baber/WOPTO huggingface dataset:
Patent ES-2383799-T3 (ES)
Title: Procedimiento para la preparación del estereoisómero de glicopirronio con configuración R,R (o S,S)
Inventor: NOE CHRISTIAN R
IPC: A61K31/381
Filed: 2003-12-18
Granted: 2012-06-26
Abstract: Procedimiento para la preparación a) del estereoisómero 3R, 2'R del bromuro o yoduro de glicopirronio (fórmula II: A >= Br ó I), o bien b) del estereoisómero 3R, 2'S idéntico, en lo referente a la configuración relativa de sus dos centros quirales, del análogo de tienilo de glicopirronio (fórmula VI: A >= Br ó I) caracterizado porque se emplea a) la mezcla de diastereoisómeros constituida por el isómero 3R, 2'R y el isómero 3R, 2'S (fórmula III), la cual se compone de una parte de alcohol enantiopuro y una parte de ácido racémico, o bien b) la mezcla de diastereoisómeros constituida por el isómero 3R, 2'S y el isómero 3R, 2'R (fórmula VII), la cual se compone de una parte de alcohol enantiopuro y de una parte de ácido racémico y porque las mezclas cuaternarias de los citados diastereoisómeros (de las fórmulas III y VII) se obtienen por una cuaternización de las respectivas mezclas terciarias, básicas, de diastereoisómeros, y porque en la cuaternización el estereoisómero especialmente bien cristalizable que se ha de aislar en cada caso, de la fórmula II, respectivamente de la fórmula IV, después de la reacción se obtiene fuertemente enriquecido en forma de precipitado, utilizándose disolventes o mezclas de disolventes que contienen preferentemente al menos uno del grupo constituido por alcoholes ramificados o no ramificados de bajo peso molecular tales como metanol, etanol, isopropanol, 1-propanol, terc-butanol, isobutanol. n-butanol, así como acetona, butanona, acetonitrilo, y/o las mezclas cuaternarias de los diastereoisómeros citados (eventualmente en forma ya enriquecida) se recristalizan, y el estereoisómero especialmente bien cristalizable que se ha de aislar en cada caso, de la fórmula II ó VI, se obtiene fuertemente enriquecido en forma de precipitado, utilizándose para la disolución metanol y/o etanol, y la cristalización se induce con acetato de etilo y/o terc-butilmetiléter.
Patent ES-2250921-T3 (ES)
Title: Nuevo derivado de 2-piridiletilbenzamida.
Inventor: MANSFIELD DARREN JAMES
IPC: C07D213/61
Filed: 2003-08-08
Granted: 2006-04-16
Abstract: Nuevos compuestos fungicidas, al procedimiento para su preparación, a las composiciones fungicidas que comprenden estos compuestos y también a su uso en el campo de la agricultura como fungicidas.
Patent ES-2299748-T3 (ES)
Title: Peptido inmunogenico de ptpkr.
Inventor: CASTELLI CHIARA
IPC: C12N5/09
Filed: 2003-11-12
Granted: 2008-06-01
Abstract: El péptido inmunogénico PTPRK Gly677-->Arg de la SEQ ID N. 1.
Patent ES-2260692-T3 (ES)
Inventor: DENKER WOLFGANG
IPC: B21B31/20
Filed: 2003-07-25
Granted: 2006-11-01
Abstract: Device for bending rollers in a multiple roller rolling mill comprises a vertical positioning unit (10) assigned to bending blocks (5, 5a) of one roll stand (6), to a plunger cylinder (7) and to the bending blocks (5', 5a') of the opposite-lying roll stand (6').
Patent ES-2542329-T3 (ES)
Inventor: LAMPING NORBERT
IPC: C12N15/62
Filed: 2003-10-09
Granted: 2015-08-04
Abstract: A modular antigen-transporting molecule (MAT) comprising one each of a translocation module (TrM), a targeting module (TaM) and an antigen module (AM), is new.  Modular antigen-transporting molecule (MAT) comprising at least one each of translocation module (TrM), targeting module (TaM) and antigen module (AM) is new. TrM is able to transport MAT from the extracellular space into a cell; TaM directs transport of MAT to organelles involved in processing of antigens (Ag) or loading of MHC (major histocompatibility complex) molecules, and AM determines the specificity of the immune response induced by MAT.  Independent claims are also included for the following: (1) method for preparing MAT;  (2) nucleic acid (I) that encodes MAT;  (3) vector containing (I) and preferably at least one of promoter, antibiotic or antimycotic resistance gene;  (4) primary cells or cell lines containing a vector of (3) or (I);  (5) vesicles, especially exosomes, deoxosomes or liposomes that contain at least one MAT, (I) or the vector of (3);  (6) immunoglobulins (Ig), or their fragments, that recognize MAT, prepared by immunization of a human or animal;  (7) method for identifying substances that inhibit or stimulate presentation of Ag through the MHC;  (8) method for identifying specific epitopes of Ag;  (9) in vitro cultured cells, human or animal, that have been treated with MAT, (I), the vector of (3) or vesicle of (5) and show modulated Ag presentation; and  (10) method for preparing antibodies (Ab), using MAT, (I), vesicles of (5), or cells of (4) or (9), by immunization.
Patent ES-2366784-T3 (ES)
Inventor: FELDMANN ANDRE
IPC: B65B25/06
Filed: 2004-12-23
Granted: 2011-10-25
Abstract: The packaging unit for foodstuffs, in particular, for fish and fish products comprises a shell (10) with a bottom (12) and at least one side (14, 16) joining the bottom along a curved fold line (18, 20), and a foil serving as a cover for the shell.
Patent ES-2350930-T3 (ES)
Inventor: DOBRZANSKI PRZEMYSLAW
IPC: B09B1/00
Filed: 2004-07-22
Granted: 2011-01-28
Abstract: Method of removal of open landfills and storage of the municipal and industrial waste materials by storing them in concrete silos which are erected directly on the existing landfill. The silo is constructed by ring-shaping stages, carrying out first excavation and then in cycles subsequent excavations having depth of 1,5 - 2,0 m whereby the clean soil is put aside. After execution of the ring-shaped concrete silo walls, the insulation is fastened on the surfaces of the silo. Then a thick-plastic concrete is poured forming the bottom of the silo. Then the wastes together with polluted soil removed from adjacent area are relocated into the silo. A concrete cover in form of flat dome is carried out, this cover being additionally protected using insulating foil. The filled and effectively closed silo is covered by putting several layers of unpolluted soil gained from excavation.
Patent ES-2293196-T3 (ES)
Inventor: MEGGIOLAN MARIO
IPC: B62K25/02
Filed: 2004-05-31
Granted: 2008-03-16
Abstract: A releasably locking device (1) for fixing a bicycle component to a bicycle frame, and a clamping element (4) for such a device are described. The device (1) comprises a traction rod (2) associated with a rotation cam (9) extending in a housing (8). The rotation of the cam (9) is driven by a lever-operated manual actuation system (11) between a clamping operating position and a release position. According to the invention, the rotation cam (9) comprises two ends (21, 22) drivable into synchronous rotation through said lever-operated manual actuation system (11). <IMAGE>
Patent ES-2273218-T3 (ES)
Inventor: VAN LOON LAURENTIUS PETRUS JOS
IPC: A47B51/00
Filed: 2004-02-12
Granted: 2007-05-01
Abstract: A catering assembly for use with an aircraft or train includes a wall (1) provided with a multiplicity of slots (2) running in the vertical direction with undercuts as well as a multiplicity of essentially block-shaped modules (6) with runners (14) on the rear that can be accommodated in the undercut slots (2), the cross-sectional shape of which, viewed in the horizontal plane, corresponds to the cross-sectional shape of the undercut slots (2), viewed in the horizontal plane. The catering assembly furthermore includes lifting elements for raising or lowering the module (6), the runners (14) of which have been accommodated in a the undercut slot (2), over the wall. It is preferable if the slots (2) are widened in places (15) such that a runner (14) can be inserted here in the horizontal direction so as then to hook into the undercut slot (2) after being moved vertically.
Patent ES-2353306-T3 (ES)
Inventor: CHENG JIE
IPC: C07D307/84
Filed: 2004-07-28
Granted: 2011-03-01
Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
Patent ES-2357603-T3 (ES)
Title: Método para producir proteínas gamma-carboxiladas.
Inventor: FENGE CHRISTEL
IPC: A61K38/00
Filed: 2004-10-12
Granted: 2011-04-28
Abstract: Una célula huésped eucariota que comprende al menos un vector de expresión que comprende: una molécula de ácido nucleico que codifica una proteína que requiere gamma-carboxilación y secuencias control asociadas a la expresión que comprenden un primer promotor y una molécula de ácido nucleico que codifica una γ-glutamil carboxilasa y secuencias control asociadas a la expresión que comprenden un segundo promotor, en el que el primer promotor se selecciona de promotor temprano inmediato del citomegalovirus humano (hCMV), pEF-1α, pRSV o pUbC, y el segundo promotor se selecciona de promotor temprano inmediato de SV40, promotor FIX minimizado o promotor de quinasa timidina de HSV.
Patent ES-2369139-T3 (ES)
Title: Proteinas de unión a gag.
Inventor: KUNGL ANDREAS J
IPC: C07K14/54
Filed: 2004-12-02
Granted: 2011-11-25
Abstract: Método para modificar una región de unión a GAG (glucosaminoglicano) que es una hélice α C-terminal de una quimoquina, caracterizado porque comprende las etapas de introducir por lo menos un aminoácido básico en dicha hélice α C-terminal y/o delecionar por lo menos un aminoácido voluminoso y/o ácido en dicha hélice α C-terminal, de manera que dicha quimoquina presenta una afinidad de unión a GAG de Kd <=10 mM, preferentemente <=1 mM, todavía más preferentemente <=0,1 mM, y en el que la afinidad de unión a GAG de dicha quimoquina se encuentra incrementada en comparación con la afinidad de unión a GAG de la quimoquina de tipo salvaje respectiva.
Patent ES-2338236-T3 (ES)
Inventor: FULLBECK WOLFGANG F
IPC: F16L25/00
Filed: 2004-11-05
Granted: 2010-05-05
Abstract: A fitting for a sanitary hose assembly includes a rigid, tubular stem, a cylindrical ferrule, and an annular seal, which coact with the end of the hose to achieve a uniformly leakproof seal for a material flow path through the hose and into the fitting. One end of the ferrule extends over the outer end of the hose, such that the ferrule engages the hose and extends slightly beyond the hose. An inner end of the stem extends through an outer end of the ferrule and into the hose, such that the outer surface of the stem frictionally engages the internal surface of the hose. The stem has an outer end adapted to connect to a similar structure, internal threads which cooperatively engage similar threads on the ferrule, and an outwardly directed land adjacent the threads. The threaded coupling of the stem and the ferrule fixes their relative axial relationship, and also axially compresses the annular seal between. The ferrule is radially crimped to compress the end of the hose between the stem and the ferrule. This combination of components provides a circumferentially uniform and leakproof seal between the hose and the fitting, at relatively low cost.
Patent ES-2322599-T3 (ES)
Inventor: IBANEZ MORENO JOSE VICENTE
IPC: E05B15/02
Filed: 2005-12-15
Granted: 2009-06-23
Abstract: It is suitable for installation on a doorframe, with a casing (1) containing:  a retaining piece (2) that is selectively lockable and releasable by means of a lever mechanism, which is articulated in relation to a respective articulation pivot (A1, A2) of said casing (1), governed by an electromagnetic actuator (3), so that when said retaining piece (2) is released, it allows the door to be opened and when it is locked it retains a latch that locks said door, and  a detecting device (4), which is usually a switch, which detects the open or closed door situations, operated by a pushing element (6).    Said electromagnetic actuator (3) and said detecting device (4) are electrically connected to a multiple connector (5) housed inside said casing (1) and which permits electrical connection with the exterior.
Patent ES-2311937-T3 (ES)
Inventor: PETERSSON MIKAEL
IPC: B29C70/34
Filed: 2005-12-20
Granted: 2009-02-16
Abstract: The present invention relates to a stiffening element (1) and a method for manufacturing of a stiffening element (1) of composite material, which stiffening element (1) is provided for attachment to a curved shell surface (9). A substantial flat blank (29) of composite material comprising a first (13) and a second (15) essentially parallel elongated edge is provided for forming in the web (3) of the stiffening element (1) at least one rounded bulge (19) having a conical form tapering from the first edge (13) to a first folding line (17). Thereby is achieved a curved flange (5), which first folding line (17) essentially merges with an apex of the rounded bulge (19).
Patent ES-2324170-T3 (ES)
Inventor: CACERES PATRICK
IPC: A61B19/00
Filed: 2005-06-14
Granted: 2009-07-31
Abstract: The compress has a cover (5) with high water absorbing capacity polymer particles (6) disposed at its interior. The particles are non-toxic and are initially at a dry state. The cover is closed on its edges by weld line having a width of 3-7 millimeter. The compress is associated with a water bag (4) in an outer sachet of an article e.g. bandage. The cover is fabricated in a manner to form several elongated compartments. An independent claim is also included for a process for manufacturing a compress.
Patent ES-2582185-T3 (ES)
Title: Aparato para la medida de glucosa en sangre usando medidas de impedancia de tejido corporal sub-dérmico
Inventor: OLLMAR STIG
IPC: G01N33/49
Filed: 2005-02-04
Granted: 2016-09-09
Abstract: Un aparato para la medida o control de nivel de glucosa en sangre de un sujeto mediante medida de la impedancia de un tejido corporal subdérmico, del sujeto que da lugar a una corriente eléctrica que fluye a través de dicho tejido corporal y determinación de un nivel de glucosa en sangre de dicho sujeto en base a la impedancia medida, en el que dicho aparato es un equipo de cuatro puntos configurado para llevar a cabo un análisis de impedancia en 4 puntos, que comprende - un par de electrodos de inyección adaptados para la inyección de corriente eléctrica en el tejido corporal, en el que se pasa la corriente eléctrica por tejido subdérmico o subcutáneo de dicho sujeto; - un par de electrodos de detección adaptados para detectar el voltaje provocado por dicha corriente inyectada por los electrodos de inyección, tras fluir a través del tejido corporal; - un medio para la medida de la impedancia del tejido corporal sub-dérmico entre dichos electrodos de inyección y dichos electrodos de detección; - un microprocesador conectado de forma operativa a los medios para la medida de la impedancia y que es programado para determinar un nivel de glucosa en la sangre del sujeto en base a una comparación de la impedancia medida con una interrelación predeterminada entre la impedancia del tejido corporal sub-dérmico y el nivel de glucosa.
Patent ES-2330536-T3 (ES)
Inventor: PARK THEODOR
IPC: B65D35/22
Filed: 2005-02-23
Granted: 2009-12-11
Abstract: A multi-chamber tube package which comprises a first tube chamber having a tube nozzle channel extending from a tube shoulder and terminating in an outlet, and a second tube chamber having a tube nozzle channel terminating in an outlet adjoining the first outlet. The tube nozzle channels enable the dispensing of the multiple preparations from the chambers. The nozzle channels lead to an outlet where the first preparation and the second preparation meet and coalesce to form a common strand. The two channels and the chambers associated with them have a defined ratio to each other. One nozzle channel may be subdivided into one or more parallel branches and/or the nozzle channels may have orifice rims or edges which lie on different planes.
Patent ES-2360826-T3 (ES)
Inventor: KILIAN KRYZSZTOF
IPC: B61L1/04
Filed: 2005-07-15
Granted: 2011-06-09
Abstract: A detection system is disclosed comprising: first sensing means (2), located adjacent a first rail (16) of a railway for detecting and communicating proximity along the first rail of a first wheel of a wheelset; and second sensing means (4), located adjacent a second rail (18) of the railway for detecting and communicating proximity along the second rail of a second wheel of the wheelset; wherein the first sensing means and the second sensing means are disposed along a common line generally perpendicular to at least one of a longitudinal axis of at least one of the first rail and the second rail and a tangent of at least one of the first rail and the second rail; wherein the first sensing means and the second sensing means are not strain gages; and wherein the first sensing means and the second sensing means are in communication with means for monitoring (8) the first sensing means and the second sensing means; and means (12), in communication with at least one of the first sensing means, the second sensing means and the means for monitoring the first sensing means and the second sensing means, for processing output of at least one of the first sensing means and second sensing means.
Patent ES-2315913-T3 (ES)
Inventor: DRIESSEN FRANCISCUS JOHANNES CORNELIS
IPC: A47C3/28
Filed: 2005-09-15
Granted: 2009-04-01
Abstract: An embodiment of the present invention discloses a highchair with adjustable seat, including a frame and support device, which are connected to the frame and which form a bearing plane for supporting the frame on a floor. The frame includes at least two substantially parallel uprights which in a position of use of the chair protrude at least partly obliquely above the bearing plane. Further, the highchair includes a part adjustable along the uprights, which is provided with an engaging device for engaging the two uprights, wherein the engaging device includes at least one receiving chamber for engaging part of the way round the upright.
Patent ES-2606664-T3 (ES)
Title: Mezcla de polímeros y composiciones y procedimientos para usarlos
Inventor: COSMAN MICHAEL
IPC: C08L81/04
Filed: 2005-09-02
Granted: 2017-03-27
Abstract: Un sellador multicapa que comprende: a) una primera capa selladora; b) una segunda capa selladora; y c) una capa selladora intermedia que comprende una mezcla de polímeros que comprende al menos un (i) componente de polisulfuro y al menos un (ii) componente de politioéter, en donde la capa selladora intermedia se encuentra entre la primera capa selladora y la segunda capa selladora, y en donde o bien el primer o bien el segundo sellador se basan en la química de polisulfuro y el otro del primer o el segundo sellador se basa en la química de politioéter.
Patent ES-2484944-T3 (ES)
Title: Medicamento y sistema para la administración percutánea de un medicamento
Inventor: BARNIKOL-KEUTEN DORIS
IPC: A61M35/00
Filed: 2005-10-11
Granted: 2014-08-12
Abstract: Una microemulsión que después de atomización con un gas propulsor se encuentra enriquecida con oxígeno, que contiene al menos un medicamento para la administración percutánea, caracterizada por que el enriquecimiento con oxígeno existe mediante atomización con un gas propulsor que contiene oxígeno o mediante atomización con un gras propulsor de una microemulsión, que contiene un aditivo para mejorar la alimentación de oxígeno
Patent ES-2308572-T3 (ES)
Title: Procedimiento mejorado de fabricacion de anhidrido (met) acrilico.
Inventor: PAUL JEAN-MICHEL
IPC: C07C57/075
Filed: 2005-10-18
Granted: 2008-12-01
Abstract: Método de fabricación de anhídrido (met)acrílico por transanhidrificación entre el ácido (met)acrílico y el anhídrido acético, en presencia de aire y en presencia de al menos un inhibidor de polimerización, caracterizado porque el inhibidor de polimerización se escoge en el grupo constituido por (a) las sales metálicas del ácido tiocarbámico o ditiocarbámico y sus mezclas con un derivado fenólico o la fenotiazina y sus derivados y b) los compuestos N-oxilos en mezcla con el con el 2,6-diterbutil 4-metil fenol tomado solo o en presencia de 2,4-dimetil 6-terbutil fenol.
Patent ES-2362289-T3 (ES)
Inventor: BOOGERS JEROEN
IPC: B01J31/24
Filed: 2005-12-05
Granted: 2011-06-30
Abstract: A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.
Patent ES-2366706-T3 (ES)
Title: Composiciones de yodocarbono estabilizadas.
Inventor: SINGH RAJIV R
IPC: C09K5/04
Filed: 2005-12-21
Granted: 2011-10-24
Abstract: Una composición de transmisión de calor que comprende: (a) al menos un yodocarbono; y (b) al menos un compuesto basado en dieno, en el cual dicho producto basado en dieno es un dieno C3-C5 o un compuesto que puede formarse por reacción que implica un dieno C3-C5.
Patent ES-2306319-T3 (ES)
Title: Forceps electroquirurgico con placas selladoras de cierre lento y metodo de sellar tejidos.
Inventor: ODOM DARREN
IPC: A61B18/12
Filed: 2006-03-30
Granted: 2008-11-01
Abstract: Fórceps electroquirúrgico bipolar (10) para sellar tejidos, que comprende: al menos un miembro (12) de vástago que tiene un conjunto (100) de efector final, dispuesto en un extremo distal del mismo, incluyendo el conjunto (100) de efector final unos miembros (110, 120) de mordaza que son móviles desde una primera posición con una relación de separación, uno con respecto al otro, hasta al menos una posición subsiguiente en la que los miembros (110, 120) de mordaza cooperan para agarrar el tejido entre ellos; y cada uno de los miembros (110, 120) de mordaza incluye una placa selladora (112, 122) que comunica energía electroquirúrgica a través del tejido sujeto entre ellas, incluyendo al menos una de las placas selladoras (112, 122) un miembro (150) de tope ajustable acoplado al menos a un controlador (155), estando configurado el al menos un miembro (150) de tope ajustable para separar las placas selladoras (112, 122) en una distancia (6) de separación predeterminada, caracterizado porque el al menos un controlador (300) está configurado para ajustar el al menos un miembro (150) de tope ajustable para cerrar las placas selladoras (112, 122) con una velocidad predeterminada.
Patent ES-2330551-T3 (ES)
Title: Adhesivo de pp de alta temperatura.
Inventor: ANKER MARTIN
IPC: C09J123/10
Filed: 2006-10-13
Granted: 2009-12-11
Abstract: Composición de adhesivo, que comprende un componente de polipropileno que comprende al menos un copolímero de propileno heterofásico, en el que la composición de adhesivo muestra una resistencia a desprendimiento a 110ºC mayor de 160 N/cm y un valor para MFR2 de 5 g/10 min o mayor.