Patent SG-11201901176X-A (SG)
Title: Novel peptides and scaffolds for use in immunotherapy against head and neck squamous cell carcinoma and other cancers
Inventor: MAHR ANDREA
IPC: C07K14/47
Filed: 2017-08-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 111111111101111101001111110101110111111111110111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/037085 Al 01 March 2018 (01.03.2018) W I P0 I P C T (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07K 14/47 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/EP2017/071347 KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 24 August 2017 (24.08.2017) — with international search report (Art. 21(3)) — (25) Filing Language: English before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (26) Publication Language: English amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (30) Priority Data: 10 2016 115 974.3 26 August 2016 (26.08.2016) DE 62/379,864 26 August 2016 (26.08.2016) US (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-Strasse 15, 72076 Tuebingen (DE). (72) Inventors: MAHR, Andrea; Kirschenweg 22, 72076 Tiibingen (DE). WEINSCHENK, Toni; Im Morgenrain 15, 73773 Aichwald (DE). WIEBE, Anita; Quellen- strasse 49, 72124 Ruebgarten (DE). SONG, Colette; Willi- Baumeister-Weg 21, 73760 Ostfildern (DE). SCHOOR, Oliver; Eichhaldenstrasse 19, 72074 Tiibingen (DE). FRITSCHE, Jens; Larchenweg 11, 72144 Dusslingen (DE). SINGH, Harpreet; 5122 Morningside Dr, Apt 525, Houston, Texas 77005 (US). Agent: BOEHMERT & BOEHMERT; Krauss, Jan B., Pettenkoferstrasse 22, 80336 Munich (DE). (74) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (84) = 1-1 in (54) Title: NOVEL PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY AGAINST HEAD AND NECK SQUAMOUS pt CELL CARCINOMA AND OTHER CANCERS 0 IN (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In C particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated ---- T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical * t ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. 1-1 © Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, ei soluble T-cell receptors, and other binding molecules. C