Patent SG-11201901137U-A (SG)
Title: Silk-derived protein for treating inflammation
Inventor: LAWRENCE BRIAN D
IPC: C07K14/435
Filed: 2017-08-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property --11` . 1#11101111 0 11101 HOE 3E1 0 0111E011H MO Ell 0011110 1111 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ..../.- WO 2018/031973 Al 15 February 2018 (15.02.2018) WIPOIPCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61F 2/14 (2006.01) A61K 47/42 (2017.01) kind of national protection available): AE, AG, AL, AM, A61K 38/17 (2006.01) CO7K 14/435 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/046659 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 12 August 2017 (12.08.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/374,532 12 August 2016 (12.08.2016) US kind of regional protection available): ARIPO (BW, GH, 62/407,863 13 October 2016 (13.10.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/467,697 06 March 2017 (06.03.2017) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: SILK TECHNOLOGIES, LTD. [US/US]; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 3700 Annapolis Ln N, Ste 105, Plymouth, Minnesota 55447 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: LAWRENCE, Brian D.; 51 Sandpiper Road, KM, ML, MR, NE, SN, TD, TG). _ Tampa, Florida 33609 (US). INFANGER, David W.; 6236 = Troy Lane North, Maple Grove, Minnesota 55311 (US). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) = (74) Agent: HAUKAAS, Michael H.; 5100 Eden Avenue, Suite _ 303, Edina, Minnesota 55436 (US). (54) Title: SILK-DERIVED PROTEIN FOR TREATING INFLAMMATION = 1 . 5 — A e.v '••••••4 •••4 ee4v e••••0 .••• 4 1.0 = c*:•:1 ... 4 :::::::: NAN% ,:o ' ::o .:.:4 ox *4 0:4 4 , , H202 SIGNAL X: M 1......„ I I • • • (FOLD CONTROL) 0:+:; :* 1 .*x M 4:o 0 t i m, *:* 0.•40 = 4...0 SW4 I 1 = g C + • :: e••••0 • :•N • •• •4 C.:4•4 1,••11 + :4 W9 ......v ow : • A k x.:4 . A 4444 M _ 1-1 '• M IN CT - - 1 4.) M © -- -- GC (57) : Described herein are methods for reducing proteins (SDP) or a fraction thereof to a subject having 0 conditions and wounds, including corneal wounds, comprising N described herein. ;;;$ an 0.5% P A S F inflammation inflammatory condition. the topical a Fig. by administration 1 . 0 % SDP 5 administration The methods a of 5.0% SDP-4 of an effective amount of silk-derived include the treatment of inflammatory an effective amount of SDP material as C [Continued on next page] WO 2018/031973 Al MIDEDIMOHNOBEIERIMIDEMEIERVON Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of