baber/WOPTO huggingface dataset:
Patent CA-2839755-A1 (CA)
Title: Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer
Inventor: GUJRAL TARAN S
IPC: C07K16/28
Filed: 2012-06-15
Abstract: Disclosed herein are methods of treating cancer in a subject, and methods for inhibiting growth, migration and/or invasion of a cancer cell in the subject, comprising administering to the subject a therapeutically effective amount of an antibody or antigen binding fragment thereof that downmodulates Fzd2. The antibody may specifically bind Fzd2, and may promote internalization of the Fzd2 receptor by the cancer cells and/or prevent ligand binding to Fzd2. Specific antibodies, and also specific portions of the Fzd2 molecule for antibody binding are disclosed. In one embodiment the antibody specifically binds to the epitope HGAEQICVGQNHSEDGAPAL (SEQ ID NO: 1). Specific cancers (e.g. late stage hepatocellular carcinoma), intended for treatment are provided, and include cancers that exhibit overexpression of Fzd2, and/or Wnt5a.
Patent CA-2843167-A1 (CA)
Title: Anchor channel
Inventor: HEUDORFER MARKUS
IPC: E04G21/18
Filed: 2012-06-12
Abstract: Anchor rail having a rail body (1), with a multiplicity of identical fastening locations (20, 20', 20") and having a multiplicity of identical anchor bodies (30), which are fastened on the rail body (1) at the fastening locations (20, 20'). According to the invention, it is provided that an additional element (40) is fastened at at least one of the fastening locations (20"'), with said additional element differing from the identical anchor bodies (30).
Patent CA-2843460-A1 (CA)
Inventor: PULYASSARY RAVINDRAN
IPC: A63F1/00
Filed: 2011-01-21
Abstract: An active learning system comprises a plurality of learning modules whose contents together make up a predetermined corpus of knowledge to be learned by the participant(s), a corresponding plurality of sets of questions/facts relating to the learning modules, respectively, and rules prescribing a sequence of events constituting a learning session having a learning session start and a learning session finish. The events may comprise selecting at least some of said learning modules individually and successively, selecting one of the set of related questions/facts for the participant to answer, and recording progress of the participant from a learning session start towards a learning session finish according to whether or not the participant answers the selected questions correctly. The progress chart preferably is appropriate to the subject to be learned; for example the Periodic Table of Elements for chemistry, DNA sequences for molecular biology, Canada's Food Plan for nutrition, and so on. An active learning educational card game comprises a set of cards and rules for playing at least one card game using them. Each of the cards represents a respective one of the chemical elements listed in the Periodic Table of Chemical Elements and carries information about that chemical element. The rules prescribe for cards to be distributed to the players who, in their turns in a particular round of the game, attempt to use the cards to form chemical compounds, points being scored according the nature of the cards used or the nature of the compound formed, or both. Players may substitute cards from the same column, or within a defined group of individual elements or with cards from well-defined groups satisfying some specific criteria.
Patent CA-2844125-A1 (CA)
Inventor: HEMMER NATHAN ANDREW
IPC: F21V21/34
Filed: 2014-02-28
Abstract: A track and carriage system including a mounting plate, a first track removably secured to the mounting plate and receiving a first carriage movable therein, a second track removably secured to the mounting plate and receiving a second carriage movable therein. The first and second tracks are positioned adjacent and substantially parallel to one another such that the carriage of the first track moves independently of and in parallel with the carriage of the second track.
Patent CA-2844354-A1 (CA)
Title: Image-domain 4d-binning method and system
Inventor: HAACKE ROSS
IPC: G01V1/28
Filed: 2014-03-03
Abstract: A method for increasing similarity between a base seismic survey and a monitor seismic survey of a same surveyed subsurface during a 4-dimensional (4D) project. The method includes receiving first seismic data associated with the base seismic survey; receiving second seismic data associated with the monitor seismic survey, wherein the monitor seismic survey is performed later in time than the base seismic survey; migrating the first and second seismic data to an image-domain; and calculating, with a processor, a set of decimating weights based on the migrated first and second seismic data in the image-domain, to maximize a similarity between the first seismic data and the second seismic data.
Patent CA-2845849-A1 (CA)
Inventor: BHATTACHARYYA DIBAKAR
IPC: C02F1/72
Filed: 2014-03-12
Abstract: A chemical processing cell includes an upstream membrane and a downstream membrane. The upstream membrane generates a first reaction product. The downstream membrane converts the first reaction product to a second reaction product.
Patent CA-2846816-A1 (CA)
Title: Systeme detecteur et procede pour determiner des parametres de qualite de feuille de papier
Inventor: VAN MECHELEN JACOBUS LODEVICUS MARTINUS
IPC: G01N21/3559
Filed: 2014-03-14
Abstract: Un système de capteur sans contact et une méthode de détermination de paramètres de qualité de papier, comme le calibre, le poids de base et lhumidité en fonction du rayonnement THz, sont décrits. La méthode comprend : lémission par un système émetteur dun signal de rayonnement THz vers le matériau de la feuille de papier, de sorte que le rayonnement THz interagisse avec ledit matériau; la détection par un système détecteur dune réponse dépendant du temps et/ou de la fréquence du signal de rayonnement THz ayant interagi avec le matériau; la détermination de paramètres modèles dun modèle physique en optimisant les paramètres modèles, de sorte que la réponse prévue du modèle physique soit ajustée à la réponse détectée, les paramètres modèles indiquant les coefficients de transmission et/ou de réflexion aux interfaces du matériau avec les substances avoisinantes; et la détermination, à partir des paramètres modèles déterminés, dau moins certains paramètres de qualité de la feuille de papier.
Patent CA-2847624-A1 (CA)
Inventor: YONEOKA TAKATOMO
IPC: A61P21/02
Filed: 2012-09-05
Abstract: La présente invention concerne un nouvel agent médicinal et un nouveau procédé qui peuvent tous deux être utilisés pour traiter la SLA (sclérose latérale amyotrophique), prévenir l'évolution de la phase de SLA, traiter un symptôme associé à la SLA, ou prévenir l'évolution de la phase du symptôme, et tous deux pouvant être en particulier appliqués à des patients qui peuvent être traités très efficacement par l'agent médicinal ou le procédé parmi l'ensemble des patients atteints de SLA qui nécessitent un traitement. La présente invention concerne un agent médicinal qui peut être utilisé pour traiter la sclérose latérale amyotrophique, prévenir l'évolution de la phase de la sclérose latérale amyotrophique, traiter un symptôme associé à la sclérose latérale amyotrophique, ou prévenir l'évolution de la phase du symptôme. L'agent médicinal comprend de la 3-méthyl-1-phényl-2-pyrazolin-5-one ou l'un de ses sels physiologiquement acceptables comme ingrédient actif, il est administré de telle sorte qu'une période d'administration de dose de 14 jours et une période de lavage de 14 jours soient répétées alternativement ou de telle sorte qu'une période d'administration de dose initiale de 14 jours et une période de lavage de 14 jours consécutive soient appliquées et qu'ensuite, une période d'administration de dose dans laquelle l'administration de dose est effectuée pendant 10 jours quelconques sur 14 jours et une période de lavage de 14 jours soient répétées alternativement, et il est administré à un patient qui répond à des critères spécifiques.
Patent CA-2848220-A1 (CA)
Inventor: SNOWBALL MALCOLM ROBERT
IPC: A23C3/07
Filed: 2012-08-30
Abstract: A fluid steriliser comprising a fluid duct having a UV transmissive wall providing a surface area for irradiation, wherein the cross section of the duct is between 1x10-4 m2 and 5x10-2 m2 and the thickness of the duct defines the depth of fluid flow adjacent the UV transmissive wall of no more than 50mm; a source of UV radiation arranged to irradiate fluid flowing in the duct through the UV transmissive wall such that the UV radiation incident on fluid in the duct has a UV power density; a plurality of mixing stages configured to provide turbulent flow in the fluid and spaced apart along the length of the duct wherein the segments of the duct between the mixing stages are arranged to provide flow adjacent the UV transmissive wall; a flow control means arranged to control the linear speed of fluid flow along the duct based on the length of the duct and the UV power density so that at least 300 Joules of UV energy per square metre of the surface area for irradiation is provided to the fluid during the dwell time of the fluid in the duct.
Patent CA-2848472-A1 (CA)
Inventor: ROWE SIMON MICHAEL
IPC: G06F17/00
Filed: 2012-09-07
Abstract: A server computer receives web request events corresponding to web requests issued by users. Each web request event includes: a cookie that identifies the user computer that originated the corresponding web request; an IP address corresponding to the user computer; and a date/time stamp indicating when the corresponding web request was received at a web server. The server stores the web request events. The server selects a subset of the web request events, all of which are associated with the same cookie. Then the server computes a geographical location corresponding to the user computer, where the computation uses the IP address associated with the web request event. The server determines the local time and day of week corresponding to the web request. The server then classifies the user computer based, at least in part, on a usage pattern corresponding to the web request events in the subset.
Patent CA-2849122-A1 (CA)
Inventor: WHITT DAVID
IPC: C02F1/56
Filed: 2012-09-28
Abstract: A method for separating dispersed algae from an aqueous system is provided. The method includes adding to the aqueous system a polymer including tannin to form flocculated aggregates, and separating the flocculated aggregates from the aqueous system. A method for pretreating water comprising dispersed algae in an algae biofuel production system is also provided. The method includes adding to the water a polymer including tannin to form flocculated aggregates, and separating the flocculated aggregates from the water.
Patent CA-2849558-A1 (CA)
Title: Generateur de signaux de courant et procede de mise en oeuvre d'un tel generateur
Inventor: CUBAINES FABRICE
IPC: H02M1/08
Filed: 2012-09-21
Abstract: L'invention concerne un générateur de créneaux de courant, adapté pour fournir aux bornes d'une charge (7) des signaux de courant régulé, de polarité alternée, sous haute tension, comprenant : - une pluralité d'étages secondaires (20), comportant au moins une source de tension continue isolée des sources de tension des autres étages, connectés en série entre le point milieu du second (Q3, Q4) demi -pont de chaque étage secondaire et le point milieu du premier (Q1, Q2) demi-pont de l'étage secondaire suivant, les bornes de la charge (7) étant respectivement reliées au point milieu du premier demi-pont d'un premier étage secondaire, et au point milieu du second demi pont d'un dernier étage secondaire, et - un circuit de commande (15) adapté pour : ? sélectionner un groupe d'étages secondaires (20), dit étages actifs, et parmi lesdits étages actifs au moins un étage, dit étage de régulation, ? commander simultanément chaque étage actif, à l'exception de l'étage de régulation, à la fréquence des créneaux de courant, ? commander l'étage de régulation selon une fréquence supérieure à la précédente, avec un rapport cyclique de commande adapté pour réguler le courant circulant dans la charge à la valeur de consigne, ? commander les commutateurs (Q1-Q4) des étages secondaires non sélectionnés pour isoler leur source de tension.
Patent CA-2849822-A1 (CA)
Title: Novel influenza hemagglutinin protein-based vaccines
Inventor: NABEL GARY J M D
IPC: C07K19/00
Filed: 2012-09-24
Abstract: Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of ferritin joined to at least a portion of an influenza hemagglutinin protein. Some portions comprise the ectodomain while some portions are limited to the stem region. The fusion proteins self-assemble to form the hemagglutinin- displaying nanoparticles. Some vaccines comprise only the stem region of an influenza hemagglutinin protein joined to a trimerization domain. Such vaccines can be used to vaccinate an individual against infection by heterologous influenza viruses and influenza virus that are antigenically divergent from the virus from which the nanoparticle hemagglutinin protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
Patent CA-2850156-A1 (CA)
Inventor: FOLEY MARTIN P
IPC: A61F5/56
Filed: 2012-09-28
Abstract: La présente invention concerne un embout nasal comprenant un logement doté d'une paroi circonférentielle délimitant un passage intérieur. Ladite paroi comporte un espace longitudinal se prolongeant sur toute sa longueur, la dimension périphérique extérieure du logement pouvant être ajustée par modification dudit espace. Une valve est en communication avec le passage intérieur et limite l'écoulement d'un fluide à travers le passage intérieur dans au moins une direction. Dans un autre mode de réalisation, un embout nasal comprend une interface utilisateur comportant un logement tubulaire délimitant une cavité intérieure ouverte aux deux extrémités opposées. La surface extérieure du logement est conçue pour assurer l'interface avec les narines d'un utilisateur. Une base est présente dans la cavité intérieure du logement et comprend un orifice de sortie. Un bouchon est relié à la base et comporte un orifice d'entrée. Un élément de type valve est disposé dans un passage intérieur délimité par le bouchon et/ou la base, ledit élément de type valve étant amovible. L'invention concerne également des procédés d'utilisation et d'assemblage d'un tel embout nasal.
Patent CA-2850934-A1 (CA)
Inventor: ARMSTRONG STUART M
IPC: B63B27/00
Filed: 2011-08-09
Abstract: In an amphibious or flotational device for supporting one or more submersible pumps, the flotational device is structurally configured to provide the means for enabling both static and dynamic positioning of the submersible pumps at selected depths below the flotational device, and to provide means for improved pay-out and storage of flexible piping that enables improved dynamic positioning of the submersible pumps.
Patent CA-2854817-A1 (CA)
Inventor: MEDLMMUNE LIMITED
IPC: A61K39/395
Filed: 2012-11-06
Abstract: La présente invention concerne des polythérapies comprenant des molécules de liaison anti-Psl et PcrV de Pseudomonas et des compositions apparentées, destinées à être utilisées dans la prévention et le traitement d'une infection par Pseudomonas.
Patent CA-2862154-A1 (CA)
Title: Filter cleaning system and method
Inventor: HAMPTON JOHN
IPC: B01D24/46
Filed: 2013-02-04
Abstract: The present invention discloses a system and method for self-cleaning filters without having to open the filter housing. Wash nozzles are integrated with the filter housings such that when the filters are clogged, both back-wash and regular washing can be performed with practically no down time. Moreover, without opening the filter housing, the hazardous components of the fluid to be filtered can be contained and dealt with before they escape the filter housing, thereby significantly reduces the environmental impact and harm to the working crew.
Patent CA-2862181-A1 (CA)
Inventor: DAVIES LAURENCE
IPC: A47G1/20
Filed: 2014-09-08
Abstract: A frame which has a wire extending across a rear of the frame is hung on a wall by an integral flexible spring member shaped to define a center mounting plate fastened to lie flat on the wall and a spring strap standing at right angles to the plate with a pair of arms each extending outwardly from the mounting plate along the wall to a respective side of the mounting plate. The arms receive and locate the wire extending along the arms and depending from ends of the arms to the sides of the frame. The arms can flex and the arms allow longitudinal movement of the wire along the arms to allow movement of the frame side to side relative to the mounting plate. A stiffening rod can be inserted onto the strap.
Patent CA-2862993-A1 (CA)
Title: Urine markers for detection of bladder cancer
Inventor: GUILFORD PARRY JOHN
IPC: C12N1/34
Filed: 2005-07-22
Abstract: Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
Patent CA-2864936-A1 (CA)
Inventor: KLASSEN GERHARD DIETRICH
IPC: H04W84/18
Filed: 2014-09-24
Abstract: A near-field communication (NFC) capable mobile communication device (120) and a releaseable support (400) are described. The support can include one or more magnets (410) or other devices (610) disposed so as to releaseably engage the NFC-capable mobile communication device (120); and one or more persistent memorys (430) accessible by an NFC system (8130) of the NFC-capable mobile communication device (120), the persistent memory(ies) (430) comprising data suitable for causing the NFC-capable mobile communication device (120) to execute one or more wireless communication functions.
Patent CA-2868492-A1 (CA)
Inventor: NOVER CHRISTOPH
IPC: A24D1/02
Filed: 2014-10-21
Abstract: A tobacco product wrapping material comprising composite particles is described, the composite particles being obtainable my a method in which: (a) an aqueous suspension containing calcium carbonate particles is prepared; (b) a metal salt comprising an aluminum cation is added, wherein the metal salt (i) is able to form a basic metal component in the suspension and (ii) has a solubility of greater than 9.0 mg/L in water, measured at the pH value of the prepared suspension and at a temperature of 20°C, as well as a method for the production of same, the use of such tobacco product wrapping material for the production of tobacco products, and the tobacco products produced with them.
Patent CA-2870456-A1 (CA)
Inventor: MACDONALD GEORGE
IPC: F24F13/08
Filed: 2013-04-25
Abstract: A moisture and dust removing louver pack is composed of a set of pivotable louvers which can pivot between open and closed positions in an air passageway, the louvers allowing air to pass through the passageway when in the open position and having moisture and dust removing structure for air to impinge upon to remove moisture and dust from the air passing through the passageway.
Patent CA-2870599-A1 (CA)
Title: Agents for treating disorders involving modulation of ryanodine receptors
Inventor: YAN JIAMING
IPC: A61P19/08
Filed: 2013-04-17
Abstract: The present invention relates to 1,4-benzothiazepine derivatives of Formula (I) and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells (formula I) wherein R is COOH, or pharmaceutically acceptable salts thereof. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
Patent CA-2871539-A1 (CA)
Inventor: LUCAS RICHARD E
IPC: C10B41/00
Filed: 2013-05-09
Abstract: An automatic batch sequence computer control system is configured to automatically operate process valves in a delayed coker for a complete coke drum cycle. Double verification of the movement of the process valves is used to confirm advancing to the next step. Primary verification is achieved by using position sensors on the valves. Secondary verification is achieved by using monitored process conditions and confirming the measured conditions correlate with expected process conditions for an arrangement of valve positions at a given sequence in the coke drum cycle. A safety interlock system may be integrated with the control system.
Patent CA-2873190-A1 (CA)
Title: Ensemble de freins pour machine de coupe et de roulement automatisee
Inventor: MCISAAC FRANK
IPC: B21D5/04
Filed: 2014-12-02
Abstract: Une machine dassemblage de frein servant à former un ourlet dans une tôle comporte une barre de dessus et une barre de dessous opposée à la barre de dessus. La barre de dessus et la barre de dessous peuvent se déplacer lune vers lautre pour maintenir la tôle entre elles. La machine dassemblage de frein présente également un pied incliné déplaçable vers une proximité dune barre de courbure qui se déplace sur un axe de barre de courbure et comporte une face de courbure. Quand la barre de courbure se déplace sur laxe de la barre de courbure, la face de courbure de la barre de courbure peut se rapprocher du pied incliné et, avant que la face de courbure de la barre de courbure entre en contact avec le pied incliné, le pied incliné se déplace pour éviter le contact avec la barre de courbure.
Patent CA-2878442-A1 (CA)
Title: Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
Inventor: HERT JEROME
IPC: A61P1/16
Filed: 2013-09-23
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.