baber/WOPTO huggingface dataset:
Patent DK-0590789-T3 (DK)
Inventor: ORNSTEIN PAUL LESLIE
IPC: A61P25/28
Filed: 1993-08-25
Granted: 2004-03-22
Abstract: This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof. The novel pharmaceutical compounds have the formula <CHEM>  wherein: R<1> is hydrogen, C1-C10 alkyl, arylalkyl, alkoxycarbonyl or acyl;  R<2> is hydrogen, C1-C6 alkyl, substituted alkyl, cycloalkyl, or arylalkyl;     R<3> is CO2H, SO3H, CONHSO2R<8>, or a group of formula <CHEM>   <CHEM>   <CHEM>     W is (CH2)n, S, SO, SO2;     Y is CHR<7>, NR<4>, O, S, SO, or SO2;     Z is NR<6>, CHR<7>, or CH; or W and Y together are HC=CH or C IDENTICAL C, or Y and Z together are HC=CH or C IDENTICAL C;     R<4> is hydrogen, C1-C4 alkyl, phenyl, or acyl; R<5> is hydrogen, C1-C4 alkyl, CF3, phenyl, hydroxy, amino, bromo, iodo, or chloro;     R<6> is acyl; R<7> is independently hydrogen, C1-C4 alkyl, phenyl, or substituted phenyl;     R<8> is C1-C4 alkyl or tetrazole-5-yl; and     n is 0, 1, or 2; provided that when Y is NR<4>, O, S, SO, or SO2, W is (CH2)n and Z is CHR<7> or CH; further provided that when W is S, SO, or SO2, Y is CHR<7>, Z is CHR<7> or CH, or Y and Z together are HC=CH or C IDENTICAL C;     further provided that when W and Z are CH2, Y is not S; further provided that when W and Y together are HC=CH or C IDENTICAL C, Z is CHR<7>; or a pharmaceutically acceptable salt thereof. 1,
Patent DK-0577555-T3 (DK)
Inventor: BOEGER MANFRED
IPC: A01N43/82
Filed: 1993-06-22
Granted: 1998-07-27
Abstract: Compounds of the formula <IMAGE>  in which     A denotes oxygen, sulphur or -NR1-;   B denotes C2-C6-alkylene; D-E denotes -O-E, -S-E, -O-CH2-E, -O-C(=O)-E, -O-C(=O)-O-E, -O-C(=O)-N(H)-E or -O-C(=S)-N(H)-E; E denotes phenyl; phenyl substituted by 1 to 3 substituents; a five-membered aromatic heterocycle having one to three hetero atoms; a five-membered aromatic heterocycle having one to three hetero atoms and substituted by one or two substituents; a six-membered aromatic heterocycle having one to three nitrogen atoms; or a six-membered aromatic heterocycle having one to three nitrogen atoms and substituted by one or two substituents;   L denotes halogen or methyl;   X denotes fluorine;   Y denotes chlorine or fluorine;   Z denotes hydrogen, fluorine or methyl;   m denotes the number zero, one, two, three, four or five;   n denotes the number zero, one or two and   R1 denotes hydrogen, C1-C4-alkyl, phenylthio or tolylthio, in free form or in salt form, can be used as pesticides and can be prepared in a manner known per se.
Patent DK-0642581-T3 (DK)
Inventor: TITBALL RICHARD WILLIAM CBDE P
IPC: A61P31/04
Filed: 1993-05-20
Granted: 2003-02-17
Abstract: The present invention provides novel peptides and vaccines containing them capable or inducing production of antibodies directed against Clostridium perfringens alph-toxin (CPa) in animals to which the) arc administered and thereby providing pro-phylazis against infection by Clostridium pefringens and/or the alpha-toxin itself. Particularly the present invention provides such a vaccine that is relatively safe and simple to produce. e.g. by genetic engineering means. Preferred peptides comprise theo amino acid sequence of Clostridium perfringens alpha-toxin from amino acid 247 to 370 but lack the epitopes necessary for phos-pholipase C and/or sphingomyelin hydrolysing activity round between amino acids 1 to 240 of that sequence. Further provided are antisera and antibodies raised to the peptides and vaccines of the present invention, and particularly monoclonal antibodies and hybridoma cell lines for their production.
Patent DK-0625670-T3 (DK)
Inventor: HARO JUERGEN
IPC: F16L55/12
Filed: 1994-02-22
Granted: 1996-11-18
Abstract: The seal fits in a pipe (1), having an inflatable cushion (5) in a holder (2). The cushion is of coated inelastic textile material, and in the uninflated state forms an annular hose with a folded wall (12), its OD matching the ID of the pipe. On inflation, it expands inwards from the pipe wall (8) to the centre. When uninflated, the hose outside wall (11) can bear against the pipe wall, while its inside wall (12) is folded. It can be secured by elastic components (15,16) to the holder, and which pull the inner wall into the folded position when uninflated.
Patent DK-0620225-T3 (DK)
Inventor: ANGEHRN PETER
IPC: A61P31/04
Filed: 1994-03-30
Granted: 2003-03-17
Abstract: Cephalosporin derivatives of the general formula <CHEM>  wherein   R<1>   is an acyl group derived from a carboxylic acid; R<2>   is hydrogen, hydroxy, lower alkyl-Qm, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl-Qm, aryl-Qm, aryloxy, aralkoxy or a heterocyclic ring, the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl, aryl, aryloxy, aralkoxy and the heterocyclic ring being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, -CONR<4>R<5>, -N(R<5>)COOR<9>, R<5>CO-, R<5>OCO- or R<5>COO- where R<4> is hydrogen, lower alkyl, or cycloalkyl; R<5> is hydrogen or lower alkyl; R<9> is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group; Q   is -CO- or -SO2-; m   is 0 or 1; n   is 0, 1 or 2; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts. The products are antibacterially active.
Patent DK-0672141-T3 (DK)
Inventor: SPRIGGS MELANIE K
IPC: C12P21/02
Filed: 1993-10-20
Granted: 2003-06-10
Abstract: There is disclosed a method of preparing a soluble mammalian protein by culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a leucine zipper domain and a heterologous mammalian protein.
Patent DK-0639063-T3 (DK)
Inventor: FRADEN JACOB
IPC: G02B6/02
Filed: 1994-03-04
Granted: 1999-11-15
Abstract: An optical infrared thermometer has a sole core, refractive rod waveguide in an optical path between the infrared reception portion of the thermometer and the infrared sensor of the thermometer.
Patent DK-0717928-T3 (DK)
Inventor: ALVAREZ BERENGUER ANTONIO
IPC: A01K1/015
Filed: 1995-11-17
Granted: 2000-09-18
Abstract: The litter is comprised of: (a) an absorbent porous granular solid comprised of sepiolite with a granulometric particle size distribution comprised between 6 and 60 ASTM mesh and an apparent density between 400 and 800 g/l; (b) a polymer or mixture of absorbent polymers, chosen from among cellulose and starch derivatives, gums coming from algae, plants or microorganisms, polysaccharides, seed oils and animal glue, in an amount of 0.1 to 10% by weight with regard to (a). The litter is used to collect excrements and solids of pets, especially, cats.
Patent DK-0702015-T3 (DK)
Inventor: HOULIHAN WILLIAM JOSEPH
IPC: C07D513/04
Filed: 1995-09-11
Granted: 1998-01-12
Abstract: The invention concerns oxazole and thiazole compounds of formula <CHEM> where the substituents have various significances, in free form or salt form as appropriate. They can be prepared e.g. by coupling or hydrolysis. The compounds can be used as pharmaceuticals, especially as hypoglycemic agents in the treatment of diabetes.
Patent DK-0781341-T3 (DK)
Inventor: CAMERON BEATRICE
IPC: C12P21/02
Filed: 1995-09-14
Granted: 2009-01-05
Abstract: PCT No. PCT/FR95/01178 Sec. 371 Date Mar. 12, 1997 Sec. 102(e) Date Mar. 12, 1997 PCT Filed Sep. 14, 1995 PCT Pub. No. WO96/08572 PCT Pub. Date Mar. 21, 1996Expression plasmids comprising a nucleic acid sequence of interest controlled by a T7 bacteriophage promoter and a stabilizing region comprising all or part of the par region of the RP4 plasmid or a derivative thereof. The invention also concerns the use of said plasmids in the production of recombinant products.
Patent DK-0742630-T3 (DK)
Inventor: PIEDNOEL FRANCOIS
IPC: H02H3/00
Filed: 1996-05-07
Granted: 2002-02-18
Abstract: The control procedure commences with setting an initial safety cut-out level for the torque of the electric motor driving the closure device. The level is set from a database of effort needed by the motor to operate the closure device. As the closure is displaced the effort is measured and compared to the safety threshold. If the effort is too high the motor stops. A new security threshold is automatically set and the motor restarted after a set delay. An absolute maximum threshold is provided, and any new levels cannot be higher than this maximum. The system thus learns new values of settings for effort required at different stages of the movement, adapting to a particular operating environment and adapting to changes.
Patent DK-0958421-T3 (DK)
Inventor: MARCHETTI LUIGI
IPC: D05B73/12
Filed: 1997-04-09
Granted: 2002-12-02
Abstract: The equipment comprises in combination: a twin needle (15, 17) fed with two needle threads (F1, F2); an upper looper (30) fed with a looper thread (F3), and a lower spreader (31); a throat plate (36) with two slots (38, 40) for the needles (15, 17) and the stitch finger (42) on the line of the cut (T) of increased width (D); and a thread-pulling arm (25) for pulling off an increased amount of the thread (F3) for the looper at each angular stroke.
Patent DK-0918545-T3 (DK)
Inventor: BAGSHAWE KENNETH DAWSON
IPC: A61K47/48
Filed: 1997-11-28
Granted: 2000-11-27
Abstract: A three component therapeutic system comprising (i) a first compound, (ii) a catalytic macromolecule which does not specifically bind to a tumour antigen but which is capable, following administration to the vascular compartment of a mammal, of being taken up by a tumour in the mammal and is capable of converting the first compound into a second compound, and (iii) an inhibitor which, following administration to the said vascular compartment, reduces the level of the said catalytic conversion activity in the vascular compartment.
Patent DK-0870788-T3 (DK)
Inventor: GERLITZ MARIN
IPC: C09D175/04
Filed: 1998-04-07
Granted: 2003-10-27
Abstract: Radiation hardenable, water dilutable urethane resins (I) are prepared by mixing (A) 1.0 mole of a cycloaliphatic and/or aromatic diisocyanate with (B1) 0.2-0.6 moles (w.r.t. reactive hydroxyl groups ) of a (meth)acryloyl group containing dihydroxy compound and (B2) 0.4-0.8 moles (w.r.t. reactive hydroxyl groups) of a (meth)acryloyl group containing, initially three or four valent polyol with a residual average hydroxy functionality of 1.0-1.4, such that the sum of reactive hydroxy groups in (B1) and (B2) is equal to 1.0 mole. Up to 50 mol.% of NCO groups of the product of (A), (B1) and (B2) are converted to urethane groups and the resulting intermediate product is mixed with (C) 0.3-0.5 mol. 2,2-bis-(hydroxymethyl)-propionic acid until complete reaction of the hydroxy groups of (C) occurs and optionally with 0.2-0.5 moles of (B2) until complete reaction of the residual free isocyanate groups. The ratio of isocyanate to hydroxy groups in (A) and (C) is 0.9:1 - 1:1 and the carboxyl group content of the product corresponds to an acid number of 20-40 mg KOH/g, that is neutralised to at least 40% by addition of an alkali hydroxide or tert. amine. The double bond equivalent is a maximum of 3.5 mmole/g solid urethane resin.
Patent DK-0904704-T3 (DK)
Inventor: KUENEN HENDRIKUS ANTONIUS JACO
IPC: A23L7/157
Filed: 1998-09-01
Granted: 2003-03-24
Abstract: A device for coating food products with granular material, for example breadcrumb material, comprises a rotating conveyor belt which is permeable to the granular material and on which the food products can be held, guide plates which extend beneath at least a section of the top part and the bottom part of the conveyor belt, a feed, which opens out above the top part of the conveyor belt, for the granular material, diverter means for guiding the granular material from the top part to the bottom part of the conveyor belt and back, as well as conveyor means for conveying granular material from the top part of the conveyor belt to the feed. A divider plate to which granular material is fed from the top part of the conveyor belt is situated between the top part and the bottom part of the conveyor belt, via which divider plate the selected granular material is fed to the bottom part of the conveyor belt.
Patent DK-0902094-T3 (DK)
Inventor: PICHARD CLAUDE
IPC: C22C38/18
Filed: 1998-09-09
Granted: 2003-08-25
Abstract: A mechanical component is produced by heat treating a low alloy steel, before surface induction hardening, to form a structure of ferrite and ≥ 80% lamellar pearlite at least in the region to be surface hardened, the heat treatment being carried out before, during or after operations of shaping an ingot of the steel to a rough product. A process for producing a mechanical component, which is surface induction hardened by two austenitizing operations followed by quenching to obtain a ferrite- and undissolved carbide-free martensitic structure of hardness greater than 800 HV and of ASTM grain size index ≥ 7, involves (a) producing an ingot of steel of composition (by wt.) 0.43-0.62% C, 0.5-1.6% Mn, 0-0.8% Si, 0-0.5% Ni, 0-1.5% Cr, 0-0.35% Mo, 0-0.15% V, 0.005-0.05% Al, 0.004-0.022% N, up to 0.1% S, up to 0.1% Pb, up to 0.012% Te, up to 0.04% Se, up to 0.13% Bi, up to 0.005% Ca, balance Fe and impurities, the sum of Mn, Ni, Cr, Mo, V and Si being 0.95-3%; and (b) heat treating as described above. An Independent claim is also included for a mechanical component which consists of the above steel and which has an induction quench hardened portion with the martensitic structure described above, the rest of the component having a structure of ferrite and ≥ 80% lamellar pearlite.
Patent DK-0979093-T3 (DK)
Inventor: MARKHAM ALEXANDER FRED
IPC: A61K35/76
Filed: 1998-02-24
Granted: 2002-04-02
Abstract: The invention relates to the use of anti-herpetic sensitive viruses in the treatment of diseases and particularly cancer. More specifically, the invention concerns the genetic manipulation of viruses that are susceptible to anti-herpetic agents so as to enhance their sensitivity to said agents and/or reduce their pathogenicity.
Patent DK-1092383-T3 (DK)
Inventor: CANALE GIUSEPPE
IPC: F16L27/12
Filed: 1999-10-11
Granted: 2008-08-25
Abstract: A telescopic extension (1; 51) for an electric household appliance comprises an inner tube (2), an outer tube (3), a sleeve (4), at least one first constraining element (5; 6), a thrusting slider (7), resilient elements (24) and an actuating element (8); in the extension (1; 51) the sleeve (4) is arranged between the inner tube (2) and the outer tube (3) having a cross-section of substantially constant diameter, the sleeve (4) is provided with a longitudinal cavity (15) and a recess (19) formed on the bottom (18) of the cavity (15), the thrusting slider (7) is housed in the longitudinal cavity (15) and retained radially by the outer tube (3), the thrusting slider (7) is provided with at least one first slot (26) and the resilient means (24) are housed in the first slot (26) of the thrusting slider (7) and are engaged with a recess (19) of the sleeve (4). <IMAGE>
Patent DK-1056873-T3 (DK)
Inventor: SLOMA ALAN
IPC: C12N15/09
Filed: 1999-02-26
Granted: 2010-07-26
Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a Bacillus host cell in a medium conducive for the production of the polypeptide, wherein the Bacillus cell comprises a nucleic acid construct comprising (i) a tandem promoter in which each promoter sequence of the tandem promoter is operably linked to a single copy of a nucleic acid sequence encoding the polypeptide and alternatively also (ii) an mRNA processing/stabilizing sequence located downstream of the tandem promoter and upstream of the nucleic acid sequence encoding the polypeptide; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to methods for producing a polypeptide, comprising: (a) cultivating a Bacillus host cell in a medium conducive for the production of the polypeptide, wherein the Bacillus cell comprises a nucleic acid construct comprising (i) a "consensus" promoter having the sequence TTGACA for the "-35" region and TATAAT for the "-10" region operably linked to a single copy of a nucleic acid sequence encoding the polypeptide and (ii) an mRNA processing/stabilizing sequence located downstream of the "consensus" promoter and upstream of the nucleic acid sequence encoding the polypeptide; and (b) isolating the polypeptide from the cultivation medium.
Patent DK-1148789-T3 (DK)
Inventor: CHMIEL OLIVER
IPC: A23C11/08
Filed: 1999-12-30
Granted: 2004-11-29
Abstract: The invention relates to an aromatized, soluble creamer powder. The creamer particles are formed of a matrix of one or more proteins, fats, and carbohydrates, and an aroma system. The aroma system is formed of aqueous coffee aroma components and soluble coffee solids in preferred ratios to help stabilize the unstable aqueous coffee aroma components. The creamer powder may be used, e.g., in soluble coffee beverage powders.
Patent ES-2237362-T3 (ES)
Title: Metodo autoadaptativo de control de una unidad de inyeccion para motor de combustion interna.
Inventor: POGGIO LUCA
IPC: F02D41/14
Filed: 2000-04-27
Granted: 2005-08-01
Abstract: Un método auto-adaptable para controlar la concentración de soluto de un motor de combustión interna 2 equipado con un sistema para reducir las emisiones contaminantes 4 y un primer y un segundo sensor que detectan la composición estequiométrica de la solución (5, 6) y que están dispuestos respectivamente a la entrada y a la salida de este sistema reductor de emisiones contaminantes 4, y a su vez, respectivamente adaptados para generar una señal que indica la composición de la solución del flujo de entrada (V1) y de salida (V2). Este método se divide en las siguientes fases: a1.Calcular un coeficiente de corrección KO2 en función de la información transmitida por la señal de composición del soluto del flujo de entrada (V1), la señal de composición de la solución del flujo de salida (V2), y un valor meta (Vº) cuya función es indicar cual es el valor meta de la concentración de los gases de escape.
Patent ES-2327891-T3 (ES)
Title: Soporte de plantilla, dispositivo medidor de forma deseada de lente que comprende este soporte, y un aparato de procesado de lentes de gafas que tiene este dispositivo.
Inventor: MATSUYAMA YOSHINORI
IPC: B24B17/02
Filed: 2000-04-27
Granted: 2009-11-05
Abstract: Un soporte de plantilla (310) que se usa en la medición de una forma deseada de una lente de gafas y que soporta encima al menos una de una plantilla (350) y una lente simulada, incluyendo el soporte: una porción de unión de plantilla incluyendo: una porción de colocación de plantilla, en que están dispuestos pasadores de colocación (321a, 321b) a introducir en pequeños agujeros (351) de la plantilla, para colocar la plantilla a lo largo de un plano de medición; y un brazo de sujeción (311) que sujeta la porción de unión de plantilla; caracterizado porque la porción de unión de plantilla incluye: un eje de soporte (323) a introducir en un agujero central (351) de la plantilla, pudiendo moverse los ejes de soporte (323) con relación a la porción de colocación de plantilla para deslizar la plantilla en y a lo largo del plano de medición; medios de empuje (313) para empujar el eje de soporte (323) de manera que se mueva en una dirección de empuje; y medios de movimiento (312, 314) para mover el eje de soporte (323) en una dirección opuesta a la dirección de empuje contra una fuerza de empuje de los medios de empuje (313) cuando la plantilla se ha de montar o desmontar.
Patent ES-2221828-T3 (ES)
Inventor: MITTERSINKER GREGOR
IPC: B43K3/00
Filed: 2000-03-07
Granted: 2005-01-16
Abstract: The hand instrument (10) has a variable grip arrangement, with the body having an active end (14), and an opposite end (16). A resilient material forms a grip (18) around the body near the active end. Radial expansion beams (20) are under the grip for bending radially outwardly for expanding the grip into an expanded ergonomic position and for resiliently returning to a straightened condition for contracting the grip into a contracted storage position. Cams or threads or other mechanisms engage the beams for moving them between the expanded and the contracted positions with rotation of a part of the instrument body.
Patent ES-2264923-T3 (ES)
Inventor: MONTANARI THIBAUT
IPC: C08L51/06
Filed: 2000-03-14
Granted: 2007-02-01
Abstract: The composition comprises (in wt.%): polyamide (A1) 50-99, catalyzed polyamide (A2) 1-50, plasticizer 0-40, and flexibility modifier 0-60 (preferably 0-30).
Patent ES-2195863-T3 (ES)
Inventor: PETTUS WILLIAM W
IPC: C09D5/00
Filed: 2000-01-11
Granted: 2003-12-16
Abstract: The present invention relates to a process for producing a durable multi-layered coating on difficult-to-coat substrates, such as aluminum. The process includes subjecting the surface of the difficult-to-coat substrate to a adhesion promoting step, followed by applying an intermediate layer of flexible primer, which contains a polyester copolymer produced through a two-stage polymerization process. A mar resistant top layer of clear coating composition is then applied over the intermediate layer to produce the multi-layered durable coating on the difficult-to-coat substrate. If desired, the intermediate layer may be pigmented or it may be applied in the form of one or more patterned layers of different colors. Alternatively, one or more patterned layers of different colors may be applied over the intermediate layer before the application of the mar resistant top layer. If desired, the application of the mar resistant top layer and the patterned layers may be delayed by up to 12 weeks to permit the user to mass produce coated components, such as delivery van bodies, with an intermediate layer in a basic color, such as white, which can be then custom coated with various design patterns, followed by the application of the mar resistant top layer.
Patent ES-2280206-T3 (ES)
Inventor: KEARNEY DONALD RAYMOND
IPC: A23L33/15
Filed: 2000-03-08
Granted: 2007-09-16
Abstract: Disclosed are beverage products with improved vitamin stability. The beverage products include an effective amount of a aminopolycarboxylic acid as well as an effective amount of a polyphosphate, and can be enriched with one or more vitamins or other nutrients. In one embodiment, the beverage products include added water, fruit juice, ascorbic acid, ethylene diamine tetra-acetic acid (EDTA), sodium hexametaphosphate, and potassium sorbate. The beverage can be packaged in relatively inexpensive HDPE-type containers which are generally oxygen permeable, and do not require the use of special oxygen barrier packaging to preserve the vitamins and flavor oils from oxidation.
Patent ES-2251996-T3 (ES)
Title: Forma cristalina 3 de la sal sodica de 5-cloro-2-metoxi-n-(2-(4-metoxi-3-metilaminotiocarbonilaminosulfonilfenil)etil)-benzamida.
Inventor: ENGLERT HEINRICH CHRISTIAN
IPC: A61P43/00
Filed: 2000-04-04
Granted: 2006-05-16
Abstract: Modificación 3 del cristal de la sal sódica de 5- cloro-2-metoxi-N-(2-(4-metoxi-3- metilaminotiocarbonilaminosulfonilfenil)etil)benzamida, que tiene reflexiones de rayos X en los siguientes ángulos de difracción 2Theta (en º) en los diagramas de difracción de rayos X usando la radiación Ka1 del Cu: reflexiones de rayos X fuertes: 8, 35º, 11, 75º, 11, 95º, 13, 70º, 19, 75º, 20, 90º, 21, 90º, 24, 90º, 26, 40º, 28, 45º; reflexiones de rayos X medias-fuertes: 12, 45º, 15, 80º, 16, 45º, 18, 10º, 18, 45º, 19, 35º, 19, 45º, 21, 40º, 22, 20º, 23, 00º, 25, 15º, 25, 45º, 30, 15º.