Patent SG-11201903306S-A (SG)
Title: Multimeric il-15-based molecules
Inventor: WONG HING
IPC: C07K14/715
Filed: 2017-10-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 0 11101 HOE 3E1 0 011101 Ell 1101111111011101111011011# Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/075989 Al 26 April 2018 (26.04.2018) WI P0 I PC T (51) International Patent Classification: 29th St, Miramar, FL 33025 (US). LIU, Bai; 9631 NW CO7K 14/54 (2006.01) CO7K 14/47 (2006.01) 39th Street, Cooper City, FL 33024 (US). XU, Wenxin; CO7K 14/705 (2006.01) CO7K 16/24 (2006.01) 11917 SW 12th Street, Pembroke Pines, FL 33025 (US). C07K 16/18 (2006.01) C07K 16/28 (2006.01) NEWMAN, Robby; 2810 North Commerce Parkway, Mi- C07K 14/715 (2006.01) C07K 16/30 (2006.01) ramar, FL 33025 (US). KAGE, Karen; 2810 North Com- C07K 14/435 (2006.01) C07K 16/32 (2006.01) merce Parkway, Miramar, FL 33025 (US). YOU, Lijing; (21) International Application Number: 2810 North Commerce Parkway, Miramar, FL 33025 (US). PCT/US2017/057757 RHODE, Peter; 14857 SW 42nd Lane, Miami, FL 33185 (US). SOON-SHIONG, Patrick; 9920 Jefferson Blvd, (22) International Filing Date: Culver City, CA 90232 (US). 21 October 2017 (21.10.2017) (74) Agent: CORLESS, Peter, F. et al.; Mintz Levin Cohn Fer- (25) Filing Language: English ris Glovsky and Popeo, P.C., One Financial Center, Boston, MA 02111 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/411,216 21 October 2016 (21.10.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/513,964 01 June 2017 (01.06.2017) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicants: ALTOR BIOSCIENCE CORPORATION DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, [US/US]; 2810 North Commerce Parkway, Miramar, FL HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, _ 33025 (US). NANTCELL, INC. [ /US]; 9920 Jefferson KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, — Boulevard, Culver City, CA 90232 (US). MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = — OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (72) Inventors: WONG, Hing, C.; 2966 Wentworth Street, = Weston, FL 33332 (US). MARCUS, Warren; 8382 SW = = (54) Title: MULTIMERIC IL-15-BASED MOLECULES = FIG. 1 PD-1 s.,,—mi 4, _ = — = Antigen -Specific _ = = . = = \ _ Binding Domains Against .-q 1 , ..), 411111111: PD -L1 s . 1* - 11071; • .. . i P Diseased Cell ,,., 1 S Antigen , , 1, / v 1 ki c \: I e IL-1 5N72D #0L Disease trlir-$ • \ , 1 I i. N..i k I ir 11,'\" APII\" s II r • I i -= ., ,,),;.'' $ — --ke ,,, e il kl4 v Activated T Cell - 4.. = ___ _ A = - -m IL-15Ra _.- PD-1 — m m = — Il M MIgG1 Fc NIQ T Cell / ‘ 1- Macrophage NK Cell / Macrophage 01 r 00 IL-15R07c C:7\ Receptors Low Affinity Fc/ Receptors 11 in IN CZ ---.... Il C:::: ) (57) : The invention features multi- specific protein complexes with one domain comprising IL-15 or a functional variant and ei a binding domain specific to a disease antigen, immune checkpoint or signaling molecule. [Continued on next page] WO 2018/075989 Al MIDEDIMOMOIDEIREIDIONOMIHRIONEVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))