Patent SG-11201901989V-A (SG)
Title: Factor viia glycoforms
Inventor: FELDMAN RICHARD IRA
IPC: C12N9/64
Filed: 2017-09-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 011101011M 01 110 1 01011111110101111101010111B 1111 OEN Organization (10) International Publication Number International Bureau (43) International Publication Date ......0\"\" WO 2018/052827 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: (74) Agent: HANSEN, Christine M. et al.; Buchanan Inger- C07K 14/745 (2006.01) A61K 38/17 (2006.01) soli & Rooney PC, P.O. Box 1404, Alexandria, Virginia C07K 14/435 (2006.01) C12N 9/64 (2006.01) 22313-1404 (US). A61K 38/36 (2006.01) C12N 5/10 (2006.01) A61K 38/48 (2006.01) A61P 7/04 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/050887 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 11 September 2017 (11.09.2017) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (25) Filing Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (30) Priority Data: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/393,930 13 September 2016 (13.09.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: BAYER HEALTHCARE LLC [US/US]; 100 kind of regional protection available): ARIPO (BW, GH, Bayer Boulevard, Whippany, New Jersey 07981 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventor: FELDMAN, Richard Ira; 100 Pomona Avenue, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — El Cerrito, California 94530 (US). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: FACTOR VIIA GLYCOFORMS = — FIG. 3 GLYCAN NADER FORMULA EXRUCTURE EMPLARY ST (GIcNAc)4(Man)3(Gai)2(Po = II (C1cNk)Man)3(Gag(Fuc) = III PcNA46(Mar)3(Fuc) = 1 \ / (GIcNAc)5(1,103(G81)3(PLE) = = = V (GcNA06(GaWan)tuc) = vi (acw 4 (man) 3 (GdxFuo = VI (GcNAc)5(Man)3(Fuc) — AI (GIcNAc)5(Man)3(Gal) 11 I X (Man)5(GIGNA43(G1)(Fuc) Ba IN N X (dcNAc)3(Man)3(GA)(Fuc) LEGEND GC 0 = GALACTOSE (Gal) N 11 in © XI (GNNAck(Man)3(G4I) O a z N- :, — TYLOALACTOSAMINE (GIGNAc) 0 = gANC3E (Mall) 4 =FUCOSE (Fuc) --.... ,-1 (57) : Factor VII glycoproteins having glycosylation patterns that render them suitable for therapeutic indications such as 0 postpartum hemorrhage requiring short half -life and rapid and high clearance are disclosed with related methods of making and using, \" and formulations. C [Continued on next page] WO 2018/052827 Al OII TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))