baber/WOPTO huggingface dataset:
Patent DE-69534061-T2 (DE)
Inventor: DEIGIN VLADISLAV ISAKOVICH
IPC: A61P17/14
Filed: 1995-06-27
Granted: 2006-04-13
Abstract: The invention is a peptide of general formula (I) X-Tyr-Y-Phe-Z-A, wherein: X represents H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, Har, D-Har, Cyt, D-Cyt; Y represents D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Har, D-Arg, D-His, D-Asp, D-Glu, D- beta -Ala, D-Orn; Z represents Ala, D-Ala, Val, D-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gly, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu,  beta -Ala, D- beta -Ala, Orn, D-Orn; and A represents OH or a substituted amide (C1-C3). According to the invention, the proposed peptide of general formula (I) is obtained by the gradual construction of a peptide chain, starting from C-terminated amino acide Z, in the form of a substituted amide or carboxyl-protected group, by addition using the method of activated ethers or mixed anhydrides of a successive N-protected amino acid; the N-protective group is split off and the successive N-protected amino acid is re-added to produce a tetra- or pentapeptide which is unblocked in the presence of a palladium catalyst, and the target product is separated out. The proposed peptide and a compound based on it can be used as an agent with pronounced opiate-like properties and also has anabolic properties which increase body weight as well as promoting activity in the growing zones and development of the epidermal layer including the hair. The bio-stimulating properties of the claimed peptide are also evident in the healing of wounds and repair processes.
Patent DE-69534589-T2 (DE)
Inventor: SEED BRIAN
IPC: A61K35/545
Filed: 1995-01-12
Granted: 2006-07-13
Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
Patent DE-69607332-T2 (DE)
Inventor: SHYJAN W
IPC: C12N15/12
Filed: 1996-03-29
Granted: 2000-11-30
Abstract: The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung tumors, and neoplastic conditions such as leukemias and lymphomas. Genes are identified that are differentially expressed in benign (e.g. non-malignant) tumor cells relative to malignant tumor cells exhibiting a high metastatic potential. Genes are also identified via the ability of their gene products involved in the progression to, and/or aggressiveness of, neoplastic tumor disease states. <IMAGE>
Patent DE-69622376-T2 (DE)
Inventor: WIMAN JOERGEN
IPC: B23B27/16
Filed: 1996-09-24
Granted: 2003-03-06
Abstract: A metal cutting insert is directly mounted on a support surface formed either by an insert holder, or by a shim interposed between the insert and insert holder. The insert includes a bottom surface having grooves and planar surface portions disposed between the grooves. The support surface includes ribs which fit into respective grooves of the insert. Some of the planar surface portions of the insert bear against a planar, rib-free portion of the support surface.
Patent DE-69622405-T2 (DE)
Inventor: DAVIS ROGER J
IPC: C12Q1/68
Filed: 1996-01-26
Granted: 2003-03-27
Abstract: Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
Patent DE-69626239-T2 (DE)
Inventor: HORST ROBERT W
IPC: H04L69/40
Filed: 1996-06-06
Granted: 2004-01-08
Abstract: A multiprocessor system includes a number of sub-processor systems, each substantially identically constructed, and each comprising a central processing unit (CPU), and at least one I/O device, interconnected by routing apparatus that also interconnects the sub-processor systems. A CPU of any one of the sub-processor systems may communicate, through the routing elements, with any I/O device of the system, or with any CPU of the system. Communications between I/O devices and CPUs is by packetized messages. Interrupts from I/O devices are communicated from the I/O devices to the CPUs (or from one CPU to another CPU) as message packets. CPUs and I/O devices may write to, or read from, memory of a CPU of the system. Memory protection is provided by an access validation method maintained by each CPU in which CPUs and/or I/O devices are provided with a validation to read/write memory of that CPU, without which memory access is denied. <IMAGE>   <IMAGE>
Patent DE-69629120-T2 (DE)
Inventor: EDGAR ANDREW
IPC: G06F3/0484
Filed: 1996-09-04
Granted: 2004-04-22
Abstract: A system (11) for presenting textual and/or graphical information for reading. The system includes a visual display unit (15) for displaying the textual and/or graphical information within a general layout screen, a microcomputer including processing means (13) to receive the textual and/or graphical information in an electronically encoded form and process the same for presentation on the visual display unit (15). A computer program (19) is provided for controlling the presentation of the textual and/or graphical information on the visual display unit (15) in a prescribed manner. A keyboard and mouse input (17) is included for inputting control signals to operate the processing means (13) and the computer program (19) or for altering control parameters of same. The computer program (19) sequentially locates discrete and successive portions of the textual and/or graphical information at the same position on the layout screen at a prescribed blanking time apart, each portion being displayed at this position for a prescribed display time. The general layout screen is divided into a browser pane (37) for displaying a block of textual and/or graphical information to be presented and a flash pane (39), within which the position for sequentially locating the discrete and successive portions of the textual and/or graphical information is centrally situated.
Patent DE-69632523-T2 (DE)
Inventor: BROER JAN
IPC: G02F1/13357
Filed: 1996-11-13
Granted: 2005-05-25
Abstract: The Application relates to an illumination system comprising a fluorescent lamp and a broadband, cholesteric polarizer. Such a polarizer contains a layer of a polymeric material having a cholesteric order, which material is ordered in such a way that the axis of the molecular helix extends at right angles to the layer. The broadband character of the polarizer is obtained by causing the pitch of the molecular helix to increase from a minimum value at a first surface of the cholesteric layer to a maximum value at the second surface of the layer. In accordance with the invention, the polarizer should be positioned in the illumination system in such a manner that the cholesteric layer is directed towards the fluorescent lamp with its first surface. In addition, the value of the product pmax.ne of the maximum value of the pitch in the cholesteric layer pmax and of the extraordinary refractive index ne must range between 0.61 micron and 0.76 micron. By virtue of these measures, the illumination system has a surprisingly low viewing-angle dependence of the lightness and the color. The Application further relates to a linear polarizer for use in this illumination system as well as to a display device which comprises such a linear polarizer.
Patent DE-69705113-T2 (DE)
Inventor: GUSKEY MARIE
IPC: A61Q5/12
Filed: 1997-03-18
Granted: 2002-01-31
Abstract: Disclosed are aqueous hair conditioning shampoo compositions comprising a specific surfactant component comprising an ethoxylated alkyl surfactant having from about 1 to about 8 moles of ethoxylation and an amphoteric surfactant in a shampoo with insoluble, dispersed, nonionic silicone and a select soluble cellulosic cationic organic polymer hair conditioning agent
Patent DE-69707881-T2 (DE)
Inventor: WAGNER PETER
IPC: A21D8/04
Filed: 1997-06-27
Granted: 2002-07-18
Abstract: A dough- or bread-improving composition comprising an effective amount of a deamidase such as a peptidoglutaminase, optionally in admixture with other enzymes, as well as the use of the composition in the preparation of dough and baked products.
Patent DE-69713648-T2 (DE)
Inventor: TAKAGAKI HIDETSUGU
IPC: A61K31/37
Filed: 1997-03-20
Granted: 2002-11-21
Abstract: The present invention offers a safe and effective drug for heart diseases and a safe and effective use of a benzopyran derivative for treating heart diseases such as ischemic heart disease and cardiac arrhythmia. The use of a benzopyran derivative comprises administering a pathologically effective amount of a benzopyran derivative expressed by the following general formula (I): <CHEM> wherein R<1> is an alkyl group or an alkenyl group, R<2> is a hydrogen atom, an alkyl group, an alkyl group having at least one hydroxyl group, an alkenyl group, an acyl group or a glycosyl group; or physiologically acceptable salts thereof.
Patent DE-69726460-T2 (DE)
Inventor: SUMMERS CLAYTON
IPC: G11B19/24
Filed: 1997-12-16
Granted: 2004-09-09
Abstract: An improved method and apparatus for maintaining a recording head in an optical recording system at a constant linear velocity relative to a rotatable disk support. A rotation controller uses a cumulative measure of rotation to determine an angular velocity of the rotating disk support necessary to maintain a constant linear velocity.
Patent DE-69727178-T2 (DE)
Inventor: BIRDSALL MATTHEW J
IPC: A61F2/00
Filed: 1997-08-15
Granted: 2004-11-04
Abstract: The disclosure relates to a profiled stent (20) for supporting and maintaining the patency of lumens in living tissue. The profiled stent includes a plurality of support members, each of the support members having a first side (24a), a second side (26a) positioned opposite the first side, a third side (20a) adjoining the first and second sides, a fourth side (22a) positioned opposite the third side adjoining the first and second sides. Four corners are defined by the adjoining first, second, third, and fourth sides. At least one of the support members of the stent is profiled such that the four corners of that support member are round, while the first and second sides are substantially flat or, stated differently, exhibit substantially similar radii of curvature. <IMAGE>   <IMAGE>
Patent DE-69727244-T2 (DE)
Inventor: KIRPOTIN DMITRI
IPC: A61K9/50
Filed: 1997-10-02
Granted: 2004-11-25
Abstract: The present invention comprises a material and a method of its preparation. The material may be described as hydrophilic microparticles, comprising a cluster of organic substance with a layer of polyelectrolyte on its surface. The present invention establishes an improved method for preparing aqueous colloidal dispersions of water-insoluble organic substances using polyionic hydrophilic polymers by which the stability of the suspension is maintained after removal of the stabilizing and/or solubilizing medium of the drug. This improved method can be utilized to formulate a variety of water-insoluble organic substances.
Patent DE-69731403-T2 (DE)
Inventor: LASH RAY
IPC: A61F13/49
Filed: 1997-02-28
Granted: 2006-02-09
Abstract: The present invention relates in one aspect to absorbent articles that maintain or increase fluid acquisition rates when subjected to successive fluid loads. In another aspect, the invention relates to an absorbent article useful for absorbing discharges of aqueous body fluids which has a fluid pervious topsheet, a backsheet and an absorbent core, the absorbent core including at least one upper storage component in direct fluid communication with the topsheet capable of expanding in the z-direction to form a fluid acquisition zone when contacted with aqueous body fluids, the acquisition zone being at least partially surrounded by the upper fluid storage component and beneath the fluid discharge region of the core, and a fluid acquisition/distribution component having at least a portion positioned underneath and in fluid communication with the storage component and acquisition zone.
Patent DE-69806932-T2 (DE)
Inventor: GRANGER MAURICE
IPC: A47K10/36
Filed: 1998-06-08
Granted: 2003-03-13
Abstract: A dispensing apparatus including an adjusting device which ensures constant pressure of a reel supported on a spindle. The device is associated with reel-holder arms having resilient flexibility, rails forming a slide being arranged between side wings of a housing and the reel-holder arms to allow limited sliding movement of sliders floating on the rails with elastic capacity for controlled and adapted movement to enable paper material of the reel to be maintained constantly stretched on the spindle as material is depleted from the reel.
Patent DE-69807830-T2 (DE)
Inventor: MEYER DOMINIQUE
IPC: A61K49/04
Filed: 1998-12-09
Granted: 2003-08-07
Abstract: Paramagnetic metal chelates of macrocyclic polyamino carboxylic derivatives (I) and their salts The carboxylic derivatives used to prepare the chelates are of formula (I), and their salts with bases. m = 1 or 2; R' = H, 1-4C alkyl or hydroxyalkyl, CH2-COOH, -CH2CONZ1Z2, or HOOC-CH-(CH2)m-CONHR1; Z1 and Z2 = H or 1-4C alkyl, optionally hydroxylated; R = a group of given formula (IV); a = 1 or 2; Z = a bond, CH2, CH2CONH, or (CH2)2NHCO; Z' = a bond, O, S, NQ, CH2, CO, CO-NQ, NQ-CO, NQ-CO-NQ-, or CO-NQ-CH2-CONQ; Z''' = CO-NQ, NQ-CO, CO-NQ-CH2-CONQ, or NQ-CO-CH2-NQ-CO; Q = h or 1-4C alkyl, optionally hydroxylated; R1 - R5 = H, Br, Cl, I, CO-NQ1Q2, or N(Q1)-CO-Q2; Q1 and Q2 = 2-6C alkyl, optionally hydroxylated and optionally interrupted buy O, such that Q1 and Q2 between them 4 - 10 OH groups, with the proviso that at least 1 and at most 2 of the groups R1 - R5 are amides The paramagnetic metal used to prepare the complexes is preferably gadolinium, especially Gd<3+>. Independent claim covers a scintigraphic product containing a radio-labelled chelate of (I).
Patent DE-69811039-T2 (DE)
Inventor: NIEBOER MAARTEN
IPC: C12R1/645
Filed: 1998-04-22
Granted: 2004-01-22
Abstract: The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
Patent DE-69811053-T2 (DE)
Inventor: TAMANTI MARIA LISA
IPC: G01J3/50
Filed: 1998-04-10
Granted: 2004-01-22
Abstract: The invention relates to a process for discriminating the color of a surface, comprising the steps of:     a) acquiring at least one color of a colored acquisition surface; b) comparing the color of a detecting surface with said at least one color previously acquired, so that said color can be recognized. In particular, the acquisition step a) comprises the steps of:   a1) sequentially illuminating the acquisition surface with each of three light beams corresponding to three primary colors, each of said light beams being generated by a respective emission source supplied with a supply current IR, IG, IB; a2) picking up by means of a light-receiving element the light scattered from the illuminated acquisition surface; a3) generating an electric signal VR, VG, VB proportional to the luminous intensity of the picked-up light, as the acquisition surface is being illuminated with each of the three beams and a4) controlling the supply current IR, IG, IB of the emission sources such that at least two of the electric signals VR, VG, VB generated are identical with each other within a predetermined tolerance margin.     <IMAGE>
Patent DE-69819110-T2 (DE)
Inventor: SUZUKI KUNIO
IPC: A61P3/04
Filed: 1998-11-06
Granted: 2004-07-15
Abstract: A medicament for preventive and therapeutic treatment of obesity and a disease with abnormal lipid metabolism which comprises as an active ingredient a compound selected from the group consisting of 24-alkylcholestan-3-ones and 24-alkylcholesten-3-ones such as 24-alkylcholestan-3-ones, 24-alkylcholestmonoen-3-ones, 24-alkylcholestdien-3-ones, 24-alkylcholesttrien-3-ones and 24-alkylcholesttetraen-3-ones.
Patent DE-69826291-T2 (DE)
Inventor: NOETHE AXEL
IPC: C23C14/00
Filed: 1998-06-24
Granted: 2005-02-17
Abstract: A glass sheet includes a coating comprising at least one silver layer and inner and outer antireflection layers. The glass sheet is formed by a magnetron sputtering process. The inner antireflection layer is a multiple layer comprising a layer of a titanium oxide applied by medium frequency magnetron sputtering and a layer of a metal oxide between the titanium oxide layer and a silver layer.
Patent DE-69902819-T2 (DE)
Inventor: GUERN YVES
IPC: G02B27/44
Filed: 1999-12-20
Granted: 2003-08-07
Abstract: A spectral rejection device for forming an image on an optical sensor, including a system for forming a beam of light rays coming from an observed scene, a scanning system, a system for spectrally dispersing the beam in a direction, at least one mask disposed on the path of the dispersed rays to intercept a narrow band of wavelengths, and a system for combining the dispersed rays into a beam of parallel rays focused by a lens onto an optical sensor.The invention applies in particular to the spectral analysis of a luminous flux coming from an observed scene.
Patent DE-69905459-T2 (DE)
Inventor: WEBSTER A
IPC: G21G4/08
Filed: 1999-04-20
Granted: 2004-03-11
Abstract: Palladium-103 radiochemical of high radionuclidic purity can be produced in commercial scale quantities by irradiating enriched Palladium targets comprising a mixture of Pd isotopes with protons or deuterons in the 10-50 MeV energy range. Commercially viable batch sizes with acceptable specific activity of the product Pd-103 are achieved by adjusting the irradiation energy, irradiation time, irradiation current, current density, plated target mass, plated target shape, plated target size, target isotope enrichment levels, and incident angle of the target to the beam. The method for the production of Pd-103 comprises providing a target material enriched with Pd isotopes comprising atomic masses equal to or greater than Pd-103, applying the target material onto a target support; irradiating the target material with protons or deuterons of sufficient incident energy and time to convert at least some of the Pd isotopes within the target material to Pd-103; and purifying Pd from the non-Pd components.
Patent DE-69906756-T2 (DE)
Inventor: DE ZEN VIC
IPC: E04D3/08
Filed: 1999-08-17
Granted: 2003-10-16
Abstract: A plastic shed having side walls, end walls which slope up to a central ridge line and a roof all formed of interlocking panels, the roof panels are supported at their upper ends by a ridge beam assembly comprising a metal beam extending between and supported by the end walls and a plastic sleeve encasing the metal beam, the sleeve has on each side these of below the top of the beam, integral downwardly sloping shelves on which the upper ends of the roof panels rest, the shed side walls have caps provided with upwardly sloping support platforms on which the lower ends of the roof panels rest and the shed end walls have caps provided with interlocking formations with which the roof panels interlockingly engage.
Patent DE-69908468-T2 (DE)
Inventor: GRANDVEAU GILLES
IPC: F23D14/26
Filed: 1999-03-15
Granted: 2004-04-15
Abstract: The burner consists of a head (2) made up of a base (20) with a central feed aperture (21) for the air/gas mixture, surrounded by a skirt (22) with radial outlet slits (23). The head is covered by a cap (1) and the upper edge of the skirt has a series of projecting studs (25). The studs are narrower than the distance between adjacent slits and are spaced equidistantly between them; they are located round the inner edge of the skirt.
Patent DE-69910642-T2 (DE)
Inventor: MATSUMOTO MASAKATSU
IPC: C07D493/04
Filed: 1999-03-10
Granted: 2004-06-17
Abstract: The present invention has its objects to provide a compound not only which is easy to handle, thermally stable, and high in emission efficiency, but also which can show high emission efficiency without coexisting enhancer in the system even in a protic solvent. The present invention is related to a 1,2-dioxetane derivative of general formula (I). <CHEM> Äwherein R<1>, R<2>, R<3>, R<4> and R<5> each independently represents hydrogen, alkyl or aryl; a pair of R<2> and R<3> and a pair of R<4> and R<5> may respectively be joined to each other to form a cycloalkyl group.
Patent DE-69918479-T2 (DE)
Inventor: VAN DER LELY ALEXANDER
IPC: A01J5/007
Filed: 1999-03-04
Granted: 2005-08-18
Abstract: A method of automated milking and/or treating of animals, which method comprises a number of steps for milking and/or treating the animals, such as cleaning the teats and/or foremilking and/or milking and/or stripping and/or disinfecting the teats, etc., in which there are at least two variants for at least one step and in which for the at least one step a variant is chosen at random, e.g. by means of a random generator, or periodically, said variant subsequently being carried out.
Patent DE-69920497-T2 (DE)
Inventor: BINGHAM M
IPC: A61P35/00
Filed: 1999-10-26
Granted: 2006-02-09
Abstract: The invention provides a method of inhibiting proliferation of diseased cells by contacting the diseased cells with an effective amount of a reagent that inhibits PDC specifically in said diseased cells.
Patent DE-69929205-T2 (DE)
Inventor: CAPPEL E
IPC: B65D33/06
Filed: 1999-07-01
Granted: 2006-07-13
Abstract: A plastic bag comprises opposing body panels (12, 14) fixedly connected to each other along a pair of sides and a bottom bridging the pair of sides. A reclosable zipper (32) extending along a mouth portion formed opposite the sealed bottom of the plastic bag. The zipper is preferably free of graspable upper pull flanges in order to best accommodate a slider (32) and inhibit operation of the zipper without the slider (32). The slider (32) is mounted to the zipper for movement between a closed position and an open position. The zipper is closed while the slider is in the closed position. The zipper is opened in response to movement of the slider to the open position. To inhibit tampering with the contents of the bag, the bag includes a tamper-evident feature (40). In one set of embodiments, the tamper-evident feature (40) initially maintains the slider in the closed position and allows the slider to move away from the closed position toward the open position in response to removing or breaking the tamper-evident feature. In another set of embodiments, the tamper-evident feature initially maintains a mouth portion of the plastic bag in a folded position and allows the mouth portion to be unfolded in response to removing or breaking the tamper-evident feature.