baber/WOPTO huggingface dataset:
Patent NZ-564607-A (NZ)
Title: Process for manufacturing vaccines comprising mixing a saccharide, protein carrier and a carbodiimide wherein one of the agents is added to the mixture over a defined period of time
Inventor: BIEMANS RALPH LEON
IPC: A61K39/095
Filed: 2006-06-23
Abstract: Disclosed is a method of making an immunogenic composition comprising conjugating a saccharide to a protein carrier using carbodiimide condensation chemistry, wherein the saccharide comprises, or has been derivatised to comprise, amino and/or carboxyl groups, and wherein the protein carrier comprises, or has been derivatised to comprise, amino and/or carboxyl groups, comprising the steps of: I) if the protein carrier comprises both amino and carboxyl groups and the saccharide comprises either amino or carboxyl groups: a) mixing the saccharide and aliquot of carbodiimide required to perform the conjugation, and b) adding the aliquot of protein carrier required over a period of 35 seconds to 6 hours; II) if the saccharide comprises both amino and carboxyl groups and the protein carrier comprises either amino or carboxyl groups: a) mixing the protein carrier and aliquot of carbodiimide required to perform the conjugation, and b) adding the aliquot of saccharide required over a period of 35 seconds to 6 hours; III) if the saccharide comprises both amino and carboxyl groups and the protein carrier comprises both amino and carboxyl groups: a) mixing the protein carrier and saccharide, and b) adding the aliquot of carbodiimide required to perform the conjugation over a period of 35 seconds to 6 hours. Further disclosed is an immunogenic composition or vaccine obtained by the method of as described above, wherein the saccharide is a bacterial capsular saccharide derived from a bacterium selected from a list consisting of: N. meningitidis serogroup A, B, C, W135 or Y, Streptococcus pneumoniae serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F or 33F, Group B Streptococcus group la, Ib, II, III, IV, V, VI, or VII, Staphylococcus aureus type 5, Staphylococcus aureus type 8, Salmonella typhi (Vi saccharide) or Vibrio cholerae, or wherein the saccharide is a bacterial lipooligosaccharide or lipopolysaccharide derived from a bacterium selected from a list consisting of: N. meningitidis, H. influenzae, E. coli, Salmonella or M. catarrhalis, and wherein an effective dose of the saccharide-protein conjugate is formulated with a pharmaceutically acceptable excipient.
Patent NZ-566387-A (NZ)
Title: Method to predict or monitor the response of a patient to an ErbB receptor drug by screening for mutations in an ErbB receptor
Inventor: NISHIO KAZUTO
IPC: C12Q1/68
Filed: 2005-10-20
Abstract: Disclosed is an ex vivo method for predicting the response of a patient to an ErbB receptor drug comprising detecting one or more mutations in an ErbB receptor wherein said method comprises the steps of:- (a) providing a bio-fluid sample from a patient; (b) extracting DNA from said sample; (c) screening said DNA for the presence of one or more mutations in the receptor using PCR and one or more techniques selected from the group consisting of: Single Stranded Conformation Polymorphism (SSCP); Restriction Fragment Length Polymorphisms (RFLPs); WAVE; Real-time PCR, Amplification Refractory Mutation system (ARMS); and probes in combination with ARMS wherein said probes comprise a single-stranded bi-Iabelled fluorescent sequence held in a hairpin-loop conformation by complementary stem sequences on the 5' and 3' ends of the probe, further comprising a fluorescent reporter dye attached to the 5' end and a quencher molecule attached to the 3' end, and wherein the hairpin loop is linked to the 5' end of a primer via a PCR blocker; and (d) predicting the response of a patient to an ErbB receptor drug based on the presence or absence of a mutated allele encoding said ErbB receptor.
Patent NZ-566714-A (NZ)
Title: Sock having terry loops in the welt band to improve comfort
Inventor: CARMELI YAEL
IPC: A41B11/04
Filed: 2008-03-14
Abstract: Disclosed is a sock (10) which includes a toe portion (12), a tubular body portion (20) and a heel and ankle portion (14). A leg engaging portion (22) extends upwardly from the heel and ankle portion and has an opening (24) for inserting a foot into the sock. In use the opening sits around the wearer's leg or ankle. The sock further includes a welt band (28) which is integrally knitted at or adjacent the opening and is formed using stitching which differs from the rest of the rest of the leg engaging portion. The welt band includes a plurality of terry loops (32) integrally knitted in the welt band and only projecting from the inside surface of the sock to minimise the marking in the wearerÆs leg or ankle from the welt bandÆs compression.
Patent NZ-573987-A (NZ)
Title: Improvements in and relating to sign bases
Inventor: EVANS DARRYL MAURICE
IPC: E01F9/70
Filed: 2008-12-23
Abstract: A sign base is disclosed. The sign base includes a post-support for supporting a sign post having at least three pivotal leg connections, and at least three legs pivotally connected to the leg connections. Each leg is independently rotatable about a pivot axis so that it is capable of extending outwardly from the post-support, or retracting inwardly towards the post-support. In profile, the pivot axis of each pivotal leg connection is angled with respect to the longitudinal axis of the post support.
Patent NZ-575368-A (NZ)
Title: Dimensionally stable sterilizable coextruded film for aseptic packaging
Inventor: BEKELE SOLOMON
IPC: B32B27/32
Filed: 2006-11-17
Abstract: Disclosed is an aseptic package which comprises: a) a sterilised food product, and b) a sterilised pouch in which the sterilised food product is disposed, the sterilised pouch comprising a coextruded multilayer film comprising i) a core layer comprising ethylene vinyl alcohol copolymer; ii) two intermediate layers each comprising polyamide (such as nylon 6, or a blend of an amorphous polyamide having a glass transition temperature of at least 80°C, and a semicrystalline polyamide); iii) a first outer layer comprising amorphous cyclic olefin copolymer (such as an ethylene norbornene copolymer); iv) a second outer layer comprising amorphous cyclic olefin copolymer or olefinic copolymer; and v) two tie layers each adhering an intermediate layer to a respective outer layer.
Patent NZ-579416-A (NZ)
Title: Method for reducing side effects of retinoic acid therapy by administration of a nicotinic acid alkyl ester such as myristyl nicotinate or palmitoyl nicotinate
Inventor: JACOBSON ELAINE L
IPC: A61K31/21
Filed: 2008-02-27
Abstract: Disclosed is the use of a nicotinic acid alkyl ester to alleviate a side effect of retinoic acid therapy, or to improve efficacy without interfering with the efficacy of the retinoic acid therapy. Also disclosed is the use of a nicotinic acid alkyl ester to treat a disease or disorder responsive to increased expression of caspase 14 and filaggrin.
Patent NZ-579442-A (NZ)
Title: Co-crystals of VX-950 (telaprevir) and other components, and pharmaceutical compositions comprising the same
Inventor: CONNELLY PATRICK R
IPC: A61K31/497
Filed: 2008-02-27
Abstract: Disclosed is a co-crystal comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide (Telaprevir) and 4-hydroxybenzoic acid.
Patent NZ-580205-A (NZ)
Title: 2-Amido-4-aryloxy-1-carbonylpyrrolidine derivatives as inhibitors of serine proteases, particularly HCV NS3-NS4A protease
Inventor: PERNI ROBERT B
IPC: A61K38/00
Filed: 2004-09-07
Abstract: Disclosed is an amino acid derivative including a pyrrolidine, of formula I, where the substituents and variables are as defined in the specification. Also disclosed is the use of the compound for inhibiting a serine protease, such as HCV NS3 protease. Also disclosed is the use of the compound to treat an HCV (hepatitis C virus) infection.
Patent NZ-581329-A (NZ)
Title: Composite Disposable Bed Linen Package
Inventor: PILLAY MOGAMBIREE
IPC: A47G9/02
Filed: 2009-11-23
Abstract: This discloses a composite disposable bed linen package comprising a fitted bottom sheet 2, with an integral top sheet 6 made from a single piece of cloth, and an attached pillow case 5 with seams 4 enabling the pillow to pivot. The package is secured to the mattress 3 by pre-formed pockets at the head and foot end without zips, clips, ties or hooks and loop fasteners. (61) Addition to 579291
Patent NZ-583699-A (NZ)
Title: Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
Inventor: ZHANG YUEGANG
IPC: A61K31/454
Filed: 2008-08-29
Abstract: Disclosed is a co-crystal comprising a compound of formula I (commonly known as telaprevir or VX-950) and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid.
Patent NZ-584253-A (NZ)
Title: Triple density gel heel cups with a reinforcement component in the gel layer
Inventor: GRANGER DAVID BRADLEY
IPC: A43B23/08
Filed: 2009-01-12
Abstract: A triple density heel cup comprises a generally heel-shaped substrate having a length extending from a heel back wall to a front border 3. The front border 3 is positioned to underlie a portion of the arch area of the bottom of a wearer's foot when in use. The heel-shaped substrate comprises a structural gel layer 1 having a foot receiving surface and a shoe side surface. The foot receiving surface has a flat area which is adapted to underlie the bottom of a wearer's foot in use and an upwardly extending integral wall which is adapted to lie adjacent to the back and sides of the wearer's heel in use. The integral wall has a back apex of maximum height and tapers down in height from the back apex toward the front border 3. The shoe side surface defines a channel formed in the structural gel layer 1, where the channel is adapted to receive a reinforcement component 6. A reinforcement component 6 is secured to the structural gel layer 1 in the channel, where the reinforcement component 6 comprises a denser material than the structural gel layer 1 and has a curvature complementary to the upwardly extending integral wall in the area of the back of the heel. The curvature descends toward the base of the heel cup and then extends along the side of the heel cup and forward to the front border 3. The shoe side surface further defines a heel cushion area. A heel cushion 7 is secured to the structural gel layer 1 in the heel cushion area.
Patent NZ-584726-A (NZ)
Title: Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
Inventor: ROTHE MIKE
IPC: A61K33/24
Filed: 2008-09-26
Abstract: Disclosed is an isolated antibody or fragment thereof that specifically binds HB-EGF, comprising light chain complementary determining regions (CDRLs) CDRL1, CDRL2 and CDRL3 and heavy chain complementary determining regions (CDRHs) CDRH1, CDRH2 and CDRH3, wherein the isolated antibody or antibody fragment comprises a) a CDRL1 of SEQ ID NO: 207, a CDRL2 of SEQ ID NO: 225, a CDRL3 of SEQ ID NO: 257, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 323 and a CDRH3 of SEQ ID NO: 361; or b) a CDRL1 of SEQ ID NO: 210, a CDRL2 of SEQ ID NO: 221, a CDRL3 of SEQ ID NO: 260, a CDRH1 of SEQ ID NO: 292, a CDRH2 of SEQ ID NO: 320 and a CDRH3 of SEQ ID NO: 362; or c) a CDRL1 of SEQ ID NO: 213, a CDRL2 of SEQ ID NO: 230, a CDRL3 of SEQ ID NO: 263, a CDRH1 of SEQ ID NO: 293, a CDRH2 of SEQ ID NO: 324 and a CDRH3 of SEQ ID NO: 364.
Patent NZ-595071-A (NZ)
Title: Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
Inventor: HIROTA TAKAFUMI
IPC: A61K9/14
Filed: 2010-03-12
Abstract: Patent No. 595542 Disclosed is a tablet containing (1) 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a salt thereof, (2) a low substituted hydroxypropyl cellulose or croscarmellose sodium and (3) a binder, wherein the amount of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a salt thereof contained in therein is 50 to 95% of the mass of the tablet.
Patent NZ-606669-A (NZ)
Title: Full form ship's hull with reduced wave making resistance
Inventor: DINHAM-PEREN THOMAS
IPC: B63B1/06
Filed: 2011-08-09
Abstract: Disclosed is a method and ship with a full form hull where the hull has reduced drag and wavemaking resistance and improved efficiency by moving the position of the forward shoulder (3) forwards and upwards to obtain at least a partial antiphase interaction between the shoulder wave and bow wave, sufficient to prevent the bow wave from breaking at its second crest. The vessel has steering means, propulsion means, a service speed, a length between perpendiculars (LPP), a length axis, and a section area defined as the transverse sectional area of the hull below the waterline in a design condition. The submerged portion of the hull in the design condition comprises a forebody portion, an afterbody portion, and a midbody portion of maximum section area arranged between the forebody portion and the afterbody portion. The forebody portion comprises a bow and a forward shoulder aft of the bow, the midbody and forebody portions having substantially positive curvature as represented on a section area curve of the hull. The method includes positioning the forward shoulder to obtain at least a partial antiphase interaction between a shoulder wave generated by the shoulder and a bow wave generated by the bow at the service speed, the interaction reducing the amplitude of the bow wave sufficiently to prevent the bow wave from breaking at a second crest thereof. A forwardly tapered portion is arranged between the forward shoulder and the midbody portion, the forwardly tapered portion forming part of the forebody portion.
Patent NZ-608721-A (NZ)
Title: Crystalline oxalate salts of a diamide compound
Inventor: THALLADI VENKAT
IPC: C07D401/12
Filed: 2011-09-29
Abstract: Disclosed are crystalline oxalate salts of biphenyl-2-ylcarbamic acid 1-(2-{ [4-(4-{ [(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-methyl} phenylcarbamoyl)butyl]methylcarbamoyl} ethyl)piperidin-4-yl ester; wherein the crystalline oxalate salt is selected from: (a) an isopropanol solvate characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2theta values of 11.66±0.20, 15.75±0.20, 19.55±0.20, 23.00±0.20 and 23.45±0.20; and (b) a hydrate characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2theta values of 15.32±0.20, 16.90±0.20, 19.25±0.20 and 23.73±0.20. Also disclosed are compositions containing the crystalline oxalate salt; and use of the salt to treat a pulmonary disorder; and to processes for preparing the crystalline oxalate salt.
Patent NZ-608909-A (NZ)
Title: Direct smelting process
Inventor: DRY RODNEY JAMES
IPC: C22B5/10
Filed: 2011-09-15
Abstract: The disclosure relates to a direct smelting process that supplies a metalliferous material, a solid carbonaceous feed material and an oxygen-containing gas into a direct smelting vessel (Fig. 1) containing a molten bath of metal and slag to produce molten metal, molten slag and an off-gas. The process conditions are controlled such that the molten slag has a viscosity in a range of 0.5 – 5 poise at the operating temperature range for the process. The metalliferous material may be an iron-containing material such as iron ore, and the temperature range may be 1400 – 1550 degrees C.
Patent NZ-610075-A (NZ)
Title: Cxcr2 binding polypeptides
Inventor: BRADLEY MICHELLE
IPC: C07K16/28
Filed: 2011-11-07
Abstract: Disclosed is an isolated polypeptide comprising a first immunoglobulin single variable domain and a second immunoglobulin single variable domain, wherein each domain binds to the chemokine receptor CXCR2, and wherein the first immunoglobulin single variable domain binds a linear peptide consisting of the sequence of amino acids set forth in SEQ ID NO: 7 (MEDFNMESDSFEDFWKGED) and the second immunoglobulin single variable domain does not bind to said linear peptide. Also disclosed is the use of said polypeptide in the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease (COPD) or exacerbations of COPD.
Patent NZ-621749-A (NZ)
Title: A catheter having a pressure activated splittable feature
Inventor: MOULTON WILLIAM G
IPC: A61M25/00
Filed: 2012-08-07
Abstract: A catheter (114,214,314,414) having a catheter body (220,320,420) with a lumen (322,422) and a distal lumen opening (242,342,442). The catheter’s lumen extends through the catheter body along a longitudinal axis of the catheter body. A splittable feature (250,350,450) is formed within a wall of the catheter body.
Patent NZ-625402-A (NZ)
Title: Antibacterial tylosin derivatives and methods for their preparation
Inventor: FROYMAN ROBRECHT
IPC: C07H17/08
Filed: 2012-11-21
Abstract: The present disclosure relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (I); a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal. One example of the marcolide derivative is 20-(4-phenyl-1H-1,2,3-triazol-1-yl)-20-deoxo-23-(4-butyl-1H-1,2,3-triazol-1-yl)-23-deoxy-5-O-mycaminosyltylonolide.
Patent NZ-626989-A (NZ)
Title: Boom mountable robotic arm
Inventor: DEVINE CLIFFORD W
IPC: H02G1/02
Filed: 2012-12-10
Abstract: A boom mountable robotic arm for includes a beam pivotally mounted on a boom mounting adaptor, at least two electrically insulated support posts mounted to and spaced apart along the beam, and at least a first rotation coupling and a plurality of second rotation couplings. The first rotation coupling provides pivotal mounting of the beam on the boom mounting adaptor so as to provide selectively controllable rotation of the beam in a substantially vertical plane. The second rotation couplings provide selectively controllable rotation of the electrically insulated support posts about corresponding second axes of rotation between a retracted position substantially laid flush along the beam and a pick-up position ready to receive a conductor being supported. An actuated scissor linkage is mounted to the beam and the boom mounting adaptor for selectively adjusting an angular position of the beam relative to the boom mounting adaptor.
Patent NZ-627472-A (NZ)
Title: Grapple carriage for logging
Inventor: JONES GARY LEE
IPC: B66C11/16
Filed: 2014-07-15
Abstract: Disclosed is a grapple carriage grapple carriage for attaching to a cable suspended above ground and for picking up one or more logs and moving the one or more logs along the path of the cable, the carriage comprising: a body having a coupler for coupling the body to the cable and enabling the carriage to move along the cable; and at least two articulated arms extending from the body, each arm having a distal end to which is attached a grapple adapted to pick up, hold and release the one or more logs. Each arm comprises a vertical movement actuator to control vertical movement of the arm, and a horizontal movement actuator to control horizontal movement of the arm. The coupler may comprise one or more grooved wheels adapted to movably engage with the cable. Each wheel may be rotatably attached to a pair of shivs that are adapted to suspend the grapple carriage from the cable. Each arm may be pivotably connected to the body via a boom extending from the body, and each may be formed from a plurality of arm segments (for example, 2, 3 or 4 segments) rotatably connected in series. The segments are preferably connected by ball joints, but may alternatively be connected by any other form of rotating joint. The vertical and horizontal movement actuators of each arm are located at or near a first end of the arm that is proximal to the body. The vertical and horizontal movement actuators each preferably include an hydraulic ram. The distal end of each arm may comprise a grapple actuating means for opening and closing jaws of the grapple, and the grapple actuating means may comprise an hydraulic ram. The grapple carriage comprises a control system to enable the carriage to be controlled remotely. The control system may comprise one or more signal transmitters and receivers. Movement of each arm and each grapple is preferably controlled by hydraulic rams powered by electric motors. Preferably, each arm is able to extend from the body at a distance of approximately 4 metres.
Patent NZ-700680-A (NZ)
Title: Device for dispensing charges of a fluid
Inventor: VAN DER HULST WILLEM
IPC: G01F11/06
Filed: 2013-04-17
Abstract: The invention relates to an improved device (1) for dispensing charges of a fluid and a system comprising such a device. The device (1) according to the invention comprises a housing (2) provided with a first inlet (3) arranged for allowing a first flow of a fluid to be proportioned to flow into the device; a second inlet (4) arranged for allowing a second flow of said fluid to flow into the device; a first fluid communication means (9) that is arranged for establishing fluid communication between the first inlet (3) and a first chamber (6); a second fluid communication means (10) that is arranged for establishing fluid communication between the second inlet (4) and the first chamber (6); a piston (11) that is provided in the first chamber (6) and is arranged for keeping the first and the second flows separated; a plunger (13) that is provided in a second chamber (14) and is arranged for establishing alternately a first charge out of the first flow and a second charge out of the second flow; an outlet (20) for said first and second charges; and a third (17), a fourth (18) and a fifth (19) fluid communication means that are arranged for enabling fluid communication between the first (6) and the second (14) chambers and the outlet (20), wherein the third (17), the fourth (18) and the fifth (19) fluid communication means, the piston (11) and the plunger (13) are arranged for alternately dispensing the first and the second charges at the outlet (20) of the device. In this way, the invention provides a device that has a simpler construction than prior art devices in terms of parts required for dispensing a charge of fluid at the outlet for lubricating a point, e.g. a bearing. Therefore, the device according to the present invention is more robust and more reliable than devices known from the prior art.
Patent NZ-713562-A (NZ)
Title: Tube support
Inventor: GEOFFREY BRYAN MACKNEY
IPC: A62B35/00
Filed: 2014-07-07
Abstract: A support 100 for supporting a portion, external to a patient, of a tube partly embedded in the patient, the support 100 including a torso embracing portion 10 for embracing a torso of the patient, and one or more tube holding portions 13a for holding the tube and being fixable to, or part of, the torso embracing portion, a shoulder strap, and a connection arrangement by which the shoulder strap is attached or attachable to the torso embracing portion 10, and which is laterally relocatable across the patient’s back.
Patent NZ-714347-A (NZ)
Title: Method of treating intracellular infection
Inventor: PELLEGRINI MARC
IPC: C07D209/04
Filed: 2014-06-25
Abstract: The present invention provides a method of treating an intracellular infection in a subject wherein the method comprises administering to the subject an IAP antagonist. In certain embodiments the IAP antagonist is a Smac mimetic. In certain embodiments, the Smac mimetic is birinapant. In certain embodiments, the invention provides for the use of an monovalent cIAP1 antagonist or bivalent cIAP1 and cIAP2 antagonist in the manufacture of a medicament for the treatment of a persistent hepatitis B virus (HBV) intracellular infection in which tumour necrosis factor (TNF) is produced in a subject.