baber/WOPTO huggingface dataset:
Patent HU-E034210-T2 (HU)
Title: Neprilysin inhibitors
Inventor: FENSTER ERIK
IPC: A61K31/42
Filed: 2014-03-04
Abstract: In one aspect, the invention relates to compounds having the formula: 
           
where R 1 -R 5  and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Patent TR-200003429-T2 (TR)
Title: Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.
Inventor: DOBRUSIN ELLEN MYRA
IPC: A61K31/519
Filed: 1999-05-10
Abstract: (FORMÜL VAR) Bu bulus, kanser ve restenozun yani sira anjiyojenez ve ateroskleroz gibi hücre çogalmasi hastaliklarinin tedavi edilmesinde faydali olan bisiklik heterosikller saglar. Sikline bagimli kinazlarin, büyüme faktörünün aracilik ettigi kinazlarin ve reseptör olmayan kinazlarin etkili inhibitörleri olan bir grup bisiklik bilesigi kesfettik. Bilesikler, kolaylikla sentezlenirler ve oral uygulama dahil olmak üzere çesitli yollardan uygulanabilirler ve klinik kullanim için yeterli biyolojik kullanisliliga sahiptirler.Bulus, Z'nin N veya GH; G'nin N veya CH; W'nin NH, S,SO veya SO2 oldugu; R1'in fenil ve ikameli fenili; R2'nin alkil ve sikloalkili; R3'ün alkil ve hidrojeni; R8 ve R9'un hidrojen ve alkili içerdigi Formül (I) bilesiklerini ve bunlarin farmasötik olarak kabul edilebilir tuzlarini içerir. Bulus ayrica farmasötik olarak kabul edilebilir bir tasiyici, seyreltici veya eksipiyanla birlikte Formül (I)'in bir bilesigini içeren farmasötik formülasyonlar da saglar.
Patent DE-602004003616-T2 (DE)
Inventor: MIYAJIMA HIROO
IPC: C09D183/00
Filed: 2004-05-06
Granted: 2007-10-04
Abstract: The present invention provides a member comprising a substrate, an undercoat film formed on a surface of the substrate, and a liquid-repellent film of metal alkoxide formed on a surface of the undercoat film. Also disclosed are nozzle head, liquid-jet head and liquid-jet device employing the above-described member. <IMAGE>
Patent DE-602004009325-T2 (DE)
Inventor: CHRISTENSEN STEEN BAK
IPC: H04B3/46
Filed: 2004-08-25
Granted: 2008-07-10
Abstract: Briefly, a system that may facilitate system and line loop back diagnostic operations. In one possible implementation, a first transceiver may transmit test signals to a second transceiver. The second transceiver may include a transmitter with the capability to reduce jitter in received test signals prior to transmission of received test signals back to the first transceiver. The first transceiver may determine path integrity characteristics based on the test signals transmitted from the second transceiver.
Patent DE-602004010613-T2 (DE)
Inventor: MUNDWILER ULRICH
IPC: A61C8/00
Filed: 2004-03-25
Granted: 2008-12-04
Abstract: The present invention relates to an intraosteal dental implant (1) having a bone tissue apposition surface (2) extending form a tip (1') of the dental implant (1) up to an interface (4) at a neck portion of the dental implant (1), and a soft tissue apposition surface (3) extending from the interface (4) to a shoulder (5) of the dental implant (1), wherein the shoulder (5) is inclined with respect to the axis (7) of the dental implant (1), and wherein preferably the shoulder (5) is substantially contained in a plane.
Patent DE-602005005560-T2 (DE)
Inventor: DROULEZ ERIC
IPC: B60H1/00
Filed: 2005-06-10
Granted: 2009-04-30
Abstract: The module has a partitioned case (3) made of e.g. powdered polypropylene, and delimiting a set of conduits allocated to zones of a cab interior. The case delimits an inlet channel (4) with respect to an air supply conduit. The channel has a main distributor (6) that selectively distributes air towards main distributing channels (7, 8), which are in communication with one of the zones of the cab interior. An independent claim is also included for a structuring unit of a cab interior of a motor vehicle.
Patent DE-68926751-T3 (DE)
Inventor: SMITS GEORGES
IPC: A23L27/30
Filed: 1989-03-09
Granted: 2003-02-06
Abstract: A powdery prod. contains at least 50% saccharose of apparent density 20-70 (25-50)% of that of commercial sugar powder, to which is added an amt. of additives comprising (partly of) sweeteners (I) of high sweetening power and opt. sweeteners (II) other than saccharose. Also claimed is prodn. of the prod. (II) comprise maltodextrins pref. obtd. by partial hydrolysis of an aq. starch soln., of ED 2-20. (I) comprise Aspartame, Acesulfame-K, Sucralose and Alitame (RTM's).
Patent DE-69023169-T3 (DE)
Inventor: CONTE UBALDO
IPC: A61K47/26
Filed: 1990-06-15
Granted: 2000-04-20
Abstract: The use of sucralfate humid gel is described as vehicle for the application of drugs having topic activity (dermic and mucosal) and as basis for the formulation of beauty masks and other cosmetic preparations. Therapeutic and cosmetic formulations are described in the form of creams, ointments, aqueous dispersions comprising sucralfate humid gel.
Patent DE-69833059-T3 (DE)
Inventor: SCHMIDT RICHARD A
IPC: A61P13/02
Filed: 1998-07-15
Granted: 2014-12-18
Abstract: The present application is directed to the use of a therapeutically effective amount botulinum toxin in the preparation of a pharmaceutical composition for treating a patient with a neurogenic bladder dysfunction, wherein the composition is to be administered by injection into a bladder wall of a patient with said neurogenic bladder dysfunction, thereby treating a symptom of said neurogenic bladder dysfunction.
Patent DK-1035127-T3 (DK)
Inventor: BRIEDEN WALTER DR
IPC: C07C25/13
Filed: 2000-03-09
Granted: 2003-11-03
Abstract: N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (I) is prepared by reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol (II) with chlorodiphenylphosphine (III).  Preparation of N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide of formula (I) comprises the reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol of formula (II) with (III).  Ph = phenyl; and  Ph' = 4-fluorophenyl.
Patent DK-1029953-T3 (DK)
Inventor: MARCHANDISE DIDIER
IPC: C23F1/30
Filed: 2000-02-03
Granted: 2003-10-27
Abstract: Deposition of polyaniline layer on titanium comprises electropolymerization after hydrofluoric/nitric acid pickling, chemical conversion treatment and hydrolysis.  Preferred Features: A titanium (alloy) substrate may be initially treated by alkaline degreasing for 10-15 minutes at 55-65 degrees C in a bath containing 36-44 g/l sodium tripolyphosphate (Na5P3O10), 40 g/l sodium tetraborate (Na2B4O7.10H2O), 10 ml/l Ref. 631 surfactant and sodium hydroxide to give pH 8.5-9.5 and by abrasive grit blasting to a surface roughness (Ra) of 10-30 mu m. The hydrofluoric/nitric acid pickling is carried out for 2-2.5 minutes at 18-22 degrees C in a bath containing 100-180 ml nitric acid (41 degrees Be), 40-60 ml hydrofluoric acid (48%), 1 g F68 additive, 1.5 g TA6V (metal) and 11 qsp distilled water. The deposit is baked at 40-160 degrees C for 30 minutes to 2 hours.
Patent DK-1261345-T3 (DK)
Inventor: GROSE TRICIA
IPC: A61K31/55
Filed: 2000-01-28
Granted: 2005-09-12
Abstract: Estrogen-deficiency related cognitive dysfunction may be improved by administering a composition comprising an herbal composition to a woman. In a preferred embodiment the herbal composition comprises whole plant extract of Leucojum aestivum.
Patent DK-1220796-T3 (DK)
Inventor: LUND CARSTEN
IPC: B65D43/02
Filed: 2000-09-14
Granted: 2004-03-08
Abstract: The invention relates to a packaging that is manufactured from a plastics material and comprises a container (50, 150) and a lid (10, 110), said container (50, 150) having an annular and upwardly open receiving channel (60, 160) for a part (34, 134) of the skirt (20, 120), arranged on the outside of the outer wall (54, 154) below a first engaging portion (58, 158), wherein the packaging has a third engaging portion (64, 164, 168') arranged in said receiving channel (60, 160) whereby the packaging obtains a fourth engaging portion (36, 136, 138) arranged on the skirt (20, 120) of the lid (10, 110) below a second engaging portion (28, 128), configured for establishing a snap-locking engagement with said third engaging portion (64, 164, 168') whereby the skirt (20, 120) between the second (28, 128) and the fourth (36, 136, 138) engaging portion comprises a peripheral weakening zone (42, 142) configured to allow, by rupture, separation of the skirt (20, 120) while maintaining said snap-locking engagement between the third (64, 164, 168') and the fourth (36, 136, 138) engaging portions.
Patent DK-1240782-T3 (DK)
Inventor: GUENEBAUD PHILIPPE
IPC: H04N21/4367
Filed: 2000-12-19
Granted: 2003-09-08
Abstract: The present invention relates to an interface module for a host ( 2 ) such as a digital television decoder, permitting the processing of information coming from the host ( 2 ) in a conditioned manner subject to a conditional access system ( 11 ), comprising authorization means ( 7 ) by which the user justifies his access rights. The module has at least one means ( 8 ) for identifying the authorization means ( 7 ); means ( 10 ) for storing a plurality of conditional access systems ( 11 ), processing means ( 9 ) adapted to process the information coming from the host ( 2 ) utilizing the conditional access system ( 11 ) corresponding to the authorization means ( 7 ) identified by the identification means ( 8 ), permitting to exploit a plurality of conditional access systems ( 11 ) within the same module The invention also relates to a decoder and a method adapted to be performed by the interface module For use in digital television decoders
Patent DK-1240805-T3 (DK)
Inventor: DABRINGHAUS WERNER
IPC: H04R5/02
Filed: 2000-12-16
Granted: 2004-08-16
Abstract: A method and an arrangement for recording and playing back sounds, especially music, is disclosed whereby stereo recording and playback techniques are at least partially used. The arrangement allows for a three-dimensional acoustic reproduction, especially music reproduction, that comes as close to a natural experience as possible. This is achieved by as least one 2+2+2 recording and playback technique and by means of a corresponding number of sound tracks for producing a sound impression which is realistic, three dimensional, and closely resembling nature in width, depth, and height.
Patent DK-1190731-T3 (DK)
Inventor: BATEMAN TIMOTHY
IPC: A61M16/04
Filed: 2001-08-23
Granted: 2006-12-27
Abstract: A ventilation device has a flexible adhesive sheet 1 that can be sealed around the patient's nose and mouth. A fitting 16 extending through the sheet in the region of the mouth enables the patient to be ventilated by means of a vent tube 17 inserted through the fitting. <IMAGE>
Patent DK-1244368-T3 (DK)
Inventor: BERGGREN SVANTE
IPC: A43B23/02
Filed: 2001-01-08
Granted: 2006-10-09
Abstract: The invention relates to an upper part for a shoe, in which the dimensional design of its inside and outside provides considerable adjustability through assembly with fastening devices positioned and construction in such a way that it gives a highly stable upper part, the characteristics of which in terms of material and properties permit is adaptation to different sizes of feet. The upper part of the shoe is in the form of woven fabric or some other flexible material, the fastening devices are in the form of hook and loop-type fastening devices such as VELCRO, at least some of which exhibit circular form, and the under side of the outside of the upper part of the shoe exhibits connecting devices essentially for its detachable attachment to a sole or other under part of the shoe capable of being placed in contact with a floor.
Patent DK-1293469-T3 (DK)
Inventor: DOBNER MATHIAS
IPC: B65G67/60
Filed: 2002-09-09
Granted: 2006-03-20
Abstract: Loading device (4) comprises two bridge supports (8) which are able to travel independently of one another across the longitudinal axis of the container bridge and parallel to each other. The supports each form a loading station (7.1, 7.2) for a container (6) and each support a container received by a platform (9) which rotates about a vertical axis. An Independent claim is also included for a method for operating the loading device. Preferred Features: Each loading station is moved by a moving mechanism (13) on a running strip or rail placed on the ground.
Patent DK-1304190-T3 (DK)
Inventor: CHEVALIER JEAN-PIERRE
IPC: B24D7/10
Filed: 2002-10-15
Granted: 2006-02-20
Abstract: The tool consists of a plate (10) with holes (11) and a series of angled cutting segments, each with a long (1) and a short (2) side and made from two layers (3, 4) of metal containing fine and coarser abrasive particles respectively. The forward-facing side of each segment is inclined at an acute angle (5) to the surface of the plate (10), and the segments are fitted in at least two different positions - one with their points parallel to the periphery of the plate, and the other with their short sides parallel to its edge.
Patent DK-1389537-T3 (DK)
Inventor: NAKAI MASANORI
IPC: B41M3/14
Filed: 2002-04-08
Granted: 2007-12-27
Abstract: After a first printed image (3) of gold ink is formed on a printing base, a second printed image (5) of a color ink is printed such that second single lines (6A) of microcharacter printing by the color ink in the second printed image (5) are superposed on first single lines (4A) in the image (3). The first printed image (3) includes a first background image (4) formed from the first single lines (4A) and second image lines (4B) and a first latent image (3A) (character "I"). The second printed image (5) includes a second background image (6) formed from the second single lines (6A) and a second latent image (5A) (character "O") formed by executing outline printing on the second background image (6). In a scattered light region, the first latent image (3A) can be visually recognized. In a regularly reflected light region, the second latent image (5A) can be visually recognized. Accordingly, the authenticity can be determined and the anti-forgery effect can be further increased. <IMAGE>
Patent DK-1392282-T3 (DK)
Inventor: GHISALBERTI CARLO
IPC: A61P17/08
Filed: 2002-05-15
Granted: 2008-06-09
Abstract: The present invention relates to a dermatological and/or cosmetic composition comprising a furfuryl derivative of formula (I), and its use in the treatment of dermatological disorders especially when caused by free radicals.
Patent DK-1534207-T3 (DK)
Inventor: LARSSON BJOERN
IPC: A61F13/15
Filed: 2002-05-27
Granted: 2007-07-30
Abstract: The invention relates to an absorbent product, such as a diaper, an incontinence pad or the like, which product comprises a liquid-permeable surface layer (2), a liquid-impermeable backing material (3) and an absorption body (4) enclosed between the surface layer (2) and the backing material (3), the product having a front portion (5), a rear portion (6) and a crotch portion (7) located between the front and rear portions, and an attachment system for securing the absorbent product on a wearer, the attachment system comprising at least one tab (18) for detachable interaction with a landing zone (20) arranged on the front or rear portion of the product, the landing zone being designed as a strip with two long sides (26) and two short sides (25) which join the two long sides (26) together, and the landing zone (20) comprising a central inactive area (28) arranged centrally in the transverse direction on the landing zone, and two active areas (27) arranged one on each side of the central inactive area (28) so that the active areas extend in the transverse direction from the central inactive area (28) to the short sides (25) of the landing zone.
Patent DK-1412428-T3 (DK)
Inventor: ASBAHR HARK-OLUF
IPC: C08L77/00
Filed: 2002-07-11
Granted: 2009-03-02
Abstract: A composition comprising a polyamide, 0.01% to 5% by weight of at least one primary antioxidant based on the total mass of the polyamide, and at least one secondary antioxidant.
Patent DK-1440151-T3 (DK)
Inventor: WANG QI
IPC: C12N15/82
Filed: 2002-09-05
Granted: 2008-06-30
Abstract: This invention provides promoters capable of transcribing heterologous nucleic acid sequences in seeds, and methods of modifying, producing, and using the same.
Patent DK-1458855-T3 (DK)
Inventor: SPITS HERGEN
IPC: C12N15/09
Filed: 2002-12-18
Granted: 2012-07-23
Abstract: The invention provides methods for maintaining cell lines from primary cells, i.e. non-transformed cells, using expression of the signal transducer of activation and transcription (STAT). The methods are particularly suitable for the maintenance of B-cells.
Patent DK-1429808-T3 (DK)
Inventor: PRATO TIZIANO
IPC: A61K47/46
Filed: 2002-07-26
Granted: 2010-07-19
Abstract: The invention relates to a composition of spores of nonpathogenic bacteria of the Bacillus genus, adsorbed onto a matrix made up of at least one water-insoluble adsorbent compound and a cellulose derivative, which can be obtained by the fluidized air bed technique, useful in the pharmaceutical, veterinary and nutrition fields.
Patent DK-1430913-T3 (DK)
Inventor: SCHILKE FRANK DIPL-CHEM
IPC: A61L31/00
Filed: 2003-10-17
Granted: 2008-08-25
Abstract: The bone cement has a fixed X-ray contrast medium. The X-ray contrast medium is functionalized by methacrylate group and a chemical bonding takes place with the surrounding polymer of the hardened bone cement. The X-ray contrast medium has inorganic filling material, zirconium oxide, barium sulphate, bismuth and iodine containing contrast medium. The medium has a covering with a melamine resin as a reactive interface layer. The X-ray contrast medium manufacturing method involves washing and drying with melamine formaldehyde resin layer and addition of methacryl acid chloride.
Patent DK-1453358-T3 (DK)
Inventor: CHALUPPER JOSEF
IPC: H04R25/00
Filed: 2004-02-16
Granted: 2008-01-21
Abstract: The method involves analyzing a first hearing aid (1) and providing an analysis result, determining setting parameters for the second hearing aid (3) based on the analysis results for the first hearing aid and adjusting the second hearing aid based on the determined adjustment parameters. The automatic analysis includes providing an input signal and examining an associated output sound signal at the first hearing aid. An independent claim is also included for the following: (a) an arrangement for automatically adjusting a second hearing aid .
Patent DK-1428820-T3 (DK)
Inventor: SCHWARTZ JEAN-CHARLES
IPC: A61K31/4453
Filed: 1999-07-29
Granted: 2006-08-28
Abstract: The present invention provides new non-imidazole alkylamine derivatives, and their use for preparing medicaments acting as ligands at the H 3 -receptors of histamine.
Patent DK-1597499-T3 (DK)
Inventor: MCCAUSLAND ANDREW JOHN
IPC: F16K7/10
Filed: 2004-02-27
Granted: 2010-04-12
Abstract: A bladder valve ( 10 ) is disclosed which comprises a valve body ( 12 ) having an inlet ( 16 ), an outlet ( 14 ) and a flow passage ( 17 ) connecting the inlet ( 16 ) and the outlet ( 14 ). The bladder valve ( 10 ) also includes a valve seat ( 45 ) surrounding the flow passage ( 17 ) and an inflatable bladder ( 22 ) mounted in the flow passage ( 17 ) and being connectable to a source of fluid under pressure in use. The bladder ( 22 ) is mounted on a bladder support member ( 34 ) which provides support for the bladder when in its deflated condition, and through which inflation passages ( 42 ) pass for the inflation and deflation of the bladder. The bladder ( 22 ) is designed to collapse or deflate rapidly in order to open the valve, enabling the valve to be used in applications such as reverse pulse cleaning of filter elements.
Patent DK-1684775-T3 (DK)
Inventor: CHATTERJEE SHYAM SUNDER
IPC: A61K36/185
Filed: 2004-10-26
Granted: 2008-06-16
Abstract: The use of extracts or parts of Pelargonium species plants is claimed in the prophylaxis and/or treatment of disease-associated behavioral changes and/or chronic and/or post-viral fatigue syndrome, is new. ACTIVITY : Immunomodulator; Antidepressant; CNS-Gen.; Eating-Disorders-Gen.; Muscular-Gen.; Hypnotic; Tranquilizer; Analgesic. MECHANISM OF ACTION : None given. A dry extract (I) of Pelargonium sidoides roots (obtained in 11% yield by macerating the roots twice with a 7-fold amount of 11 wt.% ethanol at 55 [deg]C) was administered orally to mice, followed an hour later by intraperitoneal injection of lipopolysaccharide (LPS) at 400 Microg/kg. The mice were subjected to exploration behavioral tests for 3 minutes in a light-dark box. The average time spent in the light area was 83 seconds for vehicle-only controls, 134 seconds after treatment with LPS only, 119 seconds after treatment with LPS plus (I) at 100 mg/kg, 104 seconds after treatment with LPS plus (I) at 200 mg/kg and 97 seconds after treatment with LPS plus (I) at 100 mg/kg. (I) thus caused dose-dependent inhibition of LPS-induced behavioral changes.
Patent DK-1586580-T3 (DK)
Inventor: KELLEHER THOMAS J
IPC: A61K38/08
Filed: 2001-01-18
Granted: 2010-03-29
Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of  Streptomyces roseosporus.  The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Patent DK-1666052-T3 (DK)
Inventor: ASHKENAZI AVI J
IPC: A61P25/00
Filed: 2000-11-28
Granted: 2011-09-12
Abstract: Methods of using one or more agonists to modulate activity of he members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA are provided. The methods include  in vitro, in situ , and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with TALL-1, APRIL, TACI, or BCMA, using one or more agonist or antagonist molecules. The methods of treatment disclosed by the invention include methods or treating immune related diseases and cancer.
Patent DK-1725258-T3 (DK)
Inventor: CONTORNI MARIO
IPC: A61K39/12
Filed: 2005-03-14
Granted: 2010-11-01
Abstract: Provided herein are combination vaccines comprising antigens for protecting a subject against at least diphtheria, tetanus, pertussis and Hib, wherein: (a) the antigen for protecting against Hib is a conjugate of a Hib capsular saccharide; (b) the concentration of the Hib conjugate in the vaccine is <15 μg/ml; and (c) the Hib conjugate has never been lyophilized.