Patent SG-11201803711S-A (SG)
Title: Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
Inventor: HUANG JINYU
IPC: G02B1/04
Filed: 2016-12-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) (43) International Publication Date ..... ..sr ,„,„01 22 June 2017(22.06.2017) WIPO I PCT ID Hit (10) WO International 2017/103790 111111111111111111IIIIIIIIIIII1111111111111111111111IIIIIIIIIMIIIIIIIIIIIIIII Publication Number Al (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, C08G 77/16 (2006.01) C08G 77/392 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C08G 77/20 (2006.01) G02B 1/04 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/IB2016/057584 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 13 December 2016 (13.12.2016) TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/267,310 15 December 2015 (15.12.2015) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 4056 Basel (CH). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: HUANG, Jinyu; 150 Hope Street, Ridgewood SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). New Jersey 07450 (US). CHANG, Frank; c/o Alcon Re- search, Ltd., 11460 Johns Creek Parkway, Johns Creek, Declarations under Rule 4.17: Georgia 30097 (US). ZHANG, Steve Yun; c/o Alcon Re- - as to applicant's entitlement to apply for and be granted a search, Ltd., 11460 Johns Creek Parkway, Johns Creek, patent (Rule 4.170) Georgia 30097 (US). JING, Feng; c/o Alcon Research, Ltd., 11460 Johns Creek Parkway, Johns Creek, Georgia — as to the applicant's entitlement to claim the of the priority 30097 (US). earlier application (Rule 4.17(iii)) (81) Designated States (unless otherwise indicated, for every Published: kind of national available): AE, AG, AL, AM, protection with international search report (Art 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, Il .4t C::: , Cr \ IN o en (54) Title: HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF Il ---- (57) : The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydior- ganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent Il c:::, and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophil - el ized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The ega ) hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about : f 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.