baber/WOPTO huggingface dataset:
Patent NZ-311612-A (NZ)
Title: Polycyclic alkaloids for the treatment of pain and use thereof
Inventor: DIMAIO JOHN
IPC: A61K31/335
Filed: 1996-07-12
Abstract: PCT No. PCT/CA96/00467 Sec. 371 Date Mar. 25, 1998 Sec. 102(e) Date Mar. 25, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/03978 PCT Pub. Date Feb. 6, 1997Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention acts as agonists at the opiate receptor.
Patent NZ-335625-A (NZ)
Title: Pre-split concrete or masonry blocks
Inventor: SIEVERT DICK J
IPC: B28B17/00
Filed: 1997-11-03
Abstract: The specification describes pre-split concrete masonry units (CMU) with a splitter guide pattern in the top surface of the masonry unit.  The process described in Us 5,249,950 & US 5,062,610 is modified by forming a splitting pattern on the top, or "lips-up", surface of the pre-split concrete masonry unit.  A CMU is shown at reference numeral 10 in Fig. 1. As shown in Fig. 1, the splitting pattern comprises a transverse splitting groove 12, which intersects the two triangular-shaped recessed regions 14 and 16. The pattern is formed in the pre-split unit by the compressive action of the stripper shoe plate on the compacted mix held in the mold box. Appropriate raised surfaces are affixed to the face of the stripper shoe plate to accomplish this compressive, pattern forming action. Preferably, the depth of the splitting pattern on the pre-split unit is between 1/4 inch and 1 inch, and more preferably is between 1/4 inch and 1/2 inch. Other features of the CMU 10 are a pair of lips 18 and 20 integrally formed at the opposite ends of the top surface of the CMU, cores 22, 24, 26, and 28, and side grooves 3D, 32, 34, and 36.  In the preferred embodiment, splitting grooves 12, 30, 32, 34, and 36 are V-shaped grooves, with side walls each oriented at about forty-five degrees from the horizontal, so that they intersect at an angle of about ninety degrees. In the regions of the recessed areas 14 and 16, where the splitting groove diverges, the side walls of the groove continue the same angular orientation, to provide clearance for the splitter blade, which is preferably formed with a sixty degree working edge.
Patent NZ-503954-A (NZ)
Title: Shelf divider of resilent (and typically moulded) material with tongues to pass through slots in shelf and press against underside of shelf by ramping or resilience of tongues
Inventor: OGDEN ALAN
IPC: A47B96/04
Filed: 2000-04-12
Abstract: The shelf divider 1 has tongues 5 which are passed through shelf slots (not shown) and the divider is then moved along the direction of the tongues so that the tongue engages the underside of the shelf. The divider is of a moulded material with tongues being ramped as shown, or is of a material to enable the engagement to be achieved resiliently.
Patent NZ-507219-A (NZ)
Title: Gas meter and regulator combination having the meter placed in a high pressure region and upstream of the regulator
Inventor: GRAY JAMES ALASTAIR
IPC: G01F1/66
Filed: 1999-04-07
Abstract: A combination gas meter and regulator (10) is disclosed.  The meter (18) is disposed in a high pressure region upstream of the regulator (14).  The meter (18) includes an ultrasonic transmitter/receiver arrangement (20a, 20b) that transmits a relatively low frequency ultrasonic signal through a gas flow tube (22).  Variations in the time of flight of the signal are used to determine the gas flow.  The combination further includes a pressure sensor (24a, 24b) in the high pressure region, the output of the meter being a pressure compensated measurement of the gas flow.
Patent NZ-509235-A (NZ)
Title: Development of novel, highly chemoprotectant crucifer germplasm
Inventor: FAHEY JED W
IPC: A01H1/06
Filed: 1999-07-01
Abstract: A method for selecting a plant comprising: a) measuring the ratio of alkyl glucosinolate to indole glucosinolate in a tissue of a plant, and b) selecting the plant if the ratio is a specific number. The plant may be broccoli and cauliflower for example.
Patent NZ-510439-A (NZ)
Title: N-alkylaspartyldipeptide ester derivatives used as food sweeteners
Inventor: AMINO YUSUKE
IPC: A23L27/30
Filed: 1999-09-10
Abstract: N-alkylaspartyldipeptide ester derivative of formula (1), such as N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-µ-aspartyl]-L-phenylalanine 1-methyl ester, or its salt, can be used as a food sweetening agent where R1, R2, R3, R4 and R5 are independently a hydrogen atom, a hydroxyl group, an alkoxy group, an alkyl group or a hydroxy alkyloxy group or R1 and R2, or R2 and R3 combine together and denote a methylene dioxy group; R6, R7, R8, R9 and R10 are independently a hydrogen atom and an alkyl group and optionally two groups selected from R6, R7, R8, R9 and R10 may combine together and denote an alkylene group; R11 is a hydrogen atom, a benzyl group, a p-hydroxy benzyl group, a cyclohexyl methyl group, a phenyl group, a cyclohexyl group, a phenyl ethyl group or a cyclohexyl ethyl group; R12 is a hydrogen atom or an alkyl group, and R13 is an alkyl groups; provided that derivatives in which R6, R7, R8, R9 and R10 in their entirety denote a hydrogen atom at the same time, and those derivatives in which R6 denotes a methyl group, and R1, R2, R3, R4, R5, R7, R8, R9, R10 and R12 denote a hydrogen atom at the same time and R11 denotes a benzyl group or a p-hydroxy benzyl group, at the same time, and those derivatives in which R2 denotes a methoxy group, R3 denotes a hydroxyl group, R10 denotes a methyl group, R1, R4, R5, R6, R7, R8 and R9 denote a hydrogen atom at the same time, and R11 denotes a benzyl group or a p-hydroxy benzyl group, are excluded.
Patent NZ-511151-A (NZ)
Title: Producing milk calcium composition by adjusting pH of the whey to between 4-9 using lactic acid or lactate to produce a dispersible product
Inventor: KAWACHI YASUJI
IPC: A23L1/304
Filed: 2001-04-17
Abstract: A method for producing a milk calcium composition which is highly dispersible and tasty and is useful in preparing a calcium fortified drink or a food product is disclosed, wherein it comprises the steps of: obtaining a permeate containing lactic acid and lactic acid ion by treating whey with an ultrafiltration (UF) membrane or nanofiltration (NF) membrane; adjusting the pH of the permeate to separate and recover a slurry-like milk calcium precipitate; and admixing and homogenizing the separated slurry-like milk calcium precipitate with milk proteins to obtain a milk calcium composition.
Patent NZ-511338-A (NZ)
Title: Tool holder, typically for anode changing in aluminium smelting, with cable sheaves and high speed/low force and low speed/high force drives
Inventor: PIRON GERARD
IPC: B66D3/00
Filed: 2000-02-11
Abstract: In order to produce low force at high speed motor 15 drives worm 17, wheel 16 and drum 14 to lift sheaves 18 via cable 13. In order to produce high force at low speed motor 22 drives screw jack 20/21 to attachment to lift attachment 19. This is stated to be useful for lifting anodes which require a high break-out force over a small lift, and a much lower lift force over a much larger vertical distance.
Patent NZ-519379-A (NZ)
Title: Compositions isolated from M. vaccae and their use in the modulation of immune responses
Inventor: DELCAYRE ALAIN
IPC: A61P1/04
Filed: 2000-11-30
Abstract: Polypeptides and polynucleotides isolated from Mycobacterium vaccae and compositions comprising them.   The compositions also comprise a heterologous antigen (e.g. tumour-specific antigens, infectious disease antigens and autoantigens) and are used to enhance the Th1 or Th2 immune responses for treatment of mycobacterial infections, sarcoidosis, asthma, allergic rhinitis, chronic graft versus host disease, systemic lupus erythematosus, systemic sclerosis and cancer, tuberculosis, autoimmune thyroiditis insulin-dependent diabetes mellitus, multiple sclerosis, Crohn's disease, Helicobacter pyloris-induced peptic ulcers, transplanted organ rejection and unexplained recurrent naturally occurring abortions.
Patent NZ-519721-A (NZ)
Title: Rectangular shaped planar antenna comprising square and partial square elements defined with a bifurcated central connection
Inventor: VERNON PETER JOSEPH
IPC: H01Q5/10
Filed: 2002-06-21
Abstract: A Planar antenna (10) includes a rectangular conductive element formed from two squares elements (12,13), the square elements are defined within the rectangle by a centrally located and bifurcated return conductor which has two legs (41,42), each square element is connected at one end to a connector element (31) and at the other end to the return conductor (41,42). The dimensions of the square elements are chosen so as to maximize gain for selected radio frequencies. Furthermore, the antenna (10) includes one or more additional but partial square elements (17,18), each additional element terminating adjacent the respective square element (12,13) at one end and is defined by one leg of the return conductor (42,41) on one side.
Patent NZ-519977-A (NZ)
Title: Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
Inventor: GUNTHER ECKHARD
IPC: A61P35/00
Filed: 2000-12-19
Abstract: Substituted N-benzyl-indol-3-yl-glyoxylic acid derivatives of formula (I) and the use thereof in the treatment of tumoral diseases is disclosed. Application of pharmaceutical preparation containing at least one of the compounds of this formula or the salts thereof in the form of coated or uncoated tablets, capsules, solutions for infusion or ampoules, suppositories, patch, powdered preparations which can be inhaled, suspensions, creams and ointments is also disclosed.
Patent NZ-521370-A (NZ)
Title: Method of manufacturing glued laminated wood by pressing sheets sequentially against stepped staircase formation
Inventor: ABE YUKIO
IPC: B27D3/00
Filed: 2002-09-13
Abstract: Boards 11a,11b are sequentially hot pressed. As boards 11b (and subsequent boards) are hot pressed they are supported over their full top and bottom extent.
Patent NZ-521617-A (NZ)
Title: Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands
Inventor: FOULON LOIC
IPC: A61P5/10
Filed: 2001-04-02
Abstract: A compound of formula (I) is described, pharmaceutical compositions containing the compounds and their uses as ocytocin receptor ligands, wherein; R0 represents a group chosen from formula (i) or (ii), wherein; Z1 represents a chlorine, bromine, iodine or fluorine atom or a (C1-C4)alkyl, (C1-C4)alkoxy or trifluoromethyl group, Z2 represents a hydrogen, chlorine, bromine, iodine or fluorine arom or a (C1-C4)alkyl, (C3-C5)cycloalkyl, (C1-C4)alkoxy, (C3-C5)cycloalkoxy or (C1-C4)polyfluoroalkyl group, R5 represents T1W in which T1 represents û(CH2)m, it being possible for m to be equal to 0 or 1, and W represents a hydrogen, hydroxycarbonyl, carboxyl, (C1-C4)alkoxycarbonyl, 1,3-dioxolan-2-yl, or 1,3-dioxan-2-yl, -NR6R7, -NR8COR9, -CONR13R14, OR18, Z6 represents a chlorine, (C1-C4)alkyl or (C1-C4)alkoxy, R1 represents a (C1-C4)alkyl, (C1-C4)alkoxycarbonyl, phenyloxycarbonyl group or a T1-R22 group in which T1 is as defined above, and R22 represents hydroxyl or (C1-C4)alkoxy, R2 and R4 represent, independently of one another hydrogen chlorine or fluorine or a (C1-C4)alkyl or (C1-C4)alkoxy, R3 represents a chlorine, fluorine, (C1-C4)alkyl, (C1-C4)alkoxy, hydroxyl, (C1-C4)carbamoyl, (C1-C4)alkylcarbonylamino, nitro, cyano, trifluoromethyl, amino, (C3-C6)cycloalkylamino, (C1-C4)alkylamino, di(C1-C4)alkylamino, tri(C1-C4alkylammonium A-, pyrrolidine-1-yl, piperid-1-yl, piperazin-1-yl, morpholin-4-yl or hexahydroazepin-1-yl, and X and Y represent, independently of one another, a hydrogen, chlorine, bromine, iodine, fluorine, or (C1-C4)alkoxy or trifluoromethoxy.
Patent NZ-522318-A (NZ)
Title: Use of tryptophan from a seed source for treating diseases associated with reduced serotonin
Inventor: HUDSON SUSAN P
IPC: A23L1/305
Filed: 2001-05-24
Abstract: A  composition comprising at least partially  defatted meal   from   a   plant   source  containing   protein-bound tryptophan with a higher tryptophan content than said  plant source  and  a  carbohydrate source having a  high  glycemic index,  and  its  use in the preparation of  medicaments  to supplement   or  improve  tryptophan  metabolism   and   the treatment  of  disease  associated with  reduced  levels  of serotonin.
Patent NZ-527597-A (NZ)
Title: Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone
Inventor: STREHLKE PETER
IPC: A61K31/473
Filed: 2002-02-21
Abstract: Disclosed herein are quinoline, isoquinoline and phthalazine derivatives that are suitable as antagonists of the gonadotropin-releasing hormone.
Patent NZ-529086-A (NZ)
Title: Method for obtaining Muscodor fungi comprising screening the fungi with volatiles of Muscodor albus or Muscodor roseus under culturing conditions
Inventor: STROBEL GARY A
IPC: A01N63/30
Filed: 2002-04-11
Abstract: Described is an endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp and compositions comprising this Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.
Patent NZ-531450-A (NZ)
Title: Cancer marker comprising a negatively-charged molecule with a m/z ratio of about 991 that is present at a reduced level in a subject having a cancer compared with a healthy subject
Inventor: PARISH CHRISTOPHER RICHARD
IPC: C12Q1/68
Filed: 2002-08-05
Abstract: Provided are cancer markers for the diagnosis of cancer in humans and non-human mammalian subjects, specifically a cancer marker comprising a negatively-charged molecule with a mass/charge (m/z) ratio of about 991, wherein if the molecule is subjected to post-source ionization, it produces five fragments having an m/z ratio of about 241, about 644, about 705, about 749, and about 947. The cancer marker may be used to determine the presence of one or more cancerous cells or tumours in a biological sample by assaying the sample for a reduced level of said cancer marker.
Patent NZ-533175-A (NZ)
Title: Low-temperature hydrogen production from oxygenated hydrocarbons
Inventor: CORTRIGHT RANDY D
IPC: C01B3/22
Filed: 2002-11-27
Abstract: Disclosed herein is a method of producing hydrogen from oxygenated hydro-carbon reactants, such as methanol, glycerol, sugars (e.g. glucose and xylose), or sugar alcohols (e.g. sorbitol). The method takes place in the condensed liquid phase. A reactor (18) is disposed within a furnace (20). Liquid reactants are introduced into the reactor (18) via pump (16). Nitrogen supply (10) and hydrogen supply (12) are provided to maintain the overall pressure of the system and the partial pressure of hydrogen within the system chambers in and downstream of the reactor (18). Mass flow controllers (14) are provided to regulate the introduction of nitrogen and hydrogen into the system. A heat exchanger (22) is provided to reduce the temperature of the products exciting the reactor (18). The products are then swept into separator (24). Pressure regulator (28) and back-pressure regulator (26) serve to monitor and maintain the pressure of the system within the set value or range.
Patent NZ-533586-A (NZ)
Title: Method for the recovery and purification of poxviruses from infected cells using high pressure homogenisation
Inventor: HELLER KARL
IPC: A61K39/275
Filed: 2002-12-13
Abstract: Poxvirus can be recovered from infected cells by subjecting the infected cells to a high pressure homogenization to obtain a poxvirus containing homogenate, the homogenate may be further subjected to a purification step such as ultrafiltration or cross flow filtration. The poxvirus enriched fraction or poxvirus containing homogenate obtained can be used for the preparation of a vaccine. Preferably the poxvirus is selected from orthopoxviruses, avipoxviruses, suipoxviruses, capripoxviruses and vaccinia virus.
Patent NZ-540298-A (NZ)
Title: 5-Substituted-pyrazine or pyridine glucokinase activators
Inventor: CHEN SHAOQING
IPC: C07D213/76
Filed: 2003-12-11
Abstract: A compound according to formula (I) where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula (I) are also provided, said compounds being glucokinase activators which are useful in the treatment of type II diabetes.
Patent NZ-541928-A (NZ)
Title: Remedy for spinal injury containing interleukin-6 antagonist
Inventor: OKANO HIDEYUKI
IPC: A61P25/00
Filed: 2004-02-24
Abstract: Disclosed is the use of an antibody against interleukin-6 (IL-6) receptor for the manufacture of a therapeutic agent for spinal cord injury.
Patent NZ-544148-A (NZ)
Title: Multilayered peelable and resealable packaging film
Inventor: HAEDT EDWARD L
Filed: 2005-12-13
Abstract: Disclosed is a multilayer film for packaging applications comprising: (a) at least a polymeric first layer, a polymeric second layer, and a third layer; (b) wherein said polymeric first layer is an innermost exterior-film layer, said polymeric second layer is an internal-film layer and both polymeric first and second layers are coextruded together; (c) wherein said polymeric first layer has a first surface and an opposing second surface and comprises a heat-sealable, water-insoluble homopolymer or copolymer of polyester; (d) wherein said polymeric second layer has a first surface and an opposing second surface and comprises a pressure-sensitive adhesive; wherein said second surface of said polymeric second layer is in direct contact with and bonded to said first surface of said polymeric first layer such that a peelable/resealable bond is formed between said polymeric first and second layers; wherein said first surface of said polymeric second layer is in direct contact with and bonded to said third layer; and (e) wherein said third layer comprises a material selected from the group consisting of a thermoplastic material, a cellulosic material, a metallic material and combinations thereof.
Patent NZ-546031-A (NZ)
Title: Phenylacetic acid derivative, process for producing the same, and use
Inventor: KUSUDA SHINYA
IPC: A61P9/12
Filed: 2004-09-21
Abstract: Disclosed is a compound represented by formula (I) wherein X is a sulfur atom, an oxygen atom or a nitrogen atom which may have a substituent(s); RingA represents 4-(trifluoromethyl)piperindin-1-yl, 2,2-difluoro-1,3-benzodioxol-5-yl or 3,4-dihydro-1H-isoquinolin-2-yl, a salt thereof, or a solvate thereof or a prodrug thereof. Also disclosed is the use of the above compound for preparing a preventive and/or therapeutic agent for PPAR-mediated disease.
Patent NZ-546668-A (NZ)
Title: Hypo- and hyper-acetylated meningococcal capsular saccharides
Inventor: COSTANTINO PAOLO
IPC: C08B37/00
Filed: 2004-10-04
Abstract: Disclosed is a modified serogroup W135 meningococcal capsular saccharide conjugated to a carrier protein, wherein: (a) < 29% of the sialic acid residues in the saccharide are O-acetylated at the 7 position; and/or (b) > 26% of the sialic acid residues in the saccharide are O-acetylated at the 9 position. Also disclosed a modified meningococcal capsular saccharide, wherein the saccharide comprises n or more repeating units of the disaccharide unit: [sialic acid] - [hexose] where the hexose is either galactose or glucose and n is an integer from 1 to 100, and wherein: (a) < x% of the sialic acid residues in said n or more repeating units are O-acetylated at the 7 position; and/or (b) when hexose is galactose, > y% of the sialic acid residues in said n or more repeating units are O-acetylated at the 9 position, and when hexose is glucose, > y% or < z% of the sialic acid residues in said n or more repeating units are O-acetylated at the 9 position, where: when hexose is galactose, x is 29 and y is 26; and when hexose is glucose, x is 9, y is 29 and z is 27.
Patent NZ-546782-A (NZ)
Title: Improved synthesis of 2-substituted adenosines such as spongosine
Inventor: SAVORY EDWARD DANIEL
IPC: C07H1/00
Filed: 2004-12-03
Abstract: Disclosed is a method of synthesising a 2-substituted adenosine of formula I, wherein R is as defined in the specification, comprising converting 2-nitro-pentabenzoyl adenosine to the 2-substituted adenosine. Also disclosed is a method of synthesising 2-nitro-pentabenzoyl adenosine comprising converting pentabenzoyl adenosine to 2-nitro-pentabenzoyl adenosine. Also disclosed is a method of reducing the amount of TBAN or TMAN contaminating 2-nitropentabenzoyl adenosine formed by nitration of pentabenzoyl adenosine with TBAN or TMAN, which comprises washing the 2-nitro-pentabenzoyl adenosine with water.
Patent NZ-549553-A (NZ)
Title: Combination therapy involving 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (AZD2171) with 5-fluorouracil and / or irinotecan
Inventor: WEDGE STEPHEN ROBERT
IPC: A61K45/06
Filed: 2005-03-22
Abstract: Disclosed is the use of AZD2171 (4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline) or a pharmaceutically acceptable salt thereof excluding an AZD2171 maleate salt, and one of: a) 5-fluorouracil (5-FU); b) CPT-11 (irinotecan); and c) 5-FU and CPT-11 in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human. Also disclosed is the use of the above combination in the manufacture of a medicament for use in the production of an anti-cancer effect (including an anti-tumour effect) in a warm-blooded animal such as a human. In addition, a pharmaceutical composition which comprises the above combination is also disclosed, as is a kit comprising AZD2171 or a pharmaceutically acceptable salt thereof, and one of: a) 5-fluorouracil (5-FU); b) CPT-11 (irinotecan); or c) 5-FU and CPT-11.
Patent NZ-549713-A (NZ)
Title: Crystalline form A of a known thiophenecarboxylic acid dodecahydrocyclopenta (a) phenanthrenyl ester
Inventor: JORDINE GUIDO
IPC: C07J33/00
Filed: 2003-07-28
Abstract: Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S,9R,10S,11S,13S,16R,17R)-9-chloro-6-fluoro-11-hydroxy-l7-methoxycarbonyl-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-l7-yl ester of formula (I) are disclosed. The crystal forms possess anti-inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described. Particularly disclosed is a compound of formula (I) in a crystal form A that has a melting point, by Differential Scanning Calorimetry, of about 264 deg. C with simultaneous decomposition, at a heating rate of 20 deg. C/min and the diffraction lines (2theta in angular degrees ñ 0.2 deg.) in the X-ray diffraction pattern as defined in the specification. (62) Divided Out of 537868