baber/WOPTO huggingface dataset:
Patent TW-202308665-A (TW)
Title: Double-stranded oligonucleotide, compositions and conjugates containing the double-stranded oligonucleotide, and preparation method and use thereof
Inventor: LIANG ZICAI
IPC: A61K31/7088
Filed: 2022-07-15
Abstract: Provided is a double-stranded oligonucleotide capable of regulating the expression level of a target gene, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand each comprises nucleotide sequence I or nucleotide sequence II consisting of 19 modified or unmodified nucleotides, the nucleotide sequence I and the nucleotide sequence II are at least partially reverse complementary to form a double-stranded region, and the nucleotide sequence II is at least partially reverse complementary to a nucleotide sequence in an mRNA expressed by the target gene; and according to the direction from the 5' end to the 3' end, at least one of the 3rd to 6th nucleotides of the nucleotide sequence II is a stabilized modified nucleotide, and none of the nucleotides other than the 3rd to 9th nucleotides in the nucleotide sequence II are stabilized modified nucleotides. The provided double-stranded oligonucleotide and pharmaceutical composition and conjugate comprising the double-stranded oligonucleotide may effectively treat and/or prevent diseases or disorders associated with target gene expression, and have reduced off-target effects.
Patent TW-202322976-A (TW)
Title: Dressing method and dressing device for grinding wheel
Inventor: ITO SHINJU
IPC: B24B49/18
Filed: 2022-07-29
Abstract: To appropriately perform setting of a dressing timing that has repeatability, effectively using experience and knowledge of a skilled expert regarding dressing timings for grinding wheels. The problem is addressed by: monitoring a grinding load during execution of grinding using a grinding wheel 24 under predetermined grinding conditions; saving the load at a point in time of a dressing set button 60, which is operated by an operator, generating a trigger signal as a dressing threshold value in a storage medium 62 along with the grinding conditions; reading the dressing threshold value corresponding to the grinding conditions from the storage medium 62 at the next time of execution of grinding; and executing dressing of the grinding wheel using this dressing threshold value.
Patent TW-202319147-A (TW)
Title: Silver powder and method for producing silver powder
Inventor: SUGAWARA SATOKO
IPC: B22F9/24
Filed: 2022-09-16
Abstract: Provided are: a silver powder suitable as a conductive filler for a conductive paste that can be fired at low temperature; and a method for producing the silver powder. The method for producing a silver powder comprises: an azole addition step in which an azole is added to an aqueous silver ammine complex solution to obtain a first liquid; a reducing agent addition step in which a reducing agent is added to the first liquid to obtain a second liquid; and a fatty acid addition step in which a fatty acid is added to the second liquid to obtain a third liquid, wherein the fatty acid is an unsaturated fatty acid containing two or more double bonds.
Patent TW-202321964-A (TW)
Title: Electronic device
Inventor: LEE KYUNG-SOO
IPC: G06F21/70
Filed: 2022-09-28
Abstract: Provided are an electronic device and an operating method thereof. The electronic device includes a nonvolatile memory; a power management integrated circuit configured to generate operating power based on supply power received from a power source, and generate first time information independent of the supply power; and an application processor configured to receive the operating power, generate second time information, obtain, based on the generation of the operating power being interrupted, the first time information, and output, to the nonvolatile memory, time data including the first time information and the second time information, a write command, and an address.
Patent TW-202335625-A (TW)
Title: Semiconductor manufacturing apparatus and processing method of semiconductor manufacturing apparatus
Inventor: FUJII HIROMICHI
IPC: A61B5/00
Filed: 2022-11-17
Abstract: A semiconductor manufacturing apparatus includes: an execution instruction receiving unit that receives an execution instruction for the semiconductor manufacturing apparatus to execute a predetermined process related to an operation control of the semiconductor manufacturing apparatus; an identification information receiving unit that receives an input of identification information of the semiconductor manufacturing apparatus; and an execution unit that executes the predetermined process according to the execution instruction of the predetermined process when identification information of the semiconductor manufacturing apparatus preset in the semiconductor manufacturing apparatus is the same as the identification information of the semiconductor manufacturing apparatus received by the identification information receiving unit.
Patent UA-38232-A (UA)
Title: Method for wound closure in external dacryocystorhinostomy
Filed: 2000-06-09
Abstract: The method for the wound closure in the external dacryocystorhinostomy provides for the application of Z-shaped suture onto the orbicular muscle of eye. The invention relates to the ophthalmology and may be used for the surgical treatment of the chronic dacryocystitis.
Patent UA-39052-A (UA)
Title: Method for pulse laser thermodestruction of intracerebral tumors of brain hemispheres
Filed: 2001-01-26
Abstract: The invention relates to the medicine, namely to the neurosurgery and may be used for the surgical treatment of the intracerebral tumors of brain hemispheres. The method for pulse laser thermodestruction of the intracerebral tumors of brain hemispheres provides for the use of high-energy laser radiation of neodymium laser based of alumoyttrium garnet. After the surgical removal of the major part of the tumor and the provision for the hemostasis towards the remnants of the tumor infiltration of the walls in postoperative bed, the pulse laser thermodestruction is performed.
Patent UA-45581-A (UA)
Inventor: CHUHUI VOLODYMYR LEONIDOVYCH
Filed: 2001-02-01
Abstract: A method for converting inertia forces into torque, in which rotation of a crank shaft and of a lever pin with respect to the crank shaft base journals, in common with the swinging movement of the connecting rod, are performed.
Patent UA-41155-A (UA)
Title: Supporting lattice of packed mass-exchange column
Inventor: MIKULIONOK IHOR OLEHOVYCH
Filed: 2001-03-06
Abstract: The invention relates to the manufacturing equipment for conducting heat-mass-transfer and chemical processes (for example, rectification, absorption) and it can be used in chemical, refine oiling, food and other branches of industry. A supporting lattice of packed mass-exchange column contains vertically located parallel plates fastened between them with formation of slots between them. A perforated tray is installed from the side of the lower edges of plates.
Patent UA-44643-A (UA)
Inventor: SHEVCHUK SERHII VIKTOROVYCH
Filed: 2001-07-06
Abstract: The orthopedic angular gage contains the housing, the arch scale, the spherical indicator located within the closed housing channel, and the fixing device made of adhesive material.
Patent UA-47265-A (UA)
Inventor: MOISEENKO ANATOLII IVANOVYCH
Filed: 2001-09-28
Abstract: The method for estimating the extent of the colon resection in case of the chronic ileus of non-tumor genesis provides for the X-ray control of contrast substance passage through the colon. The irigograms at the stages of the tight filling and colon evacuation are recorded. Then the irigocharts are plotted and the area of the colonic sections at these two stages are calculated. The coefficient of the functional state of the colon is calculated according to the formula: К=Stight filling/Sevacuation, where Stight filling – area of colon section at the stage of the tight filling, Sevacuation – area of colon section at the stage of colon evacuation. The extent of the colon resection is estimated on the basis of the coefficient value being calculated as stated above.
Patent RS-20050316-A (RS)
Title: Universal devices and processes for foodstuff shaping and decorating
Inventor: NIKASINOVIC SLOBODAN
IPC: A23G3/00
Filed: 2005-04-20
Abstract: Universal devices and processes for foodstuff shaping and decorating consists from a continual process and devices for continual process, while foodstuff gelling masses are poured into an endless tubular mould (3), which passes through a cooler (4) where the mass solidifies and at the end goes out of the endless tubular mould (3) and is radically cut, when parts of the product overflow, and at the same time make printed decorative plates, synchronously set onto the coated pieces of the product, and thereupon sprinkled by foodstuff sprinklers, cooled, and released from the surplus and packed. Universal device and shaping procedures and decoration of foodstuff products, consist of discontinual procedure, where gelling foodstuff mass is poured into the tubular moulds, with plastic baglike inserted piece where it remains up to solidity and thereupon it is taken out and further treated as to the same, above mentioned, process. Universal device and processes for shaping and decoration of foodstuff products with a core and lateral envelope consists of a discontinual process, where the first gelling mass is poured into a tubular mould, with sticklike inserted piece, where it rests up to the solidity, then the sticklike inserted piece is taken out and the other mass is poured into the empty space, when solidified the mass is taken out and radially cut into pieces.
Patent DO-P2003000634-A (DO)
Title: Inhibidores de metaloproteinasa de triaril-oxiaril-espiro-pirimidina-2,4,6-triona
Inventor: FREEMAN-COOK KEVIN DANIEL
Filed: 2003-04-24
Abstract: La presente invención se refiere a inhibidores de metaloproteinasa de triaril-oxiaril-espiro-pirimidina-2, 4, 6-triona de formula en la que el anillo x es un anillo heterocíclido de 5-7 miembros, y donde a, y, b, g y w son tal y como se han definido en la memoria descriptiva; y a composiciones farmacéuticas y procedimientos de tratamiento de la inflamación, cánceres y otros trastornos.
Patent DO-P2007000049-A (DO)
Title: Concentrados acuosos para suspencion
Inventor: FRISCH GERHARD
Filed: 2007-03-13
Abstract: El invento se refiere a concentrados acuosos para suspensión, que contienen (1) una o varias sustancias activas seleccionadas entre el conjunto formado por 2,4-diamino-s-triazinas eficaces como herbicidas, que están sustituidas en N junto a un grupo amino con un grupo (hetero)aril(hetero)alquilo, (2) una o varias sustancias activas seleccionadas entre el conjunto formado por derivados que contienen grupos fosfatos, eficaces como herbicidas, de los aminoácidos glicina/alanina, (3) uno o varios agentes tensioactivos sobre la base de fenol-éteres sustituidos, de tipo no salino, (4) uno o varios agentes espesantes, de manera preferida agentes espesantes sobre la base de silicatos de aluminio, y (5) eventualmente otros agentes coadyuvantes de formulación, así como (6) eventualmente otros agentes tensioactivos diferentes del componente (3). Junto a una alta estabilidad de las sustancias activas en las formulaciones se consigue, a igualdad de cantidad consumida, un mejor efecto biológico.
Patent DO-P2012000122-A (DO)
Title: Inmunoglobulinas con dominio variable dual y usos de las mismas
Inventor: YING HUA
IPC: C12P21/08
Filed: 2012-04-26
Abstract: Proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, eI diagnóstico y/o el tratamiento de enfermedades.
Patent EC-SP11011042-A (EC)
Title: Compuestos de arilo con sustituyentes heterocíclicos como inhibidores hif
Inventor: THIERAUCH KARL-HEINZ
IPC: C07D413/04
Filed: 2011-05-11
Abstract: La presente solicitud se refiere a compuestos de arilo novedosos con sustituyentes heterocíclicos, a procedimientos para su preparación, a su uso para el tratamiento y/o la prevención de enfermedades y a su uso para la preparación de medicamentos para el tratamiento y/o la prevención de enfermedades, en particular para el tratamiento y/o la prevención de enfermedades hiperproliferativas y antiangiogénicas y para aquellas enfermedades que surgen de la adaptación metabólica a estados hipóxicos. Tales tratamientos se pueden llevar a cabo como monoterapia o también en combinación con otros medicamentos o medidas terapéuticas adicionales
Patent GB-189702928-A (GB)
Title: Improvements in Bicycle Saddles.
Inventor: DEITZLER MARTIN LUTHER
Filed: 1897-02-03
Granted: 1897-09-18
Abstract: 2928. Deitzler, M. L. Feb. 3. Saddles for bicycles. Fig. 2 shows the underside of the saddle Two pads B, separated by a .space, are adjustably secured by clamps B' to the spring framework shown. The saddle is fixed to the bicycle by the tongue a.
Patent GB-189706215-A (GB)
Title: Improvements in Velocipedes.
Inventor: FOX CHARLES EDGAR
Filed: 1897-03-09
Granted: 1897-08-07
Abstract: 6215. Fox, C. E. March 9. Saddle supports; frames; axles, cranked, supporting. -The saddle piliar 6 is continued downwards through the tube 2 of the frame and screwed into a sliding block 9, carrying the crank bracket 8. The weight on the saddle and on the crank axle is carried by a spring, as shown. Grooves 10, Fig. 4, in the socket 9 engage with studs 12 fixed to the tube 2 so as to prevent the crank bracket from turning. A screw 7 engaging a groove in the saddle pillar serves the same purpose, and may also be used to fix the saddle pillar to the frame.
Patent GB-189708456-A (GB)
Title: Improvements in Compressors for Refrigerating Apparatus.
Inventor: MUIR JOHN
Filed: 1897-04-02
Granted: 1897-06-19
Abstract: 8456. Muir, J., Morse, E. A., and Pierson, F. O. April 2. Ice-making.-Relates to air and gas compressors. A casing A encloses the cylinders F and driving- mechanism &c. The crank shaft B runs in bearings carried by caps a<6>, a<7> on the lower part of the casing, which forms an oil bath. The cylinders F and the upper valve seatings 0 are secured by the top cover D. Incoming gas at a<13> circulates between the casing and the cylinders so as to cool them. The connecting-rods are each made in two parts, adjustable in length by screw couplings L, and are connected to the pistons H by transverse pirs I. One half M' of each bearing is fixed to the connecting-rod and the other M is carried by the springs m<3>, gaide-pins m<1>, and abutments m<2> on the rods so as to be self-adjusting. The valves in the pistons H and seatings 0 are carried by springs and guide-pins. A handhole and cover are provided.
Patent GB-189709063-A (GB)
Title: Improvements in Ball Casters.
Inventor: PARRY HENRY
Filed: 1897-04-09
Granted: 1898-03-26
Abstract: 9063. Parry, H., and Bond, C. April 9. Castors. -The ball bears in a cup, and is retained by a ring c fixed in the flange b by three screws d having hollow ends, against which bear three small balls. A screw with hollow head e forms the bearing for another small ball, which takes the weight.
Patent GB-189710476-A (GB)
Title: Improvements in Roving Machines and the like.
Inventor: PEIRCE WILLIAM COPELAND
Filed: 1897-04-27
Granted: 1897-06-19
Abstract: 10,476. Peirce, W. C. April 27. Roving frames &c.-The lifting-rail is divided into two or any even number of parts or sections, and one half of these sections are caused to balance the remaining sections, so that the varying load due to the gradual filling of the bobbins does not affect the balance of the machine, and the usual counterweights are dispensed with. The rails I are raised and lowered by racks 9<a> and 10<b>, which are engaged by pinions on a longitudinal shaft 28 rotated in opposite directions alternately from the usual reversing-shaft connected with the cop-building mechanism. The racks of the different sections engage with their pinions on opposite sides of the shaft 28, so that one section rises as the other falls and the whole is properly balanced. The whole of the driving-mechanism is situated in a headstock at one end of the machine. For driving the bobbins of sections situated at a distance, the usual bobbin-driving sleeve is connected by means of a back shaft with a wheel similar to the original bobbin-wheel and situated on a short shaft in the section to be driven. This new bobbin-wheel will engage with the wheels of a "swing" 35, such as is usually employed. The gearing for driving the spindles and bobbins may be enclosed in casings 40 fitted with doors.
Patent GB-189710615-A (GB)
Title: Improvements in Metallic or Wire Brushes.
Inventor: BEISSEL KARL WINAND
Filed: 1897-04-28
Granted: 1897-07-03
Abstract: 10,615. Beissel, K. W. April 28 Bristles; stocks.- The bristles d are formed of thin narrow strips of metal more or less twisted. Fig. 7 shows one form. The bristles are fixed in stocks formed of bent sheet metal, the plates b, g of which are some distance apart. The bristles at the ends of the brush may be protected by metal caps f. The handle e may be secured by bolts and nuts c.
Patent GB-189712891-A (GB)
Title: Improvements in or connected with Clips or Fingers for Music Holders and the like.
Inventor: JONES THEODORE BROOKE
Filed: 1897-05-25
Granted: 1897-07-24
Abstract: 12,891. Jones, T. B. May 25. Leaf-holders.-A metal case A with flange B is screwed into the book ledge E. On the finger M is a flange K and headed stem G, F. A spring between the head G and flange B presses the flanges K and B together, the friction being sufficient to keep the finger in place. The casing A may screw into a fitting N, a friction washer P being provided. The edge of the flange B may be milled. The casing A may screw into a fitting R secured under the ledge E, Fig. 4, and a lock nut S may be provided to secure the friction plate K to its spindle. The barrel A may be unthreaded and slightly tapered.
Patent GB-189715813-A (GB)
Title: Improvements in and connected with the Manufacture or Production of Ozone and in Apparatus therefor.
Inventor: ANDREOLI EMILE
Filed: 1897-07-02
Granted: 1898-11-27
Abstract: 15,813. Andreoli, E. July 2. Ozone.-Ozone is obtained for commercial purposes by passing air through open or closed ozonizers in which it is subjected to a silent electric discharge, the glow of which is reduced to a minimum to avoid the generation of excessive heat and the formation of nitrous compounds. Fig. 3 shows a section of an open ozonizer with point-bearing electrodes a, each consisting of a series of longitudinal vertical serrated wires b separated by washers c and united by bolts d. These electrodes alternate with flat electrodes e, which may be formed of a board having thin metal sheets upon its two surfaces, or both electrodes may be either point-bearing or flat. Between the electrodes are single or double sheets of dielectric material h, supported in grooves in the frame, and separated from the electrodes by glass distancepieces h. The parts are held together by a frame q secured together by wooden clamping-screws r. In a closed ozonizer also described, there is at the base a small air or distributing chamber, above that an intermediate ozonizing-chamber, and above that a collecting-chamber communicating with the outlet. The compartments are separated by perforated partitions. A number of the open ozonizers may be arranged in one chamber s, as shown in Fig. 7, being placed over openings t in the floor u above an air chamber v. The ozonized air passes through a tube for use as required. The air is forced or drawn through the chamber.
Patent GB-189723797-A (GB)
Title: Improvements in Machines for Stuffing Mattresses.
Inventor: GRIFFITH AMENZO
Filed: 1897-10-15
Granted: 1898-05-14
Abstract: 23,797. Griffith, A. Oct. 15. Upholstery stuffing - apparatus. - The cover or ticking of a mattress is placed on a spout d, and when the sliding gate b is withdrawn, the stuffing, which has been compressed into the chamber E by the closing of the two hinged parts B, C of the lid, is forced into the cover by the end-piece D, which is traversed by chains g connected to it and passing over sprocketwheels h, driven by gearing and by pulleys and belts j, j<2>, one of which is crossed. There are two loose pulleys and one fast pulley, so that by shifting the belts the end-piece D can be traversed backwards and forwards. The lid B, hinged at 16, is opened and closed by the sliding bars G, to which it is connected by the links H, which also act as a toggle and compress the stuffing when the lids are closed. The lid C is opened by the chain J, passing over the pulley n, and connected to the bars G and to the cleat 40. The bars G are traversed by chains s driven from a shaft v, which is rotated in either direction by one of the belts e<3>, e<4>, and by a clutch operated by the handle x<2>.
Patent GB-189801012-A (GB)
Title: An Improved Form of Socket for the Stem of a Cycle Handle-bar.
Inventor: RANSOM CHARLES
Filed: 1898-01-13
Granted: 1898-07-30
Abstract: 1012. Ransom, C. Jan. 13. Handle - bars.- The stems bare formed of a square or other prismatic form adapted to fit into suitablyshaped holes in the socket c, which is secured in the steering-tube g. The stem b may be gripped by means of the split collar d in the usual manner.
Patent GB-189813093-A (GB)
Title: Improvements in Sounding Boards for Pianos and like Instruments.
Inventor: READING HERBERT SAMUEL
Filed: 1898-06-11
Granted: 1899-06-10
Abstract: 13,093. Reading, H. S., [trading as Reading, W.], Reading, P. A., and Reading, O. E. June 11. Pianofortes ; sound-magnifying appliances. - Consists in using aluminium or its alloys for soundboards. The aluminium is rolled to a thickness of about one-eighth of an inch, and is secured in rabbets b in the frame in the manner shown in Fig. 4, excepting a small part between the bridge and the top bar of the framing, where it is left free. The rabbet at the bass side of the frame is shaped so as to give a camber to the soundboard, but elsewhere it is flat. The rabbets may be faced with a strip of iron to which the soundboard a is screwed at frequent intervals, a strip f of felt being interposed. The bridge and strengthening-bars, if any, are secured by screws, felt washers being used to prevent jarring. The Provisional Specification states that metals other than aluminium or its alloys may be used.
Patent GB-189814578-A (GB)
Title: A Protective Cover for Railway Detonator Signals.
Inventor: HESS FILIPP
Filed: 1898-07-01
Granted: 1898-08-06
Abstract: 14,578. Hess, F., and Zigall, J. July 1. Fog and audible signals.-Consists of a protective cover for detonator signals, to prevent the scattering of their fragments when they are exploded by a train. The cover consists of a top piece a and a bottom piece b, the top piece having downwardly-turned edges which secure it to the bottom piece. The top piece may be strengthened by a plate f, and may be provided with a pressure pm d for exploding the detonator. Slots or perforations may also be formed in it to relieve the pressure of the explosion. The bottom piece is formed with corrugations p, and the spaces between these and the top piece are filled with a suitable packing q, to prevent the scattering of fragments lengthwise of the rail. Fragments scattered sideways are deflected downwards by the edges of the top piece, and so rendered harmless. The detonator e is inserted through an aperture in the bottom piece, and is secured by giving it a quarter turn. The cover may be partly or entirely encased or lined with woven fabric, leather, gauze, &c.
Patent GB-189815986-A (GB)
Title: Improvements in or relating to the Manufacture of Sheet-metal Hollow-ware.
Inventor: REES WILLIAM
Filed: 1898-07-22
Granted: 1899-05-20
Abstract: 15,986. Rees, W. July 22. Making boxes and cases.-Relates to the construction of vessels or boxes of rectangular cross-section. The bottom and two sides are formed from a blank cut out and curled over along the edges as shown in Figs. 1 and 2. The two other sides are formed as shown in Figs. 3 and 4, and the parts are assembled as shown in Fig. 6. The edges are then as shown in Fig. 7, and the seams are completed by bending over the parts 24 and 27 as shown in Fig. 8. The top edges 29 are beaded over by means of a die 30, as shown in section in Fig. 12, and are then wired as shown in Fig. 14.