Patent SG-11201804184S-A (SG)
Title: New 5-azido-5-deoxy-2 :3-isopropylidene-d-arabinose compounds; their method of manufacture and their use for the synthesis of ara-n3, kdo-n3 and 4ekdo-n3
Inventor: VAUZEILLES BORIS
IPC: C07H13/00
Filed: 2016-11-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau (43) International Publication Date .... ..... .r ...) 26 May 2017(26.05.2017) WIPO I PCT II (10) 11111111111111111111 WO International 111111111111 2017/085144 IIIIIIIIIIIIIH Publication Al Number IIIIIIIIIIIIIIRIIIIIIIIIIIIIII (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07H 1/00 (2006.01) CO7H 9/04 (2006.01) kind of national protection available): AE, AG, AL, AM, C07H 5/04 (2006.01) CO7H 13/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07H 7/027 (2006.01) C07D 317/30 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/EP2016/077900 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (22) International Filing Date: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 16 November 2016 (16.11.2016) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (25) Filing Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (26) Publication Language: English ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 15306824.2 17 November 2015 (17.11.2015) EP kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CENTRE NATIONAL DE LA RECHER- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, CHE SCIENTIFIQUE [FR/FR]; 3, rue Michel Ange, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 75016 Paris (FR). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: VAUZEILLES, Boris; 10, avenue du Presid- ent Franklin Roosevelt, 92330 Sceaux (FR). MAS PONS, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Jordi; C/ Cal Princep 39, 08191 Rubi (ES). BARON, GW, KM, ML, MR, NE, SN, TD, TG). Aurelie; Auteuil 3, Bois de Boulogne, 95290 L'Isle Adam Published: (FR). 21(3)) — with international search report (Art (74) Agents: PORTAL, Gerard et al.; Cabinet BEAU DE LO- MENIE, 158, rue de l'Universite, 75340 Paris Cedex 07 (FR). Title: NEW 5-AZIDO-5-DEOXY-2 COMPOUNDS; THEIR METHOD OF MANU- (54) :3-ISOPROPYLIDENE-D-ARABINOSE FACTURE AND THEIR USE FOR THE SYNTHESIS OF ARA-N3, KDO-N3 AND 4EKDO-N3 R 1 0 R 2 o o 2 1-1 OH 1 .4t i t it Formula V, X=NOR 3 ; Formula 1-1 % '%- s : x VI, X=O un ce o IN (57) : The invention relates to new compounds of formulae: Wherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl 1-1 o including methyl, ethyl, propyl, butyl; awl including phenyl, para-methoxyphenyl; or R 1 , R 2 together with the carbon C-6 can be a ei cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including 0methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tent-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these 6t groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3, Kdo-N 3 and 4eKdo-N 3.