Patent SG-11201808671Y-A (SG)
Title: Porous silicon microparticle-based cancer vaccines and methods for potentiating anti-tumoral immunity
Inventor: SHEN HAIFA
IPC: A61K39/12
Filed: 2016-04-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111111111101101010111110111011011011111111111111111111110111111111111001111 International Bureau ... .... ..Yjd ..... .....!;,„./ (10) International Publication Number (43) International Publication Date WO 2016/161391 A3 6 October 2016 (06.10.2016) WIPO I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 39/00 (2006.01) A61K 47/48 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A61K 39/12 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, PCT/US2016/025757 MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (22) International Filing Date: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 1 April 2016 (01.04.2016) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/142,278 2 April 2015 (02.04.2015) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: THE METHODIST HOSPITAL [US/US]; DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 6565 Fannin, MS D-200, Houston, Texas 77030 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: SHEN, Haifa; 4313 Cynthia Street, Bellaire, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Texas 77401 (US). MA, Xiaojun; 2610 Salado Drive, GW, KM, ML, MR, NE, SN, TD, TG). Pearland, Texas 77584 (US). FERRARI, Mauro; 16 West Published: Oak Dr., #C, Houston, Texas 77056 (US). — with international search report (Art. 21(3)) (74) Agent: MOORE, Mark D.; Haynes and Boone, LLP, before the expiration of the time limit for amending the 2323 Victory Avenue, Suite 700, Dallas, Texas 75219 claims and to be republished in the event of receipt of (US). amendments (Rule 48.2(h)) (81) Designated States (unless otherwise indicated, for every _ with sequence listing part of description (Rule 5.2(a)) kind of national protection available): AE, AG, AL, AM, [Continued on next page] (54) Title: POROUS SILICON MICROPARTICLE-BASED CANCER VACCINES AND METHODS FOR POTENTIATING AN- = TI-TUMORAL IMMUNITY (57) : Porous silicon (pSi) microparticles CD8T cell activation (PSM) are disclosed, which provide an important ad- 000 E el, 800 - 2 600- 12 4E a3 400- 0 0 200- cm ,.. n fri C''''l r ---- ] ri vance in the area of cancer immunotherapeutics and mo- lecular nanomedicine. In particular, potent PSM-based adjuvants are disclosed for dendritic cell-based vaccines compositions, and methods for their use in a variety of cancer immunotherapies. The PSM of the present inven- tion are also useful in developing other types of vac - cines, including those not necessarily related to the treatment of cancers, such as vaccines for the treatment of acne, Alzheimer's disease, asthma, atherosclerosis, autoimmune disorders, autoinflammatory disease, celiac disease, colitis, Crohn's disease, diabetes, glomer- ulonephritis, infectious diseases, inflammatory bowel i I , 1 1 , 1 - . : ., , C < < 5 < < < < 5 5 \". disease, irritable bowel syndrome, ischemia, Lupus, pel- -... > > ...... > > > > > ..... 1--- 00 pc) ocn oa cc , cp vic inflammatory disease, reperfusion injury, rheumat- ED: + - { - 5 + + + '''• + + + old arthritis, sarcoidosis, transplant rejection, and re- en 7 CL El. cz CL CL cn 0 0- 0- .4 n -I CL n M Cl. CI M < .., « C-) « lated illnesses. CD OCDCD .---- C-DLD 11 -( 1 )- —I - 0 )- -7- T. g 7 -- cn C-7 .2- Ca cn CD M U 0- 11 0 V; ---- 0. _i CID 11 ...... FIG. 17 ,—, © N O WO 2016/161391 A3 MIDEDIMOMOIDERMIEEDEMIEM11111 101111111011111110 MI IIIIIIII (88) Date of publication of the international search report: 29 December 2016