Patent SG-11201806383T-A (SG)
Title: 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
Inventor: CHAPPIE THOMAS ALLEN
IPC: C07D519/00
Filed: 2017-02-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M1111101110101011111 HO 111110111010 11111 10011111011100111110111011# International Bureau (43) International Publication Date .......,./ (10) International Publication Number WO 2017/145013 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 498/04 (2006.01) A61K 31/5365 (2006.01) kind CO7D 519/00 (2006.01) A61P 25/00 (2006.01) AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/IB2017/050844 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 15 February 2017 (15.02.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/298,657 23 February 2016 (23.02.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, New York, New York 10017 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: CHAPPIE, Thomas Allen; 59 Hemlock Hill TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Road, Carlisle, Massachusetts 01741 (US). PATEL, DK, LV, Nandini Chaturbhai; 34 Mary Ellen Road, Waban, Mas- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, sachusetts 02468 (US). VERHOEST, Patrick Robert; 23 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Calvin Road, Newton, Massachusetts 02460 (US). GW, KM, ML, MR, NE, SN, TD, TG). HELAL, Christopher John; 18 Elm Street, Mystic, Con- Declarations under Rule 4.17: necticut 06355 (US). SCIABOLA, Simone; 109 River as to Street, Cambridge, Massachusetts 02139 (US). the identity of the inventor (Rule 4.170) LACHAPELLE, Erik Alphie; 69 Richard Brown Drive, — as to applicant's entitlement to apply for and be granted a Uncasville, Connecticut 06382 (US). WAGER, Travis T.; patent (Rule 4. 1700) 465 Washington Street, Apt. 6, Brookline, Massachusetts as to the applicant's entitlement to claim the priority of the 02446 (US). HAYWARD, Matthew Merrill; 3 Pyrus earlier application (Rule 4.17(iii)) Court, Old Lyme, Connecticut 06371 (US). Published: . (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). — with international search report (Art. 21(3)) Title: 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]0XAZINE-2-CARBOXAMIDE COMPOUNDS = (54) R 1 i 0 NO N N — R 2 en ,—, © ir) ii- / R3 ,-1 IN 1-1 (57) : The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, 0 wherein the substituents R', R 2 , R 3 , and R 'are as defined herein. The invention is also directed to pharmaceutical compositions com- \" prising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.