baber/WOPTO huggingface dataset:
Patent DK-1340757-T3 (DK)
Inventor: KOBAYASHI YOSHIYUKI
IPC: A61K31/403
Filed: 2001-11-14
Granted: 2007-02-12
Abstract: The present invention relates to 1-methylcarbapenem compounds having excellent antibacterial activity, pharmacologically acceptable ester derivatives thereof, pharmacologically acceptable salts thereof, pharmaceutical compositions (particularly antibacterial agents) containing them as active ingredient, use of the compounds, ester derivatives or salts thereof for preparing such pharmaceutical compositions and a method of preventing or treating diseases (particularly bacterial infections) in which a pharmacologically effective amount of the compound, ester derivative or salt is administered to a warm-blooded animal (particularly a human being). The 1-methylcarbapenem compounds of the present invention are represented by the general formula (I): <CHEM>  wherein:   R<1> is a group represented by the formula COOR<3> (wherein R<3> represents a hydrogen atom, a C1-C6 alkyl group or the like), a group represented by the formula CONR<4>R<5> (wherein R<4> and R<5> each independently represent a hydrogen atom, a C1-C6 alkyl group which may be substituted or the like), a cyano group, a group represented by the formula CH2OR<6> (wherein R<6> represents a hydrogen atom, a C1-C6 alkyl group or the like) or a group represented by the formula CH2NR<7>R<8> (wherein R<7> represents a hydrogen atom, a C1-C6 alkyl group or the like, and R<8> represents a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkanoyl group, a C1- C6 alkoxycarbonyl group or the like);   R<2> represents a hydrogen atom or a C1-C6 alkyl group;   n represents 1, 2 or 3; and X represents a sulfur atom or an oxygen atom.
Patent DK-1264597-T3 (DK)
Inventor: D AMATO ROBERT
IPC: A61K31/404
Filed: 1994-02-24
Granted: 2006-01-16
Abstract: Thalidomide for treating solid and blood-borne tumours, wherein said tumour is a breast cancer, leukaemia, neoplastic disease of the bone marrow, Kaposi's sarcoma, hemangioma, rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, osteosarcoma, acoustic neuroma, neurofibroma, trachoma, or pyogenic granuloma;and for treating ocular neovascular disease, macular degeneration, proliferative vitreoretinopathy, retrolental fibroplasia, psoriasis, Crohn's disease, diabetic retinopathy, Osler-Weber-Rendu disease, hereditary hemorrhagic telangienctasia or osteoarthritis.
Patent DK-1323648-T3 (DK)
Inventor: GARBAGNATI CARLO
IPC: B65G17/08
Filed: 2002-12-16
Granted: 2005-03-07
Abstract: A chain conveyor link (10) pressed in plastic material comprises a plate (11) defining on top a conveyance surface (12) of the conveyor.   Near the front and rear edges of the link there are seats (15,16) for hinging the link to the other similar links of the chain. Below the plate (11) but spaced therefrom is at least one longitudinal rib (18) extending between the hinging seats (15,16). The space (19) created between the plate and the rib allows better flatness both static and dynamic of the conveyance surface (12). <IMAGE>
Patent DK-1239239-T3 (DK)
Inventor: PIRA LUC
IPC: F25B21/02
Filed: 1997-11-04
Granted: 2006-03-20
Abstract: An apparatus is described which is suitable for thermal treatment of the human or animal skin and underlying tissue, substituting ice frictions, and cold sprays. This cryoprobe is characterised by a Peltier module (22) with a cold and a hot side. An electrical power supply (34) drives the Peltier module (22). The cold side is mounted at a cooling head (23), by which the skin is treated, whereas the hot side is cooled by a heat dissipation element (24) which is itself cooled by a cooling fluid. A temperature sensor (31) in the cooling head (23) allows to control the temperature of treatment. The cryoprobe may be controlled by a micro-controller (30b) or by a personal computer. <IMAGE>
Patent DK-1388260-T3 (DK)
Inventor: LUPO STEPHEN
IPC: G06Q30/06
Filed: 2002-04-03
Granted: 2006-10-16
Abstract: An interactive media response processing system having a plurality of components logically distributed and employing non-relational databases is disclosed, where the response processing system receives interactive response requests from subscribers through set top boxes or other access devices and can process the responses in real time, to provide real time feedback to content producers. The system includes one or more collectors operably connected to one or more aggregators for collecting and aggregating interactive response information, and at least one communications message server connected to each network of subscribers. The communications message server normalizes the responses for each network for transmission to the collectors and aggregators. This system enables subscribers to participate in interactive broadcasts and view response replies in the form of updated interactive content in real time on their television screens or other displays.
Patent DK-1399744-T3 (DK)
Inventor: BUIST ARJAN
IPC: A61P25/04
Filed: 2002-06-26
Granted: 2008-09-22
Abstract: The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.
Patent DK-1415382-T3 (DK)
Inventor: LE FLEM GRAHAM DEREK
IPC: B63H21/17
Filed: 2002-07-29
Granted: 2010-11-29
Abstract: A propulsion unit arranged to propel a water borne vessel comprising an electric motor, arranged to provide propulsion, and a housing (4), arranged to contain the motor, the interior of the housing (4) being maintained at an increased pressure of above roughly 2 bar to increase the cooling effect of a cooling gas maintained therein. Further, it is disclosed that for the propulsion unit to comprise a housing (4) that contains the motor, wherein an end region of the housing is provided with a heat exchange mechanism (59) arranged to cool cooling gas passing thereover, the heat exchange mechanism being associated with the housing such that, in use, water surrounding the housing absorbs heat therefrom. The unit can be arranged to make use of either, or both, of the features.
Patent DK-1459762-T3 (DK)
Inventor: YASUDA YOSHIKO
IPC: A61K38/18
Filed: 2002-11-01
Granted: 2008-10-06
Abstract: An agent for prophylaxis or treatment of proliferative organ diseases, chronic arthritic diseases, hypertrophic scars or keloid, comprising an erythropoietin receptor antagonist or a salt thereof.
Patent DK-1427315-T3 (DK)
Inventor: DAVIDSON MICHAEL B
IPC: A47F3/04
Filed: 2002-08-20
Granted: 2007-02-12
Abstract: A temperature controlled service case for storage and display of chilled or frozen products, including at least one compartment for product storage, at least one access opening providing entrance to the compartment, at least one shelf within the compartment for holding product, and refrigeration operatively associated with the compartment for maintaining a selected temperature therein. The refrigeration includes at least one cooling coil above the shelf with a cooling medium flowing therethrough, and cooling within the shelf with a cooling medium flowing therethrough. Coolant supply is also provided for supplying cooling medium to the cooling coil and shelf.
Patent DK-1468041-T3 (DK)
Inventor: MARCHESINI ALESSANDRO
IPC: C08F291/02
Filed: 2002-11-20
Granted: 2007-07-02
Abstract: The invention relates to a composition compriseing an at least bifunctional acidic prepolymer (A) curable under the action of heat an compound of the formula (I) in which A is a mono- to tetravalent, saturated or unsaturated alkyl group having 1 to 60 carbon atoms, a mono- to tetravalent aryl group, a mono- or diaiylamino group having 1 to 4 carbon atoms, an alkenylene group having 2 to 4 carbon atoms, a carboxyalkylene group or an alkoxycarbonylalkylene group having 1 to 4 carbon atoms, n is 1 or 2, m is 2-n, q is a number from 0 to 3, R<1 >is hydrogen or an alkyl group having 1 to 5 carbon atoms or a hydroxyalkyl group having 1 to 5 carbon atoms and X is a radical of the formula in which R<3 >and R<4 >are identical or different and, independently of one another, are hydrogen, a straight-chain or branched alkyl group or hydroxyalkyl group having 1 to 5 carbon atoms, or R<3 >and R<4>, together with the carbon atom to which they are bonded, form a cycloaliphatic ring. The composition is suitable for the production of printed circuits.
Patent DK-1511389-T3 (DK)
Inventor: ASGEIRSSON KARL JOHANN
IPC: A23L17/10
Filed: 2003-05-22
Granted: 2007-01-08
Abstract: The invention relates to a method, an apparatus and a product making it possible to work with block-frozen raw materials in a smaller format in various ways in the fields of the bait and the fodder industries, more particularly in the fields of bait, where the method consists of making the block-frozen raw material smaller by the raw material being shredded, scraped or planed down to rather small shreds or flakes of various fine consistencies in a freezer cabin at a common storage freezing temperature in such a way, that the temperature of the frozen small shreds or flakes does not increase considerable during the execution of the method. The method is executed both by using manual shredders of various types or by using a special apparatus intended and invented for the said use, where the hardened edges of the plane teeth of the apparatus have nicks such that the edges are "teethed" with different locations of the nicks such that two and two plane teeth being identical and located crosswise from each other on the disk.
Patent DK-1585862-T3 (DK)
Inventor: WIRTZ HEINZ-PETER
IPC: E01B29/40
Filed: 2003-11-15
Granted: 2006-10-02
Abstract: Spindle device for the height adjustment and alignment of tracks on a substructure, having a transverse cantilever which is fixed to an elongate nut adjustable in height on a height adjustment spindle and which engages under the rail and which is formed as a horizontal spindle plate which is mounted on the elongate nut pivotably about a horizontal axis and on which a slide provided with a clamping mount device for the rail foot is displaceable by means of a second spindle device transverse to the height adjustment spindle.
Patent DK-1583830-T3 (DK)
Inventor: HAURUM JOHN S
IPC: C12N15/85
Filed: 2004-01-07
Granted: 2007-01-15
Abstract: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the library, which encodes a distinct member of a polyclonal protein that binds a particular antigen and which is located at the same single site in the genome of individual cells in said collection, wherein said nucleic acid sequence is not naturally associated with said cell in the collection. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a library of vectors for site-specific integration. The present method is suitable for manufacturing recombinant polyclonal antibodies, thereby making available a superior replacement of plasma-derived therapeutic immunoglobulin products.
Patent DK-1633784-T3 (DK)
Inventor: PILKINGTON GLENN
IPC: A61K47/48
Filed: 2004-05-10
Granted: 2011-10-24
Abstract: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
Patent DK-1660213-T3 (DK)
Inventor: BARDON SEBASTIEN
IPC: F01N3/022
Filed: 2004-07-15
Granted: 2007-06-04
Abstract: The inlet channels and outlet channels are in communication with the fluid via their side walls. The hydraulic diameter of the outlet channels is between 0.9 and 1.4mm; the ratio r of the global volume of the inlet channels to the global volume of the outlet channels (Ve/Vs) is between 1.15 and 4, and the filtration surface is between 0.825 m 2> and 1.4m 2> per litre of the filter block : The global volume (Ve) of the inlet channels is greater than that (Vs) of the outlet channels. The hydraulic diameter of the outlet channels is more than 0.95mm and the ratio r is greater than 1.35 but less than 3. The filtration surface is more than 0.92m 2> per litre of the filter block. The outlet channels have a cross section of constant area over the whole length of the filter block. The inlet and outlet channels are rectilinear and parallel. The inlet and outlet channels are laid out with respect to each other so the whole of the gas filtered by an inlet channel passes into the adjacent outlet channels. The inlet and outlet channels are delimited by unflat wall elements to increase the global volume of the inlet channels at the expense of that of the outlet channels. At least one of the unflat wall elements has a sinusoidal cross section. An independent claim is made for a filter body containing at least one block as described.
Patent DK-1670329-T3 (DK)
Inventor: SMITH SIMON PETER
IPC: A42B3/06
Filed: 2004-10-07
Granted: 2008-12-01
Abstract: A firefighter's helmet comprising an inner protective shell configured to be worn on its own as a helmet and an outer protective shell configured to be fitted over the inner shell and realizably retained thereon, a retaining mechanism for retaining the inner shell in the outer shell, wherein the retaining mechanism is moveable by a user whilst wearing the inner shell between a first position in which the retaining mechanism engages a said shell substantially to prevent relative movement between the two shells, and a second position in which the retaining mechanism permits relative movement of the shells whereby allowing the donning or doffing of the outer shell by the user.
Patent DK-1648878-T3 (DK)
Inventor: SUN QUN
IPC: A61K31/4545
Filed: 2004-07-23
Granted: 2009-08-10
Abstract: Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula:   
and pharmaceutically acceptable salts thereof, wherein Ar 1 , Ar 2 , X, R 3 , R 4 , and m are as disclosed herein.
Patent DK-1800644-T3 (DK)
Inventor: KHORASSANI ZADEH DAVID
IPC: A61H1/00
Filed: 2005-12-21
Granted: 2010-11-22
Abstract: The invention provides a device for applying a non-invasive therapeutically reproducible pressure massage to skin and underlying tissues of a patient's body. A Continuous Pressure Technique (CPT) device and fitted attachable accessory components are provided for use with massage therapy for a variety of target tissues of the patient's body. Said accessory components include features allowing the induction of a therapeutically adequate profound pressure with relatively little effort enabling a therapist to treat a number of treatment targets, and a number of patients without excessive fatigue to the therapist. The provided OPT device provides for the capability of remotely determining pressure applied to the patient's body simultaneously with use of the device.
Patent DK-2054443-T3 (DK)
Inventor: BARRACLOUGH ROGER
IPC: A61K39/395
Filed: 2007-08-28
Granted: 2010-11-15
Abstract: Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.
Patent DK-2106294-T3 (DK)
Inventor: DEVROE SEBASTIEN
IPC: B02C17/18
Filed: 2007-11-20
Granted: 2012-06-18
Abstract: Apparatus for drying mineral particles comprises a vertical upflow pipe (1) with a bottom inlet for gas, a side inlet (4) for the particles, a top outlet (3) for gas and entrained fines, a bottom outlet (2) for coarser particles, and turbulence-creating baffles (5) between the bottom outlet and the side inlet. An independent claim is also included for a continuous grinding plant of the closed circuit type, comprising a grinder, drying apparatus as above in which the coarser particles are recycled to the grinder, a separator for removing oversize particles from and recycling them to the grinder, and a filter for separating fine product particles from the gas.
Patent DK-2222207-T3 (DK)
Inventor: VERSCHUERE FRANK
IPC: A47C23/04
Filed: 2008-09-30
Granted: 2011-12-05
Abstract: The present invention relates to a bed system which comprises a mattress supporting structure. The bed system comprises a height adjustment system which comprises at least one rotatable multi-angular transverse beam comprising a plurality of transverse beam sides and an eccentric rotation axis which is accessible from outside said outer frame. The height adjustment system further comprises a rotation imparting member which is accessible from outside the outer frame and provided for rotating said at least one rotatable transverse beam about its eccentric axis. Said rotation imparting member is displaceable between a first and a second position. The first position is provided for rotating said at least one rotatable transverse beam about its eccentric axis and said second position is provided for blocking said at least one rotatable transverse beam in a desired height position with respect to said outer frame.
Patent DK-2354795-T3 (DK)
Title: Methods and compositions relating to Alzheimer's disease
Inventor: WESTBROOK JULES
IPC: G01N33/68
Filed: 2005-09-29
Granted: 2015-02-16
Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Patent DK-2364747-T3 (DK)
Inventor: PALTI YORAM
IPC: A61N1/40
Filed: 2005-12-05
Granted: 2018-04-30
Abstract: An electrode configured for placement in contact with a surface of a patient's body, the electrode comprising: a flexible support; and a plurality of parallel electrode elements (45; 55, 55') which are supported by the flexible support to permit the electrode to conform to the surface of the patient's body and separated by open spaces (48; 58), wherein the electrode elements (45; 55, 55') are made of conductive wire (43) surrounded by a dielectric coating (42) to insulate the conductive wire (43) from the patient's body when the electrode is placed in contact with the patient's body, wherein the open spaces (48; 58) are distributed and sized to permit moisture on the surface of the patient's body to escape via the open spaces (48; 58) when the electrode is placed in contact with the patient's body.
Patent DK-2258870-T3 (DK)
Inventor: MORGAN BARRY
IPC: C12Q1/68
Filed: 2006-06-09
Granted: 2013-03-18
Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotides tag.
Patent DK-2493508-T3 (DK)
Inventor: MASINI-ETEVE VALÉRIE
IPC: A61K47/14
Filed: 2010-10-27
Granted: 2018-09-03
Abstract: The present invention provides compositions and methods for providing sustained release of an active agent through the skin of a subject, wherein a pharmaceutical percutaneous composition comprises at least one fatty acid ester and a therapeutically effective amount of active agent.
Patent DK-3004378-T3 (DK)
Inventor: MEULEMAN WOUTER
IPC: C12Q1/68
Filed: 2014-05-22
Granted: 2018-03-26
Abstract: A method for determining the sequence of a target nucleic acid, including steps of contacting a target nucleic acid with a polymerase to sequentially remove nucleotide triphosphates from the target nucleic acid, wherein the nucleotide triphosphates that are removed have a variety of different base moieties; and distinguishing the different base moieties for the nucleotide triphosphates that are removed. Also provided is an apparatus including a nanopore positioned in a fluid impermeable barrier to form a passage through which a nucleotide triphosphate can pass from a first fluid reservoir to a second fluid reservoir, and a reaction mix in the first fluid reservoir that includes a polymerase, target nucleic acid having two strands, and pyrophosphorolytic concentration of pyrophosphate.
Patent DK-3066201-T3 (DK)
Inventor: BORISY ALEXIS
IPC: C12N15/63
Filed: 2014-11-07
Granted: 2018-06-06
Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
Patent DK-3097086-T3 (DK)
Inventor: LOENN HANS ROLAND
IPC: C07D417/12
Filed: 2015-01-23
Granted: 2018-02-05
Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), 
     
       
         
         
             
             
         
       
     
     that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.