baber/WOPTO huggingface dataset:
Patent CY-1108002-T1 (CY)
Title: Παραγωγα 4-ετεροκυκλυλοσουλφοναμιδυλο-6-μεθοξυ-5- (2-μεθοξυ-φαινοξυ)-2-πυριδυλο-πυριμιδινης, παρασκευη αυτων, και χρηση τους ως ανταγωνιστες υποδοχεα ενδοθηλινης
Inventor: BREU VOLKER
IPC: C07D417/14
Filed: 2007-03-08
Abstract: Οι ενώσεις του τύπου (I), όπου R1 είναι ετεροκυκλικό υπόλειμμα εκλεγόμενο από πυριδύλιο και θειαζολύλιο, και όπου το εν λόγω ετεροκυκλικό υπόλειμμα μπορεί να είναι προαιρετικώς υποκατεστημένο με κατώτερο αλκύλιο ή κατώτερο αλκενύλιο· και φαρμακευτικώς παραδεκτά άλατα αυτών, είναι αναστολείς υποδοχέων ενδοθηλίνης και μπορούν, έτσι, να χρησιμοποιηθούν για τη θεραπεία διαταραχών οι οποίες συνδέονται με μη-φυσιολογικό αγγειακό τόνο και ενδοθηλιακή δυσλειτουργία· και τα αντίστοιχα ενδιάμεσα των τύπων (III) και (V).
Patent CY-1108282-T1 (CY)
Inventor: GUZMAN CARLOS ALBERTO
IPC: A61K39/39
Filed: 2008-08-22
Abstract: The use of lipopeptides or lipoproteins (I), designated macrophage activating lipopeptides (MALP), as a mucosal adjuvant for therapeutic or prophylactic vaccination viathe mucosa is new. Also claimed is the use of (I) (with some specific compounds excepted) as adjuvants for non-mucosal vaccination. The use of a lipopeptide or lipoprotein of formula (I) is claimed as a mucosal adjuvant for therapeutic or prophylactic vaccination viathe mucosa. [Image] R 1, R 27-25C alkyl, 7-25C alkenyl or 7-25C alkynyl; X : S, O or CH 2; R 3, R 4H or Me; and Y : sequence of 1-25 (preferably 12-25) amino acid residues, which is physiologically acceptable and not in itself immunogenic in the species to be treated; provided that the asterisked C atom has absolute R-configuration if X = S. An independent claim is also included for the use of (I) as adjuvant for non-mucosal vaccination, with the additional proviso that (I) is other than an S-(2,3-diacyloxypropyl)-cysteine peptide (I') of the sequence Asp-hcGly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Glu-Ser-Phe-Glu-Lys-Glu-Lys, where the amino acids in position 2 and optionally 3 at the N-terminal are optionally absent and/or 1 or 2 aminoacids may be deleted from the C-terminal. ACTIVITY : Immunostimulant. Mice were immunized intranasally on days 0, 7 and 14 with 40 mu g beta -galactosidase (as model antigen) or a mixture of 40 Microg beta -galactosidase and 1 Microg MALP-2 (Ia) as adjuvant. On day 28 serum samples were analyzed by enzyme-labeled immunosorbent assay for the beta -galactosidase-specific antibody titer. The titers, in absorption value units (OD 405 nm), were 0.25 in the absence of (Ia) and 0.30 in presence of (Ia). MECHANISM OF ACTION : None given.
Patent CY-1112164-T1 (CY)
Inventor: ZHOU XIAO-XIONG
IPC: C07D493/04
Filed: 2011-12-22
Abstract: A compound of the formula:   
for use in the treatment of retroviruses such as HIV, especially drug escape mutations.
Patent CY-1113530-T1 (CY)
Inventor: MENGELING WILLIAM L
IPC: A61P31/20
Filed: 2012-06-29
Abstract: Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation.
Patent CY-1114224-T1 (CY)
Title: Συζευγματα εστερα αλφα αμινοξεως-φαρμακου υδρολυομενα απο καρβοξυλεστεραση
Inventor: DAVIDSON ALAN HORNSBY
Filed: 2013-07-23
Abstract: Η ομοιοπολική σύζευξη ενός εστέρα άλφα αμινοξέως με έναν ρυθμιστή της δράσης του ενδοκυτταρικού ενζύμου ή υποδοχέα που αποτελεί το στόχο, όπου η εστερική ομάδα του συζεύγματος δύναται να υδρολυθεί με ένα ή περισσότερα ενδοκυτταρικά ένζυμα καρβοξυλεσταράσης στο αντίστοιχο οξύ, οδηγεί στη συσσώρευση του προϊόντος της υδρόλυσης του καρβοξυλικού οξέως στο κύτταρο και επιτρέπει τη βελτιωμένη και παρατεταμένη ρύθμιση του ενζύμου ή του υποδοχέα σε σύγκριση με τον μη συζευγμένο ρυθμιστή.
Patent CY-1114931-T1 (CY)
Title: Συσκευη οπτικης απεικονισης
Inventor: BRENNAN JOHN MICHAEL
IPC: G09F19/12
Filed: 2014-03-07
Abstract: Αποκαλύπτεται μια συσκευή οπτικής απεικόνισης (1) η οποία βρίσκει ειδική χρήση ως επιγραφή στη διαφήμιση λιανοπωλητών ή ως παιχνίδι στο οποίο ένα παιδί μπορεί να διευθετήσει στοιχεία απεικόνισης (5) σε ένα ελκυστικό μοτίβο. Η επιγραφή (1) περιλαμβάνει ένα σιδηρομαγνητικό υποστήριγμα (2) επάνω στο οποίο μπορούν να τοποθετηθούν μαγνητικά στοιχεία απεικόνισης (5). Κάθε στοιχείο (5) απαρτίζεται από μια μαγνητική βάση (10), έναν άξονα (11) ο οποίος προεξέχει από τη μαγνητική βάση (10) μέσα από την οπή (30) ενός περιφερειακώς οδοντωτού γραναζιού που μοιάζει με δίσκο (13) και μέσα από την οπή (31) ενός αποστάτη (19), με τον αποστάτη (19) να είναι επικολλημένος στο οδοντωτό γρανάζι (13), και ένα έλασμα απεικόνισης σε σχήμα δίσκου (15) τοποθετημένο επάνω στον αποστάτη (19) και στερεωμένο σε αυτόν. Τα οδοντωτά γρανάζια (13) γειτονικών στοιχείων (5) συνδέονται έτσι ώστε η περιστροφική κίνηση ενός στοιχείου (5) να προκαλεί κίνηση του γειτονικού στοιχείου (5). Τα γειτονικά στοιχεία (5) είναι τοποθετημένα επάνω στην επιφάνεια στήριξης για να διευκρινίσουν μια λέξη ή άλλη απαιτούμενη διαφήσιμη. Ένας ηλεκτρικός κινητήρας είναι η προτιμώμενη πηγή ισχύος για την περιστροφή του στοιχείου απεικόνισης (5) αν και η χειροκίνητη λειτουργία είναι δυνατή.
Patent CY-1117725-T1 (CY)
Title: Νανοσωματιδια πακλιταξελης και λευκωματινης σε συνδυασμο με μπεβασιζουμαμπη εναντι καρκινου
Inventor: DESAI NEIL P
IPC: A61K45/06
Filed: 2016-06-17
Abstract: Η παρούσα εφεύρεση παρέχει μεθόδους θεραπείας συνδυασμού αγωγής υπερπλαστικών παθήσεων (όπως είναι ο καρκίνος) περιλαμβάνοντας μια πρώτη θεραπεία περιλαμβάνοντας την χορήγηση σε ένα άτομο μιας αποτελεσματικής ποσότητας μιας ταξάνης σε μια σύνθεση νανοσωματιδίων, και μία δεύτερη θεραπεία η οποία μπορεί να συμπεριλάβει, για παράδειγμα, ακτινοβολία, χειρουργική, χορήγηση χημειοθεραπευτικών παραγόντων (όπως είναι ένα αντίσωμα αντι-VEGF), ή συνδυασμούς εξ' αυτών. Επίσης παρέχονται μέθοδοι χορήγησης σε ένα άτομο ενός φαρμάκου ταξάνης σε μία σύνθεση νανοσωματιδίων βάσει ενός σχήματος χορήγησης μετρονομικής δοσολόγησης.
Patent CY-1118286-T1 (CY)
Title: Μεθοδος και τεχνικο μεσο για τη θεραπευτικη αγωγη φλεγμονωδους νοσου εντερου
Inventor: THÖRN MAGNUS
IPC: C07K16/28
Filed: 2016-11-15
Abstract: Μέθοδος για τη θεραπευτική αγωγή φλεγμονώδους νόσου εντέρου (IBD) περιλαμβάνει παροχή εντερικού δείγματος βιοψίας, λαμβανόμενου από φλεγμαίνοντα ιστό ενός ασθενούς• κατεργασία με μηχανικό τρόπο του δείγματος για τη λήψη εναιωρήματος κυττάρων• ταυτοποίηση δεικτών κυτταρικής επιφάνειας των ενεργοποιημένων λευκοκυττάρων, επιλεγόμενων από Τ λεμφοκύτταρα, ουδετερόφιλα κοκκιοκύτταρα, και ηωσινόφιλα κοκκιοκύτταρα στο εναιώρημα• ανάπτυξη αντισωμάτων έναντι ενός ή περισσοτέρων εκ των ενεργοποιημένων κυττάρων και ακινητοποίηση αυτών πάνω σε υλικό στήριξης• παροχή στήλης φορτωμένης με το υλικό στήριξης• εκτροπή μεριδίου του περιφερικού αίματος του ασθενούς ώστε να περάσει μέσα από τη στήλη και προτού επανεγχυθεί στον ασθενή ώστε τα ενεργοποιημένα λευκοκύτταρα να συζευχθούν με αντισώματα πάνω στο υλικό στήριξης, εξαλείφοντας έτσι τα από το ρεύμα αίματος. Επίσης αποκαλύπτονται αντίστοιχες στήλες και υλικά στήριξης, και η χρήση τους στη μέθοδο.
Patent CY-1118571-T1 (CY)
Title: Συσκευη προσδεσης για την προσδεση ενος σκαφους
Inventor: BOERLEIDER JOHAN MARLON
IPC: B63B21/02
Filed: 2017-01-31
Abstract: Συσκευή πρόσδεσης για την πρόσδεση ενός σκάφους και που περιλαμβάνει μια βάση, μια δομή μετακινούμενου βραχίονα που υποστηρίζεται από τη βάση, και τουλάχιστον έναν μαγνήτη τοποθετημένο μέσα σε ένα πλαίσιο, το οποίο πλαίσιο στηρίζεται από τη δομή ενός μετακινούμενου βραχίονα, και όπου για την πρόσδεση του σκάφους ο τουλάχιστον ένας μαγνήτης έχει ρυθμιστεί έτσι ώστε να έλκει το κύτος του σκάφους, όπου στο ή κοντά στον τουλάχιστον έναν μαγνήτη παρέχεται μια συσκευή που δημιουργεί μια δύναμη η οποία συσκευή περιλαμβάνει ένα μετακινούμενο τμήμα που ασκεί τη δύναμη για την εφαρμογή μιας δύναμης πάνω στο κύτος του πλοίου προκειμένου να ελεγχθεί εάν ο μαγνήτης που έλκει το κύτος του σκάφους παρέχει τουλάχιστον μια απαιτούμενη δύναμη πρόσδεσης, και παρέχονται αυτά τα μέσα υπολογισμού για τον υπολογισμό της απόστασης ανάμεσα στον τουλάχιστον ένα μαγνήτη και το κύτος του σκάφους, τα οποία είναι συνδεδεμένα ή μπορούν να συνδεθούν σε μια συσκευή ανίχνευσης για την ανίχνευση εάν ή όχι ο μαγνήτης είναι χαλαρός από το κύτος του πλοίου.
Patent CY-1119419-T1 (CY)
Title: C1-inh συνθεσεις για χρηση στην προληψη και αγωγη κληρονομικου αγγειοοιδηματος (ηαε)
Inventor: GALLAGHER CYNTHIA
IPC: A61P31/00
Filed: 2017-09-12
Abstract: Αποκαλύπτονται συνθέσεις και μέθοδοι για την αγωγή και/ή πρόληψη διαταραχών συνδεόμενων με ανεπάρκεια αναστολέα C1 εστεράσης.
Patent GR-910300108-T1 (GR)
Title: Tubular protective device for protection against transfer of infectious matter during sexual intercourse
Inventor: HESSEL LASSE
IPC: A23L/
Filed: 1991-12-10
Abstract: A thin-walled, condom-like tubular protective device (1) for protection against the transfer of infectious matter during sexual intercourse is disclosed. The condom-like device has at its open end a collar-shaped outwardly extending portion (3) with means (4) for radially stretching the collar and has an inner diameter which is sufficiently large to permit movement of a penis with respect to the protective device during coitus.
Patent GR-970300038-T1 (GR)
Title: Filtration
Inventor: WINGE STEFAN
IPC: C07K14/47
Filed: 1997-11-28
Abstract: Filtration methods comprise virus-filtering a solution containing a least one macromolecule. The total salt content of the solution for virus-filtering is within the range of from about 0.2 M up to saturation with the salt. Salts that can be used in the filtering methods include sodium chloride, potassium chloride, sodium acetate, sodium citrate, sodium phosphate, potassium dyhydrophosphate and combinations thereof.
Patent SI-1533262-T1 (SI)
Title: Method for winding a material web
Inventor: MCGREAL MICHAEL
IPC: B65H19/28
Filed: 2003-11-19
Abstract: The method for winding rolls of paper, plastic film or metal foil on hollow cardboard cores (12) comprises applying a patch (18) of aqueous gel-forming material to the end (11) of the sheet (10) of material. This end is then applied to the surface (14) of the core.
Patent SI-1696056-T1 (SI)
Title: High strength polyethylene fiber
Inventor: SAKAMOTO GODO
IPC: D01F6/04
Filed: 2004-12-03
Abstract: PURPOSE: To provide a novel high strength polyethylene multifilament which consists of a plurality of filaments having high strengths and uniform internal structures, and showing a narrow variation in the strengths of the monofilaments, and which has been difficult to be provided by the conventional gel spinning method.  SOLUTION: A high strength polyethylene multifilament consisting of a. plurality of filaments which are  characterized in that  the stress Raman shift factor is - 5.0 cm -1  / (cN/dTex) or more; the crystal size of monoclinic crystal is 9 nm or less, the average strength is 20 CN/dTex or higher; the knot strength retention of each monofiiament is 40% or higher; CV indicating a variation in the strengths of the monofilaments is 25% or lower; the elongation at break is from 2.5% inclusive to 6.0% inclusive; the fineness of each filament is 10 dTex or less; and the melting point of the filaments is 145°C or higher.
Patent SI-1963260-T1 (SI)
Title: Process for the production of ezetimibe and intermediates used in this process
Inventor: BODI JOZSEF
IPC: C07D205/00
Filed: 2006-12-18
Abstract: A process for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the following reaction scheme: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) where the substances of the general Formulas II, IV, VI, VIII, IX, X and XI are new, Formula III is a non-isolated intermediate, R1, R2 and R3 are represented by the compounds of Formulas Va-Vd, (Va), (Vb), (Vc), (Vd) and R4 is a silyl, e.g., tert-butyl-dimethyl-silyl, tert-butyl-diphenyl-silyl group.
Patent SI-2115671-T1 (SI)
Title: System and method for digital multi-lateral proofreading during a meeting
Inventor: SITBON DAVID EDUARD
IPC: G06F3/14
Filed: 2007-12-31
Abstract: A digital multi-lateral system and method for proofreading a composition during a meeting. The system comprises a multi-screened monitor unit having a first screen and at least one oppositely facing second screen mounted in a common housing, images of a selected composition being viewable simultaneously on the first screen and the at least one second screen, a computer coupled to the monitor unit and provided with a dedicated software module for interfacing with the monitor unit, one or more primary and secondary co-author input devices, and means for transmitting signals generated by each co-author input device to the computer. Correction data is transmitted by a co-author input device to the computer, which transmits corrected image data simultaneously to the first and second screens. In one embodiment, the monitor unit receives VGA data and USB video data from the computer and transmits the same to the first and second screens, respectively.
Patent SI-2265580-T1 (SI)
Title: Novel method for the production of sulphonylpyrroles as hdac inhibitors
Inventor: MULLER MATTHIAS
IPC: A61K31/40
Filed: 2009-03-11
Abstract: Process for the preparation of a compound of formula I:   
wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, 
comprising the step of reacting an acrylic acid chloride compound of formula II':   
wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, with aqueous hydroxylamine 
and optionally converting the resulting compound into an acid addition salt thereof.
Patent SI-2774120-T1 (SI)
Title: Method of deriving intra predicion mode
Inventor: OH SOO MI
IPC: H04N19/593
Filed: 2012-11-02
Abstract: Provided is a method that constructs an MPM group including three intra prediction modes, determines the intra prediction mode of the MPM group specified by the prediction mode index as the intra prediction mode of the current prediction unit if the mode group indicator indicates the MPM group, and derives the intra prediction mode of the current prediction unit using the prediction mode index and the three prediction modes of the MPM group is the mode group indicator does not indicate the MPM group. Accordingly, additional bits resulted from increase of a number of intra prediction mode are effectively reduced. Also, an image compression ratio can be improved by generating a prediction block similar to an original block.
Patent SI-3033295-T1 (SI)
Title: Device and method for transporting heavy duty racks by means of a transport vehicle on an uneven ground surface
Inventor: MECKLINGER SIEGFRIED
IPC: B66F9/00
Filed: 2014-08-11
Abstract: The invention relates to a device and to a method for transporting heavy duty racks on an uneven ground surface by means of a transport vehicle, comprising the following features: a) a housing (3) having a carrier plate (1) for transporting a heavy duty rack (12), having two separately powered drive wheels (20) hinged to a respective axis of rotation (5) on both sides in the center of the housing (3), having at least one stabilizing wheel (9) in the front and at least one stabilizing wheel (21) in the back; b) a transverse control arm (34), which connects the drive wheels (20), which respectively can be pivoted about the axis of rotation (5) by means of an angle lever (40) such that they are able to carry out vertical movements independently from one another; c) a centrally arranged actuating element (31), which can move two front lift rods (19) and two rear lift rods (16) by means of a lifting rotary lever (27) and of a push rod (24) connected thereto, for raising and lowering the carrier plate (1); d) a system for supplying a transport vehicle with energy.
Patent TR-200606459-T1 (TR)
Title: Suyun taşması önlenen bir yıkama makinası
Inventor: CENGIZ ENDER
IPC: A47L15/42
Filed: 2005-05-25
Abstract: Bu buluş, bir haznede biriken su ile yükselen bir şamandıranın (6), bir taşma önleyici mekanizmayı (5) harekete geçirerek, su dolaşım sistemindeki kaçaklar, su giriş vanası (3) arızası veya fazla su alınması sonucu oluşan taşmaları önlenen bir yıkama makinası (1) tercihan bulaşık makinası veya çamaşır makinası ile ilgilidir. Taşma önleyici mekanizma (5), şamandıra (6) tarafından harekete geçirildiğinde tahliye anahtarı (7) ve su giriş anahtarını (8) aynı zamanda tetikleyen bir kaldıraç içermektedir.
Patent DE-3586306-T2 (DE)
Inventor: ROSENBERG PERETZ
IPC: B01D/
Filed: 1985-10-03
Granted: 1993-02-25
Abstract: A multiple-disc filter comprises a stack of filtering discs (114) each formed with grooves extending only partially through the thickness of the disc (114) and configured to define a continuous, non-apertured surface on one face and a plurality of spaced ribs (140) projecting from the opposite faces. The ribs are connected together to define a sinuous configuration and have straight line edges. The stack further includes spacing ribs (151, 152, 153) between the confronting faces of adjacent discs of the stack for spacing the straight line edges of the sinuous ribs (140) of one disc (114) from the confronting face of the next adjacent disc (114) in the stack, such that the confronting faces of adjacent discs (114) define a first group of recesses (161) between the ribs (140) communicating with a filter inlet (104), a second group of recesses (162) alternating with the first group of recesses (161) and communicating with a filter outlet (106), and a plurality of filtering passageways (163) between the straight line edges of the ribs (140) and the confronting face of the next adjacent disc (114).
Patent DE-3587656-T2 (DE)
Inventor: HULL CHARLES W
IPC: B29C35/08
Filed: 1985-08-06
Granted: 1994-04-28
Abstract: A system for generating three-dimensional objects by creating a cross-sectional pattern of the object to be formed at a selected surface of a fluid medium capable of altering its physical state in response to appropriate synergistic stimulation by impinging radiation, particle bombardment or chemical reaction, successive adjacent laminae, representing corresponding successive adjacent cross-sections of the object, being automatically formed and integrated together to provide a step-wise laminar buildup of the desired object, whereby a three-dimensional object is formed and drawn from a substantially planar surface of the fluid medium during the forming process.
Patent DE-3650600-T2 (DE)
Inventor: PARNOFF GEORGE
IPC: G01N21/35
Filed: 1986-10-10
Granted: 1997-07-03
Abstract: A gas analyzer is described comprising a sample cell for containing a gas mixture to be analyzed, a source for producing and directing infrared energy through the sample cell, a rotary filter wheel having at least one filter thereon for passing infrared energy limited to a wavelength band within the characteristic absorption band of a predetermined gas and having a dark level region substantially opaque to infrared energy, a drive for supporting and rotating the filter wheel to successively interpose the filter and the dark level region between the source and the sample cell in the path of the infrared energy directed by the source, a detector for detecting infrared energy passing through the sample cell and producing an electrical signal representative thereof, and a signal processor connected to the detector for producing an output indicating the concentration of the predetermined gas in the sample cell by comparing the electrical signals produced by the detector with the filter positioned in the infrared energy path and with the dark level region positioned in the infrared energy path. The dark level region has a substantially fully reflective surface oriented toward the sample cell when positioned in the infrared energy path whereby infrared energy impinging thereon is reflected.
Patent DE-3751344-T2 (DE)
Inventor: TYSZBLAT MICHELE
IPC: A61C13/08
Filed: 1987-04-10
Granted: 1996-03-07
Abstract: In the production of ceramic dental prostheses, a model of the tooth is made; a slurry is prepared, consisting of a suspension of metallic oxide particles in water; the model of the tooth is brought into contact with the slurry; the layer of metallic oxides is given the external shape which it is desired to confer upon the infrastructure of the prosthesis; the model of the tooth thus covered with metallic oxides is baked in order to effect a slight solid-phase sintering of the metallic oxide particles; and a glass is used to impregnate the infrastructure thus sintered at a sufficient temperature.
Patent DE-3789737-T2 (DE)
Inventor: MCQUIRE JOHN FINBARR
IPC: G07F7/08
Filed: 1987-07-24
Granted: 1994-08-18
Abstract: A point-of-sale credit card verifier (1) for checking the validity of cards, such as credit cards, comprises means for non-destructively storing information (3) on invalid credit cards for comparison with information which is read from a card presented for use. The information on invalid credit cards is transmitted by signals embedded in a VHF stereo radio broadcast from a broadcast station which is received by a VHF receiver/demodulator (10). A credit card sensor (4) and control maintains the verifier switched off unless a credit card is to be read. The verifier is switched on when information is about to be broadcast from a broadcast station. The verifier operates quickly and independently of telecommunications networks.
Patent DE-3850654-T2 (DE)
Inventor: GOULD HANNAH
IPC: C07K14/00
Filed: 1988-11-18
Granted: 1994-12-15
Abstract: A polypeptide competitor or analogue for human Immunoglobulin E (IgE) low affinity sites comprises a polypeptide which has a sequence of amino acid which has a sequence of amino acids which is shown in Table I. This amino acid sequence corresponds to amino acids 340 to 439 of the epsilon heavy chain of IgE. A particularly preferred polypeptide competitor has a sequence of amino acids corresponding to amino acids 340 to 547 of the epsilon heavy chain of IgE as set out in Table V herein, which also shows the corresponding DNA sequence coding therefor. Such a polypeptide may also include additional short sequences at the beginning and/or end of the core sequence which are physiologically harmless and do not contribute to the ability of the core sequence to compete with native IgE for the low affinity receptor sites on human cells. The polypeptide may be produced synthetically or by expression from Escherichia coli containing a plasmid having a DNA segment coding for the polypeptide.