baber/WOPTO huggingface dataset:
Patent ES-2183132-T3 (ES)
Inventor: HENDRICKS JUDY K
IPC: G01N31/22
Filed: 1997-01-22
Granted: 2003-03-16
Abstract: This invention relates to novel apparatus and methods for inserting and positioning a compressible material into a container and for using the container for detecting a specific environmental parameter or combination of parameters and for determining the effectiveness of a sterilization procedure. Precise positioning of a plug of compressible material in a container provides flexibility for production of indicator systems that vary in their response to sterilizing conditions. These indicators reflect the efficacy of sterilizers based on different modes of sterilization and reproduceability for accurate monitoring of each mode. The invention also relates to test indicators containing controlled volumes of compressed, gas-permeable materials and to methods for using test indicators for determining the efficacy of different types of sterilization processes. The test indicator consists of a plurality of interactive enzymes in a container with at least one opening. The opening is filled with a compressed cylindrical foam insert and the test indicator is placed into the sterilization chamber. The foam insert regulates the amount of sterilant such as steam, gas, chemicals or plasma entering the test indicator. Upon proper sterilization, the sterilant destroys the interactive enzymes and no color product is formed. Inactivation of the enzyme system parallels the inactivation of bacterial spores subjected to the sterilization process. Results are available in from a few seconds to a few hours. The test indicator can also be placed into a container with material such that the design simulates an environmental parameter test of the sterilization process.
Patent ES-2229331-T3 (ES)
Inventor: SCHERZ MICHAEL WIARD
IPC: C07D335/06
Filed: 1997-01-30
Granted: 2005-04-16
Abstract: A compound having the structure:   <IMAGE>   wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) W is O or S; and (f) R1, R2 and R3 are independently hydrogen, straight, branched or cyclic alkyl having from 1 to 10 carbon atoms, aryl, heterocyclyl, heteroaryl, hydroxy, or alkoxy; or R1, R2 or R3 may be bonded to form one or more rings each ring having from 3 to about 7 atoms wherein from 1 to 3 atoms may be heteroatoms. pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Patent ES-2227674-T3 (ES)
Title: Composiciones en polvo a base de poliesteres semicristalinos y de copolimeros acrilicos, que contienen grupos etilenicamente insaturados.
Inventor: MOENS LUC
IPC: C08F2/46
Filed: 1997-10-24
Granted: 2005-04-01
Abstract: COMPOSICIONES EN POLVO ENDURECIBLES POR RADIACION UTILIZABLES COMO PINTURA O BARNIZ QUE COMPRENDEN UNA MEZCLA DE AL MENOS UN POLIESTER SEMICRISTALINO QUE CONTIENE GRUPOS METACRILOILO TERMINALES Y DE AL MENOS UN COPOLIMERO ACRILICO QUE CONTIENEN GRUPOS ETILENICAMENTE INSATURADOS, COMPRENDIENDO ESTOS POLIESTERES LOS PRODUCTOS DE REACCION DE UN METACRILATO DE GLICIDILO Y DE UN POLIESTER SEMICRISTALINO O AMORFO QUE CONTIENE GRUPOS CARBOXILO TERMINALES.
Patent ES-2182066-T3 (ES)
Inventor: ZHANG YUN PO
IPC: A61K8/64
Filed: 1997-04-14
Granted: 2003-03-01
Abstract: Oral composition comprises a dental vehicle, a casein glycomacropeptide to provide antibacterial activity, an anionic surfactant and a hydrolysed protein compound to stabilise the antibacterial activity of the macropeptide in the presence of the surfactant. Also claimed is a method of preparing the oral composition which comprises adding a casein glycomacropeptide, an anionic surfactant and a hydrolysed protein compound to an aqueous vehicle and mixing the mixture to obtain a stable composition. The hydrolysed protein stabiliser preferably comprises hydrolysed collagen protein, especially quaternary derivative or food grade gelatin prepared from boiled animal parts. The hydrolysed protein comprises 0.1-2.5 wt% and the glycomacropeptide comprises 0.5-10 wt% of the composition. The glycomacropeptide is a kappa-casein glycopeptide or its desialyated derivatives. The anionic surfactant is sodium lauryl sulphate. The composition, in the form of a toothpaste comprises 30-75wt% water-insoluble polishing agent (especially silica), in the form of a toothpowder comprises 70-80% hydrated alumina, in the form of an aqueous mouthwash comprises 5-10% ethanol and in the form of a chewing gum comprises 20-30% natural or synthetic elastomer filler.
Patent ES-2165059-T3 (ES)
Title: Sistema de gestion termica para un dispositivo de proyeccion.
Inventor: RODRIGUEZ ERNESTO M
IPC: G03B21/16
Filed: 1997-05-21
Granted: 2002-03-01
Abstract: SISTEMA DE GESTION DE LA ENERGIA TERMICA QUE PUEDE UTILIZARSE EN UN DISPOSITIVO COMPACTO DE VISUALIZACION. SE PROPORCIONA UN CONDUCTO (32) DENTRO DEL ALOJAMIENTO DE LA LAMPARA DEL DISPOSITIVO DE VISUALIZACION, Y SE MONTA UNA FUENTE DE LUZ DE ELEVADO VATIAJE (30) DENTRO DEL CONDUCTO. AL MENOS EN UNA SUPERFICIE INTERIOR DEL CONDUCTO, Y EXTENDIENDOSE EN EL INTERIOR DEL MISMO, SE MONTAN MULTIPLES ALETAS DE REFRIGERACION (33). UN REVESTIMIENTO ABSORBENTE DE LA RADIACION TERMICA, COMO UNA ANODIZACION EN NEGRO, CUBRE EL INTERIOR DEL CONDUCTO Y LAS ALETAS DE REFRIGERACION, Y PERMITE UNA MAYOR ABSORCION SUPERFICIAL DE LA RADIACION TERMICA. UN ORIFICIO SITUADO DENTRO DEL CONDUCTO, QUE ES TRANSPARENTE A LA LUZ VISIBLE, SE UTILIZA PARA DIRIGIR LA LUZ VISIBLE A TRAVES DE UN CONJUNTO DE VISUALIZACION (40). UN FILTRO DE INFRARROJOS (38), QUE PUEDE REFLEJAR O ABSORBER LA RADIACION INFRARROJA, COMO EL DENOMINADO ESPEJO CALIENTE, SE UTILIZA PARA MANTENER LA RADIACION TERMICA DENTRO DEL CONDUCTO, Y, A CONTINUACION, SE UTILIZA UN VENTILADOR (55) PARA HACER PASAR FLUIDO DE REFRIGERACION A TRAVES DEL CONDUCTO, PASANDO EL FLUIDO DE REFRIGERACION SOBRE LAS ALETAS DEL CONDUCTO Y RETIRANDO LA ENERGIA TERMICA DEL DISPOSITIVO DE VISUALIZACION DE MANERA ALTAMENTE EFICIENTE.
Patent ES-2173450-T3 (ES)
Inventor: OVREBO KJELL
IPC: H02J13/00
Filed: 1997-06-04
Granted: 2002-10-16
Abstract: PCT No. PCT/NO97/00141 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Jun. 4, 1997 PCT Pub. No. WO97/47066 PCT Pub. Date Dec. 11, 1997In a method for temperature and time control of electrical heating devices installed at an end user to optimize energy consumption and energy costs, where a dedicated control system is employed for the control, a local control unit is connected to an electrical heating device for control thereof. The end user supplies a desired user profile for the heating device to the control system which optimizes energy and power consumption on the basis of both the user profile and the operating and capacity conditions in the power supply network. The control commands are transferred to the local control unit. In addition to a dedicated control system for implementation of the method, a control and communication structure includes local control units installed at end users and one or more communication interfaces.
Patent ES-2152095-T3 (ES)
Inventor: MCFADDEN D GRANT
IPC: A61P31/04
Filed: 1997-05-21
Granted: 2001-01-16
Abstract: The present invention provides a method of use for a novel chemokine binding protein (type-2 CBP) encoded by poxviruses and having amino acid sequence homology with the Shope fibroma virus T1 family of proteins against disease syndromes associated with acute or chronic dysregulated inflammatory responses.
Patent ES-2166116-T3 (ES)
Title: Casco protector, en particular casco protector militar.
Inventor: ZAHN CHRISTIAN
IPC: A42B3/08
Filed: 1998-05-02
Granted: 2002-04-01
Abstract: EN UN CASCO DE PROTECCION, ESPECIALMENTE CASCO DE PROTECCION MILITAR, CON UNA CASCARA DEL CASCO DURA (1), UN EQUIPAMIENTO INTERIOR AMORTIGUADOR DE GOLPES CON UNA BANDA PARA LA CABEZA (22), SOBRE LA QUE SE FIJAN LAS PIEZAS DEL EQUIPAMIENTO INTERIOR PREVISTAS PARA CONTACTAR CON LA CABEZA DEL PORTADOR DEL CASCO, Y CON UN CONJUNTO DE CINTA DE BARBILLA (18), FIJADO EN AL MENOS SUS DOS EXTREMOS (19) SOBRE LA CASCARA DEL CASCO (1), CUYOS EXTREMOS (19) PUEDEN UNIRSE ENTRE SI MEDIANTE UN CIERRE DE LA CINTA DE BARBILLA, PARA LA FIJACION DEL CASCO SOBRE LA CABEZA DEL PORTADOR DEL CASCO, ES POSIBLE DESMONTAR FACILMENTE LAS PIEZAS QUE ESTAN EN CONTACTO CON LA CABEZA DEL PORTADOR DEL CASCO POR MOTIVOS HIGIENICOS SIN DESMONTAR EL CASCO DE PROTECCION COMPLETO, YA QUE LA BANDA DE CABEZA (22) SE FIJA POR INSERCION EN LA CASCARA DEL CASCO (1), MONTANDOSE PARA LA BANDA DE CABEZA (22) UNA PIEZA DE CIERRE POR INSERCION (10) SOBRE LA CASCARA DEL CASCO (1) EN AL MENOS UN PUNTO DE FIJACION, EN LA QUE PUEDE INSERTARSE Y BLOQUEARSE LA PIEZA DE CIERRE COMPLEMENTARIA (15) UNIDA A LA BANDA DE CABEZA (22), Y AL FIJARSE CON POSIBILIDAD DE DESMONTAJE EL CONJUNTO DE CINTA DE BARBILLA (18) SOBRE EL PUNTO DE FIJACION COMUN CON LA BANDA DE CABEZA (22).
Patent ES-2162415-T3 (ES)
Title: Desvolatilizacion en estado solido de polimeros vinilaromaticos sindiotacticos con desactivacion catalitica.
Inventor: BILLOVITS GERALD F
IPC: C08F12/00
Filed: 1998-01-30
Granted: 2001-12-16
Abstract: Un procedimiento de desvolatilización de un polímero en estado sólido, que comprende calentar una mezcla de alimentación húmeda que comprende un polímero vinil-aromático sindiotáctico, componentes volátiles y catalizador activo residual, a una temperatura comprendida entre la temperatura de transición vítrea y el punto de fusión del polímero, en presencia de un gas desactivador de catalizador, en el que la corriente de alimentación no se pone en contacto con nitrógeno o aire hasta que se alcanza el nivel deseado de componentes volátiles.
Patent ES-2229483-T3 (ES)
Inventor: FANARA DOMENICO
IPC: A61K9/22
Filed: 1998-03-13
Granted: 2005-04-16
Abstract: The invention relates to pharmaceutical compositions which can be administrated orally, allowing the controlled release of at least one active substance comprising a) the said at least one active substance, b) between 5 and 60% by weight, relative to the total weight of the composition, of at least one excipient, selected from inert matrices, hydrophilic matrices, lipid matrices, mixtures of inert matrices and of lipid matrices, mixtures of hydrophilic matrices and of inert matrices, with the exception of mixtures comprising a polyacrylic acid and at least one hydrophilic matrix of the cellulose type; c) between 5 and 50% by weight, relative to the total weight of the composition, of at least one alkalinizing agent soluble in an aqueous phase under physiological pH conditions, selected from alkali or alkaline-earth metal hydroxidcs, carbonates, bicarbonates and phosphates, sodium borate as well as the basic salts of organic acids. It also relates to processes for the preparation of said compositions, multi-layered pharmaceutical compositions comprising at least one layer with this composition, as well as processes for the preparation of said multi-layered composition.
Patent ES-2182355-T3 (ES)
Inventor: RODRIGUEZ GUSTAVO A
IPC: A23K1/16
Filed: 1998-07-17
Granted: 2003-03-01
Abstract: A method of isomerizing lutein to yield a mixture of epimers of zeaxanthin includes the following steps: mixing a lutein-containing extract in a glycol solution to obtain a mixture, treating the mixture with alkali to obtain an alkali-containing mixture, reacting the alkali-containing mixture in the presence of heat for a duration consistent with achieving a desired level of isomerization of lutein to zeaxanthin.
Patent ES-2322825-T3 (ES)
Title: Mutantes de alfa-amilasa.
Inventor: SVENDSEN ALLAN
IPC: C12N15/09
Filed: 1998-10-13
Granted: 2009-06-29
Abstract: Una variante de una {alpha}-amilasa parental tipo Termamyl, donde la {alpha}-amilasa parental tipo Termamyl es seleccionada entre: (i) SEC ID NO: 1, SEC ID NO: 2, SEC ID NO: 3, SEC ID NO: 4, SEC ID NO: 5, SEC ID NO: 6, SEC ID NO: 7 o SEC ID NO: 8; (ii) una {alpha}-amilasa parental tipo Termamyl que tiene al menos el 80% de homología para una de las secuencias en (i); y donde la variante tiene actividad {alpha}-amilasa y comprende las mutaciones siguientes 1181* y G182* y N193F en SEC ID NO: 3 o en posiciones correspondientes en otra {alpha}-amilasa parental tipo Termamyl.
Patent ES-2325232-T3 (ES)
Inventor: ZAUGG ALAIN
IPC: F16H1/28
Filed: 1999-08-04
Granted: 2009-08-28
Abstract: Winding indicator has a simple differential planetary gear train (10) with input (8) from an arming wheel (6) driven by the cylinder center and a second input (14) from a disarming wheel (12) driven from the outside of the cylinder with output wheel (16) driving an indicator wheel (18).
Patent ES-2235413-T3 (ES)
Inventor: KWAN-HO LEE
IPC: F24C7/02
Filed: 1999-08-23
Granted: 2005-07-01
Abstract: A heater cover for microwave ovens using halogen heaters in addition to magnetrons is disclosed. The above heater cover is designed to have an optimal opening ratio while effectively protecting the halogen heaters from microwaves and having a desired structural strength. On the heater cover, a plurality of perforations are formed along a plurality of rows with both the same interval between the perforations and a radius "r" of each perforation being three times or more of the interval. The interval between horizontal phantom lines, passing through the centers of the perforations arranged on the rows, is shorter than the diameter "2r" of each perforation. The relation between the radius "r" of each perforation and the wavelength " lambda " of microwaves is expressed by the expression, lambda /64 ≤ 2r ≤  lambda /8. The interval between the perforations ranges from 0.5 mm to 2 mm. <IMAGE>
Patent ES-2174561-T3 (ES)
Inventor: PLUMLEY BRUCE A
IPC: B41J11/42
Filed: 1999-10-04
Granted: 2002-11-01
Abstract: In an apparatus (10, 110, 210, 310) for printing on a continuously moving sheet of work material (15, 115, 215, 315), a frame (12, 112) is provided and defines a work supporting surface (14, 114, 214) over which a sheet of work material is advanced in a first coordinate direction longitudinally of itself. An elongated support (16, 116, 216, 316) is mounted to the frame (12, 112) and extends transversely across the work supporting surface (14, 114, 214). A print head (28, 128, 228, 328) is mounted to the elongated support (16, 116, 216, 316) and is movable across the support, as well as between a forward and rearward position. During operation, as the work material (15, 115, 215, 315) is continuously advanced through the apparatus (10, 110, 210, 310), the print head (28, 128, 228, 328) traverses the support (16, 116, 216, 316) and simultaneously moves between the forward and rearward positions, such that the print head has a component of speed in the first coordinate direction approximately equal to the rate at which the work material is advanced. This causes the print head (28, 128, 228, 328) to print successive lineal portions of a graphic oriented approximately perpendicular to the first coordinate direction while the work material (15, 115, 215, 315) is continuously advanced. <IMAGE>
Patent ES-2276501-T3 (ES)
Inventor: GERS-BARLAG HEINRICH DR
IPC: A61K8/60
Filed: 1999-12-08
Granted: 2007-06-16
Abstract: Stabilization of cosmetic oil-in-water emulsions containing at least one polar UV-filter and/or polar oil, by addition of boronitride. Cosmetic or dermatological oil-in-water (O/W) emulsions containing at least one boronitride and at least one polar UV-filter substance and/or polar oil component are new.
Patent ES-2217680-T3 (ES)
Inventor: GU JIREN DR
IPC: B41M5/52
Filed: 1999-12-17
Granted: 2004-11-01
Abstract: Recording material for ink-jet printing comprises base paper and an ink-receiving layer applied from aqueous dispersion or solution, in which the base paper is coated with an extruded layer containing an extrudable polyvinyl alcohol (PVAL).  An Independent claim is also included for a process for the production of ink-jet recording material from base paper with a surface roughness (Sheffield) of less than 300, by melt-extrusion of a PVAL homo- and/or copolymer from an extruder with zone temperatures of 140-230 degrees C and at a screw speed such that the viscosity of the melt corresponds to the melt viscosity of a PVAL processed in a 2-inch screw extruder at 140-230 degrees C with a screw speed of more than 50 r.p.m., passing the molten polymer into the gap between the paper and a highly-polished cooling cylinder and then coating the extruded PVAL layer with an ink-receiving layer from aqueous solution or dispersion.
Patent ES-2257021-T3 (ES)
Inventor: DE FRUTOS ESCRIG PILAR
IPC: C07D303/04
Filed: 1999-08-06
Granted: 2006-07-16
Abstract: Alkene oxides are produced in a continuous integrated two-step process performed in liquid phase. Step I comprises the oxidation of a secondary alcohol with molecular oxygen to generate hydrogen peroxide at moderate temperature and pressure. This reaction mixture is introduced directly to an olefmic substrate maintained in organic solvent at elevated pressure. During step II of the procedure the olefins undergo epoxidation by the hydrogen peroxide in the presence of a catalyst of titanium-impregnated, amorphous silica. The integrated process requires no intermediate purification or enrichment step and it is particularly well adapted to the production of propylene oxide.  <IMAGE>
Patent ES-2215374-T3 (ES)
Title: Metodo para la fabricacion de articulos antimicrobianos.
Inventor: LYON KEITH R
IPC: B05D1/40
Filed: 1999-01-29
Granted: 2004-10-01
Abstract: Un método para el tratamiento de un sustrato para proporcionar un artículo antimicrobiano, comprendiendo el método las etapas de: a) proporcionar un sustrato b) preparar una solución que comprende un polímero quelante y un ión metálico, en la que el ión metálico forma enlaces o complejos con el polímero quelante; c) recubrir dicha solución sobre el sustrato; d) secar el sustrato recubierto; e) tratar el sustrato recubierto seco con otra solución que comprende un potenciador para formar el artículo antimicrobiano, en la que el potenciador es un agente antimicrobiano capaz de unirse al ión metálico.
Patent ES-2268850-T3 (ES)
Title: Elaboracion de te.
Inventor: GOODSALL CHRISTOPHER WILLIAM
IPC: A23F3/08
Filed: 1999-02-04
Granted: 2007-03-16
Abstract: Un procedimiento para elaborar té negro, que comprende fermentar hojas de té no maceradas, tostar las hojas para detener la fermentación y secar las hojas para que resulte té negro en hoja, procedimiento que se caracteriza porque la fermentación se inicia por calentamiento de las hojas de té no maceradas a una temperatura entre 38ºC y 60ºC durante de 0, 5 a 10 minutos.
Patent ES-2189401-T3 (ES)
Title: Sistema interactivo de seleccion para un canal modulador de un receptor de video.
Inventor: PUGEL MICHAEL ANTHONY
IPC: H04N5/76
Filed: 1999-03-03
Granted: 2003-07-01
Abstract: Un método para sintonizar un receptor de señal de vídeo a un accesorio de vídeo, tal como un receptor de TV, que incluye un dispositivo de procesamiento de imagen, para que sea compatible con un sistema receptor de vídeo, que comprende las etapas de: generar un mensaje de aviso para visualizarse para incitar a un usuario a iniciar una respuesta de mando; generar una primera y segunda señales de salida, cada una de dichas señales de salida incorporando dicho mensaje de aviso, y estando solamente una de dichas señales de salida sintonizada de forma compatible a dicho dispositivo de procesamiento de imagen; suministrar alternativamente dicha primera y dicha segunda señales de salida a dicho dispositivo de procesamiento de imagen para mostrar de forma legible dicho mensaje de aviso cuando una de dichas señales de salida suministradas es sintonizada de forma compatible con dicho dispositivo de procesamiento de imagen; y seleccionar dicha señal de salida compatible en respuesta a dicha orden de mando.
Patent ES-2196806-T3 (ES)
Title: Derivados de fenilurea y de feniltiourea.
Inventor: JOHNS AMANDA
IPC: C07D471/04
Filed: 1999-05-04
Granted: 2003-12-16
Abstract: 1. Un compuesto de fórmula (I): en la cual: uno de X e Y es N, y el otro es CH; Z representa oxígeno o azufre; R1 representa alquilo(C1-6), alquenilo(C2-6) o alcoxi(C1-6); halógeno, R7CO- ó NR8R9CO-; R2, R3, R4, R5 y R6 representan independientemente alquilo(C1-6), alquenilo(C2-6), alcoxi(C1-6) o tioalquilo(C1-6); hidrógeno, halógeno, nitro, ciano, fenoxi, naftiloxi, fenilalcoxi(C1-6), naftilalcoxi(C1-6), fenilalquilo(C1-6), naftilalquilo(C1-6), R7CO-, R7SO2NH-, R7CON(R10)-, NR8R9-, NR8R9CO-, -COOR8, un anillo monocíclico o bicíclico de 5 a 10 miembros, que puede estar insaturado o saturado, que contiene 1 a 3 heteroátomos seleccionados entre oxígeno, nitrógeno o azufre, o un alquilo(C1-6) sustituido con un anillo monocíclico o bicíclico de 5 a 10 miembros, que puede estar insaturado o saturado, que contiene 1 a 3 heteroátomos seleccionados entre oxígeno, nitrógeno o azufre; o un par adyacente de R2, R3, R4, R5 y R6 junto con los átomos de carbono a los cuales están unidos, forman un anillocarbocíclico o heterocíclico aromático o no aromático de 5 a 7 miembros, en el que el anillo heterocíclico contiene 1, 2 ó o 3 heteroátomos seleccionados entre oxígeno, nitrógeno y azufre, y en el que el anillo carbocíclico o heterocíclico puede estar insustituido o sustituido en el carbono o nitrógeno con uno o más sustituyentes seleccionados entre =O, alquilo(C1-4), fenilalquilo(C1-4), naftilalquilo(C1-4), fenilo, naftilo, alcoxi(C1-4), alcoxi(C1-4)alquil(C1-4)hidroxi, hidroxialquilo(C1-4), RaCO2-, RaCO2alquilo(C1-4), ciano, cianoalquilo(C1-4), RaRbN y RaRbNalquilo(C1-4); en el cual, Ra y Rb son independientemente seleccionados entre hidrógeno y alquilo(C1-4); R7 es alquilo(C1-6), fenilo o naftilo; R8 y R9 representan independientemente hidrógeno, alquilo (C1-6), fenilo, naftilo, fenilalquilo(C1-6) o naftilalquilo(C1-6); R10 es hidrógeno o alquilo(C1-6); y n es 0, 1, 2 ó 3; en donde alquilo puede ser una cadena lineal, ramificada o cíclica; o una sal farmacéuticamente aceptable del mismo.
Patent ES-2260918-T3 (ES)
Inventor: KIM SUNYOUNG
IPC: C12N7/01
Filed: 1999-06-24
Granted: 2006-11-01
Abstract: The present invention relates to improved retroviral vectors for gene therapy. In this invention, retroviral vectors with higher safety and efficiency are constructed from MLV-based starting vectors, MON and MIN. The improved vectors have the following features: 1) sequences corresponding to MLV-derived pol gene are completely deleted in the vectors, avoiding homologous recombination which has been a baffling problem in conventional retroviral vectors, 2) a heterologous intron, splicing acceptor and/or non-coding sequence are/is inserted into the upstream position of a cloning site, maximizing the expression of a foreign gene through efficient splicing, 3) the vectors contain either the full-length U3 sequence of 5' LTR or a strong heterologous promoter instead, permitting the abundant production of RNA, 4) either IRES (Internal Ribosomal Entry Site) or internal SV40 minimal promoter is inserted into the downstream position of cloning site, enabling the simultaneous expression of two or more foreign genes. Since the improved retroviral vectors of this invention turn out to be safe and to express the foreign gene efficiently, they are useful for gene therapy and the like.