Patent SG-11201903291T-A (SG)
Title: Methods and systems for assessing fertility based on subclinical genetic factors
Inventor: BEIM PIRAYE
IPC: G16B45/00
Filed: 2017-10-16
Abstract: IVFeSET GIFT ICSI ZIFT Treatment Independent f f Live Birth Total Fertilization Failure Low Ovarian Reserve On-Going Pregnancy Embryonic Development () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WI PO I PCT omit VIII °nolo mom otionoiliflo oimIE (10) International Publication Number WO 2018/071896 Al (51) International Patent Classification: GOOF 19/12 (2011.01) GOOF 19/26 (2011.01) GOOF 19/18 (2011.01) (21) International Application Number: PCT/US2017/056759 (22) International Filing Date: 16 October 2017 (16.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/408,632 14 October 2016 (14.10.2016) US 15/728,442 09 October 2017 (09.10.2017) US (71) Applicant: CELMATIX INC. [US/US]; 14 Wall St, Suite 16D, New York, NY 10005 (US). (72) Inventors: BEIM, Piraye, Yurttas; 1 Little West 12th Street, New York, NY 10014 (US). PARFITT, David, Em- lyn; 54 West 40th Street, New York, NY 10018 (US). HU- SELIGER, Tina; 14 Wall St., Suite 16D, New York, NY 10005 (US). SANTISTEVAN, Anthony; 3505 Broadway, Apartment 36, New York, NY 10031 (US). (74) Agent: MEYERS, Thomas, C. et al.; Brown Rudnick LLP, One Financial Center, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (54) Title: METHODS AND SYSTEMS FOR ASSESSING FERTILITY BASED ON SUBCLINICAL GENETIC FACTORS FIG. 8 Data Analytics Pipeline 0% 0. CLINICAL DATA Celmatix process begins CLINIC Quality Control Preprocess Standardize o 0 0 °. MODELS 0 110 I on M o OD in CLINICAL DATA GENOMIC DATA Logistic ANN Cox SVM Bayesian k-NN SKAT Rule-based OUTCOMES 1_ Number V usable cultured blastomeres on day 3 Number V usable cultured blastocysts V day 5 Clinical Pregnancy Biochemical Pregnancy Singleton Tw ns I > Twins (57) : The invention provides methods for generating a likelihood of achieving ongoing pregnancy in an individual by com- bining both clinical and genetic data. These methods involve the determination of one or more correlations between clinical character- istics and known pregnancy and infertility-related outcomes from a reference set of data to provide a model representative of a cumu- lative probability of ongoing pregnancy. The methods further involve the determination of one or more correlations between genetic characteristics and known pregnancy and infertility-related outcomes from the reference set of data to adjust the model. The model can then be applied to the input data to generate the likelihood of achieving ongoing pregnancy in the subject. [Continued on next page] WO 2018/071896 Al MIDEDIMOMOIDEIREEMONOMOHEIEROMMI (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))