baber/WOPTO huggingface dataset:
Patent CA-2421507-A1 (CA)
Title: Screen for glutamate reuptake inhibitors, stimulators, and modulators
Inventor: MACCECCHINI MARIA-LUISA
IPC: G01N33/94
Filed: 2001-08-31
Abstract: Disclosed is a method for identifying compounds that bind to or modulate a glutamate transporter. The disclosed method is useful for identifying compounds that can inhibit, stimulate, or modulate the activity of the glutamate transporter and thus affect glutamate reuptake. The method is a screening technique where compounds known to bind to glutamate receptors (fo r example, glutamate receptor ligands, including many agonists, and antagonist s) are bound to a glutamate transporter and compounds are screened to identify those that can after the binding of the glutamate receptor-binding compounds . Compounds shown to alter the binding of the receptor-binding compounds. Compounds shown to alter the binding of the receptor compounds from glutamat e transporter in the disclosed assay can have a variety of effects on glutamat e transporter in the disclosed assay can have a variety of effects on glutamat e transporter activity including activation or inhibition. These compounds are  expected to affect or interfere with glutamate reuptake by the glutamate transporter and thus can be used to modulate, stimulate, or inhibit glutamat e reuptake. Such compounds are useful to treat various neurological diseases a nd conditions involving glutamate transporter and glutamate receptor activation . One of the compounds is (2S,4R-4-methylgutamate or [3H]-(2S,4R-4- methylglutamate. For example, excess extracellular glutamate is a cause of excessive activation of glutamate receptors. Stimulating glutamate reuptake by glutamate transporter can ameliorate excessive activation of glutamate receptors by reducing the extracellular glutamate concentration. Prodrug for ms of transporter compounds are preferred for use as drugs.
Patent CA-2422326-A1 (CA)
Inventor: HORIUCHI KATSUMI
IPC: B01L3/00
Filed: 2003-03-17
Abstract: ABSTRACT OF THE DISCLOSURE   A swab testing device comprises s container (1) containing a diluent (7), a cap (10, 20) detachably mounted on an opening of the container, an elongating stick (4) secured to or integral with the cap, and a cotton swab (5) connected to a leading end of the stick and immersed in the diluent when the container opening is closed with the cap. The cap provides a communicating channel (12, 14, 27, 31) communicatable with the interior (~) of the container and also communicatable with the atmosphere by an aperture (23a) formed on the cap. The cap also includes a lid (15, 25) by which the aperture may be opened and closed. Any liquid in the container may be discharged through the communicating channel and the aperture, when the lid is opened to communicate the channel with the atmosphere through the aperture, even when the container opening remains closed with the cap.
Patent CA-2422438-A1 (CA)
Title: Communication system for adding data transmission origin information to data
Inventor: SUZUKI HIDEHARU
IPC: H04W12/00
Filed: 2002-07-24
Abstract: A gateway uses (3) the NWMP which is a communication protocol for control da ta in a mobile packet communication network (1), so as to receive mobile statio n data concerning a mobile station (2) from an exchange in the mobile packet communication network (1). The mobile station (2) transmits/receives HTTP da ta to/from a server (5) via the gateway (3) by HTTP. When the HTTP data is transmitted from the mobile station (2) to the server (5), the gateway (3) adds mobile station data concerning the mobile station (2) as an extension header to the HTTP data. This mobile station data added is controlled according to identification data used for performing radio communication connection between the mobile station (2) and the mobile packet communicatio n network (1) and transmitted/received between the exchange and the gateway (3 ) by the NWMP which cannot be used from the mobile station (2). Accordingly, there is no danger of altering the data by the mobile station (2) and a high  reliability can be obtained. As a result, the server (5) can trust the mobil e station data added to the HTTP data and transmitted from the mobile station (2).
Patent CA-2422617-A1 (CA)
Title: Tripeptidyl peptidase inhibitors
Inventor: BRESLIN HENRY JOSEPH
IPC: A61K31/4725
Filed: 2001-10-24
Abstract: The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds. (I) wherein n is an integer (0) or (1); X  represents O; S; or -(CR4R5)m- wherein m is an integer (1) or (2); R4 and R5 are each independently from each other hydrogen or C1-4alkyl; R1 is C1-6alkylcarbonyl optionally substituted with hydroxy; C1-6alkyloxycarbonyl;  aminoC1-6alkylcarbonyl wherein the C1-6alkyl group is optionally substituted with C3-6cycloalkyl; mono- and di(C1-4alkyl)aminoC1-6alkylcarbonyl;  aminocarbonyl substituted with aryl; C1-6alkylcarbonyloxyC1-6alkylcarbonyl; C1-6alkyloxycarbonylaminoC1-6alkylcarbonyl wherein the amino group is optionally substituted with C1-4alkyl; an amino acid; C1-6alkyl substituted with amino;  or arylcarbonyl; R2 is an optionally substituted (5)-membered heterocycle, or R2 is optionally substituted benzimidazole; R3 is a bivalent radical -CH2CH2-optionally substituted with halo or phenylmethyl; or R3 is a bivalent radical of formula (II).
Patent CA-2431624-A1 (CA)
Inventor: WYLIE DOUGLAS H
IPC: E06B9/52
Filed: 2003-06-10
Abstract: A frame for a ventilation screen-frame assembly includes a body having a mounting surface for receiving ventilation screen material. In one example, the body has at least three V-shaped cuts partially through it. Each V-shaped cut leaves an edge of the body uncut. The body is folded about each uncut edge so that the ends of the body meet at a corner. Each V-shaped cut subtends an angle 2 that is slightly less than 90 degrees, so that the folded corners are in compression. The assembly further includes a single corner key for joining the ends of the body into a closed frame. A  reinforcement clip may optionally be provided in each folded corner.
Patent CA-2433786-A1 (CA)
Title: Hollow fiber membrane and method of producing the same
Inventor: MINEGISHI SHIN-ICHI
IPC: B01D61/16
Filed: 2002-09-25
Abstract: A method for producing a hollow fiber film, characterized in that a poly(vinylidene fluoride) type resin solution which comprises a poly(vinylidene fluoride) type resin and a poor solvent for the resin and ha s a temperature of the phase separation temperature thereof or higher is delivered into a cooling bath having a temperature of the phase separation temperature or lower, to thereby coagulate the resin; and a hollow fiber fil m, characterized in that it comprises a poly(vinylidene fluoride) type resin an d has a spherical structure having an average diameter ranging 0.3 to 30 .mu.m . The method allows the production of a hollow fiber film of a poly(vinylidene  fluoride) type resin having high chemical resistance, which exhibits high strength and high water permeability, at a low load to the environment and a t a low production cost.
Patent CA-2434279-A1 (CA)
Inventor: ZELLER BARY L
IPC: A23L27/10
Filed: 2002-01-16
Abstract: A coffee aroma such as a coffee aroma frost is contacted with a volatile organic carrier liquid at a processing temperature at which the carrier is in the liquid state and at which any moisture present is in the form of ice, to effect fixation of the aroma into the carrier liquid. The carrier liquid has a freezing point below the processing temperature, a boiling point above the processing temperature, a vapor pressure of at least 0.01 mm Hg at 25 ~C and atmospheric pressure, and a water solubility of not more than 10 % by weight.
Patent CA-2435148-A1 (CA)
Title: System and method for lock caching for compound atomic operations on shared memory
Inventor: BLAINEY ROBERT J
IPC: G06F13/18
Filed: 2003-07-15
Abstract: A system and method for lock caching for compound atomic operations (i.e. a read or write operation to more than one 4-byte word) on shared memory is provided. In a computer system including a memory shared among a plurality of processing entities, for example, multiple threads, a method of performing compound atomic operations comprises providing a pool of lacks for synchronizing access to the memory;  assigning the locks among the plurality of entities to minimize lock contention; and performing the compound atomic operations using the assigned locks. Each lock may be assigned in accordance with an address of the shared memory from the processing entity's compound atomic operations. Assigning locks may be performed in a manner to minimize concurrent atomic updates to the same or overlapping portions of the shared memory. For example, the addresses of the memory from the compound atomic operations may be aliased in accordance with a known upper bound on the amount of the shared memory that may be affected by any atomic operation.
Patent CA-2437435-A1 (CA)
Inventor: DESARD CHRISTOPHE
IPC: H02G15/013
Filed: 2002-02-04
Abstract: A cable bushing intended to close off, in a sealed way, a space around a plurality of cables, comprises a first compression part (4) intended to be positioned towards the outside of a sleeve (47), a second compression part (6), offset in a longitudinal direction from the first compression part (4) and intended to be positioned toward the inside of the sleeve (47), a plurality of openings (8, 9, 11, 12) formed in the first compression part (4 ) and a plurality of corresponding openings (13, 14, 16, 17) formed in the second compression part (6), each of the said openings (8, 9, 11, 12) in the first compression part (4) being intended, together with the corresponding openings (13, 14, 16, 17) in the second compression part (6) for a respectiv e cable to pass through, sealing means (7) located between the said first compression part (4) and the said second compression part (6), and compressi on means for moving the first compression part (4) and second compression part (6) towards one another in the longitudinal direction to compress the sealin g means (7). The said first compression part (4) and the said second compressi on part (6) each comprise, for each opening (8, 9, 11, 12, 13, 14, 16, 17) therein, at least one piece (19, 21, 22, 23, 24, 26, 27, 28) that is movable to provide access individually to the respective opening (8, 9, 11, 12, 13, 14, 16, 17).
Patent CA-2439005-A1 (CA)
Title: A system and method for performing object association at a tradeshow using a location tracking system
Inventor: DEMPSEY MICHAEL K
IPC: H04W4/029
Filed: 2002-03-11
Abstract: The illustrative embodiment of the present invention provides a method of recording and using object associations determined by a location system at a tradeshow. Object locations are determined based on signals generated from object identifiers (2) attached to the tradeshow attendees and forwarded to an electronic device (12) interfaced with a network (10). The origin of the signal is calculated by a location determining module (14) based on a number of factors such as the known position of he receivers receiving the signal, the historical recorded position of the attendee, the characteristics of the receivers receiving the signal (i.e. the range), the strength of the receive d signal, the type of signal, and whether or not the signal was repeated. Once the location of the attendee has been determined, the location determining module (14) consults a database (18) to determine associations between the located attendee and other persons, objects, exhibits or specified locations based on proximity to the located attendee. Once an association is determine d, it is stored and the duration of the association is subsequently recorded. T he data from the identified associations may then be leveraged in a number of ways as input data for a variety of applications, such as software which generates sales leads and targeted advertising to tradeshow attendees based on their current location.
Patent CA-2440291-A1 (CA)
Title: Method and apparatus for annotating a document with audio comments
Inventor: SPIELBERG STEVEN
IPC: G06F17/24
Filed: 2002-03-07
Abstract: Apparatus and methods allowing users to review and add annotations (512,910) to a digital document (305,306). The document is presented to the user via an audio output device (310) and provides the user with the ability to annotate the document by speaking into an audio input device (310). The user may access the document from multiple locations using multiple types of devices.
Patent CA-2441603-A1 (CA)
Inventor: MCDADE KEITH
IPC: C12Q1/68
Filed: 2002-03-21
Abstract: L'invention concerne un appareil et des méthodes de séquençage d'un acide nucléique. Ces méthodes permettent la réalisation en parallèle d'un nombre très important de réactions de séquençage, avec un séquençage simultané d'un nombre très important (> 10 000) d'oligonucléotides différents.
Patent CA-2442103-A1 (CA)
Title: Prosthetic foot with tunable performance
Inventor: TOWNSEND BARRY W
IPC: A61F2/00
Filed: 2002-03-29
Abstract: A prosthetic foot (70) incorporates a foot keel (71) and a calf shank (72) connected to the foot keel to form an ankle joint area of the prosthetic foot.  The foot keel has forefoot and hindfoot portions and an upwardly arched midfoot portion extending between the forefoot and midfoot portions. The calf shank includes a downward convexly curved lower end which is secured to the foot keel by way of a coupling element (73). The lower end of the calf shank extends upwardly, and initially anteriorly therefore into a reversely curved portion (75) of the calf shank leading to an upstanding upper end thereof.
Patent CA-2442713-A1 (CA)
Title: Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
Inventor: KOZAWA MASAMI
IPC: C07D215/14
Filed: 2002-03-22
Abstract: A method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate represented by the formula [IV]: [IV] wherein R represents an alkyl group or an aryl group, characterized in that a compound represented by the formula [I]: [I] wherein R is as defined above, or a compound represented by the formula [II]: [II] wherein R is as defined above is reduced by sodium borohydride in the presen ce of a boron compound represented by the formula [III]: [III] wherein R' and R " represent independently an alkyl group, and then the resultant reaction mixture is treated with an aqueous solution of hydrogen peroxide. The method can be employed for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate usefu l as an intermediate of an medicine with high purity in high yield.
Patent CA-2443199-A1 (CA)
Inventor: STELLEMA CORNELIS SJOUKE
IPC: A23D7/02
Filed: 2001-10-22
Abstract: Edible W/O-emulsion spread of which the fat phase comprises a vegetable hardstock fat, which hardstock fat contains at least 5 wt.% of Allanblackia fat and/or Pentadesma fat and which preferably contains at least 45 wt. % of SOS triglycerides (S denotes a fatty acid residue with a saturated C18-C24 carbon chain and O denotes an oleic acid residue).
Patent CA-2444637-A1 (CA)
Title: Composes, compositions pharmaceutiques et procedes pour le traitement de bacteriemie et/ou septicemie
Inventor: OFEK ITZHAK
IPC: C07K7/62
Filed: 2002-01-16
Abstract: L'invention concerne de nouveaux conjugats de peptides de liaison à la membrane extérieure d'une bactérie présentant, de préférence, une activité de sensibilisation bactérienne. L'invention traite aussi de peptides chimiotactiques de cellules immunitaires, et de compositions pharmaceutiques contenant ces composés et permettant de traiter la bactériémie, et/ou la septicémie suivant une infection par des bactéries gram négatives lors de leur administration seules ou en association avec des antibiotiques traditionnels.
Patent CA-2445565-A1 (CA)
Title: Compositions and methods of double-targeting virus infections and cancer cells
Inventor: KUCERA LOUIS S
IPC: A61P25/28
Filed: 2002-04-26
Abstract: The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting th e virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions of the invention include compounds, whic h comprise a phosphocholine moiety covalently conjugated with one or more therapeutic agents (e.g. nucleoside analogue, protease inhibitor, etc.) to a lipid backbone. The invention also includes pharmaceutical compositions for use in treatment of a virus infection in mammals. The methods of the inventi on comprise administering a compound of the invention, a pharmaceutically acceptable salt or a prodrug thereof, or a pharmaceutical composition of the invention, in an amount effective to treat the infection, to a mammal infect ed with a virus. Additionally, the invention includes compositions and methods useful for combating a cancer in a mammal and facilitating delivery of a therapeutic agent to a mammalian cell. The compositions of the invention include compounds, which comprise an alkyl lipid or phospholipid moiety covalently conjugated with a therapeutic agent (e.g., a nucleoside analogue) . The invention also includes pharmaceutical compositions for combating cancer and facilitating delivery of a therapeutic agent to a mammalian cell. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt or a prodrug thereof, or a pharmaceutical composition of the invention, in an amount effective to combat a cancer or t o facilitate delivery of a therapeutic agent to a mammalian cell.
Patent CA-2447552-A1 (CA)
Title: Blunt faced cutter element and enhanced drill bit and cutting structure
Inventor: SINGH AMARDEEP
IPC: E21B10/52
Filed: 2003-10-31
Abstract: A cutter element is disclosed having a rounded apex offset from the center line of the insert and having a relatively broad and blunt front face and a narrower, more rounded rear face. The cutter element may be disposed in the outermost inner row of a rolling cone cutter of a bit with the broader front face facing the borehole side wall so as to resist off center wear and resultant bit whirl. When placed in inner rows and oriented with the broader and flatter front face being the first portion of the cutting surface to engage the borehole, enhancements in bit durability may be achieved, particularly when drilling through formations of multiple hardness.
Patent CA-2447681-A1 (CA)
Title: Vanadium redox battery electrolyte
Inventor: SKYLLAS-KAZACOS MARIA
IPC: H01M8/08
Filed: 2002-05-17
Abstract: The present invention relates generally to the production of a vanadium electrolyte, including a mixture of trivalent and tetravalent vanadium ions in a sulphuric acid solution, by the reactive dissolution of vanadium trioxide and vanadium pentoxide powders, the surface area and particle size characteristics being controlled for complete reaction to produce the desire d ratio of V(III) to V(IV) ions in the solution. The solution may be suitable for direct use in the vanadium redox battery, or the solution can provide an electrolyte concentrate or slurry which can be reconstituted by the addition of water or sulphuric acid prior to use in the vanadium redox battery.</SDOA B>
Patent CA-2448452-A1 (CA)
Inventor: YIN JIA HONG
IPC: G07C9/00
Filed: 2002-05-23
Abstract: This invention provides a system for automatically classifying and counting people, such as supermarket customers, and associated objects such as shopping trolleys; a principal objective being to provide operators of such establishments with the ability to automatically differentiate between certain predetermined categories of customer, thus permitting correlation between customer categories and their respective shopping habits. Typical categories include customers using (or not using) trolleys; those shopping alone or in groups; those with children; children alone and male and female customers. The invention uses one or more video cameras to view an area traversed by the customers and processes the video data, in real time, to allocate each customer to one or more of the predetermined categories in dependence upon recognition criteria developed to permit reliable classification of customers in relation to the various categories.
Patent CA-2449765-A1 (CA)
Title: Compressor discharge valve retainer
Inventor: MONNIN MICHAEL J
IPC: F04B39/00
Filed: 2003-11-18
Abstract: A discharge valve retainer is manufactured from powder metal using FLC4608, FL4405, FC0205 or FC0208 material. The finisher retainer has a density of approximately 6.8 to 7.6 gm/cc. The retainer is carbonitrided, quenched and tempered to achieve a surface hardness of Rockwell 15N 89-93. The exterior of the retainer is contoured to provide for the non-turbulent flow of pressurized gas around the discharge valve.
Patent CA-2451845-A1 (CA)
Inventor: TAOLIN YI
IPC: A61K31/39
Filed: 2002-05-31
Abstract: Dans plusieurs modes de réalisation, la présente invention concerne des antimoniés pentavalents, des antimoniés pentavalents purifiés et des antimoniés pentavalents constitués d'une partie antimoniée et d'une partie de fraction organique. Dans un autre mode de réalisation, la présente invention concerne des agents et des méthodes de criblage d'agents simulant l'activité des antimoniés pentavalents, et notamment du stibogluconate de sodium et de la glucantime. Une fraction organique appropriée peut être sélectionnée sur la base d'une interaction (telle qu'une action stérique) avec le site actif d'un constituant cellulaire (tel qu'une PTPase). Dans un mode de réalisation préféré de la présente invention, le site actif comprend un résidu de cystéine pouvant subir l'effet des compositions de la présente invention.
Patent CA-2454680-A1 (CA)
Title: Fuel cell system having a hydrogen sensor
Inventor: WELLS BRIAN
IPC: H01M8/04
Filed: 2002-07-25
Abstract: An electric power generating system is provided that comprises a fuel cell stack (12) having at least one solid polymer fuel cell, a cooling system (82 ) having a coolant flow path that directs coolant to and from the stack, a fue l regulating system (54) having a fuel flow path and for regulating the supply of fuel from a fuel supply (52) to the stack via the fuel flow path, and a hydrogen concentration sensor(55). The sensor is located in the vicinity of the fuel regulating system and in the coolant flow path at a location downstream of the stack to detect hydrogen that may have been discharged by components of the power generating system in the coolant flow path upstream of the sensor, or by the fuel regulating system. In the event the measured hydrogen concentration exceeds a threshold level, steps are taken to reduce or stop the discharge of hydrogen from the power generating system.
Patent CA-2456043-A1 (CA)
Inventor: BELLON CANEIRO JUAN MANUEL
IPC: A61F2/00
Filed: 2002-07-31
Abstract: The invention relates to a prosthesis that can be implanted in the centre of wall wound scarring. The inventive prosthesis, which is intended for use in abdominal surgery, is provided with a geometric shape in the form of sheets that converge in dihedral angles. The sheets or planes are made from a synthetic biotolerated material in porous form with large pores. One of said planes is inserted into the centre of the scarring between the two aponeurot ic surfaces to be joined. The other plane(s) of the prosthesis, which is perpendicular to the aforementioned plane, is arranged so as to overlap the aponeurotic edges of the edge of the section. The proliferation obtained around the prosthesis, in the scarring centre and close thereto, provides stress resistance greater than that obtained in standard closures, thereby greatly reducing the risk of hernias caused by a badly healed wound.