Patent SG-11201407674T-A (SG)
Title: D-amino acid compounds for liver disease
Inventor: MAYES BENJAMIN ALEXANDER
IPC: C07H19/20
Filed: 2013-05-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177219 A1 (51) International Patent Classification: C07H19/10 (2006.01) C07H19/20 (2006.01) (21) International Application Number: (74) Agents: PATHAK, Rahul et al.; Squire Sanders (US) LLP, 275 Battery Street, Suite 2600, San Francisco, Cali­ fornia 94111 (US). (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data 61/650,414 61/695,218 61/711,131 61/716,874 61/726,521 61/726,522 61/739,509 61/772,325 61/792,131 61/807,249 61/807,268 61/807,266 22 May 2012 30 August 2012 8 October 2012 22 October 2012 14 November 2012 14 November 2012 19 December 2012 4 March 2013 15 March 2013 (15.03.2013) 1 April 2013 1 April 2013 1 April 2013 PCT/US2013/042104 (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 21 May 2013 (21.05.2013) English English (22.05.2012) (30.08.2012) (08.10.2012) (22.10.2012) (14.11.2012) (14.11.2012) (19.12.2012) (04.03.2013) (01.04.2013) (01.04.2013) (01.04.2013) US us us us us us us us us us us us (71) (72) Applicants: IDENIX PHARMACEUTICALS, INC. [US/US]; 320 Bent Street, Floor 4, Cambridge, Massachu­ setts 02141 (US). CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3 Rue Michel-Ange, F-75794 Paris Cedex 16 (FR). UNI- VERSITE MONTPELLIER 2 SCIENCES ET TECH­ NIQUES [FR/FR]; 2 Place Eugene Bataillon, F-34095 Montpellier Cedex 5 (FR). Inventors: MAYES, Benjamin Alexander; 69 Phillips Street, Apt. 2, Boston, Massachusetts 02114 (US). STEW­ ART, Alistair James; 28 Old Sudbury Road, Lincoln, Massachusetts 01773 (US). MOUSSA, Adel M.; 34 New­ bridge Avenue, Burlington, Massachusetts 01803 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) o\ i-H CJ l> l> i-H o CJ (54) Title: D-AMINO ACID COMPOUNDS FOR LIVER DISEASE (57) Abstract: Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver dis­ ease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.