baber/WOPTO huggingface dataset:
Patent EP-4010004-A2 (EP)
Title: Compositions and methods for modulation of gene expression
Inventor: URNOV FYODOR
IPC: A61K38/00
Filed: 2020-08-06
Abstract: The present disclosure provides polypeptides, compositions thereof, and methods for suppressing expression of a target gene such as PDCD1, CTLA4, LAG3, or TIM-3. The polypeptides disclosed herein include a DNA binding domain (DBD) that binds to a sequence of the target gene and a transcriptional repressor domain that suppresses expression of the target gene. The transcriptional repressor domain may be a known transcriptional repressor or may be a novel transcriptional repressor disclosed herein. Also disclosed herein are novel transcriptional repressors that are conjugated to a heterologous DNA binding domain and mediate suppression of expression of a target gene bound by the DNA binding domain. Also disclosed herein are split systems for modulating gene expression where the DBD and the functional domain are provided as separated polypeptides and are assembled using dimerization of a heterodimer pair, where the DBD and the functional domain are each fused to a member of the heterodimer pair.
Patent EP-4021953-A2 (EP)
Inventor: LING MIAORU
IPC: C08F265/02
Filed: 2020-08-25
Abstract: La présente invention concerne un matériau absorbant les liquides et son procédé de préparation, un noyau absorbant et un produit absorbant, et appartient au domaine technique des matériaux absorbant les liquides. La présente invention peut résoudre au moins en partie le problème des faibles performances d'absorption de noyaux absorbants existants. Le matériau absorbant les liquides selon la présente invention comprend : une fibre polymère, comprenant une fibre polymère comprenant un matériau polymère pouvant fondre lorsqu'il est chauffé, la fibre polymère ayant été en partie fondue; et une particule absorbante ayant une capacité d'absorption des liquides. Lorsque la fibre polymère se trouve à l'état en partie fondu, la particule absorbante est en contact avec la fibre polymère, ce qui permet de lier la fibre polymère après durcissement de la fibre polymère.
Patent EP-4034549-A2 (EP)
Inventor: LIANG YANBIN
IPC: C07K14/28
Filed: 2020-09-28
Abstract: L'invention concerne des anticorps monospécifiques et multispécifiques à chaîne unique avec des spécificités pour un ou plusieurs parmi CD47, PD-L1, HSA, CD33, LAG3 et CD16.
Patent EP-3945359-A2 (EP)
Inventor: ZESCH WOLFGANG
IPC: G02B27/48
Filed: 2021-07-31
Abstract: Optical device (1) comprising an optical element (10), which is mounted on a carrier (20) by means of a platform (30), 
- the platform (30) comprises a base (32) and an elastic structure (31), wherein 
- the base (32) is connected to the optical element (10), 
- the elastic structure (31) connects the base (32) and the carrier (20), 
- the platform (30) extends along an x-y plane defined by an x-direction (101) and a y-direction (102), 
- an actuator (40) is arranged to apply a force to the base (32) in a direction along the x-y-plane, 
- the elastic structure (32) is elastic in the x-direction (101) and in the y-direction (102), and 
- the base (32) and the elastic structure (31) are fabricated in a one-piece manner.
Patent EP-4011673-A2 (EP)
Inventor: BYUN JAE SUP
IPC: B60K11/08
Filed: 2021-12-08
Abstract: The present disclosure relates to an active air flap apparatus for a vehicle coupled to an air inlet of a grill to cool the inside of an engine room when a vehicle travels, and the active air flap apparatus for a vehicle includes a frame coupled to a rear surface of the grill in which the air inlet is formed, a plurality of flap portions coupled to an inside of the frame to open or close the air inlet and arranged in a vertical direction of the frame, an actuator coupled to an outside of the frame to generate power, a gear unit operated by the power generated from the actuator, and a connection unit connecting the flap portions and the gear unit to each other to operate the flap portions according to the operation of the gear unit.
Patent EP-4088623-A2 (EP)
Inventor: XIAO XIAOHONG
IPC: B62B7/14
Filed: 2021-01-08
Abstract: Provided is a support plate, comprising a plate body and at least one reinforcing member. The plate body is provided with a plurality of through holes, and the reinforcing member is fixed in place with respect to the plate body. The through holes give the support plate enhanced air permeability, and the reinforcing member provides the plate body with increased support strength. Also provided is a carry cot, comprising a frame and the support plate. The support plate is connected to the frame, such that the support plate and the frame together define an accommodating space for accommodating an infant or a toddler. When the infant or the toddler lies in the carrycot, the carrycot provides not only strong support strength but also good air permeability, and is safe and comfortable.
Patent EP-4232519-A2 (EP)
Inventor: OSORIO JAROL
IPC: C09D11/104
Filed: 2021-11-19
Abstract: The present invention provides a two part ink or coating system, wherein Part A comprises one or more hydroxyl functional resins, one or more aminoplast crosslinkers, one or more polyester polyols, and one or more solvents; and Part B comprises an acid catalyst. Part A and Part B are combined just prior to application on a substrate. The ink or coating system of the invention is resistant to removal from polyolefin film substrates when subjected to a hot caustic wash. When applied as an overcoat (backing coat) over conventional inks printed on polyolefin film substrates, the ink or coating system of the invention also prevents removal of the conventional inks from the polyolefin substrate when subjected to a hot caustic wash. Advantageously, use of the ink and coating systems of the present invention reduces ink staining and contamination of recycled PET flakes.
Patent EP-4213191-A2 (EP)
Inventor: STOLZE KAROLINE
IPC: H01L21/683
Filed: 2023-01-11
Abstract: Die Erfindung betrifft ein Verfahren zum Herstellen einer Halbleiterstruktur umfassend ein Zielsubstrat und wenigstens ein auf dem Zielsubstrat angeordnetes Halbleiterstück, das vorzugsweise ein III-V-Halbleiterstück ist. Das Verfahren weist die Schritte auf:- Fixieren eines einkristallinen Halbleiterplättchens, insbesondere eines III-V-Halbleiterplättchens, auf einem Trägersubstrat (604) mittels einer Haftschicht (602),- Herstellen von wenigstens einem Halbleiterstück (614) aus dem Halbleiterplättchen, wobei das Halbleiterstück mittels der Haftschicht auf dem Trägersubstrat fixiert bleibt,- Lösen des wenigstens einen Halbleiterstücks von der Haftschicht und dem Trägersubstrat mit einer Transfervorrichtung, und- Aufbringen des Halbleiterstücks auf das Zielsubstrat mit der Transfervorrichtung.
Patent EP-4218538-A2 (EP)
Title: Cleaning adapter with and without safety tag
Inventor: HERNANDEZ CESAR E
IPC: A61B1/12
Filed: 2019-05-06
Abstract: A cleaning adapter for an endoscope is provided. The cleaning adapter comprises a main stem comprising a first through hole extending transversely through the main stem, a second through hole extending transversely through the main stem, and a channel within the main stem fluidly coupling the first through hole to the second through hole. In some embodiments, a tag for an endoscope valve is provided. Methods and kits are also provided.
Patent EP-4289996-A2 (EP)
IPC: C40B40/06
Filed: 2018-11-05
Abstract: Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.
Patent EP-4290253-A2 (EP)
Inventor: EIBL MARKUS
IPC: G01R31/28
Filed: 2021-04-21
Abstract: Eine Temperiervorrichtung (1) zum Temperieren eines Probertisches (110) für Halbleiterwafer und/oder Hybride weist einen Fluideingang (10) zum Einleiten eines Temperierfluids in die Temperiervorrichtung (1) auf und zumindest einen Wärmetauscher (20; 30) zum Temperieren des Temperierfluids. Ein Kühlbooster (70) ist zum Temperieren des Temperierfluids konfiguriert. Durch eine Probertemperierleitung (40) ist das temperierte Temperierfluid zum Probertisch (110) leitbar. Eine Eingangsfluidschaltung (80) ist dazu konfiguriert, das eingeleitete Temperierfluid auf ein Einführschaltsignal hin wahlweise entweder durch den zumindest einen Wärmetauscher (20; 30) oder durch den Kühlbooster (70) in die Probertemperierleitung (40) zu leiten.
Patent EP-4306742-A2 (EP)
Inventor: PICCONE FRANCO
IPC: E04F13/04
Filed: 2018-11-09
Abstract: A stay-in-place concrete formwork system allows stucco to be applied directly to the formwork, avoiding the need to provide a further surface treatment of the wall prior to applying stucco. Apertures are provided on an exterior facing wall of the formwork panel to receive and embed stucco therein. The panel may also be formed with outward stucco-engaging projections. Other features include using rigid insulation to brace the stucco and keep concrete from the apertures, a sealing joint element, extendible panels for use in curved formwork, rainscreen features and an alligator connector panel for adjustable lengths of formwork faces.
Patent EP-0001311-A2 (EP)
Inventor: SPRITZER GELMAN STEPHANIE
IPC: B65D33/01
Filed: 1978-09-19
Abstract: An improved microwave energy moderating bag for enclosing, for instance, foodstuff such as a beef roast to be cooked at relatively high power in a microwave oven so that the foodstuff can be uniformly cooked to a predetermined degree of doneness without being repositioned and without having to vary the power level during the cooking interval. The improved bag is of the type fabricated from a laminated sheet comprising two laminae of thermoplastic films and a perforated foil lamina of microwave reflective material such as, for example, aluminum foil. The improved bag comprises an improved pouch-type closure and duplex side seams. Both static and dynamic embodiments of the invention are disclosed: a static embodiment being dimensionally stable as opposed to a dynamic embodiment which is heat shrinkable by virtue of comprising a heat shrinkable thermoplastic film. Such a dynamic embodiment is so constructed that it transitions from being substantially transparent to microwave energy to being substantially less transparent to microwave energy as its temperature is increased: for instance, during a cooking cycle in a microwave oven.
Patent EP-0012821-A2 (EP)
Inventor: KENNEDY EUGENE THOMAS
IPC: B41J2/17
Filed: 1979-11-08
Abstract: A system and method are disclosed for analyzing operation of the ink jet head of an ink jet printer. Initiation of start-up is sensed, as is the pressure build-up in the ink jet head as ink is supplied thereto. The time lapse between initiation of start-up and the commencement of pressure build-up is determined, as is the time required forthe pressure within the ink jet head to build to an operational level, and outputs indicative thereof are utilized for determination of fault occurrence and indication of faults or initiation of fault correction in response thereto. The system includes a pair of counters 33, 35. Counter 33 is controlled by a start-up initiation signal via gate 29 and the output of a comparator 39 which receive a predetermined reference signal 1 and a signal indicative of pressure build-up at the ink jet head. Counter33 thus reaches a count indicative of the time taken for the ink pressure to reach the first reference pressure. Counter35 similarly provides a count indicative of the time taken for the ink pressure to change from the first to the second reference pressure. The outputs of counters 33, 35 or gated to microprocessor 25 where they are analyzed to determine whether the printer is operating correctly or whether maintainance or repair is required.
Patent EP-0013577-A2 (EP)
Inventor: BROADHURST MICHAEL JOHN
IPC: C07C46/00
Filed: 1980-01-15
Abstract: Cyclic compounds of the general formula 
<CHEM>
 wherein one of R<1> and R<2> is hydrogen and the other is hydrogen or hydroxy or R<1> and R<2> taken together are a protected oxo group; R<3> is hydrogen, hydroxy or acyloxy; R<4> is lower alkyl, esterified carboxy or a group of the formula -C(R<5>, R<6>) -CH2-X; R<5> and R<6> taken together are oxo or protected oxo; X is hydrogen, hydroxy, acyloxy or -(CH2)n-OY; Y is hydrogen, alkyl or acyl and n is 1 or 2; with the proviso that one of R<1> and R<2> is hydrogen and the other is hydroxy or R<1> and R<2> taken together are protected oxo when R<3> is acetoxy and R<4> is acetyl;
 processes for the preparation thereof and intermediates in these processes.
Patent EP-0021318-A2 (EP)
Inventor: JESPERSEN PAUL W
IPC: A47K10/36
Filed: 1980-06-18
Abstract: Dispensing flexible sheet material involves mounting at least one roll R on dispensing arm means 48 pivotally connected at 54 to a dispenser 12 near the lower end of the chassis so that as material on the roll is depleted the concomitant diminishing diameter roll R will swing down on the dispensing arm means 48 for the roll axis to move through an arc spaced from the axis of the feed roller 24 to wedge the roll surface firmly against the surface of a feed roller as the axis of the roll R moves toward a line extending through the feed roller axis and the pivotal axis where the dispensing arm means 48 is connected to the chassis. When the roll R is essentially depleted it swings past the line and the feed roller 24 into a discard area 60. Dispensing from multiple rolls in succession utilizes an initial roll R mounted as above described and a reserve arm means 66 connected to the chassis through means 76 which permits the reserve arm means 66 to move down vertically relative to the chassis as the initial roll R is depleted to a lower position where the reserve arm means 66 thereupon pivots relative to the chassis and the reserve roll RR engages with the feed roller 24 when the essentially depleted initial roll R swings into the discard area 60 to swing through an arc similar to that which the initial roll R moved through as its diameter diminished.
Patent EP-0025850-A2 (EP)
Inventor: FIELDHOUSE JOHN WILLIAM
IPC: C01B21/098
Filed: 1980-08-08
Abstract: Linear polydihalophosphazene polymers which are substantially free of gel are prepared by thermally polymerizing a cyclic polyhalophosphazene represented by the formula (NPX 2 ) 3 , wherein X is fluorine, chlorine or bromine in the presence of a catalyst which comprises the reaction product of a boron trihalide compound with an oxygenated phosphorus compound. 
     In addition to producing substantially gel free polymers, the catalyst composition of the process of the invention permits improved control of molecular weight, lower polymerization temperature, high rates of conversion of (NPCl 2 ), to (NPCl 2 ) n , and provides for more readily processible and derivatizable polymers.
Patent EP-0042068-A2 (EP)
Inventor: SCHMIDT HELMUT DIPL-ING
IPC: F16F1/366
Filed: 1981-05-15
Abstract: Eine Ringfeder zur Belastungsaufnahme in der Ringebene, die auch gute Dämpfungseigenschaften aufweist und für hohe Belastungen geeignet ist, ist gekennzeichnet durch den Aufbau als Wickelkörper und mit Lagen von faserverstärktem Kunststoff.
Patent EP-0067238-A2 (EP)
Inventor: WINSTEAD THOMAS W
IPC: B29C51/18
Filed: 1981-06-13
Abstract: method and apparatus for continuously extruding, biaxially orienting and intermittently forming molded products from a web of thermoplastic material and further, continuously separating the products from the web selvage, stacking and handling the products and recycling the web selvage for further extrusion. The method and apparatus use intermittent molding and biaxial orientation devices into which configuration the continuously extruded web is interfaced by continuous-to-intermittent interfacing loop arrangement which preserves the dimensional and orientational integrity of the web and maintains sufficient thermal stability therein to provide molded products which are free from defects such as stretch marks and other inertial and thermal discontinuities normally anticipated in cases of intermittent web advance of thermoplastic material at thermoformable temperature levels.
Patent EP-0047480-A2 (EP)
Inventor: THIBODEAU LISE
IPC: A61P31/12
Filed: 1981-09-02
Abstract: Current virus vaccines made of inactivated particles often induce undesirable local and general secondary reactions. Therefore there is a need for a vaccine that would not contain the substances responsible for these side effects. An immunosome has been constructed, highly immunogenic, which is exclusively made of the antigens attached onto the membrane of a preformed liposome. This immunosome is prepared by providing a quantity of preformed liposomes; providing an antigen viral sub-unit-detergent complex; treating the preformed liposomes to enable antigen sub-units to anchor onto the liposomes so as to form projections on the outer surface of said liposomes; and combining said antigen viral sub-unit-detergent complex with the liposomes obtained above so as to give said immunosomes. This technique recreates a structure that is almost undistinguishable from the virus particle. This immunosome is more immunogenic than the subunits used for its preparation.
Patent EP-0058797-A2 (EP)
Inventor: DICKEY JOE BEN
IPC: F28F25/08
Filed: 1981-11-05
Abstract: An improved, high efficiency, combination fill assembly (26) for crossflow cooling towers is provided which employs a strategically located, multiple sheet film fill section (28) in conjunction with splash-type fill (30) to maximize tower performance with a minimum tower height, pumping head requirements, and pressure drop across the assembly. In preferred forms, the fill includes a film fill section presenting substantially separate air and water entrance (52, 48) and exit faces (54, 50), along with structure (56) above the upper water entrance face (48) thereof for dispersing water and inhibiting exiting of cooling air out of the water entrance face (48); in this fashion «short circuiting» of cooling air is inhibited, and the inertia of airflow is thereby maintained in the desirable crossflowing direction for enhanced water cooling. Separate film packs (32-40) cooperatively define the overall film fill section, and the packs (32-40) are advantageously arranged in an inwardly staggered relationship, with the uppermost pack being outermost, i.e., closest to the air entrance of the fill assembly. Splash fill (30) is employed in the regions of the overall assembly free of film fill packs.
Patent EP-0044803-A2 (EP)
Inventor: SUESSKIND EGON
IPC: B23K35/22
Filed: 1981-06-29
Abstract: The invention relates to a method of assembling a printed circuit board with components in which the conductor paths are printed using a solder resist, the components are inserted and soldered, and subsequently the side which is free of components is covered with an insulating varnish coating. In order to be able to carry out the method comparatively simply, and to achieve a high dielectric strength between the conductor paths, a further printing of the conductor paths (2) is carried with the solder resist rather than covering the board with the insulating varnish coating. The method is suitable for the production of any printed circuit boards (figure 1).   <IMAGE>
Patent EP-0035003-A2 (EP)
Inventor: BRUTTI MARIO
IPC: D05B15/02
Filed: 1981-02-09
Abstract: The machine in question is for stitching the upper border of the tubular type of moccasin where the shoe upper 2 is folded back externally over the vamp 1 and is stitched with both initially extending in one plane, and it comprises a needle 10-first presser foot 13 ensemble, movable perpendicularly to the parts to be stitiched and parallel therewith, the infeed motion corresponding to the length of one stitch, a second presser foot 14 placed downstream of the previously mentioned ensemble with respect to the infeed motion, movable perpendicularly to the parts to be stitched, for the locking thereof, a ruffler presser foot 15, positioned upstream of the said ensemble, movable perpendicularly to the parts to be stitched and parallel therewith, designed to ruffle the vamp jointly with a separator member 16 fixed to the frame; the machine also comprises a device 18 forfolding the shoe upper back over the vamp, constituted by a disc on a horizontal shaft, perpendicular to the said parts to be stitched, and placed above the said ruffler presser foot 15, acting in unison therewith.
Patent EP-0062314-A2 (EP)
Inventor: YAMAZAKI TAKEO
IPC: H01C7/10
Filed: 1982-04-01
Abstract: A non-linear resistor having each continuous film havin no gas permeability and lower electrical resistivity than the resistivity of a sintered body between the sintered body having non-linear resistance characteristics and an electrode, has excellent stability for application of rated voltage for a long period of time.
Patent EP-0071716-A2 (EP)
Inventor: OTT GRANVILLE E
IPC: G10L15/02
Filed: 1982-06-14
Abstract: An allophone vocoder which utilizes the inherent redundancy of the spoken language together with the automatic human filtering of speech so as to obtain a speech compression and recognition system. An analog speech signal is broken up into its phoneme components (105) and encoded for transmission (110). The encoded phoneme sequence has a much higher compression rate than the analog speech signal. The phonemes are then either transmitted (110), stored (109), or used to generate directly an analogous allophone sequence (114) so as to approximate the original speech signal. Due to the inherent redundancy of the spoken language, and the filtering effect of the human, variations or errors in the approximations of the phonemes received from the original speech signal are inconsequential to the comprehension ability of the final allophone synthesized speech.
Patent EP-0071347-A2 (EP)
Inventor: THALER WARREN ALAN
IPC: C08F12/04
Filed: 1982-07-01
Abstract: A process for forming a sulfonated aromatic polymer includes the forming of a cement of the aromatic polymer in a hydrocarbon solvent and then contacting of the cement of the aromatic polymer with a sulfonating agent for a sufficient period of time at a sufficient temperature to form a sulfonated aromatic polymer having at least about 0.3% sulfur incorporated therein, wherein the sulfonating agent is hydrogencarbon soluble and is formed in a hydrocarbon solvent by the reaction of S0 3  with a carboxylic acid having at least about 8 carbon atoms.
Patent EP-0093414-A2 (EP)
Inventor: PECHE GERHARD DR DIPL-ING
IPC: H01H33/66
Filed: 1983-04-28
Abstract: In einer Vakuumschaltröhre mit zueinander fluchtenden Kontakten (10, 11), von denen ein Kontakt über einen Stehbolzen (9) als fester Kontakt (10) mit dem Gehäuse mechanisch fest verbunden ist, wird die Verbindung zwischen dem Stehbolzen (9) und dem Gehäuse über einen elastischen Flansch (8) hergestellt, wobei dieser elastische Flansch (8) einen in axialer Richtung elastisch leicht verformbaren Ring (3) enthält, welcher durch eine Zylinderwand (2) von einem Lötflansch (1) getrennt ist. Dadurch wird eine gegenseitige seitliche Verschiebung der Kontakte (10, 11) infolge der beim Stromdurchgang auftretenden mechanischen Kräfte ermöglicht, ohne daß dadurch das kraftschlüssig mit den Kontakten (10, 11) verbundene Gehäuse zerbricht. Die Erfindung eignet sich insbesondere für Vakuumleistungsschaltröhren für sehr hohe Einschaltströme.