baber/WOPTO huggingface dataset:
Patent EP-1015575-B1 (EP)
Inventor: BORCHERT TORBEN VEDEL
IPC: C12Q1/68
Filed: 1998-03-18
Granted: 2010-05-19
Abstract: The present invention relates to a new method of shuffling especially heterologous polynucleotide sequences, screening and/or selection of new recombinant proteins resulting therefrom having a desired biological activity, and especially to production and identification of novel proteases exhibiting desired properties. The method comprises the following steps; i) identification of at least one conserved region between the heterologous sequences of interest; ii) generating fragments of each of the heterologous sequences of interest, wherein said fragments comprise the conserved region(s), in a preferred embodiment due to the use of parts of the regions(s) as primers; and iii) shuffling/recombining said fragments using the conserved region(s) as (a) homologous linking point(s).
Patent EP-1009697-B1 (EP)
Inventor: SOLIGNAC JEAN-PIERRE
IPC: B65G65/46
Filed: 1998-02-13
Granted: 2002-10-30
Abstract: A device for metering dosed quantities of pulverulent products having a tank for storing the pulverulent products and a tubular duct extending to the tank. The tubular duct has a metering component for measuring the pulverulent product in the tank. The tubular duct serves to transport the product to a loading opening in the tank to a discharge opening. The outlet opening is combined with a blocking component that can be positioned on command between a blocking position and an open position.
Patent EP-0984970-B1 (EP)
Inventor: PETERS DAN
IPC: A61P21/02
Filed: 1998-05-29
Granted: 2003-11-19
Abstract: The present invention discloses compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein n is 1 or 2 or 3, A is -O-, -S-, -CH-, -O-CH2-, or -CH2-O-; B is -O-, -S-, -CH2-, -0-CH2-, or -CH2-O-; and C is N, or -CR1-; D is N, or -CR2-; E is N, or -CR3-; and F is N, or -CR4-; wherein R1, R2, R3 and R4 each independently are selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF3, OCF3, CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group. The compounds of the invention are useful for the treatment of disorders or diseases responsive to the activity of nicotinic ACh receptor modulators.
Patent EP-1000085-B1 (EP)
Inventor: CARPINO PHILIP ALBERT
IPC: C07D/
Filed: 1998-06-05
Granted: 2005-09-28
Abstract: La présente invention concerne un traitement de la résistance insulinique chez un mammifère, consistant en l'administration, au mammifère considéré, d'une quantité suffisante d'un composé représenté par la formule (I) dans laquelle les variables sont telles que décrites dans la spécification. Les produits administrés peuvent être également des mélanges stéréoïsomères, des isomères diastéréomériquement enrichis, des isomères diastéréomériquement purs, des isomères énantiomériquement enrichis, des isomères énantiomériquement purs, ou des sels ou bioprécurseurs pharmaceutiquement acceptables du composé considéré. Les composés représentés par la formule générale (I) sont des sécrétagogues d'hormone de croissance qui conviennent pour l'accroissement du niveau d'hormone de croissance endogène. Sous un autre aspect, l'invention concerne également, non seulement un certain nombre d'intermédiaires qui conviennent pour la synthèse des composés précités, mais aussi certains procédés convenant à la synthèse des intermédiaires considérés et des composés représentés par la formule générale (I). L'invention concerne enfin un procédé consistant en l'administration à un humain ou tout autre animal d'une combinaison d'un antagoniste fonctionnel de la somatostatine tel qu'un agoniste α-2 adrénergique et d'un composé représenté par la formule générale (I).
Patent EP-0983320-B1 (EP)
Inventor: PACHL JEFFREY T
IPC: C08G59/24
Filed: 1998-05-20
Granted: 2005-09-21
Abstract: A UV curable, flexible, paintable composition is disclosed. The disclosed composition has enhanced durability, thick and thin film adhesion, resistance to mold growth and dimensional changes while reducing solvent emissions. The disclosed composition reduces, if not eliminates, runs and drips during the thermal bake cycles which are associated with using conventional compositions in automotive applications.
Patent EP-1011695-B1 (EP)
Inventor: SCHMIDT RICHARD A
IPC: A61P15/00
Filed: 1998-07-15
Granted: 2006-03-22
Abstract: The present application is directed to the use of a therapeutically effective amount botulinum toxin in the preparation of a pharmaceutical composition for treating a patient with a neurogenic bladder dysfunction, wherein the composition is to be administered by injection into a bladder wall of a patient with said neurogenic bladder dysfunction, thereby treating a symptom of said neurogenic bladder dysfunction.
Patent EP-0966251-B1 (EP)
Inventor: AUDOUSSET MARIE-PASCALE
IPC: A61Q5/10
Filed: 1998-07-16
Granted: 2005-12-14
Abstract: The subject-matter of the present invention is a composition for the oxidation dyeing of keratinous fibres, in particular of human keratinous fibres, such as hair, comprising 2-chloro-6-methyl-3-aminophenol as coupler, in combination with at least two oxidation bases which are different from one another, and the dyeing process employing this composition with an oxidizing agent.
Patent EP-1007686-B1 (EP)
Inventor: KAUFMANN STEFAN H E
IPC: C12N15/62
Filed: 1998-08-12
Granted: 2006-12-06
Abstract: The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
Patent EP-1028751-B1 (EP)
Inventor: RAJU T SHANTHA
IPC: C12P21/00
Filed: 1998-10-16
Granted: 2008-12-31
Abstract: This invention relates to novel glycoprotein glycoform preparations comprising the substantially homogeneous glycoprotein glycoforms and combinations thereof. More particularly the invention relates to glycoprotein preparations comprising a particular Fc glycoforms and methods for producing, detecting, enriching and purifying the glycoforms. The invention further relates to immunoglobulins and especially antibodies comprising a CH2 domain having particular N-linked glycans. Provided are compositions including pharmaceutical compositions methods of using the preparations as well as articles of manufacture comprising the preparations.
Patent EP-0947313-B1 (EP)
Inventor: PANZER ULF DR
IPC: B32B27/12
Filed: 1999-03-25
Granted: 2007-05-09
Abstract: Textile laminate with a water vapor permeability of more than 1000 (preferably more than 1800) g/m <2> per 24 hours and a water tightness corresponding to a water column of more than 500 mm (preferably more than 750) mm comprises: (A) a sheet of woven, knitted or nonwoven fabric based on polyethylene, polypropylene, polyethylene terephthalate, polyamide, cellulose or cotton; (B) a film or extruded coating with a thickness of 3-200 (preferably 5-70) mu m based on polypropylene and containing 0.01-2.5 wt.% stabilizers, 0.01-1 wt.% processing aids and optionally 0.1-1 wt.% antistatic, 0.2-3 wt.% pigments, 2-20 wt.% flame retardants and/or 0.05-1 wt.% nucleating agents and/or 10-70 (preferably 20-50) wt.% (in)organic fillers and/or reinforcers; and optionally (C) an adhesive layer between (A) and (B), having a thickness of 0.5-20 (preferably 1-10) mu m and comprising a polar olefin polymer and/or an olefin graft copolymer, e.g. a copolymer of ethylene with vinyl acetate or (meth)acrylic acid or polyethylene or polypropylene grafted with an unsaturated carboxylic acid or anhydride. The film or extruded coating is based on either: (1) a polymer blend comprising (a) 1-50 (preferably 5-30) wt.% of a modified propylene polymer with a melt flow index of 0.1-50 (preferably 1-40) g/10 minutes at 230 degrees C and 2.16 kg, where the ratio of the limiting viscosity of the modified polypropylene to that of an unmodified polypropylene with approximately the same molecular weight is 0.2-0.95; and (b) 50-99 (preferably 70-95) wt.% of a polymer selected from (i) propylene homopolymers and/or copolymers (statistical and/or block copolymers) with ethylene and/or 4-18C  alpha -olefins, with a propylene content of 80-99.9 wt.%, preferably producing using Ziegler-Natta or metallocene catalysts, with a melt flow index of 0.1-300 (preferably 1-150) g/10 minutes at 230 degrees C and 2.16 kg; and/or (ii) polyolefin mixtures with a Mn/Mw ratio of 2-6 and a melt flow index of 1-40 g/10 minutes at 230 degrees C and 2.16 kg, comprising 60-98 wt.% of a crystalline copolymer of 85-99.5 wt.% propylene and 0.5-15 wt.% ethylene or 4-10C  alpha -olefin and 2-40 wt.% of an elastic copolymer of 20-70 wt.% ethylene and 30-80 wt.% propylene and/or 4-10C  alpha -olefin; and/or (iii) amorphous propylene (co)polymers that contain less than 10 wt.% crystalline phase, have an enthalpy of melting below 40 J/g, have a melt flow index of 0.1-100 g/10 minutes at 230 degrees C and 2.16 kg and comprise at least 80 mole % propylene and no more than 20 mole % 4-10C  alpha -olefin; and/or (iv) non-isotactic polypropylene having a melting point of 145-165 degrees C, a melt viscosity of more than 200,000 cP at 190 degrees C, a heat of crystallization of 4-10 cal/g and an ether soluble content of 35-55 wt.%; or (2) a polymer blend comprising only the components of (b), comprising 0-95 wt.% (i) and 5-100 wt.% (ii)+(iii)+(iv).
Patent EP-0953358-B1 (EP)
Inventor: MEFFERT HELMUT DR
IPC: C08F226/10
Filed: 1999-03-25
Granted: 2007-01-03
Abstract: The use of copolymers comprisinga) 50 to 99% by weight of at least one N-vinyllactam or N-vinylamine selected from the group consisting of N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, N-vinylimidazole and methylated N-vinylimidazole or N-vinylformamide andb) 1 to 50% by weight of at least one monomer selected from the group ofb1) C14-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids;b2) N-C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids;b3) N,N-C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids;b4) vinyl esters of aliphatic C8-C30-carboxylic acids;b5) C8-C30-alkyl vinyl ethersas matrix for producing solid pharmaceutical and cosmetic presentations.
Patent EP-1038460-B1 (EP)
Inventor: PFERDEHIRT THOMAS
IPC: A44B17/00
Filed: 1999-03-25
Granted: 2003-11-26
Abstract: The press fastener eyelet is formed by a substantially annular, plastic moulding (1) having said central perforation (5) and comprising a round ball reception area (2) and a temporarily widenable locking area (3) which tapers towards the insertion end for the press fastener ball and extends roughly coaxially to said ball reception area (2). Said plastic body comprises a ring flange-like outer edge, to which is connected in axially displaced manner the central area having the central perforation. Moreover, an all-round groove (7) increasing the resilient action of the locking area is provided in the ring flange-like outer edge of the plastic body radially outside the locking area (3), with the locking area (3) being constructed polygonally. The plastic moulding may advantageously be moulded from POM (polyoxymethylene). <IMAGE>
Patent EP-1002680-B1 (EP)
Inventor: GEHRINGHOFF LUDGER
IPC: B60J5/04
Filed: 1999-11-16
Granted: 2003-07-16
Abstract: An automobile door frame, has window well stiffeners (8, 9, 10) in the form of oval tubes. An automobile door frame has a window well (1) bounded by exterior and interior door panels (2, 3) provided with stiffeners (8, 9) extending along the window well adjacent the window opening (5), the stiffeners being formed by oval tubes conforming with the inner surfaces (6, 7) of the exterior and interior door panels (2, 3).
Patent EP-1093054-B1 (EP)
Inventor: CHANTRAIN DOMINIQUE HELENA LUC
IPC: G06F13/00
Filed: 1999-10-15
Granted: 2008-07-16
Abstract: The present invention provides a method and related devices for installing software components at a user-terminal of a plurality of user-terminals in a communications-network. This communications network further consists of a plurality of hosts and a plurality of network gateways. The user-terminal is connected to one of the network gateways. The network gateway receives a connection request from a user-terminal to establish a connection between the user-terminal and one of the hosts and detects if the software components are available at the user-terminal. If the software components are not available, the network gateway sets the establishment of the connection between the user-terminal and the host in hold and subsequently establishes a connection between the user-terminal and a service provisioning network element that also is included in the communications network. The service provisioning network element downloads the software components to the user-terminal over a established connection between the user-terminal and the service provisioning network element. The network gateway resumes the establishment of the connection between the user-terminal and the host upon detection of the end of the download. <IMAGE>
Patent EP-1047645-B1 (EP)
Inventor: STANSSENS DIRK ARMAND WIM
IPC: C03C25/26
Filed: 1999-01-15
Granted: 2007-03-07
Abstract: Compound or salts thereof suitable for use as a binder for mineral fibers, for example glass or stone wool, said compound containing a carboxylic acid group and/or a beta-hydroxyalkyl amide group.
Patent EP-1070256-B1 (EP)
Inventor: MALLET FRANCOIS
IPC: G01N33/551
Filed: 1999-04-12
Granted: 2004-09-22
Abstract: The invention concerns a method for fixing a biological molecule, associated with a specific binding site, on the surface of a support made of silica or metal oxide. The invention also concerns a surface functionalised by the method and the use of such a surface. The method is characterized in that it consists in: functionalising the surface by cleaning, using at least a solvent or an oxygen plasma or any other process for forming alcohol groups on the support surface, to make it hydrophilic; contacting the biological molecule on said functionalised surface, and functionalising the support by fixing the biological molecule specific binding site on at least one of the support alcohol groups. The invention is particularly useful in the field of biomedical diagnosis.
Patent EP-1073491-B1 (EP)
Inventor: ANDERSSON MALIN
IPC: A61M15/00
Filed: 1999-03-26
Granted: 2004-11-03
Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a housing (22) which defines a cavity (34) for receiving a canister (8) which comprises a body (10) which defines a chamber containing medicament and a valve stem (13) which extends from the body (10), the body (10) and the valve stem (13) of the canister (8) being relatively movable between a first, non-actuated position in which the canister (8) is closed and a second, actuated position in which the canister (8) is open; a nozzle block (24) for receiving the valve stem (13) of the canister (8); a mouthpiece (21) for providing medicament from the nozzle block (24) to the mouth of a user; a locking mechanism (16) for selectively locking the canister (8) in the non-actuated position, which locking mechanism (16) when released allows for the actuation of the canister (8); and a loading mechanism (18) which comprises a biasing element (134) for loading one of the body (10) or the valve stem (13) of the canister (8) with an actuating force for actuating the same and a lever arm (132) which is pivotally coupled to the housing (22) for loading the biasing element (134) when rotated in one sense, which lever arm (132) is configured so as to be rotated in the one sense on the manual application of opposed forces substantially orthogonal to the longitudinal axis of the canister (8).
Patent EP-1068485-B1 (EP)
Inventor: CARLI CARLO
IPC: G01B7/012
Filed: 1999-03-29
Granted: 2002-06-12
Abstract: A head for the linear dimension checking of pieces in machine tools or measuring machines with a support structure (1), a movable arm-set (4) including an arm (6) carrying a feeler (8) for contacting the piece (37) to be checked, a spring (17) arranged between the support structure and the movable arm-set, a first annular surface (19) fixed to the support structure, a second annular surface (18) fixed to the movable arm-set and urged by the spring into contact with the first annular surface and an electric detecting device. The detecting device includes a ring (16) made of electrically resistive material that defines the first annular surface and another ring (13) made of electrically resistive material that defines the second annular surface, a circuit (21) for applying a difference of potential across two points (22, 23) of the first ring and another circuit (30) for detecting the difference of potential across two points (24, 25) of the other ring.
Patent EP-1090461-B1 (EP)
Inventor: WALKER BRETT CHRISTOPHER
IPC: H03C3/40
Filed: 1999-06-29
Granted: 2005-12-14
Abstract: A method and apparatus for adaptively correcting D.C. offset errors imposed upon signals in a communication device. The present invention includes a feedback loop correction circuit and method for measuring and reducing D.C. offset errors imposed upon analog transmission signals by transmit digital-to-analog converters (DACs) and associated analog reconstruction filters. A digital feedback loop is used to remove the D.C. offset errors from the analog transmission signals prior to transmission. In the preferred embodiment, the digital feedback loop includes a pair of analog-to-digital converters, a digital D.C. offset correction circuit, and a pair of adders. The transmission signals are digitized, filtered, and digitally processed by the correction circuit to generate offset correction signals that are equal to the undesired D.C. offset error present in the transmission signals. The correction signals are added to the digital input baseband signals thereby removing the undesirable D.C. offset errors from the transmission signals. In one preferred embodiment, the analog-to-digital converters comprise differential comparators that generate digital signals representative of the signs of the analog transmission signals. The digital D.C. offset correction circuit processes the digital signals output by the differential comparators using a selected digital signal processing technique. In one embodiment, the offset correction circuit uses a "sign bit" digital signal processing technique whereby the sign bits generated by the differential comparators are continuously integrated. The preferred embodiment of the present invention uses an MSB technique whereby sign characteristics of both the digital baseband signals and associated transmission signals are analyzed to produce the feedback correction signals. In accordance with this technique, integrators are disposed to measure zero crossing time delays between the baseband signals and the filtered signals. The zero crossing time delays are measured by analyzing the relative signs of the baseband signals and the filtered signals. The zero crossing time delays are used in the preferred embodiment as an estimate of the D.C. offset errors present in the transmission signals.
Patent EP-1096880-B1 (EP)
Inventor: BLES WILLEM
IPC: A61B5/103
Filed: 1999-07-14
Granted: 2010-03-17
Abstract: Device for performing a test supplementary to neurological examination, which determines whether a cervical acceleration injury has occurred, which device comprises a platform connected non-movably to a fixed ground for supporting a person, a visually manipulable environment in which the person is placed, in addition to sensors connected to the platform and/or to the person for measuring postural corrections of the person, and computing means connected to the sensors, wherein means are arranged for comparing the values generated by the sensors with standard values in order to obtain a measure for the visual dependency of the person; and a method of determining a cervical acceleration injury. With the invention measurements can be performed in objective manner with which an objective judgment in respect of the presence of a cervical acceleration injury in the person in question can be obtained.
Patent EP-1131124-B1 (EP)
Inventor: MEHIER HENRI
IPC: A61M25/00
Filed: 1999-09-21
Granted: 2006-01-18
Abstract: The invention concerns a device for directly delivering an active substance within all or part of a human or animal tissue cell, characterised in that it is in the form of a hollow tube (1), whereof the walls in contact with said tissue are provided with perforations (5) and whereof the distal end (2) is sealed, while the proximal end (3) is shaped so as to receive removable closing means, said tube being capable of bearing a pressure of at least 50 bars.
Patent EP-1117862-B1 (EP)
Inventor: LINDQVIST KENNETH
IPC: D06F43/00
Filed: 1999-08-27
Granted: 2004-07-21
Abstract: A method for cleaning or sterilizing objects in a liquid fluid cleaning system comprising a high-pressure storing/working vessel, a cleaning chamber, and a low-pressure supply vessel, the method comprising the steps of loading the cleaning chamber with objects to be cleaned or sterilized; supplying cleaning fluid to the cleaning chamber from the low-pressure supply vessel by means of pressure difference; supplying cleaning fluid to the cleaning chamber from the high-pressure storing/working vessel; cleaning the objects in the cleaning chamber with the cleaning fluid; transferring cleaning fluid from the cleaning chamber to the high-pressure storing/working vessel; and unloading the cleaned objects from the cleaning chamber.
Patent EP-1078220-B1 (EP)
Inventor: FOESSEL SIEGFRIED
IPC: G06T7/30
Filed: 1999-05-11
Granted: 2002-11-27
Abstract: An area, such as an area of the earth's surface, is scanned by a scanner, such as an infrared line scanner, which is moved over the area at different heights and at different speeds. An overscan factor is determined in accordance with the height and speed of the scanner over the scanned area. A first image is centered, and an offset vector between the first image and a subsequently scanned second image is calculated in accordance with an image offset. The first and second images are aligned with one another in accordance with the offset vector. The image content of the aligned images are averaged with one another in overlapping image areas defined by the overscan factor.
Patent EP-1135780-B1 (EP)
Inventor: SITBON ERIC
IPC: A45C13/10
Filed: 1999-12-03
Granted: 2006-03-01
Abstract: The invention relates to a device ( 1 ) for holding together, adjusting, fitting or fastening parts of a garment, shoe or any other accessory. It contains a first part ( 2 ) comprising a sheath ( 3 ) in which a first magnet or ferromagnetic element ( 4 ) is inserted, these being movable inside the first sheath, and a second part ( 5 ) containing a second magnet or ferromagnetic element ( 6 ) subject or submitted to the magnetic attraction of the first magnet or ferromagnetic element of the first part, and is used to hold together, adjust, fit or fasten the garment, shoe or accessory when one of the said first and second parts ( 2, 5 ) is activated by a user to work in conjunction or alterations is thus possible through the sliding ( 7 ) of the first magnet or ferromagnetic element ( 4 ) in the first sheath ( 3 ).