Patent DE-102005062003-A1 (DE)
Title: Device for detection and/or quantitative measurement of a biological substance or biological molecule, comprises a target medium, a transport medium, a receptor medium assigned to the target medium, and a measuring unit
Inventor: BABEL WOLFGANG
IPC: G01N33/58
Filed: 2005-12-22
Abstract: The device for detection and/or quantitative measurement of a biological substance or biological molecule, comprises a target medium (3), a transport medium (2), a receptor medium (7) assigned to the target medium, and a measuring unit formed for applying in process- and automatic control. A supporting unit (6) is intended, in which the receptor medium is arranged. The supporting unit and the receptor medium are coordinated on each other. A regeneration unit is intended for the regeneration of the receptor medium. The device for detection and/or quantitative measurement of a biological substance or biological molecule, comprises a target medium (3), a transport medium (2), a receptor medium (7) assigned to the target medium, and a measuring unit formed for applying in process- and automatic control. A supporting unit (6) is intended, in which the receptor medium is arranged. The supporting unit and receptor medium are coordinated on each other. A regeneration unit is intended for the regeneration of the receptor medium. An exchange unit is intended for the exchange of the receptor medium and/or the supporting unit. The measuring unit measures the luminescence- and/or fluorescence behavior of the receptor medium and/or the target medium. The receptor medium and/or the target medium alternate the luminescence characteristics. The target medium is contacted with the receptor medium in solvable manner. The measuring unit measures and evaluates the intensity and/or the damping behavior of a luminescence light produced from the receptor medium and/or from the target medium. The measuring unit and supporting unit are coordinated on each other and are fastenable on a cap. The measuring unit is arranged in an optical oxygen sensor. The supporting unit acts as exchangeable sensitive element that is associated with the measuring unit. An optical stimulation of the receptor medium and an optical detection of the luminescence radiation and/or fluorescence radiation are enabled by the measuring unit. The measuring unit measures and evaluates the measurable size of the receptor medium and/or the target medium by an optical method or spectral analysis. Two different receptor mediums are intended, which are associated with two different target mediums. The measuring unit measures the measurable size of the two different receptor mediums and/or two different target mediums by using radiation with different wavelength and/or with different energy. The measuring unit irradiates white light and/or light with several wavelengths on the receptor mediums. The two different receptor mediums are arranged in positions one upon the other on the supporting unit and are connected with the specified target medium after an optical activation of light with different and/or identical wavelength. The measuring unit and/or supporting unit are removable from the transport medium by an interchangeable fitting. A secondary-measuring unit is intended for measuring second process variable of the target mediums and/or transport mediums. A comparison unit is intended for comparing a measured value of the measuring unit and a measured value of the secondary measuring unit on plausibility. The plausibility refers to the measurement of the measuring unit and/or to a process connected with the target medium and/or the carrier medium. The second process variable is measured with adhesion and/or oxygen-content and/or pH valve of the molecule. The measuring unit allows a predictive maintenance-message. The receptor medium and a modified target medium are acted at a luminescence marker. The modified target medium is intended in which the receptor medium is partially loaded. The receptor medium is specifically assigned as a function of a chemical, biological and/or different target medium that is physically pretreated. The supporting unit has a glass plate and consists of porous material. The receptor medium is fixed on the supporting unit, is connected with the specifically assigned target medium and activates a molecule section of the receptor medium. The receptor medium suffices hygienic and/or pharma-centric requirements, is assigned to a special enzyme and/or a special messenger and/or a special protein as target medium and indicates the presence of a special target protein and/or a wellness value of the target medium. The transportation medium is present in a process of the process- and automatic control. A separation unit (4) and/or a membrane are intended between the process and the measuring unit. The transport medium remains in the process during the measurement. A sample removal unit is intended, which removes the sample from the process for the measurement of the device. A bypass is intended, through which the transport medium flows for the measurement of the device. A calibration unit is intended for calibrating the measuring unit. An independent claim is also included for a method for the determination of the concentration of a biological substance or biological molecule.