baber/WOPTO huggingface dataset:
Patent CA-2286293-C (CA)
Title: A method for extracting quantitative information relating to an influence on a cellular response
Inventor: ALMHOLT KASPER
IPC: G01N33/50
Filed: 1998-04-07
Granted: 2004-04-06
Abstract: Cells are generically modified to expresss a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Fluorescent Protein (GFP, EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent protein kinase, a cyclin-, calmodulin- or phospholipid-dependent or mitogen-activate d serine/threonin protein kinase, a tyrosine protein kinase, or a protein phosphatase (e.g. PKA, PKC, Erk, Smad, VASP, actin, p38, Jnk1, PKG , IkappaB, CDK2, Grk5, Zap70, p85, protein-tyrosine phosphatase 1C, Stat5, NEAT, NFkappaB, RhoA, PKB). An influence modulates th e intracellular signalling pathway in such a way that the luminophore is being redistributed or translocated with the component in living cells in a manner experimentally determined to be correlated to the degree of the influence. Measurement of redistribution is performed by recording of light intensity, fluorescence lifetime, polarization, wavelength shift, resonance energy transfer, or other properti es by an apparatus consisting of e.g. a fluorescence microscope and a CCD camera. Data stood as digital images are processed to numbers representing the degree of redistribution. The method can be used as a screening program for identifying a compound that modulates a component and is capable of treating adisease related to the function of the component.
Patent CA-2286914-C (CA)
Inventor: HIROTA HIROSHI
IPC: C07D211/60
Filed: 1998-03-31
Granted: 2005-07-26
Abstract: The present invention provides a highly safe and easily operable process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof in a high yield.      Described specifically, the present invention relates to a process for producing 1-clorocarbonyl-4-piperidinopiperidine or hydrochloride thereof, which comprises reacting 4-piperidinopiperidine with a trialkylsilyl halide to obtain a 4-piperidinopiperidinyl trialkylsilyl, reacting it with a carbon dioxide gas to obtain a 4-piperidinopiperidinyl trialkylsilyl carbamate derivative, reacting the derivative with thionyl chloride or the like to obtain 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and optionally treating it with a strong base.
Patent CA-2287611-C (CA)
Title: Digital signal processing apparatus
Inventor: KELLY PETER JOHN
IPC: H04B1/713
Filed: 1999-10-26
Granted: 2007-12-04
Abstract: A payload of a communications satellite includes several receive chains connected to respective antennas 1 to 4. Each receive chain 6 is hybrid in that analogue filtering is carried out at the front end in order to remove the unwanted input spectrum beyond that of a broadband within which a narrowband signal is frequency hopped. Thereafter the filtered signal is digitised and the hopping pattern removed by using successive segments of a control word which determines the hopping frequencies to successively select progressively narrower sub-bands which contain the wanted signal on each hop.
Patent CA-2287634-C (CA)
Inventor: WONG MICHAEL Y M
IPC: A61Q5/10
Filed: 1999-10-27
Granted: 2008-07-15
Abstract: The novel primary intermediate, 1-(5-amino-2-hydroxyphenyl) ethane--1,2-diol and a method for producing same, are disclosed. The novel intermediate can be employed as a replacement for p-aminophenol in oxidation dye formulations.
Patent CA-2298237-C (CA)
Inventor: JOHNSON KEVIN L
IPC: B60K17/10
Filed: 2000-02-07
Granted: 2004-11-09
Abstract: A variable displacement hydraulic pump includes a pump cylinder barrel having a plurality of axially arranged cylinder chambers disposed therein and each cylinder chamber includes a reciprocating piston therein. The pump is rotatably supported by the pump block and a motor block is separable from and connected to the pump block. A hydraulic motor is rotatably supported by the motor block and hydraulically connected to the pump through a pair of continuous passages formed in the pump and motor blocks. The motor includes an axis of rotation substantially perpendicular to an axis of rotation of the pump. A motor includes a cylinder barrel having a plurality of axially arranged cylinder chambers disposed therein and each cylinder chamber has a reciprocating piston therein. A thrust bearing is supported by a portion of the pump and motor block and is receivably engaged with the pistons extended from the cylinder barrel of the motor. A stop member is attached to the portion of the pump and motor block and in contact with the thrust bearing wherein relative movement of the thrust member is restrained by the stop member.
Patent CA-2300049-C (CA)
Title: Compositions, apparatus and methods for facilitating surgical procedures
Inventor: DUHAYLONGSOD FRANCIS G
IPC: A61M25/00
Filed: 1998-08-07
Granted: 2009-03-10
Abstract: Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient.  The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing is then selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageoulsy may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
Patent CA-2307036-C (CA)
Inventor: MILINKOVIC MIROSLAV
IPC: B01D53/00
Filed: 1998-11-03
Granted: 2003-05-27
Abstract: A closed loop, carbon monoxide self-contained preferably continuous process and apparatus for the production of nickel or nickel coated objects by nickel vapour deposition (NVD), comprising placing an object (34) to be treated with nickel carbonyl in a deposition chamber (28); feeding a gaseous mixture of nickel carbonyl and carbon monoxide to the chamber; producing the nickel or nickel coated object and a nickel carbonyl-depleted gaseous mixture; removing nickel carbonyl from the nickel carbonyl-depleted gaseous mixture in a primary (40) and subsequent secondary (48, 50) condensation unit and, preferably, a tertiary condensation unit to produce an essentially nickel carbonyl-free gas.  The secondary and tertiary (72, 74) condensation units operably freeze out and subsequently thaw nickel carbonyl and most preferably each comprises a pair of units linked in parallel arrangement operative in alternating, alternate freeze-thaw modes. Carbon monoxide-containing gas is recycled to a nickel carbonyl reactor (86).
Patent CA-2308045-C (CA)
Inventor: EMERY ROY WILLIAM
IPC: B65G15/58
Filed: 2000-05-31
Granted: 2001-08-28
Abstract: Lightweight moulded pulp trays or the like are attracted upward from transport on the upper side of a first conveyor to contact with the underside of the lower run of the perforated conveyor belt of a vacuum transfer mechanism by means of vacuum conditions transmitted through groups of perforations in said perforated belt, the location of said perforations in each group, and the timing of vacuum conditions transmitted through each perforation in each group being arranged to lift the forward and rearward proportions of each said product simultaneously with continuous support during transport to a selected location for simultaneous release of vacuum support for said forward and rearward portions of each said product, whereby to provide a level lift and drop-off for each product.
Patent CA-2318324-C (CA)
Inventor: HUMBERT MICHALON
IPC: G09F11/21
Filed: 1999-01-20
Granted: 2008-09-16
Abstract: The invention concerns a sequential display device for fixing individually, without being crumpled or torn or losing adhesive strength, several posters, directly on a polyester film support. A film support (1) moves past two display guides (4) and is wound inside and at the rear of storing rollers (2), their front surface facing the axis of said rollers. The posters (3) are directly fixed onto the support film with double-sided adhesives (5) as the film support is being wound. In storing phase, on the rollers, the poster perfectly matches the support film without being crumpled or torn. In display phase, between the display guides, the poster is properly stretched in front of the display window. The device is particularly designed for storing and displaying posters in sequential display poster panels.
Patent CA-2319201-C (CA)
Inventor: MAZHARY AHMAD M
IPC: A61P/
Filed: 1999-11-30
Granted: 2006-07-11
Abstract: Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising particulate celecoxib in an amount o f about mg to about 1000 mg in intimate mixture with one or more pharmaceutically acceptable excipients. The compositions are useful in treatment or prophylax is of cyclooxygenase-2 mediated conditions and disorders.
Patent CA-2319367-C (CA)
Inventor: WADA MASANORI
IPC: C04B35/486
Filed: 1999-11-18
Granted: 2005-04-05
Abstract: In order to provide a tubular or a rod-like ceramic article which is opaque to a visible light and which enables easy and efficient measurement and inspection of its internal structure, the tubular or the rod-like ceramic article opaque to a visible light is made of an infrared transmitting ceramics having a transmittance not less than 45% for an infrared ray having a wavelength of 1500nm and incident from the air when the thickness is equal to 1 mm.   Preferably, the ceramic article is made of an infrared transmitting ceramics which satisfies the condition given by (1-R)2 ~ 0.84 and µ ~ 0.7/mm where R represents a reflectance at 1550nm and µ represents a sum of a scattering coefficient and an absorption coefficient.
Patent CA-2323244-C (CA)
Title: Integrated machine control method and machine control module
Inventor: FAGERLUND JOHN
IPC: D21F7/00
Filed: 2000-10-12
Granted: 2008-01-08
Abstract: The invention relates to a method and apparatus for controlling a papermaking machine/board machine/tissue machine, which papermaking machine/board machine/tissue machine includes basic unit assembly groups, such as a headbox, a wire section, a press, a drying section, a coating unit, a finishing machine, etc.  The machine control system of the papermaking machine/board machine/tissue machine or such comprises a central processing unit, one or more process control units, and one or more input/output units, which are connected by control cables to the controlled units or actuators. In the method, the process control units and/or input/output units of the machine control system are located in a mechanical machine part in connection with basic unit assembly groups of the papermaking machine/board machine/tissue machine or such.
Patent CA-2323363-C (CA)
Title: Novel compositions of eprosartan
Inventor: VENKATESH GOPADI M
IPC: A61K31/44
Filed: 1999-03-11
Granted: 2008-09-30
Abstract: This invention relates to a novel composition comprising eprosartan, or a salt, solvate, or hydrate thereof, in particulate form, a process for its production and methods of using the composition to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.
Patent CA-2324108-C (CA)
Inventor: GO ANDREW
IPC: B27N3/04
Filed: 1999-03-16
Granted: 2008-05-27
Abstract: The present invention is concerned with a method for obtaining a wood panel, preferably an OSB panel, with significantly reduced thickness swelling properties when exposed to or contacted with moisture or water. The novel dimensionally stable panels are obtained by an alternate vacuum - steam injection method. The method is an after-fabrication, or post-treatment method, and involves one or more cycles of applying a vacuum followed by injection of hot steam in a sealed treatment chamber.
Patent CA-2324343-C (CA)
Inventor: DE LONG MITCHELL ANTHONY
IPC: A61K31/215
Filed: 1999-03-22
Granted: 2005-05-31
Abstract: L'invention se rapporte à de nouveaux analogues de prostaglandines, en particulier à des composés possédant une structure qui correspond à la formule suivante: (formule) R1, R2, R3, R4, R5, R6, W, X, Z, a, b et p étant définis dans la description de l'invention. L'invention concerne également des isomères optiques, des diastéréoisomères et des énantiomères correspondant à la formule ci-dessus ainsi que des sels pharmaceutiquement acceptables, des amides biohydrolisables, des esters et leurs imides. Les composés de la présente invention sont utilisés pour traiter toute une série de maladies et d'états tels que les troubles osseux et le glaucome, ainsi l'invention concerne-t-elle également des compositions pharmaceutiques comprenant ces composés. L'invention concerne en outre des traitements des troubles osseux et du glaucome au moyen de ces composés ou de compositions contenant ces derniers.
Patent CA-2340187-C (CA)
Title: Systems and methods for prerating costs for a communication event
Inventor: WALKER RICHARD J
IPC: H04M17/00
Filed: 1999-08-11
Granted: 2008-04-15
Abstract: Sytems and methods for prerating communication events, such as telephone calls, for prepaying customers are described. The systems and methods permit, at the beginning of a communication event, the determination of a time limit for the event based on the available balance in a prepayment account associated with the event.
Patent CA-2343339-C (CA)
Inventor: GUERRET OLIVIER
IPC: C08F4/00
Filed: 2001-04-06
Granted: 2005-08-09
Abstract: L'invention concerne un procédé de préparation d'un polymère multimodal p ar polymérisation radicalaire d'au moins un monomère en présence de plusieurs alcoxyamines comprenant l'enchaînement de formule <IMG> dans laquelle R L est un radical monovalent présentant une masse molaire supérieure à 15, A représente le coeur de l'alcoxyamine, n est un nombre entier non nul, lesdites alcoxyamines présentant des valeurs de n différents.
Patent CA-2344317-C (CA)
Title: Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke
Inventor: NAGAI NOBUO
IPC: A61K38/00
Filed: 1999-09-24
Granted: 2012-01-24
Abstract: The present invention relates to a new means for the treatment of focal ischemic cerebral infarction (ischemic stroke). It has been found that reduction of .alpha.2-antiplasmin leads to a significantly smaller focal cerebral infarct size. The invention therefore provides the use of compounds that reduce .alpha.2-antiplasmin concentration or activity in vivo, for the preparation of a therapeutical composition for the treatment of focal cerebral ischemic infarction (ischemic stroke).
Patent CA-2345652-C (CA)
Title: Composition pour revetement electrolytique cathodique
Inventor: OHRBOM WALTER
IPC: C09D133/14
Filed: 1999-11-30
Granted: 2007-11-20
Abstract: Cette invention a trait à des compositions de revêtement électrolytique cathodique possédant une résine carbamate fonctionnelle avec un site salifiant cationique, un agent de réticulation réagissant avec la résine carbamate fonctionnelle et un agent de durcissement carbonate. L'invention porte également sur des procédés d'électrodéposition par voie cathodique d'un revêtement sur un substrat à l'aide des compositions susmentionnées. Ces compositions, qui offrent des sites de réticulation de l'uréthanne sans que l'on ait à recourir à des isocyanates inhibés présentant des désavantages, permettent une prise à des températures inférieures à celles qu'exigent les compositions de revêtement électrolytiques cathodiques relevant des techniques existantes.
Patent CA-2346726-C (CA)
Title: Growth enhancers
Inventor: EVJU HANS
IPC: A23K3/03
Filed: 1999-10-12
Granted: 2009-09-08
Abstract: The present invention comprises an additive for compound feed for pigs, shee p, goats, poultry, cattle, horses, dogs, cats and fur-bearing animals, which contains an organic or inorganic acid, or salts thereof, espacially formic acid, with a beneficial effect on the treatment of compound feed, and a spent sulphite liquor from an acidic or neutral cellulo se sulphite cook. The additive contains the acid or salts thereof in an amount ranging from 10-90 percentage weight, and the spent sulphite liquor in an amount ranging from 10-90 percentage weight. The additive is added is added to the compound feed in an amount ranging fro m 0,2 to 3,0 %. The spent sulphite liquor can be adsorbed on a suitable carrier, such as soy meal or water-adsorbing silicates, in ord er to attain a dry composition.
Patent CA-2349059-C (CA)
Inventor: MORISHITA KAZUHIRO
IPC: H01L23/32
Filed: 2001-05-28
Granted: 2008-09-09
Abstract: An object is to suppress resonance phenomenon. A pair of reinforcing members (18) are fixed on a gate drive substrate (7) with spacers (37) interposed therebetween and upright portions (40) of the pair of reinforcing members (18) are fastened with screws on a side wall of a cathode flange. A spacer (118) is fixed on the gate drive substrate (7) and a projection (118a) of the spacer (118) is inserted in an engaging member (119) fixed on. the bottom of the cathode fin electrode (5) and thus fixed on the bottom of the cathode fin electrode (5). The pair of upright portions (40) as the first and second supporting points and the projection (118a) as the third supporting point stably support the gate drive substrate (7) on the cathode fin electrode (5) without freedom of rotation at the three positions arranged to surround an opening (49).
Patent CA-2351094-C (CA)
Inventor: LUPTON ELMER C
IPC: H04J3/00
Filed: 1999-06-09
Granted: 2011-05-03
Abstract: Communication network. The network includes a source of information in the form of a signal and a transmitter which emits light suitable for illumination comprising no applications unacceptable flicker and includes means for modulating the light with the information signal. The light passes through a medium to a receiver form receiving the light and demodulating the signal to obtain information. A user then uses the information.
Patent CA-2353982-C (CA)
Inventor: VAZQUEZ DENZIL COTERA
IPC: E21B43/18
Filed: 1999-11-19
Granted: 2009-04-07
Abstract: The invention describes improvements in the process of recovering hydrocarbons in oil wells by injection of treated inert gases of one or various industrial effluences comprising the steps of treating the industrial effluence(s) by operations appropriate to make the constituents and the parameters of the effluence compatible with the hydrocarbons of the deposit and regulating the distribution of different types of gases from their place of origin.
Patent CA-2356601-C (CA)
Inventor: LAGRAFF JOHN R
IPC: C23G1/00
Filed: 2001-09-06
Granted: 2010-05-11
Abstract: A liquid chemical stripping or cleaning solution is selected by combinatorial high throughput screening. A high throughput screening well array assembly (10) includes (A) a metal substrate and (B) a mask (16) that defines an array of wells on the substrate. A combinatorial high throughput screening system includes (A) a metal substrate and (B) a mask (16) that defines an array of wells on the substrate and a reaction vessel to receive the well array assembly (10).
Patent CA-2357184-C (CA)
Inventor: DUMKE ROBERT A
IPC: F16K31/00
Filed: 2001-09-12
Granted: 2006-08-08
Abstract: A valve assembly includes a valve body formed of a cylinder having upper and lower ends with an inlet port at one end, an outlet port on an opposite end and at least one side outlet port. An annular ring element has upper and lower ends on which are formed upper and lower valve seats, respectively, the ring being sealed around its periphery on each end to the valve body. A central portion of the ring connecting the upper and lower ends has at least one and preferably about 6 to 8 openings therethrough in fluid flow communication with the side outlet port.      An actuator assembly fitted in the cylinder includes actuators, concentrically fitted actuator rods valve stems and valve plugs for opening and closing the two valve ports by engaging the valve seats on opposite sides of the ring.      The rod for the upper valve seat is in the form of a hollow cylinder concentric and coaxial with the actuator rod for the lower seat, the first and second rods being independently actuatable. An independently controllable actuator assembly in the side outlet port includes a valve actuator, an actuator rod attached to and a valve plug for closing the outlet port. The outlet port, when open is in flow communication with a drain open to the atmosphere whereby liquids can be drained by gravity from the space between the annular ring and the cylinder when the side outlet is open.
Patent CA-2361591-C (CA)
Title: Dispositif de determination de la corrosion des engins broyants dans un broyeur rotatif
Inventor: BOULANGER LOUIS
IPC: B02C25/00
Filed: 2001-11-05
Granted: 2009-03-03
Abstract: Le broyeur comporte une virole cylindrique (10) tournant autour de son axe longitudinal et contenant une charge broyante constituée d'engins broyants en alliage métallique. Au moins un engin broyant (30) identique à  ceux formant la charge broyante est fixé sur un socle (28) en élastomère ou en caoutchouc, lui-même fixé sur la surface intérieure de la virole. Cet engin broyant (30) est exposé aux conditions régnant à l'intérieur du broyeur et est associé à une électrode de référence (36) dont il est isolé  électriquement. Cette électrode de référence (36) est protégée des chocs impacts de la charge dans le broyeur mais est en contact électrique avec la pulpe dans le broyeur, ledit engin broyant (30) et ladite électrode (36) étant reliés électriquement à un appareil de mesure (18) fixé à l'intérieur de la virole du broyeur.
Patent CA-2362794-C (CA)
Inventor: UHLMANN FRANK
IPC: A61P35/00
Filed: 2000-02-14
Granted: 2010-11-09
Abstract: Cette invention a trait à une technique d'identification de composés interférant avec une séparation de chromatides soeurs ou modulant celle-ci dans des cellules animales ou végétales, par modulation d'une protéase avec une activité cystéine endopeptidase de type séparine. Ces inhibiteurs de l'activité séparine se révèlent des plus utiles en thérapie anticancéreuse, aux fins de la prévention d'anomalies congénitales et aux fins de l'accroissement de la ploïdie chez les végétaux.