baber/WOPTO huggingface dataset:
Patent CA-3101639-A1 (CA)
Inventor: BRUNEAU FRANCOIS-XAVIER
IPC: B60C9/28
Filed: 2019-05-22
Abstract: The invention relates to a pneumatic tire comprising a crown having at least one layer of reinforcing elements. The radially outermost layer includes at least one wave (512). The waves (512) of the radially outermost layer (5) are such that, for each meridian, radially inward from the center of the bottom surface (243) of the closest main groove (24), the points of the waves lie radially outside the points of said layer (5) by at least a radial distance of 1.5 mm. The waves (512) of the radially outermost crown layer constitute at least 10% of the radially outer surface (SRE) of said crown layer (5). A rubber compound having a maximum dynamic shear modulus G *, measured at 40°C at 10% peak-to-peak deformation at 10 Hz, of 3.25 MPa, constitutes at least 30% of the rubber compounds lying on top of said waves.
Patent CA-3102265-A1 (CA)
Inventor: FABBRI NICOLA
IPC: A61B17/58
Filed: 2019-06-03
Abstract: Described herein is an intramedullary femoral nail implant. The implant can be more easily converted to a load bearing hip replacement. Fixation of the intramedullary nail may be enhanced by injection of cement. Disclosed devices may be preferable to other types of intramedullary nails at the time of the first procedure given their characteristics of improved fixation, stability, and flexibility for potential conversion via a less complex operation.
Patent CA-3105265-A1 (CA)
Title: Novel carrier particles for dry powder formulations for inhalation
Inventor: GUIDI TOMASO
IPC: A61K9/16
Filed: 2019-07-24
Abstract: The present invention concerns carrier particles suitable for use in dry powder formulations for inhalation. The invention also relates to processes for their preparation by spray-congealing.
Patent CA-3105381-A1 (CA)
Inventor: BEI FENGFENG
IPC: C12N15/864
Filed: 2019-07-11
Abstract: The present invention is based on the development of artificial targeting sequences that enhance permeation of agents into cells and across the blood brain barrier, compositions comprising the sequences, and methods of use thereof. Provided herein is an AAV comprising a capsid protein comprising a targeting sequence and a transgene, preferably a therapeutic or diagnostic transgene. Further, provided herein are methods of delivering a transgene to a cell, the method comprising contacting the cell with an AAV or fusion protein described herein.
Patent CA-3106622-A1 (CA)
Title: Allosteric modulators of the mu opioid receptor
Inventor: AUSTIN JOEL FRANCIS
IPC: A61P25/04
Filed: 2018-11-19
Abstract: Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.
Patent CA-3107664-A1 (CA)
Title: Aerosol generation
Inventor: KABIRAT JUNIOR
IPC: A24F40/30
Filed: 2019-07-31
Abstract: A laminate aerosol generating material, wherein the material comprises an aerosol- forming layer (2) attached to a carrier layer (4), wherein the aerosol- forming layer (2) comprises an amorphous solid and wherein the carrier (4) comprises wood and/or cardboard.
Patent CA-3108484-A1 (CA)
Inventor: CAMPBELL ANTHONY STEWART
IPC: A61P25/14
Filed: 2018-08-06
Abstract: The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.
Patent CA-3108812-A1 (CA)
Title: Utilisation d'un anticorps tim-3 dans la preparation de medicaments pour le traitement de tumeurs
Inventor: SUN XING
IPC: A61K39/395
Filed: 2019-08-20
Abstract: L'invention concerne l'utilisation d'un anticorps TIM-3 dans la préparation de médicaments pour le traitement de tumeurs. Spécifiquement, l'invention concerne l'utilisation de l'anticorps TIM-3 ou d'un fragment de liaison à l'antigène de celui-ci dans la préparation de médicaments pour le traitement du cancer du poumon non à petites cellules, l'anticorps TIM-3 contenant une région variable de chaîne lourde représentée dans la SEQ ID NO : 33 et une région variable de chaîne légère représentée dans la SEQ ID NO : 36. En outre, l'invention concerne également l'utilisation de l'anticorps TIM-3 ou du fragment de liaison à l'antigène de celui-ci et d'un anticorps PD-1 ou d'un fragment de liaison à l'antigène de celui-ci dans la préparation conjointe de médicaments pour le traitement de tumeurs.
Patent CA-3108928-A1 (CA)
Inventor: DUFRANE DENIS
IPC: C12M1/00
Filed: 2018-08-23
Abstract: The invention concerns an automated method for treating a biological tissue in order to produce a tissue matrix for allograft or xenograft, wherein the following sequence of steps: a) introducing said tissue into a treatment solution, b) treating the tissue in the solution, while stirring, c) removing the tissue from the treatment solution and d) emptying the reactor vessel, is repeated until the end of the treatment, and wherein all of the steps of all of the sequences are implemented automatically in a "classified" enclosure and inside a single reactor vessel, by changing the treatment solution in the reactor vessel between two sequences. The reactor vessel comprises a container designed to contain a biological tissue treatment solution into which a removable biological tissue receiver and stirring means are introduced.
Patent CA-3109062-A1 (CA)
Inventor: PAYNE STEPHEN THOMAS
IPC: C12N1/21
Filed: 2019-08-29
Abstract: The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.
Patent CA-3109408-A1 (CA)
Title: Universal gasket
Inventor: BROWN GLEN W
IPC: E03D11/13
Filed: 2021-02-16
Abstract: A universal gasket includes a top surface having an outer diameter and an inner diameter and a bottom surface having an outer diameter and an inner diameter.  A  sidewall couples the top surface to the bottom surface, with a chamfer providing a decrease in diameter between the top surface and the bottom surface. The universal gasket is disposed between a water tank and a toilet bowl, providing a connection and seal between the water tank and a throat opening in the toilet bowl.
Patent CA-3117406-A1 (CA)
Title: Collapsible dunnage box
Inventor: MCDADE CLINTON LAWRENCE
IPC: B65D85/30
Filed: 2020-04-09
Abstract: A collapsible dunnage box is provided that includes a box base and first and second opposed base sidewalls attached to the box base on opposing sides of the box. First and second opposed top sidewalls are pivotally attached to the top edge of respective ones of the base sidewalls. First and second opposed top endwalls are provided to form a box enclosure. The base endwalls are pivotally-mounted to the top endwalls and are moveable between a lowered, vertical deployed position enclosing respective ends of the box and a raised, horizontal stowed position to contain and store dunnage positioned in an upper portion of the box.
Patent CA-3118822-A1 (CA)
Inventor: DAS KAMAL K
IPC: A61F2/16
Filed: 2019-04-05
Abstract: An exemplary ophthalmic lens includes an optic comprising an anterior optic surface and a posterior optic, and a multi-curvature optical edge surrounding the optic and connecting the anterior optic surface to the posterior optic surface, the multi-curvature optical edge comprising a plurality of tangentially-connected curved surfaces configured to mitigate positive dysphotopsia by directing or diffusing from light incident on the multi-curvature optical edge away from a fovea of a patient.
Patent CA-3119446-A1 (CA)
Inventor: GRECI STEPHEN
IPC: E21B43/04
Filed: 2018-12-18
Abstract: Les modes de réalisation de l'invention comprennent des ensembles massifs de gravier, un procédé de dérivation d'un réducteur de fluide pendant des opérations de gravillonnage et des procédés de régulation de l'écoulement de fluide pendant et après des opérations de gravillonnage. Dans un mode de réalisation, l'invention concerne un ensemble massif de gravier comprenant un réducteur de débit qui est accouplé à une rame de fond de puits qui est déployée dans un trou de forage. Le réducteur de débit forme un premier passage de fluide depuis le trou de forage jusqu'à une cavité interne de la rame. L'ensemble massif de gravier comprend une partie de dérivation de fluide ayant une première chambre, un élément d'étanchéité inséré dans la première chambre ; et un ensemble d'actionnement utilisable pour actionner l'élément d'étanchéité. La partie de dérivation de fluide forme un second passage de fluide depuis le trou de forage jusqu'à la cavité interne de la rame de fond de puits avant l'actionnement de l'ensemble d'actionnement. Après l'actionnement de l'ensemble d'actionnement, un écoulement de fluide dans le second passage de fluide est limité par l'élément d'étanchéité.
Patent CA-3119506-A1 (CA)
Title: New heterocyclic compounds
Inventor: KUHN BERND
IPC: A61K31/5365
Filed: 2019-11-20
Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Patent CA-3120510-A1 (CA)
Inventor: SIPPLE DANIEL
IPC: A61B1/07
Filed: 2019-11-15
Abstract: L'invention concerne un système de détection de biomarqueurs comprenant un biomarqueur cible et un système de distribution fluidique possédant un dispositif d'administration comprenant une extrémité distale. Le système de distribution fluidique est en contact avec le biomarqueur cible. Le dispositif d'administration comprend une lumière et un canal fluidique. Le système de détection de biomarqueur de l'invention comprend en outre un matériau luminescent de biomarqueur en contact avec l'extrémité distale du dispositif d'administration. Le système comprend également un système optique en communication optique avec le matériau luminescent de biomarqueur, le système optique comprenant un récepteur optique et un détecteur.
Patent CA-3120802-A1 (CA)
Title: Novel fish totivirus
Inventor: NYLUND STIAN
IPC: C12N7/00
Filed: 2020-02-04
Abstract: The invention relates to a novel fish virus, indicated to be a Totivirus, which causes mortality in fish, and to methods of detecting said virus in fish, and related uses.
Patent CA-3122817-A1 (CA)
Title: Tonneau cover system with insert for supporting cross-bow members
Inventor: COHOON WILLIAM ROY
IPC: B60P7/02
Filed: 2021-06-18
Abstract: A frame rail assembly for supporting a tonneau cover for a vehicle cargo area, and an associated tonneau cover system are provided. The frame rail assembly includes at least one frame rail locatable on the cargo area. The frame rail has one or more slots formed therein, and inserts that fit within the slots. The inserts include a sealing portion engageable with the tonneau cover. The sealing portion includes an insert fastening member, which is engageable with a complementary fastening member located on an edge of the tonneau cover. The inserts support one or more cross-bow members extending from the frame rail and over the cargo area. The frame rail assembly may be particularly beneficial in preventing water and/or debris intrusion into a cargo area while supporting a low-profile tonneau cover. The sealing portion of the inserts supports such a benefit.
Patent CA-3123583-A1 (CA)
Inventor: HUANG MINGJUN
IPC: A61P37/02
Filed: 2019-12-17
Abstract: Les dosages et méthodes selon l'invention permettent d'obtenir des caractéristiques pharmacocinétiques (PK) et pharmacodynamiques (PD) souhaitables qui inhibent l'activité du complément par la voie alterne, par exemple au moins 85 % ou davantage d'inhibition de l'activité de la voie alterne (AP) in vivo, à des dosages d'environ 120 mg à 200 mg de BID qui fournissent un niveau de plasma Cà d'au moins environ 65 ng/ml, ce qui permet d'obtenir une inhibition de la voie alterne suffisante pour réduire le risque d'exacerbation du complément. En outre, la forme galénique selon l'invention fournit un maximum Cmax significativement faible, ce qui permet d'obtenir une marge de sécurité supplémentaire et une meilleure flexibilité de dosage.
Patent CA-3124209-A1 (CA)
Inventor: FAUVET DAMIEN
IPC: F23R3/00
Filed: 2019-12-17
Abstract: The invention discloses a turbomachine combustion chamber, comprising two coaxial walls (30, 31) of revolution extending one inside the other and delimiting between one another an annular air-circulation space (33), and an exterior wall (32), and at least one injector (35) passing through said walls (30 to 32) via apertures, characterized in that the injector comprises a peripheral tube connected to said walls (30 to 32) by three connections, at least two connections being of the slideway and/or ball-joint or bellows type.
Patent CA-3127841-A1 (CA)
Inventor: BRANTHOVER LEWIS PEARCE
IPC: A61B17/15
Filed: 2020-02-21
Abstract: L'invention concerne un guide de coupe comprenant une première face et une seconde face opposée. Le guide de coupe comprend en outre une première ouverture et une seconde ouverture s'étendant à travers le guide de coupe de la première face à la seconde face. Les première et seconde ouvertures sont conçues pour guider un outil chirurgical dans la découpe d'un os. Le guide de coupe comprend en outre un premier trou s'étendant à travers le guide de coupe de la première face à la seconde face. Le guide de coupe comprend en outre un second trou s'étendant à travers le guide de coupe. Un axe central du second trou est orienté selon un angle aigu par rapport à la seconde face. Les premier et second trous sont conçus pour recevoir un fil pour positionner le guide contre l'os.
Patent CA-3130032-A1 (CA)
Title: A long-acting g-csf for preventing neutropenia or reducing duration of neutropenia
Inventor: ERTAN-AHMED SENEM
IPC: A61P7/00
Filed: 2020-01-21
Abstract: CA 03130032 2021-08-12 ABSTRACT A hybrid Fc fusion G-CSF for use in preventing neutropenia or reducing the duration of neutropenia in a patient by administering therapeutically effective amount of a human hybrid (hy) Fc fused granulocyte colony stimulating factor (G-CSF) developed as next-generation G-CSF. Date Recue/Date Received 2021-08-12
Patent CA-3130277-A1 (CA)
Inventor: ARENAS DANYEL ARMANDO
IPC: A61K33/20
Filed: 2020-02-20
Abstract: L'invention concerne des compositions de solution intraveineuse comprenant de l'acide hypochloreux (HOCl) appropriées pour le traitement systémique ou la prévention de diverses infections.
Patent CA-3130556-A1 (CA)
Title: Temperature control circuitry for an aerosol delivery device
Inventor: Sur Rajesh
IPC: G05D23/24
Filed: 2020-02-26
Abstract: An aerosol delivery device is provided. The aerosol delivery device includes a power source, a heating element having a resistance that is variable and proportional to a temperature of the heating element, and a power switch coupled to and between the power source and the heating element. The aerosol delivery device also includes processing circuitry and a low-side current-sensing circuit coupled to and between the heating element and the processing circuitry. The low-side current-sensing circuit produces an output voltage that is equal or proportional to an output heater voltage at the heating element. The processing circuitry measures the output voltage, determines the resistance of the heating element, determines the temperature of the heating element from the resistance, and adjusts a signal to the power switch when the temperature deviates from a predetermined set point.
Patent CA-3131484-A1 (CA)
Title: Uv light monitoring system for a uv decontamination apparatus
Inventor: KARITONAS TAUTVYDAS
IPC: A61L2/10
Filed: 2021-09-21
Abstract: The invention provides a UV light monitoring system that is capable of estimating the UV  irradiance on a target surface oriented at an arbitrary angle relative to a UV  emitter that emits UV  light. The UV light monitoring system can be used in a system or process for disinfecting a space, where the UV light monitoring system may enable a dose of UV light experienced by a surface in the space to be accurately estimated. The invention can alternatively or additionally provide a mechanism for determining the orientation of a UV light monitor to assist with the optimal placement of the UV light monitor within a space. The orientation is determined based on a comparison between signals received from first and second solar cells that are located on different faces of the UV light monitor.
Patent CA-3134825-A1 (CA)
Inventor: BURROWS FRANCIS
IPC: A61P35/00
Filed: 2020-03-27
Abstract: The present invention relates to the field of cancer therapy. Specifically, provided are methods of treating Squamous Cell Carcinoma in a subject with a farnesyltransferase inhibitor (FTI) that include determining whether the subject is likely to be responsive to the FTI treatment based on the expression level of H-Ras.
Patent CA-3135366-A1 (CA)
Inventor: DASKALAKIS KONSTANTINOS
IPC: H05B45/60
Filed: 2020-04-02
Abstract: The present invention relates to a white organic light emitting device (WOLED) comprising an electroluminescent material (ELM) and a Bragg converter disposed adjacent to the ELM. In addition, the invention also relates to a method for producing white light using said WOLED, use of the WOLED for producing white light, and a process for producing said WOLED.
Patent CA-3135929-A1 (CA)
Title: Compose amine aromatique et son utilisation dans la preparation d'inhibiteurs et de regulateurs doubles d'ar et de brd4
Inventor: DU WU
IPC: A61K31/501
Filed: 2020-03-31
Abstract: L'invention concerne un composé amine aromatique et son utilisation dans la préparation d'inhibiteurs et de régulateurs doubles d'AR et de BRD4. Plus particulièrement, l'invention concerne un composé représenté par la formule I, ledit composé ayant des effets inhibiteurs doubles sur AR et BRD4. Le composé est non seulement capable d'inhiber la prolifération de lignées cellulaires du cancer de la prostate à expression multiple du récepteur des androgènes AR (LNCAP/AR), mais présente également de bons effets inhibiteurs sur des lignées du cancer de la prostate VCaP et RRRV1 qui sont résistants aux médicaments contre le cancer de la prostate (enzalutamide) sur le marché. Le composé est lui-même un composé capable d'identifier simultanément des cibles doubles d'AR et de BRD4 et peut être utilisé en tant qu'inhibiteur double d'AR/BRD4, et peut également être utilisé pour préparer des chimères ciblant la protéolyse (PROTAC) pour induire la dégradation de cibles doubles AR/BRD4, et a de bonnes perspectives pour une application dans la préparation de médicaments pour le traitement de maladies associées à AR et BRD4.
Patent CA-3139668-A1 (CA)
Inventor: BUSHBY BRAYTON
IPC: A47J43/04
Filed: 2020-04-16
Abstract: L'invention concerne un dispositif shaker qui peut comprendre un bouchon configuré pour s'adapter de manière élastique autour d'au moins une partie d'un récipient pour fermer une ouverture du récipient et pour mettre en prise le bouchon avec le récipient pour maintenir le bouchon sur le récipient. Le dispositif shaker peut comprendre une tige de mélange fixée au bouchon et configurée pour être suspendue dans le récipient lorsque le bouchon ferme l'ouverture du récipient.
Patent CA-3142392-A1 (CA)
Title: Device and system for single photon detection using a plurality of superconducting detection means connected in parallel
Inventor: PERRENOUD MATTHIEU
IPC: G01J5/20
Filed: 2020-06-16
Abstract: The present invention concerns a for single photon detection comprising at least two superconducting detection means (1) as well as a bias current source (2), a filter element (3) and a readout circuit (4), wherein each superconducting detection means (1) forms a detection area adapted for absorption of incident photons and is connected in parallel, each superconducting detection means (1) being maintained at a temperature below its critical temperature (TC) and provided with an electrical bias current (IB) situated close to and below its critical current (IC) such as to normally be maintained in a non-resistive superconducting state, and being adapted to transition, at photon absorption, from said non-resistive superconducting state to a resistive state due to an increase in current density within the superconducting detection means (1) above the critical current (IC), said readout circuit (4) being adapted to sense a voltage change corresponding to said transition of the superconducting detection means (1) into its resistive state, such as to allow to create an event signal for each absorption of an incident photon by any of said superconducting detection means (1). The device distinguishes itself by the fact that it further comprises at least one current re-distribution means (5) adapted for at least partly redistributing current arising after absorption of incident photons by any of said superconducting detection means (1) into said current re-distribution means (5), such as to avoid any of the superconducting detection means (1) not having absorbed an incident photon of suffering an increase in current density above its critical current (IC). The present invention also concerns a system for single photon detection comprising at least two such devices.
Patent CA-3144838-A1 (CA)
Title: Actuation system
Inventor: BREWER PAUL
IPC: B64C13/50
Filed: 2022-01-05
Abstract: An actuation system, for example an actuation system for an aircraft control surface (8), is provided. The actuation system may include a rotary driver (80) and three or more actuator modules (16), and each actuator module may be connected to the rotary driver such that the three or more actuator modules are configured to drive rotation of the rotary driver in combination.
Patent CA-3144954-A1 (CA)
Title: Electrical impulse earth-boring tools and related systems and methods
Inventor: LEHR JOERG
IPC: E21B47/12
Filed: 2020-07-08
Abstract: The downhole tool may include an electrical power source, a positive and a negative electrode, and at least one sensor. The positive and negative electrodes may be configured to generate an electric field between the positive and the negative electrode with an electrical charge from the electrical power source and discharge the electric charge through a downhole formation. The at least one sensor may be configured to detect quantum particles dislocated by at least one of the electric field and the discharged electrical charge to determine downhole information from at least one of a travel time of the quantum particles, a composition of the quantum particles, a quantity of the quantum particles, and a charge of the quantum particles.
Patent CA-3151116-A1 (CA)
Inventor: LIU HSHIOU-TING
IPC: A61K31/551
Filed: 2020-08-14
Abstract: La présente invention concerne des formes cristallines du (5-méthyl-pyrazin-2-ylméthyl)-amide de l'acide 2-(4-méthyl-[1,4]diazépan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza-benzo[c]fluorène-6-carboxylique (Composé I). La présente invention concerne en outre des compositions contenant les formes cristallines et une utilisation thérapeutique des formes cristallines et des compositions associées.