baber/WOPTO huggingface dataset:
Patent NZ-503076-A (NZ)
Title: 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives and addition salts thereof, with antagonism against amino acid receptors (particularly AMPA receptor) and processes for their preparation
Inventor: SHIGA FUTOSHI
IPC: C07D403/12
Filed: 1998-08-28
Abstract: 6,7-Asymmetrically disubstituted quinoxalinecarboxylic acid derivatives represented by a general formula (1) wherein; Q is halogen, alkyl optionally substituted with halogen, or Ar-P-, where Ar is optionally substituted phenyl or naphthyl and P is alkylene, alkenylene, alkynylene, oxygen or sulfur, L-A-, wherein L is of general formula (4) wherein; V is a single bond, alkylene or alkenylene; T is phenyl, naphthyl, heterocycle and its condensed ring, hydrogen, hydroxyl, thiol, optionally substituted amino, alkoxycarbonyl, carboxyl or aldehyde, general formula (4-a) or (4-b) wherein; U and X are oxygen or sulfur; W is aralkyl, phenyl, naphthyl, optionally substituted heterocycle and its condensed ring or alkyl optionally substituted with halogen or cycloalkyl; R3 is aralkyl, phenyl, naphthyl, optionally substituted heterocycle and its condensed ring, hydrogen, alkyl optionally substituted with halogen or cycloalkyl, or general formula (4-c), wherein; X is oxygen or sulfur; W is aralkyl, phenyl, naphthyl, optionally substituted heterocycle and its condensed ring, alkyl optionally substituted with halogen or cycloalkyl; R4and R5 are aralkyl, phenyl, naphthyl, optionally substituted heterocycles and their condensed rings, hydrogen, alkyl optionally substituted with halogen or cycloalkyl; Ring B is an optionally substituted heterocycle and its condensed ring which may contain oxygen, nitrogen or sulfur; m denotes 0 or 1; A is a single bond, alkylene, alkenylene or alkynylene; or Q is general formula (5), wherein; R6 and R7 are hydrogen, alkyl optionally substituted with halogen, cycloalkyl, or optionally substituted phenyl or aralkyl; R1 is aralkyl, phenyl, naphthyl, optionally substituted heterocycle and its condensed ring, hydrogen, alkyl optionally substituted with halogen or cycloalkyl; R2 is a hydroxyl, alkoxy or general formula (6), wherein; R8 and R9 are aralkyl, phenyl, optionally substituted heterocycles and their condensed rings, hydrogen, alkyl optionally substituted with halogen or cycloalkyl, or R8 and R9 may form a ring together with nitrogen, or either of R8 and R9 are hydrogen while the other is a optionally substituted phenyloxy or aralkyloxy hydroxyl group or lower alkoxy group, and R is nitro, trifluoromethyl, optionally substituted amino or general formula (7), wherein; R10 and R11 are aralkyl, phenyl, optionally substituted heterocycles and their condensed rings, hydrogen, alkyl optionally substituted with halogen or cycloalkyl, or R10 and R11 may form a ring together with nitrogen and n is 1 to 2; and their addition salts.
Patent NZ-505080-A (NZ)
Title: Pharmaceutical formulations containing a compound having an amidine group stabilized by an acid
Inventor: BADAWY SHERIF I
IPC: C07D261/04
Filed: 1999-01-14
Abstract: A pharmaceutical composition comprising a tablet or capsule or other solid dosage form contains a pharmacologically effective amount of a compound of formula (I), or its salt, a pharmaceutically acceptable solid carrier, and a pharmaceutically acceptable acid in an amount to modify the pH of the composition to a pH of 4. A process of stabilizing the compound of formula (I) against hydrolysis, by adding water during formulation manufacture and contacting the compound during formulation manufacture with a pharmaceutically acceptable acid having a pH of 4 in a saturated aqueous solution is described.
Patent NZ-506055-A (NZ)
Title: The removal of causative agent(s) of TSE from protein solutions using adsorbent from kieselguhr, diatomaceous earth, siliac acid, clay minerals, metal hydroxide, metal oxihydrate, cellulose, perlite, bentonite and water insoluble synthetic polymers
Inventor: MORGENTHALER JEAN-JACQUES
IPC: A61K35/14
Filed: 1998-12-14
Abstract: A method for separating non-conventional transmissible agents (NCTAs) i.e. causative agents of transmissible spongiform encephalopathies (TSE), from a protein solution, particularly from human blood products. The solution and at least one adsorbent are suspended for at least 10 minutes during which the suspension is agitated. The adsorbent is then separated from the protein solution. The adsorbent is selected from at least one of kieselguhr, diatomaceous earth, silicic acid, clay minerals, metal hydroxide, metal oxihydrate, cellulose, perlite, bentonite and water insoluble synthetic polymers.
Patent NZ-508932-A (NZ)
Title: Method of preventing bacteriophage infection of bacterial cultures
Inventor: NILSSON DAN
IPC: A23C19/032
Filed: 1999-07-02
Abstract: A method of modifying a substrate material by means of a bacterial culture which is capable of being metabolically active in said substrate, whereby the bacterial culture is not susceptible to attack by bacteriophages, the method comprising: (a) Isolating a bacterial strain which is not capable of DNA replication, RNA transcription or protein synthesis in said substrate material but is capable of metabolically modifying the substrate material; (b) Propagating the selected strain in a medium wherein the strain is capable of replicating to obtain a culture of said strain; (c) Adding the obtained bacterial culture to the substrate material and keeping the material under conditions where the culture is metabolically active. The method is useful in the manufacturing of food products, feed products or useful metabolite products.
Patent NZ-515836-A (NZ)
Title: Method for extracting the natural juice of ligneous plant material, device for carrying out said method and use of said method in the production of dried ligneous plant material
Inventor: DEDIEU BERNARD
IPC: F26B7/00
Filed: 2000-04-28
Abstract: A  method for extracting the natural juice of ligneous plant  material, a device for carrying out said  method  and the  use  of said method in the production of dried ligneous plant  material. The method for extracting the natural juice of  ligneous  plant  material  comprises  the  following:  a pressurization  step in which a sealed enclosure  containing the  plant  material  is pressurized, whereby  the  pressure thereof  is greater than that of the atmosphere; a stage  in which  saturating  water vapour is created  or  injected;  a stage  in which the plant material is heated to the core  by means  of electromagnetic waves; a step in which the  liquid exudates   from  said  plant  material  are  gravitationally recovered.
Patent NZ-528942-A (NZ)
Title: Methods for large-scale production of recombinant rAAV vectors
Inventor: BYRNE BARRY J
IPC: C12N15/869
Filed: 1999-09-22
Abstract: Disclosed is a method of serial amplification of recombinant adeno-associated virus (rAAV). The method includes the steps of: (f) infecting a competent host cell line with a rAAV and an ICP27 defective herpes virus comprising an AAV rep gene and an AAV cap gene, each operably linked to a homologous or heterologous promoter; (g) culturing the host cell under conditions effective to produce rAAV; (h) lysing said cell to obtain a lysate; (i) amplifying rAAV from said lysate through serial passaging; and (j) collecting the rAAV so produced. Wherein amplification is at least 200-fold over amount of input rAAV vector at each passage. Suitable promoters include p5, p19, p40, hCMV, HSV-1 tk, CMV40, HIV LTR, HCMV IE and HSV-1 IE 110 promoter. The defective herpes virus may be d27.1rc or a herpes simplex virus. The total amplification may be greater than 106 after 3 cycles of passaging. Said method is useful for multiplying rAAV including a therapeutic transgene. (62) Divided Out of 511171
Patent NZ-531806-A (NZ)
Title: A semi solid composition comprising a vasoactive prostaglandin, skin penetration enhancer, shear-thinning polysaccharide, lipophilic compound in an acidic buffer system
Inventor: YEAGER JAMES L
IPC: A61K47/14
Filed: 2002-09-06
Abstract: Disclosed herein is a semi-solid composition that comprises a vasoactive prostaglandin; a skin penetration enhancer; a shear-thinning modified galactomannan gum; a lipophilic compound; water and an acidic buffer system. Also disclosed is the use of said composition for the preparation of a pharmaceutical composition for treating erectile dysfunction in a patient needing such treatment, whereby the pharmaceutical composition is suitable for application to the fossa navicularis of the patient.
Patent NZ-533511-A (NZ)
Title: Methods using glycoconjugates to treat brain tumors and diagnose cancer
Inventor: BOGOCH SAMUEL
IPC: C07K1/00
Filed: 1999-08-30
Abstract: The use of a therapeutically effective amount of an isolated glycoconjugate peptide comprises an amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 for the manufacture of a medicament for treating brain tumors. Also described is an ex vivo method for diagnosing cancer in a patient comprising the determination of the presence of a peptide consisting of SEQ ID NO:1 or SEQ ID NO:2 in the patient's blood.
Patent NZ-534677-A (NZ)
Title: Model generation and distribution system
Inventor: MOONEY DALE EDWARD
Filed: 2004-08-18
Abstract: Methods for distributing 3-dimensional model data to remote users are disclosed. A set of 3-dimensional data associated with a physical item is captured (A) and stored (B) at a central data store. Remote end users request abridged model data in a selected format. The abridged model is generated (C) at the data store and transmitted (D) to the end user using internet protocols. The abridged model may have reduced accuracy and resolution compared to the stored data, which allows for easier and faster transmission of the 3-dimensional model data.
Patent NZ-537346-A (NZ)
Title: Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
Inventor: SUBASINGHE NALIN
IPC: C07D409/14
Filed: 2003-05-28
Abstract: Disclosed are compounds of formula I wherein: Z is -S(O2)-; R1 is C1-6alkylthio or methylsulfonyl; and R5 is phenyl substituted by three substituents; one of the substituents being C1-4 alkyl or halo; the second substituent being C1-4alkyl, C1-4alkoxy, hydroxyl, amino, nitro, optionally substituted ureido or optionally substituted alkylcarbonylamino; and the third substituent being either optionally-substituted ureido, or optionally substituted guanidine. The compounds disclosed are used for inhibiting the enzyme C1s, a protease of the complement system and is useful in the treatment of disorders such as Crohn's disease, thermal injury, hemodialysis, ischaemia, allograft and xenograft rejection, and autoimmune diseases.
Patent NZ-539128-A (NZ)
Title: Device for discharging liquids, a cartridge suited therefor, and system comprised of the device for discharging liquids and of the cartridge
Inventor: SCHIEWE JOERG
IPC: A61M15/00
Filed: 2003-08-26
Abstract: A propellant gas-free device for discharging liquids; a cartridge which is adapted thereto and which is provided for storing the liquid; and the ensemble comprised of both the device and cartridge. The device comprises: an elastic element (15, 16) for the storage of a predetermined quantity of energy; a mobile element (6) to which the predetermined quantity of energy can be fed and which can expose the dosed fluid quantity to a predetermined increase in pressure; means (4, 12, 13, 14, 18, 19, 21, 22, 23, 27) for the respective introduction and removal of a container cartridge (10) containing the drug into and from an accommodation chamber (30) lying in the inside of the device; and means for the feeding of the pressurized drug to a dispensing facility (29) firmly connected to the container cartridge. The container cartridge is introduced into the accommodation chamber via an opening (4) in the housing wall (26) of the device. A part of the housing wall comprises a removable grip (18) which is provided with a holding means (12) for accommodating a container cartridge. The cartridge comprises a dimensionally stable, manually not deformable container cartridge (10) with a base part and a top part, the top part being formed by a dispensing facility (29) from which a stock cylinder (40) for accommodating a drug in dissolved or suspended form leads to the bottom of the container cartridge, which is closed by sealing means (59) not indestructibly removable from the container cartridge and/or a container punch (39) movable into the stock cylinder (40), sealing and not projecting outwards beyond the bottom area of the container cartridge, and/or by a rigid baseplate (63).
Patent NZ-541004-A (NZ)
Title: Cartridge with filter located below extraction material which is suspended during upward fluid movement and recollected during downward fluid movement
Inventor: FEE CONAN JEFFERY
Filed: 2005-06-28
Abstract: Filter 2 is located under extraction material 5 contained in the cartridge. During upward fluid movement the extraction material 5 is suspended in the fluid and is recollected in the cartridge on downward fluid flow.
Patent NZ-543322-A (NZ)
Title: The use of azetidinecarboxamide derivates in therapy
Inventor: DAVIDSON JAMES EDWARD PAUL
IPC: A61P43/00
Filed: 2004-04-29
Abstract: Disclosed is the use of a compound of formula (I), wherein R1 is substituted or unsubstituted aryl; R2 is H, substituted or unsubstituted alkyl or substituted or unsubstituted aryl; and R3 is hydrogen or substituted or unsubstituted alkyl; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of psychosis, schizophrenia, cognitive disorders, attention deficit disorder, gastrointestinal disorders, smoking cessation, obesity or other eating disorders associated with excessive food intake, or non-insulin dependant diabetes mellitus.
Patent NZ-545563-A (NZ)
Title: Process for the manufacture of an aqueous quick-setting bitumen-aggregate mix suitable for cold pavement of roads
Inventor: THORSTENSSON BENGT-ARNE
IPC: C09K23/14
Filed: 2004-06-23
Abstract: Disclosed is a method for manufacturing an aqueous quick-setting bitumen-aggregate mix suitable for cold pavement of roads, parking places, sidewalks and the like. The bitumen-aggregate mix is manufactured by mixing a mineral aggregate, water, a de-emulsifier at a temperature from 0 to 40 Deg. C, containing hydraulic cement, and a cationic oil-in-water bitumen emulsion, containing, as an emulsifier, a salt of a tertiary diamine and a phosphoric acid, wherein the diamine has the formula (I), where one or two of the groups R1, R2, R4 and R5 designate a hydrocarbon group of 6-22, preferably 8-20 carbon atoms, and the remaining R1, R2, R4 and R5 groups are an alkyl group with 1-4 carbon atoms, and/or a group -(A)sH, where A is an alkyleneoxy group with 2-3 carbon atoms, and s is a number from 1-4, R3 is an alkylene group with 2-4 carbon atoms.
Patent NZ-545666-A (NZ)
Title: Condensed ring compound and use thereof
Inventor: TAKEUCHI JUN
IPC: A61K45/00
Filed: 2004-08-31
Abstract: Disclosed is a compound of formula (I-a) wherein the substituents are as described in the specification. Also disclosed is the use of compound (I-a) for the manufacture of an agent for the prevention and/or treatment of the disease mediated by cysLT2 including respiratory disease such as asthma or obstructive pulmonary disease.
Patent NZ-545989-A (NZ)
Title: Treating or preventing restless legs syndrome using prodrugs of gaba analogs
Inventor: BARRETT RONALD W
IPC: A61K31/195
Filed: 2004-09-17
Abstract: Disclosed is the use of 1-{[(alpha-isobutanoyloxyethoxy)carbonyl]-aminomethyl}-1-cyclohexane acetic acid or a pharmaceutically acceptable salt, hydrate or solvate thereof in the manufacture of a medicament for the treatment or prevention of restless legs syndrome in a patient.
Patent NZ-547952-A (NZ)
Title: Methods and apparatuses for altering relative curvature of field and positions of peripheral, off-axis focal positions
Inventor: SMITH EARL LEO
IPC: G02C7/04
Filed: 2004-07-09
Abstract: An ocular device or system provides predetermined off-axis aberrations to deliver at least one predetermined stimulus in the peripheral field to an eye whilst predictably controlling the forward-backward positions of the off-axis points on the peripheral field relative to the on-axis focal points on the central field to produce at least one substantially corrective stimulus for altering eye growth by repositioning peripheral, off-axis, focal points relative to the central, on-axis or axial focal point while maintaining the positioning of the central, on-axis focal point on the retina with a predetermined on-axis prescriptive strength. The device will be used to provide continuous, useful clear visual images, maintaining substantial axial alignment with the eye, while simultaneously retarding or abating the progression of myopia or hypermetropia.
Patent NZ-552198-A (NZ)
Title: Device for coupling a loader to a tractor
Inventor: MAILLEUX LOIC
IPC: E02F3/627
Filed: 2005-06-06
Abstract: A device for coupling a loader to a tractor, wherein the hitching frame (1) of the loader is provided with two coupling projections (11, 12) or sockets (21, 22) and a latch (14) biased by a spring (15), the coupling head (2) of the tractor is provided with two complementary coupling members and locking means (25, 25'), and the latch (14) engages the locking means (25, 25') to lock the load onto the tractor. The device is characterised in that the coupling head (2) includes pre-locking means (24, 24') engageable by the latch (14) in a pre-locking position in which the projections (11, 12) and sockets (21, 22) are not fully coupled, and the spring (15) continually urges the latch (14) into the locking or pre-locking position.
Patent NZ-553299-A (NZ)
Title: Immune stimulatory infant formula with nucleotides and a negatively charged glycan or glycoconjugate
Inventor: BEERMANN CHRISTOPHER
IPC: A23L33/00
Filed: 2005-08-22
Abstract: Disclosed is the use of a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (NpxN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component, selected from the group consisting of a polygalacturonic acid with a DP between 2 and 100 and gangliosides, with a molecular weight between 200 and 20,000 dalton; and protein, fat and carbohydrate; for the manufacture of a composition for administration to a mammal for the treatment and/or prevention of an inflammatory disease, diarrhoea, eczema and/or atopic dermatitis.
Patent NZ-553555-A (NZ)
Title: Product distribution method
Inventor: PALMER ROGER KEITH
Filed: 2005-07-26
Abstract: A method for retail distribution of a plurality of objects is disclosed. The method includes the steps of: (a) receiving information as to a sequence in which the plurality of objects will be placed on one or more retail shelves; (b) providing a stacking apparatus which includes a container and a tray assembly where the container is adapted to accommodate the tray assembly and the tray assembly includes a plurality of tray members arranged one above another; (c) placing the plurality of objects on trays of the tray assembly in such a way that a first object earlier in the sequence than a second object is placed on a first tray and the second object is placed on a second tray; (d) placing the tray assembly in the container; (e) transporting the container to a retail outlet at which the retail shelves are located; (f) removing the tray assembly from the container, and; (g) moving each object from the tray assembly to the retail shelves in the sequence.
Patent NZ-561166-A (NZ)
Title: Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
Inventor: CHUN JONG-YOON
IPC: C12N15/11
Filed: 2006-03-03
Abstract: Disclosed is a dual specificity oligonucleotide with enhanced annealing specificity, which is represented by the following general formula 5'-Xp-Yq-Zr-3' wherein the substituents are as defined in the specification. Methods for synthesizing a nucleic acid using the dual specificity oligonucleotide are also disclosed.
Patent NZ-563267-A (NZ)
Title: Vacuum vessel for treatment of oils
Inventor: GULLOV-RASMUSSEN BJARNE
IPC: B01D3/34
Filed: 2006-04-26
Abstract: A vacuum vessel for continuous or semi-continuous treatment of oils in connection with deodorization comprises spaces 12 through which oil to be treated is brought to pass and means to heat or cool the oil in the form of U-tubes. There are perforated pipes 26 arranged at the bottom of the spaces to lead stripping gas into the oil. The vessel has a connection to a vacuum source (7). The spaces in the vessel are arranged such that the oil to be treated in the vessel flows through the same by gravity. The heating or cooling medium passing the U-tubes is arranged to be pumped there through. The U-tubes for heating or cooling medium are arranged in such a way in the spaces that the flow of oil is counter-current to the flow of heating or cooling medium all through the vessel and a number of U-tubes are arranged in groups, parallel and in rows above each other in the spaces.
Patent NZ-565373-A (NZ)
Title: Fastening device to propel fastener with combusition gas, with opening lever to move cannon forward relative to gun holder
Inventor: ALMERAS ROLAND
IPC: B25C1/14
Filed: 2006-06-29
Abstract: The device is intended to propel a fastening element (1) under the action of combustion gas from an explosive charge contained in a cartridge (10) mounted on a cartridge holder (13) received in a gun holder (3) and intended to be entered into a combustion chamber (11) situated at the rear of the cannon (4) slidably fitted in the gun holder (3). Also foreseen is an opening lever (19-25) designed to, after firing, draw the cannon (4) forward in the gun holder (3), bring it away from the cartridge holder (13) and thus open the device .
Patent NZ-569786-A (NZ)
Title: Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines
Inventor: LOSO MICHAEL R
IPC: A01N43/10
Filed: 2007-02-09
Abstract: Disclosed are N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compounds as represented by formula (I), wherein X represents NO2, CN or COOR4; L represents a single bond, or R1, S and L taken together represents a 4-, 5- or 6-membered ring; R1 represents alkyl; R2 and R3 independently represent hydrogen, alkyl, fluoro, chloro or bromo; n is an integer from 0-3; Y represents haloalkyl; and R4 represents alkyl. Of particular importance is the compound [1-(6-trifluoromethylpyridin-3-yl)ethyl](methyl)-oxido-l4-sulfanylidenecyanamide. Further disclosed is a composition for controlling insects which comprises a compound as defined above and one or more insecticides, fungicides or herbicides such as methoxyfenozide, spinosad, spinetoram, imidacloprid, acetamiprid, thiamethoxam, thiacloprid, dinotefuran, bifenthrin, clothianidin, zeta-cypermethrin, lambda-cyhalothrin, rynaxypyr and spirotetramat.
Patent NZ-578065-A (NZ)
Title: Methods for treating psoriasis with an antibody which binds to an epitope
Inventor: VALDES JOAQUIN MARIO
IPC: A01N37/18
Filed: 2008-01-16
Abstract: Disclosed is the use of an antibody, or antigen-binding portion thereof, which binds to an epitope of the p40 subunit of IL- 12 and/or IL-23 in the manufacture of a medicament for treating plaque psoriasis in a subject, wherein the medicament is to be administered subcutaneously to the subject to provide said antibody, or antigen-binding portion thereof, in an amount of about 100 mg to about 200 mg to the subject.