Patent SG-11201900904P-A (SG)
Title: Methods for cross coupling
Inventor: PINCHMAN JOSEPH ROBERT
IPC: C07F5/04
Filed: 2017-08-22
Abstract: PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) IiiiimmomiolollmonoloollloonoloillooloinovoimIE () International Publication Number WO 2018/039232 Al WIPO I PCT (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) (51) International Patent Classification: C07F 5/04 (2006.01) CO7D 239/26 (2006.01) CO7C 13/36 (2006.01) CO7D 263/56 (2006.01) CO7C 67/333 (2006.01) CO7D 413/08 (2006.01) CO7C 6 9 / 753 (2006.01) CO7F 5/02 (2006.01) CO7D 213/26 (2006.01) (21) International Application Number: PCT/US2017/048021 (22) International Filing Date: 22 August 2017 (22.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/378,453 23 August 2016 (23.08.2016) US (71) Applicant: KALYRA PHARMACEUTICALS, INC. [US/US]; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). (72) Inventors: PINCHMAN, Joseph Robert; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). HOPKINS, Chad Daniel; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). BUNKER, Kevin Duane; 10835 Road to the Cure, Suite 205, San Diego, Cal- ifornia 92121 (US). HUANG, Peter Qinhua; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). (74) Agent: MILLER, Kimberly J.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 2 I (3)) 1-1 0 (57) : Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of \" Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium catalyst and C a nickel catalyst, where the variables R 1 , R 2 , X and X 1 2 are as described herein. (54) Title: METHODS FOR CROSS COUPLING