Patent SG-11201903304Y-A (SG)
Title: IL15/IL15Ra HETERODIMERIC FC-FUSION PROTEINS
Inventor: BERNETT MATTHEW
IPC: C07K14/54
Filed: 2017-10-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 Organization 0 1110101011111 011101 0 011111111 011111111011111011111111111011111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/071919 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: 91016 (US). VARMA, Rajat; c/o Xencor, Inc., 111 West C07K 14/54 (2006.01) C07K 19/00 (2006.01) Lemon Avenue, Monrovia, CA 91016 (US). BONZON, C07K 14/715 (2006.01) Christine; c/o Xencor, Inc., 111 West Lemon Avenue, (21) Monrovia, CA 91016 (US). International Application Number: PCT/US2017/056829 (74) Agent: NG, Jennifer K. et al.; Morgan, Lewis & Bockius (22) International Filing Date: LLP, One Market, Spear Street Tower, San Francisco, CA 16 October 2017 (16.10.2017) 94105 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/408,655 14 October 2016 (14.10.2016) US DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/416,087 01 November 2016 (01.11.2016) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/443,465 06 January 2017 (06.01.2017) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/477,926 28 March 2017 (28.03.2017) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (71) Applicant: XENCOR, INC. [US/US]; 111 West Lemon SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, Avenue, Monrovia, CA 91016 (US). TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: BERNETT, Matthew; c/o Xencor, Inc., (84) Designated States (unless otherwise indicated, for every 111 West Lemon Avenue, Monrovia, CA 91016 (US). kind of regional protection available): ARIPO (BW, GH, RASHID, Rumana; c/o Xencor, Inc., 111 West Lemon Av- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = enue, Monrovia, CA 91016 (US). DESJARLAIS, John; c/ UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, o Xencor, Inc., 111 West Lemon Avenue, Monrovia, CA TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = = (54) Title: IL15/IL15Ra HETERODIMERIC FC-FUSION PROTEINS Figure 1 — = = = — 11.451113(CEW' = — s = = ammo ri gamma = = _ Agin (CD1.37.4 — = Il C:r 0.4$ :• ••• Il CT Il IN 0 --.... 11.-33Ra{sushi) 00 Il 0 (57) ei : The present disclosure is directed to several IL15/IL15Ra heterodimeric Fc fusion proteins. C [Continued on next page] WO 2018/071919 Al MIDEDIMOMOIDEIREEMOMMOHHOICHIMMIS EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))