Patent SG-11201901197P-A (SG)
Title: Amino-pyrrolopyrimidinone compounds and methods of use thereof
Inventor: BATES CRAIG
IPC: C07D487/04
Filed: 2017-08-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT omit VIII °nolo III uall 11°1°11mm oimIE (10) International Publication Number WO 2018/039310 Al (51) International Patent Classification: C07D 487/04 (2006.01) A61K 31/519 (2006.01) CO7D 405/12 (2006.01) (21) International Application Number: PCT/US2017/048152 (22) International Filing Date: 23 August 2017 (23.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/378,868 24 August 2016 (24.08.2016) US 62/378,871 24 August 2016 (24.08.2016) US 62/378,872 24 August 2016 (24.08.2016) US (71) Applicant: ARQULE, INC. [US/US]; One Wall Street, Burlington, Massachusetts 01803 (US). (72) Inventors: BATES, Craig; 53 Tenney Road, Pelham, New Hampshire 03076 (US). EATHIRAJ, Sudharshan; 24 Ptarmigan Drive, Shrewsbury, Massachusetts 01545 (US). INAGAKI, Hiroaki; c/o DAIICHI SANKYO COM- PANY, LIMITED, 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo 103-8426 (JP). LAPIERRE, Jean-Marc; 1 Alexan- dria Drive, Pelham, New Hampshire 03076 (US). MO- MOSE, Takayuki; c/o Daiichi Sankyo Company, Limit- ed, 3-5-1, Nibonbashi Honcho, Chuo-ku, Tokyo 103-8426 (JP). NAKAYAMA, Kiyoshi; c/o Daiichi Sankyo Compa- ny, Limited, 3-5-1, Nihonbashi Honcho, Chuo-Ku, Tokyo 103-8426 (JP). ODAGIRI, Takashi; c/o Daiichi Sankyo Company, Limited, 3-5-1, Nihonbashi Honcho, Chuo-Ku, Tokyo 103-8426 (JP). OTA, Masahiro; c/o Daiichi Sankyo Company, Limited, 3-5-1, Nihonbashi Honcho, Chuo-Ku, Tokyo 103-8426 (JP). OTA, Yusuke; c/o Daiichi Sankyo Company, Limited, 3-5-1, Nihonbashi Honcho, Chuo-Ku, Tokyo 103-8426 (JP). SHIBATA, Yoshihiro; c/o Dai- ichi Sankyo Company, Limited, 3-5-1, Nihonbashi Hon- cho, Chuo-Ku, Tokyo 103-8426 (JP). TANDON, Manish; 51 Lovering Avenue, Framingham, Massachusetts 01701 (US). TSUNEMI, Tomoyuki; c/o DAIICHI SANKYO COMPANY, LIMITED, 3-5-1, Nihonbashi Honcho, Chuo- ku, Tokyo 103-8426 (JP). (74) Agent: PAVAO, Matthew et al.; Cooley LLP, 1299 Penn- sylvania Avenue, Suite 700, Washington, District of Colum- bia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) (54) Title: AMINO-PYRROLOPYRIMIDINONE COMPOUNDS AND METHODS OF USE THEREOF (57) : The application relates to a compound of Formula (I): or a pharmaceutically accept- able salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role. (I) O O cc C