Patent EA-001205-B1 (EA)
Title: New phenanthridines
Inventor: AMSCHLER HERMANN
IPC: C07D221/12
Filed: 1997-01-30
Abstract: 1. A compound of the formula I    in which R<1> is hydroxy, C1-C4alkoxy, C3-C7cycloalkoxy or C3-C7cycloalkylmethoxy or C1-C4alkoxy which is completely or partially substituted by fluorine, R<2> is hydroxy, C1-C4alkoxy, C3-C7cycloalkoxy or C3-C7cycloalkylmethoxy or C1-C4alkoxy which is completely or partially substituted by fluorine, or in which R<1> and R<2> together are a C1-C2alkylenedioxy group, R<3> is hydrogen or C1-C4alkyl, R<31> is hydrogen or C1-C4alkyl, or in which R<3> and R<31> together are a C1-C4alkylene group, R<4> is hydrogen or C1-C4alkyl, R<5> is hydrogen, R<51> is hydrogen, or in which R<5> and R<51> together are an additional bond, R<6> is a phenyl residue, which is substituted by R<7>, where R<7> is COOR<71> or CON(R<72>)R<73>, wherein R<71> is hydrogen, C1-C7alkyl, C3-C7cycloalkyl or C3-C7cycloalkylmethyl and R<72> and R<73> independently of one another are each hydrogen, C1-C7alkyl, C3-C7cycloalkyl or C3-C7cycloalkylmethyl, and the salts of this compound.  2. A compound of the formula I as claimed in claim 1, in which R<1> is C1-C4alkoxy, C3-C7cycloalkoxy or C3-C7cycloalkylmethoxy or C1-C2alkoxy which is completely or partially substituted by fluorine, R<2> is C1-C4alkoxy, C3-C7cycloalkoxy or C3-C7cycloalkylmethoxy or C1-C2alkoxy which is completely or partially substituted by fluorine, R<3> is hydrogen, R<31> is hydrogen, or in which R<3> and R<31> together are a C1-C2alkylene group, R<4> is hydrogen or C1-C4alkyl, R<5> is hydrogen, R<51> is hydrogen, or in which R<5> and R<51> together are an additional bond, R<6> is a phenyl residue, which is substituted by R<7>, where R<7> is COOR<71> or CON(R<72>)R<73>, where R<71> is hydrogen, C1-C7alkyl or C3-C7cycloalkylmethyl and  R<72> and R<73> independently of one another are each hydrogen or C1-C7alkyl, and the salts of these compounds.  3. A compound of the formula I as claimed in claim 1, in which  R<1> is C1-C4alkoxy, C3-C7cycloalkoxy or C1-C2alkoxy which is completely or partially substituted by fluorine,  R<2> is C1-C4alkoxy, C3-C7cycloalkoxy or C1-C2alkoxy which is completely or partially substituted by fluorine, R<3> is hydrogen, R<31> is hydrogen, or in which R<3> and R<31> together are a C1-C2alkylene group, R<4> is hydrogen or C1-C4alkyl, R<5> is hydrogen, R<51> is hydrogen, or in which  R<5> and R<51> together are an additional bond, R<6> is a phenyl residue which is substituted by R<7>, where R<7> is COOR<71> or CON(R<72>)R<73>, where  R<71> is hydrogen, C1-C7alkyl or C3-C7cycloalkylmethyl and R<72> and R<73> independently of one another are each hydrogen or C1-C4alkyl, and the salts of these compounds.  4. A compound of the formula I as claimed in claim 1, in which R<1> is methoxy, ethoxy or difluoromethoxy, R<2> is methoxy, ethoxy or difluoromethoxy, R<3> and R<31> are each hydrogen, R<4> is hydrogen, R<5> and R<51> are each hydrogen, R<6> is a phenyl residue which is substituted by R<7>, where R<7> is COOR<71> or CON(R<72>)R<73>, where  R<71> is hydrogen or C1-C4alkyl, R<72> is hydrogen and  R<73> is C1-C4alkyl, and the salts of these compounds.  5. A medicament comprising one or more compounds as claimed in claim 1 together with pharmaceutical auxiliaries and/or excipients.  6. The use of compounds as claimed in claim 1 for the production of medicaments for the treatment of respiratory diseases.