Patent TW-200510346-A (TW)
Title: Benzotriazapinone salts and methods for using same
Inventor: ABDEL-MAGID AHMED F
IPC: C07D401/04
Filed: 2004-05-11
Abstract: This invention relates to pharmaceutically acceptable salts of compounds of formula (I), wherein: W is N or N+ -O-; R1 and R5 are independently H, C1 to C6 alkyl, (C1 to C6 alkyl)oxy, thio, (C1 to C6 alkyl)thio, carboxy, carboxy(C1 to C6 alkyl), formyl, (C1 to C6 alkyl)carbonyl, (C1 to C6 alkyl)oxycrabonyl, (C1 to C6 alkyl)carbonyloxy, nitro, trihalomethyl, hydroxy, hydroxy(CC to C6 alkyl), amino, (C1 to C6 alkyl)amino, di(C1 to C6 alkyl)amino, aminocarbonyl, halo, halo(C1 to C6 alkyl), aminosulfonyl, (C1 to C6 alkyl)sulfonylamino, (C1 to C6 alkyl)aminocarbonyl, di(C1 to C6 alkyl)ammocarbonyl, [N-Z](C1 to C6 allcyDearbonylamino, formyloxy, formamido, (C1 to C6 alkyl)aminosulfonyl, di(C1 to C6 alkyl)aminosulfonyl, [N-Z](C1 to C6 alkyl)sulfonylamino or cyano; or R1 and R5 together fonn a methylenedioxy group; R2 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms. R3 is -(CR11R12)m-X-(CR13R14)p-R9; mis 0, 1, 2, 3 or 4; pis 0, 1 or 2; X is a bond, -CR15=CR16-, -C≡C-, C(O)NH, NHC(O), C(O)Nme, NMeC(O), C(O)O, NHC(O)NH, NHC(O)O, OC(O)NH, NH, O, CO, SO2, SO2NH, C(O)NHNH, R9 is H; C1 to C6 alkyl; or phenyl, naphthyl, pyridyl, benzimidazolyl, indazolyl, quinolinyl, isoqumolinyl, indolinyl, isoindolinyl, indolyl or isoindolyl all optionally substituted with 1, 2 or 3 groups independently selected from -L-Q wherein: L is a bond, or a group of the formula -(CR17R18)v-Y-(CR17R18)w, wherein v and w are independently 0, 1,2 or 3, and Y is a bond, -CR15=CR16-, phenyl, furanyl, thiophenyl, pyrrolyl, thiazolyl,imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, isoxazolonyl, piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, isothiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyridyl or pyridazyl; and Q is H, (C1 to C6 alkyl)oxy, [N-Z](C1 to C6 alkyl)oxy(C1 to C6 alkyl)amino, thio, (C1 to C6 alkyl)thio, carboxy(C1 to C6 alkyl)fhio, carboxy, carboxy(C1 to C6 alkyl), carboxy(C1 to C6 alkenyl), [N-Z]carboxy(C1 to C6 alkyl)amino, carboxy(C1 to C6 alkyl)oxy, formyl, (C1 to C6 allcyl)carbonyl, (C1 to C6 alkyl)oxycarbonyl, (C1 to C6 alkyl)carbonyloxy, nitro, trihalomethyl, hydroxy, amino, [N-Z](C1 to C6 alkyl)amino, aminocarbonyl, (C1 to C6 alkyl)aminocarbonyl, di(C1 to C6 alkyl)aminocarbonyl, [N-Z](C1 to C6 alkyl)carbonylamino, C5 to C8 cycloalkyl, [N-Z](C1 to C6 alkyl)carbonyl(C1 to C6 alkyl)amino, halo, halo(C1 to C6 alkyl), sulfamoyl, [N-Z](C1 to C6 alkyl)sulfonylamino, (C1 to C6 alkyl)sulfonylammocarbonyl, carboxy(C1 to C6 alkyl)sulfonyl, carboxy(C1 to C6 alkyl)sulfinyl, tetrazolyl, [N-Z]tetrazolylamino, cyano, amidino, amidinothio, SO3H, formyloxy, formamido, C3 to C8 cycloalkyl, (C1 to C6 alkyl)sulphamoyl, di(C1 to C6 alkyl)sulphamoyl, (C1 to C6 alkyl)carbonylaminosulfonyl, 5-oxo-2,5-dihydro[1,2,4]oxadiazolyl, carboxy(C1 to C6 alkyl)carbonylamino, tetrazolyl(C1 to C6 alkyl)thio, [N-Z]tetrazolyl(C1 to C6 alkyl)amino, 5-oxo-2,5-dihydro[1,2,4]thiadia2olyl, 5-oxo-1,2-dihydro[1,2,4]tria2olyl, [N-Z](C1 to C6 alkyl)amino(C1 to C6 alkyl)amino, or a group of the formula, , wherein P is O, S or NR19; Z is H, C1 to C6 alkyl, t-butoxycarbonyl, acetyl, benzoyl or benzyl; R4 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms; and R11, R12 R13, R14, R15, R16, R17, R18 and R19 are independently H or C1 to C3 alkyl. Such salts are useful, for example, for the treatment ofgastrin related disorders.