Patent SG-11201906198P-A (SG)
Title: Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
Inventor: SCHUSTER HEIKO
IPC: C07K14/705
Filed: 2018-01-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIPO I PCT ill 1111u°11101VIIIVIIIVIIIolo VIII ioo Imo oimIE (10) International Publication Number WO 2018/138257 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) (21) International Application Number: PCT/EP2018/051952 (22) International Filing Date: 26 January 2018 (26.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10 2017 101 671.6 27 January 2017 (27.01.2017) DE 62/451,255 27 January 2017 (27.01.2017) US (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-Strasse 15, 72076 Tiibingen (DE). (72) Inventors: SCHUSTER, Heiko; Dorfackerstrasse 22, 72074 Tiibingen (DE). PEPER, Janet; Friedrich-Schaal- Strasse 6, 72074 Tiibingen (DE). ROHLE, Kevin; Eber- hardstrasse 25, 72072 Tiibingen (DE). WAGNER, Philipp; Bopserstrasse 2, 70180 Stuttgart (DE). RAMMENSEE, Hans-Georg; Sommerhalde 3, 72070 Unterjesingen (DE). (74) Agent: BOEHMERT & BOEHMERT; Jan B. KRAUSS, Pettenkoferstrasse 20 - 22, 80336 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) N cc 00 O C (54) Title: NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.