Patent AU-2013202305-B2 (AU)
Title: Methods for treating cancer using TOR kinase inhibitor combination therapy
Inventor: XU SHUICHAN
IPC: A61P35/00
Filed: 2013-02-22
Granted: 2015-03-12
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/126636 A1 29 August 2013 (29.08.2013) W I PO I P CT (51) International Patent Classification: Howard Ave., Burlingame, CA 94010 (US). TRAN, Tam, A61K 45/06 (2006.01) A61K31/52 (2006.01) Minh; 9435 Maler Road, San Diego, CA 92129 (US). A61K31/437 (2006.01) A61K31/522 (2006.01) (74) Agents: INSOGNA, Anthony, M. et al.; Jones Day, 222 A61K31/517 (2006.01) A61K31/706 (2006.01) East 41st Street, New York, NY 100 17-6702 (US). A61K 31/519 (2006.01) A61P 35/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2013/027235 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, 22 February 2013 (22.02.2013) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (25) Filing Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (26) Publication Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (30) Priority Data: TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 61/603,012 24 February 2012 (24.02.2012) US ZM, ZW. 61/716,424 19 October 2012 (19.10.2012) US 61/725,805 13 November 2012 (13.11.2012) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: SIGNAL PHARMACEUTICALS, LLC GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, [US/US]; 10300 Campus Point Drive, Suite 100, San UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Diego, CA 92121 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: XU, Shuichan; 12426 Dormouse Road, San EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Diego, CA 92129 (US). HEGE, Kristen, Mae; 616 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] (54) Title: METHODS FOR TREATING NON- SMALL CELL LUNG CANCER USING TOR KINASE INHIBITOR COMBINA TION THERAPY (57) Abstract: Provided herein are methods for treating or preventing advanced non-small cell lung cancer, comprising H1755 SeqM2 at 1:10 ratio (Compound1:azacitidine) administering an effective amount of a TOR kinase inhibitor 1.1 and an effective amount of erlotinib or a cytidine analog to a 09 Cl=0.65 1.0 Isobologrom patient having advanced non-small cell lung cancer. 0.5 - - - - - 0.4 20.4 -AE synergy 0.3 Cmpdl alone:. I I I 0.2s 0.2 5-Aza alone:. I I 0 01 Combo:. 0 0.2 0.4 0.6 0.8 0.001 0.1 10 x ED50 5-Aza [Compound1] y M H1755 SeqM2 at 1:3 ratio (Compound1:azacitidine) 0.9 1.0 Isobologram 0.8 - C1=0.60 : 0.8 0.7- a 0.5 - 0.4 0 3 Cmpdl alone:. I . synergy 0.2 5-Aza alone:. I I x 0.1 -Combo:. 0 00. 10 0 0.2 0.4 0.6 0.8 0.001 0.1 10 5-Aza [Compound1] y M x ED50 W O 2 0 13 /12 6 6 3 6 A 1|l l ll|l|llll l || ||| |||||||||||||||||||I|||||||||||||||||||||||I|||||||||||||||| TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW' - before the expiration of the time limit for amending the ML, MR, NE, SN, TD, TG). claims and to be republished in the event of receipt of Published: amendments (Rule 48.2(h)) - with international search report (Art. 21(3))