Patent SG-11201809841Q-A (SG)
Title: Bacillus coagulans mtcc 5856 for the management of major depressive disorder
Inventor: NAGABHUSHANAM KALYANAM
IPC: C12N1/20
Filed: 2016-06-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11011110111010101111101 110100111101110111111011110111011110 1111 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/004586 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, A61K 35/742 (2015.01) Cl 2N 1/20 (2006.01) HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, (21) International Application Number: LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, PCT/US2016/040290 MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, (22) International Filing Date: SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, 30 June 2016 (30.06.2016) UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors; and UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants: MAJEED, Muhammed [US/US]; Sabinsa TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Corporaton, 20 Lake Drive, East Windsor, NJ 08520 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (US). NAGABHUSHANAM, Kalyanam [US/US]; Sabin- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, sa Corporation, 20 Lake Drive, East Windor, NJ 08520 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (US). ARUMUGAM, Sivakumar [IN/IN]; Sami Labs KM, ML, MR, NE, SN, TD, TG). Limited, 19/2 & 19/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560058 (IN). ALI, Furgan [IN/IN]; Sami Published: Labs Limited, 19/2 & 19/2, I Main, II Phase, Peenya Indus- — with international search report (Art. 21(3)) _ trial Area, Bangalore 560058 (IN). — with amended claims (Art. 19(1)) — with (an) indication(s) in relation to deposited biological NAGABHUSHANAM, material furnished under Rule 13bis separately from the (74) Common Representative: = 20 Lake Drive, East Kalyanam; Sabinsa Corporation, description (Rules 13bis.4(d)(i) and 48.2 (a)(viii)) _ NJ 08520 (US). = Windsor, indicated, for every (81) Designated States (unless otherwise kind AE, AG, AL, AM, of national protection available): BH, BN, BR, BW, BY, BZ, = AO, AT, AU, AZ, BA, BB, BG, CZ, DE, DK, DM, DO, DZ, CA, CH, CL, CN, CO, CR, CU, = MTCC 5856 FOR THE MANAGEMENT OF MAJOR DEPRESSIVE DISORDER (54) Title: BACILLUS COAGULANS = = = Fig. 2a = = A la = 106 = — 0 = 14 eti = — 04 _ 12 • = A *J\" 10 - -1' 8 = 1-1 1 4 4 . a i.,. 2 - GC In Wselttie .10 t ays 60 days 90 di):* % (t•od of 71' the study) 0 ill Placebo 013. coming MCC 5856 --.... 00 1-1 N (57) : The present invention discloses the use of probiotics for therapeutic management of major depressive disorder (MDD). Specifically, the invention discloses the method of therapeutically managing MDD in mammals with Irritable bowel syndrome using C probiotic strain Bacillus coagulans MTCC 5856.