Patent GB-743600-A (GB)
Title: Vitamin-active powder and process for the manufacture thereof
IPC: A61K31/07
Filed: 1953-05-05
Abstract: Vitamin feed supplements are made by introducing droplets of an emulsion of a fat-soluble vitamin-active material in an aqueous solution containing a sugar or a sugar alcohol and gelatine or gum acacia into a mass of free-flowing starchy powder having a moisture content of below about 8 per cent, maintaining the vitamin-active particles in the powder separate from each other until their particulate form is established and then separating the particles from the powder.  The starchy collecting powder may be an unmodified or a chemically-modified starch, such as is prepared by reacting ungelatinized starch in an alkaline medium with a substituted succinic or glutaric acid anhydride and reacting the product with, e.g. aluminium sulphate, ferrous sulphate, barium chloride, strontium nitrate, copper sulphate, ceric sulphate, chromic chloride or zinc chloride, and drying. The powder may also contain additions such as talc, silicic acid, flours, hydrogenated fats and metal salts of higher fatty acids. Vitamin active materials specified include vitamin-bearing oils, pro-vitamins, pure vitamins and chemical derivatives such as Vitamin A acetate and palmitate.  Sugar and sugar alcohols specified include glucose, sucrose, partially - inverted sucrose, sorbitol and mannitol.  Antioxidants (tocopherols, butylated hydroxy-anisole), emulsifiers (lecithin), extenders and solubilizers (sesame oil, cottonseed oil) and other additives may be incorporated in the emulsions.  The emulsion droplets may be collected in a layer of the powder in such a way that they do not run together, or a spray of emulsion droplets may be introduced into a swirling cloud of powder in a rotating vessel.  The set-up droplets may be separated from the free powder and dried by conventional means.  In an example, an emulsion of Vitamin A acetate in an aqueous solution containing gelatine and sucrose is sprayed through a rotating spray head into a counter-rotating drum charged with a dried, free-flowing starch ester, the mixture screened to remove free powder and the set-up particles dried.ALSO:Droplets of an emulsion of a fat-soluble vitamin-active material in an aqueous solution containing a sugar or a sugar alcohol and gelatin or gum acacia are introduced into a mass of free-flowing starchy powder having a moisture content of below about 8 per cent, and the vitamin-active particles are maintained in the powder separate from each other until their particulate form is established and then the particles are separated from the powder. The starchy collecting powder may be an unmodified or a chemically-modified starch, such as is prepared by reacting ungelatinized starch in an alkaline medium with a substituted succinic or glutaric acid anhydride and reacting the product with e.g. aluminium sulphate, ferrous sulphate, barium chloride, strontium nitrate, copper sulphate, ceric sulphate, chromic chloride or zinc chloride, and drying.  The powder may also contain additions such as talc, silicic acid, flours, hydrogenated fats and metal salts of higher fatty acids.  Vitamin-active materials specified include vitamin-bearing oils, provitamins, pure vitamins and chemical derivatives such as vitamin A acetate and palmitate.  Sugar and sugar alcohols specified include glucose, sucrose, partially inverted sucrose, sorbitol and mannitol.  Antioxidants (tocopherols, butylated hydroxy-anisole), emulsifiers (lecithin), extenders and solubilizers (sesame oil, cottonseed oil) and other additives may be incorporated in the emulsions.  The emulsion droplets may be collected in a layer of the powder in such a way that they do not run together, or a spray of emulsion droplets may be introduced into a swirling cloud of powder in a rotating vessel.  The set-up droplets may be separated from the free powder and dried by conventional means.  In an example, an emulsion of vitamin A acetate in an aqueous solution containing gelatin and sucrose is sprayed through a rotating spray head into a counter rotating drum charged with a dried, free-flowing starch ester, the mixture screened to remove free powder and the set-up particles dried.