Patent SG-11201808582R-A (SG)
Title: Pyrrolotriazine compounds as tam inhibitors
Inventor: LI YUN-LONG
IPC: C07D487/04
Filed: 2017-03-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIM141101110101011111 HO 111110111010111111111111111111111111111111111110111111 International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/172596 Al 5 October 2017 (05.10.2017) WI P0 I P CT (51) International Patent Classification: Delaware 19803 (US). MEI, Song; Incyte Corporation, C07D 487/04 (2006.01) A61K 31/519 (2006.01) 1801 Augustine Cut-Off, Wilmington, Delaware 19803 A61P 35/00 (2006.01) (US). ZHUO, Jincong; Incyte Corporation, 1801 Au- gustine Cut-Off, Wilmington, Delaware 19803 (US). (21) International Application Number: PCT/US2017/024270 (74) Agents: KING, Annie J. et al.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (22) International Filing Date: 27 March 2017 (27.03.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 62/314,066 28 March 2016 (28.03.2016) US KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 62/362,934 15 July 2016 (15.07.2016) US MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/438,750 23 December 2016 (23.12.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: INCYTE CORPORATION [US/US]; 1801 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, Augustine Cut-Off, Wilmington, Delaware 19803 (US). TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: LI, Yun-Long; Incyte Corporation, 1801 Au- gustine Cut-Off, Wilmington, Delaware 19803 (US). (84) Designated States (unless otherwise indicated, for every _ WANG, Xiaozhao; Incyte Corporation, 1801 Augustine kind of regional protection available): ARIPO (BW, GH, — Cut-Off, Wilmington, Delaware 19803 (US). BARBOSA, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, _ Joseph; Incyte Corporation, 1801 Augustine Cut-Off TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Wilmington, Delaware 19803 (US). BURNS, David M.; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, = Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, L Delaware 19803 (US). FENG, Hao; Incyte Corporation, V, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 1801 Augustine Cut-Off, Wilmington, Delaware 19803 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = (US). GLENN, Joseph; Incyte Corporation, 1801 Au- GW, KM, ML, MR, NE, SN, TD, TG). gustine Cut-Off, Wilmington, Delaware 19803 (US). HE, Published: Chunhong; Incyte Corporation, 1801 Augustine Cut-Off, — = Wilmington, Delaware 19803 (US). HUANG, Taisheng; with international search report (Art. 21(3)) Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, — with sequence listing part of description (Rule 5.2(a)) = = (54) Title: PYRROLOTRIAZINE COMPOUNDS = = = _ = _ N AS NH 2 TAM INHIBITORS H 1 N / C CY B Cy I 0 ,-, R3N o, ir) ei IN ,-1 IN 1-1 (57) : This application relates to compounds 0 of TAM kinases which are useful for the treatment ei of of disorders such as cancer. N R1 I Formula I, or pharmaceutically acceptable salts thereof, which are inhibitors O