Patent SG-11201903628T-A (SG)
Title: Hyperpolarized [3- 13c]acetoacetate and methods of using the same
Inventor: LEE TECK HOCK
IPC: A61K49/10
Filed: 2017-10-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date ill Hu omits 1E1 0 0111111 EMI DOI IMMO 011 (10) International Publication Number WO 2018/080394 Al 03 May 2018 (03.05.2018) WIP0 I PCT (51) International Patent Classification: A61K 49/10 (2006.01) (21) International Application Number: PCT/SG2017/050518 (22) International Filing Date: 16 October 2017 (16.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201609057Q 28 October 2016 (28.10.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventor: LEE, Teck Hock; c/o Singapore Bioimaging Consortium, 11 Biopolis Way, #02-02, Singapore 138667 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 1-1 71. (54) Title: HYPERPOLARIZED [3- 13 C]ACETOACETATE AND METHODS OF USING THE SAME 01 (57) : The present invention relates to hyperpolarized [3- 13 C]acetoacetate. Provided are [3- C]acetoacetate and compositions 13 GP comprising said [3- C]acetoacetate. Further provided are methods of preparing and using hyperpolarized [3- C]acetoacetate in the 13 13 determination of the spatial and temporal distribution and metabolism of [3- C]acetoacetate and/or its metabolites in a cell or subject, 13 *t preferably by magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and/or magnetic resonance spectroscopic 1-1 cz imaging (MRSI), whereby conditions, diseases, or disorders associated with the metabolism of acetoacetate and/or other ketone bodies ei can be diagnosed. The conditions, diseases, or disorders to be diagnosed preferably are cancer, diabetes, cardiovascular diseases, or 0 neurodegenerative diseases.