Patent SG-11201908422Y-A (SG)
Title: Glycopolymers sequestering carbohydrate-binding proteins
Inventor: PFISTER HÉLÈNE BLANCHE
IPC: C07H15/12
Filed: 2018-03-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT Hu omit VIII °nolo omioomi 011111mo ow (10) International Publication Number WO 2018/167230 Al (51) International Patent Classification: A61K 47/64 (2017.01) C07H 15/203 (2006.01) CO7H 15/04 (2006.01) A61P 31/04 (2006.01) CO7H 15/12 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/EP2018/056583 (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17161162.7 15 March 2017 (15.03.2017) EP (71) Applicant: POLYNEURON PHARMACEUTICALS AG [CH/CH]; Hochbergerstrasse 60c, 4057 Basel (CH). (72) Inventors: PFISTER, Helene Blanche; Missionsstr. 8, 4055 Basel (CH). HERRENDORFF, Ruben; St. Jo- hanns-Vorstadt 47, 4056 Basel (CH). ERNST, Beat; Hohenweg 1, 4312 Magden (CH). (74) Agent: SPERRLE, Martin; Latscha Schollhorn Partner AG Austrasse 24, 4051 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: with international search report (Art. 21(3)) 1-1 • (54) Title: GLYCOPOLYMERS SEQUESTERING CARBOHYDRATE-BINDING PROTEINS 0 (57) : The invention relates to polymers comprising carbohydrate ligands and moieties, respectively, that bind to carbohy- drate-binding proteins (CBPs), as well as to these carbohydrate ligands, and to their use in diagnosis and therapy of diseases that are N associated with CBP-mediated cytotoxicity, agglutinatination, or immune complex deposit formation. In particular, the invention relates to polymers comprising a multitude of said carbohydrate ligands and moieties, respectively, mimicking carbohydrates that are bound by 1-1 ▪ CBPs which belong to the group of (i) bacterial exotoxins, (ii) agglutinins, and (iii) immune complex deposit-forming immunoglobu- lins. Furthermore, the invention relates to the use of these polymers and carbohydrate ligands and moieties respectively, in diagnosis as O 1-1 well as for the treatment of diseases that are associated with CBP-mediated cytotoxicity, agglutinatination, or immune complex deposit N formation. In one embodiment, the polymer is polylysine.