baber/WOPTO huggingface dataset:
Patent CR-20110632-A (CR)
Title: Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes
Inventor: BRUNCKO MILAN
IPC: C07D471/04
Filed: 2011-11-25
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
Patent CR-20120556-A (CR)
Title: Composiciones farmacéuticas y métodos para su elaboración
Inventor: GUPTA MANISH K
IPC: A01N43/56
Filed: 2012-11-01
Abstract: Se describen composiciones farmacéuticas que incluyen una cantidad de una sal de adición de ácido de pazopanib equivalente a 10 miligramos/mililitro de pazopanib, y del 2 al 13 por ciento en peso/peso de una ciclodextrina modificada adecuada para utilizarse en una formulación oftálmica, así como métodos para la elaboración de las mismas.
Patent CR-20180084-A (CR)
Title: Productos de cacao basados en granos de cacao no fermentados y métodos para la preparación de los mismos
Inventor: HÜHN TILO
IPC: A23G1/32
Filed: 2016-07-08
Abstract: Se desvela un método para el procesamiento de los granos de cacao no fermentados, que comprende las etapas de: (a) añadir agua a dichos granos de cacao no fermentados para formar una suspensión; (b) triturar en húmedo dicha suspensión; (c) someter dicha suspensión a un tratamiento térmico a una temperatura de 70 °C o inferior; (d) separar la suspensión en una fase acuosa (fase pesada), una fase grasa (fase ligera) y una fase sólida, comprendiendo dicha fase grasa manteca de cacao como componente principal y sólidos y/o agua como componentes secundarios y comprendiendo dicha fase sólida polvo y agua; y (e) procesar por separado las tres fases, que comprende opcionalmente: separar la manteca de cacao de la fase grasa, separar el polvo de cacao de la fase sólida y separar el aroma de cacao y un polvo polifenólico de al menos la fase acuosa. Adicionalmente, se divulgan métodos para la fabricación de un kit de construcción de productos de cacao y productos de chocolate o similares a chocolate que comprenden altas cantidades de componentes nutricionalmente beneficiosos y útiles del fruto de cacao, tales como, por ejemplo, polifenoles, antioxidantes, vitaminas y/o azúcares, que hacen uso de la técnica anterior
Patent CR-20180243-A (CR)
Title: Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso
Inventor: DRAGOVICH PETER;
IPC: C07K16/32
Filed: 2016-09-30
Abstract: La invención proporciona conjugados de anticuerpo-fármaco que comprenden un anticuerpo conjugado con un resto de fármaco de pirrolobenzodiazepina mediante un enlazador disulfuro, intermedios de enlazador-fármaco de pirrolobenzodiazepina y métodos de uso de los conjugados de anticuerpo-fármaco.
Patent CR-20220374-A (CR)
Title: Methods of treating splenomegaly
Inventor: ROTHBAUM WAYNE PHILIP
IPC: A61P29/00
Filed: 2021-01-08
Abstract: Therapeutic methods and pharmaceutical compositions for treating splenomegaly in a human subject are described. In certain embodiments, the invention includes therapeutic methods of treating splenomegaly using a BTK inhibitor.
Patent CR-20220609-A (CR)
Title: Lpa receptor antagonists and uses thereof
Inventor: FARAND JULIE
IPC: C07D249/06
Filed: 2021-05-13
Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
Patent EC-SP045237-A (EC)
Title: Maquina y proceso para reciclar basura inorganica y obtener una pasta moldeable para diversos usos
IPC: B29B17/00
Filed: 2004-08-18
Abstract: La presente invención se refiere a una máquina y a un proceso para reciclar basura inorgánica y orgánica y obtener una pasta moldeable para diversos usos. Esta máquina está conformada básicamente por un pistón hidráulico, un plato empujador, una cámara receptora, un reactor, una bomba y un equipo calefactor.A su vez, dicha máquina va inherente a un proceso cuyas etapas son esenciales para obtener una pasta moldeable caliente con las características adecuadas, que, al enfriarse, se transforma en productos sustitutos de la madera y materiales para la construcción, como ladrillos, bóvedas, pisos, adoquines, tejas, etc. A estos productos no los ataca la humedad ni la polilla, no se pudren y se pueden cortar, maquinar o tornear. Esta máquina no requiere de agua en el proceso industrial ni lavar o higienizar la basura que transforma o procesa, no contamina y tiene bajo costo de operación, pues es eficiente y puede ser operada por una sola persona. Esta invención beneficiará a la sociedad y al medio ambiente, puesto que la basura podrá ser reutilizada y evitará el usar y acabar con los recursos naturales.
Patent EC-SP066752-A (EC)
Title: Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil]-benzamida
Inventor: MANLEY PAUL WILLIAM
IPC: C07D401/04
Filed: 2006-08-03
Abstract: La presente invención se refiere a las sales de adición de ácido de 4-[4-metil-1-piperazinilmetil]-N-[4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]fenil]-benzamida, que se seleccionan del grupo que consiste de una sal de tartrato, tal como una sal de (D)(-)tartrato o sal de (L)(+) tartrato, sal de clorhidrato, sal de citrato, sal de malato, sal de fumarato, sal de succinato, sal de benzoato, sal de bencensulfonato, sal de pamoato, sal de formiato, sal de malonato, sal de 1,5-naftalendisulfonato, sal de silicato, sal de ciclohexansulfamiato, sal de lactato, sal de mandelato, sal de glutarato acuosa, sal de adipato, sal de escuarato, sal de vanilato, sal de oxaloacetato, sal de ascorbato, y sal de sulfato.
Patent EC-SP930916-A (EC)
Title: Cassete seda dental
Inventor: BENITEZ VITE WALTER ARMANDO
IPC: A61C15/04
Filed: 1993-03-19
Abstract: El invento consiste en: -Una caja de material plástico con medidas de 40mm X 22mm x 6mm que cumple con las funciones a ella encomendadas protegiendo, principalmente, a la seda dental que por encontrarse en el interior de la misma se mantiene debidamente protegida del medio ambiente, permitiéndole al paciente más confianza en el uso de ella. Carretes dentados de 16mm de diámetro con ejes de alto por 4mm de diámetro que separados por un selector son gobernados por este y permiten el avance o la fijación de la seda dental para soportar la suficiente presión al momento de la limpieza bucal.
Patent EC-SP982575-A (EC)
Title: Forma polimorfica de un antagonista de receptor de taquiquinina
Inventor: MCCAULEY JAMES A
IPC: C07D295/00
Filed: 1998-07-02
Abstract: Esta invención tienen que ver con una forma polimórfica nueva del compuesto 2-®-(-1(R]-(3,5-bis(trifluorometil)-fenil)-etoxi-3-(S)-(4-fluoro) fenil-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)metilmorfolina, el cual es un antagonista de receptor de taquiquinina útil en el tratamiento o prevención de trastornos del sistema nervioso central, enfermedades inflamatorias, dolor o migraña, asma y emesis. La forma polimórfica instantánea tiene ventajas sobre las toras formas conocidas de 2-(R)-(1(R)-(3,5-bis(trifluro-metil)-fenil)-etoxi-3-(S)-(4-fluoro)fenil-4-(3-(5--oxo-1H,4H-1,2,4-triazolo-metilmorfolina en términos de estabilidad termodinámica e idoneidad para su inclusión en formulaciones farmacéuticas.
Patent FI-20000061-A (FI)
Inventor: MULLER GEORGE W
IPC: C07D471/04
Filed: 2000-01-12
Abstract: Imido and Amido substituted alkanohydroxamic acids reduce the levels of TNFa and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.
Patent FI-20000542-A (FI)
Inventor: AALTO MIKA
IPC: H04L49/111
Filed: 2000-03-09
Abstract: This invention relates to a system for adapting transmission capacities of a packet-switched network, the system comprising at least two switches (11, 11', 31, 32) and at least two successive transmission connections with different transmission capacities between said switches (11, 11', 31, 32), characterized in that the system also comprises means (12, 12', 33, 34, 35) for comparing the transmission capacities of the transmission connections at the junction of two transmission connections with different transmission capacities, means (12, 12', 33, 34, 35) for transmitting information on the real transmission capacity available from said junction at least to the switch (11, 11', 31, 32) in the direction of higher transmission capacity, the real transmission capacity being determined according to the transmission connection with lower capacity, and means for taking the information on the transmission capacity into account in the switch (11, 11', 31, 32) which received it when a new connection is established.
Patent FI-20002774-A (FI)
Inventor: VIRTANEN TAUNO
IPC: D21F7/10
Filed: 2000-12-18
Abstract: A method of making a press felt, a press felt and a base fabric. The base fabric comprises a surface component on the surface facing the paper web to be dried and a base component below the surface component. The transverse jointing edges of the base component are provided with seam loops, by means of which the base component can be connected into a closed loop. At the first jointing edge of the base fabric the surface component extends for a predetermined distance longer than the base component and forms a seam flap that protects the seam area of the base component.
Patent FI-20011774-A (FI)
Inventor: AUTERO MARKKU
IPC: B62K5/05
Filed: 2001-09-07
Abstract: The present invention relates to a bicycle or a kickboard (1) equipped with two front wheels (20). The bicycle or kickboard (1) comprises a rear frame (3) and a front frame (2), said front frame (2) including elongated suspension arms (2c, 2d) extending a distance in a substantially transverse direction relative to a centre axis (A, B) and having the ends thereof provided with gearing-mounted and/or articulated bearing supports (4a, 4b) for the front wheels (20). The front frame (2) has provided therewith a handlebar (6), as well as steering elements (7, 8, 9, 10, 11) between the handlebar (6) and the bearing supports (4a, 4b) for steering the bicycle or kickboard (1). The steering elements (7, 8, 9, 10, 11) include: a frame hinge, a connecting link or the like (5), which is provided between the front frame (2) and the rear frame (3) and as a result of whose function the position of the front frame (2) and/or the centre axis (B) of the front frame (2) is pivotable relative to the rear frame (3) and/or the centre axis (A) of the rear frame (3). The steering elements further include tie rods or the like (8, 9), by way of which the handlebar (6) is coupled with the bearing supports (4a, 4b) for steering the bicycle or kickboard (1) in response to the handlebar (6) regardless of a pivoted position of the front frame (2) with respect to the rear frame (3). <IMAGE>
Patent FI-20065700-A (FI)
Inventor: HYVAERINEN VEIKKO
IPC: H02J3/38
Filed: 2006-11-06
Abstract: A method and an arrangement in connection with a wind power plant, an electric drive of the wind power plant comprising two or more partial converters in parallel, which constitute a frequency converter of the electric drive, and each partial converter comprising a mains converter part, of which the nominal power of at least one differs from the nominal power of other mains converter parts, and in the method there is selected for use the smallest possible, individual mains converter part required by an operating point of the wind power plant, or a combination of mains converter parts.
Patent FR-1605071-A (FR)
Title: Plastic lenses having paraboloid surface esp contact
IPC: G02C7/04
Filed: 1967-02-13
Granted: 1973-01-12
Abstract: Manufacture of plastic lenses with non-spherical surfaces, esp. contact lenses, but also photographic, analytical balance and magnifying glass lenses, etc. A mechanically formed blank is heated below its gel point, and reduced and formed mechanically to obtain surfaces having rotational symmetry, esp. spherical, cylindrical or bullet-shaped, then allowed to relax by heating above the gel point or by swelling. The materials used are polymers which are crosslinked, pref. incompletely, e.g. of methyl acrylate. Plastic lenses having paraboloid, surface may be produced by this method.
Patent GB-1047202-A (GB)
IPC: C25D3/16
Abstract: 1,047,202. Nickel plating baths. J. PRESTON & CO (CHEMICALS) Ltd. Feb. 4, 1964 [Feb. 12, 1963], No. 5691/63. Heading C7B. A nickel plating bath includes 1-butyne-3-ol, 2-propene-1-sulphonic acid sodium salt, at least 50 g of H 3 BO 3  per litre and a sulphonic acid or salt thereof or a sulphonamide or sulphonimide. A range of sulpho-compounds are specified e.g. mono- and poly-nuclear, and hetero-cyclic sulphonic acids, their amides, and salts e.g. of alkali metals, ammonia. Mg andNi. The boric acid concentration is preferably near to saturation. Ni plating salts are sulphate, chloride, formate, fluoborate, and sulphamate. Other additions are Nacl, and NaBr.
Patent GB-1047231-A (GB)
IPC: G01C15/00
Abstract: 1,047,231. Optical apparatus. A. LORAND. July 8, 1964 [July 12, 1963], No. 27703/63. Heading G2J. [Also in Division H4] A light beam transmitter comprises a light source 11 and a parabolic mirror 14 for focusing an image of at least part of source 11 at a distance from the transmitter, the parabolic mirror 14 having a surface which is accurate to within one, preferably to within one tenth, of a wavelength of visible light. As shown the tungsten wire filament 12 of source 11 is in the form of a helix so as to produce a line of intense light. This line may be arranged to be horizontal and the apparatus used as surveying apparatus replacing a sighting level, by providing a receiver 21, Fig. 4, (not shown), in the form of three flat tubes 22-24 which are open at one of their ends and have light sensitive elements 25-27 at their other ends. The receiver 21 is rotatable on a central post 30 which can be raised or lowered by a reversible electric motor 31 acting through gearing 32 and rack and pinion drive 33, a controlling circuit 34 and bridge circuit 35 having elements 25, 27 in two of its arms, being such that when the level of illumination falling on element 26 reaches a suitable level, the bridge circuit 35 is energized and motor 31 controlled so that relay 37 stops the motor 31 when the central tube 23 is aligned with the projected beam. In an alternative form,Fig. 7,(not shown),a single flat tube is provided with an opening 120 at one end and a light-sensitive element 121 at the other. The tube is raised and allowed to fall under gravity and in so doing operates a height counter 123 through an electromagnetically controlled clutch 128 which is disconnected by Schmitt trigger circuit 122 when the light from the transmitter impinges an element 121. In alternative applications the transmitter is used to provide infra-red beams and may be used for blind-landing or direction-finding devices fitted to aircraft or space vehicles or used with shipping to provide navigational information, automatic steering or speed control in narrow waterways.
Patent GB-1053869-A (GB)
IPC: D02G1/14
Abstract: 1,053,869. Crimping yarns. MONSANTO CO. Aug. 17, 1964 [Aug. 21, 1963], No. 33520/64. Heading D1F. Multifilament yarn is textured in a single pass through ap air of meshed crimping gears. The yarn is drawn by the positively driven gears from a heated snubbing pin and passes around part of the periphery of one gear to spread into a filament sheet thereon before being engaged in the mesh. The longitudinal axis of the pin may be skewed with respect to the rotational axes of the gears in order to locate positively the point of contact between yarn and gears.
Patent GB-1054324-A (GB)
IPC: C07C51/487
Abstract: 1,054,324. Purification of aliphatic acids. LANKRO CHEMICALS Ltd., D. BUTLER, and A. GILL. Sept. 10, 1964 [Sept. 11. 1963], No. 35879/63. Heading C2C. Saturated aliphatic acids (2-10 C atoms) e.g. propionic acid are purified by halogenating the impurities in the acid and separating the impurities e.g. by distillation. Chlorine or bromine may be used and the product after separation of the chlorinated impurity may be further halogenated e.g. to 2,2-dichloropropionic acid with improved yield.
Patent GB-1143888-A (GB)
IPC: D03J5/06
Abstract: 1,143,888. Gripper shuttles; looms. SULZER BROS. Ltd. 7 Nov., 1967 [22 Nov. 1966], No. 50619/67. Heading D1E. A gripper shuttle has a heavy solid metal head portion 39 and a synthetic plastics body 40, 41 surrounding the gripper 37. The plastics portion may extend to cover the head portion and prevent metal-to-metal contact and consequent wear during shuttle flight.
Patent GB-1225858-A (GB)
IPC: B60K17/22
Filed: 1968-09-19
Abstract: 1,225,858. Motor vehicles. VAUXHALL MOTORS Ltd. 3 July, 1969 [19 Sept., 1968], No. 44583/68. Heading B7H. The engine 12, clutch 14 and gear mechanism 16 are resiliently pivotally mounted as at 18 transversely of the body of a vehicle and are rigidly coupled to a drive-shaft 24 the opposite end of which is fixedly secured to the input shaft of a differential unit 34. The shaft 24 is of a sufficiently large diameter to resist bending such that any movement of the rear axle unit causes the assembly to pivot as a whole about the pivots 18. The back axle unit may comprise a rigid live axle supported by helical springs 44 at each end to the body of the vehicle. A Panhard rod may locate the axle in a lateral sense. Alternatively independent rear wheel suspension may be employed and a De Dion tube may be used to support the rear wheels and to which the coil springs are attached to support the back axle on the body of the vehicle, Fig. 4, not shown.
Patent GB-1226037-A (GB)
IPC: G01B3/18
Filed: 1968-10-02
Abstract: 1,226,037. Micrometers. G.K.N. SHARDLOW METROLOGY Ltd. Oct.14, 1969 [Oct.2, 1968], No.46737/68. Heading G1M. A micrometer comprises an external sleeve 28 rotatably surrounding a portion of a thimble 22, a ratchet 56, 58 provided around the internal surface of the sleeve and a pawl 69 formed by the free end of a spring 64 secured at its other end to the thimble and extending around an annular space between the ratchet and the thimble so that the pawl bears resiliently on the ratchet. When the sleeve is rotated in one direction the pawl abuts an edge of one of the teeth 56 to rotate the thimble but rotation of the sleeve in the other direction only causes rotation of the thimble as long as tne resistance to rotation of the thimble is insufficient to overcome the frictional engagement of the pawl with the ratchet teeth.
Patent GB-1227356-A (GB)
IPC: E05F11/04
Filed: 1967-07-14
Abstract: 1,227,356. Window and door operating mechanisms. HENRY HOPE & SONS Ltd. 10 July, 1968 [14 July, 1967], No. 32558/67. Heading E2M. [Also in Division F2] Window, door, or ventilator operating gear comprises a flexible drive cable 12 extending into a housing 10 to engage a gear wheel 14 which is rotated when the cable is moved longitudinally, a longitudinally grooved drum 15 secured for rotation with the gear wheel 14, and a chain 26 of the type is flexible in one direction only from straight, so that it can form a strut extending from the housing for connection to the window, &c to be moved, the chain being wound helically on to the drum 15. A helical wire coil 25 on the drum acts as a guide for the chain 26, the links of which have teeth 28 which engage in the drum grooves. Abutments 27 on the links interengage to prevent flexing of the chain in one direction from straight. The cable 12 has a wire wound helically round a core, to form a flexible rack which engages teeth 19 of the gear wheel 14. The cable is actuated by known means (not shown).
Patent GB-1227716-A (GB)
IPC: G06K13/30
Filed: 1970-01-21
Abstract: 1,227,716. Cinematographic apparatus. PHILIPS ELECTRONIC & ASSOCIATED INDUSTRIES Ltd. Jan. 21, 1970 [Jan. 24, 1969], No.2974/70. Heading G2E. In a claw feed mechanism for use with perforated film, claws 11, 12 are carried on an arm 9 pivoted at 10 on an armature 6 which is attracted against spring 18 to soft iron cores 3, 4 of electromagnet 1 including a permanent magnet 2 until coil 5 is energized to overcome the magnetic attraction and allow armature 6 to be drawn towards film 7 by spring 18 to engage perforations 13, the arm 9 having a reciprocatory motion imparted by the engagement of slat 14 with crank-pin 15 on rotating disc 16.
Patent GB-1227739-A (GB)
IPC: H01L23/488
Filed: 1967-09-18
Abstract: 1,227,739. Welding by pressure. JOSEPH LUCAS (INDUSTRIES) Ltd. 3 Sept., 1968 [18 Sept., 1967], No. 42367/67. Heading B3R. [Also in Division H1]  A lead 16 attached to a semi-conductor device 12 in a housing 11 passes out of the housing through a metal sleeve 15 mounted on a closure member. A part 15a of the sleeve 15 remote from the housing and the part of lead 16 enclosed thereby are flattened and then further pressure is applied to a central portion of the part 15a by electrodes 17 carrying an electrical current, so that the lead 16 is welded to the sleeve. The end portions of the part 15a of the sleeve remain unwelded to the lead 16, the parts of the lead 16 therein serving as plugs to resist the flow of molten metal from the welded region.
Patent GB-1228581-A (GB)
IPC: A01K27/00
Filed: 1967-02-09
Abstract: 1,228,581. Leads for animals. H. DREYFUSS. 9 May, 1968 [9 Feb., 1967], No.6341/67 Heading A1M. A lead e.g. for a dog includes a ring 3 at or adjacent one end, through which part of the lead may be passed to form a noose, a spring clip 4 releasably connectible to the lead for limiting the noose size, and an apertured disc 5. The lead may be of chain, or a length of leather, plastics or cord, the clip 4 in the latter case being optionally provided with serrated gripping jaws.
Patent GB-1228803-A (GB)
IPC: B29C41/00
Filed: 1968-06-26
Abstract: 1,228,803. Thermoset resin coatings. TRW Inc. 26 June, 1968 [30 June, 1967], No. 30568/ 68. Addition to 1,193,301. Heading B2E. An article having a coating of a thermoset resin is produced by forming a mixture containing a polyfunctional polydiene prepolymer having at least 50% of its olefinic unsaturation in the form of pendant vinyl groups on alternate carbon atoms of an elongate backbone carbon chain, a polyfunctional organic chain extender capable of reacting with the functional groups on the polydiene, and a peroxide free radical initiator capable of heat-curing the mixture to a thermoset resin, reacting the mixture to form by chain extension an elastomer having unreacted initiator dispersed therethrough, comminuting the elastomer, heating the article and contacting the comminuted elastomer therewith to form a coating of the elastomer thereon, and heating the coating to cure the elastomer to a thermoset resin. The polyfunctional polydiene may be dihydroxy-1,2-polybutadiene or dihydroxy 3,4-polyisoprene and the polyfunctional chain extender a diisocyanate, diacid halide, dicarboxy, or diester substituted aliphatic or aromatic compound; or dicarboxy 1,2 polybutadiene or dicarboxy 3,4- polyisoprene, and a diepoxide, diamine, diimine, dihydroxy, or diaziridine substituted aliphatic or aromatic compound. The initial mixture may also contain a polyfunctional polyether or hydrocarbon copolymer; and a filler material comprising synthetic fibers or fabric, carbon, asbestos, silica, glass, silicate, metal, metal oxide, or plastics material. The coating may be applied using a fluidized bed, by rolling the object in a bed of powder, or by pouring or spraying the powder over the heated object. Articles specified are a pump impellor blade, and the internal surface of a metal pipe.