baber/WOPTO huggingface dataset:
Patent PT-1491208-E (PT)
Title: Stabilized liquid pharmaceutical compositions containing tfpi
Inventor: CHEN BAO-LU
IPC: A61P25/28
Filed: 2000-10-03
Abstract: Stabilized liquid pharmaceutical composition (I) comprising a polypeptide or its variant, an amino acid base comprising arginine, lysine, aspartic acid or glutamic acid and a buffering agent. New stabilized liquid pharmaceutical composition (I) comprises: (a) an active agent consisting polypeptide (or one of its variants), exhibiting aggregate formation during storage in a liquid formulation; (b) an amino acid base present in an amount sufficient to decrease aggregate formation of the polypeptide or its variant during storage of the composition, the amino acid base comprising at least one amino acid selected from arginine, lysine, aspartic acid and glutamic acid; and (c) a buffering agent selected from an acid free of its salt forms and/or an acid in its salt form. Independent claims are also included for: (1) a stabilized liquid pharmaceutical composition comprising interleukin-2 (IL-2) or one of its variants, arginine in its free base form (150-350 mM) and succinic acid substantially free of its salt form (80-190 mM); (2) a stabilized liquid pharmaceutical composition comprising tissue factor pathway inhibitor (TFPI) or one of its variants, arginine in its free base form (175-325 mM) and succinic acid substantially free of its salt form (80-190 mM); (3) a stabilized liquid pharmaceutical composition comprising tissue factor pathway inhibitor (TFPI) or one of its variants, arginine in its free base form (175-400 mM) and citric acid substantially free of its salt form (40-200 mM); and (4) a method for increasing the stability of a polypeptide or one of its variants in a liquid pharmaceutical composition, where the polypeptide or it variant exhibits aggregate formation during storage in a liquid formulation, by incorporating into the composition an amino acid base in an amount sufficient to decrease aggregate formation of the polypeptide or one of its variants and a buffer selected from acids free of their salt forms, acids in their salt forms and a mixture of an acids and its salt form, the amino acid base comprising at least one amino acid selected form arginine, lysine, aspartic acid and glutamic acid.
Patent PT-1594635-E (PT)
Title: System and method for treating fly ash
Inventor: TARDIF MARC-ANDRE
IPC: B09B3/00
Filed: 2004-01-22
Abstract: A method and system for treating fly ash with a treating fluid by evenly dispersing a treating fluid into a flowing stream of fly ash. By dispersing the treating fluid into the fly ash as the fly ash is flowing, the method takes advantage of natural mixing and particle motion that occurs during flow of the bulk solid. The application of treating fluid is advantageously controlled by an automated controller that has inputs and outputs that allow the controller to adjust flow rate of the treating fluid in correspondence with a measured flow rate of the fly ash.
Patent PT-1608708-E (PT)
Title: Mixtures of reactive dyes and their use
Inventor: TZIKAS ATHANASSIOS
IPC: C09B62/44
Filed: 2004-03-24
Abstract: Dye mixtures comprising at least one dye of formula together with at least one dye of formula wherein the radicals indicated in the formulae are defined in accordance with the claims, are suitable for dyeing or printing cellulosic fibre materials with good build-up behaviour and yield dyeings of a deep shade having good fastness properties.
Patent PT-1633008-E (PT)
Title: Plug (diagnostic probe) for a multi-cell battery
Inventor: SCHUMANN PETER
IPC: H01M10/48
Filed: 2003-12-03
Abstract: Soft sealing components (17, 18) intervene between core (2) and main body.
Patent PT-1678994-E (PT)
Title: Tractor with frame
Inventor: KUHLMANN IGNATZ
IPC: A01B51/02
Filed: 2005-12-21
Abstract: The tractor has a frame (1) in which a driver cabin is arranged, and an engine compartment arranged in front of the cabin. The frame has a section (6) projecting forward over the compartment. A retaining device (7) is arranged in the section and includes inset units (8, 8`) to retain operating devices designed as loading platform. The device has a centre section limiting the compartment, and two side frames bordering the compartment.
Patent PT-1853533-E (PT)
Title: Method for the consolidation of ornamental stones and relevant plant
Inventor: PEDRINI LUIGI
IPC: C04B41/50
Filed: 2005-02-24
Abstract: The method for consolidating plate-like, slice-like or modularelement-like ornamental stones comprises: the impregnation by means of the pressure created in the treatment environment with a water glass solution wherein the material being treated is plunged for enough time for the full penetration in fissures and microporosities of the surface thereof; characterised in that it has the following steps:-A pre-treatment of the material by exhausting;-A permanence of the pre-treatment step for enough time to extract gases, steams and powders existing in said fissures and microporosities;-An injection of the impregnating solution with a water glass solution and keeping the treatment chamber under vacuum during the injection and in the following impregnation step. The absolute pre-treatment pressure is preferably of 0.2-0.3 mbar; for the injection it is preferably between 10 and 100 mbar, while for the impregnation it is preferably kept at a pressure close to the steam pressure of the water glass solution being used. The implant being used and the device for the stowage and handling of the materials to be treated are also described.
Patent PT-1861105-E (PT)
Title: Process for the preparation of galanthamine hydrobromide
Inventor: GABETTA BRUNO
IPC: A61P25/28
Filed: 2005-11-23
Abstract: A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of the Amaryllidaceae family containing galanthamine, treatment of the hydrobromide with alkali, extraction and crystallization of galanthamine with a solvent of general formula (II), in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl. The resulting pure galanthamine can be conveniently used for the preparation of galanthamine hydrobromide.
Patent PT-1666604-E (PT)
Title: Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
Inventor: ANDERSON CHRISTOPHER J
IPC: C12N1/20
Filed: 2004-07-07
Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base condon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins and homoglutamines using these orthogonal pairs.
Patent PT-2044078-E (PT)
Title: Camptothecin derivatives with antitumor activity
Inventor: FONTANA GABRIELE
IPC: A61K31/4745
Filed: 2007-07-12
Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
Patent PT-2029572-E (PT)
Title: Organic compounds
Inventor: DALES NATALIE
IPC: C07D405/04
Filed: 2007-06-04
Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
Patent PT-2085203-E (PT)
Title: Folding container for transporting ice-cooled cargo
Inventor: RINGLER WERNER
IPC: B29C45/00
Filed: 2008-03-26
Abstract: The container has side walls and a base, which are produced by plastic injection molding. The side walls and/or the base have a double-walled construction with a closed air cushion, and discharge openings for discharging liquid i.e. melt water, is provided in the base. The double-walled construction is produced by a core during injection molding. The air cushion is closed, while a base unit is welded after withdrawing the core. Auxiliary openings are provided in hinges, which connects the base and side walls. An independent claim is also included for an injection mold for producing a folding container.
Patent PT-601630-E (PT)
Inventor: MERKSTEIJN JACOBUS LAMBERTUS V
IPC: B21B1/16
Filed: 1993-11-30
Abstract: The invention relates to metal rod (1) with a substantially round cross section comprising at least six rows (16,17) of ribs (11) arranged in the surface spread over the periphery, the surface of which is preferably provided with six rows of ribs (11) and the ribs (11) of at least one row are optionally arranged obliquely in the surface relative to the rod direction, wherein the ribs of adjoining rows of ribs are optionally oriented in herringbone form. <IMAGE>
Patent PT-701464-E (PT)
Inventor: VISSER LENA DE
IPC: A61N2/02
Filed: 1994-06-01
Abstract: PCT No. PCT/NL94/00125 Sec. 371 Date May 6, 1996 Sec. 102(e) Date May 6, 1996 PCT Filed Jun. 1, 1994 PCT Pub. No. WO94/27675 PCT Pub. Date Dec. 8, 1994The invention relates to a device for administering sound waves and/or at least one magnetic field to a patient, including a housing in which are accommodated a source for generating low-frequency sound waves, at least one source for generating a magnetic field and means for adjusting the frequency of the sound waves. The source for generating the sound waves is preferably formed by a speaker and the source for generating a magnetic field by a coil. The housing includes for instance a tube open on one side for passage of the sound waves and/or the magnetic field, wherein the means for concentrating the sound waves and/or the magnetic field are formed by a cover of the open side of the tube, in which the cover is provided with an aperture.
Patent PT-912412-E (PT)
Inventor: JORDI HANS ULRICH
IPC: B65D41/34
Filed: 1996-05-06
Abstract: The invention provides a safety seal device which includes a tear-off strip and a band section. The band section is subdivided into circular arc sections and U-shaped sections. The band section is provided with wedge-shaped locking elements. In addition, the band section is joined to the body of the screw cap via first breakaway webs. The U-shaped sections form spring elements in the band section thereby elastically suspending the locking elements. For this reason, the locking elements can elastically give when the screw cap is first screwed on, so that the safety closure cannot be plastically deformed when the screw cap is screwed on, which would jeopardize its security.
Patent PT-836591-E (PT)
Inventor: DIMMOCK JONATHAN RICHARD
IPC: A61P25/00
Filed: 1996-06-07
Abstract: A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system:   <IMAGE>   wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9 alkyl, C3-9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.
Patent PT-857158-E (PT)
Inventor: SCHUBERT DAVID M
IPC: C01B35/12
Filed: 1996-10-16
Abstract: An improved method is provided for producing crystalline calcium hexaborate tetrahydrate, synthetic nobleite, by the reaction of boric acid and lime in an aqueous slurry. Reaction conditions include boric acid to water molar ratios of greater than 0.25:1, lime to boric acid molar ratios in the range of 0.05-0.15:1 and temperatures in the range of 85 DEG -105 DEG  C. A novel crystalline product is produced having a unique crystal habit resulting in improved physical properties. Dehydration of this product produced a novel amorphous, anhydrous product having similar crystal habit and physical properties.
Patent PT-882138-E (PT)
Inventor: BAILEY MURRAY DOUGLAS
IPC: C07D213/40
Filed: 1996-12-17
Abstract: A highly efficient and practical means has been developed which enables compounds of the formula:   <IMAGE>   wherein R1 is lower alkoxy, lower alkylamino, di-(loweralkyl) amino, or the monovalent radical A-NR3, wherein A is lower alkyl or A is R4R5NC(O)CH2 wherein, for example, R4 is hydrogen or alkyl and R5 is hydrogen, alkyl or a substituted alkyl, or R5 is R6R7N-Alk wherein R6 and R7 each is hydrogen or lower alkyl and Alk is a divalent alkyl radical; R3 is, for example, benzyl, alkyl or a substituted alkyl; and R2 is, inter alia, alkyl, cycloalkyl, 1H-imidazol-4-yl, 4-thiazolyl or 2-amino-4-thiazolyl; to be prepared through the kinetic resolution of a compound of the formula:   <IMAGE>   wherein R1 is as defined herein, R2 is as defined herein, and B is lower alkyl. These compounds are useful intermediates in the synthesis of renin inhibiting compounds.
Patent PT-812556-E (PT)
Inventor: LAM PETER AR-FU
IPC: A47G25/44
Filed: 1995-02-20
Abstract: An adjustable garment hanger is disclosed having extension members which move laterally on a hanger frame (22). The extension members move as a result of engagement between a pair of racks (664,666) and medially disposed pinions (658,660). The movement paths of the racks (664,666) cross over each other side by side at a location proximate to a medial portion (650) of the hanger.
Patent PT-844071-E (PT)
Inventor: BUCHY MICHEL
IPC: B31F1/30
Filed: 1997-11-10
Abstract: The corrugating machine comprises a series of corrugating bars (6) fixed to a driven endless chain (5), and a series of supporting bars (13) for the material (10) being corrugated. The corrugating bars are able to move relative to the endless chain, their movements being perpendicular to the plane of the supporting bars. The supporting bars have additional bars beneath them on a second endless chain to hold them up while a pressure is applied by the corrugating bars and acting at the same time as drying elements.
Patent PT-913974-E (PT)
Inventor: BOUQUET HANSPETER
IPC: H04N7/16
Filed: 1997-10-31
Abstract: The method involves creating a database (6) containing multimedia objects (1, 20, 3) for transmission by broadcast channel. A transmission schedule (8) is created, including a list of multimedia objects selected from the database and transmission criteria (81) connected with the multimedia objects. The potential transmission criteria enable a time controlled transmission of objects, or a transmission based on random events. Independent claims are included for a transmission method for multimedia data, a programmable device, and a data memory.
Patent PT-883622-E (PT)
Inventor: KARIMIAN KHASHAYAR
IPC: A61K31/4439
Filed: 1997-02-26
Abstract: Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula:   <IMAGE>   where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is an electronegative group.
Patent PT-900453-E (PT)
Inventor: SHEN ZHI-YUAN
IPC: H01P7/08
Filed: 1997-05-16
Abstract: TM0i0 mode (i = 1, 2, 3 ...) planar high temperature supercondutor resonators useful in high temperature superconducting filters, filter banks and multiplexers comprise a shaped high temperature superconductor film and a high temperature superconductor ground plate deposited on opposite sides of a dielectric substrate, wherein the shaped high temperature superconductor film has an aperture in the center thereof and has a shape selected from the group consisting of circles and polygons.
Patent PT-902109-E (PT)
Inventor: SCHILLER PETER
IPC: D03D47/38
Filed: 1998-08-01
Abstract: The yarn selector feeders (15) and associated clamp (16) are levers swinging about a shaft (13). A fork (17) moves the feeders along the shaft to bring the selected feeder into the operating position. The fork (17) is guided by a slide (19). The yarn feeders are rotated by a drive through a crank (30) and moved along the shaft (13) by a drive (22) through a rack (25) and pinion (24) or an alternative lever mechanism. The yarn path includes a pneumatic yarn tensioning device.
Patent PT-960524-E (PT)
Inventor: SEREX PATRICK
IPC: H04N1/32
Filed: 1998-02-05
Abstract: A method for processing a digital image to obtain therefrom a photographic print which consists in transmitting a prerecorded image and data related to its processing to a data server connected to a data transmission network. The data server temporarily memorizes the received data. An image processor connected to an image recorder for recording a negative of the image to be processed on the data from the data server, formats them, and supplies to the image recorder the images to be processed preceded by a virtual image, identifying the user, for automatic processing by a standard filmline processor.
Patent PT-1124872-E (PT)
Inventor: SCHMALSTIEG LUTZ
IPC: C08G18/48
Filed: 1999-10-18
Abstract: This invention relates to polyurethane prepolymers which comprise alkoxysilane terminal groups and which are based on special, very high molecular weight polyurethane prepolymers, to a method of producing them and to their use as binders for low-modulus sealing materials.
Patent SG-19995-G (SG)
Title: Novel 3-arylindole and 3-arylindazole derivatives
Inventor: PERREGAARD JENS KRISTIAN
IPC: A61K31/40
Filed: 1995-02-07
Abstract: 3-Arylindole or 3-arylindazole derivatives having formula: <CHEM> wherein Ar is optionally substituted phenyl or a heteroaromatic group; R<1>-R<4> are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio;  the dotted lines designate optional bonds; X is N or a group CR<6> wherein R<6> is hydrogen, halogen, trifluoromethyl or alkyl, or X is CH2; Y is N or CH, or Y is C ; R<5> is hydrogen, cycloalkyl, cycloalkylmethyl, alkyl or alkenyl, optionally substituted with one or two hydroxy groups, or R<5> is a group taken from structures 1a and 1b : <CHEM> wherein n is an integer from 2 - 6; W is O or S; U is N or CH ; Z is -(CH2)m-, m being 2 or 3, -CH=CH- , 1,2-phenylene or -COCH2- or -CSCH2-; V is O, S, CH2, or NR<7>; U<1> is O, S, CH2 or NR<8>; and V<1> is NR<9>R<1><0>, OR<1><1>, SR<1><2> or CR<1><3>R<1><4>R<1><5>, and R<7>-R<1><5> are independently hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl ; may be prepared by methods known per se. The compounds are selective centrally acting 5-HT2-antagonists in the brain and are useful in treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, drug-induces Parkinsonism and Parkinson's disease.
Patent IE-32845-L (IE)
Title: Self-drying culvert
IPC: F16L57/00
Filed: 1969-02-20
Abstract: 1,267,542. Culverts. BPA BYGGPRODUKTION A.B. 1 March, 1969 [1 March, 1968], No. 7030/69. Heading E1C. [Also in Division F2] A culvert for unprotected pipes, e.g. 1a, carrying hot fluid, comprises a base plate 2 of permeable, heat insulating material, e.g. mineral wool, which is placed in the bottom of a trench, and a channel-sectioned cover 4 of heat insulating porous material arranged thereover in spaced relationship. The pipes are of corrosion-resistant material, e.g. stainless steel or plastics, and the base plate and cover of plastics-impregnated spun wool. The culvert is said to be self-drying. The pipes 1a, 1b may rest on spacers, or directly on the base plate, and a drain pipe 5 is preferably arranged underneath the base plate.
[GB1267542A]
Patent IE-780298-L (IE)
Title: Azetidinooxazines
IPC: C07D505/00
Filed: 1978-02-10
Abstract: Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: <IMAGE> wherein R is a monovalent group (minus the carbonyl) from an acyl group derived from a carboxylic or carbonic acid; Y1 is a divalent group of the following formula: <IMAGE> +TR <IMAGE> wherein COB is carboxy or protected carboxy; X is hydrogen or a nucleophilic group; and Z is a leaving group are prepared from a compound of the following formula: <IMAGE> wherein R and Y1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: <IMAGE> wherein A is amino or substituted amino; E is hydrogen or methoxy; and Y is a divalent group of the following formula: <IMAGE> in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in beta -lactam chemistry.
[US4366316A]
Patent IE-820338-L (IE)
Title: Azepines
IPC: C07D487/04
Filed: 1982-02-17
Abstract: Compounds of the formula <IMAGE> wherein n and m are each 1, 2 or 3, and the sum of n+m is 4; R1 is alkyl; alkenyl; unsubstituted, mono- or di-substituted aralkyl; unsubstituted, mono- or di-substituted benzoyl; alkoxycarbonyl; aralkoxycarbonyl; or, when m and n are each 2 and/or R2 and R3 are other than both hydrogen at the same time, also hydrogen; one of R2 and R3 is hydrogen or amino, and the other is carboxyl or alkoxycarbonyl; or, when R3 is hydrogen, R2 is hydrogen; amino; alkoxycarbonyl-amino; (unsubstituted or mono-substituted phenyl)-aminocarbonyl-; (unsubstituted or mono-substituted phenyl)ethylaminocarbonyl; azidocarbonyl; or hydrazinocarbonyl; X is oxygen, sulfur or <IMAGE> where R4 is hydrogen; alkyl; phenyl-alkyl; or phenyl; non-toxic, pharmacologically acceptable acid addition salts thereof; and, when R2 or R3 is carboxyl, non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antithrombotics.
[US4414225A]
Patent IE-820396-L (IE)
Title: Aerated drinks machine
IPC: B01F3/04
Filed: 1982-02-24
Abstract: An appliance for making an aerated beverage by introducing carbon dioxide under pressure into a bottle (29) partly filled with water, in which a support member (16) is pivotally mounted by a pivot (15) on the casing (10) and carries the shatterproof housing, (24), which surrounds the bottle, the nozzle (31), the stopper (27) and the container (18) of pressurized liquid carbon dioxide, so that these all pivot with the support member as a pivotal assembly. Such a construction can be made relatively inexpensively.
Patent IE-38978-L (IE)
Title: Polyurethanes.
IPC: C08G18/42
Filed: 1974-03-07
Abstract: 1458069 Polyurethanes GENERAL MILLS CHEMICALS Inc 16 April 1974 [16 April 1973] 16596/74 Heading C3R [Also in Division B2] Polyurethanes are prepared by chain extending a prepolymer having terminal isocyanate groups and being derived from a hydroxylic component comprising at least 20 equivalent per cent of a hydroxy terminated ester of a polymeric fat acid which comprises at least 80% dimeric fat acid as determined by gas-liquid chromatography with a diamine or a diol. The polymeric fat acid may be obtained by polymerizing ethylenically unsaturated aliphatic monocarboxylic acids having 16 to 22, preferably 18 carbon atoms. Such polymeric fat acids may be reacted with glycols containing 2 to 10 carbon atoms to provide esters which are monomeric or polymeric in nature. The esters, optionally in admixture with aliphatic diols, polyethers, polyesterethers or polyesters, are then reacted with an organic polyisocyanate to form a prepolymer which is subsequently chain extended with the diol or diamine. The chain extension reaction may be carried out in solution in an organic solvent. Glass containers may have their exterior surfaces coated with the chain extended prepolymers (see Divisions B1/B2).
[GB1458069A]