baber/WOPTO huggingface dataset:
Patent CR-20220037-A (CR)
Title: IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
Inventor: MAY-DRACKA TRICIA
IPC: C07D519/00
Filed: 2020-06-24
Abstract: This invention relates to Imidazo[l,2-a]pyridinyl Derivatives of formula (I'), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.
Patent EC-SP045451-A (EC)
Title: Metodos y formas de dosificacion para la entrega controlada de oxicodona
IPC: A61K31/485
Filed: 2004-11-24
Abstract: La invención se refiere a una forma de dosificación oral de liberación sostenida para una entrega controlada de oxicodona de una vez al día que comprende: (a) un núcleo que comprende: (i) un agente osmótico, y (ii) oxicodona y una o más sales de adición ácida farmacéuticamente aceptables de la misma (del compuesto); (b) una membrana semipermeable que recubre el núcleo, y (c) un orificio de salida a través de la membrana semipermeable que comunica con el núcleo para permitir la liberación del compuesto hacia el medio; donde la forma de dosificación libera el compuesto durante un período prolongado de tiempo a una velocidad de liberación uniforme, de tal manera que la velocidad promedio de liberación por hora desde el núcleo varía positivamente o negativamente por no más de aproximadamente 30%, ya sea desde la velocidad promedio de liberación por hora precedente o subsiguiente durante un período de tiempo DT uniforme que empieza con el tiempo cuando la liberación acumulativa del compuesto desde el núcleo alcanza aproximadamente 25% y que finaliza con el tiempo cuando la liberación acumulativa del compuesto del núcleo alcanza el 75%.
Patent EC-SP056077-A (EC)
Title: Composición de insulina oral y métodos de fabricación y uso de estos
Inventor: SABETSKY VLADIMIR
IPC: A61K9/16
Filed: 2005-10-04
Abstract: Un método para reducir la glucosa sanguínea en un mamífero incluye administrar oralmente una cantidad terapéuticamente efectiva de micropartículas de dextrán cristalizada e insulina al mamífero para reducir la glucosa sanguínea del mamífero. La composición puede ser una fase o una composición multi-fase estructurada para liberación controlada de insulina.
Patent EC-SP088726-A (EC)
Title: Combinación sinérgica de inhibidores de receptores h2, silicón inerte y un complejo aluminato de hidroximagnesio
Inventor: SANTOS MURILLO JOSEFINA
IPC: A61K31/426
Filed: 2008-09-09
Abstract: La presente invención está relacionada con la industria farmacéutica en general y con la industria farmacéutica preparadora de medicamentos para la prevención y/o tratamiento de la enfermedad ácido péptica y síntomas relacionados con la producción excesiva de ácido en el estómago, además de contribuir a la cicatrización, prevención de recidivas sintomáticas y complicaciones, en particular. Tiene como ventajas con respecto de las composiciones del estado de la técnica, una dosificación más pequeña de cada elemento para evitar o reducir de manera sustantiva los efectos secundarios y con un efecto terapéutico al menos igual a los efectos de los del estado de la técnica. Esta composición está caracterizada porque comprende un agente inhibidor de los receptores de histamina tipo 2; un agente antiflatulento; un agente antiácido, así como excipientes farmacéuticamente aceptables.
Patent FI-20030938-A (FI)
Inventor: TIKKANEN JUHA
IPC: G01N27/62
Filed: 2003-06-24
Abstract: A method and a sensor device for determining particle emissions from exhaust gases of a combustion engine substantially during the use in an exhaust pipe system or a corresponding exhaust gas duct, in which method emitted particles contained in the exhaust gases are charged and the particle emissions are determined by measuring the electric charge carried by the emitted particles in the exhaust gas duct. The emitted particles are charged by varying the way of charging or the charging power with respect to time in such a manner that as a result of the charging, emitted particles brought into at least two different electrical charge states are present, wherein the charge of the emitted particles is further determined as a difference value/values measured from the emitted particles brought into said at least two different electrical charge states.
Patent FR-1600475-A (FR)
IPC: C07C13/02
Filed: 1968-11-15
Granted: 1970-07-27
Abstract: 1,185,936. Macrocyclic compounds. RESEARCH CORP. 24 Sept., 1968 [15 Jan., 1968], No. 45288/68. Heading C2C. [Also in Division C5] Macrocyclic compounds, particularly lactones are prepared by decomposing di- or triperoxides of cyclic ketones having a 5-membered or larger ring by irradiation with ultraviolet light or by heating above 100‹ C. The thermal decomposition may be effected in a sealed tube or by injection into a heated packed column. In examples 11-undecanolactone is obtained from cyclohexanone diperoxide, 13-tridecanolactone from cycloheptanone diperoxide or cyclopentanone triperoxide, 16-hexadecanolactone from cyclohexanone triperoxide and 23- tricosanolactone from cyclododecanone diperoxide. Reference is also made to the production of cyclopentadecanone using a ketosubstituted cyclohexanone triperoxide.
Patent GB-1040161-A (GB)
IPC: C07D487/04
Abstract: 1,040,161. Sulphur-containing derivatives of tetraazaindene. MINNESOTA MINING & MANUFACTURING CO. Jan. 20, 1965 [Jan. 29, 1964; Sept. 4, 1964], Nos. 3850/64 and 36350/64. Heading C2C. [Also in Division G2] The invention comprises tetraazaindene compounds of the general formula wherein R is alkyl, X is hydrogen or cyano and Y is hydrogen or an alkyl, alkylthio or aryl group. Preferred compounds are those in which R and X are as defined above and Y is hydrogen or an alkyl or alkylthio group. They may be prepared by heating, usually between 60‹ and 180‹ C., a 3-amino-1,2,4-triazole of the general formula and a #,#-dialkylthioacrylic ester of the general formula wherein R 1  is alkyl. An organic catalyst may be included in the reaction mixture and then the reaction is normally effected at a temperature below the boiling-point of the acid catalyst. Specified organic catalysts are aliphatic acids, e.g. acetic and pivalic acids, and phenols, e.g. phenol, cresol and xylenol, and their halogenated derivatives. The products have applications in photography in the stabilization of silver halide emulsions (see Division G2).
Patent GB-1046609-A (GB)
Abstract: 1,046,609. Gas igniters. HEINRICH KOPPERS G.m.b.H. Oct. 6, 1965 [Nov. 2, 1964], No. 42358/65. Heading F4T. In an ignition and flame monitoring device, chambers 13 and 14 are fed with air and gas through pipes 22 and 15 respectively and the gases exiting through annular passages 19 and 18 mix in a conically divergent port 11 formed in a refractory brick 7 held opposite a passage 3 in the combustion chamber wall 2 of a blast air heater (not shown). The gas/air mixture is ignited by an ignition plug 17 extending through the gas chamber 14 and into the narrow part 16 of port 11. Air enters pipe 22 through a branch line 20 and the pipe 22 has attached to its outer end a flame monitor 21. Adduct 23 in the refractory brick 7 is arranged as a continuation of the axis of pipe 22 and the monitor 21 and this axis is orientated to intercept the pilot flame in passage 3 and continue into the air heater combustion chamber 1.
Patent GB-1050420-A (GB)
IPC: B21D7/06
Abstract: 1050420 Programmed control of bending UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW 11 Oct 1965 [10 July 1964] 28480/64 Headings B3E E1G and EK In a programme control system for bending a bar to a desired shape by first bending a length of the bar at one end by a bending and gauging operation consisting of applying a transverse bending force to the bar, releasing the bending force and allowing the bar to spring back, gauging the curvature of the bar and applying a correcting force to bring the curvature within a predetermined deviation from the curvature required to provide the desired shape. The remainder of the bar is then bent to the desired shape by further bending and gauging operations consisting of feeding the bar endwise a predetermined distance, applying a transverse bending force to the unbent portion of the bar, releasing the bending force and allowing the bar to spring back, meaning the deviation of the force end of the bar from its calculated position and applying a correcting transverse bending force to bring the actual position of the free end of the bar to within a predetermined distance of the calculated position.
Patent GB-1053357-A (GB)
IPC: B65B11/04
Abstract: 1,053,357. Packaging. RESTELLO A.B. Oct. 4, 1965 [Nov. 7, 1964; April 6, 1965], No. 41975/65. Heading B8C. An apparatus for packing a stack of coins 1 &c., in a heat-shrinkable film 2 comprises a supply roll 18 from which the film is fed and wrapped around the stack 1 as it is rotated by three rollers 10, 11, 12. The coins are fed down a groove 4, Fig. 4 (not shown), or the like, and are stacked in a tube 5 on a stacking plate 6. The plate 6 is fixed to a rod 7 which is fixed to a rotatable table 8. Also on the table 8 are further rods 7a, 7b each provided with a stacking plate and tubes similar to the tube 5 which accommodate other sizes of coins (not further described). Two felt covered rollers 10, 11 are pivoted about an axis A and are arranged to press resiliently against the tube 5. A third feltcovered roller 12 is pivoted about an axis B and is resiliently urged against the tube 5. The rollers are driven by geared wheels 16, 17. When the tube 5 has been filled with coins, the tube is removed to a position 5<SP>1</SP> (shown by dashed lines in Fig. 4) between the rollers 10 ... 12 which now contact the stack of coins 1. The film is then fed by air nozzles 20, 21 and by a guide 19, which may be omitted, between the stack 1 and the roller 10. A pivoted device 24 wets the end of the film, or all the film if desired, with paraffin oil so that the film adheres to the stack. As the film 2 is wrapped around the stack 1 the guide 19 moves along the axis of the stack (in a direction C, Fig. 4), and forms a helical wrapping. When the stack 1 is wrapped, the strip is cut off by a cutting wire 22, and the wrapped stack heated by a wire 23. The package is then pushed out by any suitable means. The film supply roll 18 may be braked to cause a sliding between the felt covered rollers 10 ... 12 and the film 2 so that the film is electrostatically charged and attracted to the stack 1. The stack of coins 1 can alternatively be wrapped in a single turn of film 2a, Figs. 5, 6 (not shown), by exchanging the supply roll 18 for a roll having an axial length greater than the stack of coins. Sheets 2a of film can also be fed by hand to the machine.
Patent GB-1054845-A (GB)
IPC: G01K13/08
Abstract: 1,054,845. Mountings for thermometers. ROSEMOUNT ENGINEERING CO. Ltd. Oct. 5, 1965 [Oct. 5, 1964], No.40495/64. Heading G1D. A device for measuring the temperature of a moving surface 21 comprising a cylinder 11 which rolls along the surface on a shaft 12, the cylinder 11 containing a fluid 19 in which is submerged or the temperature sensitive part 17 of a thermometer 16. The lowermost portion 18 of the cylinder 11 contacts the surface 21 and transmits its temperature to the thermometer 16. The fluid may be a low viscosity liquid or in some cases a gas. A cylindrical member 15 is provided inside the cylinder 11, and the thermometer may be an expansion or resistance thermometer, thermocouple or vapour pressure or gas thermometer. A lagged reflecting shield 23 is mounted over the cylinder 11, and the curved surface of this cylinder may be coated with a resilient material e. plastics material or soft metal to increase the area of contact between the cylinder 11 and the surface 21.
Patent GB-1227056-A (GB)
IPC: H04Q3/00
Filed: 1969-03-28
Abstract: 1,227,056. Automatic exchange systems. SIEMENS A.G. 28 March, 1969 [29 March, 1968; 17 May, 1968], No. 16351/69. Heading H4K. Connections are set up in a telecommunications exchange using switching matrices of latching relays by initially applying a resetting voltage pulse to the respective row and column wires followed by a setting pulse of opposite polarity. As shown, each relay coil KR is connected through a threshold device (varistor) to a row wire xz and directly to a column wire yz. Each row wire is connectible by marker contacts x to a common row marker line U7 and through a decoupling diode Gx, which could be another switch contact, to a common row conductor U6. Similarly each column wire is connected to a common column conductor U8 through a decoupling diode Gy and is connectible by marker contacts y to a common column marker line U9. To set relay KR11 the marker contacts x1 and y1 are closed and the pairs of contacts t11, t12; t21, t22; closed in sequence to energize lines U7, U8; U6, U9 respectively, and reset the row of relays KR11-KR1m and the column KR11- KRn1 accordingly. Contacts t31, t32 are then closed to apply a voltage across lines U7, U9 to set up relay KR11. In a modification, Figs. 1 and 3 (not shown), each column wire is replaced by a pair of subsidiary column wires connected to the relay coil through oppositely poled rectifiers so that one wire transmits a resetting voltage pulse and the other wire a setting voltage pulse. An extra contact is required to mark the setting wire and a common column setting line is provided.
Patent GB-1231809-A (GB)
IPC: F22G5/02
Filed: 1967-12-06
Abstract: 1,231,809. Controlling burners. ASSOCIATED BRITISH COMBUSTION Ltd. 6 Dec., 1968 [6 Dec., 1967], No. 55537/67. Heading F4T. In a boiler unit having a plurality of main burners each being able to be switched independently to only a high or a low fuel loading position, determined by the lowest and highest operating ranges of the boiler loading, the measurement of steam or heat flow from the boiler controls the number of main burners at full and low load. Preferably the burners are operated at constant fuel and air pressures and each is switched between its operating positions by a device controlling the fuel supply to it. To smooth the coarse control thus obtained and to give a constant steam pressure at the boiler outlet, one or more modulating burners comprising either twin fluid or return flow pressure jet types of fuel atomizer are provided, each capable of modulating its output over a range greater than that of one of the main burners. Separately controlled air and fuel is supplied to the modulating burners, which are controlled from a signal received from measurement of the boiler steam pressure. The preferred embodiment shows 22 main burners and two modulating burners.
Patent GB-1234234-A (GB)
IPC: D06M15/423
Filed: 1968-02-13
Abstract: 1,234,234. Treating fabrics of polyester and cellulosic fibres. IMPERIAL CHEMICAL INDUSTRIES Ltd. 30 Jan., 1969 [13 Feb., 1968], No. 6982/68. Heading D1P. [Also in Division C3] A fabric composed of a blend of synthetic, essentially linear crystallisable polyester material and cellulosic material, e.g. cotton, flax or viscose or polynosic rayon, is given improved antisoil and soil release properties by applying thereto (a) a crystallisable polymeric compound which contains within a single molecule sufficient repeat units identical with those forming the crystallisable portions of the synthetic polyester material present in the fabric to confer crystallisability on the compound and at least one polyoxy-alkylene group derived from a polyoxyalkylene glycol having an average molecular weight of 300-6,000, (b) a textile resin capable of being fixed within the fibres of a cellulosic fabric by reaction under acidic conditions with the hydroxyl groups present in the cellulosic material and also of reacting to give a fully cured resin, (c) as catalyst an acid or acid-generating substance, e.g. oxalic acid, zinc chloride or nitrate, a mineral acid salt of an organic amine, ammonium sulphate or chloride, magnesium chloride or ammonium thiocyanate and (d) an ester of glycerol or a polyglycerol with an aliphatic monocarboxylic acid having at least five carbon atoms and optionally containing one or more oxyalkylene groups attached to hydroxyl groups of the glycerol or polyglycerol, and then heating the fabric. The fabric may be treated with the polymeric compound, textile resin, catalyst and glycerol ester in an aqueous medium which may also contain a surface active agent, dried at 50‹-120‹C, optionally made up into a garment, heated at 120‹-220‹C for from 5 seconds to 20 minutes, washed with a hot detergent solution containing soda ash, rinsed and dried. Alternatively the fabric may be treated with the polymeric compound, subjected to heat-setting, and then treated with the textile resin, catalyst and glycerol ester and heated. The crystallisable polymeric compound may contain 10-50% by weight of ethylene terephthalate repeat units and 90-50% by weight of polyoxyethylene terephthalate repeat units derived from a polyoxyethylene glycol of average molecular weight 1000-4000, the molar ratio of ethylene terephthalate to polyoxyethylene terephthalate units being 2:1 to 6.1. The textile resin may be an initial stage condensation product of formaldehyde with urea, an amide, carbamate, uron, urein, ureide, imidazolidinone, pyrimidone or triazone or alkyl ether thereof in which the alkyl group contains 1-3 carbon atoms.
Patent GB-1234540-A (GB)
IPC: F16J15/06
Filed: 1969-09-16
Abstract: 1,234,540. Subaqueous structures; diving chambers. LOCKHEED AIRCRAFT CORP. 16 Sept., 1969 [19 Sept., 1968], No. 44993/69. Heading E1H. A wellhead cellar 25 can be entered by personnel from a diving-chamber 27 through an opening surrounded by an elastomeric annular seal 55 situated above flared skirt 41 and abutting a conic surface 47 on a probe 43 upon the cellar. A cable 35 and winch 37 draw the chamber down to the cellar. When the seal contacts the surface 47 the pressure of water filling a lower compartment 31 is equalized with that of air in a compartment 29 for the personnel by the latter opening a valve 67 communicating with a sump 69. The ambient water then presses the chamber downwards to bring annular surfaces 45, 53 into contact with each other and compress the element 55. Latches 89 secure the chamber to the cellar. The water in the compartment 31 can be removed by a pump 73. A valve 64 is opened to flood the compartment 31 before the chamber is raised.
Patent GB-1238066-A (GB)
IPC: B01D53/50
Filed: 1968-05-14
Abstract: 1,238,066. Recovering sulphur values. NORTH AMERICAN ROCKWELL CORP. 14 May, 1968 [15 May, 1967], No. 38266/70. Divided out of 1,238,062. Heading C1A. Sulphur values are recovered from a molten salt mixture containing alkali metal sulphides by reacting the mixture with carbon dioxide and steam at a temperature below 450 C. at which the salt mixture is molten, preferably 325-425 C. to form alkali metal carbonates and hydrogen sulphide. The process may form part of a sulphur oxides recovery system as described in the parent Specification 1,238,062. A molten alkali metal carbonates containing mixture absorbs sulphur oxides from a flue gas to form a molten alkali metal sulphites and sulphates containing mixture, which is reduced with hydrogen, carbon monxoide or a mixture thereof at a temperature of at least 400 C., preferably 400-700 C., to form the molten alkali metal sulphides containing mixture. The alkali metal sulphite content of the mixture prior to reduction is preferably 10-30 mole per cent. Suitable reducing gases are water gas, producer gas, coal gas, carburetted water gas, carbon dioxide with hydrogen, and carbon monoxide with water. A cobalt molybdate catalyst may be used in the reduction step, and the product gases from that step may be used as the carbon dioxide/steam mixture reacted with the sulphides containing mixture.
Patent GB-1239087-A (GB)
IPC: D05B23/00
Filed: 1969-02-14
Abstract: 1,239,087. Guide. QUICK SERVICE TEXTILES INC. 14 Feb., 1969 [21 Nov., 1968], No. 40950/70. Divided out of 1,239,085. Heading D1G. A sewing machine guide for a strip or strips (24a, 24b) comprises a box like structure having a top wall (61 b), a bottom wall (61a) a fixed side wall (63) extending between those walls, the other side wall of the guide being arranged for movement between a normal position just permitting free movement of the strip and a retracted position increasing the width of the box end, means (75) to retract the said other wall and means (71) to restore the wall to its normal position. The guide is that disclosed in Figures 1, 2 and 3 of the Specification 1,239,085.
Patent GB-1239639-A (GB)
IPC: G06G5/00
Filed: 1968-10-15
Abstract: 1,239,639. Fluidic devices. KLOCKNERHUMBOLDT DEUTZ A. G. Oct. 15, 1968 [Oct. 25, 1967], No.48759/68. Heading G3H. A fluidic function generator has a nest of graded length tubular resistors 17 across which a fluid jet is deflected by two independently variable control pressures which move the jet about X & Y axes so that the pressure P 2  downstream of the resistors is a function of the relative values of the control pressures. Pressure P 2  can be connected to either a control orifice of an amplifier 28, or a pressure gauge (not shown). The fluid jet issues from a conduit 20 connected to a constant pressure source P s  by a bellows 16, and movable by a pair of bellows units 21. In a modification Figs. 5 and 6 (not shown) a fluid stream (24) issuing from a stationary orifice is deflected by a pair of control jets (25,26).
Patent GB-1251926-A (GB)
IPC: B01F27/91
Filed: 1970-05-19
Abstract: 1,251,926. Batch mixers. KOMBINAT PENTACON DRESDEN KAMERAUND KINOWERKE VEB, 19 May, 1970, No. 24162/70. Heading B1C. A device for mixing and pumping liquids comprises a centrifugal or gear pump 3, an impeller 4 and a drive motor 2, the impeller being mounted on a shaft 5 which is coupled to the take-off shaft 8 of the motor and which is axially displaceable on reversal of the motor to engage with or be disengaged from the driving shaft 11 of the pump. The shaft 5 is coupled to the shaft 8 by a pin- and-slot connection 8, 9 and to the shaft 11 by a releasable bayonet type connection, Fig. 2 (not shown). In operation clockwise rotation of the shaft 5 effects only mixing of the liquid by the impeller, and a guide plate 15 aids circulation, while anticlockwise rotation of the shaft 5 effects pumping by the pump 3, the liquid being delivered through a pipe 16. The device may be used for preparing photo-chemicals.
Patent GB-1259468-A (GB)
IPC: C07C46/06
Filed: 1968-12-12
Abstract: 1,259,468. p - Alkyl - p - benzoquinones. EASTMAN KODAK CO. 12 Dec., 1968 [14 Dec., 1967], No. 59125/68. Heading C2C. A process for the oxidation of a polyalkylphenol of the formula  to a polyalkyl-p-benzoquinone of the formula wherein R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP> and R<SP>5</SP> are the same or different and represent a hydrogen atom or an alkyl group, at least two being alkyl, is characterized in that the polyalkyl phenol is dissolved in a solvent and treated with a solution of nitric acid at a temperature of from 5 to 80 C. for a period of time sufficient for the substantial completion of the oxidation.
Patent GB-1264339-A (GB)
IPC: C07D295/14
Filed: 1969-08-01
Abstract: 1,264,339. Choleretic medicines. LABORATOIRES HOUDE. 1 Aug., 1969 [6 Aug., 1968], No. 38755/69. Heading A5B. [Also in Division C2] Pharmaceutical compositions having choleretic activity and in conventional solid or liquid forms for oral administration comprise one or more compounds of formula in which B is a straight-chain or branchedchain alkylene radical having two or three carbon atoms, n is zero or 1, R 1  is an alkyl radical, R 2  and R 3  are the same or different and are hydrogen or alkyl, or, together with the nitrogen atom to which they are attached, form a five- or six-membered heterocyclic ring and a therapeutically administerable vehicle.