Patent SG-11201804836R-A (SG)
Title: Treatment of fibrosis
Inventor: COOK STUART ALEXANDER
IPC: C07K16/28
Filed: 2016-12-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res.. 00) (43) International Publication Date ..... ....rel 22 June 2017(22.06.2017) WIPO I PCT (10) WO International 1111111111113111111111111111111111111111111111111111111111111111111111111111111111111111 2017/103108 Publication Al Number (51) International Patent Classification: bastian; 76 Shenton C07K 16/24 (2006.01) A61K 39/00 (2006.01) 079119 (SG). C07K 16/28 (2006.01) (74) Agents: CLEGG, Richard (21) International Application Number: City Tower, 40 Basinghall PCT/EP2016/081430 EC2V 5DE (GB). (22) International Filing Date: (81) Designated States (unless 16 December 2016 (16.12.2016) kind of national protection AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, DZ, EC, EE, EG, HN, HR, HU, ID, IL, (30) Priority Data: KP, KR, KW, KZ, LA, 1522186.4 16 December 2015 (16.12.2015) GB MD, ME, MG, MK, Way, 76 Shenton #24-04, Singapore et al.; Mewburn Ellis LLP, Street, London, Greater London otherwise indicated, for every available): AE, AG, AL, AM, ES, FI, GB, GD, GE, GH, GM, GT, IN, IR, IS, JP, KE, KG, KH, KN, LC, LK, LR, LS, LU, LY, MA, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PA, (71) Applicants: SINGAPORE HEALTH SERVICES PTE OM, LTD [SG/SG]; #03-03, Bowyer Block, 31 Third Hospital RU, RW, SA, SC, SD, Avenue, Singapore 168753 (SG). NATIONAL UNIVER- TH, TJ, TM, TN, TR, ZA, ZM, ZW. SITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (84) Designated States (unless (71) Applicant (for LS only): CLEGG, Richard Ian [GB/GB]; kind of regional protection City Tower, 40 Basinghall Street, London, Greater London GM, KE, LR, LS, MW, PE, PG, PH, PL, PT, RO, RS, QA, SE, SG, SK, SL, SM, ST, SV, SY, TT, TZ, UA, UG, US, UZ, VC, VN, otherwise indicated, for every available): ARIPO (BW, GH, MZ, NA, RW, SD, SL, ST, SZ, EC2V 5DE TZ, UG, ZM, ZW), Eurasian (GB). (AM, AZ, BY, KG, KZ, RU, TJ, TM), European AT, BE, BG, CH, CY, CZ, DE, (AL, (72) Inventors: COOK, Stuart Alexander; 6 Sunset Square, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Clementi Park, Singapore 597304 (SG). SCHAEFER, Se- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: TREATMENT OF FIBROSIS b li wP NE sled Genes TOFU i + An) c d 0 1.5 ° 40 ct.. .— u o a o 5 c Il — 2O , 0 5 .4t : r Ge 0 O 0 5 10 15 21 25 TGEB1 4- - -- 1 11_11 RNA-Seq) M 0 1-1 Figure 1 - -- 1 (57) (57) : The treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of in- 0 hibiting the action of Interleukin 11 (IL-11) is disclosed. ei 0 WO 2017/103108 Al MIONIMOREIDEDIDEMOMOMMIDMOIDIREMEUDIME SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, before the expiration of the time limit for amending the GW, KM, ML, MR, NE, SN, TD, TG). claims and to be republished in the event of receipt of Declarations under Rule 4.17: amendments (Rule 48.2(h)) — of inventorship (Rule 4.17(iv)) — with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art 21(3))