baber/WOPTO huggingface dataset:
Patent DE-69435260-D1 (DE)
Inventor: CRABTREE GERALD R
IPC: C10G7/06
Filed: 1994-02-14
Granted: 2010-02-11
Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the ¶ chain of the T cell receptor (TCR)-CD3 complex thereby leading to signaling and transcription of a reporter gene, (2) the homodimerization of the cytoplasmic tail of the Fas receptor thereby leading to cell-specific apoptosis (programmed cell death) and (3) the heterodimerization of a DNA-binding domain (Gal4) and a transcription-activation domain (VP16) thereby leading to direct transcription of a reporter gene.  Regulated intracellular protein association with our cell permeable, synthetic ligands offers new capabilities in biological research and medicine, in particular, in gene therapy. Using gene transfer techniques to introduce our artificial receptors, one can turn on or off the signaling pathways that lead to the overexpression of therapeutic proteins by administering orally active "dimerizers" or "de-dimerizers", respectively. Since cells from different recipients can be configured to have the pathway overexpress different therapeutic proteins for use in a variety of disorders, the dimerizers have the potential to serve as "universal drugs". They can also be viewed as cell permeable, organic replacements for therapeutic antisense agents or for proteins that would otherwise require intravenous injection or intracellular expression (e.g., the LDL receptor or the CFTR protein).
Patent DE-69518510-D1 (DE)
Inventor: KOIVU VESA
IPC: H04L1/00
Filed: 1995-03-27
Granted: 2000-09-28
Abstract: PCT No. PCT/FI95/00164 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 27, 1995 PCT Pub. No. WO95/26602 PCT Pub. Date Oct. 5, 1995A method for decoding information in a telecommunication network, in which the information frames are received, the data is buffered, decoded and a parity check is made. Before transmitting the data further in the transmission network an additional check is made. Depending on the outcome of the parity check and the additional check the frames to be transmitted further in the network are marked as faultless or defective. The result of the additional check is established from the processing of earlier received data.
Patent DE-69523663-D1 (DE)
Inventor: HAEMAELAEINEN JARI
IPC: H04B7/26
Filed: 1995-05-03
Granted: 2001-12-13
Abstract: The invention relates to a system for transmitting packet data in the air interface of a digital cellular system based on TDMA, Time Division Multiple Access. The mobile terminated logical channels comprise information channels designated for transmitting information and control channels, which can be a fast paging (FP) channel and an acknowledgement (A) channel. The mobile originated logical channels comprise information channels designated for transmitting information and a reservation (R) channel, whereon the mobile station requests the system to reserve a connection for transmitting packet data. According to the invention, for the TDMA frames there is allocated a variable number of time slots for packet transmission, taking into account the symmetricity/asymmetricity of the packet transmission, as well as the total packet transmission demand of the cell. For fast paging (FP), acknowledgement (A) and reservation (R), there can be employed any of the time slots in the frame allocated for packet transmission. It is advantageous that in each time slot, the subscriber's data is subjected to the same interleaving and forward error coding algorithm, so that the respective time slots of consecutive frames form independent logical sub-channels, which are then reserved for one subscriber according to the needs, and to which the subscriber's data is multiplexed at the beginning of the transmission, and wherefrom it is again demultiplexed after the transmission. <IMAGE>
Patent DE-69609912-D1 (DE)
Inventor: YOSHIDA AKIRA
IPC: C07C255/01
Filed: 1996-09-18
Granted: 2000-09-28
Abstract: Compounds of formula (I): <CHEM> wherein: R<1> is alkyl; R<2a>, R<2b>, R<2c> and R<2d> are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R<3> is alkyl; R<4> is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): <CHEM> wherein: A<1> is a single bond, alkylene or alkenylene; A<2> is or alkenylene; A<3> is a single bond, alkyleneor alkenylene; R<5a> and R<5b> are the same or different and each is hydrogen, alkyl or various other groups; R<6> is alkyl or phenyl; R<7> is hydrogen or alkyl; R<8> is alkyl or various other groups; and n is 0 or 1Ü and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.
Patent DE-69611184-D1 (DE)
Inventor: SCHER BENSON
IPC: A01N25/28
Filed: 1996-06-03
Granted: 2001-01-11
Abstract: Solid water-dispersible compositions containing microencapsulated pesticides are produced by spray-drying an aqueous suspension of said pesticides in the presence of a water-soluble polymer.
Patent DE-69611443-D1 (DE)
Inventor: STUDER MARTIN
IPC: C07C303/40
Filed: 1996-05-07
Granted: 2001-02-08
Abstract: PCT No. PCT/EP96/01889 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/36597 PCT Pub. Date Nov. 21, 1996One object of the invention is a process for the catalytic hydrogenation of aromatic nitro compounds in solution or in melt in the presence of hydrogen and at least one noble metal catalyst, nickel catalyst or cobalt catalyst, in which process a catalytic amount of at least one vanadium compound is present, wherein the vanadium has the oxidation state 0, II, IV or V. It has been found that in the catalytic hydrogenation of aromatic nitro compounds the accumulation of hydroxylamines can be almost completely prevented by the addition of catalytic amounts of vanadium compounds, which usually results in concentrations of <1% hydroxylamine. The resulting hydrogenated products are whiter (purer) than those obtained without the addition of the vanadium compound because almost no azo or azoxy compounds are obtained. The hydrogenation, in particular the final phase, proceeds faster than without said addition. Accordingly, substantial advantages with respect to quality constancy and economy are obtained.
Patent DE-69620821-D1 (DE)
Inventor: VAN HALL MAURICE
IPC: A62B25/00
Filed: 1996-06-07
Granted: 2002-05-29
Abstract: A harness to enable the wearer to carry an article such as breathing apparatus comprises a waist belt (9) carrying a waist plate (1) to which a back plate (21) is secured. The harness includes shoulder straps (20) and a means (41,50) of securing the article to it. The back plate (21) is moveable with respect to the waist plate (1) to facilitate movement of the wearer's body. <IMAGE>
Patent DE-69625808-D1 (DE)
Inventor: LAUNIEMI MARKKU
IPC: E21B19/24
Filed: 1996-04-18
Granted: 2003-02-20
Abstract: The arrangement comprises a pressure medium cylinder (2) provided with two cylinder spaces (2a, 2b) and two pistons (3a, 3b), and a control valve (12). The control valve (12) can be placed in at least three control positions but in only one at a time. In each control position, the pressure fluid is arranged to affect both cylinder spaces (2a, 2b) of the cylinder (2) such that in the control position concerned, the pistons (3a, 3b) always settle in a certain predefined position.
Patent DE-69628387-D1 (DE)
Inventor: BARTHELEMY PIERRE
IPC: C08G18/16
Filed: 1996-09-17
Granted: 2003-07-03
Abstract: Pre-mixt. comprises: (a) polyol(s); (b) 1,1,1,3,3-pentafluorobutane as swelling cpd.; and (c) a catalyst contg. cpd(s). for the catalysis of polyol/isocyanate reaction and opt. a cpd. other than a metal alkali carboxylate or hydroxyalkyl ammonium carboxylate for the catalysis of the trimerisation of the isocyanates. Also claimed are: (i) the prepn. of the polyurethane or modified polyurethane foams; and (ii) polyurethane or modified polyurethane foams.
Patent DE-69633398-D1 (DE)
Inventor: LEE KUO-HSIUNG
IPC: A61K45/06
Filed: 1996-06-05
Granted: 2004-10-21
Abstract: Betulinic acid derivs. of formula (I) and (II) are new. In (I) the dotted line is a double bond; in (II) the dotted line is a single bond; R = opt. substd. 2-20C mono- or di-carboxyacyl; and R' = H, opt. substd. 2-20C alkyl, or aryl. Also claimed is a compsn. contg. (I) or (II), or their esters, salts, ethers, sulphates or glucuronides, and an anti-viral agent or an immunostimulating agent.
Patent DE-69635740-D1 (DE)
Inventor: PLOWMAN D
IPC: C12N15/12
Filed: 1996-11-25
Granted: 2006-04-06
Abstract: The present invention relates to AUR-1 and/or AUR-2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR-1 and/or AUR-2 related diseases or conditions characterized by an abnormal interaction between an AUR-1 and/or AUR-2 polypeptide and an AUR-1 and/or AUR-2 binding partner.
Patent DE-69701301-D1 (DE)
Inventor: GALEY JEAN-BAPTISTE
IPC: A61K8/00
Filed: 1997-06-18
Granted: 2000-03-23
Abstract: Substituted benzyl derivatives of polyalkylene-polyamines of formula (I) and their salts and metal complexes are new. n, m = 2-4; p = 2 or 3; x = 0-2; R1, R4 = 1-4C alkyl; or a group of formula (a); Z1 = OH or OR; Z2, Z3 = H, OH or OR; R = 1-8C alkyl; R2, R3 = H, 1-4C alkyl, (a) or R5R5'N(CH2)p; R1', R4', R5' = H or 1-4C alkyl; and R5 = 1-4C alkyl or (a); provided that: (1) at least one of R1-R5 = (a) and (2) when R1=R4 = (a) and x = 0 or 1, then Z1 or Z1 and Z2 are not OR'; R' = 1-6C alkyl.
Patent DE-69701958-D1 (DE)
Inventor: VALISKO STEVEN
IPC: F01N3/34
Filed: 1997-01-10
Granted: 2000-06-15
Abstract: PCT No. PCT/GB97/00081 Sec. 371 Date Jul. 10, 1998 Sec. 102(e) Date Jul. 10, 1998 PCT Filed Jan. 10, 1997 PCT Pub. No. WO97/25526 PCT Pub. Date Jul. 17, 1997An exhaust manifold device is provided to allow air to enter an exhaust manifold during normal operation of an engine to prevent exhaust gases being sucked into the cylinders via exhaust valves. Air can be supplied via valves (18 and 21) to the exhaust manifold as required and is supplied to the valve (21) at pressures, above atmospheric pressure, that increase with engine speed.
Patent DE-69707886-D1 (DE)
Inventor: PIRIM PATRICK
IPC: G06T7/20
Filed: 1997-07-22
Granted: 2001-12-06
Abstract: A process and a device operating in real time for identifying and localizing an area in relative movement in a scene and determining the speed and oriented direction of the relative movement in real time. The process carries out temporal processing of a digital video input signal S(PI) that includes deducing, from the variations between the value of each pixel in a frame and in the immediately preceding frame, a binary signal DP identifying whether or not there was a significant variation and a digital signal CO representing the magnitude of this variation, and a spatial processing including distributing in a matrix these two signals successively for a single frame that is scanned through the matrix, and deducing the required relative movement and its parameters from this matrix distribution. The device includes a temporal processing unit associated with a memory and a spatial processing unit associated with a delay unit, a clock unit and control unit to control the rate of operation of the temporal and spatial processing units.
Patent DE-69711635-D1 (DE)
Inventor: BOHIN FABRICE
IPC: C09D183/04
Filed: 1997-07-03
Granted: 2002-05-08
Abstract: A silicone composition and the uses thereof, particularly as a coating on an airbag for protecting the occupant of a vehicle in the event of a collision, are disclosed. The aim is to provide a silicone composition suitable for coating onto the inner surface of the airbag while significantly reducing the weight of the resulting coating layer to form a protective coating having enhanced high-temperature, mechanical and substrate-adhesion properties. Said aim is achieved in that the composition is free of reinforcing mineral fillers and consists of a mixture of (1) at least one polyorganosiloxane with alkenyl groups bound to the silicon; (2) at least one polyorganosiloxane with hydrogen atoms bound to the silicon; (3) a cross-linking catalyst; (4) an adhesion promoter comprising (4.1) at least one alkoxylated organosilane, (4.2) at least one epoxy-functional organosilicon compound, and (4.3) at least one metal chelate and/or metal alkoxide wherein the metal is selected from the group which consists of Ti, Zr, Ge, Li, Mn, Fe, Al and Mg; (5) at least one polyorganosiloxane resin; and (6) optionally at least one cross-linking inhibitor.
Patent DE-69715610-D1 (DE)
Inventor: GRIFOLL CASANOVA JUAN
IPC: G01R31/26
Filed: 1997-10-13
Granted: 2002-10-24
Abstract: Plant for obtaining sheets with optical effects, said sheets (2) receiving the impression of various patterns and/or illustrations (a, b, c, d and e) and receiving a layer of transparent resin (1); the engraving of the resin, by contact and polymerisation, produces the optical effects. In the plant, the application of the resin (1) to the sheet (2) is effected by rotogravure, rotary serigraphy, flexography, offset or other means, directly to the engraving cylinder (4, 4', 4'' or 4''') or on the sheet (2); ultra violet rays (18) are used as polymerising element, optatively with filter (19) for infrared rays, or an electron generator; the engraving and polymerization of the resin (1) are done at the same time and with the use of an engraver cylinder (4, 4', 4'', or 4''') without any seam. The printing means, the engraving means and the polymerization means form a compact assembly (20) arranged in line on a rotary machine (21). <IMAGE>   <IMAGE>
Patent DE-69717621-D1 (DE)
Inventor: KNUTSON H
IPC: B01D29/15
Filed: 1997-04-28
Granted: 2003-01-16
Abstract: Apparatus and for the treatment of storm water runoff to remove contaminants that accumulate in the storm water when it flows over paved surfaces in urban areas. The apparatus includes a basket that has an outer surrounding water-permeable wall, and an inner water-permeable wall, spaced from and surrounded by the outer wall. A bed of an absorbent, able to absorb contaminants in the storm water, is disposed in the space between the outer and inner walls, while allowing fluid communication between the walls. An inner drainage space is defined by the inner wall and is in fluid communication with the absorbent. During operation, storm water flows through the outer permeable wall, into the bed where it is treated; and treated water flows from the bed through the inner wall into the inner drainage space. Treated water then flows from the drainage space, in some embodiments under a siphon-effect, into a treated water drainage conduit for disposal. The absorbent may be selected from compost, vermiculite, activated carbon, peat, ion exchangers, clays, and the like, and may be in the form of pellets or particulates. The baskets are of modular construction so that the beds are in containers that may be removed and replaced, with minimal labor. Moreover, the baskets may be backflushed to remove particulates and debris that clog the beds and retard the treatment rate.
Patent DE-69720064-D1 (DE)
Inventor: APERIA ANITA CHATARINA
IPC: A61P13/12
Filed: 1997-12-19
Granted: 2003-04-24
Abstract: The invention is related to the use of COMT inhibitors in the treatment of diabetic vasculat dyfunctions.
Patent DE-69722198-D1 (DE)
Inventor: TUOMIKOSKI PEKKA
IPC: F16G13/02
Filed: 1997-04-25
Granted: 2003-06-26
Abstract: Method for chain drive, whereby the chain, such as a transmission chain, conveyor chain and/or like, is formed of several shaped pieces (1), that are connected to each other one after another at jointing points (N) by means of joint pins, and that is being driven by means of a wheel arrangement, that includes at least one chain wheel (7), such as a drive wheel, a turning wheel or the like. Particularly wearing of the chain, that is due to bending of the chain essentially along the longitudinal direction (p) of the joint pins, is being minimized by taking advantage of joint pins (x), the cross section of which changes in the longitudinal direction (p). The invention also relates to chain functioning according to the method.
Patent DE-69726513-D1 (DE)
Inventor: PALKOWITZ ALAN DAVID
IPC: A61P3/06
Filed: 1997-08-27
Granted: 2004-01-15
Abstract: The instant invention provides novel benzoÄbÜthiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. The novel benzoÄbÜ thiophenes have the formula <CHEM>  wherein   R<1> is -H, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -O(CO)OAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R<2> is -H, -F, -Cl, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -O(CO)OAr where Ar is phenyl or substitutedphenyl,-OCO(C1-C6 alkyl),-O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R<3> and R<4> are, independently, -H, -F, -Cl, -CH3,-OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl), with the proviso that R<3> and R<4> are not both hydrogen;   n is 2 or 3; and R<5> is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof.
Patent DE-69727061-D1 (DE)
Inventor: LAGERSTROEM GUNNAR
IPC: H04J14/00
Filed: 1997-09-11
Granted: 2004-02-05
Abstract: The present invention relates to an optical system with an optical amplifier having at least one input and output, a control circuit for controlling the output power of the amplifier with the aid of an output process demand signal (PD) from a control means. The control circuit comprises control means, a detector block and a means for tapping off light from an input or an output of the optical amplifier to the detector block. According to the invention, at least one check signal (A) is disposed to be sent in at least one check signal channel which passes through the optical amplifier. The detector block is configured to measure the amplitude of the control signal(s).
Patent DE-69728887-D1 (DE)
Inventor: HOLMAN JOHN
IPC: C07D487/04
Filed: 1997-08-13
Granted: 2004-06-03
Abstract: An improved process for the preparation of 1,2,4-triazolo[1,5-a]pyrimidine compounds comprising the reaction involving a compound of formula IIand a compound of formula IIIin the presence of an oxidizing agent and a reducing agent, wherein a metal salt is added to form a complex with the oxidized reducing agent produced in the process, and this complex is separated from the desired product.
Patent DE-69801011-D1 (DE)
Inventor: VILLERMET ALAIN
IPC: B01F23/10
Filed: 1998-01-09
Granted: 2001-08-09
Abstract: The process forms a gaseous mixture of predetermined composition, containing a carrier gas, oxidant and silane. A primary gas mixture is formed from a second neutral gas and the silane. The silane content is below the spontaneous flammability limit of silane in air. A first gas stream is prepared, comprising carrier gas with controlled oxidant gas residual. The required mixture is achieved as a function of the residual oxidant content in the carrier gas stream.   Also claimed are: (i) the plant for the above process; and (ii) gaseous mixtures formed by the above process.
Patent DE-69808958-D1 (DE)
Inventor: RICKARD PAUL
IPC: H04B3/54
Filed: 1998-06-08
Granted: 2002-11-28
Abstract: A power line communications system comprises a power line (120) for distributing electricity to a plurality of premises (S1, S2...) and communication stations (TRX) coupled to the power line at the premises. Data is transmitted to/from stations over the power line using a packet data communications protocol. Apparatus at premises can convert signals between a first protocol, used on the power line, and a second protocol e.g. Ethernet for transferring data to a communications station.
Patent DE-69902830-D1 (DE)
Inventor: MIYOSHI KEISUKE
IPC: F16H59/10
Filed: 1999-02-09
Granted: 2002-10-17
Abstract: A shifting arrangement for an automatic transmission with manual gear shift feature has a control member (203) which is operative to connect and disconnect operational linkage between a shift lever (3,21) and a shift cable (26) connected to a manual valve (301) in a hydraulic control circuit. The control member is supported to slide relatively to the shift lever when the shift lever moves laterally as it is operated between automatic driving positions (P,R,N,D) including an automatic gear shift selecting position (D) so that the shift lever remains operationally connected to the shift cable. The control member (203) is coupled to the shift lever when the shift lever is operated from the automatic gear shift selecting position (D) to a manual gear shift selecting position (M) so that the control member moves laterally into an opening (240) and out of contact with portions (27,28) of a bracket (13) connected to the shift cable, thereby to operationally disconnect the shift lever from the shift cable. <IMAGE>
Patent DE-69903462-D1 (DE)
Inventor: NOELLE FREDERIC
IPC: D04H1/74
Filed: 1999-06-15
Granted: 2002-11-14
Abstract: The invention concerns a method which consists in continuously: producing by carding (1) a web (10 from chemical fibers; subjecting the resulting web (1) to a hydro-entanglement using water jets, treatment which consists in: (a) consolidating the web (10) by the action of a first series of water jets (3), the web (10) being supported by a drum (4) comprising micro-perforations; (b) subjecting the consolidated web (10) to structuring, by the action of one or several series of water jets (12); depositing on the surface of the resulting structured lap (10a) natural fibers (14) by pneumatic layering (6); subjecting the resulting complex (20) to the action of another series of water jets (7) acting on the surface covered with natural fibers.
Patent DE-69906357-D1 (DE)
Inventor: LONARDI EMILE
IPC: C21B7/20
Filed: 1999-10-05
Granted: 2003-04-30
Abstract: The invention concerns a device for dispensing bulk materials comprising a vertical rotor (22) wherein is suspended a chute (14) so as to pivot about a substantially horizontal pin (26). A guiding device (68i, 70i) interlocked in rotation with the rotor (22), is connected between the rotor (22) and a first ring (66), so that the latter can axially slide along the rotor (22). Connecting rods (73, 73') transform a vertical sliding of the first ring (66) causing the chute (14) to pivot. A roller ring (76) connects the first ring (66) to a second ring (74), whereto are connected control means, for example a lever actuated by a hydraulic actuator (80), capable of varying the vertical position of the two rings (66, 74) and the chute (14) inclination.