Patent SG-11201804148T-A (SG)
Title: Rsv f protein mutants
Inventor: CHE YE
IPC: A61K39/12
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101101110111010111101111101111011111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/109629 Al 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: Garnerville, NY 10932 (US). SONG, Xi; 27 Giovanni A61K 39/155 (2006.01) C07K 14/005 (2006.01) Drive, Waterford, CT 06385 (US). SWANSON, Kena A61K 39/12 (2006.01) Anne; 121 East George Avenue, Pearl River, NY 10965 (US). KODALI, Srinivas; 35 Matrick Court, Hillsbor- (21) International Application Number: ough, NJ 08844 (US). XU, Xin; 607 Glasmere Road, Mah- PCT/IB2016/057502 wah, NJ 07430 (US). EFFEREN, KariAnn Sweeney; 43 (22) International Filing Date: Pellom Place, Stamford, CT 06905 (US). CAI, Ping; One 9 December 2016 (09.12.2016) Christie Drive, New City, NY 10956 (US). TOMPKINS, (25) Filing Language: English Kristin Rachael; 6 Morris Road, Garrison, NY 10524 (US). NUNEZ, Lorna Del Pilar; 198 North State Road, (26) Publication Language: English Briarcliff Manor, NY 10510 (US). (30) Priority Data: (74) Agent: WALDRON, Roy F.; PFIZER INC., 235 East 62/387,270 23 December 2015 (23.12.2015) US 42nd Street, MS 235/9/S20, New York, NY 10017 (US). 62/421,184 11 November 2016 (11.11.2016) US (81) Designated States (unless otherwise indicated, for every (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, kind of national protection available): AE, AG, AL, AM, New York, NY 10017 (US). AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, — (72) Inventors: CHE, Ye; 166 Ledgewood Road, #308, Gro- DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, ton, CT 06340 (US). DORMITZER, Philip Ralph; 10 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, Cobblers Lane, Armonk, NY 10504 (US). GRIBENKO, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, Alexey Vyacheslavovich; 23 Hansen Avenue, New City, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, — NY 10956 (US). HANDKE, Luke David; 144 North NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, Broadway, Nyack, NY 10960 (US). PRASAD, Avvari RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, Krishna; 105 Worsham Drive, Chapel Hill, NC 27516 TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (US). QIU, Xiayang; 138 Long Wharf Drive, Mystic, CT ZA, ZM, ZW. 06355 (US). RUPPEN, Mark Edward; 6 Lea Court, [Continued on next page] — = = Title: RSV F PROTEIN MUTANTS (54) = = FIG. = = MELLILKANAITTILTAVITCFASGONITEEFYQSTCSAVSKGYLSALRIGWYTSVITIE = = LSNIKENKONGTDAKVKLIKQELDKYKNAVTELOLLMOSTPATNNRARRELPRFMN = = YTLNNAKKINVILSKKRKRRELGFLLGVGSAIASGVAVSKVLHLEGEVNK KSALLS INKAWSLSNGVSVLTSKVLDLKNYIDKOLLPIVNKOSCSISNIETVIEFOOKNNRLLE = ITREFSVNAGVTTPVSTYMLINSEI [ SLINDMPITNDOKKLMSNNVOIVROOSYSEMS IIKEEVLAYVVOLPLYGVIDTPDVKLFITSPLCTINTKEGSNICLTRIDRGWYCDNAG 1-1 SVSFFPQAEICKVOSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVS SSVITSLGANSCYGKIKOTASNKNRG 1KTFSNGCDYVSNKGVDTVSVGNTLYYVN 0\ V::+ el KOECKSLYVKGEN I NFYDPLVFPSDEFDAS1SQVN EK1 N QS LAFI RKSDELLSA1 GGY 0\ 0 IPEAPRDGOAYVVDGEMLLSTFLGGLVPRGSHHHHHEIGNISHPOFEK 1-1 Elm 1-1 (57) : The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, N compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions. WO 2017/109629 Al MIDEDItitiMIRDEZHEDIONIEHOMMUDIMIE (84) Designated States (unless otherwise indicated, for every as to applicant's entitlement to apply for and be granted kind of regional protection available): ARIPO (BW, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, GH, a patent (Rule 4.170) SZ, RU, — as to the applicant's entitlement to claim the priority of DE, the earlier application (Rule 4.17(iii)) LT, Published: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). SE, GA, — with international search report (Art 21 ( 3 )) — before the expiration of the time limit for amending the Declarations under Rule 4.17: claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — as to the identity of the inventor (Rule 4.17(0) — with sequence listing part of description (Rule 5.2(a))