baber/WOPTO huggingface dataset:
Patent NZ-561342-A (NZ)
Title: Simultaneous quantification of nucleic acids in diseased cells
Inventor: STUYVER LIEVEN
IPC: C07H19/16
Filed: 2001-10-18
Abstract: Provided is a process for identifying a compound which inhibits viral replication, said process comprising: contacting nucleic acids, from a sample from a virus infected host that has been treated with the compound, with an amplification reaction mixture comprising a first and a second primer pair, probe, or primer pair and probe that provide detectable signals during a polymerase chain reaction, wherein the first primer pair, probe, or primer pair and probe provides a first detectable signal on the occurrence of the transcription of viral nucleic acids; and the second primer pair, probe, or primer pair and probe provides a second detectable signal on the occurrence of the transcription of host nucleic acids; said process further comprising normalizing the first detectable signal to the second detectable signal and comparing the normalized first detectable signal from a virus infected host that has been treated with the compound to a similarly normalized first detectable signal from a virus infected host that has not been treated with the compound, in order to assess the ability of the compound to inhibit viral replication.
Patent NZ-563568-A (NZ)
Title: Electromechanical lock device
Inventor: ANDERSSON DANIEL
IPC: E05B47/06
Filed: 2006-04-27
Abstract: Disclosed is a lock device which comprises of a housing (2) with an opening (4) and a core (10) rotatable in the opening. A latching element (20) co-acts between the housing and the core and can be moved between a release position in which the core is rotatable relative to the housing, and a latching position in which rotation of the core relative to the housing is blocked. An electronically controllable actuator (30) is disposed in the core and is moveable between an opening-registering-position in which the latching element is movable to the release position, and a latching position in which movement of the latching element to the release position is blocked. A returning means (50) co-acts mechanically with a key in a key way in the core and with the actuator and such as to move the actuator away from the position of the opening to a further latching position in response to the key being drawn out of the keyway. Movement of the latching element to the release position is blocked by the actuator in this further latching position.
Patent NZ-565243-A (NZ)
Title: Mask assembly
Inventor: BLOCHLINGER FRED
IPC: A61M16/06
Filed: 2006-08-21
Abstract: A nasal cushion 4 for a mask assembly for delivering pressurised gas to the nose of a subject, including a self-supporting side wall 38 defining a nose-receiving cavity, the side wall 38 extending from a first end to a second end and continuously tapered in thickness substantially from the first end to the second end, the side wall 38 formed continuously with a thin membrane 36 extending inwardly from a second end of the side wall 38 into the nose-receiving cavity for sealingly engaging the nose, upper lip and cheeks of the subject, and the first end adapted to engage a mask frame.
Patent NZ-566872-A (NZ)
Title: Pharmaceutical preparation having excellent photostability containing pitavastatin
Inventor: KOZAKI MASATO
IPC: A61K9/16
Filed: 2006-10-30
Abstract: Disclosed is a scored tablet including pitavastatin, a salt thereof, or an ester thereof, titanium oxide, and a colorant selected from food yellow no.4 and food yellow no.5 or a combination thereof. The tablet can be used in the treatment of hyperlipemia.
Patent NZ-570741-A (NZ)
Title: A method and device for automatic teat spraying
Inventor: GLOVER THOMAS
IPC: A01J7/04
Filed: 2008-08-22
Abstract: A teat washing system for a moving (rotary) milking platform 12 includes a teat spraying apparatus 4 mounted on a peripheral platform 1 and including a spray-head 5 that is extended over the milking platform to spray the teats of a cow standing in the platform bail and is then retracted from the platform. The spray-head is moved (along track 6) with the moving milking platform whilst the cows teats are being sprayed, and when retracted is moved to be in a position to be extended to spray the teats of the cow in the next bail.
Patent NZ-575193-A (NZ)
Title: Small molecule inhibitors of MDM2 comprising a spiropyrrolidine
Inventor: WANG SHAOMENG
IPC: C07D211/06
Filed: 2007-08-30
Abstract: Disclosed is a spiropyrrolidine compound of formula (I) where in the substituents are as disclosed in the description. Examples of compounds of formula (I) are: 6-chloro-4'-(3-chloro-4-fluorophenyl)-2'-(2,2-dimethyl-propyl)-5-fluoro-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5,carboxylic acid (2-ureido-ethyl)-amide; 6-chloro-4'-(3-chloro-4-fluorophenyl)-2'-(2,2-dimethyl-propyl)-5-fluoro-2-oxo-1,2-dihydro-spiro[indole-3,3'-purrolidine]-5'carboxylic acid (2,3,4-trihydroxy-butyl)-amide. Also disclosed is a pharmaceutical composition comprising a compound of formula(I) and the use of a compound of formula (I) in the manufacture of a medicament for inhibiting cell growth and/or division, inducing apoptosis and/or inducing cell cycle arrest in a cell; rendering a cell sensitive to additional agent(s) or treatment(s); treating, ameliorating, or preventing a disorder in an animal; inhibiting the interaction between p53 or p53-related proteins and MDM2 or MDM2-related proteins in a cell; inhibiting growth of a hyperproliferative cell containing functional p53 or p53-related proteins or the treatment, amelioration, or prevention of a disorder or condition caused by the administration of a chemotherapeutic agent or treatment. For example cancer. Further disclosed is a kit comprising a compound of formula (I).
Patent NZ-578110-A (NZ)
Title: Method for producing wood fibre composites which comprise wood fibres, and a combination of a thermoset resin and a thermoplastic resin
Inventor: WARNES JEREMY MARTIN
IPC: B27N3/00
Filed: 2010-06-30
Abstract: Disclosed are plastic-fibre composite products / pellets produced by a process which comprises: a) mechanically or thermomechanically or chemo-thermomechanically or chemo-mechanically breaking down a lignocellulosic material, or natural fibres to form loose or divided fibres or fibre bundles of a lignocellulosic material or natural fibres; b) applying to the product of a) a liquid or particulate binder formulation which comprises i) a thermoset resin (such as those which comprise urea formaldehyde or an isocyanate) and ii) an thermoplastic polymer (or monomer, or oligomer thereof) (such as polyethylene, polypropylene, polystyrene, polyvinyl alcohol, polyvinyl acetate, polyvinyl butyrate, polyester, polyacrylate, or starch based), wherein the thermoplastic polymer, monomer, or oligomer is present relative to the thermoset resin in a weight ratio up to about 50:50; and c) consolidating the product of b) into a solid product such as pellets or granules; wherein the plastic-fibre composite is useful as a feedstock in plastics manufacture, and particularly in the manufacture of composite fibre boards.
Patent NZ-587839-A (NZ)
Title: Creating left eye and right eye composite layers using a layer of a 2-D frame
Inventor: TURNER TARA HANDY
IPC: H04N13/00
Filed: 2010-09-07
Abstract: Disclosed is a method for generating a stereoscopic frame. The method comprises: obtaining one or more two dimensional frames of a two dimensional multimedia presentation, each two dimensional frame comprising one or more layers comprising a portion of the two dimensional frame; generating one or more left eye layers and one or more right eye layers for the one or more layers, wherein one or more of the left eye layers are horizontally offset from a respective one or more of the right eye layers; combining the one or more generated left eye layers into a composite left eye frame; and combining the one or more generated right eye layers into a composite right eye frame. The composite left eye frame and the composite right eye frame comprise a stereoscopic frame.
Patent NZ-592714-A (NZ)
Title: Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer
Inventor: MICHAELIDES MICHAEL R
IPC: A61K31/4155
Filed: 2009-12-04
Abstract: Disclosed herein are the compounds: N-(4-{ 4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N -(3-fluorophenyl)urea; N-(4-{ 4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N'-[4-(difluoromethoxy)phenyl]urea; N-[4-(4-amino-7-{ 1-[(2S)-2-hydroxypropyl]-1H-pyrazol-4-yl} thieno[3,2-c]pyridin-3-yl)phenyl]N'-(3-methylphenyl)urea; N-(4-{ 4-amino-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N'-(4-methoxyphenyl)urea; and N-[4-(4-amino-7-{ 1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-4-yl} thieno[3,2-c]pyridin-3-yl)phenyl]-N'-(4-methoxyphenyl)urea. Said compounds are useful as kinase inhibitors and as such is useful in the treatment of cancer.
Patent NZ-595647-A (NZ)
Title: Implant filling material and method
Inventor: BEISANG ARTHUR A
IPC: A61F2/12
Filed: 2010-05-04
Abstract: Abstract - 595647 Disclosed is an implant material (such as a breast implant) comprising a biocompatible, water-insoluble, hydrophilic, flexible, elastic, cohesive aqueous polyvinylpyrrolidone (PVP) gel mass having a water-stabilised volume made by a process comprising: (a) combining a volume of water with an amount of polyvinylpyrrolidone (PVP) having an average molecular weight-related viscosity of K 29/32 or greater and wherein the weight of PVP is at least 65% of the weight of the water, and a minor amount (such as from about 0.1% to 1% of the weight of the PVP) of a base (such as sodium hydroxide); (b) reacting the mixture at ambient temperature and pressure until a cohesive water-insoluble gel mass is formed; and (c) adding an amount of water to the reacted gel mass of (b) to maximize and stabilise the gel mass volume.
Patent NZ-596418-A (NZ)
Title: Rotationally locked cartridge connecting system
Inventor: NAYRAC FREDERIC
IPC: F16L37/244
Filed: 2006-04-25
Abstract: An assembly including a distribution member such as a solenoid valve 30 with an inlet fitting for the admission of gas into the combustion chamber of a hand operated gas powered fastening tool and a gas cartridge 20, also includes an adapter 2 to connect the distribution member and cartridge in operable communication. The adapter includes a locking structure 12 etc. for locking the cartridge against rotation relative to the tool and a guiding structure 15, 16 etc. for angularly guiding the cartridge toward a locked position in which the cartridge is locked against rotation relative to the tool. The adapter 2 is configured to connect the outlet fitting of the gas cartridge to the distribution member and to ensure sealing between the inlet and outlet fittings. The assembly includes an intermediate fitting 4 and the adapter 2 hooks flexibly on the intermediate fitting that is mounted on the distribution member.
Patent NZ-596494-A (NZ)
Title: Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
Inventor: FELBER BARBARA K
IPC: A61K38/17
Filed: 2007-01-12
Abstract: Patent No. 596494 Disclosed is an IL-15 receptor alpha (IL-15R alpha) polynucleotide encoding IL-15R alpha which can be used for expanding lymphocytes and cancer immunotherapy.
Patent NZ-598478-A (NZ)
Title: DIHYDROIMIDAZOQUINOLINE COMPOUNDS HAVING TAFIa INHIBITORY ACTIVITY
Inventor: AMADA HIDEAKI
IPC: A61P11/00
Filed: 2010-09-17
Abstract: The present disclosure provides compounds having superior TAFIa inhibitory activity. They are dihydroimidazoquinoline compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: (I) wherein R is a hydrogen atom or a C1-10 alkyl group; R1 is a hydrogen atom, a C1-10 alkyl group, a C3-8 cycloalkyl group or a substituent having the structure represented by the following formula Ia or Ib: (Ia) (Ib) where R3 is a C1-6 alkyl group; R4 is a C1-6 alkyl group, a C3-8 cycloalkyl group, or a benzyl group; and R2 is a hydrogen atom or a substituent having the structure represented by the following formula Ic or Id:(Ic) (Id)
Patent NZ-600253-A (NZ)
Title: A quick hitch coupler
Inventor: MCCORMICK CAROLINE
IPC: E02F3/96
Filed: 2010-11-02
Abstract: A quick hitch coupler (1) having an arrangement for releasably coupling a tool such as an excavator tool to the quick hitch coupler. The arrangement for releasably coupling the tool to the quick hitch coupler has tool pin engaging members (4) on spaced apart portions of the main body (213) of the quick hitch coupler. One of the tool pin engaging members has an associated latching member (7) movably mounted on the main body (213) of the quick hitch coupler between a tool pin locking position and a tool pin releasing position. The latching member has a locking means (9) movably mounted on the latching member for locking a tool pin onto the latching member quick hitch coupler in normal use. When the tool is in a fully crowded position, the locking means automatically disengages the tool pin prior to the latching means moving into a tool pin releasing position. This is advantageous in that operator intervention is not required to disengage the locking means. Safety of operation is also improved as the excavator must be in the crowded position to disengage the tool.
Patent NZ-601831-A (NZ)
Title: Docking station for patient bedside monitoring units
IPC: G16Z99/00
Filed: 2012-08-15
Abstract: Disclosed is a patient monitoring apparatus (400). The patient monitoring apparatus (400) comprises: (a) a processor; (b) a battery charging module in communication with the processor; (c) a storage device in communication with the processor; (d) a user interface (comprised of display 404 and input feature 406) in communication with the processor; and (e) a plurality of ports (402) in communication with the processor. Each port of the plurality ports (402) is configured to couple with a respective patient monitoring unit (40). The battery charging module is operable to charge patient monitoring units (40) through the plurality of ports (402). The storage device is operable to store data received from patient monitoring units (40) through the plurality of ports (402). The processor is operable to transmit updates to patient monitoring units (40) through the plurality of ports (402).
Patent NZ-602317-A (NZ)
Title: Stabilized alpha-galactosidase and uses thereof
Inventor: SHULMAN AVIDOR
IPC: C12N9/40
Filed: 2011-03-02
Abstract: NZ 602317 Disclosed is a multimeric protein structure comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety, wherein said linking moiety is not present in native alpha-galactosidase. The disclosed multimeric protein structure is used in the treatment of Fabry disease.
Patent NZ-602842-A (NZ)
Title: Method and devices for determining the distance between a radio beacon and a vehicle device
Inventor: SMELY DIETER
IPC: H04W4/02
Filed: 2011-11-29
Abstract: 602842 Disclosed is a method for determining the distance between a radio beacon (8) and an onboard unit (11) passing the beacon (8) in a road toll system (1). At least one of the two components, radio beacon (8) and onboard unit (11), emits a signal with a known curve of its frequency over time. The method includes receiving the signal in the other of the two components during passage and recording the curve of its frequency over time in relation to the known curve over time, and detecting a change in the recorded frequency curve exceeding a first threshold value. The method also includes looking for two far regions in the frequency curve lying before and after the detected change in time that show a frequency change below a second threshold value, and scaling the recorded frequency curve in such a manner that the far regions assume predetermined values. The distance is then determined from the scaled frequency curve. The signal is emitted intermittently and the frequency curve is processed in a time-discrete manner for time points at which the signal is received.
Patent NZ-602983-A (NZ)
Title: Botulinum toxin dosage regimen for chronic migraine prophylaxis
Inventor: AURORA SHEENA K
IPC: A61P21/02
Filed: 2011-03-29
Abstract: Disclosed is a use of a botulinum neurotoxin type A in the manufacture of a medicament for prophylactically treating a headache in a patient with chronic migraine headaches, the use essentially consisting of local administration of a botulinum neurotoxin to the frontalis, corrugator, procereus, occipitalis, temporalis, trapezius and cervical paraspinal muscles of the patient that suffers from the migraine headache; wherein the botulinum neurotoxin is administered: - to the frontalis at about twenty units divided among four sites of injection; - to the corrugator at about ten units divided among two sites of injection; - to the procerus at about five units to one site of injection; - to the occipitalis at about thirty units divided among six sites of injection to about forty units divided among eight sites of injection; - to the temporalis at about forty units divided among eight sites of injection up to fifty units divided among ten sites of injection; - to the trapezius at about thirty units divided among six sites of injection up to about fifty units divided among ten sites of injection; and - to the cervical paraspinal muscles at about twenty units divided among four sites of injection; wherein the botulinum neurotoxin is injected at 31 to 39 injection sites.
Patent NZ-603466-A (NZ)
Title: Dose counters for inhalers, inhalers and shafts thereof
Inventor: BUCK DAN
IPC: G06M1/24
Filed: 2011-05-18
Abstract: A dose counter for a metered dose inhaler indicates to a user the number of doses of active drug remaining in the medicament canister which is retained within and movable with respect to the body of the inhaler to dispense a dose. The dose counter includes an incremental counting system including a tape winder spool for a tape with incremental tape indicia for counting doses. The incremental counting system includes a main body and an actuator pawl 80 that is arranged to be driven in response to canister motion by the pin 34 and to increment a ratchet wheel 94 by engagement with the teeth of the ratchet. The actuator pawl 80 and ratchet wheel are configured to have predetermined canister fire (left hand figure) and count (right hand figure) configurations in a canister fire sequence. The canister fire configuration is determined by a position of the pawl relative to a datum at which the canister fires medicament. The count configuration is determined by a position of the pawl relative to the datum at which the incremental count system makes an incremental count. The ratchet wheel 94 has a plurality of circumferentially spaced teeth and an associated count pawl 138 (not to be confused with the actuation pawl 80). When in the count configuration, transitioning from the fire configuration, the count pawl 138 has finished riding up along a forward surface 142 of one of the teeth and has resiliently jumped over the tooth into engagement with the back of the next tooth to prevent backing of the count tape wound up on the spool rotated by rotation of the ratchet wheel.
Patent NZ-603613-A (NZ)
Title: Point-of-care fluidic systems and uses thereof
Inventor: HOLMES ELIZABETH A
IPC: A61B5/00
Filed: 2006-03-24
Abstract: A method of improving the accuracy of calibrating a fluidic system, comprising providing a system for detecting an analyte in a bodily fluid from a subject comprising a fluidic device for providing the bodily fluid, the fluidic device having a calibration assembly and a reader assembly for detecting the presence of the analyte, measuring one or more parameters that are fitted to a calibration curve associated with the fluidic device, comparing the one or more parameters with predetermined parameters associate with the fluidic device, and adjusting a signal output by the ratio of the predetermined parameters to the one or more parameters. The fluidic device also has a communication assembly for transmitting a detected signal from the reader assembly to an external device.
Patent NZ-603627-A (NZ)
Title: Method for producing 3-substituted-4-fluoropyrrolidine derivative
Inventor: SUZUKI MASASHI
IPC: C07D207/10
Filed: 2011-05-30
Abstract: 603627 Disclosed is a method for producing a compound represented by the general formula (8) such as (benzyl (3R,4R)-3-(N-cyclopropyl-aminomethyl)-4-hydroxypyrrolidine-1-carboxylate) or it’s enantiomer, or their salts, comprising step 1 and step 2: (Step 1) a process of fluorinating a compound represented by the general formula (6) (such as benzyl (3R,4R)-3-(N-cyclopropyl-N-(2-nitrobenzenesulfonyl)aminomethyl)-4-hydroxypyrrolidine-1-carboxylate) or it’s enantiomer using a nucleophilic fluorinating agent (such as nonafluorobutane-1-sulfonyl fluoride) and an organic base having an amidine or guanidine structure (such as tetramethylguanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, or 1,5-diazabicyclo[4.3.0]non-5-ene); and (Step 2) a process of deprotecting a protecting group on the amino group of the compound represented by the general formula (7) or it’s enantiomer, or their salts obtained in step 1 using a thiol compound and a base, and wherein PG1 represents a protecting group for an amino group, R1 represents an alkyl group which may be substituted or a cycloalkyl group which may be substituted, and Ns represents a 2-nitrobenzenesulfonyl group or a 4-nitrobenzenesulfonyl group.
Patent NZ-605709-A (NZ)
Title: Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
Inventor: JOHNSON BANKOLE A
IPC: G16B20/00
Filed: 2011-07-01
Abstract: 605709 Disclosed is the use of a composition, comprising: a therapeutically effective amount of ondansetron for the manufacture of a medicament for the treatment of an alcohol-related disease or disorder in a patient, wherein the patient’s HTR3A gene and optionally serotonin transporter gene SLC6A4 and/or HTR3B gene is known to have a genotype selected from: i. the AG genotype of rs1150226; ii. the AG genotype of rs1150226 and the AC genotype of rs17614942; iii. the AG genotype of rs1150226, the LL genotype of 5-HTTLPR, and the TT genotype of rs1042173; iv. the AG genotype of rs1150226, the AC genotype of rs17614942, the LL genotype of 5-HTTLPR, and the TT genotype of rs1042173; v. the AG genotype of rs1150226, the AC genotype of rs17614942, and the LL genotype of 5-HTTLPR; vi. the AG genotype of rs1150226 and the LL genotype of 5-HTTLPR.
Patent NZ-609825-A (NZ)
Title: Rescue descender system
Inventor: JONES OWAIN
IPC: A62B1/10
Filed: 2011-11-18
Abstract: A descent arresting system system for enabling a suspended body to be lowered is disclosed. The system comprises a rotatable descent line drum (24), a release element to prevent or allow the descent line to be deployed and a brake arrangement. The brake is arranged to apply a braking force to the rotatable descent line drum (24). The brake arrangement comprises a rotating brake (41) and a gear train (27, 29, 28) connecting the brake (41) to the drum (24). The gear train (27, 29, 28) is provided in a substantially watertight sealed space to prevent ice interfering with operation in cold temperatures.
Patent NZ-618511-A (NZ)
Title: A timber-working device and method of operation
Inventor: BRETT JAMES KAYE
IPC: B26D7/06
Filed: 2013-12-02
Abstract: Disclosed is a method for operating a timber-working device (4) that has a drive system and a cutting device (15). A controller receives an indication of one of at least two stems (40, 41) being processed by the timber-working device (4) having a damaged end. The drive system then feeds only the stem with the damaged end relative to the cutting device (15) by a predetermined distance.
Patent NZ-626513-A (NZ)
Title: Anti-cd98 antibodies and methods of use thereof
Inventor: LIPPINCOTT JOHN
IPC: C07K16/28
Filed: 2012-11-21
Abstract: The invention provides antibodies that bind CD98, and methods of use of the antibodies in the diagnosis and treatment of cancers.