Patent SG-11201407402T-A (SG)
Title: Carbazole-containing sulfonamides as cryptochrome modulators
Inventor: BERSOT ROSS
IPC: C07D493/08
Filed: 2013-05-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/170186 A1 (51) International Patent Classification: C07D 403/12 C07D 405/14 C07D 401/06 C07D 401/12 C07D 403/06 C07D 405/12 C07D 409/12 C07D 413/12 (2006.01) C07D417/06 (2006.01) (2006.01) C07D 493/08 (2006.01) (2006.01) C07D 209/86 (2006.01) (2006.01) C07D 209/88 ( 2006.01) (2006.01) A61K31/403 (2006.01) (2006.01) A61P 3/00 (2006.01) (2006.01) A61P 25/00 (2006.01) (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/040604 10 May 2013 (10.05.2013) English English (30) Priority Data: 61/645,918 61/778,176 11 May 2012 (11.05.2012) US 12 March 2013 (12.03.2013) US (71) Applicant: RESET THERAPEUTICS, INC. [US/US]; 863a Mitten Road, Suite 100c, Burlingame, CA 94010 (US). (72) Inventors: BERSOT, Ross; C/o Bay City Capital, 750 Battery Street, Suite 400, San Francisco, CA 94111 (US). HUMPHRIES, Paul; C/o Bay City Capital, 750 Battery Street, Suite 400, San Francisco, CA 94111 (US). (74) Agents: ELRIFI, Ivor, R. et al.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.c., Chrysler Center, 666 Third Av­ enue, New York, NY 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS 00 T-H o l> G' \ \" 3 H^TN' R4 0H/S A <r 0 B-VC (R ) 2 b R( (i) i-H (57) Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically accept- O able salts or hydrates thereof of structural formula wherein I the variable Ri, R , 2 R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b CJ are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry- Q mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.