baber/WOPTO huggingface dataset:
Patent EC-SP961698-A (EC)
Title: Inhibidores de transferasa de proteina farnesilada
Inventor: ANTHONY NEVILLE J
IPC: C08G69/42
Filed: 1996-03-26
Abstract: La presente invención está dirigida a compuestos que inhiben a la transferasa de proteína farnesilada (Ftasa) y a la farnesilación de la proteína del oncogén Ras. La invención está dirigida adicionalmente a composiciones quimioterapéuticas que contiene los compuestos de esta invención y a métodos para inhibir la transferasa de proteína farnesilada y la farnesilación de la proteína del oncogén Ras.
Patent EC-SP982724-A (EC)
Title: Nitrilos de dipeptido
Inventor: BETSCHART CLAUDIA
IPC: C12Q1/00
Filed: 1998-11-04
Abstract: Los nitrilos de dipéptido N-terminal-sustituidos como se definen, son útiles como inhibidores de catepsinas de cisteína, poe ejemplo, catepsinasB, K, L, YS, Y se pueden utilizar para el tratamiento de enfermedades y condiciones dependientes de catepsinas de cisteína, incluyendo inflamación, artritis reumatoide, osteoartritis, esteoporosis, tumores (especialmente invación tumoral y metástasis tumoral), enfermedad coronaria, ateroesclerosis (incluyendo ruptura y desestabilización de la placa ateroesclerótica). Los nitrilos de dipéptido particulares son compuestos de la fórmula I, o ésteres fisiológicamente aceptables y disociables o sales de los mismos, (gráfico), en donde: los simbolos son como se definen. En particular, se ha descubierto que mediante la elección apropiada de los grupos R, R2, R3, R4, R5, X1 Y y L, se puede alterar la selectividad relativa de los compuestos como inhibidores de los diferentes tipos de catepsinas de cisteína, por ejemplo, las catepsinas B, K, L y S por ejemplo, para obtener inhibidores que inhiban selectivamente un tipo de catepsinas particular, o una combinación de tipos de catepsinas.
Patent EC-SP993039-A (EC)
Title: Compuestos beta- lactama y su uso como inhibidores de triptasa
Inventor: ZAHLER ROBERT
IPC: C07D205/00
Filed: 1999-06-24
Abstract: Los compuestos de las fórmulas: (gráficos), se describen. Estos compuestos inhiben la triptasa asi como otros sistemas de enzimas y son útiles como agentes antiinflamatorios particularmente en el tratamiento del asma crónico.
Patent EC-SP993273-A (EC)
Title: Inhibidores de transferasa de proteina farnesilo
Inventor: COOPER ALAN B
IPC: C07D403/14
Filed: 1999-12-16
Abstract: Se describen compuestos que tiene la fórmula (gráfico), en la cual R13 representa un anillo imidazol; R14 representa un grupo carbamato, urea, amida o sulfonamida; R8 representa H, cuando la cadena alquilo entre el grupo amida y el grupo R13 imidazol está sustituido, o R8 representa un sustituyente tal como arilalquilo, heteroarilalquilo o cicloalquilo, y los sustituyentes remanentes son tal como se definen aqui. También se describen compuestos en los cuales R8 es H, y la cadena alquilo entre el grupo amida y el grupo imidazol R13 está no sustituido. Se describe también un método para tratar cáncer y un método para inhibir la transferasa de proteina farnesilo usando los compuestos descriptos.
Patent FI-20010792-A (FI)
Inventor: VIIKKI OLLI
IPC: G10L15/30
Filed: 2001-04-17
Abstract: A method needed in speech recognition for forming a pronunciation model in a telecommunications system comprising at least one portable electronic device and server. The electronic device is arranged to compare the user's speech information with pronunciation models comprising acoustic units and stored in the electronic device. A character sequence is transferred from the electronic device to the server. In the server, the character device is converted into a sequence of acoustic units. A sequence of acoustic units is sent from the server to the electronic device. <IMAGE>
Patent FI-20035102-A (FI)
Inventor: PARVIAINEN MAURI
IPC: H01R24/78
Filed: 2003-06-19
Abstract: The invention relates to a 2-gang socket-outlet, comprising a body (3) of insulating material, a mounting plate (2), having the body (3) attached thereto, metallic terminal units (4), including first connectors (4.1) fitting for contact with the prongs of electric plugs and second connectors (4.2) intended for contact with electric wires, and a housing section (1), constituting a cover or a case which conceals an interior (5) of the socket-outlet. The socket-outlet interior (5) comprises at least the body (3) and the terminal units (4) and usually also a child protector. The body (3) is fitted with a separate insulating element (6, 8) for covering the terminal units (4) along with the connectors (4.1, 4.2) thereof, such that, once installed, the socket-outlet interior (5) is screen-protected without the housing section (1). This enables manufacturing simple housing sections (1) in diverse materials, colours and shapes, which include neither child protectors nor other technology. <IMAGE>
Patent FI-20050742-A (FI)
Inventor: FRIMAN OLLI
IPC: A63C/
Filed: 2005-07-11
Abstract: A shield plate ( 2 ) of a wheel roller bearing of a roller skate, which is installed outside the roller bearing for preventing the contamination of the roller bearing, characterized in that the shield plate extends over the outer race ( 7 ) of the roller bearing and that the shield plate is fixed directly or by means of attachments tightly on the inner race ( 10 ) of the roller bearing.
Patent FI-20055199-A (FI)
Inventor: PENSAR JOHAN
IPC: F02M51/00
Filed: 2005-04-28
Abstract: A control arrangement for a fuel injection apparatus of an internal combustion engine, the fuel injection apparatus comprising at lest two fuel injector nozzles, the injection action of which is controllable via a solenoid, and at least two control units arranged to control the solenoids controlling the injection action. According to the invention, each injector nozzle is provided with a first and second solenoid and the first and second solenoid are in connection with a different control unit.
Patent GB-1052165-A (GB)
IPC: B41F13/14
Abstract: 1,052,165. Printing-apparatus. DRUCKMASHINENWERK PLANETA VEB. May 19, 1965, No. 21178/65. Heading B6C. [Also in Division F2] In a rotary multi-colour printing machine, adjacent side walls of the frames 1, 3 of the various printing units or assemblies, e.g. the inking, feeding &c. mechanisms, are interconnected with a selected spacing by means of fitting members 2, the spacing between the side walls being sealed by resilient members, Fig. 3 (not shown). The units 1, 3 may be mounted on separate base members 4, 5 or on a common base member. Each fitting member is formed generally as a washer which surrounds a screw, the washer being of laminated foil, of wedge formation, or adjustably threaded, Figs. 4-6 (not shown). Such base-plate is vertically adjustable by means of threaded spindles 14 and a projection on the frame 1 supports laterally adjustable threaded spindles 15 which may engage the walls of the frame 3.
Patent GB-1053390-A (GB)
IPC: D02G3/40
Abstract: 1,053,390. Coated elastameric yarns; warping. WYOMISSING CORPORATION. April 23, 1964 [April 24, 1963], No 16803/64. Headings D1F, DIM and D1W. A plurality of elastomeric yarns-e.g. of rubber or spandex-are covered by an adhesive having an elongation when set or cured similar to that of the yarns by passing the yarns whilst elongated in side-by-side relationship to the adhesive applying device 30. Flock may be applied to the adhesively coated yarns in chamber 20, the adhesive being set or cured by the warm current of air in chamber 20 and by oven 60. The pump extracting the flock loaded air from chamber 20 has a greater capacity than the pump feeding the flock and air thereto, air being drawn in from the outside to make up the difference and thus to prevent loss of fibres. Rollers 18 elongate the yarns by the required amount. The above process may be carried out while the yarns are being fed to warp beam B, there being a common drive for packages P in the creel, feed rolls 18, and drive roll 25 of beam B.
Patent GB-1084149-A (GB)
IPC: H03C1/00
Abstract: 1,084,149. Amplitude modulating apparatus. FORD MOTOR CO. Nov. 24, 1965 [Dec. 2, 1964], No. 49840/65. Heading H3R. [Also in Division H1] An alternating current is caused to divide and flow through two parallel superconducting paths, a relative phase shift introduced into the paths resulting in amplitude modulation of the currents when re-combined. The apparatus shown in Fig. 3 comprises a layer of tin d on a quartz substrate Q coated with insulation A and oxidized on the non-coated areas at the edges; a further layer of tin C is deposited over the insulation and over the oxide areas. Lead-in wires (not shown) are attached to' the tin layers C and d and are therefore connected by two parallel paths passing respectively through the two oxide layers. When the apparatus is cooled to superconducting temperatures the current may be modulated either by varying a magnetic field or by rotating the apparatus about an axis perpendicular to area A. In another arrangement, Fig. 5 (not shown), a superconductor of generally square form has parts of. reduced cross-section in opposite sides of the square, these parts forming junctions when driven from the superconductive state to the nonsuperconductive state by an impressed current. The device is placed in the cavity of microwave apparatus, and the current is modulated by the micro-wave voltage appearing across the junctions.
Patent GB-1225494-A (GB)
IPC: G01N15/04
Filed: 1967-06-13
Abstract: 1,225,494. Determining particle size photoelectrically. T. ALLEN. June 7, 1968 [June 13, 1967], No. 27145/67. Heading G1A. In a method of determining the size distribution of fine particles in a particle-suspending lighttransmitting fluid the particles are allowed to settle through a beam of light passing through the fluid and both the transmitted light and scattered light falling on a detector, is compared with the output from a light reference detector on to which a second beam from the same source is directed through an adjustable aperture. The apparatus comprises a sedimentation tank 13, Fig. 1, with a stirrer 14 in a light proof enclosure 15. Stop 7 causes the beam to diverge over a wide angle on to detector 10.
Patent GB-1225549-A (GB)
IPC: C07C7/00
Filed: 1968-11-08
Abstract: 1,225,549. Isoprene. NIPPON PETROCHEMICALS CO. Ltd., and CHIYODA CHEMICAL ENG. & CONSTRUCTION CO. Ltd. 8 Nov., 1968 [11 Nov., 1967; 27 Jan., 1968], No. 53044/68. Heading C5E. Isoprene is recovered from a C 5  hydrocarbon mixture containing relatively large proportions of cyclopentadiene and acetylenes, by a process comprising the following steps:- (a) a first extractive distillation to separate most of the cyclopentadiene and acetylenes in the solvent, (b) subjecting the remainder of the fraction to a second extractive distillation to extract isoprene from pentanes and pentenes, and (c) fractionating the isoprene stream in two stages, in one of which isoprene is separated from lower boiling impurities and in the other from higher boiling impurities. The solvents in both of stages (a) and (b) may be an acetonitrile-water mixture. Between the two extractive distillation stages the isoprene stream may be selectively hydrogenated to convert any remaining acetylenes to olefins or paraffins. In stage (a) the crude isoprene may be removed as a side-stream, the overhead then comprising mainly pentanes and pentenes, thus lessening the loading on subsequent stages. Isoprene of better than 99À5% purity may be obtained.
Patent GB-1225712-A (GB)
IPC: A47G9/10
Filed: 1969-04-14
Abstract: 1,225,712. Cushions. M. RICHTER [trading as MANFRED RICHTER]. 14 April, 1969 [19 April, 1968], No. 19065/69. Heading A4M. A cushion is divided into three spaces 9, 10 and 11 by panels 7 and 8, the spaces being divided into chambers by longitudinal and transverse webs 12 and 15 and 13 and 19 respectively, chambers 14 of at least one of the outer spaces 9 and 10 being filled with high grade down, chambers 17 and 18 of the inner space 11 having resiliently elastic inserts and chambers 16 adjacent to 17 and 18 being filled with a soft padding material. The resilient elastic inserts may be of semi-rigid expanded plastics material but are preferably steel springs wound in spiral or coil form which are tied together under load and sewn into pockets or bags. The outer space not filled with high-grade down may be filled with low-grade down, unstripped quills, or vegetable or animal fibres.
Patent GB-1229738-A (GB)
IPC: F16K17/04
Filed: 1969-05-08
Abstract: 1,229,738. Valves. DRESSER INDUSTRIES Inc. 8 May, 1969 [27 June, 1968], No. 23569/69. Heading F2V. The closure member 22 of a relief valve is provided with a loosely mounted skirt 25 which is displaced into the position shown by the unbalanced fluid forces set up in the valve during its first operation, which skirt then presents asymmetrical areas to the controlled fluid to equalize the forces exerted on the closure member during subsequent opening of the valve. The Specification sets out optimum dimensions for the skirt.
Patent GB-1230622-A (GB)
IPC: F24H7/04
Filed: 1968-08-28
Abstract: 1,230,622. Thermal storage heaters. PARKINSON COWAN Ltd. 28 Aug., 1968, No. 41087/68. Heading F4U. The subject matter of this Specification is substantially the same as that of Specification 1,230,621, but the claims are concerned with the provision of the alternative heated air flow outlets.
Patent GB-1232842-A (GB)
IPC: H04N9/097
Filed: 1968-05-13
Abstract: 1,232,842. Colour television camera. RANK ORGANISATION Ltd. 7 May, 1969 [13 May, 1968], No. 22559/68. Heading H4F. [Also in Division G2] Apparatus for the separation of a polychromatic image into a plurality of component images of different chromatic characteristics may be used in a colour television camera 31 and comprises a fibre optic image splitter 37 formed from a coherent bundle of light conductive fibres having an input end 41 and an output end and a dispersing arrangement which may comprise a fibre optic image dissector 35 and a dispersing element consisting of lenses 38, 39 and a prism 40, the dispersing arrangement and the fibres being arranged such that beams of light of the same wavelength fall on to fibres which are grouped together at the output such that a component image of light of that wavelength is formed at the output end. As shown, Fig. 4C, the fibres of dissector 35 are arranged in layers 61 which are spaced apart at the output end 36 by a separation equal to at least twice their width so that the dissected image of an object 33 formed by an objective 32 upon the input face 34 of dissector 35 is separated into layers at the output face 36. The separated image is dispersed into its red, green, and blue components by the dispersing element which focuses the separated coloured images on to the input face 41 of image splitter 37 whose fibres are arranged in groups of three bands such that the dispersed image of each layer of the separated image at the output face 36 of the dissector 35 just covers a group of three bands with each band receiving a separate colour component (Fig. 5A). The fibres of image splitter 37 are arranged to give at the output end three output faces 42, 43, 44, each face being coupled with each third band on input face 41 to display red, green and blue images which are focused upon pick-up tubes 51, 52, 53 by lenses 45, 46, 47 respectively. Red, green and blue filters 48, 49 and 50 may be provided and resolution may be improved by employing wavelength multiplexing with the fibre optic components 35, 37 (see Fig. 6). Fibres with different transmission characteristics may be employed for different image displays.
Patent GB-1238669-A (GB)
IPC: B01J19/24
Filed: 1968-09-18
Abstract: 1,238,669. Mixing flowing streams; liquid/ liquid contact. UPJOHN CO. 18 Sept., 1968 [12 March, 1968], No. 44279/68. Headings B1C and B1F. In the production of isocyanates with reduction of secondary reactions, liquid phosgene from 3 is accelerated by the restriction of the flow path at 23 and meets a stream of liquid amine from 10 as it is injected, similarly accelarated from frusto-conical passage 26.
Patent GB-1251297-A (GB)
IPC: C07F7/22
Filed: 1969-02-28
Abstract: 1,251,297. Dibutyl tin maleates. M. & T. INTERNATIONAL N.V. 28 Feb., 1969 [29 Feb., 1968], No. 10783/69. Heading C2J. A dibutyl tin maleate is made by reacting substantially stoichiometric amounts of a dibutyl tin oxide and maleic anhydride (or maleic acid) in the presence of a reaction medium at least 75% of which consists of an inert cycloaliphatic hydrocarbon, such that the product may be crystallized from the reaction medium on cooling. Preferably, the reaction temperature is maintained at 60-100 C. In the examples, di-n-butyl tin oxide was reacted with maleic anhydride in cyclohexane, methyl cyclohexane, or cyclohexene alone or in admixture with some heptane.
Patent GB-1252020-A (GB)
IPC: B26B19/02
Filed: 1969-11-25
Abstract: 1,252,020. Dry shavers. SCHICK ELECTRIC Inc. 25 Nov., 1969 [3 March, 1969], No. 57591/69. Heading B4B. An adjustable head for a dry shaver comprises a pair of shaver heads 40, 50 mounted on a cradle 20 having a pair of flexible guide members 21, 22 which are provided with cam surfaces 23, 24 adapted to co-operate with cam surfaces 11, 12 on a spreader bar 10 so that when the spreader bar is raised the heads are moved outwardly thereby permitting hair-cutting surfaces 41, 51 thereon to be moved to a more exposed position so as to allow a closer shaver. The cradle is formed with relieved portions 25, 26, Fig. 1, so as to permit the guide members to flex when the spreader bar is raised by means of cam surfaces 15, 16 thereon being engaged by cam surfaces 31, 32 on a slidable bar 30. The shaver heads are retained on the cradle by means of a flexible clamp 60, Fig. 4. The haircutting surfaces 41, 51 are formed with a ridge which causes the skin to be stretched and so increase the closeness of the shave.
Patent GB-1252672-A (GB)
IPC: C08F226/02
Filed: 1969-02-11
Abstract: 1,252,672. 1-(N<SP>1</SP>-Benzylpiperazino)-butene-1. MONTECATINI EDISON S.p.A. 11 Feb., 1969 [16 Feb., 1968], No. 7217/69. Heading C2C. [Also in Division C3] 1-(N<SP>1</SP>-Benzylpiperazino)-butene-1 is prepared by reacting 1-benzylpiperazine with n-butyraldehyde in benzene in the presence of anhydrous potassium carbonate, whereby water is eliminated in the reaction and the product is recovered by distillation under reduced pressure.
Patent GB-1258077-A (GB)
IPC: H02K31/02
Filed: 1968-04-09
Abstract: 1,258,077. Homopolar machines. NATIONAL RESEARCH DEVELOPMENT CORP. 2 April, 1969 [9 April, 1968], No. 16983/68. Heading H2A. In a homopolar machine having a rotor sectorially divided into a plurality of conducting paths connected to rings of commutator segments for engagement by brushes which are interconnected so that alternate paths are connected in series, each of the sectors 21 ... 28 in the embodiment shown in Fig. 2a comprises a pair of parallel conducting paths 21a, 21b . . . 28a, 28b, each path being located close to a path in an adjacent sector so as to be closely coupled magnetically thereto whereby the resultant current in each such coupled pair of paths remains constant as the rotor rotates and sparking at the brushes is reduced. The magnetic coupling may be increased by forming each path as a plurality of bars which are interleaved with those of the path in the adjacent sector, Figs. 4 and 5 (not shown).
Patent GB-1258574-A (GB)
IPC: B02C18/28
Filed: 1968-07-20
Abstract: 1,258,574. Comminuting apparatus. O. KAY. 20 Oct., 1969 [20 July, 1968], No. 34744/68. Heading B2A. A paper reducing machine comprises two contra-rotatable frusto-conical, conical or substantially conical rotors 3 arranged horizontally in a casing 1 with their axes parallel. The casing has an inlet 20 and an outlet 28 at opposite ends of the rotors. As described, each rotor is of hexagonal cross-section tapered along its length, provided with projections 14 and belt driven via an individual electric motor 8. The projections comprise square plates 14a secured to angle sections 13, which are secured to an outer metal cover 12 of a respective rotor. Two inlets 20 are provided at opposite sides of the rotors. Baffles 21 prevent material being thrown back through the inlets and an elongate triangular formation 22 cooperates with the rotors. Material to be reduced is carried in spinal paths around the rotors and ultimately thrown out downwardly through the outlet 28, Fig. 3, to, e.g. a baling machine.
Patent GB-1264550-A (GB)
IPC: H01L35/32
Filed: 1969-07-22
Abstract: 1,264,550. Peltier cooler. SIEMENS A.G. 22 July, 1969 [23 July, 1968], No. 36882/69. Heading H1K. The elements 1 and copper bridges 2 of a Peltier cooler are soldered together and the assembly placed within a frame 4 of thermoplastic material which has projections 5 to support the leads 3 of the cooler. The structure is placed in the bottom of a tank containing a shallow layer of a hardenable casting resin to form a sealing layer 7 between the bridges and between bridges and frame. (Sealing layer 8 is also provided.) The structure is then inverted and a second sealing layer 6 is similarly formed so that the cooler is made a sealed unit which does not contain the usual solid interior insulation; heat leakage across the structure is thus avoided.
Patent GB-1265516-A (GB)
Inventor: HAJOS Z G
IPC: C07C62/26
Filed: 1969-10-02
Abstract: 1,265,516. Benz[e]indene derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 2 Oct., 1968 [4 Oct., 1968; 28 July, 1969], No. 45276/70. Divided out of 1,265,512. Heading C2C. Novel dodecahydrobenz[e]indene derivatives of the formula in which V represents hydrogen or a C 1-7  alkyl or aryl group or an alkali metal cation, R<SP>1</SP> 2  is hydrogen, C 1-7  alkyl, C 1-7  alkoxy-C 1-7  alkyl or phenyl-C 1-7  alkyl; R 4  is hydrogen or C 1-7  alkyl and R is a group of the formula  in which W is an alkylene or arylene radical, are prepared by hydrogenating a compound of the formula in which R 1  is a group of the formula (a) above and; if desired, cleaving the ketal group to obtain the compound in which R is (b) above. Catalytic hydrogenation over Pd/charcoa and hydrolysis of the ketal with dilute HCl are preferred. Examples describe the preparation of sodium salt and methyl ester of 3#-t-butoxy- 1,2,3,3a,4,5,5a,6,8,9,9a,9b - dodecahydro - 3a#- methyl - 6α - (3 - oxobutyl) - 7 - oxo - 7H- benz[e]inden - 8α - carboxylic acid and the ethylene ketals thereof.
Patent GB-1266852-A (GB)
IPC: B07B13/04
Filed: 1968-01-31
Abstract: 1,266,852. Grading and cleaning apparatus. F. S. DAVISON. 24 Feb., 1969 [31 Jan., 1968], No. 5022/68. Heading B2H. An apparatus for grading and cleaning root crops, e.g. potatoes, includes a screening structure 1 comprising a set of spaced-apart, stationary longitudinal members 12 disposed substantially horizontally and a set of spacedapart, resilient-surfaced transverse members 10, 11 arranged to move in the direction of the length of the longitudinal members and defining with the latter apertures through which undersize roots and waste soil are removed. The longitudinal members 12 may consist of strips of flexible material such as canvas or steel. The transverse members consist of cylindrical rubber bushes 11 axially mounted on and bonded to spindles 10 the ends of which are carried by chains 5 one on each side of the screening structure 1. A resilient spacer 13 is carried at the centre of each spindle between two bushes 11 to prevent excessive opening of the gauging apertures should roots become wedged. The roots are fed on to the screening structure 1 by means of an inclined conveyor 23. An endless conveyor 24 is arranged beneath the screening structure for removal of waste soil and rejected roots. A geared electric motor 25 drives the chains 5 through a driving spindle 2 and sprockets 3 at each end of the spindle. The transverse members are agitated as the ends of the spindles 10 pass over strips 28 whose upper surface is of ratchet form. A number of graders may be arranged in series with short conveyors extending between each pair of graders or the graders may be arranged in tiers.