baber/WOPTO huggingface dataset:
Patent RU-2731293-C1 (RU)
Title: Method of producing genetically modified lines of cells of natural killers with knockout pd-1 gene and high expression of proteins of family of tumour necrosis factor for immunotherapy of oncological diseases
Inventor: BELETSKIJ IGOR PETROVICH
IPC: A61K35/17
Filed: 2019-04-12
Granted: 2020-09-01
Abstract: FIELD: medicine. 
     SUBSTANCE: this group of inventions refers to medicine and genetic engineering. Disclosed are methods of producing modified killer (NK) cell lines with knockout PD-1 gene or, in other embodiments, with knockout PD-1 gene and constitutive high expression of Fas-ligand, or with knockout PD-1 gene and constitutive high expression of TRAIL. What is also described is a method of selecting modified NK cells with knockout PD-1 gene, which is carried out using a selective zeocin marker. What is also presented is using the obtained cell lines in order to induce apoptosis or lysis of mammalian cancer cells. 
     EFFECT: present group of inventions provides high output of modified NK cell lines exhibiting high tumour cell growth inhibition activity. 
     14 cl, 4 dwg
Patent RU-2706107-C1 (RU)
Title: Method of producing complex carbon fibrous material
Inventor: CHERNENKO DMITRIJ NIKOLAEVICH
IPC: D01F9/16
Filed: 2019-04-29
Granted: 2019-11-13
Abstract: FIELD: technological processes. 
     SUBSTANCE: invention relates to production of high-temperature materials used for heat insulation of thermal equipment, as well as reinforcing filler of composite materials. Method of producing complex carbon fibrous material involves continuous carbonization and graphitization of a nonwoven fibrous web containing cellulose. During its transportation, reinforcing component or substrate is represented by cellulose tissue subjected to complex finishing. Initial dry nonwoven fabric is placed on the wet prepared textile substrate impregnated with a catalyst solution. Produced pack is passed between squeezing rollers. Then the bag is treated in a superheated air-steam medium, dried, subjected to intensive heating for 1–3 minutes to the beginning temperature of pyrolysis of cellulose macromolecules. Heated package, not allowing cooling, is moved from intensive heating chamber into first heating zone of carbonization chamber. Carbonization and graphitization of the packet is carried out. 
     EFFECT: higher intensity and efficiency of the process of producing complex carbon fibrous material and improved quality thereof. 
     3 cl
Patent RU-2722395-C1 (RU)
Inventor: YAVUZ EMRE
IPC: H04W76/28
Filed: 2017-11-03
Granted: 2020-05-29
Abstract: FIELD: wireless communication equipment.SUBSTANCE: invention relates to wireless communication. Method of controlling delay of passage of data packets, which is implemented by a wireless communication device, connected to an access unit in a wireless communication network, for controlling the end-to-end delay of through passage of a packet through a packet stream, established between a wireless communication device and another device, comprises steps of: measuring (200) the through packet end-to-end propagation delay between the wireless communication device and the other device; and, in response to determination (202), transmitting, that the through packet end-to-end propagation delay does not correspond to the target packet end-to-end propagation delay for the packet stream, indicating an adjustment to an access node for adjusting the delay of a wireless communication packet between a wireless communication device and an access node through which a packet stream is delivered, wherein, if the adjustment indication is the same as the last adjustment indication, the adjustment indication is not transmitted.EFFECT: technical result consists in reduction of power consumption and improved coverage of wireless communication device.40 cl, 1 tbl, 10 dwg
Patent RU-2718903-C1 (RU)
Title: Method of producing biological material transferred for genetic research in programs of preimplantation genetic testing of human embryos
Inventor: ZAKHAROVA ELENA EVGENEVNA
IPC: G01N33/48
Filed: 2019-07-09
Granted: 2020-04-15
Abstract: FIELD: medicine. 
     SUBSTANCE: invention refers to medicine, namely to reproductive medicine, clinical embryology and genetics. Method of producing material transmitted to genetic diagnostics in programs of preimplantation genetic testing of human embryos, involving the following stages: cultivation of embryos at the stage of compact morula in the medium free from Ca 2+  ions, biopsy of cells of the decomposed morula, short-term  in vitro  cultivation of embryo cells produced as a result of biopsy, with natural increase of their quantity. 
     EFFECT: method enables increasing the volume of living cell material for analysis, which simplifies the analysis and provides more reliable genetic test results, including simultaneous application of several diagnostic methods. 
     3 cl, 3 dwg, 4 ex
Patent RU-2740751-C1 (RU)
Inventor: KRASILNIKOV IGOR VIKTOROVICH
IPC: A61K39/145
Filed: 2019-08-28
Granted: 2021-01-20
Abstract: FIELD: medical biotechnology. 
     SUBSTANCE: invention relates to a method for producing influenza vaccine. Method for producing a tetravalent subunit influenza vaccine involves culturing influenza viruses of subtypes A (H 1 N 1 ), A (H 3 N 2 ), B/Yamagata lineage, B/Victoria lineage in developing chicken embryos with subsequent separation of virus-containing allantoic liquid, concentration, purification, inactivation and splitting of virus, its subsequent centrifugation and ultrafiltration, bringing monovaccine into polyvaccine with the adjuvant, wherein the virus is cultured separately, and after ultrafiltration in each of the monopreparations is introduced as an adjuvant betulin in ratio of antigen: carrier 1:1.25–12.5. 
     EFFECT: use of the given invention enables to obtain a stable and effective tetravalent subunit anti-influenza vaccine when included as an adjuvant of betulin in a weight ratio of the antigen: carrier of 1: 1.25–12.5. 
     1 cl, 4 tbl, 8 ex
Patent RU-2726223-C1 (RU)
Inventor: Grigorev Sergej Nikolaevich
IPC: H01J27/04
Filed: 2019-11-28
Granted: 2020-07-10
Abstract: Изобретение относится к ионно-плазменной технологии и может быть использовано для осаждения покрытий на изделия в вакууме. Магнетронное распылительное устройство содержит плоскую круглую мишень, являющуюся катодом тлеющего разряда, магнитную систему, один из полюсов которой прилегает к центру внешней поверхности мишени, вакуумную камеру, являющуюся анодом тлеющего разряда, и источник питания тлеющего разряда, соединенный отрицательным полюсом с мишенью, а положительным полюсом - с вакуумной камерой, снабжено охватывающим мишень и соединенным с ней электрически цилиндрическим электродом, а второй полюс магнитной системы прилегает к внешней поверхности цилиндрического электрода. Технический результат - расширение эксплуатационных возможностей за счет повышения эффективности использования материала мишени, а также снижение затрат на изготовление распыляемых мишеней. 1 ил.
Patent RU-2721200-C1 (RU)
Title: Method for thermo-chemical treatment of oil reservoir
Inventor: KHISAMETDINOV MARAT RAKIPOVICH
IPC: E21B43/22
Filed: 2019-12-09
Granted: 2020-05-18
Abstract: FIELD: oil and gas industry. 
     SUBSTANCE: invention relates to oil industry, in particular, to methods for thermo-chemical treatment of oil reservoir. Proposed method comprises simultaneous or sequential pumping of two aqueous solutions representing thermochemical composition in volume ratio of 1:1. First aqueous solution contains components, wt%: ammonium nitrate – 30–40, sulphamic acid – 8–12, ammonium bicarbonate – 5–10, fresh water – the rest, the second one – sodium nitrite with concentration of 40–45 wt%. After pumping of aqueous solutions there performed is successive pumping of acid composition containing inhibited hydrochloric acid with concentration of 60 wt%, sulfamic acid – 2 wt%, ammonium acetate – 3 wt%, neonol AF9-12 – 0.15 wt% fresh water – balance, and high-viscosity polymer composition. High-viscous polymer composition contains the following components, wt%: polyacrylamide – 0.1–0.6, 10 % solution of chromium potassium alum – 0.1–0.6, fresh water – balance. Thermochemical composition, acid composition and high-viscosity polymer composition is pumped in volume ratio 1:(0.5–2):(0.5–1), they are pumped into the formation by water, the well is stopped for process exposure for 4 hours and flooding is resumed. For highly-receiving wells prior to thermochemical composition pumping highly-viscous polymer composition is injected at their volume ratio of 1:(1–3). 
     EFFECT: increased coverage of formation by action and connection of low-permeable oil-saturated interlayers increases oil recovery, reduced water content of extracted products. 
     1 cl, 3 tbl
Patent RU-2735219-C1 (RU)
Inventor: Pendyurin Evgenij Aleksandrovich
IPC: C09K17/00
Filed: 2020-04-03
Granted: 2020-10-28
Abstract: FIELD: agriculture. 
     SUBSTANCE: invention relates to agriculture and can be used for creation of artificial soil-melting plants intended for cultivation of crops and during biological stage of reclamation of technogenic-disturbed territories. Artificial soil mixture contains clay, citric acid production wastes – citrogypsum, Hermetia illucens biocompost, wastes of wet magnetic separation of iron ore beneficiation, sand at following content of components, wt%: clay 30–35, citrogypsum 15–20, Hermetia illucens biocompost 10–20, wastes of wet magnetic separation of concentration of iron ore 5–20, sand – the rest. 
     EFFECT: invention provides potting soils with high fertility rates, which ensure an increase in yield. 
     1 cl, 7 tbl
Patent RU-2747583-C1 (RU)
Title: Method for synthesis of (2r, 3s)-isocitric acid from sunflower seed oil using yarrowia lipolytica yeast
Inventor: SAMOJLENKO VLADIMIR ALEKSANDROVICH
IPC: C12P7/48
Filed: 2020-05-26
Granted: 2021-05-11
Abstract: FIELD: chemistry. 
     SUBSTANCE: group of inventions relates to the area of microbiological production of organic acids, particularly (2R,3S)-isocitric acid. Proposed are a yeast strain Yarrowia lipolytica VKM Y-3044D-producer of (2R,3S)-isocitric acid and a method of synthesis thereof involving cultivation of the yeast strain Yarrowia lipolytica VKM Y-3044D on a nutrient medium containing sunflower seed oil as a carbon source, a nitrogen source, trace elements, thiamine and Fe 2+  ions in a defined amount, in conditions of aeration and stirring until the maximum accumulation of the target product in the medium. During the period from 20 to 24 hours of cultivation itaconic acid is introduced into the medium in form of sodium salt in a defined amount. 
     EFFECT: group of inventions allows raising the yield of a target product. 
     3 cl, 1 tbl, 3 ex
Patent RU-2744739-C1 (RU)
Inventor: KROLEVETS ALEKSANDR ALEKSANDROVICH
IPC: A61K9/51
Filed: 2020-06-25
Granted: 2021-03-15
Abstract: FIELD: pharmaceutical industry. 
     SUBSTANCE: invention relates to the field of pharmaceuticals, and in particular to a method for producing nanocapsules of dry Boswellia extract. The method is characterized in that sodium carboxymethyl cellulose is used as the shell of nano-capsules, and dry extract of boswellia is used as the core, while dry extract of boswellia is added to the suspension of sodium carboxymethyl cellulose in isoheptane in the presence of an ester of glycerol with one or two molecules edible fatty acids and one or two molecules of citric acid as a surfactant with stirring at 700 rpm, then fluorobenzene is added, the resulting suspension of nanocapsules is filtered and dried at room temperature, while the mass ratio of the core: shell is 1:1, 1:2 or 1:3. 
     EFFECT: simplification and acceleration of the process of obtaining nanocapsules of Boswellia, reduction of losses during the production of nanocapsules. 
     1 cl, 3 ex
Patent RU-2744730-C1 (RU)
Inventor: Ivashenenko Ivan Nikolaevich
IPC: A01G7/00
Filed: 2020-08-07
Granted: 2021-03-15
Abstract: FIELD: agriculture. 
     SUBSTANCE: invention relates to the field of agriculture, in particular to plant growing and plant breeding. The method includes measuring the height of plants in the flowering phase, accounting for the yield of green mass in the phase of milky-wax ripeness and grain. Before laying the experiment, the plot is divided into two backgrounds: without fertilization and with pre-sowing nitrogen fertilization. The test samples of corn are sown on two backgrounds. During the growing season, the reaction indicator is calculated based on the quantitative characteristics of corn, including grain in the phase of full ripeness, and the indicator of the reaction of corn to nitrogen fertilization is calculated by the formula: 
     
       
     
     where Ra is an indicator of the reaction to nitrogen fertilization; ph 1,  ph 2  - the height of corn plants, respectively, on the control and on the fertilized background; gm 1 , gm 2  - the yield of green mass in the milky-wax ripeness of corn, respectively, on the control and on the fertilized background; gy 1 , gy 2  - grain yield of corn samples, respectively, on the control and on the fertilized background; and the higher the Ra index, the higher the responsiveness of the corn sample.  
     EFFECT: invention improves efficiency and accuracy of assessing the responsiveness of hybrids, self-pollinated lines or corn source material for nitrogen fertilization, as well as simplifies technology of sampling and their evaluation. 
     1 cl, 3 tbl, 1 ex
Patent RU-2743226-C1 (RU)
Inventor: Monakhov Sergei Aleksandrovich
IPC: E02D31/02
Filed: 2020-08-28
Granted: 2021-02-16
Abstract: FIELD: construction.SUBSTANCE: invention relates to the field of construction, namely to the system of hydraulic protection of the underground part of the building. System of hydraulic protection of the underground part of the building contains a multi-layered structure outside the underground part of the building, including the foundation plate and the underground part of the walls, with an outer waterproof layer, forming a continuous closed loop of waterproofing along the underground part of the building, and with a drainage layer located between the underground part of the building and waterproof layer. The invention contains at least one drainage tray designed to collect and drain water, which is completely located under the foundation plate and the drainage layer and is bounded from below by the specified waterproof layer. The drainage layer is designed to drain water into the specified one drainage tray throughout the specified one drainage tray.EFFECT: technical result is to increase drainage efficiency, simplify hydraulic protection design, simplify and accelerate forming hydraulic protection process.13 cl, 2 dwg
Patent RU-2749827-C1 (RU)
Title: Communication method, communication device and network device
Inventor: SU YUWAN
IPC: H04W74/08
Filed: 2018-02-12
Granted: 2021-06-17
Abstract: FIELD: communications.SUBSTANCE: invention relates to the field of communications. The terminal device defines a random access preamble, which includes six groups of symbols; the terminal apparatus determines the frequency location of the random access preamble based on the random access configuration information and a predetermined rule, where the frequency hopping interval between the first and second groups of symbols and the frequency hopping interval between the fifth and sixth groups of symbols are equal and both are the first intervals, the frequency hopping interval between the second and third symbol groups and the frequency hopping interval between the fourth and fifth symbol groups are equal and both are second intervals, and the hopping interval between the third and fourth symbol groups is the third interval; and sending, by the terminal device, a random access preamble based on frequency location.EFFECT: provided is possibility of performing random access based on the frequency hopping scheme, which corresponds to the modernized random access preamble.25 cl, 11 dwg, 3 tbl
Patent RU-2755474-C1 (RU)
Inventor: VOLK VLADIMIR IVANOVICH
IPC: G21C19/00
Filed: 2020-12-04
Granted: 2021-09-16
Abstract: FIELD: crystallization technologies.  
     SUBSTANCE: group of inventions relates to heat and mass transfer processes in systems with liquid and solid phases, namely, to a method for crystallization separation and purification of uranyl nitrate hexahydrate, which includes the crystallization of uranyl nitrate hexahydrate from a concentrated nitric acid solution of uranyl nitrate, a feed stream with a composition corresponding to the ratio [UN]=78.49 - k[HNO 3 ], where [UN] and [HNO 3 ] are the concentrations of uranyl nitrate and nitric acid, wt. % ; where 78.49 is the concentration of uranyl nitrate in the crystalline uranyl nitrate hexahydrate, wt. %; k - the coefficient determining the position of the working line of the crystallization process and having a numerical value from 1.50 to 2.24, preferably from 1.57 to 1.80, separation of crystals of uranyl nitrate hexahydrate and the mother solution, countercurrent washing of crystals, collection of crystals of uranyl nitrate hexahydrate into a collection tank with simultaneous displacement of the washing solution from the tank into the washing zone and unloading of the purified product, and crystallization of uranyl nitrate hexahydrate from the feed stream, washing and collection of crystals it is carried out under isothermal conditions, while the initial, including the non-uranium composition of the washing solution meets the condition of the family of working lines 78.49=k 1 [HNO 3 ], where [HNO 3 ] is the content of nitric acid in the washing solution, wt. % and k 1 ≤k, where k 1  is the coefficient determining the position of the working line of the washing process, the mother solution and the spent washing solution are sent in a single stream to additional crystallization carried out at a temperature below the crystallization temperature with countercurrent movement of the liquid and solid phases, the crystals of uranyl nitrate hexahydrate of additional crystallization are washed together with the crystals obtained from the feed stream, and the mother solution of additional crystallization is removed from the process. In addition, a device for crystallization separation and purification of uranyl nitrate hexahydrate is described, containing an additional mold with a paddle agitator and a thermostatic case mounted on the outlet of the mother and washing solutions, while the axis of the additional mold is parallel to the axis of the mold.  
     EFFECT: simplifying the technological process by achieving high and independent indicators for the operational yield and purification of the product, which can be used in hydrometallurgical technologies of the nuclear fuel cycle at the stages of refining natural or regenerated uranium.  
     4 cl, 3 dwg, 1 tbl
Patent RU-2760364-C1 (RU)
Title: Ballast and cargo tank of an underwater gas tanker for transportation of liquefied gases, predominantly liquefied natural gas
Inventor: Grebennikov Viktor Ilich
IPC: B63B11/04
Filed: 2021-06-07
Granted: 2021-11-24
Abstract: FIELD: shipbuilding. 
     SUBSTANCE: invention relates to the field of shipbuilding and can be used in underwater gas tankers and methane tankers. Proposed is a ballast and cargo tank of an underwater gas tanker for transportation of liquefied gases, predominantly liquefied natural gas, including a heat-insulated metal body with end bulkheads, made of a material resistant to low temperatures, pipelines and fittings for supplying and removing liquefied gas, providing ventilation and control. At least one vertical transverse heat-insulated movable divider, sealed along the external and internal contact surfaces, is installed in the internal space of the horizontally oriented body of the tank, configured to be moved horizontally along the central longitudinal guide by means of a drive. At least one elastic waterproof folding container is installed between at least one transverse movable divider and at least one end bulkhead of the tank, configured for the volume thereof to be increased or reduced in the longitudinal direction multiple times when moving at least one transverse movable divider. At least one elastic container is therein tightly connected by the movable side thereof with the transverse movable divider and by the fixed side with the end bulkhead of the tank, installed wherein are pipelines and fittings for filling at least one elastic container with ballast water and for draining said container. The body of the tank and the central longitudinal guide are equipped with heat insulation means for heat protection of at least one elastic container from low temperatures. 
     EFFECT: expanded functional capabilities of the ballast and cargo tank and, as a result, reduction in the total displacement of the underwater gas tanker. 
     10 cl, 6 dwg
Patent RU-2762883-C1 (RU)
Inventor: MAKAROV VYACHESLAV PETROVICH
IPC: B64G1/22
Filed: 2021-06-25
Granted: 2021-12-23
Abstract: Изобретение относится к области космической техники, а более конкретно к адаптерам для соединения отсеков и блоков летательных аппаратов. Адаптер содержит усеченную коническую оболочку, выполненную зацело с двумя торцевыми шпангоутами разного диаметра. Верхний шпангоут адаптера снабжен равномерно размещенными вдоль него отверстиями, выполненными с обеспечением возможности размещения в них элементов крепления верхнего шпангоута с полезной нагрузкой. Адаптер выполнен с высотой, не менее чем в 6 раз меньшей диаметра нижнего шпангоута. Оболочка адаптера выполнена с плавным увеличением ее толщины при переходе от шпангоута с меньшим диаметром к шпангоуту с большим диаметром, причем углы наклона образующих наружной и внутренней поверхностей оболочки к продольной оси адаптера выбраны близкими 45 и 50 градусам соответственно. Оболочка снабжена вырезами, выполненными в виде равнобедренных треугольников со скругленной вершиной, боковые стороны которых соединены с опорными узлами нижнего шпангоута адаптера. Каждый из вырезов выполнен с высотой, не менее чем в 2 раза меньшей высоты адаптера. В каждой из продольных плоскостей, совмещенных с осями отверстий опорных узлов нижнего шпангоута адаптера, и в каждой из продольных плоскостей, совмещенных с вершинами указанных вырезов, размещена ось одного из отверстий верхнего шпангоута. Достигается расширение функциональности. 1 з.п. ф-лы, 9 ил.
Patent RU-2768831-C1 (RU)
Inventor: Zajtsev Nikolaj Konkordievich
IPC: B01D53/34
Filed: 2021-07-05
Granted: 2022-03-24
Abstract: FIELD: gas purification.  
     SUBSTANCE: invention relates to the field of purification of gas mixtures from carbon dioxide impurities and can be used in various fields of science and technology. The gas stream to be cleaned is bubbled using a divider through a suspension of finely crushed carbonate of at least one alkaline earth metal while stirring the suspension solution in a bubbling chamber. The specified suspension saturated with carbon dioxide is filtered on a dynamic filtration unit through a rotating membrane filter in the ultrasound field. The filtrate is placed in the degassing chamber, and the unfiltered part is returned to the bubbling chamber.  
     EFFECT: invention provides an increase in the efficiency of carbon dioxide extraction from gas mixtures.   
     7 cl
Patent DE-2943301-C2 (DE)
IPC: G04D7/00
Filed: 1979-10-26
Granted: 1982-05-19
Abstract: An electronic measuring apparatus for measuring the rate of an analog-display electronic watch which comprises a quartz oscillator, a frequency divider with an adjustable division factor, a stepping motor and a circuit which, when the stem of the watch is pulled, produces a measuring signal emitted by the stray field of the coil of the stepping motor and comprising trains of pulses whose period and content are respectively representative of the frequency of the oscillator and the division factor. The measuring apparatus comprises a pick-up means for detecting said measuring signal, circuits for computing the rate of the watch and means for displaying said rate.