baber/WOPTO huggingface dataset:
Patent CA-2950778-A1 (CA)
Inventor: PASTERNAK ALEXANDER
IPC: C07D401/00
Filed: 2015-07-09
Abstract: The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Patent CA-2955077-A1 (CA)
Inventor: BRADNER JAMES E
IPC: A01N43/58
Filed: 2015-08-07
Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, neurological diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
Patent CA-2955328-A1 (CA)
Title: Systeme et fonctionnalite d'endoscope souple
Inventor: TERLIUC GAD
IPC: A61B1/008
Filed: 2007-05-17
Abstract: Linvention décrit un ensemble dendoscope auxiliaire à souplesse améliorée à utiliser avec un endoscope. Lensemble comprend un élément allongé souple ayant une section transversale extérieure avec un diamètre. Un manchon allongé souple possède une première lumière pour loger une partie distale dun endoscope capable dassumer au moins une première courbure et une seconde lumière pour loger lélément allongé souple. La seconde pour loger est conçue pour définir, au moins le long dune partie de létendue allongée de celle-ci, un déplacement transversal dun élément allongé logeant un volume avec une étendue transversale au moins deux fois la longueur du diamètre de la section transversale de lélément allongé souple.
Patent CA-2958912-A1 (CA)
Inventor: DIETZ GERNOT
IPC: G03F7/14
Filed: 2015-08-27
Abstract: Disclosed is an apparatus for producing flexographic printing plates from flexographic printing elements that can be provided with digital images. Said apparatus makes it possible to carry out in an automated manner at least the method steps of exposing the rear side, a main exposing process, developing the plates using washout substances, drying and after-treating the plates. The disclosed apparatus comprises at least two different conveying devices which convey the flexographic printing elements and plates through the apparatus. Also disclosed is a method for producing flexographic printing plates using the aforementioned apparatus.
Patent CA-2960097-A1 (CA)
Title: Boisson lactee stable dans des conditions ambiantes, conditionnee
Inventor: KAPCHIE VIRGINIE
IPC: A23C9/154
Filed: 2015-10-30
Abstract: L'invention concerne un produit conditionné, essentiellement constitué d'une boisson lactée aseptique placée dans un contenant fermé. La boisson peut être rendue mousseuse par agitation pour produire une agréable texture mousseuse.
Patent CA-2962080-A1 (CA)
Title: Co-cristal constitue de 4:3 naltrexone: 5-methyl-2-furaldehyde
Inventor: BARBIER REMI
IPC: A01N43/42
Filed: 2015-09-24
Abstract: Co-cristal constitué de 4:3 naltrexone : 5-méthyl-2-furaldéhyde et son utilisation comme antagoniste opioïde. L'invention concerne également un timbre adhésif transdermique de type médicament dans adhésif contenant du fentanyle analgésique, un agoniste opioïde mu, ou un analogue de celui-ci et un co-cristal constitué de 4:3 naltrexone : 5-méthyl-2-furaldéhyde,en tant qu' antagoniste opioïde. Le timbre transdermique de l'invention est inviolable et constitue un moyen anti-abus qui protège contre le mésusage des médicaments ou contre la toxicomanie. L'invention concerne également un procédé de traitement de la douleur, telle qu'une douleur aiguë, chronique, ou intermittente, par application d'un médicament dans un timbre adhésif transdermique selon l'invention sur la peau d'un patient le nécessitant. L'invention concerne également un timbre transdermique amélioré pour l'administration de fentanyle ou d'un analogue de celui-ci, ou pour l'administration d'un agoniste opioïde mu, l'amélioration dans laquelle le timbre transdermique contient un co-cristal constitué de 4:3 naltrexone : 5-méthyl -2-furaldéhyde dans une quantité limitant l'abus. Le timbre transdermique amélioré peut être un médicament dans un timbre adhésif transdermique ou un timbre transdermique à réservoir.
Patent CA-2966538-A1 (CA)
Inventor: CRISMAN RYAN L
IPC: C12M3/00
Filed: 2015-11-04
Abstract: L'invention concerne des procédés, des systèmes et des kits pour le traitement de cellules, par exemple, pour une utilisation thérapeutique, comme une thérapie cellulaire adoptive. Les procédés de l'invention comprennent des procédés de transduction, dans lesquels des cellules et des virus sont incubés dans des conditions qui provoquent la transduction des cellules avec un vecteur viral. L'incubation dans certains modes de réalisation est effectuée dans une cavité interne d'une chambre de centrifugation généralement rigide, telle qu'une chambre cylindrique faite de plastique dur, dont la cavité peut avoir un volume variable. Les procédés comprennent d'autres étapes de traitement, notamment celles mises en uvre dans une telle chambre, notamment le lavage, la sélection, l'isolement, la culture et la formulation. En particulier, l'invention concerne un procédé qui présente des avantages par rapport aux procédés de traitement disponibles, comme les procédés disponibles pour un traitement à grande échelle. Ces avantages comprennent, par exemple, un coût réduit, une rationalisation, une efficacité accrue, une sécurité accrue et une reproductibilité entre les différents sujets et les différentes conditions.
Patent CA-2970927-A1 (CA)
Title: Agents cytotoxiques cibles vers tlr9
Inventor: LIST ALAN F
IPC: A61P35/00
Filed: 2015-10-30
Abstract: La présente invention concerne des compositions et des procédés pour le traitement ciblé de cancers exprimant TLR9. En particulier, l'invention concerne des molécules contenant un ligand ciblant TLR9, tel qu'un oligodésoxynucléotide CpG, qui ciblent des agents cytotoxiques vers des cellules malignes exprimant TLR9. L'invention concerne des compositions et des procédés pour le traitement ciblé de cellules cancéreuses ou de cellules souches cancéreuses présentant une expression de TLR9 extracellulaire, telles que des progéniteurs de MDS humains primaires et des cellules souches hématopoïétiques (HSC). En particulier, des molécules contenant des ligands ciblant TLR9 qui ciblent des agents cytotoxiques vers des cellules malignes exprimant TLR9.
Patent CA-2972958-A1 (CA)
Title: Microfluidic cell culture of patient-derived tumor cell spheroids
Inventor: BARBIE DAVID
IPC: C12N5/09
Filed: 2016-01-07
Abstract: Provided herein are methods for culturing patient-derived tumor cell spheroids in a three-dimensional microfluidic device. The method comprises mincing primary tumor sample in a medium supplemented with serum; treating the minced primary tumor sample with a composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 µ?? to 500 µ?? from the enzyme treated sample; suspending the tumor spheroids in biocompatible gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods for identifying an agent for treating cancer and microfluidic devices that allow for the simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a treatment of choice and to control treatment are also provided.
Patent CA-2973014-A1 (CA)
Inventor: MIYATA POMAIKAI
IPC: A43B5/00
Filed: 2017-07-12
Abstract: This is a portable, temporary and completely reversible method of adapting a shoe generally used for sports training (with rubberized sole) into a modified shoe (with low coefficient of friction) capable of specialized activity needed for figure skating training (to find and keep axis orientation, primarily, but not limited to: jumps, spins and pivots) on a variety of floor surfaces. This method comprises: providing a piece of material to completely cover the front half sole of the shoe (from toe to the point the arch begins) with the properties for creating greatly reduced friction with the floor surface. The half sole piece is held in place by a configuration of elastic material which connects to the device's sole at front and side edges, and slips over the upper portion of the shoe. An additional band of elastic material extends around the back of the shoe to secure the sole piece from back to front much like a sandal overshoe.
Patent CA-2974008-A1 (CA)
Inventor: TAYLOR JESSE WADE
IPC: F16L21/08
Filed: 2017-07-19
Abstract: A conduit fitting for a hazardous environment includes a main body that has a distal portion and a proximate portion. The main body includes a longitudinal bore with openings at each of the distal portion and the proximate portion. The opening is configured to receive ends of a conduit. The fitting includes a first sealing region that includes a crimp feature configured to be crimped and a second sealing region adjacent the first sealing region. The second sealing region is configured to house a sealing component. The first and second sealing regions are configured to create an explosion proof seal around an end of the conduit.
Patent CA-2974470-A1 (CA)
Title: Photoluminescent writing pad and notepad or notebook
Inventor: KINNUNEN KALLE
IPC: B42D13/00
Filed: 2016-02-02
Abstract: A photoluminescent writing pad (1), wherein a) the writing pad (1) is fastened to a back cover of a notebook and arranged to be turned to a writing pad of a page of the notebook, b) the writing pad (1) is arranged to gleam through a writing page thus enabling reading and writing in darkness and c) the writing pad (1) comprises notches (4) for accommodating a spiral wire, especially spiral or wire or similar binding, of a notebook for securing the writing pad (1) under the page of the notebook to function as an interleaf.
Patent CA-2974491-A1 (CA)
Inventor: VAN ROOSMALEN JEROM FERDINANDUS
IPC: F25J3/02
Filed: 2016-02-03
Abstract: The invention provides a system for liquefying an incoming gaseous fluid comprising at least 50% by volume methane, said system provided for providing an outgoing liquefied fluid comprising a methane content of at least 58% by volume. The invention further provides a method for liquefying a gaseous fluid, said method comprising: - providing an incoming gaseous fluid comprising at least 50% by volume methane; - increasing a pressure of said incoming gaseous fluid to between 10 and 50 bar; - pre-treating said gaseous fluid with increased pressure, said pre-treatment comprising filtering said gaseous fluid using membrane filtering to a retentate with a pressure of between 10 and 50 bar, a temperature of between 0°C and 50°C, a carbon dioxide content below 2 % by volume, a water content below 10 ppm and a methane content of at least 85% by volume; - liquefying said pre-treated fluid, said liquefying comprising cryogenic cooling said fluid to a temperature between -100°C and -140°C a pressure of between 10 and 50 bar and a methane content of at least 85% by volume; - flashing said liquefied fluid into a container, retrieving liquid fluid from said container at a first container level at a pressure of between 1 and 10 bar, a temperature of between -120°C and -160°C and a methane concentration of at least 85% by volume into a storage device and retrieving a slurry flow comprising solid C02 and water ice at a second container level below said first container level.
Patent CA-2974877-A1 (CA)
Inventor: ROL CORREDOR JAVIER
IPC: E02F3/80
Filed: 2016-02-22
Abstract: The present invention relates to a fixing device for fixing a wear or protection element (5) on a bucket of an earth moving machine, comprising: - a base (7) with a housing (15) with a front wall (17) and a rear wall (19) with a through hole (21), - a stop (9), with a lower part (25) housed in the housing (15), - a screw (11) going through the hole (21) and having an end thereof fixed to the stop (9), - partially compressed elastic means (13) arranged between the screw (11) and the hole (21). When the elastic means (13) are fully compressed, they have a length L0.  In a mounted position, the stop (9) has a front face (27) opposite the front wall (17), where the distance between both is D1 and the distance between said head and said hole (21) has a value D2, and the condition D2 - L0 > D1 is met in the mounted position.
Patent CA-2976421-A1 (CA)
Inventor: VIGANO LAURA
IPC: C09K8/08
Filed: 2016-02-15
Abstract: L'invention concerne un procédé pour inhiber le gonflement et la dispersion de schistes dans le traitement de formations de schiste souterraines comprenant l'utilisation d'une gomme de tamarin cationique et de fluides pour le traitement de formations de schiste souterraines comprenant une gomme de tamarin cationique.
Patent CA-2977066-A1 (CA)
Title: Transmission of system information on a downlink shared channel
Inventor: DAHLMAN ERIK
IPC: H04W80/02
Filed: 2008-04-10
Abstract: In one embodiment, a method of transmitting system information on a downlink shared channel structured as successive subframes includes transmitting (400 - 416) system information in regularly occurring time windows, each time window spanning some number of successive subframes. The method further includes indicating (406 / 408) to receiving user equipment (120) which subframes within a given time window carry system information. The method and variations of it are applied, for example, to the transmission of dynamic system information on the downlink shared channel or other downlink channel in a 3GPP E-UTRA wireless communication network (100).
Patent CA-2977666-A1 (CA)
Inventor: CROSBY KEVIN
IPC: A01N25/30
Filed: 2016-02-29
Abstract: Compositions and methods for controlling pathogens including nematodes fungi oomycetes and bacteria afflicting a broad variety of crop species by application to soil of a non-phytotoxic formulation of a blend of fatty acids disclosed. The fatty acid compostions are prepared as emulsifiable concentrates and applied directly to the soil or solid growing medium where the plant in need of treatment is growing.
Patent CA-2980370-A1 (CA)
Inventor: AUS DER FUNTEN SANDRA
IPC: B65D85/804
Filed: 2016-03-07
Abstract: The invention relates to a portion pack (1) for preparing beverages, in particular tea or coffee, comprising a container (2), in which a substance suitable for beverage preparation is arranged, wherein the container (2) is liquid-permeable at least in some regions or can be perforated during the beverage preparation, and an adapter (3), which can be inserted into a machine for beverage preparation, wherein the container (2) is releasably fastened to the adapter (3). Thus, the adapter (3) can be reused to prepare a plurality of beverages. Because the adapter (3) absorbs the mechanical loads in the device and provides the interfaces to the device, the container (2) can be produced in a cost-optimized manner. Furthermore, additional functionalities such as coding or biodegradability can be realized in a simple manner.
Patent CA-2980656-A1 (CA)
Inventor: LABREUCHE CHRISTOPHE CAMILLE
IPC: G06Q90/00
Filed: 2016-03-23
Abstract: L'invention concerne un procédé permettant de déterminer des actions tactiques pour protéger une entité de référence (RE) par rapport à une pluralité d'entités dans un environnement de champ de bataille, le procédé consistant à : - segmenter l'environnement de champ de bataille en une pluralité de couches (L1, L2, L3, L4, L5), - associer des systèmes de dissuasion actionnables à chaque couche (L1, L2, L3, L4, L5) ; - obtenir des données représentant la probabilité, pour chaque système de dissuasion, que le système de dissuasion considéré dissuade une entité dans la couche associée (L1, L2, L3, L4, L5) ; - fournir, pour chaque entité, le niveau de menace de ladite entité ; et calculer une fonction de coût pour déterminer les systèmes de dissuasion qui doivent être engagés par l'entité de référence (RE) pour rendre la fonction de coût extrême, la fonction de coût étant une fonction dépendant du niveau de menace fourni et des données obtenues.
Patent CA-2981252-A1 (CA)
Inventor: MALGAT ALEXANDRE
IPC: A24D1/22
Filed: 2016-03-30
Abstract: The present invention relates to a smoking article (100) including a combustible heat source(102), an aerosol-forming substrate (104) downstream of the combustible heat source, and a wrapper (120) circumscribing the aerosol-forming substrate and at least a rear portion (136) of the combustible heat source. The smoking article further includes gripping means (134) on the wrapper for gripping the combustible heat source. The gripping means comprises a plurality of inwardly extending sharp teeth (210) fixed to an inner surface of the wrapper and arranged to grip the combustible heat source.
Patent CA-2984613-A1 (CA)
Inventor: SNYDER SCOTT
IPC: F04B39/14
Filed: 2016-05-05
Abstract: A noise mitigation boot that can be installed on or integrated into a miniature diaphragm pump to reduce the overall noise and improve sound quality during operation. The diaphragm pump includes a housing having first and second ports and an interior chamber, a pumping diaphragm disposed in the interior chamber and dividing the interior chamber into a pumping chamber and a backside chamber, a motor for reciprocating the pumping diaphragm for pumping air into and out of the pumping chamber, and flow passages connecting the pumping chamber to the first and second ports. The first port is configured for attachment to a flow line and the second port opens to an exterior surface of the housing. The noise mitigation boot has a muffler wall overlying the exterior surface of the housing. The muffler wall has formed therein a passage extending from the second port to the backside chamber for effecting fluid communication between the second port and the backside chamber.
Patent CA-2986355-A1 (CA)
Inventor: SANTARELLI FREDERIC JOSEPH
IPC: E21B43/267
Filed: 2016-06-02
Abstract: A method of increasing hydrocarbon production by hydraulic fracturing in shale formations by using an a-seismic process of cyclic injection of cooled aqueous fluid at a low rate with shut-in periods to induce tensile failure in the formation and create a fracture network of high and very high conductivity fractures with sufficient lateral extension in a completed well. A final single cycle of aqueous fluid and proppant is used in which the volume of proppant has been determined from measurements of the downhole pressure. Further fracture parameters being : volume of the very high conductivity fractures, lateral extension of the very high conductivity fractures, surface of the very high conductivity fractures and estimation of the global fracture network shape are determined and analysed after each injection cycle.
Patent CA-2987052-A1 (CA)
Title: Systeme et procede de gestion d'espace de stationnement
Inventor: BLUSTEIN TOMER
IPC: G07F17/00
Filed: 2016-05-03
Abstract: La présente invention concerne un système de gestion d'un espace de stationnement. Le système comprend : a) un serveur pour gérer et contrôler l'accès de véhicules à l'espace de stationnement ; b) au moins un capteur de détection de véhicule adapté pour détecter la présence d'un véhicule à un point de passage spécifique de l'espace de stationnement, la détection d'un véhicule déclenchant la transmission de signaux sans fil par au moins une balise associée à une porte de passage au niveau dudit point de passage ; c) un module de contrôle d'accès adapté pour ouvrir/fermer ladite porte de passage et, en conséquence, indiquer l'état de ladite porte de passage ; et d) un dispositif de communication de terminal d'utilisateur adapté pour recevoir et identifier lesdits signaux sans fil et, en conséquence, informer ledit serveur et/ou ledit module de contrôle d'accès après identification de ladite au moins une balise, ce qui permet ainsi au dit serveur et/ou au dit module de contrôle d'accès d'exécuter des tâches relatives au stationnement.
Patent CA-2988086-A1 (CA)
Inventor: VOLKMAN BRIAN F
IPC: A61P19/02
Filed: 2016-05-31
Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis, inflammatory disorders and autoimmune disease.
Patent CA-2988202-A1 (CA)
Inventor: RODRIGUEZ TORRADO RUBEN
IPC: G06Q10/06
Filed: 2016-06-03
Abstract: The present invention is related to a method of generating a production strategy for the development of a reservoir of hydrocarbon in a natural environment by solving a minimization problem involving, among others, decisional variables, in such a way said decisional variables are reduced or even eliminated by combining them with other continuous variables. The reduction of decisional variables provides a high reduction of the computational cost. The elimination of all decisional variables allow a further reduction of the computational cost as solvers such as Mixed Integer Nonlinear Programming allowing the use of decisional variables that are not needed anymore. A particular case of decisional variables are binary variables.
Patent CA-2989246-A1 (CA)
Inventor: ESPE ROLF
IPC: D21H19/02
Filed: 2016-06-17
Abstract: The invention relates to the fitting of decorative and/or overlay papers impregnated with aminoplast resin, which are used for the coating of composite wood panels and form an abrasion-resistant, easy-clean and hydrophobic surface, characterized in that, after resin impregnation, the impregnated papers are coated in a second application step with a sol-gel preparation containing dissolved metal alkoxides and fullerene-like nanostructures and nanotubes made of metal disulfides of the metals molybdenum and/or tungsten, and in that, after drying and final condensation, the surfaces are formed in a hydraulic heating press.
Patent CA-2991918-A1 (CA)
Inventor: MAHONY JAMES
IPC: C12Q1/68
Filed: 2015-07-10
Abstract: A point-of-care device for detecting a target nucleic acid is provided. The device comprises: an extraction chamber adapted to receive a biological sample, wherein said extraction chamber comprises means to extract and lyse the sample to release nucleic acid; a first amplification chamber in communication with the extraction chamber, wherein said amplification chamber comprises means to trigger nucleic acid amplification of a target nucleic acid sequence to occur; and a detection chamber in communication with the amplification chamber, wherein said detection chamber comprises means to detectably label the target nucleic acid and means to detect a signal associated with labeled target nucleic acid.
Patent CA-2992858-A1 (CA)
Title: Method and system for measuring an x-ray image of an area undergoing medical examination
Inventor: TRAUTWEIN FRANK THILO
IPC: A61B34/00
Filed: 2018-01-25
Abstract: A method for measuring an X-ray image of an area undergoing medical examination that has at least one object. A 3D model is provided of the area undergoing examination that includes a virtual 3D object to be assigned to the object to be measured, a digitally reconstructed X-ray picture is computed based on the 3D model and under the assumption of a virtual projection direction, the X-ray image is compared with the digitally reconstructed X-ray picture, the virtual projection direction is changed relative to the virtual 3D object. The steps of comparing and changing are repeated until a virtual projection direction with maximum correlation between the X-ray image and the digitally reconstructed X-ray picture is found. An object plane is determined that is to be assigned to the virtual 3D object. A corrected projection direction is defined and the X-ray image is measured.