baber/WOPTO huggingface dataset:
Patent EC-SP066740-A (EC)
Title: ß-HIDROXI ÉSTERES HETEROAROMÁTICOS ÓPTIMAMENTE ACTIVOS, PROCESOS PARA SU PREPARACIÓN A PARTIR DE ß-CETO ÉSTERES Y PROCESOS PARA LA PREPARACIÓN DE DICHOS ß-CETO ÉSTERES
Inventor: KLAR ULRICH
IPC: C12P17/12
Filed: 2006-07-31
Abstract: La presente invención se refiere a ésteres ß-hidroxi heteroaromáticos ópticamente activos de fórmula (I) de utilidad en la síntesis de derivados de epotilona, beta-ceto ésteres de fórmula (IV) utilizados para producir estos intermediarios por hidrogenación asimétrica con un catalizador metálico quiral o una reducción microbiológica o enzimática, así como los procesos para su producción (I), en donde: A es un residuo heteroaromático bicíclico de fórmula (A), en donde el término "heteroaromático" se refiere a un anillo heteroaromático de 5 ó 6 miembros que contiene hasta 2 heteroátomos seleccionados entre oxígeno, nitrógeno o azufre, opcionalmente sustituido con uno o dos sustituyentes seleccionados entre alquilo, hidroxialquilo opcionalmente protegido, halo-alquilo, halógeno o CN, y R es una cadena de alquilo de cadena lineal o ramificada, opcionalmente saturada, que contiene opcionalmente 1-3 átomos de oxígeno; un residuo fenilo; ciclohexilo; o bencilo (IV).
Patent EC-SP099086-A (EC)
Title: Comprimido masticable que contiene fenilefrina
Inventor: FUBARA JOSEPHINE
IPC: A61K9/68
Filed: 2009-01-23
Abstract: Se suministra una composición farmacéutica masticable que comprende fenilefrina, endulzante artificial, y una matriz sustancialmente libre de aldehído. La composición tiene estabilidad de fenilefrina adecuada para un producto comercial típico con dos años de vida de almacenamiento. Un método de elaboración de la composición y también se suministra un método de uso.
Patent EC-SP961893-A (EC)
Title: (metil sulfonil) fenil -2-(5h)- furanomas como inhibidores de cox - 2''
Inventor: BLACK CAMERON
IPC: C07F9/80
Filed: 1996-10-10
Abstract: La invención abarca el compuesto novedoso de fórmula I, útil en el tratamiento de enfermedades mediadas por ciclooxigenasa-2 (gráfico), La invención también abarca ciertas formulaciones farmacéuticas para el tratamiento de enfermedades mediadas por ciclooxigenasa-2 que comprende compuesto de la fórmula I
Patent EC-SP993305-A (EC)
Title: Uso de derivados del acido 4- bialrilbutirico y 5-biarilpentanoico sustituidos como inhibidores de la metaloproteasa de matriz para el tratamiento de enfermedades respiratorias
Inventor: SCHLEMMER KARL HEINZ
IPC: A61K31/19
Filed: 1999-12-29
Abstract: Nuevos derivados de los ácidos 4-biarilbutírico y 5-birarilpentanoico, uso de los derivados de los ácidos 4-biarilbutírico y 5-birarilpentanoico sustituidos como inhibidores de la metaloproteasa de la matriz para la prevención y tratamiento de enfermedades respiratorias, composiciones farmacéuticas que los contienen y un procedimiento para su uso. Los compuestos de la invención tienen la fórmula general: (T) * A-B-D-E-CO2H en la que A ers un anillo arilo o heteroarilo; B es un anillo arilo o heteroarilo o un enlace; cada T es un grupo sustituyente; X es 0,1 ó 2 ; el grupo D representa (gráfico), el grupo E representa una cadena de dos o tres carbonos que lleva de uno a tres grupos sustituyentes que son independientes o que están implicados en la formación de un anillo, mostrándose las posibles estructuras en el texto y en las reinvindicaciones; y cada uno de los sustituyentes sobre E es un sustituyente independiente; incluyendo las sales farmacéuticamente aceptables de los mismos.
Patent EE-9800446-A (EE)
Inventor: ARI PIRINEN
IPC: E05B47/00
Filed: 1998-12-15
Abstract: A lock casing (1) for installation in a door or the like, comprising a case-like lock housing (5) provided with a front plate (6) and including a bolt (7), follower means (12) turnable about an operating axis (A) at least from one side of the door by means of a key-operated locking mechanism, and force transmitting means (13,15,16,18,21), by which the follower means can be arranged in force transmitting connection with the bolt (7). The follower means (12) is part of a separate follower unit (2) which is arranged to be separately fastened to the lock casing (1) so that the distance of the operating axis (A) from the front plate (6) is adjustable. <IMAGE>
Patent GB-1026847-A (GB)
IPC: D06M13/11
Abstract: 1, 026, 847. Treating cellulosic materials. DEERING MILLIKEN RESEARCH CORPORATION. Feb. 8, 1963 [Feb. 15, 1962], No. 5257/63. Heading D1P. Wet configurational memory is imparted to cellulosic materials by impregnating them with 0.5%-130% moisture and 0. 75%-15% of strong base catalyst calculated as NaoH both calculated on the weight of the dry cellulosic material and then treating them with gaseous epichlorohydrin in a closed system while in the selected configuration for at least 5 seconds until at least 0. 75% of strong base catalyst calculated as NaoH and as the weight of the dry cellulosic material has been consumed. The strong base catalyst which is defined as having a pH of at least 10 as a 1% by weight aqueous solution and may be sodium or potassium hydroside, trimethyl phenyl ammonium hydroxide or an alkali metal sulphide or silicate, may be applied to the cellulosic material as an aqueous solution which serves to moisten the fabric by padding, applicator roll, print roll or spraying. When the cross-linking with the epichlorohydrin has proceeded to the desired extent the material may be heated at a temperature above the boiling point of the epichlorohydrin by means of steam heated dry cams or by radiant heat until substantially all of the epichlorohydrin is removed and then washed. A bulked effect is imparted to yarns cross -linked in a crumpled position and wrinkle resistance is imparted to fabrics cross-linked in a smooth state. If the strong base catalyst is applied unevenly a plisse effect is imparted to fabrics and a woollike effect to fibres. The cellulosic material may have been treated with a urea formaldehyde, melamine formaldehyde, cyclic ethylene urea, dihydroxy cyclic ethylene urea or triazone resin prior to treatment with the strong base catalyst and epichlorohydrin. Fibres, yarns, threads or knitted, non- woven or woven fabrics comprising natural cellulose, e.g. cotton, linen, jute or flax, regenerated cellulose, e.g. viscose rayon and polynosic rayons, or cellulose derivatives containing at least 1.8 free hydroxy groups per anhydroglucose unit, e.g. cellulose acetate, propionate, butyrate, benzoate, sulphate, phosphate, aryl or alkyl sulphate and methyl, ethyl, hydroxyethyl, carboxymethyl or carboxyethyl cellulose fibres, alone or in admixture with polyester, nylon or polyacrylic fibres may be treated.
Patent GB-1050177-A (GB)
IPC: C07D213/80
Abstract: 1,050,177. Basic nicotinic acid esters. KREWEL-LEUFFEN G.m.b.H. Aug. 4, 1964 [July 18, 1963], No. 30558/64. Heading C2C. Basic nicotinic acid esters of the general formula where R 1  and R 2  are alkyl, aralkyl, or aryl residues and B is a dialkylamino residue or a saturated N-heterocyclic ring attached by the nitrogen atom are made by the reaction of nicotinic acid chloride with the corresponding 1,3-amino-alcohol, or the alkali metal, alkoxide thereof, in an inert solvent or in a medium of water and a water-immiscible solvent, preferably in the presence of alkalis or tertiary organic bases. The preferred R 1 , R 2  groupings are methyl-propyl, ethyl-ethyl, ethyl-benzyl and ethyl-phenyl, and B is preferably dimethyl or diethyl amino, piperidino or pyrrolidino. The examples describe the syntheses of the compounds wherein R 1 , R 2  and B are as follows: Et, Et, -NEt 2 ; Ph, Et, piperidino; Et, Et, pyrrolidino; Ph, Et, pyrollidino. The compounds are stated to have cardio-vascular and neuro-pharmacological action.
Patent GB-1050197-A (GB)
IPC: C08J9/14
Abstract: 1,050,197. Extruding ultra microcellular sheets. E. I. DU PONT DE NEMOURS & CO. Nov. 19, 1964 [Nov. 27, 1963], No. 47232/64. Heading B5A. [Also in Division C3] Ultramicrocellular sheets having collapsed cells are prepared by extrusion of a solution in an " activating liquid " of a crystalline synthetic organic polymer to form a tube which is then stretched laterally by the pressure of confined gas as well as longitudinally to collapse the cells. The confined gas may be the vapour of the activating liquid. In the Figure (not shown), the polymer solution at a pressure above atmospheric and temperature above the normal boiling point of the activating liquid is extruded as a tube 12 from orifice 10 of die 11 and stretched longitudinally by pinch rolls 14 and 15 from which the tube passes as a double sheet 16. Activating liquid diffuses from the cells into the interior of 12 to inflate the bag thereby providing lateral stretch. The pressure of the vapour is held constant by venting through valve 18 and line 17. The sheets may be further processed, e.g. by annealing. Specified polymers are linear polymers of ethylene and propylene, crystallizable copolymers and graft copolymers of ethylene and propylene with other monomers such as 1-olefins of up to 10 C atoms, poly-(3-methylbutene), poly- (4-methylpentene) and isotactic polystyrene.
Patent GB-1051416-A (GB)
IPC: B65D51/28
Abstract: 1,051,416. Container closures. SOC. ANON. LES FERMIERS REUNIS DES FLANDRES. Feb. 18, 1964 [Sept. 26, 1963], No. 6680/64. Heading B8T. A closure 3 of sheet material for a container 1 has a projection 6 extending from the plane of a rim 4 which may be conical, hemispherical or ellipsoidal and which presses into the surface of the substance 2 within the container, so that only a small volume of air is enclosed under the closure in the annular space 5. When the closure is removed additional contents may be added without overflowing.
Patent GB-1084261-A (GB)
IPC: B60S5/06
Abstract: 1,084,261. Masted lift trucks; roller conveyers. LANSING BAGNALL Ltd. June 11, 1965 [June 30, 1964], No. 27047/64. Headings B8A and B8H. A pair of brackets 19 is detachably mounted on the back plate 14 of the lifting carriage of a battery-driven lift truck and is provided with shackles 26 for attachment to the battery box 16 whereby the batteries may be raised from the battery support 17. A cable 30 connects the batteries to the control circuit during lifting of the battery box. Having raised the battery-box to the position shown, pivoted extensions (39) of rollerways (35) on a-trolley (31), Fig. 3 (not shown), are inserted beneath the box 16 which is then lowered on to the rollerways. The extensions (39) are raised and locked in the raised position, Figs. 5, 7 (not shown), and the batteries are removed to a charging station. In a modification. Fig. 8 (not shown), the trolley (31) is replaced by a pair of trolleys (60) provided with rollers (62) whereby the battery box may be wheeled on to the platform (64) of a charging station. Alternatively, the trolleys (60) may be inverted to act as rollerways.
Patent GB-1225247-A (GB)
IPC: B41M1/12
Filed: 1967-07-05
Abstract: 1,225,247. Printing processes; stencilling. DUNLOP CO. Ltd. 3 July, 1968 [5 July, 1967], No. 30857/67. Heading B6C. A porous sheet material is printed with an ink such that the ink penetrates the material. It may diffuse due to capillary action or be blown or sucked through the material. A design may be imparted by sucking ink through a stencil superposed upon the material which may be foamed polyurethane or P.V.C. In the apparatus of Fig. 1, a porous sheet 12 is placed over a perforated metal plate 11 and a stencil is located on the sheet. Ink 14 is drawn through the stencil and sheet by the application of a vacuum box 10. The apparatus of Fig. 2, on the other hand, is used for printing on comminuted material 17 fed from a hopper 16 on to an endless belt 19 on which the material is transformed into a sintered porous sheet by dielectric heating means 24. The sheet is then passed between two vacuum pumps 25 and two rotating printing rollers 26 the pumps 25 sucking the ink from the rollers 26 through the sheet material. The printed sheet is subsequently provided with a backing material 28 in a continuous press machine 31 comprising heated rollers 32, 33, 34, 35, connected by appropriate belts 36, 37.
Patent GB-1225923-A (GB)
IPC: G01D11/28
Filed: 1969-08-20
Abstract: 1,225,923. Indicating apparatus. KIENZLE APPARATE G.m.b.H. Aug. 20, 1969 [Aug. 30, 1968], No.41558/69. Heading G1V. A front cover 14 for a housing 4 accommodating a non-transparent dial 8 arranged between the cover 14 and a light source 9, is made of transparent material and fixed to the casing 4 by a snap connection and has an annular surface, provided with a reflective coating, formed on the inside and inclined with respect to the dial 8. The cover 14 may be made of elastically deformable plastics material with an annular protrusion 16 engaging a groove 15 round the housing 4 and retained by three lug portions 17 snapped into incisions 18 while compressing a packing ring 20 into the groove 15. Light from the lamp 9 passes through the annular gap 21 for reflection from the surface 22 to the dial 8. A rib 23 serves as a screen to prevent direct emission of light to outside. Deflective coatings round the entire annular chamber between the rib 23 and portion 19 increase the light yield and these coatings or coloured underlayers give an ornamental impression from outside.
Patent GB-1232281-A (GB)
IPC: F16L33/22
Filed: 1968-05-25
Abstract: 1,232,281. Hose couplings. CO-OPERATIVE INDUSTRIES Inc. 25 Aug., 1969 [25 May, 1968], No. 25121/68. Heading F2G. A thin walled hose 9 e.g. for electric wiring is forced over a sleeve 8 and returned in a counterbore in the sleeve which is then slid over a spigot portion of an end fitting and held in position by a bead 11 deformed diving or after attachment. The sleeve 8 has a tapered outer surface at its inner end to assist entry into the hose 9. The bead 11 is either deformed outwardly by a mandrel after attachment of the sleeve 8 and hose 9, or the spigot portion has axial slots creating spring fingers which deform inwardly during attachment and then spring out to lock the sleeve.
Patent GB-1250140-A (GB)
IPC: A45D4/16
Filed: 1970-07-07
Abstract: 1,250,140. Heated hair-setting devices. SCOVILL MFG CO. July 7, 1970 [Aug. 11, 1969], No. 32913/70. Heading A4V. A device for setting hair by the application of heat comprises a mass of ferromagnetic ferrous alloy 66 and an electric heating element 70 having a pair of spaced contacts 72. The device is in the form of a roller 60 and the ferrous alloy 66 is in the form of a tubular core. An insulating layer 68 is disposed between the core and the heating element 70 which is surrounded by a further insulating layer 78. The device has an outer tubular plastics casing 62, having outwardly extending knobs and which is crimped over at its ends to hold in insulating discs 64. Each end of the heating element is connected to a head 74 of a contact pin 72 which extends through the disc 64. Alternatively a roller 60<SP>1</SP>, Figs.8 and 9 (not shown), may comprise a tubular core of anodized aluminium (86) and a tubular member (92) of ferrous alloy; or Fig. 10 (not shown), a roller 60<SP>11</SP> may comprise a plug (104) of aluminium, telescopically disposed over which is a cup (108) of ferrous alloy. The rollers may be pre-heated in apparatus comprising a housing having a pair of spaced contacts, connectable to an electrical supply, and a magnet positioned to hold a hair setting device with the contacts thereon in electrical contact with the contacts in the housing until a temperature approaching the curie temperature of the ferrous alloy is attained.
Patent GB-1251786-A (GB)
IPC: H05K13/00
Filed: 1970-03-04
Abstract: 1,251,786. Reparing cables; prizing tools. HEPWORTH ELECTRICAL DEVELOPMENTS Ltd. 4 March, 1970, No. 10271/70. Heading B4C. [Also in Division H2] A hand tool for separating the strands of a cable comprises a wedge 1 having T-shaped cross-section, an intermediate section 3 of rectangular cross-section, and a hook 2. The tool is made of strong insulating material e.g. a plastics material. The conductors are separated initially by the wedge, then the hook is inserted and the wedge used as a lever handle to prise the conductors farther apart, concave surface 4 acting as fulcrum.
Patent GB-1251846-A (GB)
IPC: C08G63/685
Filed: 1969-03-24
Abstract: 1,251,846. Polyesters from tris(2-hydroxyalkyl)isocyanate homopolymers. ALLIED CHEMICAL CORP. 24 March, 1969 [25 March, 1968; 18 Feb., 1969], No. 15404/69. Headings C3P and C3R. The invention comprises polyesters of a polycarboxylic acid and a polyol comprising a homopolymer of a tris(2-hydroxylalkyl)isocyanurate wherein each alkyl group contains at least two carbon atoms. The preferred isocyanurate is tris(2-hydroxyethyl)isocyanurate and the homopolymer is one which has been made by dissolving the isocyanurate and an acidic etherification catalyst in solvent water and heating the mixture at 150-250‹ C. and terminating the reaction before more than 0.75 mol water of condensation per mol of isocyanurate has been removed. The homopolymer may be partially replaced by another polyol, especially glycols of the formula H(OR) n OH where R is alkylene and n is 1-10 when the acid is partially esterified by the homopolymer first. Polycarboxylic acids specified are the phthalic acids; trimellitic, fumaric, succinic adipic, sebacic azelaic, maleic, tetrahydrophthalic, acrylic, substituted acrylic, itaconic, endo-bis-5-norbornene-2,3-dicarboxylic and methyl bicyclo(2,2,1)-heptene-2,3-dicarboxylic acids. Terephthalic acid is preferred. The polyesters may be oil-modified. In Example III a polyester according to the invention, is modified with coconut oil, to produce a modified resin which is used to make coating compositions in admixture with (1) butylated melamine -formaldehyde resin and (2) a phenolicformaldehyde resin.  The polyesters may be modified by incorporating into them, a di- or polyisocyanate which is initially blocked, by reaction at 650‹ to 800‹ C., to produce a polyurethane copolymer. The polyesters may also be modified by reaction with a carboxyl compound containing a five membered imide ring, to produce a polyester-imide copolymer. In Example IV, the imide used, is one obtained by reacting trimellitic anhydride with 4,41-diaminodiphenyl. methane.  When the polyesters of the invention contain unsaturation derived from an unsaturated acid, they may be cross-linked with an unsaturated monomer. In Example V such a polyester containing unsaturation derived from maleic acid, is cross-linked with 30 parts styrene to 70 parts resin, with a benzoyl peroxide initiator.
Patent GB-1252425-A (GB)
IPC: A01K89/08
Filed: 1968-08-21
Abstract: 1,252,425. Fishing rod and reel. NESS POINT INVESTMENTS Ltd. 15 Aug., 1969 [21 Aug., 1968], No. 40058/68. Heading A1A. A combined fishing reel and rod comprises a hollow tube 1 containing a shaft 2 connected to a line spool 3. The line is cast with spool 3 stationary and the line is retained by member 12 and loop 13 until the rod points in the direction of casting. For winding in, the line is passed through guide 4, and the spool which reciprocates is wound by handle 7 via shaft 2. Fig. 2 shows the winding and reciprocating mechanism. Bevel gear 8 connected to handle 7 via a variable drag means 17, 19 acts on either gear 15 or 9. A slide brings either gear 15 or 9 into engagement with gear 8, thus constituting a reversing mechanism. Gears 15 and 9 are slidably engaged shaft 2. The shaft and spool are reciprocated by eccentric pin 14 on bevel gear 8, sliding in slot 11 in member 10 which is attached to the shaft. The spool may be removed and remounted on its reverse side. This combined with the reverse winding mechanism removes line twist. (For Figures see next page)
Patent GB-1265741-A (GB)
IPC: F22B29/06
Filed: 1969-04-21
Abstract: 1,265,741. Once-through vapour generators. FOSTER WHEELER CORP. 21 April, 1969 [1 May, 1968], No. 20317/69. Heading F4A. An all-welded furnace construction for a oncethrough vapour generator comprises a rectangular furnace enclosure including two oppositely facing walls and side walls therebetween; each wall comprising a number of substantially parallel upright finned tubes welded together to define each wall including the lower parts of the walls; headers connected to the tubes so that the tubes are divided into a number of flow passes connected in series; the headers and their connections to the tubes being arranged so that the tubes adjacent to and on either side of the enclosure corners and defining each corner are of the same flow pass. The flow from the economizer is passed equally to two vertical headers 26, 26<SP>1</SP>, Fig. 1, each feeding the tubes of one half of a vertical division wall 24 (pass A). From the division wall, the flow is taken via a downcomer to a single header 28 and thence through the central tubes 22a of the flat floor 22, these tubes being bent upward to form the central tubes 14a of the front wall 14 (pass 1). From the tubes 14a, the flow is taken to inlet headers 30, 32, 34, 36, 38, 40 and thence through pass 2, comprising the entire side walls 18, 20, the side portions 16b and 16c of the rear wall 16, and the side portions 22b and 22c of the floor 22, the side portions 22b and 22c being bent upwardly to form the side portions 14b and 14c of the front wall. Finally, the flow passes to header 42 to flow through the central portion 16a (pass 3) of the rear wall 16. Thus, the three sides of each of the four bottom corners of the furnace enclosure are formed by tubes of the same pass (pass 2), whereby temperature differences producing thermal stresses in the welded connection between these tubes are avoided. As shown in Fig. 2, the tubes of each pass are welded together through fins. Where the tubes of pass 1 of the floor 22 pass through pass 3 of the rear wall 16 to join the header 28, they are bent as shown so that each group of four tubes is aligned in a vertical plane. The resultant gap in the floor is bridged by a seal plate 50 welded to the tubes. In a modification, the flat floor is replaced by a hopper bottom. For this purpose, the tubes which would have constituted a flat floor are bent downwardly to form one side of the hopper, while the other side of the hopper is formed by a continuation of the rear wall.
Patent GB-1301452-A (GB)
IPC: C07C59/64
Filed: 1970-01-20
Abstract: 1301452 Preparation of methoxynaphthylpropionic acid SYNTEX CORP 20 Jan 1970 [30 Sept 1969] 31642/72 Divided out of 1300591 Heading C2C 2 - (6 - Methoxy - 2 - naphthyl) propionic acid is prepared by heating a compound I in which R 1 , R 2  and R 4  are H, alkyl, alkenyl, phenyl or substituted phenyl and R 3  is as R 1  or is hydrocarbon acyl at 200-400‹C. and optionally resolving a fl-mixture thus formed. t - Butyl 2 - (6 - methoxy - 2 - naphthyl) propionate is prepared by reacting 2-(6-methoxy-2- naphthyl) acetic acid with t-butanol to give t-butyl 2-(6-methoxy-2-naphthyl) acetate, followed by methylation. Pharmaceutical compositions comprising 2-(6- methoxy-2-naphthyl)-propionic acid, when prepared as above, together with an excipient, are used in treating inflammation, pain and pyrexia.
Patent GB-1302362-A (GB)
IPC: G09F3/18
Filed: 1968-10-08
Abstract: 1302362 Vehicle licence holders T W CROFT 2 Jan 1970 [8 Oct 1968] 47736/68 Heading B8F A licence holder comprises a main plate 1 including mechanical holding means 2 for holding the licence, in combination with an element of wedge-shaped cross-section forming part of or attachable to the main plate and shaped so as to be retained between a resilient windscreen moulding 8 and the glass therein to fix the licence in a desired position. In Figs. 3, 4 the element is separate from the main plate 1 and provides with the windscreen a slot 13 to receive a tongue 6 projecting from the main plate. This element comprises a pair of tapered legs 11 interconnected by a bridge piece 12, the legs 11 having transverse grooves 7 to assist in retention of the element by the moulding 8. In a modification (Figs. 1, 2 not shown), the wedge-shaped element is integral with the main plate and comprises a tongue folded back on itself.