Patent SG-11201908179U-A (SG)
Title: Aryl cyclopropyl-amino-isoquinolinyl amide compounds
Inventor: DELONG MITCHELL
IPC: C07D217/22
Filed: 2018-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit °nolo HE mil mu HE mo oimIE (10) International Publication Number WO 2018/183911 Al (51) International Patent Classification: CO7D 217/22 (2006.01) CO7D 217/24 (2006.01) (21) International Application Number: PCT/US2018/025494 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/480,239 31 March 2017 (31.03.2017) US 62/643,131 14 March 2018 (14.03.2018) US (71) Applicant: AERIE PHARMACEUTICALS, INC. [US/US]; 2030 Main Street, Suite 1500, Irvine, CA 92614 (US). (72) Inventors: DELONG, Mitchell, A.; 212 Hillcrest Circle, Chapel Hill, NC 27514 (US). STURDIVANT, Jill, M.; 3930 Crawford Dairy Road, Chapel Hill, NC 27516 (US). LICHOROWIC, Cynthia, L.; 8510 Brittdale Lane, #201, Raleigh, NC 27617 (US). KORNILOV, Andriy; 4816 Lakeridge Drive, Apt. 1A, Ypsilanti, MI 48197 (US). (74) Agent: CULLMAN, Louis, C. et al.; K&L Gates LLP, 1 Park Plaza, Twelfth Floor, Irvine, CA 92604 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (54) Title: ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS (57) : Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides com- pounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovas- cular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.