Patent GB-570428-A (GB)
Title: Improvements in surgical dressings of sulphonamides
IPC: A61L15/28
Filed: 1943-06-28
Abstract: A surgical dressing particularly for burns comprises a preformed self-supporting film containing a water soluble cellulose derivative, a plasticizer and a bacteriostatic sulphonamide, or a textile material on which the above substances have been deposited, as by spraying or dipping.  The film itself may be formed by spraying or casting an aqueous solution or suspension of the film-forming ingredients.  Typical solutions for spraying contain 3 per cent of 2-sulphanilamidopyrimidine, 2 per cent dimethyl cellulose and either 2 per cent sorbitol, 1 per cent triethanolamine and 0.5 per cent wetting agent or 4 per cent propylene glycol and 0.5 per cent wetting agent.  A third solution contains 3 per cent each of methyl cellulose and the sulphonamide, 8 per cent triethanolamine, 0.5 per cent wetting agent and 0.2 per cent sorbitol.  Cellulose derivatives specified are methyl- or ethyl-cellulose ethers, hydroxyethyl cellulose, hydroxyethylmethyl cellulose, ethyl cellulose acetate, methyl cellulose propionate, hydroxyethyl cellulose butyrate, alkali metal salts of cellulose glycollic acid.  The term bacteriostatic sulphonamide includes sulphanilamide, 2-sulphanilamidothiazole, 2-sulphanilamidopyrimidine, 2-sulphanilamidopyridine, disulphanilamide and the various N1-sulphonilamides, such as N1-dodecanoylsulphanilamide, as well as the water soluble (especially sodium) and water-insoluble salts of the above compounds. Plasticizers include glycerin, sorbitol, mannitol, invert sugar solution, propylene glycol, triethanolamine, 2-amino-1-butanol, 2-amino-2-methyl-1-propanol, 2-amino-2-ethyl-1-3-propanediol and morpholine.  Small amounts of wetting agents may be added, for instance, the diesters of sulphosuccinic acid.  Alkyl aryl sulphonates, fatty acid soaps of alkylolamines, fatty alcohol sulphates, sulphonated fatty alcohols, sulphates of mixed fatty acid glycerides, the alkylpyridinium and quaternary ammonium halides, the higher aliphatic amines, and the reaction products of higher fatty acids with polyalkylene polyamines.  Solvents for the sulphonamide may be present, such as an aqueous solution of an alkylolamine for 2-sulphonamide-pyrimidine or propylene glycol for sulphanilamide or 2-sulphanilamido-thiazole.  Aqueous solutions of urea or formamide may also be used and alcohol or acetone be added to assist solution or aid drying.  Other additions may be (1) a local antiseptic such as cetyl pyridinium chloride, an alkyl (C9-C14) dimethyl benzylammonium chloride, paratertiary octyl phenyldiethoxy - dimethylbenzyl ammonium chloride, or an alkyl phenol or resorcinol derivative; (2) a tissue growth promoter such as urea or allantoin; (3) a local an sthetic such as salicyl alcohol or gamma-(2-methyl-piperidine)-propyl benzoate hydrochloride; (4) a stabilizer such as thiourea, phenyl-thiourea, N-ethyl-thiourea, S-ethylpseudo thiourea, and N,N-diethylthiourea; (5) medicinal dyes such as acriflavine hydrochloride, 3,6 - diaminoacri - dinium monohydrogen sulphate, 2,8-diaminoacridinium monohydrogen sulphate, or triple dye; (6) substances to increase elastic properties such as castor oil, cod liver oil or their soaps; (7) film-forming agents such as bentonite, polyvinyl alcohol compounds, acrylates, hydrated alumina, casein or glue.ALSO:A surgical dressing, particularly for burns, comprises a preformed self-supporting film containing a water soluble cellulose derivative, a plasticiser, and a bacteriostatic sulphonamide, or a textile material on which the above substances have been deposited as by spraying or dipping.  The film itself may be formed by spraying or casting an aqueous solution or suspension of the film forming ingredients.  Typical solutions for spraying contain 3 per cent. of 2-sulphonilamidopyrimidine, 2 per cent. dimethyl cellulose, and either 2 per cent. sorbitol, one per cent. triethanolamine and 0.5 per cent. wetting agent or 4 per cent. propylene glycol and 0.5 per cent. wetting agent.  A third solution contains 3 per cent. each of methyl cellulose and the sulphonamide, 8 per cent. triethanolamine, 0.5 per cent. wetting agent, and 0.2 per cent. sorbitol.  Cellulose derivatives specified are methyl- or ethyl-cellulose ethers, hydroxyethylcellulose, hydroxyethylmethylcellulose ethyl cellulose acetate, methyl cellulose proprionate, hydroxyethyl cellulose butyrate, alkali metal salts of carboxymethyl cellulose or alkali metals salts of cellulose glycollic acid.  The term "bacteriostatic sulphonamide" is defined in the Specification and includes sulphonilamide, 2-sulphonilamidothiazole, 2-sulphanilamidopyrimidine, 2-sulphonilamidopyridine, disulphonilamide, and the various N1-sulphonilamides, such as N1-butyrlsulphonilamide and N1-dodecanoylsulphonilamide, as well as the water soluble (especially sodium) and water insoluble salts of the above compounds. Plasticizers include glycerin, sorbitol, mannitol, invert sugar solutions, propylene glycol, triethanolamine, 2-amino-1-butanol, 2-amino-2 methyl-1-propanol, 2-amino-2-ethyl-1-1-3-propanodiol and morpholine.  Small amounts of wetting agents may be added, for instance the diesters of sulphonsuccinic acid, alkylanyl-sulphonates, fatty acid soaps of alkylolamines, fatty alcohol sulphates, sulphonated fatty alcohols, sulphates of mixed fatty acid glycerides, the alkylpyridinium and quaternary ammoniumhalides, the higher aliphatic amines, and the reaction products of higher fatty acids with polyalkalene polyamines.  Solvents for the sulphonamide may be present such as an aqueous solution of an alkylolamine for 2-sulphonamidepyrimidine or propylene glycol for sulphonilamide or 2-sulphonilamidothiazole.  Aqueous solutions of urea or formamide may also be used and alcohol or acetone be added to assist solution or aid drying.  Other additions may be (1) a local antiseptic such as cetyl pyridinium chloride, an alkyl (C9-C14) dimethylbenzylammonium chloride, paratertiary octyl phenyldiethoxydimethylbenzylammonium chloride, or an alkyl phenol or resorcinol derivative; (2) a tissue growth promoter such as urea or allantoin; (3) a local anaesthetic such as salicyl alcohol or gamma (2-methyl-piperidine)-propyl benzoate hydrochloride: (4) a stabilizer such as thiourea, phenyl-thiourea, N-ethylthiourea, S-ethylpseudothiourea, and N, N-diethylthiourea; (5) medicinal dyes such as acriflavine hydrochloride, 3, 6, diaminoacridinium monohydrogen sulphate, 2, 8,-diaminoacridinium monohydrogen sulphate, or triple dye; (6) substances to increase elastic properties such as castor oil, cod liver oil or their soaps; (7) film forming agents such as bentonite, polyvinyl alcohol compounds, acrylates hydrated alumina, casein or glue. The dressings can be directly sterilized by dry heating or autoclaving.  The prior treatment of burns by an aqueous 2-sulphonilamidopyrimidine solution in triethanolamine is referred to.