baber/WOPTO huggingface dataset:
Patent PT-1002110-E (PT)
Inventor: MIZZEN LEE
IPC: A61K39/00
Filed: 1998-03-20
Abstract: This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein -HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.
Patent PT-991510-E (PT)
Inventor: ROBICHON PATRICE
IPC: C08L97/00
Filed: 1998-06-25
Abstract: The invention relates to a process for manufacturing a composition which can be used for producing stoppers. According to the invention, it comprises the following steps: a) sheets of cork are ground into small-sized granules, b) said cork granules are decomposed into granules having a high lignin content and into granules having a high suberin content, and c) the lignin-rich granules are separated from the suberin-rich granules in order to keep only the suberin-rich granules in said composition. The invention also relates to a composition comprising suberin-rich cork granules as well as to a stopper comprising such a composition.
Patent PT-1032560-E (PT)
Inventor: FEUERSTEIN THOMAS J
IPC: C07D209/54
Filed: 1998-11-17
Abstract: Use of 4-substituted 2-pyrrolidinone derivatives (I) as drugs, specifically for reducing extracellular glutamate levels, is new. Use of 2-pyrrolidinone derivatives of formula (I) and their salts and prodrugs as therapeutic active agents is new. [Image] R1, R2H, OH, NH2, 1-10C alkoxy, 1-10C alkyl or 1-10C alkylamino, but not both H; or CR1R25-10 membered saturated or unsaturated ring, optionally containing 1 or 2 O, S or N heteroatom(s) and optionally substituted by 1-3 of OH, NH2, 1-4C alkyl, 1-4C alkoxy and 1-4C alkylamino; R3-R6H, OH, NH2, 1-10C alkyl, 1-10C alkoxy, 1-10C alkylamino or 6-10C aryl; R7H, 1-10C alkyl or 1-10C acyl. An independent claim is also included for the use of (I) or their salts for the treatment and/or prophylaxis of diseases associated with elevated extracellular glutamate levels. ACTIVITY : Neuroprotective; glutamate neurotoxicity inhibitor. In a glaucoma model of neurodegeneration in rats, 8-aza-spiro (5,4) decan-9-one (Ia) was administered at 50 mg/kg i.p. before and after increase of intraocular pressure. The average degree of survival of retinal ganglion cells 14 days later was 35.0%, compared with 17.4% for saline-treated controls. No deaths were observed in the (Ia)-treated group in 14 days. MECHANISM OF ACTION : Glutamatergic neurotransmission inhibitor. (I) reduce extracellular glutamate levels and inhibit the depolarisation and over-stimulation of post-synaptic cells, e.g. by presynaptically released glutamate.
Patent PT-1103564-E (PT)
Title: Cancer antigens based on tumor suppressor gene wt1 product
Inventor: SUGIYAMA HARUO
IPC: A61K39/00
Filed: 1999-07-30
Abstract: The present invention relates to a nucleic acid encoding WT1 or a portion thereof for use as a vaccine.
Patent SG-35292-G (SG)
Title: Positive photoresist systems
IPC: G03F7/004
Filed: 1992-03-24
Abstract: This invention concerns a positive photoresist comprising a preformed, non-crosslinked polglutarimide dissolved in a non-aqueous, spinning solvent. The positive photoresist may be used to achieve high resolution images by exposure to a wide range of wavelengths and development using an aqueous base developer. The photoresist is also suitable for use as a planarizing layer in a multiple layer system.
Patent SG-87690-G (SG)
Title: Electric motor
IPC: H02K7/20
Filed: 1990-10-25
Abstract: A flat electronically commutated motor is described whose rotor has been provided with an axially magnetized annular magnet (26) which cooperates with axially facing bounding surfaces (2-7) of the stator poles outside the stator coil ends, which enables the axial dimension of the stator iron (1) to be reduced without reducing the effective surface area of the stator teeth. This construction enables Hall elements (44-46) to be mounted on a p.c. board (28) which Hall elements (44-46) are arranged in the main field of the rotor magnet (26).
Patent IE-32122-L (IE)
Title: Physical training appararus.
IPC: A63B23/035
Filed: 1968-02-14
Abstract: 1,210,423. Physical training apparatus. A. R. MACABET and J.-D. MACABET. 2 Feb., 1968 [16 Feb., 1967; 5 Jan., 1968], No. 5494/ 68. Heading A6M. A portable P.T. apparatus shown in Fig. 1 has, in combination, a pulley 4 and a means of fastening at 17 to a fixed point, a main cable 5 passing over this pulley 4, two secondary pulleys 6 and 6a fixed at the free ends of this main cable 5 and two secondary cables 7 and 8 each passing over one of the secondary pulleys and respectively equipped with means of holding 10 and 13 suited for the upper and lower limbs. The pulleys are preferably equipped with swivels and snap hooks (Fig. 5-not shown). The modes of holding the apparatus are illustrated in Figs. 2, 3 and 4 (-not shown) and may be varied by the use of a head strap or mouthpiece. The apparatus may be varied by using pattens to simulate snow or water skiing where the pattens are constructed on a frame which keeps them parallel but allows forward and backward motion. The pattens may have a central ridge at the lowest point with facets which form a) at constant external salient angle of about 220‹ or b) develop on each' side of the central ridge a helicoidal shape such that the external salient angle at the rear of the patten decreases progressively towards the front until it forms a re-entrant angle at the front.
[GB1210423A]
Patent IE-880717-L (IE)
Title: Human manganese superoxide dismutase (hMn-sod)
IPC: C12N15/62
Filed: 1988-03-11
Abstract: A genetic engineering method for the production of human Mn superoxide dismutase (hMn-SOD), the DNA sequences which code for this enzyme, suitable vectors which contains these DNA sequences and host cells which can express these DNA sequences, as well as the enzyme hMn-SOD itself are described. Proposals for the use of this enzyme are additionally described.
Patent IE-37716-L (IE)
Title: Analytical determination.
IPC: G01N31/22
Filed: 1973-05-28
Abstract: Process for the determination of a component of a reaction system, which determination is based upon the oxidation of a chromogenic compound and in which determination use is made of a test paper containing the remaining components of the reaction system. Such determinations are often disturbed by undesired compounds being present in the test fluid containing the component to be determined. The process is characterized in that the test fluid is first contacted with a material consisting essentially of cellulose or a cellulose-like substance, which material has been subjected to a treatment with an oxidizing agent.
[US3868219A]
Patent IE-860862-L (IE)
Title: Wire drawing die
IPC: C04B35/52
Filed: 1986-04-02
Abstract: A wire drawing die is provided which is characterised by containing a particular thermally stable diamond compact through which a hole is formed for receiving the wire to be drawn therethrough. The thermally stable diamond compact, which preferably has a hexagonal or circular shape in plan, comprises a mass of diamond particles present in an amount of 80 to 90 percent by volume of the compact and a second phase present in an amount of 10 to 20 percent by volume of the compact, the mass of diamond particles containing substantial diamond-to-diamond bonding to form a coherent, skeletal mass and a second phase consisting essentially of silicon, the silicon being in the form of silicon and/or silicon carbide.
Patent IE-850984-L (IE)
Title: Oral hygiene compositions
IPC: A61K8/20
Filed: 1985-04-17
Abstract: An oral hygiene composition containing an effective concentration of a pharmaceutically acceptable fluoride salt, a pharmaceutically acceptable zinc salt, a specific buffering agent a suitable vehicle and having a pH of from about 3.5 to 6.0.
Patent FI-852683-L (FI)
Inventor: DEFREITAS ELAINE
IPC: C12R1/91
Filed: 1985-07-05
Abstract: Anti-idiotype antibodies, their production and their use in inducing an immunological response to viruses.
Patent FI-853822-L (FI)
Inventor: PUFF ROGER MARCEL
IPC: F23L9/06
Filed: 1985-10-02
Abstract: A fluidized-bed apparatus with a heat exchanger and an additional-air blowing network. The heat exchanger comprises upright tubes extending from a lower header which is slightly inclined to the horizontal, to an upper header. The lower header consists of an internal duct which is connected to the tubes and an external duct which has blowing nozzles and is connected to an additional-air supply line in order to alter the height of the bed in which the upright tubes are immersed.
Patent IE-34534-L (IE)
Title: Bending glass sheets
IPC: C03B23/03
Filed: 1970-09-17
Abstract: A method and apparatus for bending glass sheets in which a sheet is heated, prebent convexly upward by applying a jet of cool air to the upper surface thereof, and then bent in the opposite direction on an inertia-gravity bending mold. The apparatus includes an air nozzle which is arranged and controlled such that cooling air is applied only to the central area of the sheet in order to prevent edge vents from occurring.
[US3632326A]
Patent IE-841254-L (IE)
Title: SUBSTITUTED 1,2,3 - TRIAZINO £4',5':4,5| THIENO £2,3-b|¹QUINOLIN -4(3H)- ONES
IPC: C07D495/22
Filed: 1984-05-21
Abstract: Substituted 1,2,3-triazino[4',5':4,5]thieno[2,3-b]quinolin-4(3H)-ones useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate substituted 3-aminothieno-[2, 3-b]quinotine-2-carboxamide with sodium nitrite in an acid such as acetic acid.
Patent IE-841369-L (IE)
Title: Fabric softening composition for use in admixture with¹particulate detergent composition
IPC: C11D1/62
Filed: 1984-05-31
Abstract: A fabric softening composition is provided for use in admixture with a particulate detergent composition or as a softening additive to the wash solution separate from the detergent composition, such softening composition comprising: (i) discrete softening particles containing at least about 75%, by weight, of a smectite-type clay, and less than about 5%, by weight, of detergent surface active agents selected from the group consisting of anionic, nonionic, ampholytic and zwitterionic detergents; and (ii) a cationic compound selected from the group consisting of primary, secondary and tertiary amines and their water-soluble salts, diamine and diammonium salts, and quaternary ammonium, phosphonium and sulfonium compounds, substantially all of said cationic compound being adsorbed upon the surface of said particles.
[US4536316A]
Patent IE-32498-L (IE)
Title: Pharmceutical preparation
IPC: A61K31/47
Filed: 1968-11-20
Abstract: 1,200,999. Pharmaceutical and veterinary preparations. CIBA Ltd. 25 Nov., 1968 [24 Dec., 1967], No. 55743/68. Heading A5B. Pharmaceutical and veterinary preparations having antibacterial and antiparasitic activity for the treatment and/or prophylaxis of intestinal troubles comprise (1) 4,7-phenathroline-5,6- quinone and (2) 5,7-dichloro-8-hydroxy-quinoline in admixture or conjunction with a pharmaceutically suitable carrier. The preparations may be administered orally in the form of capsules, tablets, syrups, suspensions or dragees which may be enterically coated with cellulose acetate-phthalate and diethylphthalate. The preparations may also contain (3) a spasmolytic e.g. diethyl-(2-hydroxyethyl)-methyl-ammonium bromide-α-phenyl-cyclohexane-glycolate.
[GB1200999A]
Patent IE-841595-L (IE)
Title: Detection of photoelectric means of markings made on a¹travelling material web
IPC: G06K7/14
Filed: 1984-06-22
Abstract: A method and an arrangement is disclosed for the detection by photoelectric means of markings made on a printed, decorated material web. The markings comprise two groups of stroke markings, the markings of a first group being arranged to be sensed by a first photocell element, which, on sensing the first group markings causes the output of a second photocell element, which senses the stroke markings of a second group of making to be fed into a memory unit for continuous comparison with a stored value. In response to the comparison, a control signal is generated to control the performance of various operations on the web.
[SE8303845D0]
Patent IE-45331-L (IE)
Title: Mooring apparatus.
IPC: B63B27/30
Filed: 1977-08-10
Abstract: A hydraulic reactor system for minimizing mooring forces of a vessel attached to an offshore structure, by means of a ramp which enables access between the two, comprising a structural frame provided with a hydraulic piston utilizing a one-way pressure relief valve which allows inward movement with minimal resistance. Conversely, the outward movement of the hydraulic piston provides considerable resistance. The device is connected to, or involved in, a ramp structure allowing an extension or reduction in length of the radius of the geometric configuration as it pivots vertically when attached to a vessel on its outboard end. The upward movement energizes the system by compressive action with minimal resistance, while the downward movement produces considerable resistance to outboard movement of the vessel. This vertical movement of the vessel caused by the waves produces reaction forces in a direction against those elements such as wind, waves and current that would tend to cause horizontal movement of the vessel. It is this process of gently nudging the boat in an up weather direction, with each of its downward movements, the causes an interial reaction that overcomes the forces of the environment with minimal effort. The device can be pivotally attached to a mooring point, known as a "king post", allowing the device and attached ramp/vessel to "weathervane" about the "king post" responsive to changes in direction of the mooring forces.
[CA1065692A]
Patent IE-871765-L (IE)
Title: Acyl derivatives
IPC: C07D501/34
Filed: 1987-07-02
Abstract: Cephalosporin derivatives of the formula <IMAGE> in which m represents 0, 1 or 2, R<1> represents hydrogen or an acyl group, R<2> represents hydrogen, lower alkoxy, amino, lower alkylthio or lower alkanoylamino, R<3><1> represents hydrogen, lower alkyl, lower alkenyl, C3-C7-cycloalkyl, halogen-lower alkyl or halophenyl; Z represents R<3><0>-C or nitrogen, R<3><0> represents hydrogen or halogen, or R<3><0> and R<3><1> together represent a C3-C5-alkylene group, a C2-C4-alkylene- monooxy group or a C1-C2-alkylenedioxy group, R<3><2> represents hydrogen, halogen, lower alkyl or an optionally substituted 5- or 6-membered heterocyclic ring having one, two or three oxygen, nitrogen and/or sulphur atoms and R<3><3> represents hydrogen or halogen or R<3><2> and R<3><3> together represent a C1-C4-alkylenedioxy group, and easily hydrolysable esters and salts of these compounds and hydrates of the compounds of the formula I or of their esters and salts are described. The products have antimicrobial activity.
Patent IE-801824-L (IE)
Title: Positive-working resist materials
IPC: H01L21/027
Filed: 1980-08-29
Abstract: An improved positive-working resist material capable of forming on a substrate either a positive resist pattern or a negative resist pattern. The positive-working resist material comprises a positive-working resist resin having incorporated therein one or more photochromic compounds, such as spiropyrans, triphenylmethane dyes, anils and the like. A positive or negative resist pattern having a remarkably improved definition can be obtained. The use of such a positive-working resist material in the formation of a negative resist pattern on the substrate is also disclosed.
[US4444869A]
Patent IE-852054-L (IE)
Title: Calcium up-take inhibitors.
IPC: A61P9/00
Filed: 1985-08-21
Abstract: Compounds are described of the formula <IMAGE> (I) wherein R1 and R4 independently represent a C1-4 alkyl group; R2 and R3 independently represent a C1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom; R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by a C1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion cencentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.
[US4801599A]
Patent IE-822108-L (IE)
Title: Metal complexes
IPC: A61K9/18
Filed: 1982-08-31
Abstract: PCT No. PCT/EP82/00184 Sec. 371 Date Apr. 29, 1983 Sec. 102(e) Date Apr. 29, 1983 PCT Filed Aug. 28, 1982 PCT Pub. No. WO83/00868 PCT Pub. Date Mar. 17, 1983.Metal complexes of the general formula I [R1(CH2)mC(O)CR3C(O)R2]2M(OR4)2-nXn (I) wherein M denotes titanium, zirconium or hafnium, R1 denotes hydrogen, C1-C8-alkyl or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C1-C4-alkyl, C1-C4-alkoxy or trifluoromethyl, R2 denotes C1-C8-alkyl, or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C1-C4-alkyl, C1-C4-alkoxy or trifluoromethyl, R3 denotes hydrogen or phenyl, R4 denotes C1-C18-alkyl, which can be substituted by hydroxyl, C1-C3-alkylamino or alkali metal sulfonato groups, or denotes C5-C8-cycloalkyl, which can be substituted by C1-C5-alkyl groups, hydroxyl or alkali metal sulfonato groups, X denotes fluorine, chlorine or bromine, m denotes the number 0 or 1, but does not denote 0 if R1 denotes hydrogen, and n denotes the number 0 or 1, and, if a radical R4 contains an amino group, hydrohalides thereof, exhibit a very good cytostatic activity, coupled with low toxicity. They are suitable for the production of medicaments having an antineoplastic action.
Patent IE-882170-L (IE)
Title: Subsituted n-(3-hydroxy-4-piperidinyl) benzamides
IPC: A61K31/47
Filed: 1988-07-15
Abstract: Novel N-(3-hydroxy-4-piperidinyl)substituted benzamides of formula   <CHEM>  wherein: R<1> is hydrogen, C1-6alkyl, arylC1-6alkyl, C1-6alkylcarbonyl, aminoC1-6alkyl or mono- and di(C1-6alkyl)aminoC1-6alkyl;  R<2> is hydrogen or C1-6alkyl; R<3>, R<4> and R<5> each independently are hydrogen, C1-6alkyl, C1-6alkyloxy, halo, hydroxy, cyano, nitro, amino, mono- and di(C1-6alkyl)amino, aminocarbonyl, arylcarbonylamino, C1-6alkylcarbonylamino, C1-6alkylcarbonyl, C1-6alkylcarbonyloxy, aminosulfonyl, C1-6alkylaminosulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkylthio, mercapto, trifluoromethyl, arylC1-6alkyloxy or aryloxy;  Alk is a C1-6alkanediy;  X is O, S, NR<6> C(=O) or C(=S); Het is a five- or six membered heterocyclic ring being optionally fused with a six membered carbocyclic ring, and being optionally substituted; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are gastrointestinal motility stimulating agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
Patent IE-41945-L (IE)
Title: Distributor apparatus.
IPC: B28B13/02
Filed: 1975-11-21
Abstract: An apparatus for distributing aqueous calcium sulphate alpha -hemihydrate suspension over various casting moulds of casting machines which are adapted to the manufacture of gypsum (plaster of Paris) mouldings consists of a collecting device (4) for receiving the calcium sulphate alpha -hemihydrate suspension, a movable line (5) which is connected to the flow of the collecting device (4), several chutes (6) which lead to various casting machines, a funnel (11) for collecting excess material, the chutes (6) protruding into the upper region of the funnel, and a discharge line (12) through which liquids containing calcium sulphate alpha -hemihydrate and running out of the funnel can be recycled to the plaster of Paris preparation equipment. A lifting device (7) is located above the movable line (5) and is frictionally connected with the end of the movable line which faces away from the collecting device. The movable line (5) is furthermore connected to a rotatably mounted pivoting device (8), by means of which the movable line (5) can be moved in a horizontal direction. <IMAGE>
[GB1477459A]
Patent IE-44433-L (IE)
Title: Derivatives of thienamycin and its isomers
IPC: C07D498/04
Filed: 1976-11-18
Abstract: Amidines of the general formula (II) <IMAGE> in which the substituents are defined in Claim 1, and their pharmaceutically acceptable salts, are obtained by treating thienamycin (I), while temporarily protecting the oxygen functions and/or the carboxyl function, with an imidoester or with an imidohalide, and, where appropriate, converting the resulting compounds into their pharmaceutically acceptable salts. The novel compounds, which can be prepared in accordance with the invention, are novel, valuable antibiotics which, as a rule, are active against various Gram-positive and Gram-negative bacteria, and may, therefore, be used in human and veterinary medicine.
[GB1570990A]
Patent IE-882971-L (IE)
Title: Oligonucleotide functionalising reagents
IPC: C12Q1/6816
Filed: 1988-09-30
Abstract: Oligonucleotide functionalizing reagents are disclosed which are useful in introducing sulfhydryl, amino and additional hydroxyl groups into oligonucleotides. The reagents are substantially linear in structure, at one end provided with a phosphoramidite moiety, at an opposing end provided with a sulfhydryl, amino or hydroxyl moiety, the two ends linked through a hydrophilic spacer chain. Methods of using and synthesizing the novel reagents are disclosed as well.
[US4914210A]
Patent IE-940633-L (IE)
Title: Blunt-ended cannula device
IPC: A61M25/00
Filed: 1990-03-15
Abstract: A pre-slit injection site (34) includes a housing (40) with a flow path therethrough. A first end (42) of the housing (40) carries a pre-slit septum (52). One form of a blunt cannula (98), usable with the injection site (34), carries a locking member (100). When the pre-slit injection site (34) slidably receives the blunt cannula (98), the locking member (100) latches to the injection site (34) and creates a mechanically coupled unit. Another form of the cannula (280) includes a tube having a tapered distal end region (298) and having elongate discharge slots (294) for reducing contact surface area and for directing the flow laterally out of the cannula. The cannula may also include a rounded lead post (330), an annular barb (394), and axially oriented grooves (268).
[US2001047154A1]
Patent NO-753231-L (NO)
Title: Innleggsstykke for madrass.
Inventor: HARGEST THOMAS SEWELL
IPC: A47C/
Filed: 1975-09-23
Abstract: Innleggsstykke for madrass.