baber/WOPTO huggingface dataset:
Patent WO-2019006107-A1 (WO)
Title: Modified ube3a gene for a gene therapy approach for angelman syndrome
Inventor: NASH KEVIN RON
IPC: C12N15/85
Filed: 2018-06-28
Abstract: A novel vector, composition and method of treating a neurological disorder characterized by deficient UBE3A is presented. The UBE3A gene, which encodes for E6-AP, a ubiquitin ligase, was found to be responsible for Angelman syndrome (AS). A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In the majority of AS cases, there is a mutation or deletion in the maternally inherited UBE3A gene, although other cases are the result of uniparental disomy or mismethylation of the maternal gene. A UBE3A protein construct was generated with additional sequences that allow the secretion from cells and uptake by neighboring neuronal cells. This UBE3A vector may be used in gene therapy to confer a functional E6-AP protein into the neurons and rescue disease pathology.
Patent WO-2019010227-A1 (WO)
Title: Enhanced inorganic coagulants for wastewater treatment
Inventor: HENDERSON WILLIAM
IPC: C02F101/14
Filed: 2018-07-03
Abstract: A method for treating water to remove a target analyte that includes adding to the water a rare earth metal salt and a coagulant, and then removing the target analyte from the water. The treatment composition can be added as a blend that includes die coagulant and the rare earth metal salt.
Patent WO-2019023494-A1 (WO)
Title: Surgical stabilizer aligner
Inventor: MORTON JOHN Y
IPC: A61C7/08
Filed: 2018-07-26
Abstract: Embodiments relate to aligners that are capable of immobilizing a patients jaw after orthognathic surgery while also applying forces to reposition a patients teeth. In embodiments, a processor determines, for a treatment stage, a dentition for an upper dental arch and a lower dental arch. The processor applies one or more stabilizing features to the upper dental arch and the lower dental arch. The processor determines whether the one or more stabilizing features will prevent jaw movement while the upper dental arch is engaged with the lower dental arch. Responsive to a determination that the one or more stabilizing features will prevent the jaw movement, the processor stores a first digital model comprising the dentition for the upper arch and the one or more stabilizing features for the upper arch and stores a second digital model comprising the planned dentition for the lower arch and the one or more stabilizing features for the lower arch for each increment of treatment.
Patent WO-2019023522-A1 (WO)
Title: System and mechanism for upselling products on autonomous vehicles
Inventor: FERGUSON DAVID
IPC: G06Q10/08
Filed: 2018-07-26
Abstract: Provided herein is an autonomous or semi-autonomous vehicle fleet comprising a plurality of autonomous or semi-autonomous vehicles for containing, securing, and delivering at least one of a first item and at least one of a second item after a customer places an order for a first item, operating autonomously or semi-autonomously, and a fleet management module for coordination of the autonomous or semi-autonomous vehicle fleet.
Patent WO-2019023696-A1 (WO)
Title: Hardware and software mechanisms on autonomous vehicle for pedestrian safety
Inventor: FERGUSON DAVID
IPC: B60R19/22
Filed: 2018-07-30
Abstract: An autonomous robot vehicle includes a front side and an energy absorbing system. The front side includes a front bumper and a front face including a frame defining a cavity. The energy absorbing system includes an energy absorbing member mounted in the cavity of the frame, and an inflatable airbag. The energy absorbing member is configured to reduce impact on an object struck by the autonomous robot vehicle. The inflatable airbag is mounted on the front side of the autonomous robot vehicle such that when the inflatable airbag is deployed, the inflatable airbag is external to the autonomous robot vehicle.
Patent WO-2019032675-A1 (WO)
Title: Chimeric antigen receptor mediated cell targeting
Inventor: CONWAY ANTHONY
IPC: C12N15/90
Filed: 2018-08-08
Abstract: Disclosed herein are methods and compositions for engineering cells to express a CAR where the cells also have inactivated TCR, HPRT, PD1, CISH and/or HLA genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided.
Patent WO-2019055255-A1 (WO)
Title: Liquid hand dishwashing cleaning composition
Inventor: BILLIAUW JAN
IPC: C11D1/83
Filed: 2018-09-05
Abstract: The present invention relates to a liquid hand dishwashing cleaning composition including a surfactant system, wherein the surfactant system includes an anionic surfactant and a co-surfactant, wherein the anionic surfactant includes a mixture of a linear anionic surfactant and a branched anionic surfactant with a defined degree of branching and with the branching predominantly on an unalkoxylated alkyl sulfate surfactant. Such compositions exhibit surprising and unexpected improved sudsing profile, preferably stable suds, especially when the manual dishwashing is performed in a sink full of water with the cleaning composition diluted in it.
Patent WO-2019135803-A1 (WO)
Inventor: ANAGNOST JOHN
IPC: G01D5/20
Filed: 2018-09-19
Abstract: An eddy current displacement sensor includes devices or modules for digitizing and interpreting analog signals received from sensor coils. Periodic analog signals, such as sinusoidal or square wave signals, are sent to the coils with a suitable frequency. The output from the coils is then digitized using one or more analog-to-digital converters, at a sampling rate (frequency) that may be greater than that of the frequency of the input signal. The digitized output signals may then be processed to determine displacement of an object relative to the sensor coils, for example using magnitude and/or phase of the digital signals to estimate position. Digitizing the analog output signals directly, rather than only after such signals have been converted to DC signals, allows improvement in processing, as well as enabling flexibility in how the signals are used to estimate position.
Patent WO-2019067442-A1 (WO)
Title: DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS
Inventor: BECK HILARY PLAKE
IPC: A61K31/4365
Filed: 2018-09-25
Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.
Patent WO-2019079670-A1 (WO)
Title: Support structures for automated footwear platform
Inventor: AVAR ERIC P
IPC: A43C11/24
Filed: 2018-10-19
Abstract: Systems and apparatus related to an automated footwear platform including an actuator assembly for controlling a footwear lacing apparatus are discussed. In an example, an actuator assembly can include an actuator frame with a plurality of integrated actuators. The actuator frame is adapted to interconnect elements of the actuator assembly, the actuator frame including a width, a length, and a thickness where the width and length form an exterior surface and an interior surface separated by the thickness. The plurality of actuators are integrated into the actuator frame, each actuator of the plurality of actuators including an actuator head extending from the exterior surface and a button interface extending from the backside of the actuator head through the interior surface.
Patent WO-2019089953-A1 (WO)
Inventor: MOHAPATRA NRUSINGH PRASAD
IPC: C12N15/113
Filed: 2018-11-01
Abstract: L'invention concerne des compositions pour le traitement d'infections bactériennes à gram positif et l'inhibition de la croissance de bactéries à gram positif. Les compositions comprennent un acide nucléique peptidique lié à un peptide de pénétration cellulaire (ANP-PPC). Le conjugué ANP-PPC et les compositions associées inhibent l'expression de protéines bactériennes et sont éventuellement administrées sous la forme de compositions nanoparticulaires et de tissus antimicrobiens.
Patent WO-2019112757-A1 (WO)
Inventor: VALLDEPERAS JACOB GIL
IPC: C08G18/32
Filed: 2018-11-13
Abstract: The present invention relates to novel thermoplastic polyurethane compositions made from the reaction product of an isocyanate component comprising hexamethylene-1,6-diisocyanate, a polyol component, and a chain extender component comprising an alkylene substituted spirocyclic compound. The present invention provides for thermoplastic polyurethane compositions which is resistant to chemical degradation and stains.
Patent WO-2019094934-A1 (WO)
Inventor: ANDREWS IAN PAUL
IPC: C07C39/21
Filed: 2018-11-13
Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl- trans -stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl- trans -stilbene is prepared from ( E )-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl- trans -stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.
Patent WO-2019108523-A1 (WO)
Inventor: PERKINS KEITH
IPC: A61F2/07
Filed: 2018-11-27
Abstract: De manière générale, la présente divulgation concerne des techniques pour prothèse comprenant un matériau de greffe à fils biodégradables en cadre comportant un cadre et des fils biodégradables combinés avec le cadre. Les fils biodégradables scellent les ouvertures d'intégration tissulaire à l'intérieur du cadre. Le cadre fournit une résistance mécanique à long terme tandis que les fils biodégradables fournissent une résistance et une imperméabilité pointues pour empêcher les endofuites. Au fur et à mesure que les fils biodégradables se dégradent, la chute de densité textile crée des ouvertures d'intégration tissulaire, à travers lesquelles le tissu croît. L'intégrat de tissu dans le matériau de greffe à fils biodégradables en cadre permet la fixation biologique de la prothèse dans des vaisseaux et empêche les endofuites et une migration de la prothèse.
Patent WO-2019112877-A1 (WO)
Title: Traceurs non radioactifs permettant d'évaluer des procédés de fracturation
Inventor: ZHANG QIANMEI
IPC: E21B47/085
Filed: 2018-11-29
Abstract: L'invention concerne un procédé d'évaluation de fractures provoquées dans un puits de forage, ledit procédé consistant à obtenir un premier ensemble de données dans un puits de forage à l'aide d'un outil de diagraphie de fond de trou. Un premier agent de soutènement est pompé dans le puits de forage, après la capture du premier ensemble de données. Le premier agent de soutènement comprend un premier traceur non radioactif. Un second agent de soutènement est également pompé dans le puits de forage, après que le premier agent de soutènement a été pompé dans le puits de forage. Le second agent de soutènement comprend un second traceur non radioactif, le second traceur étant différent du premier traceur. Un second ensemble de données est obtenu dans le puits de forage à l'aide de l'outil de fond de trou après que les premier et second agents de soutènement ont été pompés dans le puits de forage. Les premier et second ensembles de données sont comparés.
Patent WO-2019113260-A1 (WO)
Title: Cibles génomiques d'inhibiteurs de l'histone désacétylase (hdaci) et leurs méthodes d'utilisation
Inventor: LIU XUEDONG
IPC: C12N9/96
Filed: 2018-12-05
Abstract: La présente invention concerne, selon certains aspects, des transcrits sensibles à la dose d'inhibiteur de la HDAC, des amplificateurs, des super-amplificateurs et des ARN non codants et des compositions associées, des méthodes et des agents qui sont utiles pour cibler des gènes qui sont responsables de la prolifération, de la différenciation et de la mort des cellules cancéreuses destinés à des thérapies anticancéreuses.
Patent WO-2019133935-A1 (WO)
Inventor: HIGGINS MATTHEW
IPC: H04M1/00
Filed: 2018-12-28
Abstract: L'invention concerne un procédé de surveillance de procédures effectuées sur un équipement, le procédé comportant les étapes consistant à; associer une pluralité de codes à barres, chacun des codes à barres étant associé à un composant parmi une pluralité de composants, la pluralité de composants étant associée à un équipement, établir au moins une procédure associée à chaque code de la pluralité de codes à barres par rapport au composant associé, identifier un premier code à barres scruté par un dispositif de capture d'images, identifier au moins une procédure associée au premier code à barres, fournir au moins une ou plusieurs étapes associées à la ou aux procédures, recevoir confirmation de la ou des procédures à effectuer, déterminer la confirmation de l'achèvement d'au moins une étape de la ou des procédures, déterminer si la procédure identifiée a été achevée, et générer un compte rendu sur la base de la procédure identifiée achevée.
Patent WO-2019147504-A1 (WO)
Title: Cardiac valve delivery devices and systems
Inventor: GREGG PETER
IPC: A61M29/00
Filed: 2019-01-18
Abstract: A prosthetic valve delivery device includes a handle and a delivery catheter. The delivery catheter includes a central elongate member extending from the handle and a proximal sheath configured to slide over and relative to the central elongate member. The proximal sheath is connected to a hollow helical strand, and the hollow helical strand is configured to rotate to retract the proximal sheath and expose at least a portion of the prosthetic valve.
Patent WO-2019152849-A1 (WO)
Title: Channel charting in wireless systems
Inventor: STUDER CHRISTOPH
IPC: H04W72/04
Filed: 2019-02-01
Abstract: A processing platform in illustrative embodiments comprises one or more processing devices each including at least one processor coupled to a memory. The processing platform is configured to extract channel features of a wireless channel of a wireless system from channel state information characterizing a radio geometry of the wireless channel, to generate a forward charting function that maps the extracted channel features to a channel chart characterizing a representational spatial geometry of the wireless channel, and to utilize the channel chart to estimate at least one position-related characteristic of one or more wireless devices in an actual spatial geometry of the wireless channel. Generating the forward charting function illustratively comprises performing an unsupervised learning process to learn the forward charting function from the extracted channel features. The channel chart is illustratively configured to preserve local geometry of multiple spatial locations associated with the extracted features in the actual spatial geometry of the wireless channel.
Patent WO-2020162921-A1 (WO)
Title: Circuit intégré à circuits d'attaque d'adresse pour puce fluidique
Inventor: LINN SCOTT A
IPC: B41J2/045
Filed: 2019-02-06
Abstract: Un circuit intégré pour une puce fluidique comprend un bus d'adresse pour communiquer un ensemble d'adresses, un premier groupe de fonctions de configuration de puce comprenant un premier circuit d'attaque d'adresse pour attaquer une première partie d'une adresse de l'ensemble d'adresses sur le bus d'adresse, un second groupe de fonctions de configuration de puce comprenant un second circuit d'attaque d'adresse pour attaquer une seconde partie de l'adresse de l'ensemble d'adresses sur le bus d'adresse, et un réseau de dispositifs d'actionnement de fluide adressables par l'ensemble d'adresses communiquées par l'intermédiaire du bus d'adresse.
Patent WO-2019160980-A1 (WO)
Title: Derivatives of sobetirome
Inventor: SCANLAN THOMAS
IPC: A61K31/19
Filed: 2019-02-13
Abstract: Compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation. Such compounds have the structure of Formula (I) as shown herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof.
Patent WO-2019165197-A1 (WO)
Title: Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants
Inventor: MARKERT MARY LOUISE
IPC: A61L27/00
Filed: 2019-02-22
Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.
Patent WO-2019169253-A1 (WO)
Title: Source de plasma micro-onde destinée à un outil de traitement de dépôt de couche atomique activé par plasma (pe-ald) spatial
Inventor: KUDELA JOZEF
IPC: H01J37/32
Filed: 2019-03-01
Abstract: L'invention porte sur des ensembles sources de plasma, sur des ensembles de distribution de gaz comprenant un tel ensemble source de plasma et sur des procédés de génération d'un plasma. Les ensembles sources de plasma comprennent une électrode alimentée avec une électrode de masse adjacente à un premier côté et un diélectrique adjacent à un second côté. Un premier générateur de micro-ondes est couplé électriquement à la première extrémité de l'électrode alimentée par l'intermédiaire d'une première alimentation, et un second générateur de micro-ondes est couplé électriquement à la seconde extrémité de l'électrode alimentée par l'intermédiaire d'une seconde alimentation.
Patent WO-2019178480-A1 (WO)
Title: Pyrazole-containing macrophage migration inhibitory factor inhibitors
Inventor: JORGENSEN WILLIAM L
IPC: A61K31/192
Filed: 2019-03-15
Abstract: In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.
Patent WO-2020197541-A1 (WO)
Inventor: KENNEDY ANDREW
IPC: C07D239/47
Filed: 2019-03-22
Abstract: Provided herein, in some embodiments, are cytosine analogs, compositions comprising cytosine analogs, and methods of use for inhibiting a Ten-eleven translocation (TET) enzyme.
Patent WO-2019212746-A1 (WO)
Inventor: FARID MICHAEL
IPC: A47J27/14
Filed: 2019-04-16
Abstract: La présente invention concerne un système de chauffage et de mélange robotisé qui chauffe ou cuit et mélange automatiquement les ingrédients d'un repas ou d'une entrée dans un pot de chauffage qui réchauffe ou cuit les ingrédients d'une manière ressemblant à un wok et qui est automatiquement cardanné entre une position de chargement pour charger les ingrédients, une orientation de cuisson et de mélange : une orientation de service pour distribuer les ingrédients chauffés ou cuits à une plaque ou à un bol ou à un autre récipient, et une orientation de nettoyage.
Patent WO-2019204653-A1 (WO)
Title: Inner ear drug delivery devices and methods of use
Inventor: SACHERMAN KEVIN
IPC: A61F11/00
Filed: 2019-04-18
Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.
Patent WO-2020033020-A1 (WO)
Title: A secure method to replicate on-premise in a computing environment
Inventor: HUANG FENG
IPC: H04L29/06
Filed: 2019-04-29
Abstract: Systems and methods for secure sharing of sensitive information in a computing environment. The methods comprise, by a first entity of a first computing environment receiving sensitive information of the first computing environment, receiving a request to share the sensitive information from a second entity of the first computing environment, and determining whether the second entity is a trusted entity included in a list of trusted entities held by a configuration service associated with a second computing environment. If the second entity is not a trusted entity, determining whether the second entity can establish trust by validating a subscription of the second entity with a directory service, and validating a digital certificate corresponding to the second entity with a certificate authority. If the second entity can establish trust or is a trusted entity, sharing the sensitive information with the second entity so as to enable operation of the second entity.
Patent WO-2019222467-A1 (WO)
Title: Self-supervised training of a depth estimation system
Inventor: GODARD CLÉMENT
IPC: G06T7/00
Filed: 2019-05-16
Abstract: A method for training a depth estimation model and methods for use thereof are described. Images are acquired and input into a depth model to extract a depth map for each of the plurality of images based on parameters of the depth model. The method includes inputting the images into a pose decoder to extract a pose for each image. The method includes generating a plurality of synthetic frames based on the depth map and the pose for each image. The method includes calculating a loss value with an input scale occlusion and motion aware loss function based on a comparison of the synthetic frames and the images. The method includes adjusting the plurality of parameters of the depth model based on the loss value. The trained model can receive an image of a scene and generate a depth map of the scene according to the image.
Patent WO-2020009751-A1 (WO)
Title: Secure low power communications from a wireless medical device to multiple smartphones
Inventor: WASILY NABIL
IPC: H04W8/00
Filed: 2019-05-22
Abstract: Methods, systems, devices and apparatuses for secure low power communication. The secure lower power communication system includes a medical device and one or more mobile devices. The medical device includes a memory, a network access device and one or more processors. The network access device has multiple hardware device addresses. The multiple hardware devices addresses include a first address and a second address. The network access device is configured to wirelessly communicate with a mobile device. The medical device includes one or more processors coupled to the memory and the network access device. The one or more processors are configured to execute instructions stored in the memory and perform operations. The operations include establishing a first secure communication channel between the medical device and an application using the first address. The operations include transmitting advertising packets to remain discoverable by the application using the second address.