baber/WOPTO huggingface dataset:
Patent DK-175139-B1 (DK)
Inventor: GOLDIE ROBERT STRONECH
IPC: A61K9/52
Filed: 1987-10-30
Granted: 2004-06-14
Abstract: A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of hydromorphone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form when measured by the USP Paddle Method at 100rpm in 900ml aqueous buffer (pH between 1.6 and 7.2) at 37 DEG C is between 12.5% and 42.5% (by weight) hydromorphone released after 1 hour, between 25% and 55% (by weight) hydromorphone released after 2 hours, between 45% and 75% (by weight) hydromorphone released after 4 hours and between 55% and 85% (by weight) hydromorphone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of hydromorphone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.
Patent DK-174837-B1 (DK)
Inventor: LEMOINE YVES
IPC: C12P/
Filed: 1986-12-30
Granted: 2003-12-15
Abstract: Functional block of DNA enabling to prepare hirudine from yeast, characterized in that it comprises at least: - the gene of hirudine or one of its variants (gene H); - A DNA sequence (Str) comprising the signals providing for the transcription of the gene H by the yeast.
Patent FI-102355-B1 (FI)
Inventor: GREENFIELD ROBERT S
IPC: A61K47/48
Filed: 1989-02-08
Granted: 1998-11-30
Abstract: The present invention relates to novel immunoconjugates, methods for their production, pharmaceutical compositions and method for delivering cytotoxic anthracyclines to a selected population of cells desired to be eliminated. More particularly, the invention relates to immunoconjugates comprised of an antibody reactive with a selected cell population, having a number of anthracycline molecules linked to its structure. Each anthracycline molecule, having a keto group at the C-13 position, is conjugated to the antibody via a linker arm and is bound to that linker arm via an acid-sensitive acylhydrazone bond at the 13-keto position of the anthracycline. The immunoconjugates and methods of the invention are useful in antibody-mediated drug delivery systems for the preferential killing of a selected cell population in the treatment of diseases such as cancers and other tumors, non-cytocidal viral or other pathogenic infections, and autoimmune disorders.
Patent FI-101841-B1 (FI)
Inventor: RAUSCH HARTMUTH
IPC: H02K5/10
Filed: 1989-10-05
Granted: 1998-08-31
Abstract: The invention relates to a cooled electric motor having a stator, a rotor and end shields, as well as a fan for higher types of protection than IP 23. The characteristic of the invention is a detachable, sealing cover (20) for protecting the electrical parts, in particular the winding overhangs, in the end chambers of the motor between the end face of the stator lamination and the end shield. <IMAGE>
Patent IE-49175-B1 (IE)
Title: Cephalosporin antibiotics
IPC: C07D501/36
Filed: 1979-08-08
Abstract: Cephalosporin antibiotics of general formula: (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group, and Y(+) represents a C-linked 5- or 6-membered heterocyclic ring containing at least one C1-4 alkyl-substituted quaternary nitrogen atom, which ring may also contain one or more sulphur atoms) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms. A particular antibiotic compound of formula (I) possessing excellent antibacterial activity against strains of Pseudomonas organisms, as well as other valuable therapeutic properties, is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxycyclobut-1-oxyimino )acetamido]-3-[(1-methylpyridinium-4-yl)-thiomethyl]ceph-3-em-4-carbox ylate. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
Patent IE-39516-B1 (IE)
Title: Corticoid-containing inhalant preparations
IPC: A61K9/00
Filed: 1974-06-20
Abstract: 1479488 Inhalant compositions SCHERING AG 24 June 1974 [23 June 1973] 27902/74 Heading A5B Inhalant compositions suitable for treatment of allergic disorders of the respiratory tract comprise a corticoid of formula:- in which -B-A- represents -CH 2 -CH 2 -, -CH=CH-, or -CCl=CH-; X is H, F or CH 3 ; Y is H, F or Cl; Z is -CH 3 -, -C(OH)H-, -CFH-, -CClH-, or -C(O)-; R 1 is H or CH 3 ; R 2 is H, or R 1 and R 2 together are an isopropylidene-dioxy group: and R 3 is a C 1 -C 12 hydrocarbon residue, in admixture or conjunction with a suitable carrier. The compositions may be in a capsule and contain dextran, mannitol, glucose or lactose as carrier. Antibodies such as chloramphenicol tetracyclines, penicillins cephalosporins. lincomycins, erythromycins and rifamycins, may also be present.
[GB1479488A]
Patent IE-35758-B1 (IE)
Title: Carboxymethyl cellulose salts and their production
IPC: C08B11/12
Filed: 1971-10-19
Abstract: Alkali metal salts of carboxymethyl cellulose are prepared by producing and then etherifying alkali cellulose under conditions selected to result in a molar excess of neutralized acidic etherifying reagent to moles of unreacted neutralizing reagent together with extended etherifying time and temperature conditions, i.e., about 3 to about 24 hours at about 60 DEG C. to about 80 DEG C. to yield substantially insoluble acidic products, which products are white in color, have a reflectance brightness of about 70 to about 80, have a normally soluble degree of substitution range of about 0.4 to 1.2 and are absorptive and retentive of up to about 70 times their weight of aqueous solutions.
[US3678031A]
Patent IE-62969-B1 (IE)
Title: Delivery systems for the controlled administration of LHRH analogs
Inventor: SANDERS LYNDA M
IPC: A61K9/22
Filed: 1988-05-06
Abstract: An implantable polymeric delivery system for the controlled and continuous administration of an LHRH analog which comprises a silicone elastomer matrix in which is dispersed about 30 to about 42 weight percent of water-soluble particulate phase containing an LHRH analog or a pharmaceutically acceptable salt thereof.
Patent IE-59144-B1 (IE)
Title: Heterocyclic compounds as fungicides
IPC: C07D233/90
Filed: 1986-05-23
Abstract: Compounds having the general formula (I): …… and stereoisomers thereof, wherein A is the group =CW- or a nitrogen atom, B is the group =CX- or a nitrogen atom, D is the group =CY- or a nitrogen atom, and E is the group =CZ- or a nitrogen atom, wherein W, X, Y and Z, which may be the same or different, are hydrogen or halogen atoms, or nitro, nitrile, the group …… or any of the following, optionally substituted groups, namely alkyl, cycloalkyl, cyclalkylalkyl, alkenyl, alkynyl, aryl, aralkyl, arylazo, alkoxy, heterocyclyloxy, aryloxy, amino, acylamino, or the groups CO2R<3>, CONR<4>R<5>, COR<6> or S(O)nR<7> (where n = 0, 1 or 2) or CR<8> = NR<9>; and wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8>, which may be the same or different, are hydrogen ( but R<1> and R<2> are not hydrogen) atoms or alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, cycloalkyl groups or optionally substituted heteroaromatic, whilst R<9> may be alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkylalkyl; V can be either oxygen or sulphur.
Patent IE-49055-B1 (IE)
Title: Non-propellant,duration spray dispenser with positive shut off valve
IPC: B05B11/02
Filed: 1979-08-08
Abstract: An aerosol dispenser which achieves duration spray without using chemical propellants. The non-propellant operated spray dispenser (D) includes structure (10, 19) for mechanically pressurizing the material to be dispensed by pumping the material into an expansible bulb (11) for storage under pressure for subsequent dispensing of the material, and a snap-acting positive shut-off valve (16) is provided to terminate discharge of the material when pressure falls below a predetermined minimum.
Patent IE-53345-B1 (IE)
Title: Process for the production of ketoamines
IPC: A61K31/12
Filed: 1982-06-15
Abstract: This invention relates to a process for the production of ketoamines corresponding to the formula:  in which R2 represents hydrogen or a C1-C6 alkyl group, R3 represents hydrogen or a hydroxy group, and R1 represents an adamantyl radical or a saturated or mono-unsaturated C3-C16 cycloalkyl radical, which C3-C16 cycloalkyl radical may also be substituted by a C1-C4 alkyl group or a halogen atom, and salts thereof by reducing an unsaturated compound corresponding to the formula:
Patent IE-45398-B1 (IE)
Title: Web feed apparatus
IPC: B65H20/04
Filed: 1977-08-05
Abstract: The present invention relates to a machine feed device working on a sheet of material at a standstill. This device is characterized in that it comprises means 16, 17, 18, 19, 21, 23, 24, 25 for converting the continuous movement of the sheet 2 to its entry into the machine in an intermittent movement synchronized with that of the moving part of the machine so that the web is advanced while the two parts are separated from each other and it is kept at a standstill during the work done on the web, that is, when the two parts are applied to each other. 
This device is applicable to flat cutting presses.
Patent IE-55423-B1 (IE)
Title: Extrusion of metal
IPC: B21C25/02
Filed: 1984-07-06
Abstract: A die unit for extrusion apparatus, especially Conform apparatus, comprises a die 10 and die holder 11. The die is supported in the holder but is surrounded over at least a substantial part of its length by a sleeve 12 extending from the working face between the die and the die holder and made of a metal soft compared with the die and the die holder. Suitable metals are mild steel and the metal being extruded. Round wire can be formed.
[EP0131426A2]
Patent IE-56689-B1 (IE)
Title: A method for production of combustion turbine blade having a single crystal portion
IPC: F01D5/28
Filed: 1985-08-02
Abstract: This is a process of fabricating turbine blades for combustion turbines. It is an improvement to the type of process where a mold containing molten metal is cooled in a controlled fashion such that solidification occurs slow enough to allow single crystal growth beginning at the airfoil end. In the improved process solidification is monitored and magnetic mixing of the remaining molten metal is started at approximately the beginning of solidification of said root section and at approximately the same time the rate of cooling of said blade is increased to a rate faster than at which single crystal growth occurs. Grain boundary strengthener (preferably carbon) can be added at approximately the same time mixing is begun. A blade is produced with a single crystal airfoil section and a fine grained root section and without a substantially inhomogeneous portion at the interface between the airfoil and root sections.
[US4637448A]
Patent IE-41680-B1 (IE)
Title: Substituted 2-alkoxyxarbonylamino-benzimidazolyl-5(6)-phenyl ethers and -ketones and process for preparing them
IPC: C07D295/092
Filed: 1975-09-09
Abstract: of the disclosure: New anthelmintically active basically substituted 2-carb-alkexy-amino-benzimidasolyl-5(6)-phenyl ethers and -ketones are disclosed as well as a process for preparing them. The new compounds are chemotherapeutica having a particular activity against ankylostomes, other helminths as well as liver fluke.
Patent IE-52193-B1 (IE)
Title: Predischarged nonaqueous cell
IPC: H01M4/50
Filed: 1980-11-04
Abstract: An electrochemical cell containing a non-aqueous electrolyte solvent a Li anode and a beta-MnO2 cathode, further contains small amounts of an additive material such as Li2, Na2S, K2S, MgS, CaS, Li2Se, Na2Se, K2Se, MgSe, CaSe, Li2T, Na2Te, K2Te, MgTe, or CaTe, which is admixed with the beta-MnO2 the additive causing partial self-discharge of the cathode of the cell with non- reactive products. The self-discharged partially deactivates substantially all of the active cathode surface as a reaction site thereby reducing the decomposition of the electrolyte solvent. Na, K, Mg, Ca and Al are alternative anode metals, and TiO2, SnO2, MoO3V2O5,CrO3, PbO and Fe2O3 may be used as cathodes.
Patent IE-66376-B1 (IE)
Title: 6-Alkylpyridazine derivatives method of preparation and pharmaceutical compositions in which they are present
Inventor: BRODIN ROGER
IPC: C07D409/04
Filed: 1991-07-29
Abstract: Pyridazine derivatives of formula: <IMAGE>  in which:   - Ar denotes an optionally mono- or disubstituted phenyl group, a pyridyl group or a thienyl group; - R3 denotes a C1-C5 straight or branched alkyl, a -CH2-C6H5 group or a -CH2-CH2-C6H5 group;   - R4 denotes the group <IMAGE> in which:   - X denotes a C1-C6 straight or branched alkylene - each of R5 and R6 independently denotes hydrogen or a C1-C4 alkyl, or, together with the nitrogen atom to which they are bonded, they form a heterocyclic ring chosen from pyrrolidine, morpholine or piperidine,  or else R4 denotes a group chosen from: <IMAGE> in which n is as defined above and R7 denotes H or a C1-C4 alkyl; <IMAGE> in which n is as defined above or <IMAGE> and their salts with inorganic or organic acids. Application: medications useful for the treatment of a cholinergic deficiency.
Patent IE-54933-B1 (IE)
Title: Television signal transmission
IPC: H04N7/01
Filed: 1983-11-28
Abstract: A television picture transmission system using conditional replenishment employs a scanning rate at the transmitter which differs (for asynchronous operation, slightly; or for operation between systems using different standards, considerably) from the scanning standard at the the receiver. The frame rate conversion is effected by the updating loops at the transmitter or receiver by, respectively, periodically stopping the coding loop for a field or frame so that no data is produced to produce a lower frame rate or periodically repeating a field or frame in the loop without adding any updating data so as to produce a higher frame rate. Resulting variations in data rate are accommodated by utilising the buffering inherent in conditional replenishment systems. The jerkiness of motion in the received picture resulting from stopping the loop or repeating a field or frame can be reduced by the use of temporal interpolation in the generation of the updating data to anticipate the stopping or repeating of a field or frame, whilst conversion of the number of lines per frame can be effected by spatial interpolation using a transversal filter.
Patent IE-59669-B1 (IE)
Title: Stressed polymeric device for controlled release of a substance to an ambient environment
IPC: A61L15/16
Filed: 1987-10-29
Abstract: A matrix device for controlled release of at least one active agent to an ambient environment, said matrix comprising an active agent - or agents - containing polymer which has been subjected to tensile stress. Included is a laminate device comprising at least one matrix as core sheet, said core sheet or sheets comprising the active agent or agents in a polymer matrix which has been subjected to stress and, in a further embodiment, a porosity enhancing agent in admixture with said agent; the core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. Also included are methods for making such a device.
Patent IE-55370-B1 (IE)
Title: Activation in a digital subscriber connection
IPC: H04L/
Filed: 1983-12-21
Abstract: Method and apparatus in a telecommunication system for activation of means from idling state to active state. The system includes a digital subscriber connection in which there is included a line terminal (LT) assigned to the station side of the system, a network terminal (NT) assigned to the subscriber installation and one or more subscriber terminal (ST). The line terminal is connected to a central clock pulse oscillator (master oscillator) (MCL) on the station side, the network terminal and subscriber terminals containing local clock pulse oscillators (slave oscillators) (CL). In activation from the subscriber side, a subscriber terminal (ST) sends an activation request (AR) in the form of a bit pattern sent in bursts to the network terminal (NT) via a TDM bus line ((BL). The network terminal sends the activation request (AR) to the line terminal (LT), in the form of a continuously sent, cyclic bit pattern. The line terminal sends an activation request to a station (EX), which then sends an activation order (AO) back to the line terminal, which sends an activation order (AO) in the form of a continuous bit pattern back again to the network terminal (NT). The network terminal then sends an activation order in the form of bit bursts to the subscriber terminal (ST). The subscriber terminal sends the activation order signal to the subscriber. In activation from the station side the activation order goes directly from the station without a preceding activation request from the subscriber.
[WO8402815A1]
Patent IE-59007-B1 (IE)
Title: Piperidine derivatives
IPC: C07D401/12
Filed: 1986-11-14
Abstract: The invention relates to compounds of formula <CHEM> wherein R represents hydrogen or fluorine and R<1> represents 3-pyridyl or 4-pyridyl or a salt thereof which compounds exhibit psychotropic activity and are useful as antidepressants.
Patent IE-54106-B1 (IE)
Title: Packaging of food salt
IPC: C01D3/26
Filed: 1982-12-22
Abstract: 1. Packaging of food salt, comprising a closed, airtight and watertight enclosure containing the salt in the state of particles, characterised in that the said particles are dispersed in a liquid saturated with sodium chloride.
Patent LU-100587-B1 (LU)
Title: A computer cloud terminal device
Inventor: LI XIAOLAN
IPC: H04L12/28
Filed: 2017-12-20
Granted: 2018-04-11
Abstract: The invention provides a computer cloud terminal device and belongs to the technical field of communication. The computer cloud terminal device comprises a case (1), a power interface (2), a left USB interface (3), a VGA interface (4), an LAN interface (5), a microphone jack (6), a headset jack (7), a right USB interface (8), an LAN indicator lamp (9), a power indicator lamp (10), a power source button (11), a fan, a heat-dissipating opening (12) and a standby battery. The computer cloud terminal device can be connected with a server to replace a computer host so that the function of the host can be achieved; the device is provided with the power indicator lamp, the LAN indicator lamp, the fan and a heat-dissipating hole, and the rotating speed of the fan can be automatically adjusted according to changes of internal temperatures and intelligently dissipate heat and cool a circuit mainboard so as to meet the requirement for continuous work in hot summer; in addition, the requirement of users can be met under the circumstance without power or the circumstance of powering off.
Patent LU-503171-B1 (LU)
Title: Terrain self-adaption unmanned weeding robot for hillside orchard
Inventor: LI QIANG
IPC: A01B39/16
Filed: 2022-11-16
Granted: 2023-11-30
Abstract: Disclosed is discloses a terrain self-adaption unmanned weeding robot for a hillside orchard, which comprises a crawler vehicle, a control system, mowing devices and an inter-plant telescopic mowing device. A chassis of the robot adopts a crawler-type chassis moving carrier, so that the robot has good passing ability in complex environments such as a mountain land; by adopting a technology of detecting fruit trees with cameras, the fruit trees in the orchard can be identified, so as to realize precise operation; and by using a laser radar, a map of the orchard can be constructed in real time, so as to realize automatic walking of the intelligent weeding robot for the orchard. Meanwhile, through combination with the advantages of the traditional rotary tillage type weeding machine, mowing mechanisms in the present invention further adopt the deep ploughing type mowing devices, so that roots of weeds can be effectively mowed, and the clearance rate of the weeds is effectively improved. The inter-plant telescopic mowing device adopts screw rods for transmission, to realize the left-and-right telescoping of the mowing devices, so as to realize inter-plant precise weeding.
Patent LU-504797-B1 (LU)
Title: Application of monitoring characteristics of infection, colonization and migration in host fruit tree tissues using GFP tagged strain of Erwinia amylovora
Inventor: LUO MING
IPC: G01N33/53
Filed: 2023-07-25
Granted: 2024-01-25
Abstract: The invention discloses an application of monitoring characteristics of infection, colonization and migration in host fruit tree tissues using GFP tagged strain of Erwinia amylovora, and relates to the technical field of plant pathology. According to the invention, GFP tagged strains of Erwinia amylovora are utilized, branches, leaves and root tissues of pear trees are inoculated by acupuncture, spraying and root irrigation methods respectively, diseased spots are measured by inoculated plant tissue materials, culture medium is selected for separation and cultivation, identification of fluorescent colonies is combined to quantitatively detect the number, migration time and rate of live bacteria infected and colonized by Erwinia amylovora in different host tissues. The spreading distribution, infection process of pathogenic bacteria in different tissues of the host were directly monitored by microscopic images. The invention has the advantages of convenient material acquisition, strong operability, simplicity, convenience, visualization, accurate result, short detection period, good repeatability.
Patent NO-301026-B1 (NO)
Inventor: KAUFMAN RICHARD ALLEN
IPC: C12Q1/26
Filed: 1990-08-27
Abstract: An improved enzymatic method for determining the concentration of an analyte in a sample body fluid including CO2 and ammonia, the novel reagent compositions used in this method, and diagnostic test kits useful for determining various analytes according to the method of the invention.
Patent NO-308427-B1 (NO)
Inventor: HENNEUSE HENRY
IPC: E21B44/00
Filed: 1992-05-14
Abstract: PCT No. PCT/FR91/00721 Sec. 371 Date Jul. 13, 1992 Sec. 102(e) Date Jul. 13, 1992 PCT Filed Sep. 12, 1991 PCT Pub. No. WO92/05337 PCT Pub. Date Apr. 2, 1992.Method for conducting an oil drilling operation, during which a drill-stem produces the rotation of a tool in an oil well. The method consists of the following steps: continually measuring the rotational speed of the upper end of the drill-stem; continuously measuring the torque applied to that end of the drill-stem; determining the torque applied to that end of the drill-stem; determining the torque variation; establishing the period of torque variation if the amplitude of the variation exceeds a predefined threshold; verifying the stability of this period; comparing the latter, if stable, with at least one predefined theoretical period; and reporting the results obtained to the user in order to control the drilling operation.
Patent NO-308855-B1 (NO)
Inventor: CHIODI FRANCESCA
IPC: C07K16/00
Filed: 1993-09-14
Abstract: A polypeptide linked to a solid matrix useful as a solid support of a diagnostic kit is disclosed. The polypeptide has the formula: X-Glu-Thr-Gly-Gln-Glu-Thr-Ala-Tyr-Phe-B-Leu-Lys-Leu-Ala-Gly-Arg-Trp-Pro-Val-Lys-Z, wherein B is Ile or Leu, X is a chain of from 1 to 20 amino acid residues or an amino-terminal group and Z is a chain of from 1 to 20 amino acid residues or a carboxy-terminal group. The polypeptide immunologically mimics HIV endonuclease.