Patent SG-11201811709W-A (SG)
Title: Compounds, compositions, and methods for the treatment of disease
Inventor: IYER RADHAKRISHNAN
IPC: A61K31/7084
Filed: 2017-07-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 January 2018 (11.01.2018) WI P0 I PC T IiiimmomiolollmonoloololionolioommomovoimIE (10) International Publication Number WO 2018/009648 Al 00 71 O - LI- (51) International Patent Classification: A61K 31/7052 (2006.01) A61K 39/12 (2006.01) A61K 31/7084 (2006.01) (21) International Application Number: PCT/US2017/040882 (22) International Filing Date: 06 July 2017 (06.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/359,039 06 July 2016 (06.07.2016) US 62/363,118 15 July 2016 (15.07.2016) US 62/403,530 03 October 2016 (03.10.2016) US 62/411,424 21 October 2016 (21.10.2016) US 62/444,141 09 January 2017 (09.01.2017) US 62/462,679 23 February 2017 (23.02.2017) US 62/470,746 13 March 2017 (13.03.2017) US 62/508,846 19 May 2017 (19.05.2017) US (71) Applicant: SPEROVIE BIOSCIENCES, INC. [US/US]; 113 Cedar Street, Milford, MA 01757 (US). (72) Inventors: IYER, Radhakrishnan, P.; 15 Quail Hollow Drive, Shrewsbury, MA 01545 (US). SHERI, Anjaneyu- lu; 12 Pheasant Hill Drive, Shrewsbury, MA 01545 (US). PADMANABHAN, Seetharamaiyer; 67 Fottler Avenue, Lexington, MA 02420 (US). MEHER, Geeta; 4 Capital Road #1, Milford, MA 01757 (US). ZHOU, Shenghua; 21 Stoney Hill Road, Shrewsbury, MA 01545 (US). CHAL- LA, Sreerupa; 3132 Arbor Dr., Shrewsbury, MA 01545 (US). GIMI, Rayomand, H.; 41 Stonegate Road, Chelms- ford, MA 01824 (US). CLEARY, Dillon; 99 Spruce Street, Middleborough, MA 02346 (US). (74) Agent: GORDON, Dana, M. et al.; Foley Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) (54) Title: COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE 10000 cn 'too 10 1 T ▪ ern iss ue c Cr, ...I- ix, ▪ co co co o CV CO CM CO P.- 0 0 0 CV Cr) ..er L0 CON-CO 0 0 CV CO \"V- CI_ C.1 CV CV CV CV CV CV CV CV CV CI CI Cr, Cr> EEEEEEEEEco_to-co_co_co_co_ C=L CL CL 0_ CL CL CL CL CL CL CL CL CL CL CL CLcD c)c..)c_3(_3(\"c_)c_3(_)c_)EeEEEEEEEEEEEEEEEEEEEEEEEc_a C-D C_D C_D CD C_D C-3 C-1. C-3 C-3 C-3 C-D c-3 c-D c-3 C.D C.D C-D C-D -ro FIG. 1A 25µM Compound O O (57) : Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.