Patent SG-11201804261W-A (SG)
Title: Compounds
Inventor: KRAFT PHILIP
IPC: C07C49/21
Filed: 2016-12-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) (43) International Publication Date .... ..1r„1 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO International 2017/097938 1111111111111111111111111111111111111111111111111111111111111t111111111111111 Publication Al Number (51) International Patent Classification: 5, 6315 Oberageri (CH). NATSCH, Andreas; Kleindorf- CO7C 49/21 (2006.01) strasse 44, 8707 Uetikon (CH). (21) International Application Number: (74) Agent: MCSTEA, John; Ueberlandstrasse 138, 8600 PCT/EP2016/080334 Dilbendorf (CH). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 8 December 2016 (08.12.2016) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, Kfl, KN, (30) Priority Data: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 1521682.3 9 December 2015 (09.12.2015) GB MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (71) Applicant: GIVAUDAN SA [CH/CH]; Chemin de la Par- NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, fumerie 5, 1214 Vernier (CH). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (72) Inventors: KRAFT, Philip; Kirchbachstrasse 4, 8600 ZA, ZM, ZW. Diibendorf (CH). EMTER, Roger; Buchholzstrasse 92, 8053 Zurich (CH). FLACHSMANN, Felix; Langhagweg (84) Designated States (unless otherwise indicated, for every 2, 8600 Diibendorf (CH). JORDI, Samuel; Hofmattstrasse kind of regional protection available): ARIPO (BW, GH, [Continued on next page] (54) Title: COMPOUNDS Figure 1 —I— (2E,1'R\",2'S i uc ion )-2-me -(2 _6 - —it— induction Damascene delta'\" trimethylcyclehex-3'-en-l'-yObut-2-en-1-one Tki —c-i-- viability (2E.1'IR . ,2'SI)-2-methyl-1-(2',6',6 - - —E— viability Damascene delta trimethylcyclehex-3'-en-1'-elliaut-2-en-l-one o 9.0 - ---- ---- ----------- .......... ---- ......... -------------------- 140 9.0 -------- ..... ---------- ........... ----- --------- — ----- ---- 140 7.5 120 7.5 0 a 0 100 0 ° 00 : 15 e-. - 6.0 .0 r = 0 I 0 0 i 0 4.5 4 51 0 IL' s0 ttoa 0 it: 0 .0 a 40 40 = -0 1.5 - a 2 \"i 5 - a 20 ._ LL 0.0 0 0.0 7. i 0 1 10 100 1000 10D 1000 Concentration (A Concentration (41) ,R ,-' 0 li .4t GC en Ct N 01 C:: , IN - 0 N z. R2 R4-.. R 3 . ) il n ( I) [Continued on next page] O WO 2017/097938 Al MIONIMOREMIMOIDEHONHEIEMIDERREVOIME GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT Published: , LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, — with international search report (Art 21(3)) (57) : A compound of foiinula (I), in which, independently, R 1 is selected from H and methyl; R2 is selected from H, and methyl; R3 is selected from H, methyl and ethyl; R4 is selected from H, methyl and ethyl; or R3 and R4 together foiin a ring in which n is 1 or 2. The compounds have the characteristic desirable odour qualities of the Damascone TM molecules, but lack their disadvantageous skin sensitization effects.