baber/WOPTO huggingface dataset:
Patent JP-2001222364-A (JP)
Title: Information processor, its method and medium
Inventor: YAMAGUCHI SACHIHIRO
IPC: G06F3/0489
Filed: 2000-12-14
Abstract: PROBLEM TO BE SOLVED: To solve a problem that complicated operations are repeated until a user selects a desired application program and starts it on a task bar having a start menu key in the conventional operating system. SOLUTION: A CPU 51 monitors whether a jog dial 4 is operated. In addition, whether an electronic mail program 54A and other application 54F1 to 54Fn are activated is monitored. Monitoring of the state of the jog dial here is to monitor processing from a jog dial state monitoring program 70E on the side of the CPU 51 via a jog driver 54D. The CPU 51 judges whether any active application exists when the operating information of the jog dial 4 is given from the jog dial driver 54D and when no active application exists, the processing proceeds to a launcher operation and when the active application exists, the processing proceeds to an event operation.
Patent JP-2002146792-A (JP)
Title: Expansion handrail for preventing falls, for use in simplified earth retaining panel installing method in sewage works
Inventor: KADOMICHI MITSUHARU
IPC: E02D17/08
Filed: 2000-11-09
Abstract: PROBLEM TO BE SOLVED: To provide an expansion handrail for preventing falls, which can be set on an excavated earth retaining panel and mounted/dismounted in a short period of time. SOLUTION: Supports 1 having the handrail attached thereto are erectly inserted into two joint holes in a panel. The insertion work is repeatedly successively carried for each earth retaining panel. Since the handrail 3 is set on the earth retaining panel, work near an excavated area is safely carried out. Connection of the handrails 3 on the respective panels is implemented by the expandable handrails 3, whereby the handrails 3 are sequentially connected. Since the expandable handrails 3 are connected together, they are sequentially set according to displacement of the panels. By repeatedly carrying out the above procedures, the handrails 3 are successively set at locations where installation of the excavated earth retaining panels is completed, and therefore work can be safely carried out.  By virtue of the expansion handrails for preventing falls and the method of setting the same, in implementation of the simplified earth retaining panel installing method, the handrails can be successively set at the locations where installation of the earth retaining panels is completed, falling accidents can be prevented, to thereby achieve safe execution of sewage works.
Patent JP-2002184631-A (JP)
Title: Ignition coil device for internal combustion engine
Inventor: KAMATA TAKAHIRO
IPC: H01F38/12
Filed: 2000-12-18
Abstract: PROBLEM TO BE SOLVED: To provide an ignition plug device for internal combustion engine, which can surely produce a spark discharge, even if it used in arctic regions. SOLUTION: Iron cores (26 and 27) of a coil-core assembly 21 are placed parallel to a bottom 14A of an insulation case body 12A on the bottom 14A of the case 12A, in which the upper surface forming an insulation case 11A is open; and by making an insulation resin 31 charged inside the case 11A and solidified, forming an ignition coil device is formed for an internal combustion engine, in which respective members of the assembly 21 are insulated and fixed inside the case 11A; and a circular curved part 14a is formed around the outer circumferential edge of the bottom 14A of the case 11A.
Patent JP-2002189469-A (JP)
Title: Electronic musical instrument
Inventor: MIKI JUNICHI
IPC: G10G7/02
Filed: 2000-12-20
Abstract: PROBLEM TO BE SOLVED: To provide an electronic musical instrument which helps a performance or singing more carefully than before when recording the performance and the singing by using a metronome sound. SOLUTION: The performance or the singing is performed toward a microphone 10 in accordance with the metronome sound with a tempo and a pitch set by using an operation panel 40. Audio signals from the microphone 10 is amplified by a microphone amplifier 20, and wave data are stored into a memory 60 via an ADC(analog-to-digital converter) 30 and a CPU 70. The sound of a pitch based on a sound pitch in performance data from a keyboard 50 and a pitch set by the operation panel 40 is played back at a set performance tempo by the CPU 70 and a DAC(digital-to-analog converter) 80 to emit a sound from a loudspeaker 90.
Patent JP-2002186577-A (JP)
Title: Distal end part of lateral view type endoscope
Inventor: OUCHI NAOYA
IPC: G02B23/26
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To provide the distal end part of a lateral view type endoscope constituted so that a nozzle is integrally formed to an electric insulating block connecting a distal end part body and an insertion part flexible tube, the leakage of a fluid from the nozzle part is not generated even if there is a change in adhesion with the elapse time or the like and the washing capacity of an observation window is not lowered. SOLUTION: The outer periphery of the fluid passage 12 of a nozzle 11 is hermetically closed over the whole periphery thereof and a recessed part 1a is formed on the surface on the side facing to the nozzle 11 of the distal end part main body 1 and the nozzle 11 is fitted in the recessed part 1a to be bonded thereto.
Patent JP-2002196905-A (JP)
Title: Information processing unit and method, image forming device, and storage medium
Inventor: KAWAMOTO KOICHI
IPC: G06F3/12
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To attain complete elimination of conflict conditions by developing a rule of complementing a basic conflict management rule. SOLUTION: Basic processing for mutually matching setting conditions is performed and, to match the setting conditions, the rule of complementing the basic processing is developed (S501, S502). The setting conditions are matched in accordance with the basic processing and the complementing rule to determine control parameters based on the conditions (S507, S508).
Patent JP-2002193405-A (JP)
Title: Physical distribution system using contents confirmation tag and contents confirmation tag acquiring system
Inventor: INOUE HIROSHI
IPC: G06F19/00
Filed: 2000-12-25
Abstract: PROBLEM TO BE SOLVED: To provide a system capable of immediately confirming commodities at a commodity receiving place even when different commodities are delivered packed in different kind of box at a shipping place. SOLUTION: A department store 1 transmits the ordering instruction data Ai to a manufacturing company 3 handling ordered commodities, through a network 2 of the Internet or the like. The manufacturing company 3 prepares an ordering form on receiving the ordering data Ai, and executes the arrangement of the commodities such as collecting the commodities by the ordered amount on the basis of the ordering form, and putting the commodities in plural boxes. A physical distribution center of a transport company picks up the boxes including the commodities at the manufacturing company 3 to carry out the same, issues SCM labels 5i indicating the contents of the box (number, name of commodities or the like), attaches the SCM labels on the boxes, and loads the boxes in a vehicle to transport the same to the commodity receiving place of the department store 1. A two-dimensional bar code Hi of the SCM label 5i is scanned at the commodity receiving place in the department store 1 to confirm the contents and the number of commodities to complete the checking of the commodities.
Patent JP-2002194968-A (JP)
Title: Sash frame with shutter case
Inventor: SATO KEIICHIRO
IPC: E06B9/17
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To prevent outdoor cold air flowing into a shutter case from outside of the room from entering the room through a house wall. SOLUTION: A sash frame 10 includes the shutter case 20 on its upper portion, and an insulation panel 30 is secured to the shutter case via insulation panels 21c, 13c, and 11c disposed on the upper face plate 21 and side face plates 22 of the shutter case 20 and on the upper frame 11 of the sash frame 10. Consequently, because the shutter case 20 is mounted on the upper portion of the sash frame 10, when constructed, the shutter case 20 is secured within the retracted area which is continuous from the upper portion of the opening area of a house wall and which is open toward the outside of the room, width of the shutter case protruding from the house wall is reduced small, and good appearance of the house can be obtained. Furthermore, the outdoor cold air flowing into the interior of the shutter case 20 dose not flow into the room through the insulation panels, the cold air can be prevented from entering the room through the rest portion of the retracted portion of the house wall.
Patent JP-2002192542-A (JP)
Title: Method for manufacturing frp moldings
Inventor: NISHIYAMA MASAKI
IPC: B29C43/18
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a method for manufacturing FRP moldings with a presentably appearing decorative surface. SOLUTION: An FRP decorative material 21 previously molded and cured is laid on the inner faces of top and bottom forces (11 and 12), then an FRP body material 22 composed of a sheet molding compound(SMC) or a bulk molding compound(BMC) are deposited on the FRP decorative material 21 and both materials 21 and 22 are thermally molded under pressure. The FRP decorative material 21 is preferably a laminate of a colored gelcoat-cured surface layer and a resin-impregnated/cured fibrous sheet reinforcing layer or a laminate of a surface layer of the cured surface layer of the colored and patterned bulk molding compound(BMC) and the resin-impregnated/cured fibrous sheet reinforcing layer.
Patent JP-2002195273-A (JP)
Title: Bearing unit
Inventor: TAKEHARA TORU
IPC: F16C33/58
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a bearing unit capable of further improving durability and reliability. SOLUTION: A seizure resistant property of a bearing supporting a driving axle in a driving gear of a rolling stock can be considerably improved by using tapered roller bearings 113 and 114 whether it is starting time or running time. There are not any problems such as reduction of load rating and increase of a bearing size because the tapered roller bearings are the same as normal tapered roller bearings 13 and 14 except the position of rib portions 113d and 114d. Further, as adjustment of bearing clearance and assembling works to equipment can be done in a similar method as well as those of a conventional tapered roller bearing, a change of peripheral structure surrounding the bearings in the driving gear, introduction of new working facilities, and work training and the like can be minimized.
Patent JP-2002198198-A (JP)
Title: Electrostatics removal implement
Inventor: KURITA SHINYA
IPC: H05F3/02
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a electrostatics removal implement which can check a removal of the electrostatics by planner luminescence, in order to check the removal of the electrostatics without user making 3rd persons other than the user trouble. SOLUTION: The static electricity removing implement is constituted of a electrostatic input electrode and an electrostatic output electrode which are arranged by isolating in a hollow case which consists of an insulated material, and resistances connected in series between the electrostatic input electrode and the electrostatic output electrode. While arranging luminescence device which makes the above case emit a light, and a control circuit, which controls the luminescence time of the above luminescence device, is arranged, and when a potential difference is generated between the above electrostatic input electrode and the above electrostatic output electrode, the above control circuit inputted with the generating of the above potential difference makes the above luminescence device emit light.
Patent JP-2002191239-A (JP)
Title: Ceiling or wall structure
Inventor: SAITO MASAHIRO
IPC: A01G9/14
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a ceiling or wall structure that has improved insulation effectiveness and provide a ceiling or wall structure that reflects the light irregularly whereby the room is kept warm efficiently and uniformly and the light is allowed to reach the places to which the sunlight is hard to reach. SOLUTION: Heat insulation sheets 13 involving a plurality of gas-including closed cells 14 are arranged on at least a part of the ceiling and wall surfaces in a building.
Patent JP-2002200145-A (JP)
Title: Connector for nutritional catheter
Inventor: HIRAYAMA TOSHITATSU
IPC: A61J15/00
Filed: 2000-12-28
Abstract: PROBLEM TO BE SOLVED: To provide a connector for a nutritional catheter which does not generate a connection error with a connector used for other medical treatment purposes, and in addition, can be detachably connected with male type connectors of various sizes at a favorable sealability. SOLUTION: This connector for a nutritional catheter has a female type connecting port 12, which is fitted on the proximal end of the nutritional catheter 60 to be inserted in the body, and with which male type connectors 30a to 30e are detachably connected for feeding a nutritional agent. In this case, the internal wall of the connector constituting the female type connecting port 12 is constituted of a tapered internal wall, wherein the inner diameter becomes smaller into a tapered shape from the opening 14 of the female type connecting port to the distal end in the connector axial direction. On the tapered internal wall, a plurality of ring-shape sections 16 protruding inward are formed with a specified interval in the connector axial direction.
Patent JP-2002204542-A (JP)
Title: Permanent magnet for axial direction gap type motor, magnetizing method and apparatus for the magnet, axial direction gap type motor provided with the magnet
Inventor: YAMAGUCHI TADAO
IPC: H01F13/00
Filed: 2000-12-28
Abstract: PROBLEM TO BE SOLVED: To obtain, using a simplified method, a high-performance magnet having little non-magnetized portion reduced as much as possible and to employ a magnetization coil indicated by a heavy line, in order to provide a magnetizing apparatus for preventing the puncture of a yoke, and also to provide a high- performance axial direction gap type motor including such magnet. SOLUTION: A thin ring type axial direction gap permanent magnet (M) has four or more magnetic poles, which include rare earth metal and are arranged alternately in N and S poles in the outside diameter of 14 mm or less and the inside diameter of 4 mm or more. It if subjected to magnetization carried out in a manner such that the magnet is deviated to provide a cross-section of the non-magnetized portion of 8% or less for the total cross-section of magnet and the magnetization yokes (1, 11) are also deviated.
Patent JP-2001511481-A (JP)
IPC: C22C38/00
Filed: 1998-07-28
Abstract: An ultra-high strength essentially boron-free steel having a tensile strength of at least about 900 MPa (130 ksi), a toughness as measured by Charpy V-notch impact test at -40° C. (-40° F.) of at least about 120 joules (90 ft-lbs), and a microstructure comprising predominantly fine-grained lower bainite, fine-grained lath martensite, or mixtures thereof, transformed from substantially unrecrystallized austenite grains and comprising iron and specified weight percentages of the additives: carbon, silicon, manganese, copper, nickel, niobium, vanadium, molybdenum, chromium, titanium, aluminum, calcium, Rare Earth Metals, and magnesium, is prepared by heating a steel slab to a suitable temperature; reducing the slab to form plate in one or more hot rolling passes in a first temperature range in which austenite recrystallizes; further reducing said plate in one or more hot rolling passes in a second temperature range below said first temperature range and above the temperature at which austenite begins to transform to ferrite during cooling; quenching said plate to a suitable Quench Stop Temperature; and stopping said quenching and allowing said plate to air cool to ambient temperature.
Patent JP-2002517917-A (JP)
Title: パケット中継サービスにおけるデジタル伝送システムのデータ伝送のための方法
IPC: H04L12/56
Filed: 1998-07-29
Abstract: (57)【要約】
パケット中継サービスにおけるデジタル伝送システムのデータ伝送のための方法において、チャネル符号化のために送信側ではターボ符号器においてターボ符号化を実施し、受信側ではターボ復号器においてターボ復号化を軟判定出力信号によって実施する。ＡＲＱのトリガのために、チャネル品質はそれ自体周知のパラメータ推定方法によって推定され、ターボ復号器における軟判定出力信号の分散が算定され、チャネル品質及び分散から伝送されたパケットの正確さ乃至は誤りが推論され、誤りのあるパケットの少なくとも一部分の新たな送信がトリガされる。誤りのあるパケットの情報の再送信の際には、以前の送信の際にパンクチャリングによって抑圧された情報の少なくとも一部分が送信される。この付加的な情報は受信側で既存の情報に挿入され、この完全な情報が改めて復号化される。
Patent JP-2001522075-A (JP)
IPC: H04N17/00
Filed: 1998-10-27
Abstract: A method for downloading an executable application into a decoder 1 for a digital broadcast system, characterised in that the application is stored on a portable memory card introduced into a card reader 6, 7 in the decoder, the decoder reading and downloading the application from the card. Data may preferably be stored in the smartcard in a broadcast data format such as the MPEG format to permit the processing of such data in the same manner as the control unit 40 of the decoder processes data downloading by a broadcast transmission. The invention extends equally to a decoder and a memory card for use in such a method. <IMAGE>
Patent JP-2001524351-A (JP)
Title: 吸収性製品
IPC: A61L15/26
Filed: 1998-12-03
Abstract: (57)【要約】
本発明は、オムツ、成人失禁用衣類および女性用衛生製品のような吸収性製品に関する。さらに本発明は、呼吸性を与えるため、および装着者のためにより健康的な内部環境条件を促進するためにデザインされた外側カバーを有する吸収性製品に関する。より具体的には、本発明は、（ａ）トップシート；（ｂ）バックシート；および（ｃ）トップシートとバックシートとの間に位置する吸収性コアを具備し；バックシートは、非多孔質の、実質的に流体不透過性で水蒸気透過性の複合シート材を含む吸収性製品を提供する。好ましくは、複合シート材は、複合シート材のフィルム層が前記吸収性コアに向くように位置される。複合シートのフィルム層が実質的に親水性のエラストマーフィルム層を含む場合には、実質的に親水性のエラストマーフィルムは、好ましくは繊維質基材に接触して位置する。複合シートのフィルム層が、実質的に親水性のエラストマーフィルム層と実質的に疎水性のエラストマーフィルムとを有する多層フィルムを含む場合には、実質的に親水性のエラストマーフィルムは、好ましくは実質的に疎水性のエラストマーフィルムと繊維質基材との間に位置する。もう一つの態様において、フィルム層は、実質的に親水性のエラストマーフィルムと繊維質基材との間に位置する実質的に疎水性のエラストマーフィルムを含む第３の層をさらに含むことができる。吸収性製品は、使い捨てオムツを構成することができる。
Patent JP-2002504650-A (JP)
Title: 内燃機関起動前エンジンオイル予備加圧視認性濾過器
IPC: B01D35/00
Filed: 1999-02-25
Abstract: (57)【要約】
【課題】内燃機関が起動する前に貯留しているエンジンオイルを加圧循環させて起動の抵抗力を減少させ、機構の摩耗を低減させて、濾過品質を監視できる一種の内燃機関起動前のエンジンオイル予備加圧視認性濾過器を提供する。
【解決手段】  扁形直流モータ８、減速器９、オイルポンプ１０、チェックバルブ１３、油吸入ホース及びオイルスケール３、ペーパー濾材１１、ガラスカバー６と台座５からなる。扁形直流モータ８、減速器９、オイルポンプ１０、チェックバルブ吸油ホース１３と吸油ホース及びオイルスケール３をその順序で連結して、濾過器の上蓋部を構成する。中間部分が２ミクロン以下の不純物を濾過できるペーパ濾材１１を耐高温の強化ガラスカバー６中に付けて構成される。台座５は現有のオイルフィルターの台座と同じである。これら三つの部分はシーリングゴムパッキン４でパッキングしてから、ボルトで接続する。
Patent JP-2002506022-A (JP)
Title: 新脈管形成の阻害
IPC: A61K31/4425
Filed: 1999-03-12
Abstract: (57)【要約】
特定の単純な化学的薬剤（本明細書において、ニトロン関連治療剤または「ＮＲＴ」と称する）が、新生血管形成（新脈管形成）に感受性の患者に対して投与されるとき、その疾患の進行に介入および阻害し得る。１つ以上のＮＲＴを投与することによって新脈管形成を治療的および予防的に阻害するための方法が、そのような処置の方法における使用のための薬学的組成物と同様に開示される。これらの組成物および治療的方法において有用なＮＲＴもまた開示される。
Patent JP-2002507595-A (JP)
IPC: C07C319/24
Filed: 1999-03-16
Abstract: Compounds of the general formulawherein R represents a straight or branched chain alkyl group containing from 1 to 16 carbon atoms, pharmaceutically acceptable salts thereof and/or optical isomers thereof have an immunostimulating effect, and are useful in the treatment of arteriosclerosis.
Patent JP-2002508291-A (JP)
Title: 昇降路ドアシール構造体
IPC: B66B13/30
Filed: 1997-12-16
Abstract: (57)【要約】
エレベーターシステム（ここで、エレベーター箱は、エレベーター昇降路内の階間を移動する）を包含する高層建築物であって、これは、各階にて、廊下からのこの昇降路へのアクセスを提供するドアを含む。この昇降路へとまたはそこから煙および気体が通過するのを実質的に阻止するために、また、この昇降路に水が入るのを遮断するために、この昇降路ドアと昇降路壁構造体との間には、シール構造体が設けられている。横シール構造体は、壁取付部分、ドア部分を有し、この壁取付部分は、その昇降路壁に対して、角度付けされたシール係合面を備えており、そしてこのドア部分は、この昇降路壁に向かって面している角度付けされたシール接合面を備えており、そしてこの壁取付部分のシール係合面から離れて、間隔を空けて配置されている。このシール係合面とシール接合面との間には、シールが設けられて、その間の横空間を密封し、これらの昇降路ドアが閉鎖位置にあるとき、火災が発生した場合に、煙および気体がそこを通るのを阻止する。
Patent JP-2002527122-A (JP)
Title: 衛生器具
IPC: A46B5/02
Filed: 1999-03-31
Abstract: (57)【要約】
歯ブラシ用ハンドルを構成する細長い部品（１２）を備える、舌クリーナー（１０）が開示されている。２セットのリブ（４２，４４）が提供されている。リブセット（４２）は、細かいセットであり、他のリブセット（４４）は、粗いセットである。リブは、ハンドルを横切って伸びている。２つの側面（４８）は、舌掻き取りエッジ（４６）を形成するように結合する。陥没部（３６）は、部分的円形エッジを制限するように交差する内側及び外側湾曲側面により構成された円形エッジ（３８）により制限されている。
Patent JP-2002527240-A (JP)
Title: 湾曲したばね帯金区分を製造する方法および装置
IPC: B21D53/88
Filed: 1999-02-24
Abstract: (57)【要約】
区分長さにわたって可変な材料厚さを備えた、湾曲したばね帯金区分を製造する方法および装置では、トレランスの正確なかつ形状安定性を有する曲率半径を獲得するために、互いに間隔を置いて配置された３つの当付け箇所（２３〜２５）から成る曲げ加工ユニット（２０）と、ばね帯金（１０）の送り方向で見て、曲げ加工ユニットに後置された、第４の当付け箇所（３２）から成る曲戻し加工ユニット（２２）とがばね帯金（１０）によって通過され、曲げ加工および曲戻し加工されたばね帯金区分（１１）が分断ユニット（２１）でばね帯金（１０）から分断される。曲げ加工ユニット（２０）の真ん中の当付け箇所（２４）と、曲戻し加工ユニット（２２）の第４の当付け箇所（３２）とは移動可能に構成されていて、数値制御ユニット（２９）を用いて、予め設定されたプログラムに従って送り量をばね帯金（１０）に関連して制御している。
Patent JP-2003505744-A (JP)
Title: 情報の記憶および検索
IPC: G06T17/05
Filed: 1999-05-05
Abstract: (57)【要約】
位置に基く情報を記憶または検索、あるいはこの両者を実行する方法であって：複数の遠隔ユーザ端末から同時にアクセスできるデータメモリデバイスの分散形ネットワーク内に、どの情報メモリにアクセスできるかに関係している複数の第１の場所を定めるデータを記憶することと；前記第１の場所の１つを選定して、情報を記憶または検索、あるいはこの両者を行なう第２の場所を表わして、ｉ）前記第１および第２の場所が大きさにおいて所定の位置関係を示しており、ii）前記第１および第２の場所が大きさについての所定の関係を示していることとを含む方法。
Patent JP-2002514859-A (JP)
IPC: H04N21/2347
Filed: 1999-05-05
Abstract: A method and apparatus for distributed conditional access (CA) control on a serial communication network. An exemplary embodiment of the present invention includes a CA subsystem over a 1394 network, the CA subsystem comprising a receiver unit for receiving a digital broadcast signal (DBS) and OOB data from an external source, where the DBS and OOB data are transmitted from the external source to the receiver unit in different broadcast frequencies. The receiver unit comprises a main tuner subunit coupled to receive the DBS, which can be encrypted with respect to a first encryption scheme. The receiver unit also comprises an OOB tuner subunit coupled to receive the OOB data for decrypting the DBS with respect to the first encryption scheme. The CA subsystem also comprises a CA control unit coupled to the receiver unit, which in turn comprises a CA subunit coupled to receive the DBS and OOB data. If the DBS is encrypted with respect to the first encryption scheme, the CA subunit generates a descrambled signal from the DBS using the OOB data, such that said descrambled signal is no longer encrypted with respect to the first encryption scheme. Other embodiments of the present invention include the above and wherein the descrambled signal is encrypted with respect to a standard 1394 copy protection scheme, but not encrypted with respect to the first encryption scheme.
Patent JP-2002514721-A (JP)
IPC: F16F15/08
Filed: 1999-05-04
Abstract: An elastomeric mounting module (1) suitable for use as one of a pair of modules for forming an elastomeric mounting assembly (20) comprises two rigid end members (2, 3) of L-shape section and an element (4) of elastomeric material extending between and bonded to inwardly facing surfaces (10, 11) of the end members, respective bonded surface zones of the two rigid end members being offset at least in part as considered in the direction of normal compression loading and in a transverse direction perpendicular to said loading direction.
Patent JP-2002520016-A (JP)
Title: プレセニリン２特異的リボザイム
IPC: A61K48/00
Filed: 1999-07-08
Abstract: (57)【要約】
本発明は、神経変性性疾患およびアルツハイマー症におけるプレセニリン２の発現を阻害できる物質に関する。プレセニリン２特異的RNAを切断することのできるリボザイムについても開示されている。本発明は好ましくは、プレセニリン２特異的リボザイムおよび自己触媒的ハンマーヘッドリボザイムを含む融合リボザイムに関連する。さらに、このリボザイムをコードする組換えDNA分子、このリボザイムに対応するｃDNAを含む組換えベクター、およびこの組換えベクターを含む宿主細胞についても開示する。さらに、本発明は、前述の物質またはリボザイムまたは組換えベクターおよび医薬学的に許容可能なキャリアを含む医薬学的組成物に関する。本発明はまた、神経変性性疾患の治療またはアルツハイマー症の治療への上述した物質、またはリボザイム、または組換えベクターの使用を含む。