baber/WOPTO huggingface dataset:
Patent EP-1762230-B2 (EP)
Inventor: RÖHRICH LAMBERT TILLMANN
IPC: A61K31/529
Filed: 2006-08-10
Granted: 2016-04-20
Abstract: A film-coated tablet/granules comprising core containing pyridylpyrimidine compound (c1), or its salt (25 - 80 wt.%) (preferably imatinib or its monomethanesulfonate salt) and at least one filler-binder, and optionally other additives, is produced by pressing the starting materials, in which prior to pressing at least one of them has been dry-granulated (preferably compressed or compacted). Independent claims are included for the following: (1) production of the film-coated tablet or granules involving producing the tablet cores and the granules by pressing of the starting materials and, prior to pressing of the starting materials, at least one of them is dry-granulated (preferably compressed or compacted); and coating the resulting tablet cores and optionally granules with a film, where the starting materials contain the compound (c1) and at least one compound acting as filler-binder, and optionally other additives in the mixture, and the compound (c1) is present in an amount of 25 - 80 wt.%; (2) the tablet cores and granule cores which are not provided with a film coating and which are used as intermediates for the production of film-coated tablets and film-coated granules; and (3) powder mixtures which are used as intermediates for the production of the tablet cores and granule cores. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Tyrosine kinase inhibitor. No biological data given.
Patent EP-1894807-B2 (EP)
Inventor: MACKOWIAK GREGOR DIPL-ING
IPC: B61F5/24
Filed: 2006-09-01
Granted: 2013-11-20
Abstract: The bogie has two longitudinal supports (3) with a transverse support (5), connected with the longitudinal support and with a torsion bar (15). The torsion bar runs parallel to the transverse support. One of the transverse supports has a crank (11) at each end. The torsion bar is arranged in the area of the crank, which is inside the transverse support. The bogie has two crankshaft transverse supports.
Patent EP-1842920-B2 (EP)
Inventor: STAFFORD DARREL
IPC: C12Q1/68
Filed: 2004-09-23
Granted: 2017-06-21
Abstract: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin.
Patent EP-1967116-B2 (EP)
Inventor: ENNEN GÜNTHER DR
IPC: A47L9/28
Filed: 2008-02-01
Granted: 2015-05-06
Abstract: The method involves controlling a driving direction based on a position-dependent condition parameter of a floor space, which is detected with a sensor device e.g. piezoelectric dust quantity sensor. A degree of pollution of an individual area of the floor space is recorded as the condition parameter by a control unit (7) during cleaning of the floor space. Emerging dirt, which is detected by the sensor device, is determined and stored by the control unit. The control unit controls processing intensity of the area in a flowing processing cycle based on the degree of pollution.
Patent EP-2287305-B2 (EP)
Inventor: MCSWIGGEN JAMES
IPC: C12N15/09
Filed: 2003-02-20
Granted: 2017-11-29
Abstract: The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Patent EP-0109463-B2 (EP)
IPC: C08L33/20
Filed: 1982-11-23
Granted: 1989-10-18
Abstract: The present invention relates to a polymeric binder composition comprised of two polymeric components wherein one of the two polymeric components is a lightly cross-linked copolymer comprising, in polymerized form, an  alpha , beta -ethylenically unsaturated carboxylic acid, an ester of an  alpha , beta -ethylenically unsaturated carboxylic acid and an unsaturated nitrile. In general, such cross-linking is achieved using a small amount of a cross-linking such as allyl methacrylate.
Patent EP-0155569-B2 (EP)
IPC: H04B1/58
Filed: 1985-03-01
Granted: 1991-12-27
Abstract: 1. Device for matching a bidirectional amplifying circuit arranged in a telecommunication line to the telecommunications line, the amplifying circuit having two separate amplifiers (V1 and V2) in a termination amplifying circuit, one for each direction of speech, characterized in that the transition attenuation of each termination circuit (G1, G2) is increased by ending the termination circuit with a balancing network (NB) containing an inductance (U, Dr) whose value corresponds to the inductance of the local line transformer (OLU) nearest to the termination circuit (G1, G2) in the telecommunications line.
Patent EP-0214358-B2 (EP)
IPC: F16K47/02
Filed: 1986-01-22
Granted: 1992-10-14
Abstract: 1. Sanitary water fitting, especially in the form of a single handle-mixing valve unit, having a housing (14), a handle (6, 11), a control unit (3) with discs, pistons, ball members or the like and having a closing damper for prolonging the closing time and reduction of the closing speed, characterized in that the closing damper (7, 8, 12, 13) is provided between the handle (6) and the control unit (3) or between the handle (11) and the fitting housing (14).
Patent EP-0282551-B2 (EP)
Inventor: TENNIGKEIT JUERGEN
IPC: A61K8/23
Filed: 1987-08-19
Granted: 1994-07-20
Abstract: Dans un procédé pour teindre par oxydation les cheveux humains ou un pelage animal, on prépare, immédiatement avant l'application, à partir d'au moins un colorant d'oxydation sous forme de crème ou de gel et d'un agent oxydant, un agent de teinture des cheveux qui est réglé sur un pH compris entre 5,9 et 6,9. On effectue la préparation en ajoutant à titre de catalyseur au moins un sel métallique, cette adjonction ayant lieu en même temps que ou immédiatement après le mélange du colorant d'oxydation avec l'agent oxydant, et la quantité ajoutée étant mesurée de telle manière que l'agent de teinture des cheveux prêt à l'emploi en contienne une proportion comprise entre 0,0001 et 1,00 % en poids, de préférence entre 0,0004 et 0,001 % en poids. Les sels métalliques utilisés comme catalyseurs sont de préférence sélectionnés dans le groupe composé du chlorure de cuivre II, sulfate de cuivre II, chlorure de cobalt, sulfate cérique et sulfate de vanadium.
Patent EP-0788523-B2 (EP)
Inventor: GROSS LUTZ-WERNER
IPC: B05D7/00
Filed: 1995-10-25
Granted: 2002-11-27
Abstract: The present invention relates to a coating formulation for use in multicoat paint systems, whicha) comprises as binder a water-dilutable polyurethane resin which has an acid number of from 10 to 60 and a number-average molecular weight of from 4000 to 25,000 and can be prepared by reacting with one anotheraa) a polyester-and/or polyether-polyol having a number-average molecular weight of from 400 to 5000 or a mixture of such polyester-and/or polyether-polyols,bb) a polyisocyanate or mixture of polyisocyanates,cc) a compound which has in the molecule at least one group which in reactive toward isocyanate groups and at least one group which is capable of forming anions, or a mixture of such compounds, and optionallydd) a hydroxyl-and/or amino-containing organic compound having a molecular weight of from 40 to 400, or a mixture of such compounds and at least partially neutralizing the resulting reaction product, andb) comprises pigments and/or fillers, the ratio of binder to pigment being between 0.5:1 and 1.5:1.
Patent EP-0792292-B2 (EP)
Inventor: KUIPER GEORGE G J M
IPC: C12N15/12
Filed: 1996-09-09
Granted: 2009-04-15
Abstract: This invention relates to a novel estrogen receptor-related nuclear receptor, hereinafter termed "ER beta " having the amino acid sequence of Figs. 1, 13A or 14A or substantially the same amino acid sequence as the amino acid sequence shown in Figs. 1, 13A or 13B or an amino acid sequence functionally similar to that sequence. The invention also relates to DNA sequences encoding the receptor. The receptor may be useful in isolating molecules for the treatment of disorders such as prostate cancer, benign prostatic hyperplasia, osteoporosis or cardiovascular disorders and in the testing of substances for estrogenic and other hormonal effects.
Patent EP-0875378-B2 (EP)
Inventor: SCHILD HELMUT
IPC: B41F27/12
Filed: 1998-04-11
Granted: 2003-09-10
Abstract: The two-part clamp has the one part fixed to the cylinder and the other part movably mounted in at least the radial direction of the cylinder. An actuator opens and clamps and is positioned on the movable top or bottom part (2,3). Components transmit clamping force onto the movable top or bottom part. At least one component in the form of a shaft (7) possesses sprung elasticity effective when clamping force builds up. The shaft is supported on bearings (6) between each pair of which is at least one cam co-operating with a roller.
Patent EP-0892883-B2 (EP)
Inventor: FETZER GERHARD
IPC: E05D11/00
Filed: 1998-01-20
Granted: 2005-07-06
Abstract: PCT No. PCT/DE98/00160 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Jan. 20, 1998 PCT Pub. No. WO98/36144 PCT Pub. Date Aug. 20, 1998The invention relates to a drilling device having a base plate and a positioning plate. The positioning plate bears a tool guide bush and two tool guide mechanisms for producing a principal drilled hole for the main body of a hinge, and two screw holes for the hinge fastening screws.
Patent JP-H0819946-B2 (JP)
IPC: C22C21/00
Filed: 1992-04-28
Abstract: A multilayer aluminum-based alloy plain bearing having superior compatibility and superior fatigue resistance, comprising a steel back metal, an aluminum alloy intermediate bonding layer bonded to the steel back metal, and an Al-Sn-Si family bearing alloy layer bonded to the intermediate bonding layer, the aluminum bearing alloy layer consisting, by weight, of 7 to 15% Sn, 0.5 to 3% Si, and the balance Al and incidental impurities, the hardness of the aluminum bearing alloy layer being less than 50 Vickers hardness, the aluminum alloy intermediate bonding layer consisting, by weight, of at least one kind selected from the group consisting of 0 to 1.7% Mn, 0 to 1.2% Cu and 0 to 1.8% Mg, and the balance Al and incidental impurities, Vickers hardness of the aluminum alloy intermediate bonding layer being in a range of not less than 60% of the Vickers hardness of the aluminum bearing alloy layer but not more than 120% of the Vickers hardness of the aluminum bearing alloy layer.
Patent JP-3226597-B2 (JP)
IPC: C07C263/18
Filed: 1992-04-03
Granted: 2001-11-05
Abstract: In the method, organic isocyanates are mixed at 20 to 150 DEG C with 0.001 to 1 mol%, relative to the amount of isocyanate, of a silylated acid and, if desired, the mixture thus obtained is subjected to a distillative work-up after a residence time of at least 5 minutes.
Patent JP-H0822914-B2 (JP)
IPC: C08G67/02
Filed: 1987-05-14
Abstract: Novel catalyst composition, characterized in that they are based upon   a) a palladium compound, b) an anion of an acid with a pKa of less than 2, with the proviso that the acid is not a hydrohalogenic acid, c) a bisphosphine of the general formula R1R2P-R-PR3R4. wherein R1-R4 are similar or dissimilar hydrocarbyl groups which may or may not be substituted with polar groups, with the proviso that at least one of the groups R1-R4 represents a polarly substituted aryl group containing at least one polar substituent on a position ortho to phosphorus, and wherein R represents a bivalent organic bridging group containing at least two carbon atoms in the bridge, and d) optionally, a quinone.
Patent JP-3342915-B2 (JP)
IPC: A61B17/064
Filed: 1993-05-11
Granted: 2002-11-11
Abstract: The invention relates to a clip for surgical purposes, made from bendable wire-like material. Conventional clips have an essentially rectilinear base from each end of which a limb projects. Upon application in endoscopic operations, i.e. when the clips are pushed forward through trocar cannulae, it is disadvantageous that the rectilinear base can only be so long that it can be pushed forward transversely through a trocar cannula. As a result, only small clips have been usable thus far with pre-set trocar diameters. According to the invention, a clip is so designed that the base is shaped bent backwards, starting from its centre section, on both sides, opposite to the direction of the limbs (42, 44), so far that the ends (12, 14) of the base touch or come close to each other, base (10) and limbs (42, 44) forming an essentially  OMEGA -shaped contour. The bent-back configuration effects a substantial reduction in the lateral extension of the clip when it is pushed forward through the trocar cannula, so that endoscopically larger clips than usual can be set with a suitable clip setter. <IMAGE>
Patent JP-3403218-B2 (JP)
IPC: A61P3/06
Filed: 1993-06-11
Granted: 2003-05-06
Abstract: Bile acid derivatives of the formula I  Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.
Patent JP-H07107059-B2 (JP)
IPC: C07D249/18
Filed: 1986-06-27
Abstract: 1. A compound of the general formula I.  see diagramm : EP0207415,P7,F1  in which R**1 is an aliphatic or aromatic radical having up to 10 carbon atoms and X is a succinimide or benzotriazole residue.
Patent JP-2916823-B2 (JP)
IPC: C07C37/80
Filed: 1991-05-31
Granted: 1999-07-05
Abstract: A stream of raw phenol, coming from the acidic cracking of cumene hydroperoxide, is purified by means of a process of extractive distillation carried out in the presence of acetophenone.
Patent JP-3904763-B2 (JP)
IPC: G10L15/183
Filed: 1999-06-07
Granted: 2007-04-11
Abstract: PROBLEM TO BE SOLVED: To provide a voice recognition device capable of improving recognition accuracy of a word line without causing increase of a data quantity by providing a word probability computing means directly referring to corpus as the analysed result of an illustrative sentence as for a word chain of which the frequency of occurrence becomes one. SOLUTION: A microphone 11 converts input voice into an electric signal and outputs it, a phoneme probability computing device 12 converts this electric signal into a phoneme, and computes phoneme generating probability corresponding to each phoneme to output a phoneme line candidate. A word probability computing device 15 refers to a n-gram phoneme index 13 storing the phoneme line of an objective word, a word transcribed line corresponding to the phoneme line, and frequency of occurrence, and computes the word generating probability of each word candidate corresponding to the phoneme line candidate output by the phoneme probability computing device 12.  Hereat, as to a word chain of which the frequency of occurrence becomes one, corpus 14 as the analysed result of an illustrative sentence is directly refered, and the word generating probability of each word candidate corresponding to the phoneme line candidate is computed.
Patent JP-H0634758-B2 (JP)
Inventor: EREIZAA RABANII
IPC: C12Q1/68
Filed: 1985-08-29
Abstract: Described is a genetic analyses using the technique of nucleic acid hybridization. The genetic analyses includes, for example, the diagnosis of infections by foreign microbes and the detection of specific genetic traits and abnormalities. Furthermore, a technique for the detection of the presence of a polynucleotide sequence of interest is described.
Patent JP-H0530997-B2 (JP)
IPC: F04C2/10
Filed: 1982-10-27
Abstract: When as the dimensions of an inner rotor of a rotary pump utilizing the trochoidal curve, a diameter of a base circle is represented by A mm, a diameter of a rolling circle by B mm, a diameter of a rotary path by C mm, an eccentricity by e mm, an eccentricity ratio by fe = e/B, a ratio of rotary path by = C/B, a ratio of base circle by n = A/B, a minor diameter of inner rotor by d4, and the number of teeth of inner rotor by n1, and K0 = (A/B + 1) x | B - 2e | and k1 = (n + 1) x | 1 - 2fe are given, the inequality or equality: C/K0 </= fc/K1 </= 1.1 is satisfied. 
<??>The invention provides a rotor for a rotary pump which is at least substantially free from the generation of a duplicate portion or an edge portion.
Patent JP-2883173-B2 (JP)
IPC: C12P35/06
Filed: 1990-07-18
Granted: 1999-04-19
Abstract: A method for deactivation of esterase enzyme and an improved enzymatic process for the oxidation of Cephalosporin C to glutaryl-7-ACA.
Patent JP-3113398-B2 (JP)
IPC: G08B17/103
Filed: 1992-06-30
Granted: 2000-11-27
Abstract: PURPOSE:To prevent the blank time in a smoke detection operation by being generated by detecting the non light emission of a light emitting lamp and alarming that the limit of the life of the light emitting lamp is close when the number of the times of the non light emission is more than the prescribed number of times. CONSTITUTION:From the time when a smoke sensor 1 is installed or a xenon lamp 10 is exchanged, the number of times when the xenon lamp 10 does not emit the light at the time to emit the light, that is, the number of the times of the non light emission is stored every month. That is, when a light emitting level by a light receiving element 20 does not arrive at a prescribed level at the time of a light emitting instruction from a control circuit 50, the number of the times of the non light emission is increased by '1.' Then, the number at every month is stored in an EEPROM 63. The total number of the times of the non light emission in the month and the figure of an alarm level, 7 times for instance, are compared by the control circuit 50 every month and a life alarm signal is outputted when the total number of the times of the non light emission in the month is more than 7. Thus, the failure of the xenon lamp 10 can be recognized beforehand and the blank period in the smoke sensing operation is not generated.
Patent JP-H0655687-B2 (JP)
IPC: C07C29/16
Filed: 1986-08-29
Abstract: Alpha-substituted alpha-olefins are rapidly hydroformylated in high selectivity to aldehyde product using homogeneous rhodium catalysts modified with highly sterically hindered tricycloalkyl phosphine ligands under mild process conditions.
Patent JP-H0749431-B2 (JP)
IPC: A61P25/28
Filed: 1990-08-09
Abstract: The invention relates to 1-oxa-2-oxo-8-azasprio [4,5]decane derivatives of formula (I), <CHEM>  wherein  X represents an oxygen atom or an NR group,  wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6 cycloalkyl group, or a carbocyclic C6-10 aryl or carbocyclic C6-10 aryl-C1-14 alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4 alkoxy groups; R<1> and R<2> together represent a methylene group or, when X is a NR group, one of R<1> and R<2> additionally represents a hydroxyl group and the other additionally represents a methyl group; R<3> represents a hydrogen atom or a phenyl group optionally substituted by one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy or hydroxyl group; Ph represents a phenyl group unsubstituted or substituted by one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy, hydroxyl or trihalomethyl groups; and  n is 1, 2, 3; and optical isomers and mixtures thereof and all acid addition and quaternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess calcium, uptake-inhibiting, antihypoxic and antianoxic properties and a low toxicity. Thus, they are useful for the treatment of brain damage of various origin.
Patent JP-4390226-B2 (JP)
IPC: H01M10/0562
Filed: 1998-07-10
Granted: 2009-12-24
Abstract: PROBLEM TO BE SOLVED: To provide a stacked type secondary battery with high productivity. SOLUTION: This manufacturing method contains a battery element forming process for forming an electronic conductivity insulating layer between electrodes; an inspection process for inspecting short between electrodes of the battery element, and selecting an acceptable element judged as no short from a rejected element judged as short; a stacked cell forming process for stacking a plurality of acceptable elements selected in the inspection process; and a packaging process for packaging the stacked element obtained in the stacked element forming process in a case.
Patent JP-H055256-B2 (JP)
IPC: C08K3/36
Filed: 1986-09-12
Abstract: The filler comprises at least one precipitated silica with the following characteristics:
       - a CTAB surface area of between 20 and 200 m<2>/g,
       a mean aggregate projected area greater than 10,000 nm<2>,
       - a high interaggregate volume of at least 1 cm<3>/g and a homogeneous interaggregate pore population.
Patent JP-H0542-B2 (JP)
IPC: A43B5/08
Filed: 1984-10-19
Abstract: The present invention relates to an elastomeric support surface having a network of sculptures. According to the invention, the support surface is formed with a transverse network of narrow channels (2) having periodical widened portions (3) in each channel, a tong (4) of a width less than the width of the walls defining the channel and of a height equal to the depth of the channel being provided axially in each widened portion (3). Such a support surface is notably designed for forming the treading surface of so-called marine shoes in order to drain-off the water which can accumulate inside the sculptures.
Patent JP-H0433191-B2 (JP)
IPC: H04N3/185
Filed: 1985-10-04
Abstract: A combinatorial circuit component for television sets with an overload protection circuit on the primary side and a secondary-side regulating circuit and starting circuit with final disconnection of the mains section. The protective circuit, which comes into play in the event of anomalies on the primary side, causes a jump in the negative voltage on the secondary side. This is compared with a secondary (standby) voltage, created independently of the combinatorial circuit, in a comparator, which supplies a control voltage to which the secondary protection circuit responds thus interrupting the excitation of the switch in the mains section.
Patent JP-3605150-B2 (JP)
IPC: G01R31/319
Filed: 1994-08-22
Granted: 2004-12-22
Abstract: An address pattern generator for testing a semiconductor device, particularly, a synchronous DRAM (SDRAM) is disclosed. The address pattern generator can switch an interleave mode and a sequential mode of address generation for a SDRAM during a test process in real time and generates column addresses for the SDRAM by a Y address generation section alone. The address generator includes an address selector that selects and outputs from a lower Y address signal, a Z address signal, and an operation mode control signal, a conversion memory that outputs data based on a conversion table, a multiplexer that selects and outputs an output from the conversion memory and the lower Y address signal in accordance with a burst length control signal. In another aspect, the address pattern generator includes a counter that loads the lower address signal from the Y address generator section for the sequential mode while a fixed value for the interleave mode, an exclusive OR gate that receives an output signal of the counter to an input terminal and the lower address signal from the Y address generation section to the other input terminal, and a multiplexer that selects the output signal of the counter for the sequential mode and the output signal of the exclusive OR gate for the interleave mode.