Patent SG-11201909516V-A (SG)
Title: Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
Inventor: SAKAMURI SUKUMAR
IPC: C12N15/117
Filed: 2018-04-13
Abstract: WO 18/ 18938 2 Al FIG. IS 11 - GIN - 1,11311 , 10,“= 1 - 1,C3 tleiter Tel V• (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PCT omit VIII °nolo motioall onoloino oimIE (10) International Publication Number WO 2018/189382 Al (51) International Patent Classification: C12N 15/117 (2010.01) (21) International Application Number: PCT/EP2018/059554 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/485,748 14 April 2017 (14.04.2017) US 62/537,925 27 July 2017 (27.07.2017) US (71) Applicant: SOLSTICE BIOLOGICS, LTD. [IE/IE]; 88 Harcourt Street, Dublin 2 (IE). (72) Inventors: SAKAMURI, Sukumar; 11271 Laurelcrest Drive, San Diego, California 92130 (US). BRADSHAW, Curt W.; 7980 Purple Sage, San Diego, California 92127 (US). LAM, Son; 11334 Del Diablo Street, San Diego, California 92129 (US). STOCK, Joseph; 4707 Otomi Av- enue, San Diego, California 92117 (US). HA, Edward (84) Designated States Hyungsuk; 540 Via de la Valle, Unit F, Solana Beach, Cal- ifornia 92075 (US). ELTEPU, Laxman; 10914 Ivy Hill Way #5, San Diego, California 92131 (US). LIU, Ding- guo; 11736 Miro Cir., San Diego, California 92131 (US). LIU, Bin; 13571 Marguerite Creek Way, San Diego, Cal- ifornia 92130 (US). DELLO IACONO, Giuseppe; 435 Venetia Way, Oceanside, California 92057 (US). MEADE, Bryan R.; 967 Beryl Street, San Diego, California 92109 (US). KABAKIBI, Ayman; 5180 White Emerald Drive, San Diego, California 92130 (US). (74) Agent: JONES DAY; Prinzregentenstr. 11, 80538 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: IMMUNOMODULATING POLYNUCLEOTIDES, ANTIBODY CONJUGATES THEREOF, AND METHODS OF THEIR USE (57) : Immunomodulating polynucleotides are disclosed. The immunomodulating polynu- cleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are con- jugates containing a targeting moiety and one or more immunomodulating polynucleotides. The im- munomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conju- gates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use. [Continued on next page] WO 2018/189382 Al U I TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))