baber/WOPTO huggingface dataset:
Patent NZ-543849-A (NZ)
Title: Improvements in grass endophytes
Inventor: TAPPER BRIAN ANTHONY
IPC: A01H5/00
Filed: 2004-06-03
Abstract: Disclosed is a method of increasing the resistance of a grass plant to biotic and abiotic stresses. The method comprises the step of elevating the level of janthitrem epoxide compounds in the host grass to levels that confer resistance by inoculating the grass with at least one endophyte from Neotyphodium lolii species characterised by having a B10 allele size of approximately 160bp-161bp and a B11 allele size of approximately 132 bp.
Patent NZ-544472-A (NZ)
Title: Compounds and therapeutical use thereof
Inventor: CAI SUI XIONG
IPC: C07D239/95
Filed: 2004-07-06
Abstract: Provided is N4-(4-methoxy-phenyl)-N4-methyl-quinazoline-2,4-diamine and related specified 4-arylamino-quinazolines. Also provided is their use in the manufacture of medicaments to treat neoplasia or cancer, either alone or in combination with other drugs.
Patent NZ-545000-A (NZ)
Title: Genome mapping of functional DNA elements and cellular proteins
Inventor: FU XIANG-DONG
IPC: C12Q1/68
Filed: 2004-07-02
Abstract: Provided is an in vitro method, termed ChIp-DASL, to examine the binding of proteins to DNA, in particular to regulatory regions, across a genome or a portion thereof, e.g. a chromosome. The method steps comprise: a) immunoprecipitating a polynucleotide associated with a polypeptide to obtain an enriched polynucleotide preparation; b) disassociating the polynucleotide and polypeptide in the enriched preparation; c) contacting the polynucleotide with a primer pair under conditions whereby the primer pair hybridizes to the polynucleotide to form a first hybridization complex, each primer comprising at least two portions, a first portion comprising a target specific oligonucleotide that is capable of hybridizing to a target polynucleotide in the enriched preparation, and a second portion comprising a universal primer landing site, the two primers being specific for an upstream and downstream segment of the target polynucleotide, wherein the universal landing sites are not the same; d) contacting the first hybridization complex with a ligase under conditions whereby primer pairs hybridized to the polynucleotide are ligated to form a ligated probe; e) amplifying the ligated probe with universal primers to generate an amplified-labeled product; f) contacting the amplified-labeled product with an array of oligonucleotides under conditions whereby the ligated probe hybridizes to a complementary oligonucleotide in the array to form assay complexes; and g) detecting the assay complexes, wherein the presence of complexes is indicative of DNA that binds the immunoprecipitated polypeptide.
Patent NZ-547725-A (NZ)
Title: Discharge device with a metered dose valve
Inventor: DUNNE STEPHEN TERENCE
IPC: G01F11/28
Filed: 2004-12-03
Abstract: A discharge device with a metered dose valve is proposed. The metered dose valve comprises an inlet valve, a metering chamber and an outlet valve. In order to allow discharge of fluid from the metering chamber in multiple steps, a user can depress and release an actuation member multiple times in a selected discharge state wherein refill of the metering chamber with new liquid is prevented.
Patent NZ-550044-A (NZ)
Title: Cancerous disease modifying antibodies
Inventor: YOUNG DAVID S F
IPC: A61K39/395
Filed: 2005-03-29
Abstract: Provided is a specified monoclonal antibody which binds to Laminin Receptor I Precursor (37LRP). Further provided are binding assays using the antibody, methods of diagnosis using the same to determine the presence of cancerous cells in a tissue sample and use in the manufacture of a medicament for the treatment of human tumours.
Patent NZ-553330-A (NZ)
Title: Non-manual method for isolating embryos from monocot seeds and an apparatus for preparing multiple corn embryos
Inventor: ADAMS WHITNEY
IPC: C12N5/04
Filed: 2005-06-01
Abstract: Disclosed is a method of providing monocot embryos that are suitable for genetic transformation or tissue culture, the method comprises applying a non-manual force to monocot seeds that have an opening in the pericarp, the non-manual force is sufficient to extract the immature embryos from the seed. Also disclosed is an apparatus for preparing multiple corn embryos, the apparatus comprises at least one aperture for guiding a fluid stream which contacts kernels on said corn ear and extracts the embryos.
Patent NZ-554371-A (NZ)
Title: Process for producing mycophenolic acid using penicillium arenicola BICC7673
Inventor: PRABHU SUREKHA
Filed: 2004-10-05
Abstract: Disclosed is a biologically pure culture of the fungus, Penicillium arenicola BICC 7673. Further disclosed is the manufacture of mycophenolic acid by fermentation under optimal fermentation parameters using such.
Patent NZ-561731-A (NZ)
Title: Shirred elastic sheet material
Inventor: SLEIGHT GREG W
IPC: B65F1/00
Filed: 2003-09-19
Abstract: A retaining element for use with elastic sheet material is disclosed. In one form, the sheet material can be provided as a bag (100) having first and second side walls (102,104). The retaining element can be in the form of an elastic strip attached to one of the side walls. The retaining strip (120) can comprise a heat-unstable activatable material such that it can be applied to the bag in a deadened condition wherein the strip is set and subsequently heated to transition to an activated condition wherein the retaining element is elasticized to provide an elasticized article which can have a shirred appearance. The retaining element can have various configurations and can be activated by various methods.
Patent NZ-573137-A (NZ)
Title: Process for the synthesis of ibandronate sodium
Inventor: RAO DHARAMARAJ RAMCHANDRA
IPC: C07F9/38
Filed: 2007-06-22
Abstract: Disclosed is a process for the synthesis of ibandronate sodium of formula (I) comprising the steps of: (i) preparing 3-[N-(methylpentyl)amino]propionic acid of formula (III) by: (a) N-alkylating N-benzyl methylamine to form an N-alkylated intermediate (b) debenzylating the N-alkylated intermediate in presence of catalyst to form a secondary amine; (c) N-alkylating the secondary amine to obtain methyl 3-[N-(methylpentyl)amino]propionate of formula (IV) and; (d) hydrolysing methyl 3-[N-(methylpentyl)amino]propionate of formula (IV) to obtain 3-[N-(methylpentyl) amino]propionic acid of formula (III); (ii) reacting 3-[N-(methylpentyl)amino]propionic acid (III) with phosphorus acid, halophosphorus compound in an organic solvent selected from toluene, chlorobenzene, xylene, methane sulphonic acid, benzene sulphonic acid, ethylene dichloride, tetrahydrofuran, tetrachloroethane, dioxane, at a temperature of 50 degrees C to 100 degrees C; (iii) removing solvent followed by reflux in water and addition of sodium hydroxide; and (iv) precipitating ibandronate sodium of formula (I) using an organic solvent without the isolation of ibandronic acid.
Patent NZ-577857-A (NZ)
Title: Use of abscisic acid to alter sensory characteristics of red grapes and wine
Inventor: VENBURG GREGORY D
IPC: A01G17/02
Filed: 2008-01-30
Abstract: Disclosed is the use of S-abscisic acid (S-ABA) to modify sensory characteristics such as aroma, bouquet, flavor, mouthfeel, astringency, balance, complexity or finish of red grapes and red wine.
Patent NZ-578288-A (NZ)
Title: Electrical machine stator assembly with split toroidal core
Inventor: GERMANN TIMOTHY SCOTT
IPC: H02K1/06
Filed: 2010-05-07
Abstract: Disclosed is a method of assembling an electrical machine stator with multiple winding parts. The method includes providing at least two core portions (101) which can be assembled into a toroidal core. The core is configured to limit engagement of the core portions with each other and limit movement in a radial direction with respect to the axis of the core. Toroidal winding parts are mounted about each core portion. The core portions are assembled by movement in a plane normal to the machines rotational axis. When assembled, the joints (106) of the core portions fall equally in each phase of the winding parts. This is done such that the sum of the circumferential lengths of the configurations will be the same for any 180 electrical degrees of the stator, and that sum is a multiple (including one) of 180 electrical degrees.
Patent NZ-578800-A (NZ)
Title: Mechanical plug and method for using the same
Inventor: HEMMINGER MATTHEW
IPC: F16B13/04
Filed: 2008-01-31
Abstract: Disclosed is a mechanical plug for sealing a bore having a fixed diameter. The plug includes a cylindrically shaped resilient sleeve having a first end and a second end and a bolt having a first end and a second end that extends through the sleeve to combine the sleeve's first and second ends. The bolt includes a flange on its first end and a fastener which is movable relative to the bolt on its second end. Moving the fastener axially along the bolt towards the flange exerts a compressive force on the resilient sleeve that radially expands the resilient sleeve from a first diameter in which the plug can be inserted into the bore to a second diameter that is larger than the first diameter and approximates the diameter of the bore to seal the bore. The first end and the second end of the sleeve each have an inwardly tapered portion that facilitates the sleeve to radially expand from the first diameter to the second diameter without deforming the sleeve.
Patent NZ-582153-A (NZ)
Title: Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators
Inventor: SIENDT HERVE
IPC: A61P15/00
Filed: 2008-07-18
Abstract: The disclosure relates to substituted heteroarylpiperidine derivative (I) as melanocortin-4 receptor modulators. Depending on the structure and the stereochemistry these compounds of formula (I) are either selective agonists or selective antagonists of the human melanocortin-4 receptor (MC- 4R). These agonists can be used for the treatment of diseases and disorders where the regulation of the MC- 4R is involved, particularly disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, amyotrophic lateral sclerosis (ALS), anxiety and depression.
Patent NZ-583317-A (NZ)
Title: Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof as grehiln receptor antagonists
Inventor: BARONI MARCO
IPC: C07D401/12
Filed: 2008-08-14
Abstract: Provided is an indol-2-one compound disubstituted in the 3-positin of formula (I) where R1-5, X, Y, Ar and n are defined as in claim 1. The compound is an antagonist towards the ghrelin receptor and can be used for treating obesity, diabetes, appetite disorders and obesity.
Patent NZ-584714-A (NZ)
Title: Detector for fire hazard with perpendicular circuit board
Inventor: PERCY DAVID ROBERT
IPC: G08B17/00
Filed: 2010-04-16
Abstract: Disclosed is a fire hazard detector assembly. The assembly comprises of a sensor (30) for sensing a fire hazard condition, a circuit board (50), a shield (90) for protecting the circuit board, and a housing (10) for the sensor, circuit board, and shield. The housing has a substantially planar surface (11) for locating against a surface when the assembly is in use. The housing also has first support means (13) for supporting the circuit board perpendicular to the planar surface. The housing further comprises second support means for supporting the shield.
Patent NZ-598179-A (NZ)
Title: Medical implant comprising an iodine impregnated porous metallic surface layer on a metal substrate
Inventor: TAKAYA MATSUFUMI
IPC: A61L27/00
Filed: 2009-08-25
Abstract: 598179 Disclosed are metallic medical supplies using a metallic material as a base material (such as a pure metal selected from the group consisting of titanium and cobalt or an alloy selected from the group consisting of a titanium alloy, a cobalt alloy, stainless steel and a cobalt- chromium alloy), the medical supplies comprising a film (such as a metal oxide film coating) having micropores and/or micro unevennesses on the surface of the base material, where in the micropores and/or micro unevennesses are impregnated with iodine or iodine compounds (such as polyvinyl pyrrolidone iodine, ?-cyclodextrin iodine or silver iodide), and where in the film comprises the micropores and/or micro unevennesses having a density of at least 5 x 104/mm2 or more.
Patent NZ-599309-A (NZ)
Title: Palm activated drug delivery device
Inventor: OLSON LORIN P
IPC: A61M5/50
Filed: 2010-10-15
Abstract: A device (200) for administering medication is disclosed. The device comprises a multi-part housing holding a syringe. The syringe is supported by a lower housing (202) and the plunger of the syringe is carried by and upper housing (205). Movement of the upper housing (205) towards the lower housing (202) results in the medication being administered. Once the dose has been administered the upper housing (205) covers a middle housing (201) to indicate that the injection is complete.
Patent NZ-602612-A (NZ)
Title: Novel benzamide derivatives
Inventor: SUNG HYUN-JUNG
IPC: A61K31/435
Filed: 2011-04-18
Abstract: Disclosed herein are benzamide piperidine compounds of general formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. The compounds are intended for use as 5-HT4 receptor agonists and as such are useful in the treatment of gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer’s disease, cognitive impairment, emesis, migraine, neurological disease, pain, cardiovascular disorder, cardiac failure, cardiac arrhythmia, diabetes or apnea syndrome. Examples of particularly preferred compounds include: N-((1-(3-(1,2,4-triazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide, N-((1-(3-(tetrazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide, N-((1-(3-(2-methylimidazol-l-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide, N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide.
Patent NZ-603292-A (NZ)
Title: Anti-cmet antibody
Inventor: GOETSCH LILIANE
IPC: C07K16/46
Filed: 2009-12-02
Abstract: Disclosed is a monoclonal antibody, or a functional fragment or derivative thereof, capable to inhibit the c-Met dimerization, said antibody comprising a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3 with the amino acid sequences SEQ ID Nos. 1, 2 and 3, respectively; and a light chain comprising CDR-L1, CDR-L2 and CDR,-L3 with the amino acid sequences SEQ ID Nos. 5, 6 and 7, respectively, wherein said antibody consists of a chimeric, human or humanized antibody and in that it also comprises a hinge region comprising the amino acid sequence SEQ ID No. 21.
Patent NZ-610468-A (NZ)
Title: Piperidinone carboxamide azaindane cgrp receptor antagonists
Inventor: BELL IAN M
IPC: C07D471/10
Filed: 2011-11-10
Abstract: Disclosed are spiro condensed piperidinone azaindane pyrrolo pyridine carboxamide derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. An example of such a compound is (6S)-N-[(3S,5S,6R)-6-Methyl-5-(2-methylphenyl)-2-oxo-1-(2,2,2-trifluoroethyI)piperidin-3-yl]-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo [2,3-b]pyridine]-3-carboxamide. Also disclosed is the use of said compounds in the manufacture of a medicament for the prevention or treatment of diseases in which CGRP is involved, for example migraines.
Patent NZ-614019-A (NZ)
Title: System for dosing fluid
Inventor: MITCHELL GRANT SIDNEY
IPC: C02F5/08
Filed: 2012-01-24
Abstract: A system for dosing a stream of fluid with at least one active substance is disclosed. The system comprises a housing which defines a chamber having an inlet (13) and an outlet (14) to enable the flow of fluid through the chamber. A block containing the active substance is placed in the chamber that has a body with an outer surface and a passage there through defining an inner surface. The block is positioned within the housing chamber in an operative position between the inlet and the outlet so that in use fluid flows over the inner and outer surfaces of the block to dissolve and/or erode the block. the block consists of a solid carrier for carrying the active substance(s). The active substance(s) are evenly distributed throughout the solid carrier matrix. The active substance(s) in the block may consist of surfactants for fire fighting applications, detergents for cleaning applications or fertilisers, pesticides, insecticides or herbicides for agricultural or gardening applications or any other one or more active ingredients as desired. The one or more active substances may also comprise a foam stabiliser(s) and may also comprise a corrosion inhibitor(s). A suitable solid carrier is polyethylene glycol having an average molecular weight of between 1000 and 8000MW.
Patent NZ-625712-A (NZ)
Title: An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
Inventor: SIEGEL CRAIG
IPC: C07D405/06
Filed: 2010-11-24
Abstract: A compound represented by the structural formula I (GENZ 112638, eliglustat tartrate), which may be used in pharmaceutical applications, is disclosed. Particular single crystalline forms of the compund are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline forms of the compound, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases such as Gaucher disease and Fabry disease, are also discussed. Pharmaceutical compositions are also described.
Patent NZ-702093-A (NZ)
Title: Methods of lowering proprotein convertase subtilisin/kexin type 9 (pcsk9)
Inventor: MILNE JILL C
IPC: C07D401/12
Filed: 2013-05-24
Abstract: The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acids derivatives such as a compound of the Formula VI or a pharmaceutically acceptable salt, hydrate, enantiomer or stereoisomer thereof and new methods for treating or preventing metabolic disease comprising the administration of an effective amount of a fatty acid derivative such as a compound of the Formula VI. The present invention is also directed to fatty acid bioactive derivatives such as a compound of the Formula VI and their use in the treatment of metabolic diseases.
Patent NZ-707930-A (NZ)
Title: Dual inhibitors of met and vegf for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
Inventor: SMITH DAVID
IPC: C07D215/20
Filed: 2011-09-26
Abstract: The disclosure relates to methods for treating bone cancer, prostate cancer or bone cancer associated with prostate cancer, comprising administering a compound that dually modulates MET and VEGF. In particular, the methods are for treating castration-resistant prostate cancer (CRPC) and osteoblastic bone metastases and centres. The compound (compound I - cabozantinib) contains a quinolone, dicarboxamide and a cyclopropane functional groups.
Patent NZ-708077-A (NZ)
Title: Advanced blow-out preventer
Inventor: LEVETT BRYCE
IPC: E21B33/06
Filed: 2013-10-23
Abstract: Embodiments of the present advanced blowout preventers are for controlling flow through a wellbore, thereby providing well management, well containment, and blowout suppression. One such advanced blowout preventer includes an arrester section and a shear section. The arrester section includes a number of arrester rings that are shaped to extend downwardly. The shape of the arrester rings allows the force of fluid flowing out of the well to assist in closing the rings. The arrester rings can cooperate to significantly reduce fluid flow in the annulus between a section of drill pipe and the blowout preventer. The shear section is configured to engage and shear a section of pipe using induction. The arrester section comprises an arrester comprising blades that are movable relative to the bore between an open position and a closed position in which flow through the bore is more restricted than when the blades are in the open position. For each blade, when the blade is in the closed position, the blade: extends farther inwardly than when the blade is in the open position; overlaps an adjacent one of the blades; and when the arrester section is coupled to a wellhead, extending extends in a direction that is inwardly and downwardly toward the wellhead. At least a majority of the surface area of the blade is exposed to a fluid when the fluid flows through the bore. The arrester section also comprises motor connected to the arrester and configured to move the blades between the open and closed positions in response to the motor being and as the motor is energized.
Patent NZ-714673-A (NZ)
Title: Method and system for treating water used for industrial purposes
Inventor: FISCHMANN TORRES FERNANDO BENJAMIN
IPC: C02F1/68
Filed: 2011-09-12
Abstract: System for treating water used for industrial purposes at low cost that eliminates suspended solids in the water by filtering a small fraction of the total volume of water, the system comprising: ‐ at least one containing means having a volume of at least 15,000m3, which comprises a receiving means for settled particles, that is fixed to the bottom of said containing means, with a feeding line for water and an outlet lines for downstream processes; ‐ at least one coordination means is capable of receiving information, processing that information, and , that activates the necessary processes to adjust parameters of the water within their predetermined limits; ‐ at least one chemical application means, which is activated by said at least one coordination means ‐ at least one mobile suction means, for suctioning the water containing the settled particles, and which has a propelling means allowing it to move through the bottom of the containing means; ‐ at least one filtration means that filters the water flow containing the settled particles with at least one collecting line coupling it with the mobile suction means; ‐ at least one return line from the at least one filtration means to said at least one containing means;
Patent NZ-729148-A (NZ)
Title: Antibodies that bind il-4 and/or il-13 and their uses
Inventor: RAO ERCOLE
IPC: A61P37/08
Filed: 2008-10-14
Abstract: Disclosed is an isolated humanized antibody or antibody fragment thereof that specifically binds IL-13, wherein the antibody or antibody fragment thereof comprises a light chain variable domain comprising CDRs having the amino acid sequences RASESVDSYGQSYMH (SEQ ID NO: 8), LASNLES (SEQ ID NO: 9), and QQNAEDSRT (SEQ ID NO: 10) and a heavy chain variable domain comprising CDRs having the amino acid sequences GFSLTDSSIN (SEQ ID NO: 11), DGRID (SEQ ID NO: 12), and DGYFPYAMDF (SEQ ID NO: 13). Also disclosed is an isolated humanized antibody or antibody fragment thereof that specifically binds IL-4, wherein the antibody or antibody fragment thereof comprises a light chain variable domain comprising CDRs having the amino acid sequences HASQNIDVWLS (SEQ ID NO: 14), KASNLHTG (SEQ ID NO: 15), and QQAHSYPFT (SEQ ID NO: 16) and a heavy chain variable domain comprising CDRs having the amino acid sequences GYSFTSYWIH (SEQ ID NO: 17), IDPSDGETR (SEQ ID NO: 18) and LKEYGNYDSFYFDV (SEQ ID NO: 19) or the amino acid sequences GYSFTSYWIH (SEQ ID NO: 17), IDASDGETR (SEQ ID NO: 21), and LKEYGNYDSFYFDV (SEQ ID NO: 19).