Patent SG-11201900634V-A (SG)
Title: Chimeric antigen receptor
Inventor: CONNOLLY John Edward
IPC: C12N5/0783
Filed: 2017-07-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIPO I PCT °Ens °nolo omm Oil mo 0II1111111 ow (10) International Publication Number WO 2018/019772 Al (51) International Patent Classification: A61K 39/00 (2006.01) Cl 2N 5/0783 (2010.01) C07K 16/30 (2006.01) (21) International Application Number: PCT/EP2017/068654 (22) International Filing Date: 24 July 2017 (24.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/366,729 26 July 2016 (26.07.2016) US 62/366,731 26 July 2016 (26.07.2016) US (71) Applicant: TESSA THERAPEUTICS PTE. LTD. [SG/SG]; 8 Temasek Boulevard #24-02, Suntec Tower Three, Singapore 038988 (SG). (71) Applicant (for LS only): RICHARD IAN CLEGG [GB/GB]; City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (72) Inventors: CONNOLLY, John Edward; c/o Tessa Ther- apeutics Pte. Ltd., 8 Temasek Boulevard #24-02, Suntec Tower Three, Singapore 038988 (SG). VU, Dang L.; c/o Tessa Therapeutics Pte. Ltd., 8 Temasek Boulevard #24-02, Suntec Tower Three, Singapore 038988 (SG). (74) Agent: CLEGG, Richard et al.; Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: CHIMERIC ANTIGEN RECEPTOR (57) : Chimeric Antigen Receptors (CARs) comprising a costimulatory sequence which is, or which is derived from, the intracellular domain of CD226, or a fragment thereof, are disclosed. Also disclosed are compositions comprising such CARs, and uses and methods using the same. Figure 'IA W O 20 18/0 1977 2 Al Figure 113 [Continued on next page] WO 2018/019772 Al IMEDIMOM0101011MERIONIMOHMOHOMOIREM TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))