baber/WOPTO huggingface dataset:
Patent EP-3878475-A1 (EP)
Inventor: RODRIGUEZ-TANTY CHRYSLAINE
IPC: A61K49/18
Filed: 2019-05-13
Abstract: This invention is related to Chemistry and Physics applied to the field of Medicine and refers to the use of compounds with magnetic properties, which belong to the category of metal oxide nanoparticles, coated and conveniently functionalized, which are conjugated with naphthalene compounds related to agglomerates and β-amyloid plaques present in neurodegenerative diseases. These new nanoparticles (NPs) are used for the non-invasive detection of agglomerates and amyloid plaques using the Magnetic Resonance Imaging (MRI) technique. The nanoparticles described here cross the blood-brain barrier (BBB), without the use of any membrane-disrupting agent. Likewise, they bind with high affinity and specificity to the agglomerates and β-amytoid plaques, and are used as contrast agents in MRI for the early detection of Alzheimer's disease (AD). 
     The new nanoparticles, coated, functionalized and conjugated with the naphthalene derivatives, have general Formula  I; 
     
wherein: 
 R 1   : is an organic coating to the metal oxide core, of polymeric type, catechol derivatives and trialkoxyalkylaminosilane; 
 R 2   : -NHCO-alkylenyl-C(O)NH-alkylenyl-R 3 ; 
 R 3   : -COO-, -CO-, -NH, -O-, -S-, -NH-alkylenyl-NH-, -NR 4 -CSS-; 
 R 4   : -H, -CH 3 , -CH 2 -CH 3 , -CH 2 CH 2 CH 3 , and 
 M x O y   : iron oxide (Fe 3 O 4 /γFe 2 O 3 ), gadolinium oxide(III), manganese oxide(II) and copper(II) oxide; 
 
wherein the conjugated, functionalized and coated magnetic nanoparticle is capable of, when it is administered to a mammal, crossing the blood-brain barrier and specifically binding to the agglomerates and amyloid plaques present in brain tissue; 
wherein with this nanoparticle bound to the agglomerates and β-amyloid plaques in the brain tissue, hypo- or hyper-intense signals are observed in the region of interest through MRI. 
     The compounds of Formula  I  are capable of acting as positive (T1) and / or negative (T2) contrast agents for MRI for the early and non-invasive diagnosis of AD, through a hypo- or hyper-intense signal of the β-amytoid agglomerates or Aβ plaques. 
     In the NPs of Formula I, the metallic oxide magnetic core is coated with a functionalized polymeric layer that allows conjugation to naphthalene compounds, the preparation of which has been previously described in CU 2010/0204, EP 2 436 666 A20, P58243ZA00, US 9,764,047, CA 2789869C, PI 2012003534. 
     The covalent and stable bond between the two chemical units form, in the NPs, a carbon chain with a singular structure, which surprisingly facilitates the NPs passage through the BBB, without the use of a disrupting agent, what are not described in the current state-of-the-art. 
     These NPs unexpectedly enhance the affinity and selectivity properties of the naphthalene derivatives towards the Aβ agglomerates and β-plaques, they are stable molecules and do not show toxicity. We are not aware that the compounds presented in this invention have been previously reported.
Patent EP-3847086-A1 (EP)
Title: Anhängerbremssteuergerät sowie verfahren und software dafür und anhängerfahrzeug damit
Inventor: GLAVINIC ANDELKO
IPC: B60L15/42
Filed: 2019-08-09
Abstract: Die Erfindung betrifft ein Verfahren für ein Anhängerbremssteuergerät (42) eines Fahrzeuganhängers (16) mit einem elektrischen Antrieb (52), wobei das Verfahren das Empfangen (122) mindestens eines Beschleunigungsanforderungssignals (46) mit einer angeforderten positiven Beschleunigung (31) oder einer angeforderten negativen Beschleunigung (33) von einem Zugfahrzeug (12) und eines Statussignals (64) vom elektrischen Antrieb (52) des Fahrzeuganhängers (16) mit mindestens einer Statusvariablen (90) des elektrischen Antriebs (52) des Fahrzeuganhängers (16) mittels mindestens eines Eingangs (40, 68) und/oder mindestens einer Schnittstelle (86) des Anhängerbremssteuergeräts (42) umfasst. Ferner umfasst das Verfahren das Erzeugen (124) mindestens eines Bremsansteuersignals (50) für mindestens eine Reibbremse (22) des Fahrzeuganhängers (16) und eines Drehmomentanforderungssignals (62) für den elektrischen Antrieb (52) jeweils in Abhängigkeit des Beschleunigungsanforderungssignals (46) und des Statussignals (64) mit einer Steuerung (48) des Anhängerbremssteuergeräts (42) und das Ausgeben (126) des Bremsansteuersignals (50) und des Drehmomentanforderungssignals (62) mittels mindestens eines Ausgangs (66) oder einer Schnittstelle (86) des Anhängerbremssteuergeräts (42). Außerdem betrifft die Erfindung ein Computerprogrammprodukt zum Ausführen des Verfahrens, ein Anhängerbremssteuergerät (42), einen Fahrzeuganhänger (16) mit einem Anhängerbremssteuergerät (42) sowie die Verwendung eines Anhängerbremssteuergeräts (42) zum Steuern eines elektrischen Antriebs (52).
Patent EP-3757605-A1 (EP)
Inventor: YAMAMOTO KOJI
IPC: G01S7/484
Filed: 2019-02-07
Abstract: An electromagnetic wave irradiated by an irradiator (10) is incident on and reflected by a movable reflection unit (20). The control unit (30) controls the irradiator (10) and the movable reflection unit (20). A sensor (40) is disposed at a position through which the electromagnetic wave when an irradiation direction of the electromagnetic wave is moved in a first direction. Then, the control unit (30) executes the following processing in setting a movement range of the movable reflection unit (20). First, a detection value (first detection value) of the sensor (40) when light is irradiated at a first position Sa positioned ahead of the sensor (40) in the first direction is recognized. Next, a detection value (second detection value) of the sensor (40) when light is irradiated at a second position Sb positioned behind the sensor (40) in the first direction is recognized. Then, the movement range of the movable reflection unit (20) is set using the first detection value and the second detection value.
Patent EP-3763988-A1 (EP)
Inventor: MUNEDA TAKU
IPC: B32B15/08
Filed: 2019-03-04
Abstract: The present disclosure provides a wrapping material for vacuum thermal insulation materials, which comprises a thermally weldable film and a gas barrier film, and wherein: the gas barrier film comprises a base material and an aluminum metal film that is formed on one surface of the base material; and the aluminum metal film satisfies formula (1) and formula (2). (1): 1.0 <sup>∗</sup> 10<sup>-3</sup> ≤ (I<sub>A</sub>/I<sub>B</sub>) / T ≤ 3.5 <sup>∗</sup> 10<sup>-3</sup> (2): (A/B) / T ≥ 3.8 <sup>∗</sup> 10<sup>-3</sup> (In formula (1) and formula (2), I<sub>A</sub> represents the peak intensity (cps) of a diffraction peak that is positioned around 2θ = 38.5° in an X-ray diffraction measurement of the aluminum metal film with use of a CuKα ray; I<sub>B</sub> represents the peak intensity (cps) of a diffraction peak that is positioned around 2θ = 44.6° in an X-ray diffraction measurement of an aluminum metal foil with use of a CuKα ray; A represents the peak intensity (kcps) of elemental aluminum of the aluminum metal film as determined by X ray fluorescence analysis; B represents the peak intensity (kcps) of elemental aluminum of the aluminum metal foil as determined by X ray fluorescence analysis; and T represents the thickness (nm) of the aluminum metal film.
Patent EP-3761863-A1 (EP)
Inventor: HENNEMAND VINCENT
IPC: A61B5/00
Filed: 2019-03-04
Abstract: Systems and methods for generating a personalized cognitive treatment recommendation for an individual. The system includes one or more processors; and a memory to store processor-executable instructions. Upon execution of the instructions, the one or more processors receive parameters for at least one cognitive treatment tool; receive physiological data indicative of a condition of the individual, and/or clinical data associated with the individual; and generate the personalized cognitive treatment recommendation based on the physiological data and/or the clinical data. The recommendation includes a specification of (i) at least one first cognitive treatment tool, (ii) at least one second cognitive treatment tool different from the at least one first cognitive treatment tool, or (iii) both (i) and (ii). Optionally, the one or more processors receive performance data indicative of the individual's performance of at least one task associated with the at least one cognitive treatment tool of the recommendation.
Patent EP-3791235-A1 (EP)
Inventor: DE GRIMAUDET DE ROCHEBOUET FRANÇOIS
IPC: G01M15/12
Filed: 2019-09-12
Abstract: The present invention essentially relates to a method (200) for monitoring the operation of a machine that generates vibrations, the method (200) comprising a learning phase (F1) in which a knowledge base containing vibrational signatures representative of the operation of the machine is generated, and a monitoring phase (F2) in which the vibrations of the machine are compared to the knowledge base so as to detect an anomaly in the machine.
Patent EP-3768301-A1 (EP)
Inventor: ZACKS DAVID
IPC: A61K38/45
Filed: 2019-03-20
Abstract: L'invention concerne des compositions et des méthodes de prévention, de traitement ou d'amélioration d'une maladie ou d'un état induit par une inflammation et/ou médié par le complément chez un sujet, comprenant l'administration au sujet d'un inhibiteur Fas, son dérivé, un sel pharmaceutiquement acceptable de celui-ci, d'une thérapie génique codant pour l'inhibiteur Fas dans une quantité efficace pour inhiber la signalisation Fas.
Patent EP-3857197-A1 (EP)
Inventor: ELFERT GUNTHER
IPC: F16C41/00
Filed: 2019-09-19
Abstract: Es wird ein Wälzkörper (1) zur Verwendung in einem Wälzlager (100), mit einem Außenmantel (2) und einer Bohrung (3) vorgeschlagen, wobei die Bohrung (3) vorzugsweise entlang einer Mittelachse des Wälzkörpers (1) vorgesehen ist, wobei der Wälzkörper (1) wenigstens einen in der Bohrung (3) angeordneten Sensor (5) zur Belastungsmessung und ein Übertragungsmodul zur Übertragung der von dem Sensor (5) gemessenen Daten umfasst, wobei der Wälzkörper eine Energiequelle aufweist, wobei die Energiequelle zur Bereitstellung der zum Betrieb des Sensors (5) und/oder des Übertragungsmoduls benötigten Energie vorgesehen ist, dadurch gekennzeichnet, dass der Sensor (5) ein induktiv messender Sensor ist. Weiterhin werden ein Wälzlager und ein Verfahren zur Belastungsmessung vorgeschlagen.
Patent EP-3778518-A1 (EP)
Inventor: NOHARA ATSUSHI
IPC: C03C27/12
Filed: 2019-03-29
Abstract: Provided is an interlayer film for laminated glass capable of enhancing the heat shielding property, suppressing aggregation of silver, and capable of keeping the high heat shielding property. The interlayer film for laminated glass according to the present invention has an infrared reflective layer, and a first resin layer containing a thermoplastic resin, the first resin layer is arranged on a first surface side of the infrared reflective layer, the infrared reflective layer includes a silver layer, and a half band width of peak in (111) diffraction plane is 1.3 or less, or a half band width of peak in (200) diffraction plane is 2.0 or less in In-Plane XRD measurement of the silver layer.
Patent EP-3857066-A1 (EP)
Inventor: BROUCKE STIJN
IPC: F04C23/00
Filed: 2019-09-24
Abstract: An oil-injected multi-stage compressor system,that comprises at least a low-pressure stage compressor element (2) with an inlet (4a) and an outlet (5a) and a high-pressure stage compressor element (3) with an inlet (4b) and an outlet (5b), whereby the outlet (5a) of the low-pressure stage compressor element (2) is connected to the inlet (4b) of the high- pressure stage compressor element (3) through a pipeline (6), characterized in that the compressor elements (2, 3 ) are provided with their own drive in the form,of an electric motor (2a, 3a), whereby the compressor elements (2, 3) are connected to the electric motor (2a, 3a) either directly or through a gearbox and that an intercooler (9) is provided in the aforementioned pipeline (6) between the low-pressure stage compressor element (2) and the high-pressure stage compressor element (3).
Patent EP-3867943-A1 (EP)
Inventor: COVEY THOMAS R
IPC: G01N1/40
Filed: 2019-10-17
Abstract: L'appareil, les systèmes et les procédés décrits ici servent à l'échantillonnage dans des systèmes de spectrométrie de masse. En particulier, les procédés décrits comprennent la fonctionnalisation d'une surface externe d'un élément d'échantillonnage allongé, par exemple, une tige de verre ou de silice avec un polypeptide qui se lie préférentiellement à un analyte. L'élément d'échantillonnage allongé s'étend et est conçu pour être inséré dans une interface d'échantillonnage à port ouvert d'un système de spectrométrie de masse pour la détection et l'analyse de l'analyte.
Patent EP-3864335-A1 (EP)
Inventor: ALLIDIERES LAURENT
IPC: F17C5/02
Filed: 2019-09-24
Abstract: The invention relates to a method for storing and distributing liquefied hydrogen using a facility (1) that comprises a store (4) of liquid hydrogen at a predetermined storage pressure, a source (2) of hydrogen gas, a liquefier (3) comprising an inlet connected to the source (2) and an outlet connected to the liquid hydrogen store (4), the store (4) comprising a pipe (10) for drawing liquid, comprising one end connected to the liquid hydrogen store (4) and one end intended for being connected to at least one mobile tank (8), the method comprising a step of liquefying hydrogen gas supplied by the source (2) and a step of transferring the liquefied hydrogen into the store (4), characterized in that the hydrogen liquefied by the liquefier (3) and transferred into the store (4) has a temperature lower than the bubble temperature of hydrogen at the storage pressure.
Patent EP-3863534-A1 (EP)
Inventor: DRAKE RONALD A
IPC: A61N1/375
Filed: 2019-10-09
Abstract: An example implantable medical device (IMD) retrieval system may include an elongate outer tubular member including a longitudinally extending lumen terminating in a distal cup that is configured to receive the IMD; and a retrieval assembly including a retrieval member that includes an elongate member terminating in at least one snare that is moveable between an expanded configuration and a contracted configuration; and a fixed-curve catheter that includes a resilient material forming a distal curve and defining a lumen in which the retrieval member extends in sliding engagement, where the fixed-curve catheter extends in sliding engagement within the lumen of the elongate outer tubular member.
Patent EP-3788630-A1 (EP)
Inventor: EADES STEPHEN
IPC: A61B5/0205
Filed: 2019-04-30
Abstract: A personal management device includes a programmable scheduler to permit a user's schedule for a designated period to be recorded. A clock function provides prompts for each scheduled activity at an appropriate time. The device also includes a monitor of biological indicators and upon attainment of threshold levels indicative of onset of anxiety, interrupts the scheduled activity to implement a coping strategy.
Patent EP-3877275-A1 (EP)
Title: Packung für produkte der zigarettenindustrie und verfahren sowie vorrichtung zur herstellung derselben
Inventor: SCHNEIDER CHRISTOPH
IPC: B65B19/22
Filed: 2019-11-06
Abstract: Die Erfindung betrifft eine Packung für Produkte (11) der Zigarettenindustrie, mit einem Schachtelteil (22) zur Aufnahme eines Packungsinhalts (29) und mit einem Deckel (23) zum Verschließen des Schachtelteils (22), wobei Deckel (23) und Schachtelteil (22) mit jeweiligen Schließkanten bei geschlossener Packung (10) aneinander anliegen. Die Erfindung ist dadurch gekennzeichnet, dass Deckel (23) und Schachtelteil (22) im Bereich wenigstens einer Schließkante temporär, nämlich bis zum erstmaligen Öffnen der Packung (10), miteinander verbunden sind.
Patent EP-3873779-A1 (EP)
Inventor: FRANC ALEXANDRE
IPC: F21W103/35
Filed: 2019-10-25
Abstract: The invention relates to a lighting device (1) for a motor vehicle, comprising: - a housing (10); - a noise-reducing material (11); characterised in that: - the noise-reducing material (11) is partially disposed inside the housing (10) and is in contact with the housing (10); - the housing (10) has at least one hole (100) and the noise-reducing material (11) is configured to pass through the at least one hole (100) and extends projecting from the at least one hole (100) to the outside of the housing (10).
Patent EP-3796454-A1 (EP)
Inventor: YURA YUKINOBU
IPC: H01M50/443
Filed: 2019-05-14
Abstract: Provided is a lithium secondary battery with high discharge capacity, as expected, and excellent charge/discharge cycle performance. The lithium secondary battery includes a positive electrode layer composed of a lithium complex oxide sintered body, a negative electrode layer composed of a titanium-containing sintered body, a ceramic separator interposed between the positive electrode layer and the negative electrode layer, an electrolyte with which at least the ceramic separator is impregnated, and an exterior body comprising a closed space, the closed space accommodating the positive electrode layer, the negative electrode layer, the ceramic separator, and the electrolyte. The positive electrode layer, the ceramic separator, and the negative electrode layer form one integrated sintered plate as a whole, whereby the positive electrode layer, the ceramic separator, and the negative electrode layer are bonded together.
Patent EP-3805927-A1 (EP)
Title: Maintenance operation assistance system
Inventor: KONO TOSHIAKI
IPC: G06F11/22
Filed: 2019-05-09
Abstract: Provided is a maintenance operation assistance system comprising: a failure knowledge database wherein failure knowledge data is recorded; a failure knowledge coupling unit for reconstructing partial failure knowledge data into failure knowledge data; and an inspection procedure generation unit for presenting an inspection procedure using the reconstructed failure knowledge data. The failure knowledge coupling unit evaluates and adjusts the relatedness of nodes among different instances of partial failure knowledge data, and connects the different instances of partial failure knowledge data. On the basis of the reconstructed failure knowledge data, the inspection procedure generation unit sets priorities for when presenting the inspection procedure, and presents the inspection procedure to a diagnostic interface unit in accordance with the priorities.
Patent EP-3796878-A1 (EP)
Inventor: WAITKUS TIM
IPC: A61F5/44
Filed: 2019-05-13
Abstract: A urine-sampling system for aseptic urine sampling includes a catheter assembly and a sampling-port access device. The catheter assembly includes a urinary catheter, drainage tubing, and a connector fluidly connecting the urinary catheter to the drainage tubing. The connector includes a urine-sampling port. The sampling-port access device includes a tip at an end of a barrel configured to fluidly connect the sampling-port access device to the urine-sampling port of the catheter assembly. Each of the tip of the sampling-port access device and the urine-sampling port has a complementary fastening means for- fastening to the other of the tip of the sampling-port access device and the urine-sampling port. Each of the complementary fastening means ensures proper mating of the tip of the sampling-port access device and the urine-sampling port for aseptic urine sampling. In addition to various urine-sampling systems such as the foregoing, methods of use are also disclosed.
Patent EP-3894800-A1 (EP)
Inventor: GRUNWALD SASCHA
IPC: G01F1/66
Filed: 2019-11-21
Abstract: L'invention concerne un ensemble de transducteurs ultrasonores (10) d'un point de mesure de débit à ultrasons du type "clamp-on" (10), comprenant plusieurs transducteurs ultrasonores du type "clamp-on" (20), ledit ensemble pouvant être utilisé sur des tubes de mesure (2) de diamètres différents, sans qu'un réajustage des transducteurs ultrasonores dudit ensemble de transducteurs ultrasonores soit nécessaire.
Patent EP-3804046-A1 (EP)
Title: Method of preventing moisture intrusion through the cable exit of an enclosure
Inventor: PRICE DANIEL SCOTT
IPC: H01R13/40
Filed: 2019-05-31
Abstract: Systems, devices, and methods including: a cable (102); a housing (120, 122, 304, 306) having a tapered exit hole (110) connected to an internal volume (116); a tapered seal (112) having a tapered outer surface (134) and an inner aperture (128), where the inner aperture of the tapered seal receives the cable; an encapsulant (118) disposed in the internal volume and about one or more wires of the cable; and a compression cap (114) placed over the tapered seal and about a flange (138) of the housing to compress the tapered seal into the tapered exit hole; where compression from the compression cap forces the encapsulant up inside the cable and around the one or more wires of the cable, and where curing of the encapsulant seals the cable from moisture incursion.
Patent EP-3880738-A1 (EP)
Inventor: LUE CHING-TAI
IPC: C08L23/08
Filed: 2019-11-13
Abstract: Provided herein are polyethylene films made of the polyethylene blends having improved properties, particularly in Elmendorf tear and puncture resistance. The polyethylene blends include two primary polyethylene blends.
Patent EP-3807994-A1 (EP)
Inventor: GEWAX LAWRENCE JAMES
IPC: H03K17/62
Filed: 2019-06-07
Abstract: A method (400) of operating the IC chip in response to an event trigger is provided. The method includes responsive to the event trigger, coupling (405) a pin to a source of constant current to charge an external capacitor coupled to the pin and monitoring (410) a capacitor voltage on the pin. If the magnitude of the capacitor voltage is greater than a rising threshold, detection (415) of a falling threshold is enabled. If the magnitude of the capacitor voltage is greater than a voltage threshold, a first response is triggered (420) and the pin is coupled (420) to the lower rail to discharge the external capacitor. If detection of the falling threshold is enabled and the magnitude of the capacitor voltage is less than the falling threshold, the first response is also triggered (425).
Patent EP-3809520-A1 (EP)
Title: Cavity filter and connecting structure included therein
Inventor: PARK NAM SHIN
IPC: H01P1/04
Filed: 2019-06-12
Abstract: The present invention relates to a cavity filter including: an RF signal connecting portion spaced apart, by a predetermined distance, from an outer member having an electrode pad provided on a surface thereof; and a terminal portion configured to electrically connect the electrode pad of the outer member and the RF signal connecting portion so as to absorb assembly tolerance existing at the predetermined distance and to prevent disconnection of the electric flow between the electrode pad and the RF signal connecting portion, wherein a part of the terminal portion, positioned between the electrode pad and the RF signal connecting portion, is elastically deformed to absorb assembly tolerance existing in a terminal insertion port. Therefore, the cavity filter can efficiently absorb assembly tolerance which occurs through assembly design, and prevent disconnection of an electric flow, thereby preventing degradation in performance of an antenna device.
Patent EP-3812267-A1 (EP)
Title: Control of formation flying and communication area, for example, of aircraft providing radio communication service
Inventor: MIYAKAWA JUNICHI
IPC: H04W84/06
Filed: 2019-06-13
Abstract: A control device is provided which forms a communication area on a ground to control an aircraft having an antenna for providing a radio communication service to a user terminal in the communication area. The control device includes a control unit that makes a plurality of aircrafts fly in formation, and controls the plurality of aircrafts such that the communication area of each of the plurality of aircrafts moves while covering a part of a preset target area and the entire target area is covered by a plurality of the communication areas of the plurality of aircrafts.