baber/WOPTO huggingface dataset:
Patent CA-2208206-A1 (CA)
Title: Composition for treating tumors comprising lactose and a saccharide conjugate of a cytotoxic phenolic compound
Inventor: RUBIN DAVID
IPC: A61K31/05
Filed: 1995-11-27
Abstract: Metastasization of malignant tumors can be inhibited by administering to a patient in need thereof sufficient lactose to block crucial lectins on the affected organ so that the tumor cells cannot anchor to other locations in the body. Lactose can be administered alone, or in combination with conjugates of cytotoxic drugs. Preferably, lactose is conjugated to a cytotoxic substance so that the primary tumor is treated concurrently with prevention of metastasis. Additionally, by conjugating a cytotoxic drug to lactose, the cytotoxic drug is maintained in close proximity to the tumor because of the receptors on the tumor which bind the lactose (and therefore the cytotoxic agent bound thereto) to the tumor cells. By using a conjugate of lactose with a cytotoxic agent, one dose is generally sufficient to destroy the receptor sites on the tumor and prevents metastasis of the tumor while treating the tumor.
Patent CA-2209195-A1 (CA)
Inventor: ROUTHIER RENE
IPC: E06B9/52
Filed: 1997-08-06
Abstract: Devant un moustiquaire endommagé, nous avons peu de choix si on veut le réparer. Vous trouverez sous-pli une invention qui remédie à cette situation. Elle consiste à appliquer deux composantes complémentaires décoratives soit une de chaque côté du moustiquaire avec du Velcro ou de la colle. Ce procédé a l'avantage de cacher la technique de fusion des deux parties complémentaires décoratives, augmente considérablement l'adhérence et a l'avantage de pouvoir être décoratif et peu coûteux.
Patent CA-2209430-A1 (CA)
Title: Cosmetic and/or dermatological acid composition containing one cross-linked poly(2-acrylamido 2-methylpropane sulfonic acid) polymer neutralized to at least 90%
Inventor: HANSENNE ISABELLE
IPC: A61Q19/10
Filed: 1997-06-27
Abstract: Cosmetic and dermatological compositions containing in an aqueous acid medium at least one 90% or more neutralised, crosslinked poly(2-acrylamido-2-methyl propane sulphonic acid), are new.
Patent CA-2209988-A1 (CA)
Title: Affinity selection of ligands by mass spectroscopy
Inventor: HUEBNER VERENA D
IPC: G01N33/538
Filed: 1996-01-16
Abstract: Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this selection at two or more different ratios of compound to target.
Patent CA-2211363-A1 (CA)
Title: Improved pea harvester
Inventor: MCDONALD JAMES MITCHAEL
IPC: A01D57/03
Filed: 1997-07-24
Abstract: The present invention provides an improved harvester particularly of the type for harvesting peas. The harvester employees an improved technique of harvesting peas and similar crops. Instead of attempting to break the stem of the plant by pulling it away from the ground, which is the usual technique employed by current harvesters, the individual plants are drawn upwards then cut with a cutting bar or like device. This technique may be utilized by harvesters built specifically for this type of harvesting, or by existing harvesters after modifying the reel of the harvester. The improved harvester comprises a cutting bar, a rotary reel, a plurality of tines arranged in a plurality of rows on the reel, cam tracks and cam followers for raising the plurality of tines relative to crops in front of the cutting bar, as the reel rotates, thereby lifting the crops upwards to a position for cutting.
Patent CA-2213198-A1 (CA)
Title: Gene therapy by anti-tgf-b agents
Inventor: BORDER WAYNE A
IPC: A61K48/00
Filed: 1996-02-14
Abstract: The present invention provides methods for reducing a pathology in a subject characterized by a deleterious accumulation of TGF-.beta.-induced extracellular matrix in a tissue by introducing a nucleic acid encoding a TGF .beta.-specific inhibitory agent or active fragment thereof into a cell in the subject. In one embodiment, the nucleic acid encoding the TGF-.beta.-specific inhibitory agent is introduced into a cell in vivo by injection, for example, in skeletal muscle. In another embodiment, the nucleic acid encoding the TGF .beta.-specific inhibitory agent is transfected into a cell ex vivo to obtain a cell expressing the agent, and the cell is then administered into the subject to be treated. TGF-.beta.-specific inhibitory agents of the present invention include, but are not limited to, members of the decorin family of proteoglycans such as decorin, biglycan, fibromodulin and lumican or an antibody specific for TGF-.beta.. Pathologies that can be reduced by the present invention include various fibrotic diseases and conditions.
Patent CA-2216805-A1 (CA)
Title: Control of pod dehiscence
Inventor: COUPE SIMON ALLAN
IPC: C12N15/82
Filed: 1996-03-29
Abstract: The invention relates to the use of nucleic acid sequences coding for polygalacturonase in the control of dehiscence in plants. Plants transformed with such nucleic acid sequences are also disclosed.
Patent CA-2222583-A1 (CA)
Title: Method and apparatus for modifying existing relational database schemas to reflect changes made in a corresponding object model
Inventor: KAWAI KENJI
IPC: G06F12/00
Filed: 1996-06-03
Abstract: An object model comprises one or more semantic objects that represent items about which data is stored in a relational database in a computer system. Each semantic object has one or more components that define the data stored for each item. The object model is mapped into a current relational database schema. As a user makes changes to the model the computer system generates a proposed relational database schema, and the differences between the current relational database schema and the proposed relational database schema are determined. The relational database is modified to reflect changes made in the corresponding object model based upon the differences between the current and proposed relational database schemas.
Patent CA-2224398-A1 (CA)
Title: Overbased pvc stabilizer
Inventor: BAE KOOK JIN
IPC: C08L27/06
Filed: 1996-06-19
Abstract: PVC stabilizers containing an overbased mixture of salts, such as magnesium and zinc salts, of unsubstituted and/or alkyl-substituted benzoic acid and optionally one or more fatty aliphatic acids, which contain a carbonate and/or silicate stabilizer, and which preferably also contain one or more polyols containing 2 to 10 hydroxyl groups, exhibit significant and unexpected reduction in the tendency to volatilize and form "fog" upon exposure of the formulation to moderately elevated temperatures, without loss of other desirable stabilization properties.
Patent CA-2226131-A1 (CA)
Inventor: HILL FRANK
IPC: A61F2/06
Filed: 1998-01-02
Abstract: Disclosed is a water-insoluble polymer which promotes cell proliferation, is produced by a radical copolymerization and is composed of: (I) repeating units of at least one aliphatically unsaturated monomer containing a carboxylate group; (II) repeating units of at least one aliphatically unsaturated monomer containing a sulfonate group; and (III) repeating units of at least one aliphatically unsaturated monomer other than the components (I) or (II).      The polymer is useful for producing an article, especially a medical article such as an artificial blood vessel.
Patent CA-2226923-A1 (CA)
Title: Power management system for downhole control system in a well and method of using same
Inventor: TUBEL PAULO S
IPC: E21B47/01
Filed: 1998-01-14
Abstract: A downhole power management technique for a downhole well control system maximizes the number of downhole devices which require electrical power. In accordance with this technique, downhole devices which require power and are addressable will be at a low power consumption state (e.g., sleep or dormant mode). When requested by a downhole or surface controller, the downhole device will turn itself on to an active mode and perform its intended function or task (such as transmitting data, acquiring data, actuating a tool or the like). Preferably, only one downhole device is in its active mode at any one time. As a result of this power management technique, the power requirement downhole will be relatively low and substantially constant regardless of the number of downhole devices requiring power.
Patent CA-2230845-A1 (CA)
Title: Double overhead camshaft alignment tool
Inventor: LEARNED KERRY D
IPC: F02F1/38
Filed: 1998-02-27
Abstract: A camshaft alignment tool and method uses a main body having at least three projections to engage cogs on cog wheel driven double overhead camshafts. The tool is used to maintain the cog wheels in a fixed relationship with respect to one another during replacement of a cooperatively toothed timing belt. Use of the tool enables a single technician to change the timing belt on a high performance internal combustion engine employing double overhead camshafts even if the cam surfaces are aggressive and the valve return springs employ large spring constants.
Patent CA-2230896-A1 (CA)
Title: Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
Inventor: GAYO LEAH M
IPC: C07D239/42
Filed: 1996-08-30
Abstract: Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immuno-inflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine-containing compounds and, in one embodiment, are esters of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.
Patent CA-2235930-A1 (CA)
Title: Air bag tear seam and method of manufacture
Inventor: GALLAGHER MICHAEL J
IPC: B60R21/2165
Filed: 1996-11-08
Abstract: An air bag cover (14) for use in a supplement inflatable restraint system includes an air bag cover skin made of a polymeric material. The cover skin includes a weakened tear seam region (16) for guiding the tearing of the air bag cover skin in response to air bag inflation. The tear seam region is weakened by photodegradation, i.e., selective exposure to ultraviolet light (20) which breaks polymer bonds within the polymeric material of the tear seam region. Photodegradation reduces the tensile strength and/or the percent elongation (measured at break) of the tear seam region (16) compared to the rest of the air bag cover skin (24).
Patent CA-2242568-A1 (CA)
IPC: C07D403/04
Filed: 1997-01-10
Abstract: L'invention concerne de nouveaux composés imidazoles 1,4,5-substitués ainsi que des compositions destinées à être utilisées en thérapie.
Patent CA-2242962-A1 (CA)
Title: Dough hook and a food mixer
Inventor: XIE MARK MINGJUN
IPC: A47J43/044
Filed: 1997-09-30
Abstract: A dough hook (50) for a planetary mixer (10) which comprises a shaft portion (52) for attaching said hook (50) to a mixer head (30) and a hook portion having a plurality of points located on a common edge of said shaft.
Patent CA-2243586-A1 (CA)
Title: Composition filmogene epaissie
Inventor: RAMIN ROLAND
IPC: A61K8/00
Filed: 1998-08-27
Abstract: L'invention se rapporte à une composition filmogène épaissie comprenant un polymère filmogène et comme épaississant un alkyléther de polysaccharide formé d e motifs comportant au moins deux cycles osidiques différents, chaque motif comportant au moins un groupe hydroxyle substitué par une chaîne alkyle hydrocar bonée saturée. L'alkyléther de polysaccharide a de préférence un poids moléculaire supérieur à 200 000 et est notamment un alkyléther de gomme de guar ayant un degré de substitution d'environ 2 à 3, en particulier 2,5. La composition obtenue peut être notamment utilisée dans les domaines cosmétique des matières kératiniques et est destinée plus specialement au traitement et au soin des ongles.
Patent CA-2247391-A1 (CA)
Inventor: SCHMIDT JONATHAN M
IPC: G16B20/50
Filed: 1996-03-22
Abstract: The present invention relates to computational methods for designing chemical structures sharing common useful, functional properties based on specific combinations of steric configuration and binding affinity. More particularly the present invention provides a method for producing computer-simulated receptors which functionally mimic biological receptors. The simulated receptors are designed to exhibit optimized selective affinity for known target molecules. Chemical structures are then generated and evolved to exhibit selective affinity for the simulated receptors.
Patent CA-2248157-A1 (CA)
Inventor: GEBHARDT JOACHIM
IPC: C07C205/06
Filed: 1997-03-06
Abstract: The invention concerns a process for preparing nitrobiphenylene of formula (I) wherein m stands for 1 or 2, R means halogen, R' or OR', R' being a C-organic group which can carry groups which are inert in the reaction conditions, n stands for 0, 1, 2 or 3 and, if n is 2 or 3, the R groups can also be different. According to the invention, a chloronitrobenzene of formula (II) is reacted in the presence of a palladium catalyst and a base in a solvent with a phenyl boric acid (IIIa), one of its alkyl esters of formula (IIIb), R' meaning C~-C6 alkyl, or one of its anhydrides. The compounds (I) are suitable as initial products for biphenylamines which are in turn intermediate products for fungicidal plant-growth substances.
Patent CA-2248407-A1 (CA)
Title: Thermally stable aminosulfur trifluorides
Inventor: PESARESI RENO JOSEPH JR
IPC: C07D265/36
Filed: 1998-09-22
Abstract: The present invention relates to an aminosulfur trifluoride having a structure with one or more: (See Formula I) wherein m = 1-5 and R1 and R2 are: (1) when m = 1, individually aryl or meta- or para-substituted aryl radicals in which the meta- or para-substitution is selected from the group consisting of normal and branched C1-10 alkyl, trifluoromethyl, alkoxy, aryl C6-10, nitro, sulfonic ester, N,N-dialkylamino and halogens; or (2) when m = 1, individually aryl radicals which are fused or linked to one another; or (3) when m = 1, one of R1 and R2 is an aryl radical and the other is an at least 5 membered saturated cyclic hydrocarbon radical having zero to three heteroatoms selected from the group consisting of oxygen, nitrogen and mixtures thereof; or (4) when m = 1, one of R1 and R2 is an aryl radical and the other is an at least 5 membered saturated cyclic hydrocarbon radical having zero to three heteroatoms selected from the group consisting of oxygen, nitrogen and mixtures thereof wherein the cyclic hydrocarbon radical is fused to the aryl radical; or (5) when m = 1, together a cyclic ring having 2 to 10 carbon ring members and 1 heteroatom selected from the group consisting of oxygen, nitrogen and alkylated nitrogen wherein the ring has 1 to 2 alkoxyalkyl functionalities; or (6) when m = 1, together an unsaturated cyclic ring having 2 to 4 carbon ring members and one to three heteroatoms selected from the group consisting of oxygen, nitrogen, protonated nitrogen and alkylated nitrogen wherein the ring has one to three groups selected from hydrogen, normal and branched C1-10 alkyl, haloalkyl, alkoxy, aryl, halogen, cyano, nitro and amino or (7) when m = 1, individually alkoxyalkyl radicals; or (8) when m = 1, one of R1 and R2 is alkoxyalkyl and the other is selected from the group consisting of alkyl and aryl radicals or (9) when m = 2-5, R1 is a single phenyl radical linked to each -NSF3 radical and R2 is an aryl radical having C6 to C10; or (10) when m = 2-5, R1 and R2 are individually divalent aryl radicals of C6 to C10 linked to adjacent -NSF3 radicals except R1 and R2 are monovalent aryl radicals having C6 to C10 where R1 and R2 are linked only to one -NSF3 radical.
Patent CA-2248411-A1 (CA)
Title: Fastener assembly with lateral end extension
Inventor: ERNST RICHARD J
IPC: F16B15/08
Filed: 1998-09-22
Abstract: The present invention is a fastener assembly including a row of fasteners maintained in position by a carrier. The carrier includes a plurality of adjacent sleeves, each of which includes an upper breakable portion, a middle wall portion and a lower breakable portion. When a fastener is driven into a work piece, the upper and middle portions of the fastener sleeve break away and the lower portion breaks into fragments, so that no residual sleeve parts remain with the fastener. This is accomplished by forming the carrier from a mixture of a stiff polyolefin material and a particulate filler to impart the necessary brittleness to the carrier sleeves. The plurality of carrier sleeves include two end sleeves. At least one end sleeve includes a lateral end extension in the lower breakable portion which helps to balance and stabilize the fastener assembly in the shear block and magazine holder of a fastener driving tool.
Patent CA-2249603-A1 (CA)
Title: Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ant)agonists of 5-ht1a- and/or 5-ht1d receptors
Inventor: HOWARD HARRY R
IPC: C07D217/24
Filed: 1997-02-03
Abstract: A compound of formula (I) wherein R1 is a group of formula G1, G2, G3, G4 or G5; R2 is hydrogen, (C1-C4)alkyl, phenyl or naphthyl, wherein said phenyl or naphthyl may optionally be substituted with one or more substituents, preferably from zero to three substituents, independently selected from chloro, fluoro, bromo, iodo, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl, cyano and SOg(C1-C6)alkyl wherein g is zero, one or two; R3 is (CH2)mB, wherein m is zero, one, two or three and B is hydrogen, phenyl, naphthyl or a 5- or 6-membered heteroaryl group containing from one to four hetero atoms in the ring (e.g., furyl, thienyl, pyridyl, pyrimidyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, etc.), and wherein each of the foregoing aryl and heteroaryl groups may optionally be substituted with one or more substituents, preferably from zero to three substituents, independently selected from chloro, fluoro, bromo, iodo, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl, cyano hydroxy, COOH  and SOg(C1-C6)alkyl, wherein g is zero, one or two; Z is CR4R5, wherein R4 and R5 are independently selected from hydrogen, (C1-C6)alkyl and trifluoromethyl;  or Z may be one of the aryl or heteroaryl groups referred to in the definition of B above and wherein two adjacent ring members of Z are also members of ring A; X is hydrogen, chloro, fluoro, bromo, iodo, cyano, (C1-C6)alkyl, hydroxy, trifluoromethyl, (C1-C6)alkoxy, -SOg(C1-C6)alkyl, wherein g is zero one or two, CO2R10 or CONR11R12; each of R10, R11 and R12 is selected, independently, from the radicals set forth in the definition of R2; or R11 and R12, together with the nitrogen to which they are attached, form a 5- to 7-membered ring that may contain from zero to four heteroatoms selected from nitrogen, sulfur and oxygen; n is one, two, three or four; and the broken line indicates an optional double bond; and R6, R7, R8, R9, R13, E, p and x are defined as in the specification; with the proviso that n must be one when Z is a heteroaryl group; or a pharmaceutically acceptable salt thereof. These compounds are selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors and thus are useful as psychotherapeutic agents.
Patent CA-2252112-A1 (CA)
Inventor: MILLER CHARLES G
IPC: E02B17/00
Filed: 1997-04-18
Abstract: A method for preventing marine biofouling on the surface of a structure exposed to an aquatic environment is provided. The method comprises disposing an impermeable laminated heater element on the surfaces of the structure which is to be submerged into water and heating the element at prescribed intervals and to prescribed temperatures effective to kill or prevent settlement of larvae onto said surface.
Patent CA-2252373-A1 (CA)
Title: Improved binding assembly for a snowboard
Inventor: MANSURE BRIAN A
IPC: A63C10/04
Filed: 1997-05-16
Abstract: A binding assembly (12) for use on a sport board (16) which includes a binding plate (20) which may be attached to the boot (14) of a rider and a mounting plate (30) which is attached to the board. First and second hinge assemblies (50, 54) pivotally attach the mounting plate to the binding plate. The first hinge assembly includes two hinge arms (60, 80), each being pivotally mounted at a first end to the mounting plate about a first axis of rotation (52) and pivotally mounted at a second end to the binding plate about a second axis of rotation (56). The second hinge assembly also includes two hinge arms (72, 86), each being pivotally mounted at a first end to the binding plate about the first axis of rotation (52) and pivotally mounted at a second end to the mounting plate about the second axis of rotation (56). The binding assembly permits the binding plate to selectively pivot between a home position and about each one of the first and second axes of rotations.
Patent CA-2257779-A1 (CA)
Inventor: TORT JOSE PEDRO
IPC: A61F5/455
Filed: 1999-01-07
Abstract: The present Utility Model is a device which main purpose is to provide women means that allow them to urinate standing up. For such end, it consists of a small tube 17 cm long, said tube having a biased cut end, where it has a ring made of an antiallergenic material, all of which provide women something like the artificial prolongation of the urethra.
Patent CA-2258371-A1 (CA)
Title: Stable compositions for removing stains from fabrics and carpets and inhibiting the resoiling of same
Inventor: TRIPATHI UMA
IPC: C11D3/37
Filed: 1999-01-05
Abstract: There is provided an aqueous composition for cleaning fabrics and carpets and inhibiting the resoiling of fabric and carpets. The composition includes a water miscible organic solvent, a peroxygen compound, a surfactant, a polymeric or copolymeric soil resist, and a fluorinated hydrocarbon soil resist. The solvent is selected from isopropanol, propylene glycol methyl ether, dipropylene glycol methyl ether, or mixtures of two or more thereof. Compositions formed with these solvents and both soil resists are particularly stable and non-turbid.