Patent RU-2544010-C2 (RU)
Inventor: TsJu Jao-lin
IPC: A61K31/4184
Filed: 2010-03-01
Granted: 2015-03-10
Abstract: FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formula:,wherein: each D and Z is independently absent or represents an optionally substituted linear aliphatic group containing zero to eight carbons, wherein 'aliphatic' refers to an alkyl, alkenyl or alkynyl group, and 'optionally substituted' refers to substituting by replacing independently one, two or more hydrogen atoms by substitutes specified in -F, -Cl, -Br, -I, -OH, -NO, -N, -CN, -NH, -NH-C-C-alkyl, -NH-C-C-alkenyl, -NH-C-C-alkynyl, -NH-C-C-cycloalkyl, -dialkylamino, -O-C-C-alkyl, -NHC(O)-C-C-alkyl, -NHC(O)-C-C-alkenyl, -NHC(O)-C-C-alkynyl, -NHC(O)-C-C-cycloalkyl; each A and E is independently absent or represents a cyclic group with the above cyclic group is independently specified in a group consisting of aryl or heteroaryl, each of which is optionally substituted; 'aryl' refers to phenyl, naphthyl, tetrahydronaphthyl, indanyl or idenyl; 'heteroaryl' refers to pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, furanyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl or quinoxalinyl; 'optionally substituted' refers to substituting by replacing independently one, two, three or more hydrogen atoms by substitutes specified by -F, -Cl, -Br, -I, -OH, -NO, -N, -CN, -NH, -NH-C-C-alkyl, -NH-C-C-alkenyl, -NH-C-C-alkynyl, -NH-C-C-cycloalkyl, -dialkylamino, -O-C-C-alkyl, -NHC(O)-C-C-alkyl, -NHC(O)-C-C-alkenyl, -NHC(O)-C-C-alkynyl, -NHC(O)-C-C-cycloalkyl; T is absent or represents an optionally substituted aliphatic group containing 1 to 24 carbons; 'aliphatic' refers to an alkyl, alkenyl or alkynyl group; 'optionally substituted' refers to substituting substituting by replacing independently one, two, three or more hydrogen atoms by substitutes specified in -F, -Cl, -Br, -I, -OH, -NO, -N, -CN, -NH, -NH-C-C-alkyl, -NH-C-C-alkenyl, -NH-C-C-alkynyl, -NH-C-C-cycloalkyl, -dialkylamino, -O-C-C-alkyl, -NHC(O)-C-C-alkyl, -NHC(O)-C-C-alkenyl, -NHC(O)-C-C-alkynyl, -NHC(O)-C-C-cycloalkyl; one to four of A, D, E, T and Z are absent; the ring B is specified in imidazolyl, pyrazolyl, 1,3,4-thiazolyl, and 1,3,4-oxadiazolyl, and the ring B is bound to J through atom C and bound to Z, E, T, A and D through atom C; in each specific case, Ris independently specified in a group consisting of hydrogen, halogen, cyano optionally substituted by C-Calkyl, -O-R, -NRR, -C(O)R, -CORand -C(O)NRR; in each specific case, Rindependently represents hydrogen or optionally substituted C-Calkyl; in each specific case, each Rand Rare independently specified in hydrogen, C-Calkyl and C-Calkenyl; u is independently equal to 1, 2 or 3; Q and J representRis specified in a group consisting of -C(O)-R, -C(O)-C(O)-R, -S(O)-R, and -C(S)-R; in each specific case, Ris independently specified in a group consisting of -O-R, -NRR, and -R; and in each specific case, Ris independently specified in a group consisting of: hydrogen, C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl and C-Ccycloalkenyl, each of which is optionally substituted; 'optionally substituted' refers to substituting independently by replacing one, two, three or more hydrogen atoms by substitutes specified in -F, -Cl, -Br, -I, -OH, -NO, -N, -CN, -NH, -NH-C-C-alkyl, -NH-C-C-alkenyl, -NH-C-C-alkynyl, -NH-C-C-cycloalkyl, -dialkylamino, -O-C-C-alkyl, -NHC(O)-C-C-alkyl, -NHC(O)-C-C-alkenyl, -NHC(O)-C-C-alkynyl, -NHC(O)-C-C-cycloalkyl, which inhibit an RNA-containing virus, particularly hepatitis C virus (HCV).EFFECT: preparing hepatitis C inhibitors.38 cl, 22 tbl, 516 ex