baber/WOPTO huggingface dataset:
Patent ES-2063400-T3 (ES)
Inventor: HOFNER KARL
IPC: H01R11/01
Filed: 1991-05-16
Granted: 1995-01-01
Abstract: It consists of a connecting tube (1) having a tube insert (30) which is supported coaxially therein via insulating means (46...49) and has connecting rails (31). Connecting means (4...6) for the parts (7) of the operating means are fitted on the outer surface of the connecting tube (1) for the first potential, on the end (2) on the installation side, and connecting bolts (14...21) for the partial cables, which are arranged to have a low stray field, of a cable harness which carries DC current is fitted on the end (3) on the cable side, said items being fitted in an annular shape. Connecting means (32...34) for the parts (9) of the operating means are fitted on the connecting rails (31) for the second potential, on the end on the installation side, and connecting bolts (37...44) for the partial cables are fitted on the end on the cable side, said items being fitted radially in the form of a star. A number of connecting bolts (37...40) on the connecting rail (31) are preferably constructed in the form of a column and are led out as far as the outer surface via segment-like cut-outs (22...25) on the end (3) on the cable side of the connecting tube (1). <IMAGE>
Patent ES-2069122-T3 (ES)
Title: Procedimiento para la obtencion de 2-cloro-5-metil-piridina.
Inventor: KAUFMANN DIETER DR
IPC: C07D213/61
Filed: 1991-06-11
Granted: 1995-05-01
Abstract: SE PONE A PUNTO UN NUEVO PROCEDIMIENTO PARA LA PRODUCCION DE 2-CLORO-5-METIL-PIRIDINA A PARTIR DE 1-OXI-3-METIL-PIRIDINA. EL NUEVO PROCEDIMIENTO SE CARACTERIZA PORQUE LA REACCION SE LLEVA A CABO EN PRESENCIA DE UNA SUSTANCIA DE CLORACION DE FORMULA GENERAL (III) EN LA QUE R ELEVADO 1 ES ALQUILO, HALOGENOALQUILO, CICLOALQUILO, UN ARILO EVENTUALMENTE SUSTITUIDO, NR (AL CUADRADO) R ELEVADO 3 O OR ELEVADO 4, EN DONDE R (AL CUADRADO) Y R ELEVADO 3 SIGNIFICAN POR SEPARADO ALQUILO, CICLOALQUILO O ARILO O, JUNTOS, ALCANODIILO O OXAALCANODIILO, R ELEVADO 4 SIGNIFICA ALQUILO, CICLOALQUILO O UN ARILO EVENTUALMENTE SUSTITUIDO, EN PRESENCIA DE UN COMPUESTO BASICO ORGANICO DE NITROGENO Y EN PRESENCIA DE UN DILUYENTE, A TEMPERATURAS ENTRE -20 C Y +150 C, SIENDO ELABORADO A CONTINUACION EL PRODUCTO DE REACCION DE LA MANERA HABITUAL. LA 2-CLORO-5-METIL-PIRIDINA ES UN PRODUCTO INTERMEDIO PARA LA PRODUCCION, ENTRE OTROS, DE FARMACOS O TAMBIEN DE INSECTICIDAS.
Patent ES-2082047-T3 (ES)
Inventor: CROCE CLAUDIO
IPC: H01R24/38
Filed: 1991-06-25
Granted: 1996-03-16
Abstract: A thermic protection device for vehicle lighters in which the electric contact holder base (16) is provided with a first bimetallic lamina (15) for thermic protection against superheating that causes a short circuit allowing the lighter to be reutilized. The base (16) is fitted with a second bimetallic lamina (18) for thermic protection that remains abut against the resistor (12) of the lighter's plug (10) when this is pressed into the base, maintaining the electric contact until at least the first lamina (15) is started up. <IMAGE>
Patent ES-2085412-T3 (ES)
Inventor: KOMIYAMA OSAMU
IPC: C12M1/26
Filed: 1991-12-20
Granted: 1996-06-01
Abstract: An instrument for measuring the activity of an enzyme or the activity of an enzymatic reaction-inhibiting substance, which comprises a thin tube section charged with a substrate gel for an enzymatic reaction and provided on one end thereof with a receptacle section for a sample liquid to be measured. <IMAGE>
Patent ES-2048554-T3 (ES)
Title: Metodo y aparato para seleccionar y formar ramos de flores.
Inventor: TAS ADRIANUS WILHELMUS
IPC: B65B27/00
Filed: 1991-03-27
Granted: 1994-03-16
Abstract: LA INVENCION SE REFIERE A UN METODO PARA SELECCIONAR Y FORMAR RAMOS DE FLORES (2), QUE INCLUYE SUSPENDER LAS FLORES POR SEPARADO EN ELEMENTOS DE SOPORTE INDIVIDUALES PARA CADA FLOR (3) QUE CIRCULAN EN UN PRIMER RECORRIDO CERRADO (1); SEGUN ATRAVIESAN DICHO RECORRIDO, SELECCIONAR LAS FLORES SEGUN UNA CARACTERISTICA POR LO MENOS, COMO LA LONGITUD DEL TALLO; DEPENDIENDO DE LA CARACTERISTICA SELECCIONADA TRANSFERIR LAS FLORES A LOS SEGUNDOS ELEMENTOS DE SOPORTE PARA LAS FLORES (11) CIRCULANDO EN EL SEGUNDO RECORRIDO (10); AGRUPAR LAS FLORES EN GRUPOS; Y RECOGER Y FORMAR EN RAMOS UNA SERIE DE GRUPOS. SEGUN LA INVENCION LOS ELEMENTOS DE SOPORTE INDIVIDUALES PARA FLORES SE MUEVEN ADYACENTES A UN PUNTO DE TRANSFERENCIA DESDE UNA POSICION DE TRANSPORTE A UNA POSICION DE TRANSFERENCIA EN UNA LINEA SUSTANCIALMENTE PERPENDICULAR AL PRIMER RECORRIDO, MIENTRAS DURANTE LA TRANSFERENCIA LOS SEGUNDOS ELEMENTOS DE SOPORTE PARA FLORES SE MANTIENEN ESTACIONARIOS Y ORIENTADOS EN LA DIRECCION DEL MOVIMIENTO DE LOS ELEMENTOS INDIVIDUALES DE SOPORTE PARA FLORES. LA INVENCION SE REFIERE ADEMAS A UN APARATO PARA APLICAR ESTE METODO.
Patent ES-2091283-T3 (ES)
Inventor: LAIGLE JEAN-CLAUDE
IPC: C07D405/06
Filed: 1991-05-10
Granted: 1996-11-01
Abstract: The invention concerns an isochromane derivative having the general formula I <CHEM> in which R1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group; R2 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group; R3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group;  R4 is selected from hydrogen or alkyl (1-4 C); A is a bond or an alkylene or alkylidene group with 1-6 carbon atoms; B is an alkylene or alkylidene group with 1-6 carbon atoms when Y is a bond, or B is an alkylene group with 2-6 carbon atoms when Y is a group selected from O, S, or NR5;  X is CH or N; and  R5 is selected from hydrogen or alkyl (1-4 C);  or a pharmaceutically acceptable salt thereof. The compounds can be used in the treatment of angina pectoris, cardiac dysrhytmias, cardiomyopathies, stroke, sudden death, and myocardial infarction.
Patent ES-2068486-T3 (ES)
Inventor: FIJNVANDRAAT JAN WILLEM
IPC: B66F7/04
Filed: 1991-08-29
Granted: 1995-04-16
Abstract: The invention relates to a vehicle lifting device comprising at least one column (2), with a vertically movable carriage (3) provided with a support (7) to which bearing arms (8) for supporting a vehicle are mounted for swivelling about a vertical swivel shaft (68) and drive means for moving the carriage (3) upward along the column (2). Each arm (8) is provided with an arresting for locking same in a selected swivel position, comprising a first tooth member (61) connected non-rotatably to the support (7), a second tooth member (69) connected non-rotatably to the arm (8), which tooth members (61,69) are provided with co-acting toothing (57,79) coaxially with the swivel shaft (68) and wherein at least one (69) of the tooth members (61,69) is mounted for axial disengagement from the other (61) by releasing means. At least at the height of the swivel shaft (68) the bearing arm (8) has a rectangular profile (58). The arresting is arranged in the interior of the hollow bearing arm (8), wherein the tooth member (69) connected non-rotatably to the bearing arm (8) is accommodated in a holder (69) with two parallel side walls (70,71) which lie slidably against two parallel vertical wall parts of the rectangular profile (58) of the bearing arm (8) and the releasing means engage onto this tooth member (69). <IMAGE>
Patent ES-2043463-T3 (ES)
Inventor: HOFMANN EUGEN
IPC: A61M25/00
Filed: 1991-06-26
Granted: 1993-12-16
Abstract: The dilatation catheter has a shaft which consists of two separately produced shaft portions. Both portions have a first lumen for a guide wire and a second lumen for a pressure liquid. The two portions overlap at a connection point and are preferably welded to one another at this point. The proximal portion consists of two coaxial tube portions and the distal portion consists of an extruded two-lumen tube piece. The proximal portion is stiffer than the distal portion, which permits an optimal adaptation to a non-straight course of a blood vessel. The dilatation catheter according to the invention is particularly suitable for the treatment of arterial occlusions, which are situated in or downstream of a vessel curve.
Patent ES-2071310-T3 (ES)
Inventor: WESTERMANN JURGEN
IPC: C07J1/00
Filed: 1991-05-08
Granted: 1995-06-16
Abstract: PCT No. PCT/DE91/00386 Sec. 371 Date Jan. 11, 1993 Sec. 102(e) Date Jan. 11, 1993 PCT Filed May 8, 1991 PCT Pub. No. WO91/17175 PCT Pub. Date Nov. 14, 1991.The new intermediate products of general formula I    <IMAGE>  I  in which R1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms, R2 stands for a hydrogen atom or a methyl group, R3 stands for a hydrogen atom, R4 stands for an acyloxy group with 1 to 4 carbon atoms in the acyl radical or R3 and R4 together stand for a keto-oxygen atom, are suitable in an excellent way for introducing a  DELTA 1 double bond in the steroid skelton with the simultaneous presence of a  DELTA 4 double bond, as well as a saturated carbonyl group, by clevage of hydrogen iodide with a base in an amidic solvent at elevated temperature. If R2 stands for a hydrogen atom, the A-ring is aromatized after the hydrogen iodide cleavage. For the production of a new intermediate products, special iodization processes, which partially also allow a stereoselective control of the iodization, are used.
Patent ES-2148150-T3 (ES)
Inventor: DELLA VALLE FRANCESCO
IPC: C07H15/10
Filed: 1991-05-16
Granted: 2000-10-16
Abstract: The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.
Patent ES-2085479-T3 (ES)
Title: Bastidor para caldera de lecho.
Inventor: SVENDSEN HARALD
IPC: F23C10/16
Filed: 1991-06-11
Granted: 1996-06-01
Abstract: LA PRESENTE INVENCION SE REFIERE A UNA ESTRUCTURA DE ARMADURA (11) PARA UN RECIPIENTE CON LECHO MONTADO VERTICALMENTE (2) EN UNA CENTRAL DE ENERGIA EN QUE EL INTERIOR DEL RECIPIENTE CON LECHO SE VE SOMETIDO A UNA PRESION INFERIOR A LA DEL ESPACIO CIRCUNDANTE. LAS PAREDES DEL RECIPIENTE CON LECHO (2) SE REFUERZAN A BASE DE EXTENDER HORIZONTALMENTE UNAS ARMADURAS CONTINUAS CIRCUNDANTES (12) CON ESQUINAS RIGIDAS. LAS ARMADURAS (12) ESTAN HECHAS PREFERENTEMENTE DE TROZOS DE VIGAS ESTANDAR. SE COLOCAN UNAS BARRAS ANTITORSION (28) PARA CADA ARMADURA (12) MEDIANTE BARRAS QUE SE FIJAN RIGIDAMENTE A UNA ARMADURA (12C) Y MONTADAS DE FORMA QUE SE PUEDAN MOVER AXIALMENTE EN UNA ARMADURA ADYACENTE (12B). HAY UNAS VIGAS AUXILIARES VERTICALES (31) CONECTADAS A LAS ARMADURAS QUE SE EXTIENDEN A TRAVES DEL ALMA DE LA VIGA DE LA ARMADURA, LO QUE PERMITE QUE LAS VIGAS AUXILIARES SE PUEDAN MOVER LIBREMENTE DE MANERA AXIAL A TRAVES DEL ALMA DE LA ARMADURA. HAY UNOS ELEMENTOS DISPUESTOS MEDIANTE UNAS GUIA (26) QUE HAY EN LA PARED (19) DEL RECIPIENTE CON LECHO PARA PREVENIR LA ROTURA DE LAS VIGAS SI ESTAS SE DOBLAN EN LA DIRECCION VERTICAL. LAS ARMADURAS INDIVIDUALES DESCANSAN SOBRE UNOS SOPORTES (39) Y SE PUEDEN MOVER DENTRO DE UNAS ABRAZADERAS (20) QUE HAY EN LA PARED DEL RECIPIENTE CON LECHO.
Patent ES-2101005-T3 (ES)
Title: Sistema fluido para la orientacion de una pulverizacion atomizada.
Inventor: RILEY MICHAEL FRANCIS
IPC: B05B7/08
Filed: 1992-12-01
Granted: 1997-07-01
Abstract: UN METODO Y APARATO PARA CAMBIAR LA DIRECCION DE UN FLUJO DE MATERIAL ATOMIZADO EN UN ESPACIO AMPLIO SIN OSCILACION MECANICA EN EL CUAL LA ATOMIZACION ANULAR SE LLEVA A CABO CON UN EFECTO DE GRADIENTE DE PRESION POR APLICACION DE UNO O MAS CHORROS DE GAS DE CONTROL DE FLUIDO.
Patent ES-2072089-T3 (ES)
Inventor: CLERICI MARIO GABRIELE
IPC: C07D301/06
Filed: 1992-08-01
Granted: 1995-07-01
Abstract: Process for producing olefin oxides by means of the reaction of an olefin with oxygen or air, in the presence of a catalyst constituted by titanium silicalite and a redox system comprising alkyl-anthrahydroquinone and alkyl-anthraquinone, with said reaction being carried out in a solvent mixture consisting of:   (a) one or more aromatic or alkyl-aromatic, mono- or polynuclear hydrocarbon(s) selected from among benzene, toluene, xylene, alpha-methyl-naphthalene or halogenated derivatives thereof, such as dichlorobenzene; (b) one or more polar organic compound(s) with boiling point comprised within the range of from 150 to 350 DEG C, and selected from among di-isobutyl-carbinol, di-isobutyl-ketone, methyl-cyclohexyl acetate, dimethyl phthalate, dibutyl phthalate, diethylhexyl phthalate and tributyl phthalate;   (c) a low molecular weight alcohol, preferably methanol.   <IMAGE>
Patent ES-2066578-T3 (ES)
Title: Composicion detergente liquida concentrada que contiene un agente secuestrante de tipo polifosfonato.
Inventor: GOFFINET PIERRE CHARLES EMILE
IPC: C11D1/02
Filed: 1992-06-05
Granted: 1995-03-01
Abstract: LA PRESENTE INVENCION SE REFIERE A UNA COMPOSICION DETERGENTE LIQUIDA CONCENTRADA -CONTENIDO EN AGUA < 10% EN PESO CONTIENE UN AGENTE SECUESTRANTE DE TIPO POLIFOSFONATO.
Patent ES-2068692-T3 (ES)
Inventor: COM-NOUGUE JACQUES
IPC: B23K26/34
Filed: 1992-11-19
Granted: 1995-04-16
Abstract: Method for the weld-overlaying of cylindrical workpieces (11) using a laser (13), in which, after facing the surface to be overlayed, the workpiece (11) is rotated about its axis, a laser beam (14) is emitted and partially focused onto the surface of the workpiece (11), and a pre-alloyed powder, having the composition of the alloy to be deposited, is sprayed in the interaction zone (15) between the beam (14) and the workpiece (11). Passes along non-touching generatrices of the rod are carried out, in passes along non-touching helices until the surface of the workpiece (11) is completely covered. Reconstitution of worn surface without appreciable distortion of the workpiece, in particular for steam-turbine control rods. <IMAGE>
Patent ES-2068019-T3 (ES)
Title: Aparato para proteccion de compresores en un sistema de recuperacion de refrigerante.
Inventor: PAIGE LOWELL E
IPC: F25B45/00
Filed: 1992-06-10
Granted: 1995-04-01
Abstract: UN METODO Y APARATO PARA LA RECUPERACION DEL REFRIGERANTE COMPRIMIBLE DE UN SISTEMA DE REFRIGERACION (12) Y EL SUMINISTRO DEL REFRIGERANTE RECUPERADO A UN ELEMENTO DE ALMACENAMIENTO DEL REFRIGERANTE (86). EL METODO DE RECUPERACION CONSISTE EN LOS PASOS DE RETIRAR EL REFRIGERANTE (DE UN SISTEMA DE RECUPERACION (12) EN SERVICIO), COMPRIMIENDOLO, CONDENSANDOLO Y SUMINISTRANDOLO A LOS ELEMENTOS DE ALMACENAMIENTO DEL REFRIGERANTE (86). EN EL MODO DE PRERREFRIGERACION, EL SISTEMA EMPIEZA A RETIRAR EL REFRIGERANTE ALMACENADO DEL ELEMENTO DE ALMACENAMIENTO (86). EL REFRIGERANTE RETIRADO DEL CONTENEDOR DE ALMACENAMIENTO (86) SE COMPRIME, CONDENSA PARA FORMAR UN REFRIGERANTE LIQUIDO QUE SE VUELVE A SUMINISTRAR DIRECTAMENTE AL ELEMENTO DE ALMACENAMIENTO (86) PARA ASI PRERREFRIGERAR EL ELEMENTO DE ALMACENAMIENTO (86) Y EL REFRIGERANTE QUE SE ENCUENTRA DENTRO DE EL. ESTE CICLO DE PRERREFRIGERACION SE LLEVA A CABO DURANTE UN PERIODO DE TIEMPO PREDETERMINADO. TRAS EL PERIODO DE TIEMPO PREDETERMINADO, SE HACE PASAR AL REFRIGERANTE CONDENSADO RETIRADO DEL ELEMENTO DE ALMACENAMIENTO (86) A TRAVES DE UN MEDIO DE EXPANSION ANTES DE VOLVERLO A SUMINISTRAR EL ELEMENTO DE ALMACENAMIENTO (86).
Patent ES-2179820-T3 (ES)
Inventor: EBERT CHARLES D
IPC: A61M37/00
Filed: 1991-12-11
Granted: 2003-02-01
Abstract: Testosterone is administered transdermally through nonscrotal skin in a manner that mimics in amount and profile the natural production of testosterone in young adult healthy males. The testosterone is administered to the skin from a matrix which contains testosterone at subsaturation concentration and a permeation enhancer.
Patent ES-2112922-T3 (ES)
Inventor: VORBRUGGEN HELMUT
IPC: C07H19/20
Filed: 1992-11-23
Granted: 1998-04-16
Abstract: This invention relates to a process for the production of 2-fluoropurine derivatives from 2-aminopurine derivatives, which are reacted in HF/pyridine or HF/pyridine/H2O in the presence of a nitrite.
Patent ES-2151889-T3 (ES)
Inventor: NOSER FRANCIS GERARD
IPC: H04J3/16
Filed: 1993-02-26
Granted: 2001-01-16
Abstract: In a SONET cross connect, the same physical link is used between the interfaces and the matrix to carry the overhead and the payload. The cross connection function within the matrix may be used to group, concentrate and route the overhead signals between a server and the matrix. The matrix may also be used to transport signals between servers. Overhead may be grouped and transported as payload. <IMAGE>   <IMAGE> <IMAGE>
Patent ES-2093297-T3 (ES)
Title: Polimeros, que contienen sulfogrupos.
Inventor: SCHULER BERNHARD DR
IPC: C09K23/00
Filed: 1993-03-09
Granted: 1996-12-16
Abstract: LA INVENCION CONCIERNE A COPOLIMEROS QUE CONTIENEN A) 20 A 90 % DE ACIDO 2 FOETILACRILATO O SULFOPROPIL(MET)ACRILATO, O ACIDO VINILSULFONICO, B) 0 A 50 % DE UN ACIDO VINILICO INSATURADO, C) 0 A 70 % DE METIL LQUILACRILATO O N O C4 COPOLIMEROS DE LA INVENCION SON ESPECIALMENTE ADECUADOS COMO COLOIDES PROTECTORES EN EL MICROENCAPSULADO.
Patent ES-2095517-T3 (ES)
Title: Metodo para la fabricacion de cristales individuales grandes.
Inventor: VICHR MIROSLAV
IPC: C30B25/18
Filed: 1993-06-07
Granted: 1997-02-16
Abstract: SE DESCRIBE UN METODO PARA PRODUCIR GRANDES CRISTALES INDIVIDUALES.SE PRODUCE UN CRISTAL INDIVIDUAL DE DIAMANTE DE GRADO ELECTRONICO CON UN GROSOR DE 100-1000 MICRONES Y UN AREA SUSTANCIALMENTE MAYOR DE 1 CM2 Y QUE TIENE UNA ALTA PERFECCION CRISTALINA, QUE PUEDE SER UTILIZADO EN APLICACIONES MECANICAS OPTICAS ,ELECTRONICAS U OTRAS.UNA LAMINA DE DIAMANTE CRISTALINO SE DEPOSITA PRIMERO SOBRE UN CRISTAL PRINCIPAL EN GRANO Y LAS LAMINAS DE DIAMANTE RESULTANTES SE PUEDEN SEPARAR DEL CRISTAL EN GRANO POR MEDIOS FISICOS MECANICOS Y QUIMICOS.EL CRISTAL PRINCIPAL PUEDE RESTAURARSE POR CRECIMIENTO EPITAXIAL CON SU USO REPETIDO COMO CRISTAL EN GRANO EN POSTERIORES OPERACIONES.SE PUEDE LOGRAR UN GRAN CRISTAL PRINCIPAL DE DIAMANTE EN GRANO AL COMBINAR LOS PEQUEÑOS CRISTALES EN GRANO ORIENTADOS POR FUSION EPITAXIAL LATERAL.DESDE AQUI NO HAY LIMITE DE VECES EN QUE SE PUEDEN REPETIR LOS PASOS DE COMBINACION DEL CRISTAL.SE PUEDEN FABRICAR GRANDES SECTORES DE DIAMANTE COMPARABLES EN TAMAÑO A LOS DE SILICONA.
Patent ES-2131090-T3 (ES)
Inventor: BONIGK MICHAEL
IPC: H05B41/392
Filed: 1993-12-22
Granted: 1999-07-16
Abstract: In the method and the circuit arrangement for setting different colour temperatures in a pulse-driven high-pressure sodium discharge lamp, the colour temperature is shifted without any substantial change in the flux and the colour rendition index by changing the instantaneous pulse power which is supplied to the lamp. It is advantageous for the instantaneous power pulses to consist, during pulsed operation, of a radio-frequency oscillation having a specific basic frequency (fundamental frequency), and the instantaneous pulse power is changed by changing the basic frequency. <IMAGE>
Patent ES-2101226-T3 (ES)
Inventor: MALLY TIMOTHY G
IPC: G01M3/36
Filed: 1993-03-19
Granted: 1997-07-01
Abstract: An apparatus and a method are provided for detecting leaks in sealed packages (26). The apparatus and method are particularly well-suited for an on-line system wherein each package (26) filled and sealed on a commercial packaging line (21) is inspected for possible leaks or seal defects. A force transducer arrangement (51,52,53,54;62,63) is used, and the package (26) is maintained at substantially constant volume while positive wall pressure over time is monitored. Diagnostic properties can be included whereby it is possible to precisely detect exactly which compartment of a multiple-compartment package and exactly which package station, has an excessive incidence of defects. <IMAGE>
Patent ES-2094481-T3 (ES)
Title: Agente preventivo de las incrustaciones de polimeros.
Inventor: SHIMIZU TOSHIHIDE
IPC: C07C251/22
Filed: 1993-06-04
Granted: 1997-01-16
Abstract: UN AGENTE PREVENTIVO CONTRA ESCAMAS POLIMERAS PARA USAR EN POLIMERIZACION DE UN MONOMERO QUE TIENE UN DOBLE ENLACE NO SATURADO ETILENICAMENTE, CONTENIENDO UN PRODUCTO DE CONDENSACION OBTENIDO POR CONDENSACION DE (A) UN COMPUESTO DE DIAMINA ALIFATICA, Y (B) UN COMPUESTO DE QUINONA, EN UN MEDIO ACUOSO. DONDE EL MONOMERO SE POLIMERIZA EN UNA VASIJA DE POLIMERIZACION QUE TIENE SOBRE LA SUPERFICIE DE SUS PAREDES INTERNAS UNA CUBIERTA CONTENIENDO EL AGENTE PREVENTIVO. LA DEPOSICION DE ESCAMAS DEL POLIMERO SE PUEDE PREVENIR EFECTIVAMENTE, NO SOLO EN LA PORCION DE LA FASE LIQUIDA EN LA VASIJA DE POLIMERIZACION, SINO TAMBIEN EN LA PROXIMIDAD DE LA ENTREFASE DE LA PORCION DE FASE GASEOSA Y DE LA PORCION DE FASE LIQUIDA, DE MODO QUE EL POLIMERO ASI OBTENIDO PROVEE UN ARTICULO MOLDEADO CON POCOS OJOS DE PEZ Y REDUCIDA COLORACION INICIAL, CUANDO EL POLIMERO SE MOLDEA EN LAMINAS O FORMAS SIMILARES.
Patent ES-2233926-T3 (ES)
Title: Remodelado de la superficie de anticuerpos de roedores.
Inventor: PEDERSEN JAN T
IPC: A61K39/395
Filed: 1993-09-07
Granted: 2005-06-16
Abstract: SE DESCRIBE UN METODO PARA DETERMINAR LA HUMANIZACION DE ANTICUERPOS DE ROEDORES O FRAGMENTOS DE ELLOS MEDIANTE SU RECUPERACION, Y COMPRENDE: (A) DETERMINAR LA ESTRUCTURA CONFORMACIONAL DE LA REGION VARIABLE DEL ANTICUERPO O SU FRAGMENTO CONSTRUYENDO UN MODELO TRIDIMENSIONAL DE DICHA REGION; (B) GENERAR LINEAS SECUENCIALES DE DISTRIBUCIONES RELATIVAMENTE ACCESIBLES A PARTIR DE ESTRUCTURAS CRISTALOGRAFICAS DE RAYOS-X DE UN NUMERO SUFICIENTE DE CADENAS LIGERAS Y PESADAS DE LA REGION VARIABLE PARA PROPORCIONAR UN GRUPO DE POSICIONES DEL ARMAZON DE CADENAS LIGERAS Y PESADAS EN EL QUE DICHO GRUPO ES IDENTICO EN UN 98% A DICHO NUMERO DE CADENAS DEL ANTICUERPO; (C) DEFINIR PARA DICHO ANTICUERPO O FRAGMENTO, UN GRUPO DE RESIDUOS DE AMINOACIDOS EXPUESTOS A UNAS SUPERFICIES DE CADENAS LIGERAS Y PESADAS UTILIZANDO LAS POSICIONES GENERADAS EN EL PASO (B); (D) IDENTIFICAR A PARTIR DE LAS SECUENCIAS DE AMINOACIDOS DE ANTICUERPOS CORPORALES, UN GRUPO DE RESIDUOS DE AMINOACIDOS EXPUESTOS A UNAS SUPERFICIESDE CADENA QUE ES CASI IDENTICO AL GRUPO DE RESIDUOS DEFINIDOS EN EL PASO (C), EN EL QUE LAS CADENAS LIGERAS Y PESADAS DEL ANTICUERPO HUMANO ESTAN O NO PAREADAS NATURALMENTE; (E) SUSTITUIR EN LA SECUENCIA DE AMINOACIDOS DEL ANTICUERPO DE ROEDOR O FRAGMENTO QUE DEBE HUMANIZARSE, DICHO GRUPO DE RESIDUOS DE AMINOACIDOS DEFINIDOS EN EL PASO (C), CON EL GRUPO DE RESIDUOS AMINOACIDOS IDENTIFICADOS EN EL PASO (D); (F) CONSTRUIR UN MODELO TRIDIMENSIONAL DE LA REGION VARIABLE RESULTANTE DE LA SUSTITUCION ESPECIFICA DEL PASO (E); (G) IDENTIFICAR, COMPARANDO LOS MODELOS TRIDIMENSIONALES CONSTRUIDOS EN LOS PASOS (A) Y (F), CUALQUIER RESIDUO DE AMINOACIDO DEL GRUPO IDENTIFICADO EN EL PASO (D), QUE ESTA ENTRE 5 ANGSTROMS DE CUALQUIER ATOMO DE RESIDUO DE LAS REGIONES DETERMINADAS COMPLEMENTARIAS DEL ANTICUERPO; Y (H) CAMBIAR CUALQUIER RESIDUO IDENTIFICADO EN EL PASO (G) DEL HUMANO AL RESIDUO AMINOACIDO ORIGINAL DEL ROEDOR PARA DEFINIR UN GRUPO HUMANIZADO DE ANTICUERPOS DE ROEDORES DE LOS RESIDUOS AMINOACIDOS EXPUESTOS A LA SUPERFICIE; CON LA CONDICION DE QUE EL PASO (A) NO NECESITA SER EL PRIMERO, PERO SI HA DE REALIZARSE ANTES QUE EL (G).
Patent ES-2098698-T3 (ES)
Inventor: PERRIER RENE
IPC: B67C3/20
Filed: 1993-10-06
Granted: 1997-05-01
Abstract: The invention relates to a measurer for successively and rhythmically drawing off measured quantities of liquid from a reservoir (7), comprising a measurer body (26) intended to be mounted in a fixed manner with respect to the reservoir (7), characterised in that it comprises a drawing-off plunger (31) and means (32) of transmission of movement to drive this plunger (31) with an alternating motion in the liquid, resulting in the measuring of the liquid in one direction and in the pumping of the liquid in the other direction. The invention also relates to a measuring valve (8) comprising such a measurer and a measuring device comprising such a measuring valve. <IMAGE>