Patent SG-11201807811R-A (SG)
Title: Food compositions for weaning
Inventor: KYLE DAVID
IPC: A61K31/702
Filed: 2017-03-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 0111011111011011100 111111 10 EDO IIE III 11 International Bureau ... .1 j ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/156548 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: A61K 35/74 (2015.01) A61K 31/00 (2006.01) (21) International Application (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/307,425 11 March (71) Applicant: EVOLVE BIOSYSTEMS 2121 2nd Street, Suite B107, (72) Inventors: KYLE, David; 95445 (US). FREEMAN-SHARKEY, Hamel Street, Davis, CA 95618 9163 Olmos Lane, Davis, CA (81) Designated States (unless otherwise indicated, for every A61K 31/702 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/022207 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 13 March 2017 (13.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 2016 (11.03.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, INC. [US/US]; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Davis, CA 95618 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, P.O. Box 119, Gualala, CA TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Samara; 5248 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (US). FRESE, Steven; LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 95616 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). W. et al.; Hunton and Willi- Published: Avenue, NW, Washington, — with international search report (Art. 21(3)) Agents: PEARLMAN, Anne, (74) ams LLP, 2200 Pennsylvania DC 20036 (US). = (54) Title: FOOD COMPOSITIONS FOR WEANING 7007 Iffi Other ::ff Iff ,ysipelotrichaceee Enterococcaceae Vaillonellaceae ff Staphylococcaceae , achnospiraceae \" , ostriCiaceae l'reptococcaceae Bacteroidaceae ff Enterobacteriaceae 410511111111 — 1.0. — '''' . ...... - III Bifidobacteriaceae 0 .'` '\" r, 4 , i c o 1ff 0§ 4 , g' Day of Life FIG. 3A herein relate generally to digestive healthcare, and more particularly, to the feeding of who are making a transition from a inicrobiome with lower diversity to a microbiome with relate to certain foods comprising a fermentable nutritional component and a probiotic compon - is selected, based on genetic and/or metabolic criteria, to specifically metabolize any Free Sugar Acids (FAAs) or peptides that accumulate as a result of the fermentable nutritional component - GC 71' kin (57) : The inventions described il f ) mammals, particularly human infants, 1-1 ---- higher diversity. These inventions IN ent, where the probiotic component C Monomers (FSMs) and Free Amino N in the lower intestine, where they otherwise might be left in the environment to be fermented and metabolized by less adapted/oppor - 0 tunistic bacteria, creating blooms of deleterious intestinal bacteria and shifting the microbiome to a potentially dysbiotic state. The ,..1: present inventions provide combinations of foods and probiotic bacteria that can protect the mammalian gut from blooms of patho - .,- genic bacteria.