Patent SG-11201808003R-A (SG)
Title: Bromodomain inhibitors
Inventor: FIDANZE STEVEN D
IPC: A61P13/12
Filed: 2017-04-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 HO 111110111010111011111111011011111011110111111 International Bureau ... .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,,, WO 2017/177955 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: 60061 (US). MCDANIEL, Keith F.; 26029 W. Laurel CO7D 471/04 (2006.01) A61P 35/00 (2006.01) Court, Wauconda, Illinois 60084 (US). PRATT, John; CO7D 487/04 (2006.01) A61P 31/18 (2006.01) 8210 61st Avenue, Kenosha, Wisconsin 53142 (US). A61K 31/407 (2006.01) A61P 13/12 (2006.01) SCHRIMPF, Michael; 327 Cambridge Dr., Grayslake, A61K 31/437 (2006.01) A61P 3/10 (2006.01) Illinois 60030 (US). SHEPPARD, George S.; 807 Locust (21) International Application Number: Road, Wilmette, Illinois 60091 (US). WANG, Le; 338 PCT/CN2017/080511 East Colonial Drive, Vernon Hills, Illinois 60061 (US). LI, Bing; c/o AbbVie Inc., 1 N. Waukegan Road, North Chica- (22) International Filing Date: go, Illinois 60064 (US). 14 April 2017 (14.04.2017) (74) Agent: CHINA PATENT AGENT (H.K.) LTD.; 22/F., (25) Filing Language: English Great Eagle Center, 23 Harbour Road, Wanchai, Hong Kong (CN). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, PCT/CN2016/079362 15 April 2016 (15.04.2016) CN AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Road, North Chicago, Illinois 60064 (US). DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (71) Applicant (for LC only): ABBVIE PHARMACEUTIC- KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, AL TRADING (SHANGHAI) CO., LTD. [CN/CN]; Part MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, _ 418, No.458 North Fu Te Road, Waigaoqiao Bond Area, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, — _ Shanghai 200131 (CN). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (72) Inventors: FIDANZE, Steven D.; 320 Rock Hall Circle, Grayslake, Illinois 60030 (US). HASVOLD, Lisa A.; 552 TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ = Shakespeare Drive, Grayslake, Illinois 60030 (US). LIU, (84) Designated States (unless otherwise indicated, for every Dachun; 1276 Georgetown Way, Vernon Hills, Illinois kind of regional protection available): ARIPO (BW, GH, [Continued on next page] = (54) Title: BROMODOMAIN INHIBITORS H 3 C..,... N NH R 1 (57) : The present invention provides for compounds of formula (I) wherein R I , R, R, R, R 2 3 4 6 , X 1 , and X' have any of the values defined in the specification, and pharmaceutically acceptable salts there- of, that are useful as agents in the treatment of diseases and conditions, including inflam- matory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I). — = = = - = = = R4 (I) 2 = OH ,-, ir) ir) R6 R3 R2 01 IN IN 11 IN 11 0 N O WO 2017/177955 Al IMEDIMOMOIDEIRMEMOMMEHHHEIMOVOIMIE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Published: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, DE, LT, — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, SE, GA, claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).