baber/WOPTO huggingface dataset:
Patent WO-2019050924-A1 (WO)
Title: Combination therapy for treating cancer
Inventor: RAIMONDI MARIA ALEJANDRA
IPC: A61K31/5377
Filed: 2018-09-05
Abstract: The disclosure relates to methods, compounds for use and medicaments for the treatment of cancer comprising administering to a subject in need thereof a first agent in a therapeutically effective amount and one or more second agents each in a therapeutically effective amount. In some embodiments, the first agent comprises an EZH2 inhibitor. In certain embodiments, the first agent is tazemetostat or a pharmaceutically acceptable salt thereof and the methods of the disclosure are used to treat lung cancer, e.g., non-small cell lung cancer.
Patent WO-2019094104-A1 (WO)
Title: Sommier de matelas ajustable divisé pour de multiples utilisateurs
Inventor: KRAMER KENNETH L
IPC: A47C19/02
Filed: 2018-09-14
Abstract: Des ensembles matelas ajustables et des processus intégrant un sommier de matelas ajustable dimensionné de manière à supporter un matelas conçu pour, en cours d'utilisation, recevoir deux utilisateurs couchés sur le dos comprennent un cadre de sommier pourvu d'un premier sommier inférieur conçu avec au moins un actionneur motorisé permettant l'inclinaison ou la déclinaison de la surface de support du matelas et d'un second sommier inférieur dépourvu d'actionneur motorisé et en butée. Le second sommier est couplé mécaniquement au premier de telle sorte qu'une articulation du premier sommier inférieur entraîne une articulation similaire dans le second sommier. Les premier et second sommiers ont des dimensions de longueur, hauteur et largeur similaires qui, collectivement, se rapprochent de la taille du matelas surdimensionné conçu pour recevoir deux utilisateurs couchés sur le dos, par exemple la taille King, la taille Queen, la taille California King ou autre.
Patent WO-2019067702-A1 (WO)
Title: Small molecule inhibitors of galectin-3
Inventor: JALAGAM PRASADA RAO
IPC: C07D403/14
Filed: 2018-09-27
Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
Patent WO-2019083842-A1 (WO)
Inventor: KYRIAKIDES THEMIS
IPC: A61L27/36
Filed: 2018-10-19
Abstract: La présente invention concerne des compositions et des méthodes pour traiter une plaie, ou un emplacement d'intérêt, chez un mammifère par l'administration d'une matrice extracellulaire décellularisée (ECM) dépourvue de thrombospondine-2 (TSP-2-nul ECM). L'invention concerne une composition acellulaire comprenant une ECM décellularisée TSP-2-nul. Dans un autre mode de réalisation, l'invention concerne un hydrogel ajustable comprenant une ECM décellularisée TSP-2-nul. L'invention concerne également des méthodes pour accélérer la migration cellulaire, des méthodes pour améliorer l'invasion cellulaire, des méthodes pour améliorer la croissance et la maturation vasculaire d'une région à traiter, et/ou des méthodes pour améliorer une réparation de plaie chez un mammifère en ayant besoin.
Patent WO-2019079809-A1 (WO)
Title: Biomimetic platforms to model vascular pathophysiology, diagnostics, and therapy
Inventor: ROMER LEWIS
IPC: A61L31/12
Filed: 2018-10-22
Abstract: In one aspect, provided is a composition (biomimetic composition) that includes a biomimetic in vitro model of an arteriolar vessel comprising: at least one of 1) human smooth muscle cells and 2) human pulmonary endothelial cells; wherein the vessel recapitulates one or more of the overall tubular geometry, morphometries, extracellular matrix constituents, cellular morphology, cellular alignment, and functional heterotypic connections between the human smooth muscle cells and/or the human endothelial cells as compared to an in vivo arteriolar vessel. A microfluidics-based model platform of the pulmonary circulation is provided. Methods of use include measuring flow in biomimetic vessels, and to determine the resistance of these biomimetic vessels in the setting of a variety of experimental conditions that recapitulate the pathobiology of pulmonary hypertension.
Patent WO-2019099671-A1 (WO)
Title: Méthodes et compositions pour l'amélioration de la fonction lysosomale et le traitement d'une maladie neurodégénérative
Inventor: DUGAN LAURA LEE
IPC: A61P39/06
Filed: 2018-11-15
Abstract: L'invention concerne des méthodes de réduction de la déficience en lysosomes dépendant de l'âge et/ou de traitement d'une maladie neurodégénérative liée à l'âge, d'une maladie fibrotique ou d'une maladie rhumatologique chez un patient, consistant à administrer au patient un agent thérapeutique. L'agent thérapeutique inhibe la nicotinamide adénine dinucléotide phosphate (NADPH)-oxydase (NOX) ou un effecteur de NOX en aval.
Patent WO-2019148141-A1 (WO)
Title: Methods for analyzing genetic data to classify multifactorial traits including complex medical disorders
Inventor: ZHOU JIAN
IPC: G06F19/24
Filed: 2019-01-28
Abstract: Processes to identify variants that affect biochemical regulation are described. Generally, models are used to identify variants that affect biochemical regulation, which can be used in several downstream applications. A pathogenicity of identified variants is also determined in some instances, which can also be used in several. Various methods further develop research tools, perform diagnostics, and treat individuals based on identified variants.
Patent WO-2019157108-A1 (WO)
Title: Furniture frame
Inventor: PATHIRATNE SEAN
IPC: A47B91/02
Filed: 2019-02-06
Abstract: A furniture frame is provided that includes a plurality of frame members and a socket coupled to at least one of the plurality of frame members. The socket may include a plurality of walls arranged about a central axis and enclosing the central axis. The frame may further include a leg configured to be removably inserted into the socket. A first portion of the leg that is configured to be inserted into the socket may include walls having approximately a first thickness, and a second portion of the leg that is not configured to be inserted into the socket may include walls having approximately a second thickness that is twice as large as the first thickness. The frame members, socket, and leg may comprise metal.
Patent WO-2019161129-A1 (WO)
Title: Rescuing cancer patients from resistance to treatment with inhibitors of pd-1/pd-l1 interactions
Inventor: DONG HAIDONG
IPC: A61K45/06
Filed: 2019-02-14
Abstract: Materials and methods for inhibiting sPD-L1 production to prevent downregulation of the immune system and enhance the use of inhibitors of PD-1/PD-L1 interaction are provided herein. The materials and methods can be used in the treatment of cancer, for example.
Patent WO-2019183574-A1 (WO)
Inventor: MATTHEWS MANYALIBO JOSEPH
IPC: B22F3/105
Filed: 2019-03-22
Abstract: A nanofluid laser entrainment additive manufacturing apparatus, system and method including a substrate, a dilute nanofluid of inert gas suspended nanoparticles on the substrate, a focused energy beam that irradiates the nanoparticles to selectively melt the nanoparticles, and a raster system that raster scans the focused energy beam across the inert gas suspended nanoparticles to create predetermined shapes by additive manufacturing.
Patent WO-2019191103-A1 (WO)
Inventor: ARMSTRONG ROY
IPC: G01N21/49
Filed: 2019-03-26
Abstract: A portable remote sensing system for real-time assessments of total suspended solids (TSS) in surface waters using above-water hyperspectral measurements. The system combines a miniature high signal-to-noise ratio spectrometer coupled to a credit card-size computer, lens, rechargeable battery, GPS, display panel, and dedicated software to derive TSS from above-water spectral measurements.
Patent WO-2019209494-A1 (WO)
Title: Visualizing last/next known data values in time travel traces
Inventor: MOLA JORDI
IPC: G06F11/36
Filed: 2019-04-06
Abstract: Presenting historical state of a code element of a prior execution of an entity. An embodiment includes presenting historical state of the code element based on replaying segment(s) of the prior execution from trace data. Presenting the historical state includes presenting a first state of the code element, in connection with a first execution time point. The first state is based on a first memory access for the code element at the first execution time point. Presenting the historical state also includes presenting the first state of the code element along with an indication that the first state is a last known state (in connection with a subsequent execution time point) or a next known state (in connection with a prior execution time point).
Patent WO-2019199703-A1 (WO)
Inventor: FOLAN MARTYN G
IPC: A61F2/97
Filed: 2019-04-08
Abstract: Un dispositif de pose d'endoprothèse ayant une configuration d'administration pour administrer une endoprothèse à un emplacement de traitement et une configuration de déploiement pour déployer l'endoprothèse au niveau de l'emplacement de traitement peut comprendre une gaine externe, une tige interne disposée de façon coulissante à l'intérieur d'une lumière de la gaine externe, et un élément de pointe distale attaché de manière fixe à une extrémité distale de la tige interne. Une partie distale de la gaine externe peut comprendre une pluralité de bandes longitudinales disposées de manière circonférentielle autour de la lumière de la gaine externe. Au moins une partie de l'élément de pointe distale peut être configurée pour coulisser sur une extrémité distale de la gaine externe dans la configuration d'administration.
Patent WO-2019212922-A1 (WO)
Title: Systems and methods of spectrophotometry for the determination of genome content, capsid content and full/empty ratios of adeno-associated virus particles
Inventor: WU ZHUCHUN
IPC: G01N30/88
Filed: 2019-04-27
Abstract: The present disclosure relates to using spectrophotometry to estimate genome copies and full/empty ratios adeno-associated virus particles.
Patent WO-2019213075-A1 (WO)
Title: Methods, systems, and apparatus for encapsulating a sequestration medium
Inventor: PARK AH-HYUNG
IPC: B01J19/00
Filed: 2019-04-30
Abstract: An apparatus for encapsulating a material includes a first channel in fluid communication with a source of a material for encapsulation, at least one second channel in fluid communication with a source of a photopolymerizable compound, and at least one third channel in fluid communication with a source of an encapsulating fluid. Flow of the photopolymerizable compound into the first channel produces sheath flow in the first channel such that the material is within the polymerizable compound. Addition of the encapsulating fluid produces encapsulation precursors. Upon irradiation via a UV- radiation source, the photopolymerizable compound in the encapsulation precursor forms a polymer shell encapsulating the material for encapsulation. Materials such as nanoparticle organic hybrid materials (NOHMs) and a metal-organic frameworks (MOFs) can be thus encapsulated as carbon sequestration micro particles, as the polymer shell is permeable by gases such as carbon dioxide but selectively rejects other compounds such as water.
Patent WO-2019217971-A1 (WO)
Title: Seamless smart munitions system and method
Inventor: PETERSON DAVID
IPC: G01S5/02
Filed: 2019-05-13
Abstract: Systems and methods for deploying smart munitions may provide targeting metadata generated by surveillance networks to munitions deployment and guidance systems for smart munitions. Targeting metadata may be received by a conduit system and automatically processed to generate guidance and deployment data actionable by a munitions deployment platform.
Patent WO-2019222280-A1 (WO)
Title: Task ambient hvac system for distributed space conditioning
Inventor: BENEFIELD DOUGLAS
IPC: G05D23/00
Filed: 2019-05-14
Abstract: Embodiments of the present disclosure enable an HVAC system comprising an adaptive air distribution system, and methods for distributed and adaptive control of an occupant comfort parameter in a localized, distributed space, within a multizone environment. The system comprises an HVAC system controller, sensors, and actuators for the control and distribution of a primary airflow of an HVAC system into a specific zone of a residential or housing unit. The various system elements are configured to adapt operation under a variable sensible or latent internal load gain or change to achieve a desired occupant comfort parameter target set point or occupant ambient target for a distributed zone within a multizone environment. The occupant comfort parameter target set point is configurable through a task ambient management system residing within an application cloud server operably engaged with an application database, the application cloud server being communicably connected to the HVAC system controller.
Patent WO-2019245692-A1 (WO)
Inventor: COBAN MUHAMMED ZEYD
IPC: H04N19/124
Filed: 2019-05-21
Abstract: An example device includes processing circuitry configured to determine a first state of a data structure, the first state representing a first quantizer applied to a previously quantized or inverse quantized value of a previous transform coefficient of residual data for a block of the video data and update the data structure to a second state according to the first state and a parity of a partial set of syntax elements representing a partial set of a plurality of coefficient levels for the previous transform coefficient. The processing circuitry is further configured to determine a second quantizer to be used to quantize or inverse quantize a current value of a current transform coefficient according to the second state of the data structure and quantize or inverse quantize the current value of the current transform coefficient using the second quantizer.
Patent WO-2019241170-A1 (WO)
Title: System and method of managing access of a user's health information stored over a health care network
Inventor: MCFARLANE CHRISSA TANELIA
IPC: G16H10/60
Filed: 2019-06-10
Abstract: A system and a method for managing access of a user's health information stored over a health care network are disclosed. The method includes providing a Health Information Exchange (HIE) server implemented over a blockchain network. The HIE server stores users' health information. Further, a user device may be present in communication with the HIE server. An access of the user's health information may be provided to a provider based on access rights assigned for the provider, in a smart contract set by a user, and a monetary value set for the access rights may be received.
Patent WO-2020005559-A1 (WO)
Inventor: XU CHENG
IPC: H01G4/30
Filed: 2019-06-13
Abstract: L'invention concerne, selon des de modes de réalisation, un condensateur à film mince incorporé et un inducteur magnétique qui sont assemblés dans deux couches d'accumulation adjacentes d'un substrat de boîtier de semi-conducteur. Le condensateur à film mince est placé sur la surface d'une première des couches d'accumulation et l'inducteur magnétique est partiellement disposé dans un creux dans la couche d'accumulation adjacente. Le condensateur à film mince incorporé et l'inducteur magnétique intégré sont configurés à l'intérieur d'une ombre de puce qui est sur un côté de puce du substrat de boîtier de semi-conducteur.
Patent WO-2020009836-A1 (WO)
Title: Asymmetric ion-exchange methods of making strengthened articles with asymmetric surfaces
Inventor: HOU JUN
IPC: C03C21/00
Filed: 2019-06-25
Abstract: A method of making strengthened articles that includes: providing articles each having a first primary surface and a second primary surface, the first and second primary surfaces having one or more asymmetric surface features; providing a first ion-exchange bath; and performing an ion-exchange step by submersing the articles in the first ion-exchange bath to form strengthened articles. The articles are arranged in the first ion-exchange bath with the first primary surface of each facing the first primary surface of another of the articles at a first predetermined distance, and the second primary surface of each is facing the second primary surface of another of the articles at a second predetermined distance. The first predetermined distance and the second predetermined distance are selected such that the plurality of strengthened articles have a first strengthened surface with a convex surface, and a second strengthened surface with a concave surface.
Patent WO-2020209884-A1 (WO)
Title: Cellule de mémoire reram comprenant une commande de ligne de mots double
Inventor: NGUYEN VICTOR
IPC: G11C13/00
Filed: 2019-07-23
Abstract: L'invention concerne une cellule de mémoire ReRAM qui comprend un dispositif ReRAM comprenant une couche d'électrolyte solide disposée entre une première électrode source d'ions et une seconde électrode et un circuit de sélection comprenant deux transistors de sélection connectés en série connectés en série avec le dispositif ReRAM, chacun des deux transistors de sélection connectés en série comprenant une grille connectée à une ligne de commande séparée.
Patent WO-2020041355-A1 (WO)
Title: Dc-dc converter with current sensing and control
Inventor: TEPLECHUK MYKHAYLO
IPC: H02M1/00
Filed: 2019-08-20
Abstract: A voltage regulator utilizes a non-invasive sensing capacitor in differentially sensing a current indicative of current of an output capacitor of the voltage regulator. Some embodiments utilize current mirrors and an inverter for determining if the current indicative of current of the output capacitor is above or below a particular magnitude. Some embodiments utilize information indicative of output capacitor current in determining duty cycle for a switching voltage regulator, and some embodiments utilize the information in activating transient control circuitry.
Patent WO-2020041464-A1 (WO)
Title: Coated open-cell polyurethane foam structures with thermal absorption capabilities
Inventor: AOU KAORU
IPC: A47C27/14
Filed: 2019-08-21
Abstract: The present disclosure provides for a coated flexible open-cell polyurethane foam structure. The coated flexible open-cell polyurethane foam structure includes a flexible open-cell polyurethane foam having a first major surface and a second major surface opposite the first major surface. The coated flexible open-cell polyurethane foam structure further includes a flexible heat conductive material covering 30 to 90 percent (cov., expressed in %) of a surface area of the first major surface of the flexible open-cell polyurethane foam in a predefined shape to provide one or more gaps exposing the flexible open-cell polyurethane foam between defined edges of the flexible heat conductive material, where each gap of the one or more gaps has a gap width according to Formula I: gap width (mm) <u><</u> -0.196 x cov. (%) + 20.6 (Formula I) where a total surface area of the one or more gaps provides 70 to 10 percent of the surface area of the first major surface of the flexible open-cell polyurethane foam.
Patent WO-2020051341-A1 (WO)
Title: Personalized device to automatically detect and reduce muscle spasms with vibration
Inventor: THOMAS CHRISTINE
IPC: A61B5/0488
Filed: 2019-09-05
Abstract: A personalized wearable device can detect muscle contractions, such as spasms, and provide vibrational energy that treats these muscle contractions.
Patent WO-2020086886-A1 (WO)
Title: Molécule du récepteur d'il4/il13 à usage vétérinaire
Inventor: ZHAN HANGJUN
IPC: C07K19/00
Filed: 2019-10-24
Abstract: L'invention concerne divers modes de réalisation se rapportant à des protéines hétérodimères d'IL13R/IL4R dérivées d'espèces d'animaux de compagnie et qui se lient à l'IL13 et/ou l'IL4. De telles protéines hétérodimères peuvent être utilisées dans des méthodes de traitement d'états induits par l'IL13 et/ou l'IL4 chez des animaux de compagnie, tels que des canidés, des félidés et des équidés.
Patent WO-2020092573-A1 (WO)
Inventor: VLEUGELS KATELIJN
IPC: G16H20/17
Filed: 2019-10-30
Abstract: An automated medication dispensing system provides for triggering a medication administration message when an inferred event is detected for which a medication administration message is to be sent. The event might be the start, the beginning, or an anticipation of a start, of an eating event, detected by an event detection module from gestures of a user from a set of sensor readings. The message can be a signal to medication dispensing apparatus, and/or a reminder message to the user, an ancillary message to a caregiver, health professional, or others. The medication administration message might comprise a signal to an input of an insulin management system or an input of a meal-aware artificial pancreas. The events might also include a drinking event, a smoking event, a personal hygiene event, and/or a medication related event.
Patent WO-2020118187-A1 (WO)
Inventor: GIL JULIO
IPC: A47G29/14
Filed: 2019-12-06
Abstract: A containment unit that facilitates delivery of parcels using drones is provided. An example containment unit comprises an inner housing unit and an outer housing unit. The inner housing unit includes a first and second sidewall that are connected by an end piece and have a bottom opening in between. The inner housing unit is movable from a retracted position over a floor of the containment unit to an extended position, where a portion of the opening is extended beyond the floor. A parcel may be inserted into a volume of space within the inner housing unit from below through the opening and pulled into the containment unit by the end piece when the inner housing unit is retracted. The containment unit can be used as part of a drone delivery system that can also include an elevated delivery platform, a computer application, or any combination of these aspects.
Patent WO-2020131776-A1 (WO)
Inventor: FULLER KAY
IPC: A61M16/04
Filed: 2019-12-17
Abstract: A tracheal tube (e.g., an endotracheal tube) includes an inserting cannula (that may be able to swivel), and wherein the inserting cannula is connected to an elbow adaptor through a Bayonet Neill-Concelman (BNC) connection. The BNC connection may provide more secure connection of the corresponding components and may be able to withstand greater amounts of force exerted on them without becoming detached from each other. The elbow adapter may further be coupled to a pressure release valve that will alleviate pressure buildup within the tracheal tube.
Patent WO-2020180391-A1 (WO)
Inventor: WAN NOEL
IPC: B82Y20/00
Filed: 2020-01-06
Abstract: A process is provided for the high-yield heterogeneous integration of "quantum micro-chiplets" (QMCs, diamond waveguide arrays containing highly coherent color centers) with an aluminum nitride (A1N) photonic integrated circuit (PIC). As an example, the process is useful for the development of a 72-channel defect-free array of germanium-vacancy (GeV) and silicon-vacancy (SiV) color centers in a PIC.Photoluminescence spectroscopy reveals long-term stable and narrow average optical linewidths of 54 MHz (146 MHz) for GeV (SiV) emitters, close to the lifetime-limited linewidth of 32 MHz (93 MHz). Additionally, inhomogeneities in the individual qubits can be compensated  in situ  with integrated tuning of the optical frequencies over 100 GHz. The ability to assemble large numbers of nearly indistinguishable artificial atoms into phase-stable PICs is useful for development of multiplexed quantum repeaters and general-purpose quantum computers.