baber/WOPTO huggingface dataset:
Patent DK-0530265-T3 (DK)
Inventor: RICHARD L
IPC: C07K16/28
Filed: 1991-05-08
Granted: 1999-06-14
Abstract: This invention provides isolated nucleic acid molecules encoding human 5-HT1D receptors, isolated proteins which are human 5-HT1D receptors, vectors comprising isolated nucleic acid molecules encoding human 5-HT1D receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1D receptors, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1D receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT1D receptor, pharmaceutical compounds related to human 5-HT1D receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT1D receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT1D receptor.
Patent DK-0551558-T3 (DK)
Inventor: BORN PETER
IPC: B65B13/18
Filed: 1992-05-30
Granted: 1995-04-18
Abstract: In a labelling system for stacks of articles on pallets, a printer (4) for printing the labels and a conveyor device (10) for conveying the printed labels to the string (1) provided for tying the stack are provided. The printer (4) is suitable for the printing of non-folded normal paper (6). To fold the paper sheets (6) to form labels, a folding device (8) is arranged between the printer (4) and the conveyor device (10). <IMAGE>
Patent DK-0508699-T3 (DK)
Inventor: SALZMANN THOMAS N
IPC: A61P31/04
Filed: 1992-04-03
Granted: 1998-05-04
Abstract: Compounds of the formula: <CHEM> where R is hydrogen, hydroxyl, alkyl or acyl, R min  and R sec together are oxo, hydroxyimino or alkoxyimino, and R min  and R sec independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.
Patent DK-0605482-T3 (DK)
Inventor: CLAESSON KNUT
IPC: F24F3/14
Filed: 1992-08-25
Granted: 1995-09-11
Abstract: PCT No. PCT/SE92/00585 Sec. 371 Date Jan. 12, 1994 Sec. 102(e) Date Jan. 12, 1994 PCT Filed Aug. 25, 1992 PCT Pub. No. WO93/04764 PCT Pub. Date Mar. 18, 1993.A method and apparatus for increasing the yield of an air-drying process with the aid of a dehumidifier 2 and a condenser/heat-exchanger 3 involves delivering wet regenerating air exiting the dehumidifier to one side of the condenser/heat-exchanger so as to deliver energy to the process air entering the other side. Condensation deriving from the regenerating air is collected and carried away, and the heated, dried process air 21 is delivered to the dehumidifier in which moisture is extracted from the air and the air further dried. The departing wet regenerating air may, after its delivery process, be led to the room, atmosphere or the flow of process air.
Patent DK-0606261-T3 (DK)
Inventor: HAMILTON PETER WORTHINGTON
IPC: B65D50/04
Filed: 1992-08-27
Granted: 1996-05-20
Abstract: A package for storing and dispensing potentially dangerous materials, such as medicament tablets or the like, said package being resistant to opening by children but readily openable by adults, particularly adults having impaired manual dexterity of their hands and/or fingers. In a particularly preferred embodiment, the package comprises a bottle (12), a collar (32) which is secured in place over the uppermost portion of the bottle (12) and a closure (52) which is secured to the finish portion of the bottle by means of complementary screw threads. The collar (32) preferably includes a pair of resiliently deformable spring-like pushtabs (34) containing vertical extensions (36) which engage interlocking teeth (62) on the innermost surface of the closure skirt (60) when the closure (52) is fully assembled onto the bottle (12). To remove the closure (52), the opposed pushtabs (34) must be manually depressed prior to applying unscrewing torque to the closure (52) to disengage the pushtab extensions (36) from the interlocking teeth (62) on the closure (52). In a particularly preferred embodiment, the spring-like pushtabs (34) are generally outwardly directed prior to application of the closure to the package. Advancing the closure (52) onto the package until the teeth (62) on the innermost surface of the closure's skirt (60) interlock with the vertical extensions (36) of the spring-like pushtabs (34) causes a degree of resilient deformation of the spring-like pushtabs (34) so that the vertical extensions (36) of the pushtabs (34) are in contact with and exert a preloading force against the corresponding innermost surfaces of the closure skirt once the closure has been securely applied to the package. Quite unexpectedly, it has been learned that preloading the vertical extensions of the reiliently deformable spring-like pushtabs against the corresponding innermost surfaces of the closure skirt in the foregoing manner considerably enhances the child resistance of the package without increasing the difficulty of opening for older adults or those having impaired manual dexterity. Methods for producing the improved package are also disclosed.
Patent DK-0588578-T3 (DK)
Inventor: BECKER ROBERT S
IPC: A61K/
Filed: 1993-09-13
Granted: 2000-03-27
Abstract: An immunogen for eliciting an immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the haemagglutinin antigen (HA) from influenza virus contains the antigen in two different physio-chemical forms. The immunogen may comprise one composition containing the two antigen forms or there may be two compositions containing respective antigen forms. Administration of the immunogen to an animal at one or more sites gives an enhanced immune response compared to the immunogen comprising only one of the two antigen forms.
Patent DK-0589807-T3 (DK)
Inventor: EHRSTROEM JEAN-CHRISTOPHE
IPC: C22F1/00
Filed: 1993-09-20
Granted: 1999-03-22
Abstract: Alloy of the 7000 series and a specific heat treatment with a view to the manufacture of hollow bodies under pressure and, in particular, of metal bottles for compressed gases. The alloy contains, in weight %:  6.25 </= Zn </= 8.0  Mn </= 0.20  1.2 </= Mg </= 2.2  Ti </= 0.05  1.7 </= Cu </= 2.8  0.10 </= Zr </= 0.25  others, each </= 0.05  Fe </= 0.20  '' total </= 0.15  Si+Fe </= 0.40  remainder: Al  Cr </= 0.05. The final annealing is preferably performed in 3 stages:     - 1st stage between 105 and 120 DEG C for 6 to 12 h   - 2nd stage: between 170 and 190 DEG C for 0.5 to 20 h - 3rd stage: between 105 and 120 DEG C for 12 to 36 h.
Patent DK-0640595-T3 (DK)
Inventor: YODEN TORU
IPC: C07D253/07
Filed: 1993-04-27
Granted: 1999-10-11
Abstract: A substituted tertiary amino compound represented by general formula (I) or a pharmaceutically acceptable salt thererof. They have an aromatase inhibiting activity and are useful as a prophylactic and/or therapeutic agent for breast cancer, mastopathy, endometriosis, prostatic hypertrophy, and so forth. <CHEM>
Patent DK-0666731-T3 (DK)
Inventor: IBSEN ROBERT L
IPC: A61K8/46
Filed: 1993-10-26
Granted: 2004-10-18
Abstract: An antibacterial oral hygiene composition in aqueous form comprising: (a) from about 0.05% to about 0.2% by weight of sodium benzoate; (b) from about 0.01% to about 1.0% by weight of a weak carboxylic acid; (c) from about 2.0% to about 5.0% by weight of a buffering agent capable of buffering the composition to a pH of about 3.0 to about 8.0; (d) from 0% to about 1.5% by weight of a surfactant; (e) from 0% to about 0.2% by weight of sodium saccharin, or an amount sufficient to provide a sweetening effect equivalent thereto of a sweetening agent; (f) from 0% to about 2.0% by weight of a flavoring agent; and (g) sufficient water to total 100%.
Patent DK-0724811-T3 (DK)
Inventor: FENOUIL REMY L
IPC: H04N7/14
Filed: 1994-10-18
Granted: 2000-12-18
Abstract: A method for the simultaneous transmission of analogue video and digital data signals on a standard twisted pair cable having four pairs of wires, comprising the steps of transmitting an analogue video signal to a frequency coupler, transmitting a digital data signal to a frequency shift key modulator, which puts the digital data signal onto an analogue data signal, which analogue data signals are passed to the said frequency coupler, which combines said video and data signals. The combined signal is then routed to a first pair of wires, a high speed digital data signal is carried on a second pair of wires, said first and second twisted pair of wires being in the same twisted pair cable
Patent DK-0666314-T3 (DK)
Inventor: COLICELLI JOHN J
IPC: C12N15/55
Filed: 1991-04-19
Granted: 2001-12-10
Abstract: Disclosed are methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the microorganism. Disclosed also are mammalian DNA sequences cloned by the above method, as well as polypeptide products of the expression of the DNA sequences in procaryotic or eucaryotic host cells and antibody substances which are specifically immunoreactive with said expression products. More specifically, the present invention relates to methods for cloning mammalian genes which encode products which modify, complement or suppress a genetic defect in a biochemical pathway in which cAMP participates to products (RNA, proteins) encoded by the mammalian genes cloned in this manner, and to antibodies which can bind the encoded proteins.
Patent DK-0742725-T3 (DK)
Inventor: KARLSSON HANS
IPC: A61M1/14
Filed: 1995-02-01
Granted: 2003-04-14
Abstract: PCT No. PCT/SE95/00095 Sec. 371 Date Jul. 31, 1996 Sec. 102(e) Date Jul. 31, 1996 PCT Filed Feb. 1, 1995 PCT Pub. No. WO95/20983 PCT Pub. Date Aug. 10, 1995A microdialysis probe having a center tube surrounded by a thin dialysis tube (3), which is located between two tubular fitting parts (2, 5). With the purpose of reinforcing the probe and facilitating its withdrawal without any part of the probe remaining despite the fragility of the dialysis tube, the distal end of the center tube from within is fixedly joined to the distal fitting part (2), which also has a larger diameter than the dialysis tube (3).
Patent DK-0791056-T3 (DK)
Inventor: OPITZ HANS-GEORG
IPC: A61K47/48
Filed: 1995-11-09
Granted: 2005-07-04
Abstract: A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in-vitro research systems containing this enzyme used to detect other substrates of this enzyme.
Patent DK-0800657-T3 (DK)
Inventor: CHABRECEK PETER
IPC: G02B1/10
Filed: 1995-12-27
Granted: 1999-08-09
Abstract: PCT No. PCT/CH95/00309 Sec. 371 Date Sep. 12, 1997 Sec. 102(e) Date Sep. 12, 1997 PCT Filed Dec. 27, 1995 PCT Pub. No. WO96/21167 PCT Pub. Date Jul. 11, 1996The invention relates to crosslinked polymers, which are polymerisation products of a polymerisable mixture that comprises the following components: a) a macromer of formula C  wherein Macro is an m-valent radical of a macromer from which the number m of groups Rxx-H has been removed, each Rx, independently of the others, is a bond, -O-, -NRN- or -S- wherein RN is hydrogen or lower alkyl, PI* is a bivalent radical of a photoinitiator, Raa is the moiety of a photoinitiator that forms the less reactive free radical on cleavage of the photoinitiator, and m is an integer from 1 to 100, b) a copolymerisable vinyl monomer and c) a copolymerisable crosslinker. The polymers are suitable especially for the production of mouldings, such as for contact lenses.
Patent DK-0792149-T3 (DK)
Inventor: GAMBHIR RENU
IPC: A61K31/415
Filed: 1995-11-20
Granted: 2000-12-18
Abstract: PCT No. PCT/IB95/01152 Sec. 371 Date Jul. 9, 1997 Sec. 102(e) Date Jul. 9, 1997 PCT Filed Nov. 20, 1995 PCT Pub. No. WO96/15786 PCT Pub. Date May 30, 1996The invention relates to a liquid composition for oral administration comprising ondansetron or a pharmaceutically acceptable derivative thereof, a sweetener and one or more pharmaceutically acceptable excipients. The sweetener comprises one or more polyhydric alcohols and the pH of the combination lies in the range 2.0 to 5.0. Methods for the manufacture of such compositions and for their use in the treatment of conditions mediated through the action of 5-hydroxytryptamine (5 HT) at 5 HT3 receptors are also included.
Patent DK-0762038-T3 (DK)
Inventor: WENDORFF ERNST
IPC: F16L47/14
Filed: 1996-08-09
Granted: 2002-04-15
Abstract: The pipe (6,7) connector (1) has a basic body block (2) with connection surfaces (3,4,5) for the flanges or bosses of connecting tubes (6,7). The body (2) is made of, or contains a crosslinked plastic. Pref. this is one of: polyethylene (PE), polyacetal, phenolic resin, unsatd. polyester resin or crosslinked SMC. A fibre reinforced plastic may be used. The body is made from solid material and after forming. it is irradiatively crosslinked. Pref. it is injection moulded and irradiatively crosslinked after moulding. Chemical crosslinking may be applied. The body has a bored passage (8) with flange or boss connection surfaces (4,5) on both sides.
Patent DK-0815856-T3 (DK)
Inventor: MUELLER RICHARD AUGUST
IPC: C07C215/28
Filed: 1991-11-18
Granted: 2005-10-03
Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Patent DK-0811741-T3 (DK)
Inventor: SCHMIDT KARL HEINZ
IPC: E05D15/10
Filed: 1997-05-09
Granted: 2002-03-04
Abstract: The sliding door has a control arm (27) which is formed relative to its pivotable joint (29) on the fixed base (17, 17a) as a three-armed lever (62-64). One lever arm (62) of the control arm grips the extension arm (20). The other two lever arms (63,64) are assigned to the drive and positioning cam (33) in two different control curve regions (67,68). The two regions are set at different height levels and partially in different longitudinal sections (67a,67b,68a-c).
Patent DK-0805126-T3 (DK)
Inventor: GARNIER JEAN-FRANCOIS
IPC: C03C17/04
Filed: 1997-04-30
Granted: 2001-10-01
Abstract: In a glass panel comprising a glass sheet (1) having one or more rough surface zones (4) provided with a frit-based coating, the roughness of the or each rough zone (4) is determined by the particles of the base frit. The panel may have several rough zones, which cover part (preferably 50%) of the glass sheet surface (2) and which are uniformly or irregularly distributed, or may have a single rough zone which covers the entire sheet surface. Also claimed is a process for producing the above panel by (a) depositing a medium onto the glass sheet (1) in the or each zone in which roughness is required; (b) distributing the coating constituent particles (mainly base glass frit) onto the glass sheet; (c) removing excess particles which are not adhered by the medium; and (d) heat treating especially to soften and adhere the frit particles to the glass sheet. Further claimed is a base glass frit for use in the above process, the frit having an average firing temperature which is  NOTGREATER  100 (preferably 70) degrees C below the heat treatment temperature of the glass sheet and preferably containing (by wt.) 50-70% PbO, 5-10% CdO, 25-50% SiO2, 2.5-5% B2O3, 2.5-5% TiO2 and 2.5-5% Na2O.
Patent DK-0893669-T3 (DK)
Inventor: WHELAN MAURICE
IPC: G01B11/16
Filed: 1997-07-21
Granted: 2002-10-07
Abstract: A device for measuring the deformation of a mechanical test specimen, and including a pressing member (3) for stressing a substantially flat specimen (16) in controlled manner by means of a punch (25); a Michelson interferometer having an optical branch (9d) defined optically by a first face (16b) of the specimen (16), and for generating interference images related to the deformation of the specimen (16); a telecamera (44) for acquiring and digitizing the interference images; and a processor (27) for processing the digitized images and controlling the measuring process fully automatically. The interferometer (9) may alternatively perform white light interferometry measurements, ESPI measurements, or ESPI profilometry measurements, by simply substituting the light source and control software. <IMAGE>
Patent DK-0932609-T3 (DK)
Inventor: STACK GARY PAUL
IPC: A61K31/454
Filed: 1997-10-10
Granted: 2003-09-01
Abstract: The compounds of formula (I) wherein X is H2 or O; R<1> is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesulfonamido; Z is defined by formula (II), (III) or (IV) wherein R<2> is hydrogen, alkyl, cycloalkyl, phenyl optionally substituted with R<1> as defined above,  omega -phenylalkyl or  omega -diphenylalkyl, in which the phenyl ring is optionally substituted with R<1> as defined above, or R<2> is naphthyl, indolyl, indazolyl, thienyl, pyridinyl, pyrimidinyl, quinolinyl, benzoisothiazolyl or benzisoxazolyl, each optionally substituted with R<1> as defined above; R<3> is hydrogen and R<4> is hydrogen, 1-benzimidazolyl-2-one, indolyl, benzoisothiazolyl or benzisoxazolyl, each optionally substituted with R<1> as defined above, or R<4> is -Y-Ar, in which Y is C=O, CHOH, or (CH2)m, wherein m is 0 to 4, and Ar is phenyl, optionally substituted with R<1> as defined above; or R<3> and R<4>, taken together with the carbon atom to which they are attached form (V) or (VI) in which R<5> is hydrogen and R<6> is phenyl, naphthyl, thienyl, indolyl, benzoisothiazolyl or benzisoxazolyl, each optionally substituted with R<1> as defined above; or R<5> and R<6>, taken together with the carbon atoms to which they are attached complete a benzene ring optionally substituted with R<1>; or a pharmaceutically acceptable salt thereof; are useful for the treatment of brain dopamine dysregulation.
Patent DK-0916046-T3 (DK)
Inventor: MADSEN KARSTEN SCHACK
IPC: F16K1/44
Filed: 1997-05-28
Granted: 2003-02-10
Abstract: PCT No. PCT/EP97/02779 Sec. 371 Date Dec. 16, 1998 Sec. 102(e) Date Dec. 16, 1998 PCT Filed May 28, 1997 PCT Pub. No. WO98/54493 PCT Pub. Date Dec. 3, 1998The invention relates to a double-seat valve, particularly for aseptic applications, having at least two line connections (3, 4, 7), between which two annular valve seats (11, 12) are disposed coaxially with one another and in series, having two closers (8, 9), which are axially closable independently of one another and which in the closed state cooperate sealingly with the valve seats (11, 12) and between them enclose a hollow chamber (34), and having at least one cleaning connection (35, 36), discharging into the hollow chamber (34), for introducing a cleaning medium. To overcome the disadvantages of a fluidically unfavorable leakage hollow chamber, it is provided according to the invention that a one-piece, annularly encompassingly designed elastic sealing element (21) is secured sealingly in each case by its two end portions (22, 23) to the two closers (8, 9), with one sealing face (25, 26) embodied adjacent to each end portion (22, 23), the sealing face being pressable by a closer (8, 9) against the associated valve seat (11, 12), and that the sealing element (21) has a roller diaphragm portion (24), which connects the two end portions (22, 23) to one another and defines the hollow chamber (34).
Patent DK-0863125-T3 (DK)
Inventor: GEWALD RAINER DR
IPC: C07C69/675
Filed: 1998-02-25
Granted: 2002-02-25
Abstract: Preparation of 3-hydroxyoctanedicarboxylic acid diesters of formula (S)-1 and (R)-1 comprises asymmetric hydrogenation of ketones (III): R1, R2 = 1-20C alkyl, 3-12C cycloalkyl, 7-12C aralkyl or a mono- or bicyclic aryl group. The hydrogenation takes place in the presence of a ruthenium-diphosphine complex.
Patent DK-0898893-T3 (DK)
Inventor: FREY ALBERT
IPC: A22C11/08
Filed: 1998-08-13
Granted: 2003-03-24
Abstract: The two sausage filling machines are supplied with sausage meat from a common funnel with two outlets. The funnel is shaped like a figure eight having rotor blades on each side to drive the sausage meat downwards from a single central meat insertion point.
Patent DK-1019453-T3 (DK)
Inventor: BENSON SCOTT CONRAD
IPC: C07H19/04
Filed: 1998-09-18
Granted: 2004-08-02
Abstract: A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having general structure (I), where Y1 and Y2 taken separately are selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Y1 taken together with R2 is cyclic imine, or Y2 taken together with R3 is cyclic amine; R2, R3, R5, and R7 taken separately are selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, imminium, amido, nitrile, lower alkoxy, phenyl, and linking group; R1 taken separately is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, linking-group and electron-rich heterocycle, or when taken together with R7 is selected from the group consisting of electron-rich heterocycle and indene; R4 taken separately is selected from the group consisting of amino, amido, phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, linking group and electron-rich heterocycle, or when taken together with R5 is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, and electron rich heterocycle; and R6 is selected from the group consisting of acetylene, lower alkyl, lower alkene, cyano, phenyl, substituted phenyl, and heterocyclic aromatic. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labelled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilising such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods. <CHEM>
Patent DK-1035841-T3 (DK)
Inventor: KOTHRADE STEPHAN
IPC: A23L33/10
Filed: 1998-11-30
Granted: 2002-09-02
Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.