baber/WOPTO huggingface dataset:
Patent CA-2476571-A1 (CA)
Inventor: AICHINGER GERALD
IPC: A61K39/00
Filed: 2003-02-27
Abstract: Cette invention concerne une méthode permettant d'isoler des ligands présentant une capacité de liaison à la molécule MHC/HLA ou un complexe composé de ce ligand et de cette molécule MHC/HLA, laquelle méthode comprend les étapes suivantes consistant : à utiliser un ensemble de ligands, lequel ensemble comprend des ligands qui se lient à la molécule MHC/HLA ainsi que des ligands qui ne se lient pas à cette molécule MHC/HLA ; à mettre en contact cette molécule MHC/HLA avec l'ensemble de ligands, après quoi un ligand présentant une capacité de liaison à la molécule MHC/HLA se lie à cette molécule MHC/HLA, ce qui permet d'obtenir un complexe composé du ligand et de la molécule MHC/HLA ; à détecter et éventuellement à séparer ce complexe des ligands qui ne se lient pas à cette molécule MHC/HLA ; et éventuellement à isoler et à caractériser le ligand de ce complexe. Cette invention concerne également une méthode permettant d'isoler des épitopes de lymphocyte T qui présentent une capacité de liaison à la molécule MHC/HLA.
Patent CA-2477604-A1 (CA)
Title: Modulation of protein methylation and phosphoprotein phosphate
Inventor: STOCK JEFFRY
IPC: A61K38/46
Filed: 2003-03-13
Abstract: The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates as well to the agents and to compositions comprising the agents. In a particular aspect in this regard the invention relates to agents that alter PP2A methylation and that thereby affect phosphorylation of phosphoproteins that play an important role in health or disease, such as the tau protein which is implicated in the etiology of Alzheimer's Disease. The invention further relates to diagnostic methods bas ed on protein methylation levels, to compositions comprising agents for affecti ng methylation of proteins and for controlling the phosphate complement of phosphoproteins. Additionally, the invention relates to methods for administering the agents and compositions to affect methylation of proteins physiologically and to modulate the phosphate complement of phosphoproteins. Examples in this regard include agents and compositions that affect physiological activity of PP2A and alter the phosphate complement of phosphoproteins that are altered in disease.
Patent CA-2478176-A1 (CA)
Inventor: BROMLEY WILLIAM
IPC: G06Q10/08
Filed: 2003-03-03
Abstract: A system and method for monitoring, configuring, programming and/or diagnosing operation of at least one vehicle includes an on-board unit disposed on the vehicle to send and receive data corresponding to at least one vehicle operating characteristic, a plurality of modular applications, each application having an associated function that processes the data corresponding to said at least one vehicle operating characteristic obtained via the on-board unit, and an interface that allows selection among the plurality of modular applications to create a customized system.
Patent CA-2478582-A1 (CA)
Title: Portable x-ray device
Inventor: MILES DALE A
IPC: H05G1/02
Filed: 1996-12-13
Abstract: A portable and preferably hand-held X-ray generator (10) for use in intraoral and other X-ray applications, and a new process of dental image acquisition which utilizes a novel receptor holder (24) physically linked to the lightweight, portable generator (10). and a unique, articulating arm (104) and cradle (108) which allows one generator (10) to be used in multiple operatories. The system's generator has a reduced X-ray output and much smaller focal spot area than conventional dental X-ray generators which reduces the X-ray output and the overall patient X-ray burden. The smaller focal spot also allows to improved resolution is the final image.
Patent CA-2480638-A1 (CA)
Title: Substituted benzazoles and use thereof as raf kinase inhibitors
Inventor: RAMURTHY SAVITHRI
IPC: C07D453/02
Filed: 2003-03-31
Abstract: New substituted benz-azole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
Patent CA-2481148-A1 (CA)
Title: Cartridge holder for automated reprocessor
Inventor: COULOMBE SERGE
IPC: A61B1/12
Filed: 2003-04-04
Abstract: A cartridge holder (30) for an automated endoscope reprocessor (10) is mounted on a movable rack (14). As the rack is wheeled into the chamber, a connector (164) on the cartridge holder (30) automatically makes a fluid connection with a connection port (158) within the chamber (12). The cartridge holder includes a base (42) and a lid (44), which is pivotally connected to the base by a hinge (110). A cartridge (40) holding a dose of a disinfectant concentrate or reagents is positioned in a well (50) defined by the base and the lid closed.  Water flows through the cartridge holder via a fluid passageway (A) defined in part by the lid and in part by the hinge. The water mixes with the concentrate or reagents and the resulting disinfectant solution passes out of a lower end (205) of the cartridge into the well. The solution flows upwardly, around the cartridge, through an annular space (232) between the cartridge and the well, disinfecting the well in the process. The solution exits the cartridge through a plurality of bores (80) at an upper end of the base.
Patent CA-2481525-A1 (CA)
Inventor: KELLY PAUL ANDREW
IPC: A43C15/16
Filed: 2003-04-09
Abstract: An outsole for an article of studded footwear in which said outsole (1) includes receptacles (2) for specifically-oriented studs (5). The outsole (1 ) also includes traction elements (7) formed integrally with the outsole (1). The studs (5) and traction elements (7) being so constructed and arranged to interact in use of the footwear. The traction elements (7) are designed to complement the spike configuration of the stud (5).
Patent CA-2486093-A1 (CA)
Title: System and method for offering geocentric-based incentives and executing a commercial transaction via a wireless device
Inventor: POSTREL RICHARD
IPC: G06Q30/02
Filed: 2003-03-26
Abstract: A system and method of obtaining geocentric or location-specific information over a cellular telephone connection. A user enters an information access code (24) into his remote device (1), which has cell phone capability (2) and a GPS  receiver (6), which sends an incentive request (18) (including the access code (24), a user identification code (20), and GPS location data (22)) to an information server (16) via the cellular network (12). The information to server (16) uses the request to retrieve an incentive record as a function of the access code (24) and the GPS location data (22), and then transmits the incentive record back to the remote device (1) via the cellular telephone network (12). The remote device provides the incentive record to the user via a user interface (4) such as a display screen. The incentive record will have information related to a merchant offering the incentive for a product of interest to the user that is located in a vicinity of the remote device, since the information server is aware of the location of the user due to the GPS  data it receives.
Patent CA-2486841-A1 (CA)
Inventor: DAROLIA RAMGOPAL
IPC: C23C4/08
Filed: 2004-11-04
Abstract: According to an embodiment of the invention, a method for repairing a coated high pressure turbine blade, which has been exposed to engine operation, to restore coated airfoil contour dimensions of the blade, and improve upon the prior bond coat is disclosed. The method comprises providing an engine run high pressure turbine blade including a base metal substrate made of a nickel-based alloy and having thereon a thermal barrier coating system. The thermal barrier coating system comprises a diffusion bond coat on the base metal substrate and a top ceramic thermal barrier coating comprising a yttria stabilized zirconia material. The top ceramic thermal barrier coating has a nominal thickness t. The method further comprises removing the thermal barrier coating system, wherein a portion of the base metal substrate also is removed, and determining the thickness of the base metal substrate removed.  The portion of the base metal substrate removed has a thickness, .DELTA.t. The method also comprises applying a .beta. phase NiAl overlay coating to the substrate, and determining the difference in thickness, .DELTA.x, between the .beta. phase NiAl overlay coating and the previously removed bond coat. The method further comprises reapplying the top ceramic thermal barrier coating to a nominal thickness of t+.DELTA.t-.DELTA.x, wherein .DELTA.t compensates for the portion of removed base metal substrate. Advantageously, the coated airfoil contour dimensions of the high pressure turbine blade are restored to about the coated dimensions preceding the engine run.
Patent CA-2487506-A1 (CA)
Title: Multi-stage pre-transfer substrate heating assembly
Inventor: KRUCINSKI MARTIN
IPC: B41J29/00
Filed: 2004-11-15
Abstract: An ink image producing machine has (a) imaging devices, including at least one ink jet print head and an image receiving station for producing an ink image on a heated substrate; (b) a substrate handling assembly including holding devices for holding supplies of substrates, and transport feeding devices for transporting and feeding substrates in a substrate direction towards the image receiving station; (c) a first substrate heating assembly located upstream of the image receiving station for initially heating each substrate being fed and transported from the holding devices; and (d) a second substrate heating assembly located downstream of the first substrate heating assembly and upstream of said image receiving station, relative to the substrate feeding direction, for controllably re-heating each substrate, initially heated by the first substrate heating assembly, to a desired ink image receiving temperature.
Patent CA-2487727-A1 (CA)
Inventor: CHAPMAN KEVIN
IPC: C07D233/54
Filed: 2003-05-23
Abstract: L'invention concerne des composés de formule générale (I), et une méthode de traitement de l'anthrax ou d'inhibition du facteur létal par administration d'une composition contenant un composé de formule générale (I) et d'un excipient pharmaceutiquement acceptable. L'invention concerne en outre l'utilisation desdits composés afin de traiter d'autres états associés à une infection par l'anthrax.
Patent CA-2489080-A1 (CA)
Inventor: MALHOTRA DEEPAK
IPC: F16B7/00
Filed: 2004-12-14
Abstract: A mast assembly for a satellite dish assembly includes a mast member having an aperture therethrough, and a level mounted interior of the mast member but visible from outside the mast member through the aperture in the mast member.
Patent CA-2489648-A1 (CA)
Title: Chemical process
Inventor: BOLOOR AMOGH
IPC: C07D231/56
Filed: 2003-06-17
Abstract: A process for the preparation of pyrimidine derivatives, which are useful as VEGFR2 inhibitors is described herein. The described invention also includes pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
Patent CA-2489763-A1 (CA)
Inventor: AIROLDI ANNALISA
IPC: A61P13/10
Filed: 2003-06-04
Abstract: The present invention relates to novel crystalline, water-soluble salts of the 2S,3S enantiomer of reboxetine (Z-[-.alpha.-(2-ethoxy-phenoxy)-benzyl]-morpholine), which are the fumarate and succinate salts thereof, to a process for their preparation, to their utility in therapy and to pharmaceutical compositions containing them.
Patent CA-2490325-A1 (CA)
Inventor: GONDA IGOR
IPC: A61P25/16
Filed: 2003-06-24
Abstract: The present invention provides a pharmaceutical composition for transdermal delivery comprising: one or more physiologically active agents; one or more dermal penetration enhancers; a pharmaceutically acceptable carrier comprising a volatile solvent; and a hydrofluorocarbon propellent; wherein the carrier and penetration enhancers combine to provide a single-phase solution of the one or more physiologically active agents.
Patent CA-2493529-A1 (CA)
Inventor: GAUVIN FABRICE
IPC: F01N13/02
Filed: 2003-07-30
Abstract: Disclosed is a method according to which a first oxygen sensor (21) is disposed on the exhaust pipe upstream from a nitrogen oxide trap (18), and the development of a meaningful signal that is representative of the signal (3, 4) supplied by said sensor is monitored. A substantial increase (34, 44) of said meaningful signal, which is obtained following a variation (31, 41) resulting from the motor being switched from running on a lean mixture to running on a rich mixture, from a first plate (32, 42) having an essentially constant level is used as an indicator for controlling the end of the purge process. The invention applies to diesel engines.
Patent CA-2494647-A1 (CA)
Title: Modular prosthesis kits
Inventor: CZAJKOWSKI JOHN D
IPC: A61F2/46
Filed: 2005-01-20
Abstract: Modular prosthesis kits and systems are disclosed. The kit includes a plurality of stems (12) having a bore (30) therein and a plurality of necks (20) having a tapered distal end (22) adapted to taper lock in the bore (18) of one of the stems (12). Each neck (20) includes a stem registration element (32) on the distal end of the neck (20), and each stem (12) includes a neck registration element (30) in an end portion of the bore (18). The stem registration elements (32) of certain necks (20) and the neck registration elements (30) of certain stems (12) are configured to prevent certain necks (20) from taper locking with certain stems (12) in at least one position, and the stem registration elements (32) of certain necks (20) and the neck registration elements (30) of certain stems (12) cooperate to permit taper locking of certain necks (20) with certain stems (12).
Patent CA-2494882-A1 (CA)
Inventor: YAN SUEN CHING
IPC: A42B1/06
Filed: 2003-08-25
Abstract: A cap having a versatile sunglass retainer and retainer enable retention of glasses of all sorts having temples and end pieces that can be passed into and held between the cap-retainer enclosure. The retention patch may be generally square and flat in shape and sized appropriately for use with a cap, such as a baseball cap, The top edge of the patch may be indented to give it a convex shape at the bottom of which a fifth fastener may be set in conjunction with the other four fasteners at the corners of the patch. Five openings are then defined between the fasteners through which the end piece of the glasses may pass. Engagement of the end pieces- and temples of the glasses by the cap-patch enclosure serves to retain the glasses on the head of the wearer when the cap is worn. The retention patches are generally used in pairs so that both end pieces and temples of a pair of glasses may be engaged and better retained on 10 the head of the wearer. Frictional engagement of the glasses via its frame and the engagement with the cap-patch enclosure serves to retain the glasses on the head of the wearer while the configuration and location of the patch and its fasteners serve to provide versatile means for glasses retention that enable many different configurations of glasses retention to be achieved.
Patent CA-2496135-A1 (CA)
Title: Method and apparatus for improving fault isolation
Inventor: STONE JOHN F
IPC: G06Q10/04
Filed: 2003-08-14
Abstract: A method for improving fault isolation for failure modes in complex systems, and a software program embodying the method or a corresponding method together with a computer based aircraft diagnostic system using such software is described. The method includes: capturing a set of symptoms that is consistent with a failure mode of the complex system; identifying a set of repairs for the complex system that are consistent with the set of symptoms; ranking, when the set of repairs includes more than one repair, the repairs in a sequence that will minimize an average cost to repair the complex system, the sequence including a historical component and reflecting the effectiveness of available test results to resolve each the repairs; determining possible tests that are consistent with the failure mode; and ranking the possible tests according to there respective net improvement in the average cost to repair the complex system, then, preferably, selecting a test and obtaining a test result and repeating above processes until only one repair remains.
Patent CA-2497767-A1 (CA)
Inventor: LACKEY JOHN WILLIAM
IPC: C07K7/00
Filed: 2003-09-26
Abstract: La présente invention concerne des conjugués comprenant un polymère auquel sont liées au moins deux molécules d'un peptide de synthèse dérivé de VIH gp41, des procédés pour utiliser ces conjugués afin d'inhiber la transmission du VIH à une cellule cible, par addition d'une quantité efficace pour inhiber une infection de la cellule par le virus, ainsi que des procédés pour produire lesdits conjugués par liaison fonctionnelle de chaque molécule de peptide de synthèse au polymère, via une fonctionnalité réactive.
Patent CA-2498590-A1 (CA)
Inventor: CHO JAEWON J W C
IPC: B60C23/00
Filed: 2005-02-16
Abstract: The air pressures of the tires of all vehicles are fixed at proper value. So, when the pressure is low, the mileage is degraded, but the traveling distance on sudden braking is reduced. On the contrary, when the pressure is high, the mileage is improved at the cost of an aggravated braking distance. Accordingly, we are supposed to inject a proper amount of air on the compromise of good mileage and short braking distance, and the pressure is maintained invariantly. The wheel of this invention makes it possible that tires have high pressure an traveling and low one on sudden braking, consequently mileage improvement and shortened traveling distance on sudden braking are realized at the same time.
Patent CA-2503551-A1 (CA)
Inventor: HILTON JOHN ALLEN
IPC: G01L5/16
Filed: 2003-10-28
Abstract: A three-dimensional force and torque converter unit for measuring an external force or torque applied to the unit and converting it into a signal, whereby the signal may be used to control a system or device incorporating the converter unit. The converter unit includes a controller formed with four spaced apart arms having six or more degrees of constraint. A force or torque may be applied to the tip portions of each of the arms via a gripping means.  Sensors are used to measure the deflection of the arms under an applied loading or torque and an output signal is generated.
Patent CA-2505578-A1 (CA)
Inventor: PONZIANI ROBERT LOUIS
IPC: G01K13/02
Filed: 2005-04-28
Abstract: A vane assembly (10) includes a vane (14) having a main axis, a first passageway (32) within the vane substantially parallel to the main axis, and a second passageway (34) aligned with the first passageway. The vane has a window portion (20) between the first passageway and the second passageway. The vane assembly also includes a sensor (12) inserted in the first passageway and having a portion (18) held in place in the second passageway, wherein a portion (16) of the sensor is exposed in the window portion of the vane.
Patent CA-2508389-A1 (CA)
Inventor: VETTER GREGORY J
IPC: E05D15/42
Filed: 2005-05-25
Abstract: A projection window operator providing horizontal displacement of a window relative to a vertical plane of the frame of the window. With at least one projection window operator installed on each of opposing sides of a window, the window can be actuated between a first closed position and second open position in which trickle ventilation is provided around the window. The projection window operators installed on a window can be interconnected for simultaneous actuation, or actuated individually, providing selective ventilation on either side.
Patent CA-2509135-A1 (CA)
Title: Production method of porous spherical particles of vinyl polymer
Inventor: MORI KENJIRO
IPC: C08F112/08
Filed: 2005-06-03
Abstract: The present invention provides a method of producing porous spherical particles, which includes suspension polymerization of a multifunctional monomer having two or more vinyl groups and a vinyl monomer having one vinyl group in an aqueous medium in the presence of a porogen and a distribution stabilizer, wherein the distribution stabilizer is polyvinyl alcohol having a saponification degree of 75 to 85 mol%. According to the method of the present invention, generation of particle agglomerates and large particles can be suppressed and porous spherical particles having a desired average particle size and a narrow particle size distribution can be conveniently produced.
Patent CA-2509538-A1 (CA)
Inventor: PIGEON JUNE V
IPC: A61B10/00
Filed: 2005-06-23
Abstract: The device "Urine Sample Funnel" for the female gender where at medical facilities requesting urine samples, in this invention the standard urine sample jar would be used. By screwing in the sample jar into the inside threaded discharge spout. IT is a one-hand usage and clear of wet urine fingers since the jar is attached to the funnel.
Patent CA-2510094-A1 (CA)
Inventor: MILLER WILLIAM M
IPC: F01L13/08
Filed: 2000-06-27
Abstract: A compression release mechanism for use in a single or multi-cylinder engine to make the engine easier to hand start. The assembly includes a compression release shaft disposed substantially within the camshaft. The compression release shaft is formed in at least two segments and can therefore be formed accurately, repeatedly and cost effectively using powder metal technology. Consequently, the weight of the flyweight member that is attached to the compression release shaft can be accurately controlled, thereby allowing the compression release mechanism to disengage at a precisely known rotational velocity of the camshaft. The compression release shaft may engage one or more valve actuation devices, which in turn force exhaust valves open during starting engine speeds. The compression release mechanism is conveniently contained within the housing by a housing wall bearing against the flyweight member and a cam bearing against an end of the compression release shaft. These bearing surfaces also hold the compression release shaft segments together.
Patent CA-2514219-A1 (CA)
Inventor: BRAMAN TODD L
IPC: F16F1/373
Filed: 2004-01-27
Abstract: An inertial sensor system has a base, an inertial sensor, and an isolator mount. The isolator mount fastens the inertial sensor to the base, and the isolator mount includes a bolt and first and second vibration absorbing members. The bolt is inserted through the inertial sensor and the base, the first vibration absorbing member is between the bolt and the inertial sensor, and the second vibration absorbing member is between the inertial sensor and the base. The isolator mount isolates the inertial sensor from vibration, shock, and/or acoustic noise transmitted from a host system through the base.