baber/WOPTO huggingface dataset:
Patent CA-3067333-A1 (CA)
Title: Enzymatic replacement therapy and antisense therapy for pompe disease
Inventor: VAN DER WAL ERIK
IPC: C12N15/113
Filed: 2018-06-14
Abstract: The invention relates to method for repairing aberrant; splicing, wherein such aberrant: splicing is caused by the pressence of a natural pseudo exon, comprising blocking of either the natural cryptic 3' splice site or t he natural cryptic 5' splice sit e of said natural pseudo exon with an antisense oligomeric compound (AON). Further, the invention comprises an antisense oligomeric compound targeting SEQ ID NO: 1 or SEQ ID NO: 171, preferably selected from the sequences of SEQ ID NO: 267 - 2040, sequences that are complementary to said sequences or sequences that have an identity of 80% with said sequences or the complementary sequences. The invention further envisages the use of two antisense oligomeric compounds, a first AON targeting SEQ ID NO: 1 and a second targeting AON or SEQ ID NO: 171. These AONs are specifically for use in the treatment of Pompe disease. It is an aspect of the invention that antisense therapy using the above AONs or combinations thereof is used in combination with ERT.
Patent CA-3068398-A1 (CA)
Inventor: OKITSU NAOKO
IPC: C12N5/10
Filed: 2018-07-02
Abstract: Le problème à résoudre par la présente invention est de fournir un procédé de production d'une flavone possédant un groupe malonyl ajouté au glucose situé en position -7 dans celui-ci à l'aide d'un polynucléotide codant pour une protéine qui possède une activité permettant de transférer un groupe malonyl à la position -6 dans le glucose situé en position -7 dans le 7-glucoside de flavone, et de produire une variété de plantes qui contient une flavone possédant un groupe malonyl ajouté au glucose situé en position -7 en tant que co-pigment et pouvant par conséquent présenter une couleur de fleur modifiée, de préférence une couleur de fleur plus bleue que les couleurs des variétés existantes. On utilise un polynucléotide qui est choisi dans le groupe constitué par : (a) un polynucléotide qui comprend la séquence nucléotidique représentée par SEQ ID NO : 1 ; (b) un polynucléotide qui peut s'hybrider avec un polynucléotide comprenant une séquence nucléotidique complémentaire de la séquence nucléotidique représentée par SEQ ID NO: 1 dans des conditions stringentes et code pour une protéine possédant une activité permettant de transférer un groupe malonyl à la position -6 dans le glucose situé en position -7 dans le 7-glucoside de flavone ; (c) un polynucléotide qui code pour une protéine comprenant la séquence d'acides aminés représentée par SEQ ID NO : 2 ; et (d) un polynucléotide qui code pour une protéine comprenant une séquence d'acides aminés produite par suppression, substitution, insertion et/ou ajout d'un ou de plusieurs résidus d'acides aminés dans la séquence d'acides aminés représentée par SEQ ID NO : 2 et possédant une activité permettant de transférer un groupe malonyl à la position -6 dans le glucose situé en position -7 dans le 7-glucoside de flavones ; et autres.
Patent CA-3070329-A1 (CA)
Title: Neck exercise device
Inventor: BAKR MOUSSA
IPC: A63B23/02
Filed: 2020-01-30
Abstract: ABSTRACT An isometric/isotonic neck exercise device designed to attach around a person's head, at the forehead level as would a typical headband be worn. Attached to this head band as an integral component of this device to provide the medium by which the device can perform the function for which it is designed, is a nylon strap piece hanging down the side of the user's chin that includes single alloy "D" configuration ring for accessory attachment continuity and at four opposing positions there are double "D"  configuration rings for accessory attachment continuity. Once the device is secured in place on the user's head, accessory resistance band/s with coupler on both ends is used to perform the desired exercise. one coupler end of the resistance tube attached to the head band and the other coupler end of the resistance tube attached to a pulley hand grip, which will provide a multitude of exercises that focus on all muscle groups and tendons in the neck, mid and upper spine to specifically and dramatically improve mobility and motion, for strength, fitness and rehabilitation purposes at levels which have not previously been obtained.
Patent CA-3070994-A1 (CA)
Title: Welding applicator and method of application
Inventor: SCOTCHMER NIGEL
IPC: B23K9/29
Filed: 2020-02-05
Abstract: A welding rod assembly has a seat, a chuck, and a welding rod. The chuck has a socket for the welding rod. The seat has a passageway having an inlet and an outlet, and a fluid conduit through the seat. The apparatus that has a power supply having a main control unit, and a welding electrode. It has synthetic discharge signal generator programmed to produce DC discharges as output electrical signals from the power supply. Each discharge has a voltage, charge, starting time and polarity. The discharges define a synthetic AC output. It has an output polarity reversing switch. The apparatus includes three output terminals, a first of the output terminals being connected to the welding electrode, a second of said output terminals and a third of said output terminals having respective workpiece connections.
Patent CA-3072924-A1 (CA)
Inventor: Song Guo Qiang
IPC: D03D1/00
Filed: 2020-02-18
Abstract: Un tissu tissé pour les sièges est constitué de chaînes et de trames tissées en un motif de 4 vers le haut et de 4 vers le bas, la densité de chaînes étant de 33,8 bandes par unité de longueur et la densité de trames étant de 7,1 bandes par unité de longueur. Les chaînes et les trames sont toutes faites de polypropylène.
Patent CA-3072929-A1 (CA)
Title: Intelligent mechanical linkage performance system
Inventor: RAJ ANTHONY MARIA THOMAS BENNY MICHAEL
IPC: G05D3/12
Filed: 2020-02-19
Abstract: A work machine having a controller configured to receive a first position signal from a first boom position sensor, a second position signal from a second boom position sensor, and a load signal from the load measuring device, wherein the controller is further configured to calculate a map of hydraulic capacities within an envelope of movement for one or more of a first and a second actuators based on the first position signal, the second position signal, and the load signal, and generate a lift path of movement for the pin through at least a portion of the envelope based on the hydraulic capacities, wherein the movement envelope being smaller than the envelope.
Patent CA-3074059-A1 (CA)
Inventor: MICHELI FABRIZIO
IPC: C07D498/04
Filed: 2018-08-31
Abstract: There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.
Patent CA-3077269-A1 (CA)
Title: Procede permettant d`eviter un impact sans perte de controle et systeme d`evitement d`impact sans perte de controle
Inventor: ROSENBERG NICKY
IPC: B64D45/04
Filed: 2020-03-27
Abstract: Une méthode pour éviter limpact sans perte de contrôle (CFIT) comprend une étape visant à doter un aéronef dun capteur surveillé par radar positionné dans un sens angulaire dirigé vers lavant et vers le bas, de sorte à détecter les objets au sol devant laéronef. Le radar doit avoir une portée dau moins 10 km. Une unité de traitement surveille le capteur surveillé par radar. Un affichage reste en mode inactif jusquà ce que le capteur surveillé par radar détecte un objet au sol correspondant aux paramètres prédéterminés. Lorsque le capteur détecte un tel objet, lunité de traitement est programmée pour commuter laffichage en mode actif et afficher une représentation graphique de lobjet au sol. La méthode met le pilote en alerte avec un avertissement accentué et axé suffisamment tôt pour lui permettre de prendre la mesure dévitement appropriée pour éviter lobstacle au sol.
Patent CA-3077289-A1 (CA)
Title: Manifold for hydraulic fracturing blender and other applications
Inventor: BREZDEN JAMES RYAN
IPC: F16L41/02
Filed: 2020-03-27
Abstract: A modular fluid-carrying manifold apparatus is provided for use in hydraulic fracturing blenders and other devices. A manifold can include one or more interchangeable sections. Each section may have a flat front face with ports cut into the front face. Components such as valves and hammer unions are directly removably connected to the ports via bolts. This eliminates the need for welded-on piping. Removable, wear-resistant inserts can be located in the ports. The removable components may be considered consumable and replaced when worn out.
Patent CA-3079059-A1 (CA)
Inventor: SHEPS TAL
IPC: A61F2/24
Filed: 2018-10-26
Abstract: L'invention concerne un implant ayant un corps d'implant, un dispositif de préhension, une poche élastique et un élément allongé. La poche peut être couplée au dispositif de préhension, peut avoir une première partie et une seconde partie, peut avoir un état contracté vers lequel la poche est sollicitée élastiquement, et peut être étirable de manière réversible dans un état étiré. L'élément allongé peut avoir une première partie d'extrémité couplée au corps d'implant, une seconde partie d'extrémité fixée à la seconde partie de la poche, et une partie intermédiaire s'étendant (i) à partir de la seconde partie d'extrémité, à travers la poche jusqu'à la première partie de la poche, et (ii) hors de la poche jusqu'à la première partie d'extrémité. Dans au moins un état du dispositif de préhension, la partie intermédiaire peut coulisser à travers le dispositif de préhension et dans la poche. L'invention décrit également d'autres modes de réalisation.
Patent CA-3079190-A1 (CA)
Title: Methods and systems for detection of somatic structural variants
Inventor: GENOVESE GIULIO
IPC: G01N33/50
Filed: 2018-10-17
Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.
Patent CA-3079220-A1 (CA)
Title: Split flap display
Inventor: COURTNEY MICHAEL XAVIER
IPC: H05K5/02
Filed: 2018-10-25
Abstract: A split flap display is provided. The display includes a wall frame mounted on a wall. The wall frame includes a plurality of panel guides extending outwardly therefrom, a breakout board mounted thereon, and a plurality of cantilevered snap locks extending outwardly therefrom. An array of carousel modules is mounted in a cabinet. The array includes a single row and a plurality of columns. The cabinet includes a locking slot adapted to relesably receive a free end of one of the plurality of cantilevered snap locks and a slide lock configured for longitudinal translation engagement with the free end of one of the plurality of cantilevered snap locks, such that translation of the slide lock displaces the free end of the cantilevered snap lock out of engagement with the locking slot. When the free end of the cantilevered snap lock is out of engagement with the locking slot, the array can be removed from the wall frame.
Patent CA-3080080-A1 (CA)
Inventor: FAGOT-REVURAT LIONEL
IPC: H01Q1/22
Filed: 2018-10-26
Abstract: The invention relates to a parameter measurement system for a mounted assembly comprising an electronic device for measuring the parameters of the mounted assembly and a connecting interface made of elastomeric material including the electronic device. The electronic measurement device comprises: - a UHF radiofrequency antenna; - an electronic card with an electronic chip coupled to the UHF radiofrequency antenna, a sensor for measuring the parameter of the mounted assembly, a microcontroller and an electrical circuit. The measurement system is characterised in that it comprises a ground plane connected to the electronic card, in that the electronic card comprises an energy manager and a capacitive element, in that the coupling between the electronic chip and the UHF radiofrequency antenna is an electrical coupling and in that the electronic chip, the microcontroller and the measurement sensor are components with low energy consumption.
Patent CA-3080975-A1 (CA)
Inventor: MORETTO ALBERTO
IPC: A61K31/165
Filed: 2018-10-30
Abstract: The present invention relates to pharmaceutical compositions comprising safinamide and, more particularly, to taste-masked particles comprising said active ingredient or pharmaceutically acceptable salts thereof, oral dosage forms that include said particles and a process for preparing them.
Patent CA-3082835-A1 (CA)
Inventor: TSAPIS NICOLAS
IPC: C08F20/56
Filed: 2018-11-16
Abstract: The invention relates to novel prodrugs of active molecules. These prodrugs enable in particular the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs of the invention comprise an active ingredient covalently bonded with a polymer chain, preferably a hydrophilic and/or heat-sensitive polymer chain. The invention relates in particular to polymer prodrugs comprising a polymer chain at least partly formed of monomer of acrylamide or a derivative thereof, said polymer comprising a proximal portion and a terminal portion; a first pharmaceutically active molecule covalently coupled to the proximal portion of the polymer; and optionally a second pharmaceutically active molecule covalently coupled to the terminal portion of the polymer.
Patent CA-3083148-A1 (CA)
Title: Cost-based optimizer, and cost estimation method and device thereof
Inventor: XIA LI
IPC: G06F16/2453
Filed: 2018-11-22
Abstract: A cost-based optimizer, and a cost estimation method and a device thereof. The method comprises: when it is determined that acquired statistics information is incomplete, determining a corresponding cost estimation manner according to an operation type of an operation tree relying on the statistics information (S11); determining a cost estimate of the corresponding operation type based on the cost estimation manner (S12); and determining an accumulated cost estimate of the operation tree according to the cost estimate corresponding to the operation type relying on the statistics information and a cost estimate corresponding to an operation type not relying on the statistics information (S13). Thus, cost estimation can be performed for the creation of a temporary table and a subquery during operation, so that the scenario of massive data is not restricted by a data scale.
Patent CA-3084443-A1 (CA)
Title: Methods and systems for identifying hybrids for use in plant breeding
Inventor: CHAVALI SRINIVAS PHANI KUMAR
IPC: A01H1/02
Filed: 2018-12-07
Abstract: Exemplary methods for identifying hybrids for use in a plant breeding pipeline are disclosed. One exemplary computer-implemented method includes accessing a data structure including data representative of a pool of hybrids and determining a prediction score for at least a portion of the hybrids included in the pool based on the data included in the data structure. The prediction score is indicative of a probability of selection and/or a probability of success of the hybrid based on historical data. The method further includes selecting a group of hybrids from the pool based on the prediction score, identifying a set of hybrids, from the group of hybrids, based on an expected performance of the set of hybrids and/or one or more factors associated with the hybrids and/or lines making up the hybrids, and also directing the set of hybrids to a further iteration or different phase in the breeding pipeline.
Patent CA-3087073-A1 (CA)
Title: Instruments chirurgicaux articules
Inventor: FELIX AUGUSTUS
IPC: A61B17/064
Filed: 2019-01-03
Abstract: L'invention concerne des instruments chirurgicaux articulés (2). Dans un mode de réalisation, un instrument chirurgical (2) peut comprendre un ensemble arbre allongé (6) comprenant une partie articulable (8) mobile entre une configuration non articulée et une configuration articulée. Des premier (32) et second (34) arbres d'articulation de l'ensemble arbre allongé (6) peuvent être agencés coaxialement et fixés axialement à un point de fixation situé de manière distale à partir de la partie articulable (8). Des parties proximales des premier (32) et second (34) arbres d'articulation peuvent être déplaçables dans des directions opposées pour articuler la partie articulable à partir de la configuration non articulée vers la configuration articulée. Dans un autre mode de réalisation, une commande d'articulation (10) peut être mobile d'une première position vers une seconde position pour déplacer un verrou d'articulation (36) à partir d'une configuration verrouillée vers une configuration déverrouillée pour permettre l'articulation sélective d'un instrument chirurgical (2). Le verrou d'articulation (36) peut également être mobile à partir de la seconde position vers une troisième position pour articuler l'instrument chirurgical (2).
Patent CA-3087211-A1 (CA)
Inventor: PASSERON THIERRY
IPC: C07D215/44
Filed: 2019-01-04
Abstract: The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R'1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R'1 is H, R1 is OCH3 then R'1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.
Patent CA-3088724-A1 (CA)
Inventor: IWASHITA YUJI
IPC: C08G63/127
Filed: 2019-04-10
Abstract: The present invention addresses the problem of providing: a copolyester which is effective as a binder component for aqueous paints; and a copolyester aqueous dispersion. The present invention also addresses the problem of providing an aqueous paint copolyester and a resin composition which have excellent storage stability, surface hardness, flexibility, and water resistance in an aqueous paint composition using the copolyester resin. Provided is a copolyester (A) having polycarboxylic acid components and polyalcohol components as copolymerization components, wherein the total content of aromatic polycarboxylic acid components and alicyclic polycarboxylic acid components is 100 mol% with respect to 100 mol% of the total amount of polycarboxylic acid components, the content of glycol component (a), which has two hydroxyl groups bonded by an alkylene group having 5 or less carbon atoms and has an alkyl group having 3 or more carbon atoms as a side chain of the alkylene group, is 10-40 mol% with respect to 100 mol% of the total amount of polyalcohol components, and the copolyester has a glass transition temperature of -10 to 20°C and an acid value of 150-400 equivalents/ton.
Patent CA-3089629-A1 (CA)
Title: Solidifying liquid amine oxide, betaine, and/or sultaine surfactants with a carrier
Inventor: LO WENDY
IPC: C11D1/92
Filed: 2019-01-28
Abstract: The invention relates to solidification of liquid amine oxide, betaine, and/or sultaine surfactants with a carrier to form a solidified surfactant composition. In particular, the invention relates to solidification of liquid surfactants utilizing drying device(s), wherein the feed composition contains at least one liquid surfactant and a carrier to form a solidified surfactant composition. The solidified surfactant compositions can be useful in various cleaning compositions.
Patent CA-3091990-A1 (CA)
Inventor: BREEN SCOTT M
IPC: B21D24/00
Filed: 2020-09-03
Abstract: A modular guided keeper base, guided keeper assembly, and related method includes a modular guided keeper base that mounts to a die member. The guided keeper base has an integrated stop for guide pin retention. The guided keeper base can also accommodate a variety of bushings within the base. The guided keeper base is attached to a die member using a mounting flange(s). Mounting fasteners pass through the fastener holes in the mounting flanges and are anchored in the die member to securely retain the guided keeper assembly in place. A retainer ring is mounted in an associated groove in the base over the heads of the mounting fasteners to prevent unintentional unfastening of the fasteners from the die member.
Patent CA-3092505-A1 (CA)
Title: A turbomachine sealing system and turbomachine including the sealing system
Inventor: MEI LUCIANO
IPC: F01D11/00
Filed: 2019-03-12
Abstract: A sealing system is described for effecting a seal of a gap (G1; G2) in a turbomachine (1) between a first structural member (21; 23) and a second structural member (31). The sealing system includes a sealing apparatus comprising a sealing member (47; 77) comprising a first edge portion (49; 79) and a second edge portion (51; 81). The two edge portions are parallel to one another and the first edge portion (49; 79) forms a pivoting connection to the first structural member (21; 23). The first structural member (21; 23) further comprises a seat (55; 85) rotatably housing the first edge portion (49; 79) of the sealing member (47; 77). The second edge portion (51; 81) comprises a curved contact surface (51.1; 81.1), in sealing contact with a contact surface (67; 97) of the second structural member (31). Further disclosed herein is a gas turbine engine (1) with a combustor liner (31) and a sealing arrangement to seal a gap (G1; G2) between the combustor liner (31) and the turbine nozzles of the first turbine stage.
Patent CA-3095320-A1 (CA)
Inventor: OMURA TAKESHI
IPC: H01F41/02
Filed: 2019-03-29
Abstract: The present invention reduces vibration of an iron core and ameliorates the noise of a transformer. An iron core for a transformer, said iron core having a plurality of oriented electromagnetic steel sheets laminated therein, wherein in at least one of the oriented electromagnetic steel sheets, (1) the oriented electromagnetic steel sheet has a region in which a closure domain is formed in a direction intersecting a rolling direction, and a region in which a closure domain is not formed, and (2) the area ratio R of a region with regard to the entire oriented electromagnetic steel sheet is 0.10-30%, said region experiencing, when excited in the rolling direction at a maximum magnetic flux density of 1.7T and a frequency of 50Hz, at least 2×10-7 less shrinkage at a maximum displacement point than the shrinkage of the region in which a closure domain is not formed.
Patent CA-3098765-A1 (CA)
Inventor: KANG LISHAN
IPC: C12P21/02
Filed: 2019-09-20
Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein.  The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.