Patent SG-11201900619X-A (SG)
Title: Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors
Inventor: DYCKMAN ALARIC J
IPC: C07D417/14
Filed: 2017-07-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIPO I PCT °mons °nolo omolom (10) International Publication Number WO 2018/026620 Al (51) International Patent Classification: CO7D 401/14 (2006.01) A61K 31/404 (2006.01) CO7D 405/14 (2006.01) A61K 31/454 (2006.01) C07D 401/04 (2006.01) A61P 29/00 (2006.01) C07D 417/14 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/US2017/044091 (22) International Filing Date: 27 July 2017 (27.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 11026137 30 July 2016 (30.07.2016) IN (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (72) Inventors: DYCKMAN, Alaric J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). DODD, Dharmpal S.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). MUSSARI, Christopher P.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Prince- ton, New Jersey 08543 (US). HAQUE, Tasir S.; 351 Denny Drive, Yardley, Pennsylvania 19067 (US). POSS, Declarations under Rule 4.17: Michael A.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). LOMBARDO, Louis J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). MACOR, John E.; 55 Com- manders Drive, Washington Crossing, Pennsylvania 18977 (US). PASUNOORI, Laxman; c/o SYNGENE INTER- NATIONAL LIMITED, Biocon Special Economic Zone, Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV Phase, Jigani Link Road, Bommasandra, Banga- lore, Karnataka 560 099 (IN). KUMAR, Sreekantha Rat- na; c/o SYNGENE INTERNATIONAL LIMITED, Biocon Special Economic Zone, Biocon Park, Plot No. 2 & 3, Bom- masandra Industrial Area IV Phase, Jigani Link Road, Bom- masandra, Bangalore, Karnataka 560 099 (IN). (74) Agent: GREENBLATT, Gary D. et al.; Bristol-Myers Squibb Company, Route 206 & Province Line Road, Prince- ton, New Jersey 08543 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) (54) Title: DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS W O 20 18/0266 20 Al (57) : Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R 5 , m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll- like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and au- toimmune diseases.