baber/WOPTO huggingface dataset:
Patent JP-H11504385-A (JP)
IPC: C10L9/10
Filed: 1997-12-19
Abstract: Disclosed is a method for increasing the charring ratio of coal. In manufacturing an ingot iron using the coal, magnesium oxide or limestone is used as an additive for charring the coal. The additive increases the charring ratio of the coal while giving no affection onto slag. An MgO suspension or limestone suspension is mixed with the coal and thus obtained mixture is dried to attach MgO or the limestone onto the surface of the coal. The charring effect is increased and the using amount of coke can be reduced.
Patent JP-H11502929-A (JP)
Title: 高いデータ速度で動作している自動試験装置のためのタイミング発生器
IPC: H03K5/13
Filed: 1995-12-05
Abstract: (57)【要約】
プログラム可能なタイミング発生器を備えた自動試験装置である。このタイミング発生器では、要求される遅延は、粗遅延、周波数調節遅延及び精細遅延に分解される。連続的なサイクルに対する精細遅延は、記憶される。粗遅延が経過すると、精細遅延は、検索され、エッジ信号を発生するのに用いられる。周波数調整遅延は、精細遅延が粗遅延の分解能の一部によって検索される時間をオフセットするのに用いられる。この調節により、精細遅延の値は、要求される遅延を表す信号が発生されるよりも高速で検索されることが可能になる。この構成によって、エッジを、タイミング発生器の多くがより低速の動作周波数を有する回路を用いて実現されている場合でも、高周波のバースト・モードで発生することができる。より低速の動作周波数の安価な素子を用いて高周波動作が得られることによって、結果的に、著しいコストの削減が達成される。
Patent JP-H10500195-A (JP)
IPC: B60K17/28
Filed: 1995-05-06
Abstract: PCT No. PCT/EP95/01721 Sec. 371 Date Nov. 12, 1996 Sec. 102(e) Date Nov. 12, 1996 PCT Filed May 6, 1995 PCT Pub. No. WO95/31654 PCT Pub. Date Nov. 23, 1995A multi ratio reversing powershiftable transmission having an input shaft, an output shaft, a plurality of countershafts, a drive wheel set, a distribution wheel set and a driven wheel set. The set of drive wheels includes a driven idler gear on each countershaft which can be optionally non-rotatably connected with the contershaft to cause a change of gear and direction of the transmission. The set of distribution wheels consist of at least one fixed gear on each countershaft for commutating rotation between communicating countershafts and the fixed gears of the set of driven wheels which in turn drive the output shaft.
Patent JP-2000512534-A (JP)
IPC: B26B19/06
Filed: 1998-03-23
Abstract: In a hair-cutting apparatus (1) and in a toothed cutting device (7) for a hair-cutting apparatus (1) the toothed cutting device (7) comprises a first toothed cutter (13) and a second toothed cutter (24), which lie against one another in the area of their cuttertooth rows (18, 25) and which each have at least one supporting limb (20, 21, 46, 47) in their areas which are remote from their cutter-tooth rows (18, 25), and of which one toothed cutter (24) carries an intermediate element (48) of a low-friction material, which comprises at least one intermediate element portion (49, 50) interposed between two facing supporting limbs (20, 46, 21, 47), and furthermore it has the advantageous feature that the at least one intermediate element portion (49, 50) of the intermediate element (48) carried by the one toothed cutter (24) has a smaller dimension in the toothed cutter direction (17) than the at least one supporting limb (20, 21) of the other toothed cutter (13), which last-mentioned limb 20, 21 faces the at least one intermediate element portion (49, 50).
Patent JP-H09504153-A (JP)
IPC: H04W52/40
Filed: 1995-05-10
Abstract: PCT No. PCT/FI95/00249 Sec. 371 Date Apr. 4, 1996 Sec. 102(e) Date Apr. 4, 1996 PCT Filed May 10, 1995 PCT Pub. No. WO95/31879 PCT Pub. Date Nov. 23, 1995A method and an arrangement for controlling transmitting power of a mobile station and carrying out a handover in a mobile telecommunications system in which data is transmitted over the radio path between a mobile station and a base station as bursts in time slots of successive frames. A mobile station can be allocated at least two time slots in each frame for high-speed data transmission. The mobile station is arranged to measure the characteristics of the received signal, such as the signal level and/or quality, in each time slot allocated to the mobile station, and the fixed radio network is arranged to control the transmitting power of the mobile station and/or make the decision on a handover on the basis of a combination of measurement results of two or more time slots, or on the basis of the measurement result of the poorest time slot.
Patent JP-H11503071-A (JP)
IPC: B05B15/52
Filed: 1996-02-28
Abstract: A hollow body having a nozzle opening to discharge fluid as a jet or spray; the body comprising a first part having an inlet to admit fluid under pressure into the first part, and a second part movable relative to the first part and said first and second parts are relatively movable from an abutting position in which they define therebetween the nozzle opening and a fluid feed passage in the body and leading to the nozzle opening, and a cleaning position in which the fluid feed passage is split open longitudinally and the nozzle opening is split open to expose the nozzle and passage defining and abutting surfaces of said parts, for cleaning.
Patent JP-H10500693-A (JP)
Title: 改変型インスリン様増殖因子
IPC: C07K14/65
Filed: 1995-05-24
Abstract: (57)【要約】
向上した薬理学的特性と生物特性とを有する改変型インスリン様増殖因子（ＩＧＦ）を提供する。この改変型は、天然型ＩＧＦのアミノ酸配列におけるシステインの置換又は付加によって産生されるＩＧＦムテインと、遊離システイン部位においてポリエチレングリコール（ＰＥＧ）に結合させたＩＧＦムテインとを含む。この発明は更に、このような改変型を製造する方法も提供する。ＩＧＦ−ＰＥＧ結合体を、医薬組成物に配合し、ＩＧＦ関連疾患の治療のために使用することが可能である。
Patent JP-2000506729-A (JP)
IPC: C12N15/09
Filed: 1997-03-11
Abstract: An IGF-I polypeptide or functional derivative thereof characterized by the presence of the Ec peptide or functional equivalent thereof for use in a method of treatment or therapy of the human or animal body.
Patent JP-2000507892-A (JP)
Title: 新規なエラストマー複合体、その製法および装置
IPC: B01F5/02
Filed: 1997-03-25
Abstract: (57)【要約】
混合ゾーンから凝固ゴムゾーンを通って反応装置の排出端部まで半拘束流の形の混合物を連続的に形成するべく凝固ゴム反応装置の混合ゾーンに微粒子を充てん材とエラストマーラテックスの流体流が供給される、新しい連続流方法及び装置により、エラストマー複合体が製造される。該微粒子充てん材流体は、排出端部に至る前に微粒子充てん材でエラストマーを実質的に完全に凝固するべく充分活発にエラストマーラテックス流体を巻込むためジェットストリームを形成するような形で、混合ゾーンに対し高圧下で供給される。酸又は塩溶液などに対する露呈が関与する凝固段階を必要とせずに、効率の高い有効なエラストマー凝固が達成される。新規なエラストマー複合体が製造される。かかる新規なエラストマー複合体は、硬化させても又はさせなくてもよく、充てん材の選択、エラストマー、充てん材投入レベル及びマクロ分散といったこれまで達成されたことのない材料特性を組合わせるものである。
Patent JP-2001515675-A (JP)
Title: テレビジョン番組用のオーディオ及びビデオ設定値の自動制御システム並びに方法
IPC: H04N5/44
Filed: 1998-03-05
Abstract: (57)【要約】
ビデオ設定値及びオーディオ設定値のようなテレビジョン受像機の特性を、視聴される番組の特性に基づいて自動的に調節するシステム及び方法が開示される。システムは、テレビジョンデータベースに格納された予め定義された番組トピックス及びテーマのリストにアクセスする（ステップ１６）。各トピック及びテーマ毎に、コントラスト、色及び輝度のような画質用設定値、並びに、オーディオプロセッサタイプ、低音域及び高音域のようなオーディオ用設定値が記憶される。システムが、現在視聴されている番組をデータベースの中の一つの番組と対照できるとき、オーディオ及びビデオ設定値は、その番組に対する設定値に自動的に調節される（ステップ２２）。視聴者が別の番組に切り換えたとき、或いは、ある番組が終了して別の番組が開始したとき、上記の取得及び調節処理が繰り返される。このシステムは、必要に応じて視聴者によって動作が抑制され得る。
Patent JP-2000510187-A (JP)
Title: アクリルポリマー化合物
IPC: C08J5/18
Filed: 1997-05-02
Abstract: (57)【要約】
炭素原子数が１〜１２のアルキル基を有するメタクリル酸アルキルエステル、および炭素原子数が１〜１２のアルキル基を有するアクリル酸アルキルエステル、置換または非置換のメタクリル酸またはアクリル酸のアリルエステル、置換または非置換のメタクリル酸またはアクリル酸の脂環式エステル、置換または非置換のメタクリル酸またはアクリル酸の環状エステル、重合可能な芳香族ビニルモノマー、ビニルピロリドンあるいは上記モノマー類のいずれかの混合物が約５５〜８０重量％で、メタクリル酸アセトアセトキシエチルエステルを約５〜４０重量％およびエチレン系不飽和酸を約５〜１５重量％含むモノマーを重合させたアクリルポリマーであり、しかもそのアクリルポリマーは約１０，０００〜３，０００，０００の重量平均分子量および約−２０〜５０℃のガラス転移温度を有する。
Patent JP-2000512833-A (JP)
Title: 単眼視キューの統合による奥行き知覚の改善
IPC: H04N5/262
Filed: 1998-03-09
Abstract: (57)【要約】
一つ以上の単眼視キューをオリジナル画像から抽出して組み合わせ、奥行き効果を向上させる。オリジナル画像を獲得し、一つ以上のオブジェクトにセグメンテーションする。オブジェクトが、前景または背景のいずれに存在するかが識別され、注目オブジェクトが識別される。次に、一つ以上の奥行きキュー、たとえば、陰影、輝度、ぼかし、および遮蔽などをオリジナル画像より抽出する。奥行きキューは、改善された奥行き効果を有する一つ以上の中間画像とすることができる。次に、奥行きキューが、組み合わされ、または適用され、奥行き効果を向上させた画像が生成される。
Patent JP-2001507420-A (JP)
Title: 相変化材料を使用する建物の空調技術
IPC: F24D11/00
Filed: 1998-03-25
Abstract: (57)【要約】
天井、フロア、壁、及び少なくとも一つの扉及び一つの窓を持つ部屋のフロアから天井までの温度勾配を小さくするための技術は、天井の表面と隣接した相変化材料及びフロアの表面と隣接した相変化材料を使用する工程を含む。部屋のフロアから天井までの温度勾配を小さくするため、第１及び第２の相変化材料は同じであるか又は異なり、或いは相変化材料の混合物であるかのいずれかである。最も好ましくは、天井と隣接した第１相変化材料の融点は、フロアと隣接した第２相変化材料の結晶点よりも高い。好ましくは、第１相変化材料の融点は２５℃±１℃であり、第２相変化材料の結晶点は２２℃±１℃である。
Patent JP-2002511206-A (JP)
Title: 電話機で加入者サービスを行う方法および装置
IPC: H04M11/00
Filed: 1998-03-12
Abstract: (57)【要約】
サービス・プロバイダと通信する電話機中で、利用可能な加入者サービスをサービス・プロバイダから受ける方法と装置が提供される。この方法は、電話機で加入者サービス・メッセージを受け取るステップを含む。加入者サービス・メッセージは、電話機で利用可能な複数の機能のうち少なくとも１つを識別する機能識別子と、機能が電話機で使用可能となるかどうかを制御する機能制御器を含む。またこの方法は、電話機で使用可能な機能の指示を含む表示メッセージを電話機に表示して、電話機のユーザによって選択された使用可能な機能と関連づけられた機能要求コードを、サービス・プロバイダに送るステップを含む。加入者サービス要求は、サービス・プロバイダに、ユーザによって選択された使用可能な機能の要求を知らせる。その後、使用可能な機能は、電話局から電話機に供給される。
Patent JP-2002508789-A (JP)
Title: 食品調理器の表面からの油および脂肪を除去するための組成物および方法
IPC: C11D3/04
Filed: 1998-04-06
Abstract: (57)【要約】
本発明は、食品加工器の表面から油および脂肪を含む汚れを除去する方法である。本方法は、二部性濃縮物より清浄組成物を調製する工程を含む。濃縮物の第一部分は、アルカリ性源および水を含む。濃縮物の第二部分は、第四アンモニウム化合物を含む。調製後、清浄組成物は、主要部分である水、約１００ｐｐｍから２０，０００ｐｐｍの第四アンモニウム化合物および約１０から１４のｐＨを与えるための濃度で存在するアルカリ性源を有する。調製後、清浄組成物は、食品加工器の表面に適用して用いることができる。清浄組成物はまた、キレート剤および第２の非イオン性または陰イオン性洗浄作用剤を含んでもよい。
Patent JP-2002506602-A (JP)
Title: シグマ−デルタ変調器を有するビデオレートｄ−ａ変換器
IPC: H04H20/00
Filed: 1999-04-12
Abstract: (57)【要約】
補間手段（１）と、フィルタ手段とを有するＤ‐Ａ変換器に関する。このＤ‐Ａ変換器は更に、低減サンプルレート（ＲＳＲ）のシグマ‐デルタ変調器として構成され且つクロック手段により制御される雑音整形器（３）を有する。本発明の有利な例でＤ‐Ａ変換器の動作を更に改善するには、前記フィルタ手段を多相ＦＩＲフィルタ手段として構成する。
Patent MX-162595-A (MX)
Inventor: RITT HANS GEORG
IPC: C03B23/18
Filed: 1983-11-04
Abstract: The present invention relates to a new method of making tubular vials and ampules from glass tubing. The method according to this invention is essentially characterized in that the glass tubing used is closed at both ends and has a dot-shaped opening close to one of the sealed ends. The opening can be sealed by a film to prevent impurities from entering the glass tubing. Throughout the operational process in the production of vials and ampules, a slight excess pressure exists in the glass tubing by applying heat, which further prevents impurities from entering the glass tubing.
Patent MX-156740-A (MX)
Inventor: KUTARAGI KEN
IPC: G11B20/18
Filed: 1985-05-21
Abstract: A magnetic disc reproducing apparatus, for reproducing information signals from one of a plurality of tracks of a magnetic disc, includes a transducer (21) positioned in transducing relation with the plurality of tracks for reading out the information signals of the tracks, a checking circuit (45, 52) connected to the transducer (21) for checking a portion of the information signals, and an identifying circuit (53) connected to the checking circuit (45, 52) for identifying characteristics of the information signals being reproduced.
Patent NZ-197017-A (NZ)
Title: 4-(halo or amino)acyl)-9,10-dihydro-4h-thieno(3,4-b)(1,5)benzodizepin-10-ones
Inventor: FIGALA V
IPC: C07D495/04
Filed: 1981-05-06
Abstract: The new compounds, defined as thieno-benzodiazepinones, are represented by the general formula I,  (FORMULA)  wherein R<s1>s represents a hydrogen atom or an alkyl residue from C<u1>u to C<u4>u, R<s2>s represents a halogen atom or has the same representation as R<s1>s, and R<s3>s represents a halogen atom or a group-N (R<s4>s)R<s5>s, wherein R<s4>s represents an alkyl residue from C<u1>u to C<u4>u or an alkenyl residue from C<u3>u to C<u5>u and wherein R<s5>s has one of the representations of R<s4>s or represents a group having the partial formula -(CH<u2>u)<um>u-N (R<s6>s)R<s7>s, or wherein R<s4>s and R<s5>s in common, including the nitrogen atom to which they are bound, represent a morpholino, pyrrolidino, piperidino group, a hexa-hydro-azepin-1-yl group, a piperazine-1-yl group optionally substituted in position 4 by methyl or ethyl or benzyl, a 2, 4-dimethyl-piperazine-1-yl group or an hexa-hydro-1H-1, 4-diazepin-1-yl group substituted in position 4 by methyl or ethyl, the symbol R<s6>s representing an alkyl group in C<u1>u to C<u4>u and R<s7>s representing an alkyl group in C<u1>u to C<u4>u, the symbol A of the formula I represents an alkylen group with a straight or branched chain C<u1>u to C<u5>u and the symbol m hereabove is 2 or 3; their addition salts may also be formed. All these compounds exhibit a pharmacologic activity for the protection of the stomach and intestine organs and are therefore appropriate for the treatment of diseases affecting the stomach or intestine organs; these compounds may also be used as intermediary products. There are also disclosed methods for the preparation of said new compounds which exhibit an interesting pharmacological activity and also form intermediary products.
Patent NZ-200085-A (NZ)
Title: 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5,5)-u decan-3-ones
Inventor: CLARK R D
IPC: C07D498/10
Filed: 1982-03-22
Abstract: Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula   <IMAGE> (I) wherein: R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and the pharmaceutically acceptable acid addition salts thereof.
Patent NZ-212030-A (NZ)
Title: Hydrogel device for slow release of active agents
Inventor: LEE P I
IPC: A61K9/22
Filed: 1985-05-09
Abstract: An active agent containing controlled release diffusion jevice comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute laving a stable concentration distribution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, releases said active agent in a controlled continuous manner by diffusion for a predetermined period of time, a method of preparing such a device, and the use thereof to release an active agent into the intended environment of use.
Patent NZ-219549-A (NZ)
Title: Hybrid interferons comprising part of an a-interferon and part of an l-interferon and pharmaceutical compositions
Inventor: HAUPTMANN RUDOLF
IPC: A61K45/00
Filed: 1987-03-09
Abstract: The invention relates to novel hybrid interferons comprising part of an  alpha -interferon and part of an omega-interferon, the N-terminal Met- or N-formyl-Met derivatives of these interferons and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives of these interferons, their use as medicaments and as intermediates for the immunisation of test animals and the preparation of these interferons, novel monoclonal antibodies and their use for the purification of  alpha - and omega-interferons, the hybrid cell lines secreting them, and the preparation of these hybrid cell lines, a novel purification procedure for  alpha - and omega-interferons with the aid of a novel antibody affinity column containing the abovementioned novel monoclonal antibodies, and the preparation of these antibodies, novel hybrid plasmids for improving the expression of the omega-interferons, and novel intermediate plasmids for preparing the novel plasmids, and their preparation.
Patent NZ-220914-A (NZ)
Title: Acyl derivatives of cephalosporin compounds and pharmaceutical compositions
Inventor: ALBRECHT HARRY ALLEN
IPC: C07D501/34
Filed: 1987-07-01
Abstract: Cephalosporin derivatives of the formula <IMAGE> in which m represents 0, 1 or 2, R<1> represents hydrogen or an acyl group, R<2> represents hydrogen, lower alkoxy, amino, lower alkylthio or lower alkanoylamino, R<3><1> represents hydrogen, lower alkyl, lower alkenyl, C3-C7-cycloalkyl, halogen-lower alkyl or halophenyl; Z represents R<3><0>-C or nitrogen, R<3><0> represents hydrogen or halogen, or R<3><0> and R<3><1> together represent a C3-C5-alkylene group, a C2-C4-alkylene- monooxy group or a C1-C2-alkylenedioxy group, R<3><2> represents hydrogen, halogen, lower alkyl or an optionally substituted 5- or 6-membered heterocyclic ring having one, two or three oxygen, nitrogen and/or sulphur atoms and R<3><3> represents hydrogen or halogen or R<3><2> and R<3><3> together represent a C1-C4-alkylenedioxy group, and easily hydrolysable esters and salts of these compounds and hydrates of the compounds of the formula I or of their esters and salts are described. The products have antimicrobial activity.
Patent NZ-221334-A (NZ)
Title: Optical cable with optical fibre in strength member interstices
Inventor: PEACOCK A J
IPC: G02B6/44
Filed: 1987-08-04
Abstract: An optical fibre cable, especially an aerial cable, has, within an outer sheath (3), four or five strength members (1) with at least one optical fibre package (6, 6.1) accommodated in an interstitial space formed by the strength members (1). Such a cable can be constructed to have sufficient tensile strength for installation between towers up to 1000m apart.
Patent NZ-225066-A (NZ)
Title: Solid drug preparations containing 2-phenyl-1,2-benzisoselenazol-3(2h)-one (ebselen)
Inventor: ROMER AXEL
IPC: A61K9/14
Filed: 1988-06-17
Abstract: Solid pharmaceutical compositions containing 2-phenyl-1,2-benzisoselenazol-3(2H)-one (EBSELEN) with high bioavailability thereof contain EBSELEN in the form of micronised crystals of EBSELEN and are prepared as described.
Patent NZ-231029-A (NZ)
Title: Substituted pyrrolidinyl chroman derivatives and pharmaceutical compositions
Inventor: REGNIER GILBERT
IPC: C07D405/04
Filed: 1989-10-16
Abstract: New aminochromanol compounds of the formula:   <IMAGE> (I)   <IMAGE> in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl; CH2-R is attached (in the 5 position of the pyrrolidinone nucleus) to an R- or S-configured carbon atom, and R is: either OR' or SR' in which R' is hydrogen, (C1-C10)-alkyl, (C1-C5-alkyl)-carbonyl or   <IMAGE>  and physiologically tolerable acid addition salts thereof, in the case where R contains a basic function. These compounds and their physiologically tolerable salts can be used in therapeutics for the activation of potassium channels, especially in the treatment of disorders associated with abnormal smooth muscle contraction and in the cardiovascular, bronchopulmonary, digestive, urinary and uterine fields.
Patent NZ-236032-A (NZ)
Title: Napthacenedione derivatives, their preparation and pharmaceutical compositions
Inventor: GIOLITTI ALESSANDRO
IPC: A61K31/122
Filed: 1990-11-12
Abstract: New 7-substituted fluoro-2 beta -acetyl-2 alpha ,4 alpha ,5,12-tetrahydroxy-1,2,3,4-tetrahydro-6,11-naphthacenedion es having the general formula I: <CHEM> where X is a hydrogen atom, or a hydroxyl group, R and R1, which cannot be equal, are a hydrogen atom or a fluorine atom; R2 can be hydrogen atom or a hydroxyl group or an alkoxy group. These fluoro-naphthacenediones can be useful for obtaining new derivatives which show a different reactivity of the 2 alpha  hydroxyl, in particular new anthracyclines.
Patent NZ-238245-A (NZ)
Title: Remote utility meter reading: encoded interrogation signal
Inventor: BRENNAN WILLIAM J
IPC: H04L69/14
Filed: 1991-05-23
Abstract: A two wire/three wire utility data communications system for remotely reading utility meter registers. In the two wire version, a hand-held reading unit is inductively coupled over two wires via a port located remotely from a meter register. Alternatively, a meter interface unit (MIU) may be connected directly to the register via three wires. Each register includes one or more wheel position encoders. An AC interrogation signal is applied by the reading unit to encoder circuitry at the meter which powers the circuitry and causes the position of each encoder wheel to be read. In the two wire mode, register display information (e.g. the current meter reading) is transmitted back to the reading unit by varying the load (impedance) presented by the register side of the circuit. This causes a corresponding variation of the amount of current drawn from the reading unit. The current-modulated signal is decoded by the reading unit and converted into a register reading. The system can also operate in a three wire mode and read older fourteen wire encoded registers. Other features include remote programmability of register characteristics, the ability to interrogate multiple registers which share a common data bus, verification of encoder wheel positions before accepting a reading, real-time flow rate/leak detection, pulse output, and the capability of reading compound meters (i.e. meters having two registers to separately measure high/low flow rates). <IMAGE>
Patent NZ-238644-A (NZ)
Title: 2-(1-oxo-alkoxy)alkanoic acid derivatives and pharmaceutical compositions thereof
Inventor: BAXTER ANDREW JOHN GILBY
IPC: A61K31/22
Filed: 1991-06-21
Abstract: PCT No. PCT/GB91/00980 Sec. 371 Date Dec. 10, 1992 Sec. 102(e) Date Dec. 10, 1992 PCT Filed Jun. 18, 1991 PCT Pub. No. WO92/00276 PCT Pub. Date Jan. 9, 1992.Angiotensin converting enzyme inhibitors have the formula Z(CH2)nCHR1COOCHR2COOH in which Z is -SR3, -COCHR4NHCOR5,   <IMAGE>    or -NHCHR7COOH, R4, R5, R6, and R7, which may be the same or different, are each phenyl or alkylphenyl C7-12, R4 is hydrogen, alkyl C1-6, NHR8 or (CH2)pR9, R2 is (CH2)mXR10, alkyl C1-6 optionally substituted by a saturated 5- or 6-membered carbocyclic or heterocyclic ring, alkylhalo C1-6, alkylcyano C1-6, or alkyl phenyl C7-12, the phenyl being optionally substituted by NO2 or NH2, X is O, S(O)q, C=O or NR11, and R10 is alkyl C1-6, alkylhalo C1-6, alkoxy C1-6, alkoxy C1-6 substituted by halogen, alkanoyl C1-6, S(O)rR12, NR13R14, phenyl, alkylphenyl C7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring, n is an integer from 0 to 6, m and p, which may be the same or different, are each an integer from 1 to 6, R9 is hydrogen, SR15 or phenyl optionally substituted by OR16, R3 and R15, which may be the same or different, are each hydrogen or alkanoyl C1-6, R8 is hydrogen or COOR17, q and r, which may be the same or different, are each 0, 1, or 2, R11, R13, R14, R16, and R17, which may be the same or different, are each hydrogen or alkyl C1-6, and R12 is hydrogen, alkyl C1-6 or phenyl. The compounds, and salts thereof, are useful as vasodilators.
Patent NZ-238774-A (NZ)
Title: 9-purinyl phosphonic acid derivatives and their use as pharmaceutical agents
Inventor: HALAZY SERGE
IPC: C07F9/6561
Filed: 1991-06-28
Abstract: This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.
Patent NZ-240014-A (NZ)
Title: Aprotinin analogues and their production
Inventor: NORSKOV-LAURITSEN LEIF
IPC: A61K38/57
Filed: 1991-09-30
Abstract: Aprotinin analogues (I) with reduced nephrotoxicity and with a reduced position net charge, provided as follows, are claimed: (1) at least one positively charged aminoacid residue outside the protease binding site is removed or replaced with a neutral or negatively charged aminoacid residue; and/or (2) at least one negatively charged aminoacid residue is inserted or added; and/or (3) at least one neutral aminoacid residue is replaced with a negatively charged aminoacid residue; and/or (4) to provide reduced stability, one or more aminoacid residues are deleted, added or replaced with one or more other aminoacid residues.
Patent NZ-257873-A (NZ)
Title: Absorbent article has a surface web joined to a surface layer and an absorbent pad; surface web is multilayered with decreasing denier
Inventor: KOCZAB JEAN-PIERRE
IPC: D04H13/00
Filed: 1993-11-18
Abstract: Multilayer nonwoven material which has a high rate of drying out, improved rate of entry of, or break-through time by, body fluids and good diffusion of the body fluids in the plane of the layers, comprises at least two superposed layers (1, 2) of natural or synthetic textile fibers, joined together, the fibers of the successive layers having a denier decreasing progressively, in a given direction, from one successive layer to the other. <IMAGE>