baber/WOPTO huggingface dataset:
Patent EP-3570895-A1 (EP)
Inventor: DALKARA DENIZ
IPC: A61K48/00
Filed: 2018-01-16
Abstract: Intraocular injection of adeno-associated viral (AAV) vectors has been an evident route for delivering gene drugs into the retina. Currently, the vectors need to be injected into the subretinal space in order to provide gene delivery to cones. In this approach, gene delivery is limited to cells that contact the local "bleb" of injected fluid. Furthermore, retinal detachment that occurs during subretinal injections is a concern in eyes with retinal degeneration. Here, the inventors establish several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea with supporting studies in mouse models, human induced pluripotent stem cell-derived organoids, post-mortem human retinal explants and living macaques. They show that an engineered AAV2 variant provides gene delivery to foveal cones with a well-tolerated dose administered intravitreally. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Accordingly, the present invention relates to method of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising intravitreal delivery of a therapeutically effective amount of a recombinant AAV2-derived vector comprising a VP1 capsid protein as set forth in SEQ ID NO: 1 and the polynucleotide of interest under the control of the PR1.7 promoter as set forth in SEQ ID NO:2.
Patent EP-3585634-A1 (EP)
Inventor: EGGEBRECHT DETLEV
IPC: B60T17/00
Filed: 2018-01-24
Abstract: Druckluftversorgungsanlage (10) zum Betreiben einer Pneumatikanlage (90), aufweisend: eine Druckluftzuführung (1); einen Druckluftanschluss (2) zur Pneumatikanlage (90); einen Entlüftungsanschluss (3) zur Umgebung; eine pneumatische Hauptleitung (60) zwischen der Druckluftzuführung (1) und dem Druckluftanschluss (2), die einen Lufttrockner (61) aufweist; eine Entlüftungsleitung (70) zwischen der Druckluftzuführung (1) und dem Entlüftungsanschluss (3); eine Ventilanordnung (80) mit einem Steuerventil (81) zur Steuerung eines Entlüftungsventils (71), wobei das Steuerventil (81) mit einem SteuerventilAnschluss (X2, Y2) in einer, an einem Drucksteueranschluss (71S) des Entlüftungsventils (71) angeschlossenen, pneumatischen Steuerleitung (110), und das Entlüftungsventil (71) mit einem Entlüftungsventilanschluss (X1, Y1) in der Entlüftungsleitung (70) angeschlossen ist, wobei dem Steuerventil (81) ein Steuerventil-Entlüftungs-Anschluss (Z2) zugeordnet ist, der über das Entlüftungsventil (71) schaltbar mit dem Entlüftungsanschluss (3) oder einem Umgebungsanschluss (3') verbindbar und über das Entlüftungsventil (71) schaltbar von dem Entlüftungsanschluss (3) oder dem Umgebungsanschluss (3') trennbar ist.
Patent EP-3577956-A1 (EP)
Inventor: CHEN WANSHI
IPC: H04L5/00
Filed: 2018-02-05
Abstract: Described techniques provide for low latency transmission time interval (TTI) transmissions that may have reduced likelihood of experiencing interference from one or more neighboring transmitters. A base station may configure two or more sets of resources for two or more sets of wireless transmissions, in which low latency transmissions may be transmitted in a set of wireless transmissions using all or a portion of one of the sets of resources. The set of resources available for the low latency transmissions may be associated with a set of power parameters that provide reduced transmission powers relative to one or more of the other sets of resources. The two or more sets of resources may include one or more sub-bands of available frequency resources, one or more subsets of time resources, or combinations thereof. In some cases, neighboring base stations may coordinate sets of resources that have reduced power parameters.
Patent EP-3652806-A1 (EP)
Inventor: WOLF KEVIN MATTHEW
IPC: H01Q1/38
Filed: 2018-02-06
Abstract: A hybrid patch antenna assembly is provided including an antenna element board having first and second layers separated by a dielectric and a radio board coupled to the antenna element board by at least two legs of a ladder line and separated from the antenna element board by a predetermined distance such that the antenna element board is suspended above the radio board.
Patent EP-3582691-A1 (EP)
Inventor: RAMACHANDRAN GANESAN
IPC: A61B8/12
Filed: 2018-02-12
Abstract: Disclosed is a computer-implemented method (200) for determining an ovarian follicle count and size (diameter) from a pair of 2-D transvaginal ultrasound scans. The method comprises receiving (210) the pair of 2-D (two-dimensional) transvaginal ultrasound scans (15, 15'), each scan comprising a plurality of 2-D ultrasound images (150, 150') captured along a translation direction (155, 155') of an ultrasound probe (14) used to capture said scan, the respective translation directions being at least approximately orthogonal, and for each of said scans, the method further comprising detecting candidate follicles (152) in the plurality of 2-D ultrasound images of the at least one 2-D transvaginal ultrasound scan; and segmenting (240) the detected candidate follicles to determine (248) an average diameter for each candidate follicle; selecting (270) the 2-D transvaginal ultrasound scan including the candidate follicle having the largest average diameter; and presenting (280) the determined average diameters and the segmentations of the detected candidate follicles of the selected 2-D transvaginal ultrasound scan. A computer program product, ultrasound image processing device and ultrasound imaging system adapted to implement this method are also disclosed.
Patent EP-3646414-A1 (EP)
Title: Method and device for producing a wire connection, and component arrangement with wire connection
Inventor: KOLBASOW ANDREJ
IPC: H01R4/02
Filed: 2018-03-15
Abstract: The invention relates to a method and a device for producing a wire connection between a first contact surface and at least one further contact surface (42), in which a contact end of a wire is positioned by means of a wire guidance tool in a contact position opposite the first contact surface and subsequently a mechanical, electrically conducting link is formed between the first contact surface and the contact end by means of a first soldered material joint (38), and subsequently the wire guidance tool is moved, forming a section of wire to the further contact surface (42), and a further mechanical, electrically conducting link is formed between the end of the wire section (45) and the further contact surface (42) by means of a further soldered material joint (48). The invention further relates to a component arrangement having a plurality of electronic components, particularly in the form of chips.
Patent EP-3596405-A1 (EP)
Title: Warmwasser-speicher und warmwasser-kleinspeicher
Inventor: HOFFMANN FRED
IPC: F24H1/18
Filed: 2018-03-13
Abstract: Die vorliegende Erfindung betrifft einen Warmwasser-Speicher (100), weicher eine elektronische Regeleinheit (130) aufweist, mittels welcher verschiedene Betriebsarten des Speichers eingestellt werden können. Diese Betriebsarten können eine Normalbetriebsart (bei einer Solltemperatur zwischen 30°C und 100°C), eine Frostschutzbetriebsart (bei einer Temperatur < 10°C und > 1°C), eine Zeitschaltuhrbetriebsart (bei der mit einer einstellbaren Zeitschaltuhr Zeiten unterschiedlicher Solltemperaturen einstellbar sind), eine ECO-Betriebsart (bei der eine elektronische Temperaturbegrenzung zwischen 30°C und 55°C eingesteht wird), eine Hygienebetriebsart (bei der eine periodische Temperaturerhöhung von > 55°C eingestellt wird) und/oder eine Trockengangerkennungs- Betriebsart (bei der eine Temperaturdifferenz zwischen einer ersten Temperatur und einer zweiten Temperatur nach einem Aufheizen des Warmwasserspeichers ermittelt wird) darstellen.
Patent EP-3621978-A1 (EP)
Inventor: HAUSER CHARLOTTE A E
IPC: C07K5/11
Filed: 2018-03-29
Abstract: The present invention relates to peptides capable of forming a gel and to their use in tissue engineering and bioprinting. The present invention furthermore relates to a gel comprising a peptide in accordance with the present invention, to a method of preparing such gel and to the use of such gel. In one embodiment, such gel is a hydrogel. The present invention furthermore relates to a wound dressing or wound healing agent comprising a gel according to the present invention and to a surgical implant or stent comprising a peptide scaffold formed by a gel according to the present invention. Moreover, the present invention also relates to a pharmaceutical and/or cosmetic composition, to a biomedical device or an electronic device comprising the peptide according to the present invention.
Patent EP-3609990-A1 (EP)
Title: Polymere als additive für kraft und schmierstoffe
Inventor: FLORES-FIGUEROA AARON
IPC: C10L1/196
Filed: 2018-04-03
Abstract: Verwendung von Copolymeren, erhältlich durch in einem ersten Reaktionsschritt (I) Copolymerisation von (A) mindestens einer ethylenisch ungesättigten Mono- oder Dicarbonsäure oder deren Derivate, bevorzugt einer Dicarbonsäure, (B) mindestens einem α-Olefin mit von mindestens 12 bis zu einschließlich 30 Kohlenstoffatomen, (C) optional mindestens einem weiteren, mindestens 4 Kohlenstoffatome aufweisenden, aliphatischen oder cycloaliphatischen Olefin, das ein anderes als (B) ist und (D) optional eines oder mehrerer weiterer copolymerisierbarer Monomere, die verschieden von den Monomeren (A), (B) und (C) sind, ausgewählt aus der Gruppe bestehend aus (Da) Vinylestern, (Db) Vinylethern, (De) (Meth)acrylsäureestern von Alkoholen, die mindestens 5 Kohlenstoffatome aufweisen, (Dd) Allylalkoholen oder deren Ether, (De) N-Vinylverbindungen, ausgewählt aus der Gruppe bestehend aus Vinylverbindungen von mindestens ein Stickstoffatom enthaltenden Heterocyclen, N-Vinylamide oder N-Vinyllactame, (Df) ethylenisch ungesättigte Aromaten (Dg) α,β-ethylenisch ungesättigte Nitrilen, (Dh) (Meth)acrylsäureamiden und (Di) Allylaminen, gefolgt von in einem zweiten Reaktionsschritt (II) teilweiser oder vollständiger Umsetzung von im aus (I) erhaltenen Copolymer enthaltenen Anhydrid- oder Carbonsäurefunktionalitäten mit mindestens einer Verbindung (E), die mindestens eine Alkoholgruppe oder Aminogruppe sowie mindestens eine Carbonsäuregruppe oder Carbonsäureestergruppe aufweist, und in einem dritten Reaktionsschritt (III) Hydrolyse der im aus (II) erhaltenen Copolymer enthaltenen Anhydridfunktionalitäten und/oder teilweise oder vollständige Verseifung von im aus (II) erhaltenen Copolymer enthaltenen Carbonsäureesterfunktionalitäten als Kraftstoff- oder Schmierstoffadditiv, insbesondere Dieselkraftstoffadditiv.
Patent EP-3615431-A1 (EP)
Inventor: BOURGEOIS MARC RICHARD
IPC: B65D75/58
Filed: 2018-04-16
Abstract: Methods of opening and adding expansion materials to containers made from flexible materials. The methods involve forming a partially completed container blank that may have four layers of flexible materials. The partially completed container blank may be opened by separating a portion of the first layer from a portion of the second layer by bending portions of the second, third, and fourth layers toward a first direction; and dosing the partially completed container blank, by adding an expansion material out of a dispenser and into a space disposed between a portion of the first layer and a portion of the second layer.
Patent EP-3599840-A1 (EP)
Inventor: CHAUMOT ARNAUD
IPC: A01K1/03
Filed: 2018-03-29
Abstract: L'invention concerne une cage (1) pour étude comportementale d'organismes vivants, notamment pour toximètre, comprenant au moins un compartiment (2) destiné à recevoir un organisme vivant, la cage (1) étant transparente au moins sur une face d'observation (4) afin de permettre l'observation des êtres vivants à partir d'un point d'observation (10) situé à distance de la face d'observation (4), le compartiment (2) étant délimité par des séparations (3), caractérisée en ce que la paroi (31a) d'une séparation (3a) est inclinée par rapport à la paroi (32b) d'une autre séparation (3b) de sorte à ce que les parois (31a, 32b) des séparations (3a, 3b) d'un compartiment (2) se rapprochent en direction de la face d'observation (4),lesdites séparations (3a, 3b) étant alignées selon des lignes de fuite concurrentes au point d'observation (10).
Patent EP-3634348-A1 (EP)
Inventor: SMET STEVEN
IPC: A61F13/511
Filed: 2018-05-14
Abstract: An absorbent article comprising a liquid pervious topsheet, a liquid impervious backsheet, and an absorbent core comprising an absorbent material between a top core wrap sheet and a back core wrap sheet, said absorbent core being positioned in between said topsheet and said backsheet; said absorbent core having a first and second longitudinal edge (131, 132) and a front and rear transverse edge (133, 134), wherein the absorbent core is provided with a plurality of attachment zones where the top core wrap sheet is attached to the back core wrap sheet, wherein the plurality of attachment zones comprises: at least a first and a second elongate attachment zone, said first and second elongate attachment zone extending next to each other from a crotch region in the direction of the front and/or rear transverse edge; at least one connecting attachment zone connecting said first attachment zone with said second attachment zone.
Patent EP-3624807-A1 (EP)
Inventor: BOHBOT SERGE
IPC: A61P17/02
Filed: 2018-05-16
Abstract: The subject of the present invention is a synthetic polysulfated oligosaccharide having 1 to 4 monosaccharide units, salts thereof, and complexes thereof, for use thereof for treating diabetic foot ulcer in arteriopathic patients.
Patent EP-3614881-A1 (EP)
Inventor: VAN DIJK JOPPE GIDEON
IPC: A46B9/04
Filed: 2018-04-26
Abstract: A mouthpiece for a dental cleaning device comprises a supporting structure configured to encompass a plurality of teeth of a dental arch. The supporting structure has an inner surface facing a tooth surface. At least one brushing chamber is provided at the inner surface side. The brushing chamber comprises a flexible wall part being deformable by pressurizing or depressurizing the brushing chamber. Bristles extend externally from the flexible wall part. In a method of brushing teeth, a plurality of teeth is encompassed by the mouthpiece, and the at least one brushing chamber is alternatingly pressurized and depressurized.
Patent EP-3620031-A1 (EP)
Inventor: GULATI KAPIL
IPC: H04W88/04
Filed: 2018-04-24
Abstract: The present aspects relate to device-to-device (D2D) relaying in a wireless communication system. In an aspect, a relay user equipment (UE) may receive, on a downlink channel from a network entity, at least one indication including resource allocation information for at least one of the relay UE or a remote UE. The relay UE may further transmit, on a sidelink channel to the remote UE, the resource allocation information of the remote UE. In another aspect, a remote UE may receive, on at least one sidelink channel, resource allocation information from a relay UE, the resource allocation information indicating one or more resources allocated for sidelink communication for the remote UE. The remote UE may further transmit, on one or more sidelink channels, data to the relay UE in accordance with the one or more resources allocated for sidelink communication.
Patent EP-3628045-A1 (EP)
Inventor: RICHARDS GARETH
IPC: C07D471/20
Filed: 2018-05-16
Abstract: L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci : (I) dans laquelle R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 et n sont tels que définis dans la description. Les composés sont des inhibiteurs du sous-type 2 du récepteur d'adrénomédulline (AM2). L'invention concerne également des composés destinés à être utilisés dans le traitement de maladies modulées par AM2, y compris des maladies prolifératives telles que le cancer; des compositions pharmaceutiques comprenant les composés; des procédés de préparation des composés; et des intermédiaires utiles dans la préparation des composés.
Patent EP-3790512-A1 (EP)
Title: Apparatus for transforming teeth into bone graft material
Inventor: MINETTI ELIO
IPC: A61F2/46
Filed: 2018-05-08
Abstract: There is provided an apparatus (1) for transforming teeth into bone material, which is suitable to treat said teeth by immersion in liquids and comprises a reactor device (2) including contact means (20), a reaction chamber (21) and an ejection chamber (22), a cartridge (3) including a plurality of containers (30) for the processing and washing liquids, separated liquid-tight from each other, a fragmentation device (4) suitable to fragment teeth, a guide (12) suitable to detachably connect the cartridge (3) and the fragmentation device (4) to the apparatus (1), and a movement device (11) suitable to detachably connect at least partially the reactor device (2) and allow it to sequentially withdraw the teeth from the fragmentation device (4) and the liquids from the cartridge (3).
Patent EP-3638097-A1 (EP)
Inventor: YAO XINCHENG
IPC: A61B3/14
Filed: 2018-06-13
Abstract: A non-mydriatic, non-contact ultra-widefield fundus (u-WF) photographic imaging system and method are provided for performing u-WF photographic imaging of the eye. The non-mydriatic, non-contact u-WF photographic imaging system includes an illumination system that delivers trans-pars-planar illumination to the eyeball. This frees the entire pupil to be used for imaging. Freeing the entire pupil to be used for imaging allows a u-WFC of the non-mydriatic, non-contact u-WF photographic imaging system to use a relatively simple optics system to capture an ultra-wide FOV. Eliminating the need to dilate the pupil and the need to make contact with the eye while performing imaging eliminates the many problems associated with mydriatic, contact-mode fundus imaging systems and methods. In addition, the system can be implemented in a way that makes it highly suitable for telemedicine applications in underserved areas where clinics and trained healthcare providers may not be available.
Patent EP-3645319-A1 (EP)
Title: Tyre provided with an object attached to the surface thereof
Inventor: LEBRUN XAVIER
IPC: B60C13/00
Filed: 2018-06-11
Abstract: The invention concerns a tyre provided with an object attached to said tyre, said tyre comprising, at the interface between the tyre and the attached object, an adhesive layer with a thickness of between 1 and 5 mm, characterised in that said adhesive layer is made from a self-adhesive silicone composition. The invention also concerns the method for attaching an object to a tyre comprising the steps of applying, to the object and/or to the tyre, an adhesive layer comprising a self-adhesive silicone composition, said adhesive layer having a thickness of between 1 and 5 mm; and of joining the object and the tyre.
Patent EP-3568467-A1 (EP)
Inventor: MAUS MARCELA V
IPC: A61K35/17
Filed: 2018-01-10
Abstract: The technology described herein relates to modified T cells and their use in immunotherapeutic methods. In various examples, the T cells are modified so as to decrease or eliminate ΟD3ζ, TRAC, and/or TRBC expression.
Patent EP-3572397-A1 (EP)
Inventor: SOMEYA Yuuichi
IPC: C07B61/00
Filed: 2018-01-18
Abstract: A method for producing N-(α-hydroxyethyl)formamide which comprises reacting formamide with acetaldehyde in a solvent in the presence of a basic catalyst in a reaction vessel, precipitating the obtained N-(α-hydroxyethyl)formamide in the reaction vessel, and collecting the precipitated N-(α-hydroxyethyl)formamide from the reaction vessel. The production of N-(α-hydroxyethyl)formamide is conducted multiple times using the same reaction vessel so that an (n+1)th reaction is conducted in the reaction vessel in which crystals of the N-(α-hydroxyethyl)formamide obtained in the n-th reaction are present (n is a natural number).
Patent EP-3661659-A1 (EP)
Inventor: GÖRTZ HENRY
IPC: B05C3/18
Filed: 2018-07-11
Abstract: The invention relates to a device (1) for coating a metal strip substrate (2) on one side and/or on both sides, comprising: a guiding apparatus (3) for guiding the strip substrate (2) along a specified movement path; a first coating apparatus (5) for coating a first main side (6) of the strip substrate (2) with an electrostatically charged coating powder (8) stored in a fluidized state, the first coating apparatus (5) being arranged at least partly geodetically under a first path section of the movement path; a second coating apparatus (9) for coating a second main side (10) of the strip substrate (2) with an electrostatically charged coating powder (8) stored in a fluidized state, the second coating apparatus (9) being arranged after the first coating apparatus (5) with respect to a direction of travel of the strip substrate (2) along the movement path; and a redirecting unit (12) for redirecting the strip substrate (2), the first path section transitioning into a second path section of the movement path by means of the redirecting unit (12), the redirecting unit (12) redirecting the strip substrate (2) in such a way that the strip substrate (2) in the second path section travels oppositely to the strip substrate (2) in the first path section, and the second coating apparatus (9) being arranged at least partly geodetically under the second path section.
Patent EP-3510070-A1 (EP)
Inventor: ASIRVATHAM EDWARD
IPC: C08G18/79
Filed: 2018-06-22
Abstract: Caprolactam-derived solvents for use as processing solvents and/or coalescing agents for polyurethane dispersions (PUDs). The caprolactam-derived solvents are suitable for processing solvents and coalescing agents in PUDs created through traditional PUD manufacturing processes or as coalescing agents in PUDs created through solvent-free PUD manufacturing processes. Blends of more than one caprolactam-derived solvent may be used as the processing solvent and/or coalescing agent.
Patent EP-3658652-A1 (EP)
Inventor: HOCH LARRY E
IPC: C10L5/36
Filed: 2018-07-17
Abstract: A wax composition can be incorporated into a biomass mixture, such as a woody biomass mixture, for formation of pellets, such as wood fuel pellets. The addition of wax compositions with suitable amounts of n-paraffins relative to the amount of oil-in-wax can result in biomass pellets with improved properties, such as improved durability and/or reduced tendency to uptake moisture during storage. Addition of a suitable wax composition can also allow for formation of biomass pellets with improved properties while also reducing or minimizing the power requirements during pellet formation.
Patent EP-3685289-A1 (EP)
Inventor: HÖLLER BERNHARD
IPC: G06F21/32
Filed: 2018-08-13
Abstract: A method for verifying the identity of a person and providing user data linked thereto, characterized by the following steps: a) capturing at least one biometric characteristic (100) of the person by means of a scanner (200) intended therefor, b) storing the biometric characteristic (100) captured in step a) as a biometric reference characteristic (110) in a centralized memory (300), c) linking the at least one biometric reference characteristic (110) with a user data record (410) of an external facility (400) for example, banking institutions, d) capturing the at least one biometric characteristic (100) using a scanning device (500) intended therefor, e) reading the biometric reference characteristic (110) from the centralized memory (300) and subsequently comparing the captured biometric characteristic (100) and/or bar code (101) from step d) with the biometric reference characteristic (110), and f) if the reference characteristic (110) matches the biometric characteristic (100) captured in step d), retrieving and providing the user data record (410), linked with the biometric reference characteristic (110), of the external facility (400).