baber/WOPTO huggingface dataset:
Patent CA-2902210-A1 (CA)
Title: Chemical crosslinkers
Inventor: DO HUNG
IPC: A61K38/47
Filed: 2014-03-14
Abstract: Disclosed herein are methods of chemical conjugation comprising contacting a lysosomal enzyme with a first crosslinking agent to introduce aldehyde groups; contacting a lysosomal targeting peptide with a second crosslinking agent to introduce a hydrazide group at the N-terminal residue; contacting the lysosomal enzyme with aldehyde groups of step a. with the lysosomal targeting peptide with a hydrazide group at the N-terminal residue of step b; and forming a lysosomal enzyme-lysosomal targeting peptide conjugate.
Patent CA-2903841-A1 (CA)
Inventor: DOMS JAN
IPC: G06F17/30
Filed: 2015-09-10
Abstract: When handling a request for data of at least one key: -    providing this request to a predetermined shard store; -    this predetermined shard store verifying, by means of its local subrange collection, whether this at least one key is present in a local subrange of a shard stored on this predetermined shard store; and -    when at least one key is not present in a local subrange of a shard stored on this predetermined shard store, returning a message comprising the local subrange collection of this predetermined shard store.
Patent CA-2903970-A1 (CA)
Inventor: RUCMAN RUDOLF
IPC: A61K38/17
Filed: 2013-05-09
Abstract: L'invention concerne de nouveaux sels pentadécapeptides stables, un procédé de préparation de ceux-ci, leur utilisation dans la fabrication de préparations pharmaceutiques et leur utilisation en thérapie. La présente invention concerne de nouveaux sels pentadécapeptides stables de formule (I) : Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val · n BAA 1 5 10 15 SEQ ID NO:1 (I) où n signifie 1, 2 ou 3, et BAA signifie un acide aminé basique, un procédé de préparation associé, un procédé d'utilisation de ceux-ci pour la fabrication de formulations pharmaceutiques sous forme liquide et solide et leur utilisation pour la prévention, la protection dans le traitement de maladies et d'états maladifs et pour la préparation de formulations en vue de l'utilisation en tant que compléments alimentaires.
Patent CA-2907980-A1 (CA)
Inventor: SCHROFF MATTHIAS
IPC: G01N33/50
Filed: 2014-05-15
Abstract: The present invention relates generally to the identification of patients suffering from cancer whether they will respond to specific therapies. More particularly the invention relates to a method and means for identifying responder to a therapy TLR-9 agonists.
Patent CA-2908096-A1 (CA)
Inventor: JASCHINSKI FRANK
IPC: A61K31/713
Filed: 2014-03-27
Abstract: L'invention concerne un oligonucléotide consistant en 10 à 20 nucléotides de régions sélectionnées de la séquence d'acide nucléique TGF-bêta1, TGF-bêta2 ou TGF-bêta3, qui comprend des nucléotides modifiés tels que les nucléotides modifiés LNA, ENA, poly(oxyde d'alkylène), 2'-fluoro, 2'-O-méthoxy et/ou 2'-O-méthyle. Les régions sélectionnées sont de préférence la région d'acide nucléique no 1380 à 1510, no 1660 à 1680, no 2390 à 2410 ou no 2740 à 2810 de la séquence d'acide nucléique TGF-bêta2 de SEQ ID NO 1, des régions spécifiques de la séquence d'acide nucléique TGF-bêta1 de SEQ ID NO 149 ou des régions spécifiques de la séquence d'acide nucléique TGF-bêta3 de SEQ ID NO 267. L'invention concerne en outre des compositions pharmaceutiques comprenant un tel oligonucléotide, la composition ou l'oligonucléotide étant utilisé dans la prévention et/ou le traitement d'une tumeur maligne et/ou bénigne, d'une maladie immunologique, de la fibrose, du glaucome, etc.
Patent CA-2909146-A1 (CA)
Title: Dispositif d'alimentation en combustible a deux phases pour chaudieres
Inventor: DESELLEM JAMES F
IPC: F23C10/10
Filed: 2014-04-07
Abstract: L'invention concerne un dispositif d'alimentation en combustible à deux phases pouvant être utilisé pour fournir à la fois des combustibles solides et des combustibles liquides à une chaudière, telle qu'une chaudière à lit fluidisé. Le dispositif d'alimentation en combustible comprend une chute en pente qui définit un chemin d'alimentation solide. Des buses de distribution de gaz sont situées sur la base du dispositif d'alimentation en combustible, et des buses secondaires sont situées de façon à pouvoir distribuer un combustible liquide ou particulaire dans le chemin d'alimentation en solides, ce qui permet au combustible liquide d'entrer en contact avec le combustible solide et d'être transporté dans le lit fluidisé au lieu d'être en suspension au-dessus du lit.
Patent CA-2912216-A1 (CA)
Title: Measures of short telomere abundance
Inventor: HARLEY CALVIN
IPC: C12Q1/68
Filed: 2014-05-22
Abstract: This invention provides methods and materials for measuring telomere abundance from chromosomes in a sample having telomeres within a pre-determined length range, e.g., short telomeres up to a certain length. The methods can involve a first step of performing a time- limited extension reaction calibrated to produce extension products from a double-stranded chromosomal DNA template of no more than a defined length, and a second step of amplifying, from the extension products, sequences bounded by a sub-telomeric sequence and the anchor sequence, to produce a length-limited telomere sequence product. The abundance of telomeric sequences in this product can be measured, and the measures can be correlated to a variety of indices.
Patent CA-2912990-A1 (CA)
Inventor: MEI LUCIANO
IPC: F04D29/059
Filed: 2014-05-29
Abstract: The rotating machine comprises a shaft 14, a casing 12, at least one main magnetic bearing 16 connected to the shaft for rotatably supporting said shaft inside the casing, at least one auxiliary radial rolling bearing 18 and at least one auxiliary axial rolling bearing 22 which are disposed between the shaft and the casing to respectively support radial loads only and axial loads only.
Patent CA-2913857-A1 (CA)
Title: Pre-distancing collapsible system particularly for the elements of a structural frame
Inventor: SICA MAURO
IPC: E04C2/38
Filed: 2014-06-03
Abstract: The present invention refers to a pre-distancing collapsible system particularly for the elements of a structural frame of a building. An embodiment of the invention comprises at least three components of a structural frame and at least two spacers, not being these spacers structural elements of the frame, fastened to the heads of aforementioned components of the frame, and said spacer being foldable.
Patent CA-2917560-A1 (CA)
Inventor: ROSS STEVEN ALAN
IPC: F01D19/00
Filed: 2016-01-14
Abstract: A method of starting a gas turbine engine having a rotor comprising at least a shaft mounted compressor and turbine, with a casing surrounding the rotor.
Patent CA-2917873-A1 (CA)
Inventor: STAIR TODD ANTHONY
IPC: E21B34/06
Filed: 2013-09-11
Abstract: A check valve is provided having a magnetic plug and a magnetic seat. The magnetic seat and magnetic plug operationally engage so as to have a magnetic resistivity such that there is a first position in which the magnetic plug does not sealingly engage the magnetic seat and a second position where the magnetic plug is sealingly engaged with the magnetic seat.
Patent CA-2920640-A1 (CA)
Inventor: EKEVAD MATS
IPC: B27B7/00
Filed: 2014-07-07
Abstract: Method (500) and calculating unit (620) for curve sawing of a block (100) in a cutting direction (S) with at least a first circular saw blade (110). The method (500) comprises determining (501) a radius (R) of the curve sawing, by measuring the curvature of the block (100) in the direction of cutting (S); calculating (502) a vertical inclination angle (ß) of the first circular saw blade (110) in a vertical plane (V) relative to the cutting direction (S) in the block (100), based on the determined radius (R) of the curve sawing; inclining (503) the first circular saw blade (110) with the calculated (502) vertical inclination angle (ß); and sawing (508) the block (100) in the cutting direction (S) with the inclined (503) first circular saw blade (110) along the determined (501) radius (R) of the curve sawing.
Patent CA-2921231-A1 (CA)
Title: Systems and methods for in silico evaluation of polymers
Inventor: KISIEL KAMIL
IPC: C12Q1/68
Filed: 2014-07-14
Abstract: Systems and methods for evaluating a polymer make use of a workflow request identifying input data and a workflow instance. The workflow instance comprises a plurality of actors, each having one or more input and output ports. The workflow instance defines an acyclic directed graph comprising nodes and edges. Each node is an actor in the plurality of actors and each edge corresponds to at least one of (i) an input port of an actor in the plurality of actors and (ii) an output port of an actor in the plurality of actors. Graph parsing produces an ordered list of job requests. Each job request corresponds to an actor in the plurality of actors. An actor in the plurality of actors is executed in an order specified by the ordered list and contributes an output to another actor in the plurality of actors that is specified by the graph.
Patent CA-2922589-A1 (CA)
Title: Reduction of epileptic seizures
Inventor: STROH PLAMENA RUMYANOVA
IPC: A61K31/19
Filed: 2014-07-18
Abstract: ABSTRACT Compositions for use in treatment of epilepsy or an epilepsy-related disorder, are provided.  Uses of the compositions for treatment of epilepsy or an epilepsy-related disorder are also described, along with methods for employing the compositions. The described compositions reduce the frequency and severity of epileptic seizures. Date recue/Date Received 2020-11-30
Patent CA-2922616-A1 (CA)
Title: Systeme d'aide au pilotage d'un aeronef et procede
Inventor: LEPAGE SEBASTIEN
IPC: B64C13/18
Filed: 2016-03-03
Abstract: Linvention concerne un système daide au pilotage (3) pour un aéronef (5) en pilotage manuel, lequel système comprend un module de surveillance (50), configuré pour comparer une accélération de laéronef (5) à une accélération autorisée qui dépend dune vitesse de laéronef (5), un module de commande d'accélération (52), capable de passer dun état activé à un état désactivé, et configuré de sorte que, dans létat activé, mais pas dans létat désactivé, il génère un signal de commande à partir dau moins un dispositif de commande (7, 9, 11, 13, 17) de laccélération de laéronef (5) pour pousser laccélération de laéronef (5) vers ladite plage d'accélération autorisée, afin de maintenir ou daugmenter la vitesse de laéronef (5) dans une plage de vitesse dusage prédéfinie, ledit module de surveillance (50) étant configuré pour activer ledit module de commande d'accélération (52) lorsque laccélération de laéronef (5) ne sinscrit pas dans ladite plage d'accélération autorisée.
Patent CA-2922908-A1 (CA)
Title: Retaining device having hooks
Inventor: MAHE ANTHONY
IPC: B60N2/58
Filed: 2014-09-01
Abstract: The invention relates to a retaining device (100) having hooks, which is suitable for defining at least a portion of a receiving groove formed at the periphery of an object and which includes a retaining element (10) produced by injection molding. The retaining element comprises a first side wall (11) and a second side wall (12), which are spaced apart from one another in a side direction, and a base (20) connecting said side walls (11, 12) to one another therebetween. The side walls (11, 12) and the base (20) define a retaining groove (14) open in a main direction (z) for receiving a counterpart having hooks or loops. According to the invention, at least one of the side walls (11, 12) has a plurality of hooks (30) suitable for engaging with the counterpart, each hook (30) comprising at least one useful hooking portion oriented toward the base (20) of the retaining element (10).
Patent CA-2924250-A1 (CA)
Title: System and method for washing items
Inventor: HANSSON PER
IPC: D06F39/10
Filed: 2014-09-08
Abstract: A system(10) for washing items(12)with water, comprising a water inlet (18) and a container (13) for receiving the items(12)to be washed. The system (10) comprises a water purification apparatus (19) for purifying water intro- duced through said water inlet (18) to produce purified water. The water puri- fication apparatus (19) comprises at least one filter (25, 29, 30) for filtering off particulate solids, a reverse osmosis device (26), andat least one deionizing filter (27, 31). The system(10) further comprises a reservoir (20) for storing purified water produced by the water purification apparatus (19), said reser- voir (20) being connected to said water purification apparatus (19) and said container (13), so that the items (12) are washable inside the container (11) with the purified water. Disclosed is also a method for washing items.
Patent CA-2925455-A1 (CA)
Title: Content supplying apparatus, content supplying method, program, terminal device, and content supplying system
Inventor: YAMAGISHI YASUAKI
IPC: H04N21/6437
Filed: 2014-09-12
Abstract: The present disclosure relates to a content supply device, a content supply method, a program, a terminal device, and a content supply system which make it possible to notify the receiving side of a correspondence relationship between a FLUTE stream and a segment stream. This content supply device is provided with: a FLUTE stream generation unit which generates a FLUTE stream from a fragment stream, and generate an SDP by describing information relating to a FLUTE session for delivering the FLUTE stream, and information relating to the MPD in which information required for the receiving side to acquire the fragment stream corresponding to the FLUTE stream is described; and a multicast delivery unit which performs FLUTE multicast delivery of the FLUTE stream and the SDP. The present disclosure is applicable to a system which performs FLUTE multicast delivery of a content.
Patent CA-2928527-A1 (CA)
Inventor: SCHWEICH CYRIL J JR
IPC: A61B17/00
Filed: 2014-10-22
Abstract: Systems and methods for medical interventional procedures, including approaches to valve implantation. In one aspect, the methods and systems involve a modular approach to mitral valve therapy.
Patent CA-2930681-A1 (CA)
Inventor: MATSUSHITA OSAMU
IPC: A61P35/04
Filed: 2008-04-09
Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Patent CA-2933721-A1 (CA)
Inventor: BARTOS THOMAS M
IPC: C07C51/255
Filed: 2014-12-11
Abstract: Procédé amélioré de préparation d'acides carboxyliques aromatiques par réaction d'oxydation en phase liquide exothermique d'un composé de charge aromatique, de l'eau étant efficacement récupérée de la réaction d'oxydation en phase liquide exothermique et traitée pour réduire des agents corrosifs s'y trouvant.
Patent CA-2934142-A1 (CA)
Title: Dispositif de distribution de boisson pour distribuer differents types de boissons ou constituants de boisson
Inventor: PEIRSMAN DANIEL
IPC: B67D1/00
Filed: 2014-12-19
Abstract: L'invention concerne un dispositif de distribution de boisson (1) pour distribuer différents types de boissons ou constituants de boisson (4, 6, 8), dont au moins l'un est une boisson ou un constituant de boisson à base de malt, qui comprend de multiples conduites d'alimentation (9) s'étendant chacune à partir d'une source d'alimentation correspondante (2) et comprenant une valve de conduite d'alimentation régulable (10) ainsi qu'un moyen de commande (19) pour régler séquentiellement les valves de conduite d'alimentation régulables (10), une boisson (24) contenant de multiples boissons ou constituants de boisson (4, 6, 8) étant distribuée dans un réceptacle (14) lorsque chaque étape de séquence a été exécutée, et ce pendant un cycle de soutirage unique.
Patent CA-2936383-A1 (CA)
Inventor: ROMERO RAUL
IPC: E01C23/16
Filed: 2016-07-15
Abstract: A ground surface marking system including a beam transmitter configured to emit electromagnetic radiation and a distal target. The distal target is oriented to be impacted along a first target surface by at least a portion of the electromagnetic radiation.  The distal target is mounted on a target stand configured for adjustment with respect to a vertical axis. The system also includes a target applicator having a second target surface, a base including a shaft, and a container attached to the base and configured to hold and dispense markers for placement along the ground surface extending between the beam transmitter and the distal target.
Patent CA-2937626-A1 (CA)
Inventor: ANTHONY DEVEN J
IPC: H04L9/08
Filed: 2016-07-28
Abstract: Systems and methods for managing cryptographic keys in an avionic data transfer system are provided. A host device (110) associated with the avionic data transfer system can receive one or cryptographic keys (115) via a key fill interface. For instance, in one embodiment, the host device (110) can receive one or more cryptographic keys (215) from a removable data cartridge (130). The host device (110) can act as a key server for other cryptographic units (115) associated with the avionic data transfer system via a data bus (118). For instance, the host device (110) can distribute one or more cryptographic keys (215) to other cryptographic units (115) associated with aircraft via an aircraft bus. The other cryptographic units (115) can use the one or more cryptographic keys (215) for cryptographic processing of data.
Patent CA-2939304-A1 (CA)
Title: Modeles d'extraction d'info d'image universelle a base de pixels et flux de processus
Inventor: WANG ZHE JUN
IPC: G06T7/00
Filed: 2016-08-17
Abstract: Une image numérique est constituée de pixels, et la couleur de chaque pixel est composée de trois couleurs primaires (Rouge, Vert et Bleu). Chacune des couleurs primaires peut se subdiviser en 256 niveaux, et en combinant tous ces niveaux, on peut obtenir 256 × 256 × 256 couleurs. La manière de déterminer et dextraire de linformation utile sur les couleurs constitue le principal sujet de la présente demande. Par la sélection manuelle dune même sorte de pixels types sur limage, on arrive à limiter les seuils respectifs des couleurs primaires Rouge, Vert et Bleu, à calculer le rapport entre les couleurs primaires, à établir les modèles et les paramètres dextraction dinformation linéaire et non linéaire décrits dans la présente divulgation, et, ainsi, à comparer et à analyser les autres pixels de limage au moyen de ces modèles établis. Lextraction rapide de linformation utile est achevée. La présente demande fournit également un modèle dextraction dinformation dhistogramme, des modèles de correction de couleurs caractéristiques et un modèle dédition multirégional. Les modèles dextraction décrits dans cette demande peuvent être utilisés par des industries variées, y compris sans toutefois sy limiter, la télédétection, la météorologie et la géologie.
Patent CA-2939816-A1 (CA)
Title: Production of curved preforms
Inventor: STAHL ARNE
IPC: B29B11/16
Filed: 2015-02-26
Abstract: The invention relates to a device (1) for producing a curved preform (9) from flat semi-finished fiber material (8), comprising a shearing unit (2), which has at least two rotating rolling elements (3a, 4a), arranged spaced apart in a conveying direction (11), and a control unit (6) connected to the rolling elements, wherein at least one of the rolling elements is formed in a pivotal or tilting manner and a semi-finished fiber material sensing device (7) is provided, which is formed for sensing position information of the semi-finished fiber material conveyed through the shearing unit, wherein the control unit is further arranged for pivoting or tilting the at least one rolling element during the conveyance of the semi-finished fiber material, depending on the sensed position information from the semi-finished fiber material sensing device.
Patent CA-2940745-A1 (CA)
Inventor: GEIGER JOHN ANDREW
IPC: H04W84/18
Filed: 2015-02-24
Abstract: L'invention porte sur un système, qui comprend un routeur de bord qui collecte des données à partir d'un réseau maillé par la réception sur de multiples fréquences simultanées. L'utilisation de N fréquences simultanées augmente le débit de sortie d'un système jusqu'à N fois, réduisant le goulot d'étranglement qui se produit, sinon, au point de sortie d'un système de communications maillé. De plus, des nuds en communication directe avec le routeur de bord peuvent chacun envoyer un paquet de données de multiples fois sur de multiples fréquences, ce qui augmente la probabilité pour que le paquet soit délivré correctement, et ce qui élimine la nécessité d'accuser réception (ACK) de chaque paquet. Ceci améliore encore davantage le débit de sortie du système.
Patent CA-2942719-A1 (CA)
Title: Scale collection and predistribution tray for vessel with downward two-phase flow
Inventor: MULLER MORTEN
IPC: B01J8/02
Filed: 2015-03-13
Abstract: Vapor and liquid flow concurrently down through a vertical vessel. A horizontal scale collection and predistribution tray is located in the vessel to remove solid contaminants and to redistribute the liquid to a fine distribution tray. The scale collection and predistribution tray consists of a tray plate with a scale collection zone where the solid contaminants settle and deposit. In one embodiment, an upstanding permeable wall forms the scale collection zone, and liquid is filtered as it flows through the permeable wall, leaving the solid contaminants trapped upstream from the permeable wall. The predistribution tray has a rim provided with a slotted weir. Liquid from the scale collection zone forms a liquid level in a trough located between the permeable wall and the weir. Due to the uniform liquid level in the trough, liquid flow rates through the slots in the weir are nearly equal. Because of the polygonal shape of the tray, the liquid exits the slots in a direction along lanes defined between distribution units on the fine distribution tray, and the amount of liquid entering the vapor inlets of the distribution units is therefore small. Vapor by-passes the scale collection and predistribution tray through the area between the reactor wall and the permeable wall, and through the area between the reactor wall and the weir to the fine distribution tray. The scale collection and predistribution tray protects the fine distribution tray and the catalyst bed from fouling, predistributes liquid to the fine distribution tray to minimize level gradients on this tray, and reduces flow velocities to ensure calm flow conditions on the fine distribution tray.
Patent CA-2944121-A1 (CA)
Title: Engine bore milling process
Inventor: STEPHENSON DAVID ALAN
IPC: B23C3/02
Filed: 2016-10-04
Abstract: A method of milling an engine bore is disclosed. The method may include inserting a milling tool having a plurality of cutting edges along a longitudinal axis into an engine bore, rotating the milling tool about the longitudinal axis and moving the milling tool around a perimeter of the engine bore to remove material from the engine bore, and rough honing the bore.  The milling may generate a tapered bore (e.g., frustoconical). The rough honing process may increase a minimum diameter of the tapered bore by at least 60 µm. A total time of the milling and honing process may be less than 60 seconds. In one embodiment, the honing step may include using a grit size of at least 200 µm and/or using a honing force of at least 200 kgf. The method may reduce the cycle time and tooling requirements of forming engine bores.