Patent SG-11201901525X-A (SG)
Title: Muscarinic m1 receptor positive allosteric modulators
Inventor: NIROGI RAMAKRISHNA
IPC: C07D498/04
Filed: 2017-08-31
Abstract: International Patent Classification: CO7D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/436 (2006.01) C07D 491/04 (2006.01) A61K 31/4353 (2006.01) C07D 498/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) REVISED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIPO I PCT 11111111111101101010111110111101011 110E 0111001110101E0M1110# (10) International Publication Number WO 2018/042362 A9 PCT/IB2017/055238 (22) International Filing Date: 31 August 2017 (31.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201641030062 02 September 2016 (02.09.2016) IN 201741013343 13 April 2017 (13.04.2017) IN (71) Applicant: SUVEN LIFE SCIENCES LIMITED [IN/IN]; Serene Chambers, Road - 5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500 034 (IN). (72) Inventors: NIROGI, Ramakrishna; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). SHINDE, Anil Karbhari; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). MOHAMMED, Abdul Rasheed; Suven Life Sciences Limited, Serene Chambers, Road-5, Av- enue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). BADANGE, Rajesh Kumar; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). JAYARAJAN, Pradeep; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad, Telan- gana 500034 (IN). BHYRAPUNENI, Gopinadh; Suven Life Sciences Limited, Serene Chambers, Road-5, Av- enue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). JASTI, Venkateswarlu; Suven Life Sciences Limit- ed, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). (74) Agent: KAPOOR, Divya et al.; Central Square, Suite-328, Plaza III, 20 Manoharlal Khurana Marg, Bara Hindu Rao (off Rani Jhansi Road), Delhi 110006 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the revised international search report: 03 May 2018 (03.05.2018) (54) Title: MUSCARINIC Ml RECEPTOR POSITIVE ALLOSTERIC MODULATORS W O 20 18/04236 2 A9 (I) (57) : The present invention relates to compounds of formu- la (I), or their isotopic forms, stereoisomers, tautomers or pharmaceu- tically acceptable salt (s) thereof as muscarinic Ml receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound for- mula (I). [Continued on next page] WO 2018/042362 A9 MIDEDIMOM0101011MOIER1001111111111111111101111111011111110B10# (15) Information about Correction: see Notice of 03 May 2018 (03.05.2018)