Patent SG-11201811755P-A (SG)
Title: A wound healing composition
Inventor: VARDY LEAH
IPC: A61K31/132
Filed: 2017-07-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) W I PO I PCT mu °million °nolo olon Ho Em loollimio oimIE (10) International Publication Number WO 2018/004467 Al (51) International Patent Classification: A61K 31/132 (2006.01) A61K 31/198 (2006.01) A61K 31/7076 (2006.01) A61P 17/02 (2006.01) (21) International Application Number: PCT/SG2017/050336 (22) International Filing Date: 03 July 2017 (03.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201605436U 01 July 2016 (01.07.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: VARDY, Leah; c/o Institute of Medical Biol- ogy, 8A Biomedical Grove, #06-06 Immunos, Singapore 138648 (SG). LIM, Hui Kheng; c/o Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, Singa- pore 138648 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) 1-1 N (54) Title: A WOUND HEALING COMPOSITION 71' 71' (57) : Disclosed herein are pharmaceutical compositions comprising at least one polycationic aliphatic amine, in particular spermidine, spermine or a combination thereof. The compositions can further comprise one or more selected from decarboxylated 5- adenosylmethionine and an inhibitor of ornithine decarboxylase 1 (ODC1 ) such as difluoromethyl ornithine (DFMO). Also disclosed herein are methods of determining the presence of a type of wound and methods for treating the same, i.e. acute or non-healing wounds, 1-1 © which in a particular embodiment, comprises determining the ratio of putrescine versus spermidine/spermine. The present disclosure f'1 also includes methods promoting re-epithelialisation of wounds and pharmaceutical compositions for the same use.