Patent SG-11201901633W-A (SG)
Title: 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
Inventor: GAO LU
IPC: C07D473/24
Filed: 2017-08-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIP0 I PCT omit VIII °nolo 010 0111011101111101 ow (10) International Publication Number WO 2018/041763 Al (51) International Patent Classification: CO7D 473/24 (2006.01) A61P 31/00 (2006.01) A61K 31/522 (2006.01) (21) International Application Number: PCT/EP2017/071514 (22) International Filing Date: 28 August 2017 (28.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2016/097140 29 August 2016 (29.08.2016) CN PCT/CN2017/092653 12 July 2017 (12.07.2017) CN (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). (72) Inventors: GAO, Lu; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). LIANG, Chungen; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). YUN, Hongy- ing; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). ZHENG, Xiufang; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). WANG, Jianping; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). MIAO, Kun; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). ZHANG, Bo; Building 5, No. 720, Cailun Road, Shanghai 201203 (CN). (74) Agent: BERNARD, Guillaume; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF It VIRUS INFECTION (57) : The present invention relates to compounds of formula (I), wherein R 1 , R and 2 N 0 NH 2 HN I 11 \":; z . / 0=S R 1 N R2 O 00 O C R 3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as TLR7 agonists for the treatment of viral infections. 0