baber/WOPTO huggingface dataset:
Patent AT-E162225-T1 (AT)
Inventor: FARR SPENCER B
IPC: G01N33/00
Filed: 1993-07-06
Granted: 1998-01-15
Abstract: This invention provides methods and diagnostic kits for determining the toxicity of a compound. The methods and diagnostic kits of this invention employ a plurality of E. coli hosts, each of which have been transformed with a DNA sequence encoding a unique stress promoter fused to a gene which encodes an assayable product. Each of these stress promoters is induced by exposure to a different type of cellular stress. The stress promoters utilized in this invention, in toto, comprises those which respond to redoxo stress, DNA stress, protein stress, energy stress and pH stress. The methods and diagnostic kits of this invention may be employed to characterize and quantify the toxicity of a compound, as well as to identify the cellular mechanism of its toxic action. The methods disclosed herein represent a more humane and economical alternative to the live animal testing currently employed to test the toxicity of new chemicals. Moreover, the methods of this invention, yield information concerning the action of a compound on a subcellular level. This information may be utilized to design antitoxins to compounds found to be toxic and in active drug design.
Patent AT-E145817-T1 (AT)
Inventor: TIMMER CHRISTIENA JANNIE
IPC: A61K8/21
Filed: 1993-09-10
Granted: 1996-12-15
Abstract: The present invention is related to a mouth-care product comprising an effective amount of at least one lantibiotic and an effective amount of at least one compound yielding fluoride ions.
Patent AT-E194830-T1 (AT)
Inventor: HAIGH W GEOFFREY
IPC: A61K9/48
Filed: 1993-10-27
Granted: 2000-08-15
Abstract: Compositions of high-purity natural beta-carotene and of the 9-cis isomer of beta-carotene are provided, as are methods for the production of these compositions from plant matter, conveniently algae such as Dunaliella species. Typically, the compositions contain at least about 5% 9-cis beta-carotene and less than or equal to 40% of all-trans-beta-carotene, and in some cases may contain 75% 9-cis beta-carotene or higher. The compositions are suitable for administration to humans or other animals, particularly for oral delivery, in a variety of formulations and dosages as pharmaceutical agents or as dietary supplements.
Patent AT-E149880-T1 (AT)
Inventor: SCHRENK W JUERGEN
IPC: G01N33/48
Filed: 1993-11-02
Granted: 1997-03-15
Abstract: A sample collection container having inner and outer chambers. The container may be fitted with upper and lower stoppers to provide a vacuum within the container. The device is adapted for the collection of a fluid, such as blood, in the inner chamber. The blood then passes from the inner chamber to the outer chamber upon releasing the vacuum. A concentrate of fluid components of blood, cellular debris, and contaminating microorganisms, if present, may be left in the inner chamber, and be removed subsequently from the inner chamber for testing for the presence of contaminating microorganisms.
Patent AT-E169625-T1 (AT)
Inventor: SHIMADA JUNICHI
IPC: C07D473/04
Filed: 1994-04-07
Granted: 1998-08-15
Abstract: There is provided a novel xanthine Compound(I) <CHEM> wherein R<1> and R<2> are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is <CHEM> wherein R<3> and R<4> are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R<3> and R<4> are hydrogen, at least one of R<1> and R<2> is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof. The xanthine compound has adenosine A1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.
Patent AT-E167271-T1 (AT)
Inventor: BOURKEL ARSENE
IPC: F16K17/06
Filed: 1994-07-07
Granted: 1998-06-15
Abstract: A pilot stage for a pressure limiting valve comprises an axially displaceable valve piston (110) which delimits a valve chamber (141) axially at one end and forms a valve seat (140) therein for a closing cone (104). In a pressure chamber (164), the valve piston (110) forms an actuating surface which is considerably larger than the free cross-section of the valve seat (140). By subjecting this pressure chamber (164) to pressure, a large hydrostatic force is exerted on the valve piston (110), this force being opposed to the closing force of the pressure-setting spring (106). A housing stop (130) defines a first axial end position of the valve piston (110) in the direction of this hydrostatic force. The pilot stage has improved properties both in manually adjustable and in proportional pressure limiting valves. <IMAGE>
Patent AT-E161597-T1 (AT)
Inventor: THEURER JOSEF
IPC: E01B27/00
Filed: 1994-05-10
Granted: 1998-01-15
Abstract: The installation is for underground renovation of a ballast bed of a rail track (9) and has a machine frame (4) supported on a rail under-carriage (8) and having a track lifting device together with a height-adjustable clearance device for removal of ballast from beneath the track. A conveyor belt is provided for conveyance of level silicate sand. The machine frame supported on the track by a rail under-carriage is connected with clearance devices (5) spaced apart in the machine longitudinal direction and height-adjustable independently of one another. The clearance device arranged at the front in the work direction is used for removal of the upper layers of the ballast bed and the successive rear clearance device is formed for the raising of the residual ballast and of an adjoining earth level. <IMAGE>
Patent AT-E182804-T1 (AT)
Inventor: MORRIS EARL D
IPC: A63F3/08
Filed: 1993-11-30
Granted: 1999-08-15
Abstract: A gaming system (10) is provided including a central game processor (12), a plurality of master processing units (14) and a plurality of slave terminals (16) operable by players to play the game. The central game processor (12) communicates with the master processing units (14) and supplies the various games available to the system. The master processing units (14) store and administer the games as they are played on the slave terminals. A preferred game includes a fixed pool of game plays and a predetermined number of winning plays within each pool, Each player, through his or her slave terminal (16), can purchase plays in each fixed pool stored in the master processing unit (14) to which that unit is coupled. When a particular pool is exhausted, for example, through the purchase of all plays, the central game processor (12) provides another fixed pool of plays to that master processing unit to enable continuous play. <IMAGE>
Patent AT-E229072-T1 (AT)
Inventor: GAUGLER BEATRICE
IPC: A61K31/70
Filed: 1994-03-17
Granted: 2002-12-15
Abstract: The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-6. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
Patent AT-E166862-T1 (AT)
Inventor: KULMALA KARI
IPC: B01J23/02
Filed: 1994-06-20
Granted: 1998-06-15
Abstract: PCT No. PCT/FI94/00273 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Jun. 20, 1994 PCT Pub. No. WO95/00464 PCT Pub. Date Jan. 5, 1995The invention relates to a novel, technically simple but efficient and high-yield process for the preparation of 2-n-butyl-2-ethyl-1,3-propane diol from 2-ethyl hexanal and formaldehyde by using a basic alkali metal hydroxide or earth alkali metal hydroxide catalyst. In the process according to the invention, cationic or neutral phase transfer catalysts are additionally used for promoting the reaction. The correct choice of the sources of the initial material components is also essential. 2-n-butyl-2-ethyl-1,3-propane diol is used, for example, in the paint industry in the preparation of pulverous paints.
Patent AT-E177422-T1 (AT)
Inventor: CRIMMIN MICHAEL JOHN
IPC: A61K38/00
Filed: 1994-10-04
Granted: 1999-03-15
Abstract: PCT No. PCT/GB94/02145 Sec. 371 Date Oct. 28, 1996 Sec. 102(e) Date Oct. 28, 1996 PCT Filed Oct. 4, 1994 PCT Pub. No. WO95/09841 PCT Pub. Date Apr. 13, 1995A compound of formula (I):    <IMAGE>  (I)  wherein: R1 represents a (C1-C6)alkyl, phenyl, substituted phenyl, or heterocyclyl group; R2 represents a (C1-C6)alkyl group; R3 represents: (I) the side chain of arginine, lysine, tryptophan, histidine, serine, threonine, or cysteine, in which any polar amino, hydroxy, mercapto, guanidyl, imidazolyl or indolyl group is rendered substantially non-polar by substitution at the polar N-, O- or S-atom; or (ii) the side chain of aspartic or glutamic acid, in which side chain the carboxylic acid group is amidated; R4 represents hydrogen or a (C1-C6)alkyl or phenyl (C1-C6)alkyl group; R5 represents hydrogen or and n is 0, 1 or 2; or substituted phenyl groups; or a salt solvate or hydrate thereof. Compositions containing compound (I) and methods for treatment of diseases or conditions mediated by TNF or MMPs in mammals.
Patent AT-E161042-T1 (AT)
Inventor: SAITO HIROSHI
IPC: C12N5/0793
Filed: 1995-02-13
Granted: 1997-12-15
Abstract: Disclosed is a synthetic medium with PDGF, vitronectin, IL-1 beta and BSA added to Eagle's minimum essential medium or medium with transferrin, insulin, progesterone and putrescine further added thereto. When cultivating the postnatal central neurons using the inventive medium, there are effects such that good attachment to substrate, extension of neuritic processes and maintenance of survival are achieved, that more stable sure cultivation becomes possible as well over the astrocyte-conditioned medium used hitherto, and the like.
Patent AT-E193998-T1 (AT)
Inventor: TURUNEN ILKKA
IPC: B01J8/00
Filed: 1995-03-15
Granted: 2000-07-15
Abstract: The invention relates to a method for producing hydrogen peroxide by the anthraquinone process, by feeding into the top part of a fixed bed reactor (4) hydrogen (3) and a working solution (1), i.e. an anthraquinone derivative in an organic solvent, and by making these infed substances flow downwardly in the reactor, in order to catalytically hydrogenate the anthraquinone derivative owing to the influence of the catalyst bed (6) and by removing the hydrogenated working solution (9) from the reactor. According to the invention, there is used a fixed bed reactor provided with a stationary catalyst bed that has an open structure. The said working solution is fed into the top part of the reactor at a velocity so high that a separate gas space is not created at the top of the reactor, and that in the top part there is created a dense dispersion of the working solution and gas, and that in the reactor itself there is maintained a relatively high flow velocity, in order to make the said dense dispersion proceed deep down into the catalyst bed. The invention also relates to a fixed bed reactor used for realizing the process. <IMAGE>
Patent AT-E169157-T1 (AT)
Inventor: OKANIK PETER DIPL ING TU
IPC: A23L29/231
Filed: 1995-04-22
Granted: 1998-08-15
Abstract: The representation system is used for a number of stepping transformers connected in parallel to several collector rails, with respective voltage regulators. The concrete configuration data, e.g. the number of transformers and the number of collector rails, is held in a read-only memory with a microprocessor calculating all possible combinations of the transformer power switches and collector rail connections, to determine the corresponding circuit paths, represented by respective display elements. Only the display elements corresponding to the actual current path are activated, to provide the representation of the layout configuration on the monitor field. Pref. the display elements are provided by LED's.
Patent AT-E171857-T1 (AT)
Inventor: HARMS JUERGEN PROF DR
IPC: A61F2/00
Filed: 1995-12-21
Granted: 1998-10-15
Abstract: A space holder in particular for a vertebra or an intervertebral disk is provided. The space holder comprises a jacket (1) having apertures (9, 10) and a first and second edge (7, 8). The edge has circumferentially adjacent recesses (9, 10; 9', 10') each extending in direction towards the other edge and a stop provided at at least one of the edges spaced from the outer edge. In order to provide for an easy manufacture and operation of the space holder the stop is formed by a member (11, 13, 16, 22) having an outer contour corresponding to the inner contour of the jacket (1) and nose-like projections (15) for engaging the recesses (9, 10) are provided at those locations of the periphery of the stop which correspond to the recesses (9, 10; 9', 10').
Patent AT-E153989-T1 (AT)
Inventor: DE BRUYN RODOLPH
IPC: C04B18/10
Filed: 1995-02-06
Granted: 1997-06-15
Abstract: The invention relates to a method for processing slags of a waste incineration plant. In order to contribute toward a solution for the ecological problem of the slag mass, the invention provides the method for processing slags of a waste incineration plant, characterized in that slags are pre-treated and mixed in a concrete mixer together with cement and water to a concrete mass and that thin-walled concrete elements are manufactured from this concrete mass. The final removal by way of dumping slags is hereby avoided or reduced and these are employed usefully. <IMAGE>
Patent AT-E183796-T1 (AT)
Inventor: CHAUDRON JEAN-PAUL
IPC: E04B2/74
Filed: 1995-04-27
Granted: 1999-09-15
Abstract: The elongated element consists of retainers (19) to position the partitions (6,7) at the appropriate distance from one another, and spacers (26) between them, made from two rigid sub-structures (28) separated by flexible connectors (31) made from two supple and parallel components (33). The supple components have enlarged opposite edges which fit into anchoring grooves in the rigid sub-structures which are, for example dovetail-shaped in cross-section, and the edges can be made from a more rigid material than the central portions of the components. The outer sections of the retainers (19) are shaped to receive spring clips (23) on the inner faces of trim strips (24) covering the edges of adjacent panels or a gap between a panel and the floor. <IMAGE>
Patent AT-E194472-T1 (AT)
Inventor: GAUDEL JACQUES
IPC: A61B6/00
Filed: 1994-11-09
Granted: 2000-07-15
Abstract: A medical imaging apparatus for performing a radiological examination. The apparatus comprises a patient carrier (6) secured to a motor-driven articulated structure supporting X-ray equipment, particularly an X-ray generator and an X-ray image receiver. The articulated structure comprises a mounting (1) for holding said patient carrier (6), said mounting being rotatable about a horizontal axis 00' on a base (3). The mounting supports a telescoping column (5) which supports said patient carrier (6) and is translatably movable relative to said mounting. The mounting further supports a first portion (7) of a bent arm (7, 8), which portion (7) is pivotable about an axis (xx') extending in a vertical plane perpendicular to said rotation axis 00', and parallel to the longitudinal axis of the patient carrier (6). A second portion (8) of said bent arm (7, 8) carries said X-ray equipment (10, 11, 12) which is rotatable relative to said second portion (8) about a second rotational axis (yy') extending in a plane passing through the frame of said bent arm. The apparatus may be used as a radiological apparatus.
Patent AT-E282463-T1 (AT)
Inventor: EVANS BRIAN L
IPC: A63C17/02
Filed: 1994-12-22
Granted: 2004-12-15
Abstract: A vehicle truck for supporting a ground contacting device, and an independent-suspension turnable skate vehicle truck which supports a wheel or wheels or a runner or ski, and a boot having in-line wheels or tandem wheels is provided. The independent-suspension turnable skate vehicle truck has one or more deflecting beams attached to a wheel axle hanger and the opposite end attached to a skate vehicle mounting structure. The deflecting beam has at least one horizontal component and/or at least one vertical component. The vertical components resist vertical deflection of the wheel axle hangers to restrict upward and downward movement of the wheels or other ground contacting portions. The horizontal component controls most twisting motions controlling turning of the deflecting beam and wobble of the wheel. The truck and mounting surface are adaptable to permit changes to the number of wheels or ground contacting portions, the position of the wheels, and the thickness of the wheels.
Patent AT-E169301-T1 (AT)
Inventor: NORCINI GABRIELE
IPC: A61K31/66
Filed: 1995-06-16
Granted: 1998-08-15
Abstract: PCT No. PCT/EP95/02343 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed Jun. 16, 1995 PCT Pub. No. WO95/35302 PCT Pub. Date Dec. 28, 1995Compounds of formula (I),    <IMAGE>  (I)  wherein R is a biphenyl group optionally substituted, by one or more substituents, the same or different selected among halogen atoms, hydroxy groups, alkoxy, alkyl thioalkyl or alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety, C1-C3 alkyl groups containing one or more fluorine atoms, carboxy groups, nitro groups, amino or aminocarbonyl groups, acylamino groups, aminosulphonyl groups, momo- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety, mono- or di-alkylamino-carbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety; R1 is a hydrogen atom, a straight or branched C1-C6 alkyl group or an arylalkyl group having from 1 to 6 carbon atoms in the alkyl moiety wherein the aryl is a phenyl, a biphenyl, a napthyl or a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted with one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl, thioalkyl or alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety, C1-C3 alkyl groups containing one or more fluorine atoms, carboxy groups, nitro groups, amino or aminocarbonyl groups, acylamino groups, aminosulphonyl groups, mono- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety, mono- or di-alkylaminocarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety; R2 is a straight or branched C1-C6 alkyl group, optionally containing one or more fluorine atoms or one or more -NH- groups, an arylalkyl, an arylcarbonylaminoalkyl, an arylalkylcarbonylaminoalkyl or an arylaminocarbonylalkyl group having from 1 to 6 carbon atoms and optionally one or more -NH- groups in the alkyl moiety, the aryl being optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl, thioalkyl or alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety, C1-C3 alkyl groups containing one or more fluorine atoms, carboxy groups, nitro groups, amino or aminocarbonyl groups, acylamino groups, aminosulphonyl groups, mono-or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety, mono- or di-alkylaminocarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety; m is 0 or 1; X is a hydrogen or fluorine atom; the carbon atom marked with an asterisk is an asymmetric carbon atom; and their pharmaceutically acceptable salts, are described. The compounds of formula (I) are endowed with a mixed ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.
Patent AT-E173499-T1 (AT)
Inventor: BACKES THOMAS WHITNER
IPC: C11D3/04
Filed: 1995-07-12
Granted: 1998-12-15
Abstract: A phosphate-free, solid, block detergent containing an alkali metal salt of nitrilotriacetic acid, an acid, alkali metal containing hydroxides and silicates, and alkali metal containing carbonates and sulfates is taught. A process for producing the block detergent is also taught.
Patent AT-E265212-T1 (AT)
Inventor: SAITO KEN
IPC: A61K31/00
Filed: 1995-09-19
Granted: 2004-05-15
Abstract: An agent comprising a 4-aminoacyltetrahydrofuroÄ2,3-bÜquinoline derivative represented by formula (I): <CHEM> (wherein R<1> represents an alkyl group having 2 to 6 carbon atoms, etc.) or an acid addition salt or a hydrate or a solvent of them as an active ingredient. The compound has a protecting action against neuronal cell death and is useful as a therapeutic or prophylactic agent for cerebrovascular diseases, traumatic head injuries or postencephalitis.
Patent AT-E194988-T1 (AT)
Inventor: POWER PATRICIA L
IPC: C07D471/04
Filed: 1995-12-08
Granted: 2000-08-15
Abstract: Described herein are D4 receptor-selective compounds of the general formula:   <IMAGE>   wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH2, O, NH, S, C=O, CH-OH, CH-N(C1-4alkyl)2, C=CHCl, C=CHCN, N-C1-4alkyl, N-acetyl, SO2and SO; X2 - - - is selected from N=, CH2-, CH=, C(O)-, O-, and S-; n is 1 or 2; R1 is selected from H and an amino acid side chain; R2 is selected from H, OH, C1-9alkyl, C1-9alkoxy, and benzyloxy; and R3 is selected from H, OH, halo, cyano, C1-4alkyl, C1-4alkoxy, phenoxy, benzyloxy, =O, =S, C1-4alkylsulfonyl, C1-4alkylsulfonyl, C1-4alkylthio, amino, and aminocarbonyl; and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.
Patent AT-E175865-T1 (AT)
Inventor: KIYOMINE AKIRA
IPC: A61K8/46
Filed: 1996-02-23
Granted: 1999-02-15
Abstract: The object of the invention is a new isomer mixture of 3-hydroxybutyl monothioglycollate and 3-hydroxy-1-methyl propyl monothioglycollate in a weight proportion of about 1.5 : 1 to 4 : 1, preferably about 2 : 1 to about 3 : 1, comprising less than 5%, preferably less than 2% by wt., of 1,3-butanediol thioglycollate, and its use as the sole or main reducing agent in compositions for permanent waving of human hair. The compositions have reduced smell, good waving properties and an extremely low sensitizing potential on human skin.
Patent AT-E192992-T1 (AT)
Inventor: SCHUMACHER MARKUS
IPC: B60N2/48
Filed: 1996-07-30
Granted: 2000-06-15
Abstract: In a passenger service unit, particularly in a passenger cabin of an aircraft, comfort and service elements such as a reading lamp, a flight attendant call button, a loudspeaker, an air nozzle, an oxygen mask and generator, optical display elements, are integrated into a service column. Feeder lines between a main supply line and the passenger service columns are flexible to facilitate the mounting or placement of the columns as a complement to a passenger seat. The column is positioned in the lateral area of a seat to which the column is allocated.
Patent AT-E173031-T1 (AT)
Inventor: MIURA KENZO
IPC: F16J9/26
Filed: 1996-07-12
Granted: 1998-11-15
Abstract: Wear resisting steel, a sliding member for a cylinder in an internal combustion engine, and a ring spring consist of: carbon : equal to or less than 2.2 % by weight; silicon : equal to or less than 1.2 % by weight; manganese : equal to or more than 0.2 % by weight; chromium : equal to or less than 16 % by weight; phosphorus : equal to or less than 0.08 % by weight; sulfur : equal to or more than 0.15 % by weight; other compositions : equal to or less than 2.0 % by weiht; and the balance substantially consisting of iron. The surfaces thereof may be sulphurized. The steel has excellent resistance to wear and scuffing, provides high strength, great elongation, and high toughness, and also provides good machinability. <IMAGE>
Patent AT-E366802-T1 (AT)
Inventor: EVERETT PETER
IPC: C12N15/09
Filed: 1996-05-22
Granted: 2007-08-15
Abstract: A Namalwa cell line which is free of squirrel monkey retrovirus is useful for alpha-interferon production. The cell line can be used for the expression of recombinant polypeptides. It can be emplyed for packaging viruses for use in gene therapy.