Patent SG-11201902529W-A (SG)
Title: Naphthyridinone derivatives and their use in the treatment of arrhythmia
Inventor: BARBE GUILLAUME
IPC: A61K31/4375
Filed: 2017-10-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 0 11101 HOE 3E1 0 0111E1111001 HE ME 110 11110 1111 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/073788 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: gin; Novartis Institutes for BioMedical Research, Inc., CO7D 471/04 (2006.01) A61P 9/06 (2006.01) 250 Massachusetts Avenue, Cambridge, MA 02139 (US). A61K 31/4375 (2006.01) LIAO, Lv; Shanghai Novartis Trading Ltd., 4218 Jinke (21) International Application Number: Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203 (CN). MA, Fupeng; Novartis Institutes for BioMedical Re- PCT/IB2017/056515 search, Inc., 250 Massachusetts Avenue, Cambridge, MA (22) International Filing Date: 02139 (US). MO, Ruowei; Novartis Institutes for BioMed- 19 October 2017 (19.10.2017) ical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139 (US). PARKER, David Thomas; 25 Crestwood (25) Filing Language: English Road, Windham, NH 03087 (US). PENG, Yunshan; No- (26) Publication Language: English vartis Institutes for Biomedical Research, Inc., 250 Mass- achusetts Avenue, Cambridge, MA 02139 (US). PEUK- (30) Priority Data: ERT, Stefan; Novartis Institutes for Biomedical Research, PCT/CN2016/102928 Inc., 250 Massachusetts Avenue, Cambridge, MA 02139 21 October 2016 (21.10.2016) CN (US). YAMADA, Ken; Novartis Institutes for Biomed- 62/410,930 21 October 2016 (21.10.2016) US ical Research, Inc., 250 Massachusetts Avenue, Cambridge, 62/413,292 26 October 2016 (26.10.2016) US MA 02139 (US). YASOSHIMA, Kayo; Novartis Institutes (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, for Biomedical Research, Inc., 250 Massachusetts Avenue, 4056 Basel (CH). Cambridge, MA 02139 (US). (72) Inventors: BARBE, Guillaume; 583 Pleasant Street, Mil- (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4056 Basel ton, MA 02186 (US). BEBERNITZ, Gregory Raymond; (CH). _ 799 Bartlett Carry Road, Tupper Lake, NY 12986 (US). (81) Designated States (unless otherwise indicated, for every = GENG, Sicong; Jinke Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai Shanghai Novartis Trading Ltd., 4218 kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, _ 201203 (CN). CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, GULGEZE EFTHYMIOU, Hatice Bel- CA, (54) Title: NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA (57) : The present invention provides a compound of formu- = = ElgUre 1. PCIRP0.0 example 1 11Yd.R 1 0 X.R. e la (I) or a pharmaceutically acceptable salt thereof; (I) Wherein R 1 , R 3 -R 6 , X 2 and X 3 are as defined herein, a method for manufacturing = the compounds of the invention, and its therapeutic uses. The present i invention further provides a combination of pharmacologically active = = agents and a pharmaceutical composition. I = _ = = h = = _ _ = — Il GC CI 11 0 R s GC R° IN en N R' IN I 1 1 © ,-.... x ,...,„. 11 Fe 0 (I) © N O [Continued on next page] WO 2018/073788 Al MIDEDIMOMOIDEIREEMOOMEIIIIIIIIMOMEEN DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))