Patent SG-11201809678V-A (SG)
Title: [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
Inventor: GOBBI LUCA
IPC: C07D487/04
Filed: 2017-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 MEM 0 11101 HOE 010 1111 1 0 0101101011M 010 1111 1111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/220517 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 487/04 (2006.01) A61P 11/00 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 31/519 (2006.01) A61P 33/00 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, A61P 29/00 (2006.01) A61P 35/00 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, A61P 25/00 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/EP2017/064994 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 20 June 2017 (20.06.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 16175924.6 23 June 2016 (23.06.2016) EP MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant (for all designated States except US): F. HOFF- KM, ML, MR, NE, SN, TD, TG). MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). Declarations under Rule 4.17: (71) Applicant (for US only): HOFFMANN-LA ROCHE — of inventorship (Rule 4.17(iv)) INC. [US/US]; Overlook at Great Notch, 150 Clove Road, Published: 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- — with international search report (Art. 21(3)) sey 07424 (US). — = = Inventors: GOBBI, Luca; c/o F. Hoffmann-La Roche (72) — AG, Grenzacherstrasse 124, 4070 Basel (CH). GRETHER, = Uwe; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). GUBA, Wolfgang; c/o F. Hoff- mann-La Roche AG, Grenzacherstrasse 124, 4070 Basel = _ (CH). KRETZ, Julian; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). MARTIN, Rain- er E.; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse = = 124, 4070 Basel (CH). WESTPHAL, Matthias; c/o Eidge- noessische Technische Hochschule Zuerich, Raemistrasse = = 101, 8092 Zuerich (CH). IJZERMAN, Adriaan Pieter; c/ o Leiden University, Rapenburg 70, 2311 EZ Leiden (NL). = = Agent: POMERANC, Didier; Grenzacherstrasse 124, 4070 Basel (CH). (74) = Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = Title: [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RE- (54) CEPTOR 1-1 ..11 1 (57) : The invention relates to a compound of formula (I) wherein R 1 to R 4 and N R— \ _ n are defined as in the description and in the claims. The compound of formula (I) can be ,N R 4 1-1 N used as a medicament. 1 1 in , , , 0 N N el N el (I) IN 1-1 © el n R 3 0