Patent SG-11201808524Q-A (SG)
Title: Devices, systems and methods for inhibiting invasion and metastases of cancer
Inventor: HAMILTON GERALDINE
IPC: C12M1/02
Filed: 2017-03-30
Abstract: Filing Language: (26) Publication Language: (30) Priority Data: 62/315,401 30 March 2017 (30.03.2017) English English 30 March 2016 (30.03.2016) US ( 84 ) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/173066 Al 5 October 2017 (05.10.2017) WIPO I PCT 1111111111111101110101011111010111110 0101111101111101111111111111111111110111111 (51) International Patent Classification: C12M 1/02 (2006.01) Cl 2N 5/06 (2006.01) C12N 5/16 (2006.01) (21) International Application Number: PCT/US2017/024988 (22) International Filing Date: (71) Applicant: EMULATE, INC. [US/US]; 27 Drydock, Bo- ston, MA 02110 (US). (72) Inventors: HAMILTON, Geraldine, A.; 509 East 2nd Street, Unit #7, Boston, MA 02127 (US). WEN, Norman; 4975 Washington Street, Unit #18, West Roxbury, MA 02132 (US). KARALIS, Catherine; 9 Colbourn Crescent #2, Brookline, MA 02445 (US). VARONE, Antonio; 4975 Washington Street, Unit 118, West Roxbury, MA 02132 Published: (US). LEVNER, Daniel; 55 Sewall Avenue, 5C, Brook- line, MA 02446 (US). BARRILE, Riccardo; 24 Queens- berry Street, Boston, MA 02215 (US). = (74) Agent: CARROLL, Peter G.; Medlen & Carroll, LLP, 1440 Broadway, Suite 1010, Oakland, California 94612 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) W O 20 1717 / 3066 Al (54) Title: DEVICES, SYSTEMS AND METHODS FOR INHIBITING INVASION AND METASTASES OF CANCER Figure 1 Source: Douglas Harahan, Robert A. Weinberg, Cancer Cal all (57) : The invention generally relates to a microfluidic platforms or \"chips\" for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with im- mune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.