Patent EA-000976-B1 (EA)
Title: Composition for treating pain and method therefor
Inventor: SHANNON HARLAN E
IPC: A61K31/55
Filed: 1997-03-24
Abstract: 1. A composition for treating pain comprising olanzapine or a pharmaceutically acceptable salt or solvate thereof; and one or more drug useful in the treatment of pain in a weight ratio of from about one part olanzapine to from about one (1) part to about one thousand (1000) parts drug useful in the treatment of pain. 2. A composition of claim 1 wherein the drug useful in the treatment of pain is an NSAIDS. 3. A composition of claim 2 wherein the NSAIDS is selected from the group consisting of aspirin, indomethacin, ibuprofen, naproxen, fenoprofen, tolmetin, sulindac, meclofenamate, keoprofen, piroxicam, flurbiprofen, and diclofenac or a pharmaceutically acceptable salt thereof. 4. A composition of claim 1 wherein olanzapine is Form II olanzapine polymorph having a typical x-ray diffraction pattern as follows, wherein d represents the interplanar spacing: d 10.2689 8.577 7.4721 7.125 6.1459 6.071 5.4849 5.2181 5.1251 4.9874 4.7665 4.7158 4.4787 4.3307 4.2294 4.141 3.9873 3.7206 3.5645 3.5366 3.3828 3.2516 3.134 3.0848 3.0638 3.0111 2.8739 2.8102 2.7217 2.6432 2. 6007 5. A composition of claim 4 wherein the drug useful in the treatment of pain is selected from the group consisting of aspirin, ibuprofen, and naproxen. 6. A composition of claim 1 wherein the weight ratio of olanzapine to drug useful in the treatment of pain is from about one part olanzapine to from about one (1) to about one hundred (100) parts drug useful in the treatment of pain. 7. A composition of claim 6 wherein the weight ratio is from about one part olanzapine to from about one (1) to about thirty (30) parts drug useful in the treatment of pain. 8. A composition of claim 7 wherein the weight ratio is from about one part olanzapine to from about one (1) to about ten (10) parts drug useful in the treatment of pain. 9. A composition of claim 8 wherein the drug useful in the treatment of pain is selected from the group consisting of morphine, acetaminophen, ibuprofen, and diclofenac. 10. A composition of claim 1 wherein the drug useful in the treatment of pain is an opioid compound. 11. A composition of claim 4 wherein the drug useful in the treatment of pain is an opioid compound. 12. A composition of claim 7 wherein the drug useful in the treatment of pain is an opioid compound. 13. A composition of claim 10 wherein the opioid compound is selected from the group consisting of morphine, codeine, meperidine, methadone, propoxyphene, levorphanol, hydromorphone, oxymorphone, oxycodone, brompton's cocktail, pentazocine, butorphanol, nabuphine, and buprenorphine. 14. A composition of claim 13 wherein the opioid compound is selected from the group consisting of morphine, oxymorphine, oxycodone, hydromorphine, codeine, and methadone. 15. A composition of claim 1 wherein the drug useful in the treatment of pain is selected from the group consisting of tylenol  [not equal]  3, tricyclic antidepressants (for example desipramine, imipramine, amytriptiline, nortriptiline), anticonvulsants (for example, carbamazepine, gatapentine, valproate), and serotonin reuptake inhibitors (for example, fluoxetine, paroxetine, citalopram, sertraline), mixed serotonin-norepinephrine reuptake inhibitors (for example venlafaxine, duloxetine), serotonin receptor agonists and antagonists, cholinergic (muscarinic and nicotinic) analgesics, and neurokinin antagonists. 16. A composition of claim 4 wherein the drug useful in the treatment of pain is selected from the group consisting of tylenol  [not equal]  3, tricyclic antidepressants, anticonvulsants, and serotonin reuptake inhibitors, mixed serotonin-norepinephrine reuptake inhibitors analgesics, and neurokinin antagonists. 17. A composition of claim 16 wherein the drug useful in the treatment of pain is a tricyclic antidepressant. 18. A composition of claim 1 wherein the drug useful in the treatment of pain is an alpha adrenergic compound. 19. A composition of claim 18 central alpha adrenergic active compound is clonidine or a pharmaceutically acceptable salt thereof. 20. A composition of claim 4 wherein the drug useful in the treatment of pain is an alpha adrenergic compound. 21. A composition of claim 7 wherein the drug useful in the treatment of pain is an alpha adrenergic compound. 22. A method for treating pain comprising administering an analgesic dose of a composition comprising olanzapine or a pharmaceutically acceptable salt or solvate thereof;and one or more drug useful in the treatment of pain in a weight ratio of olanzapine to drug useful in the treatment of pain of from about one part olanzapine to from about one (1) to about one thousand (1000) parts drug useful in the treatment of pain. 23. A method of claim 22 wherein the drug useful in the treatment of pain is an NSAIDS. 24. A method of claim 22 wherein the weight ratio of olanzapine to drug useful in the treatment of pain is from about one (1) part olanzapine to from about one (1) to about one hundred (100) parts drug useful in the treatment of pain. 25. A method of claim 24 wherein the weight ratio of olanzapine to drug useful in the treatment of pain is from about one (1) part olanzapine to from about one (1) to about thirty (30) parts drug useful in the treatment of pain. 26. A method of claim 22 wherein olanzapine is Form II olanzapine polymorph having a typical x-ray diffraction pattern as follows, wherein d represents the interplanar spacing: d 10.2689 8.577 7.4721 7.125 6.1459 6.071 5.4849 5.2181 5.1251 4.9874 4.7665 4.7158 4.4787 4.3307 4.2294 4.141 3.9873 3.7206 3.5645 3.5366 3.3828 3.2516 3.134 3.0848 3.0638 3.0111 2.8739 2.8102 2.7217 2.6432 2. 6007 27. A method of claim 22 wherein the drug useful in the treatment of pain is selected from the group consisting of alpha adrenergic compounds and opioid compounds. 28. A method of claim 22 wherein the drug useful in the treatment of pain is selected from the group consisting of tylenol  [not equal]  3, tricyclic antidepressants, anticonvulsants, and serotonin reuptake inhibitors, mixed serotonin-norepinephrine reuptake inhibitors analgesics, and neurokinin antagonists. 29. A method of claim 22 wherein pain is neuropathic pain. 30. A method of claim 22 wherein pain is nociceptive pain. 31. A method of claim 22 wherein the pain is acute pain.