baber/WOPTO huggingface dataset:
Patent JP-H11503825-A (JP)
Title: 感染または病原性の阻害に有用な化合物のスクリーニング法
IPC: C12N15/09
Filed: 1996-03-27
Abstract: (57)【要約】
感染または病原性の阻害に有用な化合物を同定するためのスクリーニング方法が開示される。また、病原体毒性因子を同定するための方法も開示される。
Patent JP-H10500485-A (JP)
Title: サイトカインモジュレーターのスクリーニング
IPC: C12Q1/6897
Filed: 1995-05-15
Abstract: (57)【要約】
本発明は、サイトカインにより影響される疾患および病理学的状態の処置に有用である薬剤のスクリーニング法を提供する。これらの薬剤は直接または間接的に細胞内受容体（順次ｒｅｌ様タンパク質、ｒｅｌ様タンパク質複合体またはサイトカイン遺伝子のプロモーター上のｒｅｌ部位に対する他の転写タンパク質の結合を調節する）と相互作用する。該細胞内受容体はエストロゲン受容体、レチノイド酸受容体、レチノイドＸ受容体、グルココルチコイド受容体、プロゲステロン受容体、アンドロゲン受容体、甲状腺ホルモン受容体またはビタミンＤ受容体であってよい。選択した薬剤は、骨粗鬆症、慢性関節リウマチ、炎症、乾癬、カポジ肉腫、敗血症性ショックおよび多発性骨髄腫の治療に使用することができる。
Patent JP-2000507542-A (JP)
IPC: A61P25/16
Filed: 1997-02-27
Abstract: The present invention relates to the use of compounds of general formula wherein R1 is hydrogen, halogen, lower alkyl or lower alkoxy; R2 is hydrogen; R3 is hydrogen, amino, ureido, lower alkylcarbonyl, lower alkyl-sulfonylamino, lower alkylcarbamoyl, carbamoyl, lower alkyloxycarbamoyl, lower alkylamino or R2 and R3 taken together are -(CH2)m-X is methylene, hydroxymethylene, lower alkoxymethylene or carbonyl, n is 0, 1 or 2 and m is 3 or 4 as well as pharmaceutically acceptable salts for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.
Patent JP-2002509505-A (JP)
Title: 流体分配容器用の閉鎖可能な注入スパウト
IPC: B65D47/06
Filed: 1996-04-08
Abstract: (57)【要約】
注入スパウト（４０）は、容器（４２）から入れ物へ流体を導く。注入スパウト（４０）は、導管部材（４４）を備えており、この導管部材は、容器（４２）に接続可能な第１の端部と、排出開口（５０）及び通気開口（５２）を有する第２の端部とを備えている。注入スパウトは、また、排出開口（５０）に隣接して設けられる蓋部材（４８）を備えている。蓋部材（４８）は、排出開口（５０）及び通気開口（５２）が閉じられる第１の位置と排出開口（５０）が開かれる第２の位置との間で、導管部材（４４）に対して相対的に運動可能である。蓋ロック装置（６２、８２）が、蓋部材（４８）が第１の位置から第３の位置へ動く間に第２の位置がバイパスされるのを阻止する。通気ロック装置（８４、８６、９０、９２、９４）が、容器（４２）が所定の角度を超えて傾斜している時に、蓋部材（４８）が第１の位置から第２の位置へ移動するのを阻止する。別の装置（１１６、１２２、１２４）が、蓋部材（４８）が第２の位置にある時に、容器（４２）の中の圧力を周囲圧力以下に維持する。
Patent JP-H11504540-A (JP)
Title: 超音波トランスデューサ方位検出表示装置および方法
IPC: A61B8/12
Filed: 1996-04-30
Abstract: (57)【要約】
超音波トランスデューサの撮像平面の方位の正確な表現を提供するのに使用される、超音波トランスデューサの方位検出および表示の装置、および関連する方法。この方位検出表示装置は、欠くことのできない方位センサとプロセッサとディスプレイを有する超音波トランスデューサを含む。ディスプレイ上に指示される撮像平面の表現は、方位センサにより生成される電気信号に基づく。この発明の一実施例によれば、超音波トランスデューサは、超音波撮像に使用される腹腔鏡器械の延長管の末端、すなわち先端に近く組み込まれている。方位センサは二軸重力センサであって、水平面内に横たわる全ての軸の周りの回転を検出する二つの直交した検出トロイドから構成される。各検出トロイドは中空の管の形を有し、トロイドの中心を通る軸の周りの回転を検出するために、それぞれの検出トロイド内を自由に移動する重力指示体を含んでいる。重力が各重力指示体をそれぞれのトロイドの最低部分へ移動させる。方位は永久磁石を含むこともでき、こうして三軸センサが提供される。
Patent JP-2000510231-A (JP)
Title: 空気汚染物質モニター装置
IPC: G01N31/00
Filed: 1997-03-26
Abstract: (57)【要約】
空気汚染物質モニター装置は、航空機のエンジン排出空気口のような空気源に接続可能な試料用ヒーターを含む。ヒーターは試料空気中のオイル、その他の炭化水素を全てＣＯ 2 とＨ 2 Ｏに分解させる。真空ポンプが加熱された空気の試料をヒーターから二酸化炭素分析装置へと引き抜く。分析装置の応答が帯記録紙又はペーパーレス記録装置により記録される。
Patent JP-2001515375-A (JP)
Title: 血管内血液ポンプ
IPC: A61M60/135
Filed: 1997-04-02
Abstract: (57)【要約】
本明細書で提示する血管内血液ポンプは、駆動ユニット（１１）、およびそれに緊密に接続されたポンプ・ユニット（１２）を有し、血液ポンプはカテーテル（１３）に接続され、それを血管（１０）に挿入できるようにする。ポンブ・ユニット（１２）の管状ケーシング（１５）には、吸引側（２１）を放出側から分離し、したがってポンプが迂回されるのを防止する遮断装置（２０）が取り付けられる。
Patent JP-2001513676-A (JP)
Title: 血液パラメータ測定装置
IPC: A61B5/1459
Filed: 1997-07-14
Abstract: (57)【要約】
特に外科的処置に有用な血液パラメータ測定装置（１４）は、ハウジング内に収容された少なくとも１つの光源（２１２）と、光検出器（２１４）と、信号変換器（４３８，４３９，  ４４０）とを有するコンパクトなハウジング（２００）を含む。使用時、装置（１４）はカセット（１２）に解放自在に結合され、このカセットは心肺バイパス回路と直列のインラインセルとして、または心肺バイパス回路を切り換える他の通路で使用することができる。好ましくは、装置（１４）のハウジング（２００）は、カセット（１２）を通して流れる血流方向に対し概して平行方向に延在する長手軸線を有する。
Patent JP-2001515417-A (JP)
Title: ゲームボールやゴルフボール用などの紫外線照射硬化性インク
IPC: C09D11/10
Filed: 1998-02-23
Abstract: (57)【要約】
ゲームボール、ゴルフボール等に対するインクの紫外線硬化が開示される。製造インク、ロゴインク及びゴルフボール、ゲームボール等に製造プリントやロゴを形成する方法が開示される。紫外線硬化性水不溶性製造インクを形成するために、少なくとも付着促進成分がインクベースに添加される。該付着促進成分は、カルボン酸官能性モノマー、カルボン酸官能性オリゴマー、エステル官能性モノマー、エステル官能性オリゴマー及びその混合物からなる群より選ばれ、該付着促進成分１モルあたり少なくとも約２モルのカルボニル官能性を含み、紫外線硬化後及び該製造インクをトップコートで被覆した後にトップコート及びゲームボール又はゴルフボールの表面に対して少なくとも約75％のインク表面の該製造インクの付着を十分維持するものである。紫外線硬化性水不溶性ロゴインクを形成するために、少なくとも強靭剤がインクベースに添加される。該強靭剤は、紫外線硬化後に少なくとも約75％のインク表面のトップコートに対する該ロゴインクの付着を十分維持するものである。
Patent JP-2001500526-A (JP)
IPC: A61K31/425
Filed: 1998-02-24
Abstract: This invention relates to the use of 2-methyl-thiazolidine-2,4-dicarboxylic acid and/or its physiologically tolerable salts as mucolytic agents.
Patent JP-2000510724-A (JP)
IPC: A61F7/00
Filed: 1997-05-16
Abstract: A cooling system for cooling a person in a supine position as part of a clinical treatment includes an air blower, a heat exchanger, an inflatable mattress and a cooling jacket or overlay. Air from the blower is cooled by contact with the heat exchanger, passed through the jacket or overlay and through the mattress in order to rapidly cool the person so as to achieve mild hypothermia.
Patent JP-2001516469-A (JP)
IPC: G02B6/10
Filed: 1998-03-26
Abstract: One or more photonic crystals 11, 22, 40, 58, 59 are formed directly in the path of light within an optical fiber 13, 23, 42, 56. Light processed by the photonic crystal may be transmitted out of the fiber by means of a lens 48 or it may be measured by a photoresistive device 51, 60. The photonic crystal may be formed in a trench 12 as an array of dielectric rods 16 having one or more selective defects 17, or the crystal may be formed by providing holes 20 directly in the optical fiber. Filling the interstices between rods 16 with non-linear optical material, and subjecting the crystal to a varying electric field applied by electrodes or to a varying optical radiation can produce a tunable photonic crystal within an optical fiber.
Patent JP-H11511784-A (JP)
Title: 悪臭除去のためのα―アミラーゼ類の組み合わせを含む洗剤組成物
IPC: C11D3/386
Filed: 1997-05-13
Abstract: (57)【要約】
硬質面クリーニング、皿洗いおよびランドリー用途における汚れ物品から生ずる悪臭除去の改善を果たすための、異なったα−アミラーゼ類の組み合わせを含有させた洗剤組成物の提供。
Patent JP-2001524094-A (JP)
IPC: A61K47/36
Filed: 1998-04-20
Abstract: Liquid pharmaceutical compositions for administration to a mucosal surface, including a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or can be adapted to gel, at the site of application in the absence of an extraneous source of divalent metal ions.
Patent JP-2001522441-A (JP)
IPC: F16D65/14
Filed: 1998-04-27
Abstract: An adjuster assembly for compensating for brake lining wear in a brake unit. The brake unit has a housing for accommodating the adjuster assembly, a brake lever journalled to the housing, and a force transmitter for transmitting displacement of the brake lever to at least one brake lining. The adjuster assembly includes a support shaft, sensing means for cooperation with the brake lever, a drive ring assembly cooperating with the sensor, and an adjuster gear. The adjuster gear cooperates with the drive ring assembly. To prevent unwanted release of the adjuster assembly, the engagement surface is provided with rotation a rotation preventer adapted for releasable engagement with engagement member cooperating with the housing for preventing rotation of the transmission ring assembly in one direction.
Patent JP-2002512649-A (JP)
Title: ガス分離による炭化水素合成触媒スラリーの再生方法
IPC: B01J38/58
Filed: 1998-04-29
Abstract: (57)【要約】
スラリー炭化水素合成スラリー中の可逆的に不活性化された微粒子触媒が、スラリー本体からのスラリーを(i)スラリーから気泡を除去するガス分離域、(ii)触媒再生ガスがスラリー中の触媒と接触して、それを再生し、再生された触媒スラリーを形成する触媒再生域を通じて循環させ、(iii)スラリー本体に戻すことにより再生される。少なくとも一部の気泡を除去することで再生方法を改善する。
Patent JP-2000506473-A (JP)
IPC: B61F19/04
Filed: 1998-04-29
Abstract: A railway vehicle has, located centrally on the end of a car body 1, a coupling device and at least one shock absorbing device 9, 10, which has a permanently deformable support element. To achieve an effective protection against under-running in an impact the, individual shock absorbing elements 9, 10 are parallel to one another underneath a horizontal plane that contains a coupling device 4.
Patent JP-2001525839-A (JP)
Title: 炭素環式ヌクレオシド１５９２ｕ８９を含有する抗ウイルス的組合せ
IPC: A61K31/55
Filed: 1998-05-14
Abstract: (57)【要約】
本発明は、抗ＨＩＶ活性を有する（−）−（１Ｓ，４Ｒ）−４−［２−アミノ−６−（シクロプロピルアミノ）−９Ｈ−プリン−９−イル］−２−シクロペンテン−１−メタノール（１５９２Ｕ８９）と非ヌクレオシド逆転写酵素阻害剤（ＮＮＲＴＩｓ）の治療上の組合せ物に関する。本発明は、また、これらの組合せを含有する治療用組成物、ならびにヌクレオシドおよび／または非ヌクレオシド阻害剤に耐性を有するＨＩＶ変異体の感染を含むＨＩＶ感染の治療におけるそれらの使用に関する。
Patent JP-2001526680-A (JP)
IPC: C11D3/20
Filed: 1997-05-19
Abstract: The present invention relates to biodegradable softener compounds of the formula (1): [(R)4-m-N(+)-[(CH2)n-Y-R1]m]X(-) with an acid value of no more than 6.5. A process for making said compound is also provided. The softener can be incorporated into softener compositions to form solid and liquid compositions, including liquid dispersions and clear compositions.
Patent MD-20060265-A (MD)
Title: Method of verifying the origin of goods
Inventor: BELOUSOV VLADIMIR
IPC: H03M13/00
Filed: 2006-11-29
Abstract: The method of verifying the origin of goods consists in that each unit of goods is assigned an individual code representing a set of letters, numbers and characters which is introduced into the accompanying forms of the given unit of goods, at the same time a part of the code remains free for viewing and another part is protected by a unviewed cover, destructible under the mechanical action upon it. Concomitantly the integral code is introduced onto the site of the producer of goods and later on, by its setting via Internet, the consumer receives the signal about the authenticity of the given specimen of goods, afterwards, according to the program, the used code is deleted from the site of the producer of goods. If by chance the code indicated in the accompanying forms and the one setted by the consumer do not find an analogue onto the site of the producer of goods, this testifies to the counterfeit of goods.
Patent NZ-205392-A (NZ)
Title: Preparation of immunoglobulins against e.coli pili
Inventor: LINGGOOD M A
IPC: A23C9/20
Filed: 1983-08-26
Abstract: Antibodies are produced by hyperimmunising a mammal, such as a cow, with a vaccine derived from E. coli bacteria. The bacterial strains in the vaccine are selected on the basis of their virulence characteristics, especially adhesion factors (pili), associated with gastroenteric disease in humans. The antibodies can be recovered from the mammal's milk or serum, and used in human foods.
Patent NZ-206753-A (NZ)
Title: Pharmaceutical compositions containing sulphite,bisulphite,or cyclic sulphite esters of alcohols
Inventor: MARTIN B K
IPC: A61K31/255
Filed: 1984-01-05
Abstract: Hypertension and thrombotic conditions in mammals are treated by administration of sulphite, bisulphite or cyclic sulphite ester of a monohydric or polyhydric alcohol.
Patent NZ-222450-A (NZ)
Title: Synthetic dna, peptide synthesis and regulation of transcription of silk like protein
Inventor: FERRARI FRANCO A
IPC: C12N15/11
Filed: 1987-11-04
Abstract: Methods for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and tranlational regions to control the production of the large polypeptides are also provided.
Patent NZ-228744-A (NZ)
Title: Settling vessel for separating activated sludge from sewage
Inventor: TURGAY HUDAI
IPC: B01D21/06
Filed: 1989-04-14
Abstract: A separation vessel for the separation of activated sludge from a waste water/activated-sludge suspension is provided in the centre with a pipe (7) open at the top and closed at the bottom by a base (9), into which pipe, in the vicinity of the base (9), an inlet (10) joined to the feed line (11) for the suspension opens. The central pipe (7) is surrounded at a distance by a second pipe (8) which is open at both ends, terminates beneath the liquid surface (20) and projects above the liquid surface (20) at the other end, as does the central pipe (7). The central pipe (7) is provided with a stirrer, the variable speed of rotation of which is adjusted to such a value that the suspension in the upper part of the pipe (7) forms a parabola of rotation which extends up to the edge and from which the suspension emerges over the edge. 
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Patent NZ-243504-A (NZ)
Title: Raisable assembly of stalls with gates for milking shed
Inventor: LARSEN OWEN MAXWELL
IPC: A01K1/00
Filed: 1992-07-09
Abstract: PCT No. PCT/AU92/00335 Sec. 371 Date Mar. 4, 1994 Sec. 102(e) Date Mar. 4, 1994 PCT Filed Jul. 9, 1992 PCT Pub. No. WO93/00798 PCT Pub. Date Jan. 21, 1993.A mechanism for the control of cows within a milking shed that includes a plurality of dividers mounted so as to be movable from a first or raised position, whereupon cows can move beneath the dividers, to a second or lower position where the dividers are capable of preventing movement by the cows. The dividers are spaced apart so as to provide a plurality of milking stalls. Each of the dividers has an outer end, an inner end, an upper rail, a lower rail, and a plurality of vertical rails connecting the upper rail to the lower rail. Each outer end has pivotally mounted thereto an end gate pivotable between a transverse position and a position approximately co-planar with the dividers by movement of a cow into the stall immediately past the divider. Each divider is pivotally mounted to a milking shed wall and the lower rail is inclined upwardly at the inner end of each divider and joins the upper rail at the wall pivotal mounting.
Patent NZ-246593-A (NZ)
Title: Amidine derivatives; their preparation and medicaments containing them
Inventor: ANDERSKEWITZ RALF
IPC: A61P11/06
Filed: 1993-01-14
Abstract: Amidine derivs. of formula (I), in the form of their racemates, enantiomer pure or enriched forms, diastereomer pairs, cis- and trans-isomers, free bases or salts (pref. with physiologically acceptable acids) are new. In (I), R1 and R2 are each CF3, halogen, R5, OR5, COR6, SR6, SOR6, SO2R6, SO2NR5R7, C(OH)R5R7, or R1 and R2 connect neighbouring C atoms on the benzene ring to which they are attached with -CR8=CR9CH=CH-, -CH=CR8CR9=CH-, -CR8=CHCR9=CH-, -OCHR10CH2-, -OCH2O-, -OCH2CH2O-, -(CH2)3-4-, -NHCOO-, -NHCOCH2O-, -COCH2O- or -COCH2CH2O-, each of these gps. being opt. substd. with 1-4C alkyl; R3 is H, OH, CF3, R5, OR6, COR6, CONR5R7, CH2OH, CH2O(1-4C alkyl), SR6, SOR6, SO2R6, SO2NR5R7, NHCO(1-4C alkyl), NHSO2(1-4C alkyl), NR5R7 or C(OH)R5R7 or a heterocyclic 5-ring contg. 1-3 heteroatoms and of formulae (a), (b) or (c); provided that if R3 is R5, R5 can only be H if at least one of R1 and R2 is not H; D, E and G are each CH, N, C(1-4C alkyl) or C-Ph; L is O or S; R4 is halogen, NH2, NH(1-4C alkyl), N(1-4C alkyl)2, OH, 1-4C alkoxy; R5 is H, 1-12C alkyl, phenyl(1-4C)alkyl or Ph (opt. substd. with halogen, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); R6 is 1-12C alkyl, Ph (opt. substd. with halogen, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); R7 is H or 1-12C alkyl; R8 and R9 are each H, OH, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl; R10 is H or 1-4C alkyl; R11 and R12 are each H, OH, halogen, CF3, 1-4C alkyl or 1-4C alkoxy; A is (d), (e), X1A1X2, X2A2X3, X4A2X2, (CH2)1-2NHCO(CH2)1-3X2, -CH=CHA2X2; B is CH=CH, CH=N, S or (f); A1 is 2-4C alkylene, cis- or trans-CH2CH=CHCH2, CH2CCCH2, etc.; A2 is 1-5C alkylene; X1 is O, NH, S, SO, SO2, CO, CH2 or a gp. of formula (d); X2 is O, NH, S or a gp. of formula (e); X3 is NHCO, CONH, SO2NH or a gp. of formula (d); X4 is NHCO, CONH, NHSO2, SO2NH or NHCONH.
Patent NZ-255620-A (NZ)
Title: Reduction of chloride content in pulping liquor recycling
Inventor: LINDBERG HANS
IPC: D21C11/06
Filed: 1993-08-18
Abstract: PCT No. PCT/SE93/00688 Sec. 371 Date Feb. 23, 1995 Sec. 102(e) Date Feb. 23, 1995 PCT Filed Aug. 18, 1993 PCT Pub. No. WO94/04747 PCT Pub. Date Mar. 3, 1994The present invention relates to an environmental-friendly process for reducing the content of chloride in a liquor inventory of a chemical pulp mill. According to the invention, in a recovery system for pulping chemicals containing sulphur and an alkali metal, precipitator dust formed in a recovery boiler is collected and withdrawn, dissolved in water and electrolyzed for production of chlorine or hydrochloric acid in the anolyte. Since the dust normally contains a large amount of sodium sulphate, sulphuric acid and sodium hydroxide can also be produced in the electrolysis. To reduce the content of impurities, before the electrolysis, the pH of the aqueous solution is adjusted to above about 10 to precipitate inorganic substances which are separated-off together with flocculated or undissolved substances.
Patent NZ-276644-A (NZ)
Title: Polymeric compositions containing a heat distortion resistant polymer, a radio-frequency susceptible polymer and a compatibilising polymer
Inventor: LAURIN DEAN
IPC: C08L23/02
Filed: 1994-11-16
Abstract: A polymer based composition for fabricating into articles is described. The composition comprises:   a polypropylene in an amount by weight from 40-90% of the composition and having a melting temperature greater than 130 DEG C; a radio frequency susceptible polymer in an amount by weight from 5-50% of the composition and having a dielectric loss greater than 0.05 at 1-60 MHz and ambient temperature to 250 DEG C, the susceptible polymer being selected from (1) polymers containing at least one segment selected from the group consisting of urethanes, esters, ureas, imides, sulfones, and amides, and (2) ethylene copolymers having 50-85% ethylene content copolymerized with at least one monomer selected from the group consisting of acrylic acid, methacrylic acid, ester derivatives of acrylic acid with alcohols having 1-10 carbons, vinyl acetate, and vinyl alcohol; a compatibilizing polymer in an amount by weight from 5-30% of the composition, the compatibilizing polymer conferring compatibility between the radio frequency susceptible polymer, and the polypropylene, the compatibilizing polymer being a styrenic block copolymer with hydrocarbon soft segments, and wherein the composition has an optical haze value of less than 30% for the composition processed into a film of about 0.299 mm in thickness measured in accordance to ASTM D-1003, a mechanical modulus of less than 2758x10<5> Pa when measured according to ASTM D-882 and the composition exhibits no strain whitening after being strained at moderate speeds of about 50 cm per minute to about 100% elongation.
Patent NZ-292822-A (NZ)
Title: Corneal correction template with a water jet micro-keratome cutter for refractive vision correction
Inventor: GORDON EUGENE IRVING
IPC: A61B17/30
Filed: 1995-09-12
Abstract: The device disclosed below is for  use in a method for the selective, accurate removal of layers of corneal tissue, and change of curvature thereof, for refractive vision correction of an eye. The device comprises: a) a template adapted specifically to be placed and centered on the anterior portion of the corneal tissue to be removed; b) a vacuum suction means and c) a means to align the water jet with the planar surface for the cutting thereof. The template comprises a surface therein to which the anterior portion, to be removed, is adapted to be fitted and deformed by such fitting.  The deformation is predeterminately controlled so that the surface to be cut, at the base of the anterior portion assumes a planar configuration, which is accessible for the cutting thereof, beyond an end of the template.  The anterior portion is defined between anterior and posterior surfaces.  The surface of the template has a height relative to a plane at the end of the template equal to the computed difference, point by point, of the difference in height between the anterior and posterior surfaces of the portion of the corneal tissue, which is to be removed. The vacuum suction means is adapted to create a suction between the surface and the anterior portion.  The cutting means comprises a micro-keratome comprised of a high speed water jet, having a planar sheet configuration, and being formed with a pressure between 3000 to 20000 psi. The aligning means comprises a ring member supporting the water jet, with the ring member comprises means for being affixed in aligned relation with the template.
Patent NZ-315971-A (NZ)
Title: Indazolecarboxamide derivatives
Inventor: CATLOW JOHN THOMAS
IPC: A61K31/4427
Filed: 1996-03-14
Abstract: Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT4 receptor. The indazolecarboxamides are of the formula <CHEM>  wherein:   R   is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl; R<1>   is hydrogen, halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy or alkylthio, cyano, trifluoromethyl, carboxamido, mono- or di(C1-C4 alkyl)carboxamido; m, n and o   are independently 0-5, provided that the sum of m, n and o is 2-5; R<2>   is hydrogen or C1-C4 alkyl; R<3> and R<4>   combine with the nitrogen atom to which they are attached to form 1-pyrrolidinyl, 1-piperazinyl, 1,2,3,4-tetrahydro-2-isoquinolinyl, 2,3-dihydro-1-indolinyl, 4-morpholinyl, 1-piperidinyl or 1-hexamethyleneiminyl, substituted with phenyl, naphthyl, (phenyl or naphthyl) (C1-C3 alkyl), (phenyl or naphthyl) (C1-C3 alkanoyl), amino, mono- or di(C1-C4 alkyl)amino, or a group of the formula -NH-Y-R<5>; provided that a piperazinyl or morpholinyl group may not be substituted with amino, mono- or di(C1-C4 alkyl)amino, or -NH-Y-R<5>; wherein a phenyl or naphthyl group is unsubstituted or substituted with 1-3 halo, C1-C3 alkyl or C1-C3 alkoxy groups; Y   is carbonyl, sulfonyl, aminocarbonyl or oxycarbonyl; R<5>   is C1-C6 alkyl, C3-C8 cycloalkyl, C6-C11 bicyclo- or tricycloalkyl, (phenyl or naphthyl)(C1-C3 alkyl), phenyl or naphthyl; wherein a cycloalkyl, bicyclo- or tricycloalkyl, phenyl or naphthyl group is unsubstituted or substituted with 1-3 hydroxy, halo, C1-C3 alkyl or C1-C3 alkoxy groups; or a pharmaceutically acceptable salt thereof.
Patent NZ-331921-A (NZ)
Title: Computerized quotation system and method
Inventor: GIOVANNOLI JOSEPH
IPC: G06Q30/08
Filed: 1997-02-21
Abstract: A computerized system for forming a computer based communications network of network members inclusive of network buyers and or network vendors for processing requests for quotation for goods and services through at least one central processing unit including operating system software for controlling the central processing unit, storage means containing the identification of network members, means for network buyers to generate request for quotation for goods and/or services, means for transmitting said request for quotation to said central processing unit, filter means for selecting appropriate network members to receive said request for quotation based on filter conditions defined by the buyer in said request for quotation and/or by the vendor and/or by the central processing unit, means for broadcasting said request for quotation to the network members selected by said filter means and means for responding to the generator of said request for quotation with either a response to said request for quotation or with a list of said selected network members. Filter conditions may define the class of vendors in terms of geographical location, quantity, language spoken, currency, special conditions of sale, and the like.