Patent SG-11201809501P-A (SG)
Title: Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
Inventor: CARRANCIO SORAYA
IPC: A61P35/02
Filed: 2017-06-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111011101111111101011111001111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/214014 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: Stevenson Street, San Francisco, CA 94103 (US). POUR- A61K 31/454 (2006.01) A61P 35/02 (2006.01) DEHNAD, Michael; 3972 26th Street, San Francisco, CA (21) A61K 31/4545 (2006.01) 94131 (US). RAPPLEY, Irit; 2645 Gobat Avenue, San Diego, CA 92122 (US). International Application Number: PCT/US2017/035892 (74) Agent: BHUMRALKAR, Megha et al.; Jones Day, 250 (22) International Filing Date: Vesey Street, New York, NY 10281-1047 (US). 05 June 2017 (05.06.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/346,344 06 June 2016 (06.06.2016) US HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (71) Applicant: CELGENE CORPORATION [US/US]; 86 MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Morris Avenue, Summit, NJ 07901 (US). PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (72) Inventors: CARRANCIO, Soraya; 5205 Fiore Terrace, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Apt. B419, San Diego, CA 92122 (US). HOLLENBACH, Paul; 20793 Gleenwood Drive, Castro Valley, CA 94552 (84) Designated States (unless otherwise indicated, for every — (US). LOPEZ-GIRONA, Antonia; 8959 January Place, kind of regional protection available): ARIPO (BW, GH, San Diego, CA 92122 (US). MACBETH, Kyle; 1356 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = (54) Title: TREATMENT OF A HEMATOLOGIC MALIGNANCY WITH 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPI _ _ PERIDIN-3-YL)-1-0X0ISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE _ = Counts FamA = = = 0 _ = = = 0 = 1 l Fain C 1000 = = _ = = = = 15C0 ' — 1tI = T -- T T - r - T - T - r - I TT I T T\" T T Y T T \"T\" T ri \"I T T 1 T - T - 1\" T - 1\" - 7 .- I T 7 . T - 3 - 7 - 1 ---- r - r - _ 0 20 30 1-1 P nihata] Copper (CO 7r 11 0 FIG. 1 71- 1-1 ei ---- (57) : Provided herein are methods of treating, preventing, managing, and/or ameliorating leukemia or myelodysplastic IN syndrome comprising administering 2-(4-chlorophenyl)-N-((2-(2,6- dioxopiperidin-3-y1)-1-oxoisoindolin-5-yOmethyl)-2,2-difluoroac © etamide or a stereoisomer or mixture of stereoisomers, an isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, N co -crystal, clathrate, or polymorph thereof to a patient. O [Continued on next page] WO 2017/214014 Al MIDEDIMOMOIDEIRMEM0011010HOIROEHIMEMOIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))