocyclic ring; R2 and R3 are each, independently, selected from H, C(=O)R', P(=O)R'R'', S(=O)R'R'', substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or one of R2 or R3 together with R1 forms a saturated or unsaturated heterocyclic ring; or R2 and R3 together form a saturated or unsaturated heterocyclic ring; R4 is selected from H, C(=O)R', P(=O)R'R'', S(=O)R'R'', substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18, alkynyl, or substituted or unsubstituted aryl, wherein R' is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, C(=O)H, C(=O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted and unsubstituted aryl; R'' is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, =O, C(=O)H, C(=O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18
Patent AU-2001236226-B2 (AU)
Title: Intervention device for a subsea well, and method and cable for use with the device
Inventor: CARLSEN HANS-PAUL
IPC: E21B33/076
Filed: 2001-02-20
Granted: 2006-05-18
Abstract: A well intervention tool suspension cable (9) comprises a plastics material (20) reinforced by carbon or glass fibres. The cable is relatively rigid, and comprises a low-friction coating (21). The cable may be used for suspending a tool (8) within a subsea well in an intervention operation. The cable (9) is fed from or withdrawn to a vessel (1) and driven by a drive mechanism (12) located on the vessel. The intervention equipment comprises a lubricator (5) having a tool housing for the insertion of the tool into the well, and a stuffing box (40) sealing around the cable after the tool is inserted into the well. An injector which drives the cable in the well is located on the lubricator, and is controllable independently of the drive mechanism for the cable located on the vessel. The drive mechanism and the injector may be synchronized in a manner, among others, providing that the cable hangs in a predetermined S-shaped curve during the intervention, whereby the vessel may be moved to one side of the well.
Patent AU-2001266014-B2 (AU)
Title: Stator support
Inventor: WOBBEN ALOYS
IPC: H02K1/18
Filed: 2001-05-23
Granted: 2005-02-17
Abstract: The present invention relates to a wind turbine having a generator with stator and rotor in a machine housing that is disposed at the top of the wind turbine tower, wherein the stator has a support construction comprising a plurality of support arms. The generator of the wind turbine is a ring generator.
Patent AU-2002248542-B2 (AU)
Title: Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
Inventor: LEE FRANCIS Y F
IPC: A61K33/24
Filed: 2002-03-05
Granted: 2007-01-18
Abstract: Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.
Patent AU-2002250362-B2 (AU)
Title: Lightweight armor with repeat hit and high energy absorption capabilities
Inventor: REICHMAN STEVEN H
IPC: F41H5/04
Filed: 2002-03-15
Granted: 2007-01-04
Abstract: A lightweight armor with repeat hit capability includes at least one layer of material that absorbs energy upon being impacted by an object through a reversible phase change and/or an elastic strain deformation of at least 5%. Once the energy of the object has been absorbed the layer of material returns to its original shape, thereby resulting in an armor with repeat hit capabilities. The armor may also include additional layers of material constructed of conventional armor materials. A method of manufacturing such an armor is also disclosed.
Patent AU-2002346018-B2 (AU)
Title: Multiple track incubator for clinical analyzer
Inventor: PORTE JOHANNES J
IPC: G01N35/02
Filed: 2002-06-28
Granted: 2008-06-12
Abstract: An incubator includes an incubator ring assembly having at least two concentric rings supported for rotation about a common axle defining an axis of rotation. Each concentric ring includes a plurality of circumferentially defined load positions, each load position being sized for accommodating a test sample. At least one test station is arranged in relation to the plurality of load positions to selectively test a test sample, the test samples being are sequentially shuttled into and out of load positions of at least one of the concentric rings to increase the overall throughput of the analyzer.
Patent AU-2003210565-B2 (AU)
Title: Nanofiber filter media
Inventor: KOSLOW EVAN E
IPC: D21H13/40
Filed: 2003-01-18
Granted: 2008-03-13
Abstract: The present invention is directed to an air filter medium comprising nanofibers, the filter medium having a thickness of less than 0.25 millimeters, a Figure of Merit of greater than about 0.075, and an efficiency of greater than about 99.9% when capturing aerosol particles of about 0.18 microns in size and a pressure drop of less than about 40 millimeters water column at a flow rate of about 32 liters/minute through a sample 100 cm<2 >in size. A coating of the nanofibers may also be used to enhance performance of existing filter media by increasing the FOM of the existing filter media. Preferably, the nanofibers are fibrillated.
Patent AU-2003226116-B2 (AU)
Title: Detection of DNA-binding proteins
Inventor: LAZAR JAMES G
IPC: C12Q1/44
Filed: 2003-03-28
Granted: 2010-04-01
Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
Patent AU-2003238849-B2 (AU)
Title: Polymerization catalyst activators, method of preparing and their use in polymerization processes
Inventor: CANO DAVID A
IPC: C08F4/659
Filed: 2003-05-29
Granted: 2007-02-15
Abstract: New polymerization catalyst activators are disclosed which include a heterocyclic compound, which may or may not be substituted, and an aluminum alkyl or an aluminoxane. Supported activators of the invention include the heterocyclic compound, combined with an alkylaluminum or aluminoxane, and a support material, preferably a silica support material. Also disclosed are methods for preparing these catalyst activators and polymerization processes utilizing same.
Patent AU-2003243228-B2 (AU)
Title: EphA2 monoclonal antibodies and methods of use thereof
Inventor: CARLES-KINCH KELLY
IPC: A61K39/395
Filed: 2003-05-12
Granted: 2009-03-26
Abstract: The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of an antibody that binds to EphA2 and agonizes EphA2, thereby increasing EphA2 phosphorylation and decreasing EphA2 levels. In other embodiments, the methods of the invention comprise the administration of an effective amount of an antibody that binds to EphA2 and inhibits cancer cell colony formation in soft agar, inhibits tubular network formation in three-dimensional basement membrane or extracellular matrix preparation, preferentially binds to an EphA2 epitope that is exposed on cancer cells but not non-cancer cells, and/or has a low Koff, thereby, inhibiting tumor cell growth and/or metastasis. The invention also provides pharmaceutical compositions comprising one or more EphA2 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.
Patent AU-2003254650-B2 (AU)
Title: Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
Inventor: CHEN JIANXIN
IPC: C07D521/00
Filed: 2003-07-23
Granted: 2010-09-09
Abstract: Topical formulations and method of using the same are provided. The topical formulation comprises a pyrazolylbenzothiazole derivative of the following formula (1) wherein X, R1, R2, R3 and R4 are described herein.
Patent AU-2003279393-B2 (AU)
Title: Method and device for hot-dip coating a metal strand
Inventor: BRISBERGER ROLF
IPC: C23C2/24
Filed: 2003-11-15
Granted: 2009-01-08
Abstract: A method for hot dip coating a metal strand includes passing the metal strand vertically through a coating tank that contains molten coating metal and through a guide channel upstream of the coating tank. A electromagnetic field is generated by inductors on both sides of the metal strand and an electromagnetic field superposed on the electromagnetic field of the inductors is generated by supplementary coils on both sides of the metal strand. A center position of the metal strand in the guide channel is stabilized by: (a) measuring the position of the metal strand in the guide channel; (b) measuring the induced current in the inductors; (c) measuring the induced current in the supplementary coils; and (d) influencing the induced current in the supplementary coils as a function of all of the parameters measured in steps (a) to (c).
Patent AU-2003288700-B2 (AU)
Title: Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
Inventor: LEVY ANDREW P
IPC: A61B/
Filed: 2003-12-31
Granted: 2009-11-19
Abstract: A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby a patient having a haptoglobin 2-2 phenotype benefits from anti oxidant therapy more than a patient having a haptoglobin 1-2 phenotype or a patient having a haptoglobin 1-1 phenotype.
Patent AU-2003291212-B2 (AU)
Title: Mine support
Inventor: VISAGIE JOSEPH CORNELIUS
IPC: E21D15/48
Filed: 2003-11-06
Granted: 2009-01-22
Abstract: A mine support having a ductile metal sleeve, an interior of which is filled with a first aerated cementitious material of a first density which extends over at least 60% of the axial length of the sleeve. The interior of the sleeve is also filled with a second aerated cementitious material of a second density, which is less than the first density, and which fills the remainder of the interior of the sleeve.
Patent AU-2003296366-B2 (AU)
Title: Synergistic compositions
Inventor: OWEN WILLIAM JOHN
IPC: A01N47/22
Filed: 2003-12-05
Granted: 2010-01-21
Abstract: Synergistic compositions useful as fungicides, comprising aminosulfones and at least one other fungicide are provided.
Patent AU-2003297567-B2 (AU)
Title: Method for determining whether at least one toll-required section of road is being traveled upon
Inventor: HARTINGER HORST
IPC: G07B15/06
Filed: 2003-09-09
Granted: 2009-07-30
Abstract: A method of, and a toll-collecting system (SYS) for, determining whether at least one toll road section is being used by a vehicle (FAR), wherein the position of the vehicle (FAR) is determined by means of at least one position calculating system (POS) and the determined position is implemented to ascertain whether the road section being used is a toll road section, and wherein the vehicle (FAR) has, in addition to said position calculating system, a transmitter/receiver unit (SEE) that is adapted to exchange data (DAT) with a cellular radio network (FUN), and that to each cell (ZEL) of the radio network (FUN) at least one cell identifier (ZID) is assigned, and when there is at least partial failure of the position calculating system (POS) the at least one cell ID (ZID) is implemented to ascertain whether the road section being used by said vehicle (FAR) is a toll road section.
Patent AU-2004215154-B2 (AU)
Title: Measurement of residual and thermally-induced stress in a rail
Inventor: DALZELL WILLIAM
IPC: G01L5/00
Filed: 2004-02-13
Granted: 2008-10-30
Abstract: In a railway line, thermally-induced stresses are a factor for both rail breaks and rail buckling. These stresses are in the longitudinal direction. A nondestructive measuring technique enables the residual stress in a rail to be determined, and hence the thermally-induced stress. An electromagnetic probe is used to measure the stresses in the rail web in the vertical direction, and in the direction parallel to the longitudinal axis. The residual stress in the longitudinal direction can be deduced from the measured stress in the vertical direction; hence the thermally-induced stress can be determined.
Patent AU-2004217283-B2 (AU)
Title: Method and apparatus for providing uplink signal-to-noise ratio (SNR) estimation in a wireless communication system
Inventor: MALLADI DURGA PRASAD
IPC: H04B7/26
Filed: 2004-03-08
Granted: 2008-07-17
Abstract: A method and apparatus for providing uplink signal-to-noise ratio (SNR) estimation in a wireless communication system. A first signal is received over a first channel and a second signal is received over a second channel, where the second signal is received at a higher signal power level than said first signal. A signal-to-noise ratio (SNR) of the second signal is measured, and the SNR of the first signal is determined based at least in part upon the measured SNR of the second signal.