Patent SG-11201903305X-A (SG)
Title: Substituted 6-(1h-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
Inventor: GIESE ANJA
IPC: A61K31/5377
Filed: 2017-10-09
Abstract: Oco O O () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WIPO I PCT (51) International Patent Classification: CO7D 403/14 (2006.01) A61K 31/506 (2006.01) CO7D 471/04 (2006.01) A61K 31/5377 (2006.01) C07D 487/04 (2006.01) A61P 13/12 (2006.01) CO7D 413/14 (2006.01) (21) International Application Number: PCT/EP2017/075630 (22) International Filing Date: 09 October 2017 (09.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16193953.3 14 October 2016 (14.10.2016) EP (71) Applicants: BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1, 51373 Leverkusen (DE). BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). (72) Inventors: GIESE, Anja; Horst-Kohl StraBe 15a, 12157 Berlin (DE). KLAR, Jurgen; Leipziger StraBe 6, 42109 Wuppertal (DE). EHRMANN, Alexander; Am Hausberg 2, 45219 Essen (DE). WILLWACHER, Jens; In den Birken 32, 42113 Wuppertal (DE). ENGEL, David; Schone Aussicht 15, 42369 Wuppertal (DE). DIESKAU, An- dre Philippe; Dr.-Tigges-Weg 19, 42115 Wuppertal (DE). KAHNERT, Antje; Paul-Ehrlich-Str. 10, 42113 Wup- pertal (DE). GROMOV, Alexey; Fuhlrottstr. 9, 40699 Erkrath (DE). SCHMECK, Carsten; Carl-Friedrich-Go- erdeler-StraBe 24, 45472 Millheim (DE). LINDNER, Niels; Bodelschwinghweg 4, 42115 Wuppertal (DE). MULLER, Thomas; Parkstr. 24, 40764 Langenfeld (DE). AN- DREEVSKI, Anna Lena; Altenhofer StraBe 123, 42719 Solingen (DE). DREHER, Jan; Ottenbrucher Str. 24, 42105 Wuppertal (DE). COLLINS, Karl; Fiirstenwall 135, 40215 Diisseldorf (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: — with international search report (Art. 21(3)) (54) Title: SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF (57) : The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing phar- maceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients. olimion °nolo omoionolomommio oimIE (10) International Publication Number WO 2018/069222 Al