baber/WOPTO huggingface dataset:
Patent IL-104201-A0 (IL)
Title: 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them
IPC: A61P19/10
Filed: 1992-12-22
Abstract: Vitamin D2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1 alpha ,25-dihydroxyvitamin D2 and its 24-epimer are described. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1 alpha ,25-dihydroxyvitamin D3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds find utility in the treatment of diseases where bone formation is desired, such as osteoporosis.
Patent IL-112887-A0 (IL)
Title: 1 -fluoro-25- hydroxy-16-ene-23-yne-cholecalciferol its preparation and pharmaceutical compositions containing it
IPC: A61P3/02
Filed: 1995-03-06
Abstract: This invention is for 1α-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol, which can be further characterized by the formula:and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis. It can be prepared by removing the silyl protecting groups from a corresponding compound with silyl protected hydroxy groups.
Patent IL-120895-A0 (IL)
Title: Intermediates for manufacture of novel aryl substituted heterocycles
IPC: C07D211/20
Filed: 1997-05-22
Abstract: The present invention concerns the novel aryl substituted heterocycles of formula I, set out below, <CHEM> wherein R<2>, R<3> and R<4> have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment, methods for their use, and processes and novel intermediates for their manufacture.
Patent IL-130949-A0 (IL)
Title: Characterising polypeptides
IPC: C12Q1/37
Filed: 1998-01-23
Abstract: PCT No. PCT/GB98/00201 Sec. 371 Date Sep. 10, 1999 Sec. 102(e) Date Sep. 10, 1999 PCT Filed Jan. 23, 1998 PCT Pub. No. WO98/32876 PCT Pub. Date Jul. 30, 1998A method for characterizing polypeptides, which comprises: (a) treating a sample comprising a population of one or more polypeptides with a cleavage agent which is known to recognize a specific amino acid residue or sequence in polypeptide chains and to cleave at a cleavage site, whereby the population is cleaved to generate peptide fragments; (b) isolating a population of the peptide fragments which bear at one end a reference terminus comprising either only a C-terminus or only an N-terminus and which bear at the other end the cleavage site proximal to the reference terminus; and c) determining a signature sequence of at least some of the isolated fragments, which signature sequence is the sequence of a predetermined number of amino acid residues running from the cleavage site; wherein the signature sequence and the relative position of the cleavage site to the reference terminus characterize the polypeptide or each polypeptide.
Patent IL-132383-A0 (IL)
Title: Connector system
IPC: H01R13/639
Filed: 1998-04-03
Abstract: A connector unit 1 comprises a latching shell 3 having three peripheral resilient tongues 4 at substantially 120 DEG  from one another each bearing an outwardly projecting latch 5. A catching sleeve 28 also arranged in the connector unit 1 has three peripheral arms 30 at substantially 120 DEG  from one another each provided with an inner latch catching groove 31. The peripheral arms 30 of the catching sleeve 28 are located angularly between the resilient tongues 4 of the latching shell 3, whereby the latches 5 are circumferentially alternating with the latch catching grooves 31. <IMAGE>
Patent IL-137851-A0 (IL)
Title: S-SUBSTITUTED 11β-BENZALDOXIME-ESTRA-4,9-DIENE-CARBONIC ACID THIOLESTER DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IPC: A61K31/565
Filed: 1999-02-10
Abstract: Thiol esters of S-substituted 11beta-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula Itheir pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. These compounds bind to progesterone receptors and have distinctly reduced anti-glucocorticoid action.
Patent IL-139613-A0 (IL)
Title: Basb029 polynucleotide(s) and polypetides from neisseria meningitidis
IPC: C12N15/31
Filed: 1999-05-07
Abstract: The invention provides BASB029 polypeptides and polynucleotides encoding BASB029 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
Patent IL-149069-A0 (IL)
Title: Regulators of the hedgehog pathway, compositions and uses related thereto
IPC: A61P25/28
Filed: 2000-10-13
Abstract: The present invention makes available,  inter alia,  methods and reagents for modulating  smoothened-dependent  pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from  hedgehog  gain-of-function,  ptc  loss-of-function or smoothened gain-of-function mutations.
Patent IL-149568-A0 (IL)
Title: RECOMBINANT β-L-IDURONIDASE, METHODS FOR PRODUCING DISEASES CAUSED BY DEFICIENCIES THEREOF
IPC: A61K38/43
Filed: 2000-11-09
Abstract: The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, ±-L-iduronidase enzyme as well as methods to treat certain genetic disorders including ±-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
Patent IL-187164-A0 (IL)
Title: Membrane for filtering of water
Filed: 2007-11-05
Abstract: Membranes and devices incorporating them are useful in water filtration and purification. Disclosed are water membranes comprising aquaporin water transport proteins that have been reconstituted in lipid vesicles and transformed into a supported layer. Also disclosed are water purification devices/systems, including reverse osmosis filtering devices that include the membranes, methods of preparing the membranes and devices, and their use in methods of water purification.
Patent RO-128921-A0 (RO)
Title: Complex liquid fertilizer with anti-chlorosis properties, for preventing and treating nutritional deficiencies, process for obtaining and method for applying the same
Inventor: SIRBU CARMEN EUGENIA
IPC: C05C5/00
Filed: 2012-11-01
Abstract: The invention relates to a liquid fertilizer with anti-chlorosis properties, for preventing and treating nutritional deficiencies, to a process for obtaining and a method for applying the same. According to the invention, the fertilizer consists of: total nitrogen 25.72...101.3 g/l, phosphorus 20.56...60.82 g/l expressed as PO, potassium 24.51...53.46 g/l expressed as KO, iron 10.12...24.22 g/l, zinc 0.16...0.95 g/l, copper 0.04...0.56 g/l, magnesium 0.66...4.96 g/l, manganese 0.03...0.50 g/l, boron 0.25...0.73 g/l, sulphur 13.04...31.63 g/l, organic substances 125.45...258.42 g/l. As claimed by the invention, the process consists in obtaining, at the temperature of 60...75°C and by continuously stirring a complex iron chelate solution, in adding meso and micro-elements Cu, Zn, Mn, Mg and B complexed with the tetrasodium salt of the ethylendiaminotetraacetic acid, bringing the resulting solution to the 1-liter volume with a solution of macro-nutrients containing nitrogen as ammonia, nitrate and amide, primary and secondary potassium phosphates, humic substances and protein-hydrolyzates, followed by the filtration thereof. As claimed by the invention, the method for applying the liquid fertilizer consists in using the product in viticulture and fruit farming by spraying it as aqueous solution of 1...2.5% concentration in a quantity of 1000...1500 liters/ha, depending on the vegetation stage.
Patent MA-20150204-A1 (MA)
Inventor: BOUYA MOHSINE
IPC: C02F103/08
Filed: 2013-11-26
Abstract: يقدم هذا الإختراع و تعتمد هذه الطريقة على التبخر الجزئي لنسبة تتراوح بين %10 و %30 من ماء البحر بالاعتماد على أعمدة متصاعدة بتاتيرات متعددة
Patent MA-38159-A1 (MA)
Title: Anticorps isoles qui se lient a l'antigene bcma utilises pour traiter des cancers, par exemple cancer des cellules b et myelome multiple
Inventor: WANG ZHULUN
IPC: C07K16/28
Filed: 2013-12-05
Abstract: La présente invention concerne des protéines de liaison à l'antigène bcma (antigène de maturation des lymphocytes b), telles que des anticorps, des séquences polynucléotidiques codant pour lesdites protéines de liaison à un antigène, et des compositions et des méthodes pour le diagnostic et le traitement de maladies. La présente invention concerne également des conjugués de médicament anticorps bcma et leurs utilisations.
Patent MA-44838-A1 (MA)
Title: Système et procédé de production de matériaux de construction en mélange sec pourvu de propriétés d’ingénierie améliorées
Inventor: BAWRI BINOD KUMAR
IPC: B28C5/00
Filed: 2016-12-28
Abstract: La présente invention concerne un système et un procédé de production d’une variété de matériaux de construction en mélange sec et auxiliaires (dmc) pourvu de propriétés structurelles améliorées. Lesdits système et procédé emploient une unité de classification de matériau (204) qui classifie au moins l’une de la pluralité des matières premières (a, b, …, n) sur la base de leur taille de particule et de leurs propriétés physiques. Ces matières premières triées sont stockées séparément dans des compartiments de manipulation de matériau (260) et sont sélectionnées selon les exigences de qualité de construction de l’utilisateur final. L’invention consiste en outre en l’utilisation d’une unité de sélection de matériau (210) qui contrôle le fonctionnement de divers composants de la présente invention. Lesdits système et procédé fournissent également un moyen facile de réutilisation des produits de déchets industriels tels que les cendres volantes, le laitier de haut-fourneau en vue de produire toute une gamme de matériaux de construction et de matériaux de construction auxiliaires.
Patent UY-28513-A1 (UY)
Title: Nuevos compuestos
Inventor: PETER HANSEN
IPC: A61P29/00
Filed: 2004-09-15
Abstract: Se proporcionaron compuestos nuevos de fórmula (I) en donde R1, R2, R4, R5, G1, G2, L, Y y n son como se define en la memoria descriptiva e isómeros, racematos y tautómeros ópticos de los mismos; junto con procesos para su preparación, composiciones que los contienen y su uso en terapia. Los compuestos son inhibidores de la elastasa de neutrófilo.
Patent UY-30509-A1 (UY)
Title: Profarmacos antimicrobianos de oxazolidinona
Inventor: TENNAKOON MANOMI A
IPC: A61P31/00
Filed: 2007-07-27
Abstract: Esta invencion incluye compuestos de profármacos de oxazolidinona de Formula (I) y Formula (II) segun se define en la presente. Los profármacos se convierten, mediante procesos biologicos naturales, en un ingrediente activo que posee propiedades antimicrobianas utiles en el tratamiento de las infecciones bacterianas en mamíferos.
Patent ES-165313-A1 (ES)
Title: Un montaje de circuito mezclador
Filed: 1944-03-24
Abstract: Un montaje de circuito mezclador más especialmente para ondas cortas en el cual las oscilaciones de entrada son suministradas en push-pull y las oscilacion locales en montaje monofásico al electrodo de entrada de dos sistemas de descarga (sistemas mezcladores) y en el cual el circuito (monofásico) que está constituído por las impedancias conectadas por parejas en paralelo de las dos mitades del circuito push-pull y las impedancias de entrada conectadas en paralelo de los dos sistemas de descarga juntamente con las impedancias comunes a los circuitos de entrada de los dos sistemas se sintoniza a la frecuencia de las oscilaciones locales.
Patent ES-179458-A1 (ES)
Title: Mejoras en los transformadores
Filed: 1947-08-25
Abstract: Mejoras en los transformadores estabilizadores de tensión caracterizadas porque se disponen shunts magnéticos en el núcleo entre el primario y el secundario del transformador, y un condensador se conecta con los bornes del secundario y se sintoniza a la velocidad de la resonancia.
Patent ES-184245-A1 (ES)
Title: PERFECCIONAMIENTOS EN LAS CHIMENEAS, ESPECIALMENTE PARA VEHiCULOS TERRESTRES Y MARiTIMOS
Filed: 1948-06-24
Abstract: Perfeccionamientos introducidos en las chimeneas especialmene para vehículos terrestres o marítimos consistentes en crear en las cercanías de la extremidad del conducto de humos un torbellino concentrado llamado marginal en cuyo núcleo o centro se opera en desprendimiento del humo que por consiguiente se encuentra guiada así a la salida del conducto de humos a manera de una tubería rígida por la membrana formada por el torbellino.
Patent ES-190924-A1 (ES)
Title: UN PROCEDIMIENTO MEJORADO PARA LA FABRICACIoN DE GAFAS PLEGABLES
Filed: 1949-12-22
Abstract: Procedimiento mejorado para la fabricación de gafas plegables caracterizado por realizarse un troquelaje sobre una plancha metálica obteniéndose una pieza o tira en la que están comprendidos todos los elementos peculiares de uno de os anteojos dispuestos solidariamente sobre dicha tira la cual es acanalada y posteriormente curvada para la montura de los cristales.
Patent ES-190938-A1 (ES)
Title: UNA MEJORA EN LAS CARDAS MIXTAS O COMBINADAS PARA ALGODoN
Filed: 1949-12-23
Abstract: Mejora en las cerdas mixtas o combinadas para algodón que esencialmente consiste en acortar un tanto los chapones de la carda por la parte correspondiente el la entrada en la máquina a fin de aumentar el sector del tambor comprendido entra el punto da incorporación del algodón en el mismo y el primer chapón estableciendo en el indicado sector dos tres o más cilindros peinadores precedidos cada uno de ellos por uno dos o más cilindros descargadores ambos da accionamiento variable respondiendo a las caracteristicas de la máquina en lo que afecte a la transmisión de movimiento y a las distintas partes que le integran. todo ello con la finalidad de que el algodón experimente un cardado inicial antes de pasar a la acción de los chapones de la máquina a fin de mejorar con ello suS condiciones de uniformidad en el grueso del velo que se forma de regularidad en la distribución de las fibras que lo integran y de paralelismo mútuo entre las mismas.
Patent ES-197714-A1 (ES)
Title: Un dispositivo compensador para embarcaciones a vela
Filed: 1951-05-04
Abstract: En una embarcación de vela un dispositivo de contrapeso capaz de ser montado sobre la borda y que puede moverse ajustablemente sobre ella transversalmente a la embarcación en la medida requerida para contrarrestar la tendencia del barco a escorar a sotavento cuando se ciñe al viento o cuando está con el viento de través.
Patent ES-254059-A1 (ES)
Title: Fluorinated steroids
IPC: C07J71/00
Filed: 1959-12-09
Abstract: The invention comprises a compound having the formula: <FORM:0933867/IV(a)/1> wherein -C1-C2 and -C4-C5- are -CH2-CH2- or -CH=CH- -C9-C11- is <FORM:0933867/IV(a)/2> different and are hydrogen atoms, alkyl radicals, alkaryl radicals, aryl radicals, cycloalkyl radicals or heterocyclic radicals or taken together are cycloalkyl or heterocyclic radicals and Y is hydrogen, fluoro, OH or OR, in which R is a lower alkanoyl radical, a tetrahydropyran-2-yl-oxy radical or a tetrahydrofuran-2-yl-oxy radical, and the preparation thereof by treating a steroid of formula I lacking one or more of the above specified substituents or structures in accordance with one or more of the following reactions performed in any desired order (1) forming the D 1 and/or D 4 unsaturation by use of a dehydrogenating agent such as SeO2 or by use of a microorganism such as the Nocardia type (2) treating the 9,11-oxide with HF preferably in a suitable inert solvent to form the 9a -fluoro-11b -hydroxy steroid, and, if desired, oxidising the 11-hydroxy to 11-keto at any time in the reaction sequence (3) reacting the 16a -17a -dihydroxy steroid in the presence of an acidic agent with a carbonyl compound <FORM:0933867/IV(a)/3> wherein R1 and R11 are as defined above (4) introducing the 6a -fluoro atom by treating the corresponding 5a ,6a -epoxy steroid with HF and then dehydrating (5) where the 6a -mono-fluoro compounds are prepared forming the 11b -hydroxy group microbiologically, employing for example Botrytus cinerea. The 16a ,17a -dihydroxy steroid may be obtained by treating the corresponding 17a -hydroxy steroid with an organism such as Streptomyces roseochromogenus, Streptomyces viridus, Streptomyces olivaceous, and Streptomyces argenteolus.
Patent ES-269566-A1 (ES)
Title: Process for improving the workability of a high molecular weight polybutadiene
IPC: C08F136/06
Filed: 1961-08-04
Abstract: A mineral oil is added to a solution of a polybutadiene having a molecular weight in excess of 200,000 and cis.-1,4-enchainment and the solvent removed. The mineral oil may be added at the end of polymerization in hydrocarbon solution in the presence of a compound of a Group VIII metal and an organometallic halide. The mineral oil may be an aromatic oil a benzenic or a naphthenic oil and may be added in amount between 35 and 40 parts per 100 of polymer.
Patent ES-271521-A1 (ES)
Title: Manufacture of -methylmercaptopropionic aldehyde
IPC: C07C325/00
Filed: 1961-10-26
Abstract: b -Methylmercaptopropionic aldehyde is produced by reacting acrolein with an excess of methylmercaptan at -30 DEG to +50 DEG C. in the presence of a cobalt salt of an organic acid. The reaction, which may be performed at atmospheric pressure, is preferably performed employing an acrolein to methymercaptan molar ratio of less than 1 : 1.6, but above 1 : 1, and in the presence of less than 5% by weight of water or under anhydrous conditions. The cobalt salt may be used alone or on an inert carrier and, preferably, is employed as 0.1 to 0.5% by weight of the weight of acrolein. In a continuous process the first runnings from the distillation of the reaction product may be returned to the reaction vessel to act as a moderator in the reaction of the invention. The examples relate to the use of cobalt acetate, naphthenate and methylmercaptide as catalyst. Specification 687,483 is referred to.
Patent ES-302710-A1 (ES)
Title: Flintless gas-fueled lighter
IPC: F23Q2/30
Filed: 1964-07-31
Abstract: The gas in a lighter is ignited by a charge of hydrogen peroxide fed to a catalyst in the gas stream. Initial depression of the lever 19 (arrow F) causes the arms 18 to move the piston 17, peroxide container 1 and piston 12 as a unit downwardly to open the valve 8 on the butane or other gas container 5 thereby allowing gas to pass through conduits 13, 14 and 16 to the burner 2. Further depression of the lever 19 causes piston 17 to compress the resilient container 1 to bring parts 31, 32 to enable a charge of peroxide to be fed via conduits 34, 35 and tube 4 to a catalyst pellet in the burner 2 adjacent the gas outlet. When the lever 19 is in the position shown the peroxide container 1 is vented to atmosphere and the gas container valve is closed.
Patent ES-335566-A1 (ES)
Title: Rotary device
IPC: B66D1/02
Filed: 1967-01-12
Abstract: A load balancing reel comprises a grooved drum 16 to which a torque is applied by a load on the cable 26, and interchangeable spring motors 83, 83A, 83B which act in parallel to oppose and balance the said torque. The drum 16 which is freely rotatable on a shaft 17, is conical such that as the cable 26 is payed out, the torque applied to the drum increases in proportion to the increased tension in the spring motors as the springs thereof are wound up. The motor 83 adjacent the drum 16 comprises a spring 138 having its inner end 136 connected to the shaft 17 via collars 132, 133 pinned to a stub shaft 123, which is in square peg engagement at 68 with the shaft 17. The outer end of the spring 138 is connected to the drum 16 via a spring retainer housing 116 and a hub 44. The outer end of the spring 138 is connected to the housing 116 via a pawl 143 pivoted on a shaft 118 of the housing. The spring 138 holds the pawl downwardly normally but if the spring 138 breaks, a coil spring on the shaft 118 moves the pawl 143 outwardly to engage ratchet teeth on the outer casing of the apparatus to arrest the drum 16 in the paying out direction. A star-wheel mechanism 71, 78 between the drum 16 and the apparatus casing limits the number of rotations which the drum 16 is permitted to make. Fine adjustment of the initial spring tension is effected by a manual worm drive adjuster 66, 63, 61 which rotates the shafts 17 and 123. Further spring motors 83A, 83B &c. are added in parallel to the motor 83 to facilitate the balancing of a large range of loads. An adjustable friction brake 56, 57, 58 is provided between the drum 16 and the apparatus casing. In another embodiment the inner end of the spring 138 is connected to the hub 44 and the outer end of the spring is secured to the apparatus casing 84.
Patent ES-340599-A1 (ES)
Title: Web winding
IPC: B65H19/26
Filed: 1967-05-16
Abstract: Apparatus for making a number of small rolls 16, Fig. 1, from a supply roll 10 of sheet material, comprises a support roller 14 over which the web 11 passes, with means 23 for lifting a transverse strip of the web from the roller 14 and applying adhesive to the strip, and with means whereby during further movement of the web the adhesive strip is moved further outwardly from the roller 14 into contact with a rotating core on a mandrel 15 at a pick-up position 19, at which position a knife 24, Fig. 15, severs the web in advance of the strip. Cores are carried by mandrels 15 on a rotary carrier 18 which is indexed to move one core to a winding position 20 and a succeeding core to the pick-up position 19. The adhesive-applying device (see Division D1) comprises a plate 22 vertically-reciprocating in an adhesive container 21 so that during its downward movement its bottom edge picks up a metered amount of adhesive which may be transferred either directly to the web or indirectly through a roller with a radial protuberance (Fig. 7). Fixed to a shaft 67 situated within the roller 14 are arms 66 carrying the knife 24 and a resilient web-support member 23. At the requisite time, the shaft 67 is caused by a spring 78 to rotate so as to move the support 23 outwardly to a position where the strip of web on the support picks up adhesive from the plate 22. In this position of the shaft 67, the knife edge is level with the periphery of roller 14. As the web continues to move forward, the outward movement of the support 23 and knife 24 continues until at the pick-up position 19, the support 23 presses the adhesive strip against a core and the knife 24 severs the web in advance of the strip. To operate the shaft 67, an arm 70, Fig. 15, attached to the shaft carries a hooked part 80 normally engaged by a spring-urged latch 79 mounted on the end of the roller 14 so as to hold the support 23 and knife 24 within the surface of the roll. When a new roll 16 is to be started, an electromagnet is energized to move a dog 86 axially into the path of the latch 79 so that during the rotation of the roll, the latch is moved away from the hook 80. Movement of the shaft 67 under the action of spring 78 is now controlled by the engagement of a follower 73 with a fixed cam 76 so as to effect the movements of the support 23 and knife 24 as already described.