baber/WOPTO huggingface dataset:
Patent CA-2265917-A1 (CA)
Inventor: AGRAWAL SUDHIR
IPC: A61K31/7115
Filed: 1997-09-10
Abstract: The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides modified oligonucleotides that inhibit gene expression and that produce fewer side effects than conventional phosphorothioate oligonucleotides. In particular, the invention provides modified CpG-containing oligonucleotides that result in reduced splenomegaly and platelet depletion when administered to a mammal, relative to conventional CpG-containing phosphorothioate oligonucleotides. The ivnention further provides methods for using such oligonucleotides to modulate gene expression in vivo, including such use for therapeutic treatment of diseases caused by aberrant gene expression.
Patent CA-2269917-A1 (CA)
Inventor: LEWIS TERENCE
IPC: C07D451/02
Filed: 1997-10-30
Abstract: The present invention concerns bicyclic amine derivatives of formula (I) wherein R1 is an optionally substituted 5-membered heterocyclic ring system containing from 1 to 3 heteroatoms individually selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, wherein the substituents, if present, are selected from halogen atoms, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl alkylthio and alkyl amino groups, any of which groups contain up to eight carbon atoms, and wherein two substituents may join to form a fused ring; R2 represents hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkenyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl or XR3 (where X  represents oxygen or a group NR4), provided that when R2 is alkenyl, aralkenyl or alkynyl said group does not have an unsaturated carbon atom bonding directly to the ring nitrogen of formula (I); R3 and R4 are, independently, hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl or carboxylic acyl;  alkyl moieties of R2, R3 and R4 comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl, alkyl, amino, acylamino, imidate and phosphonato groups; or an acid addition salt, quaternary ammonium salt or <u>N</u>-oxide derived therefrom; to processes for preparing them, to insecticidal compositions comprising them and to methods of using them to combat and control insect pests.
Patent CA-2270768-A1 (CA)
Title: Custom optical filters
Inventor: DELISLE VINCENT
IPC: G02B5/20
Filed: 1999-05-04
Abstract: This invention relates generally to custom optical filters such as filters relating to, flat-top WDM multiplexer/demultiplexers, flat-top and peaky comb filters or reconfigurable add & drop filters. The embodiment disclosed below is based on mid-dispersion wavelength bands processing, wherein the optical spectrum is dispersed in two steps; in-between these two steps, the wavelength bands are manipulated in the focal plane, for example by being moved, reflected, absorbed, inverted, magnified or reduced to achieve a particular result. A masked mirror or masked transmissive element selects wavelength by position. The mask shape for relatively complex filtering functions is much simpler than currently used for collimated beams because of the correlation between position and wavelength. Inversion of channel bands or movement of channel bands in two dimensions in the focal plane, in particular, enables the construction of numerous useful devices. It is possible to realize custom flat-top optical filters, custom shaped optical filters, flat-top WDM multiplexer/demultiplexers, flat-top and peaky comb filters or reconfigurable add & drop filters.
Patent CA-2274776-A1 (CA)
Title: Method for analyzing annexin v in urine and use thereof
Inventor: MATSUDA TAKAKO
IPC: G01N33/53
Filed: 1998-10-08
Abstract: A method for analyzing annexin V in urine whereby annexin V can be conveniently measured without resort to the addition of chemicals in the measurement step for preventing various proteins from binding to calcium ions, preparing specimen solutions, etc.;  analytical reagents therefor; and a diagnostic method and diagnostics for organ disorders, etc. based on the above method and reagents for analyzing annexin V. The concentration of annexin V in urine can be determined by bringing the urine into contact with an antiannexin V  monoclonal antibody, thus effecting an antigen-antibody reaction between annexin V in the urine and the above antibody to thereby form an annexin V antigen-antiannexin V monoclonal antibody complex, and then quantitating the complex thus formed. The analytical data on the annexin V in the urine thus determined are usable in the diagnosis of disseminated intravascular coagulation syndrome, acute nephritis, etc.
Patent CA-2275237-A1 (CA)
Title: Pixel reordering for improved texture mapping
Inventor: KUO DONG-YING
IPC: G06T15/10
Filed: 1997-12-19
Abstract: A system and method for reordering memory references for pixels to improved bandwidth and performance in texture mapping systems and other graphics systems by improving memory locality in conventional page-mode memory systems.  Pixel memory references are received from a client graphics engine and placed in a pixel priority heap (202). The pixel priority heap (202) reorders the pixel memory references so that references requiring a currently open page are, in general, processed before references that require page breaks.  Reordered pixel memory references are transmitted to a memory controller (204) for accessing memory (205, 207).
Patent CA-2275438-A1 (CA)
Title: Improved methods for transducing cells
Inventor: DONG ZHONGYUN
IPC: A61K38/19
Filed: 1997-11-19
Abstract: Disclosed are compositions and methods for inhibiting the expression and/or activity of endogenous .beta.-interferon in cells targeted for transduction with viral vectors, particularly adenoviral vectors. Therefore, also provided are improved methods for treatment of genetically-based diseases by gene therapy. Also disclosed are methods for the treatment of neovascularization-related diseases, for examples, cancer, by the production in vivo of angiostatin, which inhibits the formation of new blood vessels. In particular embodiments, this is accomplished by transduction of macrophages ex vivo with a GM-CSF gene, thereby inducing the secretion of macrophage metalloelastase, which converts plasminogen to angiostatin. The transduced macrophages, when administered, naturally home to tumor sites to effectively localize the therapeutic effect.
Patent CA-2278729-A1 (CA)
Title: Production of alkyl aralkyl ketones from allylic-aralkenyl secondary alcohols
Inventor: BELMONT STEPHEN E
IPC: C07C45/51
Filed: 1998-02-18
Abstract: The process forms an alkyl aralkyl ketone from an aralkenyl secondary alcohol having an allylic double bond relative to the hydroxycarbinyl group, and having the allylic double bond positioned between the aryl moiety and the hydroxycarbinyl group. This is accomplished by heating the alcohol in a chemically indifferent organic liquid medium to which a catalytic quantity of an iron polycarbonyl has been added, so that an internal rearrangement occurs. Among the ketones that can be efficiently produced in this manner is nonsteroidal antiinflammatory agent, 4-(6'-methoxy-2'-naphthyl)-butan-2-one, generally known as nabumetone.
Patent CA-2280001-A1 (CA)
Title: Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
Inventor: YANG SHUWEI
IPC: C12Q1/68
Filed: 1998-02-09
Abstract: The present invention provides methods for use in identifying, analyzing and typing polymorphic DNA fragments, particularly minisatellite, microsatellite or STR DNA fragments. In particular, the invention provides methods using DNA polymerases, more particularly thermostable DNA polymerases, and most particularly Thermotoga polymerases or mutants or derivatives thereof, whereby minisatellite, microsatellite or STR DNA molecules may be amplified and analyzed for polymorphisms. The invention also relatesto polymerases having reduced, substantially reduced or eliminated ability to add non-template 3' nucleotides to a synthesized nucleic acid molecule. In accordance with the invention, such reduction or elimination may be accomplished by modifying or mutating the desired polymerase.
Patent CA-2280421-A1 (CA)
Title: Damper valve for hydraulic power steering device
Inventor: AIKO SATOSHI
IPC: B62D5/07
Filed: 1999-08-16
Abstract: A damper valve for a hydraulic power steering device where the damper valve is disposed at any portion of a hydraulic oil circuit connecting a changing-over valve in a gear box and a power cylinder, including a partition member for partitioning the interior of a valve casing into two chamber, and a shaft member extending through a central portion of the partition member, wherein a first valve mechanism allowing hydraulic oil to flow only in one direction is provided in the partition member, and a second valve mechanism allowing hydraulic oil to flow only in the other direction is provided in the shaft member. The first valve mechanism includes a plurality of communication holes formed in the partition member and a leaf spring for opening/closing the plurality of communication holes. The second valve mechanism includes ball type check valve. Flow of hydraulic oil in the other direction is an outward flow directed from the changing-over valve towards the power cylinder.
Patent CA-2281313-A1 (CA)
Title: Thread insert having detachable tongue
Inventor: SATO TAKASHI
IPC: F16B37/12
Filed: 1999-08-31
Abstract: The thread insert of the present invention comprises a helical body having a front end portion (3) and a back end portion (6), and a detachable tongue (4) connected to the front end portion (3) of the helical body, and a pair of engaging notches (10) are formed in the back end portion (6). A female thread (2) is formed on an inner surface of the helical body, a male thread (1) is formed on an outer surface of the helical body. The detachable tongue (4) has a circular portion (3a) having an outer diameter which is smaller than that of the helical body. A cutting notch (11) is formed between the front end portion (3) and the circular portion (3a) on at least one of a surface facing backward and a inner surface of the helical body.
Patent CA-2286426-A1 (CA)
Title: Automatic decking and automatic fastening system
Inventor: CAMPBELL JOHN
IPC: B62D65/18
Filed: 1999-10-14
Abstract: A vehicle assembly system automatically decks and automatically fastens body components to chassis components. The system uses an automatic decking and fastening unit that includes a base with an elevatable platform repositionable relative to the base by at least one actuator.      A slidable unit carries a fastener driver, is supported on the elevatable platform, and is repositionable relative to the elevatable platform by at least one other actuator. The slidable unit also carries an arm that is repositionable relative to the slidable unit by yet another actuator. A pair of conveyors are positioned away from the base, are movable relative to the base and carry a pair of vehicle components. The conveyors are cycled so that the vehicle components are positioned relative to one another in a predetermined position, and the actuators are operated to reposition the fastener driver to a position determined by engagement of the slidable unit with one of the vehicle components.
Patent CA-2287749-A1 (CA)
Inventor: GINGRAS MARC M
IPC: H01R4/66
Filed: 1999-11-01
Abstract: The invention relates to a method and apparatus for electrically grounding poles or posts which are used in electrical and/or telecommunication networks. The system includes a conductive base support affixed at or near the base of the pole and to which the ground wire is attached. The base support not only provides resistance to lateral forces, thereby anchoring the bottom of the pole, but also presents a relatively large surface area for electrical bonding with the soil/earth at the bottom of the pole which facilitates grounding.
Patent CA-2291196-A1 (CA)
Title: 1:2 chromium complex dyes, the production and use thereof
Inventor: KOERTE KLAUS
IPC: C25D11/18
Filed: 1998-05-19
Abstract: The invention relates to 1:2 chromium complex dyes of formula (I), in which R  is C1-9 alkyl or a radical of formula (a) or (b), R1 is C1-4-alkyl, R2 is hydrogen or -SO3M, R3 is hydrogen, methyl or methoxy, R4 is hydrogen, methyl, methoxy or chlorine, n is 0-3, M is hydrogen or a non-chromophoric cation, and Kat+ is hydrogen or a non-chromophoric cation. Said dyes can be used for dying artificially produced oxyde films on aluminium or aluminium alloys, on which they yield highly light-fast colouring in yellow tones.
Patent CA-2291730-A1 (CA)
Inventor: YANG MARY M
IPC: G01N21/27
Filed: 1998-06-05
Abstract: On utilise des appareils, des logiciels d'imagerie, des agents d'étalonnage et des procédés d'imagerie pour visualiser et quantifier la quantité des transferts d'énergie de résonance par fluorescence (TERF) qui existent entre des molécules donneuses et des molécules accepteuses en microscopie (1) par épifluorescence. Le système MicroFRET compense le chevauchement des spectres de molécules donneuses, des molécules accepteuses et du TERF, en utilisant des billes fluorescentes bien caractérisées servant d'étalons de mesure, conjointement avec des techniques de traitement d'images radiométriquement étalonnées. Le système MicroFRET utilise également des cubes (4) d'épifluorescence usinés avec précision pour maintenir le bon alignement de l'image lorsque l'échantillon est éclairé (3) aux longueurs d'ondes d'excitation des molécules donneuses et accepteuses. On décrit des algorithmes qui pseudocolorent l'image pour présenter des pixels mettant en évidence l'émission de fluorescence radiométriquement corrigée entre les molécules donneuses (bleue), les molécules accepteuses (vert) et le TERF (rouge). Le procédé est utilisé sur des échantillons présentant un transfert d'énergie de résonance par fluorescence (TERF) entre des dérivés produits par génie génétique de la protéine fluorescente verte (PFGV) liée à la surface de billes chélatantes Ni par des marqueurs histidines.
Patent CA-2292043-A1 (CA)
Inventor: CISTERNINO FRANCESCO
IPC: H04J3/00
Filed: 1999-12-10
Abstract: A method of and a device for optical demultiplexing that are based on the four wave mixing between the signals to be demultiplexed and pump signals. The two signals are fed into a polarisation maintaining fibre, which divides them into two components with orthogonal polarisation, separated in time; and the four wave mixing is performed separately on the two components, thereby originating two separate signals that are polarisation-rotated and recombined.
Patent CA-2292265-A1 (CA)
Title: One-part resin compound with improved adhesive properties, for use as a sealant
Inventor: BINDSCHEDLER PIERRE ETIENNE
IPC: C08L95/00
Filed: 1999-12-14
Abstract: One component resin composition comprises bitumen and a polyurethane prepolymer in which the molecules have at least one segment or group comprising ≥ 30 purely hydrogen substituted carbon atoms. Independent claims are also included for the following: (1) creating a sealant coating as a vertical, horizontal or inclined extension of an existing traditional sealant coating, comprising applying at least one layers of the composition to an unprimed support surface; (2) creating a sealant coating on part (A) of a vertical or inclined surface connected to a bituminous sealant coating (B) on a principal support surface (C), comprising applying a layer of the composition to cover part (A), a border strip of coating (B) and optionally an adjacent portion of surface (C), and optionally, after the layer of the composition has at least partially dried, applying a second layer of the composition.
Patent CA-2292433-A1 (CA)
Title: Method of molding edible starch
Inventor: AXELROD GLEN S
IPC: A23K1/14
Filed: 1999-12-17
Abstract: A process for forming starch into a molded article using melt processing techniques which process comprises combining starch and water to form a mixture wherein the water content is in the range of about 20.0 to 40.0 % by weight with respect to that of the starch and introducing and heating the mixture in an extruder wherein the water content of said product upon discharge from said extruder is less than the water content of the mixture entering said extruder. The extrudate is then, optionally dried, and introduced to a heated injection molding machine and injection molding and cooled to form a molded article wherein the water content of the molded article is at or below about 20 % by weight.
Patent CA-2297764-A1 (CA)
Inventor: BOVA DAVID J
IPC: A61K9/22
Filed: 1998-07-31
Abstract: The present invention relates to solid pharmaceutical combinations for oral administration comprising nicotinic acid or a nicotinic acid compound or mixtures thereof in an extended release form and an HMG-CoA  reductase inhibitor, which are useful for altering lipid levels in subjects suffering from, for example, hyperlipidemia and atherosclerosis, without causing drug-induced hepatotoxicity, myopathy or rhabdomyolysis. The present invention also relates to methods of altering serum lipids in subjects to treat, for example, hyperlipidemia in hyperlipidemics, lipidemia in normolipidemics diagnosed with or predisposed to cardiovascular disease, and atherosclerosis, by administering such oral solid pharmaceutical combinations once per day as a single dose during the evening hours, without causing drug-induced hepatotoxicity myopathy or rhabdomyolysis, or without causing in at least an appreciable number of individuals drug-induced hepatotoxicity, myopathy or rhabdomyolysis to such a level that discontinuation of such therapy would be required. More particularly, the present invention concerns oral solid pharmaceutical combinations comprised of, for example, (1) an HMG-CoA reductase inhibitor for immediate or extended release, (2) nicotinic acid, a nicotinic acid compound or mixtures thereof, and (3) a swelling agent to form a sustained release composition for extended release of the nicotinic acid or nicotinic acid compound or mixtures thereof for nocturnal or evening dosing for reducing serum lipids and increasing HDL-cholesterol. In accordance with the present invention, and by way of example, a composition for oral administration during the evening hours to alter serum lipids comprised of nicotinic acid and hydroxypropyl methylcellulose in the form of an extended or sustained release tablet or caplet coated with a coating comprising an HMG-CoA reductase inhibitor in immediate release form is disclosed. Also in accordance with the present invention, the pharmaceutical combinations may include a nonsteroidal and-inflammatory agent for reducing the capacity of nicotinic acid or nicotinic acid compounds to provoke flushing reactions in individuals.
Patent CA-2303226-A1 (CA)
Title: Process for producing spinel type lithium manganate
Inventor: NUMATA KOICHI
IPC: H01M4/58
Filed: 1999-06-08
Abstract: A process of producing spinet-type lithium manganate which is characterized by comprising pulverizing electrodeposited manganese dioxide, neutralizing the powder with sodium hydroxide or sodium carbonate to a pH of 2 or higher, mixing the electrolytic manganese dioxide with a lithium raw material, and firing the mixture.
Patent CA-2303831-A1 (CA)
Title: Noise suppression and sound proof chambers
Inventor: ADAMS ALBERT G
IPC: G10K11/16
Filed: 2000-03-27
Abstract: The principal object of the present invention relates to the provision of:   a) A Noise Suppression Chamber (450)- Mark I b) A Sound Proof Chamber (10)- Mark I c) An Electronic Surveillance Bug Proof Chamber - Mark II   In case (a) whereby functioning as a low level noise suppression chamber (450) to maintain quiet without adjacent areas in the presence of a noise source propagated from within as per Fig. No. 71. In case (b), and case (c) whereby maintaining privacy and integrity of sounds source propagated from within, by restricting its transmission to without said chambers. The latter case (c) is an enhancement of the former case (b). Wherein each of these aforementioned cases having a sealed cavity between all boundary internal, and external surfaces that form said plastic enclosures, comprising a continuous vacuumed cavity roof, and walls having access opening and door, with or without an integral vacuumed cavity floor (20), (42), (43).  By implementing sound absorbing acoustics, and radio frequency blocking surfacing materials, in combination with an electronic signal transmitting detection device, whereby to restrict, detect, and alert of impending violation, and to subject said cavity to a partial vacuum of specified pressure, all as per drawing sheets 1 to 16. Environmental HVAC assist, or attenuated air exchange - air revitalization (334), choice of ventilation system is dependent on THINK TANK  functionality. It is proposed to manufacture THINK TANK in a variety of colors, and incremental sizes, for distribution to the consumer in assembly kit form.
Patent CA-2303881-A1 (CA)
Title: Tamper indicating closure with foldable tab
Inventor: KRUEGER DAVID F
IPC: B65D41/34
Filed: 1999-07-28
Abstract: A tamper indicating closure according to the present invention includes a top wall (22) and a skirt (24) depending from the top wall (22). A tamper indicating band is connected to the skirt along a frangible line. The tamper indicating band includes a ring (30) and at least one tab (34), the at least one tab (34) having a bi-stable geometric shape. In particular, the tab (34) includes a pair of extending members (36) angled toward one another and connected by a transverse member (38). The shape of the tab (34) allows it to be molded in a downward orientation and later folded to a stable, upward orientation without reheating or otherwise resetting the tab.
Patent CA-2304411-A1 (CA)
Inventor: NAKANO TAKUJI
IPC: A63C5/00
Filed: 2000-04-04
Abstract: Présentation d'un ski de direction pour une motoneige. Le ski de direction comprend un corps de ski et une barre d'usure reliés à une fixation de ski. La fixation de ski sert à attacher le ski à la planche  de la motoneige. Le corps de ski reçoit également un élément de renfort qui renforce la partie courbée vers le haut du corps de ski. Des nervures de renfort se trouvent sur toute la longueur de la partie supérieure du corps de ski. La semelle ou face inférieure du ski dispose d'une quille qui s'étend en largeur depuis la partie avant, puis se rétrécie en largeur à l'arrière de la jointure entre la partie en contact avec la neige du corps du ski et la partie qui s'étend vers le haut du corps de ski. Une barre d'usure est positionnée le long de la quille et repose sous la partie inférieure de la quille à l'arrière de la plus grande partie de la quille. La barre d'usure passe dans le corps du ski par une ouverture vers l'avant et une ouverture vers l'arrière. L'ouverture vers l'arrière est dimensionnée et configurée de façon laisser passer les morceaux de glace à travers le corps du ski et va vers le haut afin de refroidir les différents composants de la motoneige.