baber/WOPTO huggingface dataset:
Patent CA-2376785-A1 (CA)
Title: Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors
Inventor: JANSSENS FRANS EDUARD
IPC: C07D417/14
Filed: 2000-06-20
Abstract: The present invention concerns compounds of formula (I), prodrugs, N-oxides,  addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a1=a2-a3=a4- represents a radical of formula  - CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; wherei n each hydrogen atom may optionally be substituted; Q is a radical of formulae  (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is C1 - 6alkanediyl; Y1 is a bivalent radical of formula -NR2- or -CH(NR2R4)-; X1 is  NR4, S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2-NR4 or NR4-CH2; X2 is a direct bond, CH2, C(=O), NR4, C1-4alkyl-NR4, NR4-C1-4alkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; an d whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b - 8), may optionally be replaced by R3; provided that when R3 is hydroxy or C1 - 6alkyloxy, then R3 cannot replace a hydrogen atom in the .alpha. position relative to a nitrogen atom; G is a direct bond or optionally substituted C1 - 10alkanediyl; R1 is an optionally substituted bicyclic heterocycle; R2 is hydrogen, formyl, C1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl,  homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R6)2 and optionally withanother substituent; R3 is hydrogen, hydroxy, C1-6alkyl, C1- 6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy, R4 is hydrogen, C1-6alkyl or arylC1-6alkyl; R5a, R5b, R5c and R5d are hydrogen or C1-6alkyl; or R5a and R5b, or R5c and R5d taken together from a bivalent radical of formula -(CH2) s- wherein S is 4 or 5; R6 is hydrogen, C1-4alkyl, formyl, hydroxyC1-6alkyl, C1 - 6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted pheny l; Het is pyridyl, pyrimidinyl, pyryzinyl, pyridazinyl; as respiratory syncytia l virus replication inhibitors; their preparation, compositions containing the m and their use as a medicine.
Patent CA-2380813-A1 (CA)
Inventor: DEO YASHWANT
IPC: A61K39/00
Filed: 2000-07-25
Abstract: L'invention concerne des anticorps monoclonaux humains isolés et des fragments de liaison à l'antigène de ces anticorps se liant spécifiquement à HER2/neu. L'invention concerne également des molécules bi- et multispécifiques, notamment des anticorps monoclonaux humains et des fragments de liaison à l'antigènes de ces anticorps se liant spécifiquement à HER2/neu. Ces anticorps humains peuvent être produits dans un animal transgénique, par exemple une souris transgénique, capable de produire de multiples isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et commutation isotypique. L'invention concerne enfin des compositions pharmaceutiques comprenant ces anticorps humains, des animaux transgéniques et des hybridomes produisant ces anticorps humains, ainsi que des méthodes thérapeutiques et diagnostiques basées sur l'utilisation desdits anticorps humains.
Patent CA-2380818-A1 (CA)
Title: Dispensing bottle closure
Inventor: MARKEY KEVIN J
IPC: B67D7/02
Filed: 2000-08-02
Abstract: A closure member (10) for use with a bottle (12) wherein the bottle (12) is threadably connected to a filling head of an apparatus for diluting and dispensing a concentrated chemical product.  The closure member (10) is frictionally fitted into the neck of the bottle and has threads (34) to interconnect the bottle to the filling head. In a preferred manner, the frictional fit between the closure member and the bottle neck is provided by flexible forger members (32, 38) extending from the closure member and a rib member (40) extending from the neck of the bottle. In another preferred manner, the closure member includes a core section (18) for housing a valve body (22).
Patent CA-2386105-A1 (CA)
Title: Method for reconstructing a non-human mammal embryo with foetal adult differentiated cells
Inventor: VIGNON XAVIER
IPC: C12N15/873
Filed: 2000-09-29
Abstract: The invention concerns the reconstruction in vitro of non-human mammal embryos by a method which consists in treating the nucleus of a somatic donor cell prior to its transfer into a receiver cytoplasm, said treatment comprising controlled proteolysis of non-histone proteins, and inducing an isomorphic swelling of said nucleus.
Patent CA-2386170-A1 (CA)
Inventor: RATCLIFFE OLIVER
IPC: C12N5/10
Filed: 2000-10-11
Abstract: Recombinant polynucleotides and methods for modifying the flowering time of a plant are provided. Plants transformed with the recombinant polynucleotides may have flowering times that are accelerated, delayed or induced under specific conditions. Additionally, transformed plants may have altered vernalization requirements.
Patent CA-2388590-A1 (CA)
Title: Method and apparatus for converting between logical and physical memory space in a raid system
Inventor: PERRY DAVID D
IPC: G06F3/06
Filed: 2000-10-27
Abstract: A method for converting between logical and physical memory space which adap ts to different RAID types and configurations in a modular form. In particular,  a module containing a standard set of conversion algorithms (78) is used for a ll conversions. The standard set of conversion or translation algorithms operat e on a pseudo representation of a RAID array that has all redundant components  removed. For each RAID type and configuration, the standard algorithms can b e used unchanged if a method is provided to convert the real RAID array representation into the pseudo version and back again. This simplifies both the programming and the debugging. This also makes the software more modular  and more easily upgradeable.
Patent CA-2388823-A1 (CA)
Inventor: KEANE DAVID
IPC: A61F2/82
Filed: 2000-09-11
Abstract: A cardiac ablation catheter (100) includes a coil-like ablating element (102) that is deployed from an elongate, flexible sheath (104).  The ablating element (102), while in the deployed position, has a shape with at least one revolution oriented in a plane that is orthogonal to a longitudinal axis (108) of the sheath. The catheter system (100) is well-suited to ablate a circumferential region of tissue about a pulmonary vein or the posterior wall of the left atrium proximate the pulmonary vein os. The treated tissue region electrically isolates the atria from the pulmonary vein.
Patent CA-2388828-A1 (CA)
Title: Topical anesthetic formulation
Inventor: WEPFER SCOTT
IPC: A61K31/167
Filed: 2000-10-23
Abstract: The topical anesthetic formulation of the present invention is typically a solution that preferably includes lidocaine, USP as the active anesthetic ingredient with benzyl alcohol and isopropyl alcohol. This invention deals with problems commonly associated with topical application of local anesthetics such as: slow onset of action; need for occlusion; messiness of creams, ointments or gels; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the anesthetic and  thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicit y.
Patent CA-2389077-A1 (CA)
Title: Polyamide composition
Inventor: OKA HIDEAKI
IPC: C08K3/16
Filed: 2002-06-05
Abstract: Provided is a polyamide composition comprising 100 parts by weight of (A) a semiaromatic polyamide having dicarboxylic acid units mainly composed of aromatic dicarboxylic acid units and diamine units mainly composed of aliphatic diamine units having 4 to 14 carbon atoms and containing not more than 15 µeq/g of terminal amino groups; and 0.01 to 5 parts by weight of (B) a copper compound. The polyamide compositions of the present invention have excellent heat aging characteristics, as well as excellent mechanical characteristics, low-water-absorption property and dimensional stability. The polyamide compositions of the present invention can be used as molding materials for industrial materials or household goods and are, especially, suited for a various article, which is used at a high temperature, such as engine room parts of an automobile.
Patent CA-2389975-A1 (CA)
Inventor: APPEL PETER WILLEM
IPC: C11D3/06
Filed: 2000-11-24
Abstract: A multi-region detergent tablet of compressed particulate composition is provided comprising a detergent active compound, a detergency builder, particles which contain sodium tripolyphosphate with a content of the Phase I form which is more than 40% by weight of the sodium tripolyphosphate in the said particles, at least one salt other than said sodium tripolyphosphate which can be further hydrated and optionally other detergent ingredients, where in one or more of the regions which contains the particles which conta in sodium tripolyphosphate there is less than 10% by weight of that region of further hydratable salts, and there is at least one region containing at lea st 10% by weight of that region of further hydratable salts.
Patent CA-2390889-A1 (CA)
Title: Method and apparatus for selective injection or flow control with through-tubing operation capacity
Inventor: PRINGLE RONALD E
IPC: E21B43/12
Filed: 2002-06-18
Abstract: An in-line flow control device for a well chokes flow through a conduit while allowing access therethrough.
Patent CA-2391004-A1 (CA)
Inventor: BAKER BRENDA F
IPC: C12Q1/6813
Filed: 2000-11-10
Abstract: La présente invention concerne des méthodes et des procédés permettant de quantifier la quantité d'oligonucléotides présents dans un échantillon de fluide et/ou extrait corporel. Les méthodes et procédés de l'invention permettent la détection et/ou la localisation d'oligonucléotides à des fins thérapeutiques et/ou pharmacocynétiques grâce à un test à sensibilité élevée qui exploite la capacité d'enzymes à reconnaître des conformations et structures d'acide nucléique spécifiques.
Patent CA-2393458-A1 (CA)
Title: Preparation of concrete accelerator
Inventor: HOFMANN THOMAS
IPC: C04B22/06
Filed: 2000-12-01
Abstract: An alkali-free accelerator for sprayed concrete is prepared by dissolving aluminium sulphate and amorphous alu-minium hydroxide in water which optionally contains one amine, and optionally adding at least one stabiliser, selected from hydrox-ycarboxylic acids and phosphoric acids and non-alkaline salts thereof, and at least one defoaming agent.
Patent CA-2393559-A1 (CA)
Title: Methods for the syntheses of alfentanil, sufentanil and remifentanil
Inventor: KILLGORE J KENDALL
IPC: C07D211/66
Filed: 2000-12-04
Abstract: Synthetic pathways are disclosed for synthesizing derivatives or analogs of fentanyl. Specifically set out are pathways for synthesizing alfentanil, sufentanil and remifentanil. The disclosed methods require fewer steps and produce a greater yield of product than methods reported in the prior art. The pathways to all these compounds begin with a common pathway of condensing a piperidone with a primary amine so as to form a 4-amino-4-carboxyamino-piperidine, wherein N of said piperidone is a-N-COO-(CH2)n CH3, alkylating an N of said primary amine which was condensed with said piperidone thereby producing an N-alkyl-anilide, and hydrolyzing said -COO-(CH2)n CH3 group of said 4-amino-4-carboxyamino-piperidine following the condensation reaction so as to form a piperidine hydrolysis product. This product can then be converted to remifentanil in a 4 step reaction. Also, this hydrolysis product can be treated with a hydride to yield a 4-hydroxymethyl-piperidine which can be converted to alfentanil in 3 further steps, to sufentanil in 3 more steps, or to a variety of remifentanil analogs in two steps.
Patent CA-2393739-A1 (CA)
Inventor: MULLEN KLAUS
IPC: G01N33/543
Filed: 2002-07-17
Abstract: The invention relates to a chemical sensor comprising a sensor film formed of a nanoparticle network in which the nanoparticles are interlinked by functionalized dendrimer molecules. The dendrimers support an efficient uptake of analyte molecules by the film material and therefore enable a high sensitivity of the sensor. In addition, the chemical nature of the dendrimers strongly determines the chemical selectivity of the sensor device. By cross-linking the components of the sensitive material the sensor displays a good mechanical stability.
Patent CA-2394754-A1 (CA)
Title: Hospital bed
Inventor: VISCA MATTHEW
IPC: A61H23/02
Filed: 2000-12-29
Abstract: Published without an
Patent CA-2397119-A1 (CA)
Inventor: WIRES DONALD LOUIS
IPC: A61F13/49
Filed: 2001-01-31
Abstract: A flexible manufacturing system including at least one module, a operational unit mounted to said at least one module and a local controller operatively connected to the operational unit. The local controller is adapted to control the operational unit. The at least one module and the local controller together are capable of operating in a standalone operation or of integration into a flexible manufacturing system. The local controller is further adapted to receive a reference signal from the flexible manufacturing system and to synchronize the operational unit to the flexible manufacturing system when the at least one module is connected to the flexible manufacturing line.
Patent CA-2399819-A1 (CA)
Inventor: KAULARTZ DAGMAR
IPC: C07C213/08
Filed: 2001-01-18
Abstract: The invention relates to a process for the enzymatic cleavage of racemates of aminomethyl-aryl-cyclohexanol derivatives.
Patent CA-2405287-A1 (CA)
Title: Hand-held electronic device with a keyboard optimized for use with the thumbs
Inventor: MAJOR HARRY R
IPC: G06K11/06
Filed: 1999-06-28
Abstract: A hand-held electronic device with a keyboard, thumbwheel, display and associated software is optimized for use of the device with the thumbs. A plurality of features to optimize efficient use of the limited keyboard space and encourage the use of the device by thumb-based data entry through the thumbwheel and/or through a combination of minimal number of keystrokes.  Features include international character scrolling, autopunctuation, undo, character substitution and phrase substitution. In addition, the keys on the device keyboard are optimally shaped and configured for thumb-based input.
Patent CA-2406717-A1 (CA)
Inventor: HOANG KHOI
IPC: H04N7/173
Filed: 2001-05-31
Abstract: The present invention teaches methods and systems for providing full digital services in a non client specific manner such as VOD, digital broadcast, as well as a universal set-top-box (STB) capable of handling this variety of digital services. A plurality of hardware architectures and complimentary data transmission methods identifying the distinct services through an electronic program guide enable such transmission. The universal STB of the present invention is capable of distinguishing the different services based on information received in the electronic program guide, and is capable of processing non client specific data via a dat manger (408). The present invention further provides viewing options such as multiple broadcasts and virtual time-shifting features including pausing, recording, and freeze framing a broadcast. Still further, this variety of digital services can be provided via a u ni-directional communication link.
Patent CA-2406802-A1 (CA)
Title: Aqueous enzymatic denture adhesives
Inventor: KANG HARJINDER
IPC: A61K6/884
Filed: 2002-10-07
Abstract: Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobial denture adhesive compositions are stabilized against enzymatic action prior to oral application of the adhesive by incorporating a thickener into the adhesive formulation so as to provide the forrmulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the adhesive package. An illustrative, thickened, enzymatic adhesive with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with a mixture of polyacrylic acid and polyvinylpyrrolidone in an amount to provide the adhesive with a viscosity of at least about 300,000 centipoises.
Patent CA-2407417-A1 (CA)
Title: Sound-transmitting apparatus
Inventor: KEAR STEPHEN
IPC: H04R1/10
Filed: 2001-04-17
Abstract: Apparatus (10) for transmitting sound between a user and a communications device such as a mobile telephone comprises a non-electrical ear piece (13) connected via a tube (12) to an adaptor (22) which can be electrically connected to the mobile phone. A further tube (14) has a voice entry end (14b) and is coupled at the other end (14a) to the adaptor. Sound travels up tube (12) from the phone to the user and down tube (14) from the user to the phone.
Patent CA-2407761-A1 (CA)
Title: Assembly for transferring fluid from a flexible container
Inventor: RUDZENA WILLIAM L
IPC: A61M3/02
Filed: 2001-06-08
Abstract: An assembly suitable for transferring fluid from a flexible container to a wound irrigation site. The assembly comprises a connector having an end capable of being joined to a flexible container containing a fluid, a nozzle end, and a valve between the end capable of being joined to the flexible container and the nozzle end. The nozzle end of the connector is preferably joined to a splashback shield. The end of the connector that is capable of being joined to the flexible container preferably comprises a spike that serves to pierce a seal on the flexible container. In the preferred embodiments, the valve is actuated by pressure, which is typically supplied by a medical practitioner. The pressure actuatable valve is preferably a ball valve. The splashback shield is preferably substantially hemispherical in shape. The splashback shield preferably contains at least one passageway, preferably a plurality of passageways, for allowing spent irrigation fluid to drain from the wound site.
Patent CA-2409870-A1 (CA)
Title: Corrosion resistant aluminium alloy
Inventor: DAALAND OLE
IPC: C22C21/02
Filed: 2001-05-21
Abstract: An aluminium-based alloy consisting of 0,05-1,00 % by weight of iron, 0,05-0,60 % by weight of silicon, less than 0,50 % by weight of copper, up to 1,20 % by weight of manganese, 0,02 to 0,20 % by weight of zirconium, up to 0,50 %  by weight of chromium, 0,02 to 1,00 % by weight of zinc, 0,02 to 0,20 % by weight of titanium, 0,02 to 0,20 % by weight of vanadium, up to 2,00 % by weight of magnesium, up to 0,10 % by weight of antimony, up to 0,02 % by weight of incidental impurities and the balance aluminium, the total amount of Ti plus Cr plus V being less than 0.3 % by weight and the amount of V being lower than the amount of Cr, said aluminium-based alloy exhibiting high corrosion resistance and high extrudability.
Patent CA-2412717-A1 (CA)
Title: Evaporative edge cooling of a fuel cell
Inventor: ZIMMERMAN JOERG
IPC: H01M8/04
Filed: 2002-11-25
Abstract: A method and apparatus for cooling an electrochemical fuel cell which comprises coolant channels extending along the edge of the fuel cell, adjacent to the active area whereby the fuel cell is cooled by evaporating a liquid coolant in the coolant channels. The coolant may then be condensed and recirculated through the coolant channels. Efficient cooling of the fuel cell may be enhanced by reducing the boiling point of the coolant by reducing the pressure across the coolant channels.
Patent CA-2412857-A1 (CA)
Title: Hiv integrase inhibitors
Inventor: WALKER MICHAEL A
IPC: C07D317/40
Filed: 2001-06-18
Abstract: The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the formula (Ia) wherein R1 is C1-C4 alkyl, carbocyclic radical, heterocyclic radical, aryl-C1-C2 alkylene, aryloxy-C1-C2 alkylene, alkoxy-CC(O)-, wherein R1 is optionally substituted from 1-3 times with halo, C1-C2 alkyl or C1-C2 alkoxy, or R1 is H;  R2 is H or C1-C4 alkyl; R3 is H, C1-C4 alkyl or phenyl-C0-C2 alkylene which is optionally substituted with 1-3 R5; R4a is carbocylic radical, heterocyclic radical, aryloxy, aryl-C1-C4 alkylene, aryl-cyclopropylene, aryl-NHC(O)-, wherein R4a is optionally substituted with 1-3 R5; and wherein each R5 is independently selected from H, halo, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 haloalkyl, C1-C4 alkoxy, R6-phenyl, R6-phenoxy, R6-benzyl, R6-benzyloxy, NH2C(O)-, alkyl-NHC(O)-, wherein R6 is H, halo; Z is a bond or a substituted or unsubstituted C1-C4 alkylene group; and B2 is formula (a), (b), or (c).
Patent CA-2415664-A1 (CA)
Inventor: MERLINI CORNELIUS
IPC: G06F19/00
Filed: 2001-07-10
Abstract: L'invention porte sur un procédé (figure 1) visant à réduire les erreurs des consommateurs dans la sélection d'un médicament destiné à traiter des états asymptomatiques ou chroniques et encourager l'utilisation à long terme d'un médicament approprié. La première étape de ce procédé consiste à guider progressivement le consommateur pour lui faire comprendre les informations portées sur l'étiquette du médicament, ce qui amène le consommateur, par le biais de certains critères, à déterminer si l'utilisation du médicament est appropriée. Une autre étape consiste à inciter le consommateur à lire le feuillet d'instructions inclus dans l'emballage ou regarder un support visuel tel qu'une cassette vidéo lui expliquant les informations portées sur l'étiquette. Une autre étape consiste à encourager le consommateur à utiliser le médicament sur une longue durée, l'inciter à appeler un service téléphonique gratuit afin de parler avec un spécialiste connaissant bien le produit. Pour les consommateurs autorisés à prendre le médicament, le spécialiste donne des conseils sur l'utilisation correcte du produit. Pour des consommateurs non autorisés, le spécialiste conseille au consommateur de discuter du produit et de son état avec un médecin et lui facilite le remboursement intégral du produit.
Patent CA-2417900-A1 (CA)
Inventor: ELLIOT GARY S
IPC: A61K39/395
Filed: 2001-07-24
Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provide d for are methods for the treatment, diagnosis, amelioration, or prevention of  diseases with C3b/C4b CR-like polypeptides.
Patent CA-2421400-A1 (CA)
Title: Skating training aid
Inventor: DUMONT MARC
IPC: A63B21/06
Filed: 2003-03-04
Abstract: A skating training aid consisting of a base plate that slides on the ice - or rolls on any other less slippery surface - and is made of a series of telescoping adjustable rods and the said device can also accept weight plates to adjust the level of strength required to push it while practicing skating movements.
Patent CA-2423706-A1 (CA)
Inventor: HANN KEITH
IPC: B60J1/20
Filed: 2003-03-26
Abstract: A self-mounting automobile window screen for placing between opposing parts of an automobile window frame is disclosed. The window-mounting screen comprises of flexible mesh screen attached to a rubber base and foam rope at the remaining edges. The screen is made to fit a specific model of vehicle and installed into the window channels manually. This provides a resilient but sturdy means to temporarily create a barrier and seal around the window opening when the vehicle is stationary. The screen can be anchored and detached repeatedly without causing damage to the vehicle or the screen. The screen can be conveniently stored in a nylon bag when not in use.
Patent CA-2431533-A1 (CA)
Inventor: RENDINA DAVID D
IPC: B01J27/047
Filed: 2003-06-07
Abstract: Catalysts and composite materials comprised of catalytically active materials intercalated with alkali metals and/or optionally coated on alkali metals or combinations of alkali and alkali earth metals are disclosed. Also disclosed are methods for enhancing reactions between hydrogen and organic materials by reacting said catalysts with solvents where such reactions generate a portion of the hydrogen and heat necessary to cause the desired reaction between an organic material and hydrogen and also act to fracture said catalytically active material into higher surface area particles with enhanced catalytic ability. Said catalysts may be dispersed in immiscible aprotic solvents to enhance transportation and safety considerations prior to use.