Patent SG-11201811093R-A (SG)
Title: Antimicrobial compounds and methods for use thereof
Inventor: KAO YI TSUN
IPC: A61P31/04
Filed: 2017-06-12
Abstract: NO () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 December 2017 (21.12.2017) WIPO I PCT (51) International Patent Classification: A61K 31/426 (2006.01) C07D 263/18 (2006.01) A61K 31/421 (2006.01) A61P 31/04 (2006.01) CO7D 277/36 (2006.01) (21) International Application Number: PCT/CN2017/087898 (22) International Filing Date: 12 June 2017 (12.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/349,823 14 June 2016 (14.06.2016) US (71) Applicant: THE UNIVERSITY OF HONG KONG [CN/CN]; Pokfulam Road, Hong Kong (CN). (72) Inventors: KAO, Yi Tsun, Richard; Flat E, 7th Floor, Tower 1, The Sparkle, 500 Tung Chau Street, Cheung Sha Wan, Kowloon, Hong Kong (CN). YAM, Hin Cheung, Bill; Flat LD, 20th Floor, Tower 5 (Oslo), The Capitol, LO- HAS Park, Tseung Kwan 0, New Territories, Hong Kong (CN). GAO, Peng; Flat D, 10th Floor, Block 42, Cityone, Shatin, Hong Kong (CN). IU, Ho Ting; Flat A, 33rd Floor, Block 7, Jubilee Garden, Fo Tan, New Territories, Hong Kong (CN). (74) Agent: CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center, 23 Harbour Road, Wanchai, Hong Kong (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: ANTIMICROBIAL COMPOUNDS AND METHODS FOR USE THEREOF (57) : Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The com- pounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have antivir- ulence properties. Pharmaceutical compositions including the compounds and a pharmaceutically acceptable carrier are provided. The pharmaceutical composition can further include at least one antibiotic, such as, Gentamicin, amikacin, kanamycin, neomycin, spectin- omycin, neamine or any combination thereof. The compounds and compositions can be used to treat or prevent microbial infections. oimitia inn Holonumlionflo oimIE (10) International Publication Number WO 2017/215552 Al