Patent SG-11201810287R-A (SG)
Title: Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
Inventor: SAHA SAURABH
IPC: A61P37/04
Filed: 2017-05-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H11101111111111111111111111111100101011111011111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .......'\"\" WO 2017/201532 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/4439 (2006.01) A61P 31/12 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/675 (2006.01) A61P 37/04 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, A61P 9/10 (2006.01) A61P 37/06 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/US2017/033843 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 22 May 2017 (22.05.2017) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 15/161,137 20 May 2016 (20.05.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicant: BIOMED VALLEY DISCOVERIES, INC. TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [US/US]; 4520 Main Street, 16th Fl., Kansas City, Missouri EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 64111 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, _ (72) Inventors: SAHA, Saurabh; 44 Carisbrooke Road, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Wellesley Hills, Massachusetts 02481 (US). WELSCH, KM, ML, MR, NE, SN, TD, TG). Dean; 10427 NW River Hills Place, Parkville, Missouri 64152 (US). DECRESCENZO, Gary; 6135 Westwood Published: = Court, Parkville, Missouri 64152 (US). ROIX, Jeffrey — with international search report (Art. 21(3)) James; 658 E. Broadway St., Apt. 2, Boston, Massachusetts — with sequence listing part of description (Rule 5.2(a)) = _ 02127 (US). = (74) Agent: HOOPER, Kevin C.; Bryan Cave LLP, 1290 Av- enue of the Americas, New York, New York 10104 (US). = _ = = Title: METHODS AND COMPOSITIONS FOR TREATING NON-ERK MAPK PATHWAY INHIBITOR-RESISTANT CAN- (54) = CERS = = = FIG. lA = = Trametinita ent$ = = Tratnettnib = _ 'fram + Dab 4 Tram i , BVD••523 = 2 . 1-1 .4 t , ‘' % Miag40044$44 ei en %..t..w. 1-1 fi 5 1: 15 211 25 3_1 34 40 0 ei Time (days) IN - (57) : The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which cancer is refractory or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided ei are methods for identifying a subject having cancer who would benefit from therapy with an ERK inhibitor and methods for inhibiting 0 phosphorylation of RSK in a cancer cell that is refractory or resistant to a non-ERK MAPK pathway inhibitor.