Patent SG-11201811161Y-A (SG)
Title: Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
Inventor: CASIMIRO-GARCIA AGUSTIN
IPC: C07D471/08
Filed: 2017-07-07
Abstract: International Patent Classification: C07D 403/14 (2006.01) C07D 491/107 (2006.01) C07D 401/14 (2006.01) CO7D 498/10 (2006.01) CO7D 413/14 (2006.01) CO7D 498/18 (2006.01) CO7D 471/08 (2006.01) A61K 31/506 (2006.01) CO7D 487/04 (2006.01) A61P 29/00 (2006.01) CO7D 487/10 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 January 2018 (18.01.2018) WIPO I PCT omit °nolo omm HE mu im Imo oimIE (10) International Publication Number WO 2018/011681 Al PCT/IB2017/054104 (22) International Filing Date: 07 July 2017 (07.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/362,098 14 July 2016 (14.07.2016) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, New York 10017 (US). (72) Inventors: CASIMIRO-GARCIA, Agustin; 61 Wood- land Road, Concord, Massachusetts 01742 (US). STRO- HBACH, Joseph Walter; 114 Crockett Creek Drive, Wentzville, Missouri 63385 (US). HEPWORTH, David; 282 Sudbury Road, Concord, Massachusetts 01742 (US). LOVERING, Frank Eldridge; 2 Sutton Pl., Acton, Mass- achusetts 01720 (US). CHOI, Chulho; 56 Mariners Lane, Mystic, Connecticut 06355 (US). ALLAIS, Christophe Philippe; 64 Scotch Cap Road, Unit 114, Quaker Hill, Con- necticut 06375 (US). WRIGHT, Stephen Wayne; 1 Whit- man Lane, Old Lyme, Connecticut 06371 (US). (74) Agent: WALDRON, Roy F. et al.; PFIZER INC., 235 East 42nd Street, MS 235/9/S20, New York, New York 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) 1 -1 (54) Title: NOVEL PYRIMIDINE CARBOXAMIDES AS INHIBITORS OF VANIN-1 ENZYME GC 1-1 1-1 O C R ) 1° 0 3 R b Rib (JQ ) IR 1 NJ\"' \ N G xL N R Ra R2b R2a (I) (57) : Compounds, pharmaceutically acceptable salts thereof, are dis- closed wherein the compounds have the structure of (I) as defined in the spec- ification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.