baber/WOPTO huggingface dataset:
Patent NZ-500427-A (NZ)
Title: The use of ribozyme treatment for retinal diseases
Inventor: LEWIN ALFRED S
IPC: A61K35/76
Filed: 1998-04-21
Abstract: A composition comprising a ribozyme that cleaves mRNA encoding a protein associated with a retinal disease, wherein the protein is selected from P23H mutant rod opsin, S334 mutant rod opsin, VEGF, eNOS, and iNOS. Also described is the use of this composition in the manufacture of a medicament for use in the treatment of a retinal disease.
Patent NZ-504718-A (NZ)
Title: Automatic liquid injection system and method whereby the syringe is subjected to continuous rotation or rocking motion
Inventor: SCHNEIDER MICHEL
IPC: A61K9/22
Filed: 1998-12-04
Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent.  The injector has a syringe (22) whose barrel (25) contains the suspension, and automatic electromechanical power source (24, 31, 34) controllably acting on the syringe to inject the suspension into a patient.  The injector further has a drive motor unit with an agitator (30a, 30b) for continuously rocking and rotating the syringe so as to keep the microparticles in the suspension.  The rocking and rotating agitation keeping the suspension homogenous by preventing segregation of the microparticles by gravity or buoyancy without damaging the microparticles or disturbing their distribution.
Patent NZ-504769-A (NZ)
Title: N-[(substituted five-membered di- or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia
Inventor: HAMANAKA ERNEST S
IPC: A61K31/41
Filed: 1999-02-05
Abstract: Disclosed are substituted guanidine compounds of formula I, wherein: Z is a heterocyclic radical or formula (i), (ii), (iii) or (iv), for which the further substituents are defined herein. The compounds are used in the manufacture of medicaments for reducing tissue damage resulting from ischemia in a mammal
Patent NZ-504884-A (NZ)
Title: Synthesis of the dihydroindole C-ring of CC-1065/duocarmycin analogs and certain intermediates
Inventor: BOGER DALE L
IPC: C07B61/00
Filed: 1998-12-08
Abstract: The dihydroindole C-ring found in CC-1065/duocarmycin analogs is formed by the 5-(exo-trig) radical cyclization of an aryl halide onto a tethered vinyl chloride forming with chlorine installed as a suitable leaving group for subsequent cyclopropane spirocyclization. Also disclosed are various compounds of formula as depicted.
Patent NZ-507761-A (NZ)
Title: Use of ROR receptors for screening substances useful for the treatment of atherosclerosis
Inventor: RASPE ERIC
IPC: G01N33/566
Filed: 1999-03-24
Abstract: Use of the ROR receptors and/or of their response element or alternatively of a functional equivalent thereof for the screening of substances having antiatherosclerotic. A method of screening substances useful in the treatment of lipid metabolism dysfunctions, characterized in that the test substance is brought into contact with a receptor of the ROR family or a response element of the ROR receptor and/or a nuclear factor capable of functionally coupling ROR to the RNA polymerase complex, or a functional equivalent thereof, and then measuring by any appropriate means: - the binding of the said substance to the ROR receptor and/or its functional equivalent or the binding of the complex formed of the said substance and the ROR receptor to its response element and/or to a nuclear factor capable of functionally coupling ROR to the RNA polymerase complex, and/or - the modulation of the transcriptional activity of a gene placed under the control of a promoter comprising the said response element.
Patent NZ-509229-A (NZ)
Title: Treating raw wool with gaseous sulphur trioxide to sulphonate fats surrounding each woollen fibre
Inventor: OMORI HIDEKI
IPC: D06M101/12
Filed: 2001-01-08
Abstract: A method for degreasing and carbonizing raw wool with gaseous sulfur trioxide comprises contacting the raw wool with sulfur trioxide gas to sulphonate fat surrounding wool fibres of the raw wool and to carbonate burrs and other vegetable matter and scouring the raw with alkali water solution to neutralize the sulphuric acid resulting from the contacting of the raw wool with sulfur trioxide gas and to emulsify the fat remaining unsulphonated. The fat sulphonated and unsulphonated are removed from the raw wool.
Patent NZ-515053-A (NZ)
Title: Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit
Inventor: GOTWALS PHILIP
IPC: A61P17/02
Filed: 2000-04-21
Abstract: An antibody or antibody homolog that antagonizes an interaction between an alpha4 subunit-bearing integrin and a ligand for the alpha4 subunit-bearing integrin can be used in the preparation of a medicament for the treatment of a subject suffering from pulmonary fibrosis or for decreasing fibrotic condition-induced increases in leukocytes in bronchoalveolar lavage fluid of a subject. The antibody or antibody homolog is a humanized antibody having a portion thereof encoded by a nucleic acid sequence comprising a nucleic acid that hybridizes under high stringency conditions to a nucleic acid sequence encoding a polypeptide sequence selected from the group consisting of: VKLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPASG DTKYDPKFQVKATITADTSSNTAWLQLSSLTSEDTAVYYCADGMWVSTGYA LDFWGQGTTVTVSS; SIVMTQTPKFLLVSAGDRVTITCKASQSVTNDVAWYQQKPGQSPKLLI YYASNRYTGVPDAFTGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSPYTFGGGTKLEI; and A variable domain of the antibody produced by cell line ATCC CRL 111754
Patent NZ-515106-A (NZ)
Title: Telecommunications network resource handling arrangement and method
Inventor: NORDSTROM KLAS
IPC: H04L12/70
Filed: 2000-05-04
Abstract: A resource handler for use in an operational support structure for managing a telecommunications network comprises a service and resource database containing information regarding network resources. The database arrangement is structured so that each resource in the network has a time of existence as well as a place in a hierarchy of parent/child(s) relations. The resource is defined by the following data: a point (11) identifier that has characteristics associated to it, in the form of an abstract description of its capabilities; an abstraction of the common network element (10) in the sense of a group of points (11) that are considered to belong together; and a connection (12) which is defined by two connected points.
Patent NZ-517740-A (NZ)
Title: Apoptin-associating protein and its use in the detection the presence of cancer cells
Inventor: NOTEBORN MATHIEU HUBERTUS MARI
IPC: C12Q1/02
Filed: 2000-09-01
Abstract: An  isolated or recombinant nucleic acid  encoding  an apoptin-associating  proteinaceous  substance   capable   of providing  apoptosis, or functional equivalent or functional fragment thereof is disclosed. Apoptosis is an active and programmed physiological  process for  eliminating  superfluous, altered or  malignant  cells, which  is  characterised by shrinkage of cells, segmentation of  the  nucleus,  condensation and  cleavage  of  DNA  into domain-sized   fragments,  in   most   cells   followed   by internucleosomal degradation.
Patent NZ-522457-A (NZ)
Title: Liposomes containing hydrophobic iodo compound
Inventor: AIKAWA KAZUHIRO
IPC: A61K9/127
Filed: 2001-04-26
Abstract: A liposome containing a hydrophobic iodine compound such as a 1, 3, 5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a vascular disease and the like.
Patent NZ-523147-A (NZ)
Title: Tubular elastic fleece retention device used in biological de-fleecing
Inventor: LEBRETON JOHN LESLIE
IPC: A01K14/00
Filed: 2002-12-13
Abstract: A fleece retention device (10) for use in biological de-fleecing of fleece-bearing animals (L). The device (10) includes a substantially tubular section (11), composed of elastic material, expandable for receiving the body of a fleece-bearing animal (L) during fitting of the device (10).  A method and frame (20) for fitting the device (10) are also disclosed.
Patent NZ-524738-A (NZ)
Title: Method for heteroatom lattice substitution in large and extra-large pore borosilicate zeolites
Inventor: CHEN CONG-YAN
IPC: B01J29/04
Filed: 2001-09-12
Abstract: A method for preparing a large pore or extra large pore zeolite having lattice substituted heteroatoms comprising: a) Contacting calcined borosilicate zeolite with an acid, thereby producing an at least partially deboronated zeolite; and b) Contacting the at least partially deboronated zeolite with a salt-containing aqueous solution comprising one or more salts selected from the group consisting of aluminum salt, gallium salt, and iron salt, thereby producing a silicate zeolite having a lattice comprising aluminum atoms, gallium atoms, iron atoms or a combination thereof; wherein step b) is conducted at a pH of about 3.5 or less, the salt-containing aqueous solution comprises aluminum salt, gallium salt, iron salt or mixture thereof in a weight ratio of the partially deboronated zeolite to the salt from about 1:1 to about 1:100, and the salt containing aqueous solution has a water content of about 50 weight percent to about 99.5 weight percent.
Patent NZ-525143-A (NZ)
Title: Beta-thio-amino acids
Inventor: CHIZH BORIS
IPC: A61P25/28
Filed: 2001-09-11
Abstract: Disclosed herein are beta-thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, medicaments containing these compounds and the use of these thioamino acids for producing medicaments. These medicaments are suitable for the treatment of pain, epilepsy, migraine, hyperalgesia, allodynia, hot flushes, post-menopausal symptoms, amyotropic lateral sclerosis (ALS), reflex sympathetic dystrophy (RSD), spastic paralysis, restless leg syndrome, acquired nystagmus; psychiatric or neuropathological disorders such as bipolar disorders, anxiety, panic attacks, mood fluctuations, manic behavior, depression, manic-depressive behavior; painful diabetic neuropathy, symptoms and pain due to multiple sclerosis or Parkinson's disease, a neurodegenerative disease; gastrointestinal lesions; erythromelalgic or post-poliomyelitic pain, trigeminal or post-herpes neuralgia; or as an anticonvulsant, analgesic or anxiolytic.
Patent NZ-526079-A (NZ)
Title: Crystalline glucosamine sulphate metal salts and processes for preparing the same
Inventor: MUKHOPADHYAY TRIPTIKUMAR
IPC: C07H5/04
Filed: 2001-12-03
Abstract: Crystalline glucosamine sulphate metal salts for use in the treatment of acute and chronic forms of rheumatic and arthritic diseases and pathological conditions originating from metabolic disorders of the osteo-articular tissues are disclosed. Particularly described are crystalline glucosamine sulphate metal salts having low metal content wherein the metal may be either sodium or potassium. A solution-based and a solvent-free process for the preparation of crystalline glucosamine sulphate metal salts having low metal content and to pharmaceutical compositions comprising the crystalline glucosamine sulphate metal salts having low metal content are also disclosed.
Patent NZ-528400-A (NZ)
Title: New process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
Inventor: VAYSSE-LUDOT LUCILE
IPC: C07D333/38
Filed: 2003-09-23
Abstract: A process for the industrial synthesis of the compound of formula (I), characterised in that dimethyl 3-oxoglutarate of formula (V) is reacted with malononitrile of formula (VI) in methanol, in the presence of morpholine in an amount greater than 0.95 mol per mol of compound of formula (V), to yield the compound of formula (VII), which is then reacted with sulphur in an amount greater than 0.95 mol per mol of compound of formula (V), the mix is then heated at reflux and the compound of formula (I) is isolated by precipitation in the presence of water, followed by filtration.
Patent NZ-533103-A (NZ)
Title: Depot medicament, carrier materials for depot medicaments, and method for the production thereof
Inventor: KOHLER BERTHOLD
IPC: A61K47/48
Filed: 2003-01-24
Abstract: A depot medicament having a pharmacological active ingredient and a carrier, wherein the carrier is produced with use of a carrier material which comprises a carrier polymer formed from a polypeptide and a biodegradable polyester covalently linked thereto.
Patent NZ-546023-A (NZ)
Title: Metal/metal oxide fueled engine
Inventor: WALTON DARREN KENNETH
Filed: 2006-03-21
Abstract: A method of producing a sustained and contained thermite reaction to produce energy for providing drive power to a vehicle, turbine or generator is disclosed. The method includes the steps of: (i) introducing a thermite mixture containing a higher metal and an oxide of a lower metal into a chamber; (ii) igniting the thermite mixture to form a thermite reaction within the chamber; (iii) controlling the rate of feed of at least one of the essential components of the thermite mixture; (iv) introducing steam or water into the chamber such that the steam or water contacts the molten form of the resultant metal produced from the lower metal oxide constituent of the thermite reaction; (v) volatilising or raising in pressure of the water or steam by the heat of the thermite reaction to raise the pressure within the chamber; and (vi) using the raised pressure to drive a piston or shaft or turbine.
Patent NZ-547087-A (NZ)
Title: Child-resistant closure container and package
Inventor: EILERTSON STEPHEN A
IPC: B65D41/04
Filed: 2004-12-02
Abstract: A child-resistant package (20) includes a container (24) having a finish (28) with an open end (36), at least one external thread (34), at least one stop lug (32) projecting radially outwardly from the finish, and a closure (22) having a base wall (56), a skirt (60) with at least one internal thread (64) for engagement with the thread on the container finish, at least one spring element (58), and at least one pair of internal lugs (76, 78) on the skirt and extending radially inwardly from the skirt. Each pair of lugs on the skirt includes a first lug (76) that cooperates with the stop lug on the container finish to prevent unthreading of the closure from the finish absent pressure on the closure against the spring element to push the first lug on the skirt beneath the corresponding stop lug on the container finish, and a second lug (78) circumferentially spaced from the first lug that cooperates with the stop lug on the container finish to prevent "over-threading" or over tightening of the closure on the finish.
Patent NZ-556285-A (NZ)
Title: Method for simulating ammunition fire from a weapon
Inventor: LINDERO BJORN
IPC: F41G3/26
Filed: 2006-02-24
Abstract: Disclosed is a method of simulating fire and simulating ammunition (13) from a weapon. The method comprises the steps of: determining a trajectory of simulated ammunition; emitting a light beam along a simulation axis (23, 24); determining a point in time when the simulated ammunition passes a target (10); determining a value (d1, d2) related to the distance between the axis and a momentary position of the simulated ammunition along the trajectory at the point in time; and emitting the light beam coded with the value during a predetermined time period.
Patent NZ-561027-A (NZ)
Title: 7-(2-(4-(3-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoline besylate salt, preparation and therapeutic use thereof
Inventor: BARRE CORINNE
IPC: A61K31/472
Filed: 2006-03-15
Abstract: Disclosed is the 7-(2-(4-(3-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoline besylate salt, as shown in formula (II). Also disclosed is a process for the preparation of the salt. Also disclosed is the use of the salt to treat immune or inflammatory disorders, such as rheumatoid arthritis.
Patent NZ-566663-A (NZ)
Title: Fused heterocyclic compounds useful as kinase modulators
Inventor: VACCARO WAYNE
IPC: A61K31/437
Filed: 2006-09-22
Abstract: Disclosed is a imidazo[1,2-b]pyridazine according to formula (I), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt, thereof, wherein: E is C; F is N. X, Z, Y, R1 and R2 are defined in the specification. Also disclosed are compositions comprising said pyridazine and the use of said pyridazine in the treatment of a variety of conditions including pancreatitis, hepatitis and AIDS.
Patent NZ-567835-A (NZ)
Title: Sulfur-containing proanthocyanidin oligomer composition
Inventor: NONAKA GEN-ICHIRO
IPC: A23L1/30
Filed: 2004-05-25
Abstract: Disclosed is a proanthocyanidin compound represented by Formula (6). Also disclosed is the use of the above compound for the manufacture of a medicament for the treatment and/or prevention of hyperlipemia (hyperlipidemia), hypercholesterolemia, hypertension, diabetes, cancers, organ related dysfunctions and/or brain related dysfunctions or for the prevention of diseases caused by the generation of active oxygen species.
Patent NZ-569186-A (NZ)
Title: Enzymes for reduced immunological stress
Inventor: ANDERSON DAVID M
IPC: A61K38/43
Filed: 2006-12-14
Abstract: Disclosed is an animal feed composition suitable for oral administration to an animal comprising an immune stress-reducing enzyme in an effective amount to decrease the level of positive acute phase protein in said animal, increase the level of negative acute phase protein in said animal, and/or improve animal growth performance in an orally acceptable carrier, wherein: i. said effective amount is at least 20 IU enzyme/kg feed; ii. said enzyme is other than a beta-mannanase-type hemicellulase or phospholipase; and iii. said enzyme is selected from the group consisting of 1,3-beta-glucanase, beta-glucosidase, xyloglucanase, RNAse L, dsRNA specific adenosine deaminase, CG specific restriction endonucleases, N-glycanases, alpha-1,2-fucosidase, alpha-1,3-1,4-fucosidase, alpha-1,6-mannosidase, alpha-1,2-mannosidase, alpha-1,3-mannosidase, beta-1,4-galactosidase, endo-beta-N-acetylglucosaminidase F (endo F), peptide-N-(N-acetyl-beta-glucosaminyl)asparagine amidase F (PNGase F), PNGase A, endo-beta-N-acetylglucosaminidase H (endoH), endo D, endo C, alpha-N-acetylgalactosaminidase, beta-1,3-galactosidase, endo-N-acyl-neuraminidase (endo N), a-2,3-neuraminidase, a-2,6-neurminidase, alpha-2,8-neuraminidase, beta-N-acetylhexosaminidase, endo-beta-N-galactosidase, endo-alpha-N-acetylglactosaminidase, endo-alpha-1,6-D-mannanase, arabinogalactanase, alpha-mannanase, alpha-mannosidase, sphingomyelinase, chitinase, chitin deacetylase, carbohydrate deacetylase, N-acetylglucosaminidase, phosphatidylserine decarboxylase, sulfatase, beta-galactosidase, arabinanase, hyaluronidase, alpha-arabinofuranosidase, chondroitinase, glucocerebrosidase, methyl esterase, ferulic acid esterase, furuloyl esterase, acetyl esterase, phosphorylcholine hydrolase, alkaline phosphatase, acid phosphatase, phosphorylcholine esterase and phosphorylcholine phosphatase.
Patent NZ-570368-A (NZ)
Title: Apparatus and methods for treating allograft products
Inventor: RONHOLDT CHAD
IPC: A61F2/46
Filed: 2006-11-08
Abstract: An apparatus and method for treating allografts. The apparatus includes a sonication tank configured to transmit ultrasonic energy to the interior of the tank. The sonication tank contain a sonication fluid. The apparatus includes a treatment canister supported by the sonication tank, the treatment canister is configured to receive and rotatably position allografts within. The treatment canister is sealed with respect to the sonication tank such that the sonication fluid cannot enter the interior of the treatment canister. The apparatus further includes a treatment fluid source having a line in fluid communication with, and rotatably coupled to, the treatment canister. The treatment fluid source is configured to supply a treatment fluid to the interior of the treatment canister supported by the sonication tank. The line is configured to allow simultaneous rotation of the canister and exchange of the treatment fluid within the treatment canister. The apparatus further includes a fluid control system adapted to allow exchanging of the treatment fluid in the treatment canister without removing the allografts from the treatment canister.
Patent NZ-570380-A (NZ)
Title: Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant
Inventor: LIN HAIXIANG
IPC: A61K33/06
Filed: 2006-06-27
Abstract: Disclosed is an immunogenic composition comprising: (a) a polynucleotide adjuvant comprising: a polyriboinosinic-polyribocytidylic acid (PIC), at least one antibiotic, and at least one positive ion; and (b) at least one antigen; wherein the composition is formulated for mucosal administration.
Patent NZ-571863-A (NZ)
Title: Homogenous magnetic filed generator with a gap between magnet sub-arrays at the centre of an assembly
Inventor: PARKINSON BENJAMIN JOHN
IPC: G01R33/20
Filed: 2007-04-18
Abstract: Disclosed is an apparatus for generating a homogeneous magnetic field. The apparatus comprises of an assembly (250) having a plurality of sub-arrays (251a-251j), each sub-array comprising of a plurality of permanent magnets disposed in an annular array about an axis. The sub-arrays are provided in a single layer, and a separation (253e) is provided between two of the sub-arrays (251e, 251f) that are disposed at or toward the centre of the assembly along the longitudinal axis. This provides a homogeneous magnetic field in an area within the assembly as indicated by the second order derivatives of the principal component of the magnetic field being substantially zero in three orthogonal directions.
Patent NZ-578485-A (NZ)
Title: Scaffolding plank with tongue and groove edges and end jointer
Inventor: CLEVELAND LEWIS ROY
IPC: E04G5/08
Filed: 2007-12-20
Abstract: A scaffolding plank 4 includes a main body and connectors (inter-latching tongue and groove arrangement) on both of the opposite long side walls of the body which cooperate with complementary connectors of like laterally adjacent planks to connect the planks side by side to each other. The plank is also provided with a projection 7, 10 that extends from an end wall of the main body and has a shape and form complimentary to an aperture formed in an end wall of a like plank so that the planks can be secured to each other end to end. The end jointing component 7 for joining the planks end to end is independently claimed. (62) Divided Out of 552072
Patent NZ-579044-A (NZ)
Title: Method and system for assembling pallets for stock orders
Inventor: BERRY PAUL ARMSTRONG
IPC: B65G65/00
Filed: 2008-02-15
Abstract: 579044 Disclosed is a method of determining a sequence for an assembly of pallets (14, 20) containing stock units for the fulfilment of a batch of stock orders. The orders contain order lines that represent the quantities of individual stock units required in specified pallets to fulfil the batch of orders. The method comprises identifying, using at least one processor executing a computer program, one or more matches of the order lines for a first stock unit where the combined quantity of the first stock unit in each match is equal to a predetermined value or is within a predetermined range; and determining, using at least one processor executing a computer program, a sequence for the assembly of pallets utilising those matches, wherein the sequence is determined to increase the opportunities to use negative pick/put transfers in the assembly of pallets. Also disclosed is a distribution system comprising: a work area for receiving at any one time, one or more donor pallets each containing a quantity of a stock unit and one or more recipient pallets arranged to receive stock units, and a control system operative to control the transfer of stock units from the donor pallets to the recipient pallets in the work area so as to establish desired quantities of the stock units in the donor and recipient pallets for use in the fulfilment of stock orders. The control system is operative to sequence the assembly of pallets in the distribution area in accordance with the above described method