baber/WOPTO huggingface dataset:
Patent CA-2412183-A1 (CA)
Title: Rtvp based compositions and methods for the treatment of prostate cancer
Inventor: REN CHENGZHEN
IPC: C07K14/47
Filed: 2001-06-08
Abstract: This invention relates to a gene encoding RTVP that has been shown to be up- regulated by p53 using differential display-PCR and subsequently by co- transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, but is significantly down regulated in metastatic mouse and human prostate cancer. In prostate cancer cells overexpression of the mouse RTVP-1 gene (mRTVP-1) induced apoptosis th at was accompanied by increased caspase 8,9 and 3 activities. MRTVP-1-stimulate d apoptosis was also associated with increased levels of bax, bad and activate d BID; reduced levels of bcl-2 and bcl-XL; and cytosolic cytochrome c accumulation. Adenoviral-vector-mediated mRTVP-1 expression lead to potent growth suppression and antimetastatic activities in an orthotopic mouse mode l of prostate cancer in vivo. These therapeutic activities were associated wit h anti-angiogenic effects and importantly a local and systemic immune response . Accordingly, p53 was linked with suppression of metastasis through its induction of mRTVP-1, which can concurrently induce apoptosis, suppress agiogenesis and stimulate an antitumor immune response. Thus, the invention includes compositions and methods, based on RTVP nucleic acid, polypeptides,  and antibodies, for use in the treatment, prevention and detection of neoplastic disease and, specifically, metastatic prostatic neoplasia.</SDOAB >
Patent CA-2414974-A1 (CA)
Title: Method of providing auto-registration of an ip telephony end-point
Inventor: SEGELSTEIN DAVID J
IPC: H04M7/00
Filed: 2002-12-23
Abstract: An automatic registration procedure for IP telephony end-points is presented. A first-stage registration is performed which provides enough service capability to allow the customer or installer to use the end-point to create an account and to subscribe to the specific services and features desired by the customer. Then a second-stage registration is performed which provides the end-point with the full set of features subscribed to by the customer.
Patent CA-2415627-A1 (CA)
Title: Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
Inventor: MILLER ALAIN
IPC: C12M1/33
Filed: 2001-07-24
Abstract: The present invention is related to a recovery and purification method of (a ) biological(s) of interest produced by cells retained in a bioreactor under appropriate conditions and by appropriate means for producing the biological(s) inside the bioreactor having a volume higher than 1,5 l cultur e, and cultivated at a high cell density, preferably at a cell density higher than 10 x 106 cells/ml, said bioreactor being submitted to an acoustic sonoperfusion allowing the recovery of a sonoperfused medium from said bioreactor, characterised in that it is submitted thereafter directly to an Expanded Bed Specific Adsorption for the direct recovery and uninterrupted purification of said biological(s). The present invention is also related to  a process unit for recovering and purifying said biological(s) of interest.</S DOAB>
Patent CA-2415922-A1 (CA)
Title: Compositions pharmaceutiques contenant des composes dds
Inventor: SUGIE SHUICHI
IPC: A61K47/48
Filed: 2001-07-11
Abstract: L'invention concerne des compositions pharmaceutiques qui renferment des composés obtenus par liaison d'un dérivé polysaccharide porteur de carboxyle à un dérivé camptothécine par le biais ou non d'un espaceur. On améliore leur stabilité en stockage par l'adjonction d'un sucre ou d'un alcool de sucre et, s'il y a lieu, d'un régulateur de pH.
Patent CA-2417838-A1 (CA)
Title: Method for assaying for a substance that affects an sh-2 phosphorylated ligand regulatory system
Inventor: PAWSON ANTHONY
IPC: C12N9/12
Filed: 1991-10-31
Abstract: A method for assaying a medium for the presence of a substance that affects an SH2-phosphorylated ligand regulatory system. The method employs an SH2-like domain or a subdomain thereof and a phosphorylated ligand. The phosphophorylated ligand is capable of interacting with the SH2-like domain or a subdomain thereof to form an SH2-phosphorylated ligand complex. The SH2-like domain or subdomain and/or the phosphorylated ligand are present in a known concentration. The SH2-like domain or a subdomain thereof and the phosphorylated ligand are incubated with a substance which is suspected of affecting an SH2-phosphorylated ligand regulatory system. The method is carried out under conditions which permit the formation of the SH2-phosphorylated ligand complex. SH2-phosphorylated ligand complex, free SH2-like domain or subdomains thereof, or non-complexed phosphorylated ligand are assayed. The invention also relates to an isolated SH2-phosphorylated ligand complex; a method of using an isolated SH2-like domain or a subdomain thereof to screen for phosphorylated ligands which are active in an SH2-phosphorylated ligand regulatory system; a method of using an isolated SH2-like domain or a subdomain thereof to regulate the interaction of a signalling protein with a related phosphorylated ligand; and a pharmaceutical composition comprising an isolated SH2-like domain or a subdomain thereof for use as an agonist or antagonist of the interaction of a signalling protein with a related phosphorylated ligand.
Patent CA-2417949-A1 (CA)
Title: Cheville pour materiaux legers, et utilisation d'un embout de tournevis pour visser une telle cheville
Inventor: KERL GREGOR
IPC: F16B37/12
Filed: 2001-07-18
Abstract: L'invention concerne une cheville (1) pour matériaux légers, qui présente, sur sa partie extérieure, un filetage (3) autotaraudant, et, sur sa pointe, un élément de coupe (2), avec lequel elle peut être vissée dans du placoplâtre. A l'extrémité opposée à la pointe, l'ouverture intérieure de la douille présente une section (8) à six pans à laquelle est rattachée une zone (7) de l'ouverture intérieure dans laquelle une vis peut tarauder son trou. Pour visser la cheville, on utilise une zone (10) de l'embout de tournevis destinée véritablement à l'insertion dans le mandrin d'un outil d'entraînement, étant donné que cette zone à six pans fait saillie hors du mandrin de telle sorte qu'elle puisse s'insérer dans le creux (8) à six pans de la douille de cheville.
Patent CA-2418023-A1 (CA)
Inventor: VOUILLAMOZ JACQUES
IPC: A61K38/08
Filed: 2001-08-02
Abstract: The invention concerns combinations having synergy of action characterised in that they consist of a combination of quinupristine/dalfopristine with cefpirome, and compositions and presentation kits comprising same.
Patent CA-2418314-A1 (CA)
Title: System and method for incremental and continuous data compression
Inventor: SINGH AMIT P
IPC: H04L12/46
Filed: 2001-07-18
Abstract: A data compression system and method for that is capable of detecting (202) and eliminating (206) repeated phrases of variable length within a window of virtually unlimited size.
Patent CA-2419239-A1 (CA)
Title: Organization object for use as a business object, and method and system for providing same
Inventor: DESBIENS MARC
IPC: G06F17/30
Filed: 2003-02-19
Abstract: An organization object as a first class business modeling object, and method and system for providing same are disclosed. The organization object includes at least one data dimension reference, at least one user identifier defining intended recipients, and a mapping between each data dimension reference and at least one user identifier. The method includes the steps of referencing at least one data dimension, defining intended recipients, and mapping each data dimension reference with at least one intended recipient.< /SDOAB>
Patent CA-2420670-A1 (CA)
Inventor: CARPENTER ROBERT H
IPC: A23B7/10
Filed: 2001-08-30
Abstract: A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a strong oxyacid, wherein the resultant acidic composition is less corrosive to a ferrous metal than a solution of a mineral acid having the same acidic pH value as that of the acidic composition, and where in the acid composition is more biocidal than a mixture of the organic acid and metal salt of the organic acid which the mixture has the same acid normality value as that of the acidic composition. The acidic composition can be prepared by mixing at least one regenerating acid, at least one metal base, and at least one organic acid, wherein the amount of the regenerating acid is in excess of the equivalent amount of the metal base.
Patent CA-2421816-A1 (CA)
Title: Methods for manufacturing olefins from lower alkanes by oxidative dehydrogenation
Inventor: NIELSEN KENNETH ANDREW
IPC: C07B61/00
Filed: 2001-09-14
Abstract: The present invention provides methods for manufacturing olefins such as ethylene and propylene from lower alkanes, that is, methane, ethane and/or propane, by oxidative dehydrogenation at elevated pressure. The olefins are selectively recovered from unconverted lower alkane feed and reaction byproducts by using a complexation separation, such as an absorption separation that uses aqueous silver nitrate as the complexation agent. Catalysts are used that give high selectivity for oxidative dehydrogenation of lower alkanes to olefins at elevated pressure, such as a nonstoichiometric rare earth oxycarbonate catalyst.
Patent CA-2426002-A1 (CA)
Title: Retrieval of data related to a call center
Inventor: STATHAM STEVEN W
IPC: H04M3/22
Filed: 2001-10-23
Abstract: In recent times, communications service providers have been able to offer large business enterprises the ability to share call center operation among multiple geographically dispersed call centers. In particular, network- resident call handling technologies have been developed for performing some of the handling and queuing of each inbound call within the communications network, that is, before the call is forwarded to an ACD at a particular call center. However, by outsourcing a portion of the call center operations to a network-based call routing system, the call centers are no longer able to maintain direct control over, and are generally unable to directly access information, such as statistics, about the calls in the network or other call centers. Accordingly, an interface is provided that allows an entity to obtain information about calls within the network or other call center(s).
Patent CA-2427358-A1 (CA)
Inventor: BIESTER KLAUS
IPC: E21B33/06
Filed: 2001-10-30
Abstract: The invention relates to a manual control device (1) for controlling a device (3) that is subjected to the action of force in a direction counter to the control direction (2), particularly for use in the domain of crude oil or natural gas extraction, such as a blowout preventer (BOP), a valve, an actuator, a throttle or the like. Said manual control device is equipped with a rotating spindle (5) that can be connected to a displacing element (4) of the device (3), said displacing element being displaceable in the control direction (2), and with a manually controllable adjusting device (7) that is drive-connected to said rotating spindle via at least one gearing mechanism (6). The aim of the invention is to improve a manual control device of this type such that, also with low numbers of rotations of the adjusting device, forces which are already high can be transferred to the rotating spindle and thus to the displacing element, and to render assisting devices, such as hydraulics or the like, unnecessary. To this end, the gearing mechanism (6) comprises a ball screw (8) with a ball screw nut (9) and with the rotating spindle (5) provided as a peripheral rotating spindle, whereby the ball screw nut (9) is drive-connected to the adjusting device (7).
Patent CA-2427885-A1 (CA)
Title: Display device
Inventor: KOCHAN WILLIAM
IPC: G09F11/29
Filed: 2003-05-01
Abstract: A display device, according to the present invention, taking the form of a scroll with handle and a spool-rod shaft for rolling and unrolling printed flexible material and a tubular housing with an internal chamber -a floating cowling- freely rotatable over said wound spool-rod from which the printed material is extendable. The scroll text or image to be viewed is manually extendable by pulling it through a continuous longitudinal slit in the cowling with a pull-tab that prevents it from being irretrievably drawn into the cowling. The cowling is rotatably received at its open ends over the spool-rod by a pair of retaining aligning yokes. The invention improves on traditional scrolls by providing protective containment for the printed material without requiring the containment's separation for display.    The cowling and handle are adaptable as works of art related to the printed material.
Patent CA-2427899-A1 (CA)
Title: Microgranules based on active principle and method for making same
Inventor: COUSIN GERARD
IPC: A61K9/16
Filed: 2001-11-15
Abstract: The invention concerns a microgranule consisting of a core coated with at least a coating layer, said coated core comprising at least an active principle. The invention is characterised in that the core and said coating layer contain each between 80 and 95 wt. % of active principle, the complement to 100% consisting of at least a binding agent, and the coated core has a substantially spherical shape. The invention also concerns the method for making such microgranules.
Patent CA-2428700-A1 (CA)
Inventor: VALSAMIS LEFTERIS
IPC: B01F7/02
Filed: 2002-02-28
Abstract: Four wing rotors for use in an internal batch mixer. The rotor has two long wings, and these two long wings have different approach angles and helix angles. The rotor has two short wings and these short wings also preferably have different helix angles and approach angles. The rotors provide improved distributive and dispersive mixing allowing for greater productivity in processing materials and producing more homogeneously mixed materials at lower discharge temperatures.
Patent CA-2429593-A1 (CA)
Title: Tire pressure monitoring device
Inventor: LUNDQVIST TORBJORN B
IPC: B60C23/04
Filed: 2001-11-21
Abstract: A low tire pressure monitoring device that is affixed to a tire valve stem (22) and methods of using the same. The monitoring device comprises a housing (26) having a counter-pressure chamber (21), a main pressure chamber (94), and a flexible membrane (36) that separates the two chambers. The monitoring device is calibrated by trapping the tire initial air pressure in the counter pressure chamber (21). The air pressure within the main pressure chamber (94) is equivalent to the air pressure within the tire. Over the course of time, the air pressure within the tire and concomitantly the air pressure within the main pressure chamber decreases. When the pressure in the counter pressure chamber is greater than the pressure within the main pressure chamber (94), the flexible membrane (36) touches and completes an electrical circuit (27) and a warning signal is emitted.
Patent CA-2430461-A1 (CA)
Title: Process for hydrogenating an aromatic amine in the presence of a supported ruthenium catalyst
Inventor: FINKE NORBERT
IPC: C07C209/72
Filed: 2003-05-30
Abstract: The invention relates to a process for hydrogenating an aromatic amine that has at least one amino group bound to an aromatic nucleus with hydrogen in the presence of a supported catalyst that contains ruthenium as active metal.        The catalyst support of the catalyst to be used according to the invention has a BET surface area in the range from greater than 30 m2/g to less than 70 m2/g and more than 50% of the pore volume of the catalyst support is formed by macropores having a pore diameter of greater than 50 nm and less than 50% are mesopores having a pore diameter of 2 to 50 nm.        The process is suitable in particular for hydrogenating methylenedianiline to form bis(p-aminocyclohexyl)methane having a trans-trans isomeric component of 15 - 25%.
Patent CA-2431568-A1 (CA)
Inventor: CONNORS THOMAS
IPC: C11D1/86
Filed: 2001-12-07
Abstract: A light duty, liquid comprising: at least one linear alkyl benzene sulfonate, an alkyl polyglucoside surfactant, an ethoxylated alkyl ether sulfate surfactant, a fatty acid monoalkanol amide, an inorganic magnesium salt, lauryol ethylenediaminetriacetate, and water.
Patent CA-2432346-A1 (CA)
Title: Genome-wide location and function of dna binding proteins
Inventor: REN BING
IPC: C12Q1/68
Filed: 2001-12-21
Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA  comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
Patent CA-2434586-A1 (CA)
Title: Five-layered, biaxially-oriented tubular film for packaging and wrapping of meat or meat with bones and use thereof
Inventor: GRUND HARTMUT
IPC: A22C13/00
Filed: 2001-02-01
Abstract: The invention relates to a five-layered, biaxially-oriented, shrinkable and sealable tubular film for the packaging and wrapping of meat, or meat with bones and the use thereof. Said tubular film comprises an inner layer made from at least one heat-sealable co-polyamide, a middle polyolefin layer and an outer layer made from at least one homo-polyamide and two bonding layers between the inner and middle layers and the middle and outer layers. Such films are characterised by a superior resistance of the sealing join and hig h puncture-resistance.
Patent CA-2435304-A1 (CA)
Inventor: PARODI JUAN CARLOS
IPC: A61F2/06
Filed: 2002-01-18
Abstract: An introducer for implanting a prosthesis in a junction of a main lumen and a branch lumen. The prosthesis comprises a trunk to be implanted within the main lumen and at least one arm to be implanted within the branch lumen. The introducer comprises an outer sheath, an axial guide wire and at least one peripherical guide wire slideable within the outer sheath, and a nose cone at a distal end of the sheath. The nose cone has an axial conduit for receiving the axial guide wire and at least one peripheral channel for guiding the peripheral guide wire and guiding it into the branch lumen. A unitary branched prosthesis having at least one radial arm may be deployed using this introducer. Methods for deploying a unitary or modular branched prosthesis at a junction in a lumen use the introducer of this invention.
Patent CA-2435632-A1 (CA)
Inventor: FINLAY WARREN HUGH
IPC: A61K9/00
Filed: 2003-07-21
Abstract: Respirable particles carrying active principles or diagnostics in nanopartic le form are created by mixing the nanoparticles with liquid carrier, then forming th e resultant mixture into respirable particles. Spray-drying, freeze spray drying and drying followed by comminution may be used to create the respirable particles, which may be delivered to the lung via a dry powder inhaler. In one example, lactose was used as th e excipient and spray-dried with two different types of nanoparticle: gelatin and poly butylcyanoacrylate nanoparticles. The incorporation of nanoparticles did not affect the respirable fraction of the carrier powders.
Patent CA-2442829-A1 (CA)
Inventor: BEASLEY ELLEN M
IPC: C12Q1/68
Filed: 2002-03-28
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the prese nt invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
Patent CA-2443309-A1 (CA)
Inventor: LANDIS DAVID H JR
IPC: C01B33/40
Filed: 2002-03-26
Abstract: High-use temperature, lightweight polymer/inorganic nanocomposite materials are described having enhanced thermal stability and performance characteristics. These materials are made possible by new methods for synthesizing composite materials that enhance the thermal stability of the nanocomposite systems from 100-150 ~C to over 450 ~C. These materials and techniques for their formation are enabled at least in part by the use of polar organic phthalonitrile monomers and oligomers that can exfoliate layer ed phyllosilicates, such as smectite clays, in percentages greater than 10 % inorganic by weight. This approach offers a solvent-free direct melt intercalation technique that greatly reduces the cost of processing nanocomposites. Additionally, the use of unmodified phyllosillicates overcom es temperature limitations of prior art, which uses organically-modified layere d silicates. The new technology provides hitherto unobtainable thermal stabili ty and performance characteristics, and has numerous applications in the automotive, aerospace, electronic and marine industries.
Patent CA-2444177-A1 (CA)
Inventor: JAWOROWSKI MARK R
IPC: C25F5/00
Filed: 2003-10-03
Abstract: An electrochemical process for simultaneously stripping diverse coatings from a metal substrate and, more particularly to the removal of MCrAlY and aluminide coatings from a base metal.
Patent CA-2445701-A1 (CA)
Title: Ejector for electrical connector
Inventor: WALSE ALAN
IPC: H01R13/629
Filed: 2003-10-20
Abstract: A manually actuated ejector for electrical connectors for providing an initial disconnection movement between connector components includes a pivotal lever attached to one connector component having an actuator link connected thereto, the link terminating in a connection to a rotatable cam carried by the one connector part with a cam face in juxtaposition to an opposed surface of a second connector part whereby movement of the lever rotates the cam in opposition to the second connector part causing relative disconnection movement between the two connector parts.
Patent CA-2446815-A1 (CA)
Title: Intravascular platforms and associated devices
Inventor: BRUCKHEIMER ELCHANAN
IPC: A61F2/86
Filed: 2002-05-07
Abstract: An intravascular platform for supporting an intravascular device includes tw o loops of wire (100, 104) each configured to assume a shape lying generally o n a virtual cylinder of given diameter. The two loops (100, 104) are interconnected by at least one connecting wire (102) which maintains the loo ps axially spaced from each other. Also disclosed are axially-extended loop forms, and associated intravascular devices.
Patent CA-2448774-A1 (CA)
Inventor: SRINIVASAN VENKATARAMAN
IPC: H04L12/16
Filed: 2003-11-10
Abstract: A method for conducting a review including the step of detecting a payment request from a vendor; generating a review based on the payment request; and, transmitting a reference to the review to a customer, wherein the reference provides a link to retrieve the review. A system for performing the method is also described.
Patent CA-2449702-A1 (CA)
Inventor: SEVCIK PAUL A
IPC: G06F17/30
Filed: 2001-06-05
Abstract: Certain improvements related to the transfer and use of information are disclosed, including a the transfer of information from an existing database to a database used in conjunction with an RFID device of the type that may b e used to interrogate RFID tags associated with items associated with entries in the existing database.