Patent CA-3078765-A1 (CA)
Inventor: LONDESBROUGH DEREK JOHN
IPC: A61P25/00
Filed: 2018-10-09
Abstract: CA 03078765 2020-04-08 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111 111111111 111111 111 11111 1111 11111 1 11 1111 11111 1111 111 11111 1111 11111111111 1111111 International Bureau (10) International Publication Number (43) International Publication Date WO 2019/073379 Al 18 April 2019 (18.04.2019) WIPO I PCT (51) International Patent Classification: Durham TS21 2JB (GB). PATIL, Hemant; c/o Aesi-CO7D 209/16 (2006.01) ca Pharmaceuticals Ltd, North Road, Queenborough Kent ME11 5EL (GB). NICHOLS, David; 56'702 Nash, Chapel (21) International Application Number: Hill, NC NC27517 (US). PCT/IB2018/057811 (74) Agent: EQUIPPED 4 (IP) LIMITED; 4'7 Hamilton (22) International Filing Date: Square, Birkenhead Merseyside CH41 5AR (GB). 09 October 2018 (09.10.2018) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 1716505.1 09 October 2017 (09.10.2017) GB HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 1810588.2 28 June 2018 (28.06.2018) GB KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 1816438.4 09 October 2018 (09.10.2018) GB MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: COMPASS PATHWAYS LIMITED OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, [GB/GB]; 16 Old Bailey, London Greater London EC4M SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 7EG (GB). TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: LONDESBROUGH, Derek John; 3'7 Linden (84) Designated States (unless otherwise indicated, for every Grove, Hartlepool Durham T526 9QA (GB). BROWN, kind of regional protection available): ARIPO (BW, GH, Christopher; 30 Cherrytree Gardens, Gateshead Tyne and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Wear NE9 6TY (GB). NORTHEN, Julian Scott; 36 Hep- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, scat Terrace, South Shields Tyne and Wear NE33 4TH TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (GB). MOORE, Gillian; 22 Matfen Court, Sedgefield EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, = (54) Title: PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS = AND THEIR USE FIG 7A og.sx 'augtoN _______________________________________________________________________ 310 Rat ¨ = lea ¨ A k= 4' , A=A Ir.*" ' ________________________________________ fl' Pom. Pfteui tom:40 fc.13 (57) Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the " manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin. [Continued on next page] CA 03078765 2020-04-08 WO 2019/073379 Al HIM l0llll l llll 11111 11111 3E1111 11111111111111111111 1111111111 1101111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: ¨ as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) ¨ as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: ¨ with international search report (Art. 21(3)) ¨ before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) ¨ in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE