baber/WOPTO huggingface dataset:
Patent AU-2019222795-A1 (AU)
Title: Translocation and mutant ROS kinase in human non-small cell lung carcinoma
Inventor: GU TING-LEI
IPC: C07K14/00
Filed: 2019-08-26
Abstract: TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON SMALL CELL LUNG CARCINOMA In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of the new fusion protein enables new methods for determining the presence of these mutant ROS kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.
Patent AU-2019222816-A1 (AU)
Title: A method of diagnosing neoplasms - II
Inventor: YOUNG GRAEME P
IPC: C12Q1/68
Filed: 2019-08-27
Abstract: Abstract The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the DNA or the RNA or protein expression profile of one or more nucleic acid molecule markers.
Patent AU-2019233521-A1 (AU)
Title: Prefabricated floor element, structure comprising prefabricated floor elements and installation for obtaining the prefabricated floor element
Inventor: SANABRA LOEWE MARC
IPC: B28B1/08
Filed: 2019-03-12
Abstract: Prefabricated floor element (1) having an elongated shape wherein a longitudinal direction (X), a transversal direction (Y), a height direction (Z), two end faces (11) which delimitate the element (1) in the longitudinal direction (X), two lateral faces (12) which delimitate the element (1) in the transversal direction (Y), a lower face (13) and an upper planar face (14) that delimitate the element (1) in the height direction (Z) are defined, which comprises transversal continuous upper grooves (15) on the upper planar face (14) or lateral grooves (26) on the lateral faces (24), the lateral grooves (26) extending from the lower tab (TS) to the upper planar face (24). The invention also relates to a structure comprising such prefabricated floor element (1)and further comprising a linear supporting element (LS) which supports one end of the prefabricated floor element (1)such that in the linear supporting element (LS) a supporting surface (S1) is defined and a moment resisting system (MS) arranged on the linear supporting element (LS) and facing an end face (11) of the prefabricated floor element (1)and an upper concrete layer (LC) poured on top of the element (1) or in the shear key (SK) defined between two adjacent floor elements. The invention also relates to an installation for manufacturing the floor elements (1, 2).
Patent AU-2019236196-A1 (AU)
Title: YAP1 inhibitors that target the interaction of YAP1 with Oct4
Inventor: CHELLAPAN SRIKUMAR
IPC: C07D401/06
Filed: 2019-03-14
Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
Patent AU-2019236636-A1 (AU)
Title: Continuous delivery
Inventor: CARTWRIGHT HENRY FREDERICK
IPC: G06Q10/06
Filed: 2019-09-24
Abstract: Implementations include determining a set of routes for delivery of assets within a delivery network based on realized and forecasted demand for a period, during at least partial execution of the set of routes, receiving real-time data representative of delivery of assets, and updated demand forecasts, determining, by an optimization controller, a time to-trigger, and a cut-off time, and an updated demand forecast, the time-to-trigger defining an interval, at which the set of routes for delivery of assets is to be re-optimized, in response to the time-to-trigger being achieved, re-optimizing, by a route optimization module of the continuous delivery platform, the set of routes to provide a revised set of routes, and conveying at least one route of the revised set of routes to a delivery personnel, the at least one route being different from any route in the set of routes, and being executed during the period. 0 _0 o E Io 0I I;- Io 0 L 0 -Oa~. 0o IM ClL U I2 -a (3) CL 0 = -~. I C14~-IU ca E
Patent AU-2019249374-A1 (AU)
Title: Compositions and methods for the treatment of dominantly-inherited catecholaminergic polymorphic ventricular tachycardia
Inventor: PRIORI SILVIA G
IPC: A61K48/00
Filed: 2019-04-05
Abstract: The disclosure features compositions and methods for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), particularly forms of the disease that are inherited in an autosomal dominant manner, by way of calsequestrin 2 (CASQ2) gene therapy. The compositions and methods described herein can be used to treat CPVT caused by mutations in, for example, ryanodine receptor 2 and calmodulin, such as calmodulin 1 (CALM1) and CALM3. The disclosure provides a variety of vectors that can be used for the delivery of a CASQ2 transgene to a patient, such as a human patient suffering from autosomal dominant CPVT, including adeno-associated virus vectors, among others.
Patent AU-2019251356-A1 (AU)
Title: Oncolytic adenovirus compositions with enhanced replication properties
Inventor: MIYAKE-STONER SHIGEKI
IPC: A61K35/761
Filed: 2019-04-09
Abstract: Tumor-selective recombinant adenoviruses that possess deletions or modifications in the E3 region are described. Recombinant adenoviruses that express adenovirus death protein (ADP) but have a deletion of at least three of the remaining six E3 genes exhibit enhanced virus replication. The recombinant adenoviruses further include additional modifications to allow selective replication in tumor cells and to detarget viruses from the liver. Use of the recombinant adenoviruses for cancer treatment is described.
Patent AU-2019257411-A1 (AU)
Title: Modular Crossbar
Inventor: LOVÉN ALEX
IPC: A63B63/00
Filed: 2019-10-29
Abstract: Abstract Modular Crossbar The invention relates to a frame assembly (100) for a sports goal comprising: at least two frame members (101) each comprising an internal channel (103) defined by a respective frame member casing and an external channel (104) formed upon the casing; wherein the frame member casings comprises a plurality of apertures (105) extending between the internal and external channels; an insert (130) disposable within the internal channel, having a plurality of apertures (135) alignable with the plurality of apertures (105) of the frame member casings; a first plurality of fixing members (110) configured to extend through the plurality of apertures (105) of the frame member casings and insert thereby connecting the frame members and insert; a second plurality of fixing members (120) disposable within the external channel (104) of the frame members; a plate (140), disposable within the external channel (104), having a first plurality of apertures (142) alignable with the second plurality of fixing members and a second plurality of apertures (146) configured to receive a connection means for supporting a goal net. Yv •L -90
Patent AU-2019263121-A1 (AU)
Title: Systems and methods for applying an agricultural practice to a target agricultural field
Inventor: BEN-NER ZOHAR
IPC: G06Q50/02
Filed: 2019-05-02
Abstract: There is provided a method comprising: computing state parameter(s) indicative of a state of a target crop at the target field based on output of crop physiological sensor(s), and classifying by a classifier(s), the state parameter(s) and the agricultural practice(s) into instructions for administration of the agricultural practice(s) to the target field, wherein yield and/or quality of the target crop at a future target event is predicted to be increased when the instructions are implemented relative to the yield and/or quality of the target crop that is predicted at the future target event when an alternative administration of the agricultural practice(s) is implemented, wherein the classifier(s) computes the instructions based on previously obtained instructions associated with respective reference fields associated with respective state parameter(s), and yield and/or quality of respective reference crops at respective reference fields at historical reference events corresponding to the future target event.
Patent AU-2019275566-A1 (AU)
Title: Pressurization processing system
Inventor: SATO TAKANORI
IPC: F16J13/00
Filed: 2019-12-03
Abstract: A pressurization processing system that performs pressurization processing on a target by immersing the target in the sea or a lake, includes a housing body that is configured to house the target, a buoyancy body that is configured to float the housing body, a weight body that has a specific gravity greater than that of seawater or lake water, and a separation mechanism that separably connects the housing body and the weight body. In the system, the buoyancy body includes a housing bag having water permeability, and the housing bag houses a plurality of hollow glass spheres, and is immersed in the seawater or the lake water so that a space between the plurality of hollow glass spheres housed in the housing bag is filled with the seawater or the lake water. p - 2 P--TG
Patent AU-2019289210-A1 (AU)
Title: Skin treatment apparatus
Inventor: LIU BENJAMIN
IPC: A45D29/00
Filed: 2019-06-21
Abstract: A roller head for a skin treatment device configured to drive the roller head by an electro-mechanical mechanism; a surface of the roller head comprises at least one peak, the at least one peak is arranged so that, when in use, a first surface of the peak contacts with the skin with when the roller head rotated in a clockwise direction and a second surface of the peak contacts with the skin with when the roller head rotated in an anticlockwise direction wherein the first surface differs from the second surface and the first surface is configured to provide a first benefit and the second surface is configured to provide a second benefit.
Patent AU-2019321847-A1 (AU)
Title: Production of alcohol-free fermented vegetable juice with pichia kluyveri yeast
Inventor: SAERENS SOFIE
IPC: A23L2/70
Filed: 2019-07-23
Abstract: The invention relates to methods of preparing vegetable juice comprising fermenting a vegetable substrate with a
Patent AU-2019326539-A1 (AU)
Title: Use of gaboxadol in the treatment of gastrointestinal tract disorders and asthma
Inventor: DURING MATTHEW
IPC: A61K31/437
Filed: 2019-08-22
Abstract: Treatment of irritable bowel syndrome, Crohn's disease, celiac disease, ulcerative colitis, microscopic colitis, and asthma using gaboxadol or a pharmaceutically acceptable salt thereof is provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of irritable bowel syndrome, Crohn's disease, celiac disease, ulcerative colitis, microscopic colitis, or asthma.
Patent AU-2019326933-A1 (AU)
Title: Heteroaromatic compounds as Vanin inhibitors
Inventor: GODBOUT CÉDRICKX
IPC: A61K31/4375
Filed: 2019-08-26
Abstract: The present invention encompasses compounds of the formula (I) which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
Patent AU-2019355933-A1 (AU)
Title: Software testing
Inventor: CSER TAMAS
IPC: G06F11/00
Filed: 2019-10-02
Abstract: Provided herein is technology relating to testing software and particularly, but not exclusively, to methods for identifying the cause of a failed software test using probabilistic graphical models and/or a rules engine to evaluate and sort test steps by likelihood of failure for dynamic applications.
Patent AU-2019388457-A1 (AU)
Title: Bicycle linkage
Inventor: HOSKINS PHILLIP
IPC: B62M1/00
Filed: 2019-11-29
Abstract: A bicycle (1) has an instant centre (IC) and including separate front and rear frames (2,3). The front frame (2) is supported by a front wheel (6b) and the rear frame (3) is supported by a rear wheel (6a) rotatable about a rear hub (9). A set of pivoting members (4) connect the front and rear frames (2,3) through pivotal connections (11a-b,13a-c,21a-b,23-24) and a biased dampening device (16). The pivoting members (4) include a lower member (22) extending from a first lower join (21) a to a second lower join (21b), and a mid member (20) extending from a forward mid pivot (24) to a rear mid pivot (23). The forward mid pivot (24) and the second lower join (21b) are connected to the front frame (2) at pivots 21b, (24) with fixed axes relative to the front frame (2). The instant centre (IC) moves rearwardly and downwardly from a first resting position to a second activated position, through a path (50) intersecting the forward mid pivot (24) and a substantially horizontal cylindrical footprint corresponding to the axial bore of the forward mid pivot (24).
Patent AU-2019409777-A1 (AU)
Title: Two-times-two tank process and system
Inventor: HOLTE HANS RASMUS
IPC: C12P5/02
Filed: 2019-11-28
Abstract: A method and plant for hydrolysis of a liquid substrate, having a dry solids content of between 2 and 30 %, to be used in an anaerobic fermentation, digestion or another process aimed at producing or extracting methane or other valuable substances, which method and plant relies on the use of vacuum and several pulpers and one or several flashtanks in series for step-wise pre-heating and pressure reduction, respectively.
Patent AU-2019440196-A1 (AU)
Title: Reconfigurable container-closure system
Inventor: CHEN YUN
IPC: B65D81/32
Filed: 2019-04-12
Abstract: A reconfigurable container-closure system is comprised of first and second containers and first and second closures. The container- closure system can assume either of two configurations. First configuration means that the first closure (12) is secured to the first container (10), and the second closure (112) is secured to the second container (110). Also, an orifice reducer (113), cartridge (114) and sleeve (115) are all attached to the second closure (112), and two products are separated. Second configuration means that the second closure (112) is secured to the first container (10), and the first closure (12) is secured to the second container (110). Also, the orifice reducer (113), cartridge (114) and sleeve (115) are all attached to the first container (10), and two products are allowed to mix and be dispensed. The transfer is accomplished by a user who simply screws the second closure onto the first container (10).
Patent AU-2019447663-A1 (AU)
Title: Conical self-positioning limiting feeding device and method
Inventor: HOU YALI
IPC: B26D7/06
Filed: 2019-10-30
Abstract: Provided are a conical self-positioning limiting feeding device and a method, comprising a bearing pot (I-01), an empty circle is reserved at the center of the bearing pot (I-01), a U-shaped slide way (I-11) is formed between the inner circle and the outer circle, a rotating evacuation cone (I-12) and a limiting feeding rod (I-04) are arranged in the bearing pot (I-01), the rotating directions of the rotating evacuation cone (I-12) and the limiting feeding rod (I-04) are the same, and the rotating speed of the rotating evacuation cone (I-12) is greater than that of the limiting feeding rod (I-04); material is placed in the bearing pot (I-01), the rotating evacuation cone (I-12) rotates, and through the torque generated by the friction force between the rotating evacuation cone (I-12) and the material, the material is enabled to rotate in the U-shaped slide way (I-11) of the bearing pot (I-01) until the long axis of the material is tangent to the radius of the rotating evacuation cone (I-12); the limiting feeding rod (I-04) rotates, and uniformly and intermittently pushes the materials to an outlet so as to realize the arrangement in the material long-axis direction.
Patent WO-2020198801-A1 (WO)
Inventor: COLE COLIN
IPC: B61L3/00
Filed: 2020-04-03
Abstract: A method for monitoring operating conditions of a vehicle or infrastructure network, the method comprising the steps of: a) Associating one or more sensors with one or more vehicle components and/or infrastructure components; b) Acquiring measurements of one or more operating parameters of the one or more vehicle components and/or infrastructure components using the one or more sensors; c) Transmitting the measurements of the one or more operating parameters to an operating parameter monitoring device; d) Converting the measurements into an output signal message indicating the presence or absence of a fault in the one or more vehicle components and/or infrastructure components using the operating parameter monitoring device; and e) Transmitting the output signal message electronically to one or more recipients.
Patent WO-2020248021-A1 (WO)
Title: Balloon for expanding an orifice
Inventor: JAMES ANDREW E
IPC: A61M29/02
Filed: 2020-06-12
Abstract: A balloon is disclosed for expanding an orifice. The balloon comprises a hollow body having a head. The body is closed at a distal end and open at a proximal end. The head extends from the distal end. The balloon also comprises a hollow neck positioned between the open proximal end and the distal end of the body. In the balloon, a wall thickness of the neck is greater than a wall thickness of the head. In a variation, the balloon can be configured such that, when the balloon is inflated, the head expands in a radial direction greater than in the longitudinal direction and a diameter of the body remains approximately constant during inflation. Also disclosed is a system for expanding an orifice. The system includes such a balloon and an inflation device for inflating the balloon. Also disclosed is a kit comprising the system and a container. Further, disclosed is a mould and a method for forming the balloon.
Patent WO-2021051168-A1 (WO)
Title: Imaging and therapeutic compositions
Inventor: DONNELLY PAUL STEPHEN
IPC: C07C49/593
Filed: 2020-09-18
Abstract: The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging and therapeutic agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
Patent AU-2020202666-A1 (AU)
Title: Interlock system for autonomous vehicle
Inventor: WHITFIELD JR JAMES
IPC: B60K35/00
Filed: 2020-04-21
Abstract: The present application relates to a vehicle comprising a vehicle control system, the 
vehicle control system being configured to operate the vehicle in an autonomous mode and in a 
manual mode, the vehicle control system comprising: a first selector switch for switching 
between said autonomous mode and said manual mode; a second selector switch for switching 
between said autonomous mode and said manual mode; and an interlock circuit configured to 
deactivate propulsion of the machine when the first and the second selector switch are switched 
to different modes.
Patent AU-2020203467-A1 (AU)
Title: Email verification method
Inventor: MACHET JEREMY
IPC: G06F21/64
Filed: 2020-05-26
Abstract: The invention provides a method of generating and verifying one or more emails sent by a valid sender (1) to an intended recipient (2), the method comprising the steps of: receiving (101,21) from the valid sender (1) a content of a recipient email and a recipient email address; generating (102,22) one or more encrypted hash codes (81) using a hash code generating algorithm, the hash code generating algorithm utilising a private encryption key and the content of the recipient email or metadata of the recipient email; storing (103) in an encryption memory (23) the one or more encrypted hash codes or information enabling regeneration of the one or more encrypted hash codes (81); generating (104,25) the recipient email comprising the content of the recipient email augmented with the one or more encrypted hash codes (81); sending (105,30) the recipient email to an intended recipient email address; receiving (106,28) a verification request email from a verification requestor email address, the verification request email comprising a purported forwarded copy of an email sent by the valid sender (1) to the intended recipient (2); determining (107,26) a verification result according to a verification criterion requiring at least for a positive result that there is a concordance according to a comparison criterion involving the hash codes; and sending (108,27) a verification signal disclosing the verification result to the intended recipient by a non-email route (4,3). a Lii -) 8 2. -.- w o -Hu >- m , o - > LJ >> cn Z cr c 42 u C ~ ~0w i~ U ~ Li inC
Patent AU-2020210211-A1 (AU)
Title: A modular partition and fabrication thereof
Inventor: CHERNIAKOV DANIEL
IPC: B32B3/06
Filed: 2020-07-29
Abstract: A modular device adapted for subdividing room space, the modular device comprising: a 
panel comprising a corrugated portion positioned between a first planar surface and a second 
planar surface of the panel, wherein the peaks of the corrugated portion are in engagement 
with the first planar surface, wherein the troughs of the corrugated portion are in 
engagement with the second planar surface; the first planar surface and the second planar 
surface each having a first end and a second end; wherein the first and second ends of the 
first planar surface are respectively opposite relatively to the first and second ends of the 
second planar surface; the second planar surface is parallel to the first planar surface; wherein 
the corrugations are is parallel to the vertical axis of the panel; a concave female portion 
positioned along the vertical axis in the panel, wherein the concave female portion is formed 
from at least: the first end of the first planar surface, the first end of the second planar surface, 
and a curved portion from the corrugated portion; a convex male portion positioned along 
the vertical axis of the panel, wherein the convex male portion is positioned outside of the 
second end of the first planar surface and the second end of the second planar surface; 
wherein to extend the length of the panel, the convex male portion of a first panel is adapted 
to engage with the concave female portion of a second panel.
1/9 
10 
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02 
FIG. A 
28 
422 
28 
42 
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32 
FIG. B FIG. C