Patent SG-11201807785V-A (SG)
Title: Neuroactive steroids, compositions, and uses thereof
Inventor: KANES STEPHEN
IPC: A61K31/56
Filed: 2017-03-08
Abstract: Extrasynapticx(336 1250 0 Compound 9 1000 Diazepam '47; 750 4- , 0 500 2 0 0.01 Concentration (PM) FIG. 1A W O 20 17 / 15 6 103 Al 1 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/156103 Al 14 September 2017 (14.09.2017) WIPO I PCT (51) International Patent Classification: (72) Inventor; and A61K 31/57 (2006.01) A61K 31/575 (2006.01) (71) Applicant : COLQUHOUN, Helen [US/US]; 23 Regis A61K 31/56 (2006.01) A61K 31/58 (2006.01) Road, Arlington, MA 02474 (US). 111111111111110111011111111111010111110 0111111111111101011111011111111111110111111 (21) International Application Number: PCT/US2017/021325 (22) International Filing Date: 8 March 2017 (08.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/305,279 8 March 2016 (08.03.2016) US 62/355,174 27 June 2016 (27.06.2016) US 62/355,669 28 June 2016 (28.06.2016) US 62/360,762 11 July 2016 (11.07.2016) US 62/360,758 11 July 2016 (11.07.2016) US (71) Applicant: SAGE THERAPEUTICS, INC. [US/US]; 215 First Street, Cambridge, MA 02142 (US). (72) Inventor: KANES, Stephen, Jay; 125 Guernsey Rd, Swartmore, PA 19081 (US). (74) Agent: MCCARTY, Catherine, M.; LANDO & ANA- STASI, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [Continued on next page] (54) Title: NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF (57) : Described herein are methods of treating a disorder, e.g., tremor, e.g., essential tremor; depres- sion, e.g., postpostum depression; and anxiety disorder, the method compris- ing administering to a human subject suffering from a disorder, e.g., tremor, e.g., essential tremor; depression, e.g., postpostum depression, an anxiety dis- order with a neuroactive steroid or a composition comprising a neuroactive steroid (e.g., pregnanolone, allopreg- nanolone, alphadalone, ganaxolone, or alphaxolone). WO 2017/156103 Al MIDEDIMOMOIDEIRMEMOMOHIMOMMIUMEMOIS (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3))