Patent RU-2706137-C2 (RU)
Title: Delivery devices, systems and methods for delivering therapeutic materials
Inventor: LEVIT REBECCA
IPC: A61M25/00
Filed: 2015-10-13
Granted: 2019-11-14
Abstract: FIELD: medicine. 
     SUBSTANCE: group of inventions refers to medicine, namely to delivery devices and methods for delivering therapeutic material(s) not requiring invasive cardiac surgery and which can enable delivery of the biomaterial with embedded stem cells, cytokines, drugs, biopreparations, as well as other additional therapeutic agents in the heart, for example, through pericardium. Device for delivering one or more therapeutic materials to a treatment site comprises a body; an element which is movable relative to the body and unfolding from the body and which is configured to be connected and/or overlapped with respect to itself and/or the body when it is turned from the body to form a barrier region at the point of treatment; and delivery cavities configured to deliver one or more therapeutic materials into the barrier region. Said element comprises at least two sets of delivery holes. Each set of delivery holes communicates with one of the delivery cavities and is configured to deliver the therapeutic material into the barrier region. In compliance with second version, device for delivery of one or more therapeutic materials to a treatment site comprises two elements, each of which is movable relative to the body and unfolding from the body and is configured to be connected and/or overlapped relative to the other member when it is turned from the body to form a barrier region at the treatment site; and delivery cavities configured to deliver one or more therapeutic materials into the barrier region. At least one of said elements comprises at least two sets of delivery holes. According to a third embodiment of the device for delivering one or more therapeutic materials to a treatment site, the element comprises at least one set of one or more openings arranged on the surface of said element and configured to provide suction, and at least one set of delivery holes arranged on the surface of said element such that the holes surround the barrier region and are configured to deliver at least one therapeutic material. According to the fourth embodiment, the device for delivering one or more therapeutic materials to a treatment site comprises two elements, at least one of said elements comprises at least one set of one or more openings located on surface of said at least one element and configured to provide suction, and at least one set of delivery holes arranged on the surface of said at least one element such that the holes surround the barrier region and are configured to deliver at least one therapeutic material. Method of delivering one or more therapeutic materials into the pericardial space includes pulling the member into the pericardial space through the body of the device; forming a barrier region within the pericardial space by connecting or covering said element relative to itself and/or the body; and delivering one or more therapeutic materials into the barrier region through one or more delivery ports arranged on the surface of said member. According to a second embodiment of the method of delivering one or more therapeutic materials into the pericardial space, two elements are projected into the pericardial space through the body of the device; forming a barrier region within the pericardial space by connecting or overlapping one of said elements relative to the other; and delivering one or more therapeutic materials into the barrier region through one or more delivery ports arranged on the surface of said elements. 
     EFFECT: inventions provide effective, less invasive and safe delivery of therapeutic materials to an area such as a heart. 
     46 cl, 17 dwg