Patent SG-11201901444P-A (SG)
Title: Highly concentrated low viscosity masp-2 inhibitory antibody formulations, kits, and methods
Inventor: DEMOPULOS GREGORY
IPC: A61K47/00
Filed: 2017-08-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) W I PO I iiiiono 1E1 oio llmonoloolo Elio° !moo im iflo °El (10) International Publication Number WO 2018/045054 Al PCT Av erag e Loa d ( lbf) 6 5 4 3 2 1 O 00 0 (51) International Patent Classification: A61K 9/08 (2006.01) A61K 47/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2017/049415 (22) International Filing Date: 30 August 2017 (30.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/382,156 31 August 2016 (31.08.2016) US (71) Applicant: OMEROS CORPORATION [US/US]; 201 Elliott Avenue West, Seattle, WA 98119 (US). (72) Inventors; and (71) Applicants: DEMOPULOS, Gregory, A. [US/US]; 4845 Forest Avenue Se, Mercer Island, WA 98040 (US). FER- GUSON, Kenneth, M. [US/US]; 2125 First Avenue #2902, Seattle, WA 98121 (US). LAMBERT, William, Joseph [US/US]; 88 Virginia St. #23, Seattle, WA 98101 (US). WHITAKER, John, Steven [US/US]; 1510 40th Avenue, Seattle, WA 98122 (US). (74) Agent: QUINTON, Tineka; Omeros Corporation, 201 El- liott Avenue West, Seattle, WA 98119 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: HIGHLY CONCENTRATED LOW VISCOSITY MASP-2 INHIBITORY ANTIBODY FORMULATIONS, KITS, AND METHODS Syringeability: Average Load 1 1 1 1 1 27 GA I 25 GA I 25 GA (Thin-Wall) 185 mg/mL 20 mM Citrate, 200 mM Arginine 0.01% PS-80, pH 5.8 27 GA I 25 GA I 25 GA (Thin-Wall) 185 mg/mL 20 mM Histidine, 200 mM Arginine 0.01% PS-80, pH 5.9 27 GA I 25 GA I 25 GA (Thin-Wall) 185 mg/mL 20 niM Citrate, 200 mM Arginine pH 5.8 FIG. 7A (57) : The present invention relates to stable, high-concentration low-viscosity formulations of MASP-2 inhibitory antibodies, kits comprising the formulations and therapeutic methods using the formulations and kits for inhibiting the adverse effects of MASP-2 C dependent complement activation. [Continued on next page] WO 2018/045054 Al MIDEDIMOMOIDEIREEMOMIVINIMEHIMEMOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))