Patent SG-11201408173W-A (SG)
Title: Pyrimidinyl tyrosine kinase inhibitors
Inventor: HOPKINS BRIAN T
IPC: A61K31/435
Filed: 2013-06-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2013/185084 A1 12 December 2013 (12.12.2013) WIPO I PCT (51) International Patent Classification: A01N 43/40 (2006.01) A61K31/445 (2006.01) A61K31/435 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/044800 7 June 2013 (07.06.2013) English English (30) Priority Data: 61/657,360 8 June 2012 (08.06.2012) US (71) Applicants: BIOGEN IDEC MA INC. [US/US]; 133 Bo­ ston Post Road, Weston, Massachusetts 02493 (US). SUN- ESIS PHARMACEUTICALS, INC. [US/US]; 395 Oyster Point Boulevard, Suite 400, South San Francisco, California 94080 (US). (72) Inventors: HOPKINS, Brian T.; 169 Washington Street, Apt. 13, Newton, Massachusetts 02458 (US). CONLON, Patrick; 20 Eaton Street, Wakefield, Massachusetts 01880 (US). CHAN, Timothy R .; 53 Bennington Street, Newton, Massachusetts 02458 (US). JENKINS, Tracy J.; 44 Vin­ cent Avenue, Belmont, Massachusetts 02478 (US). CAI, Xiongwei; c/o BIOGEN IDEC MA INC., 133 Boston Post Road, Weston, Massachusetts 02493 (US). HUMORA, Michael; c/o BIOGEN IDEC MA INC., 133 Boston Post Road, Weston, Massachusetts 02493 (US). SHI, Xianglin; c/o BIOGEN IDEC MA INC., 133 Boston Post Road, We­ ston, Massachusetts 02493 (US). MILLER, Ross A.; 3001 Hadley Road, Suite 1-4, South Plainfield, New Jersey 07080 (US). THOMPSON, Andrew; 3001 Hadley Road, Suite 1-4, South Plainfield, New Jersey 07080 (US). (74) Agents: REARICK, John P. et al.; Choate, Hall & Stew­ art LLP, Two International Place, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) •t 00 o 00 i-H o CJ (54) Title: PYRIMIDINYL TYROSINE KINASE INHIBITORS (57) Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyr­ osine kinase and which exhibit desirable characteristics for the same.