Patent SG-11201408042Y-A (SG)
Title: Improved antagonist antibodies against gdf-8 and uses therefor
Inventor: APGAR JAMES REASONER
IPC: C12N15/13
Filed: 2013-06-12
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/186719 A1 (51) International Patent Classification: C07K16/00 (2006.01) A61K39/395 (2006.01) (21) International Application Number: PCT/IB2013/054810 (22) International Filing Date: 12 June 2013 (12.06.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/660,232 15 June 2012 (15.06.2012) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, New York 10017 (US). (72) Inventors: APGAR, James Reasoner; 9 Claremon Street, Apartment #2, Somerville, Massachusetts 02144 (US). MADER, Michelle Marie; 7A Spring Road, Arlington, Massachusetts 02476 (US). PARRIS, Kevin Delos; 187 Ledgewood Road, Apartment 212, Groton, Connecticut 06340 (US). (74) Agent: KLEIMAN, Gabriel L.; Pfizer Inc., 235 East 42nd Street, New York, New York 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.17(i)) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) [Continued on next page] (54) Title: IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR FIG. 1*1 o\ T-H l> 00 T-H o CJ (57) Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of ex­ pression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders. WO 2013/186719 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll lllll lllll llll llll lllllll llll llll — with (an) indication(s) in relation to deposited biological — with sequence listing part of description (Rule 5.2(a)) material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii))