baber/WOPTO huggingface dataset:
Patent WO-2021127042-A1 (WO)
Title: Combinations
Inventor: SAMATAR AHMED
IPC: A61K31/437
Filed: 2020-12-16
Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a Bcl-2 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.
Patent WO-2021133631-A1 (WO)
Inventor: PATEL NAYAN
IPC: F16H3/66
Filed: 2020-12-17
Abstract: A multi-speed transmission including a plurality of planetary gearsets and a plurality of selective couplers to achieve at least nine forward speed ratios and at least nine reverse speed ratios is disclosed. The plurality of planetary gearsets may include a first planetary gearset, a second planetary gearset, a third planetary gearset, a fourth planetary gearset, and a fifth planetary gearset. The plurality of selective couplers may include a number of clutches and a number of brakes. The multi-speed transmission may have five planetary gearsets and eight selective couplers. The eight selective couplers may include three clutches and five brakes.
Patent WO-2021127421-A1 (WO)
Title: Animal monitoring system incorporating a mmwave device
Inventor: TODDES STEVEN
IPC: A61B5/02
Filed: 2020-12-18
Abstract: An animal monitoring system that is configured to monitor circadian rhythms, respiration, heart rate and motor activity in a test animal includes a mmWave sensor device for detecting a position of the animal contained within an enclosed enclosure. The data obtained from the mmWave sensor device can be used to determine the breathing rate (respiration) and heart rate of the animal.
Patent WO-2021133958-A1 (WO)
Title: Systèmes et procédés d'évaluation de risque de septicémie
Inventor: HEADEN DEVON M
IPC: A61B5/00
Filed: 2020-12-23
Abstract: Certains aspects de la présente invention concernent de manière générale un procédé d'identification d'un risque de septicémie dans le corps d'un patient. Le procédé comprend l'étape consistant à mesurer des concentrations de lactate associées au corps pendant une ou plusieurs périodes de temps. Le procédé comprend en outre l'étape consistant à identifier le risque de septicémie sur la base des concentrations de lactate.
Patent WO-2021138381-A1 (WO)
Title: Methods for analyzing aav capsid proteins
Inventor: DAUD KUNAL
IPC: C07K14/14
Filed: 2020-12-30
Abstract: Provided are methods to characterize the VP1, VP2 and VPS capsid proteins in an adeno-associated virus (AAV) particle using liquid chromatography mass spectrometry, and/or ultraviolet (UV)-visible spectroscopy. The methods generally include the steps of (a) subjecting an AAV particle to liquid chromatography to denature and then separate the VP1, VP2 and VPS capsid proteins, and (b) subjecting the separated VP1, VP2 and VPS capsid proteins produced in step (a) to UV and mass spectrometry to determine the ratio and masses of the VP1, VP2 and VPS capsid proteins in the AAV particle. In another aspect, the disclosure provides an AAV composition comprising a post-translation modification. The disclosure also provides methods for characterizing the purity of AAV compositions using liquid chromatography mass spectrometry.
Patent WO-2022146423-A1 (WO)
Title: Caractérisation de réservoir à l'aide de techniques d'apprentissage automatique
Inventor: SAIKIA KALYAN
IPC: E21B47/26
Filed: 2020-12-30
Abstract: Un système peut déterminer un emplacement pour des puits futurs à l'aide de techniques d'apprentissage automatique. Le système peut recevoir des données sismiques concernant une formation souterraine et peut déterminer un ensemble d'attributs sismiques à partir des données sismiques. Le système peut former un bloc de l'ensemble d'attributs sismiques dans un ensemble d'attributs sismiques en bloc en répartissant l'ensemble d'attributs sismiques sur une grille géo-cellulaire représentative de la formation souterraine. Le système peut appliquer un modèle d'apprentissage machine formé à l'ensemble d'attributs sismiques en bloc pour générer un paramètre sismique composite. Le système peut répartir le paramètre sismique composite dans la formation souterraine pour caractériser des emplacements de formation sur la base d'une présence prédite d'hydrocarbures.
Patent WO-2020223744-A1 (WO)
Inventor: ROEIN PEIKAR SEYED
IPC: A61C7/14
Filed: 2020-05-02
Abstract: Orthodontic appliances and methods of manufacturing are disclosed. Manufacturing an appliance can include obtaining position data corresponding to an original tooth arrangement (OTA) of a patient's teeth, obtaining data corresponding to a desired final tooth arrangement (FTA) of the patient's teeth, and determining displacements between the OTA data and the FTA data. Based on the determined displacements, a configuration of an orthodontic appliance is determined. The appliance includes an anchor configured to be positioned adjacent the patient's teeth, and a plurality of arms each extending away from and coupled to the anchor, the arms configured to be secured to the patient's teeth. When the appliance is installed, the arms urge individual teeth from the OTA toward the FTA.
Patent WO-2020252495-A1 (WO)
Title: Methods of recovering active materials from rechargeable batteries, and related apparatuses
Inventor: MCNALLY JOSHUA S
IPC: C25C1/10
Filed: 2020-05-28
Abstract: A method of recovering active materials from a rechargeable battery comprises placing an active material of a rechargeable battery in a cathode chamber comprising a cathode of an electrochemical cell comprising the cathode chamber, an anode chamber comprising an anode, and a membrane separating the cathode chamber from the anode chamber, contacting the active material in the cathode chamber with an electrolyte comprising an acid, ferric ions, and ferrous ions, and dissolving at least one of lithium and cobalt from the active material into the electrolyte. Related apparatuses for recovering metals from active materials of rechargeable batteries are also disclosed.
Patent WO-2021035252-A1 (WO)
Title: Trunk line window controllers
Inventor: SHRIVASTAVA DHAIRYA
IPC: E06B9/24
Filed: 2020-08-18
Abstract: A trunk line for providing a communication path to a network of optically switchable windows is described.
Patent WO-2021141858-A1 (WO)
Inventor: ANDERSEN DEAN
IPC: A61N1/02
Filed: 2021-01-04
Abstract: L'invention concerne des techniques d'étalonnage d'une horloge basse fréquence (LF) d'un IMD, l'IMD comprenant également une horloge haute fréquence (HF). Lesdites techniques comprennent la détermination d'une moyenne, ou d'un substitut de cette dernière, du nombre de cycles d'horloge HF d'un signal d'horloge HF (produit par l'horloge HF) qui se produisent par cycle d'horloge LF d'un nombre prédéterminé N de cycles d'horloge LF du signal d'horloge LF (produit par l'horloge LF), N étant un nombre entier qui est au moins 2. Lesdites techniques comprennent également la comparaison de la moyenne ou d'un substitut de cette dernière à une valeur cible correspondante à laquelle la moyenne ou le substitut de cette dernière serait égal si la fréquence du signal d'horloge LF était égale à une fréquence cible pour l'horloge LF, la valeur cible correspondante n'ayant pas besoin d'être un nombre entier. L'horloge LF est étalonnée par ajustement de sa fréquence sur la base des résultats de la comparaison.
Patent WO-2021142034-A1 (WO)
Title: Vessel compression with hemodynamic wave reflection to control vascular wave dynamics and enhance blood flow
Inventor: CSETE MARIE
IPC: A61M60/32
Filed: 2021-01-06
Abstract: A system configured to be at least partially implanted along an aorta (110) includes an inelastic, static member (104, 108) and a pinching member (102, 106). The pinching member is configured to receive an activation signal at an activation rate and in response to the activation signal, repeatedly compress the aorta (110) at the second location at the activation rate to pump fluid within the aorta in a desired pumping direction. The system is configured to selectively control wave reflections in order to achieve both improved wave dynamics to reduce cardiac load and increased (or at least non- diminished) blood flow to targeted organs within the cardiovascular system.
Patent WO-2021142306-A1 (WO)
Title: Variational autoencoder for biological sequence generation
Inventor: GIESSEL ANDREW
IPC: G06N3/08
Filed: 2021-01-08
Abstract: Techniques for manufacturing a variant of a target protein. The techniques may include accessing a latent variable statistical model (LVSM) configured to generate output indicating one or more biological sequences corresponding to one or more variants of the target protein and using the LVSM to generate a first output indicating a first biological sequence associated with a first variant of the target protein. The techniques further include manufacturing, using the first biological sequence, a first biological molecule to produce the first variant of the target protein.
Patent WO-2021155096-A1 (WO)
Title: Articles and methods for blood separation
Inventor: MACE CHARLES
IPC: B01D21/34
Filed: 2021-01-29
Abstract: Disclosed herein are articles and methods for blood separation. For example, inventive articles and methods that remove red blood cells from blood samples are described.
Patent WO-2021158698-A1 (WO)
Title: Muscarinic receptor 4 antagonists and methods of use
Inventor: HARRIOTT NICOLE
IPC: A61K31/5386
Filed: 2021-02-03
Abstract: The present invention relates to compounds of Formula (Ia), pharmaceutically acceptable salts of compounds of Formula (Ia), and pharmaceutical compositions thereof that modulate the activity of the muscarinic acetylcholine receptor M4. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present invention are directed to methods useful in the treatment or prophylaxis of a neurological disease, disorder, or symptom, and conditions related thereto.
Patent WO-2021158979-A1 (WO)
Title: Support for test device
Inventor: DAVIS STEVEN
IPC: B01L9/00
Filed: 2021-02-05
Abstract: A support holder for a test device is disclosed, wherein the holder may include a base having a first plurality of sidewalls having a first length and a second plurality of sidewalls having a second length, wherein the second length is greater than the first length, wherein the plurality of sidewalls define a cavity in the base, the cavity including a surface for receiving a portion of the test device; and a plurality of projections extending away from the base, wherein each projection of the plurality of projections is configured to be associated with a leg portion, and wherein a first sidewall of the first plurality of sidewalls includes a center notch positioned between a first comer portion and a second comer portion, and wherein a second sidewall of the first plurality of sidewalls includes a removable portion configured to cover an opening into an interior of the base.
Patent WO-2021163498-A1 (WO)
Title: Retrograde neuronal tracers detectable by fluorescence and other imaging methods
Inventor: GIANNESCHI NATHAN C
IPC: C09K11/06
Filed: 2021-02-12
Abstract: Disclosed is composition comprising: a first fluorophore moiety, and nanoparticles, wherein the nanoparticles comprise: a first plurality of a first nanoparticle, the first nanoparticle comprising: a first outer surface, a first interior bulk, and a first polymer, wherein the first polymer is covalently bonded to the first fluorophore moiety within the first interior bulk of the first nanoparticle. Also disclosed is a composition comprising: a chelate moiety, and nanoparticles, wherein the nanoparticles comprise: a plurality of a chelate nanoparticle, the chelate nanoparticle comprising: an outer surface, an interior bulk, and a polymer, wherein the polymer is covalently bonded to the chelate moiety within the interior bulk of the chelate nanoparticle. Also disclosed are methods of making such compositions and using such composition for brain mapping and tracing of axonal projections.
Patent WO-2021221761-A1 (WO)
Inventor: PLAHEY KULWINDER
IPC: A61M1/16
Filed: 2021-02-16
Abstract: Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cassette (e.g., a disposable cassette) positionable within a port formed in the dialysis machine. The dialysis system may also include a cleaning cartridge insertable into the port. The cleaning cartridge may be arranged and configured to collect, remove, etc. any foreign material or debris from the port.
Patent WO-2021168074-A1 (WO)
Title: Macrocyclic compounds and uses thereof
Inventor: HUANG WEI-SHENG
IPC: A61P35/00
Filed: 2021-02-18
Abstract: Described herein are macrocyclic compounds of Formula (I), which can inhibit kinases such as EGFR, including mutant forms such as T790M EGFR mutants. Also described herein are pharmaceutical compositions comprising a compound of Formula (I), or any pharmaceutically acceptable form thereof, processes for their preparation, and use in therapy for the prevention or treatment of cancer. In particular, compounds described herein can be effective for treating EGFR-driven cancers including non-small cell lung cancer (NSCLC).
Patent WO-2021194794-A1 (WO)
Inventor: RICHARD DIDIER
IPC: F16H55/22
Filed: 2021-03-16
Abstract: The present disclosure relates to a globoid worm gear (4) for engagement with a worm (3) in a worm gear assembly (1). The globoid worm gear (4) includes first and second side surfaces (17, 18), a circumferential surface (10), and an axis of rotation. The globoid worm gear (4) also includes a plurality of gear teeth (9) spaced about the circumferential surface (10) with spaces (11) arranged between adjacent gear teeth (9), the plurality of gear teeth (9) being configured to engage the worm (3). The plurality of gear teeth (9) are configured such that the spaces (11) between adjacent gear teeth (9) open into the first side surface (17).
Patent WO-2021207380-A1 (WO)
Title: Therapeutic strategies to manage facial contractures post injury
Inventor: ROY SASHWATI
IPC: A61K9/50
Filed: 2021-04-07
Abstract: Compositions and methods are provided for reducing facial contracture and to alleviate deficits associated with thermal injury of the face, including ectropion (epithelial-ocular junction), eversion of the lip (epithelial-oral junction), and oral incompetence (drooling). In accordance with one embodiment such compositions are used in conjunction with known treatments for use on burn patients.
Patent WO-2021222466-A1 (WO)
Title: Composés hétérocycliques en tant qu'inhibiteurs de bet
Inventor: PHAM SON MINH
IPC: C07D213/64
Filed: 2021-04-28
Abstract: L'Invention concerne de nouveaux inhibiteurs de bromodomaine et de domaine extraterminal (BET) et des procédés thérapeutiques pour le traitement de troubles et de maladies à l'aide de ces nouveaux inhibiteurs BET.
Patent WO-2021226017-A1 (WO)
Title: Apparatus and method for reducing bruxism and occlusal forces
Inventor: SIMONETTI SCOTT A
IPC: A61F5/56
Filed: 2021-05-04
Abstract: An oral orthotic device includes a body having a left portion including an upper surface and a right portion including an upper surface. The upper surface of the left portion and the upper surface of the right portion define a plane positioned to extend above an irregular surface defined by teeth of a user. A bite block extends from the upper surface of one of the left portion or the right portion a distance above the plane such that the bite block is disposed on the oral orthotic device exclusively on either the left portion or the right portion. One or more springs extend from the body and are configured to buffer the body from the teeth of the user. A lingual portion is coupled to the left portion of the body and to the right portion of the body. The lingual portion encloses a helical wire.
Patent WO-2021236584-A1 (WO)
Title: Methods, compositions, and kits for nucleic acid detection
Inventor: KENTEN JOHN
IPC: G01N33/68
Filed: 2021-05-18
Abstract: The invention relates to methods, oligonucleotide reagents, compositions, and kits for nucleic acid detection.
Patent WO-2021252469-A1 (WO)
Title: Model featuring n-porosity
Inventor: LIU CHAO
IPC: E21B43/26
Filed: 2021-06-08
Abstract: The subject matter of this specification can be embodied in, among other things, a method for determining leak-off rate includes receiving a collection of geological data descriptive of a well path through a predetermined geographical area, the geological data comprising fracture density and fracture distribution data obtained from offset wellbore image and wellbore nuclear magnetic resonance logs, determining a hydraulic fracturing fluid leak-off rate based on the received collection of geological data, and providing the determined hydraulic fracturing fluid leak-off rate.
Patent WO-2021257642-A1 (WO)
Title: Methods of manufacturing a glass ribbon
Inventor: AMADON JEFFREY ROBERT
IPC: C03B17/06
Filed: 2021-06-16
Abstract: A method of manufacturing a glass ribbon can comprise flowing a glass-forming ribbon along a travel path. The glass-forming ribbon can comprise a first major surface and a second major surface opposite the first major surface. A thickness can be defined between the first major surface and the second major surface. The method can comprise heating the first major surface of the glass-forming ribbon at a target location of the travel path while the glass-forming ribbon is travelling along the travel path. The heating can increase a temperature of the glass-forming ribbon at the target location to a heating depth of about 250 micrometers or less from the first major surface. The method can comprise cooling the glass-forming ribbon into the glass ribbon. Prior to the heating, the glass-forming ribbon at the target location can comprise an average viscosity in a range from about 1,000 Pascal-seconds to about 1011 Pascal-seconds.
Patent WO-2021257696-A1 (WO)
Title: Isoform-specific aldehyde dehydrogenase inhibitors
Inventor: CHEN JAMES KENNETH
IPC: A61K31/41
Filed: 2021-06-16
Abstract: Compounds and methods are provided for inhibiting an aldehyde dehydrogenase (ALDH). Methods of treating cancer are also provided. The ALDH-inhibitor can be a compound that is based on a cyclic guanidine, or an imidazolium core. In certain embodiments, the ALDH-inhibitor compound is a substituted cyclic guanidine, or a substituted imidazolium compound. Aspects of the methods include methods of selectively inhibiting a particular ALDH family member. In some cases, the subject compounds are ALDH1 B1-selective inhibitors. In some cases, the subject compounds are ALDH1A3-selective inhibitors.
Patent WO-2021257892-A1 (WO)
Inventor: ROY GAURAV
IPC: G16Y40/35
Filed: 2021-06-17
Abstract: Selon certains aspects de la présente divulgation, un mode de réalisation donné à titre d'exemple concerne un système, un procédé et un support de stockage destinés à la remédiation de l'empreinte carbone. Un processeur reçoit un ensemble de données d'utilisation en provenance de dispositifs informatiques. Le processeur détermine des données d'emplacement correspondant à des données d'utilisation d'un dispositif parmi les dispositifs informatiques. Le processeur détermine une empreinte carbone des dispositifs informatiques en fonction des données d'utilisation et des données d'emplacement. Le processeur compare l'empreinte carbone à un seuil d'empreinte carbone. Le processeur transmet des instructions de commande de remédiation, en fonction de la comparaison, aux dispositifs informatiques
Patent WO-2021257911-A1 (WO)
Inventor: SHLUZAS ALAN E
IPC: A61M5/315
Filed: 2021-06-17
Abstract: A system for injecting includes a syringe body, a syringe interior, a syringe flange, and a stopper member and an injectable fluid disposed in the syringe interior. The system also includes a plunger member coupled to the stopper member. The system further includes a finger flange removably coupled to the syringe flange, the finger flange defining a pair of side openings and a pair of bumps adjacent respective side openings. Moreover, the system also includes a swing spacer rotatably coupled to the finger flange, the swing spacer defining a pair of arms, a pair of pivot pins, two pairs of slots, and a pair of indentations. The swing spacer is configured to define a distance of movement of the plunger member relative to the syringe body along a longitudinal axis of the syringe body, thereby defining a dose of the injectable fluid.
Patent WO-2022250714-A1 (WO)
Inventor: JOHNSTON BENJAMIN M
IPC: G03F7/20
Filed: 2021-07-13
Abstract: A bridge stiffener assembly includes a first stiffener plate and a second stiffener plate, and clamp plates for securing the first stiffener plate and the second stiffener plate to a bridge structure of a digital lithography system. The clamp plates include a first pair of clamp plates disposed on a first end of the first stiffener plate, a second pair of clamp plates disposed on a second end of the first stiffener plate and a first end of the second stiffener plate, and a third pair of clamp plates disposed on a second end of the second stiffener plate. The bridge stiffener assembly further includes reinforcement beams including a first reinforcement beam disposed on the first pair of clamp plates, a second reinforcement beam disposed on the second pair of clamp plates, and a third reinforcement beam disposed on the third pair of clamp plates.
Patent WO-2022020171-A1 (WO)
Title: Methods and devices for optimizing contrast for use with obscured imaging systems
Inventor: RANALLI ELISEO
IPC: G02B17/06
Filed: 2021-07-15
Abstract: A system for outputting partially spatially coherent light to an imaging system is disclosed herein, which includes a spatially coherent light source configured to output a spatially coherent signal, at least one optical device having an optical device body with a first device surface formed thereon and configured to reflect a portion of the spatially coherent signal to form at least one coherent reflected signal. The optical device body also includes a second device surface having one or more surface irregularities configured to diffuse a portion of the spatially coherent light source output signal transmitted through the optical device body, to produce at least one spatially incoherent signal. The combination of the coherent reflected signal and the spatially incoherent signal form the partially spatially coherent light signal.
Patent WO-2022026617-A1 (WO)
Inventor: SPRINGER LINDSAY
IPC: A23G9/04
Filed: 2021-07-28
Abstract: A frozen product machine that solves problems associated with conventional home ice cream and frozen product machines by prevents loss of product in the chamber and decreases freezing time for a liquid product. A cooling chamber is cooled by a cooling element that provides variable cooling temperatures throughout the cooling chamber. A temperature gradient, progressing from lower temperatures at the bottom of the chamber, or the outlet, to higher at the top of the chamber, or inlet, create a more efficient means of cooling a frozen product. An auger, that may be shaped to match the shape of the cooling chamber may include slots that allow for controlled flow of frozen product through the chamber to promote efficient cooling. Hinged fins may rotate from open to closed within the slot to further enhance flow of frozen product through the frozen product machine.