baber/WOPTO huggingface dataset:
Patent AU-2018202185-A1 (AU)
Title: Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
Inventor: XU LINA
IPC: C07D231/12
Filed: 2018-03-27
Abstract: PRO-DRUGS OF NSAIAS WITH VERY HIGH SKIN AND MEMBRANES PENETRATION RATES AND THEIR NEW MEDICINAL USES Abstract The novel positively charged pro-drugs of NSAIAs in the general formulas (1, 2a, 2b, 2c, or 2d) "Structure 1, 2a, 2b, 2c, or 2d" were designed and synthesized. The compounds of the general formulas (1, 2a, 2b, 2c, or 2d) "Structure 1, 2a, 2b, 2c, or 2d" indicated above can be prepared from metal salts, organic base salts, or immobilized base salts of NSAIAs with suitable halide compounds. The positively charged amino groups in the pro-drugs in this invention largely increase the solubility of the drugs in water and will bond to the negative charge on the phosphate head group of membrane. Thus, the local concentration of the outside of the membrane or skin will be very high and will facilitate the passage of these pro-drugs from a region of high concentration to a region of low concentration. This bonding will disturb the membrane a little bit and may make some room for the lipophilic portion of the pro-drug. When the molecules of membrane move, the membrane may "crack" a little bit due to the bonding of the pro-drug. This will let the pro-drug insert into the membrane. At pH 7.4, only about 99% of the amino group is protonated. When the amino group is not protonated, the bonding between the amino group of the pro-drug and the phosphate head group of the membrane will disassociate, and the pro-drug will enter the membrane completely. When the amino group of the pro-drug flips to the other side of the membrane and thus becomes protonated, then the pro drug is pulled into the cytosol, a semi- liquid concentrated aqueous solution or suspension. These pro-drugs can be used for treating and preventing diabetes (type I or/and type II), abnormal blood glucose and lipid levels, stroke, heart attack, and other heart and vascular diseases, Alzheimer's diseases, Parkinson's diseases and other neurodegenerative diseases, psoriasis, discoid lupus erythematosus, systemic lupus erythematosus (SLE), autoimmune hepatitis, multiple sclerosis (MS), and other autoimmune diseases, amyotrophic lateral sclerosis (ALS), oculopharyngeal muscular dystrophy (OPMD), and other muscle disorders, inflamed hemorrhoids, cryptitis, other inflammatory conditions of the anorectum, and pruritus ani, prostatitis, prostatocystitis, varicose veins, autoimmune liver inflammation, autoimmune kidney inflammation, vein inflammation and other inflammations, skin cancers, breast cancer, colon rectum cancer, oral cancer, and other cancers, scars, abnormal vascular skin lesions, birthmarks, moles (nevi), skin tags, aging spots (liver spots), and other skin disorders. These pro-drugs can be administered transdermally without the help of skin penetration enhancers.
Patent AU-2018204044-A1 (AU)
Title: Antibody formulations and uses thereof
Inventor: BENEDICT Suzanne
IPC: A61K47/10
Filed: 2018-06-07
Abstract: The present application relates to formulations of anti-CD105 antibodies, antigen-binding fragments thereof, and uses thereof Another aspect relates to pre-filled syringes of the formulations of anti-CD105 antibodies or antigen-binding fragments thereof. Another aspect relates to the use of the formulations to reduce one or more signs or symptoms of an angiogenesis related disorder such as cancers and ophthalmologic diseases.
Patent AU-2018205122-A1 (AU)
Title: Isolated Polynucleotides and Polypeptides, and Methods of Using Same for Increasing Yield of Plants
Inventor: ADATO AVITAL
IPC: C12N15/82
Filed: 2018-07-11
Abstract: Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80 % identical to a nucleic acid sequence selected form the group consisting of SEQ ID NOs: 1-219, 367-5628, 9688-9700, and 9709-9752; and isolated polypeptides which comprise an amino acid sequence at least 80 % homologous to an amino acid sequence selected from the group consisting of SEQ ID NOs: 220-366, 5629-9400, 9701-9708, and 9753-9796. Also provided are transgenic cells and plants expressing same and methods of using same for increasing yield, growth rate, biomass, vigor, oil content, seed yield, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress of a plant.
Patent AU-2018209012-A1 (AU)
Title: BCMA-targeting antibody and use thereof
Inventor: WANG PENG
IPC: G01N33/68
Filed: 2018-01-23
Abstract: Provided in the present invention are a specific antibody of BCMA and a BCMA-targeting immune effector cell, and also provided are a chimeric antigen receptor-modified T cell prepared using the antibody and the use thereof.
Patent AU-2018217021-A1 (AU)
Title: Navigation guidewire with interlocked coils
Inventor: SEMA GHISLAIN G
IPC: A61M29/00
Filed: 2018-01-31
Abstract: An apparatus includes a proximal coil, a distal coil, a navigation sensor, and a wire. The proximal coil is formed by a wire wrapped in a helical configuration. The distal coil is formed by a wire wrapped in a helical configuration. At least one wrap at a proximal portion of the distal coil is interlocked with at least one wrap at a distal portion of the proximal coil, such that interlocking portions of the proximal and distal coils form a double helix configuration. The navigation sensor is located within the distal coil. The navigation sensor is configured to generate signals in response to movement within an electromagnetic field. The wire extends through the proximal coil. The wire is in electrical communication with the navigation sensor such that the wire is configured to communicate signals from the navigation sensor.
Patent AU-2018221251-A1 (AU)
Title: Selective laser induced optical breakdown in biological medium
Inventor: CAPELLI CRISTOPHER C
IPC: A61B5/05
Filed: 2018-02-19
Abstract: Apparatuses and methods for selectively providing laser induced optical breakdown (LIOB) of absorptive targets in biological media. For example, LIOB may be used as part of tissue therapy, such as cosmetic therapy associated with tattoo removal. In some implementation, a system for selectively providing LIOB includes a field generator configured to generate a field and to apply the field through a portion of a biological medium. The system also includes a light source configured to deliver laser light to the portion of the biological medium during application of the field. Application of the field to the biological medium induces movement of free electrons within the portion of the biological medium which may reduce or slow the formation of vacuoles in the biological medium responsive to the laser light.
Patent AU-2018223149-A1 (AU)
Title: Therapeutic dendrimers
Inventor: MCCOULL WILLIAM
IPC: A61P35/00
Filed: 2018-02-22
Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.
Patent AU-2018232909-A1 (AU)
Title: Therapy delivery devices and methods for non-damaging neural tissue conduction block
Inventor: BHADRA NILOY
IPC: A61N1/06
Filed: 2018-09-18
Abstract: THERAPY DELIVERY DEVICES AND METHODS FOR NON-DAMAGING NEURAL TISSUE CONDUCTION BLOCK Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device (10) into electrical communication with the neural tissue. The therapy delivery device (10) includes an electrode contact (12) having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device (10). The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
Patent AU-2018247348-A1 (AU)
Title: Amide compounds for the treatment of HIV
Inventor: BRIZGYS GEDIMINAS
IPC: C07D471/04
Filed: 2018-10-15
Abstract: C:\Interwoven\NRPortbl\DCC\RBR\17851690 l.docx-l/ 102018 Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
Patent AU-2018249356-A1 (AU)
Title: Washable floor mat with reinforcement layer
Inventor: VOGT KIRKLAND W
IPC: D06N7/00
Filed: 2018-03-05
Abstract: This invention relates to a washable floor mat comprising a reinforcement layer. The floor mat includes a textile component and a base component. The textile component contains a reinforcement layer which dramatically reduces and/or eliminates edge deformation that often occurs as a result of the washing process. The textile component and the base component may be joined together to form a single piece floor mat. Alternatively, the textile component and the base component may be releasably attachable to one another by at least one surface attraction means to form a multi-component floor mat. The floor mat is designed to be soiled, washed, and re-used, thereby providing ideal end-use applications in areas such as building entryways.
Patent AU-2018250380-A1 (AU)
Title: Tool joint finding apparatus and method
Inventor: LY LIZABETH J
IPC: E21B15/00
Filed: 2018-10-16
Abstract: An apparatus for identifying a tool joint connection is disclosed. The apparatus comprises a scanning system configured to scan an exterior of a drill string and at least one distance measuring sensor mounted to a movable platform, and a computer operatively connected to the scanning system and the distance measuring sensor. The computer is configured to receive data from a scanning of the exterior of the drill string and compare the data to a reference which enables a presence of the tool joint connection to be determined. A method for identifying a tool joint connection is also disclosed. FIG. 6 for publication - LINE X H = LINE X (tan(a) - tan(#))
Patent AU-2018263980-A1 (AU)
Title: Low-complexity intra prediction for video coding
Inventor: BOSSEN FRANK JAN
IPC: H04N7/00
Filed: 2018-11-12
Abstract: The present invention provides a unique intra prediction process which improves the efficiency of video coding. H.264/AVC uses reference pixels in a horizontal boundary located immediately above a target block to be predicted and reference pixels in a vertical boundary located immediately let of the target block. In the present invention, at least some of one of an array of horizontal boundary pixels and an array of vertical boundary pixels are retrieved. Then, the retrieved pixels are added to the other boundary pixels to extend the array thereof. Intra prediction is performed, based solely on the extended array of boundary pixels. DAA20)f1 /1A~7A-)2z
Patent AU-2018268566-A1 (AU)
Title: Smart cabinet system and control method therefor
Inventor: WEI TAO
IPC: G07F17/12
Filed: 2018-05-18
Abstract: A smart cabinet system and a control method therefor. The system comprises a cabinet (8), an article information recording module (1), an article position memory module (2), an article position display module (3), a central control module (4). A plurality of storage areas (9) are provided in the cabinet. The central control module (4) is connected to the article information recording module (1), the article position memory module (2), and the article position display module (3). The method comprises: the article information recording module (1) inputting article information into the central control module (4), after an article is placed into the cabinet (8), the article position memory module (2) memorizing the position thereof and inputting same into the central control module (4) to establish an association relationship with the article information; and during picking, after the central control module (4) retrieves the article information, the article position display module (3) displaying the article position.
Patent AU-2018271371-A1 (AU)
Title: A system, valve, and method for liquid resin infusion
Inventor: ROBERTS RICHARD W
IPC: B29C70/68
Filed: 2018-11-30
Abstract: A SYSTEM, VALVE, AND METHOD FOR LIQUID RESIN INFUSION Described herein is a system (100) for infusing liquid resin into a sheet (104) of fibrous material. The system comprises a tool (102) and a permeable media layer (108) configured to have the sheet therebetween. The system further comprises a non-permeable bladder (110) configured to be sealed to the tool about the sheet of fibrous material and the permeable media layer such that the sheet of fibrous material and the permeable media layer are sealed between the non-permeable bladder and the tool. The system additionally comprises an inlet (126) selectively fluidically coupleable with the permeable media layer to deliver liquid resin to the permeable media layer. The system also comprises an outlet (127) selectively fluidically coupleable with the permeable media layer to create a pressure differential across the non permeable bladder. The system further comprises a permeability control valve (115, 117) selectively operable to adjust the permeability of the permeable media layer.
Patent AU-2018294423-A1 (AU)
Title: Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures
Inventor: DASI LAKSHMI PRASAD
IPC: A61F2/24
Filed: 2018-06-29
Abstract: A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame.
Patent AU-2018306539-A1 (AU)
Title: Peptide mapping method for sequence identification of insulin and insulin analogues
Inventor: KODALI PHANICHAND
IPC: G01N33/68
Filed: 2018-07-20
Abstract: The invention relates to peptide mass fingerprinting technique for the proteins such as Human insulin and insulin analogs. The insulin analogues can vary at least by one amino acid, which is elusive to distinguish by currently available analytical methods. The invention further allows sequence confirmation of the peptide wherein the run time of the method is forty minutes. This method could be applied for molecules up to 50kDa.
Patent AU-2018308773-A1 (AU)
Title: IL-15 protein complex pharmaceutical composition and uses thereof
Inventor: WU TINGTING
IPC: A61P37/02
Filed: 2018-07-24
Abstract: A pharmaceutical composition, which comprises an IL-15 protein complex and a citrate buffer solution. In addition, the pharmaceutical composition may also comprise a sugar and a non-ionic surfactant. The pharmaceutical composition demonstrates a high degree of stability even after being stored at 2-8 °C for several months.
Patent AU-2018317930-A1 (AU)
Title: Recovery of precious and chalcophile metals
Inventor: EKSTEEN JACOBUS JOHANNES
IPC: C22B11/00
Filed: 2018-08-13
Abstract: A process for recovery of one or more elements, selected from precious metals and chalcophile metals, as herein defined, from materials containing precious and/or chalcophile metal/s, said process including: (i) contacting the material with an alkaline solution containing a lixiviant comprising an amino acid, or derivative thereof, and an alkali stable transition metal complex in order to form a leachate containing the precious metal and/or chalcophile metal; and (ii) recovering the precious metal and/or chalcophile metal from the leachate.
Patent AU-2018330323-A1 (AU)
Title: Extracellular vesicles from Prevotella
Inventor: GOODMAN BRIAN
IPC: C07K14/195
Filed: 2018-09-10
Abstract: Provided herein are methods and compositions related to
Patent AU-2018338424-A1 (AU)
Title: Method and device for efficiently distributing a bit-budget in a CELP codec
Inventor: EKSLER VACLAV
IPC: G10L19/038
Filed: 2018-09-20
Abstract: A method and device allocates a bit-budget to a plurality of first parts of a CELP core module of (a) an encoder for encoding a sound signal or (b) a decoder for decoding the sound signal. In the method and device, bit-budget allocation tables assign, for each of a plurality of intermediate bit rates, respective bit-budgets to the first CELP core module parts. A CELP core module bit rate is determined and one of the intermediate bit rates is selected based on the determined CELP core module bit rate. The respective bit-budgets assigned by the bit-budget allocation tables for the selected intermediate bit rate are allocated to the first CELP core module parts.
Patent WO-2019178640-A1 (WO)
Inventor: JOLIC KARLO IVAN
IPC: G01N21/95
Filed: 2019-03-20
Abstract: A system for detecting defects in printed imagery used for generating optically variable images, the system comprising: a print feed path for media substrate to be printed with the imagery; a print station for printing the imagery and a test pattern on the media substrate, the test pattern having image elements spaced apart by gaps; and an image sensor for capturing images of the test pattern; such that, brightness levels acquired from the test pattern by the image sensor are used to derive a contrast measurement for comparison to a reference contrast level.
Patent WO-2020000059-A1 (WO)
Inventor: JACKSON CHRISTOPHER JOHN
IPC: A61P17/00
Filed: 2019-06-28
Abstract: The invention relates to a method of minimising a symptom of dermatitis in an individual having a skin disease or condition comprising the administration of a TR47 related peptide, wherein the TR47 related peptide generally refers to a peptide having an N-terminal sequence NH2-NPND or NH2-NPNDKY, which is derived from the N-terminal sequence of the Met1-Arg46 deleted human PAR1 (protease activated receptor 1) sequence.
Patent AU-2019201024-A1 (AU)
Title: Gaming device with a changing arrangement of symbol display positions
Inventor: CHAN MATTHEW JAMES
IPC: G07F17/32
Filed: 2019-02-14
Abstract: A gaming device comprises a display, a processor, and a memory storing (a) a 
current symbol position state defining, for each of a plurality of columns of 
symbol positions, a number of symbol positions for which symbols are to be 
selected; (b) a pay table; and (c) instructions. When the instructions are executed 
by the processor cause the processor to control the display to display a plurality 
of columns of symbol positions corresponding to the current symbol position 
state, select symbols for the displayed symbol positions by selecting stopping 
positions of a plurality of reel strips, wherein at least one of the reel strips 
comprises at least one designated symbol, evaluate the selected symbols for 
winning combinations based on the pay table, and responsive to the selected 
symbols of a column including a designated symbol, modify the symbol position 
state for the respective column to include at least one additional symbol position 
for a next symbol selection.
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Patent AU-2019202954-A1 (AU)
Title: A gaming system and method of gaming
Inventor: FONG COLIN
IPC: A63F13/00
Filed: 2019-04-26
Abstract: The present invention provides a gaming system, comprising a game controller arranged to control play of a game, the game comprising a plurality of selectable game play 5 characteristics, the game controller being arranged to control play of the game such that one or more of the selectable game play characteristics are played in the game. In an embodiment, the game controller is arranged to control operation of a characteristic selection game, an outcome of 10 the characteristic selection game being which of the selectable game play characteristics will be played in the game. GAME CONTROLLER 300 SMBOL SYMBLSOE _-3 0 3 SELECTOR SMO TR OUTCOME DISPLAY 301 GENERATOR CONTROLLER igure 6
Patent AU-2019204199-A1 (AU)
Title: Multiplexing of high count electrode catheter(s)
Inventor: ZIV-ARI MORRIS
IPC: A61B8/12
Filed: 2019-06-14
Abstract: A method is disclosed comprising: performing a first scan of an organ using a set of electrodes in a catheter that are currently active; deactivating one or more of the electrodes in the set based on data that is collected as a result of the first scan; tuning the set by at least one of (i) deactivating one or more electrodes in the set that remain active after the deactivating, and (ii) activating one or more electrodes in the catheter that are inactive; performing a second scan of the organ using electrodes in the set that are currently active after the tuning is performed, and generating a map of the organ based on data collected as a result of the second scan; and outputting the map of the organ for presentation to a user. Gcc U-
Patent AU-2019204570-A1 (AU)
Title: Pulsed-beam atomic magnetometer system
Inventor: BULATOWICZ MICHAEL D
IPC: G01R33/26
Filed: 2019-06-27
Abstract: One example includes a magnetometer system that includes a sensor cell comprising alkali metal vapor and at least one measurement zone corresponding to a three-dimensional spatial region within the sensor cell. The system also includes a laser system configured to provide an optical pump beam through the sensor cell in a pulsed manner to facilitate precession of the alkali metal vapor in response to an external magnetic field and to provide an optical probe beam through the sensor cell in a pulsed manner based on a precession frequency of the alkali metal vapor. The system also includes a detection system configured to detect the precession of the alkali metal vapor in response to a detection beam corresponding to the optical probe beam exiting the sensor cell and to calculate an amplitude and direction of the external magnetic field based on the detected precession of the alkali metal vapor. 11479555_1 (GHMatters) P111490.AU 10-7 12 18 26 DETECTION SENSOR CELL SYSTEM LASER SYSTEM -2 -28 14 : UPLOPIPMP. ZN1 OPTICAL 10BSCLR PUMP LASER(S) 1 OPTDET DETECTOR(S) 16 PROBE OPTPRB ZONE 2 -22 TIMING BGRDT LASERS) 3O-ECONTROLLER 52 m5 56 52X oe-6
Patent AU-2019208197-A1 (AU)
Title: Fixation devices and prostheses for soft tissue connection to the same
Inventor: SERVIDIO DAMON J
IPC: A61F2/38
Filed: 2019-07-24
Abstract: An orthopedic assembly is disclosed including a tibial prosthesis that includes a body that defines an anterior side and a posterior side. The body further includes a recess in the anterior side of the joint prosthesis and a plurality of openings that extend through the body from the anterior side to the posterior side thereof. At least a first and second opening of the openings may be positioned at respective lateral and medial sides of a longitudinal axis of the tibial prosthesis. A modular insert may be positioned within the recess of the body such that at least a portion of the modular insert is positioned between the openings of the body. The modular insert is formed separately from the tibial prosthesis and has a porous outer surface to promote tissue ingrowth. FIG. 3 for publication 112a 112b 123a' 123b /124 121 ,/