baber/WOPTO huggingface dataset:
Patent CA-3136842-A1 (CA)
Title: Production of salipro particles
Inventor: LOVING ROBIN
IPC: A61K47/42
Filed: 2020-04-15
Abstract: The invention relates to a process for preparing saposin lipoprotein particles, comprising a saposin-like protein, lipids and optionally a hydrophobic agent wherein the saposin-like protein or the hydrophobic agent is selectively bound to a support to allow the self-assembly of the saposin lipoprotein particles. The process of the invention comprises the step of a.) providing the hydrophobic agent and lipids, b. 1)/b.2) contacting the hydrophobic agent or the saposin-like protein with a support that is capable of selectively binding either of the two molecules to the support, c.1)/c.2) contacting the support-bound particle components with the remaining particle components, either the saposin-like protein or the hydrophobic agent, to allow fpr the self-assembly of the saposin lipoprotein particle on the support and d.) optionally eluting the support-bound saposin lipoprotein particles.
Patent CA-3138679-A1 (CA)
Inventor: HASSANPOUR SAEED
IPC: G06T7/00
Filed: 2020-04-08
Abstract: This invention provides a system and method for analyzing and classifying imaged from whole slides of tissue. A source of image data transmits images of the tissue on the whole slides to a GPU. The GPU performs a feature extraction process that identifies and segments regions of interests in each of the images, and an attention network that, based upon training from an expert, identifies trained characteristics can comprise cancerous and/or pre-cancerous conditions/e.g. those associated with a gastrointestinal tract, such ad Barret's Esophagus. The feature extraction process can include a convolutional neural network (CNN). The attention network can be adapted performs attention/based weighting of features relative to the trained characteristics, and/or the attention network can include 3D convolutional filters. The image data is acquired using an image sensor having approximately 100 Megapixel resolution.
Patent CA-3139104-A1 (CA)
Title: Thiosemicarbazates and uses thereof
Inventor: AL-ABED YOUSEF
IPC: C07D279/00
Filed: 2020-05-08
Abstract: Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.
Patent CA-3139156-A1 (CA)
Inventor: BANNEN LYNNE CANNE
IPC: C07D487/04
Filed: 2020-06-03
Abstract: L'invention concerne des composés de formule (I) qui inhibent, régulent et/ou modulent des récepteurs de tyrosine kinase, en particulier des voies de transduction de signal Axl et Mer associées aux changements d'activités cellulaires, des compositions contenant les composés, des méthodes d'utilisation des composés pour traiter des maladies et des états dépendant de la kinase, et des procédés de fabrication des composés.
Patent CA-3139328-A1 (CA)
Title: Attenuated yellow fever virus and uses thereof for the treatment of cancer
Inventor: COLEMAN JOHN ROBERT
IPC: A61K39/385
Filed: 2020-05-14
Abstract: The present invention is the use of designed recombinant viruses for the treatment of various forms of malignant tumors using attenuated Yellow Fever virus. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of treatment of breast cancer and melanoma.
Patent CA-3139550-A1 (CA)
Inventor: FAN KAI
IPC: A61K47/56
Filed: 2020-05-08
Abstract: L'invention concerne une urate oxydase modifiée par du polyéthylène glycol. L'urate oxydase contient des modifications de PEG au niveau d'au moins onze des sites d'acides aminés suivants : T 1, K 3, K 4, K 30, K 35, K 76, K 79, K 97, K 112, K 116, K 120, K 152, K 179, K 222, K 231, K 266, K 272, K 285, K 291, et K 293.
Patent CA-3140355-A1 (CA)
Title: Ski strap assembly and hanging device for ski strap
Inventor: KEOHANE MARK EDMUND
IPC: A63C11/02
Filed: 2018-03-16
Abstract: The following describes an assembly for a ski strap. The assembly comprises a first portion comprising a first outer block, a first inner tab extending from the first outer block, a first retaining mechanism for a strap. The assembly also comprises a second portion comprising a second outer block, a second inner tab extending from the second outer block, and a second retaining mechanism for the strap. A ski strap assembly is also provided that comprises a ski strap and the assembly.
Patent CA-3147153-A1 (CA)
Title: Key export techniques
Inventor: CAMPAGNA MATTHEW JOHN
IPC: G06F21/62
Filed: 2016-03-25
Abstract: A computer system performs cryptographic operations as a service. The computer system is configured to allow users of the service to maintain control of their respective cryptographic material. The computer system uses inaccessible cryptographic material to encrypt a user's cryptographic material in a token that is then provided to the user. The user is unable to access a plaintext copy of the cryptographic material in the token, but can provide the token back to the service to cause the service to decrypt and use the cryptographic material.
Patent CA-3147821-A1 (CA)
Title: Process for preparing alkali metal alkoxides in a three-chamber electrolysis cell
Inventor: REINSBERG PHILIP HEINRICH
IPC: C25B1/04
Filed: 2022-02-04
Abstract: The present invention relates to a process for electrochemical preparation of an alkali metal alkoxide solution. The process is performed in an electrolysis cell having three chambers, wherein the middle chamber is separated from the cathode chamber by a solid-state electrolyte permeable to cations, for example NaSICON, and from the anode chamber by a diffusion barrier, for example a membrane selective for cations or anions. The process according to the invention solves the problem that a concentration gradient forms in the middle chamber of the electrolysis cell during the electrolysis, which leads to locally lowered pH values and hence to damage to the solid-state electrolyte used. This is prevented in that a gas is introduced into the middle chamber during the electrolysis, which results in better mixing of the electrolyte solution in the middle chamber and hence prevents the formation of a concentration gradient.
Patent CA-3154208-A1 (CA)
Title: Audio management for guests
Inventor: FRY DARRIN KENNETH JOHN
IPC: H04R29/00
Filed: 2022-04-05
Abstract: In some examples, a control audio management engine is configured to interact with guest audio services in respective guests that have different audio management capabilities. The control audio management engine receives an indication of a start of a first audio in a first guest of the guests, the indication comprising an audio stream. The control audio management engine sends, to a second guest of the guests, control information to affect playback of a second audio that is playing in the second guest.
Patent CA-3157328-A1 (CA)
Inventor: MAULETTI ENRICO
IPC: B62D61/00
Filed: 2020-10-19
Abstract: Système mobile autonome (100) utilisé dans une installation industrielle comme un système opérateur mobile, apte à être facilement reconfiguré en fonction des besoins de chaque application spécifique. Le système (100) comprend un véhicule autonome (1), sous la forme d'un robot mobile autonome, et un chariot de transport (10) configuré pour recevoir une charge sur celui-ci, devant être transportée, et/ou une ou plusieurs unités opérationnelles (12). Le véhicule autonome (1) est configuré pour être positionné de manière adjacente au chariot (10), et comprend un dispositif de couplage (5), qui peut être déplacé pour accoupler le chariot (10) au véhicule autonome (1), de telle sorte que le véhicule autonome (1) est apte à déplacer le chariot (10) le long d'un trajet, tandis que le poids de la charge portée sur le chariot (10) repose uniquement sur le chariot (10). Le chariot est configuré pour porter une ou plusieurs unités opérationnelles (12) commandées par un ou plusieurs dispositifs de commande électroniques, disposés au moins en partie sur le véhicule autonome (1). Le véhicule autonome est par conséquent le cerveau qui commande également les dispositifs à bord du chariot. Le dispositif de couplage (5) comprend un dispositif formant connecteur électrique (53, 54) pour effectuer une connexion entre les unités opérationnelles (12) portées par le chariot (10) et un ou plusieurs dispositifs de commande électroniques (E) portés par le véhicule autonome (1).
Patent CA-3157441-A1 (CA)
Inventor: PAMPLIN KIM
IPC: B05B17/06
Filed: 2020-11-06
Abstract: Apparatus, systems, and methods for identifying and quantifying chemical components in a high-melting-point liquid. One such method includes: receiving, into a nebulizer assembly, a high-melting-point liquid from a molten liquid conduit; aerosolizing, using the nebulizer assembly, at least a portion of the received high-melting-point liquid; delivering, into one or more instruments, the aerosolized high-melting-point liquid from the nebulizer; and chemically analyzing, using the one or more instruments, the aerosolized high-melting-point liquid.
Patent CA-3157496-A1 (CA)
Title: Compositions de fibres alimentaires avec du psyllium et procedes d'utilisation
Inventor: GAHLER ROLAND JACQUES
IPC: A23L29/256
Filed: 2020-11-12
Abstract: Composition alimentaire comprenant (i) d'environ 40 % à environ 80 % (poids/poids) d'une composition fibreuse comprenant du glucomannane, de la gomme xanthane et de l'alginate ; et (ii) d'environ 10 % à environ 60 % (poids/poids) du psyllium est fourni, ainsi qu'un procédé et un produit alimentaire pour favoriser la satiété, favoriser la perte de poids, abaisser les taux de cholestérol dans le sang ou abaisser les taux de glucose dans le sang chez un mammifère.
Patent CA-3158007-A1 (CA)
Title: Rail contact element and drop off detection unit
Inventor: GEBERT THOMAS
IPC: B61L1/02
Filed: 2020-12-11
Abstract: The invention concerns a rail contact element (10, 10a, 10b, 10c, 10d, 10e, 10f, 10g) for drop off detection, wherein the rail contact element (10, 10a, 10b, 10c, 10d, 10e, 10f, 10g) is mountable to a rail (12) and comprises a spring element (14), a main body (16) which holds the spring element and an optical fibre (18), wherein the spring element (14) is in a tension state or in a relax state depending on a mounting state of the rail contact element. The optical fibre (18) comprises an outlet surface (20) for emitting a light beam (22) and the rail contact element (10, 10a, 10b, 10c, 10d, 10e, 10f, 10g) further comprises a reflector element (24). The spring element (14), the reflector element (24) and the optical fibre (18) are arranged so that the influence of the reflector element (24) on the light beam (22) is different in the tension state than in the relax state.
Patent CA-3158529-A1 (CA)
Inventor: REINHARD GUNTHER
IPC: A47G29/12
Filed: 2022-05-05
Abstract: The invention relates to a parcel chute (1) for an outer wall (13) of a building or an enclosure of a balcony which is used for the automatic delivery and collection of a parcel (2) by means of an unmanned aircraft, in particular a logistics drone; a method for delivering a parcel (2) using an unmanned aircraft, in particular a logistics drone; an outer wall (13) with a parcel chute (1); and an enclosure with a parcel chute (1).
Patent CA-3159325-A1 (CA)
Inventor: WALDHART MICHAEL
IPC: F02D41/00
Filed: 2019-12-23
Abstract: L'invention concerne un système comprenant - une grille de distribution (2) destinée à un combustible, - des moteurs à combustion (3), accouplés à la grille de distribution (2) et conçus pour faire brûler le combustible, et - un système informatique (4) comprenant des connexions de données (5) aux moteurs à combustion (3) et un dispositif de stockage de données (6). Le système informatique (4) est configuré pour recevoir des paramètres d'opération de moteurs liés à une opération des moteurs à combustion (3) à un premier instant et/ou pendant une première durée, par l'intermédiaire des connexions de données (5), tandis que des données géographiques des moteurs à combustion (3) sont mémorisées dans le dispositif de stockage de données (6). Le système informatique (4) comporte un processeur (7) configuré pour calculer une prédiction pour au moins un paramètre caractéristique du combustible à un second instant et/ou pendant une seconde durée postérieure au premier instant et/ou à la première durée et par rapport à un emplacement géographique, tandis que le calcul de la prédiction est basé sur les données géographiques et sur les paramètres d'opération de moteurs des moteurs à combustion (3).
Patent CA-3159835-A1 (CA)
Title: 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds and their therapeutic use
Inventor: AINSCOW EDWARD
IPC: C07D487/04
Filed: 2020-12-16
Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain H-APPAMP compounds (referred to herein as "H-APPAMP compounds") that, inter alia, inhibit cyclin-dependent protein kinases (CDKs), especially CDK12 and/or CDK13, and are selective, for example, for CDK12 and/or CDK13 as compared to CDK7. In addition to selectively inhibiting CDK12 and/or CDK13, the compounds also act as selective Cyclin K degraders thereby removing the key signaling mechanism required for CDK12 and/or CDK13 activation; this confers additional cellular potency and selectivity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CDK, especially CDK12 and/or CDK13; and to treat disorders including: disorders that are associated with CDK, especially CDK12 and/or CDK13; disorders that result from an inappropriate activity of a CDK, especially CDK12 and/or CDK13; disorders that are associated with CDK mutation, especially CDK12 and/or CDK13mutation; disorders that are associated with CDK overexpression, especially CDK12 and/or CDK13 overexpression; disorders that are associated with upstream pathway activation of CDK, especially CDK12 and/or CDK13; disorders that are ameliorated by the inhibition of CDK, especially CDK12 and/or CDK13; proliferative disorders; cancer; viral infections (including HIV); neurodegenerative disorders (including Alzheimer's disease and Parkinson's disease); ischaemia; renal diseases; cardiovascular disorders (including atherosclerosis); autoimmune disorders (including rheumatoid arthritis); and disorders caused by dysfunction of translation in cells (including muscular dystrophy). Optionally, the treatment further comprises treatment (e.g., simultaneous or sequential treatment) with a further active agent which is, e.g., an aromatase inhibitor, an anti estrogen, an anti-androgen, a Her2 blocker, a cytotoxic chemotherapeutic agent, an agent stimulating the immune system, a checkpoint inhibitor, a DMA repair inhibitor, etc.
Patent CA-3160739-A1 (CA)
Title: Methodes et compositions d'arn circulaire
Inventor: GOODMAN BRIAN
IPC: C12N15/64
Filed: 2020-12-04
Abstract: L'invention concerne des ARN circulaires et des véhicules de transfert, ainsi que des compositions et des méthodes de traitement associés. Les ARN circulaires peuvent comprendre des fragments d'introns du groupe I, des espaceurs, un IRES, des régions de formation de duplex et/ou une séquence d'expression, présentant ainsi les caractéristiques d'expression améliorée, de stabilité fonctionnelle, de faible immunogénicité, de facilité de fabrication et/ou de demi-vie étendue par rapport à l'ARN linéaire. Des compositions pharmaceutiques comprenant de tels ARN circulaires et véhicules de transfert sont particulièrement appropriées pour une expression de protéine efficace dans des cellules immunitaires in vivo. L'invention concerne également des ARN précurseurs et des matériaux utiles dans la production des ARN précurseurs ou circulaires, qui ont une efficacité de circularisation améliorée et/ou sont compatibles avec des méthodes de purification d'ARN circulaire efficaces.
Patent CA-3163558-A1 (CA)
Inventor: AUSTRHEIM TROND
IPC: B65G1/04
Filed: 2020-11-18
Abstract: A remotely operated vehicle (401,501) comprising a first set of wheels (401b, 501b) comprising a first pair of wheels (10) and a second pair of wheels (11), allowing movement of the vehicle (401,501) along a first direction (X); a second set of wheels (401c, 501c) comprising a third pair of wheels (13) and a fourth pair of wheels (14), allowing movement of the vehicle (401,501) along a second direction (Y) being perpendicular to the first direction (X); a wheel displacement assembly (15) arranged to move the second set of wheels (401c, 501c) in a vertical direction (Z); and a wheel drive assembly comprising a first motor (16), a drive band (18) and a band drive wheel (17), and the drive band (18) interconnecting the band drive wheel and the third pair of wheels (13), wherein the third pair of wheels (13) and the first motor (16) are mounted to a cross-plate (23) arranged to move vertically as part of the wheel displacement assembly, such that the cross-plate supports the third pair of wheels (13) and the band drive wheel (17) in a fixed spatial configuration where each wheel of the third pair of wheels (13) is located at an end portion of the cross-plate (23) and the band drive wheel (17) is positioned at a central portion of the cross-plate (23).
Patent CA-3165020-A1 (CA)
Inventor: PANANDIKER RAJAN KESHAV
IPC: C11D17/00
Filed: 2021-02-03
Abstract: Silicone/perfume emulsion compositions that include an aminofunctional silicone, one or more emulsifiers, one or more perfume raw materials, and water. Consumer products that include such emulsion compositions. Related methods of making and using such emulsions and consumer products.
Patent CA-3169459-A1 (CA)
Inventor: KALIDINDI SANYASI
IPC: A61K36/73
Filed: 2021-03-04
Abstract: The present invention is directed to methods of treating cancer and inhibiting proliferation of cancer cells with compositions comprising extracts prepared from Terminalia chebula fruits (for instance AyuFlex®), Terminalia bellerica fruits (for instance Ayuric®), Phyllanthus emblica fruits (for instance Capros®), Withania somnifera roots and leaves (for instance Sensoril®), Shilajit (for instance PrimaVie®), Azadirachtaindica leaves and twigs (for instance PhytoBGS®), and/or combinations thereof, including a trivalent chromium complex with extracts of Shilajit and P. emblica (e.g. Crominex-3+®). Combinations of the extracts with anti-cancer drugs, and related methods, are also described.
Patent CA-3170118-A1 (CA)
Inventor: TAUNTON JOHN
IPC: C07D471/04
Filed: 2021-02-05
Abstract: L'invention concerne, entre autres, des composés permettant d'inhiber le facteur d'allongement 1-alpha et leurs utilisations.
Patent CA-3171052-A1 (CA)
Inventor: BELHAJ NABILA
IPC: A61K8/60
Filed: 2021-03-09
Abstract: La présente invention concerne une composition hautement purifiée comprenant un oligosaccharide de mannose, ainsi qu'un procédé de fabrication associé. La présente invention concerne également l'utilisation d'une composition hautement purifiée comprenant un oligosaccharide de mannose pour stimuler la production de collagène I, de collagène III et/ou de fibrilline 1 dans la peau d'un mammifère.
Patent CA-3172580-A1 (CA)
Title: A cybersecurity system to manage security of a computing environment (ce)
Inventor: D'SOUZA RICHARD
Filed: 2022-09-07
Abstract: The present invention relates management of security of a computing environment. The method may include; monitoring and learning, through a master computer, a data traffic of the each of the coupled connecting node to alter a security design to speed up the communications; analysing, through the master computer, the data traffic to categorize the each of the coupled connecting node into a first category of node, which is accessed by a human and a second category of node, which is accessed by a loot; utilizing, at the master computer, one or more secured hidden servers for determining a first data communication route to speed up data traffic for the human and a second data communication route to prevent data traffic above a pre-set limit, for the bot.
Patent CA-3173046-A1 (CA)
Inventor: SKUTNIK BOLESH J
IPC: G02B6/14
Filed: 2021-02-25
Abstract: A new type of all-silica optical fiber is described; a Structured Silica Clad Silica (SSCS) optical fiber, whose cladding is structured to provide mode mixing within the core; and/or to have an average effective refractive index. Its cross-section is essentially symmetrical, it can be used, among other objects, to provide flatter, more speckle-free outputs from fiber lasers, or other limited mode photonic sources. Building the new fiber structure around a rare earth doped laser core provides a better fiber laser/amplifier for cladding pumping. The structured silica cladding contains paired layers, in which a down doped silica layer is followed by a layer of pure, or lesser down-doped, or even up-dope silica, and die number of paired layers is, typically, from 5 to about 25, and, generally, within the paired layers the ratio of thickness of the higher RI layer of silicate the down-doped silica is very broad, lying between about 0.0625 to about 16, depending on the intended use of the SSCS fibers. In some versions, the main core material can be up-doped silica with pure silica or down-doped silica as the primary second component.
Patent CA-3174046-A1 (CA)
Inventor: Bojaxhi Violeta
IPC: B65D30/04
Filed: 2020-03-02
Abstract: A cotton-based single use grocery bag for carrying groceries or other items. The single use grocery bag is also used for cleaning furniture, cleaning counter tops, washing dishes, etc.
Patent CA-3174348-A1 (CA)
Inventor: GYORY JOHN RICHARD
IPC: A61M5/175
Filed: 2021-03-31
Abstract: A pump for the pumping small volumes of medical fluid is provided. The pump has a manifold chamber having an inlet port and an outlet port. Within the manifold chamber, a cannula having input and output holes oriented with respect to the inlet and outlet ports is rotated within the manifold chamber, and translated axially in a reciprocating manner. The input opening of the cannula overlaps with the inlet port as the manifold chamber volume is increasing to draw fluid into the manifold chamber from the input port. The output opening of the cannula chamber overlaps with the output port as the manifold chamber volume is decreasing to force fluid out of the manifold chamber to the outlet port. The cannula may be formed from metal needle stock.