baber/WOPTO huggingface dataset:
Patent AU-2018256668-A1 (AU)
Title: Combination therapy comprising an inhibitor of JAK, CDK and PIM
Inventor: CAO ZHU ALEXANDER
IPC: A61K31/444
Filed: 2018-11-02
Abstract: C:\Interwoven\NRPortbl\DCC\DAR\17968894 I.docx-I I/2018 The present invention relates to a pharmaceutical combination which comprises (a) a JAK inhibitor compound, (b) a CDK inhibitor, and (c) a PIM kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of myeloid neoplasm or leukemia; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a mammal, especially a human.
Patent AU-2018258575-A1 (AU)
Title: Hepatitis C virus gene sequences and methods of use therefor
Inventor: CROWE JAMES E
IPC: A61K39/39
Filed: 2018-04-27
Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
Patent AU-2018258588-A1 (AU)
Title: Inhibitors of TRIM33 and methods of use
Inventor: QI JUN
IPC: C07D471/04
Filed: 2018-04-27
Abstract: The application relates to a compound of Formula (I): which modulates the activity of TRIM33, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which TRIM33 plays a role.
Patent AU-2018266091-A1 (AU)
Title: Multispecific protein drug and library thereof, preparing method therefor and application thereof
Inventor: CHOU JAMES JEIWEN
IPC: A61K38/00
Filed: 2018-03-22
Abstract: Provided are a multispecific protein drug and a library thereof, a preparing method therefor and an application thereof. Specifically, a protein drug library is provided and comprises C different protein drug monomers, wherein the protein drug monomer comprises a protein drug component part and a nucleic acid component part connected with the protein drug component part, and the nucleic acid component part of one protein drug monomer establishes a double-stranded paired structure with a nucleic acid component part of at least one different protein drug monomer by means of complementation, thereby constituting a protein drug polymer, wherein C is a positive integer greater than or equal to 2.
Patent AU-2018270906-A1 (AU)
Title: Compositions and methods for treating alzheimer's disease
Inventor: FU XIN-YUAN
IPC: C07K14/555
Filed: 2018-05-09
Abstract: Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.
Patent AU-2018271937-A1 (AU)
Title: Antisense therapies for treating cancer
Inventor: BELL ROBERT J A
IPC: A61K48/00
Filed: 2018-05-24
Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.
Patent AU-2018280354-A1 (AU)
Title: Improvements to artificially intelligent agents
Inventor: ESCOTT EBAN PETER
IPC: G06N3/00
Filed: 2018-06-08
Abstract: A system and method are provided for building computer software applications. More specifically the present invention relates to an artificially intelligent software agent or bot, which is able to read and update the underlying model utilised to build the software application. The bot includes a model comprising a representation of the target software, the bot then conducts a conversation with a human modeller according to a conversation tree to elicit a requirements specification from the modeller for the target software. Based on the requirements elicited through the conversation process the bot modifies the model for the target software accordingly.
Patent AU-2018288520-A1 (AU)
Title: Combination of a Mcl-1 inhibitor and a standard of care treatment for hematologic cancers, uses and pharmaceutical compositions thereof
Inventor: WEI ANDREW
IPC: A61K31/5377
Filed: 2018-06-21
Abstract: A combination comprising a Mcl-1 inhibitor and a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines, cytarabine and hypomethylating agents, and compositions and uses thereof.
Patent AU-2018293457-A1 (AU)
Title: In situ serial dilution method
Inventor: GUIGNET EMMANUEL
IPC: G01N33/543
Filed: 2018-06-22
Abstract: Provided herein are methods of determining a concentration of an analyte in a sample using in situ serial dilution.
Patent AU-2018302427-A1 (AU)
Title: Tool for cutting a workpiece
Inventor: FRENKEN EGBERT
IPC: B23D29/00
Filed: 2018-07-17
Abstract: The invention relates to a tool (1) for cutting a workpiece (24), said tool having a tool head (18) which has a receiving contour (23), the workpiece (24) being receivable in said receiving contour (23), wherein the tool head (18) also has a movable cutting edge (13) with a cutting contour, wherein the cutting edge (13), in the course of a cutting process, passes through the receiving contour (23), wherein, in addition, the cutting edge (13) is subjected to the effect of an advancement part (14) and can be moved to such an extent in the cutting direction (s) that it can pass all the way through a received workpiece (24). In order to further improve a tool of the type in question in terms of ease of handling and in terms of the cutting process, a first approach is that, from a position of the cutting edge (13) reached after the cutting edge has passed all the way through, the cutting edge (13), with removal from the advancement part (14), can be moved out from the cutting direction (s).
Patent AU-2018308955-A1 (AU)
Title: Telescopic electromechanical dual-control smart lock
Inventor: LEUNG MAN SHUN SERVER
IPC: E05B47/00
Filed: 2018-12-17
Abstract: Telescopic electromechanical dual control smart lock A telescopic electromechanical dual-control smart lock includes: a lock cylinder mechanism, a transmission mechanism and a power supply control mechanism; wherein the lock cylinder mechanism comprises a bolt, a lock core PCB (printed circuit board) board, a positive electrode sheet, a negative electrode sheet and a first spring; the power supply control mechanism comprises a main control PCB board and a detachable battery; wherein the positive electrode sheet, the negative electrode sheet and the transmission mechanism are electrically connected with the lock core PCB board respectively; wherein a first end of the transmission mechanism is pressed against an end of the first spring; a second end of the transmission mechanism is fixedly connected with the bolt; when the first spring is pressed, the bolt is retracted, and when the first spring is expanded, the bolt is stretched out; the lock cylinder mechanism and the transmission mechanism are provided side by side, and the main control PCB board is electrically connected with the lock core PCB board and the detachable battery respectively. By combining the conventional mechanical lock core with the smart lock cylinder, and controlling the transmission mechanism by the main control PCB, the present invention is suitable for the mechanical structure designed by the lock cylinder of the lock for the conventional drawer or cabinet door.
Patent AU-2018311245-A1 (AU)
Title: Automated system for robotised construction and construction method
Inventor: BECERRIL HERNÁNDEZ GERMÁN
IPC: E04G21/16
Filed: 2018-07-26
Abstract: The present invention provides an automated system for constructing and assembling walls, floors, roofs and stairs. The system comprises: at least one robotic arm; at least one tool for securing materials; at least one system for sliding, rotating and lifting; and male-female coupling elements.
Patent AU-2018334254-A1 (AU)
Title: Function-based probes for environmental microbiome analysis and methods of making and using the same
Inventor: WRIGHT AARON T
IPC: G01N33/58
Filed: 2018-09-14
Abstract: Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.
Patent AU-2018341840-A1 (AU)
Title: Generating a monochrome image
Inventor: FRANKLIN CRAIG R
IPC: H04N1/40
Filed: 2018-07-27
Abstract: Systems and methods are described for generating a monochrome image from a color filter array. Image data from an image capturing device may be received having a color filter array comprising a plurality of filter positions. The image data may be interpolated to de-mosaic the image data into three sets of data representing red, blue, and green (RGB) data, respectively, for each of the plurality of filter positions. A weight may be calculated for each value of the RGB data based on a local gradient calculated for each value of the RGB data. A pixel value may be calculated for each pixel position for generating a monochrome image using the weight for each value of the RGB data.
Patent AU-2018346962-A1 (AU)
Title: Methods of treating radiation induced gastrointestinal syndrome
Inventor: SUBHRAJIT SAHA
IPC: A61N5/10
Filed: 2018-10-12
Abstract: The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, oral mucositis, mucositis, and proctitis by the administration of a compound Yel002/BCN057 or an analog thereof.
Patent AU-2018360416-A1 (AU)
Title: Apparatus, modular tracking unit and method for conveyor belt alignment
Inventor: KALLARACKAL MANOJ JOSEPH
IPC: B65G39/16
Filed: 2018-10-31
Abstract: The various embodiments of the present invention disclose an apparatus, modular tracking unit and a method for conveyor belt alignment. The apparatus provides alignment sustenance and wide-angle coverage. The apparatus incudes a plurality of modular tracking units, a linking mechanism including a connecting rope passing through a link of each of the modular tracking units and a pair of guide rollers. The invention triggers the pair of guided rollers on mis-alignment of the conveyor belt from original path. The guided roller activates the linking mechanism to move the modular tracking units in tandem for re-aligning the conveyor belt.
Patent AU-2018369621-A1 (AU)
Title: High productivity methods for growing algae
Inventor: TRAN MILLER
IPC: C12N15/65
Filed: 2018-11-13
Abstract: The present disclosure provides for growing algae with an exogenous organic carbon source as the primary carbon source, in light, dark or limited light conditions. Also provided are expression cassettes for expression of a recombinant protein in an algae species grown in dark or limited light conditions.
Patent AU-2018387689-A1 (AU)
Title: Method and system for imaging at high and low light levels
Inventor: BENNAI BAYA
IPC: H04N5/343
Filed: 2018-12-17
Abstract: The invention relates to a method for imaging a scene using an imaging system making it possible to obtain an image of the scene, the imaging system comprising a device for acquiring frames according to acquisition parameters, and a unit for processing the acquired frames. The method comprises the steps: A) selection of an imaging mode from among a conventional imaging mode, a natural photon-counting imaging mode and a forced photon-counting imaging mode, and, depending on the selected imaging mode, determination by the processing unit of corresponding acquisition parameters, B) acquisition of at least one frame by the acquisition device parameterized with said acquisition parameters, and transmission of the frames that were acquired to the processing unit in order to obtain an image, the image being obtained at the end of the following sub-steps if the selected imaging mode is the natural photon-counting imaging mode or the forced photon-counting imaging mode: -binarization of the frames that were acquired and -summing the binarized frames to obtain an image, C) estimation of the quality of the image obtained, D) D1) depending on the quality of the image obtained, determining a new imaging mode selected among the conventional imaging mode, the natural photon-counting imaging mode, and the forced photon-counting imaging mode, D2) repeating steps A, B, C and D with the new imaging mode selected as the imaging mode.
Patent AU-2018392686-A1 (AU)
Title: Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
Inventor: LEE EUN SOO
IPC: A61K9/00
Filed: 2018-12-20
Abstract: Methods, compositions, and devices for transdermally administering a memantine salt wherein the salt forming compound is selected from an alpha-hydroxy carboxylic acid, an aliphatic carboxylic acid, an aromatic carboxylic acid, and a keto acid, are provided.
Patent AU-2018396969-A1 (AU)
Title: Multispecific chimeric receptors comprising an NKG2D domain and methods of use thereof
Inventor: FAN XIAOHU
IPC: C12P21/00
Filed: 2018-12-28
Abstract: Provided are chimeric receptors targeting NKG2D, and multispecific chimeric receptors comprising an NKG2D domain and a second antigen binding domain such as an IL-3 domain. Also provided are dual chimeric receptor systems comprising a first chimeric receptor comprising an NKG2D domain, and a second chimeric receptor comprising a second antigen binding domain such as an IL-3 domain. Further provided are engineered immune effector cells (such as T cells), pharmaceutical compositions, kits and methods of treating cancer.
Patent WO-2020028949-A1 (WO)
Title: Electrochemical flow reactor
Inventor: HORNE MICHAEL DAVID
IPC: H01M2/14
Filed: 2019-08-07
Abstract: The present disclosure relates to an electrochemical flow reactor, such as a continuous flow electrochemical tubular reactor. This disclosure also relates to processes, systems, and methods comprising an electrochemical flow reactor. An electrochemical flow cell can comprise a reaction chamber, a first static mixer electrode, a second counter electrode, and a separator disposed between the first and second electrodes.
Patent WO-2020037376-A1 (WO)
Title: Compositions and methods for reducing bacterial aggregation
Inventor: HERAS BEGONA
IPC: A61K39/40
Filed: 2019-08-23
Abstract: The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.
Patent AU-2019203303-A1 (AU)
Title: Medication requisition fulfillment system and method
Inventor: SCHNEIDER DENNIS I
IPC: G16H10/60
Filed: 2019-05-10
Abstract: Abstract A system and associated method are provided for fulfillment of medication requisitions corresponding to contained medication units. Requisition fulfillment logic may be included to provide decision data to a patient care provider for use in selecting one of a plurality of different fulfillment sites to fill a given medication requisition. A requisition router may route the medication requisition to a selected one of the plurality of fulfillment sites. The fulfillment sites may provide medication requisition metadata (e.g., data relating to the preparation and handling of medication units) to a medication requisition database in corresponding relation to the corresponding medication requisitions fulfilled by the fulfillment sites. The medication requisition metadata may be stored in the medication requisition database and accessed to facilitate enhanced management functionalities in relation to medication units dispensed by patient care providers. MEDICATION REQUISITION 100 MEDICATION MANAGEMENT NETWORK REQUISITION PATIENT CARE PROVIDER REQUISITION REQUISITION' -- -- -- ---- --- + FULFILLMENT -0---- - -- - I LOGIC I60b 60a 40 REMOTE REQUISITION REMOTE FULFILLMENT ROUTER ---- FULFILLMENT \J- \ PHARMACY FULFILLMENT S7TE]
Patent AU-2019203811-A1 (AU)
Title: Methods for producing transgenic plants
Inventor: AKULA ANISHA
IPC: A01H5/00
Filed: 2019-05-31
Abstract: METHODS FOR PRODUCING TRANSGENIC PLANTS A method of producing a stably transformed corn plant in a single container is 5 demonstrated. This method allows for the automation of the transformation process and reduces labor, material, and ergonomic costs associated with traditional plant tissue culture systems.
Patent AU-2019204417-A1 (AU)
Title: Systems and methods for authenticating online users in regulated environments
Inventor: GOSSET JULIA SHARON
IPC: G06F15/00
Filed: 2019-06-24
Abstract: SYSTEMS AND METHODS FOR AUTHENTICATING ONLINE USERS IN REGULATED ENVIRONMENTS An authentication platform for authenticating an online user in a transaction without use of strong consumer authentication (SCA) includes receiving an authentication request message for a transaction involving a regulated market includes authentication data and a transaction value, extracting the authentication data from the authentication request message, generating risk-based authentication (RBA) result data, determining that a risk of fraud in the transaction satisfies a risk threshold established by the regulatory entity by evaluating the risk score relative to the risk threshold, determining that the transaction value is below a transaction limit set by the regulatory entity, the transaction limit identifies a threshold transaction value below which strong consumer authentication may be avoided for transactions satisfying the risk threshold, and transmitting an authentication response message authenticating the transaction without strong consumer authentication having been performed based on satisfying the risk threshold and being below the transaction limit. -76-
Patent AU-2019216600-A1 (AU)
Title: A guidewire with an intergrated flexible tube
Inventor: GOVARI ASSAF
IPC: A61B17/00
Filed: 2019-08-12
Abstract: An integrated guidewire includes a wire and a flexible tube. The wire is sized and shaped to move in an anatomical material transportation system of a patient. The flexible 5 tube is sized and shaped to move in the anatomical material transportation system, having proximal and distal ends, the proximal-end is coupled to a device external to the patient, the flexible tube is configured to transfer fluids between the distal-end and the device, and the wire and the flexible 10 tube are intertwined with respect to one another. Insert into an anatomical material transportation system of a patient an integrated guidewire comprising a wire intertwined \100 with an optical fiber or with a tube for transferring fluids. Navigate the integrated guidewire 102 to an organ in question. YES Investigate a potential clot in patient organ? Irrigate NO supply NO the organ? drug to the organ. Supply irrigation fluid Administer a to the organ through substance to the organ 106 the tube. through the tube. 116 Acquire Carry-out anatomical Retract the integrated another information from guidewire from patient body. procedure the organ. 200 Provide a wire sized and shaped to move in an anatomical material transportation system of a patient. 202 Form an integrated guidewire by intertwining the wire and an optical fiber / tube for transferring fluids with respect to one another. 204, Couple the proximal end of the integrated guidewire to a medical device external to patient body.
Patent AU-2019224039-A1 (AU)
Title: Beverage dispenser systems and methods
Inventor: BHUTANI GURMEET SINGH
IPC: B67D1/04
Filed: 2019-02-21
Abstract: A beverage dispensing system is provided, including a main body that includes an interior cavity adapted to receive a beverage container, an adaptor module, and a controlled gas system. The adaptor module is configured to provide fluidic coupling from the beverage container to the controlled gas system, such that a beverage may be dispensed through from a tap connected to the adaptor with the aid of positive gas pressure disposed on a beverage surface within the beverage container. The controlled gas system exerts a positive pressure on a surface of the beverage in the beverage container such that when a tap is opened to dispense the beverage, the relative pressure difference between the positive pressure on the surface of the beverage and the ambient pressure causes the beverage to be dispensed from the tap.
Patent AU-2019231696-A1 (AU)
Title: Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer
Inventor: BREIJ ESTHER
IPC: A61K39/395
Filed: 2019-03-06
Abstract: The invention provides methods and compositions for treating cancer, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer).
Patent AU-2019245374-A1 (AU)
Title: Digital design tools for building construction
Inventor: JONES STEPHAN ALEXANDER
IPC: G06Q10/10
Filed: 2019-03-29
Abstract: Systems and methods are disclosed for digital design tools. One example method comprises obtaining an electronic model of a structure, the electronic model including a objects, and the objects representing physical objects to be constructed. Dependencies between the objects are determined, with the determined dependencies indicating that a first object is to be constructed prior to a second object. Construction orderings are generated based on the determined dependencies, with each construction ordering indicating a unique order in which the objects are to be constructed. A user interface is presented via a user device describing the construction orderings, with a system being configured to trigger updates to the electronic model in response to received material changes associated with the electronic model.
Patent AU-2019281328-A1 (AU)
Title: Floor panel and method for manufacturing a floor panel
Inventor: VAN VLASSENRODE KRISTOF
IPC: B32B27/08
Filed: 2019-05-09
Abstract: A floor panel comprising at least one substrate and a top layer, wherein the substrate comprises at least one first layer of a first thermoplastic material and a second layer of a second thermoplastic material, wherein the second layer is adjacent to a first side of the first layer and the second layer provides the floor panel with its underside. The first layer is characterized by a first colour with saturation value S1 in the HSL colour space and the second layer is characterized by a second colour with saturation value S2 in the HSL colour space, wherein S1 is less than S2.