Patent SG-11201903917W-A (SG)
Title: Inhibitors of gangliosides metabolism for the treatment of motor neuron diseases
Inventor: DARIOS FRÉDÉRIC
IPC: A61K45/06
Filed: 2017-11-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/083223 Al 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61K 45/06 (2006.01) A61P 25/10 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 31/445 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/EP2017/078156 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 03 November 2017 (03.11.2017) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (25) Filing Language: English (26) Publication Language: English Published: — with international search report (Art. 21(3)) (30) Priority Data: — before the expiration of the time limit for amending the 16197362.3 04 November 2016 (04.11.2016) EP claims and to be republished in the event of receipt of (71) Applicants: ICM (INSTITUT DU CERVEAU ET amendments (Rule 48.2(h)) — DE LA MOELLE EPINIERE) [FR/FR]; Hopital Pitie with sequence listing part of description (Rule 5.2(a)) Salpetriere, 47/83 boulevard de l'Hopital, 75013 Paris (FR). UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC) [FR/FR]; 4 place Jussieu, 75005 Paris (FR). CENTRE NATIONAL DE LA RECHERCHE SCIEN- _ TIFIQUE [FR/FR]; 3 me Michel-Ange, 75016 Paris (FR). INSERM (INSTITUT NATIONAL DE LA SAN- — TE ET DE LA RECHERCHE MEDICALE) [FR/FR]; _ 101 rue de Tolbiac, 75654 Paris Cedex 13 (FR). APHP = (ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS) [FR/FR]; 3 avenue Victoria, 75001 Paris (FR). ECOLE PRATIQUE DES HAUTES ETUDES [FR/FR]; Les Pa- tios Saint Jacques, 4-14 me Ferrus, 75014 Paris (FR). Inventors: DARIOS, Frederic; 22 me Esther, 92160 = (72) Antony (FR). STEVANIN, Giovanni; 19 avenue Vic- tor Hugo, 93270 Sevran (FR). MOCHEL, Fanny; 55 me Georges Lardennois, 75019 Paris (FR). BRANCHU, Julien; 75 me Vauvenargues, 75018 Paris (FR). BOUTRY, Maxime; 44 me Coriolis, 75012 Paris (FR). _ = = Agent: ICOSA; 83 avenue Denfert-Rochereau, 75014 Paris (74) (FR). = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = — CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = — 1-1 N el (84) Designated States (unless otherwise indicated, for every N en GC kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 0 --.... 00 1-1 (54) Title: INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES 0 ei (57) : The present invention relates to inhibitors of gangliosides metabolism for treating motor neuron diseases, in particular C hereditary spastic paraplegias.