Patent SG-11201810485S-A (SG)
Title: Substituted carbonucleoside derivatives useful as anticancer agents
Inventor: KUMPF ROBERT ARNOLD
IPC: C07D487/04
Filed: 2017-06-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2017/212385 Al 14 December 2017 (14.12.2017) W I PO I PCT (51) International Patent Classification: 12229 Carmel Vista Road, #253, San Diego, CA 92130 C07D 239/42 (2006.01) C07D 519/00 (2006.01) (US). RUE Eugene Yuanjin; 11254 Caminito Corriente, CO7D 239/84 (2006.01) A61K 31/519 (2006.01) San Diego, CA 92128 (US). TATLOCK, John Howard; CO7D 251/18 (2006.01) A61K 31/505 (2006.01) 10220 Camino San Thomas, San Diego, CA 92127 (US). CO7D 487/04 (2006.01) A61K 31/53 (2006.01) TRAN-DUBE, Michelle Bich; 525 11th Avenue, Unit CO7D 491/048 (2006.01) A61P 35/00 (2006.01) 1510, San Diego, CA 92101 (US). WYTHES, Martin (21) International Application Number: James; 756 North Granados Avenue, Solana Beach, CA PCT/IB2017/053295 92075 (US). (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd (22) International Filing Date: Street, MS 235/9/S20, New York, NY 10017 (US). 03 June 2017 (03.06.2017) (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/346,226 06 June 2016 (06.06.2016) US DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/376,856 18 August 2016 (18.08.2016) US HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/431,714 08 December 2016 (08.12.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/506,076 15 May 2017 (15.05.2017) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — New York, NY 10017 (US). = 3280 Avenida (84) Designated States (unless otherwise indicated, for every (72) Inventors: KUMPF, Robert Arnold; In- kind of regional protection available): ARIPO (BW, GH, = Anacapa, Carlsbad, CA 92009 (US). MCALPINE, C, San Diego, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — drawan James; 7190 Calabria Court, Unit 515 Hermes UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, CA 92122 (US). MCTIGUE, Michele Ann; Avenue, Encinitas, CA 92024 (US). PATMAN, Ryan; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = DERIVATIVES USEFUL AS ANTICANCER AGENTS (54) Title: SUBSTITUTED CARBONUCLEOSIDE = Q / = = = = = X ,Z y \N s( \ s LI — _ = ;(- ...%'\",..„... , ,,,;, 4 \".,... R 9 N R 2 R = 9 _ = = R 9 OH OH Il .4 HN kin GC 1. M AE 0-3 (R.), 3 ei (R 8 )1_6 1-1 ei IN 1-1 N (57) : Compounds of the general formula : processes for the preparation of these compounds, compositions containing these — compounds, and the compounds for use in treating cancer. [Continued on next page] WO 2017/212385 Al MIDEDIMOMOIDEIRMEMODIHMOIIIIMOMEHOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))