baber/WOPTO huggingface dataset:
Patent TW-I790814-B (TW)
Title: 環保水溶性金還原劑與提煉金的處理方法
Inventor: YANG CHUNG-SUNG
IPC: C22B11/00
Filed: 2021-11-10
Granted: 2023-01-21
Abstract: 一種水溶性的金還原劑，包含：氯化鈉(7wt%-10wt%)、硫酸(4wt%-6wt%)、 草酸(4wt%-15wt%)、亞硫酸(1.5wt%-6wt%)、亞硫酸鈉(2.5wt%-18wt%)、以及餘量的水。一種從原礦砂中提煉金的處理方法，包含一組金氧化的步驟、以及一組金還原的步驟，該組金還原步驟乃是透過上述水溶性的金還原劑進行操作。此種水溶性的金還原劑可在酸性或弱鹼性條件下進行金還原的反應，能使水溶液中剝離出的金離子的還原反應，得到完全的進行。
Patent TW-I803052-B (TW)
Inventor: CHEN YU SHUAN
IPC: A61K9/00
Filed: 2021-11-12
Granted: 2023-05-21
Abstract: 本揭露提供一種藥物之經皮遞送裝置。該裝置包含可分離之基底，並裝載有基於互穿聚合物網狀水凝膠之雙重藥物。本揭露亦提供製造和使用該經皮遞送裝置之方法。
Patent TW-I790036-B (TW)
Inventor: HUNG TSUNG-YI
IPC: H01L21/68
Filed: 2021-12-10
Granted: 2023-01-11
Abstract: An electronic device includes a via-array substrate, an outer layer, and an alignment substrate. The via-array substrate has a plurality of first vias. The outer layer has a plurality of second vias and is disposed on a side of the via-array substrate. The first vias have a larger distribution density or quantity than the second vias. A part of the first vias is electrically connected to the second vias, and another part of the first vias is electrically floating. The alignment substrate includes a core layer disposed on the outer layer, a plurality of conductive traces, a plurality of interconnecting pads, and a plurality of alignment mark pads. The conductive traces are disposed in the core layer. The interconnecting pads and the alignment mark pads are disposed on a surface of the core layer located away from the outer layer. A part of the conductive traces electrically connects a part of the inner connection pads and a part of the first vias. Each of alignment mark pads has a pattern different from each of the interconnecting pads.
Patent TW-I771247-B (TW)
Title: 具有核心a餡料、中間層b餡料及外層c麵團的包心麵條、用於其之押出成形的模具及方法
Inventor: CHEN QING-RONG
IPC: A21C9/00
Filed: 2021-12-15
Granted: 2022-07-11
Abstract: 本發明揭示一種具有核心A餡料、中間層B餡料及外層C麵團的包心麵條，其中作為該核心A餡料的食材相對的具有較低的黏稠度，作為該中間層B餡料的食材相對的具有較高的黏稠度，該外層C麵團在三者中則具有最高的黏稠度，其中該中間層B餡料提供了該外層C麵團與該核心A餡料之間的一個過渡，而可以使得該中間層B餡料與該核心A餡料之間、及該外層C麵團與該中間層B餡料之間附著良好，於是可被押出成形該包心麵條。本發明亦揭示用於該包心麵條的押出成形的模具及方法。
Patent TW-I787017-B (TW)
Title: 醫療個案管理系統
Inventor: Lan shu-zhen
IPC: G16H50/20
Filed: 2021-12-24
Granted: 2022-12-11
Abstract: 本發明係揭露一種醫療個案管理系統，用以整合醫療資訊系統(HIS)以及連結至健保資訊網服務系統(VPN)。本發明是將收案患者進行問診與選取醫療方案及其相對應的醫療品質資訊，據以生成臨床路徑資訊與醫囑資訊；再根據臨床路徑資訊對患者進行後續的照護追蹤與管理，並生成照護資訊。資料處理模組用以整合臨床路徑資訊、醫囑資訊與照護資訊，並生成個案診療資訊。本發明能夠提供醫生根據個案診療資訊而快速診療，並更新或設定臨床路徑資訊、醫囑資訊，以有效縮短診療時間，並將患者與醫療方案對應串接並統計分析，有助於醫生作出更精確的醫療決策。
Patent TW-I811943-B (TW)
Title: Auxiliary system of interchanging container for customs clearance and auxiliary method
Inventor: Chen kai sheng
IPC: G07C9/22
Filed: 2022-01-05
Granted: 2023-08-11
Abstract: This present invention is an auxiliary system of interchanging container for customs clearance and an auxiliary method including a management server, a container yard module and a communication device. After the management server is used for users to create the container interchange data, the container interchange data is pre-reviewed by the container yard module. The management server then forms the equipment despatch order data according to the pre-review results. After that, the container truck driver only needs to receive the equipment despatch order data through the communication device carried, and then the container truck driver can carry out the customs clearance, pick up the container and leave the container yard. During the process of going out, there is no need to get off the truck frequently to perform various manual operations, so as to solve the time-consuming and efficiency problems of the conventional technology.
Patent TW-I796150-B (TW)
Title: Luminous roller structure
Inventor: Tang xue-feng
IPC: G06F3/0362
Filed: 2022-03-01
Granted: 2023-03-11
Abstract: The present invention discloses a luminous roller structure including a roller, a support frame and a light source module. The support frame is used to support the rollers and includes a first support part and a second support part opposite to each other, and the roller is located between the first support part and the second support part. The first support portion has at least one through hole. The through hole includes a first side wall section and a second side wall section , the second side wall section is located between the first side wall section and the roller, the first side wall section defines a first opening, and the second side wall section is gradually inclined toward the direction of the roller to define a second opening opposite to the first opening, the diameter of the second opening is larger than the diameter of the first opening. The light source module includes a circuit board and at least one light-emitting element disposed on the circuit board. The circuit board is disposed on the first support part, so that the light-emitting element corresponds to the through hole.
Patent TW-I806522-B (TW)
Title: 玻璃基板製造裝置及管構件
Inventor: LIN CHIHYANG
IPC: C03B17/06
Filed: 2022-03-28
Granted: 2023-06-21
Abstract: 本發明提供一種可抑制形成於管構件且具有徑向之凹凸的波形狀部中之局部應力集中的玻璃基板製造裝置。
        玻璃基板製造裝置具備：管構件，其由包含鉑族金屬之材料組成，且具有於軸向延伸之周狀之壁部。壁部於軸向之一部分區域，包含：至少1個波形狀部，其以於軸向交替排列且於周向連續之方式形成，具有壁部之徑向之凹凸。波形狀部中朝徑向凸出之凸部具有凸出高度為最高之第1凸部、與相對於第1凸部配置於軸向之兩側，且凸出高度較第1凸部更低之一對第2凸部。波形狀部中朝徑向凹陷之凹部具有位於第1凸部與第2凸部之間之一對第1凹部。於沿著朝軸向及徑向延伸之平面的壁部之剖面中，第1凹部各者之長度較第1凸部之長度為長。
Patent TW-I816469-B (TW)
Title: 船務通訊系統、方法、傳輸裝置及岸際計算中心
Inventor: Chen jun-quan
IPC: H04W4/44
Filed: 2022-07-15
Granted: 2023-09-21
Abstract: 一種船務通訊系統，其包括岸際計算中心與至少一船艦。岸際計算中心係位於岸際。船艦配置有傳輸裝置，傳輸裝置包括第一通訊模組、第二通訊模組與控制處理核心。第一通訊模組係用於與衛星通訊裝置進行通訊。第二通訊模組係用於與基地台進行通訊。控制處理核心用於判讀第二通訊模組是否能夠與基地台進行通訊。當第二通訊模組能夠與基地台進行通訊，則船艦使用第二通訊模組透過基地台與岸際計算中心進行資料傳輸，當第二通訊模組無法與基地台進行通訊，則船艦使用第一通訊模組透過衛星通訊裝置與岸際計算中心進行資料傳輸。
Patent TW-I816539-B (TW)
Inventor: CHUANG CHIA-CHENG
IPC: H01F41/04
Filed: 2022-09-02
Granted: 2023-09-21
Abstract: 一種共模濾波器，包含磁芯、第一導線及第二導線。第一導線纏繞於磁芯上，包含N圈，N為大於1的整數。第二導線纏繞在磁芯上，包含N圈。第一導線的第(S+1)圈堆疊在第一導線的內圈及第二導線的內圈之上，S為小於(N-1)的正整數。
Patent ZA-200005832-B (ZA)
Title: Use of a lysozyme dimer in fertility treatment and cell preservation.
Inventor: KICZKA WITOLD
IPC: C12N5/08
Filed: 1999-04-15
Abstract: The present invention relates to applications of a dimerized form of lysozyme for the improvement of impaired animal or human fertility. It further relates to the prevention or treatment of reproductive disorders in animals or humans and to the use of a lysozyme dimer for the manufacture of a pharmaceutical composition suitable for such applications, as well as to an improved method for the preservation of human or animal cells, particularly germ cells, and for prolongation of eukaryotic cell life.
Patent ZA-200108482-B (ZA)
Title: 3-deoxy-desmycosin derivatives and process for their preparation.
Inventor: NARANDJA AMALIJA
IPC: A61K31/7048
Filed: 2001-10-16
Abstract: The present invention relates to derivatives of 3-deoxy desmycosin of the formula I, wherein, starting from triply protected desmycosin, there are performed an oxidation at C-3 in the first step and then, optionally, a hydrogenation of double bonds and an epoxidation followed by a reductive opening of the oxirane ring. The present invention also relates to derivatives of 3-deoxy-desmycosin of the formula II, wherein in the first step triacetyl desmycosin is hydrogenated and then, via an intermediate mesylate, it is converted to a 2,3-didehydro derivative; or 2,3-didehydro-desmycosin is subjected to epoxidation reactions followed by a reductive opening of the oxirane ring.
Patent ZA-200202988-B (ZA)
Title: Sensors for the determination of organometallic compounds.
Inventor: TRILLO LUISA MARIA FRAGA
IPC: G01N21/78
Filed: 2002-04-16
Abstract: Sensors for the determination of organometallic compounds, e.g. n-butyllithium, comprise the following elements:   a)an inorganic, organic or polymeric support, insoluble in the sample to analyze b)an indicator which reversibly reacts with the organometallic compound and whose reaction product gives a characteristic absorption, reflection or emission band in the range 150-15000nm, e.g. 1,10-phenanthroline and derivatives, triphenylmethane, or N-Ä2-(4-hydroxybenzyl)phenylÜ-2,2-dimethylpropanamide, and which is physically trapped, adsorbed, absorbed, dissolved or chemically linked in an electrostatic or covalent way to the support c)an optical sensor which measures the absorption, reflection or emission of the functionalized support at the characteristic wavelength and transforms it in the concentration of the organometallic present in the solution. Also described is the method for the determination of the concentration of organometallic compounds by the on line use of a sensor in anionic polymerizations.
Patent ZA-200301134-B (ZA)
Title: Chlorine dioxide generator.
Inventor: MASON JOHN Y
IPC: B01F3/04
Filed: 2003-02-11
Abstract: A solid-state chlorine dioxide generator for generating an aqueous solution of ClO2 is formed within a block comprising an eductor for establishing a vacuum pressure and a reaction column for producing ClO2 from precursor chemicals. The eductor has a water stream flowing therethrough which establishes a vacuum pressure and draws the ClO2 from the reaction column into the water stream to form an aqueous ClO2 solution. The reaction chamber comprises a novel transition zone of increasing flow area wherein the precursor chemicals thoroughly mix resulting in conversion efficiencies of precursors into ClO2 of 95% and above.
Patent ZA-200304194-B (ZA)
Title: Combination therapy comprising anti-diabetic and anti-convulsant agents.
Inventor: CONNOR GREGORY S
IPC: A61K31/7008
Filed: 2003-05-29
Abstract: Combination therapy comprising anti-diabetic agents and anticonvulsant derivatives useful for the treatment of Type II diabetes mellitus and Syndrome X are disclosed.
Patent ZA-200308410-B (ZA)
Title: Retractablle prone supports for proning bed.
Inventor: BARTLETT ALAN L
IPC: A61G7/00
Filed: 2003-09-25
Abstract: A prone positioning therapeutic bed (10) comprises a base frame (16) and a patient support platform (20) rotatably mounted on the base frame (16) for rotational movement about a longitudinal rotational axis and a drive system for rotating the patient support platform on the base frame. A special head restraint apparatus (50) maintains proper patient alignment during rotation. A weight monitoring system monitors a patient's weight over time. A touch screen user interface provides a programmable therapy settings and displays statistics about past treatment. Circuitry is provided to minimise the risk that the failure of any single device or software program could endanger a patient. A "CPR" button is provided to arrest any program of therapy and return the patient support platform to a supine position. <IMAGE>
Patent ZA-200400750-B (ZA)
Title: Synthesis of enantiomerically pure amino-substituted fused bicyclic rings.
Inventor: MCEACHERN ERNEST J
IPC: C07D491/04
Filed: 2004-01-29
Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
Patent ZA-200402309-B (ZA)
Title: Levelling agent and anti-cratering agent.
Inventor: HEINRICH PIRRUNG FRANK OLIVER
IPC: C09D7/47
Filed: 2004-03-24
Abstract: Use of a polymer as a levelling agent or anti-cratering agent, said polymer comprising at least one fluorinated unit represented by formula l,Formula 1 wherein R?1¿ is a moiety represented by C¿n?F¿2n+l?-CH¿2?¿m?-, AC¿n?F¿2n?-CH¿2?¿m?-, C¿n?F¿2n+l?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-, AC¿n?F¿2n?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p'? C¿n?F¿2n+1?-CH¿2?¿m?-X-, AC¿n?F¿2n?-CH¿2?¿m?-X- AC¿n?F¿2n?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-X or C¿n?F¿2n+l?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-X- wherein A = H, Cl, Br, I, a C¿l-12? alkyl or a OC¿1-12 ?alkyl, wherein 4 <= n <= 20,0 <= m ~<= 4 and 0 <= p <= 20, wherein X is a spacer moiety selected from the group consisting of esters, amides, sulphoamides, mercapto groups, polyurethane groups and alkyl groups, wherein R?2¿ is H, a metal moiety, an alkylammonium moiety or an alkyl group, C¿n?F¿2n+l?-CH¿2?¿m?-, AC¿n?F¿2n?-CH¿2?¿m?-, C¿n?F¿2n+1?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-, AC¿n?F¿2n?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p'? C¿n?F¿2n+l?-CH¿2?¿m?-X-, AC¿n?F¿2n?-CH¿2?¿m?-X-, AC¿n?F¿2n?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-X or C¿n?F¿2n+l?-CH¿2?¿m?-OCH¿2?CHR?5¿¿p?-X- wherein A = H, Cl, Br, I, C¿1-12? alkyl or OC1-12 alkyl, wherein 4 <= n <= 20, 0 <= m <= 4 and 0 <= p <= 20, wherein X is a spacer moiety selected from the group consisting of esters, amides, sulphoamides, mercapto groups, polyurethane groups and alkyl groups, wherein R?3¿ and R?4¿ are independently selected from the group consisting of H, alkyl-groups and phenyl-groups and wherein R?5¿ is H and/or methyl group.
Patent ZA-200404664-B (ZA)
Title: Membrane filter housing and method of using the same
Inventor: FRANCISCUS NICOLAAS MARIE KNOPS
IPC: B01D/
Filed: 2004-06-11
Abstract: The invention relates to a membrane filter housing, comprising a housing (1) with a feed inlet (2), a permeate outlet (3) and at least two membrane filters (4,4',4'',4''') in the housing (1), wherein a fluid to be filtered is fed via the feed inlet (2) to the membrane filters (4,4',4'',4'''), and a permeate stream is discharged via the permeate outlet (3) and wherein one of the permeate outlet (3) and the feed inlet (2) is located at least at one end (I) of the membrane filter housing (1) and the other one is located at a position (II) substantially in the middle of the membrane filter housing (1).
Patent ZA-200406326-B (ZA)
Title: Safety lock with adjustable-length bolt.
Inventor: COMUNELLO VITTORIO
IPC: E05B63/06
Filed: 2004-08-10
Abstract: Safety lock for doors, gates or the like, comprising a box-shaped body ( 2 ) which contains and supports a bolt ( 5 ) able to slide between several operating positions ( 9, 10 ), actuating means ( 8 ) for displacing the bolt ( 5 ) between the above-mentioned position, a movable plate ( 15 ) capable of engaging by means of engaging means ( 17 ) inside seats ( 14 ) formed along the bolt ( 5 ) so as to retain it in the above-mentioned retracted and projecting positions. The lock ( 1 ) also has adjustment means ( 20 ) which are accessible from the outside of the box-shaped body ( 2 ) and are able to act on the movable plate ( 15 ) so as to engage it/disengage it with respect to the bolt ( 5 ) so as to allow the latter to be arranged with the part ( 5 a) projecting by the desired length. The movable plate ( 15 ) is mounted rotatably on the box-shaped body ( 2 ) about an axis of rotation (Z) by means of a pin ( 19 ); with respect to which it is able to rotate as a result of the action of adjustment means ( 20 ).
Patent ZA-200607729-B (ZA)
Title: Process for solids suspension and dosing
Inventor: DIERKES HERIBERT
IPC: D06M23/10
Filed: 2006-09-15
Abstract: The invention relates to a method for suspending and introducing solid matter in a high-pressure process, for example colorant pigments in a high-pressure process, in which a supercritical fluid is used as the process medium and a pressure in excess of 150 bar prevails. According to the invention, the suspension of the solid matter takes place at a low-pressure in a completely separate suspension method. In the latter, the solid matter is suspended or partially dissolved in a non-critical, liquid gas. The pressure in said suspension method is less than 90% of the critical pressure of the liquid gas. The suspension is introduced into the high-pressure process by means of a pump.
Patent ZA-200800034-B (ZA)
Title: O/w wax dispersions and plaster products obtainable from them
Inventor: GERNOT MEYER
IPC: C04B/
Filed: 2008-01-02
Abstract: The invention relates to O/W wax dispersions based on water, an emulsifier and a wax phase containing predominantly aliphatic hydrocarbons and polar compounds having chain lengths of at least 18 carbon atoms, and also plaster compositions comprising the O/W wax dispersion, and the use of the O/W wax dispersion.
Patent MX-337926-B (MX)
Title: An elastic composite, and a system and method for making the elastic composite.
Inventor: SMID ANNE
IPC: D04H3/04
Filed: 2007-08-22
Abstract: In one aspect, a method of making an elastic composite for incorporation into a disposable absorbent garment, textile or fabric structure, and the like is provided. The method comprises the steps of: conveying a first web of material along a first web plane moving path; conveying a second web of material along a second web plane moving path generally parallel with the first web plane moving direction; and applying a section of a continuous strand of elastic element onto both the first web and the second web along a direction generally transverse to the web plane moving paths.
Patent MX-336477-B (MX)
Title: Amino acid derivative.
Inventor: OOKUBO TOMOHIRO
IPC: A61K31/216
Filed: 2009-09-17
Abstract: Disclosed is a novel amino acid derivative having excellent analgesic activity. The amino acid derivative is a novel compound which exhibits excellent analgesic activity not only with respect to nociceptive pain model animals, but also with respect to neuropathic pain model animals, and is extremely useful as a medical agent for the treatment of various painful conditions that exhibit acute or chronic pain or neuropathic pain.
Patent MX-352634-B (MX)
Title: Methods of cementing in subterranean formations using cement kiln dust in compositions having reduced portland cement content.
Inventor: JITEN CHATTERJI *
IPC: C04B28/02
Filed: 2010-10-26
Abstract: The present invention includes methods of cementing in subterranean formations using cement kiln dust in compositions having reduced Portland cement content. An embodiment of a method comprises placing a sealant composition that comprises cement kiln dust and is essentially free of Portland cement in a subterranean formation; and allowing the sealant composition to set.
Patent MX-339162-B (MX)
Title: Trimmable catheter including distal portion stability features.
Inventor: BLANCHARD DANIEL B
IPC: A61M25/00
Filed: 2011-08-12
Abstract: A catheter tube for insertion into a body of a patient is disclosed. The catheter tube includes a distal portion that remains stable during fluid infusion into the patient, thus reducing or eliminating whipping of the catheter distal tip, even during power injection. In one embodiment, the catheter tube defines at least one lumen and is formed from a tube material that defines a proximal portion and a distal portion of the catheter tube. The catheter tube is configured such that the arithmetic product of an elastic modulus and an area moment of inertia for at least a portion of the distal portion of the catheter tube defined by the catheter tube material is greater relative the arithmetic product of an elastic modulus and an area moment of inertia for at least a portion of the proximal portion of the catheter tube.
Patent MX-351898-B (MX)
Title: Sulfur tolerant alumina catalyst support.
Inventor: ANDREW POLLI
IPC: B01D53/94
Filed: 2011-11-16
Abstract: The present invention is directed to a method for making a sulfur tolerant alumina, that includes the steps of: forming aluminum hydrate from one or more water soluble aluminum salts, said salts each comprising an aluminum cation or aluminum anion and an oppositely charged counterion, in an aqueous medium, contacting the aluminum hydrate with a silica precursor in the aqueous" medium and in the presence of counterions of the one or more aluminum salts, isolating silica precursor-contacted aluminum hydrate particles from the aqueous medium, and calcining the silica precursor-contacted aluminum hydrate particles to form particles of the sulfur tolerant alumina.
Patent MX-360554-B (MX)
Title: Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2.
Inventor: JINLING CHEN
IPC: A61K31/335
Filed: 2012-01-03
Abstract: Pharmaceutical dosage forms useful for improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as methods of their manufacture.
Patent MX-360666-B (MX)
Title: Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories.
Inventor: JASON STEIN
IPC: A61K31/79
Filed: 2012-05-11
Abstract: Disclosed are stable compositions comprising povidone-iodine and a steroid, and methods of making and using such compositions. Also disclosed herein are stable compositions comprising povidone-iodine and an NS AID, and methods of making and using such compositions.
Patent MX-350365-B (MX)
Title: Air cell and assembled cell using same.
Inventor: MORI NAGAYAMA
IPC: H01M50/514
Filed: 2012-09-13
Abstract: This air cell is provided with: a positive electrode layer; an electrolyte layer stacked on the positive electrode layer; a negative electrode layer stacked on the electrolyte layer; and an electroconductive liquid-tight ventilation layer stacked on the positive electrode layer, the electroconductive liquid-tight ventilation layer being positioned on the opposite side of the positive electrode from the electrolyte layer. This assembled cell is provided with a plurality of the air cells described above. The assembled cell is provided with a channel for channeling oxygen-containing gas, the channel being located between the electroconductive liquid-tight ventilation layer of a first air cell and the negative electrode layer of a second air cell adjacent to the first air cell. The first air cell is electrically connected, via the electroconductive liquid-tight ventilation layer, to the negative electrode layer of the second air cell.
Patent MX-346077-B (MX)
Title: Energy radiation generator with bi-polar voltage ladder.
Inventor: MATTHIEU SIMON
IPC: H05G1/32
Filed: 2012-09-14
Abstract: A well-logging tool may include a sonde housing, and a radiation generator carried by the sonde housing. The radiation generator may include a generator housing, a target carried by the generator housing, a charged particle source carried by the generator housing to direct charged particles at the target, and at least one voltage source coupled to the charged particle source. The at least one voltage source may include a voltage ladder comprising a plurality of voltage multiplication stages coupled in a bi-polar configuration, and at least one loading coil coupled at at least one intermediate position along the voltage ladder. The well-logging tool may further include at least one radiation detector carried by the sonde housing.
Patent MX-358390-B (MX)
Title: Humanized il-6 and il-6 receptor.
Inventor: ANDREW J MURPHY
IPC: C07K14/54
Filed: 2012-10-29
Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Ra locus of mouse ectodomain- encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.