Patent SG-11201809780W-A (SG)
Title: Filovirus consensus antigens, nucleic acid constructs and vacciens made therefrom, and methods of using same
Inventor: WEINER DAVID
IPC: A61P37/04
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property --11` . 1#1101111 0 11101 HOE 010 1111 1 0 I 11E1 OH MO 1110111111110 ill 011 1111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......\"' WO 2017/192947 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: NGUYEN, Quang, D. et al.; Riverside Law, LLP, A61K 35/76 (2015.01) A61P 31/14 (2006.01) Glenhardie Corporate Center, 1285 Drummers Lane, Suite A61K 39/12 (2006.01) A61P 37/04 (2006.01) 202, Wayne, PA 19087 (US). A61K 48/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/031215 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 05 May 2017 (05.05.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (26) Publication Language: English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (30) Priority Data: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 62/332,372 05 May 2016 (05.05.2016) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/402,519 30 September 2016 (30.09.2016) US (84) Designated States (unless otherwise indicated, for every 62/483,979 11 April 2017 (11.04.2017) US kind of regional protection available): ARIPO (BW, GH, (71) Applicant: WEINER, David [US/US]; 717 Beacom Lane, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Merion, PA 19066 (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors; and EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicants: PATEL, Ami [US/US]; 1 Rainey Court, — ou MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = Philadelphia, PA 19103 (US). YAN, Man [US/US]; 503 Sh- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, effield Drive, Wallingford, PA 19086 (US). KM, ML, MR, NE, SN, TD, TG). = (54) Title: FILOVIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCIENS MADE THEREFROM, AND METHODS OF USING SAME = = Q. Durba (05DRC99) '99 '07 Uganda (01Liga07) = '99 Durba (07DRC99) = Ozolin 75 Musoke '80 '67 Popp = E Leiden '08 = = '05 Angola R'jn Du 8 rba 7 1 (09ORC99) 99 _ ----t C = 0.005 Uganda (02ltga07) '07 = '96 Booun Mayibout '96 '94 Mekouka r'—' Bonifaee '76 Kikwit 95 '— Maleo '79 ZEf3OV CON VACCINE SLIDV CON VACCINE _ '76 Yambuku (Ekron) '--- Yambick '04 11 '00 Yambuku (Mayinga) 76 Gun] Kasai 'DS .. 0_005 ' Kasai '07 1.--' '05 Eteumbi '03 11' Mbomo/Mbandza 0.005 ei cT 1-1 ----- (57) : Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus ,-1 Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that 0 encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. \" Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus C: proteins are disclosed. [Continued on next page] WO 2017/192947 Al MIDEDIMOMMIDIRMEMOMOIHMENHOHMEMOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))