baber/WOPTO huggingface dataset:
Patent DK-174889-B1 (DK)
Inventor: BARTFELD DANIEL
IPC: C12N15/00
Filed: 1985-08-20
Granted: 2004-01-19
Abstract: This invention concerns a method for recovering a purified eucaryotic growth hormone or an analog thereof from a bacterial cell in which the growth hormone or analog has been produced by means of expression of a DNA sequence encoding the hormone or analog. The method involves the following steps: (a) disrupting the cell wall of the bacterial cell or fragments thereof to produce a lysate; (b) separating a precipitate containing particulate and insoluble material from the lysate; (c) preparing suspension of the separated precipitate in an appropriate buffer solution; (d) treating the suspension to effect contact between liquid and solids; (e) separating partially or completely precipitated material from the liquid-solids contacted suspension; (f) solubilizing the separated precipitate in a sufficient amount of water and adjusting the pH to a suitable alkaline pH to form a solution; (g) separating the solubilized hormone or analog from other cellular components by ultrafiltration under suitable conditions to produce an ultrafiltrate containing the hormone or analog and a retentate, and (h) treating the solubilized hormone or analog so as to concentrate the hormone or analog and thereby recover purified hormone or analog. Separations may be effected by ultrafiltration or centrifugation. Sonication as well as the ultrafiltration in step (i) may be repeated. Additionally, most of the process steps may be performed in a continuous flow and may be automated. Suitable hormone-producing bacterial cells for use in this invention include genetically modified strains of Escherichia coli. Growth hormones which can be recovered and purified using this invention include bovine, porcine, chicken, and human growth hormones, and analogs thereof.
Patent DK-174846-B1 (DK)
Inventor: MELCHERS GEORG
IPC: A01H1/02
Filed: 1989-10-06
Granted: 2003-12-22
Abstract: Male-sterile tomato plants are obtained by fusing tomato protoplasts that contain inactivated cytoplasmic elements with Solanum protoplasts containing inactivated nuclear elements, thereby to produce a plurality of fusion products, at least some of which can be regenerated into whole, male-sterile tomato plants which are useful as female parents in hybrid production.
Patent FI-102142-B1 (FI)
Inventor: SCHAEFER HANS
IPC: A61K9/16
Filed: 1989-12-19
Granted: 1998-10-30
Abstract: The invention relates to a pharmaceutical or cosmetic composition for topical application, containing, in a suitable carrier, microspheres of polymers or of fatty substances filled with at least one active product, characterized in that at least 80% of the microspheres employed have a diameter of between 3 (my)m and 10 (my)m.
Patent FI-102698-B1 (FI)
Inventor: LEWIS LYNETTE A
IPC: G01N33/53
Filed: 1990-07-11
Granted: 1999-01-29
Abstract: Use of a lithium salt, particularly lithium thiocyanate, as an agent for lysing red blood cells and denaturing hemoglobin in the performance of an immunoassay to detect the relative amount of a hemoglobin derivative in a blood sample. The method is particularly useful in the determination of hemoglobin A1c. The method provides a rapid means for releasing hemoglobin from red blood cells by lysis and for exposing the epitope that is characteristic of the A1c form. Low concentrations of the lithium salt provide rapid release and denaturation of hemoglobin without the need for dilution prior to the performance of the immunoassay.
Patent IE-47135-B1 (IE)
Title: Process for the preparation of alpha-substituted-thien-3-ylacetic acid and derivatives thereof
IPC: C07C231/12
Filed: 1978-07-21
Abstract: A process for the preparation of 3-substituted thiophenes which involves cyclisation of a novel intermediate, avoids the use of previously employed expensive starting materials. The thiophenes are useful for the preparation of penicillins and cephalosporins. The process is for the preparation of a thiophene of formula (I): where R1 represents a carboxylic acid group, or an ester or amide thereof or a nitrile group; R2 represents a group suitable for use as an α-substituent in the side-chain of a penicillin or cephalosporin; which comprises treating a compound of formula (II): wherein X represents halogen or optionally functionalised hydroxyl, Y represents halogen, hydroxyl, or alkoxy; with a source of nucleophilic sulphur under basic conditions.
Patent IE-33641-B1 (IE)
Title: Novel chrysanthemic acid esters and a process for the manufacture thereof
IPC: A01N53/10
Filed: 1969-11-19
Abstract: Cyclopropane derivatives Compounds of formula: or -CH2.C=C.CH2.C=CH where R' is alkyl and R2 R3 = H or alkyl, or R' = H and R2, R3 = alkyl, R4, R5, R6 = H, alkyl. Insecticides active against a wide variety of insects, esp. against the house-fly, particularly effective when synergised e.g. with piperonyl butoxide. LD50 orally in mice of (I) (R = 5-methyl-5-hexen-2-vinyl vinyl (i), 6-methyl-5-hepten-2-ynyl (ii) or 2.5-hexadiynyl (iii) is >1600 mg/kg. Activity against housefly is comparable so that of DDT and pyrethrum extract. Ester (i) is active against apple fly, ester (iii) is active against apple, potato and bean fly, and red spider.
[FR2025695A1]
Patent IE-55894-B1 (IE)
Title: N-imidazolyl derivatives of bicyclic compounds and process for their preparation
IPC: C07D405/04
Filed: 1983-07-04
Abstract: Compounds of the formula (I)  (I) wherein the symbol represents a single or a double bond; Z completes a single bond or is a -CH2- group; each of R1, R2, R3 and R4, which may be the same or different is (a) hydrogen; hydroxy; halogen; cyano; C1-C6 alkyl; C1-C6 alkoxy; a C2-C4 acyl or C2-C4 acylamino group; -SR', -N(R') (R''), -CH2OR', -COR or -CH2COR, wherein R is OR' or -N(R') (R'') and each of R' and R'', being the same or different, is hydrogen or C1-C6 alkyl; or (b) one of R1, R2, R3 and R4 is 5- tetrazolyl or a group selected from -COCH2OR', -CH=C(R')-COR and -X-C(R') (R'')-COR, wherein R, R' and R'' are as defined above, and X is -O-, -S-, or -NH-, and the others are as defined above under (a); one of R5 and R6 is hydrogen and the other is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, or a phenyl or pyridyl ring, wherein the phenyl or pyridyl ring is unsubstituted or substituted by one to three substituents chosen from hydroxy and C1-C4 alkoxy; or pharmaceutically acceptable salts thereof exhibit pharmaceutical activity as vasodilators or blood platelet aggregation inhibitors. Additionally, these compounds and their pharmaceutically acceptable salts are useful in the treatment of migraine, diabetic microangeopathy, rheumatoid arthritis, hypertension, peptic ulcers, osteoporosis, angina pectoris, atherosclerosis and dislipidaemies.
Patent IE-35885-B1 (IE)
Title: Process for polymerizing cyclo-olefins to polyalkenamers
IPC: C08F10/00
Filed: 1971-12-10
Abstract: 1363119 Polymerization of cycloolefins MONTECATINI EDISON SpA 14 Dec 1971 [16 Dec 1970] 57972/71 Heading C3P Polyalkenamers are prepared by polymerizing cycloolefins (excluding cyclohexene) in the presence of a catalyst comprising (1) a W, Mo or Ta compound, (2) a hydride, halide or organometallic compound of a metal (including B and Si) of Groups I, II, IIIa or IVa of the Mendeleef Periodic Table and (3) CO 2 or a compound (e.g. a carboxylic acid or salt thereof, a betaketo carboxylic acid or sodium carbamate) which generates CO 2 under the polymerization conditions. The polymerization may be carried out in bulk or in the presence of a solvent. In the examples cyclopentene and cyclooctene are polymerized in bulk and cyclopentene is polymerized in anhydrous cyclohexane using as catalyst one of WCl 6 , MOCl 5 , TaCl 5 or WOCl 4 which has been contacted with gaseous or frozen CO 2 and one of EtAlCl 2 , Et 2 AlCl, Et 3 Al, AlCl 3 , di-n-hexylzinc, tri-n-hexyltin or n-butyl lithium, the polymerization is terminated by the addition of HCl and methanol and phenyl-beta-naphthylamine is added to the product polymer which may be vulcanized.
[GB1363119A]
Patent IE-47242-B1 (IE)
Title: Manufacture of fibres by means of gaseous currents with economy of energy
IPC: C03B37/06
Filed: 1978-08-17
Abstract: The process of manufacture of fibres from a mineral thermoplastic substance employs a main gas stream (27) and a secondary gas jet (29). The section of the secondary jet is smaller than that of the main stream but the kinetic energy per unit volume of the secondary jet is higher than that of the main stream. The secondary jet is directed transversely to the main stream and enters it to create a zone of interaction (Z) which includes turbulent streams. A lace of ductile substance (34) is brought into this zone by the secondary jet. In the interaction zone the streams of gas contain oxidising fuel components introduced from the duct (35) by the nozzle (36) in proportions which result in a combustible mixture. The lace of ductile substance is brought into the zone (Z) at a temperature which is at least equal to the ignition temperature of the mixture. The process is employed especially for making fibres from glass.
Patent IE-57625-B1 (IE)
Title: Nail polish remover
IPC: A61K8/00
Filed: 1984-07-03
Abstract: The fingernail water removal activity of aquenous acetone based polish removers is lowered by incorporating therein an amine salt of an anionic amidized hydrolyzed collagen, preferably in combination with an acid addition salt of aminized trialkylamine cationic surfactant.
Patent IE-38867-B1 (IE)
Title: Motor-driven display device
IPC: G09F19/10
Filed: 1973-10-11
Abstract: 1388328 Moving displays MARDON SON & HALL Ltd 10 Get 1973 [21 Get 1972] 48576/72 Heading G5C In a moving display device, the lid 12 of a box 11 containing imitation cigarettes 20 is respectively raised and a cigarette 21 extended by means of mechanism driven by motors 13 through shaft 14. Crank-arm 16 actuates the lid through rod 17 and lug 18, while cam 15 raises and lowers hollow piston 19 on which cigarette 21 stands. Cigarette 21 may be screw-threaded to provide an added rotary motion.
[GB1388328A]
Patent IE-63976-B1 (IE)
Title: Alginate gels
Inventor: BENNETT ALEXANDER N
IPC: A23L21/10
Filed: 1989-06-12
Abstract: This invention relates to calcium alginate gels and in particular to encapsulated calcium salts dispersed in soluble alginate systems. In this way, homogeneous calcium alginate gels can be prepared without precipitation of the alginate as fibrous calcium alginate. These gels are useful in a variety of food products.
Patent IE-62587-B1 (IE)
Title: Composition for the treatment of erectile dysfunction
Inventor: KOCK NILS G
IPC: A61K31/5575
Filed: 1989-08-21
Abstract: Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.
Patent IE-58402-B1 (IE)
Title: Color stabilized hydrogel dressing and process
IPC: A61K47/00
Filed: 1986-10-24
Abstract: A polyvinylpyrrolidone(PVP)/Silver Sulfadiazine (SSD) hydrogel dressing in which the gel is formed by the use of electron beam (E-Beam) radiation to cross-link the polyvinylpyrrolidone (PVP); in which the color of the hydrogel dressing has been stabilized by the addition thereto of magnesium trisilicate and, optionally but preferably, also hydrogen peroxide and/or polyacrylic acid is disclosed; and also the process of stabilizing the color by adding magnesium trisilicate, to a water dispersion of PVP and SSD before it is exposed to E-Beam radiation is disclosed.
Patent IE-52220-B1 (IE)
Title: Novel benzo(b)thiophenes,benzo(b)furans,thiochromans and chromans,processes for their preparation and antimicrobial compositions containing them
IPC: A61K31/38
Filed: 1981-12-11
Abstract: Compounds of the formula 
<CHEM>
 wherein n is 0 or an integer from 1 to 4;
 p is 0 or 1;
 q is 0, 1 or 2,
 R and R<1> are independently hydrogen or halogen atoms, or lower alkyl, halolower alkyl, nitro or NR<2>R<3> groups, wherein R<2> and R<3> are independently hydrogen atoms or lower alkyl groups; or R and R<1> together in adjacent positions complete a fused saturated or unsaturated carbocyclic ring that may contain 5 to 7 carbon atoms;
 X is an oxygen or sulfur atom or a sulphinyl or sulphonyl group;
 Y is an imidazolyl or 1,2,4-triazolyl group, either of which may be substituted by a lower alkyl or aryl group, wherein said aryl group is a phenyl, halophenyl or lower alkyl phenyl group;
 Z is an alkyl, alkenyl, alkynyl, cycloalkyl or heterocyclic aromatic group, which may have at least one substituent selected from halogens atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy, phenyl and N-(N min -lower alkanoyl-piperazinyl) groups, provided that, when n is 0, Z is not 1-alkynyl; and, when n is 1 to 4, Z can also be an alkoxy, alkylthio, aryl, aryloxy or arylthio group, or an aryl, aryloxy or arylthio group having substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy and N-(N min -lower alkanoyl-piperazinyl)- groups;
 where the term "lower" indicates groups having 1 to 6 carbon atoms; and the broken line indicates a single or double bond, with the proviso that it is a double bond only when p is 0 and X is a sulfur atom;
 and the acid addition salts thereof;
 have antimicrobial, in particular antifungal, antibacterial and antiprotozoal activity. Compositions, especially pharmaceutical compositions, containing them and processes for their preparation are also disclosed.
Patent IE-62543-B1 (IE)
Title: Flow control device
Inventor: WINNINGTON TERENCE LESLIE
IPC: G05D7/06
Filed: 1989-09-19
Abstract: A solenoid valve (27) has an energising coil (40) for a shuttle (41) arranged to control movement of a valve member (28) relative to a valve seating (25) to open and close an outlet port (24). The shuttle (41) includes a permanent magnet (42) arranged to generate a repulsion force when the coil (40) is energised for displacing the shuttle (41) against the biassing of a return spring (48) to move the valve member (28) away from the valve seating (25) to open the outlet port (24), and displacement of the shuttle (41) is adjustable by varying the energising voltage to provide a range of open positions of the valve member (28) for controlling the flow rate. The valve (27) is preferably incorporated in a flow control device (1) including a flowmeter (9) for monitoring the flow rate and generating a signal related to the flow rate for adjusting the energising voltage to maintain a selected flow rate substantially constant.
Patent IE-52235-B1 (IE)
Title: Pentacyclic pyrazinoquinoline derivatives
IPC: C07D267/20
Filed: 1981-12-30
Abstract: Compounds of formula (I): wherein: X is CH2, 0, S or NR wherein R is hydrogen or C1-4 alkyl; Y and Z are independently selected from hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R1 is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-4 alkyl any of which phenyl moieties may be substituted by one or more of C1-6 alkyl, C1-6 alkoxy, halogen or CF3; R2 is hydrogen, OH, C1-6 alkoxy, phenyl-C1-4 alkoxy, C1-7 acyloxy or NR4R5 wherein R4 and R5 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen and R5 is OH or C1-4 alkoxy; or R4 and R5 together form C3-6 polymethylene optionally interrupted by 0 or NR6 where R6 is hydrogen or C1-4 alkyl; or together with R, forms an oxo group or =NOR7 wherein R7 is hydrogen or C1-6 alkyl; and R3 is hydrogen or C1-6 alkyl have useful pharmacological activity, processes for their preparation and their use.
Patent IE-80788-B1 (IE)
Title: Smoking article
Inventor: SENSABAUGH ANDREW JACKSON JR
IPC: A24D1/22
Filed: 1985-08-20
Abstract: The cigarette has a carbonaceous fuel element. A separate aerosol generator has a substrate bearing an aerosol forming material. The fuel element and substrate are arranged in a conductive relationship, so that the heat-stable substrate receives conductive heat transfer throughout the burning time of the fuel element. The fuel element is less than 30mm in length, with a density of at least 5 g/cc. An insulation material can surround part of the fuel element. The insulation is resilient and at least 15 mm thick. The cigarette also has a mouthpiece.
Patent LU-101607-B1 (LU)
Title: Surgical tool for force measurement and distance measurement
Inventor: JI BING
IPC: A61B17/58
Filed: 2020-01-27
Granted: 2020-05-27
Abstract: The present invention discloses a surgical tool for force measurement and distance measurement, which solves the problems in the prior art that the depth of perforation is difficult to grasp and the stress is difficult to measure, can detect the depth of the surgical tool in real time, can also detect the magnitude of force on the surgical tool in real time, and can meet different types of operation needs by replacing a tool tip. According to the technical solution, the surgical tool comprises a shank, a tool bar, and a tool bit, wherein one end of the tool bar is detachably connected to the shank, and the other end of the tool bar is detachably connected to the tool bit; a transparent housing is mounted on the outside of the tool bar, and a lamp is fixed on one side of the tool bar; wherein the tool bar comprises a thrust mechanism, and the thrust mechanism is connected to a force measuring mechanism and is capable of driving the force measuring mechanism to move.
Patent LU-501592-B1 (LU)
Title: Preparation method of butyl reclaimed rubber by reducing temperature and environmental protection desulfurization and its application in airtight products
Inventor: WANG YANQIU
IPC: C08J11/26
Filed: 2022-03-04
Granted: 2022-09-05
Abstract: The invention discloses a preparation method of butyl reclaimed rubber by reducing temperature and environmental protection desulfurization and its application in airtight products. The method adopts an open mill to desulfurize at low temperature Butyl rubber particles are adjusted to 0.1 mm in the open mill roller distance, evenly added into the open mill at the roller temperature of 25-30 degree Celsius, and thinly passed several times until the roller is wrapped for about 5 minutes. The compound regeneration activator is added into the butyl rubber compound, and then the paraffin oil is added into the rubber compound until the rubber compound is bright and clean for 5 min; the mixed rubber is conveyed to an open mill with a roller distance of 1.0 mm and a regeneration temperature of 90 degree Celsius, and refine the rubber compound until it is bright at a roller temperature of 40 degree Celsius.
Patent LU-503283-B1 (LU)
Title: Smart lighting device based on smart city construction
Inventor: WU HAITAO
IPC: F21S8/08
Filed: 2022-12-30
Granted: 2023-06-30
Abstract: The present invention relates to a smart lighting device based on smart city construction, which comprises a support rod, a lamp body and a cleaning box; the lamp body is fixedly connected to an upper end of the support rod, a left side and a right side of the lamp body are both fixed with a cleaning box, a bulkhead is fixed inside the lamp body, a sliding plate is provided between the bulkhead and a heat sink, U-shaped tubes are evenly distributed in the cleaning box; in an initial state, a second storage tank is blocked by a sliding cover to prevent a desiccant in the second storage tank from losing efficacy after being exposed to the air for a long time, which improves a service life of the desiccant in the second storage tank, and reduces an use cost.
Patent NO-304292-B1 (NO)
Inventor: PYRET THOMAS W
IPC: A61D7/00
Filed: 1991-07-18
Abstract: An applicator for administering a veterinary pharmacological composition comprises a container having a cannula extending therefrom and a two-piece cap for releasably covering the cannula. The cap has an internal seal for sealing the cannula against leakage and contamination.
Patent NO-303481-B1 (NO)
Inventor: ROESSLING GEORG
IPC: A61K49/04
Filed: 1991-12-18
Abstract: Described is a process for the preparation of aqueous liposome suspensions containing active substances, the suspensions being prepared from a solution of a liposome-forming substance, or mixture of such substances, in a lower alcohol with a maximum of three carbon atoms and an aqueous phase, the active ingredients being dissolved or suspended in the lipid solution and/or the aqueous phase. The process is characterized in that the aqueous phase is incorporated, by mixing, in the alcoholic solution and the lower alcohol removed by vacuum distillation and, if necessary, the liposome suspension freeze-dried.
Patent NO-300101-B1 (NO)
Inventor: DAIRE ERICK
IPC: C08F4/44
Filed: 1992-08-27
Abstract: The present invention relates to an ethylene polymerisation process carried out with the aid of a catalyst system of the Ziegler-Natta type comprising a titanium based catalyst. The process is performed such that the ethylene polymerisation takes place in the presence of a halogenated hydrocarbon compound. In most of the cases the halogenated hydrocarbon compound is used in a quantity such that the molar ratio of the halogenated hydrocarbon compound to titanium of the catalyst is in the range from 0.01 to 1.8. Preferably the halogenated hydrocarbon compound is chloroform or trichloro-1,1,1, ethane. <IMAGE>
Patent NO-306946-B1 (NO)
Inventor: BOGESO KLAUS
IPC: A61P25/00
Filed: 1994-10-27
Abstract: Trans isomers of 1-piperazino-1,2-dihydroindene compounds having formula (I),    <IMAGE>  I  wherein X and Y are hydrogen, halogen, trifluoromethyl, alkyl, alkylthio, trifluoromethylthio, alkoxy, hydroxy, alkylsulfonyl, amino, alkylamino, nitro or cyano; Ar is a phenyl, thienyl or furyl group, each optionally substituted; R1 is hydrogen, or optionally hydroxy substituted alkyl, alkenyl, cycloalkyl or cycloalkylalkyl; R2 is alkyl, alkenyl, cycloalkyl, or cycloalkylalkyl; or R1 and R2 together form a 5 to 7-membered heterocyclic ring fused with the piperazine ring, which ring may be substituted with hydroxy; R3 is hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl; or R2 and R3 together form a 3 to 7-membered carbocyclic ring which is spiro-fused to the piperazine ring; and R4 is hydrogen or alkyl. The compounds of the invention have potent antagonist action on dopamine D1 receptors and are useful in the treatment of diseases of the central nervous system, such as psychoses, schizophrenia (positive as well as negative symptoms), anxiety, depression, sleep disturbances, migraine, Parkinson's disease or cocaine abuse.
Patent NO-302047-B1 (NO)
Inventor: VATNE PER
IPC: E21B19/086
Filed: 1995-12-22
Abstract: An apparatus for a derrick, comprising two or more hydraulic piston/cylinder arrangements (10, 11) for raising and lowering a yoke (8) which travels on guide rails (7) in the derrick itself and a hydraulic system (30) for the operation of piston/cylinder arrangements (10, 11), where the hydraulic system has various modes of operation, normal raising or lowering of the yoke (i), use of the differential area of the piston (21) for rapid lowering or raising of the yoke (8) and, optionally, a combination of these with extra pressure provided from the accumulators (39).
Patent NO-308741-B1 (NO)
Inventor: KOJIMA KOICHI
IPC: A61K31/42
Filed: 1997-02-27
Abstract: The isoxazole derivative having the following general formula: <CHEM> Äwherein R<1> represents a hydrogen atom; halogen atom; alkyl group; alkoxy group; hydroxyl group; alkylthio group; amino group; alkanoyl group; alkanoylamino group; alkanoyloxy group; alkoxycarbonyl group; carboxy group; (alkylthio)thiocarbonyl group; carbamoyl group; nitro group; or cyano group; R<2> represents an amino group; m represents an integer of from 1 to 3; n represents an integer of from 1 to 6; ring A represents a phenyl ring, a naphthyl ring or an aromatic heterocycle; X represents an oxygen atom or a sulfur atomÜ has an excellent monoamine oxidase inhibitory activity, and is useful as a therapeutic agent or a preventive agent against neuropathies (Parkinson's disease) and the like.