Patent SG-11201903674Y-A (SG)
Title: Messenger ribonucleic acids for enhancing immune responses and methods of use thereof
Inventor: HUANG ERIC
IPC: A61K31/7088
Filed: 2017-10-26
Abstract: 12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau International Publication 03 May 2018 (03.05.2018) Publication Number 2018/081459 A9 111111101111011111111111H11101111111100111111111111111111111111111111111110111111111111 CORRECTED VERSION --, (10) International l i Date ...../ WO WIP0 I PCT (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) Applicant: MODERNATX, INC. [US/US]; (72) (74) (81) Designated States International Patent Classification: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A61K 31/7088 (2006.01) A61K 39/39 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). PCT/US2017/058585 Published: — with international search report (Art. 21(3)) 26 October 2017 (26.10.2017) (48) Date of publication of this corrected version: English 22 November 2018 (22.11.2018) English (15) Information about Correction: Priority Data: see Notice of 22 November 2018 (22.11.2018) 62/412,933 26 October 2016 (26.10.2016) US 62/467,034 03 March 2017 (03.03.2017) US 62/490,522 26 April 2017 (26.04.2017) US 62/558,206 13 September 2017 (13.09.2017) US 200 Technol- ogy Square, Cambridge, MA 02139 (US). Inventors: HUANG, Eric, Yi-Chun; 90 Wareham Street, Unit 302, Boston, MA 02118 (US). TSE, Sze-Wah; 200 Technology Square, Cambridge, MA 02139 (US). IACOV- ELLE Jared; 20 Rich Street #2, Waltham, MA 02451 (US). MCKINNEY, Kristine; 73 Highland Ave, Cambridge, MA 02139 (US). HOPSON, Kristen; 331 Appleton Street, Ar- lington, MA 02476 (US). Agent: MANDRAGOURAS, Amy, E. et al.; Nelson Mullins Riley & Scarborough LLP, One Post Office Square, Boston, MA 02109-2127 (US). (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (84) 0\ in 71' 1-1 (54) Title: 00 MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METHODS OF USE THERE- OF E .-- 4 (57) : The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of 4 7 1 interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or (1 more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when eft s administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.