baber/WOPTO huggingface dataset:
Patent CA-3152173-A1 (CA)
Inventor: CUESTA MATEOS CARLOS
IPC: A61K31/519
Filed: 2020-10-09
Abstract: The present invention provides a novel use and methods comprising antibodies, or antigenbinding fragments thereof, which bind to a CCR7 receptor for use as a novel combination therapy with a BTK inhibitor and/or a Bcl-2 inhibitor in treatment of hyperproliferative blood malignancies, preferably in B-cell lymphomas, such as CLL. The combination can be used as first line, or in naïve patients not treated before with a BTK inhibitor and/or Bcl-2 inhibitor, or in patients with a BTK- inhibitor and/or Bcl-2-inhibior refractory/relapsed disease. The antibodies and antigen-binding fragments are capable of selectively depleting ex vivo or in vitro malignant cells expressing CCR7 and are capable of impairing/blocking migration of said tumor cells towards CCR7 ligands. These effects are not related to previous or contemporary treatments with a BTK inhibitor and/or a Bcl-2 inhibitor. Similarly, the efficacy of the antibodies is not affected in patients that have relapsed/refractory disease. The use of said antibodies as a monotherapy or as a combination with a BTK inhibitor and/or a Bcl-2 inhibitor for depleting, killing and impairing/blocking migration and activation of tumor cells expressing CCR7 cells is disclosed, thus providing an alternative therapy treating hyperproliferative blood cancers.
Patent CA-3152506-A1 (CA)
Inventor: CLASEN KEITH
IPC: F16L21/035
Filed: 2022-03-17
Abstract: A pipe connection in the form of a shrinkage connec-tion formed from a connecting piece (1) having a sur-face structure (11), and a pipe (2) having an inner diameter which is smaller than the outer diameter of the connecting piece (1), wherein the surface struc-ture (11) of the connecting piece (1) comprises at least one radially projecting flange (12) and at least one circumferential groove (13a, 13b,...), the pipe (2) comprises a pipe end (21) which has been expanded in environmental temperature and connected to the con-necting piece (1) by back-shrinkage. A sealing ring (3) is provided in the circumferential groove (13a, 13b,...), which sealing ring (3) has an annular profile having an inner surface (31), being engageable with a connecting piece (1) , and an outer surface (32), be-ing engageable with the pipe (2), and the outer sur-face (32) comprises more than one annular ridge (33a, 33b,..) adjacent to each other in axial direction.
Patent CA-3161428-A1 (CA)
Title: Appareil et procede permettant de separer un fluide de travail d'un absorbant
Inventor: ASAMOAH-BARNIEH RAYMOND
IPC: B01D61/00
Filed: 2019-11-22
Abstract: La présente invention concerne des améliorations apportées à des technologies permettant de séparer un fluide de travail d'un absorbant, tel que dans des pompes à chaleur à absorption. Un système basé sur l'absorption peut être mis en uvre dans un ou plusieurs cycles thermodynamiques qui utilisent une ou plusieurs barrières semi-perméables et des technologies associées pour régénérer de manière continue une solution de travail et un absorbant plutôt que de se baser uniquement sur un générateur entraîné thermiquement pour la fonction de régénération. Dans un aspect, le système utilise une technique de solubilité différentielle pour la régénération dans laquelle un dispositif séparateur présente une barrière semi-perméable et reçoit une solution contenant un fluide de travail absorbé dans un absorbant. Une substance réduisant la solubilité est mélangée à la solution dans le séparateur. La substance réduit la solubilité du fluide de travail dans l'absorbant pour séparer les deux. L'absorbant est perméable à la barrière semi-perméable tandis que la substance réduisant la solubilité ne l'est pas, ce qui permet à l'absorbant de s'écouler hors du séparateur tandis que la substance est retenue à l'intérieur de celui-ci.
Patent CA-3163873-A1 (CA)
Inventor: BEAUPRE RICHARD
IPC: B01D29/085
Filed: 2020-12-03
Abstract: L'invention concerne des ensembles récepteurs de lavage à contre-courant à décantation, et des procédés de fabrication et d'utilisation associés. La présente invention concerne des ensembles récepteurs de lavage à contre-courant à décantation améliorés pour la décantation de charges d'entrée, et des systèmes/procédés améliorés pour utiliser et fabriquer les ensembles récepteurs de lavage à contre-courant à décantation. La présente invention concerne des ensembles récepteurs de lavage à contre-courant à décantation utilisant des éléments d'insert de support poreux et/ou des surfaces de support poreux pour la décantation de charges d'entrée. Des exemples d'ensembles récepteurs de lavage à contre-courant à décantation sont configurés et dimensionnés pour recevoir un écoulement de liquide de lavage à contre-courant de filtre de suspension (par exemple, des solides et un mélange liquide), et permettent la sédimentation des solides à partir de l'écoulement 11, et assurent la décantation d'une couche de liquide au-dessus des solides décantés, et permettent éventuellement de démouiller les solides décantés, et de fournir une décharge des solides décantés (par exemple, un liquide mouillé) à partir du fond des ensembles.
Patent CA-3164254-A1 (CA)
Title: Marina system with a hydroelectric power plant, and a pump module
Inventor: SADIGHI JAKOB
IPC: F03B13/18
Filed: 2020-12-08
Abstract: The invention relates to a marina system comprising at least one berth (13) for boats, at least one lock chamber (14, 14a) with two lock gates (15, 15a; 16, 16a) each, and a hydroelectric power plant (1) for supplying water to the marina system. The hydroelectric power plant (1) has at least one pump module (2) which is driven by wave movements of a sea section (M). According to the invention, a pump module (2) is also provided.
Patent CA-3164405-A1 (CA)
Title: Systeme de commande de porte
Inventor: ELIASSON DANIEL
IPC: E05F15/684
Filed: 2020-12-15
Abstract: La présente invention concerne un système de commande (1) de porte permettant d'ouvrir et de fermer une ouverture (2), comprenant un cadre (3) de porte comportant une première section (4) de cadre sur un premier côté (7) de l'ouverture (2) et une seconde section (6) de cadre sur un second côté (5) de l'ouverture (2). Le système de commande comprend en outre une porte (8) agencée pour être déplacée entre une position ouverte et une position fermée (C), la porte (8) étant reliée de façon mobile au cadre (3) de porte et une unité d'entraînement (10) montée sur la porte (8), l'unité d'entraînement (10) comprenant au moins un moteur (11) agencé pour déplacer la porte (8) de la position fermée (C) vers la position ouverte (O). Un élément (19) de transmission allongé s'étend le long du premier côté (7) de l'ouverture (2) et de la première section (4) de cadre. L'unité d'entraînement (10) comprend en outre un élément de transmission (18) entraîné en liaison d'entraînement avec le moteur (11).
Patent CA-3165210-A1 (CA)
Inventor: PEAN GREGOIRE
IPC: H04W24/06
Filed: 2021-01-19
Abstract: In various embodiments, a network emulation application emulates network conditions when testing a software application. In response to a request to emulate a first set of network conditions for a first client device that is executing the software application, causing a kernel to implement a first pipeline and to automatically input network traffic associated with the first client device to the first pipeline instead of a default bridge. In response to a request to emulate a second set of network conditions for a second client device that is executing the software application, causing the kernel to implement a second pipeline and to automatically input network traffic associated with the second client device to the second pipeline instead of the default bridge. Each of the pipelines perform one or more traffic shaping operations on at least a subset of the network traffic input into the pipeline.
Patent CA-3166250-A1 (CA)
Inventor: PLUCINSKI GREGORY G
IPC: A61K9/00
Filed: 2021-02-05
Abstract: L'invention concerne des produits médicamenteux conçus pour être administrés par voie nasale comprenant un dispositif et une composition pharmaceutique comprenant un antagoniste de récepteurs opioïdes ou des doses unitaires de celui-ci, des compositions pharmaceutiques comprenant un antagoniste de récepteurs opioïdes et des procédés d'utilisation et de préparation associés.
Patent CA-3166427-A1 (CA)
Inventor: MARSHALL EVAN JAMES
IPC: G06F7/00
Filed: 2020-12-30
Abstract: A system and method of generating a professional report. The method includes selecting a report subject matter, tagging the report subject matter, providing report suggestions based on the report subject matter and a scoring subprocess, and selecting library content. The method then includes creating a draft report using the selected library content, editing the draft report, submitting the draft report for review, and providing a finalized report.
Patent CA-3166646-A1 (CA)
Title: Procede et entrepot de preparation de commandes pour entreposer et preparer des commandes de marchandises
Inventor: FORSTER FLORIAN
IPC: B65G1/137
Filed: 2021-01-12
Abstract: L'invention concerne une méthode pour l'entreposage et le ramassage de transporteurs d'articles empilables (3) dans un entrepôt de traitement de commandes, où des dispositifs d'aide au chargement pour le transport (7a, 7b, 7c) sont transportés entre un point de chargement doté d'un dispositif de chargement opéré de façon automatique (10), une zone d'entreposage (5) et un point de déchargement doté d'un dispositif de déchargement opéré de façon automatique (11) au moyen de véhicules de transport sans conducteur (9) se déplaçant de manière autonome. Des transporteurs d'articles empilables sont chargés à l'aide de groupes d'aide au chargement pour le transport (8a, 8b, 8c) au poste de chargement, et les transporteurs d'articles empilables sont déchargés des dispositifs d'aide au chargement pour le transport au poste de déchargement. Par la suite, les transporteurs d'articles requis pour le ramassage d'une commande sont chargés de nouveau sur un ou plusieurs dispositifs d'aide au chargement cibles (70; 170). L'invention concerne également un entrepôt de ramassage pour l'entreposage et le ramassage de transporteurs d'articles empilables.
Patent CA-3167184-A1 (CA)
Inventor: THAI LINH
IPC: A63F9/24
Filed: 2021-02-26
Abstract: The present disclosure generally relates to an automated gaming arrangement, specifically provided with means for reducing the need of continuous human surveillance. The present disclosure also relates to a corresponding method for operating such a gaming arrangement and a thereto related computer program product.
Patent CA-3173556-A1 (CA)
Inventor: MCALLISTER KEVIN
IPC: B60D1/06
Filed: 2016-03-07
Abstract: A ball assembly for attachment to a ball mount is described. The ball assembly can include a ball post that is securable to a ball mount. A hitch ball is slidably coupled to the ball post at a ball end of the ball post. A load gauge is disposed at the gauge end of the ball post. A load transfer element is operably associated with both the hitch ball and the load gauge so as to cause a load measurement to display on the load gauge based upon a load applied to the hitch ball.
Patent CA-3176749-A1 (CA)
Inventor: NIELSEN POUL
IPC: C07D473/02
Filed: 2021-04-29
Abstract: L'invention concerne des composés de formule (1) comprenant un squelette de pleuromutiline avec un groupe latéral à base de triazole en C22. Les composés peuvent être utilisés pour le traitement d'infections bactériennes et d'infections fongiques. Il est important de noter que les infections provoquées par des bactéries multirésistantes aux médicaments, telles que staphylococcus aureus résistant à la méthicilline (MRSA), peuvent être traitées efficacement.
Patent CA-3177717-A1 (CA)
Title: Compositions and methods for treating cancer
Inventor: LUO PETER PEIZHI
IPC: A61K39/395
Filed: 2021-05-13
Abstract: The present application provides compositions and methods for treating cancers, including follicular lymphoma, T cell lymphoma and adenoid cystic carcinoma, using an anti-CD137 antibody that specifically binds to an extracellular domain of human CD137. In some embodiment, combination therapies including the anti-CD137 antibody and an immune checkpoint inhibitor, and/or a chemotherapeutic agent are provided. Biomarkers such as total CD137, membrane bound CD137 (mCD137), soluble CD137 (sCD137), CD137 ligand, Ki67, CD8+ effector memory T (Tem) cells, regulatory T (Treg) cells, and natural killer (NK) cell levels for the methods of treatment described herein are also provided.
Patent CA-3178872-A1 (CA)
Title: Melanges synergiques de gabapentine et de ketoprofene, compositions pharmaceutiques et leur utilisation medicale
Inventor: ARAMINI ANDREA
IPC: A61K31/192
Filed: 2021-04-21
Abstract: La présente invention concerne un mélange synergique de gabapentine et de kétoprofène, de préférence la kétoprofène lysine, une composition pharmaceutique comprenant lesdits mélanges et l'utilisation desdits mélanges ou desdites compositions pharmaceutiques dans le traitement de la douleur aiguë ou chronique, en particulier dans le traitement de la douleur neuropathique ou inflammatoire.
Patent CA-3179909-A1 (CA)
Title: Cortical rim-supporting interbody device
Inventor: COHN WILLIAM
IPC: A61F2/30
Filed: 2021-04-07
Abstract: An inflatable central distractor is inserted in to a disc space between two vertebral endplates. A perimeter balloon is inserted into the disc space in such a manner as to surround the central inflatable distractor. The perimeter balloon and the central inflatable distractor are simultaneously expanded such that as the central inflatable distractor expands the perimeter balloon surrounds the central inflatable distractor and such that the central inflatable distractor and the perimeter balloon, when expanded, contribute to forcing adjacent vertebral endplates apart.
Patent CA-3181113-A1 (CA)
Title: Composition de soins personnels a base d'oxyde de titane et d'un polymere reticule d'acide adipique et de neopentylglycol
Inventor: WANG LIN
IPC: A61K8/29
Filed: 2021-05-21
Abstract: La présente invention concerne une composition de soins personnels. En particulier, la présente invention concerne une composition de soins personnels pour traiter le teint brouillé. La présente invention concerne une composition de soins personnels comprenant : a) du dioxyde de titane ; et b) 8 à 60 % en poids d'un polymère réticulé comprenant de l'acide adipique et du néopentylglycol.
Patent CA-3183053-A1 (CA)
Inventor: AGUIRRE AITOR
IPC: A61K35/12
Filed: 2021-06-17
Abstract: A method for generating a heart organoid is provided. The method includes forming a cellular aggregate of pluripotent stem cells, activating Wnt signaling in the cellular aggregate to cause the cellular aggregate to differentiate into a three-dimensional cardiac mesoderm, and inhibiting the Wnt signaling in the cardiac mesoderm to form the heart organoid. The heart organoid includes myocardial tissue, endocardial tissue defining at least one chamber, and epicardial tissue disposed on at least an outer surface of the myocardial tissue. The heart organoid beats. Heart organoids prepared in accordance with the method are also provided.
Patent CA-3187726-A1 (CA)
Inventor: SHAVIT MENACHEM
IPC: A61J1/18
Filed: 2015-08-10
Abstract: The present technology discloses a cost-effective, single use bag or container for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, 02, CO2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.
Patent CA-3190221-A1 (CA)
Title: Conditioning agent for a particulate fertilizer
Inventor: NAFISI VAJIHEH
IPC: C05G3/20
Filed: 2021-08-23
Abstract: The present disclosure is related to a conditioning agent for reducing water absorption and dust formation of a particulate fertilizer, comprising 50 to 60 weight% of wax, 30 to 40 weight% of oil, 1 to 15 weight% of a resin being oil-soluble and miscible with wax and oil, and optionally 0.01 to 2.0 weight% of a viscoelastic elastomer which is soluble in oil. The conditioning agent may be applied to a particulate substrate, in particular a fertilizer particulate substrate, to reduce the moisture uptake and the dust formation of the substrate, in particular wherein the substrate is blended with other particulate compositions.
Patent CA-3194488-A1 (CA)
Inventor: LEE SHWN-JI S H
IPC: C07F9/6558
Filed: 2021-10-04
Abstract: Improved methods for the production of nickel (II) etioporphyrin-l. The improved method for the production of nickel (ll) etioporphyrin-l comprises brominating kryptopyrrole to provide monobromo-dipyrromethene, wherein the bromination is carried out in the presence of ethyl acetate; (b) cyclizing monobromo-dipyrromethene to provide etioporphyrin-l; and metallating etioporphyrin-l with a nickel (II) salt to provide nickel (II) etioporphyrin-l.
Patent CA-3195272-A1 (CA)
Title: Triazine derivative having virus propagation inhibitory effect, and pharmaceutical composition containing same
Inventor: TACHIBANA YUKI
IPC: A61P43/00
Filed: 2022-02-17
Abstract: The present invention provides a compound exhibiting a coronavirus 3CL protease inhibitory effect and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing the same. Further provided are crystals that are useful as a drug substance, and a pharmaceutical composition containing the same. The compound represented by formula (1) or pharmaceutically acceptable salts thereof.
Patent CA-3196792-A1 (CA)
Title: Form wound motor for electrical submersible pumps
Inventor: MANSIR HASSAN
IPC: H02K15/06
Filed: 2022-02-21
Abstract: Disclosed is an apparatus According to the present invention, a new winding arrangement was developed to enhance the manufacturability of stators with large length to diameter ratio and small aperture diameters such as the ones designed and manufactured for downhole pumping applications. The rectangular conductors are pre-formed to a specific shape, nested together, and inserted into the stator slots. Once the conductors are inserted, additional bending and joining operations are required to complete the coils and phases. These operations can be either fully automatic or semi-automatic. The structure of the winding allows insertion of phase and phase to phase insulation after the joining operation is completed thus reducing the risk of damage to the insulation system during the joining process. The pre-formed winding due to its ability to nest by design results is very short end-turns compared to conventional winding.
Patent CA-3198123-A1 (CA)
Title: Blue-emitting phosphors and methods of use thereof
Inventor: BRGOCH JAKOAH
IPC: H01L33/50
Filed: 2021-11-19
Abstract: Provided herein are phosphors of the general molecular formula: (A2-2xEux)(Mg1-yCay)PO4F wherein the variables are as defined herein. Methods of producing the phosphors are also provided. In some aspects, the present disclosure provides light-emitting devices comprising these phosphors.
Patent CA-3200031-A1 (CA)
Inventor: FLYNN DANIEL L
IPC: A61K31/706
Filed: 2021-11-24
Abstract: La présente invention concerne, en partie, des méthodes de traitement d'infections virales, telles que des infections à coronavirus, chez des patients dont l'état le nécessite, comprenant l'administration auxdits patients d'un inhibiteur de VPS34.
Patent CA-3201583-A1 (CA)
Inventor: KASKIALA TONI
IPC: B42D25/324
Filed: 2021-12-20
Abstract: 17 A SECURITY ASSEMBLY AND METHOD FOR MANUFACTURING THE SAME ABSTRACT A security assembly 10 includes at least one substrate element 11, 120, 130, 140 at least one first pattern 121, 131; 22 and at least one second pattern 14; 24. The at 5 least one first pattern is associated with the at least one substrate element. The at least one first pattern is at least in part translucent or transparent. The at least one second pattern is associated with the at least one substrate element. Each of the at least one first pattern overlaps at least in part the at least one second pattern. Upon viewing the assembly, the at least one first pattern 22 and the at least one second pattern 24 are 10 configured to generate, at at least one side of the assembly, at least one third pattern 26, each of the at least one third pattern including an optically variable image. Figure 1
Patent CA-3205546-A1 (CA)
Inventor: ANGELETTI PIERO
Filed: 2023-07-04
Abstract: This application relates to a method of transforming input signals received at N input signal ports to output signals for output at M output signal ports. The method includes generating, from the input signals, first intermediate signals for processing by a fast Fourier transform, FFT, with a predefined number of input ports and output ports corresponding to a size of the FFT; applying the FFT to the first intermediate signals to obtain second intermediate signals; and generating the output signals from the second intermediate signals. The input signal ports are nen-uniformly distributed with respect to the input ports in a first signal domain of the input ports; and/or the output signal ports are non-uniformly distributed with respect to the output ports in a second signal domain of the output ports. The application further relates to beamforming networks, reconfigurability in beamforming and beam steering, wideband and narrowband multi beam antenna array devices, FFT processors, programs, and storage media.
Patent CA-3205639-A1 (CA)
Inventor: OGLAZA JEAN-FRANCOIS
IPC: A61B17/70
Filed: 2021-01-27
Abstract: Implant pour restaurer la hauteur d'un corps vertébral. L'implant comprend des plaques supérieure et inférieure configurées pour être écartées l'une de l'autre dans la direction cranio-caudale pour l'implant à déployer. Des supports sont couplés à la plaque supérieure et à une partie d'extrémité distale et agencés selon une configuration entrecroisée dans la direction proximale-distale dans une configuration d'insertion et une configuration déployée. La configuration entrecroisée facilite l'expansion accrue de l'implant. Les supports peuvent être latéralement espacés les uns des autres afin de définir un espace vide pour recevoir un élément de retenue et des surfaces arquées interne et externe peuvent fournir un profil généralement cylindrique à l'implant. L'un des supports peut être une fourche de support disposée dans une configuration en forme de V. Une longueur des supports peut correspondre à environ 50 à 90 % de la longueur des plaques supérieure et inférieure. L'implant peut être formé par fabrication additive.