Patent AU-2018200647-A1 (AU)
Title: Methods for chronic pain management and treatment using hcg
Inventor: HICKS JR EDSON CONRAD
IPC: A61K38/24
Filed: 2018-01-29
Abstract: A gonadotropin is administered within a surprisingly effective narrow range for the purpose of treating chronic pain or other central sensitization sequelae. In one aspect, a recipient is provided with at least one of human chorionic gonadotropin (uHCG and/or rHCG), a pharmaceutically active HCG analogue, and a pharmaceutically active metabolite of the HCG or analogue at a dosage selected to provide, or be equivalent to, a human subcutaneous dosage of between 120 IU/day and 170 IU/day of HCG, and more preferably between 140 IU/day and 160 IU/day of HCG. A kit is also described, which includes a supply of the HCG-related drug, a delivery device, and a label that identifies chronic pain or central sensitization as an indication of the drug. See Fig. 1. WO 2012/142609 PCT/US2012/033828 Communicating with a person in a manner that aids in determining whether the person might suffer from chronic pain Wherein the step of communicating comprises obtaining medical and diagnostic data of at least one of (a) procuring from the person a written and an oral symptom history, and a physi cal examination; and at least one of (b) conducting and referring for testing procedures ---------------------------------------------------------- -~~~ ~ ~ ------------------------ ------------- Wherein the step of communicating is performed synchronously between a health care professional and the person ---------------------------------------------------------- -~ ----------------------------- ----------------------------- I Wherein the step of communicating is performed asynchronously between a health care professional and the person, using at least one of physical mail and electronic communication ---------------------------- ---------------------------- Facilitating the person discontinuously taking a drug at or equivalent to a subcutaneous dosage of Human Chorionic Gonadotropin (HCG) between 120 IU/day and 170 lU/day, inclu sivej with respect to chronic pain relief, for an express purpose of ameliorating the chronic pain wherein the drug is selected from the group consisting of at least one of HCG (uHCG or rHCG, a pharmaceutically active HCG analogue, and a pharmaceutically active metabolite of the HCG or analogue. ------~ ~ ~ ------------------------ II ------------- Wherein the step of facilitating comprises issuing a prescription for use of the drug by the person I--------------------------------------------------------------------------------------------- -------------------- --t----------------------- Wherein the step of facilitating comprises providing the person with contact information from which the person can procure a supply of the drug I-------------------------------------------------------------------------------------------- ---------------- It------------------------- Wherein the dosage is at or equivalent to a subcutaneous dosage of between 140 IU/day and 160 IU/day, inclusive, with respect to chronic pain relief ----------------------------------------------------- -- ~~~~ ~ ~-------- ----------------- II ------------- Further comprising conducting a testing procedure that aids in distinguishing between noci ceptive pain and central sensitization that the person may have I------------------------------------------------------------------------------------------ - - - -------------------------------------------------------- ----------------------------- Further comprising assisting in procuring for the person an adjunct to the drug that facilitates coupling to the Ga, i/o, G-Protein Coupled Receptor (GPCR) subunits, facilitating and/or enhancing an analgesic effect I--------------------------------------------------------------------------------------------- --------77----------- t ------------------------- Further comprising performing the step of facilitating after receiving information that HCG may have a peak effect on central sensitization between 120 IU/day and 170 IU/day, inclusive -----------------------------------------------------------