Patent SG-11201902944T-A (SG)
Title: Substituted pyridinone-containing tricyclic compounds, and methods using same
Inventor: GOTCHEV DIMITAR
IPC: C07D471/04
Filed: 2017-11-03
Abstract: ccO (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 May 2018 (11.05.2018) omits ioloOlign11011011101110#011 (10) International Publication Number WO 2018/085619 Al WIPO I PCT (51) International Patent Classification: A61K 31/495 (2006.01) CO7D 213/06 (2006.01) A61P 31/12 (2006.01) C07D 471/04 (2006.01) (21) International Application Number: PCT/US2017/059854 (22) International Filing Date: 03 November 2017 (03.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/418,478 07 November 2016 (07.11.2016) US 62/506,325 15 May 2017 (15.05.2017) US 62/512,990 31 May 2017 (31.05.2017) US (71) Applicants: ARBUTUS BIOPHARMA, INC. [US/US]; 701 Veterans Circle, Warminster, PA 18974-3531 (US). PROTIVA BIOTHERAPEUTICS, INC. [CA/CA]; 100 - 8900 Glenlyon Parkway, Burnaby, British Columbia V5J5J8 (CA). (72) Inventors: GOTCHEV, Dimitar, B.; 224 Diane Avenue, Hatboro, PA 19040 (US). DORSEY, Bruce, D.; 1213 Meetinghouse Road, Ambler, PA 19002 (US). KAKAR- LA, Ramesh; 5008 Grundy Way, Doylestown, PA 18902 (US). BI, Yingzhi; 5 Mershon Lane, Plainsboro, NJ 08536 (US). NGUYEN, Duyan; 106 Cypress Drive, Ambler, PA 19002 (US). CHEN, Shuai; 8480 Limekiln Pike, Apt. 924-3, Wyncote, PA 19095 (US). WOOD, Mark, Christo- pher; 27-100 Klahanie Drive, Port Moody, British Colum- bia V3H5K3 (CA). HOLLAND, Richard, James; 2828 East 16th Avenue, Vancouver, British Columbia V5M2M1 (CA). BAILEY, Lauren, Danielle; 50 South Penn Street - Apt. 201, Hatboro, PA 19040 (US). (74) Agent: SILVA, Domingos, J. et al.; Saul Ewing Arnstein & Lehr LLP, 1500 Market Street, 38th Floor, Philadelphia, PA 19102 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: - with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (54) Title: SUBSTITUTED PYRIDINONE-CONTAINING TRICYCLIC COMPOUNDS, AND METHODS USING SAME 0 (57) : The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising \" the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds 0 and compositions of the invention inhibit and/or reduce HBsAg secretion.