baber/WOPTO huggingface dataset:
Patent PT-1406667-E (PT)
Title: Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals
Inventor: RENZI PAOLO
IPC: C12N15/09
Filed: 2002-07-08
Abstract: The invention relates to the use of nucleotide substitutes for increasing the in vivo efficacy of nucleic acid molecules and also for inhibiting inflammation in mammals. More particularly, the present invention relates to the use of 2′6′ diaminopurine (DAP) and analogs thereof per se in anti-inflammatory compositions, and also for preparing nucleic acid molecules having an increased in vivo physiological efficiency and a reduced toxicity as compared to conventional oligos. The invention is particularly useful for the preparation of antisense oligonucleotides for treating pulmonary/respiratory diseases such as cystic fibrosis, asthma, chronic bronchitis, chronic obstructive lung disease, eosinophilic bronchitis, allergies, allergic rhinitis, pulmonary fibrosis, adult respiratory distress syndrome, sinusitis, respiratory syncytial virus or other viral respiratory tract infection and cancer.
Patent PT-1444400-E (PT)
Title: Method of making an anti-vibration plate for a vibration damping system
Inventor: ASMUSSEN JOHN CHRISTIAN
IPC: E01B19/00
Filed: 2002-11-12
Abstract: The invention relates to a vibration damping system, which comprises an anti-vibration plate in the form of a plate having a first and a second major surface, wherein the first major surface may preferably be covered with a layer of surfactant-free geotextile. The anti-vibration plate comprises one or more layers, preferably a top layer and one or more bottom layers. The top layer and the one or more bottom layers both comprise mineral fibres and a binder. Furthermore, it is essential that the anti-vibration plate is preferably obtainable by a method comprising the step of subjecting an area of the opposite surfaces of the plate to a compression treatment in one or more steps, which compression treatment is sufficient to reduce the static and/or the dynamic stiffness of the plate by at least 10 %, preferably at least 15 %, more preferably at least 20 % compared to the static and/or dynamic stiffness prior to the compression. The invention also relates to the method of applying a vibration damping system and the use of a vibration damping system.
Patent PT-1465861-E (PT)
Title: Alpha-(n-sulphonamido)acetamide derivatives as beta-amyloid inhibitors
Inventor: PARKER MICHAEL F
IPC: C07D413/04
Filed: 2002-12-20
Abstract: There is provided a series of novel alpha-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of beta-amyloid peptide (beta-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.
Patent PT-1327393-E (PT)
Title: Process and installation for preparation of heads of lettuce
Inventor: BEAUMONT LAURENT
IPC: B26D7/18
Filed: 2003-01-13
Abstract: The procedure is carried out by a machine with a number of working posts performing a series of stages. In the first stage (I) each head (TS) is gripped by its stalk (Q) using a clamp (2) on a support (1). In a second stage (II) the outer leaves (FE) are cut at the base; in a third (III) the outer leaves are cut round the middle, and in a fourth (IV) they are removed. In a fifth stage (V) the stalk is cut away from the head, leaving the head, whole or cut into sections, ready for use. The stages use a variety of cutting, suction and blowing operations.
Patent PT-1506339-E (PT)
Title: Paper machine fabric
Inventor: TAIPALE SEPPO
IPC: D21F1/10
Filed: 2003-05-02
Abstract: A paper machine fabric comprising at least two separate layers formed using at least two separate yarn systems: one constituting the paper side and comprising machine direction and cross machine direction yarns and the other constituting the machine side and comprising machine direction and cross machine direction yarns, the yarn systems being arranged to form independent structures in both directions of the fabric. The structures are bound together with binder yarns, a binder yarn being arranged to form part of the weave of a layer on the paper side surface and arranged to be interwoven with a layer of the machine side by being interwoven under at least one yarn in the machine side layer. The number of machine direction yarns in the layer constituting the machine side is larger than the number of machine direction yarns in the layer constituting the paper side.
Patent PT-1611416-E (PT)
Title: Navigation device and method for displaying alternative routes
Inventor: PINKUS AYAL
IPC: G06F3/0488
Filed: 2004-02-26
Abstract: A navigation device has a route ire calculation function. This is activated by the user touching the screen to task away from the normal navigation map mode to a menu screen which displays multiple types of route re-calculation options.
Patent PT-1820792-E (PT)
Title: Process for the preparation of adamantanamines
Inventor: SCHICKANEDER CHRISTIAN
IPC: C07C209/62
Filed: 2006-02-21
Abstract: The present invention concerns a process for the manufacture of an adamantanamine of formula   
wherein R, R' and X are as defined in the claims, which comprises 
(i) reacting a compound of formula   
with thiourea; 
(ii) subjecting the resulting compound of formula   
to an acid treatment and 
(iii) isolating the resulting adamantanamine or a hydrohalogenide thereof.  According to the process of the invention, valuable pharmaceuticals are obtainable, such as Memantine hydrochloride (R,R' = methyl), an uncompetitive NMDA( N -methyl-D-aspartate) receptor antagonist used as a new treatment for Alzheimer's disease, or Amantadine hydrochloride (R,R' = hydrogen) used as an antiviral or in the treatment of Parkinson's disease.
Patent PT-1962925-E (PT)
Title: Device for administration
Inventor: MEJLHEDE SIGNE THORNING
IPC: A61M5/158
Filed: 2006-12-22
Abstract: A device for delivering fluid, comprising an injection part (1), a fluid delivery part (3,4), and a base plate (10), wherein the fluid delivery part and the base plate can be separated and rejoined, the fluid delivery part comprising a reservoir (4) having an outlet, transfer means, and a housing (3), the injection part comprising a cannula part comprising a body with a through going opening provided with a cannula (9) configured to extend past the proximal side of the base plate, the base plate comprising means for fixation of the base plate to the skin of the user, wherein the injection part comprises a first part (1a) which is fastened unreleasably to the base plate and a second part (1b) comprising the cannula part, the second part being configured to lock to the first part upon insertion of the second part.
Patent PT-2035239-E (PT)
Title: Method for producing three-dimensionally structured surfaces
Inventor: STAHLHUT OLIVER
IPC: B23K26/08
Filed: 2007-05-07
Abstract: A method for producing three-dimensionally structured surfaces of objects, the object surface being created as a reproduction of a three-dimensionally structured original surface with the aid of a machining tool. Accordingly, the topology of the original surface is first determined, a measured depth value being assigned to each surface or grid element, creating a depth map of the original surface. The depth values are evaluated in terms of their influence on the reflective properties of the surface elements and the reflective properties are stored in the form of parameters. The depth values are then modified in accordance with the reflective values and are used as topological data for the electronic control of a machining tool.
Patent PT-2022682-E (PT)
Title: Automobile body structure and vehicle comprising such a structure.
Inventor: JAMBUT JEAN-FRANCOIS
IPC: B60R19/34
Filed: 2008-07-28
Abstract: The structure has case parts displaceable with respect to one another along a longitudinal direction (X). An energy absorber (40) has a tearable unit (41) connected to one of the parts. A locking device (60) has a locking unit (62) movable between a locking position and a retracted position. The device has a blocking unit (67) controlled for being displaced between an active position in which the unit (67) locks the unit (62) in locking position and an inactive position in which the unit (67) does not interfere with the unit (62).
Patent PT-2077174-E (PT)
Title: Cutting insert tool holder, and related method
Inventor: HARTMAN THOMAS B
IPC: B23C5/10
Filed: 2007-12-07
Abstract: A peripheral cutting tool comprises a tool holder including at least one insert pocket. A cutting insert may be located in the at least one insert pocket of the tool holder such that a midpoint of the main cutting edge of the cutting insert is located in a radial plane comprising the axis of rotation of the tool holder, and wherein a support plane including a bottom surface of the insert pocket is perpendicular to a secondary radial plane. The secondary radial plane comprises the axis of rotation of the tool holder and is perpendicular to the primary radial plane. A method is also provided for positioning a cutting insert comprising a main cutting edge in an insert pocket of a tool holder of peripheral cutting tool.
Patent PT-2146209-E (PT)
Title: Neurodegenerative markers for alzheimer`s disease
Inventor: MYINT AYE MU
IPC: G01N33/68
Filed: 2006-03-30
Abstract: The present invention relates to methods for detecting Alzheimer's disease (AD) comprising the steps of measuring the concentration of at least one  in vivo  degradation product of tryptophan. Further, the present invention relates to the use of said values as predictive markers for the detection of Alzheimer's disease and a kit containing means for detecting said values.
Patent PT-2051145-E (PT)
Title: Toner supply container and toner supply system
Inventor: MURAKAMI KATSUYA
IPC: B41J27/16
Filed: 2002-02-18
Abstract: A toner supply container (1) detachably mountable to an image forming apparatus (100) comprises a container main body (1A) having an inner space adapted to contain toner and an opening (1a) adapted to permit discharge of the toner out of said container (1), a sealing member (2) having a sealing portion (2b) adapted to seal said opening (1a) and a coupling engagement portion (2c) adapted to engage with a cylindrical portion (20) provided in the image forming apparatus (100). The coupling engagement portion (2c) includes a locking portion (3) adapted to be locked with the cylindrical portion (20) to unseal said opening (1a) with relative movement of said sealing portion (2b) and said container main body (1A) away from one another, an elastically deformable supporting portion (2f) adapted to support said locking portion (3) so as to cause said locking portion (3) to displace with relative movement between said locking portion (3) and the cylindrical portion (20) in a direction of overlapping therebetween, and a releasing portion (4) adapted to receive from the image forming apparatus (100) a releasing force for releasing engagement between said locking portion (3) and the cylindrical portion (20) by displacement of said locking portion (3b) with elastic deformation of said supporting portion (2f).
Patent PT-2240622-E (PT)
Title: Method for producing a component from a steel product provided with an al-si coating and intermediate product of such a method
Inventor: LENZE FRANZ-JOSEF
IPC: C23C2/28
Filed: 2009-01-29
Abstract: A process for producing a component from a steel product coated with a protective Al—Si coating, and an intermediate product that arises during the course of such a process and that can be used to produce components of the type concerned here. The steel product coated with the Al—Si coating, undergoes a first heating stage in which the temperature and the duration of the heat treatment are set such that the Al—Si coating is only partially pre-alloyed with Fe from the steel product. Then, the steel product, in a second heating stage, is heated to a heating temperature, above the Ac1 temperature, at which the steel product has an at least partially austenitic structure, wherein the temperature and the duration of the second heating stage are set such that the Al—Si coating is fully alloyed with Fe from the steel product. After the steel product is heated to the heating temperature, it is shaped to form the component and the component obtained is cooled in a controlled manner, in order to obtain a martensitic structure.
Patent PT-2300261-E (PT)
Title: Rail vehicle which has a permanent magnet synchronous motor as traction motor
Inventor: SCHAEFER-ENKELER ANDREAS
IPC: B60L7/06
Filed: 2009-07-02
Abstract: A rail vehicle has a permanent-magnet synchronous motor as its traction motor. A switching apparatus is arranged between a converter and the traction motor, connects the traction motor to the converter in the driving mode and connects the traction motor to at least one braking resistance during generator operation of the traction motor. The switching apparatus can be operated pneumatically and is for this purpose connected to a main air control line of a compressed-air braking system. In the driving mode, when the pressure in the main air control line is greater than a threshold value, the traction motor is connected to the converter. For braking, when the pressure in the main air control line is less than the threshold value, the traction motor is connected to the at least one braking resistance.
Patent PT-644245-E (PT)
Inventor: COLLONG WILFRIED
IPC: C09D5/44
Filed: 1994-09-17
Abstract: Aqueous dispersions, coating compositions prepared therefrom, and use thereof as cationic deposition coating materials. The dispersions comprise hydroxyl-containing, at least partially neutralised amino-epoxy resins and crosslinking agents, at a solids content of from 30 to 45% by weight with particle sizes of the dispersed phase of up to 1000 nm and with a solvent content of from 0 to 5% by weight. They are obtainable by the mixing, or at least partial precondensation in the low-solvent condition, at temperatures of from 50 to 140 DEG C, of   I. from 95 to 50% by weight of one or more essentially solvent-free, hydroxyl-containing amino-epoxy resins having tertiary amino groups with an amine number of from 30 to 120, a hydroxyl number of from 20 to 300 and a number-average molecular mass of from 1000 to 20,000, which may be present as a mixture with up to 15% by weight, based on the resin solids content of the overall component I, with one or more liquid diluents which are of limited solubility in water, are not volatile at the baking temperature and are based on polyoxyalkylenediols having at least two alkylene oxide units in the molecule, which contain at least one nucleophilic group for reaction with the crosslinking component II, the amino-epoxy resins or the mixture with the diluents containing on average from 0.3 to 5.0 mmol/g of alkylene oxide units, with II. from 5 to 50% by weight of one or more crosslinking agents, and   III. with neutralisation of the resulting mixture at temperatures of from 60 to 95 DEG C with from 0.1 to 1.0 mmol of one or more monocarboxylic acids per g of amino-epoxy resin, and dispersion at these temperatures in the presence of water.
Patent PT-709462-E (PT)
Title: Rapid and efficient regeneration of transgenic plants
Inventor: FRY JOYCE ELLEN
IPC: C12N15/82
Filed: 1995-10-25
Abstract: A rapid transformation regeneration system is disclosed. This system takes two-three months to obtain transgenic plants. Transformation efficiencies are very high. This system also has been demonstrated with several different selecting systems and is particularly useful for transforming wheat.
Patent PT-731843-E (PT)
Inventor: GUY DELLA-CIOPPA
IPC: C12N15/86
Filed: 1994-11-08
Abstract: The present invention relates to a nucleic acid sequence that encodes a fusion enzyme of tyrosinase and a tyrosinase activator protein. Further, the present invention also relates to the amino acid sequence which is encoded by the nucleic acid sequence of the fusion enzyme. The fusion enzyme may also include a linker positioned between the amino acid sequences of the tyrosinase and the tyrosinase activator protein. Still further, the present invention also relates to a vector useful for introducing the nucleic acid sequence encoding the fusion enzyme into an organism. Still further, the present invention relates to melanins made by the fusion enzyme and a method for making melanins using the fusion enzyme.
Patent PT-744409-E (PT)
Title: Platelet growth accelerator
Inventor: YAMASAKI MOTOO
IPC: A61K38/19
Filed: 1995-02-23
Abstract: The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.
Patent PT-784468-E (PT)
Inventor: BOUWSTRA JOHANNA AALTJE
IPC: A61Q19/00
Filed: 1995-09-27
Abstract: PCT No. PCT/NL95/00325 Sec. 371 Date May 28, 1997 Sec. 102(e) Date May 28, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09812 PCT Pub. Date Apr. 4, 1996Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.
Patent PT-936893-E (PT)
Inventor: WONG PATRICK S-L
IPC: A61K9/00
Filed: 1997-10-14
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
Patent PT-1033946-E (PT)
Inventor: RICHARD CANCEL
IPC: A61F2/00
Filed: 1998-11-27
Abstract: The invention provides an apparatus enabling the introduction of a prosthesis of the pad form with increased ease into the interior of the abdominal cavity and to automatically unroll it, such that its installation and stapling are easier for the practitioner. More specifically, the invention includes a device for the installation of a prosthesis in the treatment of inguinal hernias via peritoneoscopy, including an applicator essentially constituted of a substantially cylindrical tube capable of containing the prosthesis, a plunger for injecting the prosthesis from the tube at the desired site, and a spring attached to the plunger such that it is capable of attaching to the prosthesis in a detachable manner and of spreading it out when it is discharged to the exterior of the tube.
Patent PT-1036058-E (PT)
Inventor: BAXTER ANDREW
IPC: C07D493/08
Filed: 1998-12-01
Abstract: The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
Patent PT-1061940-E (PT)
Inventor: WOOD CLIVE R
IPC: A61P25/00
Filed: 1999-02-24
Abstract: Provided is the use of an effective amount of follistatin or a functional fragment thereof for the preparation of a therapeutic composition for modulating the effects of a protein on cells, wherein the protein is selected from the group consisting of growth and differentiation factor 8 (GDF-8) and bone morphogenetic protein 11 (BMP-11).
Patent PT-1086199-E (PT)
Inventor: JAESCHKE EDGAR
IPC: C11D17/00
Filed: 1999-06-04
Abstract: The invention relates to a sanitary agent for cleaning and/or disinfecting and/or releasing an odorant, said agent comprising an adhesion promoter, water anionic and/or non-ionic and/or amphoteric surface active agents and, optionally, further common constituents such as odorants, thickeners, colorants and preservatives. The adhesion promoter is selected from the group of very long or long-chained organic molecules which are hydrophilic at least in part. The hydrophilic part of the adhesion promoter interacts at least in part with the water molecules in the presence of water and becomes "sticky" so that the agent can be applied directly on the sanitary object in the presence of small amounts of water and can adhere thereto. The viscosity of the agent is of at least 15,000 mPas and the product can only be washed away completely after numerous rinsings. The invention also relates to a method for applying a sanitary agent, wherein the agent is directly applied on the surface of the sanitary object to be cleaned and adheres to said surface.
Patent PT-1107965-E (PT)
Inventor: JUNG S LEE
IPC: C07D401/12
Filed: 1999-08-25
Abstract: The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)<SUB>2 </SUB>and R<SUP>1 </SUP>to R<SUP>7 </SUP>are various substituents as selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function.
Patent PT-1137495-E (PT)
Title: Laminated pads with mechanically folded handles
Inventor: WOODS JAMES M
IPC: B05C17/00
Filed: 1999-11-19
Abstract: Multilayer disposable pads for use as wipes or applicators in various applications, including the cosmetic and personal care fields and the medical field. The pads include an absorbent base pad and a flexible handle attached either to an intermediate barrier layer or to the base pad. To form the handle, handle forming material is mechanically folded, employing a pleating/folding machine, prior to being adhered to the barrier layer or to the base pad. In one embodiment, the handle includes a graspable portion made of two facing segments which may be joined along a distal folded edge, and two handle attached portions respectively joined to the facing segments along fold lines.
Patent SG-11090-G (SG)
Title: Process for the preparation of silicon hydrides,use thereof and apparatus for carrying out the process
IPC: H01J9/20
Filed: 1990-02-14
Abstract: Silicon hydrides are produced by acid hydrolysis of ternary silicon alloys. According to the process there are made to react an industrial ternary alloy of the formula MxM2ySiz, in which M1 is a reducing metal, M2 is an alkali alkaline-earth metal, with a dilute acid selected from hydracids and orthophosphoric acid, at a concentration of 2N to 6N, by adding the ternary alloy in the form of fine powder to the acid, the reaction being preformed between ambient temperature and 90 DEG  C. The various hydrides are condensed, and separated by fractional evaporation under partial vacuum. The silicon hydrides-silane, disilane and higher polysilanes-after purification can be used as silicon vectors, depending on their chemical nature, particularly in the industries of electronic components, photovolaitic cells, photocopier drums and for frosting light bulbs by the dry method.