baber/WOPTO huggingface dataset:
Patent JP-2023172248-A (JP)
Title: スタビライザユニット
IPC: B60G21/055
Filed: 2022-05-23
Abstract: 【課題】スタビライザユニットの構造によって搭載性を高くする技術を提供する。【解決手段】スタビライザユニットは、サスペンションメンバと、車幅方向に延びるスタビライザバーと、前記スタビライザバーを前記サスペンションメンバに取り付けるスタビライザ用マウント部材と、を備え、前記スタビライザバーは、前記スタビライザ用マウント部材に支持されている支持部分の延長上で、前記サスペンションメンバに車両走行用のモータユニットを固定するモータ用マウント部材と重なっており、前記支持部分よりも前記車幅方向の内側において、車両後方に曲げられて、前記モータ用マウント部材の後方を通過してもよい。【選択図】図２
Patent JP-2023173171-A (JP)
Title: 画像形成装置、画像形成方法、制御装置、及びプログラム
IPC: B41J2/17
Filed: 2022-05-25
Abstract: 【課題】吐出受けの交換頻度の低下を図る。【解決手段】画像形成装置２００は、複数の媒体に液体を吐出するノズル部と、ノズル部から吐出された液体を受ける吐出受けと、印刷ジョブによる画像形成に寄与しない液体をノズル部から吐出するようにノズル部の動作を制御する制御部と、を備え、複数の媒体は、印刷ジョブによる画像が形成される第１媒体と、印刷ジョブによる画像が形成されない第２媒体と、を含み、制御部は、第２媒体に対して、ノズル部から液体を吐出するようにノズル部の動作を制御する。【選択図】図５
Patent JP-2022116191-A (JP)
Title: Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization
IPC: A61K9/127
Filed: 2022-05-26
Abstract: PROBLEM TO BE SOLVED: To provide a method for treating ocular indications involving abnormal neovascularization. 
     SOLUTION: There is provided a method comprising administering to an eye of a subject an effective amount of nintedanib or a pharmaceutically acceptable salt thereof in a form of topical eye drop or an implant. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023176869-A (JP)
Title: 筒状カラーの圧造成形方法及び圧造成形装置
IPC: B21J5/12
Filed: 2022-06-01
Abstract: 【課題】割型を不要にして円筒状カラーの成形工程の簡素化及び低廉価を図りつつ、圧造成形品としての見栄えや品質の向上を図ることができる円筒状カラーの圧造成形方法及び圧造成形装置を提供する。 
【解決手段】円柱形状のブランクの軸線方向両端面を矯正し、その矯正したブランクの両端面にそれぞれ一端側及び他端側ガイド凹部２２，３２を開口縁が面取りされつつ形成してから、ブランクの他端側ガイド凹部３２から一端側ガイド凹部２２まで貫通する貫通孔Ｏを圧造成形する。その後、ブランクＢ４を軸線ｍ方向両側から圧造成形すると、その両端面での各ガイド凹部２２，３２の開口縁の面取り部分Ｏ１，Ｏ２による表面積の減少によりブランクＢ４の両端部を第５ダイスＤ５２の内周面との隙間Ｓに向かって半径方向外方へ滑らせながら拡径するように変形させ、両端部の外径部分にそれぞれ拡径部Ｋ，Ｋを有する円筒状カラーＣを得る。 
【選択図】図１２
Patent JP-2022116303-A (JP)
Title: Methods for purifying steviol glycosides and uses of the same
IPC: A23L27/30
Filed: 2022-06-06
Abstract: PROBLEM TO BE SOLVED: To provide: methods for purifying steviol glycosides, including Rebaudioside X (Reb X); sweetener and sweetened compositions containing Reb X; beverages containing the compositions; and methods of improving a flavor and/or a temporal profile of sweetenable compositions. 
     SOLUTION: A method for purifying Reb X comprises the steps of: a. passing a solution of steviol glycosides through a multi-column system including a plurality of columns packed with an adsorbent resin to provide at least one column having adsorbed steviol glycosides; and b. eluting fractions with a high Reb X content from the at least one column having adsorbed steviol glycosides to provide an eluted solution with the high Reb X content. 
     SELECTED DRAWING: Figure 19 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023181725-A (JP)
Title: 電池劣化判定システム、電池劣化判定装置及び電池劣化判定方法
IPC: G01R31/392
Filed: 2022-06-13
Abstract: 【課題】二次電池の劣化判定を迅速かつ効率的に行うことを課題とする。【解決手段】電池劣化判定システムは、複数のサンプリング時間の異なる充放電特性の電圧値を計測し、その計測値に基づいて図３に示した等価回路の等価回路定数を算出する。そして、時間によって変化するメインタンク回路の時定数を算出し、その時定数に基づいた等価回路モデルを作成し、二次電池２０の新品時の初期等価回路定数１３ｂと、所定期間使用した二次電池２０の等価回路定数１３ｄとを比較して、等価回路定数の変化が所定の閾値以内か否かにより二次電池２０の劣化を判定する。【選択図】図１
Patent JP-2022113855-A (JP)
Title: Use of adamts13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
IPC: A61P9/08
Filed: 2022-06-16
Abstract: PROBLEM TO BE SOLVED: To provide: compositions and methods for treating, ameliorating and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD); and compositions and methods for treating, ameliorating or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). 
     SOLUTION: The invention provides a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating and/or preventing the VOC, or for treating, ameliorating or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2024002643-A (JP)
Title: 画像形成装置
IPC: G03G15/00
Filed: 2022-06-24
Abstract: 【課題】画像形成装置で形成される画像における周期的な濃度ムラを抑制する。 
【解決手段】画像形成装置は、感光体、感光体を一様に帯電させる帯電器、帯電された感光体に静電潜像を形成する露光器、及び静電潜像を現像して感光体に画像を形成する現像器を含み、形成された画像の画像濃度を検知するためのテスト画像を読み取る。画像形成装置は、テスト画像を形成し、その検知結果に基づいて画像濃度の周期的な変動を検知し、検知した周期的な変動が低下するように画像形成条件を補正する。補正された画像形成条件によって前記画像形成手段に画像を形成させ（Ｓ１０３）、形成された画像を読み取り、その読取結果から前記画像濃度の周期的な変動を抑制するための候補信号を生成する（Ｓ１０９）。 
【選択図】  図１２
Patent JP-2024004311-A (JP)
Title: 弾性波デバイス
IPC: H03H9/25
Filed: 2022-06-28
Abstract: 【課題】弾性波デバイスにおいて、デバイスチップのパッケージ基板に対するシェア強度を低下させることなく、バンプを合理的に小型化できるようにする。【解決手段】パッケージ基板２の一面２ａにＩＤＴ電極７を含む機能素子を有する主面３ａを向き合わせて前記パッケージ基板２に実装されるデバイスチップ３と前記パッケージ基板２とを、前記機能素子を含む前記デバイスチップ３側の回路と前記パッケージ基板２側の回路とを電気的に接続させるバンプ４と、このバンプ４の近傍にあって前記パッケージ基板２の前記一面２ａと前記デバイスチップ３の前記主面３ａとの間に介在される接着層１０とからなる主固着部１１によって固着させてなる。【選択図】図１
Patent JP-2024005668-A (JP)
Title: 希土類磁石
IPC: H01F1/057
Filed: 2022-06-30
Abstract: 【課題】製造時の作業性に優れる高性能な希土類磁石を提供すること。【解決手段】希土類磁石は、Ｒ（ＲはＮｄを含む希土類元素を示す。）、Ｆｅ及びＢを含有するＲ－Ｆｅ－Ｂ系合金を熱間塑性加工した希土類磁石であって、前記希土類磁石は、Ｒ2Ｆｅ14Ｂ化合物を含む主相の組織を有し、磁化容易軸が前記主相の結晶粒の短軸方向に向いており、前記磁化容易軸方向における厚さ寸法が０．０７ｍｍ以上０．２ｍｍ以下であり、残留磁化の低下率が５％以下である（ここで、前記残留磁化の低下率（％）は、前記希土類磁石の前記厚さ寸法が０．５ｍｍのときの残留磁化を１００％とし、これに対して低下した割合である。）。【選択図】なし
Patent JP-2024010846-A (JP)
Title: 光ファイバの巻取り装置およびトルク制御ローラ
IPC: B65H59/10
Filed: 2022-07-13
Abstract: 【課題】所定のトルクで回転駆動されるローラの表面における光ファイバの滑りの発生を抑制し、光ファイバの断線を抑制する。【解決手段】光ファイバの巻取り装置は、光ファイバを巻き取る巻取りボビンと、所定のトルクで回転駆動されて、巻取りボビンへ搬送される光ファイバをガイドするローラと、を備えており、ローラは、本体部と、光ファイバが接する接触部とを有しており、接触部は、ゴムにより形成されており、本体部に着脱可能に取り付けられている。【選択図】図１
Patent JP-2022153464-A (JP)
Title: Melt modified material having high cellulose fiber content
IPC: C08B15/00
Filed: 2022-07-13
Abstract: PROBLEM TO BE SOLVED: To provide a cellulose fiber-containing preparation that is at least partially modified to contain dialcohol cellulose, and to provide a melt modification process for producing the same. 
     SOLUTION: Provided is a material, which is a cellulose fiber-containing material, and in which the cellulose fiber is at least partially modified to dialcohol cellulose, and the amount of modified cellulose fiber in the material is greater than 60 wt.%, and the degree of conversion of the at least partially modified cellulose to dialcohol cellulose is at least 10% and less than 70%, based on the total number of oxidizable C2-C3 bonds in the cellulose material; and the material is an extruded layer in a laminate for liquid packaging. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2024011684-A (JP)
Title: 遊技機
IPC: A63F7/02
Filed: 2022-07-15
Abstract: 【課題】装飾図柄を利用して遊技の趣向性を向上させることが可能な遊技機を提供すること。【解決手段】複数種の装飾図柄が変動を開始した後、当否抽選結果に応じた図柄組み合わせで変動が停止するまでの変動中演出が実行される遊技機であって、前記変動中演出のモードとして、前記図柄組み合わせが、Ｎ種の前記装飾図柄のうちから選択されて構成される第一モードと、前記第一モードよりも当否抽選結果が当たりとなる蓋然性が高いモードであって、前記図柄組み合わせが、Ｍ種の前記装飾図柄のうちから選択されて構成される第二モードと、が設けられていることを特徴とする遊技機。【選択図】図２２
Patent JP-2022137313-A (JP)
Title: Pen for allowing sensor controller for detecting the pen to receive transmission data transmitted via sensor electrode group
IPC: G06F3/03
Filed: 2022-07-25
Abstract: PROBLEM TO BE SOLVED: To provide a method for transmitting transmission data from a sensor controller to a pen, and to provide the pen. 
     SOLUTION: In a position detection system, a reception circuit 61 of a pen for receiving transmission data transmitted, via a sensor electrode group, by a sensor controller for detecting the pen includes: an analog circuit 71 including a nib electrode disposed near a nib, a differential circuit (a high-pass filter 80 and an amplification circuit 81) for detecting an edge of a signal guided by the nib electrode, and a ΔΣ modulation part 82 for performing comparison by using at least two pieces of reference potential corresponding to each polarity for an output signal of the differential circuit, and for performing feedback processing of the comparison result; and a digital circuit 72 for detecting transmission data by correlation operation between an output signal of the ΔΣ modulation part 82 and a known pattern. 
     SELECTED DRAWING: Figure 13 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2022161932-A (JP)
Title: Long lasting effect of new botulinum toxin formulation
IPC: A61K47/20
Filed: 2022-08-03
Abstract: PROBLEM TO BE SOLVED: To provide a botulinum toxin composition to treat a disease, disorder or condition in a patient in need thereof. 
     SOLUTION: The invention relates to a method for treating a patient using a therapeutically effective amount of an animal-protein-free botulinum toxin composition, where the animal-protein-free botulinum toxin composition exhibits a longer lasting effect in the patient compared to an animal-protein-containing botulinum toxin composition. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023035884-A (JP)
Title: Magnetic bearing device and vacuum pump
Inventor: ONO TAKAAKI
IPC: F04D19/04
Filed: 2022-08-05
Abstract: To provide a magnetic bearing device which is capable of recovering from an abnormal state of oscillation etc., with high operation efficiency and safely in a levitation system using a magnetic bearing, reduces erroneous detection of abnormality and improves reliability, and a vacuum pump.SOLUTION: A magnetic bearing device comprises: a magnetic bearing which floats and supports a rotation body in the air with a magnetic force; and a magnetic bearing controller which controls the magnetic bearing. The magnetic bearing device comprises: first abnormality detection means which detects abnormality of control by the magnetic bearing controller based on a predetermined first abnormality condition; control parameter correction means which corrects a control parameter of the magnetic bearing controller while continuing operation of the magnetic bearing device when abnormality of control is detected by the first abnormality detection means; second abnormality detection means which detects abnormality of control by the magnetic bearing controller based on a predetermined second abnormality condition with a greater degree of abnormality than the first abnormality condition; and stop means which stops operating the magnetic bearing device when abnormality of control is detected by the second abnormality detection means.SELECTED DRAWING: Figure 2
Patent JP-2023027020-A (JP)
Title: Natural killer cell containing chimeric antigen receptor transfected with single-chain antibody that binds specifically to adult t-cell leukemia cells
Inventor: SUMIDA YASUO
IPC: C12N5/10
Filed: 2022-08-12
Abstract: To provide a natural killer cell that can be used for presently required therapy against adult T-cell leukemia (ATL), which is a leukemia caused by infection with human T-cell leukemia virus type 1 (HTLV-1); and which develops in 5% of HTLV-1 carrier after a latency period of 30-50 years; and which is a blood cancer with an extremely poor prognosis with a 5-year survival rate of 10% or less resulted in once developed; and HTLV-1 carriers in Japan are estimated to be about 1.08 million nationwide, mainly in southern Kyushu, and about 1,000 patients die each year.SOLUTION: A natural killer cell is produced by transfecting, as part of a chimeric antigen receptor, a gene for a single-chain antibody that specifically binds to ATL cells developed by a combination of a unique sugar chain nanotechnology and a phage display method, and a method therefor is established. The cell efficiently kills ATL cells that cannot be eliminated by natural killer cells that have not been transfected, and can be used for ATL immune cell therapy.SELECTED DRAWING: Figure 3
Patent JP-2022176977-A (JP)
Title: Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
IPC: A61P35/02
Filed: 2022-08-19
Abstract: PROBLEM TO BE SOLVED: To provide immunomodulating polynucleotides, and conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. 
     SOLUTION: Immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use. 
     SELECTED DRAWING: Figure 1A 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2022164737-A (JP)
Title: Fallback beam selection procedure during failure of beam change instruction reception
IPC: H04W24/10
Filed: 2022-08-22
Abstract: PROBLEM TO BE SOLVED: To provide further improvements in the LTE technology. 
     SOLUTION: In a process of beam change, the base station transmits a beam change instruction to user equipment (UE) to indicate that the base station will change from a current beam to another beam, but the UE may not successfully receive the beam change instruction. The apparatus may be a base station that is configured to address such issues. The base station determines a change from a first beam to a second beam. The base station transmits to the UE the beam change instruction to indicate the determination of the change to the second beam upon the determination of the change to the second beam. The base station determines whether the UE has received the beam change instruction. The base station selects a third beam to communicate with the UE when the base station determines that the UE has not received the beam change instruction, where the third beam is a predefined beam. 
     SELECTED DRAWING: Figure 7 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023048120-A (JP)
Title: Computer-implemented method, upgrade system and computer program for securely transferring secret
Inventor: FLORIAN FRITZ
IPC: H04L9/08
Filed: 2022-09-12
Abstract: To provide a computer-implemented method and an upgrade system for securely transferring a secret.SOLUTION: A source computing component and a target computing component are part of a secure computing environment. The method comprises: upon the source computing component receiving from the target computing component a signed attestation document, verifying, by the source computing component, authenticity and content of the attestation document; and, upon a successful verification of the authenticity and the content, transferring, by the source computing component, the secret to the target computing component. Thereby, the attestation document attests that the target computing component is compliant to an update governance rule.SELECTED DRAWING: Figure 1
Patent JP-2022171924-A (JP)
Title: Electronic apparatus
IPC: G06F3/0481
Filed: 2022-09-21
Abstract: PROBLEM TO BE SOLVED: To provide a human interface with excellent operability or an information processing device with excellent operability. 
     SOLUTION: An information processing device includes a flexible position input unit that can supply positional information by detecting an object that gets closer or in contact. The flexible position input unit can be bent so that a first region, a second region facing the first region, and a third region overlapping with a display unit between the first region and the second region are formed. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023011608-A (JP)
Title: Thermal stable luciferase with improved resistance to inhibition by luciferin break-down products
IPC: C12N9/02
Filed: 2022-10-07
Abstract: PROBLEM TO BE SOLVED: To provide inhibitor-resistant luciferase mutants, and methods of use thereof. 
     SOLUTION: Provided are luciferases mutants that are thermally stable and exhibit improved stability in the presence of luciferin break-down products such as dehydroluciferin. Further provided is an assay system comprising inhibitor-resistant luciferase mutants and amino acid sequences of the inhibitor-resistant luciferase mutants. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023015048-A (JP)
Title: printer
IPC: G06T7/70
Filed: 2022-10-12
Abstract: PROBLEM TO BE SOLVED: To easily determine whether a nail is arranged in an appropriate position or not. 
     SOLUTION: A printer includes: a finger holding part 2 having a nail placing base 25 for placing a tip part of a nail T as a printing object, the finger holding part for placing a finger U corresponding to the nail T; a photographing part 5 for acquiring an image of the nail T placed on the finger holding part 2 from above and an image of the nail T from the side; an identification part 27 which is provided on a side surface of the nail placing base 25 for detecting a position of the nail T in such a manner that the identification part is not photographed in the image from above the nail T but is photographed in the image from the side of the nail T; an optical element which is provided in a position where the image from above the nail T and the image from the side of the nail T can be photographed by the photographing part 5, the optical element having a reference mark for indicating a reference of a height position of the nail T; and a control part. The control part determines that a position of the nail T is appropriate when a prescribed part of the nail T is in a range defined by the reference mark in the image from the side of the nail T. 
     SELECTED DRAWING: Figure 2 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2022179712-A (JP)
Title: vehicle seat
IPC: B60N2/16
Filed: 2022-10-12
Abstract: PROBLEM TO BE SOLVED: To provide a vehicle seat which properly controls behavior of a pelvis (a lumbar part) of a seating person to inhibit a compressive load from occurring in the pelvis of the seating person when an impact, such as a collision, occurs. 
     SOLUTION: A vehicle seat includes a seat cushion S1. The seat cushion S1 has: a seat cushion frame 10; and a cushion pad 1b placed on the seat cushion frame 10. The seat cushion frame 10 includes a sinking inhibition member 15 which inhibits sinking of a seating person. A fragile part 15a is provided at the sinking inhibition member 15. 
     SELECTED DRAWING: Figure 3 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023010719-A (JP)
Title: Light-emitting element
IPC: H10K50/00
Filed: 2022-10-26
Abstract: PROBLEM TO BE SOLVED: To provide a novel compound, and also to provide a highly reliable light-emitting element. 
     SOLUTION: There is provided a compound including a benzofuropyrimidine skeleton or a benzothienopyrimidine skeleton, a first substituent, and a second substituent. Each of the first substituent and the second substituent includes a furan skeleton, a thiophene skeleton, or a pyrrole skeleton. The first substituent is bonded to a pyrimidine ring included in the benzofuropyrimidine skeleton or a pyrimidine ring included in the benzothienopyrimidine skeleton. The second substituent is bonded to a benzene ring included in the benzofuropyrimidine skeleton or a benzene ring included in the benzothienopyrimidine skeleton. There is also provided a light-emitting element including the compound. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023012509-A (JP)
Title: Rna for treatment or prophylaxis of liver disease
IPC: C12N15/12
Filed: 2022-10-28
Abstract: PROBLEM TO BE SOLVED: To provide an RNA for treatment or prophylaxis of a liver disease. 
     SOLUTION: This invention provides an RNA for the treatment or prophylaxis of liver diseases, comprising at least one coding sequence, wherein the coding sequence encodes at least one peptide or protein selected from the group consisting of human collagenase MMP1, Hepatocyte Growth Factor (HGF), CCAAT/enhancer-binding protein α (CEBPA), TNF-related apoptosis-inducing ligand (TRAIL), extracellular matrix protease, hepatocyte nuclear factor 4 α (HNF4A), fibroblast growth factor 21 (FGF21), opioid growth factor receptor-like 1 (OGFRL1), Relaxin 1 (RLN1), Relaxin 2 (RLN2) and Relaxin 3 (RLN3), or a fragment or a variant of any of these peptides or proteins. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023025097-A (JP)
Title: Information processor, method, and program
IPC: G06Q50/10
Filed: 2022-11-24
Abstract: PROBLEM TO BE SOLVED: To provide a technique capable of further diversifying development of a match with an opponent with whom a user plays a match in a TCG (Trading Card Game). 
     SOLUTION: An information processor manages matching rally information regarding a matching rally, and match information of each user who participates in the matching rally, and stores information on plural decks usable by a user in the matching rally as registered deck information in association with the matching rally information. A control part executes the steps of: determining a match opponent user who plays a match with one user; presenting the one user with information regarding registered deck information of the match opponent user before registering win/loss information of one user and the match opponent user; receiving designation of a deck used for a match from one user from among registered deck information of the one user after presentation by the step of presenting to a user; and updating match information to be managed in response to designation of a deck by each match opponent user. 
     SELECTED DRAWING: Figure 14 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023027172-A (JP)
Title: Norrin induced expression of genes and use thereof to treat disease
IPC: A61K39/395
Filed: 2022-12-05
Abstract: PROBLEM TO BE SOLVED: To provide new use of norrin. 
     SOLUTION: A use of norrin in manufacture of pharmaceuticals for a method for restabilizing blood vessels to prevent familial exudative vitreoretinopathy is provided, wherein the method includes the steps of: exposing a vessel to an anti-VEGF agent selected from bevacizumab, ranibizumab, lapatinib, sunitinib, sorafenib, axitinib, pazopanib, or a combination thereof as an adjuvant; and simultaneously exposing the vessel to norrin to reduce gene expression of at least one gene of BMP2, CLCL6, IL12B in endothelial cells, thereby restabilizing the vessel against its leakage. 
     SELECTED DRAWING: Figure 3 
     COPYRIGHT: (C)2023,JPO&INPIT
Patent JP-2023021426-A (JP)
Title: game machine
IPC: A63F7/02
Filed: 2022-12-19
Abstract: PROBLEM TO BE SOLVED: To provide a game machine capable of detecting abnormality in setting information. 
     SOLUTION: A game machine includes: means for acquiring special information with entry of game balls into ball entry means as an opportunity; means for executing special information determination processing for determining whether the special information satisfies a privilege granting condition; means for granting privilege to a player when the special information is determined to satisfy the privilege granting condition; means for changing setting of a winning probability as a probability determined such that the special information satisfies the privilege granting condition; setting information storage means for storing setting information as information for determining setting of a winning probability; and means for determining whether setting information stored in the setting information storage means agrees with setting information at the time of acquisition of special information stored as setting information at the time of acquisition of special information as an object of the special information determination processing following execution of the special information determination processing. 
     SELECTED DRAWING: Figure 98 
     COPYRIGHT: (C)2023,JPO&INPIT