Patent SG-11201900745V-A (SG)
Title: Substituted thiazolo-pyridine compounds as malt1 inhibitors
Inventor: KUKREJA GAGAN
IPC: C07D513/04
Filed: 2017-07-28
Abstract: International Patent Classification: CO7D 513/04 (2006.01) A61P 37/00 A61K 31/429 (2006.01) A61P 17/00 A61P 35/00 (2006.01) A61P 19/00 (2006.01) (2006.01) (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIPO I PCT °mons °nolo ovum Mo mo mnio oimIE (10) International Publication Number WO 2018/020474 Al PCT/IB2017/054612 (22) International Filing Date: 28 July 2017 (28.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201621026107 29 July 2016 (29.07.2016) IN (71) Applicant: LUPIN LIMITED [IN/IN]; Kalpataru Inspire, 3rd Floor, Off Western Express Highway, Santacruz (East), Maharashtra, Mumbai 400 055 (IN). (72) Inventors: KUKREJA, Gagan; Lupin Limited (Research Park), 46A / 47A Village Nande, Taluka Mulshi, Ma- harashtra, Pune 412115 (IN). IRLAPATI, Nageswara, Rao; Lupin Limited (Research Park), 46A / 47A Village Nande, Taluka Mulshi, Maharashtra, Pune 412115 (IN). JAGDALE, Arun, Rangnath; Lupin Limited (Research Park), 46A / 47A Village Nande, Taluka Mulshi, Maha- rashtra, Pune 412115 (IN). DESHMUKH, Gokul, Keru- ji; Lupin Limited (Research Park), 46A / 47A Village Nande, Taluka Mulshi, Maharashtra, Pune 412115 (IN). VYAVAHARE, Vinod, Popatrao; Lupin Limited (Re- search Park), 46A / 47A, Village Nande, Taluka Mul- shi, Maharashtra, Pune 412115 (IN). KULKARNI, Kiran, Chandrashekhar; Lupin Limited (Research Park), 46A / 47A, Village Nande, Taluka Mulshi, Maharashtra, Pune 412115 (IN). SINHA, Neelima; Lupin Limited (Research Park), 46A / 47A, Village Nande, Taluka Mulshi, Maha- rashtra, Pune 412115 (IN). PALLE, Venkata, P.; Lupin Limited (Research Park), 46A / 47A, Village Nande, Talu- ka Mulshi, Maharashtra, Pune 412115 (IN). KAMBOJ, Rajender, Kumar; Lupin Limited (Research Park), 46A / 47A, Village Nande, Taluka Mulshi, Maharashtra, Pune 412115 (IN). (74) Agent: MAJUMDAR, Subhatosh et al.; S. Majumdar & Co., 5 Harish Mukherjee Road, State of West Bengal, Kolkata 700 025 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) 1-1 7 1 - (54) Title: SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS O 71' O O C R 2 H H R' ° (I) (57) : Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammato- ry diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also dis- closed are pharmaceutical compositions containing a compound of the invention and a method of treating a patient for an autoimmune or an inflammatory disease or disorder, for example, a cancer, by administering a compound of the invention.