baber/WOPTO huggingface dataset:
Patent CA-2492430-A1 (CA)
Title: Phenylalanine enamide derivatives
Inventor: BAILEY STUART
IPC: A61K31/496
Filed: 2003-07-16
Abstract: Phenylalanine enamide derivatives of formula (1) are described, wherein R1is a -CH(CH3)2, -(CH2)2CH3; -CH2C(CH3)3, -CH2CH2OH, -CH2CH2OCH3, -CH2CH2OCH2CH2OH, -CH2CH2OCH2CH2OCH3, formula (A) group; and the salts, solvates and N-oxides thereof. Compounds according to the invention are potent and selective inhibitors of .alpha.4 integrins. The compounds are of use in modulating cell adhesion and in particular are of use in the prophylaxis and treatment of diseases or disorders including inflammation in which the extravasation of leukocytes plays a role and the invention extends to such a use and to the use of the compounds for the manufacture of a medicament for treating such diseases or disorders.
Patent CA-2493230-A1 (CA)
Title: 5-substituted isoquinoline derivative
Inventor: SETO MINORU
IPC: C07D217/04
Filed: 2003-07-18
Abstract: A compound represented by the following formula (1): (1) wherein R1 represen ts hydrogen, halogeno, etc.; R2 represents hydrogen, halogeno, C1-6 alkyl, etc. ; R3 represents, e.g., -O-X-C(A1)(A11)-C(A2)(A21)-N(A31)(A3) (X represents propylene, etc.; A11 and A21 each represents hydrogen or C1-6 alkyl; A31 represents C1-6 hydroxyalkyl or hydrogen; and A1, A2, and A3 each represents hydrogen, C1-6 alkyl, etc.) or a salt of the compound. The compound or salt has myosin regulatory light-chain phosphorylation inhibitory activity and is useful in treatments for diseases to which contraction of various cells relates.
Patent CA-2496268-A1 (CA)
Title: Oligonucleotide tagged nucleoside triphosphates (otntps) for genetic analysis
Inventor: KUMAR SHIV
IPC: C12Q1/68
Filed: 2003-08-21
Abstract: Oligonucleotide tagged nucleoside triphosphates, OTNTPs, which are substrates for polymerases and or terminal nucleotidyl transferases are provided as well as methods of making these OTNTPs. Further provided are OTNTPs with fluorescent dyes including energy transfer dyes, attached to the oligonucleotide chain, OTNTPs with unnatural bases incorporated in the oligonucleotide sequence and methods for incorporating these OTNTPs in DNA or RNA. Also provided are methods for using the oligonucleotides on OTNTPs for amplifying the oligo sequence on the OTNTP using an amplification method described above. Further provided are reactive bifunctional amidites, methods of making these compounds and methods for detecting single nucleotide polymorphisms using the above OTNTPs. Methods for detecting differential gene expression using the OTNTPs and methods of separating specifically modified DNA or RNA using the OTNTPs are also provided.
Patent CA-2500878-A1 (CA)
Title: Cutting guide
Inventor: MARTIN W TED JR
IPC: B23Q9/00
Filed: 2005-03-15
Abstract: A cutting guide for effecting straight accurate cuts along a workpiece includes a clamp, a saw guide pivotally coupled to the clamp and having a guiding edge for bearing support for a portion of the saw so as to guide the saw during the cutting operation of the workpiece, and a cutting template. The cutting template is cuttable so as to produce a template cutting edge on a first template portion and a second discard portion. The template cutting edge identifies the position of the guiding edge relative to a cut line for a specific saw and for a specific angled cut. The cutting template may be used to cut subsequent workpieces having the same cut configuration and using the same saw. A user may have a plurality of cutting templates, each having a different first template portion configuration.
Patent CA-2501977-A1 (CA)
Title: Automated conveyor belt treatment system
Inventor: BRINK CHRISTOPHER
IPC: B65G45/22
Filed: 2003-10-16
Abstract: A treatment system (22) for use with conveyor apparatus (21) that allows for the uninterrupted use of the conveyor apparatus system (21) while simultaneously treating the conveyor belt (15). The system (22) employs of a sump basin (3) and various spray bars (2) that can sanitize, clean or lubricate a conveyor belt (15) in conjunction with the processing of various products. The treatment system (22) allows for the effective reduction of th e down time in the manufacturing possessing using conveyor apparatus.
Patent CA-2502101-A1 (CA)
Title: Lock-in support system for grill
Inventor: WOLLER ROBERT
IPC: A47J37/07
Filed: 2005-03-23
Abstract: The present invention relates to the support mechanism for a grill having a grill bottom, grates for supporting fuel and food, and a cover. The mechanism is detachably attached to the grill without fasteners by projecting pieces that go through holes in the bottom portion or kettle of the grill, some of the projecting pieces supporting the grate for the fuel and other projecting pieces supporting the grate for the food. Only one fastener, for example, a screw with a wing nut, is used to support the mechanism and fasten it to the grill bottom. In a preferred embodiment, the mechanism also has toggle locks to lock together the grill bottom and the cover.
Patent CA-2504549-A1 (CA)
Title: Illumination control apparatus and failure detecting apparatus
Inventor: SATO KAZUHIKO
IPC: B60Q11/00
Filed: 2005-04-12
Abstract: In an illumination control apparatus which drives headlamps in a PWM mode and automatically lights them at low power in a vehicle when the DRL executing condition is held, failure in a PWM-drive switching device and break failure in the lamp are detected as well as the arrangement of control units is optimized and meeting models is facilitated. A relay which switches between lamps and a power source, a CPU which is connected to a CAN and drive-controls the relay for manual lighting, and an integrator circuit which integrates voltage of drive side terminals of the lamps are disposed in a main control unit. An FET which switches between the lamps and the power source, a CPU which drive-controls the FET for automatic lighting, and a power source connecting resister having a resistance value greater enough than that of the lamp that drive side terminals of the lamps are connected to the power source through an ignition switch contact of the vehicle are disposed in a DRL control unit. The CPU determines failure based on the output voltage of the integrator circuit.
Patent CA-2504959-A1 (CA)
Inventor: SCHMIDT EVA
IPC: A61K31/501
Filed: 2003-11-13
Abstract: The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q  and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.
Patent CA-2504991-A1 (CA)
Title: Vehicle floor tray
Inventor: MACNEIL DAVID F
IPC: B60N3/00
Filed: 2005-04-22
Abstract: A vehicle floor tray is molded from a multiple extrusion polymer sheet such that it has high shear and tensile strength, an acceptable degree of stiffness and a high coefficient of friction on its upper surface. The floor tray design is digitally fitted to a foot well of a particular vehicle such that large areas of at least two upstanding walls of the tray depart from respective surfaces of the foot wel l by no more than an eighth of an inch.
Patent CA-2507817-A1 (CA)
Title: Il-21 production in prokaryotic hosts
Inventor: DE JONGH KAREN S
IPC: C07K14/54
Filed: 2003-12-12
Abstract: The expression vectors and methods using an E. coli expression system for th e large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. . Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficie nt E. coli strains transformed with an IL-21 expression vector.
Patent CA-2509996-A1 (CA)
Inventor: TOWNE LLOYD
IPC: F04B43/073
Filed: 2005-06-14
Abstract: A valve apparatus and pneumatically driven diaphragm pump incorporating same having a valve body having a longitudinal axis and an actuator having an axis with a first end and a second end. The first and second ends have first and second diaphragms, respectively, disposed thereon and located transversely to the axis of the actuator. Upon inserting the actuator into the valve body, the first and second diaphragms define wall portions of first and second chambers at the first and second ends of the axis of the actuator, respectively, and a chamber defined between the diaphragms.
Patent CA-2510910-A1 (CA)
Inventor: FONTANA QUENTIN
IPC: F16J15/46
Filed: 2005-06-23
Abstract: A device (10), and also a method, for sealing around an inflatable member (I) at the location of exit (E) of the inflatable member (I) from a body (B), the device (10) being locatable on a body (B) at a position to form a seal around, and to restrain inflation of, the inflatable member (I) at said location of exit (E) thereof from the body (B).
Patent CA-2515156-A1 (CA)
Title: Hazard detection
Inventor: HARVEY ANN M
IPC: G08B29/26
Filed: 2004-02-02
Abstract: In order to allow a smoke detector unit to be utilized in, for example, a domestic kitchen environment, appliances whose operation is commonly associated with the generation of non-hazardous smoke or aerosols are connected to a conventional mains supply socket via a current monitoring unit. The current monitoring units include a radio transceiver, which transmits the operational status of the appliances to a corresponding transceiver of the smoke detector unit 1 . If the signals transmitted by the current monitoring units indicate that the appliances and are off, the smoke detector unit generates a warning signal when the smoke density exceeds a lower threshold. If one of the appliances and is detected to be on, the smoke detector unit generates a warning signal only when a second, higher threshold of smoke density is exceeded. Optionally, when the higher smoke density threshold is exceeded; the smoke detector unit transmits the signal to the current monitoring unit to power off the appliances. The invention is also applicable to the detection of other characteristics of ambient fluid, such as temperature or the presence of a particular gas or vapor.
Patent CA-2516437-A1 (CA)
Inventor: JOHNSON JEFFREY DON
IPC: B64D29/00
Filed: 2004-02-19
Abstract: A honeycomb acoustic unit is provided, the unit comprising first and second honeycomb layers, the layers being made of honeycomb core, each being formed by metallurgical bonds, and a deformable septum having two opposing sides, the first and second honeycomb layers being metallurgically bonded to the two opposing sides of the deformable septum.
Patent CA-2521033-A1 (CA)
Title: Drifting tubing
Inventor: CHURCHILL ANDREW PHILIP
IPC: E21B47/09
Filed: 2004-04-02
Abstract: A method of checking for restrictions in a string of tubing formed of a plurality of tubing sections comprises providing a profile in the tubing string, providing a drift member adapted to engage with the profile, passing the drift member through the tubing string, and determining whether the drif t member has engaged with the profile prior to separating the tubing sections.
Patent CA-2521470-A1 (CA)
Inventor: ENDERWICK THOMAS JEFFREY
IPC: G06F17/30
Filed: 2004-05-26
Abstract: Mechanisms for storing and searching a hierarchy of items are disclosed which may be particularly useful for implementing security policies (312, 314, 319I) and security associations (311, 313, 318), such as, but not limited to Internet Protocol security (IPsec). A hierarchy of items is stored in a search priority order. Multiple element definitions and groups of elements are identified. Representations of the element definitions and elements are stored in a prioritized searchable data structure (310) in decreasing search priority such that representations of each particular element definition is stored after representations of a set of particular elements associated with the particular element definition and before representations of lower priority element definitions and their associated elements. The element definitions may include Internet Protocol security policies (312, 314, 319) and the elements may include Internet Protocol security associations (311, 313, 318). The searchable data structure may include an associative memory or a plurality of associative memory entries.
Patent CA-2524441-A1 (CA)
Title: Treatment of lupus targeting the macrophages or the folate receptor
Inventor: LOW PHILIP STEWART
IPC: A61K51/04
Filed: 2004-05-06
Abstract: The invention relates to a method of treating lupus erythematosus. In one embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate or complex of the general formula L-X where the group L  comprises a ligand capable of binding to activated macrophages or other stimulated immune cells, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function. In another embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate of the general formula L-X where the group L comprises a vitamin, or a vitamin-receptor binding analog or derivative thereof, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function.
Patent CA-2525242-A1 (CA)
Inventor: HAAB GREGOR
IPC: E05F15/60
Filed: 2005-11-03
Abstract: The device has at least one controllable divider element (1) including a drive assembly (2) guided within a track (3), the drive assembly being driven by an electric motor (15) which is controllable by a central control unit (1000) and a local control unit (100), which units exchange data through an electric line (110) located in the track (3) and functioning as the power supply for the electric motor (15). According to the invention, a first direct voltage (u Z1) is provided in the central control unit (1000), the voltage being connectable to the power supply line (110) through a central switch (1004) which is actuated as a function of the data to be transmitted between the central and local control units (1000, 100), whereby, when the switch (1004) is opened, data are able to be transmitted from the local control unit to the central control unit (100; 1000). In addition, an especially advantageous initialization of the device is possible based on the method according to the invention.
Patent CA-2529367-A1 (CA)
Title: Preventing atrial fibrillation (af) with the use of statin drugs
Inventor: NATTEL STANLEY
IPC: A61K31/222
Filed: 2004-06-18
Abstract: The present invention relates to a novel method to prevent or attenuate atrial fibrillation (AF) promotion resulting from atrial tachycardia. In a study conducted with 39 dogs, the HMG-CoA reductase inhibitor simvastatin was found to significantly attenuate AF promotion. This finding constitutes the basis for an interesting new pharmaceutical approach for preventing the consequences of atrial tachycardia remodeling.
Patent CA-2529602-A1 (CA)
Title: Method and apparatus for control channel scheduling in a packet data communication system
Inventor: SMOLINSKE JEFFREY C
IPC: G01R31/08
Filed: 2004-06-24
Abstract: A communication system (200) assigns a combination of values of multiple combinations of values to each of a first and second control channel parameter (for example, PSI1_ REPEAT_PERIOD and BS_ PBCCH_ BLKS). Based on the values assigned to the first and/or second control channel parameters, repeat periods associated with the first, second, and third control messages (P_ 1 and P_ 2, HR_1 and HR_2, and LR_1 to LR_7, respectively) are determined. New combinations of values of the multiple combinations of values are then assigned to the first and second control channel parameters and new first, second, and third control message repeat periods are determined in association with each combination. Optimal first, second, and third control message repeat periods are then selected from among the repeat periods determined with respect to each combination. Based on the selected repeat periods, an optimal combination of values is selected for each of the first and second control channel parameters.
Patent CA-2530728-A1 (CA)
Inventor: TRYGGVASON BJARNI V
IPC: H03M1/12
Filed: 2005-12-16
Abstract: A digital data acquisition system includes a buffer amplifier for receiving an analog signal and attenuating all but those frequencies of interest, a low pass filter, a driver amplifier, an analog to digital converter for converting the analog signal to a digital signal, and a digital signal processor, which is preferably a field programmable gate array incorporating a digital filter and for effecting down sampling of a signal.
Patent CA-2531045-A1 (CA)
Inventor: CHANE-CHING JEAN-YVES
IPC: A61Q11/00
Filed: 2004-06-28
Abstract: L'invention propose des plaquettes de phosphate de calcium individualisées e t dont la longueur est comprise entre 250 nm et 800 nm. L'invention propose également des dispersions contenant les plaquettes selon l'invention ou des dispersions colloïdales obtenues par remise en suspension des dites plaquett es en présence d'un agent dispersant. L'invention concerne aussi un procédé pou r préparer des plaquettes selon l'invention. Enfin l'invention a également pou r objet l'utilisation des plaquettes pré-citées comme charge de renfort, agent de polissage, matériaux de construction, additif pour les formulations bucco - dentaires notamment les dentifrices ou agent d'encapsulation.
Patent CA-2531192-A1 (CA)
Inventor: SMRCEK BRANKO
IPC: E04C2/04
Filed: 2003-07-02
Abstract: The large span buildings comprising no ordinary beams and columns are formed of vertical load-bearing composite wal-panels and composite floors, both comprising two concrete layers interconnected by steel strip webs. The stiff horizontal plane formed of assembled roof/ceiling units, supported by wal-panels, connected to both gables restrains transversal movement of longitudinally arranged wal-panels attached tops, bracing them simultaneously against sideway and lessening their buckling lengths. Floors, if any applied, being rigidly connected to the vertical panels additionally improve stability of the global structure. Hereby invented composite wal-panel and floor are adapted to the same purpose. The global structure, being braced in that way, behaves as a rigid box made of slender panels.
Patent CA-2531225-A1 (CA)
Title: Method for demonstration of a molecular event in a cell by means of fluorescent marker proteins
Inventor: DESSOLIN JEAN
IPC: G01N33/68
Filed: 2004-06-30
Abstract: Process for detecting the occurrence of a particular molecular event in a cell. Process for detecting the occurrence of a particular molecular event in a cell comprises detecting solubilization of a bound protein marker (PM), or binding of a solubilized PM, where PM is a direct or indirect marker of a particular event and is present in the cell before detection. Before detection, the cell is treated to solubilize its plasma membrane so that solubilized protein is released into the extracellular medium and presence of PM is detected, by any suitable method, in the cell or medium so as to determine if solubilization, or binding, and thus the corresponding event, has occurred. Independent claims are also included for the following: (1) PM for use in the new process that comprises a sensitive component (SC), which undergoes solubilization (or binding) and an indicator component (IC) for detection; (2) vector that expresses PM in a cellular environment; (3) transformed cell that expresses PM; (4) non-human transgenic animal in which at least one cell of a certain type expresses PM; and (5) kit for performing the new process that contains cells of (3), the vector of (2) or the animal of (4).
Patent CA-2532382-A1 (CA)
Title: N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
Inventor: COLE DEREK CECIL
IPC: C07D495/04
Filed: 2004-07-23
Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor.
Patent CA-2536235-A1 (CA)
Inventor: VAN DER HOEK CORNELIA
IPC: A61K38/00
Filed: 2004-08-18
Abstract: A new coronavirus, HcoV-NL63, is disclosed herein with a tropism that includes humans. Means and methods are provided for diagnosing subjects (previously) infected with the virus. Also provided are among others vaccines, medicaments, nucleic acids and specific binding members.
Patent CA-2537744-A1 (CA)
Title: Compound and method for enhancing the cholesterol lowering property of plant sterol and stanol esters
Inventor: CARR TIMOTHY P
IPC: A61K31/56
Filed: 2004-09-03
Abstract: The present invention includes a compound which combines, through esterification, the natural cholesterol lowering properties of plant sterols or stanols with the natural cholesterol lowering properties of fatty acids, more particularly a stearic acid. This combination of substances provides a synergistic lowering of cholesterol by interfering with the normal absorption of cholesterol within the gastrointestinal tract of the digestive system and may assist in avoiding unwanted side effects which are typically experienced with commonly used cholesterol lowering drugs.
Patent CA-2539432-A1 (CA)
Title: Altering a b cell pathology using self-derived antigens in conjunction with specific-binding cytoreductive agent
Inventor: GOLD DANIEL P
IPC: C12N1/19
Filed: 2004-09-23
Abstract: A method of treating B cell malignancies or a method for preparing compositions for treating B cell malignancies wherein administration of a specific binding cytoreductive agent is followed by immunization with an autologous Id protein. The two treatments may be sequential, where the administration of the specific binding cytoreductive agent is completed before the administration of the autologous Id protein, or the administration of the specific binding cytoreductive agent and the immunization with an autologous Id protein may occur in an overlapping time course.
Patent CA-2540010-A1 (CA)
Title: Transaction processing architecture
Inventor: PATEL RIKIN S
IPC: G06F40/00
Filed: 2004-09-20
Abstract: Published without an Abstract
Patent CA-2545144-A1 (CA)
Title: Cash dispensing automated banking machine with adjustable chest hinge and method
Inventor: ANTRAM HOWARD
IPC: G06F7/08
Filed: 2004-11-09
Abstract: A secure enclosure for an automated banking machine includes a safe chest portion and a moveable door. The door has mounted thereon a locking bolt work mechanism which is operable to secure the door in a closed position. The door is mounted to the chest with the use of hinge assemblies having respective hinge pins. The hinge assemblies enable the door to be selectively adjusted in up-down and right-left directions. The door can be moved in the up-down direction via an adjustable set screw operative to move vertically relative to a hinge pin. The door can be moved in the right-left direction via adjustable set screws operative to engage and pivot the hinge pin. Thus, the door can be aligned with the chest opening.