baber/WOPTO huggingface dataset:
Patent DE-69432543-D1 (DE)
Inventor: SELTEN GERARDUS CORNELIS MARIA
IPC: C12N15/52
Filed: 1994-06-30
Granted: 2003-05-28
Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
Patent DE-69508247-D1 (DE)
Inventor: CROUD VINCENT
IPC: C11D3/39
Filed: 1995-06-30
Granted: 1999-04-15
Abstract: PCT No. PCT/GB95/01537 Sec. 371 Date Apr. 21, 1997 Sec. 102(e) Date Apr. 21, 1997 PCT Filed Jun. 30, 1995 PCT Pub. No. WO96/01311 PCT Pub. Date Jan. 18, 1996A liquid concentrate peroxide composition contains a combination of sequestrants which together are capable of universal sequestration of transition metal ions which would otherwise cause decomposition of the peroxide. The combination preferably includes a sequestrant capable of sequestering cobalt and a sequestrant capable of sequestering metal ions other than cobalt. A particularly preferred combination includes a poly(methylene phosphonic acid) and nitrogen-donor type sequestrants such as dipyridylamine or triazacyclononane.
Patent DE-69510410-D1 (DE)
Inventor: HOEKSTRA MERL F
IPC: C12Q1/68
Filed: 1995-01-23
Granted: 1999-07-29
Abstract: Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods using the polynucleotides in cell-proliferative disorders.
Patent DE-69511085-D1 (DE)
Inventor: CAPECI SCOTT
IPC: C11D1/00
Filed: 1995-04-18
Granted: 1999-09-02
Abstract: A process for preparing high density detergent agglomerates having a density of at least 650 g/l is provided. The process comprises the steps of: (a) continuously mixing a detergent surfactant paste and dry starting detergent material into a high speed mixer/densifier to obtain detergent agglomerates, wherein the ratio of the surfactant paste to the dry detergent material is from about 1:10 to about 10:1; (b) mixing the detergent agglomerates in a moderate speed mixer/densifier to further densify and agglomerate the detergent agglomerates; and (c) drying said detergent agglomerates so as to form the high density detergent composition. The process may include one or more additional processing steps such as adding a coating agent after the moderate speed mixer/densifier to facilitate and control agglomeration.
Patent DE-69516687-D1 (DE)
Inventor: KLOFTA JAMES
IPC: D21H17/20
Filed: 1995-05-23
Granted: 2000-06-08
Abstract: A lotion composition for imparting a soft, lubricious, lotion-like feel when applied to tissue paper in amounts as low as from about 5 to about 15% by weight, and tissue paper treated with such lotion compositions are disclosed. The lotion composition comprises plastic or fluid emollient such as petrolatum, or a mixture of petrolatum with alkyl ethoxylate emollient, an immobilizing agent such as a fatty alcohol or fatty acid to immobilize the emollient on the surface of the tissue paper web and optionally a hydrophilic surfactant to improve wettability when applied to toilet tissue. Because less lotion is required to impart the desired soft, lotion-like feel benefits, detrimental effects on the tensile strength and caliper of the lotioned paper are minimized or avoided.
Patent DE-69526332-D1 (DE)
Inventor: MACHII DAISUKE
IPC: C07D209/42
Filed: 1995-01-11
Granted: 2002-05-16
Abstract: The present invention relates to indole derivatives represented by formula (I): <CHEM> wherein R<1> and R<2> independently represent hydrogen, lower alkyl, -(CH2)n-OR<6> (wherein R<6> represents hydrogen or lower alkyl, and n is an integer of 1 to 6), or <CHEM> (wherein R<7> and R<8> independently represent hydrogen or lower alkyl, or R<7> and R<8> are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted alicyclic heterocyclic group, and m represents an integer of 2 to 6), R<3> represents hydrogen, lower alkyl, or <CHEM> (wherein R<9> and R<10> independently represent hydrogen or lower alkyl, or R<9> and R<10> are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted alicyclic heterocyclic group, and p represents an integer of 2 to 6), R<4> and R<5> independently represent hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclic group, or R<4> and R<5> are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted alicyclic heterocyclic group, or pharmaceutically acceptable salts thereof.
Patent DE-69532140-D1 (DE)
Inventor: EDWARDS STUART D
IPC: A61M1/00
Filed: 1995-08-11
Granted: 2003-12-18
Abstract: A tissue ablation apparatus includes a delivery catheter with distal and proximal ends. A handle is attached to the proximal end of the delivery catheter. At least partially positioned in the delivery catheter is an electrode deployment device. The electrode deployment device includes a plurality of retractable electrodes. Each electrode has a non-deployed state when it is positioned in the delivery catheter. Additionally, each electrode has a distended deployed state when it is advanced out of the delivery catheter distal end. The deployed electrodes define an ablation volume. Each deployed electrode has a first section with a first radius of curvature. The first section is located near the distal end of the delivery catheter. A second section of the deployed electrode extends beyond the first section, and has a second radius of curvature, or a substantially linear geometry. <IMAGE>
Patent DE-69533299-D1 (DE)
Inventor: SATO YASUSHI
IPC: B41J5/30
Filed: 1995-05-30
Granted: 2004-09-02
Abstract: A printing control apparatus comprises a plurality of interfaces for receiving input data from a host computer; and a plurality of data conversion means for converting the input data received from the host computer into code data that can be interpreted by a printing apparatus; characterized by discriminating means for discriminating whether one of the plurality of data conversion means is a candidate for or at least two of the plurality of data conversion means are candidates for one of the plurality of interfaces which receives the input data; selection means for, if said discrimination means discriminates that at least two of the plurality of data conversion means are candidates for the one interface, analyzing commands included in the input data and for, based on the analyzed commands, selecting one of the at least two data conversion means; and printing control means for effecting data conversion, wherein said printing control means is adapted to use, if said discrimination means discriminates that one of the plurality of data conversion means is a candidate for the one interface, the one data conversion means, and said selection means is adapted to select, if said discrimination means discriminates that at least two of the plurality of data conversion means are candidates for the one interface, the one of the at least two data conversion means and said printing control means is adapted to use the selected one data conversion means.
Patent DE-69535752-D1 (DE)
Inventor: BAETSCHER MANFRED W
IPC: A61K35/12
Filed: 1995-03-31
Granted: 2008-06-26
Abstract: Transgenic swine in which the normal expression of alpha(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galalpha1-3Galbeta1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
Patent DE-69605668-D1 (DE)
Inventor: BODOR JANOS
IPC: A23C20/00
Filed: 1996-05-22
Granted: 2000-01-20
Abstract: A process for preparing a processed-cheese type product having a crumbly texture that is free of polysaccharide texturing agent and gelatin, including the steps of: a) preparing an aqueous composition comprising milk protein, containing milk protein and water in a weight ratio of from 1:2 to 1:10, wherein the pH is caused to be 4.4-5.0 to cause precipitation of protein; b) incorporating emulsifying salts to cause an increase in pH and to obtain a pH of 4.8-5.3; c) subjecting the mixture to a heat treatment at least sufficient to pasteurize it and passing it through a homogenizer; and d) packing the resulting mixture at a tempeature of at least 65  DEG C, provides a product with a crumbly texture like fresh cheese or white cheese while it has the keepability typical of processed cheeses. As milk protein source, materials with good keepability can be employed. Use of cheese as starting material is not required. Also provided is such a product with crumbly texture and good keepability, having St10 value of 150-1500 g and pH of 4.8-5.3 that is free of polysaccharide texturing agent and gelatin. The product comprises 0-65 % dispersed fat phase and 35-100 % continuous aqueous phase, the aqueous phase containing milk protein and water in a weight ratio of 1:2 to 1:10. The dissolved protein content is less than 40 % calculated on the total amount of protein.
Patent DE-69606382-D1 (DE)
Inventor: CABIOCH JEAN-LUC
IPC: B60C1/00
Filed: 1996-10-16
Granted: 2000-03-02
Abstract: Vulcanisable rubber composition comprising functionalised dienic polymer(s) and silica as a reinforcing filler comprises dienic polymer carrying, at the end of the chain, a silanol function or a polysiloxane block with silanol at one end and silica in the majority part. Also claimed are: (i) a pneumatic tyre tread made using the composition; (ii) a process (A) for obtaining dienic polymer with a silanol function or a polysiloxane block with a silanol group; and (iii) a process (B) for obtaining a dienic copolymer with a polysiloxane block.
Patent DE-69606627-D1 (DE)
Inventor: DROUAULT GUY
IPC: A61K33/14
Filed: 1996-03-12
Granted: 2000-03-16
Abstract: PCT No. PCT/FR96/00382 Sec. 371 Date Sep. 12, 1997 Sec. 102(e) Date Sep. 12, 1997 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/28172 PCT Pub. Date Sep. 19, 1996Pharmaceutical compositions for regulating unitary smooth muscle polarization containing aqueous solutions based on magnesium, potassium, sodium and optionally calcium salts, at least one sugar and at least one amino acid, combined with a copper salt or a zinc salt. The invention further relates to a kit containing at least two of these pharmaceutical compositions.
Patent DE-69616439-D1 (DE)
Inventor: PERSSON MICHAEL
IPC: C08L79/02
Filed: 1996-06-14
Granted: 2001-12-06
Abstract: The invention relates to a process for the production of paper from a suspension of cellulose containing fibres, and optional fillers, wherein a low molecular weight cationic organic polymer, a high molecular weight cationic or amphoteric polymer and anionic inorganic particles are added to the suspension and the suspension is formed and drained on a wire, wherein the low molecular weight polymer has a molecular weight below 700,000, the high molecular weight polymer has a molecular weight above 1,000,000 and said polymers are simultaneously added to the suspension. The invention further relates to a polymer mixture in the form of an aqueous dispersion comprising at least one high molecular weight cationic or amphoteric acrylamide-based polymer having a molecular weight above 1,000,000, at least one low molecular weight cationic organic polymer having a molecular weight below 700,000 and at least one water-soluble inorganic salt, wherein the weight ratio of said high molecular weight polymer to said low molecular weight polymer is within the range of from 9:1 to 1:2.
Patent DE-69626819-D1 (DE)
Inventor: PANCHERI JOSEPH
IPC: C11D3/10
Filed: 1996-04-23
Granted: 2003-04-24
Abstract: The invention provides cleaning compositions containing a builder material which has substantially improved performance and is significantly less expensive than previous builders. The builder material has improved performance in that it unexpectedly has a high calcium ion exchange capacity and rate, and is easy to handle, process and disperse in washing solutions. The cleaning compositions contain a builder material having at least one crystalline microstructure including a carbonate anion, calcium cation and at least one water-soluble cation. The microstructure should have a sufficient number of anions and cations so as to be "balanced" or "neutral" in charge.
Patent DE-69626992-D1 (DE)
Inventor: GREFF J
IPC: A61L24/00
Filed: 1996-07-29
Granted: 2003-04-30
Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10  mu m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.
Patent DE-69635193-D1 (DE)
Inventor: TSIEN ROGER Y
IPC: C07F9/10
Filed: 1996-06-06
Granted: 2005-10-20
Abstract: Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane, as described by the Nernst equation, (b) introducing a second reagent which labels the first face or the second face of the membrane, which second reagent comprises a chromophore capable of undergoing energy transfer by either (i) donating excited state energy to the fluorescent ion, or (ii) accepting excited state energy from the fluorescent ion, (c) exposing the membrane to radiation; (d) measuring energy transfer between the fluorescent ion and the second reagent, and (e) relating the energy transfer to the membrane potential. Energy transfer is typically measured by fluorescence resonance energy transfer. In some embodiments the first and second reagents are bound together by a suitable linker. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes.
Patent DE-69717301-D1 (DE)
Inventor: JOHANNSSON GUDMUNDUR
IPC: A61P9/00
Filed: 1997-04-10
Granted: 2003-01-02
Abstract: The invention relates to the use of growth hormone, preferably human growth hormone or analogues thereof for the manufacturing of a medicament for treatment of individuals with the Metabolic syndrome. They include individuals with abdominal/visceral obesity and its metabolic and circulatory consequences including insulin resistance, lipoprotein aberrations and hypertension. The medicament is also used to increase insulin sensitivity and for treatment and prevention of non-insulin dependent diabetes mellitus.
Patent DE-69720718-D1 (DE)
Inventor: CHEN ZHULIANG
IPC: A61K31/38
Filed: 1997-01-30
Granted: 2003-05-15
Abstract: A compound having the structure:   <IMAGE>   wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl or aralkyl having from 1 to about 3 carbon atoms; or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) R1 and R2 are each independently hydrogen or straight, branched or cyclic alkyl, unsubstituted or substituted, carboxyl, carboxamido, alkoxycarbonyl or alkylcarbonyl; and (f) Het is a heteroaryl group comprising one or more rings containing from about 5 to about 8 atoms in the rings and wherein at least one ring has at least one heteroatom selected from O, N, or S, pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Patent DE-69726734-D1 (DE)
Inventor: REISNER YAIR
IPC: A01K67/027
Filed: 1997-06-10
Granted: 2004-01-22
Abstract: Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines, and antibodies produced by the cell lines. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are engrafted into normal strains of mice which were lethally irradiated and radioprotected with SCID bone marrow. After immunization of such chimeric mice with HBVsAg, human cells are obtained from the mice spleens and fused in vitro with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.
Patent DE-69730688-D1 (DE)
Inventor: METZIGER PIERRE
IPC: A61P25/00
Filed: 1997-06-30
Granted: 2004-10-21
Abstract: PCT No. PCT/EP97/03405 Sec. 371 Date Mar. 3, 1998 Sec. 102(e) Date Mar. 3, 1998 PCT Filed Jun. 30, 1997 PCT Pub. No. WO98/01118 PCT Pub. Date Jan. 15, 1998Pharmaceutical compositions for oral administration are disclosed containing a medicinal product that is insoluble or sparingly soluble in water and oils selected from diacerein, rhein and one of their pharmaceutically acceptable salts.
Patent DE-69734884-D1 (DE)
Inventor: FINSTERLE LUCA GUBERT
IPC: H04R1/40
Filed: 1997-08-05
Granted: 2006-01-19
Abstract: A two-channel sound recording and play-back system for providing a holophonic reproduction or play-back of sounds is herein disclosed. The two-channel recording system comprises cables and electronic apparatus for providing a stereophonic type of recording, where a plurality of microphones are arranged in an adjoining mutually angled relationship so as to provide, during the recording operation, a stereophonic effect due to phase differences at each frequency and an intensity difference at least for middle-high acoustic frequencies. The two-channel sound play-back system comprises, in addition to a source and a two-channel amplifying system, a plurality of diffusers arranged to corners of a parallelogram, a listening point being preferably arranged at the center of said parallelogram, the front or rear diffusers receiving the recorded signal without modifications, whereas, respectively, the rear or front diffusers receive a signal the sound pressure of which is adjusted, by a perspective corrector, from -15 dB to +9 dB, as modified in the frequency response thereof and with a delayed emission, so as to broaden the sound range up to 360°, thereby providing a sound holophonic play-back.
Patent DE-69736493-D1 (DE)
Inventor: BANKS GERALD J
IPC: G11C11/56
Filed: 1997-12-11
Granted: 2006-09-21
Abstract: Memory states of a multi-bit memory cell are demarcated by generating read reference signals having levels that constitute boundaries of the memory states. The read reference signals are dependent upon the levels of programming reference signals used for controlling the programming of the memory cell. The memory cell can thus be programmed without reading out its memory state during the programming process, with programming margins being assured by the dependence of the read reference signals on the programming reference signals. Both pets of reference signals may be generated by reference cells which track variations in the operating characteristics of the memory cell with changes in conditions, such as temperature and system voltages, to enhance the reliability of memory programming and readout.
Patent DE-69803174-D1 (DE)
Inventor: LAUTERWALD MARTIN
IPC: B23B45/16
Filed: 1998-03-31
Granted: 2002-02-21
Abstract: A rotary hammer comprises an electric motor having its longitudinal axis perpendicular to the axis of the hammer spindle and the tool holder. A single switching element activates and deactivates the hammer mechanism and the rotary drive for the tool holder. The switching element has an eccentric actuating section extending parallel to the main axis of the switching element, acting on a coupling part to activate and deactivate the hammer drive. The switching element has a cam section acting on a slider part to engage and disengage a coupling sleeve (non-rotatable on the hammer spindle) with a drive sleeve to thereby engage and disengage the rotary drive of the hammer spindle.
Patent DE-69813731-D1 (DE)
Inventor: DOUVEN FERDINAND
IPC: B26B19/38
Filed: 1998-01-29
Granted: 2003-05-28
Abstract: A shaving apparatus has a head assembly (2) which houses rotary cutters (8), and guards (4) which are provided with an annular series of hair-entry apertures (6). A fixed supporting surface is provided inside and outside the ring of apertures, to provide support when shaving with large applied pressure.
Patent DE-69826984-D1 (DE)
Inventor: SANTOS NERI JOSE LUIS
IPC: G04B37/10
Filed: 1998-01-19
Granted: 2004-11-18
Abstract: This invention relates to a rubber plate (elastic) (FIG.1) which, when soldered at its edges (FIG. 1A) to the inside of the body (case) of a watch (or other object) (FIG. 3A), totally seals it against water and dust. At the same time, in view of the fact that it is soldered at its sides (edges), its central part remains totally free, thus permitting the movement of the outside control buttons (FIG. 4C, D and 6A) and activating the mechanism, whether it is electronic (FIG. 3D) or mechanical (FIG. 5 and 7) (digital or analog). When the external controls are pressed, the corresponding function is switched on internally (FIG. 4E, F). A single plate (FIG. 3A) can be used for various controls (FIG. 3B, C) or one plate for each control (FIG. 4A, B), depending on the distance between them and the space available in the watch-case. This system, which involves extremely low costs, is not exclusive to watches and can be used for any instrument that is intended to be placed in deep water or where a lot of dust is present (or non-corrosive liquids), for example stopwatches, cameras, video cameras, floodlights, underwater weapons, etc., without the risk of any penetration, even at a great depth.
Patent DE-69828635-D1 (DE)
Inventor: BURNSIDE A
IPC: A61K38/095
Filed: 1998-09-18
Granted: 2005-02-17
Abstract: Disclosed is a beadlet comprising (i) a hydrophobic long chain fatty acid or ester material; (ii) a surfactant; and (iii) a therapeutic agent which in admixture form a solid solution at room temperature. The hydrophobic material preferably has a melting point of about 40 to about 100° C., and is most preferably glyceryl behenate. The surfactant is preferably a polyglycolyzed glyceride, polyoxyethylene sorbate, ethylene or propylene block copolymer or combinations thereof, and is most preferably polyoxyethylene 20 sorbitan monolaurate.
Patent DE-69835215-D1 (DE)
Inventor: LU PING
IPC: A61K38/00
Filed: 1998-09-04
Granted: 2006-08-24
Abstract: Inhibitors of phosphoserine- or phosphothreonine-specific pepidyl prolyl isomerases are described.