Patent AU-2013201532-B2 (AU)
Title: Methods for treating HCV
Inventor: BERNSTEIN BARRY M
IPC: A61K31/00
Filed: 2012-10-19
Granted: 2014-10-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/059638 Al 25 April 2013 (25.04.2013) WI POI PCT (51) International PatentClassification: Ridge Road, Green Oaks, IL 60048 (US). AWNL Walid, A61K 31/473 (200601) A61P 31/12(2006,01) M.; 14105 Edgewater Court, Green Oaks, IL 60048 (US). A61K31/4025 (2006.01) A61P31/14 (2006.01) DUMAS, Emily, 0.; 232 E Winchester, Libertyville, IL A61K45/06 (2006.01) 161K31/4709(2006.01) 60048 (US). KLEIN, Cheri, E.; 1933 Barberry Road, A61K 31/513(200601) A61K31/51(2006.01) Northbrook, IL 60062 (US). A61K 31/4178(2006.01) A61K31/5377(2006.01) (74) Agents: ZHANG, Xu et at.; 100 Abbott Park Road, Abbott A61K 31/4725 (2006.01) Park, IL 60064 (US). (U) InternatoaakAppLiction4Number (21) International Application Number: PCT/US2012/061085 (81) Designated States (unless otherwise indicated, for eerv kind ofnational protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 19 October 2012(19.10,2012) BZ, CA, CIH CL. CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, F, i, GD, GE, Gi, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KIP, (26) Publication Language: English KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (30) Priority Data: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 61/550,360 21 October 201 (21 10.2011) US RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, 61/562,176 21 November2011 (21.1l.201I) US TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 61/587,197 17 January 2012(17.01.2012) US ZM ZW, 61/600,468 17 February 2012(17.02.2012) US 61/619,883 3 April 2012 (03.04.2012) US (84) Designated States (unless otherwise indicated. for ever 61/656,253 6 June 2012 (06.06.2012) US kind of regional ptection available): ARIPO (BW, GH, 61/711,793 10 October 2012(10.10.2012) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, N WUG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicant: ABBVIE INC. [US/US]; I North Waukegn TM), Europa (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Road, North Chicago, IL 60064 (US). EE, ES, Fl, FR, GB, GR, HR, HIU, IF, IS, IT, LT, LU, LV, (72) Inventors: BERNSTEIN, Barry, M.; 10829 Wyngate MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Trace, Mequotn, WI 53092 (US). MENON, Rajeev, M,; TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 81 Pinyon Pine Court, Buffalo Grove, IL 60089 (US). ML, MR, NE, SN, TD, TO). KHATRI, Amit; 1360 S. White Oak Drive, Apt. 225, Published: Waukegan, IL 60085 (US). MENSING, Sven; Langer Schlag 95a, 68305 Mannheim (DE). DU'TA, Sandeep; - Iwh international search report (Art. 21(3)) 7303 Clem Drive, Cum , IL 60031 (US). COHEN, - beJore the expiration of the time limit for amending he Daniel, E.; 930 Oakwood Avenue, Wilnele, IL 60091 claims and to be republished in the event of receipt of (US). PODSADECKI, Thomas, J.; 708b N. Orleans, amendments (Rule 48.2(h)) Chicago, IL 60654 (US). BRUN, Scott, C.; 31048 Prairie (54) Title: COMBINATION TREATMENT (EG. WITH ABT-072 OR ABT -333) OF DAAS FOR USE IN TREATING [ICV (57) Abstract: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treat N ment is over a shoter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent I (AT) or therapeutic agent 2 (=ABT-333) or thera peutic agent 3 (=AIBT-072) or therapeutic agent 4 (ABT), and an inhibitor ofcytochrome P450 (e.g., ritonavir).