baber/WOPTO huggingface dataset:
Patent WO-2021173379-A1 (WO)
Inventor: HALL PHILIP S
IPC: F02M37/28
Filed: 2021-02-16
Abstract: A water drain valve system structured to drain water from a fuel-water separator. The system includes a collection vessel structured to temporarily store water, a liquid level sensor structured to monitor a level of the temporarily stored water, a drainage port extending radially from the collection vessel and having a port inlet and a port outlet, and a valve assembly. The port inlet receives water to be drained from the collection vessel, the water flowing through the drainage port and exiting through the port outlet. The valve assembly is movable between a closed position in which the port outlet is closed, and an open position, in which the port outlet is open, to selectively allow water to be drained from the collection vessel. The valve assembly includes a solenoid coupled to a seal member, the seal member closing the port outlet in the closed position of the valve assembly.
Patent WO-2021173612-A1 (WO)
Inventor: ZHANG YANLIANG
IPC: C07K16/46
Filed: 2021-02-24
Abstract: The present disclosure provides activatable masked antigen binding proteins comprising an antigen binding protein attached to universal masking moieties by peptide linkers. The universal masking moieties dimerize with each other to form a dimerized masking complex that blocks binding between the antigen binding domain and its target antigen. The individual masking moieties and the dimerized masking complex do not bind specifically to the antigen binding domain. The masking moieties form stable dimers because their association with each other mimics homodimers or heterodimers found in naturally-occurring immunoglobulin or cell receptor molecules. The dimerization of the masking moieties does not involve covalent bonding and can be optimized by engineering interchain association through structure complementarity such as knob-in-hole.
Patent WO-2021173771-A1 (WO)
Title: Film d'article d'emballage à contenu récupéré
Inventor: RIVETT JANET
IPC: B32B27/08
Filed: 2021-02-25
Abstract: L'invention concerne un film multicouche, un article d'emballage et un procédé de fabrication d'un article d'emballage à partir du film multicouche. Le film multicouche ayant une teneur en déchets d'au moins 25 % , un agent de compatibilité et un antioxydant et étant utile pour l'emballage de produits alimentaires. Les déchets comprennent un mélange de polymères récupérés à partir de flux de déchets et du recyclage.
Patent WO-2021183530-A1 (WO)
Title: Self-stratifying coatings
Inventor: VIRTANEN JORMA
IPC: C09D201/00
Filed: 2021-03-09
Abstract: A self-stratifying anticorrosive coating is described herein, including a zinc-rich epoxy, a curing agent chosen from the group consisting of amines, thiols, phenols, and carboxylic anhydrides, a binding agent chosen from the group consisting of aminoalkyl dialkoxysilane, dimethoxysilane, and aminoalkyl trialkoxysilane, a graphitic material, a solvent, and a water scavenge.
Patent WO-2021188539-A1 (WO)
Title: Testing situational awareness of drivers tasked with monitoring a vehicle operating in an autonomous driving mode
Inventor: HUTCHINGS KEITH
IPC: B60W50/00
Filed: 2021-03-16
Abstract: Aspects of the disclosure relate to testing situational awareness of a test driver tasked with monitoring the driving of a vehicle 100 operating in an autonomous driving mode. For instance, a signal that indicates that the test driver may be distracted may be identified. Based on the signal, that a question can be asked of the test driver may be determined. A plurality of factors relating to a driving context for the vehicle may be identified. Based on the determination, a question may be generated based on the plurality of factors. The question may be provided to the test driver. Input may be received from the test driver providing an answer to the question.
Patent WO-2021202107-A1 (WO)
Title: Shareable composites and methods of preparation thereof
Inventor: LAKROUT HAMED
IPC: C08J9/00
Filed: 2021-03-18
Abstract: Shapeable composites and methods of use and manufacturing are described herein. The shapeable composites may include a polymer and a functional filler, e.g., the functional filler present in an amount greater than or equal to 40% by weight, based on the total weight of the shapeable composite. The shapeable composite may be a foam composite having a viscoelasticity, such that the shapeable composite is configured to be reshaped.
Patent WO-2021202826-A1 (WO)
Title: Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy
Inventor: QI XIAOYANG
IPC: A61K9/127
Filed: 2021-04-01
Abstract: Many tumors induce and maintain an immunosuppressive tumor microenvironment (TME) that enables tumor to escape host immune system. The present disclosure identifies that cancer cells secrete exosome/microparticle-free, soluble, phosphorylated Hsp70 (pHsp70 (Heat Shock Protein 70 (Hsp70))), which triggers macrophage (M) M2 polarization. It is a further aspect that lipid nanovesicles (NVs) made of dioleoylphosphatidylglycerol (DOPG) and of DOPG complexed with saposin C (SapC) bind to cancer secreted Hsp70, inhibit M differentiation and polarization, and reduce tumor growth. In addition, administration of DOPG-NVs rendered monocytes insensitive to TLR2 (Toll Like Receptor 2) and TLR6 (Toll Like Receptor 6) ligands, suggesting that administration of DOPG-NVs interferes with TLR function.
Patent WO-2021211926-A1 (WO)
Title: Methods for controlling meristem size for crop improvement
Inventor: O'CONNOR DEVIN
IPC: A01H5/10
Filed: 2021-04-16
Abstract: This invention relates to compositions and methods for modifying  CLAVATA3/EMBRYO SURROUNDING REGION-RELATED  ( CLV3/ESR-RELATED )   ( CLE )   genes in   plants to increase increased kernel row number, optionally without substantially decreasing the length of the ears. The invention further relates to plants having increased kernel row number, optionally without substantially decreasing the length of the ears, produced using the methods and compositions of the invention.
Patent WO-2021216901-A1 (WO)
Inventor: LEI JING
IPC: H04W72/04
Filed: 2021-04-22
Abstract: Wireless devices are configured to facilitate UE assisted bandwidth part (BWP) selection in wireless communication systems. According to one example, a scheduled entity can receive an RRC reconfiguration message indicating a handover from a source cell to a target cell, identify uplink data in the buffer, and send an enhanced UE assistance information (UAI) transmission to the target cell, the enhanced UAI indicating a preferred BWP of the target cell. In addition, a scheduling entity can receive an enhanced UAI transmission from a scheduled entity indicating a preferred BWP for the scheduled entity, and select the preferred BWP for communication with the scheduled entity from the enhanced UAI. Other aspects, examples, and features are also included.
Patent WO-2021216994-A1 (WO)
Inventor: VELASQUEZ MIREYA PAULINA
IPC: A61K35/17
Filed: 2021-04-23
Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an extracellular target-binding domain comprising at least one glucose-regulated-protein 78 (GRP78)-binding moiety. The present invention further provides polynucleotides and recombinant vectors encoding such CARs. The present invention further provides isolated host cells and methods for preparing isolated host cells expressing the CARs. The present invention further provides pharmaceutical compositions comprising the host cells and methods for treating a tumor using the pharmaceutical compositions.
Patent WO-2021231076-A1 (WO)
Title: Efficient memory bus management
Inventor: SHEN GUANHAO
IPC: G06F3/06
Filed: 2021-04-27
Abstract: A memory controller an arbiter which causes streaks of read commands and streaks of write commands over the memory channel. During a streak, the arbiter monitors an indicator of data bus efficiency of the memory channel. Responsive to the indicator showing that data bus efficiency is less than a designated threshold, the arbiter stops the current streak and start a streak of the other type.
Patent WO-2021222376-A1 (WO)
Inventor: LUNDY ERIC S
IPC: B60R1/04
Filed: 2021-04-28
Abstract: A rearview assembly is disclosed. The rearview assembly comprises a reflective element and/or a display element. Further, the rearview assembly comprises an array of piezo-electric sensors. The array of piezo-electric sensors may be operable to sense a first vibration. Further, based, at least in part, on sensing the first vibration, the array of piezo-electric sensors may be operable to output a second vibration. In some embodiments, the second vibration may be operable to substantially dampen the first vibration. In other embodiments, the second vibration may be operable to provide haptic feedback to a user interfacing with a touch screen surface of the rearview assembly.
Patent WO-2021222900-A1 (WO)
Inventor: VASS BRADLEY
IPC: E21B43/119
Filed: 2021-05-03
Abstract: An apparatus for perforating a subterranean formation comprises a first perforating gun (33b) having a box end (112) having a nose, a second perforating gun (33a) having a pin end (118) having a shoulder (124); and an alignment assembly. The alignment assembly includes internal threads formed on the box end, external threads formed on the pin end, and an alignment member (120) positioned between the box end nose and the pin end shoulder. The internal threads and the external threads are specified to form an angular alignment between the first perforating gun and the second perforating gun within a first specified angular tolerance. The alignment member has at least one characteristic selected to vary the angular alignment within the first specified angular tolerance without degrading a locking force connecting the first perforating gun to the second perforating gun.
Patent WO-2021225969-A1 (WO)
Title: Imino sulfanone inhibitors of enpp1
Inventor: COGAN DEREK A
IPC: A61P35/00
Filed: 2021-05-03
Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to sulfoximine- based inhibitors of ENPP1 of Formula (I) and methods of their use for treating disease mediated by ENPP1.
Patent WO-2021231258-A1 (WO)
Inventor: KOLLER KEVIN DAVID
IPC: B64F1/08
Filed: 2021-05-10
Abstract: L'invention concerne des caractéristiques pour la récupération en vol d'un véhicule aérien sans pilote (UAV). Un câble de remorque (165) peut être déployé par un aéronef hôte (150) en vol afin de récupérer un UAV cible (180) qui est également en vol. Une bobine (162) sur l'aéronef hôte peut dévider le câble de remorque équipé d'un raccord (172). Un cliquet (182) sur l'UAV cible peut venir en prise avec le raccord sur le câble de remorque, et la bobine peut ensuite rétracter le câble de remorque pour ainsi tirer l'UAV cible vers l'aéronef hôte. L'UAV cible peut ensuite se fixer solidement à l'aéronef hôte.
Patent WO-2021231978-A1 (WO)
Title: Method and system for predicting cellular aging
Inventor: JOHANNESSON BJARKI
IPC: G01N33/00
Filed: 2021-05-14
Abstract: The present disclosure provides automated methods and systems for implementing an aging analysis pipeline involving the training and deployment of a predictive model for predicting cellular ages of cells. Such a predictive model distinguishes between morphological cellular phenotypes e.g., morphological cellular phenotypes elucidated using Cell Paint, exhibited by cells of different ages. The predictive model is further useful for developing new cellular aging assays that include biomarkers that heavily contribute towards predictions of the predictive model. Furthermore, the predictive model is useful for screening drug candidates for their ability to alter or suppress age related phenotypes.
Patent WO-2021247262-A1 (WO)
Inventor: ZHAO XUANHE
IPC: A61K33/24
Filed: 2021-05-24
Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.
Patent WO-2021247306-A1 (WO)
Inventor: PALMER LARRY THOMAS
IPC: E21B23/04
Filed: 2021-05-26
Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve arranged in the flowbore. The backpressure valve includes a flapper valve having a first side and an opposing second side pivotally mounted to the inner surface to selectively extend across the flowbore and a locking system mounted to the inner surface in the flowbore and snapfittingly engageable with the flapper valve. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface, and a second position, wherein the flapper valve is pivoted away from the flowbore and locked open by the locking system such that the first side forms part of the flowbore.
Patent WO-2021247477-A1 (WO)
Inventor: O'CONNOR DEVIN
IPC: A01H6/46
Filed: 2021-06-01
Abstract: This invention relates to compositions and methods for modifying CORYNE (CRN) genes inplants to optionally increase kernel row number and/or improve one or more yield traits. The invention further relates to plants having increased kernel row number and/or one or more improved yield traits produced using the methods and compositions of the invention.
Patent WO-2021252459-A1 (WO)
Inventor: SAVAGE PAUL B
IPC: A61P31/12
Filed: 2021-06-08
Abstract: La présente invention concerne des compositions et des procédés de désactivation de coronavirus. Un procédé comprend l'obtention d'une composition de désactivation comprenant un ou plusieurs composés CSA et un support, et l'administration de la composition de désactivation à un sujet, cette composition de désactivation désactivant des virions de coronavirus dans le sujet ou venant en contact avec le sujet. Le procédé peut ainsi empêcher, diminuer ou inhiber une infection à coronavirus, telle que la COVID-19, chez le sujet.
Patent WO-2021257606-A1 (WO)
Title: Carbon disulfide-modified amine additives for separation of oil from water
Inventor: ZOU JIAN
IPC: C02F1/54
Filed: 2021-06-15
Abstract: A carbon disulfide-modified amine additive may be introduced to an aqueous stream in an effective amount to separate oil from the water in the aqueous stream, such as separating at least some of the oil from emulsified oil-in-water in a production fluid, where the oil is crude oil. The carbon disulfide-modified amine additive may be produced from a reaction of synthetic amine, natural amines, or chemically modified natural amines with carbon disulfide and an α,β- unsaturated compound and/or an epoxide in one step. In one non-limiting embodiment, the amine is a natural amine or chemically modified natural amine of a polysaccharide containing amino functional group(s). Optionally, a base catalyst is used to make the carbon disulfide-modified amine additive.
Patent WO-2022271155-A1 (WO)
Inventor: PRABHU RAJASEKARA
IPC: A61M1/00
Filed: 2021-06-22
Abstract: A drainage system for draining bodily fluid from a body cavity includes a fluid-receiving body having a fluid-receiving chamber located therein that receives a bodily fluid through an inlet. An actuation body is connected to the fluid-receiving body. The actuation body includes an actuation member that is accessible from outside the actuation body and is manually movable relative to the actuation body along a dimension of the actuation body. The actuation member is operatively connected to a suction inducing member. Manual actuation of the actuation member relative to the actuation body moves the suction inducing member thereby increasing a volume of a suction chamber and reducing a pressure within the suction chamber. The reduced pressure communicated through the inlet of the fluid-receiving body.
Patent WO-2021262802-A1 (WO)
Title: Système de réticulation réversible pour polyvinylamines
Inventor: TAUBERT FLORIAN
IPC: B05D3/10
Filed: 2021-06-23
Abstract: Un polymère contenant une vinylamine comprend des unités monomères répétées réparties de manière aléatoire ayant au moins deux des formules suivantes : (I); (II); (III); et (IV), R1 représentant un atome d'hydrogène ou un groupe méthyle; et le polymère contenant une vinylamine comprenant une unité monomère répétée III et/ou IV dans une quantité totale d'environ 1,5 pour cent en poids à environ 8 pour cent en poids sur la base d'un poids total du polymère.
Patent WO-2022005875-A1 (WO)
Inventor: MCGRATH MICHAEL S
IPC: A61P25/28
Filed: 2021-06-24
Abstract: L'invention concerne des méthodes de traitement d'un sujet ayant, ou à risque de développer, un syndrome de détresse respiratoire aiguë (SDRA) par l'administration d'une composition de chlorite en une quantité efficace pour traiter le sujet. Des aspects des méthodes comprennent également l'administration d'une formulation de chlorite à un sujet ayant ou suspecté d'avoir une infection à coronavirus, par exemple, le coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2), le syndrome respiratoire aigu sévère (SRAS-CoV), ou l'infection par le coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV). L'invention concerne également des méthodes de régulation de l'activité des macrophages chez un sujet ayant, ou à risque de développer un SDRA par la mise en contact d'un macrophage d'un sujet ayant ou risquant de développer un SDRA avec une composition de chlorite en une quantité efficace pour réguler une ou plusieurs propriétés fonctionnelles du macrophage. L'invention concerne également des méthodes de détermination de l'inhibition d'une activité de macrophage induite par un SDRA par un agent chlorite.
Patent WO-2022010902-A1 (WO)
Title: Refrigeration system leak detection
Inventor: WELCH ANDREW M
IPC: F24F11/36
Filed: 2021-07-06
Abstract: A refrigeration system includes: a leak sensor disposed within a building and configured to measure an amount of refrigerant that has leaked from the refrigeration system within the building; a prediction module configured to determine a predicted amount of refrigerant that has leaked from the refrigeration system within the building based on the measured amount; and a leak module configured to: determine whether a leak is present in the refrigeration system within the building based on the predicted amount of refrigerant that has leaked from the refrigeration system; and take one or more remedial actions when a leak is present in the refrigeration system within the building.
Patent WO-2022015969-A1 (WO)
Inventor: BOWEN TYSON D
IPC: C07K14/31
Filed: 2021-07-15
Abstract: Compositions et procédés comprenant des polypeptides stabilisant l'uracile pour l'édition ciblée d'acides nucléiques. Les compositions comprennent des polypeptides stabilisant l'uracile. L'invention concerne également des protéines de fusion comprenant i) un polypeptide de liaison à l'ADN ; Ii) une désaminase ; et iii) un polypeptide stabilisant l'uracile (USP). Les protéines de fusion comprennent des nucléases guidées par ARN fusionnées à des désaminases et fusionnées en outre à un USP, éventuellement en complexe avec des ARN guides. Les compositions comprennent également des molécules d'acide nucléique codant pour les USP ou les protéines de fusion. L'invention concerne également des vecteurs et des cellules hôtes comprenant les molécules d'acide nucléique codant pour les USP ou les protéines de fusion.
Patent WO-2022016149-A1 (WO)
Inventor: SKOMRA STEWART
IPC: G08B1/08
Filed: 2021-07-19
Abstract: L'invention concerne un système d'exploitation de transport universel (UniTOS) avec une logique de meilleur déplacement suivant qui permet l'application d'algorithmes de commutation de paquets et de défragmentation pour déterminer le temps et l'emplacement optimaux pour la distribution et/ou la réception de charges utiles tant immatérielles que matérielles.
Patent WO-2022026315-A1 (WO)
Inventor: GHOSH SUBHAM
IPC: A61N1/05
Filed: 2021-07-23
Abstract: The present disclosure relates generally to pacing of the cardiac conduction system of a patient, and more particularly, to providing adaptive cardiac conducting system pacing therapy and to determining selective or non-selective capture of the cardiac conduction system by cardiac conduction system pacing therapy. The adaptive cardiac conduction system pacing therapy may adjust AV delay and VV delay based on various signals and metrics and may switch between cardiac conduction system pacing therapy exclusively and cardiac conduction system pacing therapy in combination with traditional left ventricular pacing therapy.
Patent WO-2022026671-A1 (WO)
Inventor: BACKHAUS-RICOULT MONIKA
IPC: C04B35/636
Filed: 2021-07-29
Abstract: A ceramic powder, batch mixture including the ceramic powder, green article shaped from the batch mixture, method of manufacturing a ceramic powder, and method of manufacturing a ceramic article. The ceramic powder comprises a plurality of porous ceramic beads. The ceramic beads have a median particle size of at least 20 µm, a median pore size of less than 4 µm; and an open porosity of at least 12%.
Patent WO-2022060500-A1 (WO)
Title: Modular framing structure design and a method of using the same
Inventor: LIN WEI-JAN
IPC: A47F5/04
Filed: 2021-08-16
Abstract: A modular structure system of detachable members, the system includes a support pillar and various connectors. The support pillar has a main body and a plurality of channel walls outwardly radiating from an outside surface of the main body. The channel walls are disposed lengthwise on the main body from one terminal end of the main body to another terminal end of the main body. The support pillar has a symmetrical cross-sectional shape and each of the channel walls has an expanded distal end forming two lips.
Patent WO-2022040432-A1 (WO)
Title: Vecteurs de type virus adéno-associé pour le traitement du syndrome de rett
Inventor: O'BANION COLIN
IPC: C12N7/00
Filed: 2021-08-19
Abstract: L'invention concerne des acides nucléiques (comprenant des cassettes d'expression d'AAV), des vecteurs d'AAV, et des compositions destinés à être utilisés dans des méthodes de traitement et/ou de retardement de l'apparition de maladies associées à des mutations du gène  mecp2 , telles que le Syndrome de Rett. L'invention concerne également des méthodes de traitement et/ou de retardement de l'apparition de maladies associées au facteur neurotrophique dérivé du cerveau (BDNF).
Patent WO-2022051649-A1 (WO)
Inventor: HOLLISTER SCOTT J
IPC: A61M39/10
Filed: 2021-09-03
Abstract: Systems, methods, and devices for prohibiting contaminants from entering a central venous catheter connection are disclosed. A device described herein includes a first body section defining a first internal cavity and a second body section defining a second internal cavity. The second body section can be hingeably connected to the first body section. A first tubing notch is positioned at an end of at least one of the first body section or the second body section. The device has an open configuration and a closed configuration, and wherein, in the closed configuration, the first internal cavity and the second internal cavity are adjacent to create a connector cavity configured to contain a first connector.