Patent SG-11201908092R-A (SG)
Title: Anti-tigit antigen-binding proteins and methods of use thereof
Inventor: NIELSON NELS
IPC: C07K16/28
Filed: 2018-03-30
Abstract: co ;\ 0 Ns° A \O • 0 n _ f0 P c (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIP0 I PCT Hu onus °nolo Eno iflo oimIE (10) International Publication Number WO 2018/183889 Al (51) International Patent Classification: C07K 16/22 (2006.01) A61K 39/00 (2006.01) CO7K 16/28 (2006.01) (21) International Application Number: PCT/US2018/025460 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,042 30 March 2017 (30.03.2017) US (71) Applicant: POTENZA THERAPEUTICS, INC. [US/US]; 1030 Massachusetts Avenue, Suite 210, Cam- bridge, MA 02139 (US). (72) Inventor; and (71) Applicant: STEINER, Philipp [CH/US]; c/o Potenza Therapeutics, Inc., 1030 Massachusetts Avenue, Suite 210, Cambridge, MA 02139 (US). (72) Inventors: NIELSON, Nels, P.; c/o Potenza Therapeu- tics, Inc., 1030 Massachusetts Avenue, Suite 210, Cam- bridge, MA 02139 (US). HICKLIN, Daniel; c/o Potenza Therapeutics, Inc., 1030 Massachusetts Avenue, Suite 210, Cambridge, MA 02139 (US). SEIDEL-DUGAN, Cyn- thia; c/o Potenza Therapeutics, Inc., 1030 Massachusetts Avenue, Suite 210, Cambridge, MA 02139 (US). WINS- TON, William; c/o Potenza Therapeutics, Inc., 1030 Mass- achusetts Avenue, Suite 210, Cambridge, MA 02139 (US). BRODKIN, Heather; c/o Potenza Therapeutics, Inc., 1030 Massachusetts Avenue, Suite 210, Cambridge, MA 02139 (US). SALMERON-GARCIA, Jose-Andres; c/o Poten- za Therapeutics, Inc., 1030 Massachusetts Avenue, Suite 210, Cambridge, MA 02139 (US). NIRSCHL, Christo- pher, James; c/o Potenza Therapeutics, Inc., 1030 Massa- chusetts Avenue, Suite 210, Cambridge, MA 02139 (US). (74) Agent: KABLER, Kevin et al.; Fenwick & West LLP, 801 Calfornia Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) Title: ANTI-TIGIT ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF 1 mg/mL CMV (57) : Provided herein are antigen-binding proteins (ABPs) that selectively bind to TIGIT and its isoforms and homologs, and 0 compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods. o [Continued on next page] aPD-1 Pernbrolizu ma b) Figure 1A cc cc cc 00 WO 2018/183889 Al MIDEDIMOMOIDEIREEMOMOEIMMHEHOMEEN MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))