baber/WOPTO huggingface dataset:
Patent NZ-532120-A (NZ)
Title: Biological discovery using gene regulatory networks generated from multiple-disruption expression libraries
Inventor: IMOTO SEIYA
IPC: G16B5/10
Filed: 2002-09-26
Abstract: A method for constructing a gene network comprises: (a) maintaining in computer memory a quantitative disruptant data library for a set of genes of an organism; (b) creating a gene expression matrix from the library; (c) generating network relationships between the genes comprising a Bayesian computational model; (d) determining if one or more groups of genes is expressed differently from other of the groups of genes and (e) selecting a gene from one of the groups of genes that are expressed differently from the other groups of genes. The library including expression results based on disruption of each gene in the set of genes, quantifying an average effect and a measure of variability of each disruption on each other of the genes. The Bayesian model comprises minimizing a BNRC criterion. The step of minimizing a BNRC criterion can use a non-linear curve fitting method such as regression spline bases and B-splines and can further comprises selecting a Bayesian mode using a backfitting algorithm, Akaike's information criterion or maximum likelihood estimation.
Patent NZ-533644-A (NZ)
Title: Concrete material suitable for paving and having high draining capability
Inventor: TERRUZZI CLAUDIO
IPC: E01C7/14
Filed: 2004-06-18
Abstract: A concrete material suitable for paving and having a high draining capability is disclosed, which comprises cement aggregate and water, wherein the amount of cement is between 250 and 450 kg per cubic meter, a ratio by weight of water to cement is maintained at less or equal to 0.35, to form a viscous mixture; wherein a major portion by weight of the aggregate consists of a big aggregate obtained by crushing of stony material and having substantially homogeneous linear dimensions; and wherein the mixture comprises a glass yarn of the AR type that resists alkali and textured in the form of a continuous filament; so that a microreinforcement and a wide homogeneously distributed porosity is formed in the concrete mixture.
Patent NZ-534786-A (NZ)
Title: Novel 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for making same and pharmaceutical compositions containing same
Inventor: BADORC ALAIN
IPC: A61P27/02
Filed: 2003-04-02
Abstract: 1,2,3-substituted indolizine derivatives of formula (I) are disclosed, wherein the variables are as defined in the specification. These compounds of formula (I) are inhibitors of basic fibroblast growth factors (FGFs) and are suitable for the treatment of carcinomas of the lung, breast, prostate, esophagus, colon and stomach, melanomas, gliomas, lymphomas, and leukemias; and they are also suitable for the treatment of atherosclerosis, post-angioplasty restinosis, diseases linked to complications which appear following the fitting of endovascular prostheses and/or aorto-coronary artery by-pass surgery or other vascular transplants, cardiac hypertrophy or diabetic retinopathies.
Patent NZ-535326-A (NZ)
Title: Self-cleaning fluid filter system
Inventor: GORDON ROBERT R
IPC: F04B53/20
Filed: 2003-02-18
Abstract: A self-cleaning, back-washable filter apparatus (12) and method for use with a pumping apparatus (14) which is lowered into a fluid to be filtered. The filter apparatus (12) includes a filter basket (54) having a manifold (50) with several tubes (38) extending therefrom. A filter element (34) encases at least a portion of the filter basket to block sand or other solid or dissolved particles from entry into the pump intake. Pressurized gas or fluid is directed to the manifold (50) and then through perforations (80) or jets distributed along the length of the tubes (38). Bursts of the pressurized gas are directed from the perforations (80) or jets to the interior of the filter apparatus (12) and then sprayed from the perforations (80) or jets in an outwardly direction against interior surfaces of the filter element (34). Air or fluid bursts from the perforations (80) impinge upon the interior surfaces of the filter (34) and dislodge or expel entrapped particulate material.
Patent NZ-540024-A (NZ)
Title: 12mm external box corner flashing
Inventor: KENNEDY ANTHONY DAVID
Filed: 2005-05-16
Abstract: A metal flashing, comprising a single length of metal with eleven length-wide folds running parallel to each other and parallel to said flashing's longitudinal edges giving 12 external faces, first said length-wide fold bent at 180 degrees to form a hem, second and third said length-wide folds each bent at 90 degrees in the same direction as said first length-wide fold, fourth to eighth said length-wide folds each bent at 90 degrees in the opposite direction to said first, second and third length-wide folds, ninth and tenth said length-wide folds each bent at 90 degrees in the opposite direction to said fourth to eighth length-wide folds, eleventh said length-wide fold bent at 180 degrees in the same direction as said ninth and tenth length-wide folds to form a hem.
Patent NZ-549034-A (NZ)
Title: Hand-holdable vacuum cleaners
Inventor: WALKER ANDREW
Filed: 2006-08-09
Abstract: A hand-holdable vacuum cleaner comprises an electric motor and an airflow pathway including an inlet for dirty air, an outlet for clean air and a collection chamber. The inlet is located at on end of a rigid elongate nose which is pivotable through an angle of 135º.
Patent NZ-563350-A (NZ)
Title: Improvements in and relating to attachments, brackets and support assemblies
Inventor: MAGUIRE PATRICK DAVID
IPC: B62J7/02
Filed: 2007-11-12
Abstract: An attachment device, a bracket assembly and a support assembly, for use on bicycles, are disclosed. The attachment device includes a ratchet or gripping mechanism, a strap fixed to a body portion of the attachment with the free end being passed around part of the frame into the gripping mechanism. The bracket assembly includes two attachment devices that are connected to each other via at least one support member. The support assembly includes a support frame having at least two support members and attachment devices.
Patent NZ-566808-A (NZ)
Title: Electrodeposition method for electrocoating full panel easy open end or lid of a can
Inventor: ORAVITZ JEFFREY J
IPC: C09D5/44
Filed: 2006-10-03
Abstract: Disclosed is a method for electrocoating a surface that is 50% or greater of the surface uncoated of a full panel easy open end comprising electrodepositing on the end an electrodepositable coating that is epoxy free and comprises a crosslinker in an amount of 30 wt.% or more based on total solid weight of the coating. Full panel easy open ends prepared by the methods are also disclosed.
Patent NZ-573570-A (NZ)
Title: Treating psychological conditions using telenzepine and one or more antidepressants
Inventor: SEED BRIAN
IPC: A61K45/06
Filed: 2007-06-15
Abstract: Disclosed herein is the use of a combination of telenzepine and one or more antidepressants selected from the group consisting of citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, milnacipran, mirtazapine, venlafaxine, duloxetine, desvenlafaxine, and sibutramine in the manufacture of a medicament for treating one or more psychological conditions. Also disclosed are pharmaceutical compositions comprising a mixture of telenzepine and one or more antidepressants selected from the group consisting of escitalopram, fluoxetine, fluvoxamine, paroxetine, milnacipran, mirtazapine, duloxetine and desvenlafaxine. Furthermore, a kit comprising a combination of therapeutically effective amounts of telenzepine and the antidepressant fluoxetine is disclosed.
Patent NZ-580813-A (NZ)
Title: Kinetic determination of peracid and/or peroxide concentrations
Inventor: KRAUS PAUL R
IPC: G01N35/00
Filed: 2008-03-07
Abstract: Disclosed is a method of determining a peracid and/or peroxide concentration. The disclosed method comprises: i. preparing a sample mixture including a reagent including an iodide compound with a pH adjusted to an alkaline range, and a sample of a use composition having a concentration of peracid and a concentration of peroxide to be determined; ii. collecting response data indicative of absorbance of the sample mixture as a function of time; and iii. determining the concentration of the peracid and the concentration of the peroxide in the use composition based on the response data. Determining the concentration of the peracid and the concentration of the peroxide in step iii includes: a) determining a best fit linear relationship between the data indicative of the absorbance of the sample mixture and time, the best fit linear relationship including a slope and a y-intercept; b) calculating the peracid concentration based on the y-intercept; and c) calculating the peroxide concentration based on the slope.
Patent NZ-587066-A (NZ)
Title: Substituted heteroarylamide oxazepinopyrimidone derivatives
Inventor: FAYOL AUDE
IPC: C07D519/00
Filed: 2009-01-27
Abstract: Disclosed are oxa-diaza-benzocycloheptene derivatives represented by general formula (I). Processes for preparing the compounds are also disclosed. Also disclosed is the use of the compounds of formula (I) for treating Alzheimer's disease, Parkinson's disease, tauopathies, vascular dementia; acute stroke, traumatic injuries; cerebrovascular accidents, brain cord trauma, spinal cord trauma; peripheral neuropathies, retinopathies, glaucoma, non-insulin dependent diabetes; obesity; manic depressive illness; schizophrenia; alopecia; cancers; parenchymal renal diseases, muscle atrophy, malaria, Pemphigus vulgaris, bone diseases or diseases caused by abnormal GSK3-beta activity.
Patent NZ-589893-A (NZ)
Title: Method and arrangement for animal management
Inventor: DAVIS KENDRA
IPC: A01K1/12
Filed: 2009-06-15
Abstract: A method for management of animals which are allowed to move in a specified area, the area comprising several grazing paddocks 12a, 12b, 12c, 12d, 12e, 12f where the animals can graze, a milking area 13 where the animals can be milked, and a number of automatic gates 17 that during certain time periods allow the animals to move between the paddocks 12a, 12b, 12c, 12d, 12e, 12f only if the new paddock is smaller or closer to the milking area 13.
Patent NZ-592786-A (NZ)
Title: Methods and compositions for treating complement-associated disorders using eculizumab
Inventor: ROTHER RUSSELL P
IPC: A61K39/00
Filed: 2009-11-10
Abstract: Disclosed are compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.
Patent NZ-597953-A (NZ)
Title: Methods and devices for uplink diversity transmission
Inventor: KAZMI MUHAMMAD
IPC: H04B7/04
Filed: 2010-10-04
Abstract: A method in a user equipment for controlling uplink transmit diversity operation and the user equipment (103) arranged to control uplink transmit diversity operation are disclosed. The user equipment comprises at least two uplink transmit antennas and the user equipment transmits using the at least two uplink transmit antennas. The user equipment comprises controller circuitry (107) arranged to receive a set of control signals in the downlink direction from a cellular network; controller circuitry (107) arranged to estimating a received signal quality for each control signal in the set of control signals; controller circuitry (107) arranged to determine, based on the received signal quality, which control signals that have been reliably received; controller circuitry (107) arranged to derive one or more parameters related to the uplink transmit diversity operation using a subset of control signals from the set of control signals, the subset only including control signals determined as reliably received; and controller circuitry (107) arranged to transmit in the uplink direction while applying the derived one or more parameters to control the uplink transmit diversity operation.
Patent NZ-598250-A (NZ)
Title: Cap with skirt and axial attachment means for attachment to similar caps
Inventor: TAMARINDO STEFANO
IPC: B65D41/02
Filed: 2012-02-16
Abstract: Cap1 for a container for liquid foods comprises attachment means suitable to mechanically attach the cap 1 in a releasable manner to at least one further similar cap. The attachment means comprises axial attachment means with the further cap which axially overlaps the previous cap, and comprises at least one axially projecting tooth 30. The tooth 30 is engageable with the skirt of the further overlapping cap.
Patent NZ-598493-A (NZ)
Title: Advanced fusion fuel
Inventor: GA CHARLES E
IPC: F03H1/00
Filed: 2010-09-17
Abstract: Disclosed herein is the use of an isotopically pure 11Boron Deuteride as a fuel for thermonuclear fusion reactions for power generation, preferably wherein in the power output is conveyed by alpha particles and neurons.
Patent NZ-600820-A (NZ)
Title: Heterodimer binding proteins and uses thereof
Inventor: TAN PHILIP
IPC: C07K16/46
Filed: 2010-12-29
Abstract: Disclosed is polypeptide heterodimer, comprising: (a) a first single chain polypeptide (SCP-I) comprising from one to four binding domains that specifically bind from one to four targets, a hinge (H-I), an immunoglobulin heterodimerisation domain (HD-I), and an immunoglobulin CH2 and CH3 domain of IgG1, IgG2, IgG3, IgG4, IgA1, IgA2, IgD, or any combination thereof (CH2CH3-I); and (b) a second single chain polypeptide (SCP-II) comprising from zero to four binding domains that specifically bind from zero to four targets, a hinge (H-II), an immunoglobulin heterodimerisation domain (HD-II), and an immunoglobulin CH2 and CH3 domain of IgG1, IgG2, IgG3, IgG4, IgA1, IgA2, IgD, or any combination thereof (CH2CH3-II); wherein (i) the immunoglobulin heterodimerisation domain of the first single chain polypeptide (HD-I) and the immunoglobulin heterodimerisation domain of the second single chain polypeptide (HD-II) preferentially associate with each other to form a polypeptide heterodimer comprised of the first single chain polypeptide (SCP-I) and the second single chain polypeptide (SCP-II), and (1) the immunoglobulin heterodimerisation domain of the first single chain polypeptide (HD-I) comprises a first immunoglobulin CH1 region, and the immunoglobulin heterodimerisation domain of the second single chain polypeptide (HD-II) comprises a first immunoglobulin CL region, or (2) the immunoglobulin heterodimerisation domain of the first single chain polypeptide (HD-I) comprises a first immunoglobulin CL region, and the immunoglobulin heterodimerisation domain of the second single chain polypeptide (HD-II) comprises a first immunoglobulin CH1 region; and (ii) wherein the first immunoglobulin CL region is an altered human immunoglobulin Cκ region with one or more amino acids of a wild type human Cκ region substituted at N29, N30, Q52, V55, T56, S68, or T70, provided that the polypeptide heterodimer comprises at least two binding domains (BD1 and BD2) that specifically bind at least two different targets. Also disclosed is the use of the above-described polypeptide heterodimer in the manufacture of a medicament for treating a B-cell associated disorder or disease in a patient, wherein the polypeptide heterodimer comprises a binding domain that specifically binds TCRα, TCRβ, CD3γ, CD3δ, CD3ε, and a second binding domain that specifically binds to CD19, CD20, CD79b or HLA-DR.
Patent NZ-604338-A (NZ)
Title: Detection of target nucleic acid sequences by pto cleavage and extension assay
Inventor: CHUN JONG YOON
IPC: C12Q1/68
Filed: 2012-01-11
Abstract: Disclosed is a method for detecting a target nucleic acid sequence from a DNA or a mixture of nucleic acids by a PTOCE (PTO Cleavage and Extension) assay, comprising: (a) hybridising the target nucleic acid sequence with an upstream oligonucleotide and a PTO (Probing and Tagging Oligonucleotide); wherein the upstream oligonucleotide comprises a hybridising nucleotide sequence complementary to the target nucleic acid sequence; the PTO comprises (i) a 3’-targeting portion comprising a hybridising nucleotide sequence complementary to the target nucleic acid sequence and (ii) a 5’-tagging portion comprising a nucleotide sequence non-complementary to the target nucleic acid sequence; wherein the 3’-targeting portion is hybridised with the target nucleic acid sequence and the 5’-tagging portion is not hybridised with the target nucleic acid sequence; the upstream oligonucleotide is located upstream of the PTO; (b) contacting the resultant of the step (a) to an enzyme having a 5’ nuclease activity under conditions for cleavage of the PTO; wherein the upstream oligonucleotide or its extended strand induces cleavage of the PTO by the enzyme having the 5’ nuclease activity such that the cleavage releases a fragment comprising the 5’-tagging portion or a part of the 5’-tagging portion of the PTO; (c) hybridising the fragment released from the PTO with a CTO (Capturing and Templating Oligonucleotide); wherein the CTO comprises in a 3’ to 5’ direction (i) a capturing portion comprising a nucleotide sequence complementary to the 5’- tagging portion or a part of the 5’-tagging portion of the PTO and (ii) a templating portion comprising a nucleotide sequence non-complementary to the 5’-tagging portion and the 3’-targeting portion of the PTO; wherein the fragment released from the PTO is hybridised with the capturing portion of the CTO; (d) performing an extension reaction using the resultant of the step (c) and a template-dependent nucleic acid polymerase; wherein the fragment hybridised with the capturing portion of the CTO is extended and an extended duplex is formed; wherein the extended duplex has a Tm value adjustable by (i) a sequence and/or length of the fragment, (ii) a sequence and/or length of the CTO or (iii) the sequence and/or length of the fragment and the sequence and/or length of the CTO; (e) melting the extended duplex over a range of temperatures to give a target signal indicative of the presence of the extended duplex; wherein the target signal is provided by (i) at least one label linked to the fragment and/or the CTO, (ii) a label incorporated into the extended duplex during the extension reaction, (iii) a label incorporated into the extended duplex during the extension reaction and a label linked to the fragment and/or the CTO, or (iv) an intercalating label; and (f) detecting the extended duplex by measuring the target signal; whereby the presence of the extended duplex indicates the presence of the target nucleic acid sequence
Patent NZ-606801-A (NZ)
Title: Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
Inventor: CHATTERJI ASHISH
IPC: A61K31/4164
Filed: 2011-08-08
Abstract: The disclosure relates to a family of pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof. The compositions form a layered pellet which contain the therapeutic active compound, a rate release controlling polymer and pH responding polymer (that is ionic and non-ionic polymers) polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The core of the therapeutic active compound contains an azole (either pyrazole or imidazole), a pyridine and an alkyne group. The compositions provide a pH-independent in vitro release profile with NMT 70 % in one hour, NMT 85 % in 4 hour, and NLT 80 % in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment- Resistant Depression (TRD) and Fragile X Syndrome.
Patent NZ-613951-A (NZ)
Title: On-line membership verification utilizing an associated organization certificate
Inventor: CAHN ROBERT S
IPC: H04L9/32
Filed: 2012-02-15
Abstract: Disclosed is a computer implemented method for verifying a membership certificate of a purported member of an identified organization. The membership certificate is represented as an icon on a purported member’s website. The computer implemented method comprises activating the membership certificate icon and retrieving the membership certificate linked to the icon. The membership certificate comprises a field identifying an organization that issued the membership certificate and a payload section including specific information pertaining to the purported member. The specific information is structured by specific fields. The method further comprises retrieves an organization certificate associated with the identified organization that creates the membership certificate. The organization certificate includes a predetermined set of information elements defining the membership. The predetermined set of information elements structured by fixed fields is defined by the identified organization. The method then comprises comparing the specific information structured by specific fields in the payload section of the membership certificate with the predetermined set of information elements within the organization certificate; and verifying the membership certificate if and only if the specific information structured by specific fields in the membership certificate matches the predetermined set of information elements structured by fixed fields within the organization certificate as defined by the identified organization.
Patent NZ-618225-A (NZ)
Title: System for generating a weld and method of controlling a welder with modification of voltage and wire feed speed based on a calculated welding output power
Inventor: LAMERT ROGER H
IPC: B23K9/10
Filed: 2012-05-25
Abstract: Disclosed is a system for generating a weld. The system comprises a power circuit (150) and a control circuit (152). The power circuit (150) generates the welding output power. The control circuit (152) is in communication with the power circuit (150). The control circuit (152) determines the computed power output and modifies the voltage and wire feed speed if the calculated welding output power exceeds a certain value. The voltage and wire feed speed can be reduced proportionally or according to a predefined relationship. The system can reduce the voltage and wire feed speed such that a momentary power excess is countered in a manner that mitigates oscillation or period variation of wire speed.
Patent NZ-621503-A (NZ)
Title: Hollow section structural member
Inventor: NICHOLAS ALEXANDER STEPHEN CLEMENTS
IPC: E04C3/32
Filed: 2014-02-20
Abstract: A hollow section structural member 10 suitable to form an outer wall of a concrete-filled column in a framework of a multi-storey building, the hollow section structural member comprising two or more steel plates 12, 14 that form different portions of the hollow section structural member, at least one of the steel plates being folded and with the steel plates being welded together and forming the hollow section structural member, and connectors fastened to a surface of one or more of the steel plates, and with at least one of the steel plates having one or more openings for (a) receiving a beam, (b) venting vapour from internally of the hollow section structural member, or (c) enabling drainage of water from internally of the member.