Patent SG-11201408651T-A (SG)
Title: Use of markers in the diagnosis and treatment of prostate cancer
Inventor: NARAIN NIVEN RAJIN
IPC: C12Q1/68
Filed: 2013-06-27
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/004931 A1 (51) International Patent Classification: C12Q 1/68 (2006.01) G01N33/68 (2006.01) G01N 33/574 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/665,201 61/672,090 61/673,094 61/702,523 61/718,080 61/718,081 61/718,064 27 June 2012 (27.06.2012) 16 July 2012 (16.07.2012) 18 July 2012 (18.07.2012) 18 September 2012 (18.09.2012) 24 October 2012 (24.10.2012) 24 October 2012 (24.10.2012) 24 October 2012 (24.10.2012) PCT/US2013/048373 27 June 2013 (27.06.2013) English English US US us us us us us (71) Applicant: BERG PHARMA LLC [US/US]; 1845 Elm Hill Pike, Nashville, TN 37210 (US). (72) Inventors: NARAIN, Niven Rajin; 73 Fresh Pond Park­ way, Cambridge, MA 02138 (US). SARANGARAJAN, Rangaprasad; 454 Central Street, Boylston, MA 01505 (US). VISHNUDAS, Vivek K.; 91 Stamford Street, Apt. #1, Newton, MA 02466 (US). (74) Agents: HANLEY, Elizabeth A. et al.; McCarter & Eng­ lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, [Continued on next page] (54) Title: USE OF MARKERS IN THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER FIG. 7 10000 \"• .g 1000 c o o OJ •I OJ >- 0\ •t o o 100 10 Mean LY9 Levels in Human Serum n=2 p=0.225 • J A A • • • ~T W~ vT ' • ' ^• T (57) Abstract: The invention provides method for diagnosis, monitoring, and pro­ gnosis of prostate cancer using one or more of keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9, and PSA. The inven­ tion provides kits for practicing the meth­ ods of the invention. Prostate Cancer Normal Donors o CJ o & wo 2014/004931 AI III llll IIII III III Hill III III III Hill Hill lllll II llll 111 lllllll llll 111 llll TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))