baber/WOPTO huggingface dataset:
Patent EA-014558-B1 (EA)
Title: HIGH PURITY 17α CYANOMETHYL-17β-HYDROXY-ESTRA-4,9-DIENE-3-ONE AND PROCESS FOR THE SYNTHESIS THEREOF
Inventor: DANCI LAJOSNE
IPC: C07J41/00
Filed: 2006-10-11
Abstract: The invention relates to a new process for the synthesis of high purity 17α- cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention relates also to the high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one and pharmaceutical compositions containing that as active ingredient. The pharmaceutical compositions according to this invention contain high purity dienogest of formula (I) in which the total amount of impurities is less than 0.1%, while the amount of 4-bromo-dienogest is under the detection limit (0.02%) as active ingredient or at least one of the active ingredients and auxiliary materials, which are commonly used in practice, such as carriers, excipients or diluents. According to our invention the dienogest of formula (I) is synthesized the following way: i) 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V) is reacted with aluminum isopropylate in the presence of cyclohexanone in an inert organic solvent under heating; ii) the so obtained 3-methoxy-estra-2,5(10)-diene-17-one of formula (IV) is reacted with cyanomethyl lithium at a temperature between 0 and -30°C; iii) the obtained 3-methoxy-17α-cyanomethyl-17β-hydroxy-estra-2,5(10)-diene of formula (III) is reacted with a strong organic acid in tetrahydrofuran solution; iv) the obtained 17α-cyanomethyl-17β-hydroxy-estr-5(10)-ene-3-one of formula (II) is reacted with 1-1.5 equivalent of pyridinium tribromide in pyridine solution at a temperature between 0 and 60°C, then the obtained crude dienogest of formula (I) is purified by recrystallization and preparative HPLC.
Patent EA-017085-B1 (EA)
Title: Lyophilized therapeutic peptibody formulations
Inventor: CALLAHAN WILLIAM J
IPC: A61K39/00
Filed: 2007-04-20
Abstract: The present invention provides long-term stable formulations of a lyophilized therapeutic peptibody and methods for making a lyophilized composition comprising a therapeutic peptibody.
Patent EA-017123-B1 (EA)
Title: Process for the production of 2-[4-(3- and 2-fluorobenzyloxy)benzylamino]propanamides
Inventor: BARBANTI ELENA
IPC: A61K31/165
Filed: 2007-06-08
Abstract: A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.
Patent EA-017567-B1 (EA)
Title: Process for purification of an aqueous phase containing polyaromatics
Inventor: DERNONCOURT RENAUD
IPC: C02F1/20
Filed: 2008-11-21
Abstract: The present invention is a process for purifying a liquid stream comprising an aqueous phase and optionally an organic phase, said aqueous phase comprising polyaromatics in solution in water, wherein, a) said liquid stream is sent to a mixing tank in which is introduced an effective amount of an aromatic component, advantageously ethylbenzene or benzene or toluene or mixture thereof to produce a mixture of an organic phase and of an aqueous phase, b) then said mixture recovered at step a) is sent to a decanter to recover a clean aqueous phase and an organic phase, c) then the clean aqueous phase leaving the decanter of step b) goes through a stripper to remove a substantial part of any remaining organic component. According to a specific embodiment the stream sent to step a) is the whole or a fraction of the aqueous phase recovered by condensation of the effluent gas leaving an ethylbenzene dehydrogenation reactor.
Patent EA-017853-B1 (EA)
Title: Active substance combinations
Inventor: STENZEL KLAUS
IPC: A01N43/653
Filed: 2006-05-27
Abstract: The present invention relates to novel active substance combinations containing a known herbicide selected from glyphosate, glufosinate or glufosinate ammonium, on the one hand, and a known fungicide agent on the other and which are very well-suited for controlling unwanted phytopathogenic fungi, particularly soybean rust. Said mixtures are preferably applied to transgenic plants which are resistant to the aforementioned herbicides.
Patent EA-020799-B1 (EA)
Title: Collapsible cassette pavilion for year round bee keeping
Inventor: FISENKO ALEXEY PETROVICH
IPC: A01K47/00
Filed: 2012-08-30
Abstract: The invention relates to providing commercial mass production of cassette pavilions for year round bee keeping. The cassette pavilions permit not to construct winter premises and honeycomb storages, cut the need for other household structures, considerably reduce areas occupied by an apiary and cut substantially labor costs for bee keeping and control bee diseases. The existing models of pavilions are not collapsible but have certain sizes that cannot be changed by the user. The proposed cassette pavilion has a collapsible design and consists of sections having compartments with retractable cassettes for honeycombs. A set of each section comprises a floor, two vertical posts, two side walls with bee entrances, longitudinal and transversal ties for connection posts and strengthening longitudinal and transversal rigidity of the pavilion. Each part of the set is adapted to a collapsible connection with parts adjoined thereto. The posts protrude beyond the pavilion and form ledges from outside for fixing bee in-flying boards and gates for bee entrance and preventing bee wandering. Door panels and heat insulation material at pavilion edges are provided.
Patent EA-024562-B1 (EA)
Title: Method of treating effects of radiation exposure
Inventor: CUNNINGHAM C CASEY
IPC: C07K14/00
Filed: 2010-07-23
Abstract: The present disclosure is directed to methods of administering RLIP76 or an active fragment thereof more than 24 hours after radiation exposure, wherein administration is effective for the protection and treatment of mammals exposed to radiation.
Patent EA-027407-B1 (EA)
Title: Method for hot water supply to a residential building
Inventor: PILIPENKO VLADIMIR MITROFANOVICH
IPC: F24D17/02
Filed: 2013-06-17
Abstract: The invention is related to the field of energy-saving and re-utilization of heat resources and is directed to provision of an independent hot water supply system using heat of spent water from bathroom appliances (shower units and wash stands) in a residential building. The essence of the invention consists in using two-stage heating of cold tap water to a temperature required in the hot water supply system: the first stage - a heat exchanger for preheating of cold tap water; the second stage - a final heating heat exchanger with a hot heat carrier provided by a thermal pump or by the centralized heat supply system. The use of a two-stage water heating system leads to decrease in the required productivity of the thermal pump heat exchanger and to reduction of heat losses in the heat-insulated accumulation tank. For drains from bathrooms, shower units and wash stands, heat-insulated pipelines separate from the common sewerage system are provided, warm drained water is fed through such pipelines to the heat-insulated tank from which warm water is supplied at controllable flow rate to the heat exchanger of primary heating of cold tap water that is also supplied at controllable flow rate and then fed for final heating to the final heating heat exchanger with hot heat carrier from a thermal pump or the centralized heating system, water is heated to the required temperature and then collected in a heat-insulation tank from which it is supplied to consumers through the hot water supply system.
Patent EA-030690-B1 (EA)
Title: Solids injection lance
Inventor: PILOTE JACQUES
IPC: F27B3/18
Filed: 2014-05-02
Abstract: A solids injection lance including (a) a tube that defines a passageway for solid feed material to be injected through the tube and has an inlet for solid material at a rear end and an outlet for discharging solid material at a forward end of the tube, and (b) a puncture detection system for detecting a puncture in the solids injection tube.
Patent EA-032486-B1 (EA)
Title: Improved dehydrogenation process with heat generating material
Inventor: FRIDMAN VLADIMIR
IPC: C07C5/333
Filed: 2015-03-12
Abstract: The present invention provides an improved endothermic hydrocarbon conversion process that comprises reacting hydrocarbons with a multi-component catalyst bed, and regenerating the catalyst bed with air, where the air used in regeneration step and hydrocarbon are at low air to hydrocarbon ratios and optionally at near-atmospheric pressures.
Patent EA-034530-B1 (EA)
Title: Removal of serine proteases by treatment with finely divided silicon dioxide
Inventor: TESCHNER WOLFGANG
IPC: A61K35/16
Filed: 2011-05-26
Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having a reduced serine protease and/or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having a reduced serive protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
Patent EA-038483-B1 (EA)
Title: Method and apparatus for monitoring nutrition, especially fermentation in a rumen of a ruminant
Inventor: LAPORTE URIBE JOSE ALBERTO
Filed: 2015-02-10
Abstract: Method for monitoring nutrition, especially fermentation in a rumen of a ruminant, wherein a characteristic value of carbon dioxide inside the rumen and/or reticulum is determined. A bolus system (1) is provided for measuring dissolved carbon dioxide in the rumen of the ruminant, such as a dairy cow, using a near dispersive infrared sensor (2). Dissolved CO2 is correlated with pH and rumen acidosis can be detected. The bolus (1) is permanently implanted in the rumen and data are transmitted wirelessly. The system can be used in a milking parlor.
Patent EA-037537-B1 (EA)
Title: Device for isolating cell fractions from human and animal tissues and method for the use thereof
Inventor: VEREMEYEV ALEKSEY VLADIMIROVICH
IPC: C12M1/12
Filed: 2015-11-03
Abstract: The invention relates to medical biotechnology and cell technology. Proposed is a method for isolating stromal vascular fraction of adipose tissue, which includes: decantation of a lipoaspirate; delicate washing of the lipoaspirate in buffer solutions; enzymatic treatment using a mixture of collagenases, thermolysin, dispase and trypsin at a temperature of 37ºC; centrifugation at 500-2000 g and filtration through microfilters with a pore size of 10-300 m with the subsequent removal of fat and stromal tissue matter; repeat washing, and concentration of the cell fraction, wherein all of the stages of the process are carried out under closed system conditions. A corresponding device is configured as a sealed container consisting of two chambers, which are separated from one another by nylon microfilters with pore sizes of 10-500 m. The device comprises fittings, provided with valves, and channels for the introduction and removal of biological tissue and a cellular end product for subsequent administration. Owing to the presence of a cocktail of mature and progenitor cells in stromal vascular fraction, which have a paracrine effect, the sterility of all of the stages of the process and the safety thereof, the claimed method can be used in medicine for the cell-based therapy and regeneration of organs and tissues, including: soft tissue and bone regeneration, and the treatment of cosmetic defects, chronic trophic and radiation ulcers, burns, Crohn's disease, multiple sclerosis, graft-versus-host reactions, myocardial infarction and strokes of different origins.
Patent EA-038115-B1 (EA)
Title: Therapeutically active composition for treatment of hsv-1 and/or hsv-2 infection, method for preparing same and method of therapeutic treatment of hsv-1 and/or hsv-2 infection using same
Inventor: WILMOTTE REMI
IPC: A61P31/22
Filed: 2017-03-29
Abstract: The invention relates to therapeutically active compositions provided for the therapeutic treatment of an HSV-1 and/or HSV-2 infection. For example, such composition can comprise at least one metal salt chosen from molybdenum (Mo), tungsten (W), vanadium (V) and gold (Au); at least one chelating agent; at least one source of peroxidative radicals; at least one buffer agent. The composition has a redox potential from 250 to 550 mV. Also provided are pharmaceutical compositions comprising such therapeutically active composition. These composition find application in a method of the therapeutic treatment of an HSV-1 and/or HSV-2 infection.
Patent EA-039773-B1 (EA)
Title: Personal care compositions with glutathione precursor comprising nicotinamide and amino acids
Inventor: GUELAKIS MARIAN PEREIRA
Filed: 2017-12-18
Abstract: Provided are topical personal care compositions, comprising: a. glutathione precursor comprising, by weight of the composition: i. from 0.001 to 2 wt.% of cystine or a salt or ester thereof; ii. from 0.01 to 5 wt.% of a glutamate source; iii. from 0.01 to 5 wt.% of glycine; and iv. from 0.01 to 5 wt.% of nicotinamide; and b. a cosmetically acceptable carrier in the form of a water and oil emulsion; wherein the pH of the composition is in the range of from 3.5 to 8.5; and wherein the weight ratio of nicotinamide to the total amount of amino acids is from 20:1 to 50:1. Said compositions are provided for potentiating glutathione synthesis within skin cells. Also provided are methods of improving the appearance of skin and attaining even skin color and reducing pigmentation, age spots and discoloration, comprising applying to the skin said compositions.
Patent ES-2181531-B1 (ES)
Title: Mejoras introducidas a la patente de invencion n. 200001062 relativa a una disposicion de puerta blindada e ignifuga perfeccionada.
Inventor: SERRANO COLADO RAFAEL MARTIN
IPC: E06B5/16
Filed: 2000-04-28
Granted: 2003-12-16
Abstract: Mejoras introducidas a la Patente de Invención n°. 200001062, relativa a una disposición de puerta blindada e ignifuga perfeccionada (1), que consiste en la inclusión de una capa (8) de aglomerado dotado de aditivos ignífugos posicionada en torno al núcleo (9) de aglomerado, determinando el cuerpo central de la hoja (2), sobre cuyos laterales se posicionan las láminas de acero (6) con tornillos (7), las capas de fibra (5) y (4), y las láminas decorativas (3), haciendo uso de capas (10) para cubrir las caras delantera y trasera, disponiendo de rebajo del cerco (13) con junta intumescente (11), junta estanca ignífuga (12), fibra hidrófuga (14) rechapada en chapa de madera, existiendo una junta intumescente (11) en la hoja (2).
Patent ES-2187241-B1 (ES)
Title: Procedimiento para la produccion de isocianatos.
Inventor: CASTILLON MIRANDA SERGIO
IPC: C07C265/12
Filed: 2000-06-01
Granted: 2004-08-01
Abstract: Procedimiento para la producción de isocianatos. El procedimiento comprende la descomposición térmica catalítica de un carbamato en presencia de silicatos naturales o sintéticos como catalizadores. Se forman selectivamente isocianatos con altos rendimientos y elevadas velocidades de reacción.
Patent ES-2178958-B1 (ES)
Title: Cierre para pinchos o tapas rellenas.
Inventor: BERECIARTUA ACHAGA JOSE ANTONI
IPC: A23L35/00
Filed: 2001-02-15
Granted: 2004-06-16
Abstract: Cierre para pinchos o tapas rellenas, estructurado en un cuerpo o porción varillada comestible que, siendo rígida, al menos originariamente, se ensarta en el envolvente o porción-funda comestible ocluyendo su(s) extremo(s) o bocas admisoras de relleno, para así retener en su interior a la masa o relleno, también comestible. De aplicación en productos comestibles preparados para ser consumidos como pinchos o tapas.
Patent ES-2178966-B1 (ES)
Title: Sistema de control del nivel de un deposito.
Inventor: SALAS GIMENEZ LLUIS
IPC: G05D9/12
Filed: 2001-05-08
Granted: 2004-06-16
Abstract: Sistema de control del nivel de un depósito. Comprende medios (2) de detección de dicho nivel, y se caracteriza por el hecho de que comprende también un circuito electrónico (4) receptor de la señal generada por los medios (2) de detección y emisor de una señal hacia un dispositivo receptor (9) dispuesto a distancia, de modo que cuando los medios (2) de detección del nivel del depósito (1) detectan que el nivel del mismo se encuentra en un nivel predeterminado, envían una señal al circuito electrónico (4) receptor-emisor, el cual emite una señal hacia el dispositivo receptor (9). Se consigue un sistema que permite conocer a distancia si el producto almacenado en dicho depósito se encuentra por debajo de un nivel mínimo, indicador de que el depósito está vacío, si se encuentra por encima de un nivel predeterminado, o si se encuentra por encima de un nivel máximo, indicador de que el depósito está totalmente lleno.
Patent ES-2209573-B1 (ES)
Title: Procedimiento de fabricacion de tapizado, en especial para asientos de vehiculo.
Inventor: LUCIA MONFORTE PEDRO
IPC: B29C44/14
Filed: 2001-07-02
Granted: 2005-03-01
Abstract: Procedimiento de fabricación de tapizado, en especial para asientos de vehículo. El asiento (1) está constituido por zonas convexas (2) y zonas cóncavas (3) y el tapizado constituido por tres capas; una capa exterior (4) de revestimiento, una capa interior (5) a base de espuma y una capa intermedia (6) de film, y se caracteriza por el hecho de que la capa (6) de film se adhiere a la capa interior (5) y a la capa exterior (4) en las zonas cóncavas (3) del asiento y por el hecho de que dicha capa exterior (4) o interior (5) se separa de la capa de film (6) en las zonas convexas (2). Se mejora la flexibilidad en las zonas convexas (2) del asiento (1), incrementando la durabilidad y evitando la formación de arrugas permanentes.
Patent ES-2199656-B1 (ES)
Title: Unidad de radiador para vehiculo.
Inventor: KENJI OKI
IPC: F02B61/02
Filed: 2001-10-22
Granted: 2005-05-16
Abstract: Unidad de radiador para vehículo. Objeto: en una unidad de radiador para un vehículo incluyendo un radiador, que está provisto, en la parte superior, de un tapón de suministro de agua que se abre o cierra mediante una operación rotativa y está montado en un vehículo, y una cubierta de radiador que cubre el radiador por fuera y está montada en el radiador, el objeto de la presente invención es evitar el aumento del número de piezas, mejorar la operación de montaje, y además mantener el tapón de suministro de agua en la posición cerrada. Medios de solución: Una parte reguladora de posición 74a, que se engancha con el tapón de suministro de agua 88 en una posición cerrada para poder montar la cubierta de radiador 74 en el radiador 72 y evita que el tapón de suministro de agua 88 gire a una posición abierta, está montada integralmente en la cubierta de radiador 74 de tal manera que cubra el tapón de suministro de agua 88.
Patent ES-2211264-B1 (ES)
Title: Generador electrico formado por bolas que caen por un tubo golpeando bielas horizontales.
Inventor: PORRAS VILA FCO JAVIER
IPC: B32B17/10
Filed: 2001-01-16
Granted: 2005-09-16
Abstract: El generador eléctrico formado por bolas que caen por un tubo, golpeando bielas horizontales, es un aparato que funciona a partir de la acción del movimiento que unas bolas transmiten; al ir cayendo por un tubo vertical, a unas bielas que mueven discos de cobre o rotores de imanes. Tiene el objetivo de crear energía eléctrica y genera su propio movimiento a partir de la fuerza de gravedad. El sistema consta de dos partes bien diferenciadas que son: un tubo con bielas que irrumpen horizontalmente en el hueco, y una especie de canal en forma de "serpentín" que se va doblando, en horizontal y sobre sí mismo, en las esquinas, a la vez que asciende, mientras que desciende un poco por el recorrido de la canal que es suficientemente largo para que la bola adquiera el impulso necesario para remontar el nuevo tramo. De este modo, las bolas van subiendo poco a poco hasta la parte más alta del sistema desde donde comienzan a descender de nuevo por el tubo.
Patent ES-2230938-B1 (ES)
Title: Dispositivo reductor removible de radiaciones gamma.
Inventor: LLEONART SUAREZ ALEJANDRO
IPC: G01T1/24
Filed: 2002-03-23
Granted: 2007-04-01
Abstract: Dispositivo reductor removible de radiaciones gamma, que consiste en un cuerpo (2) fabricado en resina transparente, que incorpora dos leds luminosos (4) y un chip (3), disponiendo en la parte opuesta al cuerpo de resina (2) de una superficie (5) de material adhesivo removible.
Patent ES-2245143-B1 (ES)
Title: Expositor con paneles deslizantes de frente intercambiable, para mobiliario y accesorios de cocinas y baños.
Inventor: VICENTE SORIANO M AMPARO
IPC: A47F5/08
Filed: 2002-05-03
Granted: 2007-04-16
Abstract: El objeto de esta Patente es un "Expositor de paneles deslizantes, de frente intercambiable, para mobiliario y accesorios de cocinas y baños", cuyo uso aparece explícito en el propio enunciado de la invención. Los órganos de guiado son perfiles U invertidos (1) por cuyo interior deslizan pletinas (2) de canto, unidas al lado superior del bastidor, en cuyo borde superior disponen de rodamientos (3) de giro horizontal que presentan una separación (7) de la rama transversal del perfil U. El peso de cada panel se transmite a través de cojinetes (4) a ejes (5) montados con sendos rodamientos (6) en sus extremos. Los lados verticales interiores de los bastidores, disponen de alas (8) salientes lateralmente que hacen tope con pletinas verticales (9) que fijan los limites del deslizamiento de avance o retroceso de los paneles. Las partes frontales de los elementos exhibidos, se fijan de forma amovible, por adherencia magnética, a pletinas horizontales (10) dispuestas en la cara frontal de los paneles.
Patent ES-2184654-B1 (ES)
Title: Procedimiento para la elaboracion de cecina de chivo de vegacervera.
Inventor: GARCIA ARIAS MARIA TRINIDAD
IPC: A23L13/70
Filed: 2002-10-08
Granted: 2004-04-01
Abstract: Procedimiento para la elaboración de cecina de chivo de Vegacervera". Se describe un procedimiento para la elaboración de productos conocidos como "cecina de chivo de Vegacervera", que comprenden la pierna, la paletilla y los costrabazos delantero y trasero del ganado caprino. El procedimiento comprende varias fases sucesivas, entre las que se incluye una fase de salado; una fase de lavado, escurrido y adobado; una fase de colgado y ahumado, y una última fase de secado-curación. Las distintas fases se llevan a cabo en condiciones controladas de temperatura y humedad relativa, mientras que como material de adobo se utiliza una mezcla compuesta por agua, pimentón dulce, aceite de oliva y ajo.