Patent IL-117349-A (IL)
Title: N-(3-benzofuranyl) urea derivatives, their preparation and pharmaceutical compositions containing them
IPC: C07D405/12
Filed: 1996-03-04
Abstract: Anti-inflammatory compounds of the formula 2666 ו' בתשרי התשס" ג - September 12, 2002 in which A and D are identical or different and represent hydrogen, straight-chain or branched acyl or alkoxycarbonyl, each having up to 6 carbon atoms, or straight- chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by carboxyl or alkoxycarbonyl having up to 6 carbon atoms, phenoxy or benzoyl, or represent halogen, carboxyl, cyano, nitro, trifluromethyl, trifluoromethoxy or a group of a formula -OR5, -S(O)aR6, -(O-CH2-CO)b-NR7R8, -CO-NR9R10, -SO2-NR11R12 or-NH- SO2-NR11R12 or -NH-SO2R13, in which R5, R6, R8, R9, R10, R11 and R12 are identical or different and denote hydrogen, cycloalkyl having 3 to 6 carbon atoms, benzyl or a 5 to 7-membered saturated or unsaturated heterocycle having up to 3 heteroatoms from the series comprising N, S and O and to which a phenyl ring can be fused and which is optionally substituted by identical or different subsitutents from the series comprising halogen, cyano, nitro or by a straight-chain or branched alkyl having up to 6 carbon atoms or denote straight-chain or branched alkyl, alkenyl or acyl each having up to 8 carbon atoms, or denote phenyl, which is optionally monosubstituted to disubstituted by identical or different substituents from the series comprising nitro, halogen, carboxy or straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or R5 denotes a hydroxyl protecting gorup or straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is substituted by carboxyl, hydroxyl, straight-chain or branched acyl or alkoxycarbonyl each having up to 6 2667 ו' בתשרי התשס" ג - September 12, 2002 carbon actoms, phenoxyl, benzoyl or by a 5 to 7-membered unsaturated heterocycle having up to 3 hetero atoms from the series comprising N, S and/or O, which is optionally substituted by halogen, cyano, nitro or by straight-chain or branched alkyl haivng up to 6 carbon atoms or R5 denotes a group of a formula SO2R14, in which R14 denotes phenyl, trifluoromethyl or straight-chain or branched alkyl having up to 4 carbon atoms, a denotes a number 0, 1 or 2, b denotes a number 0 or 1, R7 denotes hydrogen or a straight-chain or branched alkyl having up to 4 carbon atoms, R13 denotes aryl having up to 6 to 10 carbon atoms, trifluoromethyl or straight- chain or branched alkyl having up to 6 carbon atoms, R1 represents hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, an aminoprotecting group or a group of the formula -CO-R15, in which R15 denotes hydroxyl, straight chain or branched alkoxycarbonyl having up to 6 carbon atoms, cycloalkyl having up to 3 to 6 carbon atoms, pyridyl, pyrrolidinyl or straight chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by halogen, carboxyl or straight chain or branched alkoxycarbonyl having up to 6 carbon atoms, or denotes phenyl, which is optionally subsituted by hydroxyl, carboxyl or straight chain or branched alkoxy or alkoxycarbonyl each having up to 6 carbon atoms, L represents an oxygen or sulfur atom, R2 and R3 are identical or different and represent hydrogen, cycloalkyl having up to 6 carbon atoms, straight chain or branched alkyl, alkoxycarbonyl or alkenyl each having up to 8 carbon atoms, or represent benzoyl or aryl having 6 to 10 carbon atoms, which are optionally monosubstituted to trisubstituted by identical or different substituents from the series comprising halogen, cyano, nitro, carboxyl, straight-chain or branched alkyl, alkoxy, alkoxycarbonyl or acyl each having up to 6 carbon atoms, or R2 and R3 together with the nitrogen atom form a 5- to 7-membered saturated heterocycle optionally having a further O atom, and R4 represents phenyl, which is optionally monosubstituted to trisubstituted by identical or different substituents from the series comprising hydr