baber/WOPTO huggingface dataset:
Patent UY-33016-A (UY)
Title: Los compuestos y metodos para la modulacion de cinasas, e instrucciones para los mismos
Inventor: JIAZHONG ZHANG
IPC: A61K31/437
Filed: 2010-11-08
Abstract: Se describen compuestos y sales, formulaciones, conjugados, derivados, formas y usos. Los compuestos descritos o sales, conjugados, derivados, formas, activos sobre proteína cinasa Fms, o sobre proteína cinasa Fms y Kit, o sobre proteína cinasa Fms y Flt-3. se describen metodos para tratar enfermedades, asociado con la actividad de cinasa Fms, cinasa Kit, o cinasa Flt-3, artritis reumatoide, osteoartritis, esclerosis múltiple, Alzheimer, Parkinson, glomerulonefritis, nefritis intersticial, nefritis por Lupus, necrosis tubular, nefropatía diabética, hipertrofia renal, leucemia mieloide aguda, melanoma, mieloma múltiple, cáncer de mama metastático, cáncer de próstata, cáncer pancreático, neurofibromatosis de cerebro, y tumores de estoma gastrointestinal.
Patent UY-35269-A (UY)
Title: ?dispositivo para siembra acoplable a pulverizadora autopropulsada?.
Inventor: LUIS MATONTE SAID JOSÉ
IPC: A01C7/08
Filed: 2014-01-16
Abstract: La invención se refiere a un dispositivo de siembra que se acopla fácilmente a una pulverizadora autopropulsada y es también fácilmente removido para volver a utilizar la pulverizadora como fumigadora. Dicho dispositivo incluye una tolva incorporada a una estructura de fijación (2), conectada a una caja dosificadora de semillas (4) donde se mezcla el aire con las semillas, y la corriente es transportada hacia cabezales de distribución (12a, 12b)  que se fijan en los brazos de la pulverizadora autopropulsada. Cada cabezal se une a caños (14) que a su vez se unen a boquillas esparcidoras (15).
Patent UY-35315-A (UY)
Title: Anticuerpos anti-il-17a y su uso en el tratamiento de trastornos autoinmunes e inflamatorios
Inventor: THOMAS HUBER
IPC: C12P21/08
Filed: 2014-02-07
Abstract: La presente descripción se refiere a los anticuerpos y las proteínas que comprenden unaparte de unión a antígeno de los mismos que se unen específicamente a IL-17A de citoquinas pro-inflamatorias. La descripción se refiere más específicamente a los anticuerpos y proteínas específicas que son antagonistas de la IL-17A (inhibir las actividades de IL-17A e IL-17AF) y son capaces de inhibir la producción de citoquinas inducida por IL-17A en ensayos in vitro, y que tienen un efecto inhibidor en un modelo de artritis inducida por antígeno in vivo. La descripción se refiere además a composiciones y métodos de uso de dichos anticuerpos y proteínas para el tratamiento de trastornos patológicos que se pueden tratar mediante la inhibición de la actividad mediada por IL-17A o IL17AF, tales como artritis reumatoide, psoriasis, lupus eritematoso sistémico (SLE), nefritis lúpica, enfermedad pulmonar obstructiva crónica, asma o fibrosis quística u otras enfermedades autoinmunes e inflamatorias.
Patent UY-39290-A (UY)
Title: Un método para disminuir la inmunogenicidad de un fragmento de anticuerpo que comprende una cadena ligera variable y/o una cadena pesada variable
Inventor: GUNDE TEA
IPC: C07K16/46
Filed: 2010-12-22
Abstract: Se da a conocer un método para disminuir la inmunogenicidad de los dominios variables de un anticuerpo
Patent BE-798362-A (BE)
Title: 1,3-disubstd-3-aroylpropanes - analgesics, antiarrythmics and cns depressants
Inventor: MANGHISI E
IPC: C07D211/52
Filed: 1973-04-17
Abstract: Compounds of formula (I) (where Ar= aryl opt. substd. by one or more halo; polyhaloalkyl or lower alkoxy; R'= OH, acyloxy, carbamoyloxy, alkyl- or dialkyl-carbamoyloxy, aroyloxy, alkoxy, aryloxy or CN, or the residue of an opt. substd. secondary, tert. or heterocyclic amine; and -NR2R3 is the residue of an opt. substd. secondary, tert. or heterocyclic amine) and pharmaceutically acceptable acid addn. salts thereof in racemic or optically active forms. (I) and their salts are analgesics, antiarrhythmics and CNS depressants. (HNR4R5 is an opt. substd. secondary, tert. or heterocyclic amine). (F) When R'=CN.
Patent BE-902937-A (BE)
Title: Perfectionnements aux sacs filtrants.
IPC: B01D29/27
Filed: 1985-07-19
Abstract: Le sac filtrant est formé d'un panneau comprenant deux parties de largeurs différentes, ces largeurs étant telles que lorsque le panneau est plié suivant une ligne de pliage (4) les deux parties forment un panneau à deux plis présentant un coté dépassant (9). Le coté (9) est replié suivant une deuxième ligne de pliage sur le coté libre du pli (2). Les cotés précités et le pli le plus large sont fixés ensemble par une couture de surjet (13) de façon qu'il soit formé un tube (12). L'invention concerne aussi un procédé de fabrication du sac filtrant.
Patent CA-1080847-A (CA)
Inventor: KOSONOCKY WALTER F
IPC: H01L21/339
Filed: 1971-12-09
Granted: 1980-07-01
Abstract: Abstract Charge coupled circuits which may be arranged in arrays and interconnected to form long registers of either the open-ended or the circulating type.  Features of these circuits include new electrode structures which permit close spacing between electrodes, self-alignment of electrodes of very small size and which may be layed out to achieve high packing density.  They also permit two or higher numbers of voltage phases to be employed for unidirectional charge signal propagation.  The circuits also include improved structures including a floating junction for coupling one register to another for charge regeneration and for reset purposes.  Biasing arrangements are employed for optimizing the amount of charge to be propagated and for providing potential wells of a contour to insure unidirectional signal propagation.  Additional features of a circuit are discussed in detail below.
Patent CA-1038105-A (CA)
Inventor: MACDONALD RICHARD C
IPC: A61F13/15
Filed: 1973-12-06
Granted: 1978-09-12
Abstract: ABSTRACT           An absorbent pad particularly useful in the manu-facture of disposable diapers, comprising wood fibers that are stabilized within the pad by means of a plurality of filaments incorporated into the pad with a network of adhesive bonds such that the fibers within the pad are prevented from shifting from location to location within the pad.  By reason of this stabili-zation of the fibers within the pad, there is prevented the slumping and/or lumpiness heretofore experienced in such pads that are not stabilized.
Patent CA-1039445-A (CA)
Inventor: TAKIMOTO YASUYUKI
IPC: B41C3/06
Filed: 1974-04-05
Granted: 1978-09-26
Abstract: Abstract of the Disclosure A plastic printing or duplicating plate is produced in the form of a sheet of syndiotactic 1,2-polybutadiene or a mixture with a compatible thermoplastic resin, preferably a polyolefin. This can be produced from a mold in the form of a novel matrix having a relief pattern thereon transferred from an original. The novel matrix can be in the form of a sheet of syndiotactic 1,2-polybutadiene, or a flong with a surface coating of syndiotactic 1,2-polybutadiene or a flong coated with a thermosetting silicone resin varnish.
Patent CA-1044867-A (CA)
Inventor: DE SMEDT FELIX F
IPC: B29B7/00
Filed: 1974-06-12
Granted: 1978-12-26
Abstract: Abstract The production of extruded polymeric film is hampered by the defect known as "die lines". In accordance with the present invention, the effect rather than the cause of the defect is removed, by passing the extruded film with its opposite faces in succession over two smooth cooling surfaces. The film faces which are brought into contact with the corresponding cooling surfaces are in a substantially molten condition and they are electrostatically pinned to said cooling surfaces.
Patent CA-1045721-A (CA)
Inventor: LONGMAN MILLARD D JR
IPC: G06G7/625
Filed: 1974-08-19
Granted: 1979-01-02
Abstract: ABSTRACT OF THE INVENTION      Method for designing an integrating circuit having a finite memory such that an accurate average of events over a time period just ended can be obtained without having events occurring previous to the time period affecting the resultant data, and the circuit obtained.  A polynomial expression is formed by taking a continued fraction expansion of the Laplace transformation expression                       where T is a predetermined period of time.  The polynomial is solved using Bessel's coefficient equation and expressed as an approxi-mate transfer function of the desired circuit response.  Net-work synthesis techniques are applied to the approximate transfer function to design the approximately ideal integrator circuit.
Patent CA-1047648-A (CA)
Inventor: MINAMI SHUNJI
IPC: H03K4/00
Filed: 1975-03-27
Granted: 1979-01-30
Abstract: ABSTRACT OF THE DISCLOSURE          A voltage memory device is disclosed wherein the gate of a MOS field-effect transistor is connected to one terminal of a capacitor and to an input voltage terminal through an input resistor and through the contacts of a reed relay while the source is connected to an output terminal and an output resistor, the input resistor being inserted in order to determine the charging time of the capacitor.  When the reed relay is actuated, the capacitor is charged or dis-charged depending upon whether the input voltage terminal is connected to a positive or negative voltage supply source so that the output voltage increases or decreases.  When the reed relay is de-energized, the output voltage remains at the same level.  The voltage memory device has a function similar to that of the conventional variable resistors, but it eliminates the use of any sliding part and is operable at a relatively low voltage in a reliable  and dependable manner.  The voltage memory may be used in an automatic control system.
Patent CA-1058738-A (CA)
Inventor: BRIGGS HAROLD A
IPC: H02H3/08
Filed: 1975-05-23
Granted: 1979-07-17
Abstract: ABSTRACT OF THE DISCLOSURE             A current transformer used in a power circuit for initi-ating operation of a circuit breaker has a resistor in series with the burden on its secondary.  This resistor is shunted by a set of contacts which close or open with the main contacts of the breaker. These secondary con-tacts are closed when the main contacts are closed and are open only when the main contacts are open.  Opening of the secondary contacts places the resistor in series with the burden; this causes repid decay of the flux in the core to the residual level, rapidly making the trans-former ready for further fault current when the main breaker contacts are reclosed.  This arrangement will improve the transient performance of current transformers, but it is particularly effective with gapped core current trans-formers.
Patent CA-1055921-A (CA)
Inventor: BURTON VANCE P
IPC: B01J38/56
Filed: 1975-05-27
Granted: 1979-06-05
Abstract: ABSTRACT      A method for the restoration of porosity and catalytic activity to a catalyst bed composed of a mass of solid particles, where the catalyst bed has been deactivated and occluded by the deposition of carbonized and polymerized hydrocarbons.  The catalyst is repeatedly washed, at superatmospheric conditions of temperature and pressure, with a liquid phase hydrocarbon mixture containing aromatic hydrocarbon species. Deactivating materials are dissoved within the hydrocarbon mixture and are removed from the catalyst bed when washing mixture is withdrawn.
Patent CA-1049435-A (CA)
Inventor: IRWIN ROY E
IPC: C10G73/36
Filed: 1975-06-16
Granted: 1979-02-27
Abstract: ABSTRACT     The deoiling of slack wax or similar wax composition is accomplished while the wax is confined in cells provided by a series of plates which are spaced apart by only 1/16 to 1/2 inch and which are vertically or otherwise disposed for drain-age along the surfaces thereof from an upper margin to a lower margin.  The plates are traversed by a multiplicity of conduits for a temperature-controlling fluid such as water.  During the treatment the lower melting point constituents of the confined wax composition become progressively melted responsive to gra-dual increments of temperature increase and drain transversly along the plates through a distance which is from about 4 to 24 inches and preferably is of the order of 6 to 12 inches so as to become separated from the residual end product wax.  The deoiling thus accomplished is much more effective and more rapid as compared with sweating procedures.  It compares favorably in these respects to deoiling by solvent extraction.  The instal-lation cost of this process is a fraction of the cost of conven-tional solvent deoiling.
Patent CA-1052171-A (CA)
Inventor: JAPIKSE CORNELIS H
IPC: A23L2/40
Filed: 1975-06-17
Granted: 1979-04-10
Abstract: Abstract of the Invention A process for preparing an extremely rapidly dis-solvable dry beverage mix by admixing the beverage flavor base with the beverage sugar content to form a slurry having a high total solids content and drying the slurry.
Patent CA-1048272-A (CA)
Inventor: GARNER EUGENE F
IPC: B60R21/26
Filed: 1975-07-23
Granted: 1979-02-13
Abstract: ABSTRACT Of THE DISCLOSURE This pyrotechnic composition is adapted, upon combustion, for generating a low flame temperature, non-toxic gas for inflating a vehicle safety bag or other inflatable device. The composition comprises:  a fuel, such as a carbonaceous material, aluminum or magnesium, an inorganic oxidizer, such as a metal chlorates a metal perchlorate, a metal nitrate, ammonium chlorate, ammonium perchlorate or ammonium nitrate; and a coolant or combined binder and coolant, such as magnesium carbonate, magnesium hydroxide or a mixture of magnesium hydroxide and magnesium carbonate.  A typical example of this composition comprises:  carbon as the fuel; potassium chlorate as the oxidizer; and magnesium carbonate or a mixture of magnesium hydroxide and magnesium carbonate as the binder-coolant.  One may use as much of this later mentioned binder-coolant as is necessary to obtain the desired binding properties in the composition, without raising the flame temperature of the gas to an unacceptable level.
Patent CA-1075696-A (CA)
Inventor: TAYLOR HAROLD M
IPC: C07D213/62
Filed: 1975-08-22
Granted: 1980-04-15
Abstract: Abstract of the Disclosure A class of novel 3-phenyl-4(IH)-pyridones and pyridinethiones which are broad-spectrum herbicides are described herein.  The new compounds are characterized by a small substituent on the nitrogen, and usually bear a 5-substituent chosen from a class described herein.  The phenyl ring may be substituted.  The compounds are effective herbicides when applied both before and after the emergence of weeds, and are particularly useful for the control of weeds in cotton cropland.
Patent CA-1040623-A (CA)
Inventor: IMMER HANS U
IPC: C07K14/655
Filed: 1975-08-28
Granted: 1978-10-17
Abstract: DERIVATIVES OF RETRO-ENANTIO-SOMATOSTATlN.         INTERMEDIATES THEREFOR,AND PROCESS THEREFOR     Abstract of the Disclosure Compounds of the formula I or Ia   (I.)   (Ia.) in which R is hydrogen or CONHCH2CONHCH2CH3 are disclosed.  The compounds are obtained by a process which comprises the following step: preparing peptide fragments II, III, V and VII see below, by a series of condensations involving the reaction of an appropriately protected peptide having an activated ester group with an appropriately protected peptide having a free amino group; condensing    (II) by means of the azide method with            (III) followed by hydrogenolysis of the reaction product to obtain                       (IV), condensing the latter by means of the azide method with               (V) followed by treating the resulting compound with hydrazine hydrate to obtain   (VI), condensing the latter by means of the azide method with HNH?HCH2STrt (VII) in which R is hydrogen or CONHCH2CONHCH2CH3 to obtain the linear protected peptide       (VIII) in which R is as defined herein; thereafter said linear peptide is transformed into the desired cyclic peptide of formula I by deprotecting and oxidizing processes.  In addition, the linear, reduced form of the peptide of formula Ia is obtained by deprotection of the aforementioned linear peptide or by reduction of the cyclic peptide.  The peptides of formulae I and Ia are useful for the management of diabetes and the treatment of acromegaly.  Methods for their use are also disclosed.
Patent CA-1065096-A (CA)
Inventor: MALOFSKY BERNARD M
IPC: C08F299/00
Filed: 1975-09-30
Granted: 1979-10-23
Abstract: ABSTRACT OF THE DISCLOSURE         Adhesive and sealant compositions are described having improved strength properties at elevated temperatures and improved resistance to thermal degradation.  The composition comprises a mixture of an acrylate or methacrylate monomers polymerizable by free-radical initiation or anaerobic composition and an additive selected from:
Patent CA-1050312-A (CA)
Inventor: ANDERSON RAYMOND H
IPC: G03B27/54
Filed: 1976-03-02
Granted: 1979-03-13
Abstract: ABSTRACT       A compact portable overhead projector providing improved uniformity and efficiency of illumination employs an off-focus light source within a truncated light-diffusing ellipsoidal reflector in conjunction with an off-focus aperture plate adjacent the open end of the reflector.
Patent CA-1039994-A (CA)
Inventor: BARTH GUENTER
IPC: E01C5/00
Filed: 1976-04-05
Granted: 1978-10-10
Abstract: IMPROVEMENTS IN OR RELATING TO SLAB-ELEMENTS FOR   COVERING THE GROUND            ABSTRACT OF THE DISCLOSURE         A slab element for covering the ground is made e.g. of concrete and forms as a single piece.   It has a head portion and a stem portion meeting at a notional meeting surface.   The element is delimited by two opposite end faces of equal length joined by sides that form angled traces about a longitudinal axis common to the head at the stem, each said angled trace being formed by a succession of sides comprising at said head an inclined side face inclined in one direction relatively to the axis, a lateral side face extending lengthwise with respect to the axis and another inclined side face inclined in the opposite direction with respect to the axis, and comprising at the stem a lateral side face extending lengthwise with respect to the axis which is complementary to the lateral face of the head, the end face of the head together with its inclined sides and its lateral faces and the meeting surface describing a centrally symmetrical octagon, and the meeting surface together with the end face and lateral faces of the stem being symmetrical about the centre of the stem.  The head may describe a regular octagon.   The stem may describe a square.   But the stem may also describe a circle.   The elements can be laid to form a composite ground covering structure, laid e.g. in herringbone bond pattern, and laid e.g. to include one or more supplementing slab elements of the same peripheral configuration as the stems of the elements.
Patent CA-1050423-A (CA)
Inventor: BRINTON CHARLES C
IPC: C12Q1/12
Filed: 1976-04-23
Granted: 1979-03-13
Abstract: GONOCOCCAL PILI PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE DETECTION   OF AND PREVENTION OF INFECTIONS CAUSED BY    NEISSERIA GONORRHOEAE                          CHARLES C. BRINTON  JOHN  McMICHAEL                     ABSTRACT OF THE DISCLOSURE            There are provided a crystalline and single rod produces derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoeae organisms.  There are provided methods of growing said organisms to produce the maximum yield of Pili and procedures for purifying said Pili to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorrhoeae organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili.  There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization to infection by N. gonorrhoeae in mammalian systems susceptible to such infection.
Patent CA-1064944-A (CA)
Inventor: BULTEAU GERARD
IPC: C07D207/09
Filed: 1976-06-09
Granted: 1979-10-23
Abstract: ABSTRACT OF THE DISCLOSURE         There is provided a novel process for preparing the N-(1ethyl-2-pyrrolidylmethyl)-2-methoxy-5-sulphamoyl benzamide by the selective reduction of the tertiary amide group of N-(1-acetyl-2-pyrrolidylmethyl)-2-methoxy-5-sulphamoyl benzamide. The product obtained is a useful antiemetic.
Patent CA-1089276-A (CA)
Title: Hybrid liquid toners including an amphipathic polymer,  a charge director, a thermoplastic fixer and a dispersant
Inventor: KOSEL GEORGE E
IPC: G03G9/12
Filed: 1976-11-01
Granted: 1980-11-11
Abstract: Abstract of the Disclosure A hybrid liquid toner composed of a mixture of two different types of liquid toner.  One type is a liquid toner that includes a complex amphipathic molecule of which at least a fixer and a dispersant are polymeric moieties and which additionally includes a charge director and optionally includes a color agent, all of these being carried by a volatile organic solvent of high electrical resistivity.  The other type of liquid toner is one that includes a fixer and a dispersant as separate chemical entities and further includes a charge director, a pigment type color agent and a carrier solvent such as mentioned above.  The two toners can be mixed in a very wide range of proportions and when so mixed have several advantages which makes -the hybrid toner particularly useful in connection with preparation of lithographic masters and microfiche reproductions by electrostatography as well as useful as an all purpose liquid toner.
Patent CA-1055054-A (CA)
Inventor: FOSTER BRUCE C R
IPC: E21C25/34
Filed: 1976-11-30
Granted: 1979-05-22
Abstract: ABSTRACT OF THE DISCLOSURE     For a mining machine, a cutter chain link has at least one pick box disposed symetrically with respect to a longitudinal central plane of the link.  A pair of forward coupling members and a rear coupling member on the link each have a link pin receiving bore, the long-itudinal central plane being perpendicular to these bores.  The new coupling member is receivable between the forward coupling members of a like link for coupling thereto by a link pin.  A pick receiving bore extends completely through the pick box for holding a pick with one end of the pick abutting the rear coupling member, the axis of the pick receiving bore being inclined towards the rear end of the link and intersecting the rear link receiving bore axis.
Patent CA-1051314-A (CA)
Inventor: FUKUI KIYOZUMI
IPC: F03C1/00
Filed: 1976-12-17
Granted: 1979-03-27
Abstract: Abstract of the Disclosure A drive controlling mechanism comprises in combina-tion:  a hydraulic motor including a cylinder block, and a rotary shaft cxtending axially of and positioned within the cylinder block to be engaged with the cylinder block for rotation therewith; a motor housing for accommodating therein the hydraulic motor; a control block securely connected with the motor housing and rotatably receiving one end portion of the rotary shaft; a parking brake arrangement detachably received within the axially outer half of the control block for being capable of braking the rotary shaft; a control valve arrangement detachably mounted on the outer peripheral wall of the control block in fluidal communica-tion with the parking brake arrangement by way of a shuttle valve accommodated in a radial bore formed in the control block so that the hydraulic motor is controlled to be driven by the control valve arrangement; and a pair of inlet-outlet conduits for introducing a pressure oil to the control valve arrangement and discharging the pressure oil from the control valve arrangement.