Patent SG-11201807279Q-A (SG)
Title: Binding proteins and methods of use thereof
Inventor: SHEN WENYAN
IPC: C12Q1/68
Filed: 2017-03-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property ' Organization 11111111011110111010101111101011111011101011111011101111001101111101111011111 International Bureau (10) International Publication Number (43) International Publication Date ..... .......•:;.1 WO 2017/172260 Al 5 October 2017 (05.10.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 39/395 (2006.01) CO7K 14/475 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 16/18 (2006.01) C12Q 1/68 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/020654 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 3 March 2017 (03.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/316,516 31 March 2016 (31.03.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: NGM BIOPARMACEUTICALS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 333 Oyster Point Boulevard, South San Fran- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, cisco, CA 94080 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: SHEN, Wenyan; 333 Oyster Point Boulevard DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, South San Francisco, CA 94080 (US). TANG, Jie; 333 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Oyster Point Boulevard, South San Francisco, CA 94080 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (US). WANG, Yan; 333 Oyster Point Boulevard, South GW, KM, ML, MR, NE, SN, TD, TG). San Francisco, CA 94080 (US). MATERN, Hugo; 333 Published: Oyster Point Boulevard, South San Francisco, CA 94080 (US) — with international search report (Art. 21(3)) (74) — with sequence listing part of description (Rule 5.2(a)) Agents: McNICHOLAS, Janet, M. et al.; Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (54) Title: BINDING PROTEINS AND METHODS OF USE THEREOF FIG. 1 Human -MIVFI FLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCK Chimpanzee -MIVFIFIAMGLSLENEYTSQTNNCTYLREQCLADANGCKHAWRVMEDACNDSDPGDPCK Cynomolgus -FVVVVI QALGLSLENEYTSQTNNCTYLREQCLHDANGCKHAWRIMEDACNDSDPGDPCK Giant Panda -MVVFI FLAVALCLENESTSETIDCTYLREQCLRDANGCKHAWRIMEDSCNVSEPGNPCK Dog -MIVFIFLAMVLCLENESTSQTIDCTHLREQCLSDADGCKHAWRIMEYSCNVSVPGNPCK Cat -SVLIVI SAMVLCLENESTSQTIDCTYLREQCLSDTNGCKLAWRKMEDSCNVSDPGNPCK Pig - SVIAVLQAVGLYLENESTSQTTDCTYLRELCLNDTDGCKQAWRIMEDACNVSDPGNTCQ Bovine -PLIVVIQAVGLCLN-KSASQTTDCTYLRELCLSDADGCKHAWRIMEDACNVS--GNTCQ Mouse -MLVFIFLAVTLSSENESSSQTNDCAHLIQKCLIDANGCEQSWRSMEDTCLT--PGDSCK Rat -MLVFIFIAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRSMEDACLV--SGDSCK Chinese Hamster Platypus MKHYFLEVVIALGEKCESASLTTGCLHLRKQCVSAMDGCESAWAVIEDVCNVS--GIENCT * ** * * * * * Human MRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKED-KFKWNLT Chimpanzee MRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKED-KFKWNLT Cynomolgus MNNSSYCNLSIOYLVESNERFKECLCTDDFYCTVNKLLGKECVNKSDNMRED-KFKWNLT 11 Giant Panda MKDSSKCNLSIQSLVESNFQFEDCLCTDNLYCTINKLLGEQCINESGNVKEDNQSKWNLT Dog MKDSSNCNLSIQSLVENNFQFEDCLCTDNIYCTINKLLGEQCMNESDNMKEDNQYKWNLT Cat MKDSSNCNLSIQSLVENNFQFEDCLCTGNLHCTINKLLGKKCINESDNMKEDNQSKWNLT Pig MKDSSSCNQSIQSLAESNFQFKDCLCSDDLYCTVNNLIGKKCTNESDNMKEDGVFKRNLT C:= Bovine MKNSSSCGLSIQSLVESNLQFKDCLCFDDLYCTFNKLLGKKCINESDNIKEDNKYKWNLT V::, N Mouse Rat INNSLHCNLSIQALVEKNFQFKECLCMDDLHCTVNKLFGKKCTNKTDNMEKDNKDKWNLT INNPLPCNLSIQSLVEKBFQFKGCLCTDDLHCTVNKIFGKKCTNKTDSMKKDNKYKRNLT Chinese Hamster N Platypus MKESLNCNLSIQLLADRYPAFKDCLCAEDISCSATNFLGRKCIIKTENEHKDKNIKSLWN IN * *** * * *** r * * 11 ..„.... IN 1-1 (57) : The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha 0 Like el (GFRAL) protein, including human GFRAL protein, and methods of their use. 0