baber/WOPTO huggingface dataset:
Patent WO-2019191552-A1 (WO)
Title: Modulating lactogenic activity in mammalian cells
Inventor: MISAGHI SHAHRAM
IPC: C12N5/10
Filed: 2019-03-29
Abstract: The present disclosure relates to methods, cells and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interests, where the cells (e.g, Chinese Hamster Ovary (CHO) cells) have modulated lactogenic activity. The present disclosure also relates to methods and compositions for modulating pyruvate kinase muscle (PKM) expression (e.g, PKM-l expression) in a mammalian cell to thereby reduce or eliminate the lactogenic activity of the cell, as well compositions comprising a cell having reduced or eliminated lactogenic activity and methods of using the same.
Patent WO-2019191704-A1 (WO)
Title: Constructs targeting cd22 and uses thereof
Inventor: CUI JUN
IPC: C07K16/30
Filed: 2019-03-29
Abstract: Described herein are antibodies ( e.g. , single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof ( e.g. , SEQ ID NO:205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.
Patent WO-2019195725-A1 (WO)
Title: Insurance risk evaluation systems and methods
Inventor: HIBLER GLENN
IPC: G06Q10/10
Filed: 2019-04-05
Abstract: An underwriting and risk management computing system is provided to utilize data science and machine learning to enable decision making and risk assessment. Predictive analytics utilizing expanded datasets can provide insightful data that is usable for insurance underwriting and provides actionable intelligence to stakeholders.
Patent WO-2019204507-A1 (WO)
Title: Methods for determining vaccine potency
Inventor: TUCKER WARD
IPC: G01N33/50
Filed: 2019-04-17
Abstract: Compositions and methods for determining the efficacy and/or potency of a vaccine preparation are described herein. Splenocytes from immunized animals are isolated and frozen. Upon thawing aliquots these cells are activated by exposure to a series of dilutions of q vaccine preparation being tested and a series of dilutions of a reference vaccine with known characteristics. Cells secreting immunogen-specific antibody and cells secreting nonspecific antibody are enumerated, as is the amount of immunogen-specific and nonspecific antibody produced. Comparison between the results from the vaccine preparations provides a measure of relative vaccine efficacy and/or potency.
Patent WO-2019213078-A1 (WO)
Title: Biological fluid micro-sample management device
Inventor: EDELHAUSER ADAM
IPC: A61B5/153
Filed: 2019-04-30
Abstract: A biological fluid collection device (10) that receives a sample (12) and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro- sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications. Advantageously, a biological fluid collection device of the present disclosure includes an internal vacuum (28). In this manner, a biological fluid collection device of the present disclosure eliminates the need for additional vacuum creating components that must be connected to the biological fluid collection device during use.
Patent WO-2019226476-A1 (WO)
Title: Adjustable method for sustainable human cognitive enhancement
Inventor: MEE JOHN
IPC: C12N15/09
Filed: 2019-05-17
Abstract: A method of achieving sustainable, general purpose cognitive enhancement in mentally healthy adults comprising administering a gene editing endonuclease complexed with a gene expression inhibiting nucleotide and a synthetic guide RNA to lower the population of 5-hydroxytryptamine 2A receptors in the brain.
Patent WO-2019226687-A1 (WO)
Title: Pyrididne-sulfonamide derivatives as sodium channel inhibitors
Inventor: MCKERRALL STEVEN
IPC: A61P9/00
Filed: 2019-05-21
Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y 1 -Y 6 , X, Z, Z 1 , Z 2 , R 2 -R 3 , and R 6  have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain
Patent WO-2019232302-A1 (WO)
Title: Optoelectronic memristor devices
Inventor: DEFFERRIERE THOMAS
IPC: G02F1/15
Filed: 2019-05-31
Abstract: An optoelectronic memristor includes a first electrode, a second electrode, and a solid electrolyte in between that is in electrical communication with the first electrode and the second electrode. The solid electrolyte has an electronic conductivity of about lCT10 Siemens/cm to about lCT4 Siemens/cm at room temperature. The first electrode, and optionally the second electrode, can be optically transparent at a specific wavelength and/or a wavelength range. A direct current (DC) voltage source is employed to apply an electric field across the solid electrolyte, which induces a spatial redistribution of ionic defects in the solid electrolyte. In turn, this causes a change in electrical resistance of the solid electrolyte. The application of the electric field can also cause a change in an optical property of the solid electrolyte at the specific wavelength, and/or at the wavelength range (or a portion thereof).
Patent WO-2019241074-A1 (WO)
Title: Method and apparatus for increasing absorption of medications and cosmeceuticals through the skin of the user
Inventor: SHEFTEL SCOTT
IPC: A61N1/30
Filed: 2019-06-07
Abstract: The present invention provides a device for increasing absorption of substances through the skin of an animal or human, comprising: a fabric or substrate; metal particles disposed on or exposed through at least a portion of a surface of the fabric or substrate, as a plurality of lines or dots in a specific pattern that positions the metal particles in discrete electrically isolated locations separated by a distance, wherein the fabric or substrate is configured such that said metal particles contact a skin surface of the human or animal, wherein the plurality of spaced lines are substantially evenly spaced from one other; and a layer adapted to hold a substance; wherein said fabric or substrate forms a plurality of half-cells of an air-metal battery, for ion exchange with the skin of the human or animal whereupon a substance located between the device and the skin is driven in by iontophoresis.
Patent WO-2019245837-A1 (WO)
Title: Système de déplacement pour véhicule omnidirectionnel
Inventor: BARTLETT GLYNN
IPC: B66F9/075
Filed: 2019-06-13
Abstract: Un système de déplacement omnidirectionnel comprend un châssis avec un axe central s'étendant d'une première extrémité à une seconde extrémité; un support s'étendant de la première extrémité à la seconde extrémité; un premier ensemble de roues Mecanum reliées par l'intermédiaire d'un premier essieu et reliées au châssis ; un second ensemble de roues Mecanum reliées par l'intermédiaire d'un second essieu et reliées au châssis ; et un système de suspension souple reliant le châssis au support.
Patent WO-2019246205-A1 (WO)
Inventor: KREISLER KEVIN
IPC: C01G23/04
Filed: 2019-06-19
Abstract: Exciton scavenger devices can be designed to absorb broadband or narrowband radiation and convert this radiation into electricity. A system for powering of electronic devices by one or more exciton scavenger device(s) is described.
Patent WO-2019246502-A1 (WO)
Title: Dispositif de stockage
Inventor: SNEDDON BRIAN MATTHEW
IPC: B65D6/26
Filed: 2019-06-21
Abstract: Un dispositif de stockage comprend une base, et un certain nombre de panneaux latéraux couplés sélectivement à la base. Chacun des panneaux latéraux comprend une partie saillante. La base comprend un certain nombre de vides définis dans celle-ci. Les parties saillantes, une fois insérées dans les vides, limitent le mouvement des panneaux latéraux par rapport à la base dans au moins deux directions de coordonnées.
Patent WO-2020005880-A1 (WO)
Title: Enabling 5g nr non-standalone e-utran dual-connectivity via dual-connectivity roaming
Inventor: STAUFFER ERIK RICHARD
IPC: H04W8/12
Filed: 2019-06-25
Abstract: The present disclosure describes techniques and systems for enabling fifth generation new radio (5G NR) non-standalone (NSA) evolved universal terrestrial radio access network new radio dual-connectivity (EN-DC) via dual-connectivity roaming. These techniques enable a user device (110) connected to a first service-provider network (602) to dual-connectivity roam onto a second service-provider network (604). The user device (110) can access the second service-provider network (604) ( e.g.,  to support EN-DC in a non-overlapping area of the first service-provider network) while using an anchor link of the first service-provider network (602). In one example, a user device (110) on a Long Term Evolution (LTE) service-provider network (602) can dual-connectivity roam onto a 5G NR service-provider network (604) while using an anchor link of the LTE service-provider network (602) to access the second 5G NR service-provider network (604) and communicate using EN-DC.
Patent WO-2020027966-A1 (WO)
Title: Continuous lead strip casting line, caster, and nozzle
Inventor: ROMEO MICHAEL
IPC: B21B1/00
Filed: 2019-07-01
Abstract: In one embodiment, a lead strip caster for battery grids includes a nozzle, a pair of rollers, and a molten lead supply to the nozzle. The lead strip caster produces a continuous lead strip for making battery grids. The nozzle has at least one passage that communicates with generally opposed faces of the nozzle at least partially received between the rollers to supply molten lead to exterior surfaces of the co-rotating rollers to form a continuous solid strip of lead from which battery grids may be made.
Patent WO-2021010984-A1 (WO)
Inventor: WELSCHER MARKUS
IPC: G02C7/06
Filed: 2019-07-16
Abstract: A bifocal spectacle lens (1) and a method for creating a numerical representation of a bifocal spectacle lens (1) are made available. The bifocal spectacle lens (1) comprises a distance portion (3), a near portion (5) and a transition section (7) situated between the distance portion (3) and the near portion (5). The distance portion (3) is optimized in view of optical power for distance vision and the near portion (5) is optimized in view of optical power for near vision. The transition section (7) is determined in such a way that the latter creates a continuous transition between the distance portion (3) and the near portion (5). The distance portion (3) and the near portion (5) are optimized independently of one another and put together with the transition section (7) to form the numerical representation of the bifocal spectacle lens (1, 10, 20).
Patent WO-2020033240-A1 (WO)
Title: Method of screening skin products
Inventor: WEI KARL
IPC: G01N33/569
Filed: 2019-08-02
Abstract: A method evaluating a skin cleansing composition for an ability to treat a skin condition, can include a) identifying a target skin condition or lack of target skin condition on a skin sample; b) taking a baseline measurement of a Microbial index of Skin Health via a Microbial index of Skin Health Method; c) performing a wash protocol with the cleansing composition via the Wash Protocol Method; and d) taking a second measurement of the Microbial Skin Health Measurement after the Wash Protocol; wherein an increase from the baseline Microbial Skin Health Index of 5 or more signifies the cleansing product is efficacious for treatment of the identified skin condition.
Patent WO-2020033308-A1 (WO)
Title: Timeout for provisional response ack to reduce voip call setup time
Inventor: GEORGE ANISH
IPC: H04L29/06
Filed: 2019-08-05
Abstract: Embodiments of a User Equipment (UE) and methods of communication are generally described herein. The UE may receive, from a RAN node, an INVITE message that indicates an incoming VoIP call for the UE. The UE may transmit, to the RAN node, a provisional response message to acknowledge the INVITE message. The UE may monitor for a provisional response acknowledgement (PRACK) message in accordance with a provisional acknowledgement timer. The UE may determine a provisional acknowledgement timeout value used to determine expiration of a provisional acknowledgement timer. The value of the provisional acknowledgement timeout value may be determined to be a value that is less than a default session initiation protocol (SIP) timeout value.
Patent WO-2020036855-A1 (WO)
Title: System, method and computer-accessible medium for tissue fingerprinting
Inventor: GEETHANATH SAIRAM
IPC: A61B5/055
Filed: 2019-08-12
Abstract: Exemplary system, method, and computer-accessible medium for generating a magnetic resonance (MR) tissue fingerprint training network(s) can be provided, using which it is possible to, for example, receive first information related to a MR image(s) of a portion(s) of a phantom(s), partition the first information into a plurality of patches, and generate the MR tissue fingerprint training network(s) by applying a convolutional neural network(s) to the patches. The convolutional neural network(s) can be a fully convolutional neural network(s). Each of the patches can be a same size. The patches can be overlapping patches. A size of the patches can be 3x3 pixels. The MR tissue fingerprint training network can be generated based on float values for each of the patches.
Patent WO-2020106351-A1 (WO)
Title: Increasing gene expression
Inventor: CHEN CI-DI
IPC: C12N15/87
Filed: 2019-09-06
Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. In certain examples, the present disclosure provides a method of increasing expression of a Klotho gene in a cell the method comprising administering to the cell a binding molecule that binds to an RNA transcript transcribed from a chromosomal region within or near the Klotho gene, wherein the RNA transcript does not encode a Klotho protein.
Patent WO-2020051464-A1 (WO)
Title: Eyecups for optics
Inventor: KUCZEK ANDRZEJ
IPC: G02B23/16
Filed: 2019-09-06
Abstract: An eyecup (100) for an optic includes an elastic body (101) forming an eye receiver (103) and a viewing cavity (105), the elastic body configured to move between a relaxed state (fig 1) and a compressed state (fig 3); and a diaphragm (107) formed from or attached to an inner surface (109) of the elastic body, the diaphragm including one or more flaps (111) configured to be in a closed position when the elastic body is in the relaxed state such that the one or more flaps block sight of an optic through the viewing cavity, and to be in an open position when the elastic body is in the compressed state such that the one or more flaps allow sight of an optic through the viewing cavity and one or more magnets (113) are sensed by one or more sensors (115) to activate an optic display (501).
Patent WO-2020051498-A1 (WO)
Inventor: BALKOVEC JAMES
IPC: A61K39/00
Filed: 2019-09-06
Abstract: L'invention concerne des compositions et des procédés pour le traitement d'infections virales, qui comprennent des conjugués contenant des inhibiteurs de la neuraminidase virale (par exemple, zanamivir, peramivir ou des analogues de ceux-ci) liés à un monomère Fc, un domaine Fc et un peptide de liaison à Fc, une protéine d'albumine ou un peptide de liaison à l'albumine. En particulier, les conjugués peuvent être utilisés dans le traitement d'infections virales (par exemple, des infections virales de la grippe).
Patent WO-2020060780-A1 (WO)
Inventor: ALBERT DAVID E
IPC: A61B5/00
Filed: 2019-09-06
Abstract: Described herein are devices, systems, and methods for sensing and generating a one or more of the 12 leads of a standard ECG with a mobile computing device. In some embodiments, three electrodes are positioned on a mobile computing device so that an individual may comfortably contact all three sensors at once to generate a six lead ECG which may be displayed on a display of said mobile computing device. In some embodiments, analysis carried out further comprises determining a QRS axis and QRST angle.
Patent WO-2020214201-A1 (WO)
Inventor: NARASIMHAN SRINIVASA
IPC: G01V8/02
Filed: 2019-09-25
Abstract: A method to dynamically and adaptively sample the depths of a scene using the principle of triangulation light curtains is described. The approach directly detects the presence or absence of obstacles (or scene points) at specified 3D lines in a scene by sampling the scene. The scene can be sampled sparsely, non-uniformly, or densely at specified regions. The depth sampling can be varied in real-time, enabling quick object discovery or detailed exploration of areas of interest. Once an object is discovered in the scene, adaptive light curtains comprising dense sampling of a region of the scene containing the object, can be used to better define the position, shape and size of the discovered object.
Patent WO-2020068926-A1 (WO)
Title: A heat resistant textile sleeve and a method of making the heat resistant textile sleeve
Inventor: FUKUYAMA SHOZO
IPC: C03C25/1095
Filed: 2019-09-25
Abstract: A textile sleeve for protecting an elongated member comprises a tubular body, made from a woven or braided fiberglass yam, having an inner surface and an outer surface. A coating adheres to the outer surface providing heat resistance to said tubular body. The coating is a silicone rubber containing phenyl partially disposed therein. According to one aspect, the silicone rubber is a phenyl containing polysiloxane. According to another aspect, the silicone rubber has a formula of R-SiO 3/2  wherein R includes phenyl and oxygen or R consists of phenyl and oxygen. The tubular body has a heat resistance of at least 550°C. A method of making the textile sleeve is also disclosed herein.
Patent WO-2020068992-A1 (WO)
Inventor: KULPA DEANNA ALENE
IPC: G01N33/569
Filed: 2019-09-25
Abstract: L'invention concerne des compositions et des méthodes pour quantifier le nombre de cellules Infectées de manière latente par le VIH dans un échantillon. La présente invention concerne des compositions et des méthodes pour détecter le VIH réplicatif.
Patent WO-2020073035-A1 (WO)
Title: Preparation of ion exchange membranes from polyolefins and polycyclic olefins
Inventor: BAE CHULSUNG
IPC: B01D61/44
Filed: 2019-10-07
Abstract: Ion exchange membranes for use in electrochemical energy conversion and storage applications include copolymers having a backbone produced from an olefin, such as ethylene, and a cyclic olefin, such as norbomene. Haloalkyl side chains with terminal halide groups are connected to the polymer backbone via Friedel-Crafts alkylation. The halide groups are then replaced with ionic groups via substitution. The ion exchange membrane material can then be cast or impregnated into a reinforcing mesh to form cation exchange membrane or anion exchange membranes. Rigidity of the ion exchange membranes can be controlled by varying the ratio of olefin to cyclic olefin in the polymer backbone.
Patent WO-2020093028-A1 (WO)
Inventor: PRUCHA CHRISTOPHER
IPC: B29C70/64
Filed: 2019-11-01
Abstract: Système de fabrication additive comprenant un ensemble base et un ensemble plateau. L'ensemble base comprend une fenêtre de construction, sensiblement transparente au rayonnement électromagnétique ; un système de projection conçu pour projeter un rayonnement électromagnétique vers une surface supérieure de la fenêtre de construction ; et un siège de plateau disposé autour d'un périmètre de la fenêtre de construction. L'ensemble plateau est conçu pour venir en prise avec l'ensemble base dans une configuration en prise et comprend : une structure de plateau délimitant un élément d'alignement conçu pour venir en prise avec le siège de plateau afin de positionner une ouverture proximale à la surface supérieure de la fenêtre de construction dans la configuration en prise ; et une membrane de séparation qui est conçue pour stratification à travers la surface supérieure de la fenêtre de construction en réponse à une évacuation de gaz d'une région interstitielle et conçue pour se séparer de la fenêtre de construction en réponse à l'injection de gaz dans la région interstitielle.
Patent WO-2020097587-A1 (WO)
Inventor: DAY VIVIANNA
IPC: G01N30/72
Filed: 2019-11-09
Abstract: The present disclosure describes a method, a system, and a computer program product of indicating a status of an analytical instrument on a screen of the analytical instrument. In an embodiment, the method, the system, and the computer program product include receiving data from an analytical instrument monitoring a liquid sample, segmenting the received data into data segments for at least two characteristics of at least one of the instrument, the sample, and an operating environment of the instrument, analyzing each of the data segments for the at least two characteristics, retrieving threshold values for the at least two characteristics from a computer data source, calculating at least one status of at least one of the instrument, the sample, and the operating environment, with respect to the analyzed data segments and the threshold values, and displaying the at least one status on a display of the instrument.
Patent WO-2020113093-A1 (WO)
Inventor: ACKERMAN THOMAS
IPC: B05B7/06
Filed: 2019-11-27
Abstract: L'invention concerne un pulvérisateur électrostatique (10, 70) qui peut fonctionner à des débits élevés et à des pressions basses particulièrement appropriées pour le séchage par pulvérisation. Le pulvérisateur (10, 70) comprend un corps allongé (12) ayant un ensemble buse de pulvérisation aval (14, 71) à travers lequel un liquide chargé électriquement est dirigé par l'intermédiaire d'un tube d'alimentation central (18) à l'intérieur du corps de buse (12) et l'air d'atomisation est fourni par l'intermédiaire d'un passage annulaire (25) autour du tube d'alimentation en liquide (18). Dans un mode de réalisation, l'ensemble buse est un ensemble buse de pulvérisation de tête de grappe de mélange externe (14) ayant une pluralité de pointes de pulvérisation métalliques espacées sur la circonférence (40). Dans un autre mode de réalisation, la buse de pulvérisation est un ensemble buse de mélange interne (71) ayant une pointe de pulvérisation (71) comprenant une chambre de mélange interne (72a) pour pulvériser un liquide avant la décharge.
Patent WO-2020146346-A1 (WO)
Title: Ear tip sealing structure
Inventor: ZALISK MICHAEL ANDREW
IPC: H04R1/10
Filed: 2020-01-07
Abstract: Aspects describe an earpiece with structure for positioning and retaining the earpiece and with structure for sealing against the entrance to the ear canal. According to aspects, the retaining structure has at least one substantially elliptical leg configured to follow the curve of the anti-helix and/or the cymba concha at the rear of the concha. The leg increases in thickness from a tip of the earpiece towards the body of the earpiece. The sealing structure is substantially frusto-conical and extends from a nozzle. The nozzle is angled to align with ear geometry. In an example, the sealing structure has a slight radius on an outer surface of the sealing structure. In another example, the sealing structure has a substantially constant thickness from the nozzle to the wide end of the sealing structure.