Patent SG-11201909245P-A (SG)
Title: Methods and compositions for treating aging-associated impairments using ccr3-inhibitors
Inventor: BRAITHWAITE STEVEN P
IPC: C07D401/06
Filed: 2018-04-04
Abstract: WO 18/ 1875 03 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT (51) International Patent Classification: A61K 31/4545 (2006.01) C07D 401/06 (2006.01) (21) International Application Number: PCT/US2018/026131 (22) International Filing Date: Published: — with international search report (Art. 21(3)) 04 April 2018 (04.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,137 05 April 2017 (05.04.2017) US 62/560,940 20 September 2017 (20.09.2017) US 62/620,921 23 January 2018 (23.01.2018) US (71) Applicant: ALKAHEST, INC. [US/US]; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). (72) Inventors: BRAITHWAITE, Steven P.; 75 Shoreway Road, Suite D, San Carlos, California 94040 (US). MI- NAMI, S. Sakura; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). NIKOLICH, Karoly; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). (74) Agent: FIELD, Bret E.; 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS USING CCR3-INHIBI- TORS (57) : Methods of improving neurodegenerative disease with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount of the CCR3 modulating agent to the subject, with a concomitant improvement in cognition, motor, or other neurodegenerative-affected function. Cognitive and motor diseases upon which the methods of the invention can improve cognition include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, glaucoma, myotonic dystrophy, vascular dementia, progressive supranuclear palsy. omit IIl °nolo mo oimIE (10) International Publication Number WO 2018/187503 Al