Patent SG-11201804577R-A (SG)
Title: Fgf21 variants
Inventor: SOMMERFELD MARK
IPC: C07K14/50
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DEEM II 11111111111H Ill IIIIIIII (43) International Publication Date 8 June 2017 (08.06.2017) (10) International Publication Number WO 2017/093465 Al WIPO I PCT (51) International Patent Classification: C07K 14/50 (2006.01) A61K 38/26 (2006.01) A61K 38/18 (2006.01) A61K 38/28 (2006.01) (21) International Application Number: PCT/EP2016/079551 (22) International Filing Date: 2 December 2016 (02.12.2016) English English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 15306913.3 2 December 2015 (02.12.2015) EP (71) Applicant: SANOFI [FR/FR]; 54, rue La Boetie, 75008 Paris (FR). (72) Inventors: SOMMERFELD, Mark; c/o Sanofi-Aventis Deutschland GmBH, Industriepark Hochst, Building K703, 65926 Frankfurt (DE). LANGER, Thomas; c/o San- ofi-Aventis Deutschland GmBH, Industriepark Hochst, Building K703, 65926 Frankfurt (DE). BOSCHEINEN, Oliver; do Sanofi-Aventis Deutschland GmBH, Indus- triepark Hochst, Building K703, 65926 Frankfurt (DE). DREYER, Matthias; c/o Sanofi-Aventis Deutschland GmBH, Industriepark Hochst, Building K703, 65926 Frankfurt (DE). DITTRICH, Werner; c/o Sanofi-Aventis Deutschland GmBH, Industriepark Hochst, Building K703, 65926 Frankfurt (DE). (72) Inventor: HABERMANN, Paul (deceased). (74) Agent: BOHMER, Thomas; Radlkoferstr. 2, 81373 Mfinchen (DE). W O 20 17 /093 465 Al (54) Title: FGF21 VARIANTS (57) : The present invention relates to polypeptide variants of human fibroblast growth factor 21 (FGF21) and fusion mo- lecules thereof, as well as to nucleic acid molecules encoding the same. It further relates to their use as medicaments, in particularfor the treatment of obesity, overweight, metabolic syndrome, diabetes mellitus, hyperglycemia, dyslipidemia, non-alcoholic steatohep - atitis (NASH) and/or atherosclerosis.