Patent SG-11201809561W-A (SG)
Title: 9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (uti) treatment
Inventor: MANLEY AMY
IPC: C07C237/26
Filed: 2017-05-02
Abstract: Filing Language: (26) Publication Language: (30) Priority Data: 62/330,436 62/350,332 62/415,988 62/422,852 02 May 2017 (02.05.2017) English English 02 May 2016 (02.05.2016) US 15 June 2016 (15.06.2016) US 01 November 2016 (01.11.2016) US 16 November 2016 (16.11.2016) US (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 November 2017 (09.11.2017) WIPO I PCT omit IIl Hot o omoiflom oimIE (10) International Publication Number WO 2017/192516 Al (51) International Patent Classification: A61K 31/65 (2006.01) CO7C 237/26 (2006.01) (21) International Application Number: PCT/US2017/030546 (22) International Filing Date: Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (71) Applicant: PARATEK PHARMACEUTICALS, INC. [US/US]; 75 Park Plaza, 4th Floor, Boston, MA 02116 (US). (72) Inventors: MANLEY, Amy, L.; 44 North Calder Way, Phoenixville, PA 19460 (US). TZANIS, Evangelos, L.; 3906 White Stone Road, Newtown Square, PA 19073 (US). GARRITY-RYAN, Lynne; 17 Laurel Street, Melrose, MA 02176 (US). TANAKA, S., Ken; 10 Noyes Street, Need- ham, MA 02492 (US). = (74) Agent: HANLEY, Elizabeth, A. et al.; McCarter & Eng- lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF IN URINARY TRACT INFECTION (UTI) TREATMENT C (57) : The disclosed invention provides a method for treating urinary tract infection (UTI) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.