baber/WOPTO huggingface dataset:
Patent EP-1215497-B1 (EP)
Inventor: AGUZZI ADRIANO
IPC: A61K35/12
Filed: 1997-12-16
Granted: 2009-01-07
Abstract: B-cells have been identified as being the crucial carriers of infectivity in the spread of transmissible spongiform encephalopathy within an infected animal. In a second step, B-cells may infect further component of the immune system, e.g. T-cells. Accordingly, the present invention provides B-cell and T-cell specific ligands for the use in diagnostics and therapeutics for transmissible spongiform encephalopathy and povides methods for the manufacture of non-infective blood products and tissue derived products. Thus, the present invention provides medicaments comprising B-cell and/or T-cell depletants, for the treatment of pathologies where the depletion of B-cells and/or T-cells, and more particularly of infective B-cells and/or T-cells is therapeutically effective. <IMAGE>
Patent EP-1346232-B1 (EP)
Inventor: WILSON JOHN
IPC: G01R31/58
Filed: 2001-12-11
Granted: 2004-09-29
Abstract: A test system employing a plurality of disconnect devices is provided. Each load, such as a lamp, has a local disconnect device which temporarily disconnects the load in order to protect it from high voltage during the test.
Patent EP-1267900-B1 (EP)
Inventor: SCHEFFLER ARMIN
IPC: C09K23/00
Filed: 2001-03-26
Granted: 2004-04-21
Abstract: The invention provides a continuous process for obtaining triterpenes from plants and/or their components. The process can include continuously washing at least one of plant and plant parts in counter-current at 20° C. to 70° C. with a solvent in which the triterpenes are not soluble or only slightly soluble and continuously extracting triterpenes from the washed plant part or parts with a solvent under an increased pressure and an elevated temperature relative to the washing pressure and temperature in counter-current to form a triterpene containing solution where the plant parts are conveyed in counter-current to the solvent flow, on the basis of their different density in a pressure-tight and heatable tube and are discharged at an end of the tube opposite to the solvent discharge. The process can also include the steps of continuously cooling and depressurizing the triterpene containing solution, where triterpene crystallizes out of the solvent, filtering the triterpene crystals from the solvent at room temperature and washing the triterpene crystals in fresh solvent.
Patent EP-1274726-B1 (EP)
Inventor: WIGHT THOMAS N
IPC: C12N5/08
Filed: 2001-04-12
Granted: 2009-12-23
Abstract: A method of increasing elastic fibers in human tissue comprises contacting the tissue ex vivo with an effective amount of an agent, wherein the agent increases the amount or activity of versican v3 in said tissue.
Patent EP-1274978-B1 (EP)
Inventor: SAEGLITZ MARIO
IPC: G01M17/08
Filed: 2001-04-19
Granted: 2004-06-23
Abstract: The invention relates to a method for monitoring the handling characteristics of a rail vehicle, whereby the acceleration behaviour of at least one vehicle component is monitored. To achieve this, a frequency distribution of the acceleration values of at least one vehicle component is detected over a predeterminable time period (t) and the frequency (H) of at least one acceleration value (a) is compared with a predeterminable frequency value and an event to be taken into consideration is identified, based on the relation between the frequency (H) of the acceleration value(s) (a) and the predetermined frequency value (H54). The invention also relates to a device for monitoring the handling characteristics of a rail vehicle. Said device comprises means for detecting the acceleration behaviour of at least one vehicle component of the rail vehicle, said means being used to detect a frequency distribution of acceleration values (a) over a predeterminable time period (t) and to compare the frequency (H) of at least one acceleration value (a) with a predeterminable frequency value (H54). If the predeterminable frequency value (H54) is attained, or if a predeterminable approximation to and/or deviation from said frequency value (H54) is/are attained, an event to be taken into consideration can be identified.
Patent EP-1280541-B1 (EP)
Inventor: RENAUD MICHEL
IPC: A61K35/742
Filed: 2001-05-11
Granted: 2006-04-12
Abstract: A method of modulating the microbial balance of the digestive ecosystem in a mammal comprising administering to a mammal in need thereof a composition comprising at least one nonpathogenic, hydrogenotrophic, acetogenic bacterial strain, along with a pharmaceutical and related methods, are described.
Patent EP-1282801-B1 (EP)
Inventor: VAN DONGEN FRANCISCUS GERARDUS
IPC: F22B1/18
Filed: 2001-05-18
Granted: 2007-02-28
Abstract: A process for heating steam, in which steam is obtained by indirect heat exchange between liquid water and a hot gas; (b) the steam obtained in step (a) is heated by indirect heat exchange with the partly cooled hot gas obtained in step (a); and (c) additional water is added to the steam obtained in step (a) prior to or during heating the steam in step (b).
Patent EP-1289557-B1 (EP)
Inventor: DAVIS STEPHEN THOMAS
IPC: A61K31/352
Filed: 2001-06-04
Granted: 2006-07-12
Abstract: The invention relates to a method for treating cancer including administering to a mammal therapeutically effective amounts of an anti-neoplastic agent and a PDE4 inhibitor, treatment combinations containing the same as well as a method for attenuating unwanted cancer treatment side effects including myelosuppression and mucositis.
Patent EP-1296843-B1 (EP)
Inventor: MCNULTY FRANK G
IPC: C21D9/50
Filed: 2001-06-11
Granted: 2008-11-26
Abstract: A vehicle structural beam, such as a door intrusion beam, which possesses an elongate tubular beam part which at opposite ends is provided with mounting flanges for securement to a vehicle frame. The elongate tubular beam part and the flanges provided at opposite ends are defined by an integral, one-piece, monolithic steel structure which has been initially roll-formed from an elongate flat metal sheet to define the closed tubular structure of the tubular beam part, and which has been subjected to heating and quenching so that the elongate tubular beam part is of relatively high strength steel throughout its entire length, whereas the integrally and monolithically joined end flanges remain as lower strength steel which has been significantly unaffected by the heat treatment and quenching so as to permit appropriate shaping thereof and ease of welding to the vehicle frame.
Patent EP-1408888-B1 (EP)
Inventor: KUSLICH STEPHEN D
IPC: A61F2/00
Filed: 2001-07-20
Granted: 2010-03-24
Abstract: Expandable fabric bags (22) and methods of use for reduction, fixation, support and treatment of bone abnormalities such as tibial plateau fractures, femoral head necrosis, compression fractures of the spine and other bone abnormalities.
Patent EP-1317309-B1 (EP)
Inventor: SACKS MEIR S
IPC: A61K9/107
Filed: 2001-08-29
Granted: 2005-07-20
Abstract: Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to the genitals of the patient. The methods allow for localized NO delivery through topical application of the present compounds, while minimizing, if not preventing, damage associated with peroxynitrite formation. Compositions comprising L-arginine, or a derivative thereof and an antioxidant in a pharmaceutical carrier suitable for application to the genitals is also disclosed.
Patent EP-1329125-B1 (EP)
Inventor: SHAHAF MARK
IPC: H04W64/00
Filed: 2001-10-15
Granted: 2007-01-03
Abstract: A mobile uses TDOA measurements of standard signals of a predefined type, such as control bursts, from neighbouring base stations for location. The system protocols may be based on TETRA and the standard data from the Broadcast network channel (BNCH.) The neighbouring base stations may be determined from the handoff list provided by the serving station. A sample of BCNH signal may be stored and correlated in order to detect the incoming signal. The system may use a digital time matched filter and may request that neighbouring stations repeatedly transmit a measurable signal on all available channel time slots.
Patent EP-1231199-B1 (EP)
Inventor: PROTZMANN GUIDO DR
IPC: C07C49/203
Filed: 2002-01-11
Granted: 2005-07-20
Abstract: Production of  alpha , beta -unsaturated ketones by reaction of aldehydes with ketones in the liquid phase in a tubular reactor is such that: (i) the catalyst is in the continuous phase and at least one starting material is in a disperse phase; and (ii) the loading factor of the tubular reactor is ≥ 0.8. Production of  alpha , beta -unsaturated ketones of formula (I) by reaction of aldehydes of formula (II) with ketones of formula (III) in the liquid phase in a tubular reactor is such that (i) the catalyst is in the continuous phase and at least one starting material is in a disperse phase; and (ii) the loading factor of the tubular reactor is ≥ 0.8. R<1> and R<2> = optionally unsaturated aliphatic or aliphatic-cycloaliphatic 1-20 (especially 1-16)C hydrocarbyl or optionally unsaturated cycloaliphatic 5-12C hydrocarbyl (which can contain alkyl substituents or an endoalkylene group), araliphatic 7-15C hydrocarbyl such as benzyl or aromatic hydrocarbyl such as phenyl; and R<3> = H or 1-10C aliphatic hydrocarbyl.; further, R<1> and R<3>, together with both adjacent C atoms can be members of an alicyclic ring and also one or more methylene groups not  alpha  to a carbonyl group can be substituted in R<1> R<3> by an O or S atom
Patent EP-1340507-B1 (EP)
Inventor: GOPPELT ANDREAS
IPC: A61K48/00
Filed: 2002-02-28
Granted: 2004-09-22
Abstract: Use of fibroblast growth factor binding protein (FGF-BP), nucleic acids encoding it, or their functional variants, antibodies against (FGF-BP) or their functional fragments, and/or cells that express (FGF-BP) or its variants, to prepare a composition for treatment, prevention and/or diagnosis of diabetes-associated wound-healing disorders, is new.  Use of: (i) fibroblast growth factor binding protein (I: FGF-BP), with human sequence S1 of 234 amino acids or murine sequence S3 of 251 amino acids or their functional variants;  (ii) nucleic acids (II) of 705 bp (S2) or 756 bp (S4), encoding (S1) and (S3), or their functional variants;  (iii) antibodies against (I) or their functional fragments; and/or  (iv) cells that express (I) or its variants, to prepare a composition for treatment, prevention and/or diagnosis of diabetes-associated wound-healing disorders.  Independent claims are also included for the following: (1) use of (I), (II), Ab and (I)-expressing cells for identifying substances (A) that increase the function and/or expression of (I) and/or (II), suitable for treating or preventing skin disorders characterized by reduced levels of (I); and  (2) use of the same materials as in (1) for preparing a reagent for diagnosis of wound-healing disorders characterized by reduced levels of (I).
Patent EP-1340870-B1 (EP)
Inventor: SPIESSL GEORG
IPC: F03G7/06
Filed: 2002-02-27
Granted: 2009-11-18
Abstract: The device has at least one memory metal actuator for producing the desired forces for using the door lock. The memory metal actuator produces the forces for locking the door lock when it is in the locked state and/or for releasing the door lock when it is in the locked state.  Independent claims are also included for the following: (1) a method of operating a unit for door lock of a domestic appliance;  (2) a door lock for a domestic device; and (3) a control unit for the door lock.
Patent EP-1256646-B1 (EP)
Inventor: THOMANN ANDREAS
IPC: D04B15/88
Filed: 2002-05-07
Granted: 2011-03-09
Abstract: A circular knitting machine for producing circular knitwear (15) is described, which is slit at one side, spread out with the aid of V-rolls (17) and then taken down and wound up in the spread out state. In accordance with the invention a guide element (44) if fitted at one end (33) of a fabric spreader (25) and extends up to a junction point (43) of the V-rolls (17). The knitwear (15) is guided by means of the guide element (44) in a controlled manner before running on to the V-rolls (17), such that backing-up and warping during its further transport are avoided.
Patent EP-1233367-B1 (EP)
Inventor: KITAGAWA TOSHIYA
IPC: G06K7/10
Filed: 2002-02-07
Granted: 2005-04-27
Abstract: There is provided an antenna apparatus in which a non-detection region is made minimum within the regulatory limit of radio wave radiation, and satisfactory communication is enabled over a wide range. Four substantially square antennas (11,12,13,14) are adjacently arranged on the same plane to constitute an antenna assembly (10), which is arranged to be opposite to a similar antenna assembly (20). Reverse phase currents flow to the first antenna and the third antenna, and similarly, reverse phase currents flow to the second antenna and the fourth antenna. The second and the fourth antennas are subjected to phase inversion for every data communication between a pattern (1) in which same phase currents flow to the second antenna and the third antenna and a pattern (2) in which same phase currents flow to the first antenna and the second antenna. A predetermined phase difference is provided between the first and the second antenna assemblies (10,20). <IMAGE>
Patent EP-1297864-B1 (EP)
Inventor: RYAN ALLEN L
IPC: A63B22/08
Filed: 2002-09-16
Granted: 2008-12-10
Abstract: A stationary exercise bicycle (10) is provided having a frame (12), a resistance member, a drive assembly (16), a right pedal (18), a left pedal (20), a seat (42) and an adjustable seat mechanism (24) utilizing a rack (100). Assembly and disassembly of a three piece crank arm assembly (62, 84, 86) is accomplished without requiring the assembling and disassembling of the entire drive assembly (16). The stationary exercise bicycle (10) also provides a variety of users with an optimum seat position and with a convenient latch mechanism (116) to adjust the position of the seat (42). <IMAGE>
Patent EP-1376639-B1 (EP)
Inventor: DIEBOLD FRANCIS
IPC: H01H71/24
Filed: 2002-06-17
Granted: 2004-09-08
Abstract: The electromagnetic switch has a hub surrounded by a half spiral driving coil. A fixed contact is placed near the magnetic gap. A plate unlocks the grip mechanism. The plate is moved and guided in translation along a magnetic yolk side, following a locking and unlocking path for an excess level input.
Patent EP-1361478-B1 (EP)
Inventor: KOKUBO HARUO
IPC: G03F1/00
Filed: 2002-02-15
Granted: 2009-12-30
Abstract: A substrate single-trench type phase shift mask, comprising a light shielding layer pattern having a shifter part and a non-shifter part positioned adjacent to each other and a light shielding film for continuously covering the shifter part ranging from the end part of the shifter part to the end part of the non-shifter part including the side surface parts of a trenched part (recessed part) for forming the shifter part, characterized in that the side surface parts are inclined divergently toward the surface of a substrate.
Patent EP-1373528-B1 (EP)
Inventor: DALY JOHN
IPC: C12N15/67
Filed: 2002-03-08
Granted: 2008-08-13
Abstract: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.
Patent EP-1370160-B1 (EP)
Inventor: LENOBLE HENRI-PIERRE
IPC: A23L23/10
Filed: 2002-02-08
Granted: 2011-03-30
Abstract: Stock cube for culinary preparation of liquid foods or food components in the form of a formed multi-ingredient stock cube, comprising at least two partial volumes which may be visually discriminated and/or discriminated by touch which correspond to food components with differing compositions, in particular those corresponding to meat and vegetable stocks.
Patent EP-1415374-B1 (EP)
Inventor: KATHMAN ALAN D
IPC: H01S5/02315
Filed: 2002-03-05
Granted: 2006-09-27
Abstract: A structure having an optical element thereon has a portion of the structure extending beyond a region having the optical element in at least one direction. The structure may include an active optical element, with the different dimensions of the substrates forming the structure allowing access for the electrical interconnections for the active optical elements. Different dicing techniques may be used to realize the uneven structures.
Patent EP-1393054-B1 (EP)
Inventor: INOUE TOMOHIRO
IPC: G01N27/407
Filed: 2002-05-23
Granted: 2011-08-24
Abstract: A MEA 6 having a proton conductive membrane is sandwiched by metal plates 14, 15 and they are further sandwiched by heat pressable films 20, 21 . An opening 24 and an opening 18 are formed in the heat pressable film 20 and the metal plate 14 , respectively so that an electrode 10 is used as the sensing electrode and exposed to atmosphere to be measured. Openings 25, 19 are formed in the heat pressable film 21 and metal plate 15 , respectively so that an electrode 11 is used as the counter electrode, and water vapor is supplied to the electrode from a water pack.
Patent EP-1389130-B1 (EP)
Inventor: BOSCHERT URSULA
IPC: A61K38/19
Filed: 2002-05-08
Granted: 2012-05-02
Abstract: The invention relates to the use of osteopontin, or of an agonist of osteopontin activity, for treatment or prevention of a neurologic diseases.
Patent EP-1399250-B1 (EP)
Inventor: MISTRY KISHOR KUMAR
IPC: C11D17/08
Filed: 2002-06-14
Granted: 2007-06-27
Abstract: A particulate composition comprising particles which consist of a shell wall surrounding a hydrophilic core, wherein the shell wall is formed from a polymeric coacervate and wherein the particles comprise a polymeric amphipathic stabiliser. Also claimed is a process of producing a particulate composition comprising particles which consist of a shell wall surrounding a hydrophilic core, comprising the steps of a) forming an aqueous liquid that contains a wall building material that is capable of forming the shell wall by coacervation, b) dispersing the aqueous liquid into a water immiscible liquid, which comprises a stabilising substance to form a dispersion that comprises aqueous droplets dispersed in a continuous phase of water immiscible liquid, c) subjecting the dispersion to coacervation conditions, such that the wall building material coacervates at the surface of the aqueous doplets, characterised in that the stabilising substance comprises a polymeric amphipathic stabiliser. Preferably the particulate composition obtainable by the process contains an active ingredient and is used in a detergent composition. The active ingredient preferably comprises any of detergency building ingredients, a buffering system and/or a sequesterant and/or detergent builder. Citric acid is a particularly preferred active ingredient.
Patent EP-1404194-B1 (EP)
Inventor: HUIBAN CHRISTIAN M
IPC: B60N2/90
Filed: 2002-06-20
Granted: 2005-03-09
Abstract: A seating device and a method include sensors of the limbs of the human body with a database with the users ergonomic data of the human body including the user's injury strain complains. A warning signal representing detected strain or damage in the limbs can be given. The ergonomic data includes the age, weight and characteristics of body limbs: neck, arms, hands, feet, legs; other abnormal shapes of body limbs; limbs, where a static situation should be avoided and preferred exercise is suggested when a warning signal is given. The warning signal can be given by lamps, light emitting diodes, a vibrator, a speaker, a buzzer, by a display or via an interface. The seating device can be remote-controlled by interfaces such as Bluetooth, IrDa, USB, or controlled by a computer integrated in the seating device. The sensors include pressure, temperature, proximity or camera.
Patent EP-1434852-B1 (EP)
Inventor: QUAIL PETER H
IPC: C12N1/19
Filed: 2002-08-23
Granted: 2007-04-25
Abstract: An artificial promoter system that can be fused upstream of any desired gene enabling reversible induction or repression of the expression of the gene at will in any suitable host cell or organisms by light is described. The design of the system is such that a molecule of the plant photoreceptor phytochrome is targeted to the specific DNA binding site in the promoter by a protein domain that is fused to the phytochrome and that specifically recognizes this binding site. This bound phytochrome, upon activation by light, recruits a second fusion protein consisting of a protein that binds to phytochrome only upon light activation and a transcriptional activation domain that activates expression of the gene downstream of the promoter.
Patent EP-1535916-B1 (EP)
Inventor: NIU ZHAN-QI
IPC: A61K47/48
Filed: 2002-08-21
Granted: 2010-12-01
Abstract: The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl- beta -cyclodextrin, in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
Patent EP-1444171-B1 (EP)
Inventor: DAWES STEVEN B
IPC: C03B37/014
Filed: 2002-09-24
Granted: 2012-05-09
Abstract: La présente invention se rapporte à un procédé de fabrication d'une préforme de guide d'ondes optique consistant à délivrer une première atmosphère gazeuse de traitement à une préforme à base de suie contenue dans une cuve. La première atmosphère est maintenue dans la cuve pendant un premier temps de réaction suffisamment long pour permettre un dopage ou un séchage au moins partiel de la préforme à base de suie. La cuve est ensuite au moins partiellement remplie avec une seconde atmosphère de dopage ou de séchage. Cette seconde atmosphère de dopage ou de séchage est maintenue dans la cuve pendant un second temps de réaction suffisamment long pour permettre un dopage ou un séchage ultérieur de la préforme à base de suie.
Patent EP-1461316-B1 (EP)
Inventor: REMERS WILLIAM
IPC: C07D487/04
Filed: 2002-09-17
Granted: 2010-02-24
Abstract: The present invention provides a process for producing an aziridine-1-carboxamide of the formula:from an aziridine of the formula:and an isocyanate of the formula R5-N=C=O, where R1, R2, R3, R4 and R5 are those defined herein. In addition, the present invention also provides a process for producing a 4-imino-1,3-diazabicyclo[3.1.0]-hexan-2-one of the formula:from the aziridine-1-carboxamide of Formula I.