Patent SG-11201906803W-A (SG)
Title: N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases
Inventor: DELHOMEL JEAN-FRANÇOIS
IPC: A61P31/00
Filed: 2018-01-29
Abstract: International Publication Date (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2018/138362 Al 0111111010 0111 °nolo 01110ll mil moiniou oimIE (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) 02 August 2018 (02.08.2018) WIPO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every CO7D 265/36 (2006.01) A61K 31/4725 (2006.01) kind of regional protection available): ARIPO (BW, GH, CO7D 215/48 (2006.01) A61K 31/498 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CO7D 241/52 (2006.01) A61K 31/454 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, CO7D 209/34 (2006.01) A61K 31/425 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7D 209/38 (2006.01) A61P 37/00 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 231/56 (2006.01) A61P 37/06 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 405/12 (2006.01) A61P 37/08 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 413/12 (2006.01) A61P 31/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7D 417/12 (2006.01) A61P 19/02 (2006.01) A61K 31/536 (2006.01) A61P 11/06 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: PCT/EP2018/052172 (22) International Filing Date: 29 January 2018 (29.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17305093.1 27 January 2017 (27.01.2017) EP 17178888.8 29 June 2017 (29.06.2017) EP (71) Applicant: GENFIT [FR/FR]; 885 avenue Eugene Avinee, 59120 Loos (FR). = (72) Inventors: DELHOMEL, Jean-Francois; 79 avenue du President JF Kennedy, 62000 ARRAS (FR). PERSPI- CACE, Enrico; 1 me Maurice SCHUMANN, 59133 PHALEMPIN (FR). MAJD, Zouher; 29 rue Nationale, 59320 ENNETIERES-EN-WEPPES (FR). PARROCHE, Peggy; 9 rue des Brigittines, 59800 LILLE (FR). WAL- CZAK, Robert; Residence Parc d'Isly, 13B rue Delezenne, 59000 LILLE (FR). (74) Agent: CABINET BECKER ET ASSOCIES; 25, me Louis le Grand, 75002 Paris (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. co (54) Title: N- f [2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYLI -2-(3-0X0-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7- YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AU- 00 TOIMMUNE DISEASES O (57) : The present invention provides e.g. N-f [2-(piperidin-l-yl)phenyl] (phenyl)methyll-2-(3-oxo-3,4-dihydro-2H-1,4-ben- zoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoim- C mune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.