Patent SG-11201803903Y-A (SG)
Title: Combination therapy for cancer
Inventor: BECKMANN RICHARD PAUL
IPC: A61P35/00
Filed: 2016-12-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) (43) International Publication Date .... ..sr.) 22 June 2017(22.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International EOM DENIM 2017/105982 Publication Al Number IIIII D In (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/4745 (2006.01) A61P 35/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 31/497 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KB, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2016/065503 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 8 December 2016 (08.12.2016) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/267,462 15 December 2015 (15.12.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: ELI LILLY AND COMPANY [US/US]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Lilly Corporate Center, Indianapolis, Indiana 46285 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: BECKMANN, Richard Paul; do Eli Lilly and LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Company, P.O. Box 6288, Indianapolis, Indiana 46206- GW, KM, ML, MR, NE, SN, TD, TG). 6288 (US). DONOHO, Gregory Paul; c/o Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indiana 46206- Declarations under Rule 4.17: 6288 (US). LIN, Aimee Karis; c/o Eli Lilly and Company, as to applicant's entitlement to apply for and be granted a P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). patent (Rule 4.17 (ii)) c/o and WACHECK, Volker; Eli Lilly Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) (74) Agents: DINGESS-HAMMOND, Elizabeth et al.; Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indiana Published: 46206-6288 (US). — with international search report (Art 21(3)) Designated States indicated, (81) (unless otherwise for every kind of national available): AE, AG, AL, AM, protection (54) Title: COMBINATION THERAPY FOR CANCER N z N-N Il .4t N GC Cr\ In 0 11 IN 1-1 (57) : The present invention O der cancer, cervical cancer, endometrial N tient in need of such treatment 0 combination with an effective amount OH an effective of provides cancer, 1401 amount a compound a method of treating squamous histology cancers, breast cancer, prostate cancer, blad- ovarian 1 • N H (I I) N (I) cancer, and colorectal cancer in a patient comprising administering to a pa - of a compound of the foimula (I) or a pharmaceutically acceptable salt thereof; in of the foiinula (II)or a phaiinaceutically acceptable salt thereof