Patent SG-11201808994Y-A (SG)
Title: Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
Inventor: SHORT JAY M
IPC: G01N33/68
Filed: 2017-04-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111111011111111011111011111101111011111 International Bureau ... .1 j ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/180842 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07K 16/28 (2006.01) G01N 33/68 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 47/50 (2017.01) A61K 39/00 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2017/027372 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 13 April 2017 (13.04.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/323,036 15 April 2016 (15.04.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: BIOATLA, LLC [US/US]; 11011 Torreyana TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Road, San Diego, CA 92121 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: SHORT, Jay M.; 12985 Via Esperia, Del mar, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, California 92014 (US). CHANG, Hwai Wen; 1318 Shad- ow Hills Drive, San Marcos, California 92069 (US). GW, KM, ML, MR, NE, SN, TD, TG). FREY, Gerhard; 13768 Via Cima Bella, San Diego, Cali- Declarations under Rule 4.17: _ fornia 92129 (US). — of inventorship (Rule 4.17(N)) (74) Agent: DUNLEAVY, Kevin J.; MENDELSOHN DUN- Published: = LEAVY, P.C., 1500 John F. Kennedy Blvd., Suite 312, = Philadelphia, Pennsylvania 19102 (US). — with international search report (Art. 21(3)) (81) Designated States (unless otherwise indicated, for every — with sequence listing part of description (Rule 5.2(a)) = kind of national protection available): AE, AG, AL, AM, = = (54) Title: ANTI-AXL ANTIBODIES, OF = 3 ng 75 inAb = 1.5 = = t a. 11 .4 ei 71' __ ot b ANTIBODY FRAGMENTS AND THEIR IMMUNOCONJUGATES 75 fig rrAbIlh 0 ill_ ! = 60 °C 10 ng mAb 10 ng mAbilh il 1 MIMI 0 _214 et74 = ' —PAL-_ AND USES THERE- 60 °C !Mut $ GC © QC There are 11 antibodies tester under each condition (i.e., 11 bars in each set of bars). The 11 bars under each condition from left to right represent respectively clones BAP063 10F10, BAP063.9-13-1-FIAG, BAP063.9-29-2-FLAG, BAPC63.9-45-2-FIAG, BAN/63.9-13-3- FLAG, BAP063 21 3 FLAG, BAP063.9-21-4-FLAG, BAP063.9-29-4-FLAG, BAP063.9-48-3-FLAG. non-specific rhAh, no mAh 11 FIG. 5 N 11 0 (57) : A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Axl \" protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable re - Cgion that bind to Axl protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody frag- ments containing the polypeptide are also provided.