Patent WO-2012034932-A1 (WO)
Title: Use of specific bis(biphenyl)triazine derivatives and mixtures thereof as uv absorbers
Inventor: WAGNER BARBARA
IPC: A61K8/49
Filed: 2011-09-09
Abstract: Disclosed is the use of mixtures comprising at least 2 structurally different bis(biphenyl)triazine derivatives of formula (1) wherein X is hydrogen; C 1 -C 50 alkyl which may be uninterrupted or interrupted by one or more oxygen atoms and/or substituted by one or more R 8  groups; C 3 -C 12 -cycloalkyl which is substituted by R 8 ; -CH((CH 2 ) p -R 8 )-CO-0-(CH 2 ) m -R 9 ; -CH((CH 2 ) p -R 8 )-CO-(NR 10 )-(CH 2 ) m -R 9 ; (a); (b); -CO-(CH 2 ) p -R 8 ; -CO-O-(CH 2 ) p -R 8 ; -CH 2 -CH(-O(CO)-R 8 )-R 9 ; -CO-(NR 10 )-(CH 2 ) P -R 8 ; C 6 -C 20 aryl; allyl; C 4 -C 50 alkenyl which is uninterrupted or is interrupted by one or more oxygen atoms; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 alkynyl; C 6 -C 12 cycloalkynyl; R 1  is hydrogen; unsubstituted or substituted C 1 -C 12 alkyl; unsubstituted or substituted C 3 -C 12 cycloalkyl; unsubstituted or substituted C 6 -C 20 aryl; unsubstituted or substituted C 2 -C 20 alkenyl; OR 7 ; OH; SR 8 ; SOR 7 ; SO 2 R 7 ; SO 3 H; SO 3 M; or a radical of the formula (c); R 2 , R 3 , R 4 , R 5  and R 6  independently of one another are hydrogen; hydroxyl; -CN; substituted or unsubstituted C 1 -C 20 alkyl; unsubstituted or substituted C 3 -C 12 -cycloalkyl; unsubstituted or substituted C 1 -C 18 alkoxy; unsubstituted or substituted C 4 -C 20 cycloalkoxy; C 7 -C 20 phenylalkyl; halogen; halo-C 1 -C 5 alkyl; sulfonyl; carboxyl; acylamino; acyloxy; C 1 -C 12 alkoxycarbonyl; aminocarbonyl; R 7  is substituted or unsubstituted C 1 -C 18 alkyl; unsubstituted or substituted C 3 -C 12 - cycloalkyl; unsubstituted or substituted C 6 -C 20 aryl; unsubstituted or substituted C 2 -C 20 alkenyl; or C 7 -C 20 phenylalkyl; M is alkali metal; R 8  and R 9  independently of one another are R x  if attached to a carbon atom and are R y  if attached to an oxygen atom; p is 0 to 20; m is 0 to 20; R x  is hydrogen; hydroxyl; C 1 -C 30 alkyl; C 3 -C 12 cycloalkyl; C 1 -C 30 alkoxy; C 3 -C 12 cycloalkoxy; C 3 -C 12 cycloalkyl or C 3 -C 12 cycloalkoxy which is interrupted by one or more oxygen atoms; C 6 -C 12 aryl; hetero-C 3 -C 12 aryl; -OR z ; NHR Z ; R z ; CONR 10 R 11 ; SO 3 H; SO 3 M; OSO 3 H 2 ; allyl, C 2 -C 30 alkenyl; C 4 -C 12 -cycloalkenyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 -alkynyl; or C 6 -C 12 cycloalkynyl; R y  is hydrogen; C 1 -C 30 alkyl; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 6 -C 12 aryl; hetero-C 3 -C 12 aryl; R z ; allyl, C 2 -C 30 alkenyl; C 4 -C 12 -cycloalkenyl which is uninterrupted or interrupted by one or more oxygen atoms; C 3 -C 20 -alkynyl; or C 6 -C 12 cycloalkynyl; R z  is -COR 10 ; -COOR 10 ; -CONR 10 R 11 ; -CO-CH=CH 2 ; -CO-C(CH 3 )=CH 2 ; R 10  and R 11  independently of one another are hydrogen; C 1 -C 30 alkyl; C 1 -C 50 alkyl which is interrupted by one or more oxygen atoms; C 3 -C 12 cycloalkyl which is uninterrupted or interrupted by one or more oxygen atoms; C 2 -C 20 alkenyl which is uninterrupted or is interrupted by one or more oxygen atoms; or C 6 -C 12 aryl; or R 10  and R 11  together form a five or six membered ring; as UV absorbers for increasing the UVA protection factor of cosmetic or dermatological compositions.