Patent SG-11201908423R-A (SG)
Title: Optical probe, raman spectroscopy system, and method of using the same
Inventor: OLIVO MALINI
IPC: G01N21/65
Filed: 2018-03-29
Abstract: WO 18/ 18 25 37 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit VIII °nolo onololiolloommo oimIE (10) International Publication Number WO 2018/182537 Al (51) International Patent Classification: GO1J 3/44 (2006.01) GO1N 21/65 (2006.01) (21) International Application Number: PCT/SG2018/050166 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201702588T 30 March 2017 (30.03.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: OLIVO, Malini; c/o Singapore Bioimaging Consortium (SBIC), 11 Biopolis Way, #01-02 Helios, Sin- gapore 138667 (SG). SINGH, Gurpreet; c/o Singapore Bioimaging Consortium (SBIC), 11 Biopolis Way, #01-02 Helios, Singapore 138667 (SG). BI, Renzhe; c/o Singa- pore Bioimaging Consortium (SBIC), 11 Biopolis Way, #01-02 Helios, Singapore 138667 (SG). DEV, Kapil; c/ o Singapore Bioimaging Consortium (SBIC), 11 Biopo- lis Way, #01-02 Helios, Singapore 138667 (SG). UNNI- MADHAVA KURUP SOUDAMINI AMMA, Dinish; c/ o Singapore Bioimaging Consortium (SBIC), 11 Biopolis Way, #01-02 Helios, Singapore 138667 (SG). HO, Jun Hui, Chris; c/o Singapore Bioimaging Consortium (SBIC), 11 Biopolis Way, #01-02 Helios, Singapore 138667 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: OPTICAL PROBE, RAMAN SPECTROSCOPY SYSTEM, AND METHOD OF USING THE SAME (57) : Provided is an optical probe, and a Raman spectroscopy system 122 using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically cou- pled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Ra- man spectra is measured and stored at different focal plane positions. FIG. 1 [Continued on next page] WO 2018/182537 Al MIDEDIMOIMEMIHINOME101110110EIHMEMOIS EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))