baber/WOPTO huggingface dataset:
Patent CA-3143246-A1 (CA)
Inventor: GOWTHAM YOGENDER KUMAR
IPC: A61K9/00
Filed: 2020-06-10
Abstract: L'invention concerne des procédés de culture cellulaire pour produire un anticorps anti-a4ß7, par exemple, le védolizumab, ainsi que des compositions de ceux-ci
Patent CA-3149919-A1 (CA)
Title: Formulations de vaccin contre le chikungunya
Inventor: REINISCH CHRISTOPH
IPC: A61K9/19
Filed: 2020-08-10
Abstract: La présente invention concerne de nouvelles formulations liquides et lyophilisées de virus Chikungunya utiles en tant que vaccins et des procédés pour leur préparation.
Patent CA-3152341-A1 (CA)
Title: Systemes et procedes de fabrication de dispositifs microfluidiques fermes
Inventor: AZIZGOLSHANI HESHAM
IPC: B81C1/00
Filed: 2020-09-24
Abstract: Procédé de fabrication d'un dispositif microfluidique pouvant comprendre la fourniture d'un composant de base pour définir une première partie du dispositif microfluidique. Un composant de capuchon du dispositif microfluidique peut être fabriqué avec une lèvre d'étanchéité s'étendant à une première distance d'un premier côté du composant de capuchon et une partie de support s'étendant sur une seconde distance, inférieure à la première distance, à partir du premier côté du composant de capuchon. Le procédé peut comprendre le positionnement du composant de capuchon et du composant de base à l'intérieur d'un moule pour amener la lèvre d'étanchéité du composant de capuchon en contact avec le composant de base. Le composant de base, la partie de support du composant de capuchon et la lèvre d'étanchéité du composant de capuchon ensemble peuvent définir une cavité. Le procédé peut comprendre l'injection d'un matériau polymère dans le moule pour amener le matériau polymère à remplir la cavité.
Patent CA-3152556-A1 (CA)
Inventor: YU HYEON JAE
IPC: B29C45/78
Filed: 2020-11-03
Abstract: La présente invention concerne un système de moulage par injection basé sur l'intelligence artificielle dans lequel, selon un aspect, des conditions de moulage peuvent être modifiées pour produire des produits de bonne qualité lorsque des produits défectueux sont produits en raison de perturbations pendant le moulage de produits par injection. Le système comprend : une machine de moulage par injection (100), qui effectue un moulage par injection d'un produit par injection d'une matière à mouler dans un moule ; une unité d'acquisition de données d'état d'injection (710) pour l'acquisition, pendant le moulage du produit par injection, de données d'état d'injection du moment qui comprennent le profil de viscosité de la matière à mouler injectée dans le moule et/ou sa valeur de pression d'injection ; une unité de détermination (720), qui entre les données d'état d'injection du moment dans un modèle de maintien de qualité de moulage (735) entraîné avec des données d'état d'injection cibles prédéfinies, de façon à déterminer s'il faut maintenir la qualité du moulage ou non ; et une unité de réglage de conditions de moulage (730) pour la modification d'une condition de moulage prédéfinie de telle sorte que les données d'état d'injection du moment suivent les données d'état d'injection cibles, lorsque l'unité de détermination (720) détermine qu'il ne faut pas maintenir la qualité du moulage.
Patent CA-3152581-A1 (CA)
Inventor: LAVALLEE PIERRE
IPC: A23K40/00
Filed: 2020-04-16
Abstract: The present disclosure relates to processes for recovering valuable products from Fabaceae family plant fractions, in particular from Medicago sativa ssp. The processes disclosed herein include processes for obtaining macrofibers, microfibers, a saponin precursor, chloroplast liquid and dry compositions and a Rubisco precursor. There is also disclosed herein processes for extracting from Fabaceae family plants valuable compounds such as proteins, enzymes, peptides, amino acids, fatty acids, fatty alcohols, terpenes, phenols and pigments. The processes may comprise at least one of separating plant fibers while attenuating shear forces, maintaining the temperature at or below 45 C, maintaining the pH above 4 and adding antioxidant and/or antimicrobial agents. Compositions comprising these recovered Fabaceae family plant products and uses thereof are also disclosed.
Patent CA-3153785-A1 (CA)
Inventor: LU YUEFENG
IPC: C07K14/54
Filed: 2020-09-28
Abstract: La présente invention concerne de nouveaux promédicaments d'IL-12. La présente invention concerne en outre des procédés de production et d'utilisation des nouveaux promédicaments.
Patent CA-3155114-A1 (CA)
Title: Inhibiteurs de ssao et leur utilisation
Inventor: REN ZAIFANG
IPC: C07D319/12
Filed: 2020-10-28
Abstract: L'invention concerne un composé de formule (I') ou (I), un sel, un hydrate, un solvate, un promédicament, un stéréoisomère ou un tautomère pharmaceutiquement acceptables de celui-ci, qui module l'activité de SSAO, une composition pharmaceutique comprenant un composé de formule (I') ou (I), et un procédé de traitement ou de prévention d'une maladie dans laquelle le SSAO joue un rôle.
Patent CA-3155916-A1 (CA)
Title: A multilayer cover element for sealing capsules for making beverages
Inventor: GOGLIO FRANCO
IPC: B65D85/804
Filed: 2020-10-14
Abstract: A cover element (1) for sealing capsules (100) for use in making brewed beverages comprises a main layer (2) having an inner surface (2a) that faces a housing zone (106) of a capsule (100) for making brewed beverages and an outer surface (2b) opposite to the inner surface (2b), the main layer (2) being made of compostable material; a protective layer (3) overlying the outer surface (2b) of the main layer (2); a filtering layer (4) underlying the inner surface (2a) of the main layer (2); at least the main layer (2) has a plurality of lines of weakness (12) formed on at least one of the surfaces (2a, 2b).
Patent CA-3157315-A1 (CA)
Inventor: BHURRUTH-ALCOR YUSHMA
IPC: A61P35/00
Filed: 2020-11-06
Abstract: Disclosed are compounds, methods, compositions, uses, and kits that allow for treating cancer. In some embodiments, the compounds are used to treat diseases or disorders. The compounds may treat cancer by targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, lymphoma, liver cancer, endometrial cancer, leukemia, or multiple myeloma. Disclosed are compounds, methods, compositions, uses, and kits that may be used in regenerative medicine. The compounds utilized in the disclosure are of Formula (0) and (I).
Patent CA-3160396-A1 (CA)
Inventor: MARTENS HUBERT
IPC: A61L31/08
Filed: 2020-12-04
Abstract: The use of neurostimulation leads in the craniofacial region is associated with skin erosion and lead migration. The cylindrical shape and associated thickness of state-of-the-art leads results in the lead eroding through the skin or results in the lead being displaced so that the electrodes no longer cover the targeted nerves. An implantable stimulator 1001110 is provided having a substrate 300, 1400 comprising a conformable portion with an electrode array, and a pulse generator 500. A plurality of electrical interconnections 250, 1210 are positioned between the surfaces of the substrate The conformable portion has a thickness equal to or less than 0.5 millimeters. Optionally, one or more encapsulation layers 1300 may be provided. Optionally, one or adhesion layers 1500 may also be provided comprising a ceramic material. By providing a more easily patternable substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array, user comfort may be increased. The one or more adhesion layers improve the performance of the encapsulation.
Patent CA-3162918-A1 (CA)
Title: Split multiple coil electric induction heat treatment systems for simultaneous heating of multiple features of a bearing component
Inventor: RUDNEV VALERY I
IPC: H01F5/00
Filed: 2021-02-03
Abstract: A master inductor circuit is connected to an alternating current power source and a passive inductor circuit are assembled as a separable split inductor assembly to form at least one pair of a master heating inductor and a passive heating inductor where the master and passive inductor circuits are electromagnetically coupled without physical connection. A bearing component can be brought into the presence of the magnetic flux field created by the master and passive heating inductors to simultaneously induction heat one or more bearing features on the bearing component with subsequent quenching down austenitized bearing features on the bearing component.
Patent CA-3162961-A1 (CA)
Title: Materiau a base d'aluminium en poudre resistant a la chaleur
Inventor: MANN VIKTOR KHRIST'YANOVICH
IPC: B33Y70/00
Filed: 2020-11-23
Abstract: L'invention se rapporte au domaine de la métallurgie, notamment des alliages d'aluminium résistant à la chaleur que l'on utilise dans des techniques additives. Cet alliage comprend du nickel, du manganèse, du fer, du zirconium, du cérium, au moins un élément choisi dans le groupe comprenant cuivre, magnésium, zinc, et au moins un élément choisi dans le groupe comprenant silicium, calcium, sachant que Ni > Mn + Fe, une ou plusieurs des phases eutectiques Al3Ni, Al16Mn3Ni, Al9FeNi ayant une stabilité thermique, et des dispersoïdes de type Al3Zr, ce qui garantit une résistance à la traction de l'article d'au moins 370 MPa. Le résultat technique consiste en l'élaboration d'un matériau à base d'aluminium que l'on utilise sous forme de poudre ayant une bonne aptitude à la production lors de l'impression et des caractéristiques accrues de résistance à température ambiante après l'impression, sans réduire fortement la résistance après le recuit.
Patent CA-3163275-A1 (CA)
Title: Double encapsulated styro-aircrete building panels
Inventor: BRADLEY PHILIP
IPC: B28B23/02
Filed: 2022-05-30
Abstract: The present disclosure provides designs and methods for manufacturing precast fully-encapsulated bilayered fiberglass Styro-aircrete building blocks. The disclosure comprises forming a super-light air-entrained Styro-aircrete building panel for a wall, roof, or beam. The Styro-aircrete is made with a novel composition/formula using shredded Styrofoam and other traditional Styro-aircrete ingredients that are mixed. Wire meshes and fiberglass fibers are pre-embedded in the panel frame to keep the structure in place. The Styro-aircrete is poured into a fiberglass panel frame from an opening, set aside to dry for a few days, and then sealed with a fiberglass cover. This frame and cover are double-layered fiberglass and form an all six-side enclosed casing. The method and designs improve a Styro-aircrete building block with the following: (1) much lighter weight; (2) longed durability; (3) increased compressive strength for load-bearing support; (4) reduced cost and installation time.
Patent CA-3164428-A1 (CA)
Title: Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
Inventor: SAHIN UGUR
IPC: C07K14/705
Filed: 2021-02-02
Abstract: The present disclosure relates to methods and compositions for inducing an immune response in a subject comprising providing to the subject a peptide or protein vaccine and a binding agent, such as a bispecific antibody, binding to PD-L1 and CD137, such as human PD-L1 and human CD137, e.g., by coadministering to the subject a peptide or protein used for vaccination or a polynucleotide, in particular RNA, encoding a peptide or protein used for vaccination, and a binding agent binding to PD-L1 and CD137 or a polynucleotide, in particular RNA, encoding a binding agent binding to PD-L1 and CD137. The present disclosure further relates to medical preparations useful in the methods disclosed herein.
Patent CA-3166362-A1 (CA)
Inventor: ANDRESEN HEDDIES
IPC: A63B69/00
Filed: 2020-12-29
Abstract: L'invention concerne un dispositif d'apprentissage de l'appui tendu renversé (10, 100). L'invention vise à permettre à l'utilisateur (50) d'apprendre à réaliser un appui tendu renversé et à maintenir cet appui sans utiliser de dispositif par la suite, le dispositif d'apprentissage de l'appui tendu renversé (10) présentant un élément principal (11, 111) et un élément de support (13) présentant une surface de contact (14) pour un bras (52).
Patent CA-3168788-A1 (CA)
Title: Arylamide derivative having antitumor activity
Inventor: ISSHIKI YOSHIAKI
IPC: A61K31/166
Filed: 2021-01-21
Abstract: The present disclosure provides, for example, compounds represented by general formula (6) [in the formula, X1, X2, X3, and X4 are each independently -CR2= or -N=; R2 is, for example, a halogen atom; R1 is, for example, -S(=O)2-NH-R8; R8 is, for example, a C1-6 alkyl group; R3 is, for example, a hydrogen atom; R5 is, for example, a halogen atom; R6 is, for example, a hydrogen atom; and R4 is, for example, a cyclopropyl group] or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt. The compounds, salts, and solvates provided by the disclosure have high RAF/MEK complex stabilization activities and can be used for the treatment or prevention of cell proliferation diseases and particularly cancers.
Patent CA-3172326-A1 (CA)
Inventor: TANAKA FABIO O
IPC: E21B43/267
Filed: 2021-03-23
Abstract: La présente divulgation concerne un diffuseur inversé utilisable dans des têtes de puits et d'autres équipements de site de forage. Le diffuseur inversé comprend au moins une première section comportant une première surface interne verticale, une première surface intérieure inclinée par rapport à la première surface intérieure verticale, et un canal ou plusieurs canaux soutenant un ou plusieurs éléments de fixation libérables entre la ou les premières sections et une paroi d'une tête de puits ou d'un équipement de site de forage. Au moins une seconde section est ajustée par pression ou fixée à côté de la ou des premières sections. Sont également divulgués un procédé d'application du diffuseur inversé dans une tête de puits et dans d'autres équipements de site de forage, ainsi qu'un procédé de fabrication du diffuseur inversé.
Patent CA-3174748-A1 (CA)
Title: Utilisation de masitinib pour le traitement de la maladie a coronavirus 2019 (covid-19)
Inventor: MOUSSY ALAIN
IPC: A61P31/14
Filed: 2021-04-09
Abstract: La présente invention concerne le masitinib, ou un sel ou solvate pharmaceutiquement acceptable de celui-ci, destiné à être utilisé dans le traitement d'une infection à coronavirus, telle qu'une infection par le SRAS-CoV-2 provoquant la maladie à coronavirus 2019 (COVID-19), chez un sujet en ayant besoin.
Patent CA-3175353-A1 (CA)
Inventor: CHRISTMAS JAMIESON
IPC: G02B27/18
Filed: 2022-09-16
Abstract: A head-up display for a vehicle comprising a first pupil replicator and second pupil replicator. The first pupil replicator extends in a first direction. The first pupil replicator is arranged to receive a holographic light field from a spatial light modulator having a pixel array defining a limiting aperture of the head-up display. A holographic light field is a complex light field spatially modulated in accordance with a hologram displayed on the spatial light modulator. The second pupil replicator extends in the first direction and in a second direction perpendicular to the first direction. The second pupil replicator comprises a first major surface forming an output and a second major surface parallel to the first major surface. The first pupil replicator is arranged within a planar layer substantially parallel and adjacent to the second major surface of the second pupil replicator.
Patent CA-3175966-A1 (CA)
Title: Agencement, appareil de forage et procede associe pour la detection d'eau dans un ecoulement de matiere
Inventor: MERKEL HARALD FRANZ ARNO
IPC: G01N33/28
Filed: 2021-03-31
Abstract: L'invention concerne un agencement (1) pour détecter de l'eau dans un flux de matière (20) pendant le forage, l'agencement (1) comprenant une unité de commande (2), une unité d'acquisition de données (3) et un capteur (4), le capteur comprenant au moins deux sondes (5), lesdites au moins deux sondes (5) devant être agencées en contact avec le flux de matière et étant reliées à une source de tension programmable et à un récepteur de tension programmable. L'agencement est conçu pour : mesurer un rapport entre une forme d'onde de tension reçue et une forme d'onde de tension appliquée pour un ensemble de fréquences prédéterminées ; déterminer une impédance complexe entre lesdites au moins deux sondes (5) pour chacune des fréquences prédéterminées, sur la base du rapport mesuré ; déterminer un ensemble de valeurs moyennes temporelles de l'impédance complexe déterminée pour chacune des fréquences prédéterminées, à l'aide d'une fenêtre temporelle ; déterminer un ensemble d'écarts types, sur la base des valeurs moyennes temporelles déterminées ; et indiquer que l'eau est détectée lorsqu'au moins l'un desdits écarts types dépasse une condition de seuil.
Patent CA-3176134-A1 (CA)
Inventor: PARRAG IAN CHARLES
IPC: C07J75/00
Filed: 2021-04-29
Abstract: Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. Said compositions and methods comprise steroids and prostaglandins which demonstrate anti-inflammatory activity, intraocular pressure (IOP) lowering, and/or other desirable activities. Injection of said compositions in the eye provides therapeutic benefit to patients suffering from ocular disorders.
Patent CA-3176537-A1 (CA)
Inventor: BRAGHIROLI MARCO
IPC: B64D33/10
Filed: 2021-04-27
Abstract: An aircraft (1) with a motor bay (8) is described; a motor system (6) with a discharge duct (17); a heat exchanger (20) arranged outside said motor system (6); a first air intake (25); a first duct (26) along which the heat exchanger (20) is arranged; a first converging nozzle (15) having a downstream section (39) fluidically connected with the discharge duct (17) and with the first duct (26) so as to create a first flow rate of air adapted to cool the heat exchanger (20); and a second air intake (10) that is open in the motor bay (8) and distinct from the first air intake (25); a second converging nozzle (16) having a second downstream section (49) fluidically connected with the discharge duct (17) and with the motor bay (8), so as to create a second flow rate of cooling air of the motor bay (8) directed from the second air intake (10) towards the discharge duct (17) and by-passing the motor system (6).
Patent CA-3176629-A1 (CA)
Inventor: TAFUNI DOMENICO
IPC: B64C13/04
Filed: 2022-09-27
Abstract: A Stability and Control Augmentation System ("SCAS") module includes a SCAS  actuator (610). The SCAS actuator (610) has a substantially cylindrical hydraulic chamber having a first and second regions (620, 625). A piston (630) is arranged for linear motion in first and second directions along an axis of the hydraulic chamber. The SCAS module (600) also includes a valve system (635) for controlling a flow of a hydraulic fluid into the hydraulic chamber. The valve system (635) has: at least one supply line (672) arranged to provide a first fluid flow path to the first region (620) of the hydraulic chamber and/or a second fluid flow path to the second region (625) of the hydraulic chamber, and a moveable valve member (660) arranged to have a position between a first and second positions.
Patent CA-3177093-A1 (CA)
Title: Methods for targeted insertion of exogenous sequences in cellular genomes
Inventor: YANG MING
IPC: C12N15/90
Filed: 2021-05-06
Abstract: The present disclosure provides methods for targeted insertion of an exogenous sequence at a genomic locus in a cell, wherein said insertion is induced by a sequence- specific endonuclease that has cleavage activity at said locus, at least 5 hours before the introduction into said cell of a DNA template comprising said exogenous sequence.
Patent CA-3179992-A1 (CA)
Inventor: PERLADE ASTRID
IPC: C21D6/00
Filed: 2021-07-12
Abstract: The invention deals with a cold rolled, annealed and partitioned steel sheet, made of a steel having a composition comprising, by weight percent: C: 0.05 - 0.18 % Mn: 6.0  11.0 % Mo: 0.05 - 0.5 % B: 0.0005  0.005% S = 0.010 % P = 0.020 % N = 0.008 % and comprising optionally one or more of the following elements, in weight percentage: Al < 3% Si = 1.20 % Ti = 0.050 % Nb = 0.050 % Cr = 0.5 % V = 0.2 % the remainder of the composition being iron and unavoidable impurities resulting from the smelting, said steel sheet having a microstructure comprising, in surface fraction, - from 0% to 30% of ferrite, such ferrite, when present, having a grain size below 1.0 µm, - from 8% to 40% of retained austenite, the fraction of austenite islands with a size above 0.5 µm being below or equal to 5% - from 30 to 92% of partitioned martensite - less than 3% of fresh martensite, - a carbon [C]A and manganese [Mn]A content in austenite, expressed in weight percent, such that the ratio ([C]A  x [Mn]A) / (C%  x Mn%) is below 18.0, C% and Mn% being the nominal values in carbon and manganese in weight %.
Patent CA-3180042-A1 (CA)
Title: Rooftop tent
Inventor: PARK SOON GYU
IPC: E04H15/02
Filed: 2022-10-18
Abstract: The present disclosure relates to a rooftop tent. A rooftop tent according to an embodiment of the present disclosure includes a rooftop tent main body including a tent member configured to be folded on a roof of a vehicle and stand when being unfolded toward a lateral side of the vehicle, a rotary canopy rotatably connected to the tent member, and a controller connected to the tent member and the rotary canopy and configured to fold the rotary canopy upward so that portions of the rotary canopy overlap one another.
Patent CA-3184403-A1 (CA)
Title: Anti-claudin 18.2 antibody and antibody-drug conjugate thereof
Inventor: FANG JIANMIN
IPC: C07K16/28
Filed: 2022-05-07
Abstract: Provided are an antibody targeting Claudin 18.2, an antibody-drug conjugate, and use thereof in treatment of cancer. Also provided are a nucleotide encoding the Claudin 18.2 antibody, a polynucleotide combination, an expression vector, an expression vector combination, a pharmaceutical composition comprising the Claudin 18.2 antibody and the antibody-drug conjugate, and an application thereof in preparation of a medication for treatment or prevention of cancer.
Patent CA-3189597-A1 (CA)
Inventor: MELTZER ROBERT
IPC: C12Q1/6811
Filed: 2021-07-15
Abstract: The disclosure provides methods for creating long oligonucleotide reagents that include barcodes and other element for sequencing library preparation, where the oligonucleotides are created by multiple tiers of ligation of shorter oligos. The disclosed methods work to extend short oligos that are attached to particles, thereby allowing one to create particles that carry large number of long sample preparation oligonucleotides without being required to synthesize those full-length molecules with a polymerase.