Patent SG-11201909646T-A (SG)
Title: Trem2 antigen binding proteins and uses thereof
Inventor: FOLTZ IAN
IPC: A61K39/00
Filed: 2018-04-20
Abstract: 3 9„.:-401.73 :'En :P1,4 o 75(.....t.._1 176 (4C5) 1 77 (:1(.1 ., frai.0 HUigG2 i:50 :Rat icKi2b 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT o °nolo mu H loolloiliflo oimIE (10) International Publication Number WO 2018/195506 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/028691 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/488,691 21 April 2017 (21.04.2017) US 62/530,753 10 July 2017 (10.07.2017) US 62/580,400 01 November 2017 (01.11.2017) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center, Thousand Oaks, California 91320 (US). (72) Inventors: FOLTZ, Ian; 2018 Knightswood Place, Burn- aby, British Columbia V5A 4B9 (CA). SAMBASHIVAN, Shilpa; 58 Callie Lane, Menlo Park, California 94025 (US). CHEN, Irwin; 1875 Kelton Avenue #202, Los An- geles, California 90025 (US). HARRIS, Susie Miki; 197 Los Vientos Drive, Newbury Park, California 91320 (US). TOLEDO WARSHAVIAK, Dora; 6643 Buttonwood Av- enue, Oak Park, California 91377 (US). DRIVER, Ian; 301 Monterey Boulevard, Apt #4, San Francisco, Califor- nia 94131 (US). LU, Daniel; 5551 Castle Glen Avenue, San Jose, California 95129 (US). (74) Agent: LUO, Chenghua; One Amgen Center, Thousand Oaks, California 91320 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = (54) Title: TREM2 ANTIGEN BINDING PROTEINS AND USES THEREOF Coo.00 rotkin OM) FIG. 1A O 00 O N O (57) : The present invention relates to antigen binding proteins, such as monoclonal antibodies, that specifically bind to and activate human triggering receptor expressed on myeloid cells-2 (TREM2) and pharmaceutical compositions comprising such antigen binding proteins. The agonist antigen binding proteins (e.g. antibodies) of the invention are capable of activating TREM2/DAP12 signaling in myeloid cells in the absence of Fc-mediated cross-linking of the antigen binding proteins. Methods of treating or preventing conditions associated with TREM2 loss of function, such as Alzheimer's disease and multiple sclerosis, using the antigen binding proteins are also described. [Continued on next page] WO 2018/195506 Al MIDEDIM01101 DIDIIMEN11111111111111H1001111111111111101111111111 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))