baber/WOPTO huggingface dataset:
Patent EP-2274016-B1 (EP)
Title: Variantes de l'igf-i pegylées pour utilisation dans le traitement des troubles neuromusculaires
Inventor: HOLTMANN BETTINA
IPC: A61P25/00
Filed: 2009-03-24
Granted: 2012-07-25
Abstract: La présente invention porte sur l'utilisation pharmaceutique de variants de IGF-I modifiés par du polyéthylène glycol, à savoir PEGylés, destinés à traiter, prévenir et/ou retarder la progression de troubles neuromusculaires, en particulier de la sclérose latérale amyotrophique (ALS). Plus spécifiquement, la présente invention porte sur l'utilisation d'un variant de IGF-I PEGylé pour fabriquer une composition pharmaceutique destinée à traiter, prévenir et/ou retarder des troubles neuromusculaires, en particulier l'ALS. Le variant de IGF-I PEGylé est caractérisé en ce qu'il est issu de la séquence d'acides aminés IGF-I humaine de type sauvage (SEQ ID NO : 1) et porte une ou deux altérations d'acides aminés en positions d'acides aminés 27, 65 et 68, de telle sorte qu'un ou deux des acides aminés en positions 27, 65 et 68 sont un acide aminé polaire mais pas la lysine et que PEG est fixé à au moins un résidu lysine.
Patent EP-2251848-B1 (EP)
Inventor: ASAHARA NOBUAKI
IPC: B60R16/03
Filed: 2009-01-09
Granted: 2012-02-15
Abstract: A system and the like capable of reporting a position of a vehicle to outside at an appropriate frequency, while saving communication cost is provided. According to a vehicle state management system 10 of the present invention, after an IGN switch 101 of a vehicle 1 is switched from ON to OFF, the vehicle state management system 10 is transited from an operating state to a stand-by state. Then, in the case where a transition requirement of the vehicle state management system 10 to a sleeping state is satisfied, a wireless communication equipment 14 transmits a position signal to a vehicle management center 2, and thereafter a vehicle state reporting system 10 is transited to the sleeping state.
Patent EP-2358245-B1 (EP)
Inventor: TANJA AGE WILLEM
IPC: A47J31/42
Filed: 2009-11-23
Granted: 2013-01-02
Abstract: A system (1) for dosing coffee beans, comprising a coffee bean package (2) provided with walls (8,8a) enclosing an inner space for coffee beans, a coffee bean outlet (7) for delivering coffee beans, and a coupling part (12,13) for coupling and uncoupling the coffee bean package with an apparatus that is provided with a coffee bean grinder (4), and an at least partly movably arranged coffee bean receiving device (14) for supplying coffee beans from the coffee bean package (2) to the grinder (4), which coffee bean receiving device (14) is provided with a dosing space (18) for being capable of containing a predetermined dose of coffee beans, wherein the coffee bean package (2) prior to use in itself is closed off such that exposure of the coffee beans to ambient air is prevented, and the coffee bean receiving device (14) is arranged to be guided through the coffee bean outlet (7) into the inner space of the coffee bean package (2) for letting coffee beans from the coffee bean package into the dosing space (18), and to guide the dosing space through the coffee bean outlet (17) out of the inner space of the coffee bean package (2) for supplying the dose of coffee beans from the dosing space (18) to the grinder (4).
Patent EP-2226905-B1 (EP)
Inventor: MAZZULLO RAYMOND
IPC: H01R13/453
Filed: 2010-03-01
Granted: 2012-05-09
Abstract: A power supply system (10) is disclosed in which Schuko sockets (18.1,18.2,18.3,18.4,18.5,18.6) are mounted in back-to-back pairs with units between them which provide receptacles (92) for the pins of Schuko plugs. Each unit comprises a moulding (32) of synthetic plastics material which is in the form of a loop with a crossbar (42) dividing the area within the loop into two spaces. Pairs of electrical receptacles are provided in these spaces, one pair of receptacles being neutral and the other being live. The sockets are offset with respect to one another so that the pins of a Schuko plug inserted into one socket of a back-to-back pair enter one neutral and one live receptacle, and the pins of a second Schuko plug being inserted into the other of the back-to-back sockets enters the other neutral receptacle and the other live receptacle.
Patent EP-2213255-B1 (EP)
Inventor: PODHAJSKY RONALD J
IPC: A61B18/12
Filed: 2010-01-12
Granted: 2012-03-07
Abstract: A device for controlling energy applied to tissue as a function of at least one detected tissue property includes the initial step of applying energy to tissue. The device also includes the steps of initially adjusting the energy applied to tissue and determining a direction of change of the at least one detected tissue property. The device also includes the steps of subsequently adjusting the energy applied to tissue in the same direction as the initially adjusting step if the at least one detected tissue property is changing in a first direction and in the opposite direction to the initially adjusting step if the at least one detected tissue property is changing in a second direction and further adjusting the energy applied to the tissue in the same direction as the initially adjusting step if the at least one detected tissue property is changing in the second direction and in the opposite direction to the initially adjusting step if the at least one detected tissue property is changing in the first direction.
Patent EP-2315071-B1 (EP)
Inventor: NAKAZONO TAKUYA
IPC: G02F1/133
Filed: 2010-09-10
Granted: 2011-10-26
Abstract: The present invention provides a method and a system (1) for continuously manufacturing liquid-crystal display elements, using a continuous optical film laminate (15) which comprises at least an optically functional film (11) having an adhesive layer (12) provided thereon and a carrier film (13) releasably laminated on said adhesive layer (12), the optically functional film (11) including at least one defect-free region (Xa) and at least one defect-containing region (Xp), the defect-free region having a predefined length corresponding to a dimension of a liquid-crystal panel, the defect-containing region including at least one defect and defined as a region having a predefined length which is different from the length of the defect-free region, slit lines (16) being sequentially formed to extend in a transverse direction of the optical film laminate to form defect-free, normal optically functional film sheets and defect-containing optically functional film sheets, the normal optically functional film sheet and the defect-containing optically functional film sheet corresponding to respective ones of the regions in the optically functional film. The optical film laminate including the carrier film is wound into a rall. In manufacturing the liquid-crystal display elements, only the defect-free, normal sheets are laminated to respective ones of the liquid-crystal panels.
Patent EP-2323331-B1 (EP)
Inventor: KO WOO SUK
IPC: H04L27/26
Filed: 2009-06-03
Granted: 2016-10-19
Abstract: The present invention relates to method of transmitting and receiving signals and a corresponding apparatus. One aspect of the present invention relates to a method of receiving a signal, which includes interleaving in an appropriate manner for a channel bonding system. The interleaving can allow decoding a user requested service at a random tuner window position.
Patent EP-2343144-B1 (EP)
Inventor: HAIMER FRANZ
IPC: B23B31/107
Filed: 2007-04-05
Granted: 2019-01-09
Abstract: The holder (1) has a tool holding fixture, preferably a chuck, where a shank of a tool particularly rotary tool, is accommodated in the tool holding fixture. The pull-out preventing unit has a locking element and a locking groove (13), which corresponds to the locking element, receives the locking element and interacts with the locking element in a positively locking manner.
Patent EP-2511160-B1 (EP)
Inventor: LEUDTS THORSTEN
IPC: B62D25/08
Filed: 2011-04-05
Granted: 2013-06-05
Abstract: The invention relates to a front unit (100) for a vehicle, the vehicle comprising at least two pairs of longitudinal beams (108), wherein the front unit (100) comprises an upper an a lower bumper support (102) and two bearers interconnecting the upper and lower bumper support (102), wherein each bearer is attached to a plate (106), each plate (106) being attachable to the distal ends of two of the longitudinal beams (108), wherein the bearers are adapted as shock absorbers in case of a vehicle crash, wherein the front unit (100) further comprises an angular flexible belt (112) interconnecting the bearers.
Patent EP-2529850-B1 (EP)
Inventor: JANSON MARC
IPC: B21D5/02
Filed: 2011-05-30
Granted: 2013-09-11
Abstract: The bending angle sensor (100) has housing (10) with elongate recess (11) in which sliding block is guided in resiliently mounted manner. A limitation portion (14) is provided at one end of housing, for sensing disc to be received in housing. The sliding block is designed to act on one end of to-be-received sensing disc. A position detector (16) is provided in housing, for detecting displacement of sliding block. An independent claim is included for method for measuring bending angle.
Patent EP-2444085-B1 (EP)
Inventor: SAWYERS CHARLES L
IPC: C07D403/10
Filed: 2006-03-29
Granted: 2015-03-18
Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Patent EP-0026175-B1 (EP)
IPC: B60R16/04
Filed: 1980-09-24
Granted: 1983-07-20
Abstract: An adjustable apparatus (15) for rigidly restraining different size objects (10) such as batteries which are resting on a frame (12), such as that of a lift truck vehicle (13). The apparatus has opposed first and second support members (16, 17) upwardly rising from the frame. The rigid first strap structure (20) is pivotally attached (22) to the first support member, while a rigid second strap structure (29) is releasably attached (31 or 31') to the second support member. The strap structures are telescopable (49) one within the other to selectively adjust the length defined by the straps.
Patent EP-0023013-B1 (EP)
IPC: C03C3/04
Filed: 1980-07-15
Granted: 1982-07-14
Abstract: A calcium aluminum fluorosilicate glass powder is disclosed which has average particle size of at least 0.5 microns, and is characterized in that the calcium in the surface of the powder's particles is depleted so that the quotient of the atomic ratio Si/Ca at the surface of the particles and the atomic ratio Si/Ca in the core region of the particles is at least 2.0, more preferably at least 3.0 and most preferably at least 4.0. The glass powder may be prepared by surface treating calcium aluminum fluorosilicate glass powder particles with an acid which forms calcium salts, washing the calcium salts off the treated particles and drying the washed particles. The glass powder has utility in self-hardening glass ionomer cements, such as dental or bone cements. Cements formed from the glass powder exhibit reduced periods of water sensitivity, while permitting sufficient time for processing.
Patent EP-0027258-B1 (EP)
Title: Phosphoryl muramyl peptides, method for their preparation and their use in medicines
IPC: C07H15/04
Filed: 1980-10-09
Granted: 1985-05-15
Abstract: Phosphorylmuramyl peptides of the formula   <IMAGE>   are immuno-potentiating. In the formula, R1 represents optionally substituted alkyl or aryl, R2, R4, R6 and R7 represent, for example, hydrogen, R3 represents hydrogen or lower alkyl, R5 represents, for example, hydrogen, lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl or aralkyl, or nitrogen-containing heterocyclyl or heterocyclyl-lower alkyl, and one of the radicals A1 and A2 represents a radical of the formula (II) <IMAGE> (II)  In the formula (II), T represents NH or O, Y represents an optionally substituted alkylene group, which may also be interrupted by one or two oxycarbonyl and/or iminocarbonyl groups, and W represents an aliphatic radical or a cycloalkyl or cycloalkenyl radical having more than 6 carbon atoms. The other of the radicals A1 and A2 represents free or etherified hydroxy, amino, lower alkylamino or aminocarbonyl-lower alkylamino.
Patent EP-0023839-B1 (EP)
IPC: D21D5/02
Filed: 1980-08-05
Granted: 1984-04-18
Abstract: A pressurized screen particularly adapted for screening paper making pulp includes a cylindrical screen plate mounted in a cylindrical casing and defining with it an annular chamber which receives unscreened pulp from which rejects are removed as the good pulp passes from the annular chamber through the screen plate. The axes of the screen plate and the casing are offset with respect to each other, forming an enlargement of the chamber which extends approximately from an inlet into the annular chamber to a rejects outlet which is diametrically opposite the inlet. A partition in the chamber extends parallel to the axes of the casing and screen plate from a position opposite the inlet to a position above the rejects outlet. The partition is spaced from the opposing inner and outer surfaces of the screen and casing, respectively, and a baffle is provided which extends co-extensively with the partition and slopes helically downwardly about the screen plate from the inlet to the rejects outlet and defines with the partition, the screen plate and a floor of the chamber, a passage of decreasing cross-sectional area. Inlets are also provided for adding dilution liquid to the passage upstream of the rejects outlet and a purging liquid just upstream of the rejects outlet.
Patent EP-0030425-B1 (EP)
IPC: E21B43/27
Filed: 1980-11-21
Granted: 1984-07-11
Abstract: Precipitation of salts such as barium and calcium sulfates is prevented in subsurface oil field formations or in streams of flowing oil which entrains water by adding emulsified, oil-soluble polymeric compositions.
Patent EP-0022738-B1 (EP)
IPC: B28C5/00
Filed: 1980-06-17
Granted: 1982-06-16
Abstract: A process of producing a colloidal mortar suitable for use as a lining of steel conduit pipes, boilers or the like, includes filling a mixer with water while imparting to water a rotary motion by a rotary agitator at a speed of 1500 m/minutes, feeding the mixer with cement while maintaining the rotary motion whereby the mixture forms a funnel-like profile within the mixer and adding to the mixture wet sand of humidity of 5-15% and in proportion of 1 to 2 parts of the cement content to obtain the colloidal mortar. Fiber rovings may be added to the colloidal mortar.
Patent EP-0039734-B1 (EP)
Title: Procede de formation de traitements catadioptriques sur les tissus
IPC: D06M15/00
Filed: 1980-10-14
Granted: 1985-06-05
Abstract: Compositions de revetement pour l'enduisage de tissus de sorte a les rendre brillamment catadioptriques pendant la nuit avec un changement minime de leur aspect a la lumiere du jour ordinaire. Les compositions comprennent un vehicule dilue de revetement, de preference une emulsion aqueuse d'un polymere de base acrylique, et des microspheres transparentes catadioptriques dispersees dans le vehicule. Le vehicule est dilue avec au moins 40% en volume d'un constituant volatile, et les microspheres representent environ un tiers ou moins du volume de la partie non volatile de la composition. Lorsqu'un tissu (10) est enduit de cette composition les microspheres catadioptriques (12) s'eparpillent a faible densite sur la surface du tissu, se logeant souvent dans des evidements (13) de la surface du tissu, et adherent au tissu grace a un materiau liant (11) dans le vehicule de revetement.
Patent EP-0054635-B1 (EP)
Title: Protective solution for heart and kidney, and manufacturing process
IPC: A61K33/14
Filed: 1981-10-09
Granted: 1985-02-13
Abstract: The invention relates to an improved protective solution for preventing ischemia damage to the heart and kidneys, and other organs during operations and transplantations, characterized by the fact that it contains  alpha -ketoglutarate and a buffer system based on histidine/histidine hydrochloride and tryptophane, as well as the usual electrolytes for cardioplegic solutions. The invention also relates to a process for the preparation of such a protective solution.
Patent EP-0045187-B1 (EP)
IPC: C12P/
Filed: 1981-07-23
Granted: 1984-10-10
Abstract: A process for enzymatic replacement of the B-30 amino acid in insulins, in which the insulin Ins-X, wherein Ins represents the insulin molecule except for X which represents the B-30 amino acid, is reacted with an amine component selected from amino acids, and their amides and esters, of the formulae
 H-B-OH
 H-B-NR<1>R<2>
 H-O-OR<3>
 H-B-SR<3>
 H-B-SeR<3>
 wherein B is an amino acid residue; either R<1> and R<2> are independently selected from hydrogen, amino, hydroxy, alkyl, cycloalkyl, aryl, heteroaryl and aralkyl or NR<1>R<2> is a heterocyclic group which may contain a further hetero atom; and R<3> is alkyl, cycloalkyl, aryl, heteroaryl or aralkyl; in the presence of an L-specific serine or thiol carboxy-peptidase enzyme, in an aqueous solution or dispersion having a pH from about 7 to 10.5, to form an insulin derivative of the formulae
 Ins-B-OH, Ins-B-NR<1>R<2>, Ins-B-B-NR<1>R<2>
 Ins-B-OR<3>, Ins-B-SR<3> or Ins-B-SeR<3>
 wherein Ins, B, R<1>, R<2> and R<3> are as defined above; and, if desired, cleaving any -NR<1>R<2>, -B-NR<1>R<2>, -OR<3>, -SR<3> or -SeR<3> group. The invention allows human insulin to be prepared from porcine insulin and threonine.
Patent EP-0065734-B1 (EP)
IPC: A47G1/04
Filed: 1982-05-17
Granted: 1985-09-18
Abstract: PCT No. PCT/EP82/00107 Sec. 371 Date Jan. 18, 1983 Sec. 102(e) Date Jan. 18, 1983 PCT Filed May 19, 1982 PCT Pub. No. WO82/03982 PCT Pub. Date Nov. 25, 1982.An overhead viewing mirror apparatus for bedridden and paralyzed persons, comprising a vertically adjustable mount to which mirrors are attached, wherein a center mirror is provided which has a mirror surface on either side thereof and which is adapted to be pivoted from a vertical starting position over an angle of up to 30 DEG  to either side about an axis or shaft; one lateral mirror is each mounted on both sides of the center mirror in a position angularly inclined relative to the latter; and the whole mirror assembly is rotatable about a vertical axis or shaft.
Patent EP-0068160-B1 (EP)
IPC: A61K31/13
Filed: 1982-05-29
Granted: 1986-10-29
Abstract: 1-(p-2-iso-propoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol and its biocompatible salts are very useful in decreasing the intra-ocular pressure, e.g., to treat glaucoma.
Patent EP-0075765-B1 (EP)
IPC: C08K3/40
Filed: 1982-09-10
Granted: 1986-02-26
Abstract: The addition of an unsaturated fatty acid ester to low shrinking polyester molding compositions containing unsaturated polyesters results in moldings with improved surface characteristics.
Patent EP-0066420-B1 (EP)
IPC: B41L1/20
Filed: 1982-05-20
Granted: 1985-07-31
Abstract: The invention is concerned with a business forms assembly of the kind sometimes referred to as a "snap-out' set which may be of self manifolding paper (sometimes called self copy paper) or of record sheets (1) interleaved with transfer sheets (carbon paper sheets). The assembly comprises a plurality of interleaved sheets (1) secured together at or adjacent one edge by adhesive (2) to form a stub and with transfer material between the sheets and wherein an extension sheet part (5) extends beyond the secured stub edge to provide a means for feeding the interleaved sheets (1) into a print unit (11 to 15).
Patent EP-0084259-B1 (EP)
IPC: G11C27/02
Filed: 1982-12-23
Granted: 1991-03-13
Abstract: A sample and hold circuit is disclosed, in which first and second terminals to which are supplied drive currents for turning ON and OFF a diode bridge are respectively connected through capacitors to a connection point between output electrodes of switching elements, a diode is connected between the first and second terminals for short- circuiting the capacitors when the diode bridge is made OFF, and input electrodes of the switching elements are respectively connected to first and second points of a reference potential whereby said diode bridge is made ON by a drive current flowing from the first point to the second point of the reference potential.
Patent EP-0085057-B1 (EP)
IPC: B26F1/46
Filed: 1982-06-14
Granted: 1985-09-18
Abstract: A punching apparatus for punching items having curved or arched edges from sheet material, particularly labels and similar printed matter items, comprises a punching die in the form of a mainly tubular member (6) manufactured from a sintered carbide alloy and having an internal cavity in which at least the wall surfaces (8) at the cutting edge are ground to smoothness, preferably to a surface roughness Ra < 0.1  mu m, and are perpendicular to the plane of the cutting edge, whereas grinding of the cutting edge 97) into a prescribed sharpness and cutting angle is performed solely on the external side of the tubular member (6). As a result thereof the intervals between necessary re-grindings of the cutting edge (7) are prolonged and an unlimited number of re-grindings may be made in practice with full retention of the accuracy of measurement of the cutting edge.
Patent EP-0112571-B1 (EP)
IPC: C12N9/80
Filed: 1983-12-23
Granted: 1987-08-05
Abstract: The present invention provides a process for the determination of N-carbamoylsarcosine, wherein a sample solution containing N-carbamoylsarcosine is reacted with N-carbamoylsarcosine-amidohydrolase to give sarcosine, which is then determined. The present invention also provides the enzyme N-carbamoylsarcosine-amidohydrolase, a process for obtaining it and a reagent containing it.
Patent EP-0112895-B1 (EP)
IPC: H03K5/153
Filed: 1983-06-08
Granted: 1988-02-03
Abstract: Un circuit de détection de tension (10) possède un transistor à effet de champ du type P (12) couplé en série avec un transistor à effet de champ du type N (14) entre un premier noeud de tension d'alimentation (16) et un noeud d'entrée (22), ses portes étant couplées à un second noeud de tension d'alimentation (20). Si la résistance du transistor à effet de champ (14) est sensiblement supérieure à celle du transistor à effet de champ (12), le noeud de sortie (18) aura sensiblement la première tension d'alimentation lorsque le signal d'entrée est absent, et il aura la tension du signal d'entrée lorsque ce dernier est présent. Un circuit de transformation de tension (40) possède un transistor à effet de champ du type P (42) couplé en série avec un transistor à effet de champ du type N (44) ayant un premier noeud de tension d'alimentation (50) et un noeud d'entrée (56), leurs portes étant couplées à un autre noeud d'entrée (54). Un transistor à effet de champ du type N (46) est interposé entre le transistor à effet de champ (42) et le transistor à effet de champ (44) et sa porte est couplée à un autre noeud d'entrée (58). Un autre transistor à effet de champ du type N (48) est connecté en parallèle aux transistors à effet de champ (44, 46) entre le noeud de sortie (52) et le noeud d'entrée (56) et sa porte est couplée à un second noeud de tension d'alimentation (60).