baber/WOPTO huggingface dataset:
Patent CR-20140476-A (CR)
Title: Agentes para tratar transtornos que implican la modulación de receptores de rianodina
Inventor: YAN JIAMING
IPC: C07D281/10
Filed: 2014-10-14
Abstract: La presente invención se refiere a derivados de 1,4-benzotiazepina y a su uso para tratar afecciones, trastornos y enfermedades asociadas con los receptores de rianodina (RyR) que regulan el funcionamiento del canal de calcio en las células.
Patent CR-20150037-A (CR)
Title: Aparatos y técnicas para la colocación subterránea de uno o más elementos
Inventor: CASSELL RONALD L
IPC: A01C15/02
Filed: 2015-01-27
Abstract: Se proveen aparatos y técnicas para la colocación subterránea o el posicionamiento de uno o más elementos.
Patent CR-20230147-A (CR)
Title: Preparación y almacenamiento de formulaciones de rna liposomal adecuadas para terapia
Inventor: HILLER THOMAS MICHAEL
IPC: A61K31/7105
Filed: 2021-09-30
Abstract: La presente divulgación se refiere a métodos para preparar partículas de lipoplexo de RNA para suministrar RNA a tejidos diana después de la administración parenteral, en particular después de la administración intravenosa, y composiciones que comprenden tales partículas de lipoplexo de RNA. La presente divulgación también se refiere a métodos que permiten preparar partículas de lipoplexo de RNA de una manera que cumple con las GMP industriales. Además, la presente divulgación se refiere a métodos y composiciones para almacenar partículas de lipoplexo de RNA sin pérdida sustancial de la calidad del producto y, en particular, sin pérdida sustancial de la actividad del RNA.<br /> <br />
Patent EC-SP045254-A (EC)
Title: Derivados de indolilmaleimida
Inventor: EVENOU JEAN PIERRE
IPC: A61P37/02
Filed: 2004-08-27
Abstract: Se proporcionan compuestos de la fórmula (I), los cuales son útiles en el tratamiento y/o prevención de enfermedades o desórdenes mediados por linfocitos T y/o PKC, por ejemplo, rechazo agudo o crónico de alo- o xenoinjertos de órgano o tejido, enfermedades de injerto contra huésped, ateroscleorisis, oclusión vascular debido a daño vascular tal como angioplastía, restenosis, obesidad, síndrome X, tolerancia dañada a glucosa, síndrome de ovario poliquístico, hipertensión, falla cardiaca, enfermedad pulmonar obstructiva crónica, enfermedades del CNS tales como enfermedad de Alzheimer o esclerosis lateral amiotrófica, cáncer, enfermedades infecciosas tales como SIDA, choque séptico o síndrome de dificultad respiratoria en adultos, daño por isquemia/reperfusión, por ejemplo, infarto al miocardio, choque, isquemia de intestinos, falla renal o choque hemorrágico, o choque traumático, por ejemplo, daño traumático del cerebro. Los compuestos de (I) también son útiles en el tratamiento y/o prevención de enfermedades o desórdenes inflamatorios agudos o crónicos mediados por célula T o enfermedades autoinmunes, por ejemplo, artritis reumatoide, osteoartritis, lupus sistémico eritematoso, tiroides de Hashimoto, esclerosis múltiple,miastenia grave, diabetes de tipo I o II y los deórdeenes asociados con las mismas, por ejemplo, antipatía, retinopatía proliferativa diabética, edema macular diabético, nefropatía, neuropatía y síndrome de Dawn, enfermedades respiratorias tales como asma o daño inflamatorio del pulmón, daño inflamatorio del hígado, daño inflamatorio glomerular, manifestaciones cutáneas de enfermedades o desórdenes inmunológicamente mediados, enfermedades inflamatorias e hiperproliferativas de la piel (tales como psoriasis, dermatitis atópica, dermatitis alérgica de contacto, dermatitis irritante de contacto y otras dermatitis eczematosas, dermatitis seborréica), enfermedades inflamatorias de los ojos, por ejemplo, síndrome de Sjegren, queratoconjuntivitis o uveítis, enfermedad inflamatoria del intestino, enfermedad de Crohn o colitis ulcerativa.
Patent EC-SP056240-A (EC)
Title: Derivados de pirido[2,1-a]isoquinolina como inhibidores de dpp-iv
Inventor: BOEHRINGER MARKUS
IPC: C07D471/04
Filed: 2005-12-20
Abstract: La presente invención se refiere a compuestos de la fórmula (I) en la que R1, R2, R3 y R4 tienen los significados definidos en la descripción y en las reivindicaciones, y a sales farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento y/o profilaxis de enfermedades asociadas con la DPP-IV, por ejemplo diabetes, en particular la diabetes mellitus no dependiente de la insulina y el trastorno en la tolerancia de la glucosa.
Patent EC-SP066512-A (EC)
Title: Formulación y método de aripiprazol inyectable estéril de liberación controlada
Inventor: KOSTANSKI JANUSZ W
IPC: A61K31/496
Filed: 2006-04-18
Abstract: Se provee una formulación de aripiprazol secada por congelación estéril de liberación controlada, que está formada de aripiprazol de un tamaño de partícula promedio deseado y un vehículo del mismo, el cual después de la constitución con agua e inyección intramuscular libera aripiprazol durante un período de por lo menos una semana y hasta alrededor de 8 semanas. También se proporciona un método para preparar la formulación de aripiprazol secada por congelación de liberación controlada, y un método para tratar esquizofrenia mediante el uso de la formulación anterior.
Patent EC-SP088966-A (EC)
Title: Agonistas del receptor muscarínico que son efectivos en el tratamiento del dolor, la enfermedad de alzheimer y la esquizofrenia
Inventor: TOMASZEWSKI MIROSLAW
IPC: A61K31/454
Filed: 2008-12-12
Abstract: Compuestos de Fórmula I, o sales farmacéuticamente aceptables de los mismos: donde A1, A2, G1, G2, G3, R1, R2, X, Y, Z, m, n y p son como los definidos en la descripción así como sales y composiciones farmacéuticas que incluyen los compuestos son preparados. Estos son útiles en terapia, en particular en el manejo del dolor.
Patent EC-SP941116-A (EC)
Title: 17 b-carbamoil-n-monosustituido-4-aza- 5- alfa androst -1-en -3-onas, que son activas como inhibidores de la testosterona -5 - alfa reductasa
Inventor: RASMUSSON GARY H
IPC: C07J73/00
Filed: 1994-07-08
Abstract: El compuesto 17 beta (N-t-butilcarbamoilo)-4-aza-5 alfa-androst-1-en-3-ona.
Patent EC-SP972127-A (EC)
Title: Aparato y metodo de despepitado de algodón
Inventor: PAYNE TREVOR
IPC: D01B1/04
Filed: 1997-05-22
Abstract: La invención se refiere a un método y aparato para despepitar algodón en rama cosechado, que consiste de los pagos siguientes: introducción del algodón en rama cosechado incluyendo borra y semilla en la parte superior de una placa inferior giratoria; la rotación de dicha placa para asi llevar el algodón en rama cosechado hacia el borde anterior de una cuchilla colocada a una distancia definida sobre dicha placa inferior giratoria de manera que el algodón en rama se lleve/peine bajo el borde de la cuchilla; extracción de la borra separada del algodón en mara indicando del borde dirigido hacia atras de dicha cuchilla; y, recolección de la semilla del borde delantero de la cuchilla.
Patent EC-SP982373-A (EC)
Title: Inhibidores de sulfamidas- metaloproteasas
Inventor: CAMPBELL JEFFREY ALLEN
IPC: C07C311/00
Filed: 1998-01-22
Abstract: Este invento se refiere a sulfamidas de la fórmula (I) (gráfico) en donde R1, R2, R3, R10, R20, R21 son como se ha definido en la memoria y reivindicaciones que son inhibidores de metaloproteasas, composiciones farmacéuticas que las contienen, métodos para su empleo y métodos para la preparación de estos compuestos.
Patent EC-SP982636-A (EC)
Title: Derivados de n-alcanoilofenilalanina
Inventor: SIDDURI ACHYUTHARAO
IPC: C07C233/45
Filed: 1998-08-21
Abstract: Un compuesto de la fórmula en donde: uno de X y X¿ es hidrógeno, halógeno, o alquilo inferior, el otro es un grupo de la fórmula: en donde R1 es hidrógeno o alquilo inferior, R15 es halógeno, nitro, alquil sulfonilo inferior, ciano, alquilo inferior, OH, alcoxilo inferior, alcoxicarbonilo inferior, carboxilo, alquil aminosulfonilo inferior, perfluoro alquilo inferior, alquiltio inferior, hidroxi alquilo inferior, alcoxi alquilo inferior, halo alquilo inferior, alquiltio alquilo inferior, alquilsulfinil alquilo inferior, alquilsulfonil alquilo inferior, alquilsulfinilo inferior, alcanoilo inferior, aroilo, ariloxilo un grupo de la fórmula R17 CºC-, R16 es hidrógeno, halógeno, nitro, ciano, alquilo inferior, OH, perfluoro alquilo inferior o alquiltio inferior, R17 es hidrógeno, arilo, heteroarilo o alquilo inferior que está insustituido o sustituido por OH, arilo o heteroarilo, y a es 0 o 1.
Patent EG-23049-A (EG)
Title: Process for the reduction of elimination of hydrogen sulphide
Inventor: SMITH HUBERN L
IPC: C10L3/10
Filed: 2001-12-26
Granted: 2004-01-31
Abstract: The invention provides a process for reducing the level of hydrogen sulphide in a liquid or gas by treatment of the liquid or gas with an H<SUB>2</SUB>S-scavenger product derivable by the reaction of a carbonyl group-containing compound with an alcohol, thiol, amide, thioamide, urea or thiourea. The carbonyl group-containing compound is preferably formaldehyde, and preferably the product is derivable by reaction of formaldehyde with an amine-free alcohol or urea selected from ethylene glycol, propylene glycol, glycerol, diethylene glycol, triethylene glycol, ethyl alcohol, n-butanol, a sugar, a low molecular weight polyvinyl alcohol, castor oil fatty acid and urea. More especially, the scavenger product is used with an amine, especially monoethanolamine.
Patent FR-1604735-A (FR)
Title: Concentrating coffee or tea extracts - by partial freezing with recovery of solids adhering to ice
IPC: A23F5/26
Filed: 1968-12-26
Granted: 1972-01-24
Abstract: Loos of coffee or tea components is reduced by recovering material adhering to ice, when the latter is separated from the concentrated extract after the partial freezing. The separated ice is melted or washed, and the resulting dilute soln. contg. components of coffee or tea is concentrated or recycled to the extraction stage.
Patent GB-1053844-A (GB)
IPC: C07C57/50
Abstract: 1,053,844. Acetic acid derivatives. KONINKLIJKE PHARMACEUTISCHE FABRIEKEN V/H BROCADES - STHEEMAN & PHARMACIA N.V. Sept. 16, 1964 [Sept. 16, 1963], No. 37888/64. Divided out of 1,053,843. Heading C2C. The invention comprises compounds of the general formula wherein X represents a -CH 2 -CH 2 - or a -CH=CH- group and R 1  and R 2  each represent a hydrogen or a halogen atom or a straight or branched chain alkyl group of less than eight carbon atoms. The compounds may be prepared either by reacting a ketone of the formula with acetylene in the medium of liquid ammonia and in the presence of a condensing agent, to yield a compound of the formula isomerizing this compound by treatment under the conditions of the Meyer-Schuster reaction to give an aldehyde of the formula oxidizing this to the unsaturated acid of the formula and hydrogenating the double bond in the 5- position; or by reducing a ketone II to form an alcohol, converting this to a nitrile with cyanoacetic acid and saponifying VI in an alkaline medium; or by reducing II to the alcohol forming the compound reacting VII with a compound of the formula wherein n is 1 or 2, R 3  is a lower alkyl group, and M is an alkali metal atom if n= 1 or an alkaline earth metal atom if n=2, hydrolysing the metal complex and saponifying the resultant ester to yield a malonic acid derivative of the formula and decarboxylating IX; or by reacting a compound of Formula VII with a metal derivative of ethyl acetoacetate to yield a compound of the formula and reacting X with alcoholic alkali metal hydroxide; or by reducing II to the alcohol, reacting this with malonic acid and decarboxylating the resulting malonic acid derivative.
Patent GB-1054016-A (GB)
IPC: D04H11/00
Abstract: 1,054,016. Coated fabrics. HERCULES Inc. Sept. 17, 1965 [Sept. 17, 1964], No. 39717/65. Heading B2E. [Also in Division C3]. In a process for electrostatically flocking fibres of stereoregular polypropylene, fibre flock having incorporated therein 0.5 to 2.0 weight per cent of titanium dioxide or zinc sulphide is sifted on to an adhesive coated substrate in the presence of an electrostatic force field between the sifting means and the substrate. The flock fibres may be treated with an antistatic agent. e.g. a quaternary ammonium salt or polyalkylene glycol. In examples polypropylene filaments containing various proportions of titanium dioxide and zinc sulphide, and treated with a quarternary ammonium salt antistatic agent, are cut to lenghs of 3000 microns and supplied to a sifter having a rotating blade to force the flock through the sifting screen on to a fabric coated with a heat curable adhesive and passing over a metal plate located below the sifter, an electrical potential difference being maintained between the plate and the sifter.
Patent GB-1225541-A (GB)
IPC: G03F7/06
Filed: 1968-05-02
Abstract: 1,225,541. Photo-lithography. EASTMAN KODAK CO. May 2, 1968 [May 3, 1967], No.20813/68. Heading G2C. Photo-sensitive materials for preparing lithographic plates comprise (i) a support, (ii) a surface layer of a silver halide emulsion in a tannable hydrophilic colloid, the layer being photo-sensitive or non-photo-sensitive and optionally being fogged, (iii) a silver halide developing agent (optionally in the form of a precusor) capable of oxidation in the presence of the tannable hydrophilic colloid to form an image receptive to lithographic printing ink, (iv) if the surface layer is not photo-sensitive, silver halide emulsion layer between the surface layer and the support, and (v) a layer containing a metal oxide and having an average reflectance of at least 60% to light in the region 420-500mpl, which layer is either between the photo-sensitive layer and the adjacent surface of the support or forms the said surface of the support. The materials are similar to those described in Specification's 978,744 and 1,223,334 (apart from the metal oxide layer) and are processed in the same way. Preferably, the oxide is ZnO, TiO 2 , MgO or Al 2 O 3 , and is present in a colloid layer or in a polymer coating on the support; the oxide layer may also contain an antihalation dye, e.g. 1, 5-di-(3, 4-dipydroxy-benzoyl)-penta-1, 3- dienylene-bispyridinium chloride, mono-inner salt.
Patent GB-1229751-A (GB)
IPC: G03B11/04
Filed: 1969-01-03
Abstract: 1,229,751. Lens hoods. STUDIOUL CINEMATOGRAFIC BUCURESTI. Jan. 3 1969, No. 517/69. Heading G2A. A hood 1 can be attached to a camera lens by a fitting 2, and has a slot a in which a colour filter 3 can be inserted. Within the hood are light sources 4, 4<SP>1</SP>, screened from the lens by shields 5, 5<SP>1</SP>, which illuminate the filter from behind, and so produce an predominating colour effect on whatever is being photographed by the camera.
Patent GB-1233754-A (GB)
IPC: H04M15/04
Filed: 1968-12-19
Abstract: 1,233,754. Automatic exchange systems. C.I.T.-COMPAGNIE INDUSTRIELLE DES TELECOMMUNICATIONS. 19 Dec., 1968 [21 Dec., 1967], No. 60519/68. Heading H4K. Calls between a calling line circuit AR and a called line circuit AE are metered with supervision from a junctor C by accumulating call data in a storage compartment of a store M the compartments of which are associated with the junctors C, access to the store M being governed by a controller N. A register E seized for a call applies to N for access to store M and, by reverting a mark back over the junctor C in use for the call, effects an identification of the calling line from identifier ID. The identity thus presented by ID is written in store M in a compartment associated with the junctor. When the called subscriber's identity is registered in E and passed to a route-finder IA, the controller N is again applied to for permission for the route finder to record the called subscriber's identity in the compartment of M associated with the junctor the identity of which is indicated to the store M by a backward mark from the register E to the junctor which thereby marks itself as a coded input to the store M. When the called subscriber replies the register E applies to N to record from a clock MT the time at which metering starts along with the charging rate. Release is detected at the junctor C which applies to N for a record of the time of release from clock MT. When release time is recorded the junctor C applies to a so-called translator T which, with permission of the controller N, reads out from M all the data relating to the call just released and converts it to data on a punched tape for subsequent processing in an accounts department.
Patent GB-1238177-A (GB)
IPC: C04B35/05
Filed: 1968-08-05
Abstract: 1,238,177. Magnesia-chrome refractories. VEITSCHER MAGNESITWERKE A.G. 5 Aug., 1968 [4 Aug., 1967], No. 37322/68. Heading CIJ. A basic refractory material is obtained by melting down ferrochrome (preferably 2-30%) with caustically calcined or sintered magnesia containing at least 90% MgO, not more than 6% FeO and not more than 2% SiO 2 . The fusion can be directly cast into the required body, or crushed and the granules processed to form the body.
Patent GB-1238407-A (GB)
IPC: B01J2/00
Filed: 1969-07-03
Abstract: 1,238,407. Measuring fluid-flow; viscometers. H. J. WOOCK. July 3, 1969, No.33700/69. Headings G1R and G1S. [Also in Divisions B1-2] Viscosimeters: In a slurry mixing area circulating apparatus (see Division B1-2) the viscosity of the slurry is sensed by discharging it from the end 71, Fig.6, if a flexible tube 19 so that it flows completely over a tear-drop shaped body 69. A continuous coating of solids is deposited in the body, the thickness of the coating being dependant on the viscosity of the slurry, and being sensed by a balance beam 66 which operates control switches 74, 75. The rate of flow through the device is adjustable by removing tube end 71 along the stem 70 by means of nut 72. Fluid-pressure gauges: The rate of flow through the mixing apparatus is sensed by discharging slurry from a flexible tube 90, Fig. 7, against the wall of a container 10. The reaction of the jet moves the tube which is supported by a weight 80 attached to arms 81, 84 which pivot about a point 82, causing a cord 85 to rotate a drum 86 and move a pointer 87 against indicia 89.
Patent GB-1238838-A (GB)
IPC: E21C35/18
Filed: 1969-09-20
Abstract: 1,238,838. Coal cutter picks. TUNGSTEN CARBIDE DEVELOPMENTS Ltd. 20 Sept., 1969, No. 46432/69. Heading E1F. A shanked, carbide-tipped coal cutter pick has a radiused periphery at both the top face and front face of the head, and both the front face 8 of the cutting tip and an adjacent portion 5 of the front face of the head are formed with negative rake. The portion 4 of the front face beneath the upper portion is formed with a positive rake.
Patent GB-1251516-A (GB)
IPC: C09K3/00
Filed: 1968-10-30
Abstract: 1,251,516. Diatomaceous earth. KIESELGUHR DE MEXICO S.A. 30 Oct., 1968 [30 Oct., 1967], No. 51530/68. Heading C1A. A diatomaceous earth with an oil absorbency of 230 gm. of oil per 100 gm. of earth claimed per se is prepared by purifying a diatomaceous earth by contacting it with a polyelectrolyte. Suitable polyelectrolytes include polysaccharids, polyarylamides, acrylamide polymer hydrolytes, carboxymethyl celluloses, guar gums and alginates. Preferably 5 to 1000 parts by weight of polyelectrolyte are used per million parts of earth and the earth should have a moisture content of at least 5% during the treatment. The polyelectrolyte may be in aqueous solution at a concentration less than 0À05% by wt. and the earth preferably has a diatom content of at least 8% by wt. After the treatment, the earth is calcined at 950 to 1500 C. In the embodiment shown in Fig. 1, raw diatomaceous earth is fed to a hammer mill 1 and then to a dryer 2. After drying the material is fed to hammer mill 3. The mater al is then classified and fed to the polyelectrolyte reactor 7. The treated material is fed to a hammer mill 8, a calciner 9, rotary cooler 10, hammer mill 11 and air classifier 12 respectively.
Patent GB-1252674-A (GB)
IPC: B60T8/74
Filed: 1969-02-18
Abstract: 1,252,674. Anti-skid systems. CAM GEAKS Ltd. 18 Feb., 1969, No. 8699/69. Heading F2F. An anti-skid braking device for fluid pressure vehicle brakes, comprises in combination an inertial mass 7 rotatably mounted on a spindle 5 which is rotated with a vehicle wheel and is given axial movement when there is relative rotation between the mass and the spindle, a braking fluid control valve 11 operated in accordance with such axial movement, a pressure accumulator 15, and fluid connectors all so arranged that operation of the valve caused inertially by predetermined rotational deceleration of the vehicle wheel relieves the fluid pressure applied to the brake servomotor 2 of such wheel by connecting the pressure source and the brake servomotor to the pressure accumulator. As shown, the spindle 5 is driven by a frictionally driven wheel 4 in engagement with the brake disc 1 of a caliper-type brake, the flywheel 7 being screwed on to the spindle and housed in a body 6 including a cylinder 9 for the valve 11 which is urged towards the flywheel by a preset or selected spring 12 adjustable by externally accessible means or shims. When the wheel associated with the wheel 4 stops with rapid deceleration, the flywheel moves to the right as seen in the Figure and a push rod 10 moves the valve so that duct 12A is opened via ducts 9A, 14 and 14A to the accumulator, the pressure in the line 3 being reduced and the wheel, previously skidding, being released; the flywheel screws back along the spindle 5. Upon release of pressure in the line 3 the fluid in the accumulator is discharged via restriction 14E and valve 14D to the line. In a modification, the cylinder 9 is directly ducted to the line 3 and to the master brake cylinder, the valve, upon being shifted to the right, connecting the line 3 to the accumulator. The flywheel may be driven on or from a transmission shaft to respond to locking of a pair of wheels driven through a differential, and the spindle may be driven by a cable.
Patent GB-1252958-A (GB)
IPC: E21B47/06
Filed: 1969-06-04
Abstract: 1,252,958. Measuring pressure electrically. TEXACO DEVELOPMENT CORP. June 4, 1969, No.28318/69. Heading G1N. Apparatus for measuring pressure of mud in a borehole comprises a drill bit 12 on a drill string, which bit includes a diaphragm or piston 52 communicating through an oil-filled conduit 54, 44, with a strain-gauge 56 from which electrical signals are passed to a magnetic tape recorder capsule (16) Fig.2a (not shown), in the drill string. The apparatus includes unspecified means for recording the speed and/or depth of the bit in the borehole. It is stated that the rate of change of pressure may be derived from the pressure signal and recorded. (For Figures see next page)
Patent GB-1264245-A (GB)
IPC: B28B19/00
Filed: 1969-06-30
Abstract: 1,264,245. Coating pipes. TREST KIEVPODZEMDORSTROI N I GLAVKIEVGORSTROYA. 30 June, 1969, No. 32951/69. Heading B2L. An installation for coating the outside surface of a pipe with concrete comprises a track way 4 and supports 5 for the pipe 17, a carriage 2 movable on the trackway and carrying coating means. The end support 5' is  lockable to prevent rotation of the pipe 17 and the support 5 are lowerable to allow the coating applicator to pass. Concrete passes through the hopper 12 and is fed by rollers 13 to auger 9 which applies the concrete. Means may be provided for wrapping the coated pipe with polyvinyl chloride film. The track has two long straight sections, over which pipes are supported, joined at their ends by curved sections to produce a continuous circuit.