baber/WOPTO huggingface dataset:
Patent EP-1015051-B1 (EP)
Inventor: TCHOLAKIAN ROBERT
IPC: A61M25/00
Filed: 1996-06-05
Granted: 2004-12-22
Abstract: L'invention concerne généralement des dispositifs médicaux à demeure, et en particulier un dispositif fabriqué dans une matière perméable ou imperméable comprenant un agent pharmacologiquement actif (7) ou une couche de principe actif (3)(10) entourant le dispositif, et une gaine (2)(11) perméable à l'agent pharmacologiquement actif ou au principe actif. Ainsi, on produit un dispositif permettant à l'agent pharmacologiquement actif ou au principe actif situé entre le tube (1) de cathéter et la gaine (2) de se diffuser lentement à travers la gaine et/ou le tube interne (4), et d'inhiber toute infection microbienne sur la surface externe et dans la lumière du cathéter (5)(13).
Patent EP-0832137-B1 (EP)
Inventor: LEUNG JEFFREY C
IPC: B05D1/26
Filed: 1996-06-05
Granted: 2002-02-13
Abstract: An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.
Patent EP-0830949-B1 (EP)
Inventor: NAGAHATA TAKAYA
IPC: B41J2/345
Filed: 1996-07-30
Granted: 2002-11-06
Abstract: La présente invention concerne une tête d'impression thermique linéaire destinée à un système d'impression tel qu'un télécopieur et réalisée de manière à améliorer la qualité d'un document imprimé grâce à la réduction des différences de densité entre ses parties. La facilité de montage l'un sur l'autre de la tête d'impression thermique linéaire et d'un connecteur correspondant est améliorée. Une résistance de chauffage (2), un câblage classique (3), des câblages individuels (4), des éléments (5) du circuit de pilotage et un câblage (7) de mise à la terre s'étendent d'une façon linéaire sur une surface d'une plaque de base (1) de la tête. Une borne (8) de branchement du câblage de terre, qui est reliée électriquement à une partie intermédiaire sensiblement longitudinale du câblage de terre, se trouve sur la partie de la surface de la plaque de base de la tête qui est dans une partie généralement intermédiaire d'une zone latérale du câblage de terre de celle-ci. Deux bornes (12, 13) de branchement du câblage commun, qui sont reliées électriquement aux deux extrémités du câblage commun, se trouvent sur les deux côtés extérieurs de la borne de branchement du câblage de terre.
Patent EP-0871473-B1 (EP)
Inventor: FERGUSON MARK WILLIAM JAMES
IPC: A61P17/02
Filed: 1996-08-08
Granted: 2002-12-18
Abstract: The present invention provides IL-10 or a fragment or a partially modified form thereof for use in promoting the healing of wounds and fibrotic disorders with reduced scarring and methods for same.
Patent EP-0804048-B1 (EP)
Inventor: GEISENBERGER STEFAN
IPC: H04R9/06
Filed: 1997-04-03
Granted: 2008-10-29
Abstract: The loudspeaker (10) has at least one radially magnetised permanent magnet (12), supported by a mounting made of a paramagnetic or diamagnetic material, which may be provided in one piece with the loudspeaker cone which is made of a metal or metal alloy. The permanent magnet can be provided by a ring positioned between 2 identical loudspeaker membranes (13,13'), with a common oscillation coil body (15) at the centre of the permanent magnet.
Patent EP-0803428-B1 (EP)
Inventor: BETTINI BRUNO
IPC: E02F9/02
Filed: 1997-04-10
Granted: 2002-07-03
Abstract: A crawler track vehicle with retractable sides (5) comprises a central body (1) fitted with actuators for slidably moving a plurality of retractable transverse beams (4) each having an end portion (4a) secured to a crawler track side (5). The end portions (4a) are provided with means for releasably coupling to corresponding seats (5a) provided in the crawler track sides (5). The crawler track vehicle is capable of reaching a passive or transportation arrangement in which the beams are retracted towards the inside of the central body (1) by the actuators and the crawler track sides (5) are detached from the beams (4).
Patent EP-0833065-B1 (EP)
Inventor: FISCHER ARTUR PROF DR H C DR-I
IPC: F16B13/14
Filed: 1997-07-04
Granted: 2000-03-15
Abstract: The plastic dowel has a fabric sleeve and a channel for a fastening screw. The screw channel (3) is conically shaped over part of its length, in adaptation to the nozzle (9) of a spray device (10), which injects mortar into it. At the front insertion end (14) of the dowel, the channel is sealed by an injection skin (15). The channel has an internal stop (8) to limit the insertion movement of the nozzle. A shaft inside the dowel has outlet (11) for the injected mortar, and these are positioned in the front section of the dowel, and at the end of the conical section (6) of the screw channel.
Patent EP-0899289-B1 (EP)
Inventor: KNORR HERBERT
IPC: C08J3/24
Filed: 1997-08-29
Granted: 2004-11-03
Abstract: A novel method produces moulding masses from binders, fillers and/or fibres, with additives as appropriate. The binders are resin or resin-hardener mixtures. These can be hardened at a catalytic initiation temperature, above the m.pt.. In the new procedure, the filler and additives, and if appropriate, the hardener, are premixed in a fast mixer. Into this mixture, the resin or binder mixture is introduced, this is at least partially molten. Intensive mixing follows and the temperature in the mixer remains under the catalytic initiation temperature of the hardening reaction.
Patent EP-0846582-B1 (EP)
Inventor: ELTERLEIN PAUL
IPC: B60H1/26
Filed: 1997-11-21
Granted: 2004-02-11
Abstract: An insert section(3) is equipped with an air passage opening(9) and fits in the cut-out in the wall of the vehicle. A ventilator housing(13) is rotatable by 180 degrees on the insert section, and respective means(15,16) are provided to fix the ventilator housing in one of the rotated positions. The ventilator housing is rotationally fixed on a ventilator shaft(12) which is mounted in a hub(11) in the insert section and carries a twist grip(14) on its inner end.
Patent EP-0835868-B1 (EP)
Inventor: HAUSER KENNETH LEE
IPC: A61P35/00
Filed: 1997-10-09
Granted: 2001-08-29
Abstract: The present invention provides pharmaceutically active compounds formula I <CHEM> or a pharmaceutically acceptable salt or solvate thereof having activity as selective estrogen receptor modulators, pharmaceutical compositions containing the compounds, and methods of using formula I compounds for treating conditions resulting from estrogen deprivation or the inappropriately high presence of estrogen. Also provided are methods and chemical intermediates for the production of compounds of formula I above.
Patent EP-0792883-B1 (EP)
Inventor: DE NANTEUIL GUILLAUME
IPC: A61P7/02
Filed: 1997-02-27
Granted: 2000-12-20
Abstract: Boronic acid derivatives of formula (I), their isomers and their acid and base addition salts are new. R1, R2 = H or 1-6C alkyl; or CR1R2 = 3-8C cycloalkyl; R3 = H, 1-6C alkyl or phenyl or benzyl (both optionally substituted); R4 = heterocyclyl, amino, amidino, guanidino isothioureido iminomethylamino or mercapto (all optionally substituted); R5, R6 = H or 1-6C alkyl; or B(OR5)(OR6) = boronic ester of pinanediol; m = 0-6; n = 1-6; A1 = -CO-, -CS- or -SO2-; A = 5-10C bicycloalkyl-phenyl (optionally substituted) or -A2-N(R7)(R8), provided that m is not 0; A2 = -CO- or -CS-; R7, R8 = H, 1-6C alkyl (optionally substituted), 1-6C alkylsulphonyl, arylsulphonyl, aryl, heterocyclyl or 5-10C bicycloalkyl-phenyl (optionally substituted), indanyl or a group of formula (i) or (ii); Ra = 1-6C alkyl or phenyl (optionally substituted); Rb, Rc = H, halo, 1-6C alkyl, 1-6C alkoxy, hydroxy, optionally substituted amino or trihalomethyl.
Patent EP-0918523-B1 (EP)
Inventor: SNORRASON ERNIR
IPC: A61K31/407
Filed: 1997-02-19
Granted: 2003-02-05
Abstract: The present invention relates to the use of pharmaceutically acceptable cholinesterase inhibitors for the preparation of a pharmaceutical composition for the treatment or prophylaxis of arthritic disorders, including osteoarthritis, rheumatoid arthritis and other rheumatoid diseases such as Juvenile Arthritis, Systemic Lupus Erythematosis, Sjogren's Syndrome, Progressive Systemic Sclerosis, Polymyositis, Dermatomyositis, Ankylosing Spondilitis, Reiter's Syndrome, Psoriatic Arthritis, Relapsing Polychondritis, Relapsing Panniculitis, Crohn's Disease, Ulcerative Colitis, Heredity Complement Deficiencies, Collagen Vascular Diseases, Felty's Syndrome, rheumatological manifestations associated with bacterial and viral endocarditis or myocarditis and other rheumatological manifestations such as anaemia of chronic disorders. The invention also relates to a novel method of treatment or prophylaxis of such diseases and manifestations. Preferably, the cholinesterase inhibitors are selected from a group of nicotinic acetylcholinesterase inhibitors such as galantamine (the name of this drug was previously spelled galanthamine).
Patent EP-0880860-B1 (EP)
Inventor: INDEKEU JACK P
IPC: H04M3/42
Filed: 1997-02-13
Granted: 2008-01-02
Abstract: Emetteur-récepteur d'appel sélectif (200) comportant plusieurs points d'accès (246) d'adresse attribuables, un récepteur (204) permettant de recevoir un répertoire de services d'information (120, 132) sur un point d'accès d'adresse de postage, un contrôleur (210) produisant un menu (240) à partir d'un répertoire de services d'information (120, 132), un affichage (228) permettant d'afficher le menu (240) des services d'information à partir des multiples points d'accès d'adresse attribuable (246) et une interface utilisateur (216) permettant de sélectionner un service d'information (242) à partir du menu (240) de services d'information. Le contrôleur (210) est en outre relié à l'interface utilisateur (216) pour assigner le service d'information en cours de sélection au point d'accès d'adresse attribuable qui a été identifié, et à un émetteur (208) qui émet une demande de service d'information sélectionné (242) incluant une adresse permettant d'identifier un point d'accès d'adresse selectionnable.
Patent EP-0934669-B1 (EP)
Inventor: BERGKVIST BENGT
IPC: H04W36/04
Filed: 1997-10-15
Granted: 2005-05-04
Abstract: Selon la présente invention, on affecte à un réseau mobile (130) de desserte une limite de seuil représentant le nombre de commutations qu'une station mobile (140) peut effectuer dans un intervalle prédéterminé. Dans lse cas où une station mobile (140) à déplacement rapide dépasse le nombre de commutations fixé, on écarte une sélection de cellules suivant la méthode de localisation de cellules hiérarchique. On applique, en revanche, une sélection de cellules suivant la méthode de localisation de cellules normale, afin de réduire le nombre de commutations suivantes effectuées par la station mobile (140) à déplacement rapide.
Patent EP-0932876-B1 (EP)
Inventor: MOHR MICHAEL
IPC: G06Q30/00
Filed: 1997-10-17
Granted: 2002-01-09
Abstract: The invention concerns a system and method for exchanging data in a network, in particular for automatically obtaining offers. The system comprises at least one central server (10) with a data memory which is provided with an input-connection unit and an output-connection unit, and at least one client and one data provider (20, 30) which are used to input and/or fetch data into and/or from the data memory of the central server (10) and can be connected to an input- and/or output-connection unit via a network (40) with terminals. The system is characterized in that the server comprises modules for automatically selecting data providers as a function of a client enquiry, and for automatically forwarding the enquiry to the data providers.
Patent EP-0836410-B1 (EP)
Inventor: LAFONTAINE DANIEL M
IPC: A61B5/0215
Filed: 1997-03-06
Granted: 2003-11-05
Abstract: A guide wire that is capable of sensing the phasic pressure at the distal end of the guide wire. The guide wire has a central lumen which provides a non-compliant fluid path from the distal end of the guide wire to a pressure transducer at the proximal end of the guide wire.
Patent EP-0850252-B1 (EP)
Inventor: LAWRENCE DANIEL A
IPC: A61K38/00
Filed: 1997-04-11
Granted: 2005-06-08
Abstract: Mutants of the human PAI-1 protein are described which are inhibitors of neutrophil elastase or are inhibitors of vitronectin (Vn)-dependent cell migration. These mutants preferably comprise one or two amino acid substitutions in the reactive center loop of PAI-1, particularly at positions 331 and 346 of the mature protein. These mutants are notable in being resistant to inactivation by elastase, having high affinity for Vn, or both properties. These mutant proteins as pharmaceutical compositions are used to inhibit elastase in a subject, thereby treating a number of disorders associated with elastase activity, most notably emphysema, ARDS, inflammatory lung injury and cystic fibrosis. The mutants which interact with Vn are used to inhibit cell migration in a subject, thereby treating diseases or conditions associated with undesired cell migration and proliferation, particularly of smooth muscle cells. Such conditions include atherosclerosis, post angioplasty restenosis, fibrosis associated with chronic inflammation or chemotherapy, tumor invasion and metastasis and conditions in which angiogenesis is pathogenic. Also disclosed are peptides of such mutant proteins, mutant-specific antibodies, nucleic acid molecules, particularly DNA, encoding the mutant protein and host cells transformed by such nucleic acids.
Patent EP-0927043-B1 (EP)
Inventor: CHERSKEY BRUCE
IPC: A61K39/00
Filed: 1997-04-07
Granted: 2006-12-13
Abstract: The present invention relates to a method for implanting producer cells into the mammalian brain. The producer cells are engineered with a retroviral based recombinant vector encoding a tumorcidal factor or susceptibility factor that confers on tumor cells sensitivity to chemotherapeutic or radiotherapeutic agents. Prior to transplantation into the mammalian brain, the producer cells are first cultured in vitro on a support matrix to increase the long-term viability of the transplanted cells and to provide long-term functional benefit.
Patent EP-0929310-B1 (EP)
Inventor: FENG LILI
IPC: A61K38/22
Filed: 1997-06-04
Granted: 2007-08-01
Abstract: Compositions comprising OB-R agonists and methods of treatment for conditions such as systemic inflammatory response syndrome are provided. One suitable OB-R agonist ligand is recombinant human OB protein, also known as leptin. Also provided are methods and compositions for the treatment of obesity and OB resistance. Assay methods and kits relating to these conditions are also included.
Patent EP-0925507-B1 (EP)
Inventor: NI WEI-CHAO
IPC: G01N35/10
Filed: 1997-09-08
Granted: 2002-07-24
Abstract: A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A composition comprising a non-denaturing surfactant and a reagent for use in the assay is provided. The probe is contacted with the composition during the assay such that hydrophobic material is substantially prevented from coating the probe on the automated analyzer. Compositions for preventing such probe coating are also described. Methods and compositions comprising a non-denaturing surfactant for enhancing the stability of reagents used in an assay are also described.
Patent EP-0964652-B1 (EP)
Inventor: INGLE FRANK
IPC: A61N1/40
Filed: 1997-11-05
Granted: 2004-08-18
Abstract: Devices, systems, and method for treating urinary incontinence generally relying on energy delivered to a patient's pelvic support tissue to selectively contract or shrink at least a portion of that pelvic support tissue so as to reposition the bladder. The energy will preferably be applied to the endopelvic fascia and/or an arcus tendineus fascia pelvis. A variety of devices and methods are provided for applying gentle resistive heating of these and other tissues to cause them to contract without imposing significant injury on the surrounding tissue structures. By applying sufficient energy over a predetermined time, the tissue can be raised to a temperature which results in contraction without significant necrosis or other tissue damage. By selectively contracting the support tissues, the bladder neck, sphincter, and other components of the urinary tract responsible for the control of urinary flow can be reconfigured or supported in a manner which reduces urinary leakage.
Patent EP-0954358-B1 (EP)
Inventor: MAGGIOLO MARCO
IPC: A63C17/06
Filed: 1997-12-01
Granted: 2002-11-13
Abstract: Skates with in-line wheels, each comprising a supporting structure (10) to which supports (14, 15) are connected for a plurality of wheels (16-19), wherein at least one of the central wheels (17, 18) is coupled to the supporting structure so that it can change the level of its rotation axis.
Patent EP-0946879-B1 (EP)
Inventor: BUECHLER KENNETH F
IPC: G01N33/68
Filed: 1997-12-15
Granted: 2005-06-08
Abstract: A method for the diagnosis of heart muscle damage comprising: 
using an immunoassay system to determine the amount of cardiac troponin I in a blood, plasma, or serum sample supspected of containing troponin from damaged heart muscle, said system comprising (a) formation of an antibody conjugate comprising an antibody coupled to a signal generating element, said antibody being capable of specifically binding to cardiac specific regions of the troponin I complexes and of unbound troponin I, (b) formation of a reaction mixture comprising said whole blood, plasma or serum sample incubated with said antibody conjugate, (c) application of said reaction mixture to a surface to which is bound at least one capture antibody capable of specifically binding to cardiac specific regions of troponin I, said capture antibody binding said antibody conjugate, whereby the immobilized conjugate produces a detectable signal upon formation of sandwich complexes, and (d) relating of the detectable signal to the amount of cardiac troponin I present in said sample, wherein said antibody is insensitive with respect to the free troponin I and cardiac troponin I complexed with troponin C and troponin T, i.e. yields an assay response for said free and complexed forms of cardiac troponin I that is the same within a factor of 2; and 
relating the amount of cardiac troponin I present in said sample to the occurrence or non-occurrence of heart muscle damage.
Patent EP-0855261-B1 (EP)
Inventor: GELLERT JOBST ULRICH
IPC: B29C45/73
Filed: 1998-01-22
Granted: 2004-09-08
Abstract: Injection molding hot runner apparatus having a cooled mold core (74) with an elongated body portion (76) with a front portion or head (72). A cooling tube (90) extends centrally in body portion (76) of the mold core. A cooling fluid circuit (112) extends from the open front end (92) of the cooling tube (90) outwardly through a number of spaced radial bores (100). Each radial bore (100) connects to an L-shaped duct (106) leading back to a cylindrical space (98) around the cooling tube (90). <IMAGE>
Patent EP-0850596-B1 (EP)
Inventor: HEMPEL DIETRICH DR MED
IPC: A61B17/14
Filed: 1993-12-17
Granted: 2000-03-01
Abstract: A surgical saw comprising an elongate saw shaft (10), a sector-shaped saw blade (11) secured to the shaft (10) and having a number of outer teeth, holding means including a handle (12), the saw shaft (10) rotatably mounted in the holding means, a second shaft (14) also rotatably mounted in the holding means, and mounted coaxially and exteriorly with respect to the saw shaft (10), both shafts (10,14) being rotatable with respect to the other and lockable in a predetermined angular position in the holding means, an eccentric member (15) mounted to a free end of second shaft (14) close to the saw blade (11), and the saw blade (11) and the eccentric member (15) extending radially outwardly a predetermined selected distance so that they can be inserted into a hollow bone, wherein the holding means comprise a pair of members comprising a base plate (13) and an adjusting plate (17) rotatably mounted an operatively connected with respect to each other, the adjusting plate (17) being fixed to the saw shaft (10) and the base plate (13) being fixed to the second shaft, and wherein the adjusting plate (17) is mounted to said handle (12), and releasable means to adjust the adjusting plate (17) relative to the base plate (13), wherein the saw shaft (10) and second shaft (14) are guided in a gripping tube (21) wherein the gripping tube (21) has a free end and includes a stop (26) at the free end, wherein the gripping tube comprises a first and a second tube portion (24,23) movable with respect to each other, the first tube portion (24) being fixedly secured to the holding means and the second tube (23) portion including the stop (26), wherein the first and the second tube portions are threaded to each other and can be locked in relative positions with respect to each other by means of a locking nut provided on the first tube portion to engage a front end of the second tube portion. <IMAGE>
Patent EP-0910994-B1 (EP)
Inventor: BONNASSIEUX GILLES
IPC: A61B19/00
Filed: 1998-10-09
Granted: 2003-07-23
Abstract: The continuous multilayer fabric (100) is formed by the simultaneous unwinding of a hydrophilic cotton gauze (10) and a nonwoven (20) from their rolls (1,2). At least one automatic tension control (3) acts on the unwinding actions. The materials (10,20) pass together through a powered takeoff station (4) before reaching the workstations (5,8,17,18) where they are bonded together into the separate disposable fabric sections. Continuous nonwoven ribbons or bias bindings (6) are unwound (9) and placed along the longitudinal edges of the multilayer fabric, and are folded over the edges to be welded (17) in place by ultrasonic welding seams. At a cutting station (18), the fabric is cut laterally into separate lengths (200), and any dust is extracted by suction. The cut fabric is taken off by a drive (16), on a line at right angles to the cutting line, and the cut edges are sealed by folded ribbons or bias bindings with ultrasonic welding together with a thread in at least one of the four edges which gives radio detection. Before the material is cut into lengths (200), and preferably before the edge bindings are laid, a number of longitudinal ultrasonic welds are formed along the material at intervals across the fabric width. The tension of the cotton gauze material is set by the powered takeoff and a bobbin roll (1) brake. The tension of the nonwoven material is set after it has been unwound from its roll (2) by an automatic tension control, between the wound roll and the takeoff with a friction grip on the nonwoven by the flanking cotton gauze layers. An automatic tension control is applied to the multilayer material between the ribbon laying station (8) and/or the welding station and the cutting station.
Patent EP-0972024-B1 (EP)
Title: Suppresseur tumoral ts10q23.3
Inventor: STECK PETER
IPC: C12N15/12
Filed: 1998-01-08
Granted: 2011-02-23
Abstract: On a effectué une série d'études sur une région spécifique du chromosome 10 (10q23.3) contenant un gène suppresseur de tumeur impliqué dans les gliomes et dans un bon nombre de cancers chez l'homme. On a identifié un gène dans cette région, la région codante correspondante du gène représentant une nouvelle protéine 47 kD. Un domaine de cette protéine présente une correspondance parfaite avec le domaine catalytique conservé des protéines tyrosines phosphatases indiquant un rôle fonctionnel possible dans des cas de phosphorylation. Des analyses de séquences ont mis en évidence que le nombre a d'exons du gène a été supprimé dans les lignées cellulaires utilisées pour définir la région 10q23.3, ce qui a amené à classifier ce gène comme suppresseur tumoral. D'autres analyses ont mis en évidence la présence d'un nombre de mutations dans le gène, dans les cellules cancéreuses des gliomes et de la prostate. L'invention concerne également des procédés de diagnostic et de traitement des cancers en rapport avec ce suppresseur tumoral appelé TS10q23.3.