baber/WOPTO huggingface dataset:
Patent DE-60025008-T2 (DE)
Inventor: CUTTITTA FRANK
IPC: A61K38/17
Filed: 2000-09-08
Granted: 2006-09-14
Abstract: The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM/factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents.
Patent DE-60025480-T2 (DE)
Inventor: GEORGES ELIAS
IPC: G01N33/566
Filed: 2000-05-12
Granted: 2006-08-24
Abstract: The invention relates to protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction. Using overlapping hexapeptides that encode for the entire amino acid sequences of the linker domains of human P-glycoprotein gene 1 and 3 (HP-gp1 and HP-gp3), a direct and specific binding between HP-gp1 and 3 linker domains and intracellular proteins was demonstrated. Three different stretches (<SUP>617</SUP>EKGIYFKLVTM<SUP>627</SUP>, (SEQ ID NO: 1) <SUP>658</SUP>SRSSLIRKRSTRRSVRGSQA<SUP>677 </SUP>(SEQ ID NO: 2) and <SUP>694</SUP>PVSFWRIMKLNLT<SUP>706 </SUP>(SEQ ID NO: 3) for HP-gp1 and <SUP>618</SUP>LMKKEGVYFKLVNM<SUP>631 </SUP>(SEQ ID NO: 4), <SUP>648</SUP>KAATRMAPNGWKSRLFRHSTQKNLKNS<SUP>674 </SUP>(SEQ ID NO: 5), and <SUP>695</SUP>PVSFLKVLKLNKT<SUP>707 </SUP>(SEQ ID NO: 6) for HP-gp3) in linker domains bound to proteins with apparent molecular masses of ~80 kDa, 57 kDa and 30 kDa. The binding of the 57 kDa protein was further characterized. Purification and partial N-terminal amino acid sequencing of the 57 kDa protein showed that it encodes the N-terminal amino acids of alpha and beta-tubulins. The method of the present invention was further validated with Annexin. The present invention thus demonstrates a novel concept whereby the interactions between two proteins are mediated by strings of few amino acids with high and repulsive binding energies, enabling the identification of high affinity binding sites between any interacting proteins.
Patent DE-60030868-T2 (DE)
Inventor: ANNO KOJI
IPC: A61L9/015
Filed: 2000-07-04
Granted: 2007-05-03
Abstract: An air cleaning device (A) includes a bulb-shaped casing (1) provided at one end with a base (4) and at the other end with an outlet (3e, 3a), in which an AC/DC converter (11) for converting an alternating current from the base (4) into a direct current, a boosting transformer (12) for boosting the direct current, and a negative ion generator or ozone generator (21 or 21A) connected to the boosting transformer (12) are accommodated. Application of high voltage from the boosting transformer (12) to the negative ion generator or ozone generator (21 or 21A) induces electrical discharge to generate negative ions alone or both negative ions and ozone and release the negative ions alone or both the negative ions and the ozone from the outlet (3e, 3a). The device can be disposed on the floor, suspended from above, hung on the wall or set in position at an optional location, using as its power source electric power from a socket (41A, 41B) for a reading lamp, a socket (62) built in the ceiling, or an electrical receptacle mounted in a wall, so that negative ions alone or both negative ions and ozone can be released in an optional direction. <IMAGE>
Patent DE-60032635-T2 (DE)
Inventor: HJELM SVEN
IPC: G01M99/00
Filed: 2000-12-19
Granted: 2007-10-04
Abstract: On a machine tool (1) in which a first element (2) intended to support a machining tool and a second element (3) intended to support a workpiece, are mutually movable, a special test arrangement (6) may be placed between the first element (2) and the second element (3). During a mutual displacement between the first and second elements, this test arrangement (6) can apply a predetermined force between these elements while at the same time making it possible to record the resulting shift between them. The measured results may be used for analysis of the machine's condition.
Patent DE-60034456-T2 (DE)
Inventor: KASAHARA SACHIO
IPC: G04B19/06
Filed: 2000-08-23
Granted: 2008-01-03
Abstract: A display plate original includes a supporting portion having a positioning structure formed to be positioned by engagement with another member, a display plate shape portion formed to have a predetermined positional relation to the positioning structure and have the planar shape of a display plate to be manufactured, and a connecting portion for connecting the display plate shape portion and the supporting portion, which are integrally provided, wherein an ink-receiving layer is formed on the surface of the display plate shape portion, for holding the received ink droplets thereby. <IMAGE>
Patent DE-60036641-T2 (DE)
Inventor: FERRARI EUGENIO
IPC: C12R1/08
Filed: 2000-12-21
Granted: 2008-07-03
Abstract: The present invention provides a mutant aprE promoter and methods for the production of a desired protein in a Bacillus host cell, which comprises the mutant aprE promoter. The present invention provides the sequence of a preferred aprE mutant promoter, which provided for a 100-fold increase in the production of a protein from Bacillus subtilis.
Patent DE-60102774-T2 (DE)
Inventor: CHEUNG NELSON
IPC: B65B13/18
Filed: 2001-10-03
Granted: 2005-03-24
Abstract: A hand strapping tool (210) has a lower gripper member (228) which comprises an upstanding or upwardly projecting lip portion (252) which is integrally formed upon the upper surface portion of the lower gripper member (228) at an elevational level above the upper crest portions of lower gripper member teeth (248) so as to define a space between the upwardly projecting teeth (248) of the lower gripper member (228) and the undersurface portion of the lower end portion of the overlapped end portions (216) of the strapping material (214) when an upper tensioning wheel (230) is retracted away from its engaged position with the lower gripper member (228). In this manner, the hand strapping tool (210), can be readily released from its engaged position with the article being strapped as well as with respect to the overlapped end portions (216,218) of the strapping material (214). Should the lip portion (252) of the lower gripper member (228) become eroded or worn, the lower gripper member (228) can be removed and replaced as a result of a friction fit mounting within the base member of the hand strapping tool (210).
Patent DE-60103037-T2 (DE)
Inventor: ANDERSEN STRAND
IPC: G05B17/02
Filed: 2001-03-12
Granted: 2005-04-28
Abstract: The invention relates to a control system, especially one for use in the control of industrial plant such as a polymerisation reactor. In particular, the invention provides a method of controlling a process comprising the steps of: a) generating a first-principle model corresponding to the process; b) inputting data describing the current and desired future process conditions; c) generating a linear approximation to the model which is valid for said current conditions; d) using said linear approximation to determine an approximate solution to a control problem related to the process; and e) controlling the process using said approximate solution.
Patent DE-60104440-T2 (DE)
Inventor: CERDAN MARTIN TOMAS
IPC: A47G29/10
Filed: 2001-03-28
Granted: 2005-07-28
Abstract: An improved key holder consisting of a case (1) provided with a central body (2), having in its upper part a semicircular area (3) and a lower curved one (4), the body (2) having on one of its faces, a longitudinal groove (6) dividing in two similar areas, having a projection (7) located in the blind face, incorporating a central recess and a longitudinal projection (8) in the groove (6), being covered with a body (10). <IMAGE>
Patent DE-60106871-T2 (DE)
Inventor: OTTESTAD TERJE
IPC: F16K31/126
Filed: 2001-01-05
Granted: 2005-12-01
Abstract: A pressure regulating valve for controlling an upstream fluid pressure in relation to a reference pressure by regulating the fluid quantity let through the valve, comprising a housing (1) having an upstream inlet (2) and a downstream outlet (3) for the fluid, a pressure-sensitive element (5) for sensing the pressure difference between the upstream pressure and the reference pressure, and a spring-loaded regulating piston (7) which, in cooperation with a seat (8), is arranged to regulate a flow passage (9) between the inlet (2) and the outlet (3), the piston (7) being operatively connected to the pressure-sensitive element (5), to change its position relative to the seat (8) in accordance with the position of the pressure-sensitive element (5). The regulating piston (7) is slidably arranged on the outside of a guide sleeve (10) having openings (11) for the flow of fluid from the flow passage (9) to the outlet (3). Further, the valve comprises a chamber (15) defined between an end surface (13) of the guide sleeve (10) and an inner end surface (14) of the piston (7), and a pilot body (16) which is mechanically coupled to the pressure-sensitive element (5) and is arranged to open ducts (20-23) for supply of fluid from the inlet (2) to the chamber (15) or delivery of fluid from the chamber (15) to the outlet (3) dependent on the position of the pilot body (16) relative to the regulating piston (7), so that the piston changes its position dependent on the chamber volume and thereby in accurate correspondence with the position of the pressure-sensitive element (5).
Patent DE-60107203-T2 (DE)
Inventor: COFFIN STUART
IPC: A61K35/763
Filed: 2001-01-22
Granted: 2005-12-01
Abstract: The present invention relates to the use of a modified, oncolytic, herpes simplex virus (HSV) strain in the manufacture of a medicament for the oncolytic treatment of cancer, which HSV strain: 
(a) has a greater ability than HSV1 17+, HSV1 F and HSV1 KOS strains with equivalent modifications to replicate in or kill tumour cells; and 
(b) is obtainable by isolating an HSV strain from a host and modifying the isolated HSV strain to provide for selective replication in tumour cells.
Patent DE-60113254-T2 (DE)
Inventor: HOROWITZ A
IPC: H04B3/32
Filed: 2001-06-13
Granted: 2006-01-19
Abstract: A first integrated circuit is coupled to a first connector. A second connector is coupled to the first connector through multiple conductors, in which alternating pairs of conductors are reversed. A second integrated circuit is coupled to the second connector through a second group of conductors. The first integrated circuit includes multiple differential drivers and the second integrated circuit includes multiple differential receivers. The inductive coupling coefficient of the first device is modified to be substantially the same as the inductive coupling coefficient of the second device.
Patent DE-60115691-T2 (DE)
Inventor: EVERAERTS I
IPC: C09J7/38
Filed: 2001-02-26
Granted: 2006-07-13
Abstract: Methods of applying a pressure sensitive adhesive to a substrate and adhering substrates together that includes applying a latent, over-tackified, adhesive to a substrate and applying a plasticizing agent to activate the latent, over-tackified, adhesive to form a pressure sensitive adhesive.
Patent DE-60117793-T2 (DE)
Inventor: DAVID DANIEL
IPC: A61B5/0205
Filed: 2001-05-18
Granted: 2006-10-12
Abstract: A medical examination chair includes a group of sensors including electrodes in finger-tip sensors, various other types of sensors incorporated in straps for the patient in the chair and load cells supporting the chair, all of which provide data which is partially processed in the electronics mounted in the chair and then transmitted to central station for patient diagnosis.
Patent DE-60120818-T2 (DE)
Inventor: ITOH YASUMASA
IPC: A61L2/24
Filed: 2001-04-03
Granted: 2007-06-28
Abstract: A device for gasifying a sterilizing liquid comprises a hot air duct having an inlet at one end thereof and an outlet at the other end thereof, a hot air generator for supplying to the inlet hot air having a temperature capable of gasifying the sterilizing liquid, a spray nozzle for spraying the sterilizing liquid into the hot air duct, and a plate heater disposed as opposed to the outlet. <IMAGE>
Patent DE-60121331-T2 (DE)
Inventor: HUETING J
IPC: H01L29/10
Filed: 2001-05-01
Granted: 2007-08-02
Abstract: A semiconductor body has source and drain regions (4 and 5) spaced apart by a body region (6) and both meeting a surface (3a) of the semiconductor body. A gate structure (7) is provided within a trench (8) for controlling a conduction channel in a conduction channel accommodation portion (60) of the body region (6) extending along at least side walls (8a) of the trench (8) and between the source and drain regions (4 and 5). A voltage-sustaining zone (600) consisting of first regions (6) of the same conductivity type as the source and drain regions interposed with second regions (62) of the opposite conductivity type is provided such that the first regions (61) provide a path for majority charge carriers to the drain region (5) when the device is conducting. The dopant concentrations and dimensions of the first and second regions (61 and 62) are such that, when the voltage-sustaining zone is depleted of free charge carriers in one mode of operation, the space charge per unit area in the first and second regions (61 and 62) balances at least to the extent that the electric field resulting from the space charge is less than the critical field strength at which avalanche breakdown would occur.
Patent DE-60121733-T2 (DE)
Inventor: ZARDI L
IPC: C07K16/24
Filed: 2001-02-22
Granted: 2007-08-09
Abstract: Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related macular degeneration, and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin ED-B. The biocidal or cytotoxic molecule may be interleukin-2 (IL-2), doxorubicin, interleukin-12 (IL-12), Interferon-³ (IFN-³), Tumor Necrosis Factor ± (TNF±) or Tissue Factor protein (which may be truncated).
Patent DE-60121802-T2 (DE)
Inventor: ANDERSSON ANDREAS
IPC: H04W4/06
Filed: 2001-12-28
Granted: 2007-08-02
Abstract: The present invention relates to cellular mobile radio system, and more especially it relates to Code Division Multiple Access, CDMA, cellular mobile radio systems, particularly to handover of a downlink shared or common channel in such systems. A method and system for hard handover of a shared channel within a dynamic Active Set is proposed.
Patent DE-60122345-T2 (DE)
Inventor: PETKOVIC HRVOJE
IPC: C07D313/00
Filed: 2001-08-14
Granted: 2007-08-30
Abstract: Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
Patent DE-60128016-T2 (DE)
Inventor: SATOKAWA SHIGEO
IPC: B01D53/04
Filed: 2001-01-30
Granted: 2007-12-27
Abstract: An adsorbent for removing sulfur compounds from sulfur-compounds-containing fuel gas comprises a zeolite ion-exchanged one or more transition metals selected from the group of Ag, Cu, Zn, Fe, Co and Ni and has an excellent performance when used to remove the sulfur compound from the fuel gas irrespective of a moisture concentration in the fuel gas, and a method for removing sulfur compounds from sulfur compounds-containing fuel gas by use of an adsorbent of the above-mentioned type. The zeolite is favorably made of an X type zeolite, a Y type zeolite or a  beta  type zeolite.   <IMAGE>
Patent DE-60128750-T2 (DE)
Inventor: NEUHANN TOBIAS DR MED
IPC: A61F2/16
Filed: 2001-05-17
Granted: 2008-02-07
Abstract: An intraocular lens arrangement comprising an intraocular lens 10 having at least one haptic 14, 16 incorporating an aperture 18 therein, and a capsular tension ring 20 which passes through said aperture 18. <IMAGE>
Patent DE-60130899-T2 (DE)
Inventor: LARSSON PAER
IPC: H04L12/28
Filed: 2001-07-06
Granted: 2008-07-17
Abstract: A WAP gateway interconnecting a PLMN network with a private network is disclosed. The WAP gateway receives a request from a mobile terminal and accesses the WDP layer of the WAP protocol stack responsive to the request. Communications take place between the WDP layer of the protocol stack and at least a second layer of the protocol stack using SSL/TLS tunneling.
Patent DE-60132779-T2 (DE)
Inventor: ERCIN FERHAN
IPC: A47L15/42
Filed: 2001-07-26
Granted: 2009-02-05
Abstract: With the present invention, by using two or more floats, nested in one another, the switch can be triggered at different times and the time required for the machine to detect the undesired amount of water is shortened. Moreover, frequent calls for service are avoided by preventing the machine warnings due to momentary irregularities. The inner float (3) is provided with discharges (12) and bosses (9). Numerous discharges (12) of various shapes are provided at the regions in proximity to the side of the inner float (3) in order that unwanted water coming over the inner float (3) can easily be transferred inside the outer float chamber (5). For the same purpose, the top surface (6) of the inner float (3) is made inclined from the peak, point towards the edge. A hub (11) is provided on the upper surface (6) of the inner float (3). An outer float chamber (5) is formed inside the outer float (2). The outer float chamber (5) is provided with a drainage outlet (7).
Patent DE-60200224-T2 (DE)
Inventor: BERTINOTTI PIERO
IPC: B66C23/34
Filed: 2002-01-17
Granted: 2004-12-02
Abstract: A tower crane with composite structure, self-assembling, with sections which are hinged together with the use of horizontal hinges, the whole comprising a load-bearing arm (50) made up of several sections (23), (24), (25), (26) hinged together, and a tower composed of at least one pair of sections (20, 21) hinged together (at 12) and at least one section (22) which can be inserted into or telescoped from one of the other sections, and with tie rods (31, 32, 33) which work with the aforesaid arm (50), which arm comprises a first primary section (23), vertically higher at a front part thereof for connecting to a secondary section (24); a secondary section (24) interposed before a second primary section (25), of uniform height; a third primary section (26), hinged at one end (at 16) of its upper surface to the free end of the second primary section (25); actuating means (60, 62) for unfolding and re-folding of the joints between the primary sections (23, 25, 26); and means (68, 70; 32, 33) for re-establishing structural integrity between the first and second primary sections (23, 25) when the arm is in the deployed position. <IMAGE>
Patent DE-60206476-T2 (DE)
Inventor: LYNCH EDWARD
IPC: A61K6/00
Filed: 2002-03-21
Granted: 2006-07-13
Abstract: A method of treating dental carries and remineralizing lesions includes the steps of directing a stream of oxidizing gas onto a carious lesions for a period of time sufficient to kill microorganisms within the carious lesion; and thereafter applying to the lesion a remineralization formulation.
Patent DE-60206794-T2 (DE)
Inventor: KING ROGER MILNER
IPC: A47G19/22
Filed: 2002-11-19
Granted: 2006-07-27
Abstract: The invention provides a threaded container closure assembly includes: a container neck having an opening; a closure for said neck, the closure having a base portion and a skirt portion; a first screw thread on the neck, said first screw thread comprising one or more first thread segments; a second screw thread on an inner surface of the skirt of the closure, said second screw thread comprising one or more second screw thread segments; said first and second screw threads being configured to enable a user to secure, remove and resecure the closure into a sealing position on the neck by rotation of the closure on the neck; and wherein said first thread segments are shorter than said second thread segments; and wherein the second thread segments are each made up of one or more radially spaced projecting portions, each said portion extending radially no more than about 60 ° around the closure skirt.
Patent DE-60207387-T2 (DE)
Inventor: SCHMIDT J
IPC: C11D11/00
Filed: 2002-03-13
Granted: 2006-08-10
Abstract: This invention is related to a process for the controlled release into a cleaning environment of an active ingredient of a detergent or detergent additive composition wherein the cleaning environment, to which the detergent or detergent additive composition has been delivered, is exposed to an electric, magnetic or electromagnetic field at an appropriate point in time and for an appropriate time period wherein the release is effective by chemical and/or physical modification, initiated by said field, of at least one specific compound, the modified compound not being directly involved in bleaching; a detergent or detergent additive component with such functionality; a detergent or detergent composition comprising such detergent or detergent additive component; processes for cleaning dishes in an automatic dishwashing machine or for washing fabrics in a laundry washing machine using such detergent compositions; as well as the use of an electric, magnetic or electromagnetic field to control the release of an active detergent ingredient from a source thereof by selectively exposing the environment to which the source has been delivered to such a field.
Patent DE-60208164-T2 (DE)
Inventor: HULDEN JARL
IPC: G05D1/02
Filed: 2002-03-07
Granted: 2006-08-24
Abstract: A carrier, such as an autonomous surface treatment device, e.g., a robotic vacuum cleaner, has motive units, such as wheels, for transporting the carrier over a field of operation. The state of the carrier, which can be its position on the field of operation, is determined based, at least in part, on the actual track width of the motive units which will change depending on the carrier's driving mode. For example, when the carrier is operating in a driving mode where it is turning, the actual track width of the motive units will be different from the actual track width of those units when the carrier is proceeding straight ahead. A determination is made of the driving mode in which the carrier is operating at the time its state is to be determined, and the actual track width of the motive units that corresponds to that driving mode is employed in determining the state of the carrier.
Patent DE-60208926-T2 (DE)
Inventor: HUBERT T
IPC: G09C1/00
Filed: 2002-12-05
Granted: 2006-08-31
Abstract: A multiplier apparatus is arranged for multiplying a first long integer entity with a second long integer entity modulo a prime number. In particular, the comprises a pipelined multiplier core, whilst executing the overall multiplication in Montgomery fashion.