Patent ES-2579980-T3 (ES)
Title: Derivados de tetrahidro-quinazolinona como inhibidores de TANK y PARP
Inventor: BUCHSTALLER HANS-PETER
IPC: C07D403/12
Filed: 2013-01-14
Granted: 2016-08-18
Abstract: Compuestos seleccionados del grupo N.º Nombre y/o estructura "A5" 2-[4-(3-fluorofenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A6" 2-[4-(4-fluorofenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A8" 2-[4-(4-clorofenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A9" 2-[4-(2-clorofenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A10" 2-(4-trifluorometilpiperidin-1-il)-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A11" 2-[4-(3-clorofenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A13" 2-(4-terc-butilpiperazin-1-il)-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A14" 2-[4-(4-metoxifenil)-3-oxopiperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A15" 2-[4-(piperidin-1-carbonil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A16" 2-[4-(6-hidroxipiridin-2-il)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A18" N-piridin-2-il-2-[4-(4-oxo-3,4,5,6,7,8-hexahidroquinazolin-2-il)piperazin-1-il]acetamida "A19" 2-(4-acetilpiperazin-1-il)-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A20" 2-[4-(morfolin-4-carbonil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A21" 2-[4-(3-aminopropanoil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A22" 2-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]piridin-3-carboxamida "A23" 2-[4-(4-oxo-3,4,5,6,7,8-hexahidroquinazolin-2-il)piperazin-1-il]-N-piridin-3-ilacetamida "A24" 2-[4-(2,2-dimetilpropanoil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A25" 2-[4-(2-hidroxietil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A26" 2-[4-[2-(2-piridil)etil]piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A27" 2-[4-(piperidin-2-carbonil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A28" 4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-2-carboxamida "A29" 2-[3-(hidroximetil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A30" (2R)-1-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-2-carboxamida "A31" 2-[(2R)-2-(hidroximetil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A32" 2-[4-(3-piridil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona~ "A33" 2-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]benzonitrilo "A34" 2-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]benzamida "A35" 2-(4-hidroxi-4-fenil-1-piperidil)-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A36" 2-[4-(4-fluoro-2-metoxi-fenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A37" 2-[4-(2,4-dimetoxifenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A38" 2-[4-(2-cloro-4-metoxi-fenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A39" 2-[4-(2-cloro-4-fluoro-fenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A40" 2-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]acetamida "A41" 2-(3-fenilpiperazin-1-il)-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A42" 2-[4-(2-isopropoxifenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A43" 2-[4-[2-(trifluorometoxi)fenil]piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A44" 2-[4-(6-metoxipiridazin-3-il)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A45" 4-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]benzonitrilo "A46" 2-[4-[4-(4-oxo-5,6,7,8-tetrahidro-3H-quinazolin-2-il)piperazin-1-il]fenil]acetonitrilo "A47" 2-[4-[4-(trifluorometoxi)fenil]piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A48" 2-[4-(4-etoxifenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A49" 2-[4-(4-isopropoxifenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A50" 2-[4-(4-trifluorometilfenil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A51" 2-[4-(6-metoxi-3-piridil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A52" 2-[4-(5-metoxi-2-piridil)piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A53" 2-[4-hidroxi-4-(4-metoxi-fenil)-piperidin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A54" 2-[4-(2-metoxi-fenil)-piperidin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A55" 2-[4-(4-metoxi-fenil)-piperidin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A56" 2-[4-(2-trifluorometil-fenil)-piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona "A57" 2-[4-[2-(1-hidroxi-1-metiletil)fenil]piperazin-1-il]-5,6,7,8-tetrahidro-3H-quinazolin-4-ona y solvatos, sales, tautómeros y estereoisómeros farmacéuticamente aceptables de los mismos, incluyendo mezclas de los mismos en todas las razones.