baber/WOPTO huggingface dataset:
Patent CA-2570893-A1 (CA)
Inventor: TUCKER HOWARD
IPC: A61K31/4523
Filed: 2005-06-20
Abstract: Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).
Patent CA-2571049-A1 (CA)
Title: Retinal derivatives and methods for the use thereof for the treatment of visual disorders
Inventor: PALCZEWSKI KRZYSZTOF
IPC: A61K31/225
Filed: 2005-06-20
Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
Patent CA-2573245-A1 (CA)
Inventor: KONRADI ANDREI W
IPC: A61K47/48
Filed: 2005-07-08
Abstract: Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Patent CA-2576452-A1 (CA)
Title: A method and nodes for optimized and secure communication between routers and hosts
Inventor: WASSIM HADDAD
IPC: H04L9/32
Filed: 2007-01-30
Abstract: A method, a router and a host are introduced for providing secure communication with limited use of processing intensive cryptographic means. Strong cryptographic keys are first used between the host and the router to sign messages therebetween, thereby ensuring that a first communication between the host and the router is secure. The router generates a secret key and forwards it to the host, the secret key being encrypted at the router and decrypted at the host by use of the strong cryptographic keys. Further communication between the host and the router is signed by use of the secret key.
Patent CA-2576600-A1 (CA)
Title: Water drain tank or channel module
Inventor: WHITTEMORE MICHAEL R
IPC: E03B3/00
Filed: 2007-02-01
Abstract: A water drain tank or channel module (10) includes a structure having a top platen (20) and a bottom platen (22), a plurality of generally vertical support members (26) for supporting at least the top platen (20), the support members (26) being retained in sockets (28) on at least one of the bottom platen (22) and the top platen (26), and optional side walls (19) each including a water--permeable lattice member (24) that is adapted to support an impermeable membrane (32) or water--permeable geotextile material (30) that is capable of controlling the flow of drain water at least out of the module (10) and restricting sediment from entering the module (10). An assembly (11) of such modules (10, 10', 10", 10a, 10b, 10c, 10d) to form a drain tank, channel or storage reservoir is also disclosed.
Patent CA-2576709-A1 (CA)
Title: Procede de fabrication de piece de turbomachine comportant des orifices d'evacuation d'air de refroidissement
Inventor: ALAUX THIERRY
IPC: F01D5/18
Filed: 2007-01-26
Abstract: La présente invention porte sur un procédé de réalisation d'orifices d'évacuation de fluide de refroidissement dans la paroi (171) d'une pièce fabriquée selon la technique de la fonderie à la cire perdue avec formation d'un modèle dans un moule à cire, les orifices comportant une première portion (110 E) débouchant à la surface externe (171 ext) de la paroi. Le procédé est caractérisé par le fait qu'il consiste à ménager dans le modèle en cire des cavités correspondant aux premières portions (110 E) desdits orifices de la pièce. On permet ainsi la réalisation d'orifices d'évacuation d'air de refroidissement sans arêtes vives.
Patent CA-2577546-A1 (CA)
Inventor: KALAFSKY ROBERT E
IPC: A61K8/893
Filed: 2005-08-16
Abstract: A novel combination of silicon resin, amorphous silica and low oil absorbing spherical powder is described which when added to topical skin care compositions containing high concentrations of active agents, improves their aesthetic feel and ease of application.
Patent CA-2580442-A1 (CA)
Inventor: JUCH MATHIAS
IPC: G01N35/00
Filed: 2005-10-25
Abstract: A central unit (1) with reaction vessels includes a conveying unit (6) carrying reaction vessels and an analytical unit (7, 8). The central unit also has a sample-taking unit (30) transferring a portion from the sample vessel into a reaction vessel. Reaction vessels are carried by the conveying unit to analytical units. Reaction vessels (20-23) are provided with reagent(s) for reaction with the samples. A measurement device (5) and measurement instruments quantify physical properties of the sample. The measurement device (5) is contained in the central unit, where ion-selective electrolyte measurement is carried out and the required reagents are prepared, in the central unit itself. The measurement instruments are contained in the analytical unit (7, 8). Reagents are prepared in the analytical unit for supply to the samples, followed by measurement-taking. The reagents are contained in individual vessels or magazines containing reagent vessels. The latter have a self-dispensing capability for each reagent vessel. The reaction vessels are disposable. The conveying unit operates in one direction only, from the central unit to one of the analytical units. In the central unit a separator prepares individual reaction vessels All vessels can be identified e.g. by single- or multidimensional bar codes, other optical methods, transponders or marking molecules in the fluid. Further equipment in the analytical units identifies the vessels. Additional facilities provided in the analytical system include: temperature control, water supply, mixing, vessel cleaning, pipetting and sample-pretreatment.
Patent CA-2580798-A1 (CA)
Inventor: SEMB HENRIK
IPC: A61K35/12
Filed: 2005-09-29
Abstract: The present invention relates to methods for obtaining endodermal progenitor cells and further differentiating these to hepatocyte-like cells. Knowledge about the cell composition prior to the initiation of terminal differentiation is used to select one of two different protocols and one of two type of intermediate progenitors depending on the purpose for which the resulting hepatocyte-like cells are needed. Protocol A of the present invention relates to differentiation of extraembryonic-resembling endodermal progenitor cells to hepatocyte-like cells and may be selected when yield and purity of the obtained hepatocyte-like cells is important. Protocol B of the present invention relates to differentiation of mesendodermal-resembling progenitor cells to hepatocyte-like cells and may be selected when quality of the obtained hepatocyte-like cells is important.
Patent CA-2583969-A1 (CA)
Inventor: ROCHE GLENN
IPC: B65C9/18
Filed: 2005-10-13
Abstract: A flexible magnetised portion applicator is disclosed. The apparatus applies a portion of flexible self-adhesive magnetised material (31) onto a card that is typically promotional in nature, for it to be held magnetically against a metal surface, via the method of pulling the magnetised material's adhesive release-coated backing paper (28) between rollers that grip the material (25) and (26), which when correctly rotated, draw suitably wide, adhesive-backed magnetised material (12) from a roll (13) into the apparatus (11) to project the material (28 )over a stationary lower blade (18) and then cut a portion via a shear action (30) between a descending upper blade (19) mounted on a linear actuating ram (21) and the stationary lower blade (18), to then carry via the magnetism possessed within each portion (32) and press-apply (36) the self-adhesive portion of magnetised material (31) onto the upper-most card in a stack of cards (35) residing beneath the apparatus positioned to receive the said portion.
Patent CA-2583970-A1 (CA)
Title: Pipe coupling and male coupling member
Inventor: MATSUMOTO KOJI
IPC: F16L37/46
Filed: 2005-10-12
Abstract: A pipe joint, comprising a male joint. The male joint is selectively connectable to a first female joint (for example, for 25 MPa) or a second female joint (for 90 MPa) which handle different fluid pressures and capable of preventing a second O-ring set for the second female joint from being displaced by a fluid supplied from the first female joint when the male joint is connected to the first female joint. An O-ring holding member (82) displaceable between an advanced position (Fig. 3) where the second O-ring (78) is prevented from being displaced by the fluid flowing from the first female joint through a through hole when the O-ring holding member is located on the radial inner side of the second O-ring (78) and connected to the first female joint (20') and a retreated position (Fig. 1) where the O-ring holding member is displaced backward by the tip of the valve element (44) of the second female joint when connected to the second female joint (20) and the tip outer peripheral surface of the valve element is sealingly engaged with the second O-ring is installed in the through hole (70).
Patent CA-2585618-A1 (CA)
Title: Method and apparatus for generating equalizer filter tap coefficients
Inventor: PIETRASKI PHILIP J
IPC: H03H7/30
Filed: 2005-10-18
Abstract: A method and apparatus generating an error signal (156) and an update vector signal (124) used to generate filter tap coefficients (128) for an equalizer filter (130) residing in an equalizer (100). The equalizer filter (130) outputs an equalized signal (132) in response to receiving a sample data stream (102). The error signal (156) is generated by down-sampling (140) the equalized signal (132), subtracting (144) the equalized signal (132) from a reference signal (146) and filtering (150) and down-sampling (154) the resulting signal. Simultaneously, the update vector signal (124) is generated by converting scalar samples of the sample data stream (102) to a data vector signal (106) and descrambling 116, filtering (118), and down-sampling (122) the data vector signal (106). A tap coefficients generator (126) is used to generate the filter tap coefficients (128) for updating the equalizer filter (130) based on the error signal (156) and the update vector signal (124).
Patent CA-2587887-A1 (CA)
Inventor: KEPPEL PAUL D
IPC: F01N13/02
Filed: 2005-10-14
Abstract: An arcing electron stream apparatus and method for reducing pollutants in a fluid. The device includes first and second electrodes and a chamber there-between. Voltage is impressed between the electrodes at a frequency, thereby causing a plurality of arcing electron streams to occur between the electrodes. The electrodes have stepped surface such that the central first section of the electrodes are in closer proximity to each other than are the outer second sections. This stepped configuration causes arcing electron streams to progressively be formed along the electrodes and, thus, traverse throughout the chamber, thereby effectively treating molecules within the chamber.
Patent CA-2589754-A1 (CA)
Inventor: SUBIK JULIUS
IPC: C12N15/81
Filed: 2005-11-25
Abstract: The present invention provides modified yeast cell lines and their use in screening procedures for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype. It is especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of resistance-relevant genes. The invention further provides methods for constructing said cell lines and their use in screening systems.
Patent CA-2589881-A1 (CA)
Inventor: KE TIANYI
IPC: A61K39/385
Filed: 2005-12-02
Abstract: Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosentizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce6-DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.
Patent CA-2590451-A1 (CA)
Title: Hanger mounts for child swing
Inventor: TUCKEY PETER R
IPC: A63G9/16
Filed: 2005-11-25
Abstract: An attachment apparatus provides a quick connection of the hanger tubes for a child~s swing seat assembly to the pivot member of a drive mechanism powering the reciprocal movement of the seat assembly. The shape of the mating attachment members, including a rounded for a swing seat assembly that can be accomplished simply by sliding the hanger tubes over or into the mating receptacles . A quick disconnect device engages automatically and provides a secure connection between the hanger tube and the receptacle. Removal of the seat assembly requires only a release of the quick disconnect device and a lifting of the seat assembly from the frame apparatus. In one embodiment the linear side portions are angled into a wedge-shape to ensure proper seating and driving connection to transmit torque to the hanger tubes.
Patent CA-2595691-A1 (CA)
Title: Treatment of alkylation catalyst poisons
Inventor: BETBEZE MICHAEL
IPC: C07C15/073
Filed: 2006-02-15
Abstract: Alkylation processes are described herein. The alkylation process generally includes contacting an input stream including benzene with an alkylation catalyst and an alkylating agent to form an alkylation output stream including ethylbenzene. The alkylation process further includes contacting at least a portion of the alkylation output stream with a transalkylation catalyst and a benzene source to form a transalkylation output stream, wherein the benzene source is selected to minimize the amount of alkylation catalyst poisons contacting the alkylation catalyst.
Patent CA-2597074-A1 (CA)
Inventor: TENNY NATHAN E
IPC: H04W72/02
Filed: 2006-02-08
Abstract: Methods, systems and apparatus for dispersing a group of user equipment (UEs) concentrated on a single channel is disclosed. After receiving a disperse command the UEs select a channel, and then select a cell. The channel selection may be performed using a random or pseudorandom function. The cell selection may be performed prior to camping on the cell. Prior to camping the UEs may test the acceptability of a candidate cell and/or may perform a cell reselection. The result of the dispersion is that the UEs are distributed amongst many channels (a, b, c, and d), where reference are found in Figures 1A and 1B.
Patent CA-2598579-A1 (CA)
Inventor: FISCHER ANDREAS
IPC: C07C217/54
Filed: 2006-02-21
Abstract: This invention relates to solid crystalline forms of (1 RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1 ,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
Patent CA-2598684-A1 (CA)
Title: Porcine helicobacter infection
Inventor: FLORES JOEL
IPC: A61K39/02
Filed: 2006-02-23
Abstract: Compositions and methods for treating, preventing and diagnosing Helicobacter infection are disclosed. The methods use proteins and/or nucleic acids derived from Helicobacter cerdo, a new pathogen isolated from swine. In addition, porcine models for studying bacterial gastritis and gastric and duodenal ulcer disease caused by Helicobacter pathogens, such as H. pylori and H. cerdo are described, as well as methods of identifying vaccines and compounds for treating and/or preventing Helicobacter infection using the animal models.  Also described are methods of preventing Helicobacter infection in swine, such as infection caused by H. cerdo, using immunogenic proteins and nucleic acids derived from Helicobacter pathogens, such as H. pylori.
Patent CA-2598807-A1 (CA)
Inventor: JACOBS MERRIT
IPC: G01N1/38
Filed: 2007-08-17
Abstract: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
Patent CA-2601062-A1 (CA)
Inventor: VUNNUM SURESH
IPC: A01H1/00
Filed: 2006-03-10
Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
Patent CA-2603832-A1 (CA)
Title: Flow path conditioner system
Inventor: GILLIGAN THOMAS BOYD
IPC: C11D1/14
Filed: 2006-04-06
Abstract: Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.
Patent CA-2608753-A1 (CA)
Inventor: JONES JEFFREY W
IPC: A61C15/00
Filed: 2006-05-18
Abstract: A device includes a handle coupled with an activated textured surface that can be implemented using a repetitive movement mechanism and a treatment energy source, such as an electromagnetic radiation source. The handle may be used to provide detection, treatment and/or management of sundry conditions including, for example, tooth discoloration, tissue damage, periodontal disease, tumors, pain, halitosis, and bronchitis. The activated textured surface may include a surface topography including corrugations, bristles, protuberances, or pits, or other surfaces for facilitating agitation, cleaning or other surface treatments.
Patent CA-2609255-A1 (CA)
Title: Intermediate in production of [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound
Inventor: NAITO TOSHIHIKO
IPC: C07C275/32
Filed: 2006-05-25
Abstract: A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. [Chemical formulae] wherein R1 and R2 independently represent a hydrogen atom or an amino-protecting group for an amino group, or R1 and R2 may together form a pyrrole ring which may have a substituent.
Patent CA-2610551-A1 (CA)
Inventor: SYLVESTER JEFFREY S
IPC: A01K63/04
Filed: 2007-11-15
Abstract: A liquid container aeration system for replenishing gases dissolved in a selected liquid present in an interior of said liquid container that checks on an electrical power source capability to continue operation and allows selected liquid substitution in the interior of the container.
Patent CA-2612562-A1 (CA)
Inventor: CURTI JAMES N
IPC: A61M15/08
Filed: 2006-06-16
Abstract: A method of forming a cannula from a cannula mandrel assembly comprising a pair of mouthpiece/nasal mandrels and a mating facepiece mandrel. The facepiece mandrel has a pair of conical holes, in an intermediate section thereof, for receiving a leading end of one mouthpiece/nasal mandrel. The conical holes allow the facepiece mandrel to slide along the mouthpiece/nasal mandrels until the conical holes abut with respective mating tapering conical sections and prevent further sliding movement along the mouthpiece/nasal mandrels. Following assembly, the assembly is heated, at least one coating of a polymeric material is applied thereto and heat from the assembly at least partially cures the polymeric material on the assembly. Following curing, the facepiece mandrel and formed cannula are slide along the mouthpiece/nasal mandrels until the facepiece mandrel and formed cannula are removed therefrom.  Lastly, the facepiece mandrel is removed from the formed cannula.
Patent CA-2613672-A1 (CA)
Title: Method of driving liquid crystal display device
Inventor: MOCHIZUKI AKIHIRO
IPC: G09G3/36
Filed: 2006-06-28
Abstract: A method of driving a liquid crystal device that comprises at least a pair of substrates and a liquid crystal material disposed between the pair of substrates. A voltage increase rate to be attained during the duration of a voltage pulse applied to the liquid crystal device is changed in order to continuously control the quantity of light transmitted by the liquid crystal device, whereby shades are displayed.
Patent CA-2617627-A1 (CA)
Title: Oxygen indicator for use in medical products
Inventor: MELIN CHRISTIAN
IPC: G01N31/22
Filed: 2006-08-02
Abstract: An oxygen indicator is provided for revealing the presence of oxygen in a container housing a medical formulation. The indicator can be formulated with components deemed safe for use with medical products. A preferred oxygen indicator can withstand heat sterilization and prolonged storage and can provide a distinct and marked color change to indicate oxygen is present.  Preferably, the indicator can be manufactured in its oxidized form and reduced upon steam sterilization. Additionally, both the color of the reduced form and the color of the oxidized form should not fade or significantly change during storage. Moreover, once a color change has occurred indicating the presence of oxygen, the oxidized color preferably remains substantially unchanged visually to the observer even after prolonged storage. The oxygen indicator can be housed in a polymeric pouch or packet having a transparent portion for viewing the color of the indicator.
Patent CA-2618084-A1 (CA)
Title: Microparticle compositions of the topoisomerase i inhibitor 7-tert-butoxyiminomethylcamptothecin
Inventor: TAILLARDAT AGNES
IPC: A61K9/107
Filed: 2006-08-08
Abstract: The present invention relates to microparticle pharmaceutical compositions in which the active agent is a topoisomerase I inhibitor, in particular, 7-f-butoxyiminomethylcamptothecin, that is useful for the treatment and prevention of proliferative diseases including cancer.
Patent CA-2618931-A1 (CA)
Inventor: MAKHIJA SURENDER
IPC: H02J7/02
Filed: 2008-01-23
Abstract: A system and method of dynamically charging a lead-acid battery that has been in a deep discharged state for an extended period of time or is deeply sulfated includes an alternating current (AC) line input connected to a transformer. The output of the transformer is connected to a pair of silicon-controlled rectifiers (SCRs). The SCRs are in turn connected to terminals of a lead-acid battery. A pair of signal diodes is used to obtain waveform information for the AC input for phase control to trigger the SCRs. The outputs of the signal diodes and the SCRs are connected to a phase regulated output controller. A turn-on time for the SCRs is delayed to create a differential voltage between the transformer output and a voltage of the battery. The differential voltage is applied to terminals of the battery at an increased frequency rate to break battery sulfation.