Patent GB-505429-A (GB)
Title: Improvements in or relating to the manufacture and use of disinfecting and like agents
IPC: C11D3/48
Filed: 1937-07-29
Abstract: 505,429. Disinfectants ; wetting and cleansing compositions ; quaternary ammonium compounds. DEHN, F. B. (Deutsche Hydrierwerke Akt.-Ges.) July 29, 1937, No. 21024. [Class 81 (i)] [Also in Groups III and IV] Disinfectant, preservative and wetting compositions are prepared by mixing one or more compounds of the general formula Am.R.CO. NHR<1>, in which Am represents a quaternary ammonium group containing any desired anion, R represents a substituted or unsubstituted hydrocarbon residue containing less than 8 carbon atoms, and R<1> a lipophile hydrocarbon residue containing at least 6 carbon atoms, with one or more of the following substances, viz. soaps, soap substitutes, alkalinereacting cleansing, agents, and alkaline-reacting salts. Disinfectants and anti-corrosive agents such as aromatic amines, organic liquid diluents such as mono- or polyvalent alcohols, and solid diluents such as inorganic salts; may also be.added. The ingredients are mixed without added water but the mixtures are used in aqueous solution. In the molecule of the active substance the ammonium group may contain similar or mixed aliphatic, aromatic, aliphatic-aromatic or heterocyclic residues such as a piperidine or pyrrolidine ring ; the residue R may be CH3, C2H5, C6H5.CH2 or C3H7, the residue R<1> may be an aliphatic hydrocarbon, oxyoctadecanyl, cyclohexyl, alkylatod cyclohexyl, naphthenyl, abietyl, alkylated phenyl, benzyl or like residue. Particularly effective disinfectants compounds contain an unsaturated residue such as benzyl or allyl . in the quaternary ammonium group or at the nitrogen atom of the amide group. Examples of soap substitutes are fatty alcohol sulphonates or sulphates, alkyl sulphonic acids, esters of hydroxyethane sulphonic acids, acid amides of amidoethane sulphonic acids, quaternary ammonium compounds containing high molecular hydrocarbon residues, and addition products of alkylene oxides with alcohols amines or mercaptans. Alkaline reacting salts and cleansing agents specified are caustic alkalis, alkali metal or ammonium carbonates, alkali silicates and phosphates and lauryl amine. Aromatic amines specified are dimethyl- or dibutylaniline, xylidene, naplltliylarniilc and phenylene-diamine. Solvents specified are ethyl alcohol, glycol and glycerine. Inorganic salts specified are sodium sulphate, sodium chloride and ammonium chloride. According to examples: (1) a mixture of sodium meta-silicate, trisodium phosphate and dimethylamino-aceticacid - dodecylamide - chlormethylate. (CH3)3. NCl.CH2.CO.NH.(C12H25)' is used as a dilute aqueous solution to destroy mycoderma; (2) a mixture of caustic soda, sodium metasilicate, trisodium phosphate, and piperidinoacetic acid dodecyl amide chlor-benzylate is used in dilute aqueous solution as a disinfectant and cleansing agent. The amides employed may be prepared by reacting amides, produced from halogenated lower aliphatic acids and amines containing a lipophile residue, with tertiary amines, or by converting into quaternary compounds amides produced from amino-carboxylic acids and amines containing a lipophile residue. The Provisional Specification relates also to the use of compounds in which the hydrogen atom attached to the nitrogen atom of the amide group is replaced by an organic residue, states that solutions of the amides may be used without addition of other substances, and includes additional examples in which the active substances are respectively : (benzylmethyl-amino)- acetic acid dodecyl amide chlormethylate of the formula (CH3)2(C7H7) NCl.CH2.CO.NH.C12H25; compounds similar to the foregoing but with octyl, decyl, or tetradecyl residues in place of the dodecyl residue ; dimethyl-amino-acetic acid (benzyl-dodecylamide)-chlormethylate of the formula (CH3)3. NCl.CH2.CO.N(C7H7) (C12H25) ; (benzyl-methylamino) - acetic acid - (methyl - dodecylamide)- chlormethylate ; dimethyl amino phenyl-acetic acid dodecylamide chlormethylate of the formula (CH3)3.NCl.CH(C6H5).CO.NH.C12H25 and benzyl cyclohexyl-amino-acetic acid dodecylamide chlormethylate. Reference has been directed by the Comptroller to Specifications 462,967, 466,772, 467,244, 476,843, [all in Group IV], and 479,925.