Patent SG-11201902667U-A (SG)
Title: Methods and systems for chromatography data analysis
Inventor: MAO NATHAN
IPC: G01N30/88
Filed: 2017-10-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 1110101011111 011101 0 011111a 0111111111H 111110 lil Oil lil Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/081203 Al 03 May 2018 (03.05.2018) WIP0 I PCT (51) International Patent Classification: eron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, GO1N 30/86 (2006.01) GO1N 30/88 (2006.01) Tarrytown, NY 10591 (US). MATTILA, John; C/o Regen- (21) International Application Number: eron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, PCT/US2017/058190 Tarrytown, NY 10591 (US). BAK, Hanne; C/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tar- (22) International Filing Date: rytown, NY 10591 (US). 25 October 2017 (25.10.2017) (74) Agent: RUSSELL, Thara; Bookoff Mcandrews, PLLC, (25) Filing Language: English 2020 K Street, Nw Suite 400, Washington, DC 20006 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/412,563 25 October 2016 (25.10.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicant: REGENERON PHARMACEUTICALS, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, NY 10591 (US). KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (72) Inventors: MAO, Nathan; C/o Regeneron Pharmaceuti- OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, cals, Inc., 777 Old Saw Mill River Road, Tarrytown, 10591 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (US). SHIERLY, Eric; C/o Regeneron Pharmaceuticals, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). SCHILLING, Bernhard; C/o Regeneron Pharma- (84) Designated States (unless otherwise indicated, for every ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, kind of regional protection available): ARIPO (BW, GH, = NY 10591 (US). CARVER, Scott; C/o Regeneron Pharma- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = — NY 10591 (US). MCDERMOTT, Stefanie; C/o Regen- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: METHODS AND SYSTEMS FOR CHROMATOGRAPHY DATA ANALYSIS = FIG. 3 T . ---- -- 1 - = ca a) as -c 11 a) a5 Q o as 0 = = = GI a) c C Q / c a = - = 2 0 11 co -1T:1 _ — Cr) I / Il / M C 1_ _L 0 ei 1-1 GC Volume 0 .-- - GO (57) : Embodiments of the present disclosure are directed to methods and systems for assessing integrity of chromatography 1 -1 columns, systems, and processes. The methods and systems can comprise one or more of extracting a block and signal combination for 0 analysis, performing a transition analysis, performing one or more statistical process controls, and/or implementing in-process controls ei based on the statistical process controls. [Continued on next page] WO 2018/081203 Al D ill EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, SK, SM, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))