Patent DE-102007018149-A1 (DE)
Title: Substituted compound for producing pharmaceuticals for treating or prophylaxis of pain, nerve injuries, respiratory disorder, has general formulae
Inventor: FRANK ROBERT
IPC: C07D265/36
Filed: 2007-04-16
Abstract: The substituted compound has general formulae (I-V). The substituted compound having general formulae (I-V), are new. n : 0-4; R 1>, R 2>e.g. -CH=N-NH-, -CH=N-NR 7>1-, -S-C(=S)-NH-, -O-C(=S)-NH-, -S- C(=O)-NH-, -O-C(=O)-NH-, -S-C(=S)-NR 6>3-, -NH-C(=O)-NH-, -NH-C(=S)-NH-, -O-CH 2-CH 2-NH- or -CH=CH-N=CH-; R 3>, R 4>e.g.-CH=N-NH-, -CR 2>8=N-NH-, -CH=N-NR 6>2-, -CR 2>8=N- NR 6>2-, -S-C(=S)-NH-, -O-C(=S)-NH-, -S-C(=O)-NH-, -O-C(=O)-NH-, -S- C(=S)-NR 6>3-, -O-C(=S)-NR 6>3-, -S-C(=O)-NR 6>3-, -O-C(=O)-NR 6>3- or -S-CH=N; R 4>, R 5>e.g.-CH=N-NH-, -CH=N-NR 7>1-, -O-C(=O)-NR 6>3-, -S-CH=N-, -S-CR 2>9=N-, -N=CH-O-, -O-CH 2-CH 2-NH- or -CH=CH-N=CH-, R 6>H or linear or branched, subsitituted or unsubstituted; R 7>H or -OH; R 8>-SF 5, -O-CF 3, -CF 3, -O-CFH 2, -O-CF 2H, -CFH 2, -CF 2H, or a unsubstitueted or a substitueted tert-butyl; T : C-R 3>5, N; U : C-R 3>6, N; V : N, C-R37, N; and W : C-R 3>8, R 9> R 1>0, R 1>1, R 1>2, R 1>3, R 1>4, R 1>5, R 1>6, R 1>7, R 1>8, R 1>9, R 2>0, R 2>1, R 2>2, R 2>3, R 2>4, R 2>5, R 2>6 and R 2>7, R 2>8=F, Cl, Br, I, -SF 5, -NO 2, -CF 3, -CN, chain for NH 2 or saturated or unsaturated or a substituted 1-10C aliphatic residue, R 2>9, R 3>0=-NH-C(=O)-R 3>1, NH 2, NHSO 2R 3>2, -NH-C(=O)-O-R 3>3, -S-R 3>4, R 3>1, R 3>2, R 3>3 and R 3>4=linear or a branched or a simple subsitituted 1-10C residue, R 3>5, R 3>6, R 3>7=H, F, Cl, Br, I, -SF 5, -NO 2, -CF 3, -CN, -NH 2, -OH, -SH, -C(=O)-NH 2, -S(=O) 2-NH 2, -C(=O)-NH-OH, -C(=O)-OH, -C(=O)-H, -S(O) 2-OH, -NHR 1>3, -NR 1>4R 1>5, -NH-C(=O)-R 1>3, -S(=O)2-R 2>7, R 3>8=H, F, Cl, Br, I, -SF 5, -NO 2, -CF 3, -CF 2CI, -CN, -NH 2, -OH, -SH, -C(=O)-NH 2, -S(=O) 2-NH 2, -C(=O)-NH-OH, COOH, C(O)H, - S(=O) 2-OH, -NHR 3>9, -NR 4>0R 4>1, -OR 4>2, -SR 4>3, -C(=O)-NHR 4>4, -C(O)- NR 4>5R 4>6, S(O) 2-NHR 4>7, -S(=O) 2-NR 4>8R 4>9, -C(=O)-OR 5>0, -C(=O)-R 5>1, S(O)R 5>2, SO2R 5>3, -C(=NH)NH 2, -C(=NH)-NH-R 5>4, -N=C(NH 2) 2, -N=C(NHR 5>5KNHR 5>6), R 3>9, R 4>0, R 4>1, R 4>2, R 4>3, R 4>4, R 4>5, R 4>6, R 4>7, R 4>8, R 4>9, R 5>0, R 5>1, R 5>2, R 5>3, R 5>4, R 5>5, R 5>6, independently, in each case linear or branched, saturated or unsaturated or a simpl substituted 1-10C aliphatic residue, R 5>7=-NHR 5>8, -NR 5>9R 6>0 saturated or unsaturated or a simple substituted 1-10C aliphatic residue, R 5>8, R5 9> and R 6>0=-C(=O)-R 6>1, R 6>1, R 6>2, R 6>3, R 6>4, R 6>5, R 6>6 and R 6>7= saturated or unsaturated or unsubstituted or a simply substituted 1-10C aliphatic residue, R 6>8, R 6>9 and R 7>0=independently, in each case for F, Cl, Br, I or saturated or unsaturated or unsubstituted or a simply substituted 1-10C aliphatic residue, R 7>1=for unsubstituted or substituted aryl or hetero aryl residue, or over a linear or a branched,unsubstituted or a simply substituted 1-6C -alkyl or 2-6C alkenyle or 2-6C alkinyl. [Image] [Image] [Image] [Image] [Image] ACTIVITY : Analgesic; Antimigraine; Neuroprotective; Dermatological; Antiparkinsonian; Nootropic; Anticonvulsant; Respiratory-Gen; Antiasthmatic; Antiinflammatory; Antitussive; Uropathic; Gastrointestinal-Gen; Ophthalmological; Antidiarrheic; Antipruritic; Osteopathic; Antiarthritic; Antirheumatic; Eating-Disorders-Gen; Vasotropic; Hypotensive. MECHANISM OF ACTION : Vanilloid receptor agonist.