baber/WOPTO huggingface dataset:
Patent CA-3118393-A1 (CA)
Title: High-throughput optical sectioning three-dimensional imaging system
Inventor: LUO QINGMING
IPC: G02B21/00
Filed: 2019-07-30
Abstract: The present disclosure discloses a high-throughput optical sectioning three-dimensional imaging system which includes: a light beam modulation module configured to modulate a light beam into a modulated light beam capable of being focused on a focal plane of an objective lens and being defocused on a defocusing plane of the objective lens;  an imaging module configured to employ a camera to image, in different rows of pixels, a sample under illumination of the modulated light beam; a cutting module configured to cut off an imaged surface layer of the sample; a demodulation module configured to demodulate a sample image of one sample strip of one surface layer into an optical sectioning image, and reconstruct the optical sectioning image of each sample strip of each surface layer into a three-dimensional image. The present disclosure achieves imaging of a whole sample by dividing the sample into at least one surface layer, dividing the at least one surface layer into at least one sample strip, and imaging each sample strip. When a multi-layer imaging cannot be performed, the imaged part can be cut off by the cutting module to realize imaging of any layer of the sample, thereby improving the imaging speed and efficiency.
Patent CA-3119041-A1 (CA)
Title: Biodegradable tissue replacement implant and its use
Inventor: MANINISHKIS ARVYDAS
IPC: A61L27/54
Filed: 2019-11-18
Abstract: Tissue replacement implants are disclosed that include polarized retinal pigment epithelial cells on a poly(lactic-co-glycolic acid) (PLGA) scaffold, wherein the PLGA scaffold is 20-30 microns in thickness, has a DL-lactide/glycotide ratio of about 1:1, an average pore size of less than about 1 micron, and a fiber diameter of about 150 to about 650 nm. Also disclosed are methods of treating a subject with a retinal degenerative disease, retinal or retinal pigment epithelium dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium. These methods include locally administering to the eye of the subject the tissue replacement implant. In further embodiments, methods are disclosed for producing the tissue replacement implant.
Patent CA-3119511-A1 (CA)
Title: Joint d'interface pour interconnecter un generateur electrochirurgical et un instrument electrochirurgical
Inventor: HANCOCK CHRISTOPHER PAUL
IPC: A61B18/18
Filed: 2019-11-19
Abstract: L'invention concerne un joint d'interface pour interconnecter un générateur électrochirurgical et un instrument électrochirurgical, le joint d'interface comprenant : un boîtier ayant : une entrée pour recevoir de l'énergie électromagnétique provenant du générateur électrochirurgical, et une sortie ; un déclencheur coulissant sur le boîtier, le déclencheur coulissant étant fixé à une tige de poussée qui s'étend hors du boîtier à travers la sortie ; et un ensemble câble unique pour connecter la sortie à l'instrument électrochirurgical, l'ensemble câble unique comprenant un manchon souple qui transporte la tige de poussée et un câble coaxial qui est relié à l'entrée. Le joint d'interface peut comprendre un élément de renfort couplé à une première partie de la tige de poussée de façon à renforcer la première partie. En outre ou en variante, le joint d'interface peut comprendre un mécanisme de limitation de coulissement couplé à la tige de poussée et configuré pour limiter une distance de coulissement maximale d'un tube interne sur la tige de poussée.
Patent CA-3120249-A1 (CA)
Title: Method of generating an aerosol comprising protonated nicotine
Inventor: BRUTON CONNOR
IPC: A24F40/05
Filed: 2019-11-15
Abstract: There is provided a method of generating an aerosol comprising protonated nicotine, the method comprising the steps of: (i) providing a nicotine formulation comprising nicotine as free base; (ii) providing a carbon dioxide source capable of providing carbon dioxide in situ; (iii) vaporising or aerosolising the nicotine formulation; (iv) providing carbon dioxide from the carbon dioxide source, and (v) contacting the carbon dioxide with the vaporised or aerosolised nicotine formulation to thereby protonate nicotine free base and generate an aerosol comprising protonated nicotine.
Patent CA-3120281-A1 (CA)
Title: Systems and methods for facilitating clone selection
Inventor: YUAN YU
IPC: G06V10/764
Filed: 2019-11-26
Abstract: A method for facilitating clone selection includes generating time-sequence images of a well containing a medium, including a first image and a later, second image. The method also includes detecting, by one or more processors analyzing the first image, one or more candidate objects depicted in the first image, and, for each of the candidate objects, determining whether the object is a single cell by analyzing an image of the object using a convolutional neural network. The method further includes detecting, by analyzing the second image with the processor(s), a cell colony depicted in the second image, and determining, by the processor(s), whether the colony was formed from only one cell based at least on whether each candidate object was determined to be a single cell. The method further includes generating, by the processor(s), output data indicating whether the colony was formed from only one cell.
Patent CA-3121919-A1 (CA)
Title: System and method for augmenting database applications with blockchain technology
Inventor: QIAN YUMING
IPC: G06F16/27
Filed: 2019-11-28
Abstract: A method for augmenting a database application with blockchain technology is disclosed. The method involves recording data modifications made by a database application into a corresponding database as well as on a blockchain for global consensus confirmation. This is done without changing the existing application architecture and with minimal code changes to the existing application. Records in the database requiring synchronization with the blockchain are subjected to consensuses voting, and unauthorized database changes are rolled back, thereby granting immutability and non-repudiation characteristics to a traditional database application. Records in databases are thus made globally consistent. An existing database application can be deployed on a blockchain without significantly modifying the code. Multiple applications can synchronize data through a common blockchain, which greatly simplifies building blockchain applications.
Patent CA-3122635-A1 (CA)
Title: Panel system for truck box
Inventor: SAVOIE LUC
IPC: B60P7/06
Filed: 2021-06-17
Abstract: A panel system attached to a truck box is provided. The system has a pair of side panels attached to the truck box and moveable between an extended position above the truck box and a stowed position within the truck box. The system also has a rear panel associated with the pair of side panels. The rear panel is configured to retain the pair of side panels in the extended position. The pair of side panels is configured to retain the rear panel in the stowed position. The system may carry more cargo and be easy to install and use.
Patent CA-3124730-A1 (CA)
Title: Small rna medicament for prevention and treatment of inflammation-related diseases and combinations thereof
Inventor: JIANG CHENGYU
IPC: A61P35/00
Filed: 2018-12-25
Abstract: Provided is a small RNA, a composition comprising the small RNA, a method for using same and use of same. The small RNA or composition can inhibit the ability of any one or more of pathways or genes listed in Table 3, or decrease or down regulate the expression level of IL-1 beta, IL-6, and/or TNF-alpha in vivo or in vitro, or treat or prevent IL-1 beta, IL-6, and/or TNF-alpha related diseases and/or increase cell viability in a subject.
Patent CA-3126704-A1 (CA)
Inventor: PHAM SON MINH
IPC: C07D401/12
Filed: 2020-01-17
Abstract: L'invention concerne des composés d'aminopyrazine utilisés comme modulateurs d'un récepteur d'adénosine. Ces composés peuvent être utilisés en tant qu'agents thérapeutiques pour le traitement de maladies médiées par une voie de signalisation des récepteurs couplés aux protéines G et peuvent trouver une application particulière en oncologie.
Patent CA-3127347-A1 (CA)
Title: Floor-crossmember combination
Inventor: MCWILLIAMS CLIFFORD O
IPC: B62D25/20
Filed: 2021-08-10
Abstract: A floor-crossmember combination to be used in forming a dump trailer floor without the use of floor panels. Each floor-crossmember combination may have at least one elongate arm tenninating in a projection and a corresponding slot, allowing adjacent floor-crossmember combinations to be connected together via the projection of one and slot of the other, then welded together.
Patent CA-3129120-A1 (CA)
Inventor: BUSSKAMP VOLKER
IPC: C12N5/0793
Filed: 2020-03-02
Abstract: L'invention concerne un procédé de production de cellules photoréceptrices induites à partir d'une cellule initiale, le procédé comprenant la fourniture d'un ou de plusieurs facteurs de transcription (TF) comprenant au moins GON4L à la cellule initiale. Dans des modes de réalisation préférés de l'invention, la cellule initiale est une cellule souche pluripotente induite (iPSC) humaine. Dans d'autres modes de réalisation, Le procédé consiste à fournir les TF OTX2 et/ou NEUROD1 à la cellule initiale. L'invention concerne en outre les cellules produites et pouvant être obtenues par le procédé de l'invention, l'utilisation de ces cellules en tant que médicament dans le traitement de la rétinopathie, des vecteurs pour induire les cellules photoréceptrices de la présente invention et des combinaisons de facteurs de transcription destinés à cette utilisation.
Patent CA-3129127-A1 (CA)
Title: Applicator for microneedle patch
Inventor: BEE MARKUS
IPC: A61M37/00
Filed: 2020-02-19
Abstract: The invention relates to an applicator comprising a handle piece and a pressing body for a microneedle patch, which pressing body is connected to the handle piece. The invention also relates to a unit comprising an applicator of this type and comprising a microneedle patch having a multiplicity of microneedles. The pressing body is mounted for movement relative to the handle piece in a sliding joint or in a pivot joint at least between an idle position and a usage position by means of external operating forces and an internal restoring device. The pressing body has a pressing surface which is spaced apart from the pivot joint or sliding joint. In the idle position, the pressing body is not loaded by external operating forces, and the restoring device has the lowest internal energy. Furthermore, the pressing body can be moved relative to the handle piece toward the usage position by means of external operating forces acting on the pressing surface, the internal energy of the restoring device thus being increased. The present invention enables the microneedles to be pressed in substantially uniformly.
Patent CA-3138172-A1 (CA)
Title: A method of performing diffusion weighted magnetic resonance measurements
Inventor: TEH IRVIN
IPC: G01R33/563
Filed: 2020-04-24
Abstract: According to a first aspect of the present inventive concept, there is provided a method for performing a diffusion weighted magnetic resonance measurement on a sample, the method comprising: operating a magnetic resonance scanner to apply a diffusion encoding sequence to the sample; and operating the magnetic resonance scanner to acquire from the sample one or more echo signals; wherein the diffusion encoding sequence comprises a diffusion encoding time-dependent magnetic field gradient g(t) with non-zero components gl(t) along at least two orthogonal directions y and z, and a b- tensor having at least two non-zero eigenvalues, the magnetic field gradient comprising a first and subsequent second encoding block, wherein an n-th order gradient moment magnitude along direction l ? (y,z) is given by |Mnl(t)| = |?0 t gl(t')t 'n dt'|, and the first encoding block is adapted to yield, at an end of the first encoding block: along said direction y, |M ny (t)| = Tn for each 0 = n = m, where T n is a predetermined n-th order threshold, and along said direction z, |Mnz(t)| < Tn for each 0 = n = m - 1 and |Mnz(t)| > Tn for n = m; and the second encoding block is adapted to yield, at an end of the second encoding block: along each one of said directions l ? (y,z): |Mnt(t)| = Tn for each 0 = n = m, wherein m is an integer order equal to or greater than 1.
Patent CA-3140600-A1 (CA)
Inventor: DUROCHER DANIEL
IPC: A61P35/00
Filed: 2021-11-16
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR  deficiency.
Patent CA-3144409-A1 (CA)
Title: Apparatus for suspensing objects on a wall
Inventor: MALOTT DALE G
IPC: A47G1/16
Filed: 2021-12-29
Abstract: An apparatus for supporting an object on a wall includes a wall member including a rear side defining a wall mount plane to be held against a wall surface and a recess defined at least in part by a front wall portion. A frame member includes a frame mount section and an arm extending downward from the frame mount section for positioning down into the recess of the wall member for support. The front wall portion and the arm are configured such that an interaction of the arm and a rear surface of the front wall portion during a downward movement of the arm into the recess, while the frame mount section is spaced away from the wall surface, will cause at least one of the front wall portion or the arm to move.
Patent CA-3144468-A1 (CA)
Inventor: BAO XIAOYAN ROBERT
IPC: C12Q1/6869
Filed: 2020-08-26
Abstract: L'invention concerne des méthodes permettant d'identifier les effets, notamment un effet cible, de la modification génomique de cellules primaires. Ces méthodes sont réalisées avec une grande précision appropriée pour valider des approches d'ingénierie des lymphocytes T thérapeutiques.
Patent CA-3146205-A1 (CA)
Inventor: JANSSON LISELOTTE
IPC: C07K14/74
Filed: 2020-07-07
Abstract: The invention relates to methods for identifying tolerogenic peptides. The invention also relates to products used in and produced by such methods. The invention also relates to the use of such tolerogenic peptides in the treatment of disease.
Patent CA-3149472-A1 (CA)
Inventor: BREWER ERIK
IPC: A61J1/14
Filed: 2020-08-26
Abstract: The present invention relates to compositions and methods to provide continuous and controlled release of therapeutic agent(s) during a procedure such as an interventional vascular procedure, e.g., to reduce acute and chronic complications and improve outcomes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Patent CA-3150529-A1 (CA)
Title: Fuel grate for a grill
Inventor: YEKUTIELY SHAVIT
IPC: A47J37/07
Filed: 2020-09-10
Abstract: A fuel grate for a grill is disclosed. The fuel grate may include: a solid fuel support grate, configured to fit into an internal cavity of the grill; and at least one fuel ignition surface, configured to be placed at a predetermined distance from the solid fuel support grate in the internal cavity of the grill, wherein the distance is determined as to allow placing combustible fire starter in an amount sufficient for igniting a solid fuel.
Patent CA-3152898-A1 (CA)
Title: Enhanced polymer properties for coating and/or film
Inventor: BENADDI HAMID
IPC: C08L3/02
Filed: 2022-03-17
Abstract: There is provided a polyurethane and/or polyacrylic coating and/or film that includes a polyurethane and/or polyacrylic layer; a biodegradation-inducing additive in the polyurethane and/or polyacrylic layer at a concentration of between 0.1 to 6 % by weight. This polyurethane and/or polyacrylic coating and/or film is biodegradable.
Patent CA-3152944-A1 (CA)
Inventor: HSU HAILING
IPC: A61K47/68
Filed: 2020-09-02
Abstract: This invention provides compositions comprising a protein and an absorption enhancer, methods for treating inflammatory disorders, such as irritable bowel disease (IBD) comprising administering same, and methods for oral, intra-rectal, or other gut-related administration of a protein with an enzymatic activity, comprising orally, intra-rectally, or other gut-related administering same.
Patent CA-3153319-A1 (CA)
Title: Methods, mediums, and systems for testing fiber optic telecommunication systems
Inventor: PATTERSON WILLIAM W
IPC: H04B10/07
Filed: 2022-03-24
Abstract: This application describes techniques for testing fiber optic telecommunication systems, such as undersea fiber optic cable systems. Testing terminals may be deployed at a location of terminating equipment for a fiber optic cable. The testing terminals may be operated remotely. The testing terminals may be configured to programmatically test the cable by loading one or more tests and automatically configure the cable's transmitters and receivers based on predetermined loading schemes selected based on the tests to be performed. The testing terminals may iterate over channels and fiber pairs of the cable and may use back-to-back tests to remove artifacts from test results. Using the described techniques, a cable's channels and fiber pairs can be fully characterized in the amount of time afforded for a typical testing schedule, which was not generally possible using conventional testing.
Patent CA-3154389-A1 (CA)
Inventor: DANIYAN ANTHONY
IPC: A61P35/00
Filed: 2020-09-11
Abstract: La présente invention porte sur des récepteurs de reconnaissance d'antigène qui ciblent spécifiquement CD371 et des cellules comprenant de tels récepteurs de reconnaissance d'antigène ciblant CD371. La présente invention porte en outre sur des utilisations des récepteurs de reconnaissance d'antigène ciblant CD371 pour un traitement. La présente invention porte sur des méthodes et des compositions pour des immunothérapies. Elle concerne des récepteurs de reconnaissance d'antigène (par exemple, des récepteurs antigéniques chimériques (CAR)) ou des récepteurs des lymphocytes T (TCR)) qui ciblent spécifiquement CD371, des cellules comprenant de tels récepteurs, et des méthodes d'utilisation de telles cellules pour des traitements.
Patent CA-3155419-A1 (CA)
Inventor: JACOB CHRISTOPHER
IPC: C12Q1/68
Filed: 2020-09-23
Abstract: L'invention concerne des procédés, des compositions et des kits pour la détermination précoce du sexe d'un foetus. L'invention concerne également des procédés, des compositions et des kits pour détecter des acides nucléiques foetaux dans des échantillons biologiques (par exemple de l'ADN foetal acellulaire).
Patent CA-3156470-A1 (CA)
Inventor: HALL STEPHEN
IPC: A41H1/00
Filed: 2022-04-25
Abstract: A system and method for the identification of standard human body sizes, which can be shared with others for use in predicting garment sizes. A database of human body size code records is created, each having an alphanumeric code assigned thereto.  Each size code record corresponds to a plurality of anthropometric data clusters signifying individual combinations of human weight, height and shape dimensions. A  software component will use available anthropometric data to create the data clusters and associate them with the size code records, and to subsequently match individual users to size code records based upon provided anthropometric data related to their body. Users upon registration can be assigned to cohorts of similar sized individuals, for networking, communication and marketing purposes, and users associated with the same size code record or the same size cohort can enjoy predictable garment sizing and properly targeted communications based upon their body size and compatibility with particular gamients offered for sale.
Patent CA-3160663-A1 (CA)
Inventor: DUMONT MAXIME
IPC: C25D11/02
Filed: 2020-12-09
Abstract: A process for the making of metallic product with biocidal properties is disclosed, and first comprises anodizing a product having at least one metallic surface (e.g. aluminum, steel) using a controlled current density to form pores on the surfaces with controlled spatial density and depth. The process also comprises contacting the anodized metallic surfaces with a first biocidal solution before sealing the pores. Preferably, the metallic surfaces can be contacted again with the first biocidal solution after the sealing step. A method for reactivating biocidal properties of the metallic products is also disclosed, and comprises contacting again the biocidal product with a second biocidal solution. Preferably, the second solution is less concentrated than the first solution for safety sake. The invention provides a simpler, quicker, cheaper and improved process for treating or reactivating the metallic surfaces in order to obtain a metallic product having superior and enduring biocidal properties.
Patent CA-3161319-A1 (CA)
Inventor: LEVITSKY VICTOR
IPC: C07K14/47
Filed: 2020-12-11
Abstract: The present invention relates to a method of producing recombinant binding proteins with binding specificity for a peptide-MHC (pMHC) complex. The invention also relates to recombinant binding proteins comprising one, two or more designed repeat domain(s), preferably designed ankyrin repeat domain(s), with binding specificity for a pMHC complex, and to such binding proteins which further comprise a binding agent having binding specificity for a protein expressed on the surface of an immune cell, preferably a T-cell. In addition, the invention relates to nucleic acids encoding such binding proteins or repeat domains, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, including cancer, infectious diseases and autoimmune diseases.
Patent CA-3161445-A1 (CA)
Inventor: RUSNAK RYAN
IPC: G06Q30/00
Filed: 2020-11-12
Abstract: Disclosed herein are system, method, and computer program product embodiments for selecting a particular eligible transporter for transporting a first good for a first job. An embodiment operates by receiving a request for transporting the good from a pickup location to a delivery location. Thereafter, eligible transporters for transporting the good from the pickup location to a first intermediate location or the delivery location (option one), or from the first intermediate location to a second intermediate location or the delivery location (option two), are identifier. Subsequently, for each eligible transporter, an estimated completion time (ECT) for the transporting of the first good is derived. Based on the ECT for each eligible transporter, a request to transport the good is sent to one of the eligible transporters.
Patent CA-3162362-A1 (CA)
Inventor: NOVAK PETER
IPC: A61P3/10
Filed: 2019-12-20
Abstract: L'invention concerne un procédé de prévention ou de traitement du diabète de type 2, comprenant l'administration d'une quantité thérapeutiquement efficace de zinc enrichi en 64Zn.
Patent CA-3163754-A1 (CA)
Title: Electrical assembly having a heat sink that is unitarily and integrally formed with a lead of a power semiconductor
Inventor: DOWNS JAMES P
IPC: H01L23/367
Filed: 2022-06-17
Abstract: An electrical assembly that includes a semiconductor die, a heat sink and a case. The semiconductor die includes a power semiconductor device with a plurality of terminals, and a plurality of electrically conductive leads. Each of the electrically conductive leads is electrically coupled to an associated one of the terminals on the power semiconductor device. The heat sink has a base, a mount, and a plurality of fins. The mount extends from a first side of the base and is coupled to the semiconductor die. The fins are fixedly coupled to the base and extend from a second side of the base that is opposite the first side of the base. The case is formed of a first electrically insulating material. A first one of the leads is integrally and unitarily formed with the mount.