Patent SG-11201907548P-A (SG)
Title: Humanized antibody for treating or preventing cognitive disorders, process for producing the same, and agent for treating or preventing cognitive disorders using the same
Inventor: EGUCHI HIROSHI
IPC: C07K16/44
Filed: 2018-02-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIP0 I PCT omit VIII °nolo OH loom!! VIII 1110110111110 Hs (10) International Publication Number WO 2018/154390 Al (51) International Patent Classification: C07K 16/18 (2006.01) C07K 16/44 (2006.01) (21) International Application Number: PCT/IB2018/000249 (22) International Filing Date: 27 February 2018 (27.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: JP 2017-035594 27 February 2017 (27.02.2017) JP (71) Applicants: TEIJIN PHARMA LIMITED [JP/JP]; 2-1, Kasumigaseki 3-chome, Chiyoda-ku, Tokyo, 100-0013 (JP). MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US). (72) Inventors: EGUCHI, Hiroshi; c/o Teijin Pharma Limited, 2-1, Kasumigaseki 3-chome, Chiyoda-ku, Tokyo, 100-0013 (JP). MURAKAMI, Takashi; c/o Teijin Pharma Limited, 2-1, Kasumigaseki 3-chome, Chiyoda-ku, Tokyo, 100-0013 (JP). NAMIKI, Naoko; c/o Teijin Pharma Limited, 2-1, Ka- sumigaseki 3-chome, Chiyoda-ku, Tokyo, 100-0013 (JP). TANOKURA, Akira; c/o Teijin Pharma Limited, 2-1, Ka- sumigaseki 3-chome, Chiyoda-ku, Tokyo, 100-0013 (JP). BAKER, Jeanne, E.; c/o Merck Sharp & Dohme Corp., 901 S. Califrnia Avenue, Palo Alto, CA 94304 (US). PARMENTIER BATTEUR, Sophie; c/o Merck Sharp & Dohme Corp., 770 Surrmeytown Pike, West Point, PA 19486 (US). JABLONSKI, Angela, Marie; c/o Merck Sharp & Dohme Corp., 770 Sumneytown Pike, West Point, PA 19486 (US). MALASHOCK, Daniel, Stephen; c/o Merck Sharp & Dohme Corp., 901 S. Califrnia Avenue, Pa- lo Alto, CA 94304 (US). MIECZKOWSKI, Carl; c/o Mer- ck Sharp & Dohme Corp., 901 S. Califrnia Avenue, Palo Al- to, CA 94304 (US). RAGHUNATHAN, Gopalan (raghu); c/o Merck Sharp & Dohme Corp., 901 S. Califrnia Avenue, Palo Alto, CA 94304 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, O TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1)) with sequence listing part of description (Rule 5.2(a)) GO (54) Title: HUMANIZED ANTIBODY FOR TREATING OR PREVENTING COGNITIVE DISORDERS, PROCESS FOR PRO- DUCING THE SAME, AND AGENT FOR TREATING OR PREVENTING COGNITIVE DISORDERS USING THE SAME \" (57) : The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phos- C phorylated at the serine at position 413.