baber/WOPTO huggingface dataset:
Patent DK-1222171-T3 (DK)
Inventor: SANKARANARAYANAN ALANGUDI
IPC: A61P43/00
Filed: 1999-10-15
Granted: 2004-07-05
Abstract: Pyridinium derivatives (I) and their salts are new. Pyridinium derivatives of formula (I) and their salts are new: [Image] R 1R 4R 5 or N(R 7)N(R 7)R 9; R 4N(R 7)R 6O, N(R 7)R 6N(R 7), OR 6O, or OR 6N(R 7); R 6alkyl; R 5alkyl, aryl, heteroaryl, COR 7, SO 2R 7, C(S)NHR 7, C(NH)NHR 7, C(O)R 1 0, C(O)NHR 7, or N(R 7)N=C(R 7)R 1 0; R 7,R 1 0H, alkyl, aryl or heteroaryl (provided that the N of the heteroaryl, when present, of R 1 0 is optionally quarternized with compounds such as X-CH 2C(O)R 3; R 2F, Cl, Br, I, OR 7, NO 2, alkyl, aryl, heteroaryl, formyl, acyl, C(O)NR 7R 1 0, CO 2R 7, NR 7R 1 0, N=C(R 7)R 1 0, SR 7, SO 2NH 2, SO 2-alkyl or SO 2-aryl; m : 0-2; R 3R 7, OR 7, NR 7R 1 0, N=C(R 7)R 1 0, N(R 7)NR 7R 1 0, N(R 7)N=C(R 7)R 1 0 or CH(R 7)C(O)R 8; R 8R 7, OR 7 or NR 7R 1 0; R 9H, alkyl, aryl, heteroaryl, C(O)R 1 0, SO 2R 1 0, C(S)NHR 1 0, C(NH)NHR 1 0, or C(O)NHR 1 0; and X : halide, acetate, perchlorate, sulfate, oxalate, citrate, tosylate, maleate, mesylate, carbonate, sulfite, phosphoric hydrogen, phosphonate, phosphate, BF 4 -> or PF 6 -> (provided that when 2 alkyl groups are present on the same C or N, they may link together to form a cycloalkyl group). Independent claims are also included for: (a) a process for the preparation of (I) comprising preparing the properly substituted pyridine derivative followed by quarternization; (b) the use of (I) in the manufacture of a medicament for diabetic complications and aging-related diseases including kidney disease, nerve damage, retinopathy, artherosclerosis, microangiopathy, endothelial dysfunctions, dermatological conditions, discoloration of teeth and other organ dysfunctions; (c) a method for treating a diabetic patient by breaking preformed advanced glycation end products (AGE) comprising administration of (I) either singly or in combination with another drug. ACTIVITY : Antidiabetic; nephrotropic; neuroprotective; ophthalmological; antiarteriosclerotic; dermatological; dental. Tests were performed to study the efficacy of (I) in the inhibition of advanced glycation end products (AGE) breaker activity. Bovine serum albumin (160 mg/ml) and glucose sugar (1.6 M) were dissolved in phosphate buffered saline. Sodium azide was added at 0.2 % concentration. The solution was filtered and kept for aging at 37 [deg] C for 16 weeks. After 16 weeks the solution was dialyzed against PBS, aliquoted and stored at -20 [deg] C. The AGE breaking activity of N,N'-bis[3-carbonyl-1-(2-phenyl-2-oxoethyl)pyridinium]hydrazine dibromide (Ia) at 5 mM was tested, and found to be 13 %. MECHANISM OF ACTION : None given.
Patent ES-2241511-T3 (ES)
Inventor: HOCKER EITEL-FRIEDRICH
IPC: E06B3/54
Filed: 2000-01-12
Granted: 2005-11-01
Abstract: Sealing lips (10, 12) extend from the longitudinal sides faces (11) of a core (4) with at least one cavity (5). Outer lips cover the external opening of the gap (2) and additional sealing lips support the glass sheet or panel surfaces (13) defining the gap. An anchoring extension (15) attaches the seal to a groove (8) of the supporting structure.
Patent ES-2223379-T3 (ES)
Title: Cabezal de congelacion para aparatos de congelacion de tubos.
Inventor: WAGNER RUDOLF DR
IPC: F16L55/10
Filed: 2000-11-23
Granted: 2005-03-01
Abstract: Cabezal de congelación para aparatos de congelación de tubos, con al menos una cavidad (7, 8) prevista en una cara exterior para acoger un tramo (9, 10) de tubo y con al menos una conexión (19) para la alimentación de un fluido refrigerante en al menos un espacio (27, 28) hueco del cabezal de congelación, presentando el cabezal de congelación en otra cara exterior al menos otra cavidad (7, 8), caracterizado porque el fondo (11, 14) de las cavidades (7, 8) presenta en todos los casos al menos dos tramos (12, 13; 15, 16) de fondo que tienen diferentes radios de curvatura.
Patent ES-2235774-T3 (ES)
Inventor: CRAIG THOMAS ORR
IPC: C08F6/00
Filed: 2000-02-28
Granted: 2005-07-16
Abstract: A process for the removal of impurities from a thermoplastic polymer, comprising mixing with the polymer in a molten state a stripping agent comprising a solution of carbon dioxide in water, passing the mixture to a vessel held at a pressure and which is less than atmospheric pressure, allowing impurities to defuse out of the polymer into the volatilised stripping agent, and removing the volatilised stripping agent with the impurities from the mixture. The invention also relates to the stripping agent itself, which is a solution of carbon dioxide in water. <IMAGE>
Patent ES-2244403-T3 (ES)
Inventor: KIRCHHOFER FRITZ
IPC: A61M5/24
Filed: 2000-01-11
Granted: 2005-12-16
Abstract: The invention refers to a device for administering an injectable product in doses, comprising a casing, itself comprising: a reservoir for the product; a piston which forces product out of the reservoir when moved in a feed direction towards a reservoir outlet; a drive member; a driven member which is slaved by the drive member when the drive member is moved in the feed direction, so moving the piston in the feed direction; and a dosing member which may be rotated about the sliding axis of the drive member, to set the product dosage to be administered. The drive member and the dosing member abut each other via at least one dosage stopper each, one of which is provided on the drive member and the other on the dosing member. At least one of these dosage stoppers at least partially encircles the sliding axis of the drive member in the form of a spiral. The at least one spiral dosage stopper exhibits a continuous course with a constant pitch alpha.
Patent ES-2195855-T3 (ES)
Inventor: ARANA DAVID
IPC: C21C1/02
Filed: 2000-01-26
Granted: 2003-12-16
Abstract: The present invention relates to an apparatus and a process to extract heat and to solidify molten material particles. A flow of molten material is traversed by a high pressure dispersing/cooling flow to form particles of molten or semi-molten material. The particles impinge against a transporting device, which transport them to a collecting place. The transporting device is provided with a vibrator, which provides a vibrating movement to the transporting device to prevent the particles which are still cooling-off from being agglomerated again. A flow of a low pressure dispersing/cooling could be provided, which substantially transversely traverses said flow of particles of molten or semi-molten material which fall towards the transporting device, in order to enhance the dispersion and cooling-off effects of the particles. A hopper could be provided to collect the particles and to carry them to the transporting device. Cooling water pipes could be provided to eject a flow of cooling water onto the internal walls of the hopper and also onto the transporting device, which assist cooling of the dispersed particles.
Patent ES-2263462-T3 (ES)
Inventor: NIERICH ARNO
IPC: A61B8/00
Filed: 2000-03-10
Granted: 2006-12-16
Abstract: The invention relates to an ultrasonic imaging system (6) comprising an ultrasound endoscope device (7) for scanning a patient's organs (9), in particular for use in transesophageal echocardiography, associated with a separate transmission device (8) defining a transmission path for sound waves originating from the endoscope device. The invention further relates to a transmission device (8) specially adapted for use in association with an endoscope device (7) in an ultrasonic imaging system (6) comprising a flexible balloon member (13) connected to a supply line (10) for a sound wave transmission fluid medium. The invention also relates to the use of an ultrasonic imaging system (6) and a method for ultrasonic scanning a patient's organs (9) in particular in transesophageal echocardiography. <IMAGE>
Patent ES-2237452-T3 (ES)
Inventor: BARTHOLEYNS JACQUES
IPC: C12N5/08
Filed: 2000-08-22
Granted: 2005-08-01
Abstract: The invention relates to humanized biomaterial comprising a porous biocompatible composite material customized and implanted with monocyte derived cells preferably with macrophages.
Patent ES-2367005-T3 (ES)
Inventor: KUBOTA HIROSHI
IPC: A61K35/12
Filed: 2000-10-03
Granted: 2011-10-27
Abstract: A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class I antigen(s) can be used for further enrichment of hepatic progenitors. Furthermore, the progenitors can be selected to have a level of side scatter a measure of granularity or cytoplasmic droplets, that is higher than that in non-parenchymal cells, such as hemopoietic cells, and lower than that in mature parenchymal cells, such as hepatocytes. Furthermore, the progeny of the isolated progenitors can express alpha-fetoprotein and/or albumin and/or CK19. The hepatic progenitors, so isolated, can grow clonally, that is an entire population of progeny can be derived from one cell. The clones of progenitors have a growth pattern in culture of piled-up aggregates or clusters. These methods of isolating the hepatic progenitors are applicable to any vertebrates including human. The hepatic progenitor cell population is expected to be useful for cell therapies, for bioartificial livers, for gene therapies, for vaccine development, and for myriad toxicological, pharmacological, and pharmaceutical programs and investigations.
Patent ES-2225243-T3 (ES)
Inventor: BILYK ALEXANDER
IPC: C08J7/04
Filed: 2000-10-19
Granted: 2005-03-16
Abstract: A method of modifying a polymeric surface of a substrate including: (i) providing the polymeric surface with functional groups; and (ii) contacting the surface with (a) a polyamine compound reactive with the surface functional groups, said polyamine comprising at least four amine groups including at least two amine groups selected from primary and secondary amine groups, and (b) crosslinking agent reactive with the polyamine to provide a crosslinked network grafted to the substrate surface.
Patent ES-2213054-T3 (ES)
Title: Procedimiento para la separacion adhesiva de uniones por pegado.
Inventor: KIRSTEN CHRISTIAN
IPC: C09J9/00
Filed: 2000-10-18
Granted: 2004-08-16
Abstract: Composición de imprimación electromagnéticamente activable, caracterizada porque el aglutinante contiene adicionalmente partículas en escala nanométrica con propiedades ferromagnéticas, ferrimagnéticas, super paramagnéticas ó piezoeléctricas.
Patent ES-2218250-T3 (ES)
Title: Herramienta de presion y metodo para presionar sobre una pelicula para adherirla a un sustrato.
Inventor: BOGMAN FRANS WIRTJE
IPC: B44C1/10
Filed: 2000-11-02
Granted: 2004-11-16
Abstract: Herramienta de presión (1) para presionar sobre una película (10) para adherirla a un sustrato (12) que comprende una parte portadora (2) rígida y relativamente dura con una superficie de presión (4) con la que, durante la utilización, la película (10) puede ser presionada contra el sustrato (12), estando dicha superficie de presión (4) provista parcialmente, por lo menos, de una capa intermedia de baja fricción, caracterizada porque la capa intermedia comprende una capa amortiguadora (6) elástica, relativamente blanda.
Patent ES-2338860-T3 (ES)
Title: Sistema y procedimiento de administracion de anticonceptivos transdermica mejorado.
Inventor: CHIEN TE-YEN
IPC: A61K9/70
Filed: 2000-11-22
Granted: 2010-05-13
Abstract: Un sistema de administración de anticonceptivos transdérmico que comprende una capa de respaldo y una matriz polimérica adhesiva fija a la capa de respaldo, que tiene dispersadas en ésta hormonas efectivas para controlar fertilidad y una combinación efectiva de potenciadores de permeación cutánea, en el que la matriz polimérica adhesiva comprende un polímero adhesivo, un humectante/plastificante, la combinación de agentes potenciadores de permeación cutánea que comprende dimetilsulfóxido, un éster de alcohol graso (C8-C20) de ácido láctico, un éster de alquilo (C1-C4) inferior de ácido láctico y ácido cáprico, y hormonas que controlan fertilidad que comprenden una combinación de una progestina y un estrógeno.
Patent ES-2252099-T3 (ES)
Inventor: STEUER ARMIN
IPC: B41F19/06
Filed: 2001-02-21
Granted: 2006-05-16
Abstract: The method involves pressing a section of a transfer area onto a bearer material in an embossing station, whereby the transfer area is fed into the embossing station in the form of a continuous foil strip (11). Fault points (28-30) in the foil strip are detected by a sensor (27) as it is being fed to the embossing station and fault points are fed between two embossing in the station. An Independent claim is also included for a relief printer.
Patent ES-2194807-T3 (ES)
Inventor: BOLLINGER THOMAS
IPC: G06T7/262
Filed: 2001-05-04
Granted: 2003-12-01
Abstract: The method involves dividing the digitized images into defined size segments, transforming (4) the segments into the frequency domain, whereby each is transformed into a separate frequency domain representation, comparing (9) the magnitude of a defined frequency component of a segment corresponding to a frequency domain representation for both images and detecting (10) motion if the frequency component magnitude difference exceeds a defined value. AN Independent claim is also included for the following: a camera system for acquiring digitized images.
Patent ES-2269314-T3 (ES)
Title: Cubierta neumatica.
Inventor: ITO TAKAHIRO
IPC: B60C11/11
Filed: 2001-06-21
Granted: 2007-04-01
Abstract: Cubierta neumática que comprende una parte (14) que constituye la banda de rodadura y tiene una pluralidad de tacos (18, 20; 22), teniendo cada uno de dichos tacos al menos una subacanaladura (26) que incluye una parte central principal (26A) y partes extremas (26B) que conectan la parte central principal a una acanaladura circunferencial; estando dicha cubierta neumática caracterizada por el hecho de que la parte central principal (26A) es oblicua con respecto al plano ecuatorial (CL) de la cubierta en una dirección opuesta a la dirección de oblicuidad de cada una de las partes extremas (26B), y de que la parte central principal (26A) de la subacanaladura está formada de forma tal que el fondo (26C) de dicha subacanaladura está inclinado con respecto a la desembocadura de dicha subacanaladura en la parte de la superficie exterior del taco en la dirección del esfuerzo principal que es aplicado desde la superficie de la carretera al taco, y las partes extremas (26B) de la subacanaladura están formadas de forma tal que el fondo de dicha subacanaladura se extiende en sustancia verticalmente con respecto a la superficie exterior del taco.
Patent ES-2248256-T3 (ES)
Inventor: GRUNER CLAUDIUS DIPL-ING
IPC: B60R16/02
Filed: 2001-12-14
Granted: 2006-03-16
Abstract: The support housing is formed from two half shell elements (1,2) that fit together around several cables (3) in a wiring loom. The shells are held together by formed latching elements (4). A curved version of the housing is possible.
Patent ES-2266196-T3 (ES)
Inventor: SCHMID KARL HEINZ
IPC: C11D11/00
Filed: 2001-04-06
Granted: 2007-03-01
Abstract: Surfactant granules are made by the process comprising the steps of (1) mixing an aqueous nonionic surfactant paste and an aqueous solution of an organic polymeric carrier; (2) simultaneously granulating and drying the mixture from step (1) in a fluidized bed to form a granulated nonionic surfactant. The surfactant granules are dust-free, flowable, storage-stable, show no tendency toward clumping and are readily soluble in cold water.
Patent ES-2296764-T3 (ES)
Title: Enlace de prueba de deteccion de descarga parcial. sistema de deteccion de descarga parcial y procedimiento para la deteccion de la descarga parcial en un cable de energia.
Inventor: GREGORY BRIAN
IPC: G01R15/14
Filed: 2001-01-26
Granted: 2008-05-01
Abstract: Conexión de prueba de detección de descarga parcial (20) para detectar la descarga parcial de un cable de energía (18) en una accesorio de cable de energía (6) incluyendo un primer componente de accesorio (8) y un segundo componente de accesorio (10) conectados entre sí, comprendiendo la conexión de prueba de detección de descarga parcial: un elemento conductor (22) que incluye un elemento eléctricamente conductor (26) y un aislante (28) rodeando y extendiéndose a lo largo del elemento eléctricamente conductor, presentando el elemento eléctricamente conductor un par de extremos opuestos (30) con un extremo respectivo adaptado para la conexión eléctrica a un componente respectivo entre el primer y segundo componentes de accesorio (8, 10); y caracterizada por el hecho de que un sensor de descarga parcial (24) está dispuesto alrededor del elemento conductor (22), presentando el sensor de descarga parcial un devanado primario en forma de elemento eléctricamente conductor (26) y un devanado secundario (34), estando dispuesto el aislante (28) entre el devanado primario y el devanado secundario.
Patent ES-2236268-T3 (ES)
Inventor: BIGOTTO PIER CARLO
IPC: H01R13/422
Filed: 2001-06-19
Granted: 2005-07-16
Abstract: An electric connector ( 2 ) having an insulating casing ( 15 ) defining at least two cavities ( 16 ) for housing respective electric terminals ( 17 ); short-circuit means ( 55 ) carried by the casing ( 15 ) and which can be set to a first operating configuration mutually connecting the terminals ( 17 ), and a second operating configuration isolated electrically from the terminals ( 17 ); and a manually operated short-circuit cutoff device ( 61 ) carried by the casing ( 15 ) and which can be activated selectively to move the short-circuit means ( 55 ) from the first to the second operating configuration.
Patent ES-2217169-T3 (ES)
Title: Procedimiento para conservar pasteles y tartas que contienen nata batida.
Inventor: BAUER GERHARD
IPC: A21D15/02
Filed: 2001-07-06
Granted: 2004-11-01
Abstract: Procedimiento para la conservación de productos de repostería, que están fabricados utilizando nata batida, especialmente un pastel o una tarta, caracterizado porque el producto de repostería es introducido en un envase, es refrigerado, el aire contenido en el envase y en la nata batida es substituido a través de intercambio de gas, que se realiza a través de la aspiración del aire y la inundación siguiente con gas protector, a través de un gas protector y a continuación se cierra el envase de forma hermética al aire, pudiendo intercambiarse la secuencia de la introducción en el envase y de la refrigeración.
Patent ES-2295188-T3 (ES)
Title: Accesorio para abertura de bolsa.
Inventor: GROSS RICHARD A
IPC: B65D75/58
Filed: 2001-07-27
Granted: 2008-04-16
Abstract: Un accesorio (10; 110) para ser recibido de forma estanca en una bolsa (20; 120) plegable que tiene dos porciones (22; 122) de membrana flexible, opuestas, selladas cada una con la otra de modo que definen una región (24, 124) interior y de modo que definen una abertura (26), la cual abre hacia la región (24) interior, y la cual está adaptada para recibir el accesorio (10; 110) cuando el accesorio (10; 110) es recibido de forma estanca en la bolsa (20; 120) plegable, disponiendo el accesorio (10; 110) de un cuerpo (30; 130) que tiene al menos una porción (32; 132) de pared lateral, la cual se ha dotado de escalonamientos (50, 52, 54; 150, 152, 154) espaciados que definen resaltos (62, 64, 66, 68; 162, 164, 166, 168) espaciados, teniendo el cuerpo (30; 130) un extremo (34; 134) interno, el cual se enfrenta al interior de la bolsa (20; 120) plegable cuando el accesorio (10; 110) está recibido de forma estanca en la bolsa (20; 120) plegable, disponiendo el cuerpo (30; 130) de un extremo (44; 144) externo y definiendo un plano (PR) de referencia, definiendo el cuerpo (30; 130) una gama de dimensiones periféricas, cada una de las cuales se mide alrededor de uno de los escalonamientos (50, 52, 54; 150, 152, 154) espaciados, o alrededor de uno de los resaltos (62, 64, 66, 68; 162, 164, 166, 168) espaciados, en un plano que se sitúa en uno de los extremos interno y externo o entre los extremos (34, 44; 134, 144) interno y externo y que coincide con el, o es paralelo al, plano de referencia, incrementándose las dimensiones periféricas desde una dimensión más pequeña en, o hacia, un extremo citado, a través de dimensiones intermedias que entre los extremos interno y externo no disminuyen tras el incremento, hasta una dimensión más grande en, o hacia, el otro extremo; incluyendo cada uno de dichos resaltos (62, 64, 66; 152, 164, 166) una superficie (72, 74, 76; 172, 174, 176) de sellado ahusada que es oblicua con respecto a, y que está definida entre, una superficieadyacente de dicha porción (32; 132) de pared lateral y uno adyacente de los citados escalonamientos (50, 52, 54; 150, 152, 154).
Patent ES-2246334-T3 (ES)
Title: Dispositivo y metodo para limpiar y esterilizar un recipiente de alimentos.
Inventor: BAUTISTA DERRICK A
IPC: C11D17/04
Filed: 2001-05-30
Granted: 2006-02-16
Abstract: Un dispositivo para limpiar y esterilizar un recipiente de bebidas o alimentos comprendiendo: - un primer compartimento que contiene un componente de limpieza que incluye por lo menos una o más enzimas en una cantidad suficiente para limpiar el recipiente; y - un segundo compartimento que contiene por lo menos una sustancia antimicrobial en una cantidad suficiente para esterilizar el recipiente en que el primer compartimento y el segundo compartimento están separados por una barrera que se degrada cuando entra en contacto con un medio acuoso y que retrasa el desprendimiento de la sustancia antimicrobial del segundo compartimento hasta que el componente de limpieza ha limpiado el recipiente.
Patent ES-2219551-T3 (ES)
Inventor: KERSCHER ALBERT
IPC: B60T17/22
Filed: 2001-08-10
Granted: 2004-12-01
Abstract: The invention relates to a display device (1) for an emergency release device (2) for spring-loaded brakes (4), especially for rail vehicles. Said display device is used to acknowledge the actual state of the spring-loaded brake (4) for a manually operated activating device (6) pertaining to the emergency release device (2). Said activating device is coupled to the spring-loaded brake (4) by means of a mechanic power transmission element (8). The display device (1) and the activating device (6) are arranged at a distance from the spring-loaded brake (4) and are thus easily accessible. The mechanic power transmission element (8) is also used for the tellback of the information on the actual state of the spring-loaded brake (4), and can furthermore activate the display device (1), enabling a correct and reliable display at all times. The invention also relates to a spring-loaded brake (4) comprising one such display device (1).
Patent ES-2248383-T3 (ES)
Inventor: KESSLER ARND
IPC: C11D3/39
Filed: 2001-06-27
Granted: 2006-03-16
Abstract: The invention relates to a cleaning agent for dishwashers comprising a first part (basic composition), which mainly acts during the main cleaning cycle of the dishwasher, and a second part, which mainly acts during the rinsing cycle of the dishwasher as a result a suitable coating. The second part contains one or several substances form the following group: detergency builders, acidifying agents, chelate complex builders or coating inhibiting polymers.
Patent ES-2269446-T3 (ES)
Title: Benzoil-pirazoles y su utilizacion como herbicidas.
Inventor: SCHMITT MONIKA
IPC: A01H5/00
Filed: 2001-03-17
Granted: 2007-04-01
Abstract: Benzoíl-pirazoles de la fórmula (I) o sus sales en los que R1 significa metilo o etilo; R2 significa trifluorometilo; R3 significa hidrógeno, metilo o etilo; R4 significa metilo, etilo o n-propilo; R5 significa hidrógeno, alquil (C1-C6)-carbonil-metilo, alquil (C1-C4)-sulfonilo, fenil-sulfonilo, bencilo, benzoíl-metilo, alquil (C1-C3)-sulfonilo sustituido una vez o múltiples veces con halógeno, fenil-sulfonilo sustituido una vez con metilo o halógeno, bencilo sustituido con halógeno, nitro o metoxi, o benzoíl-metilo sustituido una vez o múltiples veces con halógeno, nitro, metilo o metoxi, y