baber/WOPTO huggingface dataset:
Patent EP-2145006-B1 (EP)
Inventor: CADOT CELINE
IPC: C12N9/04
Filed: 2008-03-12
Granted: 2011-05-11
Abstract: The present invention relates to a microbial expression system for the production of polypeptides based on the use of extrachromosomal DNA, whereby no antibiotic marker genes for the selection of the host cell but DNA sequences that encode glycerine-3-phosphate dehydrogenase are used, and, thus, the production of the desired polypeptide, e.g., xylanase, does not need the addition of antibiotics. The expression system is free from antibiotic-resistance genes. The invention further relates to a DNA sequence that encodes a polypeptide with glycerine-3-phosphate dehydrogenase activity as well as a polypeptide with glycerine-3-phosphate dehydrogenase activity.
Patent EP-2155229-B1 (EP)
Inventor: DURFEE STEVE L
IPC: A61K38/095
Filed: 2008-05-01
Granted: 2011-01-19
Abstract: The invention described herein provides an oral solid transmucosal dosage form that enhances transmucosal permeation of biologically active polypeptides across oral mucosal tissue and provides relatively rapid efficacious therapeutic onset thereof. Dosage forms prepared according to the invention can enhance transmucosal absorption of polypeptides in therapeutic serum concentrations to the recipient. The invention provides a solid dosage form for oral transmucosal absorption of a biologically active polypeptide, wherein the dosage form comprises a pharmaceutical composition comprising: a therapeutically active polypeptide; a bile salt; and an effervescent excipient component, which can comprise an effervescent couple and optionally a pH adjusting substance.; The invention includes a method of administering a biologically active polypeptide, as well as a method of enhancing transmucosal absorption of a biologically active polypeptide.
Patent EP-2185986-B1 (EP)
Inventor: LOPEZ THIERRY
IPC: G05B23/02
Filed: 2008-08-22
Granted: 2011-06-08
Abstract: The method of the invention is characterised in that it comprises the following steps: reception (3) by the calculator (2) of the erase request; inhibition (10) of all strategies of nominal detection of the defects by the calculator; initiation (13) of the strategy for detecting the defect concerned by the erase request using a model (12) stored in the calculator (11) of the simulated environmental conditions representative of the initial defect detecting conditions; analysis (13, 14) of the result of the initiation of the detection strategy for: 1. inhibiting the erase request if the defect is detected again, or 2. validating the erase request if the defect is not detected again; and erasing the defect code stored in the calculator (8).
Patent EP-2193793-B1 (EP)
Inventor: SATO FUMIYASU
IPC: A61P9/10
Filed: 2008-10-02
Granted: 2012-08-01
Abstract: 本発明は、優れた神経細胞死抑制作用を示す薬剤を提供する。 　本発明は、ピタバスタチン類及びドネペジル又はその塩とを組み合わせてなる神経細胞死抑制剤に関する。
Patent EP-2045603-B1 (EP)
Inventor: RENARD MARTIAL
IPC: G01N33/543
Filed: 2001-03-01
Granted: 2012-03-21
Abstract: A biosensor comprising at least a fragment of a protein receptor ready to bind to a suitable ligand at an active site and in which fragment, at least one of its amino acid residues located near the active site is a naturally present or substituted Cys, and having a fluorophore coupled to that Cys, is new. Independent claims are included with the following: (i) a protein-based chip comprising a solid support carrying the above immobilized biosensor; (ii) preparing the above biosensor, comprising: (a) selecting by research receptor the residues which, in the receptor-ligand complex are in direct contact with the ligand, or in contact by an intermediary water molecule, or whose surface accessible to solvent (ASA) is modified by binding or the ligand when using spheres of 1.4 -30, more preferably 1.4 - 2.9 angstroms for the solvent; (b) calculating accessibility to the solvent for the free receptor of atoms in positions gamma and eventually in position delta for each residue selected in (a) by using a 1.4 angstrom sphere, and selecting residues where the atom in position gamma or delta is accessible to the solvent (c) directly changing at least one of the residues selected in (b) to a Cys residue where the residue is not naturally Cys; and (c) coupling the S g atom of at least one of the Cys residues obtained in (b) or (c) with a fluorophore; (iii) preparing the claimed biosensor, comprising: (a) identifying the receptor active site mutating the whole, or a sub-set of the residues located in the vicinity of the active site and determining variations in the parameters of the interaction with the ligand (KD, k on, k off) due to each mutation or limited groups of changes (b) selecting Cys residues or residues changed to Cys situated in the vicinity of the active site along the sequence (c) directly changing at least one of the residues selected in (b) to a Cys where the residue is not naturally Cys; and (b) coupling the S g atom of at least one of the Cys residues obtained in (b) or (c) with a fluorophore; (iv) plasmid pMR1 having the sequence fully defined in the specification and deposited under CNCM number I-2386, or its derivative; (v) plasmid pMR1(VL-S93C) having the sequence fully defined in the specification and deposited under CNCM number I-2387, to prepare the claimed biosensor; (vi) a reagent for detecting, quantifying or localizing ligands, comprising at least the claimed biosensor; (vii) detecting, quantifying or localizing a ligand in a heterogeneous sample, comprising contacting the sample with the above reagent; and (viii) a kit for detecting inhibitors of ligand-receptor interactions comprising the above reagent.
Patent EP-2082967-B1 (EP)
Inventor: CHAMANDY PAUL ANDREW
IPC: D06H1/04
Filed: 2009-01-28
Granted: 2010-07-07
Abstract: There are disclosed several embodiments of label sets or arrays (67) having a substantial capacity for printed information (I) while maintaining all the labels (69-72;76,77;89-91) of the array associated and properly oriented with respect to each other, wherein all the labels of each set or array can be printed in a printer. The labels of the array are preferably printed in transverse rows across a label web to increase the number of labels that can be carried on a roll.
Patent EP-2216233-B1 (EP)
Inventor: GMUENDER RALF
IPC: B62D5/00
Filed: 2009-02-09
Granted: 2012-04-18
Abstract: The device has cam disks (3, 4) provided with shaft-type outer contours (33, 34). Electric drives are connected with a driven shaft (2) via the cam disks. A drive pin (47) and another drive pin are movably arranged with respect to slot-type recesses (46, 56) of cross-type disks (45, 55) about 90 degrees. The drive pins are movably engaged in slot-type recesses (41, 51) of transmission disks (40, 50). The cam disks are driven over the transmission disks by a drive shaft (1) in a rotational direction in a radial direction to a longitudinal axis in shaft positions.
Patent EP-2110013-B1 (EP)
Inventor: DEPPE MARKUS
IPC: A01D41/127
Filed: 2009-04-07
Granted: 2011-11-16
Abstract: The self-propelled agricultural machine has a traction drive, and a control element (36) for controlling driving speed. The control element is movable by a driver, where working devices are provided. The machine determines, whether a detected movement of the control element is a regular control movement or an emergency movement and transfers the working device into the inactive condition, if an emergency movement is detected. An independent claim is included for an escorting vehicle for a machine.
Patent EP-2148441-B1 (EP)
Inventor: LUEDECKE RAINER
IPC: H03K17/22
Filed: 2009-04-22
Granted: 2011-10-26
Abstract: The device (9) has a detecting unit for detecting operating voltage (U-B) that is applied to an electrical integrated circuit (IC) (3), where the device is an integral component of the IC to be initialized and is formed together with the IC in the form of a programmable logic component (8). A delay element is provided for delaying the applied operating voltage. An applying unit applies the delayed operating voltage to the IC as start-reset-signal (POR) by configuring the programmable logic component. The device is mobile or stationary and is operable by a battery or a network. Independent claims are also included for the following: (1) a method for automatic initialization of an electrical integrated circuit (2) an electrical integrated circuit comprising an unit for creating operating voltage.
Patent EP-2099105-B1 (EP)
Inventor: CARREAUD CHRISTIAN
IPC: H01T4/06
Filed: 2009-03-02
Granted: 2010-09-29
Abstract: The device has electrical connections (P4-P6) connecting a connection (K4) and common terminals (BN1, BN2) of respective interchangeable modules (M1, M2) to the terminals (BN1, BN2) and a common terminal (BN3) of an interchangeable module (M3), respectively. Electrical connections (P7-P9) connect ground terminals (BT1-BT3) of the respective modules (M1-M3) to the terminals (BT2, BT3) and a connection (K5), respectively. Electrical connections (P1-P3) connect connections (K1-K3) to phase terminals (BL1-BL3) of the respective modules (M1-M3), respectively. The electrical connections are constituted by insulated conductor wires.
Patent EP-2119711-B1 (EP)
Inventor: NOE SERGIO
IPC: C07D251/60
Filed: 2009-05-12
Granted: 2011-08-10
Abstract: The present invention relates to an improved process for the purification of melamine obtained by synthesis from urea which comprises the following steps: a) bringing raw melamine containing impurities of polycondensates and other by-products of the synthesis reaction, into solution, obtaining a solution/suspension in which the insoluble products are dispersed; b) subjecting the solution/suspension thus obtained to treatment to remove the CO 2  dissolved, reducing its concentration to values lower than 0.5% by weight; c) treating the solution/suspension obtained in step b), having a content of CO 2  lower than 0.5% by weight, with ammonia in a quantity ranging from 1 to 15%, preferably from 3 to 9% by weight, at a temperature ranging from 110 to 180°C, preferably from 130 to 140°C; d) putting the solution leaving step c) in contact with a solid catalyst, under the same conditions as step c). The present invention also relates to the equipment for effecting said process.
Patent EP-2127916-B1 (EP)
Inventor: SEBE MARC
IPC: B60G3/01
Filed: 2009-05-18
Granted: 2010-12-08
Abstract: The system has a rear axle whose wheel (3) is carried in rotation around an axis by a wheel carrier of the axle. A slider (4b) of the axle is fixed to the carrier and constituted by a single bar, where a guide is slidingly mounted along the slider. Elastic suspension units (82a, 82b) of suspension devices (8) are formed by a spiral spring, carried by the carrier and placed symmetrically on both sides of the bar. Each unit applies force that depends on a sliding position of a suspended element on the bar, between the carrier and the suspended element that is formed by a crossbar (60).
Patent EP-2284496-B1 (EP)
Inventor: WASLOWSKI KAI
IPC: G01D3/08
Filed: 2009-07-30
Granted: 2011-10-19
Abstract: The sensor (10) has a detection branch (22-1) with a filter, to which the received signal is supplied. The output signal of the detection branch is compared with a comparator against a threshold value. Another detection branch (22-2) is provided parallel to the former detection branch, in which another filter (30-2) is arranged. The output signal of the latter detection branch is compared with another comparator (32-2) against another threshold value. The latter comparator provides the comparison result and a stability signal is generated in dependence of all comparison results. An independent claim is also included for a method for providing a stability signal.
Patent EP-2194092-B1 (EP)
Inventor: KOELBLIN CHRISTIAN
IPC: C08L23/00
Filed: 2009-11-19
Granted: 2012-01-04
Abstract: Crosslinkable composition comprises a polymer matrix, which comprises one or more polyolefins and terpolymer of polyvinyl acetal (PVA) as reducing agent for the formation of water treeing, where the amount of PVA is greater than 10 wt.% in the composition. An independent claim is included for an electrical cable (1) comprising an electrical conductor (2) surrounded by a semiconductor first layer (3), an electrically insulated second layer (4) and a semiconductor third layer (5), where the first, second and third layers are crosslinked, and the second layer is obtained from the composition.
Patent EP-2107195-B1 (EP)
Inventor: VOUTILAINEN MIKKO
IPC: B62D33/037
Filed: 2009-03-31
Granted: 2011-08-10
Abstract: The invention is a toggle latch (10) by means of which two parts, such as a casing cover and a casing body, or similar objects, can be latched together. The first part of the toggle latch is comprised of a body (20), wherein a securing aperture (31) is provided for a securing pin (30), and to which body a latch lever (25) and an adjustable eye bolt (27) have been attached. The other part of the toggle latch is comprised of a counterpiece (22), such as a hook. A toggle latch according to the invention includes a securing pin and a spring (34), the spring force of the spring being directed at the securing pin so that the securing pin secures the latch lever in the securing aperture of the protrusion (36) of the body of the toggle latch. The securing pin is most preferably U-shaped and made from round steel bar. The spring is a coil spring located around the securing pin and secured to the securing location (35) of the securing pin. The protrusion (36) of the body may be shaped in such a way that, when the latch lever is being latched, the securing pin makes contact with the protrusion and becomes secured in the securing aperture of the protrusion,
Patent EP-2245117-B1 (EP)
Inventor: G NZALEZ LEON JUAN ANTONIO
IPC: C08G83/00
Filed: 2009-02-20
Granted: 2012-04-25
Abstract: This invention relates to the modification of bitumen by polymeric materials used particularly for the preparation of asphalt mixtures with enhanced mechanical properties, wherein the polymeric materials are selected from additives capable of forming a supramolecular assembly. The modified bitumen may be used for the fabrication of asphalts mixtures with mineral aggregates used in construction or maintenance of sidewalks, roads, highways, parking lots or airport runaways and service roads and any other rolling surfaces.
Patent EP-2242472-B1 (EP)
Inventor: POLONKA JACK
IPC: A61K8/29
Filed: 2009-01-29
Granted: 2011-11-16
Abstract: A cosmetic composition is provided which includes a silicone elastomer, a cationic copolymer with monomeric units selected from at least an acryloylethyl tri(C1-C3 alkyl)ammonium salt, and light reflecting platelet shaped particles. The compositions are particularly useful to impart radiance as well as soft focus effects onto the skin. A particular useful cationic copolymer is that of acrylamide/acryloylethyl trimethylammonium chloride/tris(hydroxymethyl)acrylamidomethane copolymer.
Patent EP-2222994-B1 (EP)
Inventor: KAYANUMA HIDETAKA
IPC: F16B31/02
Filed: 2009-03-10
Granted: 2011-09-21
Abstract: A coupling structure for an absorption refrigeration circuit includes a gasket held between two coupling members. The gasket has a protruding part that elastically deforms when clamped between adjoining faces of the two coupling members.
Patent EP-2276994-B1 (EP)
Inventor: AXFORD RICHARD DESMOND JOSEPH
IPC: F41B3/02
Filed: 2009-05-13
Granted: 2011-12-14
Abstract: The present disclosure relates to a launch system for air vehicles. More specifically, the present disclosure relates to launching unmanned air vehicles (UAVs) that are unable to be launched by hand. The present disclosure provides a system for launching a winged vehicle, including: a projectile launching device; and a device for converting projectile momentum into acceleration of a winged vehicle.
Patent EP-2221363-B1 (EP)
Inventor: FLEISCHMANN BERND
IPC: A61K35/545
Filed: 2001-12-27
Granted: 2014-07-30
Abstract: Embryonic stem cells, embryonic germ-line cells and/or adult stem cells (A) that contain at least one each of reporter gene (RG1) and resistance gene (RG2) under control of the same promoter and present in at least one or two vector constructs. The promoter is cell specific and/or development specific. Independent claims are also included for the following: (a) differentiating or differentiated cells (B) produced from (A); (b) method for producing differentiating (A); (c) cultures (C) of (A) or (B); (d) method (D) for toxicological testing using the cultures (C); (e) method (E) for generating transgenic non-human animals using (A) or (B); (f) transgenic animals produced by method (E); (g) method for testing the developmental stage of mammalian cells; and (h) differentiated cells, especially of the heart, prepared from (A) or (B).
Patent EP-2305741-B1 (EP)
Inventor: CARTIER HERVE
IPC: C08K5/00
Filed: 2006-03-03
Granted: 2012-10-10
Abstract: Crosslinkable, flame retardant polymer compositions are provided containing a polyamide or polyester; a flame retardant system; and a crosslinking agent.
Patent EP-2248759-B1 (EP)
Inventor: BALZARIN FRANCO
IPC: B08B9/42
Filed: 2010-03-22
Granted: 2011-12-21
Abstract: Machine (1) for treating containers, in particular in a plant for bottling food products, which comprises a turntable (70) rotatably mounted on a support frame and a plurality of holding devices (2) for containers (8) mounted peripherally on such a turntable (70). Each of the holding devices (2) comprises: a support structure (4) mechanically connected to the turntable (70); at least two arms (15) pivoted to the support structure (4) to rotate around its own first rotation axis (Y) and each provided with at least one holding body (20) intended to grasp the container (8); actuator means (18) mechanically connected to the arms (15) to actuate them to rotate around the first rotation axis (Y) between at least one open position, in which the holding bodies (20) are separated from one another so as to receive or release the container (8), and at least one closed position, in which the holding bodies (20) are close to one another to hold the container (8) between them.  Each of the holding bodies (20) of the holding device (2) is connected to a support body (15') of the respective arm (15) through at least one articulation (21) suitable for allowing the holding body (20) itself to rotate around at least a second rotation axis (Z) lying on a plane (À) substantially perpendicular to the first rotation axis (Y) of the arms (15) and passing through them.
Patent EP-2276225-B1 (EP)
Inventor: ZHANG HONGYUAN
IPC: H04M3/30
Filed: 2004-04-08
Granted: 2011-10-05
Abstract: The present invention discloses a test method of digital subscriber line (DSL) broadband service applicable to tests of CO and CPE equipments in a DSL broadband service system. The method comprises: A) disconnecting the equipment to be tested from the equipments at the other end; B) connecting the equipment to be tested with a configured test board, simulating the other-end equipments of the equipment to be tested with the test board, and making at least one of the tests of activation handshake, ATM layer, and high-hierarchy protocols. With this method, the problem in testing of DSL lines and locating the failures thereof can be solved, thus working efficiency is improved and operation cost lowered.
Patent EP-2451474-B1 (EP)
Inventor: NATHWANI AMIT
IPC: C12N15/85
Filed: 2010-07-08
Granted: 2013-12-18
Abstract: An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.
Patent EP-2471551-B1 (EP)
Inventor: GREGERSEN JENS PETER
IPC: A61K39/145
Filed: 2005-09-09
Granted: 2017-02-01
Abstract: The inventor has realised that certain pathogens can grow in mammalian cells, in particular Vero cells, and that these pathogens could pose a contamination risk when producing vaccine antigens in these cells. The invention thus provides methods to test for these pathogens.
Patent EP-0007349-B1 (EP)
IPC: B60R19/34
Filed: 1978-07-07
Granted: 1981-07-15
Abstract: dispositif pare-chocs concernant principalement l'absorption des chocs de haute energie qui peuvent etre: subis par tous types de mobiles ou de vehicules et en particuliers par les vehicules automobiles. Dans son mode preferentiel de realisation, le dispositif comporte une ou plusieurs capacites (17, 18) disposees le plus souvent a l'avant du vehicule et contenant un fluide hydraulique. Chacune de ces capacites est reliee par une canalisation (22, 23) a une enceinte receptrice deformable par expansion (24, 25) et remplie egalement de fluide. Sous l'action d'un choc violent, ces capacites s'ecrasent en ejectant le fluide que'elles contiennent en direction des enceintes receptrices dont les parois se dilatent au fur et a mesure de l'arrivee du fluide. C'est la deformation plastique des ces parois qui absorbe l'energie du choc. Ce dispositif convient plus particulierement a la realisation de pare-chocs a haute absorption pour automobiles et comporte de preference des enceintes receptrices en acier austenitique a austenite instable.
Patent EP-0015270-B1 (EP)
Title: Transportation of fluent material
IPC: B65D5/49
Filed: 1979-06-01
Granted: 1983-07-27
Abstract: A method of and a means for use in packaging bulk quantities of a fluent material for the ready transportation thereof is proposed which involves the provision of cardboard container (11) having dividers (12) therein separating the container into individual and adjacent compartments (13) each containing a respective filled, flexible bag (14) of said material, the bags (14) substantially filling the respective compartments (13), and the dividers (12) and container (11) being such as to sustain the dynamic and static loads applied thereto during transportation.
Patent EP-0017847-B1 (EP)
IPC: B22D11/12
Filed: 1980-04-01
Granted: 1981-12-30
Abstract: An apparatus for the removal, accompanied by simultaneous turning, of cut-to-length hot strand sections from the delivery or run-out roller tables of a multistrand continuous casting installation for steel. The pivot shaft of pivotal levers, provided with receiver or take-up portions for the cut-to-length strand sections, is located below a cooling bed arranged laterally of the delivery or run-out roller tables, approximately at the center between the cooling bed and the roller table located furthest from such cooling bed. By virtue of the foregoing and due to the constructional configuration of the receiving portions or strand section-receivers and a slide or chute operatively associated with the roller table situated closest to the cooling bed, it is possible, with the aid of only one single pivot mechanism or device, to conjointly directly transfer a number of strand sections which are simultaneously turned through an angle of about 90 DEG , from different run-out roller tables, onto the cooling bed and to further displace the entire stack of strand sections.
Patent EP-0029956-B1 (EP)
IPC: B25B27/00
Filed: 1980-11-19
Granted: 1984-11-28
Abstract: A threaded bore in a flange (4) of a reactor pressure vessel (1) can be plugged or sealed by means of a sealing or plugging element (6) and a tool (8) with the reactor pressure vessel cover (2) in place. In order to obtain a tight seal, the plugging element (6) is joined in a detachable manner to the tool (8) and has a shoulder (11) thereof set down on the upper face (4a) of the flange (4). An O-ring (15) borne by the plugging element (6) is compressed between two relatively movable parts 12, 13 of the tool and is thereby pressed radially outwardly against the peripheral surface of a free turn (7) of the threaded bore. The relative movement of the two parts 12, 13 is effected by rotation of a nut 20. <IMAGE>