baber/WOPTO huggingface dataset:
Patent CA-2683585-A1 (CA)
Inventor: GULLIVER WAYNE
IPC: G16B20/50
Filed: 2008-04-14
Abstract: The invention provides methods for predicting responsiveness to a biologic agent in a subject suffering from psoriasis. The methods involve assaying for the presence or absence of an allele or polymorphism in the subject that is predictive of responsiveness to biologic therapy, such as an HLA-Cw6 allele, a TNF.alpha. 238 polymorphism or a TNF.alpha. 308 polymorphism. The methods can further comprise selecting a treatment regimen with a biologic agent in a psoriasis subject based upon presence or absence of the allele or polymorphism in the subject. The methods can further comprise administering a biologic agent to the subject according to the selected treatment regimen. Kits that include means for assaying an allele or polymorphism that is predictive of responsiveness to biologic therapy for psoriasis are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting a psoriasis subject for treatment with a biologic agent are also provided.
Patent CA-2684399-A1 (CA)
Title: An integrated device for the treatment of drill cuttings
Inventor: CHRISTENSEN MATHEUS
IPC: B09B3/00
Filed: 2008-04-15
Abstract: An integrated unit (1) for the treatment of drill cuttings, comprising one or more drill cutting inlets (2), one or more water inlets (4), one or more binder inlets (3) and one or more additive inlets (6). One or more measuring devices are arranged for measuring the composition of the drill cuttings furnished to the unit. One or more dosage units are arranged for furnishing the required amount of binder or additive respectively. The device further comprises a mixing (7) unit arranged for mixing the compounds and a first granulation unit (8) for milling, granulating, setting and hardening the mixture. The invention further describes a method for the treatment of drill cuttings and the use of an integrated unit on an off-shore drilling unit.
Patent CA-2686484-A1 (CA)
Inventor: LI YINGFU
IPC: C07D497/04
Filed: 2008-05-09
Abstract: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Patent CA-2686864-A1 (CA)
Inventor: KIM YOUN SOO
IPC: G06F3/033
Filed: 2008-05-06
Abstract: A mouse device, which causes to move a pointer or cursor of a computer, includes a housing having a receiving part therein, a mouse body fitted inside the receiving part, and a detecting means located on an inside wall of the receiving part. The detecting means detects a movement of the mouse body when pressed by the mouse body, thereby causing the pointer to move. The mouse device of the invention is not required to move beyond a limited range in order to cause the pointer to move, thereby improving the usability thereof. Since the mouse device is not required to move beyond the predetermined range, the use of the mouse device can reduce the fatigue of the wrist of the user, thereby preventing a pain in the wrist.
Patent CA-2690185-A1 (CA)
Inventor: NAGANO TAKUJI
IPC: H01M8/24
Filed: 2008-06-12
Abstract: A fuel cell (100) has a porous body fuel gas passage (24) made of a porous metal (30a) disposed within an anode-side outer frame plate (34), a porous body coolant passage (26) made of a porous metal (30b) within an intermediate outer frame plate (10), and a porous body oxidizer gas passage (22) made of a porous metal (30c) within a cathode-side outer frame plate (32). The porous body fuel gas passage (24) and the porous body coolant passage (26) are separated by a metal film (20), and the porous body oxidizer gas passage (22) and the porous body coolant passage (26) are separated by a metal film (20). The outer sizes of the porous body fuel gas passage (24) and the porous body oxidizer gas passage (22) are smaller than those of the metal films (20).
Patent CA-2691259-A1 (CA)
Inventor: FORBES JAMES W
IPC: B61D7/02
Filed: 2010-01-27
Abstract: Lécoulement dévacuation dun wagon-trémie est contrôlé par des éléments de fermeture, dont au moins un est mobile. Les portes sans charnière sont installées sur quatre liens à barre, de sorte que le rebord distal des portes se déplace horizontalement de manière prédominante alors que le rebord proximal de la porte se déplace verticalement de manière prédominante. Les portes parcourent des arcs non circulaires, de sorte que la dimension de louverture de porte projetée verticalement est anormalement large par rapport aux hauteurs libres de la porte. Les portes sont entraînées par un arbre longitudinal qui est installé à lintérieur de lappui central. Il entraîne un ensemble de renvois dangle à entrée simple, sortie double, qui entraîne les paires adjacentes de portes et qui emploie une bascule excentrée pour tenir les portes en position fermée lorsque le wagon est chargé. Les actionneurs peuvent être installés dans les abris à mi-chemin le long du wagon et peuvent être décalés de lappui central. Les actionneurs peuvent être installés verticalement de manière prédominante de sorte que la gravité peut éviter le recours à un deuxième verrou. Il nest pas nécessaire que les portes dun wagon transversal soient de la même dimension. La bascule excentrée peut comporter un mécanisme de dégagement manuel comportant un pivot à réduction progressive ayant un avantage mécanique.
Patent CA-2692173-A1 (CA)
Inventor: FAULRING FRANK WILLIAM
IPC: A01C11/02
Filed: 2010-02-04
Abstract: A transplanting apparatus which can plant virtually 100% of the seedlings from a nursery tray, while avoid skips when planting which may happen when seeds in a tray row fail to grow into seedlings. This is accomplished by picking up an entire row of seedlings from a tray, transferring the seedlings to a mechanism which eliminates gaps between seedlings, and then discharging the seedlings one at a time to the ground with a desired spacing between the seedlings while having full physical control of the seedlings. A root ball compressor is provided to provide better control of the seedlings as the compressed root balls are less likely to tip over, and the compressed root balls are easier to be grabbed by the pinch disks.
Patent CA-2692861-A1 (CA)
Inventor: PINNER ELHANAN
IPC: C12Q1/68
Filed: 2008-07-10
Abstract: There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ  ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof.
Patent CA-2696203-A1 (CA)
Inventor: VEIT FRANK W
IPC: B07C5/36
Filed: 2001-09-28
Abstract: This invention relates to a positive displacement sorter of the pusher shoe and slat configuration, having a conveying surface and diverter shoes to displace articles laterally on the surface. Such conveyors may include a pair of endless chains in a plurality of slats being propeled by rotary motors; each slat is fitted with a diverter shoe mounted glideable laterally across the slat. The present invention provides a positive displacement sorter assembly, comprising slats defining an endless web, an upper run of said web defining a conveying surface; pusher shoes gliding along at least some of said slats to laterally displace articles on said conveying surface; secondary means for defining a plurality of linear motor secondaries at said slats; primary means for producing thrust in said secondaries and thereby propelling said web; and control means for controlling said primary means.
Patent CA-2696798-A1 (CA)
Inventor: LIU KAIFENG
IPC: B32B7/022
Filed: 2008-07-30
Abstract: The present invention provides a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight. The invention also provides a method of forming a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight.
Patent CA-2700523-A1 (CA)
Title: Mri-guided medical interventional systems and methods
Inventor: PIFERI PETER
IPC: A61B19/00
Filed: 2008-09-24
Abstract: An MRI-guided interventional system for use with a body of patient and an interventional device includes a base and a targeting cannula. The base is configured to be secured to the body of the patient. The targeting cannula has an elongate guide bore extending axially therethrough and an inlet and an outlet at opposed ends of the guide bore. The guide bore defines a trajectory axis extending through the inlet and the outlet and be-ing configured to guide placement of the interventional device. The frame is operable to move the targeting cannula relative to the base to position the trajectory axis to a desired intrabody trajectory to guide placement of the in-terventional device in vivo. The inlet tapers from an outer diameter distal from the guide bore to an inner diameter proximate the guide bore to guide and facilitate insertion of the interventional device into the guide bore.
Patent CA-2701132-A1 (CA)
Title: Apparatus for stereotactic neurosurgery
Inventor: DERRICK HUGO GEORGE
IPC: A61B17/34
Filed: 2008-10-06
Abstract: A skull mount (50;150;170;200;300) is described that is attachable to a hole (60) formed in the skull. The skull mount (50;150;170;200;300) comprises an alignment guide (62;152;172;216;306) defining an alignment axis (22;210;312) along which neurosurgical instruments can be passed. The skull mount, when attached to a hole in a skull, is arranged such that it does not substantially protrude from the outermost surface of the skull and does not extend into the brain parenchyma. Also described is a neurosurgical alignment instrument (30,206) for aligning such a skull mount (50;150;170;200;300) that comprises an elongate shaft (32) and an element (34,36) protruding from the distal end of the elongate shaft (32) for engaging and aligning the alignment guide (62;152;172;216;306) of an associated skull mount (50;150;170;200;300). When the alignment instrument is engaged with a skull mount attached to a hole formed in the skull, the protruding element passes through the alignment guide of the skull mount and into the cortex of the subject's brain.
Patent CA-2701202-A1 (CA)
Inventor: SCHERER STEPHEN W
IPC: C40B30/04
Filed: 2008-10-03
Abstract: Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHDI, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1.
Patent CA-2703824-A1 (CA)
Inventor: BAUMANN KARLHEINZ
IPC: C07D417/12
Filed: 2009-01-05
Abstract: The invention relates to compounds of formula (I) R1 is -C(O)O-lower alkyl, cyano or is hetaryl; hetaryl is a five-or six membered heteraryl group, optionally substituted by R'; R' is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen; R2 is hydrogen, lower alkoxy, lower alkyl, halogen or cyano;  R3 is -(CH2)n-C(O)O-lower alkyl, lower alkyl, lower alkoxy, hydroxy, -O-Si(CH3)2-lower alkyl, -C(O)-N(lower alkyl)2, -O-S(O)2-lower alkyl, C3-7-cycloalkyl, S(O)2-aryl, heterocyclyl, -C(O)-heterocyclyl, or is aryl or hetaryl, which aryl or hetaryl rings are optionally substituted by one or more R'; R4 is hydrogen, lower alkyl, hydroxy or CH2CN;  X is S or -N=C(R5)-; R5 is hydrogen, lower alkyl or hydroxy, is a bond, -O-, -CH2-, -CH2-CH2-, formula (II) or or -N(R)-; R is hydrogen, lower alkyl, C(O)O-lower alkyl, C(O)-lower alkyl, S(O)2-lower alkyl, or benzyl; n is 0 or 1 or to pharmaceutically active acid addition salts. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
Patent CA-2705658-A1 (CA)
Inventor: BOEHLING RALF
IPC: C01C3/02
Filed: 2008-11-10
Abstract: The invention relates to a method for the production of hydrocyanic acid, comprising the provision of gaseous formamide by evaporating liquid formamide in an evaporator (step i)) and the catalytic dehydration of the gaseous formamide (step ii)), and a device for carrying out the method according to the invention, comprising at least one microevaporator and a tubular reactor, and the use of a micro-evaporator for evaporating formamide in a method for the production of hydrocyanic acid from formamide.
Patent CA-2706546-A1 (CA)
Title: Absorptive article
Inventor: KAWAKAMI YUSUKE
IPC: A61F13/53
Filed: 2008-11-06
Abstract: According to an absorptive article (disposable diaper) 10 of the present invention, an absorber (absorptive structure) 12 is provided with a first region 55 disposed on an internal surface sheet 41 side and having a higher content ratio of the superabsorptive polymer than a content ratio of the hydrophilic fiber, a second region 56 disposed on an external surface sheet 42 side and having a lower content ratio of the superabsorptive polymer than the content ratio of the superabsorptive polymer in the first region and a higher content ratio of the hydrophilic fiber than the content ratio of the hydrophilic fiber in the first region, and a space that penetrates from the external surface sheet 42 side of the second region 56 to the first region 55, and that can be entered by the superabsorptive polymer that is swollen by absorbing a body fluid in the first region 55.
Patent CA-2708486-A1 (CA)
Inventor: LEONG KOON-WAH
IPC: G01N27/416
Filed: 2010-06-23
Abstract: An analyte test strip an (e.g., an electrochemical-based analyte test strip for determining glucose in a bodily fluid sample) for use with a test meter includes a first insulating layer and a electrically conductive layer disposed on the first insulating layer. The electrically conductive layer includes at least one electrode portion and at least one electrical contact pad configured for an electrical connector pin of a test meter to travel therealong during insertion of the analyte test strip into the test meter. In addition, the electrical contact pad is in electrical communication with the electrode portion. The analyte test strip also includes at least one motor identification feature (such as stripes of visually transparent material) disposed on the electrical contact pad such that the electrical connector pin of the test meter travels across the meter identification feature during insertion of the analyte test strip into the test meter. The analyte test strip further includes a second insulating layer disposed above the first insulating layer and a patterned spacer layer positioned between the first insulating layer and the electrically conductive layer that defines a sample-receiving chamber therein. The electrical contact pad of the analyte test strip has a predetermined contact electrical characteristic value and the meter identification feature has a predetermined identification feature electrical characteristic value that is dissimilar from the predetermined contact electrical characteristic.
Patent CA-2711996-A1 (CA)
Inventor: GILBERT JAMES A
IPC: A61B18/12
Filed: 2010-08-03
Abstract: An electrosurgical system and method are disclosed. The system includes an electrosurgical generator adapted to supply electrosurgical energy to tissue.  The generator is further adapted to supply an electrosurgical signal at a variable power level.  The generator includes sensor circuitry adapted to sense tissue impedance and/or an electrosurgical signal zero crossing. The generator also includes a controller, which may include a microprocessor, that is adapted to receive a tissue impedance signal and/or a waveform zero crossing signal. The controller is configured to monitor tissue impedance, and in response to a threshold value of impedance being reached, to cause a power level of the electrosurgical energy to transition from a first power level to a second power level. The slew rate of the power transition may be in accordance with a transition function, such as a cosine function. The power transition may additionally or alternatively be performed during, or correlated with, an electrosurgical signal zero crossing. The system also includes an electrosurgical instrument including at least one active electrode adapted to apply electrosurgical energy to tissue for treatment.
Patent CA-2712769-A1 (CA)
Inventor: SCHEFFLER DOMINIK
IPC: E05B47/00
Filed: 2010-08-10
Abstract: An actuator-controlled strike comprising a housing disposable within a doorframe and including a cavity for a spring latch and a dead latch of a mortise-typelockset. A keeper is pivotably mounted within the chamber to engage the spring latch. A pivotably mounted kicker cooperates with the keeper. A pivotably mounted dead latch release is supported by the keeper when the spring latch is within the strike. The keeper is released by the actuator and rotates into a position to ramp the spring latch out of the strike, also allowing the dead latch release to release the dead latch into the cavity, allowing the spring latch to be ramped out of the strike. Pivoting the keeper causes the kicker to urge the spring latch onto an exit ramp on a face of the keeper. The dead latch release can be installed in a plurality of different locations in the housing.
Patent CA-2716295-A1 (CA)
Inventor: CAI ZHIJUN
IPC: H04W36/06
Filed: 2010-09-30
Abstract: A method is provided for handing over a user equipment (UE). The method includes a donor access node with which the UE is in communication via a serving relay node receiving UE. context information. The method further includes the donor access node using the UE context information to identify data packets that belong to the UE, wherein the data packets are forwarded from the serving relay node to a target relay node.
Patent CA-2717848-A1 (CA)
Title: Syringe plunger locking mechanism
Inventor: DUCHON DOUGLAS J
IPC: A61M5/315
Filed: 2001-07-20
Abstract: An injection system having a syringe body having a distal portion and a proximal portion, the syringe body defining a pumping chamber. A syringe plunger is located in the pumping chamber and is adapted for reciprocal motion within the pumping chamber. An actuating shaft is coupled to the syringe plunger and is movable through the syringe body to control movement of the plunger, the actuating shaft has a pivot member disposed at a distal portion thereof. A release actuator is disposed proximal to the syringe body, and 
a distal portion of the pivot member is adapted to project radially outwardly when contacted by the syringe plunger to form a releasable engagement with the syringe plunger when the actuating shaft and the pivot member are in an engagement position, and wherein the distal portion of the pivot member is adapted to release the actuating shaft upon engagement of a proximal portion of the pivot member with the release actuator.
Patent CA-2717869-A1 (CA)
Title: Stable three-phased emulsions
Inventor: PATEL AMIT
IPC: C09K23/54
Filed: 2009-03-06
Abstract: Disclosed is a three-phase emulsion comprising an aqueous-gel outer phase; and a water-in-oil inner phase, wherein the emulsion is stable. The aqueous-gel outer phase can include 10% to 50% by weight of the total weight of the emulsion. This phase can also include 70% to 95% by weight of water based on the total weight of the aqueous-gel outer phase, a gelling agent, and an emulsifier having a hydrophilic-lipophilic balance (HLB) value of 10 to 19. The water-in-oil inner phase can include 50% to 95% by weight based on the total weight of the three-phase emulsion. This phase can also include 50% to 80% by weight of water based on the total weight of the water-in-oil inner phase, 20%  to 50% by weight of oil based on the total weight of the water-in-oil inner phase, and an emulsifier.
Patent CA-2718026-A1 (CA)
Inventor: PERRON JEAN
IPC: F25C5/06
Filed: 2010-10-19
Abstract: There is provided an ice protection sleeve for protecting a structure, such as a rotorblade, against icing. The sleeve comprises a shielding sheet to be mounted and attached to cover at least a part to be protected of the structure, the leading edge of the rotorblade for example; a gap between the sheet and the structure to allow vibration of the sheet; and actuators, such as piezoelectric actuators, coupled to the sheet for transmitting mechanical vibrations to the sheet.
Patent CA-2718769-A1 (CA)
Inventor: BASIR OTMAN A
IPC: B60W50/00
Filed: 2010-10-25
Abstract: A telematic system interfaces with a vehicle diagnostic interface to provide access to vehicle health and performance related information. The telematic system includes a primary gateway connector and various subsystem modules that connect to the primary gateway connector to provide functions in addition to those provided by the primary gateway connector.
Patent CA-2720379-A1 (CA)
Title: Dispositif de distribution de boissons gazeuses et robinet a trois positions
Inventor: BUCHIK SERGEI ALEKSANDROVICH
IPC: B67D1/06
Filed: 2009-03-26
Abstract: L'invention concerne l'industrie alimentaire et notamment des équipements de commerce; elle peut s'utiliser pour la distribution de bière et/ou d'autres boissons gazeuses ou moussantes à partir d'un récipient isobarique dans des bouteilles ou gobelets en plastique dans des kiosques de commerce au détail, des magasins, des bars et des restaurants. L'invention permet de simplifier l'entretien de l'équipement de distribution manuelle de boissons grâce à l'élimination du besoin de désinfecter de la partie du tuyau de distribution après chaque remplissage de récipient, et grâce à un entretien simplifié des robinets qui n'ont pas besoin d'être rincés fréquemment au niveaux des unités et des pièces après la fin de distribution de bière et/ou d'autres boissons. Dans cette invention, on utilise deux variantes de conception d'un robinet à trois positions monté dans le dispositif de distribution de boissons gazeuses et/ou moussantes dans des récipients ouverts.
Patent CA-2722590-A1 (CA)
Inventor: NEUSER EBERHARD
IPC: A61B6/03
Filed: 2010-11-26
Abstract: A computed tomography method for determining a volumetric rep-resentation of a sample (13) comprises using reconstructed volume data (23) of the sample (13) from x-ray projections (21) of the sample (13) taken by an x-ray system (10), comput-ing a set of artificial projections (26) of said sample (13) by a forward projection (25) from said reconstructed volume data (23), and determining, essentially from process data (21, 23) of said reconstruction (22) including said reconstructed volume data (23) and/or said x-ray projections (21), individ-ual confidence measures (28) for single voxels of said volume data based on calculating, for each of said measured x-ray projections, the difference between the contribution of this measured x-ray projection to the voxel under inspection and the contribution from a corresponding artificial projection to the voxel under inspection.
Patent CA-2722829-A1 (CA)
Inventor: TOZZO STEPHANIE
IPC: A01K67/027
Filed: 2009-04-27
Abstract: The present invention provides a method of producing diabetic mice and their use in drug development.