baber/WOPTO huggingface dataset:
Patent CA-3118354-A1 (CA)
Inventor: SASMAL SANJITA
IPC: A61K31/50
Filed: 2019-04-26
Abstract: The present invention provides pyridazine derivatives of formula (I), which are therapeutically useful as SMARCA2/4 degraders. These compounds are useful in the treatment and/or prevention of diseases or disorders dependent upon SMARCA2/4 in a mammal. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the pyridazine derivatives of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer thereof.
Patent CA-3118690-A1 (CA)
Inventor: BAILEY MICHAEL P
IPC: A61P35/00
Filed: 2019-11-05
Abstract: Disclosed is a method of treating cancer, e.g., refractory cancer, with tivozanib. The methods disclosed include, for example, administering tivozanib as a second or third-line therapy to subjects suffering from refractory advanced renal cell carcinoma where traditional therapies as well as more recent targeted and immune-oncology therapies have not adequately treated the subject.
Patent CA-3119557-A1 (CA)
Title: A flywheel arrangement
Inventor: MURPHY GARY
IPC: F03G3/08
Filed: 2019-11-11
Abstract: A flywheel arrangement comprising a shaft with a flywheel fixedly connected thereto. The flywheel comprises at least one cavity and that cavity is at least partially filled with particulate matter.
Patent CA-3121170-A1 (CA)
Title: Next-generation molecular profiling
Inventor: ABRAHAM JIM
IPC: G06N5/02
Filed: 2019-12-02
Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that strongly correlate with response of colorectal cancer patients to FOLFOX. Described herein are data structures, data processing, and machine learning models to predict effectiveness of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising administration of 5-fluorouracil/leucovorin combined with oxaliplatin (FOLFOX) or with irinotecan (FOLFIRI).
Patent CA-3122324-A1 (CA)
Title: Remote connectivity using a battery
Inventor: McCracken Lisa
IPC: H04W52/02
Filed: 2019-12-30
Abstract: The present disclosure describes a method for communicating sensor data to a remote server, the method according to one disclosed non-limiting embodiment of the present disclosure can include transferring network credentials to a sensing device, inserting a new battery into the sensing device, transferring the network credentials from the sensing device to the new battery, transferring a subset of data from one or more sensors of the sensing device to the new battery, establishing communications with a remote server using the network credentials, and sending the subset of data to the remote server.
Patent CA-3123568-A1 (CA)
Title: System for attachment of ac unit vents to casement or awning windows
Inventor: LOCK BARBARA LYNN
IPC: E06B7/28
Filed: 2021-06-30
Abstract: The embodiments of the invention relate to a transparent panel or window insert of corresponding shape and size to a casement or awning window. The transparent panel or window insert is attached to the frame of a casement or awning window or an insect screen by way of a series of releasable fasteners around the outer perimeter of the transparent panel or window insert. A void, corresponding to the shape and size of a A/C hose is cut into the transparent panel or window insert. In some embodiments of the invention the void may be bayoneted to cooperate with bayonette-style hose connections.
Patent CA-3123885-A1 (CA)
Inventor: KHAN RIAZ JAN KJELL
IPC: A61B5/00
Filed: 2019-12-19
Abstract: A method for intraoperative state analysis and classification of articular tissue comprising the steps of: sensing data of the articular tissue via a plurality of sensors situated in proximity to the articular tissue for detecting a response to a stimulus; determining state analysis and classification information through a verified means; processing the sensed data into a form adapted to be evaluated against a comparator; generating a means of predicting the state analysis and classification utilizing a historical dataset of processed information; and performing the state analysis and classification using the generated means based on processing the stimulus response obtained intraoperatively.
Patent CA-3124152-A1 (CA)
Title: Bearing housing assembly
Inventor: MORENKO OLEG
IPC: F01D25/16
Filed: 2021-07-07
Abstract: A bearing housing cover for a gas turbine engine having an impeller. The bearing housing comprises an annular collar having a flange mountable to an exterior surface of a bearing housing. The bearing housing further comprises an impeller baffle integrated with the annular collar, the impeller baffle having an annular body with a front baffle face positionable adjacent a rear face of the impeller, a rear baffle face having a plurality of stiffening elements extending between the rear baffle face and the annular collar, and a central baffle opening.
Patent CA-3124663-A1 (CA)
Inventor: KARAKI KEISUKE
IPC: B01D3/34
Filed: 2019-12-17
Abstract: L'invention concerne un procédé d'élimination de différence de pression pour éliminer, pendant le fonctionnement, la perte de pression (différence de pression) qui se produit en raison de sels attribués à et provoqués par des impuretés dans une matière première dans un équipement de distillation, sans affecter négativement la qualité et l'efficacité de production d'un produit. Ce procédé est destiné à éliminer l'apparition d'une différence de pression attribuée au dépôt de sels dans un équipement de distillation, le procédé utilisant un composé d'ammonium quaternaire représenté par la formule générale (1) en tant qu'agent d'élimination de sel. (Dans la formule (1), R1, R2, et R3 représentent chacun d'une manière indépendante un groupe hydrocarbure ayant 1 à 4 atomes de carbone, et n représente un entier de 1 à 10.)
Patent CA-3126110-A1 (CA)
Inventor: WAGENAAR TIMOTHY R
IPC: C07K16/28
Filed: 2020-01-17
Abstract: This disclosure relates to the field of therapeutic RNAs for treatment of subjects that have failed, or become intolerant, resistant, or refractory to an anti-programmed cell death 1 (PD-1) or anti-programmed cell death 1 ligand 1 (PD-L1) therapy, including innate and acquired PD-1 and/or PD-L1 therapy, as well as in subjects with advanced-stage, unresectable, or metastatic solid tumor cancers with or without failure, intolerance, resistance, or refraction to an anti-programmed cell death 1 (PD-1) or anti-programmed cell death 1 ligand 1 (PD-L1) therapy.
Patent CA-3126250-A1 (CA)
Title: Recovering and simulating pedestrians in the wild
Inventor: YANG ZE
IPC: G06N20/00
Filed: 2021-07-28
Abstract: Systems and methods for generating simulation data based on real-world dynamic objects are provided. A method includes obtaining two- and three-dimensional data descriptive of a dynamic object in the real world. The two- and three- dimensional information can be provided as an input to a machine-learned model to receive object model parameters descriptive of a pose and shape modification with respect to a three-dimensional template object model. The parameters can represent a three-dimensional dynamic object model indicative of an object pose and an object shape for the dynamic object. The method can be repeated on sequential two- and three-dimensional information to generate a sequence of object model parameters over time.  Portions of a sequence of parameters can be stored as simulation data descriptive of a simulated trajectory of a unique dynamic object. The parameters can be evaluated by an objective function to refine the parameters and train the machine-learned model.
Patent CA-3131212-A1 (CA)
Inventor: CHENG JAMES
IPC: F21S45/435
Filed: 2021-09-17
Abstract: The invention discloses an inner circulation heat-dissipating LED lamp cap, comprising a shell, a control circuit, and a power supply circuit, wherein one side of the shell is connected with a light-emitting component; the outside of the shell is installed with a metal holder; the inside of the shell is provided with a heat-dissipating component; the output end of the heat-dissipating component directly faces the light-emitting component; the high pressure airflow generated by the heat-dissipating component is blown to the light-emitting component to take away the heat, and then an inner circulation warming airflow is formed inside. The spiral jet fan forms a high- pressure airflow in the lamp body, which quickly blows away the surface and internal temperature of the lamp bead, with better heat conduction performance and more stable use of the whole machine.
Patent CA-3131670-A1 (CA)
Inventor: KAMIKAWABATA MASAHITO
IPC: H01F27/24
Filed: 2019-12-17
Abstract: This laminated core includes a plurality of electromagnetic steel sheets laminated in a thickness direction. The electromagnetic steel sheets each have: an annular core back portion; and a plurality of teeth portions projecting radially from the core back portion and arranged at intervals in the circumferential direction of the core back portion. Teeth portions of an electromagnetic steel sheet located on one outer side along the laminating direction, among the plurality of electromagnetic steel sheets, are bonded to each other by adhesive portions provided between the teeth portions adjacent to each other in the laminating direction; teeth portions of an electromagnetic steel sheet located on the other outer side along the laminating direction are bonded to each other by adhesive portions provided between the teeth portions adjacent to each other in the laminating direction; and teeth portions of an electromagnetic steel sheet located at the center along the laminating direction are not bonded to each other.
Patent CA-3138182-A1 (CA)
Title: Cycloalkyles substitues utilises en tant que modulateurs de la voie integree au stress
Inventor: MARTIN KATHLEEN
IPC: C07D265/36
Filed: 2020-04-30
Abstract: L'invention concerne des composés, des compositions et des procédés utiles pour moduler la réponse intégrée au stress (ISR) et pour traiter des maladies, troubles et états associés.
Patent CA-3139643-A1 (CA)
Title: Oncolytic virus with improved safety and anticancer effects
Inventor: HWANG TAEHO
IPC: C12N15/863
Filed: 2020-06-29
Abstract: The present invention relates to an oncolytic virus with improved safety and anticancer effects, and a use thereof. The oncolytic virus with improved safety and anticancer effects according to the present invention can express an HSV-TK fragment which contains an effector domain composed of a minimum amino acid sequence capable of phosphorylating GCV or ACV while having no thymidine kinase (TK) activity, or a variant thereof to phosphorylate GCV or ACV, thereby killing cancer cells infected with the oncolytic virus and even neighboring cancer cells. In addition, GCV or ACV is involved in the suppression of viral proliferation and thus, can regulate virus-induced side effects even upon the administration of a high dose of the virus. Furthermore, an anticancer effect is increased even though the number of viral particles is reduced due to suppression of GCV against viral proliferation. Therefore, the oncolytic virus with improved safety and anticancer effects according to the present invention can be advantageously used for treating cancer.
Patent CA-3141450-A1 (CA)
Title: Reservoir configuration for aerosol delivery device
Inventor: HEJAZI VAHID
IPC: B05B17/06
Filed: 2020-05-20
Abstract: The present disclosure provides an aerosol delivery device that may comprise a housing defining an outer wall. The device may further include a power source and a control component, a mouthpiece portion, a tank portion that includes a reservoir configured to contain a liquid composition, and an atomization assembly configured to vaporize the liquid composition to generate an aerosol. The atomization assembly may comprise a vibrating assembly that includes a mesh plate. In some implementations, the reservoir of the aerosol delivery device may be configured to rotate relative to the position of the aerosol delivery device. In some implementations, the aerosol delivery device may further comprise a perforated gate. In some implementations, the aerosol delivery device may further comprise a liquid transport element. In some implementations, the aerosol deliver device may further comprise a micropump assembly. In some implementations, the reservoir of the aerosol delivery device may be U-shaped.
Patent CA-3141462-A1 (CA)
Inventor: CARPENTER BRIAN SCOTT
IPC: G03G21/16
Filed: 2020-05-22
Abstract: Selon un exemple de la présente invention, une cartouche de toner comprend des premier et second guides d'alignement qui s'étendent vers l'extérieur à partir d'un premier côté et d'un second côté de la cartouche de toner, respectivement, et qui servent à positionner la cartouche de toner. Les premier et second guides d'alignement définissent un axe de pivotement autour duquel la cartouche de toner peut pivoter par rapport à une unité d'imagerie lorsque la cartouche de toner est installée sur l'unité d'imagerie. Un élément de mise en prise est positionné sur une partie arrière de la cartouche de toner pour recevoir une force de sollicitation servant à solliciter la cartouche de toner autour de l'axe de pivot lorsque la cartouche de toner est installée sur l'unité d'imagerie. L'élément de mise en prise est positionné à côté du fond du boîtier. L'élément de mise en prise comprend une surface de contact inclinée qui fait face vers le haut et vers l'arrière de façon à entrer en contact avec un élément de maintien correspondant sur l'unité d'imagerie lorsque la cartouche de toner est installée sur l'unité d'imagerie.
Patent CA-3148746-A1 (CA)
Title: Method and device for reconstructing a backscattered electromagnetic vector wave
Inventor: CALBRIS GAETAN
IPC: G01B11/16
Filed: 2020-07-26
Abstract: The invention relates to a method (1) for reconstructing an electromagnetic vector wave backscattered in all or part of an optical fibre (106), comprising: - a step (200) of injecting a light signal of frequency v0 or v0+vA into the optical fibre (106), - a step (300) of polarisation-resolved optical heterodyne detection comprising the generation of at least two orthogonally polarised backscattered light signals, producing a beat preferably of frequency vA, - a step (400) of converting, by at least one photodetector (203), orthogonally polarised backscattered light signals into initial analogue signals, - a step (500) of electrical homodyne detection, by an IQ demodulator (211, 302), so as to generate demodulated analogue signals I (I1, I2) and Q (Q1, Q2), and - a step (600) of reconstructing, by a processing module (209), the electromagnetic vector wave backscattered in all or part of the optical fibre (106).
Patent CA-3150273-A1 (CA)
Inventor: YU JOHN SUN
IPC: A61K39/00
Filed: 2020-08-10
Abstract: Described herein are compositions and methods for treating cancer and autoimmune diseases.
Patent CA-3153497-A1 (CA)
Inventor: YEO LESLIE
IPC: A61M15/00
Filed: 2020-10-05
Abstract: La présente invention concerne un nébuliseur pour nébuliser des gouttelettes de liquide, comprenant : un boîtier ; au moins un substrat piézoélectrique (2) reçu à l'intérieur du boîtier et ayant une surface de transducteur (2a) sur laquelle est situé au moins un transducteur électroacoustique (48) pour générer une énergie d'onde acoustique à l'intérieur de l'au moins un substrat piézoélectrique (2), et une surface opposée de non-transducteur (2b) ; et un système d'alimentation en liquide pour fournir un liquide à au moins l'une des surfaces de transducteur et de non-transducteur, le système d'alimentation en liquide comprenant un réservoir (3) pour recevoir le liquide, et au moins un conduit d'alimentation (6) relativement rigide en contact avec l'au moins un substrat piézoélectrique (2) ; et un capteur pour détecter un volume de liquide sur l'au moins un substrat piézoélectrique (2).
Patent CA-3154189-A1 (CA)
Title: Constructions d'igf2 variant
Inventor: DO HUNG
IPC: C07K14/65
Filed: 2020-10-12
Abstract: L'invention concerne de nouveaux peptides IGF2, de nouvelles protéines de fusion et de nouvelles séquences d'acides nucléiques codant pour de nouveaux peptides IGF2 et de nouvelles protéines de fusion pour le traitement de troubles de stockage lysosomaux, les peptides IGF2 conférant des propriétés améliorées, telles qu'une expression, une sécrétion et une absorption cellulaire améliorées. Les constructions de l'invention sont utiles dans le traitement de troubles du stockage lysosomaux à la fois par une thérapie de remplacement enzymatique et une thérapie génique.
Patent CA-3156962-A1 (CA)
Inventor: BRIGNAC JACQUES L
IPC: G01N29/04
Filed: 2020-10-29
Abstract: L'invention concerne un appareil de test ultrasonore structuré pour effectuer une inspection ultrasonore sur une pièce à travailler. L'appareil de test ultrasonore comprend une sonde de test ultrasonore structurée pour générer une sortie ultrasonore dirigée vers la pièce à travailler et pour recevoir une entrée ultrasonore à partir de la pièce à travailler qui est sensible à la sortie ; un système de distribution de couplant comprenant une alimentation de couplant, le système de distribution de couplant comprenant en outre un actionneur qui, lorsqu'il est actionné, est structuré pour appliquer à partir de l'alimentation de couplant une quantité d'un couplant à au moins l'une de la pièce à travailler et de la sonde de test ultrasonore ; et un appareil de commande électriquement raccordé à la sonde de test ultrasonore et au système de distribution de couplant, l'appareil de commande étant structuré pour recevoir l'entrée ultrasonore et étant en outre structuré pour faire fonctionner l'actionneur. L'invention concerne en outre un système de distribution de couplant qui peut fonctionner avec un appareil de test ultrasonore qui est structuré pour effectuer une inspection ultrasonore sur une pièce à travailler.
Patent CA-3156998-A1 (CA)
Title: Systems and methods for determining absolute velocity and position of a sensor device for measuring fluid and fluid conduit properties
Inventor: VAN POL ANOUK
IPC: F17D5/02
Filed: 2022-04-29
Abstract: Systems, methods, and devices for fluid conduit inspection using absolute velocity of a sensor device are provided. The method includes: receiving sensor data collected by a sensor device during a measurement run from an interior of the fluid conduit while traveling along a length of the fluid conduit, the sensor device including a first magnetometer and a second magnetometer each having a fixed position in the sensor device, the fixed positions defining a separation distance between the first magnetometer and second magnetometer, the sensor data including magnetic flux data comprising first magnetic flux data collected by the first magnetometer and second magnetic flux data collected by the second magnetometer; determining a time delay between when a magnetic signal is present in the first magnetic flux data and when the magnetic signal is present in the second magnetic flux data; determining an absolute velocity of the sensor device.
Patent CA-3158699-A1 (CA)
Inventor: BOHM BENJAMIN
IPC: B25F5/00
Filed: 2020-11-23
Abstract: A system includes a communications module having a first interface and a second interface. The first interface is on an opposite surface of the communications module from the second interface. The system also includes a battery pack to receive power tool operating information, where the battery pack removably couples with the communications module via the second interface. The battery pack transfers a portion of the power tool operating information and/or a portion of battery pack operating information to the communications module via the second interface. The system also includes a charger module to removably couple with the communications module via the first interface, where the charger module recharges the battery pack through the first and second interfaces of the communications module.
Patent CA-3160058-A1 (CA)
Inventor: KRESS JOCHEN
IPC: B23B31/113
Filed: 2020-12-16
Abstract: The invention relates to a tool part (1) which is designed for connecting to a tool counter-part (3), wherein the tool part (1) has a centring section (5) and an axial stop (7), and wherein the tool part (1) has a plug/twist section (9) which is designed to cooperate with a plug/twist counter-section (11) of the tool counter-part (3) in order to connect the tool part (1) to the tool counter-part (3).
Patent CA-3161755-A1 (CA)
Title: Unmanned aircraft structure evaluation system and method
Inventor: SCHULTZ STEPHEN L
IPC: G08G5/04
Filed: 2015-01-07
Abstract: A computerized method performed by an unmanned aerial vehicle (UAV) comprising: re ce iving a flight plan comprising a plurality of flight capture points, each having a geospatial reference, for a structure having an outline, a first group of points adjacent to a first side of the outline, and a second group of points adjacent to a second side of the outline; conducting an evaluation of the structure comprising:  directing the UAV to fly the plan and capture images while the UAV is at the points, the UAV  having a collision detection and avoidance system to detect an obstruction in the plan and steer the UAV to bypass the obstruction, and aiming a camera at a target capture point on the exterior surface of the structure to capture an image and ensure complete coverage of the structure; and navigating the UAV to another point; and navigating the UAV  to a landing location.
Patent CA-3162538-A1 (CA)
Inventor: KNITTER JERALD WILLIAM
IPC: B65D1/36
Filed: 2020-12-16
Abstract: L'invention concerne un plateau à plusieurs compartiments (10) ayant au moins deux compartiments (12, 14) qui sont reliés au moment de la vente et peuvent ensuite être divisés en compartiments isolés, séparés, par un utilisateur. Les compartiments sont reliés par une région de perforation en forme d'onde tridimensionnelle (24). Chaque onde de perforation (26) comprend une crête (30) et un creux (28) et des pattes de perforation (32, 34) sont formées sur au moins certaines des crêtes et des creux et forment le point d'interconnexion entre les compartiments. Lors de l'utilisation, un utilisateur peut appliquer un effet de levier aux plans décalés, ce qui conduit à une flexion/un encliquetage des compartiments l'un par rapport à l'autre et conduit à provoquer la rupture de perforation, les compartiments étant ainsi séparés.