baber/WOPTO huggingface dataset:
Patent CR-20110264-A (CR)
Title: Pirazolilaminopiridinas como inhibidores de fak
Inventor: JERRY LEROY ADAMS
IPC: A61K31/535
Filed: 2011-05-17
Abstract: La presente invención se refiere a un compuesto de fórmula (I): o una sal farmacéuticamente aceptable del mismo, en la que R1, R2, R3, R11, R12, R13, Q, Z y p son como se han descrito en la presente memoria. Los compuestos de la presente invención son útiles para el tratamiento de cánceres.
Patent CR-20120186-A (CR)
Title: Análogos de carba-nucleósidos sustituidos con 2'-fluoro para tratamiento antiviral
Inventor: CHO AESOP
IPC: C07D487/04
Filed: 2012-04-17
Abstract: Se proporcionan nucleosidos fosfatos de neuclosidos de pirrolo (1,2-f) (1,2,4) triazinilo, imidazo (1,5-f) (1,2,4) triazolo (4,3-f) (1,2,4) triazinilo y profarmacos de los mismos, donde la posicion 2 del glucido nucleosidico se sustituye con sustituyentes halogeno y carbono.
Patent CR-20160357-A (CR)
Title: Aro de soporte para instrumentos de escritura en superficies verticales
Inventor: HERNÁNDEZ VÁZQUEZ ERNESTO
IPC: B43L27/04
Filed: 2016-08-09
Abstract: La presente invención se refiere a medios de soporte de instrumentos de escritura en superficies verticales como pizarrones, rota folios u hojas de control, dichos medios de soporte comprenden un aro donde se inserta el intrumento de escritura u medios de adhesión a la superficie vertical.
Patent CR-20170046-A (CR)
Title: Recipiente metalico para horno de microondas
Inventor: ALVAREZ-ZAVALA ALBERTO
IPC: B65D81/34
Filed: 2014-07-15
Abstract: La presente invención se refiere a un recipiente metálico para horno de microondas de la presente invención comprende un cuerpo moldeado de manera integral que a su vez comprende: una base que le permite al recipiente apoyarse en una superficie; y, una pared dividida en por lo menos una sección de pared que se extiende desde el perímetro de la base para contener productos, con una altura máxima del 40 por ciento de la longitud de onda de la radiación emitida por el horno de microondas; en donde todos los ángulos que se forman por la parte interna del recipiente en la intersección de planos entre las secciones, son mayores a 90º (p/2 radianes) y tales intersecciones tienen forma de chaflán con sección de arco con un radio de por lo menos 0.5 mm, donde los extremos del arco están en los puntos en los que los planos que se intersectan para formar los ángulos, son tangentes al arco
Patent CR-20230207-A (CR)
Title: Conjugado anticuerpo-fármaco y aplicación del mismo
Inventor: LI HU
IPC: C07K16/30
Filed: 2021-10-19
Abstract: La presente invención se relaciona con un conjugado de anticuerpo-fármaco y con una aplicación del mismo, y proporciona específicamente el conjugado de anticuerpo y fármaco, una sal farmacéuticamente aceptable y un solvato del mismo, o un solvato de la sal. El conjugado anticuerpo-fármaco tiene la estructura representada por la fórmula I, en donde Ab es un anticuerpo anti-Claudina 18.2. El conjugado anticuerpo-fármaco de la presente invención tiene una buena actividad de inhibición del crecimiento de células tumorales <em>in vivo</em> e <em>in vitro</em>, baja toxicidad y buenas perspectivas de aplicación. Ab-(L-D)<sub>p</sub> Fórmula I
Patent EC-SP045492-A (EC)
Title: Regímenes de tratamiento con bazedoxifeno
Inventor: KOMM BARRY S
IPC: A61P25/28
Filed: 2004-12-13
Abstract: Esta invención está relacionada con los regímenes de dosificación prolongada para el modulador selectivo de receptores estrogénicos, el bazedoxefino (1-[4-(2-azepan-1-iletoxi)-bencil]-2-(4-hidroxifenil)-3-metil-1H-indol-5-ol).
Patent EC-SP055687-A (EC)
Title: Ácidos nucleicos inmunoestimuladores
Inventor: KRIEG ARTHUR M
IPC: C12Q1/68
Filed: 2005-03-18
Abstract: La invención se relaciona con una clase de oligonucleótidos inmunoestimuladores CpG blandos o semiblandos útiles en la estimulación de la respuesta inmune.
Patent EC-SP982712-A (EC)
Title: Nuevo procedimiento para preparar ciertos derivados de tiazolidindiona sustituida
Inventor: GILES ROBERT GORDON
IPC: C07D277/34
Filed: 1998-10-27
Abstract: Un procedimiento para preparar un compuesto de fórmula (I): (gráfico),o una de sus formas tautómeras o una de sus sales farmacéuticamente aceptables o uno de sus solvatos farmacéuticamente aceptables, en la que: A1 representa representa un grupo heterociclilo aromático sustituido o no sustituido; R1 representa un átomo de hidrógeno, un grupo alquilo, un grupo acilo, un grupo aralquilo, en el que el resto arilo puede estar sustituido o no sustituido, o un grupo arilo sustituido o no sustituido; A2 representa un anillo de benceno que tiene en total hasta cinco sustituyentes; y n representa un número entero en el intervalo de 2 a 6, comprendiendo dicho procedimiento reducir catalíticamente un compuesto de fórmula (II) (gráfico) en la que A1, R1 A2 y n son como se han definido con relación a la fórmula (I), caracterizado porque la reacción de reducción se realiza usando una presión de hidrógeno superior a 1,4 Kg/cm2 (20psi); y a continuación, si se requiere, formar una sal farmacéuticamente aceptable y/o un solvato farmacéuticamente aceptable del compuesto de fórmula (I).
Patent FR-1602473-A (FR)
Title: Thermo-forming coupler for diazotype - material
IPC: C07D277/64
Filed: 1968-12-26
Granted: 1970-11-30
Abstract: Coupler formed on radiation with heat or UV - rays acting with diazonium cpd is quaternary heterocyclic nitrogen cpd and/or hydrazone such as 1-hydroxyethyl-2,3,3-trimethyl-3-H-indolinium bromide or N'-(2,3-dimethyl-2-propanone)-N-hydroxyethylphenyl hydrazone; alternatively a methylene indoline such as 1,3,3-trimethyl-2-methylene indoline positioned in separate layer is transferred by heat to image layer. Premature coupling may be avoided by use of meltable inter-layer of polyvinylacetate, colophonium or ester rubber.
Patent GB-1050186-A (GB)
IPC: H03H7/01
Abstract: 1,050,186. Band-pass filters. U. GOLTERMANN, [trading as WANDER U. GOLTERMANN]. May 4, 1965 [May 26, 1964], No. 18789/65. Heading H3U. In an arrangement where a generator having an internal resistance Ri feeds a load R L  through a number of band-pass filters BP-1 . . . BP-n having different mid-band frequencies and different degrees of attenuation, in order to equalize the degrees of attenuation and also to match each filter to the resistance Ri, a transformer T r <SP>1</SP>, T r <SP>2</SP>, T r <SP>n</SP> having its primary shunted by a resistor Rp<SP>1</SP>, Rp<SP>2</SP> or Rp<SP>n</SP> is connected to the input or output of each filter, the transformer ratios and the values of the resistors being determined by formulae stated in the Specification.
Patent GB-1051661-A (GB)
IPC: B41L1/24
Abstract: 1,051,661. Bookbinding. B. CALVERT. Feb. 5, 1964 [Feb. 11, 1963; June 11, 1963], Nos. 5479/63 and 23294/63. Heading B6A. In a method of forming sets of two or more sheets of paper, the sets are arranged in a stack and an adhesive applied to one edge of the stack, the absorbency of the sheets being arranged so that adhesive is absorbed into the edges of the sheets which are to be joined together but not sufficiently into the outer surfaces of the outer sheets of each set to an extent that the sets cannot be easily separated. The outer sheets comprise hard sized sheets or have non-absorbent surfaces on the outer or both sides. In a modification, all the sheets of each set are of the same type and density, the " non-absorbent " sheets being obtained by arranging the grain direction parallel to the gummed edge and the " absorbent " sheets obtained by arranging the grain direction normal to the gummed edge. The sheets may carry water marks indicating the grain direction.
Patent GB-1051808-A (GB)
IPC: H01L21/205
Abstract: 1,051,808. Silicon; germanium. SIEMENS & HALSKE A.G. June 9, 1964 [June 10, 1963], No. 23752/04. Heading C1A. [Also in Divisions C7 and H1] Monocrystalline. high-ohmic, p-conductive layers of a semi-conductor material, e.g. silicon, germanium are prepared by transferring P- doped semi-conductor material by means of a reaction gas by a transport reaction from the surface of the first heated plate of P-doped semi-conductor material on to the adjacent surface of a monocrystalline carrier plate of the semi-conductor arranged parallel to and spaced from said first plate to provide a reaction zone between the two plates through which the transport reaction takes place, the two plates being spaced apart by spacers of said semiconductor material, in which transport reaction semi-conductor material at the surface of the plate is converted by the reaction gas into a gaseous compound, which compound decomposes at the cooler adjacent surface of the carrier plate to deposit semi-conductor material, and the distance between said plates being such that only material from the first plate is transferred to the carrier plate and entry of impurities from the free gas space outside the reaction zone is prevented by convection currents inside the reaction zone. A monocrystalline plate 3 of high-ohmic, P-conductive silicon, preferably doped with boron, is arranged on a heated base 1 of inert material provided with a coating 2 of the semi-conductor material. A monocrystalline carrier plate 4 of the same or different conductivity, P- or N-conductive, is arranged with a distance of say 200 microns between adjacent surfaces of the plates. The plates are held apart by spacers 5 formed by fragments of high ohmic silicon plate and resting on plate 3 at three points. Plates 3 and 4 can be etched in 40% hydrofluoric acid, afterwards chemically polished, and annealed for 30 minutes at 1250‹ C. in flowing hydrogen. The heated plate 3 may be at 1150‹ C. A mixture of a gaseous silicon compound, in particular SiCl 4 , and hydrogen is used as a reaction gas with a composition say 0À01: 1 mole ratio SiCl 4  to H 2 . The layers are suitable for the manufacture of semi-conductor components, e.g. high frequency and switching transistors, microwave rectifiers.
Patent GB-1052278-A (GB)
IPC: F16C17/22
Abstract: 1,052,278. Bearings. COMMISSARIAT A L'ENERGIE ATOMIQUE. Oct. 10, 1963 [Oct. 11, 1962], No. 39990/63. Heading F2A. A bearing comprises two concentric sleeves 2 and 7 (not shown), one being mounted on a stationary support 1 and the other on a rotatable shaft 6, each sleeve has chamfered ends and is held in position by two similarly chamfered rings 3 and 4 or 8 and 9, clamped by nuts 5 and 10 respectively. The rings 3 and 4 are made of the same material as the support 1 and the rings 8 and 9 the same as the shaft 6. The arrangement ensures that the clearances between the sleeves and their respective rings remain constant during temperature changes.
Patent GB-1053310-A (GB)
IPC: H02G1/08
Abstract: 1,053,310. Pull-through rods. H.V.E. (ELECTRIC) Ltd. April 14, 1965 [Aug. 10, 1964], No. 32415/64. Heading F2N A string for drawing an electric wire through a tube 5 is inserted through a branch 2 of a forked element 1 and pressurized fluid is introduced into a branch 3 of the element to blow the string through the tube.
Patent GB-1225530-A (GB)
IPC: B26D1/00
Filed: 1968-11-19
Abstract: 1,225,530. Splitting apparatus. HARRISON & JONES Ltd. 22 Aug., 1969 [19 Nov., 1968], No. 54740/68. Heading B4B. [Also in Division B8] Apparatus for splitting blocks of plastics material, e.g. polyurethane flexible foam, comprises a continuous conveyer system moving in a horizontal plane beneath a fixed cutting head. A first conveyer 2 passes beneath a fixed cutting head 4 and a second conveyer 8, travelling in the opposite direction to the conveyer 2, passes below a fixed cutting head 10. Conical rollers 6 and 12 are located at the ends of the conveyer in order to turn the material from one conveyer to the other. In order to assist in turning the material a series of rollers are placed at successively reducing angles to the vertical plane thereby turning the material from the horizontal to the vertical as it passes round the corners. In a modification four conveyers set at ninety degrees may be used in co-operation with cutting heads set at different heights.
Patent GB-1226765-A (GB)
IPC: G01N23/16
Filed: 1968-05-08
Abstract: 1,226,765. Radiation type coating monitor. RFT MESSELEKTRONIK DRESDEN VEB. May 8, 1968, No. 21804/68. Heading G1A. [Also in Divisions G4 and H3] In apparatus for measuring thickness (or surface mass) an application of a coating 4 to a carrier web 2 (Fig. 1) isotopic measuring instruments 1, 5 determine the parameters for the uncoated and the coated web traversing coating machine 4; the coating thickness being determined by signal subtraction at 6. The signals from 1 are retarded in delay memory 7 for the time of web transit between 1 and 5 by clock generator 8 synchronized with the coating machine. Clock pulses (Fig.2) are fed to series counters 9, 10 comprising ring flip-flops cyclically operating transistor switches 11 to 13 and 14 to 16 over decoding circuits and a switching amplifier (not shown) whereby a matrix of relays 17 to 25 are cyclically and successively excited, which over respective contacts 26 to 34 connect capacitors 35 to 43 successively across the input signals. A switch 44 enables a second matrix of relays 45 to 53 to be cyclically selected, so that when switch 14 is operated and switch 44 is in its left hand position, relays 17+45, 18+46, 19+47 etc or 17+51, 18+52, 19+53 etc or 17+44, 18+49, 19+50 etc are similarly excitable simultaneously and sequentially for the remaining positions of 44. The relays 45 to 53 operate interrogation contacts 54 to 62 cyclically and successively across the output. Hence according to the position of switch 44, one capacitor is always connected to the output which was charged from the input at e. g. 6 clock pulse intervals prior to the selection of that switch position. If the matrices employ n lines and m columns the delay time expressed by the number of capacitors between input and interrogation vary according to series 0, n, 2n, ---- (m-1)n, in response to variation of the number of capacitor positions 41. In a modification Fig. 3 (not shown), increasing the number of delay time steps; the co-ordinated lines interconnecting relays 19 to 25 and 45 to 53 are electronic switchably arranged to be cyclically interchangeable; erroneous information during switching being avoided by inserting similarly poled halfwave diodes in series with the lines from switches 14 to 16 to relays 17 to 25, and in shunt between pairs of such lines 41. In a further modification Fig. 4 (not shown) switching is provided by which, for any switch 14 to 16, one of two relay columns may be selected; the switching being operated by impulses of auxiliary switching synchronous with the cyclical interchange switching in the co-ordinated lines inter-connecting relays 19 to 25 and 45 to 53 Fig. 3, (not shown); whereby a cyclically selectable storage capacity of 0, 1, 2, - -- (m-1)n is provided. The switches may be electronic e.g. transistor switches, and the pulse counters may be decades with decoding circuits.
Patent GB-1227086-A (GB)
IPC: C08G59/42
Filed: 1969-07-02
Abstract: 1,227,086. Laminates. SOC. CHIMIQUE DES CHARBONNAGES. 2 July, 1969 [2 July, 1969], No. 33481/69. Heading B5N. [Also in Division C3] Laminates are prepared from glass fabrics and resinous compositions obtaining by heating an epoxy resin with a polycarboxylic acid anhydride in a polar solvent until the mixture is completely dissolved. Reaction is terminated by stopping the heating; the solvent may then be removed and the resin dissolved in a ketone or ester. From 10-150 parts of polar solvent, e.g. dimethylsulphoxide, dimethylformamide, acrylonitrile or acetonitrile, are used per 100 parts by wt. of epoxy resin. Up to 0À5 mol. of anhydride may be used per epoxy group in the resin. Suitable anhydrides are the dianhydrides of benzophenonetetracarboxylic acid and cyclopentanedicarboxylic acid. In an example a 6-sheet laminate is made by pressing for 1¢ hours at 160 C. under 75 kg./sq. cm.
Patent GB-1228466-A (GB)
IPC: H01H3/46
Filed: 1968-05-23
Abstract: 1,228,466. Switch boxes; mechanical switches; retractive switches. INTERNATIONAL STANDARD ELECTRIC CORP. 23 May, 1968 [25 May, 1967], No. 24687/68. Heading H1N. A switch mechanism comprises a frame having a rigid base-member Z, a top member M constrained by side members K, L to move sideways yet parallel to base Z and in the plane passing through base Z, top member M and at least one side member K, the members being connected by flexural pivots A, R, electrical contacts mounted on base Z, means associated with top member M for moving at least one contact when top member M is moved and means for distorting the frame so that top member M moves. Cantilevered contact springs would be mounted in slots B, the middle spring extending through slot N in top M and acting as a lever so that when top M is moved relative to base Z, pivoting about flexible parts A, R, the contacts are actuated. The frame is preferably of thermoplastic material such as an acetal resin but may be of metal with the flexible parts made from suitable elastic material, e.g. spring steel. The contacts may be of any type such as simple cantilevered contact springs, prestressed cantilevered contact springs, reed contacts, contact bars, sliding contacts or pivoting contacts. The top M may be moved through an extension (not shown) of parallel side walls K and L, or by a separate lever X, Fig. 6 (not shown). Stops H and J, Fig. 3 (not shown), limit the movement of the frame. In a second embodiment, Fig. 7 (not shown), the stops are integral with and depend from the top member M and a pre-tensioned spring W is incorporated to close the contacts. In a third embodiment, Fig. 8 (not shown), one side wall L and two pivots A are replaced by springs which may be attached to the top member of the frame or to a detachable actuating plate G driven by the top member of the frame.
Patent GB-1229428-A (GB)
IPC: A61K31/57
Filed: 1968-04-01
Abstract: 1,229,428. 1,2-Methylene-steroids. SCHERING A.G. 1 April, 1968 [31 March, 1967; 11 Jan., 1968], No. 15526/68. Heading C2U. 17 - Hydroxy - 6#,7# - epoxy - 1α,2α - methylene-4-pregnene-3,20-dione and acylates thereof, which are novel compounds, are prepared by reacting 17-acyloxy-6#-(acyloxy or hydroxy)- 7α-(chloro or bromo) -1α,2α-methylene-4-pregnene-3,20-diones with a base in an inert solvent, and, if desired, when the product is a free 17-ol, acylating this. The starting materials are prepared from the corresponding #<SP>6</SP>-steroids; reaction of these with N-bromo- or N-chloro-succinimide and water in the presence of perchloric acid in dioxan gives the 6#-hydroxy-7#-halogeno-steroids, while reaction with the same halogenating agents and a carboxylic acid in tetrahydrofuran saturated with HCl gives the 6#-acyloxy-7α- halogeno-steroids. The novel steroids are stated to have strong gestagenic activity with little anti-androgenic effect and no ovulation inhibiting effect, and they may be made up into pharmaceutical compositions with suitable carriers.
Patent GB-1231108-A (GB)
IPC: G01R15/18
Filed: 1969-03-13
Abstract: 1,231,108. Current transformers. GENERAL ELECTRIC CO. 13 March, 1969 [20 March, 1968], No. 13209/69. Heading H1T. A current transformer 20 for measuring large currents in a conductor 10, undisturbed by stray magnetic fields from adjacent conductors, consists of a non-magnetic non-conducting core 22 wound with a secondary winding 24 having an even number of layers, each wound over the whole core so that both ends of the complete winding are at A.
Patent GB-1231775-A (GB)
IPC: C04B35/03
Filed: 1969-04-11
Abstract: 1,231,775. Fused cast refractories. GENERAL REFRACTORIES Ltd. 11 April, 1969 [11 April, 1968], No. 18692/69. Heading C1J. Refractory brick for lining electric furnaces and oxygen blast converters is made by casting a melt containing CaO, MgO and calcium carbide, with the carbide content of the brick not exceeding 35 wt. per cent. The bricks can also contain magnesium carbide and suitably contain a total of at least 65% CaO and MgO, up to 4% Al 2 O 3  + SiO 2  and can be given a humidity proof coating of tar, oil or plastics.
Patent GB-1233261-A (GB)
IPC: C07F9/11
Filed: 1968-05-08
Abstract: 1,233,261. Preparing dihydrocarbyl phosphates. BRITISH PETROLEUM CO. Ltd. 31 July, 1969 [8 May, 1968], No. 21696/68. Heading C2C. A dihydrocarbyl phosphate is obtained by reacting a dihydrocarbyl phosphite with bromine and then adding water, the reaction being carried out in the presence of a tertiary amine, preferably an aliphatic tertiaryamine, e.g. triethylamine. The reaction is preferably effected at below 5‹ C. and the process is particularly suitable for the production of dihydrocarbyl phosphates in which the hydrocarbyl radical is an aliphatic radical containing more than 8 carbon atoms, e.g. didodecyl phosphate.
Patent GB-1234117-A (GB)
IPC: G03F9/00
Filed: 1969-06-25
Abstract: 1,234,117. Aligning Masks. FUJITSU Ltd. June 25, 1969 [July 5, 1968] , No.32047/69. Heading G2J. In a photographic mask apparatus it is possible to align a mask on one surface of a wafer with patterns provided on the opposite surface of the wafer, even if the wafer is opaque. The wafer 1 is mounted on a glass 9 and the mask 2 is illuminated, via a partial reflector 10, by a light source 7 whilst the patterns are illuminated, via mirror 12, by a light source 11. An image of the mask is formed by an objective lens 3A and projected to a semi-reflecting surface 5, via a mirror 13, a lens 14 and a mirror 15, whilst an image of the patterns is formed by an objective lens 3B and projected to the semi-reflector 5, via the mirrors 12, 16 and lens 17, and the two images are arranged to have been magnified to the same size when observed together in the eye-piece 6. The desired setting of the mask relative to the patterns can then be obtained with the adjusting device 8 and the wafer and mask are then fixed together. In a modification, Fig. 4 (not shown), observations are taken simultaneously of two distinct regions of the mask and the corresponding regions of the patterns by using a similar optical system with two pairs of objectives, one for each region, and two such combined images are seen in either a monocular or a binocular eye-piece, each combined image only filling half the field of view of each eye lens.
Patent GB-1234380-A (GB)
IPC: A01N43/80
Filed: 1969-07-03
Abstract: 1,234,380. Isothiazolone derivatives. CIBAGEIGY A.G. 3 July, 1969 [5 July, 1968], No. 33556/69. Heading C2C. [Also in Divisions A5 and C5] The invention comprises compounds of formula wherein R 1 , R 2  and R 3  are each H, C 1-4  alkyl, C 1-4  alkoxy, halogen, CF 3  or CN, at least one of R 1 , R 2  and R 3  being halogen. These compounds, as well as their analogues in which R 1 , R 2  and R 3  may be NO 2 , PhO or halogenophenoxy and in which none of them need be halogen, are prepared by reacting the sulphone with CS 2  and a strong alkali, alkylating the product and reacting the intermediate with a chlorinating agent such as SO 2 Cl 2  or Cl 2 , R being alkyl or aryl, and R<SP>1</SP> being C 1-3  alkyl.
Patent GB-1234503-A (GB)
IPC: G05F3/18
Filed: 1969-02-18
Abstract: 1,234,503. Voltage regulators. FISHER RADIO CORP. Feb. 18, 1969 [Feb. 19, 1968], No.8844/69. Heading G3X. A voltage regulator circuit comprises output terminals 12, 14, shunted by a Zener diode 18, having a positive temperature co-efficient, in series with a resistor 20 which has a negative temperature co-efficient. When the temperature changes, the variations in voltage across the respective elements 18, 20, cancel each other so that the potential across terminals 12, 14, remains constant. The series circuit 17 receives constant current from source 30 through a network 24. The base potential of transistor 44 is maintained at a constant level by the circuit 17, whereby the voltage-drop resistor 48 is kept constant. As a result, the current flowing through a transistor 34 to the terminal 12 is maintained at a steady value. If the terminals 12, 14, are short-circuited, the transistors 44, 34, are cut off.