baber/WOPTO huggingface dataset:
Patent EP-1215203-B1 (EP)
Inventor: KONNO MITOSHI
IPC: A61P13/12
Filed: 2000-09-22
Granted: 2005-02-16
Abstract: Hydroxamic acid derivatives of the formula (I) <CHEM> (wherein all the symbols have the same meaning as defined in the specification.),  non-toxic salts thereof or prodrugs thereof. The compounds of the formula (I) inhibit producing IL-6, so it may be used for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, hypergammaglobulinemia, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmne diseases, hepatitis, colitis, graft versus host disease, infectious diseases and endometriosis.
Patent EP-1212442-B1 (EP)
Inventor: GELVIN STANTON B
IPC: C12N5/10
Filed: 2000-09-14
Granted: 2005-05-18
Abstract: Adding at least one gene involved in plant host cell T-DNA integration enhances transformation by <i>Agrobacterium</i>. The histone H2A gene encoded by the <i>Arabidopsis</i> RAT5 gene increases transformation frequencies of plants, most likely by causing overexpession of a product needed for T-DNA integration. <i>Agrobacterium tumefaciens</i> genetically transforms plant cells by transferring a portion of the bacterial Ti-plasmid, designated the T-DNA, to the plant, and integrating the T-DNA into the plant genome. However, not all plants are transformable by <i>Agrobacterium</i> and transformation frequencies may be too low to be useful. Little is known about the T-DNA integration process, and no plant genes involved in integration have been identified prior to the present invention.
Patent EP-1221968-B1 (EP)
Inventor: O'HAGAN DEREK
IPC: A61K39/21
Filed: 2000-10-10
Granted: 2010-01-13
Abstract: A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.
Patent EP-1226316-B1 (EP)
Inventor: RINGHOFER JOSEF
IPC: E03F1/00
Filed: 2000-10-19
Granted: 2006-12-13
Abstract: L'invention concerne un procédé et un dispositif pour rincer périodiquement une canalisation d'eau usée (1). Selon l'invention, une quantité d'eau est recueillie dans un collecteur (8) qui est relié à l'extrémité d'entrée de la canalisation (1) à la manière d'une cuve communicante et qui est alimenté périodiquement en air comprimé par l'intermédiaire d'un réservoir de pression, tandis que l'arrivée d'eau vers le collecteur (8) est obturée au moyen d'une unité d'obturation (13) pour faire passer par à-coups la quantité d'eau contenue dans le collecteur à travers la canalisation (1) au moyen de l'air comprimé.
Patent EP-1238276-B1 (EP)
Inventor: SCHULZE ZUR WIESCHE ERIK
IPC: G01N33/50
Filed: 2000-12-06
Granted: 2004-03-03
Abstract: A process is provided for determining the degree of damage to keratinous fibers. The process includes providing a container containing a liquid preparation, introducing keratinous fibers into the container, and applying at least one impulse to the container to determine the degree of damage. The liquid preparation contains at least two immiscible continuous liquid phases, where the phases differ in densities at 20° C. by at least 0.04 g/ml.
Patent EP-1221954-B1 (EP)
Inventor: CHANG YIE-HWA
IPC: C07K5/083
Filed: 2000-10-12
Granted: 2006-09-13
Abstract: Methods are provided for detecting methionine aminopeptidase (MAP) activity and for detecting inhibitors of MAP. The methods utilize a peptide comprising an N-terminal methionine which can be cleaved from the peptide by MAP, and a C-terminal detection moiety which is released by a second peptidase only if the N-terminal methionine has been cleaved from the peptide. When the peptide is combined with MAP and the second peptidase, the detection moiety is released, while the addition of a MAP inhibitor will inhibit the release of the detection moiety. Reaction mixes, peptides, and kits which are useful for practicing the methods are also provided.
Patent EP-1240337-B1 (EP)
Inventor: DELANO WARREN L
IPC: C12N15/09
Filed: 2000-12-22
Granted: 2006-08-23
Abstract: Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may comprise any molecule having utility as a therapeutic or diagnostic agent. The hybrid molecules of the invention may be prepared using any of a number techniques including production in and purification from recombinant organisms transformed or transfected with an isolated nucleic acid encoding the hybrid molecule, or by chemical synthesis of the hybrid. The hybrid molecules have utility as agents to alter the elimination half-times of active domain molecules. Elimination half-time is altered by generating a hybrid molecule of the present invention wherein the peptide ligand has binding affinity for a plasma protein. In a preferred embodiment, a bioactive molecule having a short elimination half-time is incorporated as or into an active domain of the hybrid molecules of the invention, and the binding affinity of the peptide ligand domain prolongs the elimination half-time of the hybrid as compared to that of the bioactive molecule.
Patent EP-1282430-B1 (EP)
Inventor: PORTER WILLIAM LESLIE
IPC: A61P37/02
Filed: 2000-12-20
Granted: 2005-11-23
Abstract: A preparation and use thereof for modulating immune response, comprising lipids comprising esters of glycerol (propane 1,2,3-triol) with fatty acids, also including 1,2-di-O-acylglycerols joined at oxygen by a glycosidic linkage to a carbohydrate, also derivatives of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid as mono- or diesters and the other two are esterified with fatty acids, thus excluding those organic compounds consisting of a trisaccharide repeating unit with oligosaccharide side chains and acyl or amine linked fatty acid.
Patent EP-1142038-B1 (EP)
Inventor: PEASE JOHN
IPC: H02N2/14
Filed: 2000-11-03
Granted: 2008-06-11
Abstract: L'invention concerne un procédé et un appareil de commande d'un actionneur piézo-électrique couplé à un élément commandé. Cet actionneur (212) réagit aux formes d'ondes (2040, 204) avec des profils tension/courant asymétriques sur les flancs montant et descendant de manière à impartir un mouvement régulier et en chaîne de l'élément commandé dans une des deux directions des mouvements alternatifs de l'actionneur piézo-électrique. Les formes d'ondes sont générées numériquement à partir d'un ensemble de nombres mémorisés ou avec une fonction servant à générer l'ensemble de nombres. Ces nombres correspondent aux valeurs numériques discrètes associées aux formes d'ondes souhaitées permettant le déplacement de l'élément commandé dans une des au moins deux directions. Le contrôleur peut être utilisé pour commander plus d'un actionneur piézo-électrique et être doté d'une sensibilité à une rétroaction de la position de l'élément commandé pour placer l'élément commandé avec précision. Le contrôleur peut aussi être capable de mettre à jour la fonction ou les valeurs stockée(s) dans la mémoire de manière à se coupler plus efficacement avec de nouveaux actionneurs ou des actionneurs existants.
Patent EP-1252433-B1 (EP)
Inventor: BOECKING FRIEDRICH
IPC: F02M61/10
Filed: 2000-11-10
Granted: 2005-08-31
Abstract: L'invention concerne une soupape d'injection de carburant (16) présentant un obturateur (24) qui commande au moins un orifice d'injection (26). Le déplacement de l'obturateur (24) est commandé par une soupape de commande (18) qui présente un obturateur (62). Ce dernier commande la pression régnant dans une chambre de pression de commande (48) et peut être déplacé par une force de positionnement produite par un piézo-actionneur (80) pour commander ainsi l'établissement d'une communication entre la chambre de pression de commande (48) et une chambre de détente (12). La soupape de commande (18) présente deux sièges (60, 74) placés à distance l'un de l'autre dans le sens de déplacement de l'obturateur (62). Lesdits sièges coopèrent avec ce dernier par l'intermédiaire d'une surface d'étanchéité respective (66, 69) placée sur ledit obturateur (62), de sorte que ce dernier présente deux positions de fermeture, dans lesquelles la chambre de pression de commande (48) ne communique pas avec la chambre de détente (12). Lorsque l'obturateur (12) ne se trouve pas dans une de ces deux positions de fermeture, la chambre de pression de commande (48) communique avec la chambre de détente (12). Un déplacement de l'obturateur (62) entre ses deux positions de fermeture permet l'ouverture brève de la soupape d'injection de carburant (16).
Patent EP-1136763-B1 (EP)
Inventor: PISTILLO CIRO FRANCESCO
IPC: F24F1/00
Filed: 2001-03-12
Granted: 2005-11-02
Abstract: A box for the internal flush-mounted unit of air conditioners, comprising a box-like flush-mounting body (10) which accommodates the components that form the internal unit and is provided with treated air passage channels, respective expulsion outlets (13), integrated in a covering base (14) to be installed in view and provided with an intake grille (17), being associated by insertion with the axially orientated exits (12) of the channels. <IMAGE>
Patent EP-1260772-B1 (EP)
Inventor: HUANG CHEN PAN
IPC: F24F6/00
Filed: 2001-05-15
Granted: 2006-08-30
Abstract: A humidifier includes a float (4) positioned at a water outlet of a water tank (2), and a body (1) containing a water level sensor (12) functioning with the float rising and falling with the level of the water in a water chamber in the body to drive the water level sensor in case of the water level falling to the lowest to turn off the humidifier. Then the water tank is simplified in its structure and making the humidifier safe to use. <IMAGE>
Patent EP-1160719-B1 (EP)
Inventor: AHLERS BENEDIKT DR
IPC: G06K7/10
Filed: 2001-05-26
Granted: 2010-09-29
Abstract: The sensor subjects the marker to stimulation wavelengths. If appropriate the marker responds with different wavelengths detected and evaluated by a radiation receiver. A beam from a radiation source is converted by focusing optics so that an approximately linear sampling line is projected onto the document to at least partly illuminate the marker to cause fluorescence. The fluorescent signal is passed by detection optics to an evaluation unit.
Patent EP-1236521-B1 (EP)
Inventor: POZZI PAOLO
IPC: B08B9/087
Filed: 2001-06-15
Granted: 2005-11-23
Abstract: A device for cleaning the inner surfaces of containers in general which comprises, on a supporting frame (1), a body (22,24) for coupling to the mouth of a container to be cleaned. A brush-like element (30) is further provided, which can be inserted in the container (23,25) and can perform a translational motion and a rotation with respect to the axis of the container (23,25). A washing head (41) is provided coaxially to the brush-like element (30) and is able to perform a translational motion with respect to the brush-like element (30). <IMAGE>
Patent EP-1172696-B1 (EP)
Inventor: KAWAMURA KOICHI
IPC: G03F7/11
Filed: 2001-07-12
Granted: 2006-10-04
Abstract: A novel lithographic printing plate precursor is disclosed, comprising a crosslinked hydrophilic layer having a crosslinked structure and containing a hydrophilic polymer compound having a hydrophilic graft chain, provided on a support.
Patent EP-1177780-B1 (EP)
Inventor: BARONE HECTOR DANIEL
IPC: A61F2/86
Filed: 2001-08-01
Granted: 2008-03-26
Abstract: A multi-component stent-graft assembly for repairing a lesion in a blood vessel, preferably a thoracic dissecting aneurysm, the assembly comprising a frame stent that is affixed to the vessel, in the healthy portions of the vessel and extending along the entire lesion of the vessel, and a stent-graft which is affixed against the inside of the frame stent, the stent-graft being located at the desired locations within the affected portion of the vessel no matter the vessel wall is in conditions to retain the stent-graft, because the retention will be provided by the frame stent. <IMAGE>
Patent EP-1199107-B1 (EP)
Inventor: RITSCHE STEFAN
IPC: B05B11/00
Filed: 2001-10-13
Granted: 2007-06-06
Abstract: In a dispenser, particularly an atomizer, which is used for flowable substances, particularly pharmaceuticals, use is made of a pump, which must be actuated one or more times for priming purposes. Its discharge nozzle (14) is covered by a protective cap (38), which is suitable to collect and store the medium, which is discharged during the priming strokes and before the start of the useful strokes. During the priming strokes the protective cap (38) is secured on the dispenser (11). This is brought about in that a locking (40) for the protective cap is only released when the priming strokes have been performed. This can take place by electrical actuation or by material change under the influence of the medium to be discharged. According to a variant the protective cap is not itself locked, but an actuation locking takes place if the protective cap has not been fitted for the priming strokes.
Patent EP-1201391-B1 (EP)
Inventor: ADELHANOFF M YVES
IPC: B29B17/00
Filed: 2001-10-25
Granted: 2008-07-09
Abstract: The raw waste is shredded and/or crushed. It is then agglomerated. It is mixed before, during or after agglomeration with a plasticizer and/or an elastomeric charge. The resulting mixture can be transformed for injection molding.  Preferred Features: The wastes are mixed with a plasticizer and/or a charge of elastomer forming 5%-10% of the weight of the mixture. Following shredding and/or crushing, agglomeration and mixing takes place, then the plasticizer and/or elastomer are mixed in. The mixture is then introduced into the injection molding press. The mixing process is one of compounding to form a liquefied mixture. This is cooled then granulated in readiness for injection molding. Compounding takes place in a single- or dual-screw extruder with different feed hoppers for the prepared waste and for the plasticizer or elastomeric charge. The liquefied mixture passes through a die producing continuous filaments or -strands, followed by cooling and granulating for injection molding.
Patent EP-1136471-B1 (EP)
Inventor: BERMEJO OSES MARIA JOSE
IPC: A61K8/41
Filed: 2001-03-16
Granted: 2003-07-16
Abstract: Alkanolamine esters obtainable by reaction of alkanolamine (I) with dicarboxylic acid (II) and optionally alkoxylated fatty alcohol (III) are new. Cationic surfactants and esterquats obtained from the esters are also new. Alkanolamine esters obtainable by reaction of an alkanolamine of formula (I) with a dicarboxylic acid (or reactive derivative) of formula (II) and with a fatty alcohol, optionally alkoxylated, of formula (III) are new. HOOC-R4-COOH      (II) R1 = H, 1-6C alkyl or the residue -R2-O(CHR3CH2O)nH;  R2 = 1-6C alkylene;  R3 = H or methyl;  n = 0-20;  R4 = 1-36C alkylene (optionally substituted or unsaturated) or arylene; and  R5 = 2-22C alkyl or alkenyl. Independent claims are also included for the following: (1) Cationic surfactants obtainable by the formation of the addition salts of the alkanolamine esters with mineral or organic acids. (2) Esterquats obtainable by quaternization of the alkanolamine esters with alkylation agents. (3) Aqueous fabric-softening compositions which contain: (a) the surfactants or esterquats, (b) cationic surfactant(s) active as fabric softeners and (c) non-ionic fabric-conditioning surfactant(s). The total amount of (a), (b) and (c) is 2-60 (3-40) wt.% such that, with respect to their total amount: (i) the proportion of component (a) is 2-100 (3-80) wt.%, (ii) the proportion of component (b) is 0-98 (0-97) wt.% and (iii) the proportion of component (c) is 0-40 (0-30) wt.%.
Patent EP-1171244-B1 (EP)
Inventor: HERWIG GERNOT
IPC: B05C13/02
Filed: 2001-01-30
Granted: 2006-08-23
Abstract: A process and apparatus for painting vehicle bodies in which the bodies are moved past at least one paint-applying application device with the aid of a conveyor system, said application device for its part being guided by an application machine, and in which faces of the vehicle body which have different inclinations are painted.
Patent EP-1269326-B1 (EP)
Inventor: HSU JEN-TAI
IPC: G06F13/40
Filed: 2001-03-13
Granted: 2006-06-21
Abstract: An example embodiment of a method and apparatus for reducing back-to-back voltage glitch on a high speed bus is described. A pre-driver circuit receives an input voltage signal whose voltage level swings from a logically low voltage level to a logically high voltage level where the logically low voltage level approximately equals VSS and the logically high voltage level approximately equals VCC. The pre-driver circuit reduces the magnitude of the voltage swing to create a signal that when delivered to a driver transistor ensures that the driver transistor will operate in its saturation region even when the voltage on the high speed bus is at its minimum specified voltage. When the driver transistor operates in its saturation region it can sink a constant current and provide a high output impedance.
Patent EP-1316132-B1 (EP)
Inventor: AISA VALERIO
IPC: H02J3/14
Filed: 2001-04-03
Granted: 2009-01-28
Abstract: A system that monitors at least a household electric user, in particular a household appliance, includes a monitoring device that is connected between a source of electric energy and the electric user, the monitoring device including a metering means for detecting one or more electric quantities being associated with the operation of said user, and further including a control means that is programmed for (i) comparing the electric quantity or quantities being measured through the metering means with reference values of said electric quantity or quantities which are stored within the control means; (ii) generating, in function of the comparison, information being representative of the current operating status or phase of operation of the electric user; and (iii) allowing for the reading or transmission of the information to the outside of said device. The monitoring device also including a communication means, for realizing a transmission and/or reception of data or information on the electric supply line which connects the user to the device, by means of a modulation of electric power between the user and the device and/or vice-versa.
Patent EP-1257591-B1 (EP)
Inventor: OSTROWSKI THOMAS
IPC: B01J27/26
Filed: 2001-02-22
Granted: 2004-05-12
Abstract: Production of polyether polyols comprises use of a multi-metal cyanide complex catalyst in a tall cylindrical reactor having a downward facing spray nozzle in the upper reactor portion, through which the educts and reaction mixture are fed and an outlet, preferably in the lower portion of the reactor to recirculate the reaction mixture via an external circuit and equalizing reservoir. A process for the production of polyether polyols (I) by reaction of diols or polyols with ethylene oxide, propylene oxide and/or butylene oxide in the presence of a multi-metal cyanide complex catalyst (II) comprises carrying out the reaction in a tall cylindrical reactor having a downward facing spray nozzle in the upper reactor portion, through which the educts and reaction mixture are fed, and an outlet, preferably in the lower portion of the reactor, through which the reaction mixture is fed by means of a pump through an external circuit via an equalizing reservoir to the spray nozzle. The external circuit comprises a concentric pipe stretching the entire length of the reactor excluding the reactor ends and contains a heat exchanger integrated within the annulus.
Patent EP-1292418-B1 (EP)
Inventor: NYGAARD EERO
IPC: B23B51/00
Filed: 2001-05-23
Granted: 2007-01-24
Abstract: A drill bit for the working of metal has a center pilot tip that transforms into straight cutting edges extending towards the outer periphery of the bit. Each cutting edge forms a cutting angle of 1-20° with a reference plane oriented perpendicular to of the drill axis. Each a cutting edge is inclined in a radially inward and axially rearward direction toward the drill axis. The center tip forms a pilot point angle of 90±2° and a has base that takes up 23-45 percent of the total diameter of the cutting section of the drill bit. The tip has a tip angle of 90±10°.
Patent EP-1284622-B1 (EP)
Inventor: LOOK JEE LOON
IPC: A61K8/02
Filed: 2001-05-31
Granted: 2010-02-17
Abstract: A multi-composition stick product (10), such as a lip balm, sun screen, deodorant, or glue stick. The multi-composition stick product (10) including a stick composition (14) molded in the container (12) so as to contact the walls thereof and be advanceable or ejected therefrom. The stick composition (14) includes a first composition and a second composition. The first and second compositions differ in at least one component, such as a medicament, colorant, fragrance, flavorant, sunscreen, preservative, conditioner, moisturizer, emollient, or surfactant. Furthermore the first and second compositions are arranged in a predetermined non-random pattern that is reproducible. Also described is the method and apparatus for manufacturing the multi-composition stick product (10).
Patent EP-1272495-B1 (EP)
Inventor: CABRI WALTER
IPC: C07D501/12
Filed: 2001-04-10
Granted: 2004-06-30
Abstract: Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20~40° C.
Patent EP-1274979-B1 (EP)
Inventor: SAEGLITZ MARIO
IPC: B61L23/04
Filed: 2001-04-19
Granted: 2004-01-07
Abstract: The invention relates to a method for monitoring the travelling behavior of rail vehicles, according to which an oscillation behavior of at least one vehicle component is monitored by detecting at least one oscillation pattern and comparing the same with at least one reference oscillation pattern, whereby a natural oscillation of at least one vehicle component is monitored. The invention also relates to a device for monitoring the travelling behavior of rail vehicles, whereby at least one oscillation pick-up is mounted on at least one vehicle component. To this end, means are provided for evaluating the signal pattern, which is supplied by at least one oscillation pick-up, whereby characteristic values of the oscillation patterns of the at least one vehicle component are detected and compared with reference characteristic values of the oscillation patterns of a natural oscillation of the vehicle component.
Patent EP-1295389-B1 (EP)
Inventor: BUCHAILLOT LIONEL
IPC: H03H9/15
Filed: 2001-06-29
Granted: 2007-10-31
Abstract: A nano-electromechanical filter. The filter includes, on a substrate, at least one microtip extended by a beam-shaped nanostructure. The microtip and the nanostructure are at least superficially conductive. The nanostructure forms a resonator. At least one input electrode and at least one output electrode are formed on an insulating layer, on both sides of the axis of the microtip, in the vicinity of the apex of the microtip. The input electrode receives a signal to be filtered and the output electrode provides a filtered signal. The filter can be particularly applied to wireless communications.