Patent SG-11201907884X-A (SG)
Title: Method of identifying malodor modulating compounds
Inventor: PFISTER PATRICK
IPC: G01N33/50
Filed: 2018-03-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT oimitia °noI0 OilIIIIIOil1011o Oilno iflo oimIE (10) International Publication Number WO 2018/162638 Al (51) International Patent Classification: C07K 14/705 (2006.01) G01N 33/53 (2006.01) G01N 33/50 (2006.01) (21) International Application Number: PCT/EP2018/055753 (22) International Filing Date: 08 March 2018 (08.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469256 09 March 2017 (09.03.2017) US (71) Applicant: FIRMENICH SA [CH/CH]; 1, route des Je- unes P.O. Box 239, 1211 GENEVA 8 (CH). (72) Inventors: PFISTER, Patrick; Firmenich Incorporated 250 Plainsboro Road, Plainsboro, New Jersey 08536 (US). ROGERS, Matthew; Firmenich Incorporated 250 Plains- boro Road, Plainsboro, New Jersey 08536 (US). KAO, Huey-Ling; Firmenich Incorporated 250 Plainsboro Road, Plainsboro, New Jersey 08536 (US). ABIBI, Claude, Ay- ome; Firmenich Incorporated 250 Plainsboro Road, Plains- boro, New Jersey 08536 (US). (74) Agent: BAUMGARTNER HARRIS, Pauline; 1, route des Jeunes P.O. Box 239, 1211 GENEVA 8 (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) - before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (54) Title: METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS (57) : Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.