baber/WOPTO huggingface dataset:
Patent CA-2317589-A1 (CA)
Inventor: SMITH KATHRYN JANE
IPC: C07D239/94
Filed: 1999-01-08
Abstract: Substituted heteroaromatic compounds of formula (I), wherein X is N or CH; Y  is CR1 and V is N; or Y is N and V is CR1; or Y is CR1 and V is CR2; or Y is CR2 and V is CR1; R1 represents a group CH3SO2CH2CH2NHCH2-Ar-, wherein Ar is selected from phenyl, furan, thiophene, pyrrole and thiazole, each of which may optionally be substituted by one or two halo, C1-4alkyl or C1-4alkoxy groups; R2 is selected from the group comprising hydrogen, halo, hydroxy, C1-4alkyl, C1-4alkoxy, C1-4alkylamino and di[C1-4alkyl]amino;  U represents a phenyl, pyridyl, 3H-imidazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, 1H-indazolyl, 2,3-dihydro-1H-indazolyl, 1H-benzimidazolyl, 2,3-dihydro-1H-benzimidazolyl or 1H-benzotriazolyl group, substituted by an R3 group and optionally substituted by at least one independently selected R4 group; R3 is selected from a group comprising benzyl, halo-, dihalo- and trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- and trihalobenzyloxy and benzenesulphonyl, or R3 represents trihalomethylbenzyl or trihalomethylbenzyloxy; or R3 represents a group of formula (a) wherein each R5 is independently selected from halogen, C1-4alkyl, C1-4alkoxy; and n is 0 to 3; each R4 is independently hydroxy, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, amino, C1-4alkylamino, di[C1-4alkyl]amino, C1-4alkylthio, C1-4akylsulphinyl, C1-4alkylsulphonyl, C1-4alkylcarbonyl, carboxy, carbamoyl, C1-4alkoxycarbonyl, C1-4alkanoylamino, N-(C1-4alkyl)carbamoyl, N,N-di(C1-4alkyl)carbamoyl, cyano, nitro and trifluoromethyl; and salts and solvates thereof, are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.
Patent CA-2321175-A1 (CA)
Inventor: DENNLER SYLVIANE GABRIELLE NAD
IPC: C12Q1/68
Filed: 1999-02-04
Abstract: Procédé de criblage d'agents thérapeutiques destinés à être utilisés pour lutter contre des maladies associées à la régulation génique par une ou plusieurs protéines Smad et par TGF.beta. ou par l'activine. Ledit procédé consiste à détecter ou à analyser l'ampleur ou le résultat de l'activité de transcription ou la liaison, en présence dudit agent, d'une protéine Smad ou d'un fragment de liaison d'ADN de ladite protéine et d'un oligonucléotide double brin comprenant la séquence 5' WXYCAGACZ 3' ou un équivalent fonctionnel de ladite séquence, dans laquelle W représente A ou G, X représente G ou T, Y représente C, A, G ou T et Z représente A ou C. La présente invention concerne également des agents thérapeutiques identifiés par ledit procédé et leur utilisation pour lutter contre des maladies associées à l'expression anormale de gènes à médiation Smad et induits par TGF.beta..
Patent CA-2326066-A1 (CA)
Inventor: FORD JOHN
IPC: C07K16/24
Filed: 1999-04-05
Abstract: The present invention provides nucleic acids, the polypeptide sequences encoded by these nucleic acids and uses thereof. These polynucleotide and polypeptide sequences were determined to be a Interleukin-1 Receptor Antagonist.
Patent CA-2326519-A1 (CA)
Title: Boucle a phase asservie
Inventor: NAKAJIMA MASAMICHI
IPC: H03L7/089
Filed: 1999-03-31
Abstract: L'invention concerne une boucle à phase asservie comportant un comparateur (20) de phase, un filtre (21) de boucle, un oscillateur (14) commandé en tension (VCO) et un compteur (22) de boucle. La boucle à phase asservie comporte en outre un circuit de fenêtre (23) de prédiction qui produit un signal de fenêtre de prédiction HWIN servant à prévoir des positions dans lesquelles apparaissent des signaux REF (signal étalon), et un circuit (24) de compensation de perte qui détecte une perte du signal de sortie REF ou HWIN, et produit un signal d.REFX (premier signal correcteur) servant à compenser la perte ainsi qu'un signal d.VARX (deuxième signal correcteur) servant à compenser une différence de phase entre VAR (signal de comparaison) et d.REFX. Si REF est perdu, le comparateur (20) de phase effectue une compensation appropriée. Si la différence de phase entre REF et VAR avoisine 0, une tension de commande précise dépendant de la différence de phase est fournie au VCO par un signal (Gc) de commande de porte qui est en avance d'une impulsion de synchronisation par rapport à la phase VAR.
Patent CA-2327835-A1 (CA)
Inventor: MACDONALD GENE H
IPC: A61K39/193
Filed: 1999-04-08
Abstract: La présente invention concerne des méthodes de prévention et/ou de traitement du cancer (y compris des tumeurs). Selon une version privilégiée de l'envention, celle-ci permet de faire régresser un cancer ou des tumeurs existant(es) et/ou d'empêcher l'apparition de métastases ou bien encore d'inhiber la croissance de nodules métastatiques. Dans d'autres versions privilégiées, l'invention peut être utilisée à titre prophylactique pour prévenir l'apparition de cancers primaires par un programme de vaccination des enfants ou des adultes contre des antigènes tumoraux spécifiques de cancers à forte incidence. Dans une autre version privilégiée, la présente invention décrit des méthodes permettant de déclencher, grâce à un programme de vaccination de l'enfant ou de l'adulte, une réponse immunitaire contre un antigène tumoral artificiel universel et, ainsi de garantir une réponse immunitaire durable pouvant être exploitée à tout moment pour le traitement de tout cancer apparu ultérieurement. La présente invention concerne également des cellules cancéreuses ou tumorales qui expriment de façon stable un antigène artificiel, de préférence un antigène artificiel de surface.
Patent CA-2329432-A1 (CA)
Title: Pallet for clamping a workpiece to be processed
Inventor: AROSIO MASSIMO
IPC: B23Q3/08
Filed: 2000-12-21
Abstract: A pallet for clamping a workpiece to be processed, in particular by machining operations, wherein the pallet is connected to a holding fixture which accommodates a quick-acting connection which is provided with conduits for the feed of a hydraulic fluid to a piston/cylinder unit and with a quick-acting connection in combination with conduits for the return of the hydraulic fluid, in which case these first connections can be connected to second quick-acting connections which are connected to a conduit for the feed of the hydraulic fluid and to a conduit for the return of the hydraulic fluid to a hydraulic supply unit, and the second quick-acting connections are arranged in a holding body which has an actuating lever for a connecting device, and the actuating lever has an eccentric slot, which can be connected to a guide pin which is fastened to the holding body for the first quick-acting connections.
Patent CA-2332450-A1 (CA)
Title: Esterified and subsequently hydrogenated phytosterol compositions and use thereof in foods, beverages, pharmaceuticals, nutraceuticals and the like
Inventor: ZAWISTOWSKI JERZY
IPC: A23L3/349
Filed: 1999-05-14
Abstract: The present invention provides an esterified and subsequently hydrogenated phytosterol composition for use alone or for incorporation into foods, beverages, pharmaceuticals, nutraceuticals and the like. The composition has  the advantage of enhanced solubility and dispersability, increased molar potency and enhanced stability over other known compositions. Methods for th e esterification and subsequent hydrogenation are also provided.
Patent CA-2332866-A1 (CA)
Title: Network based electrical control system with distributed sensing and control
Inventor: HEBEISEN STEPHEN P
IPC: G01K1/04
Filed: 1999-05-13
Abstract: An electrical control system including a plurality of electrical devices having the ability to communicate over a network as well as the ability to interface and work with non-protocol devices and signals that only send/receive an on/off digital signal or send/receive one of numerous analog signals. The electrical devices include sensors (448, 450), transceiver (92), switching devices (544), dimming devices (400) and controlling (90). The devices communicate with one another over a network that may be implemented using one or more different types of media such as twisted pair, power line carrier, coaxial, optical fiber, RF, infrared, etc. The system is particularly suited for lighting control applications within an office, building, room or home. The electrical devices that comprise the control system generally comprise one or more of the following five basic elements: (1) user interface, (2) actuator element, (3) power supply (432) and media connections, (4) communications media and protocol and (5) one or more sensor inputs (448, 450).
Patent CA-2333387-A1 (CA)
Inventor: SANCHEZ GUISADO FERMIN
IPC: E02F9/28
Filed: 1999-06-03
Abstract: The device is characterized by the coupling protuberance of the tooth in a zone which is adjacent to the base of the tooth and is comprised of side faces which are both inclined from said base towards the axis of the piece and from the lower edge inwardly and also presenting an upper face inclined from top to bottom and a lower planar face, continued into a second zone which presents additionally planar faces extending from the lower edges of the protuberance and showing an inward inclination; the coupling protuberance is terminated by a posture section of which the side faces extend from an upper planar face which is parallel to the piece axis, and inclined inwardly and joining a unique lower face which is also planar and parallel to the piece axis and terminated at the planar extremity of the protuberance which is perpendicular to the piece axis.
Patent CA-2336822-A1 (CA)
Inventor: DE GASPARO MARC
IPC: A61P9/12
Filed: 1999-07-09
Abstract: The invention relates to a method for the treatment or prevention of a condition or disease selected from the group consisting of hypertension, (acute and chronic) congestive heart failure, left ventricular dysfunction a nd hypertrophic cardiomyopathy, myocardial infarction and its sequelae supraventricular and ventricular arrhythmias, atrial fibrillation or atrial flutter, atherosclerosis, angina (whether stable or unstable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, hypertension in patients with NIDDM, secondary aldosteronism, primary and secondary pulmonary hyperaldosteronism, primary and pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primar y renal disease, and also renal vascular hypertension, diabetic retinopathy, t he management of other vascular disorders, such as migraine, Raynaud's disease,  luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), and stroke , comprising administering a therapeutically effective amount of combination o f (i) the AT1-antagonists valsartan or a pharmaceutically acceptable salt thereof and (ii) a Calcium channel blocker or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier to a mammal in need o f such treatment and to corresponding pharmaceutical combination composition.< /SDOAB>
Patent CA-2338973-A1 (CA)
Inventor: LAGRANGE ALAIN
IPC: A61K8/00
Filed: 2001-02-23
Abstract: L'invention a pour objet une composition pour la teinture d'oxydation des fibres kératiniques contenant au moins un dérivé d'indolizine à titre de coupleur et au moins une base d'oxydation. L'invention a également pour objet l'utilisation de dérivés d'indolizine à titre de coupleur pour la teinture d'oxydation des fibres kératiniques en association avec au moins une base d'oxydation, ainsi que les procédés de teinture les mettant en oeuvre. L'invention permet d'obtenir de nouvelles teintures puissantes, peu sélectives et particulièrement résistantes, capables d'engendrer des colorations intenses dans des nuances variées, en utilisant des dérivés d'indolizine particuliers.
Patent CA-2340820-A1 (CA)
Title: Game utilizing non-identical sequential images as a winning condition
Inventor: PALUDI LOUIS B
IPC: A63F3/00
Filed: 2001-03-15
Abstract: A method of playing a game in which a library contains a plurality of events depicted in a series of sequential, non-identical images identified as a first image, a second image, etc. A first image selected from the plurality of first images in the library is displayed in a frame, such as a frame on a video monitor. Likewise, a selected one of the second images from the plurality of second images in the library is displayed in a second frame. If the images displayed in the frames sequentially depict the first and second images of the event, then a winning condition is achieved.      An apparatus for performing the method is also disclosed.
Patent CA-2341407-A1 (CA)
Title: Home zone service method for mobile telephone subscribers in mobile radio communication system
Inventor: LEE YUN-HEE
IPC: H04W4/24
Filed: 2000-07-03
Abstract: Disclosed is a home zone service method for assigning a specified zone to a mobile telephone subscriber and charging the subscriber at different billing  rated accordingly as the subscriber makes a telephone call inside or outside  the zone. According to the home zone service method, a zone which is defined  by a first measurement value and a second measurement value as a sub-sector is determined by measuring a round trip delay from a fixed location in a sector  of a cell to the neighbor base stations to which the subscriber belongs, so that a predetermined home zone database including the first value and the second value is prepared. The round trip delay is measured from a specified signal if a portable mobile terminal of the subscriber generates a request signal to establish a call connection. Then, it is determined whether the subscriber is located inside the sub-sector if the measured round trip delay  falls between the first value and the second value of the home zone database .
Patent CA-2342705-A1 (CA)
Inventor: LAFOND DANIELLE
IPC: A61J9/00
Filed: 2001-04-04
Abstract: A support used with a breast pump and with a flexible bag adapted to be filled with breast milk, comprises a hollow body having opposed upper inlet and lower outlet ends adapted to be fluidly connected respectively to an outlet of the breast pump and to an inlet of the flexible bag, such that milk retrieved by the breast pump from a breast is conveyed by the breast pump through the support and directly into the flexible bag. The lower end is typically inserted in a mouth of the flexible bag which is then attached temporarily, that is until the bag has been filled with milk, to the support by way of an attachment system, such as a tie provided on the flexible and positioned around the lower end of the support, or of an elastic member positioned around the flexible for inwardly urging the same against the lower end. The lower end may define a flared edge, positioned downstream of the attachment system of the flexible bag, when the bag is attached to the support, for assisting in preventing the flexible bag from accidentally coming off the support. The support may also include a handle that extends from the hollow body for helping a user in holding the support, as well as a stand that is adapted to hold the hollow body at a distance above a support surface on which the stand rests, such that the bag hangs from the hollow body and above a base of the stand. The lower end of the hollow body may define a peripheral groove for receiving the attachment system of the flexible bag thereby assisting in preventing the flexible bag from accidentally coming off the support.
Patent CA-2343061-A1 (CA)
Title: Contact lens comprising a violet tint
Inventor: OCAMPO GERARDO J
IPC: C08F2/44
Filed: 1999-09-07
Abstract: Adding a small quantity of a violet colorant to a contact lens material provides a clear contact lens that has no apparent undesirable yellow tint such as caused by a UV-absorbing compound. Further, the violet colorant can also be used with a colored lens, in the absence of the handling tint, to mask any undesirable yellow tint, such as that produced by a UV-absorbing compound. The violet colorant will not unacceptably alter the modifying color of the colored lens.
Patent CA-2344101-A1 (CA)
Title: Cryogenic air separation system using an integrated core
Inventor: ARMAN BAYRAM
IPC: F25J3/04
Filed: 2001-04-12
Abstract: A cryogenic air separation system wherein an integrated core receives and cools an incoming feed air stream, a rectification section facilitates mass transfer of the feed air stream, a separation section in a heat exchange relationship with the rectification section processes fluid from the rectification section, and a section in a heat exchange relationship with an entrance passage discharges fluid from the integrated core.
Patent CA-2348027-A1 (CA)
Inventor: HAMABE KOJIRO
IPC: H04B7/02
Filed: 1999-11-02
Abstract: A transmission power control method and device in a mobile communication system. The reception quality of signals (31, 32a, 32b, 41, or 42) transmitt ed from another mobile station (51 or 52) or a base station (21 or 22) is compared with a predetermined control desired value such as the ratio of signal to interference power, and the comparison result is used for controlling the transmission power to the other end. When a frame error is detected in the transmitted signals, the control desired value is increased by SIRinc. When no frame error is detected, the control desired value is decreased by SIRdec, and SIRdec is made the product of the desired value of the frame error rate and SIRinc. Thus, when the propagation environment or t he speed of a multi-path changes, the control desired value of the transmission  power control can be changed in a short time to maintain the line quality constant, thereby realizing a desired line quality.
Patent CA-2348358-A1 (CA)
Inventor: GERSHONY MOSHE
IPC: H04N1/405
Filed: 2001-05-24
Abstract: Method and apparatus for performing halftoning of an image, using two 2-dimensional look up tables (LUTS). The first LUT receives coordinates of an image value and outputs a screen reference value which then serves, together with the image value as address for the second LUT.      The output of the second LUT is the halftone value.
Patent CA-2349022-A1 (CA)
Title: Method and apparatus for trimming an internal combustion engine
Inventor: HAFNER GREGORY G
IPC: F02D41/38
Filed: 2001-05-29
Abstract: A fuel injection control system and method for trimming an internal combustion engine during a fuel injection event based upon engine operating conditions, the control system including an electronic controller in electrical communication with the engine, the controller being operable to detect the operating mode of each injector of the engine and alter each injector operating mode as desired.
Patent CA-2350453-A1 (CA)
Title: Method and apparatus for removing water from well-bore of gas wells to permit efficient production of gas
Inventor: LIKNES ALVIN C
IPC: E21B43/12
Filed: 2001-06-13
Abstract: Method and apparatus for removing water from a gas well to permit efficient production of gas while protecting formation from introduced pressures. The apparatus comprises a check valve that seals the casing from production zone when hydrostatic pressure of water from production accumulates in casing above production perforations and checkvalue exceeds formation pressure. When the casing is sealed, a compressor pressurizes gas into the casing but not an exhaust conduit, the top of the casing being sealed around the exhaust conduit, permitting communication between the conduit and a suitable destination, such as via liquid separators on into sale pipeline. Accumulated water is caused to flow into the bottom of the exhaust conduit and out at surface to collection. When pressure within the sealed casing to the top end of exhaust conduit is equalized, the checkvalve opens and regular production can resume.
Patent CA-2351146-A1 (CA)
Title: Chimiokine cxc h174 et techniques permettant de prevenir des lesions du systeme nerveux
Inventor: DORF MARTIN E
IPC: A61K38/00
Filed: 1999-11-16
Abstract: La présente invention concerne des polynucléotides comprenant des séquences codant la chimiokine CXC H174 ou ses formes modifiées, la chimiokine CXC H174 codée et ses formes modifiées, des procédés d'identification des inhibiteurs de l'interaction entre H174 et ses récepteurs, ainsi que des techniques de traitement de pathologies du système nerveux impliquant H174.
Patent CA-2351685-A1 (CA)
Inventor: BOESCH RONALD D
IPC: H04B1/04
Filed: 1999-10-20
Abstract: Cette invention se rapporte à un amplificateur RF, qui comprend un modulateur de phase développant un signal d'entrée RF modulé en phase, devant être transmis. A cet effet, un amplificateur de puissance reçoit le signal d'entrée RF et l'amplifie, afin de développer un signal de sortie RF. Une commande d'amplificateur est associée fonctionnellement au modulateur de phase et à l'amplificateur de puissance. Cette commande d'amplificateur comprend une mémoire servant à stocker des informations de correction mettant en corrélation l'amplitude souhaitée du signal de sortie RF et l'amplitude effective de l'amplificateur, et une commande fait varier la tension d'alimentation de l'amplificateur en réponse aux informations de correction, afin de linéariser la modulation d'amplitude dans l'amplificateur de puissance.
Patent CA-2351719-A1 (CA)
Title: Pharmaceutical compositions containing olanzapine-n-oxide
Inventor: YELLE WILLIAM E
IPC: A61P25/22
Filed: 1999-11-22
Abstract: Methods and compositions are disclosed utilizing olanzapine-N-oxide for the treatment of psychosis in humans. Olanzapine-N-oxide exhibits a lessened liability toward drug-drug interactions than olanzapine and a more predictab le dosing regimen than olanzapine. Olanzapine-N-oxide is also useful for the treatment of acute mania, mild anxiety states, anxiety disorders, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autistic disorder, excessive aggression, substance abuse, depressive signs a nd symptoms, tic disorder, functional bowel disorder and fungal dermatitis.</SD OAB>
Patent CA-2352917-A1 (CA)
Title: Method and apparatus for determining, in real-time, a statistical bandwidth used in an atm satellite communications network
Inventor: PRIETO JAMIE L JR
IPC: H04L12/70
Filed: 2001-07-11
Abstract: A method and apparatus are provided for determining, in real-time, a statistical bandwidth being used by at least one data stream of a communications satellite 10. An outbound module 100 within a satellite 10 includes at least one buffer 104-112 for queuing a data stream received in an uplink and transmitted in a downlink. The outbound module 100 includes a switch 102 for directing packets from multiple data streams to corresponding buffers 104-112 depending upon the quality of service associated with each data stream and corresponding buffer 104-112. A packet monitor 116 monitors the data stream traffic to each buffer 104-112 in order to measure traffic parameters such as the number of packets or bits received per second by one buffer 104-112 or multiple buffers in an outbound module 100. The traffic parameters may also include a count of the packets or bits received over a period of time by one or more buffers. A bandwidth measurement module 114 calculates the statistical bandwidth associated with each data stream based upon the traffic parameters measured by the packet monitor 116. The bandwidth measurement 114 module may further calculate the statistical bandwidth actually being used by the entire outbound module 100.