baber/WOPTO huggingface dataset:
Patent WO-2019183367-A1 (WO)
Inventor: TAYLOR ALEXANDER
IPC: C07D401/06
Filed: 2019-03-21
Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.
Patent WO-2019191151-A1 (WO)
Title: In vitro and in vivo intracellular delivery of sirna via self-assembled nanopieces
Inventor: CHEN QIAN
IPC: A61K31/519
Filed: 2019-03-26
Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Patent WO-2020214183-A1 (WO)
Inventor: REIDERMAN ARCADY
IPC: G01V3/32
Filed: 2019-04-19
Abstract: Methods, devices, and systems for tracking lateral motion of a nuclear magnetic resonance (NMR) tool are disclosed. In some embodiments, a phase shift for one or more spin-echo signals received by the NMR tool is detected during a velocity measurement sequence that corresponds to at least one formation measurement sequence. A lateral velocity of the NMR tool is determined based, at least in part, on the detected phase shift.
Patent WO-2019213423-A1 (WO)
Title: Tip assemblies, systems, and methods for fracturing a frame of a deployed prosthesis
Inventor: GENOVESE MATTHEW
IPC: A61F2/24
Filed: 2019-05-02
Abstract: A system for fracturing a frame of a deployed prosthesis with ultrasonic vibration includes a shaft (303), a tip assembly, an ultrasonic electric generator (307), and an ultrasonic transducer (309). The shaft includes a proximal portion and a distal portion. The tip assembly is coupled to the distal portion of the shaft. The tip assembly includes a cutting edge (315). The ultrasonic transducer is electrically coupled to the ultrasonic generator. Ultrasonic vibration generated by the ultrasonic transducer is translated to the tip assembly. The cutting edge of the tip assembly is configured to focus the vibration of the tip assembly onto a frame of a deployed prosthesis to fracture the frame of the prosthesis. The ultrasonic transducer may be coupled to the proximal portion or the distal portion of the shaft.
Patent WO-2019217562-A1 (WO)
Title: Aggregated image annotation
Inventor: IRSHAD HUMAYUN
IPC: G06F17/24
Filed: 2019-05-08
Abstract: Image annotation includes: accessing an image and a plurality of annotation data sets for the image, wherein the plurality of annotation data sets are made by a plurality of contributors, and the image has a plurality of original image channels; aggregating the plurality of annotation data sets to obtain an aggregated annotation data set for the image; and outputting the aggregated annotation data set. Aggregating the plurality of annotation data sets to obtain an aggregated annotation data set for the image includes: generating an additional image channel based at least in part on weight averages of confidence measures of the plurality of contributors; and applying an object detection model to at least a part of the plurality of original image channels and at least a part of the additional image channel to generate the aggregated annotation data set.
Patent WO-2019217652-A1 (WO)
Title: Flexible light guide and heat sink for endoscopic systems
Inventor: MCLEAN EDWARD
IPC: G02B6/00
Filed: 2019-05-09
Abstract: A flexible electronic light guide (18) for an endoscope (10) that acts as a heat sink for the light emitting diode (LED). A flexible tube (126) within the light guide extends from the LED to shunt heat away from the LED. The flexible tube may be a solid metal tube that is perforated to be flexible. The flexible tube may also be a braided wire jacket and may enclose a series of metal balls that are in contact with each other. The flexible tube may also be made of a plurality of different metals. The flexible tube may also be a hollow tube and support an air or liquid cooling system or be packed with metal balls that can be as small as grains of sand. The flexible tube may also be a linkage formed from a series of metal components held in tight contact by a spring.
Patent WO-2019231879-A1 (WO)
Title: Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making
Inventor: POUDEL YAM B
IPC: A61K47/68
Filed: 2019-05-28
Abstract: Compounds represented by formula (I) can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.
Patent WO-2020096647-A1 (WO)
Inventor: MARINOV MARTIN CVETANOV
IPC: G06T17/00
Filed: 2019-05-28
Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures include, in at least one aspect, a fully automatic method of converting a generative design into an editable, watertight B-Rep by leveraging the generative solver input and representation to: (1) embed the exact input solid boundary surfaces where the design coincides with the input, (2) approximate everywhere else the design boundary with globally smooth, editable "organic" surfaces, and (3) join all surfaces to form a generative design output B-Rep.
Patent WO-2019240976-A1 (WO)
Title: Housing for mounting of components in head mounted display
Inventor: TOLENO BRIAN J
IPC: B29L31/34
Filed: 2019-06-04
Abstract: A housing, including mounting features for directly mounted components, is formed by curing carbon fiber reinforced polymer (CFRP) and a molding compound (MC) such as a sheet molding compound (SMC) or a bulk molding compound (BMC). SMC or BMC may be used depending on the implementation. This forms a housing with mounting features in a thermoset manner, in which the weight of a product such as a head mounted display (which incorporates the housing comprising the mounting features) is reduced, and any orientation issues or problems are significantly reduced.
Patent WO-2020006201-A1 (WO)
Title: Fastening aid, fastening system, connector and method for fastening a fastener
Inventor: MATHIAS LUKE MARCO
IPC: H01R13/622
Filed: 2019-06-27
Abstract: A fastening aid for screwing a fastener having a locknut by rotating the fastener around a rotation axis with a predetermined torque includes a sleeve element being attachable around the locknut along the rotation axis, an engaging structure provided at an inner surface of the sleeve and configured to engage with the locknut when the sleeve is attached around the locknut, a clasp element for reversibly closing the sleeve element to a closed state for attaching the sleeve around the locknut, and for reversibly opening the sleeve element to an opened state for detaching the sleeve from the locknut. The fastening aid is configured to allow screwing of the fastener around the rotation axis when exposed to a torque smaller than or equal to the predetermined torque and to prevent screwing the fastener around the rotation axis when the predetermined torque is exceeded.
Patent WO-2020014004-A1 (WO)
Title: Digital pixel imager with dual bloom storage capacitors
Inventor: CANTRELL JOSHUA J
IPC: H04N5/3745
Filed: 2019-06-28
Abstract: An integration capacitor network for connection to a photo-current source includes: an input; a first path connected between the input and a reset voltage, the first path including a first integration capacitor and a first cascode transistor, the first cascode transistor coupled between the input and the first integration capacitor; and a second path connected between the input and the reset voltage, the second path including a second integration capacitor and a second cascode transistor, the second cascode transistor coupled between the input and the second integration capacitor. Gates of the first and second cascode transistors are connected to a reference voltage and charge is accumulated on the first integration capacitor until a voltage on the first integration capacitor exceeds the reference voltage and then charge is accumulated on the second integration capacitor.
Patent WO-2020047053-A1 (WO)
Inventor: WINTERMANTEL WILLIAM M
IPC: C12N15/113
Filed: 2019-08-28
Abstract: The present disclosure provides compositions and methods utilizing double strand ribonucleic acid (dsRNA) to control insects, including whiteflies. More particularly, the present invention relates to several specific synthetic dsRNAs that induce RNA interference (RNAi) in the target insects and methods of delivering the dsRNAs to them, such as allowing feeding on plants treated with, or transgenically expressing, the dsRNAs.
Patent WO-2020047165-A1 (WO)
Inventor: JENSEN MICHAEL C
IPC: C12N15/85
Filed: 2019-08-28
Abstract: Some embodiments provided herein relate to gene delivery systems and methods using a single plasmid that carries a self-inactivating transposase gene and a corresponding transposon. Some embodiments include nucleic acids having certain sequences, vector including such nucleic acids, and compositions including the vectors.
Patent WO-2020056150-A1 (WO)
Title: Vaporizer including positive temperature coefficient of resistivity (ptcr) heating element
Inventor: ALSTON WILLIAM
IPC: A24F47/00
Filed: 2019-09-12
Abstract: An apparatus includes a housing including a power source; a reservoir including an inlet, an outlet, and configured to contain vaporizable material and couple to the housing; and a PTCR heating element configured to electrically couple to the power source and heat the vaporizable material to form an aerosol. The PTCR heating element includes an electrical resistivity that varies based on temperature. The electrical resistivity includes an electrical resistivity transition zone including an increase in electrical resistivity over a temperature range such that, when the PTCR heating element is heated to a first temperature within the transition zone, current flow from the power source is reduced to a level that limits further temperature increases of the PTCR heating element. Related apparatus, systems, techniques, and articles are also described.
Patent WO-2020072375-A1 (WO)
Inventor: REILLY JOHN J
IPC: G06Q10/10
Filed: 2019-09-30
Abstract: Aspects of the disclosure provide for mechanisms data anonymization. A method of the disclosure includes: receiving, by a processing device, a user input initiating anonymization of a first electronic document, wherein the first electronic document comprises at least one first data item relating to personally identifiable information and at least one second data item not related to the personally identifiable information; in response to receiving the user input, generating a second electronic document, wherein the second electronic document comprises a digital fingerprint of the first electronic document and the at least one second data item; and transmitting, to a server, the second electronic document as an anonymized version of the first electronic document.
Patent WO-2020076709-A1 (WO)
Inventor: KALB FRANK
IPC: E21B47/18
Filed: 2019-10-07
Abstract: An mterventionless system and method: of detecting a downhole activation device are provided. The system includes a first detector disposed downhole in a fluid pathway and;a second detector disposed downhole of the first detector in the fluid pathway. In one exemplary embodiment, the detectors include a pair of ultrasonic transducers that generate signals indicative of fluid pathway flow. Differences in the signals between the detectors are indicative of the presence of the downhole activation device within the fluid pathway. The system also includes a deployment port disposed above the second detector from which the downhole activation device may be deployed into the fluid pathway.
Patent WO-2020087027-A1 (WO)
Inventor: VARDOULIS ORESTIS
IPC: A61B5/00
Filed: 2019-10-25
Abstract: Various embodiments are directed to sensor apparatuses and methods thereof. An example sensor apparatus includes a plurality of capacitors and sensor circuitry. The plurality of capacitors including a first substrate having a plurality of first electrodes, a second substrate having a second electrode, and a dielectric material, and with the plurality of first electrodes and the second electrode being separated by the dielectric material. The plurality of first electrodes are aligned with respect to the second electrode such that each of plurality of first electrodes form one of the plurality of capacitors with the second electrode. The sensor circuitry is coupled to the plurality of capacitors to differentiate between normal and shear forces applied to apparatus based on a pattern of impedance responses of each of the plurality of capacitors formed by the second electrode and the plurality of first electrodes.
Patent WO-2020097097-A1 (WO)
Title: Reduce data traffic between cache and memory via data access of variable sizes
Inventor: WALLACH STEVEN JEFFREY
IPC: G06F12/0871
Filed: 2019-11-05
Abstract: A computing system, method and apparatus to cache a portion of a data block. A processor can access data using memory addresses in an address space. A first memory can store a block of data at a block of contiguous addresses in the space of memory address. A second memory can cache a first portion of the block of data identified by an item selection vector. For example, response to a request to cache the block of data stored in the first memory, the computing system can communicate the first portion of the block of data from the first memory to the second memory according to the item selection vector without accessing a second portion of the block of data. Thus, different data blocks in the first memory of a same size can be each cached in different cache blocks of different sizes in the second memory.
Patent WO-2020236210-A1 (WO)
Inventor: SINGH RISHI
IPC: H04B1/18
Filed: 2019-11-05
Abstract: A receiver can include a first set of one or more amplifier stages configured to amplify input signals in a plurality of communication bands. The receiver can further include a second and third set of one or more amplifier stages. The second set of one or more amplifier stages can be configured to selectively receive the input signals in the plurality of communication bands amplified by the first set of one or more amplifier stages and to amplify one or more input signals in a first one of the plurality of communication bands. Alternatively, the third set of one or more amplifier stages can be configured to selectively receive the input signals in the plurality of communication bands amplified by the first set of one or more amplifier stages and to amplify one or more input signals in a second one of the plurality of communication bands. A first set of one or more mixers can be configured to receive the Input signals in the first communication band amplified by the second set of one or more amplifier stages, to.receive one or more local oscillator signals for the first communication band, and to generate a baseband signal from a frequency difference of the signal of the first communication band and the one or more local oscillator signals for the first communication band. A second set of one or more.: mixers can be configured to receive the input signal in the second communication band amplified by the third set of one or more amplifier stages, to receive one or more local oscillator signals for the second communication band, and to generate a baseband signal, of the second communication band.
Patent WO-2020117607-A1 (WO)
Title: Lubricity additive for transportation fuels
Inventor: KOSEOGLU OMER
IPC: C10L1/24
Filed: 2019-11-28
Abstract: Oxidized disulfide oil (ODSO) compounds, derived from by-product disulfide oil (DSO) compounds from the MEROX process, are effective as lubricity additives for transportation fuels. Significant increases in lubricity of ultra-low sulfur fuels as measured by the WSD test were observed with addition of ODSO compounds in the range of from 0.1 ppmw to 10 ppmw. This use of ODSO compounds as lubricity additives converts an otherwise DSO waste oil product into a valuable commodity that has utility in improving lubricity properties of transportation fuels.
Patent WO-2020149979-A1 (WO)
Inventor: ZHANG LONG
IPC: A01H9/00
Filed: 2019-12-18
Abstract: A genetically modified houseplant capable of reducing levels of volatile organic carcinogenic compounds, such as formaldehyde, benzene, and chloroform, in the indoor air in urban homes of developed countries is disclosed. The plant expresses a detoxifying transgene, mammalian cytochrome P450 2e, and has shown sufficient detoxifying activity against benzene and chloroform. Air purifying biofilters utilizing the plants and methods of their use are also disclosed.
Patent WO-2020160080-A1 (WO)
Title: Oil/surfactant mixtures for self-emulsification
Inventor: LODAYA RUSHIT
IPC: A61K39/39
Filed: 2020-01-29
Abstract: Methods of manufacturing squalene and alpha-tocopherol-containing oil-in-water emulsions having small oil droplet particle sizes. Such emulsions being of use as vaccine adjuvants.
Patent WO-2020168016-A1 (WO)
Inventor: PERERA JASON
IPC: C12Q1/68
Filed: 2020-02-12
Abstract: L'invention concerne des méthodes de détection de la perte d'hétérozygotie de l'antigène leucocytaire humain (HLA) chez un sujet à l'aide d'une analyse de données de séquençage de nouvelle génération (NGS). Ces méthodes comprennent les étapes consistant à : aligner des données de NGS et à identifier des lectures non mappées et mappées ; mettre à jour des données de référence, et fournir au moins une lecture de séquence à un processus de typage de HLA pour identifier des allèles de HLA candidats et fournir des données de type de HLA à un processus de modélisation de perte d'hétérozygotie (LOH) pour déterminer un état de LOH pour chaque allèle de HLA. Un rapport peut être généré des états de LOH pour chaque allèle de HLA.
Patent WO-2020168097-A1 (WO)
Inventor: SWENSON LOREN J
IPC: G06N10/00
Filed: 2020-02-13
Abstract: L'invention concerne un circuit qui peut comprendre un couplage galvanique d'un coupleur à un bit quantique par un segment de matériau d'inductance cinétique. Le circuit peut comprendre un coupleur d'inductance cinétique galvanique ayant de multiples enroulements. Le circuit peut comprendre un coupleur partiellement galvanique ayant de multiples enroulements. Le coupleur partiellement galvanique peut comprendre un couplage magnétique et un couplage galvanique. Le circuit peut comprendre un coupleur asymétrique partiellement galvanique ayant un couplage galvanique et un premier couplage magnétique à un bit quantique et un second couplage magnétique à un second bit quantique. Le circuit peut comprendre un bit quantique à inductance cinétique compact ayant une boucle de corps de bit quantique comprenant un matériau à inductance cinétique. Un circuit intégré multicouche comprenant une couche d'inductance cinétique peut former un couplage d'inductance cinétique galvanique. Un circuit intégré multicouche comprenant une couche d'inductance cinétique peut former au moins une partie d'une boucle corporelle à bits quantiques à inductance cinétique compacte.
Patent WO-2020172089-A1 (WO)
Inventor: LUDWIG HARTMUT
IPC: G05B19/418
Filed: 2020-02-17
Abstract: Des approches actuelles pour intégrer des écosystèmes industriels, par exemple l'intégration de fonctions d'automatisation chez différents vendeurs, manquent d'efficacité et de capacités. Par exemple, des intégrateurs de système sont souvent nécessaires pour développer un logiciel spécial qui fonctionne comme un proxy ou un adaptateur entre différents systèmes. Dans de tels cas, le proxy ou l'adaptateur est souvent spécifique à un ensemble particulier d'équipements ou de vendeurs, et peut limiter la réutilisation, parmi d'autres inconvénients techniques. Des modes de réalisation décrits dans la présente invention pallient un ou plusieurs des inconvénients ou problèmes techniques rapportés dans l'invention en proposant des procédés, des systèmes et des appareils pour générer automatiquement des interfaces, par exemple un code de liaison, qui permet une interopérabilité entre différents écosystèmes dans des systèmes industriels automatisés.
Patent WO-2020172495-A1 (WO)
Inventor: TEGGATZ ROSS
IPC: G01N27/416
Filed: 2020-02-21
Abstract: The present invention includes a device and method comprising: one or more wells on a substrate onto which one or more molecules of interest (MOI) binding reagents are attached, wherein each of the one or more MOI binding reagents is within a molecular proximity of one or more detectable signal molecules, wherein each of the one or more detectable signal molecules comprise one or more signal molecules that are releasable in the presence of the MOI by one or more enzymes and the signal is detected by an electronic detection system.
Patent WO-2021167619-A1 (WO)
Title: Robotic surgical system and method for providing a stadium view with arm set-up guidance
Inventor: JOHNSON ERIC
IPC: A61B34/20
Filed: 2020-02-21
Abstract: A robotic surgical system and method for providing a stadium view with arm set-up guidance is provided. In one embodiment, a robotic surgical system comprises a plurality of robotic arms, a display device, and a processor. The processor is configured to render, on the display device, a graphical representation of the plurality of robotic arms in their current positions, as well as user-guidance information on how to move the plurality of robotic arms to a different position. Other embodiments are provided.
Patent WO-2020180883-A1 (WO)
Inventor: LI JUNYI
IPC: H04L1/00
Filed: 2020-03-03
Abstract: Methods, systems, and devices for wireless communications are described. A wireless device (e.g., a user equipment and/or base station) (405) may operate in a first mode in a wireless network over a radio frequency spectrum band (415). The wireless device (405) may receive a signal indicating that a value of the radio frequency spectrum band has satisfied a threshold value (420). The wireless device may switch, based at least in part on the signal indicating that the value has satisfied the threshold value, from the first mode to a second mode for wireless communications in the wireless network (425), wherein a first length of a first synchronization signal block associated with the first mode is shorter than a second length of a second synchronization signal block associated with the second mode.
Patent WO-2020185980-A1 (WO)
Title: Smooth transition between adaptive cruise control and cruise control using virtual vehicle
Inventor: TANG YIFAN
IPC: B60W30/165
Filed: 2020-03-12
Abstract: An autonomous vehicle with adaptable cruise control in which a virtual vehicle object is generated to pace the autonomous vehicle for a smooth acceleration when transitioning between an ACC mode and a CC mode. An acceleration profile sets a virtual vehicle object acceleration as a function of a speed difference between the current road speed limit and the current autonomous vehicle speed, and the current autonomous vehicle acceleration. The perception data may be generated for the virtual vehicle object to simulate the existence of the virtual vehicle object on the road traveled by the autonomous vehicle. The generated perception data and acceleration data are provided to an ACC module to control the acceleration of the autonomous vehicle. The acceleration profile of the virtual vehicle object is tunable.