baber/WOPTO huggingface dataset:
Patent EP-0753068-B1 (EP)
Inventor: CURIEL DAVID T
IPC: C12P21/02
Filed: 1995-03-28
Granted: 2005-11-09
Abstract: On a modifié génétiquement la protéine fibre d'adénovirus en l'attachant au niveau de l'extrémité carboxyle d'un segment de liaison peptidique, d'une longueur pouvant atteindre, de préférence, 26 acides aminés, qui forme une spirale aléatoire et peut être utilisé pour fixer un ligand de non-adénovirus modifiant la spécificité de liaison de la protéine fibre. Les ligands peuvent être des peptides qui sont liés sélectivement par une cellule ciblée de sorte que la protéine fibre modifiée soit intériorisée par l'endocytose induite par un récepteur, et des peptides pouvant agir comme un agent de couplage universel pour, par exemple, la biotine ou la streptavidine. Le segment de liaison est conçu pour ne pas gêner la trimérisation normale de la protéine fibre, supprimer l'empêchement stérique de la liaison de ladite protéine sur une cellule ciblée, et pour servir de site pour l'introduction d'une nouvelle séquence peptidique. On prépare la protéine fibre modifiée par manipulation génétique de la séquence nucléotidique codant cette dernière, en ajoutant une nouvelle séquence, au niveau de la région codant la queue carboxyle, qui code le segment de liaison et le ligand. L'extrémité terminale N n'est pas modifiée dans le mode préféré de réalisation, bien qu'il soit souhaitable, dans certains modes, d'inhiber la capture par le noyau de la protéine fibre, par suppression des signaux de ciblage nucléaires. Ladite protéine fibre modifiée peut être utilisée comme partie intégrante d'un adénovirus de recombinaison en thérapie génique.
Patent EP-0764231-B1 (EP)
Title: Device for securing light weight articles
Inventor: WUETHRICH HEINZ ERWIN
IPC: E04B1/38
Filed: 1995-05-04
Granted: 1998-01-07
Abstract: The device (1) proposed for mounting light articles on walls fitted with plastic insulation has a squat cylindrical main body (2) whose upper portion, facing outwards when mounted, has a honeycomb structure (7) and whose lower surface (3) has tooth-shaped lugs (4) projecting out from it. The main body (2) also has several air-circulation holes (11) passing through it. The honeycomb structure (7) is made up of a multiplicity of recesses (8) which do not pass right through the main body, the recesses extending in at right angles to the upper surface (6) of the main body and being open at said surface. The mounting device (1) is inserted in outwards-facing holes in the outer surface of the insulation layer so that the honeycomb structure (7) is outside and the lugs (4) inside. The lugs (4) penetrate into the insulation layer. When mounted, the device (1) lies under the plaster and a netlike reinforcement.
Patent EP-0779076-B1 (EP)
Inventor: DEIGIN VLADISLAV ISAKOVICH
IPC: A61P17/14
Filed: 1995-06-27
Granted: 2005-03-09
Abstract: The invention is a peptide of general formula (I) X-Tyr-Y-Phe-Z-A, wherein: X represents H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, Har, D-Har, Cyt, D-Cyt; Y represents D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Har, D-Arg, D-His, D-Asp, D-Glu, D- beta -Ala, D-Orn; Z represents Ala, D-Ala, Val, D-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gly, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu,  beta -Ala, D- beta -Ala, Orn, D-Orn; and A represents OH or a substituted amide (C1-C3). According to the invention, the proposed peptide of general formula (I) is obtained by the gradual construction of a peptide chain, starting from C-terminated amino acide Z, in the form of a substituted amide or carboxyl-protected group, by addition using the method of activated ethers or mixed anhydrides of a successive N-protected amino acid; the N-protective group is split off and the successive N-protected amino acid is re-added to produce a tetra- or pentapeptide which is unblocked in the presence of a palladium catalyst, and the target product is separated out. The proposed peptide and a compound based on it can be used as an agent with pronounced opiate-like properties and also has anabolic properties which increase body weight as well as promoting activity in the growing zones and development of the epidermal layer including the hair. The bio-stimulating properties of the claimed peptide are also evident in the healing of wounds and repair processes.
Patent EP-0722281-B1 (EP)
Inventor: HEINTKE HANS-EBERHARDT
IPC: B26B19/38
Filed: 1995-07-13
Granted: 1998-01-28
Abstract: PCT No. PCT/EP95/02739 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Jul. 13, 1995 PCT Pub. No. WO96/05751 PCT Pub. Date Feb. 29, 1996The present invention relates to a depilating device with a multiple-shell housing (2), which a user can hold in the hand, a motor (13) accommodated in the housing (2), and a gear (14) to drive a rotary cylinder (8) which is preferably provided in a housing part (7) that is adapted to be uncoupled from the housing (2). The mechanically operated component parts, more particularly motor (13), gear (14), and rotary cylinder (8) with the housing part (8) in which it is incorporated, form an assembly unit (15) which is retained in the housing (2). Vibration absorbing elements (16, 17, 18) are provided at the points of connection between the assembly unit (15) and the housing (2).
Patent EP-0761832-B1 (EP)
Inventor: PONIATOWSKI MANFRED DR
IPC: C22C5/04
Filed: 1996-06-19
Granted: 1999-12-22
Abstract: A heat-resistant platinum material with more than 99.5% by weight platinum, with high long-term creep resistance and low grain growth at high temperature contains 0.1 to 0.35% by weight zirconium and/or zirconium oxide and 0.002 to 0.02% by weight boron and/or boron oxide.
Patent EP-0742097-B1 (EP)
Inventor: ROBBEN PETRUS A M
IPC: B32B1/08
Filed: 1996-04-29
Granted: 2002-11-27
Abstract: Multilayer tubes and sheets comprise 3 layers in which the middle layer comprises a polymer selected from (a) terpolymers of ethylene, maleic anhydride and CH2=CHCOOR, where R = H, Me, Et or C4H9, and (b) opt. modified copolymers of ethylene and ethyl acrylate.
Patent EP-0775474-B1 (EP)
Inventor: O'CONNOR JOHN J
IPC: G02C7/04
Filed: 1996-11-26
Granted: 2003-05-14
Abstract: A system for staking a haptic to an optic to form an intraocular lens using a laser beam operating near the infrared range with a coaxial aiming laser beam operating in the visible range. A portion of the haptic is inserted into the optic through a radial bore and is exposed through an axial bore spanning from the optic upper surface to the radial bore. The coaxial laser beams are collimated and then focused using a microscope objective through the axial bores, onto the exposed haptic. Aiming of the coaxial beams onto the optic and haptic is aided by the use of a magnifying CCD camera. The coaxial lasers, which are typically focused to a minor diameter which is greater than or equal to the inner diameter of the axial bore, make contact with the exposed haptic. Consequently, the haptic is melted and is then allowed to cool, coalescing into a bead staking the haptic to the optic. <IMAGE>
Patent EP-0773571-B1 (EP)
Inventor: SCHWARZ WILLY
IPC: H01H71/32
Filed: 1996-09-06
Granted: 2002-10-30
Abstract: The FI-switch release has a housing with a pin Ä4Ü that is displaced axially to operate contacts to operate an isolating switch. The actuator has an armature Ä8Ü that is supported on leaf spring element Ä5Ü and is normally in a position where the armature sits against pole surfaces Ä30Ü in a plate . On the underside of the plate is a yoke Ä16 and permanent magnets Ä17Ü, together with a coil Ä10Ü. When the coil current is sufficient a magnetic field is generated and the armature responds to displace the pin.
Patent EP-0840900-B1 (EP)
Inventor: GRUENING ULRIKE
IPC: G02B6/136
Filed: 1996-07-11
Granted: 1999-11-10
Abstract: L'invention concerne une structure optique convenant comme guide de lumière ou cavité et comportant un support (1) avec une structure réticulaire (2) présentant une bande interdite photonique et une région lacunaire (5). Cette structure réticulaire (2) comprend des pores (4) qui sont disposés en un réseau périodique et possèdent une section de striction. Ce réseau périodique est interrompu dans la région lacunaire. La structure optique peut être produite par attaque électrochimique de silicium.
Patent EP-0847240-B1 (EP)
Inventor: GREFF RICHARD J
IPC: A61K31/745
Filed: 1996-07-29
Granted: 2003-03-26
Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10  mu m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.
Patent EP-0792113-B1 (EP)
Inventor: LULOFS KLAAS JACOB
IPC: A45D20/00
Filed: 1996-09-02
Granted: 2001-12-05
Abstract: A hair-care appliance measures the moistness of the hair by measuring the resistance (Rx) of the hair between measurement electrodes (14A/14B). The hair resistance (Rx) is included in a T network comprising a first resistor (20) driven by a voltage source (28) and a second resistor (24). The signal current (Is) through the second resistor is measured and converted into a measurement signal (MS) by a converter (30). As a result of the use of the T network a comparatively large resistance variation of the hair resistance (Rx) is required for a given amplitude variation in the signal current (Is). This allows measurements over a wider resistance range while the resolution is maintained.
Patent EP-0790979-B1 (EP)
Inventor: MAURO MARINA
IPC: C07C231/24
Filed: 1996-08-02
Granted: 1999-12-08
Abstract: This invention refers to a process for the crystallization from water of S-N,N'-bis[2-hydroxy-1(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide known as Iopamidol. According to the process of this invention, a crystalline anhydrous Iopamidol in accordance with pharmacopeia standards can be obtained.
Patent EP-0850070-B1 (EP)
Inventor: ZHAO QIUYAN
IPC: A61K47/48
Filed: 1996-08-19
Granted: 2003-01-22
Abstract: The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
Patent EP-0796500-B1 (EP)
Inventor: GENTSCH DIETMAR
IPC: H01H1/02
Filed: 1996-10-02
Granted: 2001-09-12
Abstract: L'invention concerne un procédé de fabrication d'une pièce de contact constituée d'un corps de base réalisé dans un matériau (premier matériau) bon conducteur l'électricité et d'une couche de contact réalisée dans un matériau (second matériau) moins bon conducteur d'électricité et résistant à la combustion due à l'arc électrique. La couche de contact présente une structure frittée imprégnée par le matériau du corps de base. Le corps de base et la structure frittée sont superposés dans un moule en forme de cuvette où ils sont chauffés à une température supérieure à la température de fusion du premier matériau mais inférieure à la température de fusion du second matériau de telle façon que le premier matériau fonde et pénètre dans la structure frittée. La structure frittée peut en l'occurrence être produite en répandant sur le premier matériau le second matériau sous forme pulvérulente et ensuite en procédant à un frittage, selon un procédé de dégazage, à une température inférieure à la température de fusion du premier matériau. Il est également possible de fabriquer préalablement la structure frittée et de poser une ébauche de compact sur le corps de base.
Patent EP-0870022-B1 (EP)
Title: Immunostimulatory composition and method
Inventor: LAUS REINER
IPC: A61K35/14
Filed: 1996-12-23
Granted: 2007-02-07
Abstract: Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by contact with a polypeptide complex constructed by joining together a dendritic cell-binding protein and a polypeptide antigen. Also disclosed are expression vectors and systems for producing the polypeptide complexes.
Patent EP-0797270-B1 (EP)
Inventor: STOLLBURGES MARTIN
IPC: H01R9/26
Filed: 1997-03-07
Granted: 2002-07-10
Abstract: The terminal is assembled from two mutually rotatable bodies (1) each having a lateral slot (2;3), a tapered top opening (4), and a recess (5;6) below the axis of rotation (7) for a leaf spring (8). When the assembly is complete a lateral face is formed between the two top openings. To rotate the bodies and thereby to vary the apertures of the slots, a screwdriver bit (12) is inserted into the top openings. This action enables the slots to accept and grip a busbar (11) and a conductor rail (10) respectively.
Patent EP-0792589-B1 (EP)
Inventor: GONZE MICHEL HENRI ANDRE
IPC: A23L33/20
Filed: 1997-02-24
Granted: 2001-10-17
Abstract: The present invention describes the preservation of sweetness and taste-quality in aspartame-containing calorie-reduced soft drinks. The taste and sweetness are preserved after prolonged storage due to the addition of between 0.1 and 5 (w/v) erythritol. The preservation of the quality is especially apparent in soft drinks having an acidic or slightly acidic pH.
Patent EP-0811633-B1 (EP)
Inventor: KETTLITZ BERND WOLFGANG
IPC: C08B31/18
Filed: 1997-06-03
Granted: 2002-10-16
Abstract: The present invention relates to heat stable high viscosity starches. The starches of the present invention are obtained by reacting high viscosity starch with activated chlorine under alkaline conditions. The starches of the present invention are used to replace viscosity stable starches obtained by conventional chemical cross-bonding.
Patent EP-0821869-B1 (EP)
Inventor: LAWSON IAN
IPC: A01D34/63
Filed: 1997-08-01
Granted: 2002-01-23
Abstract: A lawnmover comprises a deck defining a cutting chamber, the deck including an aperture for passage of cut grass from the cutting chamber, a cutter blade rotatable within the cutting chamber about a substantially vertical axis, a grass collection receptacle including a first air-permeable region and a first inlet for entry of the cut grass from the cutting chamber, and an air moving device for drawing air from the grass collection receptacle via the first air-permeable region, and for directing the so-drawn air into the cutting chamber. The resultant first air flow serves to entrain cut grass within the cutting chamber and to convey said entrained grass into the grass collection receptacle via the aperture and the first inlet. A second air inlet, which is disposed in the region of the first inlet, permits entry of a second stream of air into the receptacle. The second stream of secondary air serves to complement the first air flow through the receptacle, and to assist in deflecting the cut grass entrained in the first air flow into the interior of the receptacle. <IMAGE>
Patent EP-0843237-B1 (EP)
Inventor: OHTA TAKATOSHI
IPC: H04N1/46
Filed: 1997-11-06
Granted: 2004-05-06
Abstract: In case of managing image data among plural image processing apparatuses, an object of the present invention is to suppress or restrain, as much as possible, that the image data is illegally or unfairly used. In order to achieve the object, e.g., it is provided an image processing apparatus which is connected to an external apparatus being an output destination of the image data, the image processing apparatus comprises an input means for inputting the image data representing an image, an addition means for adding additional information capable of specifying the external apparatus to the image data inputted by the input means, in a state that the additional information is difficult to be perceived by human eyes, and an output means for outputting the image data to which the additional information was added by the addition means, to the external apparatus. <IMAGE>   <IMAGE>   <IMAGE>
Patent EP-0873190-B1 (EP)
Inventor: NASCIMENTO PEDRO
IPC: C07B61/00
Filed: 1997-01-10
Granted: 1999-12-08
Abstract: An alkylation catalyst including a least one porous refractory metal oxide with at least one halogen on the surface thereof. The catalyst contains 0.005-1 wt % of at least one metal from groups IA and IIA of the periodic table of the elements and is particularly useful in an isobutane alkylation method using light olefins.
Patent EP-0930862-B1 (EP)
Inventor: RAIDEL MARIA
IPC: A61F13/15
Filed: 1997-09-19
Granted: 2002-07-17
Abstract: L'invention concerne un article absorbant (10), en particulier une serviette périodique, ayant la structure suivante: une couche inférieure imperméable au liquide (12), tournée vers le corps lors de l'usage de l'article absorbant; une couche d'accumulation primaire (14) disposée au-dessus de la couche imperméable au liquide (12); une couche d'accumulation secondaire (20) disposée au-dessus de la couche d'accumulation primaire (14); une couche de compensation (32) disposée au-dessus de la couche d'accumulation secondaire (20); une couche de recouvrement (34) disposée au-dessus de la couche de compensation (32) et présentant une ouverture centrale (36); et une couche supérieure perméable au liquide (40), tournée vers le corps lors de l'usage dudit article absorbant.
Patent EP-0888319-B1 (EP)
Title: Derives de 1,2,3,4-tetrahydronaphthalene substitues
Inventor: BERG STEFAN
IPC: A61K31/495
Filed: 1997-03-20
Granted: 2003-01-29
Abstract: Nouveaux dérivés de 1,2,3,4-tétrahydronaphthalène substitués par pipéridinyle ou pipérazinyle, de la formule (I). Dans cette formule, X est N ou CH; Y est NR2CH2, CH2-NR2, NR2-CO, CO-NR2 ou NR2SO2; R1 est H, C1-C6 alkyle ou C3-C6 cycloalkyle; R3 est C1-C6 alkyle, C3-C6 cycloalkyle ou (CH2)n-aryle, où aryle est phényle ou un cycle hétéroaromatique renfermant un ou deux hétéroatomes choisis parmi N, O et S et pouvant être mono- ou di-substitués; n est un nombre de 0 à 4; en tant qu'énantiomère (R), énantiomère (S) ou mélange racémique sous forme de base libre, de sel pharmaceutiquement acceptable ou d'hydrate de ce sel; formulation pharmaceutique renfermant ces composés, utilisation de ces composés pour le traitement des désordres à médiation de 5-hydroxytryptamine, procédés d'élaboration de ces composés et intermédiaires de ceux-ci.
Patent EP-0892751-B1 (EP)
Inventor: JENSEN JAN
IPC: B65G39/00
Filed: 1997-04-10
Granted: 2000-01-05
Abstract: PCT No. PCT/EP97/01802 Sec. 371 Date Aug. 6, 1999 Sec. 102(e) Date Aug. 6, 1999 PCT Filed Apr. 10, 1997 PCT Pub. No. WO97/37913 PCT Pub. Date Oct. 16, 1997The invention relates to an electrically driven drum motor 1 comprising a substantially cylindrical drum 2 of noncorroding material, especially in the form of an electrically driven conveyer roller, said drum 2 having annular end edges 12 and being connected with two circular end caps 14, 15 to define, together with these, an internal space to receive an electric motor 7, said end caps 14, 15 being provided with a central opening 18 for a rigid shaft 6 for the drum motor 1, which is characterized in that each end cap 14, 15 is firmly connected with an external, separate jacket 30 of noncorroding material, especially stainless steel or plastic, said jacket 30 having a central opening 31 for the rigid shaft (6) of the drum motor, and said jacket 30 being formed as a circular disc of a relatively thin plate which is formed integrally with a peripheral flange 35, said flange 35 being formed to tightly engage an end edge 12 of the cylindrical drum 2 and to form a smooth transition to the external surface of the cylindrical drum 2.
Patent EP-0922029-B1 (EP)
Title: Ether muscarinic antagonists
Inventor: WANG YUGUANG
IPC: C07D211/96
Filed: 1997-08-13
Granted: 2005-06-08
Abstract: 1,4 Di-substituted piperidine muscarinic antagonists of formula (I) or an isomer, pharmaceutically acceptable salt, ester or solvate thereof, wherein X is a bond, -O-, -S-, -SO-, -SO2-, -CO-, -C(OR<7>)2-, -CH2-O-, -O-CH2-, -CH=CH-, -CH2-, -CH(C1-C6 alkyl)-, -C(C1-C6 alkyl)2-, -CONR<17>-, -NR<17>CO-, -O-C(O)NR<17>-, -NR<17>C(O)-O-, -SO2NR<17>- or -NR<17>SO2-; R is cycloalkyl, optionally substituted phenyl or optionally substituted pyridyl; R<2> is H, alkyl, optionally substituted cycloalkyl, cycloalkenyl, t-butoxycarbonyl or optionally substituted piperidinyl; and the remaining variables are as defined in the specification, are disclosed. Compounds of formula (I) are useful for treating cognitive disorders such as Alzheimer's disease. Also disclosed are pharmaceutical compositions, methods of preparation and combinations of compounds of formula (I) with ACh'ase inhibitors.
Patent EP-0952878-B1 (EP)
Inventor: HINTERHOLZER HANS
IPC: A63C19/06
Filed: 1997-09-03
Granted: 2003-07-02
Abstract: L'invention concerne une porte pour pistes de ski comprenant un panneau (1) fixé entre deux piquets (2, 3). Ce panneau possède, de chaque côté, un logement (5) tubulaire pour recevoir les piquets (2, 3) et deux fixations (6) supérieures pour attacher les piquets (2, 39. Pour créer des conditions de montage avantageuses, l'invention propose que le panneau (1) soit relié, dans la zone d'au moins un piquet (3), par un élastique en caoutchouc (12) à la fixation (6) qui est séparée du panneau (1).
Patent EP-0927258-B1 (EP)
Inventor: REZNIKOFF WILLIAM S
IPC: C12N15/55
Filed: 1997-09-09
Granted: 2003-04-23
Abstract: A system for in vitro transposition includes a donor DNA that includes a transposable element flanked by a pair of bacterial transposon Tn5 outside end repeat sequences, a target DNA into which the transposable element can transpose, and a modified Tn5 transposase having higher binding avidity to the outside end repeat sequences and being less likely to assume an inactive multimer form than wild type Tn5 transposase.
Patent EP-0951339-B1 (EP)
Inventor: FOURCOT FABRICE
IPC: B01D53/86
Filed: 1997-12-08
Granted: 2002-03-27
Abstract: The invention concerns a composition for treating fumes comprising: a base constituent containing bicarbonate and at least sodium carbonate and at least ammonia in the form of ammonium salts, and optionally a source of NH3; and catalytic quantities of one or several denitrification catalysts.
Patent EP-0883871-B1 (EP)
Inventor: BEYER ROLF
IPC: G08G1/09
Filed: 1997-12-10
Granted: 2002-09-04
Abstract: Disclosed is a traffic information method, whereby, on request and/or automatically, data are transmitted between a central control unit and a mobile subscriber unit. Also disclosed is a traffic information system, according to which at least one central control unit and at least a plurality of mobile subscriber units are provided.
Patent EP-0870426-B1 (EP)
Inventor: BOEHRINGER EBERHARD
IPC: A01G5/04
Filed: 1998-03-10
Granted: 2003-02-19
Abstract: The carrier material for plant cultivation, without soil, is a shaped body (2) with at least two layers (3,4) of nonwoven coir fibres, bonded together at the edges by a contour stiffening edge (5). Also claimed is a mfg. process using at least two semifinished coir nonwoven layers (3,4), to be laid over each other and pressed together. They are stamped into the required contour shape for the shaped body (2).