baber/WOPTO huggingface dataset:
Patent HU-0000073-A3 (HU)
Title: Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase
IPC: C07D401/14
Filed: 1997-09-11
Abstract: Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c and d represents N or NR<9> wherein R<9> is O<->, -CH3 or -(CH2)nCO2H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR<1> or CR<2>; or each of a, b, c, and d are independently selected from CR<1> or CR<2>; each R<1> and each R<2> is independently selected from H, halo, -CF3, -OR<10>, -COR<10>, -SR<10>, -S(O)tR<11> (wherein t is 0, 1 or 2), -SCN, -N(R<10>)2, -NR<10>R<11>, -NO2, -OC(O)R<10>, -CO2R<10>, -OCO2R<11>, -CN, -NHC(O)R<10>, -NHSO2R<10>, -CONHR<10>, -CONHCH2CH2OH, -NR<10>COOR<11>, -SR<11>C(O)OR<11>, -SR<11>N(R<75>)2; y is 0 (zero) or 1; n is 0, 1, 2, 3, 4, 5 or 6; T is -CO-; -SO-; -SO2-; or -CR<30>R<31>; Z represents alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -OR<40>, -SR<40>, 1C-R<40>R<42>, (i), (ii), -NR<40>R<42>, (iii). Pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Patent HU-0004239-A3 (HU)
Title: Process for synthesizing phosphodiesters
IPC: C07F9/117
Filed: 1998-01-27
Abstract: A process for preparing a phosphodiester of the formula: is described that involves (1) reaction of a first alcohol with phosphorous trichloride to form a phosphorodichlorodite, (2) reaction of the phosphorodichlorodite with an amine to form a phosphorodiamidite, (3) reaction with a second alcohol (which may be the same as the first alcohol) to form a phosphoramidite diester, and finally, (4) hydrolysis and oxidation of the phosphoramidite to form the phosphodiester. R and R1 may represent aliphatic, aromatic, heterocyclic, peptidic, peptoid, deoxyribo- or ribonucleotidic or nucleosidic, or organic chelating moieties.
Patent HU-0100248-A3 (HU)
Title: Alumina-zirconium oxide-silicon oxide based products with improved microstructure, made in arc furnace
IPC: C04B35/484
Filed: 2001-01-18
Abstract: Oxidized alumina-zirconia-silica (AZS) refractories containing 40 wt % to 55 wt % Al2O3, 32 wt % to 45 wt % ZrO2, 10 wt % to less than 16 wt % SiO2 and 1 wt % to 3 wt % of an alkali metal oxide selected from Na2O, K2O and mixtures thereof have a microstructure essentially comprising alpha-alumina crystals, free zirconia crystals, eutectic crystals and an intercrystalline vitreous phase. At least in an active area, more than 20% by number of the free zirconia crystals have a dendritic shape and are interleaved with each other and with eutectic crystals and at least 40% by number of the dendritic free zirconia crystals have a dimension greater than 300 mum.
Patent HU-0200925-A3 (HU)
Title: Power electronics component with improved thermal properties
IPC: H01G2/08
Filed: 2000-04-07
Abstract: A power electronics component having a housing a cover plate and an electrically active region. The electrically active region is disposed in the housing in such manner that a gap exists between the electrically active region and the inner wall of the housing. The gap is filled with a moisture absorbent bulk granular material.
Patent HU-0201631-A3 (HU)
Title: Composition comprising alkaline sphingomyelinase for use as a dietetic preparation, food supplement or pharmaceutical product
IPC: A23L1/305
Filed: 2000-06-07
Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
Patent HU-0400466-A3 (HU)
Title: G-csf conjugates
IPC: A61K47/34
Filed: 2002-07-10
Abstract: Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.
Patent HU-0500029-A3 (HU)
Title: Production process of recombinant placental growth factor
IPC: C12P21/02
Filed: 2002-02-05
Abstract: Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies, III) renaturation of the expressed protein, IV) ion-exchange chromatography, V) reverse-phase chromatography.
Patent HU-9702481-A3 (HU)
Title: New n-benzylpiperazine compounds, process for producing them and the pharmaceutical compositions which containing them
IPC: C07D339/04
Filed: 1997-12-16
Abstract: N-benzyl piperazine derivatives of formula (I), their isomers and addition salts with acids and bases are new. R1 = 1-6 C alkyl; X = O or S; R2 = 1-8 C alkyl (optionally substituted by CO2H or 1-6C alkoxycarbonyl), 1-6C alkoxy, phenyl (optionally substituted by halo, 1-6C alkyl or alkoxy, OH or trihalomethyl), 3-7C cycloalkyl (optionally substituted by ≥ 1 phenyl (optionally substituted by ≥ 1 halo or 1-6C alkyl or alkoxy, OH or trihalomethyl)), 4-(2,3-dithiacyclopent-1-yl)-butyl, pyridyl, NH2 (optionally mono- or di-alkylated with 1-6C alkyl), or a chroman or chroman-alkyl group; and R3 = H, 3-7C cycloalkyl, CHO, phenyl (optionally substituted by halo, 1-6C alkyl or alkoxy, OH or trihalomethyl), pyridyl or 1-20 C alkyl (optionally substituted by ≥ 1 halo, phenyl or cycloalkyl (optionally substituted as described above as in R2)), 1-6C alkoxy, OH or pyrrolidinyl.
Patent HU-9802565-A3 (HU)
Title: N-benzyl-dioxothiazolidinylmethyl-benzamide derivatives, pharmaceutical compositions containing them and process for producing the same
IPC: A61K31/426
Filed: 1996-05-30
Abstract: The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) <CHEM> Äwherein R<1> and R<2> denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R<1> and R<2> link to form a methylenedioxy group, R<3> denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid lineÜ, and processes for preparing the same.
Patent WO-02077945-A3 (WO)
Title: Traffic predictions
Inventor: MINTZ YOSEF
IPC: G06Q10/00
Filed: 2002-02-08
Abstract: A method is provided for predicting load of traffic of vehicles that are travelling according to non reference route plan, provided with Dynamic Route Guidance capability of their PMMS, in a Forward Time Interval related Route Segment and according to a predetermined protocol between mobile systems and a non mobile system platform of a SODMS. Using mobile units, a traffic prediction query is receiving according to a predetermined differential traffic load match process. A match process is performed by each of the mobile units and, according to a match, a predetermined response procedure is enabled, wherein a response procedure in each mobile unit uses a predetermined random process to select an allocated slot in which to transmit a predetermined signal, which provides an improved way to predict traffic in conjunction with off line database statistics, preferably with such that are being adaptively corrected by prior data and method to predict traffic which do not include, or lack sufficient erratic traffic information.
Patent WO-2004051616-A3 (WO)
Title: Dispositif d'affichage a diodes organiques electroluminescentes (oled) et procede d'activation de ce dispositif
Inventor: JOHNSON MARK THOMAS
IPC: G09G3/32
Filed: 2003-11-25
Abstract: L'invention concerne un procédé d'activation d'un dispositif d'affichage OLED possédant des première et seconde électrodes entre lesquelles se trouve une couche organique formant une pluralité d'éléments d'émission de lumière. Ce procédé consiste à appliquer à un élément d'émission de lumière une tension parmi une fourchette de tensions spécifiques, au sein de laquelle le risque de courts-circuits entre les électrodes est réduit, et à commander le cycle de service dudit élément d'émission de lumière, de telle manière qu'une intensité de lumière souhaitée est émise à partir dudit élément d'émission de lumière. La probabilité de courts-circuits dans des pixels d'un dispositif d'affichage OLED est réduite, lorsqu'est écartée l'utilisation des pixels d'affichage à l'intérieur des fourchettes de tensions, dont le risque de courts-circuits est élevé. Cette limitation de la tension appliquée est compensée par la commande du cycle de service de l'élément d'émission de lumière.
Patent WO-0238667-A3 (WO)
Title: Caoutchouc naturel produit a partir de latex et composition renfermant celui-ci
Inventor: TORATANI HIROTOSHI
IPC: B29B13/06
Filed: 2001-10-31
Abstract: L'invention concerne un caoutchouc naturel obtenu par séchage d'un latex de caoutchouc naturel rassemblé sans coagulation, un sécheur à vide et/ou un sécheur de type à tablier étant utilisés pour le séchage. De plus, l'invention concerne un procédé de production d'un mélange de caoutchouc naturel et de charge préparé par ajout, à un latex de caoutchouc naturel, d'au moins un des produits parmi le noir de carbone et les charges inorganiques, un caoutchouc naturel ajoutant un stabilisateur de viscosité comprenant des composés d'hydrazide ou des esters de dérivés d'acide aromatique ou aliphatique polycarboxylique à ces caoutchouc naturel et mélange de caoutchouc naturel et de charge, ainsi qu'une composition de caoutchouc préparée au moyen des caoutchoucs naturels susmentionnés et présentant d'excellentes qualités de productivité, de résistance à l'abrasion et à la fracture.
Patent WO-2004018034-A3 (WO)
Title: Dispositif de traitement d'articulation par ultrasons
Inventor: YANG SEONG-SEOK
IPC: A61H23/00
Filed: 2003-08-20
Abstract: L'invention concerne un dispositif de traitement d'articulation par ultrasons comprenant plusieurs éléments réalisant des vibrations ultrasonores sous l'application de tensions de commande. Une bande support contient une surface interne sur laquelle sont agencés les éléments ultrasonores selon une structure déterminée, cette bande étant d'une largeur suffisante pour pouvoir suffisamment entourer le bras ou la jambe à traiter. Une paire d'attaches femelle et mâle est fixée amovible aux deux portions d'extrémité de la bande support. Un connecteur mâle ou femelle est ajusté sur l'extérieur de la bande support, et couplé à un connecteur femelle ou mâle relié à une alimentation électrique extérieure via un cordon électrique afin de délivrer de l'énergie électrique aux éléments ultrasonores.
Patent WO-0212874-A3 (WO)
Title: Method and system for measuring active animal glue concentration in industrial electrolytes
Inventor: BAS WLODZIMIERZ
IPC: G01N27/416
Filed: 2001-04-02
Abstract: A method consists in measuring ac impedance spectrum using gold, platinum or carbon working ultramicroelectrodes (1). The direct current DC potential pulse which overlaps with alternating current AC signal of an amplitude in the range from 0.005 to 0.015 V and frequency in the range from 10?-2 to 106¿ Hz is applied at the electrode. The value of said DC potential pulse for a process of copper electroefining is in the range from - 0.4 to - 0.9 V in relation to a platinum reference electrode (2). Resistance values characteristic of a given electrolyte (E) are obtained from said AC impedance spectrum and compared with standard characteristic obtained by standard additions method. A measuring system consist of electrodes (1, 2, 3) placed inside a meauring cell (4) filled with flowing industrial electrolyte. The electrodes (1, 2, 3) are joined to a spectrum analyser (12) controlled by a programming apparatus (13).
Patent WO-0167620-A3 (WO)
Title: Transmission de signaux de synchronisation liaison montante dans des systemes duplex a repartition dans le temps
Inventor: NYSTROEM JOHAN
IPC: H04B7/26
Filed: 2001-03-08
Abstract: Un réseau de communication d'accès multiple à répartition dans le temps- répartition par code synchrone (TD-SCDMA) applique une structure trame ayant un tiroir de taille constante. Des données de signalisation, comportant notamment des données de synchronisation, d'une connexion particulière sont ajoutées à un décalage prédéterminé du début d'un tiroir sélectionné dans la trame, et le décalage est transmis sur le canal de diffusion commun (BCH). Les données de synchronisation sont, de préférence, transmises dans le même tiroir par le canal d'accès aléatoire (RACH). Pour établir une liaison de télécommunications, un émetteur fonctionnant dans le réseau sélectionne un premier mot de code et une première localisation temps dans un créneau temporel montant, ajoute le premier mot de code à la première localisation temps dans le créneau temporel montant et transmet le premier mot de code à la localisation temps choisie. Un récepteur recherche une correspondance du premier mot de code dans au moins une localisation temps dans au moins un créneau temporel destiné à la liaison montante et détermine un ensemble éventuellement vide de canditats potentiels pour les mots de code et localisations. Si l'ensemble de candidats n'est pas vide, il évalue la différence de temps entre au moins un des candidats localisation temps et au moins une localisations temps prédéterminées.
Patent SK-2682004-A3 (SK)
Title: Method of using water soluble polymers in a membrane biological reactor
Inventor: COLLINS JOHN H
IPC: C02F1/56
Filed: 2003-01-06
Abstract: A method of conditioning mixed liquor in a membrane biological reactor comprising adding to the mixed liquor an effective coagulating and flocculating amount of one or more water soluble cationic, amphoteric or zwitterionic polymers, or combination thereof and methods of reducing membrane fouling, enhancing membrane flux and reducing sludge production.
Patent SK-3922000-A3 (SK)
Title: The use of ribavirin for the manufacture of a pharmaceutical composition, the use of interferon alpha for the manufacture of a pharmaceutical composition and pharmaceutical compositions
Inventor: ALBRECHT JANICE K
IPC: A61K38/12
Filed: 1998-09-16
Abstract: There is disclosed the use of ribavirin, interferon alpha or a combination of ribavirin and interferon alpha for the manufacture of a pharmaceutical composition for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA by a method comprising administering an effective amount of ribavirin in association with an effective amount of interferon alpha, wherein the patient is one having failed to respond to a previous course of interferon alpha therapy. The compositions may be used in a method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of from 20 up to 80 weeks.
Patent SU-1009281-A3 (SU)
Inventor: LACH RAJNKHARD
IPC: F02B19/12
Filed: 1977-05-13
Granted: 1983-03-30
Abstract: An internal combustion engine with a main combustion chamber defined by the cylinder and the piston has a separate ignition chamber located in the cylinder head which communicates with the main combustion chamber through a narrow channel. The channel terminates tangentially in the chamber and the flow of combustible mixture into the chamber generates therein a vortex which aids in ignition and combustion. The chamber includes spark-producing electrodes but does not receive additional fuel. In order to improve the ignition process, i.e., to lower the energy required for ignition, the walls of the ignition chamber are cooled to a controlled degree by changing the size of an air gap when the chamber expands or contracts, thereby changing the heat flow from the ignition chamber to the cooled portions of the engine.
Patent SU-826965-A3 (SU)
Inventor: GERMES YULIUS
IPC: D06F43/06
Filed: 1977-07-25
Granted: 1981-04-30
Abstract: The present invention relates to a closed cycle apparatus for the rapid, continuous and waterless dyeing of a textile or plastic material with a dyestuff dissolved or suspended or dispersed in a high boiling solvent (such as glycol or glycol ether or other members of the alcohol family) for carrying out the dyeing step, after which the dyed textile or plastic material subsequent to cooling is washed with a low boiling liquid (such as methanol or ethanol) and then dried. The apparatus is constructed so as to operate under non-aqueous or substantially non-aqueous conditions with the complete or substantially complete recovery and recycling of the used dyestuff, the used high boiling solvent and the used low boiling wash liquid. In this way, the apparatus can be operated at a relatively low cost and in a completely or substantially completely closed cyclic system with essentially complete recovery and reuse of the treating fluids so as to greatly minimize the cost of operating the dyeing apparatus and also without any pollution of our natural water resources. Pollution of many of our rivers and wells has taken place in the past where effluents of a substantially aqueous nature containing serious amounts of polluting substances were discharged into rivers and the like thereby creating environmental problems.
Patent SU-974935-A3 (SU)
Inventor: DZHOUNZ DZHEREJNT
IPC: C07C233/08
Filed: 1979-06-18
Granted: 1982-11-15
Abstract: The invention concerns di- and tri-esters derived from alkanoic, (cycloalkyl)alkanoic, benzoic or phenylalkanoic acids with N-(acylaminoalkyl)-dihydroxyphenylethanolamines, and pharmaceutically acceptable salts thereof; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The esters are useful for the topical treatment of an area of inflammation affecting the skin of a warm-blooded animal. Representative esters of the invention are 1-[3,4-bis(pivaloyloxy)phenyl]-2-[2-(2-phenylacetamido)ethylamino]-eth anol, 1-[3,4-bis(pivaloyloxy)phenyl]-2-[1,1-dimethyl-2-(2-phenoxyacetamido)- ethylamino]-ethanol, and the hydrochlorides and hydrobromides thereof.
Patent SU-976848-A3 (SU)
Inventor: BAKH NIKOLAS DZHEJMS
IPC: C07D231/56
Filed: 1981-01-20
Granted: 1982-11-23
Abstract: Indazol tautomers(I; one of R and R1 is H, and the other is H(R2)2; R2 = H, allyl, Me, Et, n-Pr) were prepd. and they were effective in the treatment of Parkinsonism and in the inhibition of prolactin. Thus, the reaction of 4-acetamidocy-clohexanone with HC(OMe)2NMe2 gave 4-acetamido-2-≮(dimethylamino) methylene≉ cyclohexanone, the latter was treated with N2H4 to give I.
Patent SU-1075979-A3 (SU)
Inventor: BERNER GODVIN
IPC: C07D211/46
Filed: 1981-11-16
Granted: 1984-02-23
Abstract: The invention relates to ester mixtures of polyalkylpiperidine derivatives of the formulae I and II    <IMAGE>  (I)   <IMAGE> (II) in which R1 is hydrogen or methyl, R2 is hydrogen, C1-12 alkyl, C3-8 alkenyl, C7-11 aralkyl, cyanomethyl or C2-4 acyl, R3 is C1-18 alkylene, C2-18 oxaalkylene, Chd 2-18 thiaalkylene, C2-18 azaalkylene or C2-8 alkenylene and R4 is C1-4 alkyl. These mixtures are suitable as stabilizers for plastics.
Patent SU-1327800-A3 (SU)
Inventor: BERGKVIST LARS ANDERS
IPC: G02B27/60
Filed: 1982-05-21
Granted: 1987-07-30
Abstract: An instrument for marking leading lines, comprising a front screen and a behind screen (1, 2, 15, 16), which include opaque lines (3) separated by transparent interstices (4), whereby an interference pattern, a so-called moiré pattern, arises when viewing the instrument. The screens have different division, i.e. different distances between the opaque lines. According to the invention, each of the screens (1, 2, 15, 16) comprises a plate, which at its centre is bent to an obtuse angle (v), which screen plates are positioned by means of attachment means (6, 7, 8) so that the obtuse angles (v) face toward each other, in which case the front screen plate (1) is provided with a denser screen division than the behind screen plate (2), or alternatively so that the obtuse angles (v) face away from each other, in which case the front screen plate (15) is provided with a sparser screen division than the behind screen plate (16).
Patent SU-1279522-A3 (SU)
Inventor: KURT SHTADE
IPC: B29C48/52
Filed: 1983-02-22
Granted: 1986-12-23
Abstract: Изобретение касается переработкипластических масс, и может быть  использовано в машиностроении. Цель  изобретения состоит в расширении технологическихвозможностей за счет  обеспечения интенсивного перемешиванияпри подаче дополнительных присадочньпсматериалов. Для этого в корпусерасположены с возможностью зацепленияи однонаправленного вращения  два самоочищающихся шнека, имеющих в зоне расплавления участки меньшего  диаметра с повьшенным числом заходов- трехзаходные, а в зоне смеши.вания - участки большего диаметра с  пониженным числом заходов - двухзаходныедля образования в зоне смешиванияувеличенного живого поперечногосечения. Корпус имеет отверстие  для загрузки перерабатываемого материалав зоне расплавления и отверстиедля загрузки присадочньк дополнительныхматериалов в зоне смешивания. При работе присадочные дополнительныематериалы подаются в зону с  увеличенным живым поперечным сечениiем, где они могут смешиваться с пере- §  рабатываемым, подаваемым из зоны расО) плавления материалом в требуемых косличествах и практически без обратногоподпора, так как в зоне смешиванияимеется необходимый свободный  объем. Присадочные материалы могут  подводиться также частично в зоне расюплавления, а пластифицируемые материалыт в зоне смешивания с пониженсоел to HbtM числом заходов шнеков, что обеспечиваетнеобходимую вариацию подачи  перерабатываемого и присадочного маN9териалов. 1 з.п. ф-лы, 3 ил.
Patent SU-1452478-A3 (SU)
Inventor: LABA IV
IPC: C07C319/22
Filed: 1986-03-24
Granted: 1989-01-15
Abstract: The polysulphide is heated with a substance capable of dissolving elemental sulphur. After cooling, the polysulphide reduced to a lower numbver of S atoms is separated from the substance, which can be recovered. An important use consists in converting the polysulphide to the form of dimethyl disulphide, the solvent used for the dissolution of sulphur deposited in conduits, particularly those used for natural gas.