baber/WOPTO huggingface dataset:
Patent CA-3196299-A1 (CA)
Inventor: LI BAIYONG
IPC: C07K16/28
Filed: 2021-10-22
Abstract: An anti-CD73 antibody and the use thereof. The heavy chain variable region of the antibody comprises HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 15-17; and the light chain variable region of the antibody comprises LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 18-20.
Patent CA-3196492-A1 (CA)
Title: Membrane with guide surface
Inventor: SHEVGOOR SIDDARTH K
IPC: A61J1/20
Filed: 2021-10-27
Abstract: A membrane for a closed system transfer device includes a body having a first end and a second end positioned opposite the first end, the body defining a passageway extending from the first end of the body to a position intermediate the first end of the body and the second end of the body, and a guide member positioned within the passageway of the body. The guide member having a first end and a second end positioned opposite the first end, with the guide member having a guide surface configured to engage a needle positioned within the passageway of the body.
Patent CA-3198230-A1 (CA)
Title: Conjugate and use thereof
Inventor: CHEN JIAN
IPC: A61K47/68
Filed: 2022-01-28
Abstract: A compound of formula (I), or a tautomer, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound represented by formula (I) or the tautomer, the stereoisomer or the pharmaceutically acceptable salt thereof, as a novel linker compound, can be used for preparing an ADC medicament with a high DAR value. The present invention also relates to an ADC medicament prepared from the linker.
Patent CA-3201614-A1 (CA)
Inventor: LUNDVALL AXEL
IPC: B42D25/342
Filed: 2021-12-10
Abstract: A method for manufacturing a synthetic image device comprises providing (S10) of a focusing element array. An image layer is arranged (S20) in a vicinity of a focal distance of focusing elements of the focusing element array, whereby a synthetic image composed of enlarged portions of the image layer becomes perceivable for a viewer. The image layer comprises an array of image cells, each being associated with a respective focusing element and wherein the array of image cells has a same symmetry and element distance as the focusing element array. The arranging comprises creation (S22) of continuous image objects within the image cells such that synthetic images to be viewed, all having contributions from one of the continuous image objects, present smooth successive non-parallax alterations upon changing a viewing direction. This creation is performed (S30) according to an array of digital image cells of a digital image layer model.
Patent CA-3203642-A1 (CA)
Inventor: DOLEN GUL
IPC: A61K31/485
Filed: 2021-12-06
Abstract: Methods of improving motor function in subjects diagnosed with a central nervous system injury are contemplated as including an administration of a psychedelic, empathogenic, or dissociative compound in a pharmaceutically effective amount followed by administration of a motor skill restoration therapy. The psychedelic, empathogenic, or dissociative compound may be administered to a subject that has been determined to be therapy refractive with a chronic central nervous system injury, to a subject with a subacute central nervous system injury sustained within 7 days and 6 months prior, or to a subject with an acute central nervous system injury sustained within the past 7 days. Such methods may be seen improve motor function in the subjects.
Patent CA-3205204-A1 (CA)
Inventor: YANG WEI
Filed: 2023-06-27
Abstract: An aerosol dose testing device, applied to an aerosol-generating device which includes a flow channel structure for flowing an aerosol. The testing device includes a light emitting module, arranged on an inner wall of the flow channel structure for providing an emitting light into a flow channel; and a photosensitive module, arranged on the inner wall of the flow channel structure corresponding to a projection path of a scattering light, for receiving the scattering light and outputting a detection signal based on an output end. The scattering light includes a light formed by scattering of the emitting light projected onto the aerosol in the flow channel structure, and the detection signal is used for determining a dose of the aerosol.
Patent CA-3205767-A1 (CA)
Title: Active optical cables
Inventor: BLANC SCOTT G
IPC: G02B6/42
Filed: 2022-01-26
Abstract: In one embodiment, an opto-electronic assembly includes a housing having a cavity and an opto-electronic module disposed at least partially in the cavity of the housing. The housing is configured to support an electrical connection at a first end of the housing and support an optical connection at a second end of the housing. The opto-electronic module includes an opto¬ electronic transceiver, an electrical interface to provide an electrical connection to the opto¬ electronic module via the first end of the housing, a ferrule, and a lens, wherein the ferrule and the lens are to provide an optical connection to the opto-electronic module via the second end of the housing. The housing, the opto-electronic module, the opto-electronic transceiver, the electrical interface, and the ferrule have a magnetic permeability that is less than 1.0 B/H, where B is magnetic flux density and H is magnetic flux.
Patent CA-3206404-A1 (CA)
Inventor: STEELE DAVID JOE
IPC: E21B43/267
Filed: 2022-04-15
Abstract: Provided is a downhole rotary slip ring joint, a well system, and a method for accessing a wellbore. The downhole rotary slip ring joint, in one aspect, includes an outer mandrel, an inner mandrel operable to rotate relative to the outer mandrel, an outer mandrel communication connection coupled to the outer mandrel, and an inner mandrel communication connection coupled to the inner mandrel. The downhole rotary slip ring joint, according to this aspect, further includes a passageway extending through the outer mandrel and the inner mandrel, the passageway configured to provide continuous coupling between the outer mandrel communication connection and the inner mandrel communication connection regardless of a rotation of the inner mandrel relative to the outer mandrel, wherein the downhole rotary slip ring joint is operable to be coupled to a wellbore access tool.
Patent CA-3206437-A1 (CA)
Inventor: LARMOUR DONALD JOSEPH
IPC: B02C4/02
Filed: 2022-01-28
Abstract: L'invention concerne des procédés et des appareils pour former des pastilles, telles que des pastilles de potasse, par exemple. Les procédés impliquent l'alimentation de granulés agglomérés sur la surface fonctionnelle d'un ensemble de rouleaux. Les rouleaux sont alignés de manière à présenter des axes de rotation centraux parallèles et il y a un espace longitudinal entre des rouleaux adjacents. Pour former les pastilles, les rouleaux sont mis en rotation afin d'agiter et d'abraser les pastilles agglomérées sur la surface fonctionnelle de l'ensemble de rouleaux et former des pastilles.
Patent CA-3209159-A1 (CA)
Inventor: GLIDDEN PAUL
IPC: A61K31/7068
Filed: 2022-03-25
Abstract: L'invention concerne des compositions comprenant un premier composé hétéroaryle et un second composé hétéroaryle dissous dans un liquide aqueux. L'invention concerne également des méthodes de traitement d'un patient qui comprennent l'administration orale d'un tel liquide aqueux à un patient, par exemple, le patient ayant été diagnostiqué comme présentant un syndrome d'épuisement mitochondrial. L'invention concerne également des kits qui comprennent le premier composé hétéroaryle, le second composé hétéroaryle, et éventuellement des instructions pour dissoudre le premier composé hétéroaryle et le second composé hétéroaryle dans un liquide aqueux et administrer la solution à un patient.
Patent CA-3209951-A1 (CA)
Inventor: KAISTI MATTI
IPC: G16H50/30
Filed: 2022-02-22
Abstract: An apparatus for measuring compliance of blood vessels comprises a photoplethysmography sensor (101) for emitting electromagnetic radiation to the blood vessels, for receiving electromagnetic radiation reflected off the blood vessels, and for producing a measurement signal indicative of the received electromagnetic radiation. The apparatus further comprises a pressure instrument (102) for producing mechanical pressure applied on the blood vessels, and a control system (103) for controlling the pressure instrument to change the mechanical pressure linearly with respect to time during emission of electromagnetic radiation to the blood vessels and reception of reflected electromagnetic radiation from the blood vessels. The control system finds, from the measurement signal, a portion whose envelope has exponential change (~e?t or ~e-?t) with respect to time and produces an estimate for an exponent coefficient (?) of time during the exponential change. The coefficient is indicative of the compliance, as well as stiffness, of the blood vessels.
Patent CA-3211963-A1 (CA)
Title: Agencement d'un dispositif d'elevation pour un systeme d'arme monte sur un vehicule
Inventor: ERIKSSON CLAES
IPC: F41A27/06
Filed: 2022-02-25
Abstract: La présente invention concerne un agencement pour un dispositif d'élévation (E) d'un système d'arme monté sur un véhicule (C). Le système d'arme (C) comprend une arme (20) et une goulotte d'alimentation. Ledit dispositif d'élévation (E) est conçu pour permettre un mouvement d'élévation de l'arme (20) autour d'un axe d'élévation (Z). Ladite élévation s'effectue en liaison avec des côtés (E1, E2) dudit dispositif d'élévation (E) autour dudit axe d'élévation (Z). Ladite goulotte d'alimentation (40) est configurée pour être disposée en liaison avec un côté (E1). Ledit agencement comprend un dispositif de support de palier en forme d'arc (B1) d'une configuration de palier pour faciliter ladite élévation. Ledit dispositif de palier (B1) est disposé en liaison avec une partie avant (30F) au niveau dudit premier côté (E1) à une distance radiale dudit axe d'élévation (Z) de manière à fournir un espace pour ladite goulotte d'alimentation (40) sur ledit côté (E1) en liaison audit axe d'élévation (Z). L'invention concerne également un véhicule équipé d'un agencement selon la présente invention.
Patent CA-3212448-A1 (CA)
Inventor: AKMAEV VIATCHESLAV R
IPC: C12Q1/6883
Filed: 2022-03-17
Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides methods of treating subjects suffering from an autoimmune disorder, the method comprising: administering an anti-TNF therapy to subjects who have been determined to be responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy. For example, in some embodiments, the present disclosure provides methods of treating subjects suffering from an autoimmune disorder during therapeutic treatment, the method comprising: identifying responsive and non-responsive prior subjects over a time period beginning from the administering of the anti-TNF therapy.
Patent CA-3214126-A1 (CA)
Inventor: BODIN AASE
IPC: A24B13/00
Filed: 2022-04-05
Abstract: There is disclosed an oral pouched nicotine product comprising a filling material and a saliva-permeable pouch of a packaging material enclosing the filling material, the filling material comprising: - a non-tobacco material, - a nicotine source, - a flavouring agent, - moisture in an amount within the range of from 1 wt % to 50 wt% based on the total weight of the filling material, - a pH adjuster comprising one or more of the following: Na2CO3, K2CO3, MgCO3, NaHCO3, KHCO3, NaOH, KOH, and - optionally a tobacco material within the range of from 0.05 wt% to 5 wt% based on the total weight of the filling material, the packaging material comprising an acid selected from the group consisting of citric acid, malic acid, lactic acid, ascorbic acid, tartaric acid and any combination thereof, said acid being present in an amount within the range of from 5 wt %to 20 wt% based on the total dry weight of the packaging material. There is also provided a method for manufacture of the oral pouched nicotine product.
Patent CA-3215501-A1 (CA)
Title: Architecture d'agencement de centrale nucleaire modulaire distribuee
Inventor: BASS DEREK
IPC: G21C9/00
Filed: 2022-04-12
Abstract: Une centrale nucléaire comprend une structure nucléaire, un équipement de support de première ligne et une structure de support. La structure nucléaire comprend et est conçue pour la protection, contre tout dommage dû à un événement dommageable, d'un réacteur nucléaire et/ou d'un espace de stockage de combustible nucléaire. L'équipement de support de première ligne est conçu pour la mise en ?uvre d'une fonction de sécurité fondamentale. La structure de support est spatialement séparée de la structure nucléaire et comprend un équipement de support d'initiation conçu pour déclencher l'équipement de support de première ligne pour mettre en ?uvre la fonction de sécurité fondamentale de sorte que la fonction de sécurité fondamentale soit mise en ?uvre indépendamment de l'équipement de support d'initiation après son déclenchement. La structure de support peut être une structure non protégée qui n'est pas conçue pour la protection de l'équipement de support d'initiation contre des dommages dus à l'événement dommageable.
Patent CA-3216432-A1 (CA)
Title: Injectable anesthetic solution with a reduced bitterness
Inventor: RICHARD GILLES
IPC: A61K47/10
Filed: 2022-04-29
Abstract: The present invention relates to the field of anesthetics. Especially, the present invention refers to an injectable anesthetic solution having a reduced bitterness comprising: - an anesthetic agent; - optionally, a vasoconstrictor; - a pharmaceutically acceptable solvent; and - a bitterness suppressant comprising or consisting of a mixture of at least two among sodium saccharin, sorbitol and an amino acid, wherein the amino acid is selected from: serine, threonine and their mixtures. The present invention also relates to a method for providing said injectable anesthetic solution and its uses in dentistry, oral surgery and/or maxillofacial surgery.
Patent CA-3217612-A1 (CA)
Title: Determining method and apparatus for working voltage of isolated neutral system
Inventor: LIAN HAI TAO
IPC: G01R31/42
Filed: 2022-05-20
Abstract: The present invention provides a determining method and apparatus for a work-ing voltage of an isolated neutral system. A power system includes three phase wires and three capacitor banks. One terminal of each capacitor bank is connected to one phase wire, and the respective other terminals of the capacitor banks areconnected to one another to form a neutral point. Each capacitor bank includes a plurality of capacitors. The method includes: periodically sampling a phase volt-age of each phase wire, to obtain a plurality of groups of sampling values of re-al-time phase voltages, where each group of sampling values of real-time phase voltages includes a sampling value of a phase voltage of each phase wire that is obtained by simultaneously measuring each phase wire; determining unbalance rates between the capacitor banks based on the plurality of groups of sampling values of real-time phase voltages, where the unbalance rate is a ratio between capacitance values of every two phase wires; and determining a working voltage of the isolated neutral system based on the unbalance rates. The unbalance rates between the capacitor banks are obtained based on the sampling values of the phase voltages measured in real time, and the working voltage is accurately de-termined based on the unbalance rates, so that subsequent operations can be ac-curately performed.
Patent CA-3218760-A1 (CA)
Inventor: HESSION CHRISTOPHER J
IPC: B65D50/04
Filed: 2022-07-06
Abstract: L'invention concerne un boîtier comprenant une base, un couvercle primaire relié à la base, le couvercle primaire et la base délimitant une zone de stockage primaire, et un mécanisme de verrouillage. Le mécanisme de verrouillage comprend un élément flexible comprenant un premier segment et un second segment qui sont reliés par un coude, le premier segment étant relié au couvercle primaire, une extrémité distale du second segment comprenant au moins une structure de contact, l'élément flexible comprenant au moins une première structure de prise entre le coude et une surface avant de ladite structure de contact, et une seconde structure de prise sur une première paroi de la base. Le contenant comprend une paroi de réceptacle coopérant avec une paroi périphérique pour délimiter un réceptacle, et une patte flexible faisant saillie de la paroi supérieure, la patte flexible comprenant une extrémité fixe adjacente à la paroi supérieure et une extrémité libre opposée à l'extrémité fixe.
Patent CA-3219687-A1 (CA)
Inventor: RABANI ELI
IPC: A01H3/04
Filed: 2022-05-19
Abstract: The present invention provides enhanced systems for the efficient cultivation of photosynthetic organisms, methods and means for processing the biomass thereof to useful materials, and fabricating desired articles from said useful materials, including subsystems of the present invention. Enhancements include light management for efficient utilization of insolated energy, thermal management for utilization of low grade waste heat through ocean thermal energy conversion and/or radiative cooling, for preventing waste heat from operations in ocean deployments from contributing to sea- surface temperature rise and mitigation thereof, improved methods for functional film fabrication via an improvement on roll-to-roll fabrication-roll-to-scroll fabrication, processing of biomass comprising biosilica to silicon carbide and silicon nitride nanoparticles and sintering thereof, and integration of cultivation of primary producers with secondary cultivation of heterotrophic cells for cultured meat production or metabolic engineered production of desired bioproducts.
Patent CA-3223775-A1 (CA)
Inventor: ROTH ERNA
IPC: A23P20/10
Filed: 2022-07-07
Abstract: The invention refers to a composition, suitable as coating or binding agent for pharmaceutically, nutraceutically or cosmetically active ingredients, comprising the following components: a) at least one (meth)acrylate copolymer a), comprising polymerized units of 5 to 25 % by weight of methacrylic acid and 75 to 95 % by weight of C1- to C4-alkylesters of methacrylic acid and/or C1- to C4-alkylesters of acrylic acid, and b) 1 to 25 % by weight, based on the total weight of at least one (meth)acrylate copolymer a), of an alkali or ammonium salt of a saturated aliphatic monocarboxylic acid having 10 to 30 carbon atoms, and c) or d) or both c) and d) c) 2 to 25 % by weight, based on the total weight of a), of at least one compound selected from glyceryl tristearate, hydroxypropyl methylcellulose, glyceryl behenate, and glyceryl monostearate and/or d) 25 to 90 % by weight, based on the total weight of a), of at least one compound selected from talc, rice hulls in powder form, magnesium stearate, corn starch, and microcrystalline cellulose. Furthermore, the present invention refers to an aqueous dispersion, comprising water and 5 to 50 % by weight of the composition according to the present invention as well as a dosage form, comprising a pharmaceutically, nutraceutically or cosmetically active ingredient and a polymeric coating or a polymeric matrix, wherein the polymeric coating or the polymeric matrix comprises the composition according to the present invention. Finally, the present invention pertains to the use of a composition according to the present invention as a coating or binding agent for pharmaceutically, nutraceutically or cosmetically active ingredients.
Patent CA-3224778-A1 (CA)
Inventor: BHAT ADVAIT
IPC: B65D1/02
Filed: 2022-07-08
Abstract: A beverage container includes a base, a sidewall extending from and integrally formed with the base, and an upper region extending from the sidewall and defining an upper opening. The beverage container includes a longitudinal axis extending in a direction from the base to the upper opening. The beverage container further includes a continuous channel formed in and extending continuously around a circumference of the sidewall, wherein the continuous channel includes peaks and troughs connected by diagonal regions. The continuous channel is configured to resist paneling and elongation of the beverage container. The beverage container further includes a central channel formed in and extending continuously around a circumference of the sidewall at a central portion of the sidewall, wherein the central channel is configured to resist paneling of the beverage container.
Patent WO-9307798-A1 (WO)
Inventor: BRICKER JAMES C
IPC: A47L15/44
Filed: 1991-10-25
Abstract: Un appareil (12) permet de diffuser des détergents solides (18) ou semi-solides. Il comprend une ouverture creuse allongée ou goulotte (16) et une plaque recourbée (28) qui descend depuis la paroi latérale de l'appareil jusqu'au dessous de la goulotte. Cette plaque présente un support plat (17) destiné à une barre de détergent (18) placée dans la goulotte. On projette de l'eau (22) qui descend sur la plaque recourbée (28) et rebondit sur le détergent (18) soutenu par le support plat (17), ce qui le fait fondre puis s'écouler par un drain (23). La goulotte présente une géométrie spécifique lui permettant de recevoir une seule forme de barre de détergent. Lorsqu'une cuisine comporte plusieurs diffuseurs de détergents, chacun est doté d'une goulotte particulière de façon que seul le détergent approprié y soit utilisable.
Patent WO-9214134-A1 (WO)
Inventor: WONG PATRICK T T
IPC: G01N21/35
Filed: 1992-01-31
Abstract: Dans ce procédé, on détecte la présence d'anomalies dans des cellules exfoliées ( par exemple dans un frottis du col utérin) à l'aide d'un spectroscope à infrarouge. On dirige un faisceau de lumière infrarouge sur des échantillons renfermant des cellules qui peuvent être des sécrétions, des exsudats, des transsudats, des raclages, des brossages ou des populations de cellules exfoliées de divers organes ou tissus obtenues d'une autre manière, et on détecte l'anomalie au niveau d'au moins une gamme de fréquences en déterminant s'il s'est produit une modification de l'absorption de la lumière infrarouge qui est due à la vibration d'un groupe fonctionnel dans, par exemple, des groupes photodiester d'acides nucléiques, des groupes COH de protéines tissulaires, de glucides, ou qui peut être due à des dispositions particulières de molécules lipidiques ou à des structures lipidiques anormales, présentes dans l'échantillon.
Patent WO-9618632-A1 (WO)
Title: Procedes de preparation de series pures homologues de mono- a tetra-esters d'acyles gras de sucres; caracterisation d'un composant antitumoral en tant que tripalmitate 1, 6, 6' de maltose, et formulations pharmaceutiques utiles dans le traitement du cancer
Inventor: NIGAN N VIJAY
IPC: A61K31/70
Filed: 1995-12-18
Abstract: La présente invention concerne un procédé de fabrication de séries pures homologues d'esters d'acyles gras de sucres. La production de mono- à tétrapalmitates de maltose est particulièrement prise pour exemple. Des compositions spécifiques comportant des di-, tri- et tétrapalmitates de maltose manifestent une activité antitumorale. Des effets immunostimulateur et, dans une certaine mesure, antiangiogénique, sont aussi décrits et inclus dans les revendications. Ils peuvent être utilisés seuls ou en présence de stéroïdes angiostatiques pour traiter les affections dépendant de l'angiogénèse. La caractérisation d'un composé nouveau de ce genre, le tripalmitate 1, 6, 6' de maltose, qui est le composant actif de cette série, est décrite.