baber/WOPTO huggingface dataset:
Patent AU-2021282411-A1 (AU)
Title: Microfluidic cell culture of patient-derived tumor cell spheroids
Inventor: BARBIE DAVID
IPC: C12N5/09
Filed: 2021-12-07
Abstract: Provided herein are methods for culturing patient-derived tumor cell spheroids in a three
dimensional microfluidic device. The method comprises mincing primary tumor sample in a 
medium supplemented with serum; treating the minced primary tumor sample with a 
5 composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 ptt to 
500 ptu from the enzyme treated sample; suspending the tumor spheroids in biocompatible 
gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods 
for identifying an agent for treating cancer and microfluidic devices that allow for the 
simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a 
10 treatment of choice and to control treatment are also provided.
Patent AU-2021282498-A1 (AU)
Title: A method of operating a gaming machine, a gaming machine and a game controller
Inventor: SALMON CHRISTIAN JAMES
IPC: A63F13/00
Filed: 2021-12-09
Abstract: A gaming machine comprises memory storing a pay table 
comprising a plurality of pay table items, each item 
5 defining a prize and a required winning combination of 
symbols to achieve the respective prize, a pay table 
modifier configured to modify the pay table to apply to at 
least one game outcome by changing the required winning 
combination of symbols associated with a first prize such 
10 that a lower number of symbols are required to achieve the 
first prize, an outcome generator configured to generate 
each at least one game outcome by selecting symbols for 
display in a plurality of columns of symbol display 
positions on a display of the gaming machine, and an 
15 outcome evaluator configured to evaluate the selected 
symbols based on the modified pay table upon the pay table 
being modified.  
17978068_1 (GHMatters) P104332.AU.2 9/12/21
Patent AU-2021286269-A1 (AU)
Title: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients
Inventor: ADAMO ANDREA
IPC: B01J19/00
Filed: 2021-12-14
Abstract: Systems and methods for synthesizing chemical products, including active 
pharmaceutical ingredients, are provided. Certain of the systems and methods described 
herein are capable of manufacturing multiple chemical products without the need to 
5 fluidically connect or disconnect unit operations when switching from one making chemical 
product to making another chemical product.
Patent AU-2021310405-A1 (AU)
Title: Rechargeable battery discharge device for discharging rechargeable batteries, and method for discharging a plurality of rechargeable batteries
Inventor: AHRENS JONATHAN
IPC: H01M50/51
Filed: 2021-07-12
Abstract: The invention relates to a rechargeable battery discharge device (10) for discharging rechargeable batteries (20), comprising (a) a first rechargeable battery connection (12.1) for connecting a first rechargeable battery (20.1), (b) a second rechargeable battery connection (12.2) for connecting a second rechargeable battery (20.2), (c) at least one third rechargeable battery connection (12.3) for connecting a third rechargeable battery (20.3), and (d) a load connection (14) for a load (16) for dissipating an electric output upon discharging the rechargeable batteries (20). According to the invention, (e) a discharge circuit (18) is provided which has (i) a first short circuit switch (24.1), (ii) a first voltage meter (22.1) designed to measure a first rechargeable battery voltage (U
Patent AU-2021320503-A1 (AU)
Title: Equalizing cartridge for a flapper valve
Inventor: JOHNSON JEFFREY
IPC: E21B34/10
Filed: 2021-07-29
Abstract: A one-way valve for use in a wellbore includes a housing having a longitudinal axis defining a flow bore. A valve seat is arranged in the housing along the flow bore. A flapper member is pivotally supported in the housing between a closed position and an open position. The flapper member includes a first side having a sealing surface that selectively engages the valve seat in the closed position and an opposing second side. The flapper member also includes a central portion that is aligned with the longitudinal axis in the closed portion and a passage extending through the flapper member. An equalizing cartridge is arranged in the passage. The equalizing cartridge includes an equalizing housing and an equalizing plunger including an activation end provided at the first side of the flapper member.
Patent AU-2021336074-A1 (AU)
Title: Security marking, method and device for reading the security marking, security document marked with the security marking, and method and system for verifying said security document
Inventor: DINOEV TODOR
IPC: B42D25/369
Filed: 2021-08-30
Abstract: The invention relates to a security marking (100), a method and a device for reading and decoding the security marking (100), a security document (150) marked with the security marking (100), and a method and a system for verifying and authenticating said security document (150). The security marking (100) comprises a machine readable marking (130) overlapping with a magnetically induced layer (120) of a material including magnetically oriented reflective platelet-shaped magnetic or magnetizable pigment particles with two zones (120a) and (120b) of distinct orientations of the particles. The encoded data on the machine readable marking (130) being decodable only after the data separately read from the two zones (120a) and (120b) are gathered.
Patent AU-2021360131-A1 (AU)
Title: Cell-based therapy for viral diseases
Inventor: MEI SHIRLEY H J
IPC: C12N15/12
Filed: 2021-10-15
Abstract: The present application relates to the prevention or treatment of symptoms and diseases caused by viral infections, such as acute respiratory distress syndrome (ARDS), sepsis or septic shock associated with SARS-CoV-2 and influenza virus infections. The treatment is based on the use of mesenchymal stem cells (MSCs) genetically engineered to overexpress suitable polypeptides such as angiopoeitin-1 (ANGPT1) and IFN-induced transmembrane (IFITM). The MSC-based therapy may be administered to the lung of the patient by injection into the blood system.
Patent AU-2021377501-A1 (AU)
Title: Pressure induced deflatable foley's catheter
Inventor: SURESH B
IPC: A61M25/10
Filed: 2021-11-13
Abstract: A catheter (1) is disclosed which has a primary balloon (2) to be inflated or deflated, a pumping means (3) for pumping a working fluid into and out of the primary balloon (2) to inflate or deflate it, and a restraining mechanism (4) to keep a first part (5) of the primary balloon (2) or an opening (7) of the primary balloon (2) in a restrained position until a pressure inside the primary balloon (2) is within a predefined threshold and in an expanded position when the pressure inside the primary balloon (2) surpasses the predefined threshold and until the pressure inside the primary balloon (2) gets below the predefined threshold. This helps in retaining the working fluid inside the primary balloon (2) until the pressure is within the threshold, and to move it out of the balloon when it is beyond the threshold.
Patent AU-2021378793-A1 (AU)
Title: Methods and compositions comprising a krasg12c inhibitor and a pd-l1 binding antagonist for treating lung cancer
Inventor: EVANGELISTA MARIE
IPC: A61K31/517
Filed: 2021-11-11
Abstract: Provided herein are combination therapies (compositions) and methods and uses thereof for the treatment lung cancer, where the combination therapies comprise Compound 1 or a pharmaceutically acceptable salt thereof as described herein and a PD-L1 binding antagonist (e.g., atezolizumab).
Patent AU-2021380039-A1 (AU)
Title: Compositions and methods for the treatment or prevention of preterm labor
Inventor: GOTTELAND JEAN-PIERRE
IPC: A61K31/426
Filed: 2021-11-16
Abstract: The disclosure provides compositions and methods for delaying the onset of delivery in a pregnant subject, such as a pregnant human subject, that is undergoing or at risk of undergoing preterm labor at a gestational age of from about 24 weeks to about 34 weeks. Using the compositions and methods described herein, such subjects may be administered atosiban in combination with a prostaglandin F2α (PGF2α) antagonist. Exemplary PGF2α receptor antagonists that may be used for the treatment or prevention of preterm labor as described herein include 1,3-thiazolidine-2-carboxamide compounds, such as (3S)-3-({[(2S)-3-(biphenyl-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}-amino)-3-(4-fluorophenyl)propyl L-valinate or a pharmaceutically acceptable salt thereof (e.g., (3S)-3-({[(2S)-3-(biphenyl-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}-amino)-3-(4-fluorophenyl)propyl L-valinate hydrochloride). The compositions and methods described herein provide various clinical benefits. Delivery at an early gestational age is a leading cause of perinatal mortality. By delaying labor in pregnant human patients at an early gestational age, the compositions and methods of the disclosure provide unborn infants with additional time to develop vital organs and tissue systems, thereby significantly improving the likelihood of survival following delivery. The compositions and methods described herein may be used to delay the onset of delivery by one or more hours, days, or weeks, for example, so as to enable pregnant subjects to reach a gestational age at which parturition is substantially safer.
Patent AU-2021389155-A1 (AU)
Title: Ransomware mitigation system and method for mitigating a ransomware attack
Inventor: MARTINIC CHRISTOPHER
IPC: G06F21/56
Filed: 2021-11-24
Abstract: The present invention relates to a ransomware mitigation system and methods therefor. The ransomware mitigation system monitors the rate of modification of files on computing devices to determine whether the monitored rate of modifications exceeds a predetermined threshold. If the threshold is exceeded, then the ransomware mitigation system actuates a forced shutdown of the computing device and/or a forced disconnection of the network connection to the computing device. The ransomware mitigation system includes a software monitoring portion as well as a hardware switching unit. The software monitoring portion is in synchronous bidirectional communication with the hardware switching unit on a separate network. If the software monitoring portion is shutdown then the hardware unit actuates the shutdown and/or disconnection of the computing device(s). The hardware unit includes a hardware lock that requires physical presence of a person to allow for maintenance.
Patent AU-2021415837-A1 (AU)
Title: Apparatus for automating inventory and automatic inventory system and method
Inventor: VERMA DINESH C
IPC: G06Q10/08
Filed: 2021-10-26
Abstract: An apparatus for automating inventory procedures for items stored on shelves in a closed environment includes a mobile mechanical device having a movable appendage including a camera and additional sensory modalities. The camera and additional sensory modalities are used to position the movable appendage to take camera images of the items on the shelves from many different perspectives. Camera vision and the additional sensory modalities can be used to rotate, lower and raise movable appendage to position the appendage over and along the sides of the items on the shelf. The context of the mobile mechanical device is determined and edge AI computing retrieves AI context specific models based on the context. The AI context specific models may be downloaded from a cloud service. The edge AI computing uses the AI context specific models to identify and count the items on the shelf.
Patent AU-2021438644-A1 (AU)
Title: Composite membrane of special highly-enhanced fluorine-containing proton or ion exchange membrane, composite membrane electrode, special highly-enhanced fluorine-containing chlor-alkali battery membrane, special release membrane, and preparation method therefor
Inventor: WU HUISHENG
IPC: H01M8/1018
Filed: 2021-12-16
Abstract: Disclosed in the present invention are a composite membrane of a special highly-enhanced fluorine-containing proton or ion exchange membrane, a composite membrane electrode, a special highly-enhanced fluorine-containing chlor-alkali battery membrane, a special release membrane, and a preparation method therefor. The composite film of the special highly-enhanced fluorine-containing proton or ion exchange membrane comprises at least two microporous enhancement membranes, wherein both sides of each microporous enhancement membrane are filled with a fluorine-containing proton or ion exchange resin, the composite film has biaxial tensile strength greater than 40 MPa, room-temperature ionic conductivity greater than 0.007 S/cm, and extremely low air permeability, and it is measured using a Gurley permeability tester that the time required for 100 ml of air to penetrate through the composite membrane is more than 5 minutes.
Patent WO-2022213153-A1 (WO)
Title: Oligonucleotides
Inventor: GANTIER MICHAEL PAUL MARIE
IPC: C12N15/113
Filed: 2022-04-08
Abstract: The present disclosure relates to methods of selecting, designing or modifying oligonucleotides so that they inhibit cyclic GMP-AMP synthase (cGAS), Toll-Like Receptor 3 (TLR3,) Toll-Like Receptor 7 (TLR7), Toll-Like Receptor 8 (TLR8) and/or 5 Toll-Like Receptor 9 (TLR9), or potentiate Toll-Like Receptor 8 (TLR8). Additionally, the present disclosure resides in methods of selecting, designing or modifying oligonucleotides such that they exhibit reduced cGAS inhibitory activity.
Patent WO-2022256882-A1 (WO)
Title: Production of saturated fats in microbes
Inventor: EL TAHCHY ANNA
IPC: C12P13/00
Filed: 2022-06-10
Abstract: The present invention relates to extracted microbial lipids, microbial cells comprising the lipid, and extracts thereof. The present invention also relates to use of these lipids, cells and extracts in foods, feedstuffs and beverages.
Patent WO-2023283696-A1 (WO)
Inventor: JUREY HAYDEN CHARLES
IPC: E04B1/41
Filed: 2022-07-15
Abstract: An attachment for positioning a cast-in-place anchor bolt relative to concrete formwork prior to pouring of concrete therein, comprising: an upper body having an opening for receiving and supporting a lower end of the bolt such that it is spaced from the 5 formwork; legs extending downwardly from the upper body; and a substantially continuous base configured for, in use, placement against and securement to formwork so as to fix a position of the bolt relative thereto, the base being associated with respective lower ends of the legs so as to maintain the upper body thereabove.
Patent AU-2022200669-A1 (AU)
Title: Device and method for measuring extension-retraction stroke of hydraulic cylinder
Inventor: PANG YIHUI
IPC: E21C45/08
Filed: 2022-02-02
Abstract: A device and method for measuring an extension-retraction stroke of a hydraulic cylinder 
is disclosed. The device includes a fixed sleeve, a telescopic damper and a distance-measuring 
roller. The fixed sleeve includes a bearing sleeve, a flexible sealing sleeve, a connecting
fixing lug plate, and a roller-limiting lug plate. The distance-measuring roller includes an 
elastic contact sleeve, a shaft encoder, and a position-limiting connection shaft. Two fixed 
sleeves, eight telescopic dampers, and four distance-measuring rollers can be assembled into 
the device. When the hydraulic cylinder is retracted, a telescopic section of the hydraulic 
cylinder drives shaft encoders of four distance-measuring roller to rotate, and the extension
retraction stroke of the hydraulic cylinder can be calculated by a direction of rotation and the 
number of turns of rotation of the shaft encoder.
1/5 
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31 
21 
17 
FIG. 2
Patent AU-2022201093-A1 (AU)
Title: A snatch ring for off-road vehicle recovery
Inventor: SCHIPPER TROY
IPC: B66D3/04
Filed: 2022-02-18
Abstract: A snatch ring for off-road vehicle recovery has an annular core and an outer sheave.  
The outer sheave has an outer winch line groove and the annular core and the outer 
sheave are concentric. The annular core is rotatably engaged to the outer sheave so 
that the annular core and the outer sheave can rotate with respect to each other 
about an axis of rotation. The annular core has an anchor loop passage therethrough.  
10
1/3 
110 
109 
112 
100 
104 
107 
108 
FIG. 1 
100 104 
101 
107 
102 
FIG. 2
Patent AU-2022201713-A1 (AU)
Title: Floor mat with hidden base component
Inventor: PUTHILLATH PADMAKUMAR
IPC: B60N3/04
Filed: 2022-03-11
Abstract: This invention relates to a washable multi-component magnetic floor mat with a 
hidden base component. The floor mat contains a textile component and a base 
component. The textile component and the base component are attached to one 
another by magnetic attraction. The magnetic attraction is provided by incorporation 
of magnetic particles in both the textile and base components. The textile component 
is designed to be soiled, washed, and re-used, thereby providing ideal end-use 
applications in areas such as building entryways. The present invention eliminates 
the need to wash the base component of the floor mat which results in environmental, 
cost and labor conservation. Alignment and deployment of the textile component with 
the base component in an efficient manner is also described herein.
Patent AU-2022202738-A1 (AU)
Title: Methods And Materials For Producing Recombinant Viruses In Eukaryotic Microalgae
Inventor: KASPAR BRIAN K
IPC: C12N15/63
Filed: 2022-04-26
Abstract: pChiamy_4 
3640 bp 
FIGURE 1 
The present invention is directed to methods and materials for producing 
recombinant viruses. In particular, methods and materials are provided for producing 
recombinant viruses in eukaryotic microalgae such as Chlamydomonas reinhardti.  
Recombinant adeno-associated viruses are examples of recombinant viruses 
produced according to the invention.
Patent AU-2022203921-A1 (AU)
Title: Saposin-a derived peptides and uses thereof
Inventor: WATNICK RANDOLPH S
IPC: A61K38/08
Filed: 2022-06-06
Abstract: Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity 
that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 
or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core 
amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino 
acid substitutions are disclosed herein. In some embodiments, the peptide consists 
essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed 
herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, 
and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases 
and disorders such as cancer and cancer metastasis.
Patent AU-2022206701-A1 (AU)
Title: Diagnosis and treatment of infectious disease
Inventor: LEE HELEN
IPC: C12Q1/68
Filed: 2022-07-18
Abstract: Diagnosis and Treatment of Infectious Disease 
Methods are described for determining whether a subject suffering from, or suspected of 
suffering from, an infectious disease caused by a microbe is infected with a strain of the 
5 microbe that is susceptible to an antimicrobial agent, where there exist different strains of 
the microbe that are resistant to the antimicrobial agent. The methods comprise 
determining whether nucleic acid of the strain of the microbe infecting the subject 
comprises wild-type nucleotide sequence at a conserved nucleotide position at which 
mutation is associated with resistance to the antimicrobial agent in nucleic acid of the 
10 different resistant strains. The methods are particularly applicable for determining whether 
a subject suffering from, or suspected of suffering from, Gonorrhoea is infected with a 
strain of Neisseria gonorrhoeae that is susceptible to an antimicrobial agent. Kits for use in 
the methods are described, as well as methods for treatment of infectious disease.  
Methods for reducing the prevalence of resistance of microbes causing infectious disease 
15 to antimicrobial agents are also described.
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Patent AU-2022220196-A1 (AU)
Title: Compositions comprising exopolysaccharides and uses thereof
Inventor: DURMONT FRÉDÉRIC
IPC: A61K31/715
Filed: 2022-02-10
Abstract: The present disclosure relates to exopolysaccharides produced by marine bacteria, compositions thereof, the use of said compositions, and a method for attenuating the virulence of a microbial pathogen infection, either bacterial or viral infections, by inhibiting or reducing colonization of said microbial pathogens onto biological and/or non-biological surfaces.
Patent AU-2022225061-A1 (AU)
Title: Method for determining a membrane property of an analyte sensor
Inventor: SLIOZBERG KIRILL
IPC: A61B5/145
Filed: 2022-02-23
Abstract: A method for determining at least one membrane property of an analyte sensor (112) is pro-posed. The analyte sensor (112) comprises at least two measurement electrodes (114). At least one of the measurement electrodes (114) comprises at least one membrane element (122) having at least one membrane property. The method comprising the following steps: a) (134) generating at least one fast-transient voltage signal and applying the fast-transient voltage signal to the measurement electrodes (114) at an application time t
Patent AU-2022231782-A1 (AU)
Title: System and method for monitoring an oxidation catalyst
Inventor: OTT TREVOR JOSEPH
IPC: F01N11/00
Filed: 2022-09-16
Abstract: A lean-bum internal combustion engine and an exhaust aftertreatment system having 
an oxidation catalyst are described. A controller determines a fueling rate and a mass 
flowrate of the exhaust gas feedstream. An inlet temperature of the exhaust gas feedstream 
upstream of the oxidation catalyst is determined via the first temperature sensor, and an in-use 
outlet temperature of the exhaust gas feedstream is determined downstream of the oxidation 
catalyst via the second temperature sensor. An expected outlet temperature from the 
oxidation catalyst is determined based upon the inlet temperature, the fueling rate, and the 
mass flowrate of the exhaust gas feedstream. The oxidation catalyst is evaluated based upon 
the expected outlet temperature and the in-use outlet temperature.  
19052467_1 (GHMatters) P119985.AU
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Patent AU-2022248168-A1 (AU)
Title: Crystalline form of pyrrole amide compound, preparation method therefor and use thereof
Inventor: Zong qiao
IPC: C07D207/325
Filed: 2022-03-28
Abstract: Provided are a crystalline form of a pyrrole amide compound, a preparation method therefor and a use thereof, and also provided is a pharmaceutical composition comprising the crystalline form. In particular, the crystalline form or the pharmaceutical composition can be used to treat and prevent diseases such as hyperaldosteronism, diabetic nephropathy, hypertension, heart failure (comprising chronic heart failure, etc.), sequelae of myocardial infarction, liver cirrhosis, renal failure, and stroke.
Patent AU-2022248913-A1 (AU)
Title: Novel pd-1 binding domains
Inventor: PLYTE SIMON EDWARD
IPC: C07K16/28
Filed: 2022-03-31
Abstract: The present disclosure relates to novel PD-1 binding domains that have a higher binding affinity for human PD-1 than a reference PD-1 binding domain. The PD-1 binding domains of the present disclosure further provide a comparable, or equal or higher, potency in blocking ligand binding to human PD-1 than a reference PD-1 antibody. The present disclosure further relates to binding moieties comprising such PD-1 binding domains. Also provided is a method for treating a disease, in particular a disease associated with a suppressed immune system, such as cancer, with a PD-1 binding domain or binding moiety of the present disclosure. The present disclosure further relates to nucleic acids encoding the heavy chain variable region of the PD-1 binding domains, and a vector and cell comprising such nucleic acid.