Patent SG-11201809799W-A (SG)
Title: Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions
Inventor: CUEVAS-CORDOBÉS FÉLIX
IPC: C07D498/10
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/191304 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 471/04 (2006.01) A61K 31/551 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 487/04 (2006.01) A61P 29/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, C07D 498/10 (2006.01) A61P 25/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/EP2017/060780 Published: — with international search report (Art. 21(3)) (22) International Filing Date: 05 May 2017 (05.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16382199.4 06 May 2016 (06.05.2016) EP (71) Applicant: LABORATORIOS DEL DR. ESTEVE, S.A. [ES/ES]; Avda. Mare de Deu de Montserrat, 221, 08041 BARCELONA (ES). (72) Inventors: CUEVAS-CORDOBES, Felix; Pza. Her- — mano Ramon Quiroga 2, 4F, 28340 VALDEMORO (Madrid) (ES). ALMANSA-ROSALES, Carmen; c/ — Teodora Lamadrid, n° 41, Ent 4', 08022 BARCELONA = (ES). = Agent: CARPINTERO LOPEZ, Francisco; Herrero & (74) — Asociados, S.L., Cedaceros, 1, 28014 MADRID (ES). — Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (81) — = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = = = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = Title: TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING (54) 1-1 PAIN AND PAIN RELATED CONDITIONS (57) : The present invention relates to new compounds of general formu- 71' en \ la (I) that show great affinity and activity towards the subunit GCS of voltage-gat- ed calcium channels (VGCC), especially a28-1 subunit of voltage-gated calcium __--y 1-1 N\-- '' ''''. 1 channels or dual activity towards subunit GCS of voltage-gated calcium channels 01 N (I) (VGCC), especially ct28-1 subunit of voltage gated calcium channels, and nora- 1-1 drenaline transporter (NET). The invention is also related to the process for the .--\". IN 1-1 NiiVx R2 preparation of said compounds as well as to compositions comprising them, and © ei i to their use as medicaments. (I) C