Patent SG-11201407252U-A (SG)
Title: Method for controlling the size of solid-state nanopores
Inventor: GODIN MICHEL
IPC: G01N33/487
Filed: 2013-05-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/167952 A1 (51) International Patent Classification: B01D 67/00 (2006.01) G01B 7/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/000884 7 May 2013 (07.05.2013) English English (30) Priority Data: 61/643,651 61/781,081 7 May 2012 (07.05.2012) US 14 March 2013 (14.03.2013) US (71) Applicant: THE UNIVERSITY OF OTTAWA [CA/CA]; 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). (72) Inventors: GODIN, Michael; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). BEAMISH, Eric; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). TABARD- COSSA, Vincent; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). KWOK, Wing Hei; The University of Ottawa, 3042-800 King Ed­ ward, Ottawa, Ontario KIN 6N5 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: METHOD FOR CONTROLLING THE SIZE OF SOLID-STATE NANOPORES ^27 CJ o\ i> i-H cn i-H o CJ O £ FIG. 2 (57) Abstract: A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and low a value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied the to membrane when the size of the nanopore corresponds to a desired size.