Patent SG-11201809710R-A (SG)
Title: Genetically engineered cells and methods of making the same
Inventor: SATHER BLYTHE
IPC: C12N15/85
Filed: 2017-05-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 11 11111111111111 01011111011101111111101111110H01111111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/193107 A3 09 November 2017 (09 11.2017) WIP0 I PCT (51) International Patent Classification: Third Street, First Floor, Cambridge, MA 02142 (US). C07K 14/725 (2006.01) C12N 15/85 (2006.01) JONES, Jon; 307 Westlake Ave North, Suite 300, Seattle, C12N 9/22 (2006.01) WA 98109 (US). MAEDER, Morgan, L.; 300 Third Street, (21) International Application Number: First Floor, Cambridge, MA 02142 (US). NYE, Chris; 307 PCT/US2017/031464 Westlake Ave North, Suite 300, Seattle, WA 98109 (US). RUBIO, Eugenio, Marco; 300 Third Street, First Floor, (22) International Filing Date: Cambridge, MA 02142 (US). SALMON, Ruth; 307 West- 06 May 2017 (06.05.2017) lake Ave North, Suite 300, Seattle, WA 98109 (US). (25) Filing Language: English (74) Agent: POTTER, Karen et al.; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA (26) Publication Language: English 92130-2040 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/333,144 06 May 2016 (06.05.2016) US kind of national protection available): AE, AG, AL, AM, 62/332,657 06 May 2016 (06.05.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (71) Applicants: JUNO THERAPEUTICS, INC. [US/US]; CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 307 Westlake Ave, North, Suite 300, Seattle, WA 98109 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (US). EDITAS MEDICINE, INC. [US/US]; 300 Third HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, Street, First Floor, Cambridge, MA 02142 (US). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (72) Inventors: SATHER, Blythe; 307 Westlake Ave North, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Suite 300, Seattle, WA 98109 (US). WELSTEAD, G., = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = Grant; 300 Third Street, First Floor, Cambridge, MA 02142 TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (US). BUMCROT, David, A.; 300 Third Street, First Floor, = Cambridge, MA 02142 (US). FRIEDLAND, Ari, E.; 300 (54) Title: GENETICALLY ENGINEERED = = = 25 = = = = 15 g = CELLS AND METHODS OF MAKING THE SAME 10 = = = I ...... ...... rn — r?\" M IN © FIG, 15 ,—, M cr, ,—, IN I l (57) : Provided are CRIS PR/CAS -related methods, compositions and components for editing a target nucleic acid sequence, or C:::: ) modulating expression of a target nucleic acid sequence, and applications thereof in connection with cancer immunotherapy comprising ei adoptive transfer of engineered T cells or T cell precursors. [Continued on next page] WO 2017/193107 A3 MIDEDIMOMOIDEIROIDEMOMOHNOMMINERE# (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 04 January 2018 (04.01.2018)