baber/WOPTO huggingface dataset:
Patent CA-2529535-A1 (CA)
Inventor: CHANG CHIN-MING
IPC: A61K31/13
Filed: 2004-06-10
Abstract: This invention relates to an oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine or 20 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a lager dose of memantine. Other aspects of this invention relate to pharmaceutical products comprising said dosage forms and methods of administering memantine and treating disease with said dosage form.
Patent CA-2529945-A1 (CA)
Inventor: YANG TZUNG-HORNG
IPC: C07K16/00
Filed: 2004-06-28
Abstract: The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
Patent CA-2534029-A1 (CA)
Title: Fungicidal composition comprising a pyridylmethylbenzamide derivative and a sulfamide derivative
Inventor: WEGMANN THOMAS
IPC: A01N47/04
Filed: 2004-10-28
Abstract: A composition comprising at least a pyridylmethylbenzamide derivative of general formula (I) and N-dichlorofluoromethylthio-N~,N~-dimethyl-N-p-totylsulfamide; in an (a) /(b) weight ratio of from 0.01 to 10. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the phytopathogenic fungi of crops by using this composition.
Patent CA-2534836-A1 (CA)
Title: Supported polymerisation catalysts
Inventor: KIMBERLEY BRIAN STEPHEN
IPC: C08F4/645
Filed: 2004-08-04
Abstract: A supported polymerisation catalyst system is prepared by a method comprising the following steps: (i) addition of a cocatalyst to a porous support, (ii) mixing a polymerisation catalyst with a polymerisable monomer, and (iii) contacting together the components resulting from steps (i) and (ii). The porous support is preferably silica and the polymerisation catalyst is preferably a metallocene. The polymerisable monomer is typically 1-hexene and the supported catalyst system provides advantages a slowly decaying activity profile particularly when operating in the gas phase.
Patent CA-2537745-A1 (CA)
Inventor: RILEY JONATHAN G
IPC: B25F5/02
Filed: 2004-08-26
Abstract: A preferred embodiment comprises a power hand tool (10) of the type which has a generally cylindrical elongated plastic housing (14) with a motor contained within the housing (14) and having an output shaft (30) that extends from the front end portion (22) of the hand tool (10), and which has a metal front end portion (22) that cooperates with the plastic housing (14) to strengthen a shaft locking mechanism (32) located at the front end of the hand tool (10).  The metal front end portion (22) not only strengthens the outer , surface of the housing (14) in the front end portion (22) of the tool, but also has a pair of internal structural ribs (72) positioned to absorb stress that may be present in the housing (14) as a result of force applied to the shaft locking mechanism. The preferred embodiment is also designed to enable the shaft locking pin mechanism (32) to be easily assembled and retained without the need for an E-clip or C-clip as is commonly the practice in commercially available spiral saw hand tools (10).
Patent CA-2539557-A1 (CA)
Inventor: BALDWIN MICHAEL
IPC: F16B2/06
Filed: 2006-03-13
Abstract: A clamp is provided. The clamp comprises a body and a tension member that is disposed within the body. The tension member comprises a member clamp end that defines a first clamp face. The clamp also comprises a body clamp end positioned on the body.  The body clamp end defines a second clamp face that is spaced in relation to the first clamp face so as to define a clamp opening therebetween. The first and second clamp faces are configured to engage an item to be clamped. The tension member is extendable from the body by a degree sufficient to vary the spacing between the first and second clamp faces so as to accommodate the size of the item to be clamped. The remainder of the member not required for clamping remains disposed with the body. The clamp further comprises tension means positioned in relation to the tension member, which in turn comprise engaging means for engaging the tension means and applying a tensile force to the tension member. The tensile force is translated via the clamp ends as a compressive force on the item being clamped.
Patent CA-2540452-A1 (CA)
Title: Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
Inventor: SELNICK HAROLD G
IPC: C07D405/04
Filed: 2004-09-29
Abstract: The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Patent CA-2540868-A1 (CA)
Title: Pyrrolidinyl urea derivatives as angiogenesis inhibitors
Inventor: SAUER DARYL R
IPC: C07D471/08
Filed: 2004-10-08
Abstract: Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
Patent CA-2541717-A1 (CA)
Inventor: TANAKA RYO
IPC: A44B19/24
Filed: 2006-04-04
Abstract: Top end stops for slide fastener in which front ends of its fastener chains are opened and no wrinkle is produced by a diamond of a slider, wherein a top end stop is molded with resin such that it includes a notch portion provided on an edge portion of a pair of fastener tapes and the top end stop is formed on a top face of the notch portion; the top end stop is formed at an end portion of a coupling element row with a gap from the coupling element, and a concave portion is formed to allow a diamond of a slider to escape; and an overlapping portion that a coupling head of a mating coupling element is capable of joining is formed at a bottom end of one of the top end stops , whereby the fastener chain can be closed completely by a slider, so that specified waterproof property and water cutout performance are secured.
Patent CA-2542832-A1 (CA)
Title: Dose indicating device
Inventor: LU WINSTON
IPC: G09F11/23
Filed: 2004-12-10
Abstract: An indicating device suitable for indicating the number of metered dosages that have been dispensed from or remain in a container includes a base member adapted to be mounted to the container and a cap member moveably connected to the base member. The cap member is moveable relative to the base member along an axial path. A shaft is non-rotatably mounted to one of the cap member and the base member and defines an axis. An indicator member is rotatably mounted on the shaft and is rotatable in at least a first direction. One of the shaft and the indicator member has a helical groove while the other of the shaft and the indicator member has a follower disposed in the groove. The indicator member is moveable relative to the shaft along the axis as the indicator member is rotated in the first direction. In another embodiment, the indicating device includes first, second and third indicator members. In yet another embodiment, the indicating device includes a housing having a longitudinally extending cavity shaped to receive the container and an indicator member disposed in the cavity and having a longitudinally extending wall shaped to surround at least a portion of the container. The indicator member is rotatably mounted within the housing and is rotatable relative thereto about a longitudinal axis. The indicator member includes a driven gear. A drive gear is disposed in the housing and includes a drive portion selectively engaged with the driven gear. An actuator is adapted to move with the container and is selectively engaged with the drive gear.
Patent CA-2543961-A1 (CA)
Title: Electrochemical test strip for reducing the effect of direct and mediated interference current
Inventor: LEIPER ELAINE
IPC: G06F19/00
Filed: 2004-10-29
Abstract: The present invention is directed to an electrochemical sensor (800) or electrochemical strip which includes a substrate (50), a first working electrode (808) disposed on the substrate, a second working electrode (806) disposed on the substrate, a refèrence electrode (810), an active reagent layer (820) disposed on the first working electrode (808), wherein the active reagent layer (820) completely covers the first working electrode (808) and an inactive reagent layer (818) disposed on the second working electrode (806), wherein the inactive reagent (818) completely covers the second working electrode (806). The present invention is also, directed to an electrochemical sensor (1000) including a substrate (50), a first working electrode (100) disposed on the substrate, a second working electrode (102) disposed on the substrate, a reference electrode (104), an active reagent layer (820) disposed on the first working electrode (100), wherein the active reagent layer (820) completely covers the first working electrode (100), the second working electrode (102) having an active region (102a) and an inactive region (102i), the active reagent layer (820) disposed on a active region (102a) of the second working electrode (102) and an inactive reagent layer (818) disposed on the inactive region (102i) of the second working electrode (102).
Patent CA-2544982-A1 (CA)
Title: Flow machine, slide ring seal thereof, body part for said slide ring seal and method of fastening said slide ring seal to said flow machine
Inventor: MANNINEN HEIKKI
IPC: F04D29/12
Filed: 2006-04-25
Abstract: The present invention relates to a new kind of a mechanical seal, a so called slide ring seal, which is used, for example, for sealing a shaft space of a centrifugal pump in relation to a pumping space thereof. The present invention especially relates both to centering said mechanical seal and/or fastening said mechanical seal to the casing of said centrifugal pump and a body part used for the attachment. A characterizing feature of a mechanical seal in accordance with the present invention, comprising at least one rotary slide ring unit (24, 24', 24"), a body part by means of which said seal is attached to said casing (16), and at least one either separate counter ring unit (42, 42') or a counter ring unit (42, 42') stationarily attached to said body part, is that said body part (40, 40') is provided with inclined fastening means (52), by means of which the body part (40, 40') is tightened to the casing both axially and radially.
Patent CA-2547455-A1 (CA)
Title: Method and apparatus for unified management of different type of communications over lan, wan and internet networks, using a web browser
Inventor: DIOMELLI GIUSEPPE
IPC: H04M7/00
Filed: 2004-03-16
Abstract: A method, and apparatus, for the unified management of all types of communications, such as: telephone calls, faxes, SMS and MMS, video, e-mails, CHAT and multimedia communications in general, allows to interface various communications/telecommunications networks and their related transmission protocols. All outbound and inbound communications are controlled and globally managed through an Internet Web Browser that also generates a historical log of the communications and their contents using a single database. All the functions required for the fully integrated management of all the said types of communications to and from every device connected to the LAN comprising the apparatus, and/or the WAN, and/or the Internet, are generated by applying the invention method, thereby producing a full Computer Telephony Integration (CTI). Thanks to the method in question, the management of all types of communications is achieved without the need for any telephone switchboard (PBX, PABX, IPPBX).
Patent CA-2548249-A1 (CA)
Inventor: ANDERSEN SIGNE KOLMOS
IPC: B01J2/06
Filed: 2004-12-17
Abstract: The present invention relates to processes for the preparation of a batch of an active pharmaceutical ingredient, e.g. an allergen product. The invention also relates to a container comprising cryogranules of a liquid composition of an allergen product, and to a cryogranule of an allergen product. The processes feature formation of cryogranules using a container having therein a cryogenic medium (e.g. liquid nitrogen) and storage of the cryogranules in the same container. The cryogranules obtained can be stored and handled without prior freeze-drying.
Patent CA-2548782-A1 (CA)
Inventor: CHAFFIN JOHN HARVIE III
IPC: C23C16/505
Filed: 2004-12-07
Abstract: The present invention provides films and substrates coated with films that comprise a nano-crystalline diamond matrix that is substantially free of graphite inclusions. The present invention also provides a method of chemical vapor deposition to prepare the films. The method of chemical vapor deposition operates at a DC  bias voltage that substantially precludes the formation of a plasma ion capable of causing a region of a nano-crystalline diamond matrix within a forming film to allotrope when the plasma ion collides with the film.
Patent CA-2548865-A1 (CA)
Inventor: TANG XIONG WEI
IPC: E05B67/22
Filed: 2006-05-30
Abstract: The invention provides a padlock with a quickly changeable shackle, comprising a locking core, a locking member, blocking balls, a lock body on which two limb receiving chambers and a passage are disposed, and a shackle which takes U-shape defined by a longer and a shorter parallel limbs respectively received in the limb receiving chambers to lock the padlock. A ring groove with an abutment head is disposed at the free end of the longer limb, and a depressed portion with a screw hole is provided on the circumferential surface of the abutment head. A shackle changing screw is threaded into the screw hole and the end face of the screw in the threaded position is higher than the depressed portion and lower than the circumferential surface of the abutment head. The invention further provides a padlock having a freely-convertible deadlock mechanism.
Patent CA-2551234-A1 (CA)
Title: Devisseur de bouchons
Inventor: MOLES JOAO CARLOS
IPC: B67B7/16
Filed: 2004-12-21
Abstract: L'invention concerne un dévisseur de bouchons se présentant sous forme d'un élément produit à partir de matériaux jetables et bon marché, destiné à venir se placer sur le col des bouteilles de boissons munies d'un bouchon vissé et présentant un filetage. Ce dévisseur (01) comprend des encoches (02) dans lesquelles les nervures externes du bouchon viennent s'imbriquer, facilitant ainsi le dévissage du bouchon de la bouteille de boisson. La paroi interne de ce dévisseur présente une forme conique (03) entre le haut et le bas, permettant de l'adapter de manière sûre sur le col de la bouteille.
Patent CA-2558252-A1 (CA)
Inventor: VAN DE LOO PAUL
IPC: F16B12/18
Filed: 2005-02-28
Abstract: A self-aligning coupling device (400) for installation in channel having an open end and a pair of substantially parallel side walls. The device includes an elongate connecting portion (402) having a longitudinal axis (404), a channel abutment portion (408), and at least one laterally projecting lug (412, 414). In use, the coupling device (400) is installed in the channel with the channel abutment portion (408) located at least partially within the channel and the laterally projecting lug (412, 414) located outside the open end of the channel. The channel abutment portion (408) is formed such that when aligned in a first angular position within the channel it abuts the side walls of the channel to prevent rotation of the device in a first rotational direction about said longitudinal axis, while allowing rotation in a second, opposed rotational direction.
Patent CA-2558685-A1 (CA)
Title: Nucleic acid construct containing fulllength genome of human hepatitis c virus, recombinant fulllength virus genome-replicating cells having the nucleic acid construct transferredthereinto and method of producing hepatitis c viral particle
Inventor: KATO TAKANOBU
IPC: A61K39/29
Filed: 2005-02-21
Abstract: It is intended to provide a method of efficiently replicating RNA containing the full-length genome sequence of HCV; a method of preparing viral particles of HCV containing full-length HCV replicon RNA or full-length HCV genome RNA  by using a cell culture system; a method of producing hepatitis C viral particles which comprises culturing cells having replicon RNA comprising the full-length RNA sequence of hepatitis C virus of the genotype 2a and a base sequence containing at least one selection marker and/or at least one reporter gene and at least one IRES sequence or the full-length genome RNA of hepatitis C virus of the genotype 2a to thereby allowing the production of viral particles in the culture medium; a hepatitis C vaccine; and an antibody against hepatitis C viral particles.
Patent CA-2559955-A1 (CA)
Inventor: KIM DONGHO
IPC: C12Q1/68
Filed: 2005-03-15
Abstract: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA ("dsRNA"), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery.
Patent CA-2560410-A1 (CA)
Inventor: ISHII TAKASHI
IPC: H01S5/0233
Filed: 2005-09-20
Abstract: A heat sink material, which is composed of an alloy or a composite material including two or more kinds of elements and is provided with at least an end plane by which an edge part can be formed for mounting a laser element. A  method for manufacturing such heat sink material, and a semiconductor laser device provided with such heat sink material are also provided. The heat sink material (10) is composed of the alloy or the composite material including two or more kinds of elements, has a relatively large area main surface and a relatively small area sub-surface intersecting the main surface. The sub-surface includes a surface to which electro-discharge machining is performed by arranging discharge wire (200) substantially parallel to the main surface.  The method for manufacturing the heat sink material (10) is provided with a step of arranging the discharge wire (200) substantially parallel to the main surface on materials (100, 50), and a step of performing the electro-discharge machining to the materials (100, 50) by using the discharge wire (200) arranged as mentioned above.
Patent CA-2561266-A1 (CA)
Title: Pyridyl-substituted porphyrin compounds and methods of use thereof
Inventor: WILLIAMS WILLIAM
IPC: C07F13/00
Filed: 2005-03-25
Abstract: The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.
Patent CA-2563843-A1 (CA)
Inventor: ASAKURA KIYOTAKA
IPC: G01Q60/24
Filed: 2004-12-21
Abstract: A quantum beam aided atomic force microscope and quantum beam aided atomic force microscopy that can realize simultaneously performing of atomic-level configuration observation and elemental analysis with the use of an atomic force microscope and further can effect analysis of the chemical state of sample surfaces and that as being operable in liquids, can realize the elemental analysis and chemical state analysis of biosamples with an atomic-level resolving power. Accordingly, atoms of sample surface are irradiated with quantum beams, such as charged particles, electrons and photons, having a given electron transition energy characteristic of element, and any change of interactive force between the atoms of sample surface having been irradiated with quantum beams and the distal end of the probe is detected.
Patent CA-2567244-A1 (CA)
Inventor: CARRAHER JOHN M
IPC: E04C5/16
Filed: 2005-05-17
Abstract: A fastener for joining two pieces of rebar together in a rebar grid used to reinforce subsequently poured concrete is described. The fasteners include two clamp pieces that in certain embodiments completely wrap around a piece of rebar and are tightly secured thereto. Further, each clamp piece can swivel or rotate up to 360 degrees relative to the other clamp piece such that two rebar pieces intersecting at any angle can be coupled together.
Patent CA-2568488-A1 (CA)
Title: System for integrating body equipment with a vehicle hybrid powertrain
Inventor: BISSONTZ JAY E
IPC: B60L50/10
Filed: 2006-11-22
Abstract: A control system for a hybrid vehicle equipped with power takeoff equipmen t provides a multi-bus, network environment, integrating operation of a vehicl e electric traction motor, power takeoff equipment including prospectively hydraulic motion control equipment and a vehicle thermal engine. The control system is readil y programmable to allow reconfiguration depending upon the character of the equipment installed. Efficient utilization of the vehicle's thermal engine a nd enhanced system robustness is obtained.
Patent CA-2569261-A1 (CA)
Inventor: OHRBOM WALTER
IPC: C09K23/52
Filed: 2006-03-21
Abstract: A coating composition comprises at least one material dispersed in a vinyl or acrylic polymer, wherein the vinyl or acrylic polymer comprises (a) one or more anchor group monomer units (a) having an ionizable or active hydrogen functionality or a functionality that forms a covalent bond with the dispersed material, wherein the ionizable functionality is other than a carboxylic acid group in which the carbonyl carbon is separated from the closest ethylenically unsaturated carbon by at least four atoms and the anchor group monomer units (a) are other than those having polyoxyalkylene groups; (b) about 5% to about 45% by weight of one or more stabilizer monomer units (b) having a carboxylic acid group in which the carbonyl carbon is separated from the closest ethylenically unsaturated carbon by at least four atoms, having polyoxyalkylene groups, having gamma-hydroxy carbamate or beta-hydroxy carbamate groups, and combinations thereof; and (c) up to about 50 percent by weight of aromatic monomer units.