baber/WOPTO huggingface dataset:
Patent CR-20230158-A (CR)
Title: Tetrahydroisoquinoline derivatives for the treatment of red blood disorders and inflammatory diseases
Inventor: KARAGEORGE GEORGE
IPC: C07D471/18
Filed: 2021-09-14
Abstract: Provided herein are compounds and compositions thereof for activating nuclear factor erythroid 2-related factor 2 (Nrf2) for treating red blood cell diseases and inflammatory diseases.
Patent CR-20230165-A (CR)
Title: Indole derivatives as ras inhibitors in the treatment of cancer
Inventor: AAY NAING
IPC: A61K31/5025
Filed: 2021-09-15
Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Patent EC-SP045474-A (EC)
Title: 1-(aminoalquil)-3-sulfonilazaindoles como ligandos de 5-hidroxitriptamina-6
IPC: A61P25/14
Filed: 2004-12-02
Abstract: La presente invención proporciona un compuesto de fórmula (I) y el uso del mismo para el tratamiento terapéutico de desórdenes en relación o que afectan al receptor 5-HT6.
Patent EC-SP077164-A (EC)
Inventor: HERDER MARTIN
IPC: A61M15/00
Filed: 2007-01-12
Abstract: In order to improve the security and reliability of administration of powdered pharmaceuticals through dry powder inhalers, the invention proposes an inhaler (1) for powdered medicaments, comprising an activating device (4) for manual engagement by the patient for repeatedly metering a dose of medicament to be administered to the patient, and further comprising an advancing mechanism (25) for advancing a counter or indexing means (8) each time the activating device (4) has been engaged by the patient so that a dose of medicament has been released for administration to the patient, wherein the counter or indexing means (8) comprises an index (9), the index (9) being detectable by a detection means (10) of the inhaler, and the detection means (10) being coupled to a locking mechanism (12), the locking mechanism (12) blocking the activating device (4) and/or any transportation mechanism (5) of the inhaler (1) delayed by a predetermined number of metering cycles since detection of the index (9), and a cartridge (3).
Patent EC-SP088273-A (EC)
Title: Sistema de frenos para un elevador de perforación o servicio de pozo
IPC: B01F23/47
Filed: 2008-03-13
Abstract: El sistema de frenos incluye una palanca de freno independiente de, pero capaz de rotar cerca del mismo punto como una palanca angular. Hasta recibir una fuerza hacia abajo, un miembro extendiéndose desde la palanca golpea una porción de la palanca angular y genera una fuerza que causa que la palanca angular rote. La acción rotacional de la palanca angular transfiere la energía rotacional a una barra ecualizadora a través de un sistema de articulación. La rotación de la barra ecualizadora incrementa o disminuye la tensión sobre las bandas de freno que retardan un tambor de tubo. Un cilindro puede activar y causar que la barra ecualizadora rote, aplicando la tensión a las bandas de freno y retardando el tambor. La energía rotacional es transferida detrás de la palanca angular a través de la articulación. La energía rotacional es absorbida por un resorte posicionado entre la palanca angular y la palanca de freno, por lo cual, reducir la cantidad de fuerza súbita pasada a través de la palanca de freno a un operador.
Patent EC-SP099580-A (EC)
Title: Sales 668
Inventor: WHITTOCK ROBERT
IPC: A61K31/428
Filed: 2009-08-14
Abstract: Una sal farmacéuticamente aceptable de N-[2-(dietilamino)etil]-N-(2-{[2-(4-hidroxi-2-oxo-2,3-dihidro-1,3-benzotiazol-7-il)etil]amino}etil)-3-[2-(1-naftil)etoxi]propanamida siempre que no sea la sal dibromhidrato o diclorhidrato; y el uso de tal compuesto como un medicamento (por ejemplo, en el tratamiento de enfermedades respiratorias (tales como asma EPOC)).
Patent EC-SP109971-A (EC)
Title: Una bebida y metodo para su preparación
Inventor: KOPONEN LEENA
IPC: A23L33/00
Filed: 2010-02-18
Abstract: La invención se refiere a una bebida estable que comprende al menos un componente de textura seleccionado del grupo que consiste de puré de vegetales no homogenizado, pulpa de fruta y puré de fruta, opcionalmente jugo de vegetales y/o de frutas no homogenizado, opcionalmente material vegetal y/o frutal no homogenizado y un éster de esterol de planta y/o éster de estanol de planta en una cantidad desde 0.2 hasta 25% por peso de la bebida. Adicionalmente la invención se refiere a un método para preparar la bebida estable.
Patent EC-SP900698-A (EC)
Title: Riboflavina como realzador del bronceado
Inventor: AGIN PATRICIA A
IPC: A61K8/14
Filed: 1990-11-07
Abstract: Se refiere a "un método para realzar la producción de melanina que comprende aplicar tópicamente a la piel una cantidad eficaz de una vitamina seleccionada del grupo que consiste en riboflavina, fosfato de riboflavina y mezclas de los mismos. Aquellos productos o sus mezclas se aplican en cantidades aficaces de manera que estimulan el incremento de producción de melanina. Pueden también aplicarse con solventes apropiados y otros ingredientes opcionales para ser aplicados como una composición. Al igual que en el caso de la Memoria de Trámite SP-90-697 afirman los proponentes que se ha descubierto en forma sorprendente que las aplicaciones tópicas -esta vez de riboflavina- en cantidades eficaces y como únioc ingrediente activo (es decir sin otras substancias como tirosina) son absorvidas por la piel para efectuar una producción de melanina incrementada por exposición de la piel a radiación UV.
Patent EC-SP951580-A (EC)
Title: Nuevo condensador de energia solar
Inventor: SANTANDER CERBELL ROBERTO
IPC: F24S90/00
Filed: 1995-11-10
Abstract: La presente invención se refiere a un nuevo condensador de energía solar, cuya evidente finalidad es como su propio nombre indica la realización de la condensación de energía solar para posteriormente ser utilizada en distintas aplicaciones. Esta invención tienen su aplicación dentro de la industria dedicada a la fabricación de útiles, aparatos y dispositivos destinados a ser utilizadops con la colaboración de la energía solar.
Patent FI-20070447-A (FI)
Inventor: TUOMAALA JORMA
IPC: F28G1/08
Filed: 2007-06-05
Abstract: The wall (1) has horizontally running impact bars (8) for blending impact energy on the wall and spaced at a distance from the wall. The bars are connected with vertically arranged fins with the wall, where the fins are flexibly designed over its extension between the wall and the bars in a lateral direction to accommodate different horizontal linear expansions of the wall and the bars. A lateral deflection is included for the fins corresponding to its flexible design in the lateral direction.
Patent FR-1602555-A (FR)
Title: A-furan steroids
IPC: C07J73/00
Filed: 1968-11-21
Granted: 1970-12-28
Abstract: A-oxasteroids (I) where S = an oestrane, pregnane, cholane, or cholestane residue, opt. substd. e.g. by OH, O acyl, alkylenedioxy, oxo, lower alkyl, lower alkenyl, lower alkynyl, opt. substd. NH2, CHO, CO2H, ether, ester, or lactone residues. and esp. (II) where X=C=O, CHOH, (where R = a (1-5C) hydrocarbon residue), -(1-11C) acyl, a ketal residue, or a pregnane, cholane or cholestane side chain. Anti-deciduomatogenic, anti-uterotrophic, anti-anabolic, anti-estrogenic, anti-androgenic, uterotrophic, contraceptic, and hypolipaemic. AlBui2 H (0.8 g.) in THF (4.7 ml.) was added to 17beta-acetoxy-3-oxa-A-noroestra-1 (10)-ene-2-one (517 mg.) in THF (14 ml.), at -20 to -25 deg. The mixture was stirred 20 mins., decompd. with 10% H2SO4 (a few drops), dild. with H2O, and extd. with CH2Cl2. The extract was washed, dried, and evapd., and the residue recryst. from Me2 CO-hexane, giving (I) (294 mg.), m.p. 137.5-139.5 deg.
Patent GB-1050797-A (GB)
IPC: B21D39/20
Abstract: 1,050,797. Tube expanders. SOCIETE DES FORGES ET ATELIERS DU CREUSOT. Sept. 10, 1964 [Sept. 13, 1963], No. 37145/64. Headings B3J and B3Q. A tube expanding tool comprises a sleeve 2 of deformable material mounted on a rod 1 between abutments 7, 8 which are movable towards each other to compress the sleeve axially and thus expand it radially. The sleeve consists of a variable number of rubber rings 2 and the abutments 7, 8 are provided respectively on a sleeve 4 screwed on the rod 1 and on a sleeve 9 secured to a hydraulic cylinder 11. Sleeves 4, 9 are slit at 6 to produce radial expansion of the abutments 7, 8. In order to expand a tube 19 into tight engagement with an aperture in a plate 20, the tube is fitted against an abutment surface 21 and the rod 1 is then moved axially by a piston 12 in cylinder 11 whose space 17 is supplied with pressure oil through ducts 16, 18. The piston is retracted by a spring 14.
Patent GB-1051874-A (GB)
IPC: C07C29/52
Abstract: 1,051,874. Hydrocarbon oxidation. IMPERIAL CHEMICAL INDUSTRIES Ltd. Aug. 12, 1963 [Aug. 14, 1962], No. 31160/62. Head. ing C2C. Alcohols are prepared by partially oxidizing a saturated hydrocarbon containing at least 3 carbon atoms in the liquid phase with a molecular oxygen containing gas at an elevated temperature in the presence of a borate or perborate salt to produce the borate ester of the alcohol and then hydrolysing said ester to the alcohol. The oxidation may be effected in the presence of, for example, ultra-violet light, ozone, organic peroxides and hydroperoxides, halogens, metal salt oxidation catalysts, and more readily oxidized organic compounds, e.g. aldehydes, ketones and secondary alcohols. Said oxidation may be effected in an inert solvent and at elevated pressures. The alcohol products are principally secondary alcohols.
Patent GB-1052056-A (GB)
IPC: H02K15/02
Abstract: 1,052,056. Coating surfaces; coating- apparatus. MINNESOTA MINING & MANUFACTURING CO. June 26, 1963 [June 26, 1962], No. 25497/63. Headings B2K and B2L. An insulating coating of a heat fusible material is applied to an article such as the stator of an electric motor by spraying particles of the coating material on to the article from opposite directions while the article is heated to a temperature sufficient to effect fusion of the particles deposited and an air stream is directed transversely to the direction of spraying to remove non-deposited particles. The coating material may comprise an epoxy resin. An apparatus described comprises opposed spray nozzles 17, 18 and means 13, 14 for supporting and rotating a stator 12 between the nozzles, the whole being enclosed in a chamber 10 from which air is exhausted at one end 11 so as to create a current of air at right angles to the nozzles. Additionally, air may be directed to or exhausted from the vicinty of the surface being coated.
Patent GB-1054376-A (GB)
IPC: C25D17/10
Abstract: 1,054,376. Power assisted steering. HYDROSTEER Ltd. June 26, 1964 [July 9, 1963], No. 26534/64. Divided out of 1,054,375. Heading B7H. The subject matter of this Specification is identical with that described in Specification 1,054,375.
Patent GB-1054980-A (GB)
IPC: C03B23/03
Abstract: 1,054,980. Bending glass sheets. LIBBEY-OWENS-FORD GLASS CO. Dec. 3, 1964, No. 49178/64. Heading C1M. Apparatus for bonding glass sheets 11 as they are moved by a conveyer along a predetermined substantially horizontal path extending between opposed complemental shaping surfaces 24, one formed on an upper mould part 22 disposed above the path and the other on a lower mould part 23 movable relative to the path toward and away from the upper mould part 22 thereby to press the sheets between the shaping surfaces, is characterized by the lower mould part 23 being pivoted about a fulcrum 58 on a carriage 31 disposed below the path to rock about an axis transverse to the path between a first position wherein the mould part 23 is inclined relative to and intersects the path and a second position wherein the lower mould part is disposed above and parallel to the path. A shoot 11 is conveyed from a heating zone A into a bending zone B and passes through the beam 41 of a sensing device. The leading edge of the sheet engages the downwardly inclined surface of the open ring type lower mould part 23. When the sheet is fully on the said mould part the mould part 23 is rocked about the fulcrum 58 into a horizontal position supporting the sheet 11 parallel to but above the conveyer 33. A solenoid operated actuator 62 may be eased to rock to mould part about the fulcrum. A cam disc 45 is then rotated and by means of a follower 43 attached to a parallel bars linkage the carriage 31 supporting the lower mould 23 is raised into pressing engagement with the stationary upper mould part 22. The lower mould with the bent sheet is then lowered to a position below the conveyer 33 so that it can be removed to a tempering section C. The shaping surface of the upper mould part 22 is substantially continuous and for protection is covered by a material 73, e.g. glass fibre, with a more resilient backing material 76. These I materials extend across the shaping surface. each from a substantially continuous supply and may be selectively drawn from said supplies across the shaping surface.
Patent GB-1074669-A (GB)
Abstract: 1,074,669. Electric meters. HONEYWELL Inc. June 14, 1966 [June 15, 1965], No.26507/66. Heading G1Q. A galvanometer movement is at least partly immersed in liquid and a sleeve 62 surrounding part of the immersed portion is axially movable to adjust the degree of liquid damping. As shown the movement is a torsionally suspended coil 20 and the liquid 60, e.g. a silicone, covers the coil but not the indicator mirror 18, Fig. 2 (not shown) carried by the suspension strip 22. The sleeve 62 surrounds part of the immersed coil and the proportion surrounded can be adjusted by sliding the sleeve up or down. A wire 66 attached to the sleeve may be used for this purpose: it can be secured in its adjusted position by soldering its end 68 to the casing. Fig. 2 (not shown) depicts the ends of the suspension strips 22 and 24 of Fig. 3 wrapped around bobbins (34, 26) one of which is adjustably positionable by means of a screw (40): this enables sensitivity and frequency response to be adjusted. Both suspension strips are connected to slack leads which are led out to a plug connector 48, Fig. 2 (not shown) at the free end of the tube 14. The casing Fig. 1 (not shown) consists of the tube 14 partly shown in Fig. 3 fitted with a tubular cap (12). Both casing parts have windows (70, Fig. 2 and 72, Figs. 1 and 2) which are placed in register to form a single viewing aperture through which the mirror is visible. The construction exemplified is suitable as the movement of one channel of a multichannel mirror oscillograph, e.g. of the kind described in U.S.A. Patent No. 2, 908, 866, in which a plurality of moving coil movements are mounted in a common magnet system.
Patent GB-1225386-A (GB)
IPC: H02H3/34
Filed: 1968-05-01
Abstract: 1,225,386. Protective arrangements. COMPAGNIE DES COMPTEURS. 1 May, 1968 [3 May, 1967], No. 20586/68. Heading H2K To provide reference signals for use in directional and distance relay elements, a filter Fa ... Fc is associated with each phase of a three system 1 ... 3 for deriving a signal representative of the postive sequence component of the supply voltage Va ... Vc of the associated phase, these signals being prolonged by resonant circuits Ma ... Mc tuned to the frequency of the protected system. The resonant circuits are formed by capacitors C<SP>1</SP> and the primary windings P of transformers Da ... Dc having secondary windings S connected in star to directional or phase-selecting relay elements (not shown).
Patent GB-1225528-A (GB)
IPC: B60R22/34
Filed: 1968-04-22
Abstract: 1,225,528. Safety belt clamping device. JIM ROBBINS SEAT BELT CO. 22 April, 1968 [21 April, 1967], No. 18857/68 Heading A3V. [Also in Division E2] A clamping device, Fig. 2, for a vehicle safety belt comprises a retracting means 30 for biasing the safety belt 18 toward a stored position, and clamping means 32 electrically operated to restrain the movement of the belt from its stored position, the electrical operation being by means of a switch, Fig. 5, which comprises a plurality of electrical terminals 88, 92 spaced from one another and extending into a chamber 86 and electrically conductive non-wetting liquid (preferably mercury) 90 partially filling the chamber and occupying an equilibrium position wherein the terminals are electrically disconnected, the liquid being displaceable from this position to one "D" where it bridges the electrical terminals to close a circuit and actuate the clamping means, i.e. solenoid 64, when a sudden force is applied to the vehicle. The clamping means is preferably mounted on a carriage 58, Fig. 2, having a surface such that roller 62 is pushed by plunger 66 of the solenoid 64 into engagement with the belt 18 clamping it between the carriage 58 and the wall 28 of the belt housing 22. An excessive pull on the belt causes carriage 58 to move in the direction of belt extension whereupon teeth 74 engage the lower surface 78 of the belt housing and act as an energy absorbing means by gouging grooves therein. In an alternative form of clamping means, Fig. 6, a roller 62 is pushed up an inclined plane 80 by solenoid 64 and causes a row of balls 79 to clamp the belt 18 between the wall of the housing 22 and the balls.
Patent GB-1227466-A (GB)
IPC: H01H36/00
Filed: 1968-10-31
Abstract: 1,227,466. Magnetic switches. INTERNATIONAL COMPUTERS Ltd. 6 Oct., 1969 [31 Oct., 1968], No. 51698/68. Heading H1N. A direction responsive switch comprises a disc 30 rotatable about its centre and having mounted thereon one or more arms such as 36, 38 which are free to pivot out one end off-set from the centre of the disc 30. When the disc is rotated in a clockwise direction the arms will be retained by gravity to rest against a rear word stop 24, 28 when an arm is being moved upward so that a magnet 32, 34 on the end of the arm will not pass close enough to a sealed magnetic reed contact unit 40 to effect operation thereof. When an arm is being moved downward it will fall so that its magnet 32, 34 moves along a path 50 to effect operation of a contact unit 42. On anticlockwise rotation the arm or arms will fall on the other side of the rotational axis to effect operation of contact unit 40 instead of contact unit 42.
Patent GB-1229863-A (GB)
IPC: B60V1/00
Filed: 1968-03-08
Abstract: 1,229,863. Gas cushion vehicles; rope railways. HOVERMARINE Ltd. 7 March, 1969 [8 March, 1968], No. 11340/68. Headings B7K and B7L. In a transport system for conveyance of passengers and/or freight between a pair of stations, a platform 5 is supported on one or more gas cushions and is guided by cable means 9 extending between the stations. The cable co-operates with pulleys 25, 26, 27, 28, the pulley 26 being driven by a driving unit 29 to propel the platform. The gas cushion is contained within a flexible skirt 8 comprising flexible wall members 17 of the type disclosed in Specification 1,043,351 and a loop 18 extending between points 19 on the wall members and points 20 on the platform 5, the inner upper portions of the wall members being attached to the undersurface of the platform at points 21. In a modification, Fig. 3, the cable 9 is effectively endless passing round pulleys 35, 36, the pulley 36 being rotated by an endless belt driven by a reversible engine to guide and propel the platform. In a further modification, the gas cushion is contained by a fluid curtain or by a combination of a fluid curtain and flexible skirt.
Patent GB-1231499-A (GB)
IPC: F16D3/40
Filed: 1968-08-21
Abstract: 1,231,499. Making universal joints. CAM GEARS Ltd. 16 July, 1969 [21 Aug., 1968], No. 39908/68. Heading B3A. [Also in Division F2] A spider for a universal joint comprises two pins 1, 2 joined to form a cross by means of a halving joint 3, 4 and enclosed by two cruciform casing members 11 and 12 so that the ends of the pins project from the casing members. The casing members are joined by a welding, brazing or suitable bonding operation along surfaces 9 and 10. The abutting surfaces 3, 4 of the halving joint may be brazed, welded or suitably bonded to each other and are preferably in a diametral plane of each of the pins.
Patent GB-1233074-A (GB)
IPC: A61H9/00
Filed: 1968-05-29
Abstract: 1,233,074. Apparatus for care of the legs. W. J. WERDING. 29 May, 1968 [31 May, 1967], No. 25730/68. Heading A5R. Apparatus for therapeutic care of the legs, (a preferred form of which is illustrated in Fig. 1) comprises compression boots (1, 2) having an inflatable double wall, the inner wall of the boots having a non-uniform thickness, which thickness is greater in the proximal part than in the distal part of the boots, the boots being supported on a variable inclination pneumatic support in such a manner that the level of the distal part of the boots can be altered in relation to the level of the proximal part; and means for controlling the inflation of the boots and of the support. In the preferred form, the boots are employed with a special chair (5) provided with a control box (6) carrying control buttons (7, 8), by means of which inflation and deflation of the boots and support can be independently controlled through electrically and valve-controlled pump circuits. The pneumatic support for the boots preferably consists of a pneumatic cushion (3) positioned on a support (4), the cushion suitably comprising a plurality of chambers (31-33) connected by valves (V 2 , V 3 ) as shown in Fig. 3. Fig. 2 shows the cushion in completely deflated position while Fig. 3 shows it completely inflated. The apparatus is used to improve venous flow in the legs and the pressure created by the inflated boots on the legs is greater in the distal part than in the proximal because of the prescribed variation in wall thickness of the boots; this avoids obstructing the blood flow in the veins at thigh level.
Patent GB-1252347-A (GB)
IPC: B01J8/06
Filed: 1969-02-21
Abstract: 1,252,347. Distributing fluid in tubular heat exchangers. DEGGENDORFER WERFT UND EISENBAU G.m.b.H. 21 Feb., 1969 [12 March, 1968], No. 9389/69. Heading F4S. In tubular heat exchangers fluid entering in the direction A is distributed evenly across the heat exchanger, by distributing arrangements to be described, to take into account pressure differences. The arrangement shown in Fig. 3 comprises a plurality of rows of apertures 4, 5, 6 formed in a plate 3 which is adapted to receive tubes 1 extending between end plates 2. Fluid entering in direction A is distributed through the apertures 4, 5, 6 which have the same outlet diameter d but which have admission inlets progressively increasing in size across the surface of the plate. In an alternative form (Fig. 4, not shown) the apertures surround the tubes 1. For distribution of liquid to a plurality of heat exchange tubes an arrangement as shown in Fig. 5 is utilized. Plugs 22, 23, 24 containing apertures which are equal in diameter at their narrowest point but have different diameters at their admission end are inserted into the upper ends of the tubes. The inlet diameters increase as shown to compensate for pressure differences existing across the arrangement of tubes.
Patent GB-1257415-A (GB)
IPC: C07C275/30
Filed: 1970-03-09
Abstract: 1,257,415. Urea derivatives. FARBWERKE HOECHST A.G. 9 March, 1970 [7 March, 1969], No. 11139/70. Heading C2C. Novel urea derivatives of the general formula wherein R is an alkyl or cycloalkyl radical having from 2 to 4 carbon atoms and from 4 to 7 halogen atoms, at least two of which are fluorine atoms, R 1  is a hydrogen or chlorine atom, and R 2  is a hydrogen atom, or a methyl or methoxy group, are prepared by reacting either (a) a correspondingly substituted halogeno (cyclo) alkylphenyl isocyanate or halogeno (cyclo) alkyl-carbanilic acid chloride with either (i) methyl- or dimethyl-amine or with o-methyl- or O,N - dimethyl - hydroxylamine, (ii) o - methylhydroxylamine or N - methyl - hydroxylamine with subsequent alkylation of the reaction product at 10 to 90 C., or (iii) hydroxylamine - with subsequent dialkylation of the reaction product at 10 to 90 C., or (b) a correspondingly substituted halogeno (cyclo) alkyl-aniline with either (i) methyl isocyanate or dimethylcarbamic acid chloride, or (ii) dimethyl- or methylmethoxy-carbamic acid phenyl ester. The products may be used as herbicides.