baber/WOPTO huggingface dataset:
Patent DE-60334301-D1 (DE)
Inventor: MORRE MICHEL CHRISTIAN
IPC: A61K38/00
Filed: 2003-08-06
Granted: 2010-11-04
Abstract: The present invention relates, generally, to the fields of immunology and molecular biology. The invention discloses, more particularly, new and improved interleukin-7 drug substances, corresponding specific immunoreactive antibodies, as well as compositions comprising the same, their preparation and uses. The invention also discloses methods to characterize the impurity profile of a r-hlL-7 drug substance used for therapeutic purpose, as well as optimized nucleotide sequences encoding mammalian IL-7, recombinant expression vectors and methods for preparing and purifying said polypeptides. The present invention stems from the unexpected discovery that the long term activity of recombinant IL-7 is mostly expressed by a specific conformer and that other conformers, potential product-related substances, product-related impurities, and process-related impurities, which would normally be included in the specification of the drug substance and/or drug product, although bioactive, should be strictly minimized because they are able to trigger an immune reaction against the desired IL-7 molecule.
Patent DE-68901064-D1 (DE)
Inventor: SMITH VIVIENNE JEANETTE
IPC: B41M5/30
Filed: 1989-05-22
Granted: 1992-04-30
Abstract: Thermally sensitive record material (thermal paper) using 2,2-bis(4-hydroxyphenyl)-4-methylpentane as co-reactant with conventional electron donating chromogenic compounds and a combination of a long chain fatty acid amide was melting between 80 and 140 DEG C and a sensitizer melting between 60 and 120 DEG C and selected from diaryl ethers, acetoacetic anilides, phenyl hydroxynaphthoates, aryl or aralkyl substituted biphenyls and diaryl carbonates have high thermal sensitivity and good background whiteness.
Patent DE-68913525-D1 (DE)
Inventor: OKADA KATSUMI
IPC: A47J37/12
Filed: 1989-09-26
Granted: 1994-04-07
Abstract: An automatic food frying and vending system which is so constructed that a storage chamber (1A) for storing therein the food material to be fried in their frozen state and a frying chamber (1B) for frying the material in cooking oil are installed in the main body (1) of the automatic food frying and vending system in a discrete sections designated for their respective purposes; then a stocker (20) for receiving and keeping a large number of packed containers (P), each having lid or cover, of the abovementioned food material to be fried is provided in the abovementioned storage chamber (1A); a carrying means (40, 41) for taking out, one by one, from the storage chamber (1A) each container (P) of the food material to be fried which has so far been housed in the stocker (20), and transporting and feeding means (60) for receiving thereon the container (P) of the food material to be fried, as taken out of the storage chamber (20) by the carrying means (40, 41), opening the sealed cover of the container, and forwarding the food material to be fried into the frying chamber (1B).
Patent DE-68925454-D1 (DE)
Inventor: GOBLE NIGEL MARK
IPC: G01N33/50
Filed: 1989-10-10
Granted: 1996-02-29
Abstract: Apparatus for indicating a predisposition to kidney stone disease in humans, and also dehydration, and for monitoring the efficacy of hydration therapy, comprises a conductivity probe including a tip (11) which can be inserted into urine so that a drop thereof adheres to the tip, and display means for indicating the result as a derived function of conductivity (electrolyte concentration) in terms of urine specific gravity or osmolality. Preferably the probe electrodes (12, 13) are small and are spaced closely together so that the streamlines between the electrode tips are such that maximum current flows substantially within the adherent drop of urine.
Patent DE-68925610-D1 (DE)
Inventor: INGHAM MICHAEL
IPC: G03F7/32
Filed: 1989-10-16
Granted: 1996-03-21
Abstract: Image-wise exposed radiation sensitive compositions are processed using a developer liquid comprising an ethyl hexyl sulphate. The developer liquid may additionally include a surface active agent such as a polyoxyethylene lauryl ether or an ethylene oxide/propylene oxide condensate of poly(ethylene) glycol, an alkaline material such as sodium metasilicate, a water soluble carboxylic acid salt such as sodium octanoate, and the sodium salt of ethylene diamine tetra acetic acid. Such developer liquids can be formulated for use with either positive-working or negative-working plates.
Patent DE-68926881-D1 (DE)
Inventor: BLAIN STEPHEN
IPC: C08F2/44
Filed: 1989-02-09
Granted: 1996-08-29
Abstract: Polymerizable compositions comprising a liquid polymerizable continuous phase and a non-liquid, non-polymerizable dispersed discontinuous phase are stabilized against density drift of the discontinuous phase by forming in-situ, throughout and within said polymerizable composition a crystalline matrix of sufficient density to effectively inhibit density drift.
Patent DE-68927684-D1 (DE)
Inventor: EBBING PETER
IPC: G01B11/06
Filed: 1989-07-11
Granted: 1997-02-27
Abstract: The disclosure relates to a method for endpoint detection in a semiconductor wafer etching ysstem characterised in the steps of: 1) scanning a semiconductor wafer (10) with a narrowly focussed laser beam (24); 2) analyzing a reflected portion of the beam to determine a preferred parking spot (P) on a preferred flat area (#8) of the wafer; 3) parking the beams at the preferred spot; and 4) analyzing the reflected portion of the beam to determine when the preferred flat area has been etched through. The beam spot (18) of the laser beam (24) is amller than the width of the preferred flat area to eliminate noise generated at the transition boundaries of the flat area. Preferably, the wafer is scanned several times along the same beam path to permit the comparison of several scans to determine the preferred parking spot. The apparatus includes a beam forming assembled (62, 64, 66); a scanning assembly which causes the laser beam to scan across the wafer; a detection assembly (76) responsive to a portion of the laser beam which is reflected off the wafer; and a controller (78) which operates the laser and the scanning assembly and which is responsive to an output of the detection assembly. When output of the detection assembly indicates a cessation of the characteristic etching curve, the controller develops an endpoint detection signal which can automatically shut down the etching system. <IMAGE>   <IMAGE>
Patent DE-69006116-D1 (DE)
Inventor: VINCENT MICHEL
IPC: A61K38/00
Filed: 1990-06-29
Granted: 1994-03-03
Abstract: Derivatives of general formula (I): 
<IMAGE>
 in which: A denotes, with the carbon and nitrogen atoms to which it is bonded, a cycloamide group, B denotes, with the carbon and nitrogen atoms to which it is bonded, a saturated polycyclic structure, R denotes a hydrogen atom, a lower alkyl group or a 4-imidazolylmethyl group, substituted or otherwise, their diastereoisomers, enantiomers and epimers and their addition salts with a pharmaceutically acceptable acid. 
<??>Medications.
Patent DE-69012453-D1 (DE)
Inventor: VAN ZANTEN ALBERTUS
IPC: H01R4/24
Filed: 1990-06-05
Granted: 1994-10-20
Abstract: A contact element having a cutting section for insulation displacement connection of an insulated electrical conductor. The contact element being folded from a flat sheet of electrical conducting material, having a generally rectangular part which bears a lip projecting from one of its sides provided with a cutting slit in the end face and an angular piece having a part connected to said rectangular part and extending essentially parallel to said lip, and having a part which is at right angles thereto and faces away from said lip. The last mentioned part being provided with a further cutting slit in the end face. By appropriate folding of said flat sheet, a contact element being provided having a cutting section for side-piercing of an electrical conductor
Patent DE-69017480-D1 (DE)
Inventor: MIYAKE AKIO
IPC: C07D487/04
Filed: 1990-01-30
Granted: 1995-04-13
Abstract: The imidazo[1,2-b]pyridazine compounds of the formula: <CHEM> wherein R1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R2 and R3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R2 and R3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)n (n = 0 to 2), Alk is a straight or branched chain alkylene group containing 1 - 10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.
Patent DE-69020815-D1 (DE)
Inventor: SCHMALZ ALFRED CHANDLER
IPC: D06M101/16
Filed: 1990-05-26
Granted: 1995-08-17
Abstract: Disclosed is a method for treating polyolefin-containing spun fibers or filaments to increase their processability, in which the fibers or filaments are treated treated with a first modifier composition comprising from about 70% to 100% by weight of of a neutralized phosphoric acid ester having the formula    (Alk-O)n-@-O-Rm      (1) in which Alk is an lower alkyl group having 1-8 carbon atoms; R is an amino group or an alkali metal, n and m are each a positive number of not less than about 1, the sum of which is about 3; and from 0 to about 30% by weight of a polysiloxane having the formula <CHEM> wherein X and Y are individually defined as a hydrophobic chemical end group such as a lower alkyl group; R min  is a lower alkyl group, and o is a positive number within the range of about 10-50 or higher; and the fibers or filaments are subsequently treated with a second modifier composition comprising about 70%-100% by weight of the said polysiloxane and from 0 to about 30% by weight of the said neutralized phosphoric acid ester.
Patent DE-69021519-D1 (DE)
Inventor: MORMAN MICHAEL TOD
IPC: B32B5/04
Filed: 1990-12-12
Granted: 1995-09-14
Abstract: A composite elastic material is capable of stretching in at least two directions. The material has at least one elastic sheet and at least one necked material joined to the elastic sheet at least at three locations arranged in a nonlinear configuration, so that the necked web is gathered between at least two of those locations. Also disclosed is a method of producing a composite elastic material capable of stretching in at least two directions. <IMAGE>
Patent DE-69030326-D1 (DE)
Inventor: ROSENBERG EUGENE
IPC: D21C9/10
Filed: 1990-12-28
Granted: 1997-04-30
Abstract: The invention relates to a preparation exhibiting enzymatic activity, which preparation has the capability of delignifying wood pulp at a temperature of at least 65 DEG  C. and a pH of at least 9. Further, the invention relates to a method of producing said preparation by aerobically fermentating a selected Bacillus stearothermophilus strain. Furthermore, the invention relates to two isolated Bacillus stearothermophilus strains and mutants and variants thereof. The invention also relates to applications of the preparation of the invention, namely to a process comprising treatment of wood pulp with a preparation according to the invention, and a wood pulp and a fluff pulp treated with a preparation according to the invention, and also a paper, a board and a fluff made from a wood pulp treated with a preparation according to the invention.
Patent DE-69030888-D1 (DE)
Inventor: WIRTH LAWRENCE W
IPC: B31B19/90
Filed: 1990-04-24
Granted: 1997-07-10
Abstract: The disclosure relates to a method of forming a recloseable package (10) using special profile strips (20, 30); the strips themselves and a resulting package are disclosed. The profile strips have a flange element (22, 32) and a recloseable means element (24, 34), and two mated profile strips are provided with a heat barrier means (23, 33).   The method comprises the steps of providing mated top and bottom profile strips (20, 30) providing top and bottom package films (12, 14) on opposite sides of the mated strips and applying heat and pressure to the films adjacent the flanges (22, 32) sufficient to simultaneously form heat seals respectively between the top film (12) and the top profile strip flange (22) and between the bottom film (14) and bottom profile strip flange (32). The heat barrier means may comprise a thickened flange element (23, 33) buffer strip or a coextrusion of high temperature resin on the inside layer of the flange element. The heat barrier means prevents the flanges from fusing together during the formation of flange-film seals. <IMAGE>   <IMAGE>
Patent DE-69104992-D1 (DE)
Inventor: ROSE RICHARD
IPC: C09D125/02
Filed: 1991-08-21
Granted: 1994-12-08
Abstract: Improved flame retardant latex coatings are disclosed which comprise copolymers of ring-halogenated aromatic monomer units and alkyl acrylate/methacrylate monomer units, and which may additionally include at least one other monomer. In a first embodiment, the coatings include ring-brominated aromatic monomer units and alkyl acrylate and/or alkyl methacrylate monomer units. In a second embodiment, the coatings include these first two types of monomer units and further include third monomer units from unsaturated esters of saturated carboxylic acids, halogen-free aromatic monomers or unsaturated carboxylic or dicarboxylic acid monomers. In a third embodiment, the coatings include four monomer units, namely ring-brominated aromatic monomer units, alkyl acrylate/methacrylate monomer units, halogen-free aromatic monomer units and unsaturated carboxylic or dicarboxylic acid monomer units. In one aspect, the halogenated aromatic monomers are present in an amount to provide from 7 to 20 weight percent bromine in the final latex coating. In another aspect, the halogenated aromatic monomers include polybrominated monomers, particularly to provide monomers having an average of at least about 1.5 bromines per monomer unit. The coating polymers have glass transition temperatures in the -30 degrees C. to 30 degrees C. range and are useful, for example, for coating, paint, adhesive, sealant and non-woven binder applications.
Patent DE-69109677-D1 (DE)
Inventor: KAVANAGH DEAN
IPC: B32B27/36
Filed: 1991-05-23
Granted: 1995-06-14
Abstract: A flexible, draw-formed laminate for a safety glazing comprising a transparent, thermoplastic carrier film which is shrink-stable during laminating formation of such safety glazing bonded to at least one layer of plasticized polyvinyl butyral, such film having a greater tensile modulus than that of the layer of plasticized polyvinyl butyral. The carrier film is preferably flexible polyester such as polyethylene terephthalate having one or more functional performance coatings or layers on its surface such as a multi-layered solar radiation control stack.
Patent DE-69109897-D1 (DE)
Inventor: HARDIN PAUL W
IPC: E01F15/00
Filed: 1991-03-01
Granted: 1995-06-29
Abstract: The disclosure relates to a traffic barrier gate (15) for controlling the flow of vehicles through a barrier, such as a concrete median wall between opposing traffic lanes of a controlled access highway. In one embodiment the gate comprises hinged sidewall panels (21a, 21b) connected to a support member (26) which is moved vertically on command and which, when moved, causes the sidewall panels to collapse and spread out thereby forming a ramp for the passage of vehicles through the wall barrier. In a second embodiment, the gate (15) revolves 180 DEG , upon command, and then retracts into a well (66) in the ground thereby forming the traffic ramp. <IMAGE>   <IMAGE>
Patent DE-69111214-D1 (DE)
Inventor: MAGNONI FRANCO
IPC: B21H1/04
Filed: 1991-12-09
Granted: 1995-08-17
Abstract: The invention finds application in the field of cutting tools, in particular for the cutting of disc-shaped metal sheets. More precisely, the invention relates to a disc-shaped tool (1) equipped with a knife with a circular cutting edge (4), having laterally two curved flanks (3). The knife (4) inserts itself into the width of a disc-shaped metal sheet (2), partially separating it into two sheets (5). <IMAGE>
Patent DE-69113926-D1 (DE)
Inventor: BERTA DOMINIC A
IPC: C08L23/00
Filed: 1991-08-06
Granted: 1995-11-23
Abstract: Disclosed is a dynamically partially crosslinked thermoplastic elastomer comprising a propylene polymer material, an amorphous ethylene-propylene copolymer rubber, a semi-crystalline, low density, essentially linear ethylene-propylene copolymer and a polybutene-1 polymer.
Patent DE-69117101-D1 (DE)
Inventor: LEONARD ANDRE
IPC: B62D57/024
Filed: 1991-06-07
Granted: 1996-03-28
Abstract: This vehicle is composed of a mechanism for the simultaneous rotation of pistons 10 arranged in telescopic stars capable of adapting to the differing shapes of the cavities through which it travels. At the extremities of these pistons, wheels or tracks 54, activated by independent motors, are used to propel and move the vehicle. A joint 9 allows the vehicle to bend so as to enable it to change direction in tight spaces. A cable drum 6 allows a cable 4 to be paid out as the vehicle advances to a great distance, and this cable transmits power and the data from a mobile video camera 15. 
<??>Of particular application to the inspection of urban and industrial grids over long distances. 
<IMAGE>
Patent DE-69129475-D1 (DE)
Inventor: SPERK JAMES M
IPC: C08L/
Filed: 1991-03-06
Granted: 1998-07-02
Abstract: Thermoplastic molding compositions and articles comprise immiscible thermoplastic polymer components and reinforcing fibers. The immiscible thermoplastic polymer components and the fibers are blended together under high shear conditions. The molding composition generally contains at least two phases and has an extremely smooth and fiber-free surface. Generally, very good physical properties are obtained such as high impact resistance, high heat distortion temperatures, high tensile modulus, high flex modulus, and the like. A desired blend of thermoplastic components is thermoplastic polyurethane and polyethyleneterephthalate with glass fibers.
Patent DE-69130048-D1 (DE)
Inventor: HOUGHTON RICHARD DAVID
IPC: A01N25/14
Filed: 1991-10-30
Granted: 1998-10-01
Abstract: A dispersable granular formulation has been developed which contains at least 60% propanil herbicide. This formulation also provides excellent suspensibility and dispersibility characteristics and resists attrition.
Patent DE-69130586-D1 (DE)
Inventor: UENO RYUJI
IPC: A61K31/557
Filed: 1991-04-29
Granted: 1999-01-21
Abstract: A use of a 15-ketoprostaglandin compound for the manufacture of a medicament for treatment of a pancreatic disease.
Patent DE-69131482-D1 (DE)
Title: Phosphotyrosin phosphatase als neuer rezeptor-typ
Inventor: SCHLESSINGER JOSEPH
IPC: G01N33/53
Filed: 1991-07-11
Granted: 1999-09-02
Abstract: A novel receptor-type protein tyrosine phosphatase protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human R-PTPase- alpha , human R-PTPase- beta  and human R-PTPase-gamma. The R-PTPase protein or glycoproteins may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
Patent DE-69205668-D1 (DE)
Inventor: PARATTE DANIEL
IPC: G04C10/00
Filed: 1992-11-20
Granted: 1995-11-30
Abstract: The container (2) for a replacement battery (12) for a watch includes, apart from a housing to contain this battery, means (15) of access to the watch battery which is to be changed. Incidentally, the container can serve as a key-holder, offering the advantage of always being carried by the person wearing the watch. The container is in two parts: a case (17) in which there is a slide (18), this slide carrying the exchange battery (12) and an incorporated tool (15) which enables the spent battery to be extracted from the watch. <IMAGE>
Patent DE-69207030-D1 (DE)
Inventor: HAMABURA KIMIO
IPC: C07B61/00
Filed: 1992-03-12
Granted: 1996-02-08
Abstract: To provide novel terpenes which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof. In reacting a compound represented by the general formula (II): <CHEM>     wherein n is 0 or 1 or 2,  with a compound represented by the general formula (III): <CHEM> wherein R<1> represents a lower alkyl group; and R<2> represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group, to form a terpene derivative represented by the general formula (I):   <CHEM> wherein R<1> represents a lower alkyl group; R<2> represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol <IMAGE> represents a single or double bond with the proviso that both of the linkages adjacent to each other must not be simultaneously single bonds or double bonds, the above reaction is conducted in an organic solvent in the presence of a transition metal compound and an organic amine.
Patent DE-69214652-D1 (DE)
Inventor: CONSTANTINIDES PANAYIOTIS PERI
IPC: A61K38/095
Filed: 1992-07-24
Granted: 1996-11-21
Abstract: Pharmaceutically acceptable, stable, self-emulsifying (w/o) microemulsions comprising (i) a lipophilic phase comprising a medium-chain fatty acid triglyceride and a low HLB surfactant, (ii) an aqueous-based hydrophilic phase containing a water-soluble therapeutic agent, and (iii) a high HLB surfactant have improved drug-delivery characteristics.
Patent DE-69214934-D1 (DE)
Inventor: MARTIN JIMENEZ JOSE L
IPC: C07C237/46
Filed: 1992-11-17
Granted: 1996-12-05
Abstract: The invention discloses new non ionic iodized agents for X-ray contrasting, having a dimer structure and a general formula (I) wherein the union bridge is glycin or glycin N-substituted, wherein R1 is a straight or branched polyhydroxyalkyl residue with 2 to 4 carbon atoms, R2 is hydrogen, methyl or a straight polyhydroxyalkyl residue with 2 or 3 carbon atoms, R3 and R8, similar or different, are hydrogen, methyl or 2-hydroxy ethyl, R4 is a straight or branched polyhydroxyalkyl residue with 2 to 4 carbon atoms, R5 is methyl, hydroxymethyl or metoxymethyl, and R6 and R7, similar or different are hydrogen, methyl, 2-hydroxyethyl or 2,3-dihydroxypropyl, R2 and R5 may form together a group of the type (a) wherein n is from 0 to 3. The invention also discloses methods for obtaining products of formula (I) and pharmaceutically acceptable preparations which contain said products.
Patent DE-69216482-D1 (DE)
Inventor: KATAKURA KAZUNORI
IPC: G02F1/133
Filed: 1992-06-17
Granted: 1997-02-20
Abstract: A display apparatus includes a matrix of electrodes formed of scanning electrodes and information electrodes. A scanning device uses a plurality of scanning methods for selecting scanning electrodes and performs the scanning methods according to respective priorities, and a driving device changes driving conditions according to the scanning methods or the priorities thereof. <IMAGE>
Patent DE-69218162-D1 (DE)
Inventor: DUNEAU ANDRE
IPC: F21V5/00
Filed: 1992-12-17
Granted: 1997-04-17
Abstract: The invention relates to a lens (G) for at least one signalling light, in particular for a motor vehicle, comprising a plurality of pseudo-catadioptric elements, having the appearance of catadioptric needles without acting as such. At least some of the pseudo-catadioptric elements (20) have a conical end (26) on the inner side of the lens. The making of a mould for bulk manufacturing of such a lens is thereby greatly facilitated. <IMAGE>