baber/WOPTO huggingface dataset:
Patent RS-20050522-A (RS)
Title: Protein kinase inhibiting tricyclic compounds that increase the effects of anti-neoplastic agents and therapeutic radiation
Inventor: NINKOVIC SACHA
IPC: C07D487/06
Filed: 2004-01-05
Abstract: Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R2, R3 and R4 are as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions, such as cancers.
Patent DO-P2011000135-A (DO)
Title: Moduladores de aril metil benzoquinazolinona alostericos positivos del receptor m1
Inventor: KUDUK SCOTT D
Filed: 2011-05-12
Abstract: La presente invención se refiere a compuestos de benzoquinazilinona de fórmula (I) Ios cuales son moduladores alostéricos positivos del receptor M1 y que son útiles en el tratamiento de enfermedades en las que el receptor M 1 está implicado, tales como enfermedad de Alzheimer, esquizofrenia y trastornos por dolor o del sueño. La invención también se refiere a composiciones farmacéuticas que comprenden Ios compuestos y aI uso de Ios compuestos y composiciones en eI tratamiento de enfermedades mediadas por el receptor M1.
Patent DO-P2020000148-A (DO)
Title: Inhibidores de cd73
Inventor: YAN WANG
IPC: C07D403/04
Filed: 2020-07-28
Abstract: La presente invención proporciona 5-[5]-[2-cicloalquil]-6-piridazin-3-il]-1H-pirimidin-2,4-diona, o sales aceptables desde el punto de vista farmacéutico de este, que inhiben la actividad de CD73 y son útiles en el tratamiento contra el cáncer.
Patent EC-SP10010212-A (EC)
Inventor: ZAGLIO SERGIO
IPC: A47G25/14
Filed: 2010-05-28
Abstract: The present invention relates to a multifunction machine for laundries, which comprises a body or frame (11) defining a treatment chamber (12) hermetically closed and equipped with means (15) for hanging elements (14), such as bed linen, clothes and garments, to be treated; means for removing stains, a wash and rinse; means for drying; and means for ironing said elements while they are hanging and stretched out in said treatment chamber.
Patent EC-SP13012853-A (EC)
Title: Herramienta de montaje
Inventor: WATSON BROCK W
IPC: E21B33/12
Filed: 2013-08-26
Abstract: Se proporciona una herramienta de montaje para fondo de pozo. La herramienta comprende una cubierta de herramienta y un mandril hueco, cuyo mandril está situado en la cubierta. La herramienta comprende, además, un pistón ubicado entre el mandril y la cubierta de herramienta y un manguito dispuesto entre el mandril y la cubierta de herramienta, donde la cubierta de herramienta, el mandril, el pistón y el manguito definen un espacio anular. La herramienta también comprende una primera válvula, caracterizada por que en posición cerrada la primera válvula bloquea un trayecto de comunicación fluida entre el interior del mandril y el espacio anular.
Patent EC-SP13012978-A (EC)
Title: Inhibidores de glucosilceramida sintasa
Inventor: MARSHALL JOHN
IPC: A61K31/35
Filed: 2013-10-17
Abstract: La invención está relacionada con inhibidores de glucosilceramidasintasa (GCS) útiles para el tratamiento de enfermedades metabólicas, tales como enfermedades de almacenamiento lisosómico, solos o en combinación con terapia de remplazo enzimático, y para el tratamiento de cáncer.
Patent GB-189609947-A (GB)
Title: Improvements in and connected with Covers and Ferrules of Tobacco Pipes.
Inventor: PERCY ARCHIBALD ALLAN
Filed: 1896-05-11
Granted: 1897-05-01
Abstract: 9947. Percy, A. A. May 11. Drawings to Specification. Match-striking surfaces of various forms are provided upon the hinged covers of tobacco pipes. The striking-devices may be stamped out of, or attached to, the metal of the covers. Tobacco-pipe ferrules are fitted with striking-plates provided with ribs or teeth.
Patent GB-189701521-A (GB)
Title: Improvements in Adjustable Liquid Resistances for Starting and Regulating Electric Motors.
Inventor: HOLMES JOHN HENRY
Filed: 1897-01-20
Granted: 1897-11-13
Abstract: 1521. Holmes, J. H. Jan. 20. Rheostats.-A variable liquid resistance consists of a semicircular or other tank 4, containing salt or other solution, into which a flat plate or plates 1 can be lowered by turning the shaft 2 carrying them through a semicircle by hand. The tank and plates may be ribbed circularly. The plates are balanced by a weighted arm at the rear end of the shaft. The shaft bearings are insulated, and connection made through them. In the form shown, the shaft 2 is geared by a pinion or otherwise to the handle 11 of a reversing-switch 12. The upper contacts of this consist of two blocks 13, 14 connected to the bearing of the shaft 2, and a central block 15 connected directly to the tank, to short-circuit the resistance when the plate 1 has been wholly immersed. The reversing-switch, shaft bearing, and three terminals are carried by a slate slab 8, bolted to the tank at its corners. The apparatus is specially for controlling electric motors.
Patent GB-189704570-A (GB)
Title: Improvements in Driving, Retarding, and Stopping Velocipedes and other Road Vehicles.
Inventor: GOURNY-WYSOCKI VENCESLAS
Filed: 1897-02-19
Granted: 1897-05-15
Abstract: 4570. Gourny-Wysocki, V. Feb. 19. Sociables; driving - mechanism; body motion, propelling by; brakes. - A sociable tricycle is made with a pair of driving-wheels C, C' and a front steering - wheel D. The seats s are mounted on a rocking lever l, l<1> connected by rods d, d' with cranks w, w<1> on the driving- axle a, a<1>. The seats are pivoted, so that their inclination is not altered by the rocking of the levers l, l<1>. For hill-climbing, additional power may be applied by means of levers and pawls engaging with ratchet-wheels m, m' on the driving- axle, and worked by the hand or foot, in the latter case being provided with return springs. A brake to be applied by the foot is constructed of a flexible steel band surrounding a collar f on the driving-axle and fixed at one end z<1> to the frame. The free end z<2> is provided with means for applying the foot and tightening the band, which is released again by a spring z<3>. The invention may be applied to cycles for a single rider, to quadricycles, and to multicycles.
Patent GB-189709291-A (GB)
Title: Ornaments for Hats and Dresses.
Inventor: KIRSCHNER SIEGMUND
Filed: 1897-04-12
Granted: 1897-05-22
Abstract: 9291. Kirschner, S. April 12. Drawings to Specification. Ornamenting; flowers, artificial.-Ornaments in the form of tassels or pompons, fringes, or flowers for hats &c. are made by stringing together narrow slips of gelatine on threads or wire.
Patent GB-189711854-A (GB)
Title: Improvements in Apparatus for Swaging Dental Plates.
Inventor: GARTRELL JOHN HUTCHENS
Filed: 1897-05-12
Granted: 1898-04-23
Abstract: 11,854. Gartrell, J. H. May 12. Stamping and embossing.-Dental and other plates are swaged or pressed into shape in an apparatus of the form shown. This consists of a cylinder a, closed at one end and fitted with a plunger b, which can be forced downwards by placing it in a screw press p and rotating the screw s. The tray containing the model, on which is laid the metal or other plate, is first placed in the bottom of the cylinder and held in position by a plug a<2> fitting a recess a<1>; the cylinder is then filled up with small shot or steel balls, the plunger b inserted, and the press operated. A disc of rubber may be inserted between the plate and the shot. In a modification, the cross-bar of the press is pivoted to the cylinder and the latter provided on the bottom with a rib for holding it in a groove or vice. When treating a badly-fitting vulcanite plate, the whole apparatus is immersed in boiling water so as to soften the vulcanite.
Patent GB-189716620-A (GB)
Title: Improvements in Velocipedes.
Inventor: HICKS BOHN CHAPIN
Filed: 1897-07-13
Granted: 1897-09-18
Abstract: 16,620. Hicks, B. C., and Drake, J. A. July 13. Frames ; single-track tricycles. - To the main frame A of a velocipede an auxiliary frame D is jointed at a point adjacent to the axle d of the rear wheel. This auxiliary frame is provided with a pivoted portion D' carrying a trailing wheel E and a connecting-bar G forked at G', pivoted to the main frame at g, and to the auxiliary frame by means of two vertical links g<1>. Stops g', g<4> are provided to limit the movement of the links g<1>. The saddle G<1> is secured to the bar. G in any desired manner.
Patent GB-189718349-A (GB)
Title: Improvements in Liquid Sealed Valves for Air and Gases.
Inventor: HANNAN JOHN ROBERT
Filed: 1897-08-06
Granted: 1898-06-04
Abstract: 18,349. Hannan, J. R., Hart, J., and Hart, J. A. Aug. 6. Valves for reversing the current of gas through regenerative furnaces. Two hinged valves c and d of the form shown are provided, having flanges all round and on both sides of their edges, and horizontal slots in their back edges in which horiz o n t a l spindles d<1> are secured by cottars or bolts. Water or other liquid is admitted by pipes b and fills the upper sides of the valves, thence overflowing to the seats, and finally passing away by overflow spouts n. This liquid serves to seal the valves and to protect them and their seats from the effects of heat. When the valves are in the positions shown, gas from the gas-producer enters the casing A by way of the inlet a, and thence passes through the passage f to the furnace, while the waste gases from the furnace pass by way of the passage e to the casing B, and thence through the opening l to the chimney flue m. To reverse the current, the valves c and d are turned through 180‹, to bear on their opposite seats, by means of the gearing g. Counterbalance weights j are provided.
Patent GB-189722855-A (GB)
Title: Improvements in Workmen's Time Checking Apparatus.
Inventor: BUERK RICHARD
Filed: 1897-10-05
Granted: 1898-01-29
Abstract: 22,855. B³rk, R. Oct. 5. Date and time printing stamps.-The time of entering and leaving works &c. is printed on a small card. The spur-wheel B, driven by a suitable clock, has keyed to its spindle a disc b<1>, to which is eccentrically pivoted a slotted spring- pressed arm b<2>, which by the rotation of the disc b<1> is pulled in a series of jerks over the rollers H. This step-by-step motion is communicated by the pin g to the wheels E, D, C, which carry suitable numbers for printing the time. The stamp may be pressed down by a knob, or else may be fixed, while the rest of the apparatus is oscillated under it, so that the arm k<1> may squeeze the card on to the type wheels. A projection k<3> cuts off a piece from the side of the card on the sharp edge M, so that at the next insertion of the card it may be pushed in further. To prevent fraud, the check device q, which prints in line with the type-wheels, is changed at arbitrary times. Several sets of type-wheels may be carried on the shaft F, to the back end of which may then be connected a stronger clockwork to assist the first as soon as the arm b<2> is drawn clear of one of the rollers H.
Patent GB-189722856-A (GB)
Title: Improvements in Weaving Looms for Changing the Shuttles on Breakage or Failure of Weft.
Inventor: ROSS HUGH ROBERT
Filed: 1897-10-05
Granted: 1898-08-20
Abstract: 22,856. Ross, H. R. Oct 5. Loom shuttle-changing mechanism.-The shuttles are stored in a fixed cage or receptacle H, and are transferred singly from it to a rotary shuttle box K, having a number of chambers k with holding-springs and with cam-actuated slides for ejecting the empty shuttles. When the weft fails, the weft fork D engages the oscillating hammer lever E and transmits motion to the pivoted lever T<1>, connectind-rod t, and cranked lever T, thereby putting the hooked lever P<1> into engagement with the oscillating lever o. This causes the lever 0 to be oscillated, and by means of the hooked lever P rotates the shuttle box. The same motion, by means of an arm W, camactuated link w<1>, and lever W', brings the bowl s<1> on the disc s<11> into engagement with the lever V<1>, which, by means of a bell-crank lever V and springs v, v<1>, causes the pusher h to transfer the lowest shuttle in the cage H to the shuttle box after a partial revolution of the shuttle box has taken place.
Patent GB-189725418-A (GB)
Title: Apparatus for Roasting Coffee.
Inventor: OKELL JOHN R
Filed: 1897-11-02
Granted: 1898-01-29
Abstract: 25,418. Okell, J. R., and Petersen, O. J. Nov. 2 Roasting coffee.-Relates to the construction of apparatus for roasting coffee by subjecting it to the action of the fumes from a furnace. The apparatus comprises a rotary drum C suitably mounted within a casing B provided with a flue for the discharge of the furnace gases and with a hopper-shaped discharge orifice b<1>, in which a tray b<6> filled with water can be inserted to catch the hulls that fall from the drum C during the roasting operation. The drum C is provided with a mouth c<4> connected by a shoot e with a furnace E having a large combustion chamber so that all the fuel is completely consumed. The shoot e is formed with a hopper e<1> to collect any coffee that may be thrown out of the drum C. The drum C is formed with a number of orifices c<6> in its periphery closed by sliding doors operated by links g<1> from a series of pivoted levers G connected to a ring g<2> which can be screwed on the threaded sleeve g<6> to open the said sliding doors for the discharge of the coffee from the drum C. Lifting-appliances are arranged inside the drum C, and consist of a series of parallel lifting- blades H, a series of helical blades h secured to the inner edges of the blades H, and a second series of helical blades h<1> secured to the inner edges of the blades h and inclined in the opposite direction to the said blades. The coffee is introduced into the drum C from a hopper F with valve f<1>. The Specification describes two other modifications of the apparatus for opening the discharge orifices in the periphery of the drum C.
Patent GB-189726082-A (GB)
Title: Improvements in the Construction of Rail Joints and in Methods of Forming the same.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-11-09
Granted: 1897-12-11
Abstract: 26,082. Thompson, W. P., [Austin, W. J.]. Nov. 9. Rail joints; rail bonds.-The perforated ends of the rails are placed in a sleeve, which is then filled with molten metal. The sleeve is in one piece, or in two parts secured together and adapted to hold the ends of the rails in position. The molten metal fuses on to the rail ends and acts as a bond.
Patent GB-189805077-A (GB)
Title: Improvements in the Manufacture of Railway and like Buffer Casings.
Inventor: TIMAR DAGOBERT
Filed: 1898-03-01
Granted: 1898-08-06
Abstract: 5077. Timar, D. March 1. Making railway and like buffer casings.-A solid bar of steel or iron has a flange jumped on its end and is then bored out as shown at c, Fig. 1, by suitable tools, such as those marked a and b. Longitudinal slots d, Fig. 2, are then cut in the sides, and the casing is placed in the die e, Fig. 4, which consists of three blocks pressed together by springs g. After the casing c has been placed in the die e a mandrel is forced in, so as to expand the flanged end of the buffer casing into the form shown in end view in Fig. 3, and in dotted lines in the lower part of Fig. 2.
Patent GB-189805111-A (GB)
Title: Improvements in and relating to Handles for Coal Boxes and the like.
Inventor: ALEXANDER HUGH
Filed: 1898-03-02
Granted: 1899-01-07
Abstract: 5111. Alexander, H. March 2. Handles.-The handle A of a coal box &c. is of turned wood or brass, and has longitudinal holes a at the ends into which are inserted nuts c. Screwed rods d are passed through transverse holes and engaged with the nuts. Knobs A<1> are glued in the ends of the holes a. Standards B of wood or brass are threaded on the rods, which are then passed through holes in the top of the coal box &c. and are secured by nuts d<3>.
Patent GB-189806499-A (GB)
Title: Improvements in the Manufacture of Woven Figured Plushette and similar Fabrics.
Inventor: DENTON WILLIAM HIRAM
Filed: 1898-03-17
Granted: 1898-04-23
Abstract: 6499. Denton, W. H. March 17. Plushette &c.-Woven figured plushettes and similar fabrics are made with one warp and one weft instead of two warps and two or more wefts. The Figure shows a fabric woven five picks to the round, in which a is the cotton or other warp and b the cow-hair or similar weft. The woven fabric is raised to produce the nap or pile, and finished in the ordinary way.
Patent GB-189807768-A (GB)
Title: An Improved Motor for Sewing Machines.
Inventor: VALETTE ANGEL
Filed: 1898-03-31
Granted: 1899-03-18
Abstract: 7768. Valette, A. March 31. Spring motors for sewing-machines. Fig. 2 shows the four springs A arranged round a horizontal axle B, to which they are fastened by screws. The winding up of the springs is done by means of a crank handle and gear put in or out of operation by means of a lever F. Motion is transmitted from the axle B to the flywheel by means of wheel and chain gearing. The speed of the machine is controlled by a hand-lever actuating a friction brake operating on the driving-wheel.
Patent GB-189812612-A (GB)
Title: An Improved Process for Obtaining Sterilized Raw Meat in the Condition of Powder.
Inventor: GROGNET FELIX
Filed: 1898-06-04
Granted: 1898-10-01
Abstract: 12,612. Grognet, F. June 4. Food preparations; preserving meat.-To obtain sterilized raw meat in the condition of powder, the fresh meat is grated and placed on a sleve with a suitable quantity of lentil or other flour. After removing the excess of flour the meat is sterilized by dipping it into a bath, which may be composed of wine vinegar, common salt, crushed ginger, spices, pepper, and acetate of potash in specified proportions. Aromatic plants may be introduced. The product is dried and then pulverized. Meat in the piece or quarter may be preserved in a similar manner.
Patent GB-189816396-A (GB)
Title: Improvements in and appertaining to the Working of Incandescence Electric Lamps.
Inventor: MACLAGAN DONALD
Filed: 1898-07-27
Granted: 1899-06-17
Abstract: 16,396. MacLagan, D. July 27. Switches for incandescent lamps having filaments which conduct only after preliminary heating by adjacent wire coils or the like, for disconnecting the heating-circuits when the filaments have become conductive. In one arrangement, several filaments F, F<1>, F" are connected in parallel, and are all heated by one coil H, the circuit of which is closed by a switch until one of the filaments becomes conductive. In the arrangement shown, current is supplied to the coil H through a spring s and a screw m. Simultaneously current passes from the screw m through a spring s', a lever L, and an electromagnet M, which attracts an armature lever A. This shifts the lever L, breaking its contact with the spring s', and causing the pawl R to turn a ratchet-wheel W and a fourarmed switch C'. The switch C<1> connects any one of the filaments in circuit, through an electromagnet M', and a reverse winding on the magnet M. The armature lever A then moves to the right, opening the heating-circuit by moving the spring s. In a modification, a single filament only is provided, the ratchet switch C' and pawl lever L being dispensed with. The armature lever A is adapted to close the heating and filament circuits through the magnets M, M', and afterwards open the heating-circuit and connect a resistance in parallel with the magnet M<1>, in series with the filament. In a further modification, the magnet M is dispensed with. Solenoids and movable cores may be substituted for electromagnets and armatures, in either arrangement.
Patent GB-189819585-A (GB)
Title: An Improved Gully Trap.
Inventor: WHITE ROBERT
Filed: 1898-09-15
Granted: 1899-09-09
Abstract: 19,585. White, R. Sept. 15. Gully traps.- The trap is formed by a sliding dip - plate A. A pivoted disc B in the outlet prevents back flow of water or gas.
Patent GB-189820914-A (GB)
Title: Improvements in Axle Boxes and Axle Bearings for the Wheels of Carriages and other Vehicles.
Inventor: BRESLAUER EDUARD
Filed: 1898-10-04
Granted: 1898-11-26
Abstract: 20,914. Breslauer, E. Oct. 4. Axle boxes and other axle bearings; wheels.-Figs. 1 and 2 show sections through the hub, axle arm, and bearing of a wheel for street-railway and other vehicles, the method of detaching the wheel being indicated in Fig. 2. The hub supports the axle arm A on the roller bearings r and ring R, and the axle arm has a groove into which balls B are pressed by nuts M', M<2>. The wheel may be detached by first slightly unscrewing the nut M<2>, which allows the balls to fall free of the groove. During detachment of the wheel the balls are prevented from falling out of position by the spring-controlled ring C. In a modification, the balls are secured by a single nut, which is prevented from rotating out of position by set-screws.
Patent GB-189902199-A (GB)
Title: Improvements in Machines for Cleaning or Scutching Hemp and other Fibres.
Inventor: TORROELLA JOSE
Filed: 1899-01-31
Granted: 1899-03-18
Abstract: 2199. Torroella, J. Jan. 31. Breaking and scutching apparatus for hemp &c. The material is held between a pair of grooved discs b, b<1> inclined to one another, the lower disc being horizontal and having a vertical axle 14, while the upper one is held in the inclined position shown by the bracket 17, its axle 15 being connected with the axle 14 by means of a universal joint 16. The material is supplied from a feedtable into the space between one pair of discs, which grip the material by nne end and pass the free end into the mouth 33 of a casing 31 containing a scraping or scutching drum C, the knives 35 on which are bevelled as shown. The continuous rotation of the discs withdraws the scutched ends from the drum C, and by means of a suitable guide they are passed between a second pair of similar discs, while the ends which were formerly held are simultaneously released. The unscutched ends are then carried by the second pair of discs within the range of a second scutching-drum similar to C, when the scutching operation is completed.
Patent GB-189902573-A (GB)
Title: Improvements in or relating to Pneumatic Tyres.
Inventor: BOULT ALFRED JULIUS
Filed: 1899-02-04
Granted: 1899-12-16
Abstract: 2573. Hoult, A. J., [Drouet, A.]. Feb. 4. Tyres, pneumatic. - The air tube c, shown inflated in Fig. 2, is surrounded by an outer cover b the edges of which are connected together by threads, cords, or the like f, g, h, i arranged in sets, so that the tbreads of one set are inclined to the edges of the cover and to the threads of the next set. Inflation of the air tube attaches the tyre to the rim a, and the deflated air tube can easily be pulled out between the threads for the purpose of repair.
Patent GB-189911892-A (GB)
Title: A New or Improved Grip for Holding Ropes, Rods, and for similar purposes.
Inventor: SWINBURN WILLIAM
Filed: 1899-06-07
Granted: 1900-05-12
Abstract: 11,892. Swinburn, W. June 7. Rope grips.-Relates to a grip for wire and other ropes, rods, and the like, applicable for towing, trawling, and lifting purposes generally. The rope b is gripped between the wedge h and the frame or bracket a. An opening on one side of the frame allows the insertion of the wedge and rope, and is closed by a pivoted latch c with an inner projecting part i. The roller f for the wedge to bear against may be mounted on the pin d, and an eye k is provided on the wedge.
Patent GB-189912588-A (GB)
Title: Improved Means for Securing Cycle Pedal Pins in Cycle Cranks.
Filed: 1899-06-16
Granted: 1900-04-21
Abstract: 12,588. Sherborne Components and Cycle Manufacturing Co. and Hurley, W. June 16. Cranks; pedals.-Relates to means for connecting the pedal pin to the crank. The inner end a<2> of the pedal pin A is formed with a groove to receive a divided ring C<1>, C<2>, and is threaded to receive a nut D. The crank B is bored out large enough to allow the passage of the end a<2> of the pin, and is formed with a recess to receive the ring C', C'. A stud E on the pin A engages a groove in the crank to prevent rotation. The parts are assembled by pushing the end a<2> far enough through the crank to allow the divided ring to be placed in the groove ; the nut D is then screwed up so as to draw the ring into the recess, thus locking the parts together.