baber/WOPTO huggingface dataset:
Patent AT-E229839-T1 (AT)
Inventor: SUHR PATRICK
IPC: B01D21/24
Filed: 1999-02-09
Granted: 2003-01-15
Abstract: The invention concerns a device for recuperating floating materials in sedimentation tanks in installations treating effluent water. The invention is characterized in that it is in the form of a rotary syphon implanted above the tank at the end thereof and comprising an immersed discharge pipe, including a longitudinal slot and closed at one end and open at the other, an immersed bucket welded on said discharge pipe, over the whole length thereof, and a gear motor periodically driving in rotation over 360° the discharge pipe bucket assembly such that the floating materials are recuperated at each rotation by said bucket whereof the position relative to the immersed pipe is determined so that the floating materials are discharged into said pipe through its longitudinal slot then evacuated by gravity through said immersed pipe open end.
Patent AT-E231255-T1 (AT)
Inventor: HAAS PETER
IPC: G06F11/34
Filed: 1999-04-28
Granted: 2003-02-15
Abstract: The present invention provides a RISC processor with a debug interface unit that enables the external replication of the data processing sequence within a RISC processor for debug purposes. The data exchanged between the sequence controller and the instruction decoder are intermediately stored and forwarded via a free bus line to an interface unit. In the interface unit, the data pending at its inputs are forwarded to defined outputs of the interface. This allows the register contents to be co-read in real time. Accordingly, all the required information to perform an efficient error search are displayed for an outside operator who may then monitor the data processing sequence and conduct an error search.
Patent AT-E414162-T1 (AT)
Inventor: BERRY ALAN
IPC: C12N15/09
Filed: 1999-07-15
Granted: 2008-11-15
Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
Patent AT-E297427-T1 (AT)
Inventor: TADA YUJI
IPC: C08K5/5399
Filed: 1999-03-11
Granted: 2005-06-15
Abstract: A flame-retardant resin composition comprising a phosphazene flame retardant and a polyester resin, wherein the flame retardant is bonded to the molecules of the polyester resin via the ester group thereof, can retain a high flame retardance for a prolonged term with little or no vaporization with time and is excellent in flame retardance, impact resistance, properties and processability.
Patent AT-E309539-T1 (AT)
Inventor: HOSHINO NOBUHIRO
IPC: G01N33/573
Filed: 1999-08-31
Granted: 2005-11-15
Abstract: This invention relates to a method for immunologically measuring human thymidylate synthase with an anti-human thymidylate synthase antibody, wherein as the antibody, at least an anti-human thymidylate synthase polyclonal antibody immobilized on an insoluble matrix is used; a method for evaluating sensitivity of cancer cells to a fluoropyrimidine antitumor drug from the results of the measurement by the measuring method; and a human thymidylate synthase measuring kit comprising an insoluble matrix with at least one anti-human thymidylate synthase polyclonal antibody immobilized thereon. By a simple immunological measuring method, human TS in a sample can be measured with high sensitivity.
Patent AT-E325146-T1 (AT)
Inventor: NGUYEN KIM SON
IPC: A61K9/32
Filed: 1999-08-25
Granted: 2006-06-15
Abstract: The present invention relates to free-radically polymerizable, siloxane-containing urethane (meth)acrylates which comprise, in incorporated form,a) at least one compound which contains at least one active hydrogen atom and at least one free-radically polymerizable alpha,beta-ethylenically unsaturated double bond per molecule,b) at least one diisocyanate,c) at least one compound which contains two active hydrogen atoms per molecules,d) at least one compound which contains at least one active hydrogen atom and at least one siloxane group per molecule,to water-soluble or water-dispersible polymers which comprise these urethane (meth)acrylates in copolymerized form, to the use of these polymers, and to cosmetic compositions which comprise these polymers.
Patent AT-E334510-T1 (AT)
Inventor: TRAN JIMMY CUONG
IPC: H04B1/7093
Filed: 1999-09-16
Granted: 2006-08-15
Abstract: A multi-clock matched filter for receiving signals with multipath. The signals may be modulated with a spread-spectrum spreading sequence, or other analog or digital signal. A number of signal registers store digital samples of the received signal. The gating of digital samples into each of the signal registers is controlled by a separate clock timing. The timing sequence may be derived from a common clock. A multiplexer sequentially selects each of the signal registers, and passes the respective content of each signal register to a matched filter. A number of delay-locked-loop circuits track each of the multipath signals, and generate the timing sequence for gating signal registers.
Patent AT-E232323-T1 (AT)
Inventor: WADA SATOHARU
IPC: B42D15/10
Filed: 1999-11-04
Granted: 2003-02-15
Abstract: A process for producing an IC card is provided wherein an interlayer sheet carrying an IC module is contact bonded under reduced pressure to a top sheet and a base sheet using a reactive polyurethane hot melt adhesive.
Patent AT-E288673-T1 (AT)
Inventor: BERGSTROEM JOHAN
IPC: H05K/
Filed: 1999-12-22
Granted: 2005-02-15
Abstract: A method of transferring component tape information to a component mounting machine, a tape guide for guiding a component tape in a component mounting machine, and a tape magazine for receiving the tape guide. The tape guide is arranged for quick and ready attachment and detachment into and from the component mounting machine. The loading and/or unloading of a component tape into and from the tape guide can be performed away from the component mounting machine. The ability to be releasably mounted is achieved by providing the tape guide with a lock that enables ready and quick attachment and detachment to an interacting lock in a component mounting machine, or in a tape magazine arranged for insertion into a component mounting machine, and a guide for guiding the component tape. The tape guide further includes an identifier for holding the identity of the tape guide, which can be associated with information relating to the component tape.
Patent AT-E224782-T1 (AT)
Inventor: STREUBEL HANS
IPC: B22D11/04
Filed: 1999-11-04
Granted: 2002-10-15
Abstract: The invention relates to a mould plate of a continuous casting plant. Said mould plate consists of copper and comprises a working surface (2) which faces a metal melt (3) or a (partially) solidified metal strand when the continuous casting plant is in operation and at least one cooling surface (5, 5') which is in contact with a cooling medium when the continuous casting plant is in operation. The mould plate has a heat conductivity (W) and extends over a mould length (L) in the direction of casting (x). According to the invention, a layer (7) with a heat conductivity (S) which is less than the plate heat conductivity (W) of the mould plate is applied to the cooling surface (5, 5') in at least one partial area.
Patent DE-03727511-T1 (DE)
Inventor: MIRA NAVARRO ANGEL
IPC: B65D47/34
Filed: 2003-05-21
Abstract: The valve comprises three parts of generally cylindrical shape, of two or more diameters, fitted into one another, the first of these having a structure of two successive cylinders, being fixed between the cap of the container carrying the substance to be metered and the rim of the neck of the container itself, while the second part is intended to act as main plunger, sliding by its upper portion inside the first part and having a terminal end of smaller diameter guided in the portion of smaller diameter of the first part and having in its intermediate region a likewise intermediate diameter with the main filling and discharge vents for the product, and the third part is formed by a hollow rod rigidly connected to the handle/outlet nozzle and which likewise has a cylindrical structure with two successive different diameters. <IMAGE>
Patent DE-05256886-T1 (DE)
Title: Robotervorrichtung zum Greifen von Zellen und anderen Anwendungen mit integrierter spektroskopischer Kapazität
Inventor: JIANG YONGGANG
IPC: G01N21/64
Filed: 2005-11-07
Abstract: Robotervorrichtung,
welche folgendes umfaßt:  ein
Hauptbett (5), ausgestattet mit einer Abbildungsstation (100), wobei
ein eine Probe enthaltender Probenbehälter (10) in einer Objektposition
angeordnet werden kann, und  einen Kopf (118) mit zugehörigem Positionierungssystem (98),
welcher oberhalb des Hauptbetts der Vorrichtung montiert ist und
dadurch gekennzeichnet ist, daß er
weiterhin folgendes umfaßt:  optische
Teilsysteme (110) für
die Anregung und Erfassung, die unterhalb des Hauptbetts der Vorrichtung
montiert sind und so angeordnet sind, daß sie die Objektposition von
unten anregen und Licht von dieser erfassen.
Patent DE-09812049-T1 (DE)
Title: Impulsartiger elektrogesteinsbohrer mit nichtrotierender bohrspitze und direktionaler steuerung
IPC: E21B7/15
Filed: 2009-08-26
Abstract: Ein Bohrgerät mit getaktetem Strom zum Durchleiten eines getakteten elektrischen Stroms durch ein Substrat zum Brechen des Substrats, wobei das Gerät folgendes umfasst: einen elektrobrechenden Bohrer, umfassend eine nicht-rotierende Bohrspitze; einen getakteten Stromerzeuger, der mit der nicht-rotierenden Bohrspitze zum Abgeben von Hochspannungsimpulsen verbunden ist; und mindestens einen Satz von zwei Elektroden, angeordnet an der nicht-rotierenden Bohrspitze, wobei der mindestens eine Satz von zwei Elektroden für eine Richtungssteuerung der nicht-rotierenden Bohrspitze sorgt.
Patent DE-09829577-T1 (DE)
Title: Azeotrope zusammensetzungen mit 1-chlor-3,3,3-trifluorpropen
Inventor: SINGH RAJIV R
IPC: C09K23/00
Filed: 2009-10-27
Abstract: Zusammensetzung, umfassend eine binäre azeotropähnliche Mischung bestehend im Wesentlichen aus 1-Chlor-3,3,3-trifluorpropen und einem C1-C3-Alkohol, ausgewählt aus der Gruppe bestehend aus Methanol, Ethanol und Isopropanol.
Patent DE-31286-T1 (DE)
IPC: B21F33/00
Filed: 1980-12-19
Abstract: Simple twist wire net of the type in which adjacent rows can pivot relative to each other is folded, accordian fashion, by depositing the net onto at least two elongated, spaced apart, parallel supports. The supports are spaced apart a distance equal to a multiple of the distance between interlooped peaks and valleys of adjacent rows of the net, and engage the underside of the peaks and valleys to permit the net to fold by gravity on the supports and to maintain the peaks and valleys aligned. The supports can be rigid beams or drivable strands to fold and store the net, and the folded net can be formed into a compact roll.
Patent DE-139775-T1 (DE)
IPC: B65G47/26
Filed: 1983-10-20
Abstract: In an article conveying and accumulating device, in which substantially identical articles (A) are being transferred by a pusher (2) from a conveyor (1) onto a receiving surface (C) adjacent the conveyor (1), and accumulated on said receiving surface (C) by repeated strokes of said pusher (2), the receiving surface (C) is formed by a conveyor (5) driven for constant movement at right angles to the conveyor (1) with substantially the same speed as the pushing speed of the pusher (2). The receiving conveyor is composed of two chains (5) and freely rotatable support rods (6) extending there between.
Patent DE-128837-T1 (DE)
IPC: B60R13/06
Filed: 1984-06-08
Abstract: 1. A glass pane ready for fitting in a rigid frame (2), more particularly for motor vehicles, the pane having on its inside surface (1_a) a plastic cord or tape or the like (6, 26, 36) heatable electrically through Joule effect by means of an electrically resistive metal element associated with the cord or tape or the like and thus to be secured to the rigid frame (2) by sticking, the pane having right around its periphery (3) a flexible plastics finishing seal (4, 20, 30, 31) having on its surface remote from such periphery means (8, 32) for providing a sealing connection with the frame (2) and for compensating for dimensional differences between the same and the pane, characterised in that the finishing seal (4, 20, 30, 31) covers some of the pane inside surface (1_a), the cord or tape or the like (6, 26, 36) is disposed in contact with the seal (4, 20, 30, 31) and the electrically resistive metal element (7, 20) ist embedded partly in the seal (4, 20, 30, 31) and partly in the cord (6, 26, 36) to enable heating.
Patent DE-790952-T1 (DE)
Inventor: BAGNATO LUIGI
IPC: B65H18/26
Filed: 1995-08-11
Abstract: A winder in a papermaking machine has a frame with horizontal rails which are positioned above a rotatable reel support drum, which is fixedly mounted. As a relatively large diameter wound paper web reel, or jumbo, is formed on a spool riding on the rails, the surface of the jumbo remains tangent to the top of the support drum as the spool moves from an initial position vertically over the reel drum to a position laterally displaced horizontally along the rail. Centerwind drive(s) control spool torque. As the jumbo increases in size, it is moved linearly away from the initial position, while maintaining the paper web reel rotatively supported and in a nipping engagement with the support drum. Nip pressure between the support drum and the jumbo is controlled by the force of gravity and the horizontal positioning of the jumbo along the rails. The positioning of the jumbo along the rail may be controlled by a conventional pneumatic or hydraulic cylinder, or a screw mechanism. An alternative embodiment winder utilizes primary and secondary arms to position the jumbo and its spool along the reel rails.
Patent DE-773441-T1 (DE)
Inventor: RUOSLAHTI ERKKI I
IPC: A61K47/48
Filed: 1996-09-10
Abstract: The present invention provides an  in vivo  method for identifying molecules that home to a selected organ or tissue. In addition, the invention provides peptides that home to a selected organ or tissue. For example, the invention provides peptides that selectively home to an organ such as brain or kidney or to a tissue such as a tumor tissue. The invention further provides methods of using an organ homing molecules, for example, to target an agent such as a drug to a selected organ or to identify the target molecule expressed by the selected organ.
Patent DE-1030820-T1 (DE)
Inventor: AUDIC JEAN-MARC
IPC: C02F3/00
Filed: 1998-06-15
Abstract: The oxidoreduction potential is measured on each of a number of tanks. A data processing system analyzes the oxidoreduction potential evolution and establishes a diagnosis of the aeration/biology couple to ensure the degradation reactions of the carbonaceous and nitrogenous pollution. It is then determined whether to start, to continue, or to stop aeration in the tanks, depending on the required degree of purification. In the first tanks, priority is given to the treatment of carbonaceous pollution with specific parameter representation of the oxidoreduction potential threshold values. In the last tank, fine-tuning the treatment of the carbonaceous and nitrogenous pollution is accomplished by managing the aeration.
Patent ES-2224903-T1 (ES)
Title: Estructura de construccion, procedimiento y dispositivo para fabricar dicha estructura de construccion.
Inventor: GRAEVENITZ ALEXANDR ALEXANDROV
IPC: B28B21/64
Filed: 2002-06-07
Abstract: Método para producir una estructura de construcción de una composición endurecible y fibras, que comprende aplicar al menos una capa de composición endurecible y una capa de fibras sobre un mandril giratorio con la repetición de las etapas anteriormente mencionadas al tiempo que se aplican las capas sucesivas, secar y retirar el producto final a partir del mandril, caracterizado porque las fibras se aplican a un tejido celular prefabricado en toda la altura del mandril, siendo aplicada la composición endurecible perpendicularmente a la dirección de la aplicación de las fibras.
Patent ES-2254047-T1 (ES)
Title: Procedimiento de preparacion de derivados de topiramato anticonvulsivos.
Inventor: BERKNER JOACHIM ERNST
IPC: C07H5/06
Filed: 2004-03-02
Abstract: Un procedimiento para la preparación de un compuesto de fórmula (I) donde: X se selecciona entre CH2 y O; R1 se selecciona del grupo que consiste en hidrógeno y alquilo de C1-4; R3, R4, R5 y R6, se seleccionan cada uno independientemente entre hidrógeno y alquilo inferior y, cuando X es CH2, R5 y R6 puede consistir en grupos alqueno unidos para formar un anillo de benceno y, cuando X es O, R3 y R4 y/o R5 y R6, juntos, pueden ser grupo metilendioxi de la fórmula: donde R7 y R8 son iguales o diferentes y son hidrógeno, alquilo inferior o son alquilo y se unen para formar un anillo ciclopentilo o ciclohexilo; que comprende la reacción de un compuesto de fórmula (II) con sulfuril diamida, a temperatura elevada, en presencia de 0 a aproximadamente 10% de agua, para dar el correspondiente compuesto de fórmula (I).
Patent ES-2040692-T1 (ES)
Title: Un sistema de telecomunicacion.
IPC: H04L12/54
Filed: 1990-02-23
Abstract: SE PRESENTA UN SISTEMA DE TELECOMUNICACIONES PARA INTERCONECTAR UNA PLURALIDAD DE LINEAS DE COMUNICACION TELEFONICA A UNA RED DE TRANSMISIONES. EL SISTEMA INCLUYE MEDIOS DE TRANSMISION EN AL MENOS UN PRIMER EXTREMO DE LA RED DE TRANSMISION QUE INCLUYE: UN APARATO PARA DETECTAR LAS SEÑALES DE FACSIMIL SOBRE LA PLURALIDAD DE LAS LINEAS DE TELECOMUNICACION TELEFONICA; UN APARATO PARA DEMODULAR LAS SEÑALES DE FACSIMIL; UN APARATO PARA TRANSMITIR A LO LARGO DE LA RED DE TRANSMISION, EN FORMA DEMODULADA, LA SALIDA DE LAS SEÑALES DE FACSIMIL DEL APARATO PARA DEMODULAR; Y UN APARATO RECEPTOR EN AL MENOS UN SEGUNDO EXTREMO DE LA RED DE TRANSMISION QUE INCLUYE UN APARATO PARA MODULAR DICHAS SEÑALES DE FACSIMIL RECIBIDAS A LO LARGO DE LA RED DE TRANSMISION.
Patent ES-2091733-T1 (ES)
Title: Producto y procedimiento para el teñido oxidativo del cabello.
Inventor: MAGER HERBERT DR
IPC: A61K8/41
Filed: 1995-10-14
Abstract: COMPUESTO PARA LA COLORACION OXIDATIVA DE LOS CABELLOS, QUE SE OBTIENE MEZCLANDO UN PORTADOR DE COLORANTE CON UN OXIDANTE JUSTO ANTES DE SU UTILIZACION. TIENE UN PH MAS PEQUEÑO QUE 8 Y UNA COMBINACION DE GENERADOR/ACOPLADOR, UTILIZANDO COMO GENERADOR 2(2,5-DIAMINOFENIL)-ETANOL O SUS SALES SOLUBLES EN AGUA FISIOLOGICAMENTE ACEPTABLES. EL COMPUESTO TIENE BUENAS PROPIEDADES PARA COLOREAR, DANDO UNA COLORACION UNIFORME DE LOS CABELLOS DESDE LAS RAICES A LAS PUNTAS.
Patent ES-2142782-T1 (ES)
Inventor: ROWLAND BARRY
IPC: C11D3/37
Filed: 1998-08-03
Abstract: The present invention provides a detergent tablet comprising:     a) a compressed portion comprising active detergent components; b) a non compressed, non-encapsulating portion comprising active detergent components. Detergent components which are sensitive to compression can be incorporated into tablets and greater control of washing processes can be achieved.
Patent CY-1110483-T1 (CY)
Inventor: SCHULTZ PETER G
IPC: C12P21/02
Filed: 2009-06-24
Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
Patent CY-1111831-T1 (CY)
Title: Παραγωγα ογκο-συναφους αντιγονου απο την οικογενεια mage και αλληλουχιες νουκλεϊνικου οξεος που κωδικοποιουν αυτα, που χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο
Inventor: CABEZON SILVA TERESA
IPC: C12N15/70
Filed: 2011-09-14
Abstract: Η παρούσα εφεύρεση αφορά νέες πρωτεΐνες και παρασκευή αυτών, από την οικογένεια MAGE. Ιδιαιτέρως, μια πρωτεΐνη MAGE που συντήκεται προς ανοσολογικό συνεργάτη σύντηξης, όπως Λιποπρωτεΐνη D. Τέτοια αντιγόνα μπορεί να συνταγοποιούνται για να παρέχουν εμβόλια για την θεραπεία μιας περιοχής όγκων. Παρέχονται επίσης νέοι μέθοδοι καθαρισμού πρωτεϊνών MAGE.
Patent CY-1114060-T1 (CY)
Title: Φαρμακευτικες μορφες δοσολογιας
Inventor: MANNION RICHARD OWEN
IPC: A61K9/22
Filed: 2013-06-18
Abstract: Η παρούσα εφεύρεση αναφέρεται σε φαρμακευτικές μορφές δοσολογίας, για παράδειγμα σε μία απαραβίαστη μορφή δοσολογίας περιλαμβάνουσα ένα οπιούχο αναλγητικό, και σε μεθόδους παραγωγής, χρήσεις και μεθόδους αγωγής του.
Patent CY-1116137-T1 (CY)
Title: Χρηση των αναστολεων il-18 σε διαταραχες υπερευαισθησιας
Inventor: CHVATCHKO YOLANDE
IPC: A61K39/00
Filed: 2015-03-23
Abstract: Η εφεύρεση αφορά στη χρήση αναστολέων της IL-18 στην παρασκευή ενός φαρμάκου για θεραπεία ή/και πρόληψη διαταραχών υπερευαισθησίας και ιδιαιτέρως υπερευαισθησίας καθυστερημένου-τύπου.
Patent CY-1116191-T1 (CY)
Title: Παραγωγα πυριδαζινονης
Inventor: STIEBER FRANK
IPC: C07D405/14
Filed: 2015-04-09
Abstract: Ενώσεις του τύπου (I), στον οποίον Υ, R1, R2, R3 και R3' έχουν τις σημασίες που δίδονται στην αξίωση 1, είναι αναστολείς των κινασών τυροσίνης, ειδικότερα της Met-κινάσης και μπορούν μεταξύ άλλων να χρησιμοποιηθούν για τη θεραπεία όγκων.
Patent CY-1117581-T1 (CY)
Title: Ηλεκτρομηχανικη διαταξη σεξουαλικης διεγερσεως
Inventor: MURISON BRUCE
IPC: A61H23/02
Filed: 2016-06-01
Abstract: Μία διάταξη για χρήση από μία γυναίκα για σεξουαλική διέγερση η οποία περιλαμβάνει έναν εσωτερικό βραχίονα διαστασιολογημένο για εισαγωγή εντός ενός κόλπου, προκειμένου να έρχεται σε επαφή με το τοίχωμα του κόλπου στο σημείο G ή πλησίον αυτού, έναν εξωτερικό βραχίονα διαστασιολογημένο για να έρχεται σε επαφή με την κλειτορίδα, και ένα ελαστικό στέλεχος σχήματος U το οποίο συνδέει τον εσωτερικό και τον εξωτερικό βραχίονα.
Patent CY-1117776-T1 (CY)
Title: Εναντιομερη ενωσεων σπειρο-οξινδολιου και οι χρησεις τους ως θεραπευτικοι παραγοντες
Inventor: CHAFEEV MIKHAIL
IPC: A61K31/404
Filed: 2016-06-28
Abstract: Η εφεύρεση αυτή εστιάζεται στο (S)-εναντιομερές της ένωσης του τύπου (I) ή ένα φαρμακευτικώς αποδεκτό επιδιαλύτωμα ή προφάρμακο αυτής. Αυτό το (S)-εναντιομερές είναι χρήσιμο για την αντιμετώπιση νόσων ή παθήσεων, όπως πόνου, οι οποίες βελτιώνονται ή μετριάζονται με τη ρύθμιση ελεγχόμενων από τάση διαύλων νατρίου.
Patent CY-1122314-T1 (CY)
Title: Κυκλοπροπυλαμινες ως αναστολεις lsd1
Inventor: ZHANG FENGLEI
IPC: C07D211/98
Filed: 2019-11-21
Abstract: Η παρούσα εφεύρεση κατευθύνεται σε παράγωγα κυκλοπροπυλαμίνης που είναι αναστολείς LSD1 χρήσιμοι στη θεραπεία ασθενειών όπως καρκίνου.
Patent CY-1123676-T1 (CY)
Title: Συνθεσεις και μεθοδοι για την εσωτερικοποιηση ενζυμων
Inventor: BAIK ANDREW
IPC: A61K38/47
Filed: 2020-12-22
Abstract: Αποκαλύπτονται συνθέσεις και μέθοδοι για τη θεραπευτική αντιμετώπιση νόσων λυσοσωμικής αποθήκευσης. Επίσης αποκαλύπτονται βιοθεραπευτικά σύμπλοκα που περιέχουν ένα τομέα δέσμευσης τελεστή εσωτερικοποίησης και δραστικότητα λυσοσωμικού ενζύμου αντικατάστασης. Τα βιοθεραπευτικά σύμπλοκα είναι ικανά να εισέλθουν σε κύτταρα, να απομονωθούν στο λυσόσωμα και να παραδώσουν τη δραστικότητα του ενζύμου αντικατάστασης στο λυσόσωμα.
Patent CY-1124232-T1 (CY)
Title: Συνδετικα μορια συνδεσης pd-l1 και lag-3
Inventor: CAMPBELL JAMIE
IPC: C07K16/28
Filed: 2021-04-13
Abstract: Η παρούσα αποκάλυψη αφορά σε μόρια αντισώματος που συνδέονται προς προγραμματισμένου θανάτου-προσδέτη 1 (PD-L1) και γονίδιο 3 ενεργοποίησης λεμφοκυττάρου (LAG-3). Τα μόρια αντισώματος κατά προτίμηση περιλαμβάνουν CDR-βασιζόμενη θέση σύνδεσης αντιγόνου για PD-L1, και θέση σύνδεσης αντιγόνου LAG-3 που μπορεί να είναι τοποθετημένη σε δύο ή περισσότερους δομικούς βρόχους ενός CH3 πεδίου του μορίου αντισώματος. Τα μόρια αντισώματος της αποκάλυψης βρίσκουν εφαρμογή, για παράδειγμα, στη θεραπεία καρκίνου.