baber/WOPTO huggingface dataset:
Patent NZ-273838-A (NZ)
Title: Human receptor protein h4-1bb
Inventor: KWON BYOUNG S
IPC: C07K14/715
Filed: 1994-09-15
Abstract: The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from cDNA 4-1BB. A fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB was developed. It comprises the extracellular portion of the receptor protein H4-1BB and a detection protein (alkaline phosphatase) bound to the portion of the receptor protein H4-1BB. B-cells that have expressed a ligand to receptor protein H4-1BB can be treated with cells that have expressed receptor protein H4-1BB and B-cell proliferation may be induced. The use of H4-1BB to block H4-1BB ligand binding has practical application in the suppression of the immune system during organ transplantation. A monoclonal antibody against H4-1BB can be used to enhance T-cell proliferation by treating T-cells that have expressed receptor protein H4-1BB with the anti H4-1BB monoclonal antibody. Tumors transfected with H4-1BBL may be capable of delivering antigen-specific signals as well as the co-stimulatory signals and can be killed by human cytotoxic T lymphocytes.
Patent NZ-282459-A (NZ)
Title: Polymeric cation exchange membrane containing water insoluble salt of ag, w or mo and use in electrochemical cells
Inventor: COOLEY GRAHAM EDWARD
IPC: H01M50/497
Filed: 1995-03-24
Abstract: A modified polymeric cation exchange membrane for use in an electrochemical cell, the membrane having a salt selected from the group consisting of silver, tungsten, molybdenum and a mixture thereof deposited within the polymer matrix, the salt being insoluble in the electrolytes which, in use, contact either side of the membrane. The membranes are of particular use in electrochemical cells and combine a low electrolytic resistivity with a high permselectivity.
Patent NZ-292963-A (NZ)
Title: Compositions for regulating heme-oxygenase and nitric oxide in mammals
Inventor: WILLIS DEAN
IPC: A61K31/195
Filed: 1995-09-22
Abstract: Control of internal inflammation is achieved by control of the level and/or activity of the enzyme heme-oxygenase (HO). Alternative, or additional, control of heme-oxygenase activity is achieved by control of nitric oxide levels, elevated levels promoting inflammation.
Patent NZ-296003-A (NZ)
Title: A cathepsin o2 protease and antibodies thereto
Inventor: BROMME DIETER
IPC: C12N1/21
Filed: 1995-10-26
Abstract: The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.
Patent NZ-314680-A (NZ)
Title: Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide
Inventor: FISCHMAN ALAN JAY
IPC: A61K38/08
Filed: 1990-05-08
Abstract: Therapeutically conjugated chemotactic peptides of the general formula N-X-Y-Leu-Phe-Z-W for use in the manufacture of medicaments for the treatment of inflammation and infection wherein, X is a selected from the group of formyl, acetal, and t-boc, Y is Met of Nle, Z is a bond, or selected from the group of Gly-Gly-Gly and Nle-Tyr and W is a labeling substituent selected from the group consisting of Lys, Lys(NH2), Dlys(NH2) and Pu, A detectable label is bound indirectly via DTPA or EDTA to the C-terminal amino acid residue of the chemotactic peptide. The peptide accumulates at sites of infection or inflammation and does not accumulate at a site were there is no infection.
Patent NZ-335482-A (NZ)
Title: Process for the formation of a fuel mixture and for its ignition in a pre-chamber that is open toward the cylinders
Inventor: RIGAZZI PIER ANDREA
IPC: F02P13/00
Filed: 1997-11-03
Abstract: Process for ensuring the mixing of a preset quantity of liquid or gaseous fuel with the air that is contained in a pre-chamber with one end that is open toward cylinder or cylinders in a reciprocating internal combustion engine in which no fuel is injected into the cylinder or cylinders, as well as the ignition of the mixture that is thus obtained, with the fuel being injected axially from a closed end of the pre-chamber by means of an injector that is actuated by a surplus of pressure (Dp) compared to that which is present in the pre-chamber itself, whereby the injection of fuel is accomplished during the compression half-cycle of the internal-combustion engine, and the injector and the surplus (Dp) that ensures its delivery are such as to ensure that the fuel jet that is injected is completely evaporated and/or mixed with the air that is contained in the pre-chamber at the moment when the jet reaches the open end of the pre-chamber itself and that, during its translation movement, is mixed with the above-mentioned air in accordance with a richness value of the mixture which can be represented with a preset curve that rises from the injection point towards the centre of the open end of the pre-chamber, wherein the average richness value of the mixture in a defined volume of air located near the closed end of the pre-chamber is substantially zero, pre-chamber being sized such that, during the interval of time in which combustion takes place therein, the volume that contains air expands under the action of the withdrawal motion of the piston or pistons, ultimately occupying its entire volume and keeping the position of the combustion front essentially close to the opening of the pre-chamber for the entire duration of the combustion.
Patent NZ-500778-A (NZ)
Title: Data tracking system for currency operated gaming machines
Inventor: WALSH MICHAEL
IPC: G07F9/08
Filed: 1997-05-09
Abstract: A currency operated gaming machine includes a currency validator 16 attached to lockable removable cassette (LRC) 20. The LRC has non-volatile memory to hold data transferred to it by the validator 16 and by identification adaptor IDA.  The IDA reads and analyses information regarding currency value, unequal amounts, cash receipts and efficiency of the machine.  The IDA has a unique identification number.  Periodically the LRC is removed from the machine and the memory is interrogated by a soft count supervisor which may consist of a PC or laptop computer running spreadsheet software.
Patent NZ-501138-A (NZ)
Title: Hypersensitive response elicitor protein or polypeptide fragments from Erwinia
Inventor: LABY RONALD J
IPC: H04N5/44
Filed: 1998-05-28
Abstract: An isolated fragments of an Erwinia hypersensitive response elicitor protein or polypeptide which fragments elicit a hypersensitive response in plants. Also disclosed are isolated DNA molecules which encode the Erwinia hypersensitive response eliciting fragment. Isolated fragments of hypersensitive response elicitor proteins or polypeptides, which elicit a hypersensitive response, and the isolated DNA molecules that encode them can be used to impart disease resistance to plants, to enhance plant growth, and/or to control insects on plants. This can be achieved by applying the hypersensitive response eliciting fragments in a non-infectious form to plants or plant seeds under conditions effective to impart disease resistance, to enhance plant growth, and/or to control insects on plants or plants grown from the plant seeds. Alternatively, transgenic plants or plant seeds transformed with a DNA molecule encoding a hypersensitive response eliciting fragment can be provided and the transgenic plants or plants resulting from the transgenic plant seeds are grown under conditions effective to impart disease resistance, to enhance plant growth, and/or to control insects on plants or plants grown from the plant seeds.
Patent NZ-501777-A (NZ)
Title: Polypeptides encoding DCMP1 and DCMP2, including a fusion polypeptide of both DCMP1 and DCMP2 and antibodies thereof
Inventor: VALLADEAU JENNY
IPC: C07K19/00
Filed: 1998-07-08
Abstract: A substantially pure or recombinant dendritic cell membrane proteins (DCMP) having similarity with lectins and asialoghycoprotein receptors with at least 10 contiguous amino acid residues as shown in Seq ID 2 or Seq ID 8 is described. Methods of producing recombinant polypeptides and diagnostic methods thereof are described. The polypeptides are useful as markers, and may function in controlling development, differentiation and physiology of the mammalian immune system. Seq ID 2 MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPL KSNTGFPKLLCASLLIFFLLLAISFFIAFVIFFQKYSQ LLEKKTTKELVHTTLECVKKNMPVEETAWS Seq ID 8 CTKSVSPMEDKVWSCCPKDWRLFGSHCYLVPTVSS SASWNKSEENCSRMGAHLVVIQSQEEQDFITGILDT HAAYFIGLWDTGHRQWQWVDQTPYEESITFWHNG EPSSGNEKCATIIYRWKTGWGWNDISCSLKQKSVC QMKKINL
Patent NZ-504460-A (NZ)
Title: Sustained release formulations containing venlafaxine
Inventor: CLARK JOHN CLIFTON
IPC: A61K31/137
Filed: 1998-11-03
Abstract: Described is a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant.  The formulation provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets.  In its primary aspect, an improved core of the extended release spheroids is provided.  This core is comprised of venlafaxine hydrochloride and microcrystalline cellulose, that is, without the addition of hydroxypropylmethylcellulose.
Patent NZ-508358-A (NZ)
Title: A method for checking a DNA fragment (target nucleic acid) for the presence or absence of a mutation
Inventor: MCCARTHY THOMAS VALENTINE
IPC: C12Q1/6827
Filed: 1998-04-22
Abstract: A method for characterising nucleic acid molecules comprises the steps of: I) introducing a modified base, which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base by means of said DNA glycosylase so as to generate an abasic site; iii) cleaving the DNA at the abasic site so as to generate an upstream DNA fragment that can be extended; and iv) incubating the extendible upstream fragment in the presence of an enzyme, for example a polymerase or a ligase, allowing for extension thereof and a template nucleic acid and analysing the resultant fragment(s). The invention provides a versatile and simple method using the above-mentioned extendible upstream DNA fragments which allows characterisation of nucleic acids and which has advantages over existing methods.  One of the most important uses (but not the only use) of the method according to the invention is to scan or check a fragment of DNA (target nucleic acid) for the presence or absence of a mutation.
Patent NZ-512778-A (NZ)
Title: A toilet with water supplied directly from mains supply (no cistern), having a venturi effect inducing water inlet at the base/rear of the bowl and also rim mounted jets orientated to provide a clockwise 'rinsing' of the bowl.
IPC: E03D3/00
Filed: 2002-01-05
Abstract: The present invention relates to an improved toilet and flushing system, wherein the system includes a toilet bowl; a pressured water supply; at least one flow regulator and at least one water outlet; characterized in that the system includes at least one control device configured to operate said flow regulator(s) to control the flow of the pressured water supply, and wherein the outlet(s) are configured to deliver water from the pressured water supply, so that water from the pressured water supply which creates a venturi effect to evacuate waste and water from the bowl and travels along wall(s) of the toilet bowl to wash and refill the toilet.
Patent NZ-513376-A (NZ)
Title: Cloches suitable for row or raised bed plants characterised by a two piece arcuated screen drawn together with drawstrings
Inventor: TEMPLE ANDREW B
IPC: A01G13/02
Filed: 2001-08-06
Abstract: A retractable, plastic enclosure (30) for row crops, ideally tomatoes, comprises a pair of plastic walls (33,34) bordering the seedbed (22) that are supported by spaced-apart ribs (40,42). Row crops between the closed walls are shielded from extreme conditions including frost, heavy rain, freeze, hail, and winds. Folding a sheet of plastic forms the multi-ply, plastic walls. Arcuate ribs (40,42) flexibly secure the walls in symmetric, spaced apart, parallel rows adjoining crops on either side of the raised seedbed. The walls may be yieldably drawn together or forced apart by drawstrings (82,80). The ribs are formed from multiple separate strips (50,52) that are stapled together and sandwich at least one wall layer. The drawstrings are routed between spaced-apart rib guides in zigzag fashion. Tensioning of the lower drawstrings closes the walls, sheltering the young row crops. The upper drawstring opens the walls.
Patent NZ-516630-A (NZ)
Title: Method for storing and improving the survival rate of conifer somatic embryo germinants on a germination medium
Inventor: WELTY DOROTHY ELAINE
IPC: A01H7/00
Filed: 1998-10-26
Abstract: A method of storing conifer somatic embryo germinants on germination medium for delayed transplanting into growing medium.  The method comprises placing the germinants in a cold environment in the range of 1o-5oC for a period of up to two weeks while they are still on the germination medium.  The germinants are then removed from the cold environment and transplanted into a potting medium for further growth.
Patent NZ-524444-A (NZ)
Title: Bicyclic heteroaromatic compounds
Inventor: TIMMERS CORNELIS MARIUS
IPC: C07D239/78
Filed: 2001-09-17
Abstract: A bicyclic heteroaromatic compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6- 14C)aryl or (4-13C)heteroaryl; all optionally substituted with one or more substituents; R2 is (1-4C)alkyl, (2- 4C)alkenyl, (2-4C)alkynyl, (6-14C)aryl or (4- 13C)heteroaryl; R3 is (1-8C)alkyl, (3-8C)cycloalkyl, (2- 7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl; Y is CH or N; Z is NH2 or OH; A is S, N(H), N(R), O or a bond and B is N(H), O or a bond; X1-X2 is C=C, C(O)-NH, NH-C(O), C(O)-O, O-C(O), C=N, N=C or S or O. The compounds of the invention can be used in fertility regulation therapies.
Patent NZ-527297-A (NZ)
Title: Immunosuppression by blocking T cell co-stimulation signal 2 (B7/CD28 interaction)
Inventor: LECHLER ROBERT IAN
IPC: A61K39/395
Filed: 1999-04-30
Abstract: Methods and biological reagents for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 in order to prevent the activation of xenoreactive T-cells in the recipient. Conventional immunosuppressive techniques may be used alongside those disclosed. The reagent comprises a membrane associated protein which can bind to CTLA-4 to antagonise the co-stimulatory signal 2 provided by the interaction between B7 and CD28, provided that the protein is not B7. Preferably the reagent is a chimeric membrane-associated protein which can bind top CTLA-4, or a membrane comprising a single chain antibody. The membrane associated protein may be present on a cell, preferably a cell expressing MHC on its surface.
Patent NZ-531598-A (NZ)
Title: A pharmaceutical composition comprising a sulphonated meso-tetraphenyl chlorin as a photosensistizing agent for use in photodynamic therapy
Inventor: RIMINGTON CLAUDE
IPC: A61K41/00
Filed: 2002-08-30
Abstract: Photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin are described, particularly a disulphonated meso-tetraphenylporphyrin such as TPPS2a. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is -SO3H; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, isomers and isomer mixtures thereof. The compounds described and their pharmaceutically acceptable salts have particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.
Patent NZ-535760-A (NZ)
Title: Method of operation and system for discrimination between multiple surface acoustic wave identification tags
Inventor: HARTMANN CLINTON S
IPC: G01S13/75
Filed: 2003-03-19
Abstract: A system (100) for discriminating between coded responses from multiple surface acoustic wave (SAW) identification tags (120) is disclosed. The system comprises a SAW tag reader (130) subsystem that detects coded responses (110) from the tags to an interrogation pulse; and a coded response analyzing subsystem (140), coupled to the SAW tag reader subsystem that employs signal processing techniques to develop a synthetic coded response from the coded responses and generates possibilities from the synthetic coded responses. The system can further comprise an inertial guidance system selected from an inertial guided antenna system, an inertial guided reader system and an inertial guided platform system. The system can further comprise a sensor subsystem that detects other physical properties of the tags. The coded response analyzing subsystem employs the signal processing techniques and the physical properties to generate the possibilities. A system for verifying a coded response by a SAW identification tag (120) to an interrogation pulse (110), comprises a pulsetrain generating subsystem (150) that generates a pulsetrain (155) that is a time-reversed form of the coded response and a SAW tag reader subsystem (130), coupled to the pulsetrain generating subsystem, that receives a pronounced pulse from the tag that approximates the interrogation pulse.
Patent NZ-535911-A (NZ)
Title: Dipyridodiazepinones as HIV reverse transcriptase inhibitors
Inventor: O'MEARA JEFFREY
IPC: A61K31/55
Filed: 2003-03-24
Abstract: Disclosed is a compound of formula I wherein R2 is H, halogen, alkyl, O-alkyl, NH-alkyl or N(alkyl)2; R4 is H or CH3; R5 is H or CH3, provided that R4 and R5 are not both the same; R12 is H, halogen, alkyl, CF3, or NO2; R13 is H, alkyl, halogen, OH, or NH2, with the proviso that R12 and R13 are not both H; and R14 is COOR14a, alkenyl-COOR14a or alkyl-COOR14a wherein R14a is H or alkyl. Compounds of the type disclosed are inhibitors of reverse transcriptase useful in the treatment and prevention of HIV infection.
Patent NZ-536202-A (NZ)
Title: Tri-substituted heteroaryls and methods of making and using the same
Inventor: LEE WEN-CHERNG
IPC: A61P11/00
Filed: 2003-04-04
Abstract: Disclosed is a compound of formula (I) or an N-oxide or pharmaceutical acceptable salt thereof wherein R1 is aryl, heteroaryl, aralkyl or heteroaralkyl; X is piperidinyl, piperazinyl, pyrrolidinyl, tetrahydrofuran, cyclohexyl, cyclopentyl, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.1]octane, 2-oxa-bicyclo[2.2.2]octane, 2-aza- bicyclo[2.2.2]octane, 3-aza- bicyclo[3.2.1]octane or 1-aza-bicyclo[2.2.2]octane; Each of A1 and A2 are independently O, S, N or NRb provided that at least one of A1 and A2 is N; and the remainder of the substituents are as described in the specification. The compounds described are antagonists of the TGF beta type I receptors Alk5 and Alk4 useful in the treatment of disorder related to the TGF beta signalling pathway.
Patent NZ-539153-A (NZ)
Title: Polysaccharide vaccine for staphylococcal infections
Inventor: PIER GERALD B
IPC: A61K39/085
Filed: 2003-11-12
Abstract: Disclosed is a composition comprising an isolated polysaccharide comprising a beta-1,6-glucosamine polymer, having a length of at least four monomeric units, wherein less than 40% of glucosamine groups are substituted with acetate, and wherein the composition is sterile. The isolated polysaccharide is used for the manufacture of a composition for treating or preventing a Staphylococcus infection.
Patent NZ-539937-A (NZ)
Title: Refrigeration apparatus that efficiently evaporates defrost water
Inventor: SALT RICHARD GEORGE PHILLIP
Filed: 2005-05-10
Abstract: Refrigeration apparatus that disposes of water produced during defrosting in an efficient and hygienic matter is disclosed. The apparatus includes an evaporator 24, a compressor 25, and a condenser 23, connected by pipework 30 in a known manner, and a fan and tray 28 arranged to collect water during a defrost cycle. The compressor, condenser, fan, and tray are contained in a housing that is substantially closed except for air vents, and at least part of the pipework between the compressor and condenser is located within the tray. The condenser is also located in the tray. The fan, housing, and tray are arranged so that the fan moves air through the housing and substantially all of this air is directed over the tray surface. The pipework and condenser heat the water in the tray and the combination of heating and rapid warm air flow across the tray aids evaporation of the defrost water in the tray. This arrangement of components is particularly applicable to apparatus that produces a significant amount of water during defrosting, such as open deck refrigeration cabinets.
Patent NZ-540958-A (NZ)
Title: Veterinary formulation for injectable administration of selenomethionine for production of selenium-rich foods
Inventor: KNOWLES SCOTT OLIVER
IPC: A23L13/00
Filed: 2005-06-27
Abstract: Disclosed is a veterinary formulation for injectable administration, which includes: selenomethionine; at least one oil-based vehicle; and optionally a suspending agent such as beewax; wherein upon administration the formulation forms a depot. The formulation is suitable for administration to animals for increasing the blood concentration of selenium, thereby increasing the selenium content in milk and/or meat from the animals for the subsequent nutritional benefits in humans.
Patent NZ-541973-A (NZ)
Title: Immunomodulating heterocyclic compounds
Inventor: MATHEWS IAN RICHARD
IPC: C07D487/04
Filed: 2004-03-10
Abstract: Disclosed is a compound of formula (I) or a pharmaceutically of veterinarily acceptable salt, hydrate or solvate thereof: wherein X represents a bond or a divalent radical of formula -(Z)n-(Alk)- or -(Alk)-(Z)n- wherein Z represents -O-, -S- or -NH-, Alk is defined in relation to R6, n is 0 or 1 and the rest of the substituents are disclosed within the specification. Disclosed is the use of the above compound in the manufacture of a medicament for the treatment of conditions which benefit from immunomodulation.
Patent NZ-543159-A (NZ)
Title: Ultrasonic cleaning of the inside surface of wine barrels
Inventor: LEE SUSAN
IPC: B08B3/12
Filed: 2004-07-16
Abstract: Methods and apparatus are disclosed for ultrasonic cleaning of the inside of a container, in particular a wine barrel (22). The container must have a bung hole (20) and is at least partially filled with a liquid. An ultrasonic processor has a shaft (12) that is inserted into the container through the bung hole and is immersed in the liquid. An ultrasonic generator (18) produces a signal and a transducer is associated with the shaft. The shaft induces ultrasonic waves throughout the liquid to clean the interior surface of the container that is exposed to the liquid.
Patent NZ-546258-A (NZ)
Title: New formulation for soft gelatin capsules containing Vitamin A analogues
Inventor: DITZINGER GUNTER
IPC: A61K36/31
Filed: 2004-10-28
Abstract: Disclosed is a pharmaceutical formulation for retinoids comprising a soft gelatin capsule filled with a fill mass comprising a retinoid as an active ingredient, a natural vegetable oil, a partially hydrogenated natural vegetable oil and medium chain triglycerides, and wherein the fill mass in addition comprises a natural wax.
Patent NZ-550860-A (NZ)
Title: Methods for therapy and diagnosis of ovarian cancer
Inventor: MITCHAM JENNIFER L
IPC: A61K38/00
Filed: 1999-12-17
Abstract: Provided is an isolated polypeptide comprising at least an immunogenic portion of an ovarian carcinoma protein, or a functional variant thereof that differs in one or more substitutions, deletions, additions and/or insertions such that the ability of the variant to react with antigen-specific antisera is not substantially diminished wherein the ovarian carcinoma protein comprises a specified amino acid sequence. Further provided are vaccines comprising said polypeptide, and uses of the polypeptide for manufacturing pharmaceuticals to treat ovarian carcinoma and for determining presence or absence of cancer. Also provided are antibodies to said polypeptide.