Patent SG-11201804858Y-A (SG)
Title: Crystalline forms of hydrochloride salts of thienopyrimidine compound
Inventor: BAEK JONG OUK
IPC: C07D403/10
Filed: 2016-12-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101110111101101111101011111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date .... ...,,, WO 2017/116192 Al 6 July 2017 (06.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: Y.P.LEE, MOCK & PARTNERS; 12F Daelim C07D 495/04 (2006.01) A61K 31/519 (2006.01) Acrotel, 13 Eonju-ro 30-gil, Gangnam-gu, Seoul 06292 CO7D 403/12 (2006.01) A61K 31/496 (2006.01) (KR). CO7D 403/10 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/KR2016/015535 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, 30 December 2016 (30.12.2016) HN, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 10-2015-0190853 TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 31 December 2015 (31.12.2015) KR ZA, ZM, ZW. 10-2016-0065977 27 May 2016 (27.05.2016) KR (84) Designated States (unless otherwise indicated, for every (71) Applicant: HANMI PHARM. CO ., LTD. [KR/KR]; 214, kind of regional protection available): ARIPO (BW, GH, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18536 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (KR). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: BAEK, Jong Ouk; 550, Dongtangiheung-ro, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — _ Hwaseong-si, Gyeonggi-do 18469 (KR). JEON, Ji Young; LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 550, Dongtangiheung-ro, Hwaseong-si, Gyeonggi-do SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 18469 (KR). OH, Hee Sook; 550, Dongtangiheung-ro, GW, KM, ML, MR, NE, SN, TD, TG). Hwaseong-si, Gyeonggi-do 18469 (KR). KIM, Hee Cheol; = 550, Dongtangiheung-ro, Hwaseong-si, Gyeonggi-do Published: = 18469 (KR). JANG, Sun Young; 550, Dongtangi- — with international search report (Art. 21(3)) = heung-ro, Hwaseong-si, Gyeonggi-do 18469 (KR). HA, Tae Hee; 550, Dongtangiheung-ro, Hwaseong-si, Gyeong- gi-do 18469 (KR). = = = = = = = (54) Title: CRYSTALLINE FORMS OF HYDROCHLORIDE SALTS OF THIENOPYRIMIDINE COMPOUND [Fig. 1A] = 4000 - g - i _ . 3000- _ - 0 1-1 >, g 2000 .4 f 1 N 1000 cT 1-1 ,tD 1-1 1-1 3 10 20 30 40 IN 2Theta (Degree) 1-1 (57) : The present invention relates to a crystalline form of a hydrochloride salt of N-(3-(2-(4-(4-methylpiperazin-1- 0 yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide, and a pharmaceutical composition containing the same. The \" crystalline form of the hydrochloride salt of the compound can be easily used for preparing a pharmaceutical composition containing 0 the same as an active ingredient.