Patent SG-11201408171S-A (SG)
Title: Fbxo3 inhibitors
Inventor: CHEN BEIBEI
IPC: C07D233/60
Filed: 2013-03-13
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/184202 A1 (51) International Patent Classification: C07D 213/36 (2006.01) C07D 295/135 (2006.01) C07D 277/28 (2006.01) C07D 333/20 (2006.01) C07D 307/52 (2006.01) C07D 233/60 (2006.01) C07D 231/10 (2006.01) C07D 239/26 (2006.01) C07D 471/04 (2006.01) C07D 471/10 (2006.01) C07D 413/12 (2006.01) A61K 31/137 (2006.01) A61K31/5375 (2006.01) A61P 3/10 (2006.01) A61P11/06 (2006.01) A61P19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07C15/12 (2006.01) C07C13/10 (2006.01) A61K31/402 (2006.01) A61K31/4418 (2006.01) A61K31/4155 (2006.01) A61K 31/427 (2006.01) A61K 31/381 (2006.01) A61K 31/341 (2006.01) A61K31/506 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/030995 13 March 2013 (13.03.2013) English English (30) Priority Data: 61/657,423 8 June 2012 (08.06.2012) US (71) Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 200 Gardner Steel Conference Center, Thackeray And O'hara Streets, Pittsburgh, PA 15260 (US). THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; Office Of General Counsel - PSG IV (024), 810 Vermont AvenuE N.W., Washington, DC 20420 (US). (72) Inventors: CHEN, Beibel; 175 Berryfield Ct., Wexford, PA 15090 (US). MALLAMPALLI, Rama, K.; 1401 N. Shevlin Ct., Sewickley, PA 15143 (US). (74) Agent: RUPERT, Wayne; Klarquist Sparkman, LLP, One World Trade Center, Suite 1600, 121 Sw Salmon Street, Portland, OR 97204 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: FBX03 INHIBITORS CJ o CJ •t 00 i-H o CJ o & (57) Abstract: The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.