baber/WOPTO huggingface dataset:
Patent MY-171190-A (MY)
Title: Curable composition, cured product, and method for using curable composition
Inventor: MATSUI MASAMI
IPC: C08K5/544
Filed: 2013-03-22
Abstract: The present invention is: a curable composition comprising a component (A) and a component (B) in a mass ratio (component (A):component (B)) of 100:0.3 to 100:40, the component (A) being a silane compound copolymer that is represented by a formula ( a-1 ), and has a weight average molecular weight of 800 to 30,000, ... ~-1)  wherein R1 is a hydrogen atom, etc., X 0 is a halogen atom, etc., Dis a single bond, etc., R2 is a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, etc., Z is a hydroxyl group, etc., m and n are independently a positive integer, and o, p, q, and rare independently 0 or a positive integer, and the component (B) being a silane coupling agent that includes a nitrogen atom in its molecule. With the invention, it is possible to provide: a curable composition that produces a cured product that exhibits excellent heat resistance, excellent transparency, and high adhesion; a cured product obtained by curing the curable composition; and a method for using the curable composition as an optical device adhesive, etc.
Patent MY-174098-A (MY)
Title: Mechanically activated contingency release system and method
Inventor: NOFFKE RICHARD PAUL
Filed: 2012-05-02
Abstract: A release system comprises a torsional lock sleeve (202) disposed about a mandrel (204), and a collet prop (206) engaged with the mandrel. The torsional lock sleeve and the mandrel are configured to substantially prevent rotational movement of the torsional lock sleeve about the mandrel, and the torsional lock sleeve is configured to shift between a first position and a second position with respect to the mandrel. When the torsional lock sleeve is in the first position, the collet prop is retained in engagement with a collet (208) and the collet prop is retained in a torsionally locked engagement with the torsional lock sleeve. The collet prop is configured to longitudinally translate in response to a rotational movement when the torsional lock sleeve is disposed in the second position. A shifting assembly is configured to engage the torsional lock sleeve and shift the torsional lock sleeve from the first position to the second position.
Patent MY-186607-A (MY)
Title: Bacteriophage therapy
Inventor: DANGLAS PASCAL
IPC: A61K35/76
Filed: 2014-04-30
Abstract: The subject invention provides a pharmaceutical composition comprising: (i) at least one bacteriophage strain(s) capable of producing a lytic infection in an adherent- invasive Escherichia coli strain; and (ii) a pharmaceutically acceptable carrier; for the treatment of inflammatory bowel disease. The subject invention further provides a method of treating inflammatory bowel disease comprising administering to a subject in need thereof at least one bacteriophage strain capable of producing a lytic infection in an adherent-invasive Escherichia coli strain thereby treating the subject. The subject invention also provides new bacteriophage strains.
Patent MY-178208-A (MY)
Title: A screw conveyor for a centrifugal separator, especially a decanter centrifuge, and a centrifugal separator
Inventor: BENT MADSEN
Filed: 2013-09-12
Abstract: A screw conveyor for a centrifugal separator comprises a conveyor hub (19) carrying a helical conveyor flight (21) and providing a helical channel (22) between adjacent turns of helical conveyor flight (21 ). The screw conveyor has an up-stream end (7) and a down-stream end  (11).   At least two partition walls (41, 43) are arranged in a side-by-side relation to divide at least a radial part of a length of the helical channel (22) into three sub-channels (36, 37, 39) arranged in a side-by-side relation to cause a liquid flowing in the helical channel (22) to flow in an up-stream direction (35) towards the up-stream end (7) in an intermediate sub-channel (37) and in an opposite down-stream direction (34) towards the down-stream end (11) in two adjacent sub- channels (36, 39) on either side of the intermediate sub-channel (37).    FIG. 1
Patent MY-172796-A (MY)
Title: Nutritional compositions containing structured fat globules and uses thereof
Inventor: GONZALEZ JUAN M
IPC: A23L33/00
Filed: 2014-02-21
Abstract: The present disclosure relates to a lipid source for nutritional compositions, comprising an enriched lipid fraction which comprises structured fat globules. The enriched lipid fraction provides fat globules having a desired size and fatty acid composition and may be stabilized by components such as phospholipids, cholesterol, milk-fat globule membrane protein and combinations thereof. Additionally, the disclosure relates to methods of supporting lipid digestion in a pediatric subject by providing a nutritional composition comprising an enriched lipid fraction having structured fat globules that are more accessible to lipases. The chemical composition, size and structure of the fat globules may improve digestion. The disclosed nutritional compositions may provide additive and or/synergistic beneficial health effects.
Patent MY-176476-A (MY)
Title: A device for bone support with improved rotational stability
Inventor: HALDER SUBHASH CHANDRA
Filed: 2014-10-21
Abstract: A bone support fixating device (1) with a longitudinally slotted hip screw which permits operative compression of the fracture and holds this compression yet allows sliding as further compression of the fracture occurs under forces of weight bearing; comprising a hollow cylindrical shaft with a screw portion at its upper proximal end and four equally spaced longitudinal grooves (27) at its lower distal end (210), having three equally distant angled holes between the ends, through which three wires (42_a, 43_a, 44_a) can be inserted, the three 'elastic' proximally curved wires, welded, glued or crimped distally, can be inserted into the hip screw collectively called the 'tri-wire' (5); The proximal end has the wires curved outward, with all three wires (42_a, 43_a, 44_a) equally spaced; upon pushing the tri-wire (5) into the hip screw, the wires (42_a, 43_a, 44_a) goes through the angle holes in the hip screw and provides three projections (42, 43, 44) equally spaced; which improves the rotational stability of the proximal fracture fragment.     Most illustrative drawing: Figure 1
Patent MY-184863-A (MY)
Title: Polyurethane urea-containing compositions and optical articles and methods for preparing them
Inventor: BOJKOVA NINA V
IPC: C08G18/32
Filed: 2013-12-11
Abstract: A composition for the preparation of a transparent, non-elastomeric optical article is provided, the composition including: 1)	a polyisocyanate component containing one or more different polyisocyanates; and 2)	a component that is reactive with isocyanates, including: a)	optionally at least one polyol having a number average molecular weight greater than 500; b)	(i) at least one polyol and/or polythiol and (ii) at least one compound containing both amine and hydroxyl functional groups, wherein the c)	compound (ii) has a number average molecular weight less than 500; and optionally 3)	a urethanation catalyst. Multi-step and one-pot methods of preparing a cured, non-elastomeric polyurethane-containing optical article are also provided.
Patent MY-180575-A (MY)
Title: Cyclopropanamine compound and use thereof
Inventor: MATSUMOTO SHIGEMITSU
Filed: 2015-04-09
Abstract: The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis) , neurodegenerative diseases (e. g. , Alzheimer' s disease, Parkinson's disease, spinocerebellar degeneration (e.9., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula  (1)  wherein each symbol specification, or a is as defined in the present salt thereof.
Patent MY-178023-A (MY)
Title: Bottle having one or more internal projections
Inventor: LAIB DOUGLAS
Filed: 2015-05-27
Abstract: A bottle (20, 120, 220, 320, 3620, 3920, 4020, 4120, 4220) comprising a neck (28,128, 228, 328, 828, 928, 1028, 1128, 1228, 1228, 1428, 1528, 1628, 1728, 1828, 1928, 2020, 2128, 2228, 2328, 2428, 2528, 2628, 2728, 2828, 2928, 3028, 3128, 3228, 3328, 3628, 3928,4028, 4128, 4228) that includes a longitudinal axis extending therethrough, a neck finish (32, 132, 232, 332, 3632, 3932, 4032, 4132, 4232), and a radially-facing interior surface (29,3629, 3929, 4029, 4129, 4229). The neck also includes one or more internal projections (46,146, 246, 346, 846, 946, 1046, 1140, 1246, 1341, 1541, 1640, 1742, 1842, 1946, 2046, 2146,2341, 2446, 2540, 2646, 2740, 2840, 2941, 3041, 3140, 3246, 3646, 3946, 4046, 4146, 4246) projecting in a radially-inwardly direction from said interior surface and axially overlapping at least a portion of said neck finish.
Patent MY-182242-A (MY)
Title: Polybutene preparation method
Inventor: KIM MYEONG SEOK
Filed: 2015-08-21
Abstract: A method for preparing polybutene includes the steps of: supplying a C4 mixture to an isomerization reactor (10) in which (i) 1-butene is isomerized into 2-butene by a hydrogen isomerization reaction using an isomerization catalyst in an isomerization zone (12) of the isomerization reactor and (ii) iso-butene and 2- butene are separated by fractional distillation in a fractional distillation zone (14); supplying a C4 mixture containing 2-butene which is separated in the isomerization reactor to a skeletal isomerization reactor (20), in which a part of normal-butene is skeletal isomerized into iso-butene by a skeletal isomerization reaction using a skeletal isomerization catalyst, and the obtained skeletal isomerization mixture is supplied and recycled to the isomerization reactor; and supplying (i) a raw material containing the iso-butene of high concentration and which is separated from the isomerization reactor and (ii) a polymerization catalyst to a polybutene polymerization reactor (30) and thereby producing polybutene by a polymerization reaction. (Figure 1)
Patent MY-193533-A (MY)
Title: High-strength high-elongation tinned primary plate and double cold reduction method therefor
Inventor: LIAN FULIANG
IPC: C22C38/06
Filed: 2017-05-26
Abstract: A HIGH-STRENGTH HIGH-ELONGATION TINNED PRIMARY PLATE AND A DOUBLE COLD REDUCTION METHOD THEREFOR. THE TINNED PRIMARY PLATE COMPRISES THE FOLLOWING COMPONENTS BY WEIGHT FROM 0.065 TO 0.12% OF CARBON, FROM 0.2 TO 0.8% OF MANGANESE, FROM 0.003 TO 0.015% OF NITROGEN, THE REMAINDER BEING IRON AND THE INEVITABLE TRACE IMPURITIES. THE TINNED PRIMARY PLATE IS NECESSARILY SUBJECTED TO DOUBLE COLD REDUCTION AT A REDUCTION OF 5~13% AND A ROLLING TENSION OF 50~100 MPa. THE TINNED PRIMARY PLATE HAS A YIELD STRENGTH OF Rp?.?>520 MPa, AND PERCENTAGE ELONGATIONS IN ROLLING DIRECTION RD, 45? DIRECTION AND PERPENDICULAR DIRECTION TD, WHICH ARE ALL GREATER THAN OR EQUAL TO 10% AFTER BAKE-HARDENING.
Patent MY-186427-A (MY)
Title: Improved polyester/primer/metal composite film that is cohesive and impermeable to gas, method for the production thereof and the primer utilized in said method
Inventor: OUZINEB KELTOUM
IPC: C08J7/056
Filed: 2016-10-14
Abstract: The aim of the invention is to provide polyester/primer/metallic coating composite films having good adherence of the metallic coating in dry and humid conditions. Said films also form a good gas barrier: oxygen permeability less than or equal to 0.8 cc/m2/d; water vapour permeability less than or equal to 0.3 g/m2/d. To this end, the invention concerns a composite film comprising a polyester substrate, at least one coating adhering on at least one of the faces of the substrate and at least one layer of primer for cross-linked adhesion between the substrate and the coating. Said primer comprises at least one acrylic and/or methacrylic polymer P1, at least one acrylic and/or methacrylic polymer P2 different from P1, at least one cross-linking agent, and, preferably, at least one polyester that is soluble or dispersible in water: - P1 having a gel content TG1 > 70% by dry weight with respect to P1; - P2 having a gel content TG2 <TG1 and < 20% by dry weight, with respect to P2; - P1 having a surface-grafted free weak acid content > 0.8 in meq/g of polymer; -[P2] < 60% by weight on dry by weight in respect to P1 + P2. The method for producing said film, the adhering primer, and the articles obtained using said film, also form part of the present invention.
Patent MY-190500-A (MY)
Title: Zeolite separation membrane and production method therefor
Inventor: Satoshi IMASAKA
IPC: B01D69/12
Filed: 2017-02-17
Abstract: Provided are an all-silica zeolite separation membrane for separating carbon dioxide, etc., and not causing a decrease in the processing amount due to adsorption of water molecules, and a production method therefor. One aspect of the present invention is a zeolite separation membrane, in which the framework of a zeolite crystal structure formed on a porous support is all silica, characterized in that the zeolite crystal structure formed on the porous support is fluorine free. Another aspect of the present invention is a method for producing a zeolite separation membrane having a zeolite crystal structure on a porous support, characterized in that the method includes a step of producing a seed crystal, a step of applying the seed crystal onto the porous support, a step of producing a membrane synthesis raw material composition, and a step of immersing the porous support having the seed crystal applied thereon in the membrane synthesis raw material composition and performing hydrothermal synthesis, and the membrane synthesis raw material composition contains a silica source and an organic template and does not contain a fluorine compound.
Patent MY-192617-A (MY)
Title: Extract of plant powder, and water purifier
Inventor: FUJITA TAKANORI
IPC: C02F1/56
Filed: 2017-09-12
Abstract: Provided are an extract, which is a fractionated component 1 of a water extract of a plant powder, wherein the fractionated component 1 is a fractionated component having a fractionation molecular weight of 12,000 or greater, wherein an ethanol-undissolved component of the fractionated component 1 exhibits a peak attributable to carboxylic acid in a Fourier transform infrared spectroscopy (FT-IR) measurement and exhibits a peak attributable to cellulose in a gas chromatography mass spectrometry (GC-MS) measurement, and wherein an ethanol-dissolved component of the fractionated component 1 exhibits a peak attributable to carboxylic acid in the FT-IR measurement and exhibits a peak attributable to a plant protein in the GC-MS measurement, and a water-purifying agent containing the extract.  Fig.1
Patent MY-169242-A (MY)
Title: A colour mixing teaching aid
Inventor: MARIAM HANISA BINTI AHMAD SAIFUDDIN
IPC: G09B11/10
Filed: 2017-01-25
Abstract: The present invention relates to a colour mixing teaching aid (100), comprising a body (110); a motor (130) connected to a battery and a switch (120); a rotating shaft (152) functionally connected to the motor (130), defining the rotation of the rotating shaft (152) is activated by the motor (130); characterised by a rotating disc (150) coupled to the rotating shaft (152), allowing a minimum of two colour plates (160) attaching thereto by an attaching means; wherein the colour plate (160) are detachable from the rotating disc (150); a slot (140) allocated in the body (110), for accommodating unused colour plates (160).
Patent SG-10201809985T-A (SG)
Title: Methods and devices for nasopharyngeal carcinoma screening
Inventor: NG RAYMOND HIN WAI
Filed: 2014-10-03
Abstract: METHODS AND DEVICES FOR NASOPHARYNGEAL CARCINOMA SCREENING Methods and devices for nasopharyngeal carcinoma screening are disclosed. The method comprises providing a nasopharyngeal sample from a subject, isolating DNA from the sample, amplifying and detecting at least one EBV target sequence from the 5 DNA using real-time PCR, wherein a real time PCR cycle threshold number of less than or equal to 31.5 is indicative of the subject having nasopharyngeal carcinoma or a risk of developing nasopharyngeal carcinoma. The device for obtaining a brush biopsy sample comprises a longitudinal shaft having a first end and a second end, wherein at least two brush heads extend from the second end of the shaft. 10 FIGURE 4
Patent SG-11201804467V-A (SG)
Title: Communication control device, toll collection system, communication control method, and program
Inventor: IEUJI Saku
IPC: G07B15/00
Filed: 2015-11-30
Abstract: A communication control device (3) includes: an identifier extraction unit (30) which is configured to extract an identifier for identifying an on-board unit (A1) from an on-board unit transmission signal (D2) obtained by receiving, through a toll collection antenna (20), radio waves transmitted by the on-board unit (A1); a position measurement 5 unit (31) which is configured to measure the position of an on-board unit (A1) which has transmitted radio waves on the basis of a position measurement signal (D4) obtained by receiving, through predetermined position measurement antennas (22A and 22B), radio waves transmitted by the on-board unit (A1); and an identifier registration unit (322) which is configured to register the identifier included in the on-board unit transmission 10 signal (D2) correlating with the position measurement signal (D4) as a permitted identifier when the position of the on-board unit (A1), measured on the basis of the position measurement signal (D4), is present within a prescribed defined communication region. 15
Patent SG-11201907234T-A (SG)
Title: Power supply circuits, wearable devices and methods for providing power supply to a wearable device
Inventor: LIEN JIAN YAO
IPC: G06F1/26
Filed: 2017-02-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT 0111111010 0111 °nolo OH Em mom Imo oimIE (10) International Publication Number WO 2018/151665 Al (51) International Patent Classification: GO6F 1/32 (2006.01) GO6F 1/16 (2006.01) GO6F 1/26 (2006.01) (21) International Application Number: PCT/SG2017/050068 (22) International Filing Date: 16 February 2017 (16.02.2017) (25) Filing Language: English (26) Publication Language: English (71) Applicant: RAZER (ASIA-PACIFIC) PTE. LTD. [SG/SG]; 514 Chai Chee Lane, #07-05, Singapore 469029 (SG). (72) Inventors: LIEN, Jian Yao; c/o Razer (Asia-Pacific) Pte. Ltd., 514 Chai Chee Lane, #07-05, Singapore 469029 (SG). CHAN, Chee Oei; c/o Razer (Asia-Pacific) Pte. Ltd., 514 Chai Chee Lane, #07-05, Singapore 469029 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — (54) Title: POWER SUPPLY CIRCUITS, WEARABLE DEVICES AND METHODS FOR PROVIDING POWER SUPPLY TO A WEARABLE DEVICE (57) : According to various embodiments, there is provided a power supply circuit including: a power switch configured to activate 600 one of a primary power source or a secondary power source based on a state of charge of the secondary power source; wherein the prima- ry power source is configured to, when activated, power a low pow- er component; and wherein the secondary power source is configured to, when activated, power the low power component and a high power component; and a clock switch configured to provide a clock signal to the high power component based on the state of charge of the secondary power source. W O 20 18/ 15 1665 Al 606 Power switch 660 Clock switch 614 FIG. 6
Patent SG-11201909636Q-A (SG)
Title: Device for generating hydrogen gas
Inventor: CHIA CHIN YANG
IPC: C01B3/06
Filed: 2017-04-22
Abstract: Figure 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT o mono °nolo om mo Ho Ho Em Inv ois (10) International Publication Number WO 2018/194442 Al (51) International Patent Classification: C01B 3/06 (2006.01) (21) International Application Number: PCT/MY2017/050019 (22) International Filing Date: 22 April 2017 (22.04.2017) (25) Filing Language: English (26) Publication Language: English (71) Applicant: GALAXY FCT SDN. BHD. [MY/ ]; No. 3, 1st Floor, Jalan USJ 21/11, Petaling Jaya, 47630 (MY). (72) Inventors: CHIA, Chin Yang; 3, First Floor, Jalan USJ 21/11, Subang Jaya, 46300 (MY). YEE, Yoke Keen; 16, Jalan SS 20/26, Damansara Kim, Petaling Jaya, 47400 (MY). NG, Albert, Kok Foo; 3, First Floor, Jalan USJ 21/11, Subang Jaya, 46300 (MY). (74) Agent: TOONG, Jo-Han; A-5-10 Empire Tower, SS16/1, Subang Jaya, 47500 (MY). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: DEVICE FOR GENERATING HYDROGEN GAS [Fig. 2] co 1-1 (57) : A device for generating hydrogen gas having two or more storages, each storage storing a reactant or mix of reactants, \" and each storage coupled to a means of injecting the stored reactant or mix of reactants into a reaction chamber in a controlled manner 0 and at an optimum rate, so that a chemical reaction occurs in the reaction chamber that produces hydrogen gas efficiently.
Patent DK-164170-B (DK)
Inventor: WISSMANN HANS
IPC: C07F9/40
Filed: 1987-01-08
Abstract: The invention relates to new thyronine derivatives of the formula <IMAGE>  (I)  in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R1 and R2 are identical or different and denote iodine or hydrogen, and R3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.