baber/WOPTO huggingface dataset:
Patent BG-103432-A (BG)
Title: Derivatives of 1,4-diazabicyclo[2.2.2]oct-2-ylmethylbenzoate, method for their preparation and application in therapy
Inventor: LOCHEAD ALISTAIR
IPC: A61P25/06
Filed: 1999-05-26
Abstract: The compounds are ligands of the serotoninergetic receptors of the types 5-HT3 and/or 5-HT4 and act as 5-HT4 agonists and/or 5-HT5 antagonists. The have the general formula where R1 means methyl group, X1 means hydrogen atom or OR1 and X1 together form a group with the formula -O(CH2)2-, -O(CH2)3-, O(CH2)20- or -O(CH2)30-; X2 is hydrogen atom or aminogroup, and X3 is halogen atom. 4 claims
Patent BG-105261-A (BG)
Title: Panel form acoustic apparatus using bending waves oscilations
Inventor: AZIMA HENRY
IPC: H04R7/04
Filed: 2001-02-16
Abstract: The acoustic member has panel form capable of supporting wave vibration and has bending wave velocity varied in the region of coincidence to provide a range of coincidence frequencies, thus ensuring a range of coincidence frequencies for causing acoustic coupling of the bending waves in the panel to occur over a broader range of angles for making the coupling more uniform. The member may be incorporated in a loudspeaker having a panel member (1) and exciter (3) fixed to member (1) for exciting bending waves to cause an acoustic output. Electric conductors (5) connect the exciter (3) to an amplifier. The panel member (1) is made of a core (7) and two sheathings (9), and it also can be monolith. 29 claims, 24 figures
Patent BG-106083-A (BG)
Title: Substituted bicyclic heteroaryl compounds as integrin antagonists
Inventor: KLARK DAVID E
IPC: A61P35/00
Filed: 2001-11-05
Abstract: The invention is directed to physiologically active compounds of general formula R1Z1-Het-L1-Ar1-L2-Y wherein Het is an optionally substituted, saturated, partially or fully unsaturated 8 to 10 member bicyclic ring containing at least one heteroatom selected from O, S or N; R1 is optionally substituted aryl, heteroaryl, alkyl, alkenyl, cycloalkyl or heterocycloalkyl; Z1 represents a direct bond, an alkylene chain, NR4, O or S(O)n; L1 is an a -R5-R6 linkage, where R5 is alkylene, alkenylene or alkynylene and R6 is a direct bond, cycloalkylene, heterocycloalkylene, arylene, heteroaryldiyl, -C(=Z3)-NR4-, -NR4-C(=Z3)-, -Z3-, -C(=O)-, -C(=NOR4)-, -NR4-, -NR4-C(=Z3)-NR4-, -SO2-NR4-, -NR4-SO2-, -O-C(=O)-, -C(=O)-O-, -NR4-C(=O)-O- or -O-C(=O)-NR4; L2 is a direct bond; an optionally substituted alkylene, alkenylene, alkynylene, cycloalkenylene, cycloalkylene, heteroaryldiyl, heterocycloalkylene or arylene linkage; a -[C(=O)-N(R9)-C-(R4) (R10)]p-linkage; a -Z4-R11-linkage; a -C(=O)-CH2-C-(=O) linkage, a -R11-Z4-R11-linkage; or -L3-L4-L5-linkage; and Y is carboxy or an acid bioisostere; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e. g. hydrates) of such compounds and their N-oxides and prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (alpha4beta1). 31 claims
Patent CN-1263313-A (CN)
Title: 输出树结构间差分的方法及其装置
Inventor: KEIJO TORIGOE
IPC: G06F17/30
Filed: 2000-02-12
Abstract: 一种树结构数据编辑装置包括:输出单元,数据库(1,2),差分树结构数据产生单元(3)和输出控制单元(5)。数据库储存第一和第二树结构数据,它们分别具有分层的第一和第二树结构。差分树结构数据产生单元为每一树节点比较第一和第二树结构数据,并产生分层表示第一和第二树结构数据间差分的差分树结构数据。输出控制单元分析差分树结构数据,并控制输出单元以根据分析的结果输出第一和第二树结构数据之间的差分输出。
Patent CN-1287177-A (CN)
Title: 筛选基因变异和蛋白质结合的dna片段的方法
Inventor: LIU JIANHUA
IPC: C12Q1/68
Filed: 2000-06-15
Abstract: 本发明主要包括制备DNA片段、检测与蛋白质结合的DNA片段和鉴定基因变异的方法。检测蛋白质结合DNA片段的方法:基因组DNA用内切酶酶切或用引物进行的PCR扩增制备出片段,用基团修饰这些DNA片段的末端,使与相应的固相载体表面进行共价交联,用微阵列点样设备将各种DNA片段点样子固相载体表面并共价交联之,制备成DNA芯片,用这种DNA芯片筛选蛋白质结合的DNA片段的方法。
Patent CN-1387634-A (CN)
Title: 确保暗盒指示器处于驻留位置的aps照相机
Inventor: ZAWODNY ARTHUR
IPC: G03B17/28
Filed: 2000-09-15
Abstract: 本发明的照相机包括一个定位机构(46),它能保证在从照相机中取出胶卷暗盒前,APS胶卷暗盒的可见曝光指示器处于驻留位置。照相机可以包括一个可旋转的轮(50),它旋转以在胶卷暗盒隔舱之间移动胶卷,一个胶卷曝光区和一个胶卷轴。在一个优选实施例中,定位机构包含一个销(62),在胶卷被卷回胶卷暗盒后,它接合可旋转的轮,并且轮被旋转了足够的角度以保证可见曝光指示器移动到驻留位置。当销接合可旋转的轮时,销阻止了可旋转轮的进一步转动。这对照相机使用者指明可见曝光指示器处于驻留位置。
Patent CN-1368375-A (CN)
Title: 用于治疗骨质疏松症的药物组合物
Inventor: CHEN XING
IPC: A61P19/10
Filed: 2001-02-06
Abstract: 本发明涉及的用于治疗骨质疏松症的药物组合物,以天然药用原料补骨脂、牛膝和淫羊藿的提取物为有效药用成分,和制药中允许使用的辅助添加性成分组成,各有效药用组分提取物以相当于其提取所用的原料生药重量表示的重量组成为:补骨脂1,牛膝2－20,淫羊藿2－20,辅助添加性成分0－3。
Patent CN-1442033-A (CN)
Title: 印制电路板的emi和rfi屏蔽
Inventor: ORTIZ JESUS AL
IPC: H01R13/6599
Filed: 2001-03-28
Abstract: 本发明提供一种真空沉积金属层(36)，它能够屏蔽PCB或FPC(20)中的电子元件(40)。真空金属化导电层(36)能够连接到电路板上的地线(32)，以形成法拉第屏蔽罩，以保护设置在电路板中的电子元件(40)不受EMI影响。该金属化导电层能够设置在封装绝缘层(30)之上，或者设置在与PCB或FPC结合的已成形的热成形件或者注模塑料基片之上。
Patent CN-1394868-A (CN)
Title: 一种从南昌链霉菌发酵液中提取梅岭霉素的改进方法
Inventor: ZHANG SILIANG
IPC: C07H17/08
Filed: 2002-07-04
Abstract: 本发明公开了一种从南昌链霉菌发酵液中提取梅岭霉素的改进方法，该法主要包括发酵液的预处理工艺、液固分离工艺、残留在滤液中梅岭霉素的萃取回收工艺、滤饼(菌丝体)的预处理工艺、菌丝体的一步溶媒浸提与浸提液的浓缩工艺，以及浓缩浸提液的一步萃取工艺等。梅岭霉素的总回收率(以发酵液中梅岭霉素总含量为基准)可达85％以上。
Patent CN-1522119-A (CN)
Inventor: NISHIDA MINORU
IPC: A23L19/18
Filed: 2002-05-30
Abstract: 进行油炸的油层的油面面积SA与从油底到油面的高度HA在满足HA/SA －2 ＝0.6～3.5这一关系的条件下，在油层中对材料进行油炸。
Patent CN-1526127-A (CN)
Inventor: PACKARD RONALD
IPC: G09B7/00
Filed: 2002-05-09
Abstract: 一种虚拟教学的系统和方法，提供基于因特网的小学和中学，负责向所有学生提供完整的和可充分理解的教育。该系统和方法中使用的课程是遍布的Web和被驱动的数据库。其科目包括但不限于历史/公民/地理，语言艺术，数学，音乐，科学，和视觉艺术，课文最好为成熟的教学经验集成在线和离线指导资料。
Patent CN-1589466-A (CN)
Title: 音频编码
Inventor: DE KERKHOF LEON M VAN
IPC: G10L19/012
Filed: 2002-11-22
Abstract: 利用多声道音频编码系统中的源对一组具有相关分量的音频信号进行编码的方法。该方法包括根据所述音频信号之间的相关性来确定所述源的组合的步骤，在所述的组合中的源基本不相关，使得源的所述组合以保留相关性的方式合成所述分量。该方法还包括通过为每个源确定一组用于合成所述源的参数和一组用于产生源的所述组合的变换参数来对这些源进行编码的步骤。
Patent CN-1552209-A (CN)
Inventor: WANG FEIJIU
IPC: A01N53/08
Filed: 2003-05-29
Abstract: 一种缓释药物防治海带虫害方法，是采用缓释剂与专门驱杀海带幼苗敌害生物(水虱和藻钩虾)的药物研制成的特效缓释药物，利用小细绳、或海带幼苗暂养坠石、也可用海带夹苗绳直接浸蘸缓释药物晒干备用。当海带幼苗下海暂养时，在虫害重灾区将缓释药绳绑缚到海带苗绳上；在虫害中轻度灾区采用药物坠石并和药绳间隔使用；或在养成前期用浸蘸缓释药物的夹苗绳直接夹苗使用。该方法操作简单，成本低，具有非常强的专一驱杀水虱和藻钩虾作用，而对海带等养殖种类无不良影响。可有效地预防虫害生物对海带幼苗的掠食，使海带幼苗保苗率达到90％以上。该缓释药物作用持久，一次使用可持续约30天。在海带幼苗暂养期间和海带养成前期均可应用。
Patent CN-1486610-A (CN)
Title: 鱼藤酮微胶囊剂及其制备方法
Inventor: XU HANHONG
IPC: A01N25/28
Filed: 2003-07-28
Abstract: 本发明涉及以鱼藤酮为主要杀虫成分配制的农药制剂及其制备方法。具体地是以鱼藤酮晶体粉末或含鱼藤酮的提取物为原料制造鱼藤酮微胶囊及其制备方法，通过界面聚合法，以鱼藤酮晶体粉末或含鱼藤酮的提取物为囊芯，制成鱼藤酮微胶囊剂。本制剂具有防虫效果好，持效期长，制备工艺简单，生产成本低等优点。
Patent CN-1492164-A (CN)
Inventor: YAO YAN-AN
IPC: H02K7/116
Filed: 2003-09-30
Abstract: 电机齿轮一体化动力传动装置，由动力部分和变速部分组成。变速部分包括太阳轮(10)、行星齿轮(5)、内齿圈(4)、行星架(6)和输出轴(13)。动力部分包括电源引线(1)、极靴(2)、接线器电极(8)、接线器引出轴(9)、线圈(11)和转子(12)；线圈(11)固定在内齿圈(4)内，转子(12)的前端通过螺钉与输出轴(13)连接，后端通过轴承支撑在接线器引出轴(9)上，接线器引出轴(9)前端通过螺栓固定于太阳轮(10)上，后端通过轴承支撑在外壳(7)上；线圈(11)的电源经过电源引线(1)、极靴(2)、接线器电极(8)和接线器引出轴(9)引入。该装置减少了组成元件，显著地提高传动效率，降低传动系统的整体重量。
Patent CN-1668605-A (CN)
Inventor: NEST SURLERAUX DOMINIQUE LOUIS
IPC: A61P43/00
Filed: 2003-05-16
Abstract: 本发明涉及具有式(I)化合物及其N－氧化物、盐、立体异构形式、外消旋混合物、前药、酯和代谢物。它还涉及它们作为广谱HIV蛋白酶抑制剂的用途，它们的制备方法以及包含它们的药用组合物和诊断试剂盒。本发明还涉及本发明化合物与另一种抗逆转录病毒剂的组合，以及它们在试验中作为参考化合物或作为试剂的用途。
Patent CN-1671735-A (CN)
Inventor: SEBASTIAN BAILON PASCAL
IPC: A61K47/48
Filed: 2003-07-16
Abstract: 提供了聚乙二醇化的T1249多肽化合物。还提供了包含聚乙二醇化的T1249多肽化合物的药物组合物以及生产此类化合物及组合物的方法。还提供了包含与可药用赋形剂混合的式(I)化合物的药物组合物的用途，用于制备抑制HIV感染的药物。
Patent CN-1685738-A (CN)
Inventor: HEKSTRA GERBEN J
IPC: G09G3/34
Filed: 2003-09-30
Abstract: 本发明涉及一种显示彩色图象的彩色显示器件和一种操作该显示器的方法。该彩色显示器件设置有多个像素，具有不同预定的辐射光谱的至少两个可选择的光源，与所述可选择的光源结合能在所述显示面板上分别产生第一和第二原色的颜色选择装置，和控制装置，其被设置成交替选择所述可选择的光源中的一个并给像素的一部分提供与用选择的光源获得的相应原色对应的图象信息。以时间连续和空间连续的方式选择该显示器件的原色，这能减小色分散。
Patent CN-1695241-A (CN)
Inventor: KOICHI TSUCHIYA MASATO MASHIMO
IPC: H01L21/683
Filed: 2003-05-13
Abstract: 本发明提供可以更为安全、简单并且可靠地将晶片分离并且能够提高进行晶片分离的处理速度的晶片分离方法、晶片分离装置及使用了该晶片分离装置的晶片分离机。在从该最上层的晶片的惯析线轴(A－A’、B－B’)绕顺时针或逆时针错开了角度15°～75°的轴向(L－L’)上，推压该最上层的晶片，并且按照使该最上层的晶片的弯曲应力产生于与该惯析线轴错开了的轴向(L－L’)上的方式，使该最上层的晶片的周缘部向上方翘起，同时向该最上层的晶片的下面和相邻的下侧的晶片的上面之间吹入流体，并且使该最上层的晶片上升，从而将晶片分离。
Patent CN-85109737-A (CN)
IPC: C11D17/00
Filed: 1985-12-19
Abstract: 本发明涉及固体香皂，含有0.01至10％重量的天然或合成增稠剂，以改进香皂的加工性能、质地、润湿性以及泡沫的数量和质量。
Patent CN-87106789-A (CN)
Title: 带有异形衬垫的塑料密封盖
IPC: B65D53/02
Filed: 1987-10-05
Abstract: 一种只需较小操作扭矩的塑料密封盖，它包括底座，侧壁和从底座圆周部位延伸到侧壁某一部位的衬垫，衬垫相对于底座表面是倾斜的，以便与底座形成一个大约25°到90°的角。倾斜的衬垫使得可以减小操作扭矩，同时提供满意的密封效果。衬垫可以是平面形，凹形，凸形或环形的，而且可以由一个或一个以上位于底座和侧壁上的定位机构来固定。
Patent CN-1030320-A (CN)
Title: 磁带加载装置
Inventor: YAMANAKA TAKASHI
IPC: G11B15/665
Filed: 1988-05-30
Abstract: 本磁带加载装置具有：磁带引导机构，用作引导
磁带从磁带盒内到该盒外，再从抹去磁头的前方通过
而滑动到与该抹去磁头及导柱接合的位置；使该磁带
引导机构滑动的马达；以及支撑上述抹去磁头的可动
构件。其特征为设有可动构件驱动装置，用来使上述
磁带引导机构不接触上述可动构件而从上述抹去磁
头的前方通过后，再利用上述马达驱动上述可动构
件，使上述的抹去磁头接触在上述磁带上。
Patent CN-1048827-A (CN)
Title: 容器
Inventor: COWLAND JOHN PATRICK
IPC: B65D30/18
Filed: 1990-06-30
Abstract: 本发明提供了一种添加到液体介质中的物品的
包装件，其中，该包装件包括一个在液体介质中易于
溶解和/或可弥散的第一部分，以及在液体介质中不
易于溶解和/或弥散的另一部分。
Patent CN-1069530-A (CN)
Title: 大面积一次性精确刷镀技术
Inventor: ZHONG YU
IPC: C25D5/06
Filed: 1991-08-10
Abstract: 大面积一次性精确刷镀技术使大面积工件一次
刷镀完成并保证工件之尺寸精确和光洁度提高。属
于金属表面处理技术领域。 
     本发明所使用之刷镀溶液具有很强“容纳性”和
稳定性，所使用之可溶性金属阳极，按工件的形状和
面积的大小制成象形型阳极并在刷镀施工中保证阴
极与阳极之间的电阻均匀性，相对运动速度等值性和
镀面上溶液分配均匀性。这样，不仅使大面积工件一
次刷镀完成，而且镀层厚度均匀，光洁度提高，不必精
磨加工即可装配使用。
Patent CN-1064629-A (CN)
Title: 爪式无尘粉碎机
Inventor: YIN KEJIAN XIE DEGUI CHEN W
IPC: B02C13/13
Filed: 1991-03-14
Abstract: 一种爪式无尘粉碎机，由机体1转子盘2和齿盘
3构成。机体1上有粉碎室4，其不封闭的一面装有
活门6，活门6上固定有气流导向装置，所述装置包
括气室11，一块有孔并且倾斜安装的导料板将气室
隔为两部分，气室11的上部有进料装置，下部有底面
为曲面的出料斗，转子盘2搅动的气流在粉碎机内部
循环，使出料口无尘，效率提高2.12倍，噪声分贝数
下降。
Patent CN-1062418-A (CN)
Title: 雷达系统
Inventor: BLEIJERVELD HENDRIK CORNELIS
IPC: G01S13/42
Filed: 1991-12-10
Abstract: 本发明涉及产生目标的二维或三维位置指示的
雷达系统。通过周期性地绕倾斜轴倾斜天线，以致使
无线波瓣平面与地平面的法线形成一个倾斜角，并且
通过将不同倾斜角下获得的方位角数据和范围数据
混合，最终得到三维位置指示。雷达系统装有双稳定
装置，该装置也保证天线装置能够倾斜。
Patent CN-1180716-A (CN)
Title: 在聚碳酸酯产物中作为bpa清除剂的原酸酯
Inventor: WU P P
IPC: C08G64/40
Filed: 1997-09-30
Abstract: 通过在原酸酯或原碳酸酯存在下加热所述树脂,除去聚碳酸酯树脂中未反应的、在其制备过程中所用二元酚反应物的残留物。
Patent CN-1192968-A (CN)
Title: 笔具
Inventor: HIDEHIRA KAGEYAMA
IPC: C08K3/04
Filed: 1998-03-09
Abstract: 一种可防止因前端构件的磨耗而有碍美观及防止造成不良书写习惯从而易导致单边磨损,或笔具于书写时滑动或转动因而对圆珠笔或原子笔而言会导致墨水滴出、挤出或钢珠脱落的笔具,该笔具将书写时抵接纸面滑动而可能磨耗的前端构件的前端管嘴(6,16)、前端芯管(4a)及与前端管件一体成型的滑件或笔锥体(4,14)等用含有可增加耐磨性的添加物的合成树脂组合物制成,而此添加物为钼、钨、矽、石墨及碳等中的任一种。
Patent CN-1202516-A (CN)
Title: 精炼薄荷原油和薄荷素油的制备方法
Inventor: LIU FENG
IPC: C11B9/02
Filed: 1998-02-24
Abstract: 本发明公开了一种精炼薄荷原油和薄荷素油的制备方法,它是采用间接蒸馏工艺技术,通过高温,负压作用,让薄荷油在装置中定向流动,使其按不同比重,不同沸点达到各种成分的分离,得到含量较高的精炼原油和精炼素油。从而改变了传统的落后加工方式,大大的提高了出口原油的创汇和使用价值。
Patent CN-1243914-A (CN)
Title: 内燃机中喷射用气体燃料供给的调节系统
Inventor: PADAUAN F
IPC: F02M21/02
Filed: 1999-06-30
Abstract: 内燃机设有GPL型气体燃料供给的调节系统;该调节系统安装在喷射燃料所用的装置上。该系统包括两个步进式“步—步”操作的小型发动机,以实现调节气体流量的操作。
Patent CR-20110590-A (CR)
Title: Formas estables de n-(2,6-dimetil-4-morfolin-4-il-fenil)3,3- dimetil-butiramida
Inventor: TREPPENDAHL SVEND
IPC: C07D295/135
Filed: 2011-11-11
Abstract: Se proporcinan formas polimórficas de N-(2,6-dimetil-4-morfolin-4-il-fenil)3,3- dimetil-butiramida, junto con un proceso para la elaboración de dicho compuesto.
Patent CR-20150668-A (CR)
Title: Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
Inventor: HELDWEIN KURT ALEX
IPC: C07K16/28
Filed: 2015-12-17
Abstract: La presente invención se refiere a anticuerpos monoclonales que se unen al receptor 1 de LDL (lipoproteína de baja densidad) oxidado similar a lectina humana (en lo sucesivo, denominado a veces como "LOX-1"), y composiciones farmacéuticas y métodos de tratamiento que comprenden los mismos.
Patent CR-20210380-A (CR)
Title: Apparatus and method for monitoring valve expansion
Inventor: SCHWARCZ ELAZAR LEVI
IPC: A61M25/01
Filed: 2020-01-14
Abstract: Embodiments of a prosthetic valve delivery apparatus are disclosed. The delivery apparatus includes a first portion configured to maintain a fixed spatial relationship relative to a first end of the prosthetic valve and a second portion configured to maintain a fixed spatial relationship relative to a second end of the prosthetic valve during radial expansion of the prosthetic valve. The first portion includes one or more reference radiopaque markers and the second portion includes an indicator radiopaque marker. A position of the indicator radiopaque marker relative to the one or more reference radiopaque markers measures an axial distance between the first and second ends of the prosthetic valve indicative of a corresponding diameter of the prosthetic valve as it is radially expanded from a radially compressed state to a radially expanded state.
Patent EC-SP014054-A (EC)
Title: Activadores de glucoquinasa alquinil fenil heteroaromatica
Inventor: MAHANEY PAIGE ERING
IPC: C07D403/12
Filed: 2001-05-03
Abstract: Las para - alquinil fenil amidas heteroaromáticas que son activas como activadores de la glucoquinasa para incrementar la secreción de insulina lo cual las hace útiles en el tratamiento de la diabetes tipo II.
Patent EC-SP055568-A (EC)
Title: Composición de comprimido de liberación sostenida de pramipexol
Inventor: AMIDON GREGORY E
IPC: A61K9/22
Filed: 2005-01-24
Abstract: La presente invención se refiere a formulaciones de comprimido, y más particularmente a una composición de comprimido de liberación sostenida para la administración oral de un fármaco o profármaco soluble en agua, ejemplificado por diclorhidrato de pramipexol.
Patent EC-SP055776-A (EC)
Title: Reducción de la dureza de una barra mediante la reposición de nutrientes en de una matriz
Inventor: AKASHE AHMAND
IPC: A23L1/30
Filed: 2005-05-04
Abstract: En este documento se describen los métodos y composiciones para la reposición de micronutrientes, especialmente del calcio en un producto alimenticio, tal como una barra nutricional, para minimizar la dureza y extender su vida útil. Los métodos y composiciones de la presente invención comprenden la aplicación de una capa de un micronutriente, especialmente del calcio, a una matriz de un núcleo de una barra alimenticia fortificada. La matriz es una capa de confitura o revestimiento de baja humedad, preferiblemente una capa o revestimiento de chocolate o caramelo que contiene calcio u otro micronutriente solubilizado en ella. El producto alimenticio resultante contiene ventajosamente una cantidad sustancial de micronutrientes sin que se afecte adversamente sus cualidades organolépticas tal como la textura.
Patent EC-SP088888-A (EC)
Title: Antagonistas del receptor de vanilloides del subtipo (vr1)
Inventor: BROWN BRIAN S
IPC: A61K31/519
Filed: 2008-11-14
Abstract: La presente invención se refiere a compuestos de fórmula (I) (I)donde las variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, y A4 son como se definen en la memoria descriptiva, y métodos de uso para tratar dolor, dolor neuropático, alodinia, dolor asociado con inflamación o una enfermedad inflamatoria, hiperalgesia inflamatoria, hiperactividad vesical e incontinencia urinaria.
Patent EC-SP982774-A (EC)
Title: Uso de pirazolo (3.4.6) piridina como inhibidores de cinasa dependientes de ciclina
Inventor: KIMBALL DAVID S
IPC: C07D239/26
Filed: 1998-12-09
Abstract: Los compuestos de fórmula (gráfico), y las sales farmacéuticamente aceptables de los mismos para uso como inhibidores de cinasas dependientes de ciclina, en donde: X es O,S (O)m: Y es alquilo, arilo, arialalquil, heteroarilo, heteroarilalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquilalquilo, -o-alquilo, o-arilo, NR4R6. R3 e hidrógeno o alquilo inferior; R4 es hidrógeno, alquilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquilalquilo, -o-alquilo -o-arilo; R5 es hidrógeno, alquilo, arilo arilalquilo, heteroarilo, alquilheteroarilo, cicloalquilo, alquilcicloalquilo, heterocicloalquilo, alquilheterocicloalquilo, -o-alquilo, -o-arilo y mes 0,1 o 2 Los compuestos de la fórmula I son inhibidores de la proteína cinasa y son útiles en el tratamiento y prevención de enfermedades proliferativas, por ejemplo, cáncer, inflamación y artritis. También podrian ser útiles en el tratamiento de enfermedades neurodegenerativas tales como enfermedad de Alsheimer, enfermedades cardiovasculares, enfermedades virales y enfermedades fúngicas.
Patent FI-20030285-A (FI)
Inventor: JAERVINEN AIMO ENSIO
IPC: C22B3/08
Filed: 2003-02-26
Abstract: The invention relates to method for leaching zinc-containing materials in connection with the electrolytic recovery of zinc. According to this method, the feed materials i.e. zinc calcine and zinc sulphide, are leached in three stages, in which he sulphuric acid content of the stages rises in accordance with the direction in which the solids are moving. The solids and solution formed in the leaching stages are routed throughout the process countercurrently in relation to each other.
Patent FR-1553385-A (FR)
IPC: B29C65/02
Filed: 1968-02-02
Granted: 1969-01-10
Abstract: 1,145,965. Moulding caps on to tubes; searing non-metallic sheet material. TELEPHON-UND TELEGRAPHEN - FABRIKS A.G. KAPSCH & SOHNE IN WIEN. 10 Jan., 1968 [8 Feb., 1967], No. 1473/68. Headings B5A and B5K. A cap B is welded to a tube M using a reciprocable mould 1 of a material having a high thermal conductivity, the upper region of the mould S being intermittently heated whilst the lower region 2 of the mould is continuously cooled by a cooling channel 3. The heat is applied to the upper region during each welding operation and is removed subsequent thereto so that the cooled region of the mould quickly advances into the upper region to cool and solidify the welded parts. In the embodiment shown in the Figure, a heated plate 7 is lowered into contact with the mould which is forced down over the parts into contact with a stop 8. After welding the plate is removed and after a short interval, the mould is re-raised. In alternative embodiments the upper region of the mould may be heated by electrical or ultrasonic oscillations.
Patent FR-1603107-A (FR)
Title: Polynitriles prodn - using metal cyanide and unsatd amine catalyst
IPC: C08G73/00
Filed: 1968-06-11
Granted: 1971-03-22
Abstract: Prodn. of poly(aliphatic or aromatic) nitriles by opening C triple bond N bond using, as catalyst, a gp. VIII metal cyanide and unsatd. 3 - 40C primary, secondary or tertiary amine.
Patent GB-1052363-A (GB)
IPC: B41M5/04
Abstract: 1,052,363. Printing processes. COLUMBIA RIBBON & CARBON MANUFACTURING CO. Inc. April 23, 1965, No. 17216/65. Heading B6C. A dry method of duplicating from an imaged master sheet having a soluble hectograph dyestuff image thereon which comprises superposing said master sheet with its image in surface contact with a coating on a copy sheet, and in the absence of conventional spirit duplicating fluids, is characterized in that the copy sheet coating has a porous sponge-like structure and comprises a vinyl resin having dispersed within the pores thereof droplets of a pressure-exudable oily liquid which is a solvent for the dyestuff of the image and a non-solvent for and incompatible with the vinyl resin. When the master and copy sheets are in contact, sufficient pressure, e.g. 500 p.s.i., is applied to the copy sheet to exude the liquid solvent from its coating such that the solvent dissolves off a portion of the image dyestuff to form a copy of the image on the surface coating of the copy sheet. The copy sheet coating may comprise 2 to 6 parts by weight of substantially colourless droplets of a pressure-exudable oily liquid including oleic acid and butyl stearate per 1 part by weight of a vinyl chloride-vinyl acetate copolymer resin.
Patent GB-1052464-A (GB)
IPC: F16D48/02
Abstract: 1,052,464. Clutch control. ENGLISH ELECTRIC CO. Ltd. Sept. 21, 1965 [Sept. 25, 1964], No. 39142/64. Heading F2L. In order to check whether it is necessary to adjust a clutch 10 having an overcentre or toggle mechanism which is supplied with pressure fluid for engagement and disengagement, an auxiliary line 28 leading to a clutch control servo 17 and having a restriction 32 is provided for giving a slow build-up of pressure in the servo, the pressure when the overcentre mechanism goes overcentre being indicated by an indicator 33. If this pressure does not fall within a predetermined range the clutch is adjusted until it does. As shown pneumatic pressure from a line 20 is normally supplied under the control of a valve 21 to lines 27, 22 for engaging and disengaging the clutch. Actuation of a valve 24 substitutes the line 28 for line 27 to give slow build-up for checking the clutch adjustment. As an alternative the line 28 may be associated with the release line 22. The clutch may be employed in a diesel locomotive.
Patent GB-1052850-A (GB)
IPC: A61J9/04
Abstract: 1,052,850. Feeding bottles. R. R. BUTTS. Nov. 26, 1963, No. 46648/63. Heading A5X. A feeding bottle comprises a main body and nipple portion 1, closed by a base portion 7 and is intended to be supplied filled ready for use. An air inlet valve 11, located within the body, is fitted to cooperate with a recess 10 in the base and, when the bottle is required for use, a pin is used to make perforations 20, 21 in the nipple and base respectively, the latter being so placed as to ensure correct functioning of the valve 11. The valve may be constructed as a spring-loaded ball, of the type shown, or as a hemispherical member mounted on a resilient blade welded to the interior of the base, but, in each case, all the parts are preferably made of a synthetic resin material such as polyethylene. The bottle may also contain a buoyant ball 22 which floats on the liquid contents of the bottle. When the contents are exhausted this ball drops down and lodges in the neck portion, as at 22, and prevents air being sucked through the nipple.
Patent GB-1052874-A (GB)
IPC: C08C19/10
Abstract: 1,052,874. Precipitating metals from solutions. BADISCHE ANILIN & SODA FABRIK A. G. Oct. 2, 1963 [Oct. 3, 1962], No.38740/63. Heading C7D. [ Also in Division C3] Finely divided metals, used as catalysts for isomerizing butadiene polymers (see Division C3), are produced by the reduction of compounds of transition metals of groups VI B, VII B and VIII of the Mendeleeff periodic system. In the examples the acetylacetonates of manganese and chromium are reduced with triethyl aluminium, that of ferric iron with diethyl aluminium hydride, diethyl zinc or phenyl lithium, and that of nickel with triethyl aluminium in the presence of triphenyl phosphine, all the reductions being effected under xylene. Further metal compounds and reducing agents are specified.
Patent GB-1054002-A (GB)
IPC: C23C4/10
Abstract: 1,054,002. A carbide flame spray material. METCO Inc. April 7, 1965 [Aug. 21, 1964], No. 14753/65. Heading C1A. [Also in Division C7] A flame spray material consists of carbides of tantalum, hafnium and zirconium; the tantalum is present in an amount 20-90 atomic per cent, preferably 75-85%, of the total metal content, the hafnium being 0.5 to 95%, preferably 0.5 to 25% of the HF + Zr metal content, the remaining metal content being zirconium. 45-55% of the composition may be carbon. The material may be in powder form of particle size-100 mesh to + 5 Á, preferably - 230 mesh to 10 Á, there being aggregates each containing (i) sub-grains of the carbides of Ta, Zr, HF; or (ii) sub-grains of tantalum carbide and a solid solution of zirconium and hafnium carbides; or (iii) a solid solution carbide of tantalum, hafnium and zirconium. The material may be softened by heating in a plasma flame and sprayed against the surface to be coated. It may be prepared (i) by mixing the metal oxides in the correct proportions with sufficient carbon for the reduction and carburization of the oxides, compacting, and sintering in a reducing atmosphere; (ii) by heating the mixed metal powders with carbon; or (iii) by mixing preformed carbide powders and heating e.g. in vacuo, at e.g. 2900-4000‹ F. to diffuse the carbides; or (iv) by heating the hydrides with carbon.