Patent SG-11201810525X-A (SG)
Title: Anti-gitr antibodies and uses thereof
Inventor: DELFINO FRANK
IPC: C07K16/28
Filed: 2017-06-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/214548 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/395 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/US2017/036818 claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) — 09 June 2017 (09.06.2017) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/348,353 10 June 2016 (10.06.2016) US 62/432,023 09 December 2016 (09.12.2016) US 62/500,312 02 May 2017 (02.05.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (72) Inventors: DELFINO, Frank; c/o Regeneron Pharmaceu- _ ticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). SKOKOS, Dimitris; c/o Regeneron — Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tar- = rytown, New York 10591 (US). WANG, Bei; c/o Regen- _ eron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). =_ = Agent: CROWLEY-WEBER, Cara, L. et al.; Brownstein = (74) Hyatt Farber Schreck, LLP, 410 Seventeenth Street, Suite 2200, Denver, CO 80202 (US). = = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = _ = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every (84) = — kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = — 1-1 GC 71' EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). In 71' 1-1 ei N (54) Title: ANTI-GITR ANTIBODIES AND USES THEREOF 1-1 0 (57) : Provided herein are antibodies, and antigen-binding fragments thereof that specifically bind glucocorticoid-induced ei tumor necrosis factor receptor (GITR) and methods of using the same, including, e.g., methods of treatment using the same.