baber/WOPTO huggingface dataset:
Patent CA-2942999-A1 (CA)
Title: Non-polar blue led epitaxial wafer based on lao substrate and preparation method thereof
Inventor: CAI ZHUORAN
IPC: H01L33/02
Filed: 2015-03-23
Abstract: A non-polar blue LED epitaxial wafer based on an LAO substrate and the preparation method therefor. The preparation method comprises the following steps: a) using the LAO substrate (10), selecting the crystal orientation, and cleaning the surface of the LAO substrate (S1); b) annealing the LAO substrate, and forming an AlN seed crystal layer on the surface of the LAO substrate (S2); and c) sequentially forming a non-polar m side GaN buffer layer (11), a non-polar non-doped u-GaN layer (12), a non-polar n-type doped GaN film (13), a non-polar InGaN/GaN quantum well (14), a non-polar m side AlGaN electron barrier layer (15) and a non-polar p-type doped GaN film (16) on the LAO substrate by using metallo-organic chemical vapor deposition (S3). With the non-polar blue LED epitaxial wafer based on the LAO substrate and the preparation method thereof, the non-polar blue LED epitaxial wafer has the advantages of low defect density, good crystal quality and good luminous performance; and the preparation cost is low.
Patent CA-2943355-A1 (CA)
Inventor: YANCOPOULOS GEORGE D
IPC: C07K16/22
Filed: 2015-03-25
Abstract: La présente invention concerne des agonistes de la signalisation de FGF21. En particulier, la présente invention concerne des agonistes du récepteur de FGF21 (FGF21R) qui peuvent lier simultanément ßKlotho (KLB) et/ou FGFR1c pour imiter l'activité de signalisation de FGF21. La présente invention concerne également des anticorps anti-FGF21 et anti-KLB/FGFR1c et leurs fragments de liaison aux antigènes. L'invention concerne également des procédés de traitement de divers troubles métaboliques par l'administration des agonistes de FGF21R et/ou des anticorps anti-FGF21 à un sujet qui en a besoin.
Patent CA-2945079-A1 (CA)
Inventor: WITKOWSKI BRIAN
IPC: E21B43/26
Filed: 2016-10-12
Abstract: A fitting is disclosed that includes a body; a first flow passage extending through the body; and a second flow passage formed in the body to intersect the first flow passage. The first and second flow passages define first and second longitudinal center axes, respectively. In an exemplary embodiment, the fitting forms a portion of a manifold assembly of a frac system. In one aspect, the fitting is formed by a manufacturing process such that the body has a parting plane that is offset from, and parallel to, the first longitudinal center axis. The fitting may have a first varying wall thickness defined between the first flow passage and the external surface; and a second varying wall thickness defined between the second flow passage and the external surface.  In another aspect, a curved surface is formed in the body at the intersection between the first and second flow passages.
Patent CA-2945788-A1 (CA)
Inventor: NIEDERWEIS MICHAEL
IPC: C07K14/35
Filed: 2015-04-16
Abstract: La présente invention concerne des Mycobacterium smegmatis porines (Msp) à chaîne unique mutantes et les utilisations de celles-ci.
Patent CA-2946398-A1 (CA)
Inventor: GARCIA K CHRISTOPHER
IPC: A61K38/00
Filed: 2015-04-24
Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2RP receptor and a decreased binding capacity for IL-2R?c receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL- 15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.
Patent CA-2948082-A1 (CA)
Title: Method for targeted conjugation of peptides and proteins by paired c2 bridging of cysteine amino acids
Inventor: GRIEBENOW NILS
IPC: C07K1/113
Filed: 2015-05-05
Abstract: The present application concerns a new method for targeted conjugation of peptides and proteins which is characterized by the C2 bridging of cysteine amino acids in pairs via their thiol groups, the conjugates of peptides and proteins that are obtainable by such a method, and the use of such conjugates in the diagnosis and/or treatment of disorders.
Patent CA-2948216-A1 (CA)
Title: Topographie de la peau utilisee en tant que marqueur pour la maturation de la peau
Inventor: LACHMAN NADEGE
IPC: A61B5/00
Filed: 2015-05-15
Abstract: La présente invention concerne un procédé de détermination du relief de la surface de la peau d'un sujet et, par conséquent, du degré de maturation de ladite surface de la peau. L'invention cocnerne également des procédés d'identification d'agents actifs, de matières premières et de formulation.
Patent CA-2949018-A1 (CA)
Inventor: PARANN-NISSANY GILAD
IPC: G06F21/62
Filed: 2015-05-14
Abstract: The present invention discloses methods and devices for securing keys when key- management processes are subverted by an adversary. Methods include the steps of: upon receiving a creation request in the computing-environment, creating a secure key in at least one location in a computing environment by repetitively computing respective secure-key contributions: in at least one location; and in a set of N computing resources in the computing environment, wherein N is a non-negative integer; and applying the respective secure-key contributions to change a secure-key value, wherein: the respective secure-key contributions cannot be omitted or modified by at least one location; and the secure key is never revealed to the computing resources; thereby enabling the computing resources in the computing environment to ensure that the secure key is truly random; wherein at least one location is a region of memory located in a computing resource operationally connected to the computing- environment.
Patent CA-2949463-A1 (CA)
Inventor: KIRBY GLEN HAROLD
IPC: C23C30/00
Filed: 2015-04-24
Abstract: A coated substrate (100) is provided that can include a substrate defining a surface (103), and an abradable coating (106) on the surface (103) of the substrate. The abradable coating (106) can comprise La2-xAxMo2-y-y'WyByO9-d forming a crystalline structure, where A comprises Li, Na, K, Rb, Cs, Sc, Y, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Th, Be, Mg, Ca, Sr, Ba, Cu, Bi, Cd, Zn, Ag, Au, Pt, Ir, Rh, Ru, Pd, or combinations thereof; 0 < x = about 0.2 (e.g., about 0.1 = x = about 0.15); 0 = y = about 1.5 (e.g., about 0.01 = y = about 1.5); B comprises Ta, Nb, V, Fe, Cr, Mn, Co, Ni, Sn, Ga, Al, Re, In, S, or combinations thereof; 0 = y' = about 0.2, wherein the sum of y and y' is about 0.01 to about 1.6; and 0 = d = about 0.2.
Patent CA-2949980-A1 (CA)
Title: Enrobages de parties reproductrices de plantes
Inventor: ANTON DOUGLAS ROBERT
IPC: A01N43/56
Filed: 2015-06-03
Abstract: La présente invention concerne un procédé d'enrobage d'une partie reproductrice de plante avec une couche de composition d'enrobage. Ladite composition d'enrobage, comprenant un liant filmogène, une charge, un pesticide et un véhicule aqueux, peut contribuer à augmenter l'absorption d'un pesticide par une plante résultante.
Patent CA-2950314-A1 (CA)
Inventor: NELSON HOWARD
IPC: A61L2/14
Filed: 2015-06-11
Abstract: Veterinary methods for administering nitric oxide (NO) in a plasma state to a treatment site associated with an animal are disclosed. A discrete stream of matter is placed in a plasma state, in which the stream has, as part of its content, a desired concentration of NO. The discrete stream of matter is directed at a site of action associated with an animal to achieve a therapeutic result. A method for decontamination of veterinary equipment with NO in a plasma state is also disclosed.
Patent CA-2951234-A1 (CA)
Inventor: WANG CHANGYU
IPC: G01N33/566
Filed: 2015-06-03
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
Patent CA-2952235-A1 (CA)
Inventor: NEWMAN DANIEL A
IPC: H05B3/02
Filed: 2015-06-15
Abstract: A basking heater (30) for an animal, such as a reptile, includes a housing (32), a heating element (34) within the housing, and an opening (40) in a bottom (36) of the housing, so that the heating element may radiate heat through the opening, and an attachment arrangement (110). The attachment arrangement can be used to selectively attach the heater to a terrarium (22). The housing can be made of thermal plastic resin and can include vents (64) for cooling the housing. The housing can have low profile shape. The heater may have multiple power settings.
Patent CA-2952670-A1 (CA)
Inventor: GUMINA RONALD J
IPC: H05B45/59
Filed: 2016-12-28
Abstract: Triac controlled dimmers and switches often employ a snubber circuit to prevent self-tripping and to reduce radio frequency emissions. Standard snubber circuits allow small amounts of AC current to reach the load even when the dimmer or switch is set to the off position, thereby causing unwanted illumination in certain high efficiency LED lighting. A load-side dynamic snubber circuit is provided for use in dimmers, switches, and similar applications which only activates the snubber circuit when the dimmer or switch is active, thereby preventing current from reaching the load when the dimmer or switch is in the off position.
Patent CA-2954879-A1 (CA)
Inventor: LIN NAN-HORNG
IPC: C07D239/72
Filed: 2015-06-15
Abstract: Composé pour le traitement d'une maladie ou ou d'un trouble associé à une protéine kinase, qui présente une structure de formule (I) dans laquelle L désigne NR8 ou O; et R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description. L'invention porte sur des composés de formule (I) qui sont utiles pour l'inhibition de protéines kinases. L'invention porte également sur des méthodes d'utilisation des composés de formule (I) et de leurs stéréo-isomères, leurs tautomères, et leurs sels de qualité pharmaceutique, pour diagnostiquer, prévenir ou traiter in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés.
Patent CA-2956242-A1 (CA)
Inventor: DARVILL WILLIAM JOHN
IPC: F24F7/007
Filed: 2015-07-23
Abstract: Humidifying apparatus includes a body and a nozzle detachably mounted on the body. The body includes a chamber, a water tank for supplying water to the chamber, and a motor-driven impeller for generating an air flow over water stored in the chamber. An ultraviolet radiation emitting lamp irradiates water stored in the chamber. The air flow is humidified with water from the chamber, and conveyed to the nozzle for emission from the apparatus. A sensor detects the position of the nozzle relative to the body, and a drive circuit controls the actuation of the lamp depending on an output from the sensor.
Patent CA-2956808-A1 (CA)
Inventor: PECK KONAN
IPC: C12N15/115
Filed: 2015-07-31
Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.
Patent CA-2957382-A1 (CA)
Inventor: WU XIAOLIN
IPC: C07H19/06
Filed: 2015-08-06
Abstract: Des modes de réalisation de cette invention concernent de nouveaux lieurs nucléotidiques modifiés qui augmentent l'efficacité de l'incorporation de nucléotides dans des applications de séquençage par synthèse. L'invention concerne également des procédés de préparation de ces lieurs nucléotidiques modifiés.
Patent CA-2957620-A1 (CA)
Inventor: COHEN DVIR
IPC: A61F2/30
Filed: 2015-09-04
Abstract: A device sized and shaped for insertion into a body comprising: at least one mechanical limb comprising: a support segment; a first flexible section extending from the support segment and terminating in a coupling section; and a second flexible section extending from the coupling section and terminating in a tool or a connector for a tool; wherein a long axis of one or more of the flexible sections is bendable in a single bending plane; wherein a long axis length of the first flexible section is at least double a maximum extent of the first flexible section perpendicular to a flexible section long axis; wherein a long axis length of the second flexible section is at least double a maximum extent of the second flexible section perpendicular to a flexible section long axis.
Patent CA-2961266-A1 (CA)
Inventor: KELLER ANDREAS
IPC: C12Q1/18
Filed: 2015-08-06
Abstract: The invention relates to a method of determining an infection of a patient with Klebsiella species potentially resistant to antimicrobial drug treatment by detecting mutations in the genes, parC, KPN 01607, gyrA, KPN 02451, baeR, aceF, ybgH, ynjE, KPN 01951, KPN 01961, KPN 02114, mhpA, KPN 02128, KPN 02144, KPN 02149, ydiJ, btuE, oppC, pth, KPN 02298, KPN 02302, dadA, yoaA, ftn, cbl, hisB, yegQ, yehY, KPN 02580, yejH, KPN 02621, yfaW, KPN 02170, KPN 02025, livG, livM, livH, fliY, yedQ, abgB, treA, baeS, KPN 02399, ydcR, anmK, ccmF, KPN 02440, KPN 02540, KPN 01752, and KPN 04195, and/or KOX 26125, KOX 13365, KOX 16735, KOX 25695, KOX 12270, and KOX 15055; a method of selecting a treatment of a patient suffering from an antibiotic resistant Klebsiella infection; and a method of determining an antibiotic resistance profile for bacterial microorganisms of Klebsiella species, as well as computer program products used in these methods. In an exemplary method, a sample is used for molecular testing and then a molecular fingerprint is taken. The result is then compared to a reference library and the result is reported.
Patent CA-2962605-A1 (CA)
Inventor: ADAMIAN VICTOR A
IPC: C07D307/68
Filed: 2015-10-07
Abstract: Methods for providing effective, efficient and convenient ways of producing 2,5- furandicarboxylic acid ate presented. In addition, compositions of 2,5-furandicarboxylic acid including 2,5 -furandicarboxylic acid and at least one byproduct are presented. In some aspects, 4-deoxy-5-dehydroglucaric acid is dehydrated to obtain the 2,5 -furandicarboxylic acid. A solvent, catalyst, and/or reactant may be combined with, the 4--deoxy-5-dehydroglucaric acid to produce a reaction product including the 2,5 -furandicarboxylic acid. In some arrangements, the reaction product may additionally include water and/or byproducts.
Patent CA-2962880-A1 (CA)
Inventor: DZUREC NICHOLAS ANDRE
IPC: F04D13/08
Filed: 2017-03-30
Abstract: A pump system for submersing into a slurry, the pump system including a pump body having an inlet for receiving the slurry; and a plate for mitigating coning, the plate being disposed adjacent the inlet and extending outwardly from the pump body. A method including submersing the pump system into a slurry; and pumping the slurry through the pump system.  An apparatus for mitigating coning around a submersible pump, the submersible pump comprising a pump body having an inlet, the apparatus including a plate for mitigating coning around the submersible pump in use, the plate being for disposing adjacent the inlet and extending outwardly from the pump body; and a plate positioning structure for holding the plate in position.
Patent CA-2965312-A1 (CA)
Inventor: HOLDER ERNEST JEFFERSON
IPC: G05D1/12
Filed: 2017-04-27
Abstract: A spatially-distributed architecture (SDA) of antennas transmits a set of uniquely coded signals. A first receiver having a known position in a coordinate system defined by the SDA receives reflected versions of the uniquely coded signals. A first processor receives the reflected versions of the uniquely coded signals and identifies a position of a non-cooperative object in the coordinate system. A platform having a second receiver receives non-reflected versions of the uniquely coded signals. The platform determines a position of the platform in the coordinate system. In an example, the platform uses a self-determined position and a position of the non-cooperative object communicated from the SDA to navigate or guide the platform relative to the non-cooperative object. In another example, the platform uses a self-determined position and information from an alternative signal source in a second coordinate system to guide the platform after a coordinate conversion.
Patent CA-2966137-A1 (CA)
Inventor: TAKAHASHI SHINICHI
IPC: H01M8/10
Filed: 2015-10-08
Abstract: The present invention relates to an electrode catalyst for a fuel cell, the electrode catalyst comprising a catalyst carrier the main component of which is carbon and a catalyst metal supported on the catalyst carrier, wherein according to Raman spectroscopy, a ratio R' (D'/G intensity ratio) of the D' band peak intensity (D' intensity) as measured at approximately 1620 cm-1 to the G band peak intensity (G intensity) as measured at approximately 1580 cm-1 is more than 0.6 but 0.8 or less, and the electrode catalyst satisfies at least one of (a) through (d). The present invention provides the electrode catalyst for a fuel cell, the electrode catalyst having superior gas transportability.
Patent CA-2967125-A1 (CA)
Inventor: BUFFA LAURA
IPC: C07D487/04
Filed: 2015-11-12
Abstract: The present invention relates to compounds of formula (I) (see formula I) wherein ring A and ring B are fused together to form a bicyclic system selected from naphthalene, 2,3-dihydroindole, and isoquinoline. Compounds of the invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET  family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
Patent CA-2967221-A1 (CA)
Title: Forward folding rotor blades
Inventor: FENNY CARLOS ALEXANDER
IPC: B64C39/06
Filed: 2017-05-11
Abstract: A rotor blade rotation system comprising a fold linkage (306) coupled to a rotating portion of a bearing plate (308a) and in mechanical communication with rotor blades (202), the fold linkage is positioned between the bearing plate and the rotor blade, an actuator is coupled to a non-rotating portion of the bearing plate (308b) to reposition the bearing plate from a first position to a second position such that the fold linkage pivots the rotor blades from a deployed position to a forward folded position. The rotation system is characterised in the tip of all the rotor blades are upstream from the hub (304) and the hub is upstream from the bearing plate when the rotor blades are in the forward folded position in contrast to backward folding rotor blades which may not be desirable for some aircraft designs.
Patent CA-2968389-A1 (CA)
Title: Compositions d'adjuvant et procedes associes
Inventor: MILLER TIMOTHY J
IPC: A61K45/00
Filed: 2015-11-27
Abstract: La présente invention concerne une composition d'adjuvant qui est adaptée pour un injectable ainsi qu'une administration transdermique. La composition d'adjuvant comprend généralement un lipophile, un polymère d'acide acrylique ou méthacrylique, une solution saline, du cholestérol, une saponine, et de l'hydroxyde de sodium. L'invention concerne en outre une composition de vaccin qui comprend généralement la composition du vaccin de la présente invention et un antigène. L'invention concerne en outre un procédé pour la vaccination d'animaux et d'humains utilisant la composition d'adjuvant de la présente invention.
Patent CA-2972072-A1 (CA)
Title: Novel glycan conjugates and methods of use thereof
Inventor: WU CHUNG-YI
IPC: G01N33/53
Filed: 2015-08-21
Abstract: The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.
Patent CA-2972890-A1 (CA)
Title: Viscosity measurement
Inventor: GAJJI BHARGAV
IPC: G01N11/14
Filed: 2015-03-26
Abstract: A system for measuring the viscosity of a fluid comprises a rotor cup; a bob disposed within the rotor cup and having a shaft rotatably coupled to the rotor cup; a bearing connecting the shaft of the bob to the rotor cup; a magnetic coupling comprising a first magnetic element connected to the shaft of the bob and a second magnetic element disposed outside the rotor cup adjacent to the first magnetic element; and an inertial measurement unit disposed adjacent to the second magnetic element which is capable of sensing rotation of the magnetic coupling.
Patent CA-2974542-A1 (CA)
Title: Microphone cover/reflector
Inventor: AVLIAV AVI
IPC: H04R1/08
Filed: 2017-07-24
Abstract: The present system provides a microphone cover assembly that is portable, lightweight, and can be used when the microphone is attached to a microphone stand or when it is unattached. The cover assembly provides environmental and physical protection for a microphone. In addition, the microphone cover can be used as a sound reflector when in an opened condition, eliminating the need for a separate microphone reflector when the microphone is in operation.
Patent CA-2978906-A1 (CA)
Inventor: GILMANSHIN RUDOLF
IPC: B01L3/00
Filed: 2016-02-16
Abstract: Described herein are microreactors and methods of modifying support particles using acoustic standing waves. A liquid medium containing suspended support particles is flowed along a flow path through a channel, and an acoustic standing wave is applied to the channel to hold the suspended particles at a point in the channel. The held particles are then subjected to one or more reactions by flowing biochemical reactants through the channel. Unbound biological reactant is optionally washed from the channel. The reacted support particles can be released from the acoustic standing wave for further processing using, for example, flow cytometry or fluorescence microscopy.
Patent CA-2983379-A1 (CA)
Title: Insert-type tool and thread mill
Inventor: OSAWA JIRO
IPC: B23G5/18
Filed: 2015-06-15
Abstract: An insert portion (3) of a thread mill (1A) is fixed to a leading end portion of a body (2A) using screws (8). The insert portion (3) is configured by overlaying an insert (4) for finish machining and an insert (5) for rough machining. On respective mating faces of the inserts (4, 5), convex portions and concave portions of the mating face of the insert (4) are overlaid with concave portions and convex portions of the mating face of the insert (5). The thread mill (1A) can cut a female screw in a hole formed in a workpiece by performing right-hand cut down-cut milling, for example. The inserts (4, 5) simultaneously cut an inner peripheral surface of the hole, and the rough machining and the finish machining can thus be performed in a single pass. By the convex portions and the concave portions of the respective mating faces of the inserts (4, 5) being overlaid with each other, the inserts (4, 5) partially overlap in their respective thickness directions.  As a result, a protrusion length of the insert portion (3) can be shortened.