baber/WOPTO huggingface dataset:
Patent EP-0985488-B1 (EP)
Inventor: GRUBER KARL-HEINZ
IPC: B23Q3/06
Filed: 1999-08-20
Granted: 2004-09-08
Abstract: The work holder for a machine tool has a polygonal cross section with two parallel clamping faces (2) each with at least two rotary plates (11) in a row each connected to a drive. Each plate can be rotated in dependence on the direction of rotation of the holder.
Patent EP-1008829-B1 (EP)
Inventor: DUBOCAGE BERNARD
IPC: F42B5/03
Filed: 1999-10-15
Granted: 2004-01-07
Abstract: Nonlethal firearm projectile is made of a soft elastic composite material (I) comprising a particulate metal filler dispersed in a crosslinked polybutadiene matrix, where (I) has a Shore hardness of 2-30 and a density of 1.0-2.9, the filler has a density of 4-22 and the crosslinked polybutadiene has chains with a number-average molecular weight (Mn) of 500-10,000. Independent claims are also included for: (1) A process for producing the projectile, comprising: (a) mixing a liquid polybutadiene having reactive terminal groups and an Mn of 500-10,000 with a crosslinking agent and the filler; (b) introducing the resulting heat-curable paste into a mold; (c) crosslinking the polybutadiene by heating; and (d) removing the projectile from the mold; (2) a composite material as defined for (I); (3) a cylindrical firearm cartridge containing at least one projectile as above.
Patent EP-0981005-B1 (EP)
Inventor: HUGUET ALAIN
IPC: F16L37/133
Filed: 1999-07-13
Granted: 2002-09-25
Abstract: The gas cartridge coupling has a central core (8), a ring (9), a cylindrical casing (16) and a rotational control plate (23). The pressure parts of the ring legs (19) consist of radial tenons (18) on the cylinder which are inserted in the gaps (20) in the unlocked position. The legs have an inner bearing surface (22) supported on one of the tenons and moved radially to the outside of its external notch (21). The ring is connected to the rotational control plate which has an angular travel limited between locked and unlocked positions.
Patent EP-1088844-B1 (EP)
Inventor: SHIGEHARA KIYOTAKA
IPC: C08G69/02
Filed: 1999-04-19
Granted: 2004-12-15
Abstract: L'invention concerne un polyamide comprenant des motifs récurrents représentés par la formule (1) dans laquelle R1 représente un résidu hydrocarbure divalent dont la structure comprend éventuellement un hétéroatome exempt d'hydrogène actif. Ce polyamide présente un indice de réfraction élevé, est biodégradable et convient pour la production de fibres ou de plastique.
Patent EP-1082068-B1 (EP)
Title: Implantable intraluminal device
Inventor: CHERIF-CHEIKH ROLAND
IPC: A61F2/06
Filed: 1999-06-04
Granted: 2008-06-04
Abstract: A device implantable in the vascular ducts. The device includes an elongated intraluminal element that occupies a section of the vascular lumen so as to increase the speed at the vascular wall at the level of the element without decreasing the blood flow and without exerting any substantial mechanical action on the vascular wall, the element also includes a fixing device in the vascular lumen.
Patent EP-1082444-B1 (EP)
Inventor: ENGELHARDT JOHN F
IPC: C07H21/04
Filed: 1999-05-20
Granted: 2007-08-08
Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
Patent EP-1082244-B1 (EP)
Inventor: DIERINGER WERNER
IPC: B60T8/44
Filed: 1999-06-07
Granted: 2003-11-05
Abstract: L'objectif de l'invention est de créer un dispositif générateur de pression de freinage, qui soit plus compact, qui puisse être produit de façon meilleur marché et qui puisse être actionné de façon confortable, destiné à une installation de freinage hydraulique de véhicule. Ce dispositif peut être actionné par induction d'une force d'actionnement (FB) par l'intermédiaire d'un élément d'actionnement (2), pour produire une pression de freinage, destinée à au moins un frein de roue (3), par réduction du volume d'une chambre hydraulique (4), et est pourvu d'un servofrein (13) servant à superposer une force d'assistance primaire (FS1) à la force d'actionnement (FB) induite. Cet objectif est atteint par le fait que le dispositif comporte une chambre hydraulique (6) supplémentaire, dont le volume se réduit également lorsqu'une force d'actionnement (FB) est induite, qu'une pompe (10, 10') est disposée entre la sortie de la chambre hydraulique (6) complémentaire et le ou les freins de roue (3), laquelle refoule le fluide hydraulique depuis la chambre hydraulique (6) complémentaire vers le ou les freins de roue (3), et en ce que la sortie (10a) de la pompe (10, 10') est reliée à la sortie de la chambre hydraulique (4) pour superposer à la force d'actionnement (FB) induite et/ou à la force d'assistance primaire (FS1) une force d'assistance secondaire (FS2), ce qui a pour effet d'augmenter la pression de freinage destinée au(x) frein(s) de roue (3).
Patent EP-1095147-B1 (EP)
Inventor: KELLENBERGER JOHANNES LAURENZ
IPC: C12N1/21
Filed: 1999-07-06
Granted: 2006-03-22
Abstract: Nucleic acid molecules encoding at least part of a Type I polyketide synthase, and having a polylinker with multiple restriction enzyme sites in place of one or more PKS genes encoding enzymes associated with reduction, optionally further including nucleic acid incorporated into the polylinker, the further nucleic acid encoding one or more reductive enzymes; plasmids incorporating such nucleic acids; host cells transfected with such plasmids; methods relating thereto.
Patent EP-1121486-B1 (EP)
Inventor: AHVENNIEMI VESA
IPC: D21F7/00
Filed: 1999-08-19
Granted: 2004-07-14
Abstract: Method and apparatus for guiding a web of paper or board or, alternatively, an edge strip sheared therefrom, in a paper machine or finishing equipment, the method being particularly suited for threading the web tail or edge strip through the machine in conjunction with a production shutdown or after a web break. According to the invention, the web (6) or its tail sheared from the web so as to form an edge strip is supported electrically by means of taking surfaces or electrodes (3, 5) disposed on opposite sides of the web (6) to different potentials. Particularly advantageously, the web (6) or the edge strip can be adhered to a roll (16), a belt (7) or a wire by taking said support element to a lower potential and disposing a higher-potential electrode (5) or a number of electrodes to the opposite side of the web.
Patent EP-1040499-B1 (EP)
Inventor: HILLEBRAND DIETMAR
IPC: H01H71/10
Filed: 1999-08-11
Granted: 2006-03-15
Abstract: Disclosed is a coupling device that is located on the actuating member of a switching device (1) such as one as used in a power circuit breaker. The coupling device has a through hole (33) on the actuating member. A coupling element (40) can be inserted into said through hole. When the coupling element (40) is assembled, a first end section (47) thereof protrudes from one end (35) of the through hole (33). A second end section (47) thereof is flush with the opposite end (34) of the through hole (33). In this position, the coupling element (40) forms a recess (25) on one end of the actuating member and the end section (47) of the coupling element (40) protrudes on the other end. Said protruding end section (47) is embodied in such a way that it fits into the recess (25).
Patent EP-1141550-B1 (EP)
Inventor: NATHAN ROBERT
IPC: F04B1/14
Filed: 1999-10-15
Granted: 2004-10-13
Abstract: In order for a high-pressure cleaner having a reciprocating pump, on which there is positioned a pump head into which at least one piston, which can be moved back and forth in the longitudinal direction of the reciprocating pump, projects, the pump head comprising a suction connection, for feeding a cleaning liquid, and a pressure connection, for discharging the cleaning liquid, accommodating a plurality of regulating valves, being produced from plastics and being braced with the reciprocating pump by means of a clamping element, to be developed such that it can be produced more cost-effectively and assembled more straightforwardly, it is proposed that the clamping element has at least one U-shaped clamping bracket with a base part butting against the pump head and with two legs which are aligned substantially in the longitudinal direction of the reciprocating pump and the free ends of which butt against an abutment surface, produced from metal, of a piston guide of the reciprocating pump and can be connected releasably to the reciprocating pump.
Patent EP-1141696-B1 (EP)
Title: Method and apparatus for cure monitoring
Inventor: CHADWICK DUNCAN
IPC: G01N29/34
Filed: 1999-12-06
Granted: 2005-06-22
Abstract: A method and apparatus for monitoring the progress of the solidification of a solidifying material involves using a transmitter to transmit a relatively low frequency compression wave to the solidifying material. A receiver is provided for detecting the resonant compression wave vibrations induced in the solidifying material, and the detected wave vibrations are analyzed to obtain an indication of the progress of solidification.
Patent EP-1137598-B1 (EP)
Inventor: GAO YUAN
IPC: C01G53/00
Filed: 1999-11-12
Granted: 2003-04-23
Abstract: The present invention includes substantially single-phase lithium metal oxide compounds having hexagonal layered crystal structures that are substantially free of localized cubic spinel-like structural phases. The lithium metal oxides of the invention have the formula Li<SUB>alpha</SUB>M<SUB>beta</SUB>A<SUB>gamma</SUB>O<SUB>2</SUB>, wherein M is one or more transition metals, A is one or more dopants having an average oxidation state N such that +2.5<=N<=+3.5, 0.90<=alpha<=1.10, and beta+gamma=1. The present invention also includes dilithiated forms of these compounds, lithium and lithium-ion secondary batteries using these compounds as positive electrode materials, and methods of preparing these compounds.
Patent EP-1218220-B1 (EP)
Inventor: RAYNER GARY A
IPC: G07C5/08
Filed: 1999-12-10
Granted: 2004-09-15
Abstract: L'invention concerne un dispositif (10) autonome destiné à capturer des images vidéo suite à un événement déclencheur. Ce dispositif, composé d'un miroir (16) et d'un boîtier (18) contenant l'électronique et les éléments associés, peut être monté au pare-brise (14) d'un véhicule à la place d'un rétroviseur classique. Les éléments comprennent un ou plusieurs capteurs de données (40, 42), dont au moins un est un capteur d'images, ainsi qu'un circuit capteur de données et un circuit de capture. Le circuit capteur de données réagit à l'événement déclencheur et peut comprendre des capteurs de données couplés aux systèmes du véhicule, notamment au compteur de vitesse, au tachymètre, aux freins, aux signaux de tour ou analogues ou d'autres capteurs de données tels qu'un accéléromètre (40) ou un capteur de position du véhicule. L'événement déclencheur peut être, par exemple, une variation soudaine de l'accélération indiquant une collision imminente ou une variation du signal causée par tout capteur de données correspondant, y compris le capteur d'images. Le circuit de capture est connecté au capteur d'images et capture un signal représentant les images vidéo en les enregistrant dans une mémoire numérique, en les transmettant à un emplacement distant ou par d'autres moyens adéquats. Le circuit de capture met un terme à la capture du signal après la détection d'un événement de déclenchement assurée par le circuit capteur de données. Les données capturées décrivent les circonstances qui entraînent l'événement déclencheur. Les données peuvent être analysées pour être par la suite utilisées par la police, les assurances ou d'autres personnes menant une enquête afin de contribuer à jeter la lumière sur lesdites circonstances.
Patent EP-1128842-B1 (EP)
Inventor: FISHER CHARLES JACK
IPC: A61P37/06
Filed: 1999-11-10
Granted: 2006-03-15
Abstract: The present invention provides a method of treatment of heparin-induced thrombocytopenia (HIT) with protein C. The claimed invention provides a needed therapy for a potentially serious and debilitating disorder while avoiding complications such as bleeding tendency, toxicity and general side effects of currently available anticoagulant agents.
Patent IT-1309985-B1 (IT)
Inventor: CASTALDINI SILVANO
IPC: B65H29/00
Filed: 1999-04-28
Granted: 2002-02-05
Abstract: A method and unit for stacking groups of articles, the method being characterized by including the steps of:   successively forming a number of groups (13) at an input station (6);   feeding a group (13) from the input station to a stacking station (27); turning the group (13) over in a first direction about an axis (A) of substantially symmetry;   stacking the group (13) at the stacking station (27); and so on, turning one group (13) after another over in the opposite direction to the preceding group (13) and the following group (13), so as to form a stack (37) of articles (2) of substantially the same thickness on all sides. <IMAGE>
Patent IT-1266668-B1 (IT)
Title: Alfa, omega - alcandifenoli
Inventor: PITTELOUD RITA
IPC: C08L101/00
Filed: 1993-11-04
Granted: 1997-01-09
Abstract: Composizione contenente un prodotto organico sensibile nei confronti di una degradazione termica, ossidativa o/e attinica e almeno un composto di formula I (FORMULA I) in cui Z1 e Z2 indipendentemente l'uno dall'altro indicano C1-C18-alchile C5-C8-cicloalchile, fenil-C1-C4-alchile oppure (C1-C4-alchil) fenile e p indica un numero compreso tra 4 e 18, con la condizione che Z1 e Z2 indichino non contemporaneamente radicali alchilici terziari. Alcuni dei composti di formula I sono nuovi. I composti di formula I possono venire impiegati come stabilizzanti anche in miscela con composti di formula VI e/o di formula VII (FORMULE VI e VII) in cui n e i radicali R1, R1' ed A sono definiti nelle rivendicazioni 14 e 15.
Patent IT-1264972-B1 (IT)
Title: Processo per la produzione di policarbonati termoplastici
Inventor: KAUTH HERMANN
IPC: C08G64/20
Filed: 1993-11-16
Granted: 1996-10-17
Abstract: L'oggetto della presente invenzione è un processo per la produzione di policarbonati mediante transesterificazione in fusione con l'impiego di scarti di policarbonato.
Patent IT-1289910-B1 (IT)
Inventor: FANTUCCI MARIO
IPC: C07D277/30
Filed: 1997-01-17
Granted: 1998-10-19
Abstract: A process for the preparation of heteroaryl-zinc halides of the formula (II): Het-Zn-X, wherein Het is an optionally substituted 5 or 6 membered aromatic heterocyclic group with one or two heteroatoms selected among nitrogen, oxygen or sulphur; X is a chlorine, bromine or iodine atom; comprising metallation reaction of heteroarylhalide with metallic zinc optionally activated by washing with acids, is described. Compounds of the formula (II) are intermediates useful in the synthesis for the preparation of compounds endowed with pharmacological activity.
Patent IT-1298438-B1 (IT)
Inventor: BIRAGHI GIOVANNI
IPC: B29C45/72
Filed: 1998-02-23
Granted: 2000-01-10
Abstract: An injection molding machine for the production of preforms (1) of thermoplastic material, comprising a gripping hand (2) to take the preforms from the molds and bring them to a cooling plate (4) which by means of the nozzles (5) sucks up said preforms, which are cooled by heat exchange between their inner surface and the outer surface of the nozzles (5), the nozzles (5) being cooled by means of a cooling fluid circulating on the inside thereof and means being provided for rotating the plate (4) and for expelling the preforms which are collected by a conveyor belt and carried to a storage unit. <IMAGE>
Patent IT-1265573-B1 (IT)
Title: Forno di cottura di alimenti con porta perfezionata
Inventor: CAPPELLO MASSIMO
IPC: F24C15/14
Filed: 1993-09-17
Granted: 1996-11-22
Abstract: Forno per la cottura di alimenti, comprendente una porta d'accesso (1) incernierata verticalmente e dotata di un vetro esterno (2), una controporta (3) disposta sulla facciata interna di detta porta, ove detta controporta è dotata di una cerniera (4) lungo il bordo di incernieramento della porta d'accesso (1) al forno, ed è ruotabile rispetto a detta cerniera in una posizione distaccata da detta porta. Il forno comprende inoltre una grondaia (6) di raccolta della condensa lungo il bordo inferiore di detta porta, ove detta grondaia è dotata di un otturatore per liquidi (7) e un elemento di raccolta di liquidi (11), è disposto sporgente dal lato inferiore (10) della zona circostante la bocca del forno, in posizione sottostante detto otturatore per liquidi , che è normalmente chiuso quando la porta è aperta, e si apre automaticamente alla chiusura della porta.
Patent JP-2866374-B1 (JP)
Title: エピタキシャル成長用ガスの供給方法及びその装置
IPC: H01L21/205
Filed: 1998-05-13
Granted: 1999-03-08
Abstract: 【要約】
【課題】  エピタキシャル成長用ガスを所定の濃度及び 所定の圧力に容易に設定でき、１基のガス供給装置によ り複数の反応炉に一定の濃度を有する高純度のエピタキ シャル成長用ガスを連続的に安定して供給する。
【解決手段】  液体原料を気化器１９でこの液体の沸点 以上の温度で加熱して気化し、気化した原料ガスとキャ リアガスとを混合器４３で所定の濃度で混合し、この混 合ガスをその凝縮点を越えた温度で加熱保温しながら混 合ガスの流量を調整した後、この混合ガスをその凝縮点 を越えた温度で加熱保温しながらエピタキシャル成長用 反応炉５１に供給する。気化器において加熱媒体の温度 を一定にして液体原料を気化し、気化器内のガスの圧力 により気化器への液体原料の供給量を調整すれば、気化 器の液面レベルを常に一定に制御することができる。
Patent JP-2831345-B1 (JP)
Title: 引出箱
IPC: A47B88/00
Filed: 1997-06-25
Granted: 1998-12-02
Abstract: 【要約】
【課題】  引出しを引出した際に、引出しの横方向への がたつきの発生を防止する。
【解決手段】  引出し収納部４の対向する両側板５に前 後方向Ｂに引出しレールがそれぞれ設けられ、各引出し レールに沿って引出し２がスライド自在に支持された引 出箱１である。引出し収納部４の入口付近の側板５部分 に一対のがたつき防止用のクリップ７が対向して配設さ れる。引出し２の後端部側の両側面２ａには上記一対の クリップ７と相対する位置に一対の凸部８が突設され る。各クリップ７には引出し２の引出し方向Ｂ 1  に向か う程引出し２の側面２ａに向けて突出した傾斜面９が設 けられる。引出し２を引出したときに各凸部８が各クリ ップ７の傾斜面９にそれぞれ当接することにより引出し ２の横方向Ｃへの動きが阻止されるように構成されてい る。
Patent JP-3049396-B1 (JP)
Title: カメラのブレ防止具
IPC: G03B17/02
Filed: 1999-08-06
Granted: 2000-06-05
Abstract: 【要約】
【課題】  ブレのない写真を撮るため、鼻をカメラの裏 蓋に圧接しても裏蓋が鼻の皮脂で汚れない。
【解決手段】  表面に、撮影者の鼻を入れて底面を鼻で 圧接するための凹部３が設けられている基台２、凹部を 含む基台の表面に設けられた皮脂吸収層４、カメラの裏 蓋に着脱自在に取付けるため、基台２の裏面に設けられ た粘着層とからなる。カメラの裏蓋にブレ防止具１を鼻 を介して圧接して、カメラを構えられるので、ブレのな い写真撮影が可能になる。しかも、ブレ防止具には皮脂 吸収層が設けられているため、裏蓋が汚れるおそれがな い。
Patent JP-3093758-B1 (JP)
Title: 包装棒状飯及びその包装シート
IPC: A23L7/10
Filed: 1999-10-20
Granted: 2000-10-03
Abstract: 【要約】
【課題】  棒状飯の両端面も包むことができ、且つ簡単 に包装を解くことのできる包装シートを提供する。
【解決する手段】  外フィルム１と内フィルム４との間 にシート状海苔３を挟み、内フィルム４は外フィルム１ の長手方向の両側縁がら内向きに延びて外フィルム１の 幅方向の略中央部で重なりあった２枚のフィルム片41、 41からなる棒状飯用包装シートにおいて、内フィルム４ の各フィルム片41、41は、相手フィルム片との重なり側 端縁から外側に折り返されて外フィルムの側縁側に延び た中間片41a及び該中間片の外端縁から内側に延びたカ バー片41bを有している。
Patent JP-2997259-B1 (JP)
Title: 還元鉄または鉄カーバイド製造用散気管式多室分割型流動層炉
IPC: C22B1/16
Filed: 1998-12-07
Granted: 2000-01-11
Abstract: 【要約】
【課題】  還元鉄または鉄カーバイド製造用散気管式多 室分割型流動層炉を提供すること。
【解決手段】  第一流動層炉１と第二流動層炉２を縦方 向に配した仕切板５によって多室に分割する。反応ガス を加熱する第一加熱炉３から第一流動層炉下方に至るガ スパイプ１１を設置し、このガスパイプ１１から集合管 １２を経て各分割室ごとにグリッド状にパイプを分岐さ せ、このグリッド状パイプに多数のガス吹出しノズルを 設ける。同様に、反応ガスを加熱する第二加熱炉４から 第二流動層炉下方に至るガスパイプ１１ａを設置し、こ のガスパイプ１１ａから集合管１２ａを経て各分割室ご とにグリッド状にパイプを分岐させ、このグリッド状パ イプに多数のガス吹出しノズルを設ける。そして、第一 流動層炉１または第二流動層炉２において、すべての分 割室の流動層高（Ｈ 1 ）または（Ｈ 2 ）がそれぞれほぼ同 一になるように、原料投入側の分割室から製品排出側の 分割室にかけて各分割室ごとのガス吹出しノズルの高さ を各分割室間の原料移送力によって生じる層高差に応じ て段階的に低くしている。
Patent JP-2995473-B1 (JP)
Title: 盆受板上の生線香群の整列補助装置
IPC: A61K8/00
Filed: 1998-11-25
Granted: 1999-12-27
Abstract: 【要約】
【目的】  乾燥時に盆受板上の生線香群が反らずに、整 列して真っ直ぐに乾燥できるようにすることを目的とす る。
【構成】  盆受板１上に縦出し成型する前受装置２６か ら送られてきた盆受板１上の生線香群２の両側に、生線 香群２の断面厚みに相当する厚みの矩形板からなる整列 添板８を供給する整列添板供給装置３を備えたことを特 徴とする盆受板上の生線香群の整列補助装置。
Patent MD-4430-B1 (MD)
Title: Compositions and methods for treating hepatitis C virus
Inventor: CLEARY DARRYL G
IPC: A61P31/14
Filed: 2012-11-27
Abstract: The invention relates to medicine, in particular to pharmacology and infectious diseases, namely to compositions and unit dosage forms for the treatment of hepatitis C virus infection.The pharmaceutical composition comprises:a) about 25% to about 35% w/w of crystalline form having the structure:(GS-7977); andb) at least one pharmaceutically acceptable excipient,wherein the crystalline GS-7977 has HRPD 2θ-reflections (°) at about: 6.1 and 12.7.According to the invention, also disclosed are methods of treating subjects infected with hepatitis C virus comprising administering to the subjects for a time period effective amounts of GS-7977 and of interferon-free ribavirin.
Patent NO-315803-B1 (NO)
Inventor: WALTON JOHN MAWSON
IPC: D07B1/16
Filed: 2000-06-16
Abstract: A filler element is located between each adjacent pair of outer strands of a wire rope and interlocks with the adjacent strands. The filler elements provide the rope with substantially smooth outer surface reducing vibration of the rope passing over a pulley. Filler elements are disclosed consisting of an elastometic or polymeric material having an oriented molecular structure aligned along the filler element and also aligned in a generally radial direction with respect to the rope.
Patent NO-328390-B1 (NO)
Inventor: HORSTMANN MICHAEL
IPC: A61K47/22
Filed: 2000-07-05
Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
Patent NO-322828-B1 (NO)
Inventor: RIDDER LUCRECE DE
IPC: C08K5/5419
Filed: 2001-11-20
Abstract: The present invention relates to use of an inhibitor compound in an organosilicon composition for inhibiting curing of the organosilicon composition by a hydrosilylation reaction at a temperature of 40° C. to 100° C., or 100° C. and above, and a pressure of 1x10<6 >N/m<2 >to 5x10<6 >N/m<2>, or 5x10<6 >N/m<2 >and above. In a preferred application the organosilicon composition cures to form a silicone gel or elastomeric seal or plug within an oil or gas well. Preferred inhibitor compound is 1-ethynyl-1-cyclopentanol or 1-ethynyl-1-cyclohexanol.
Patent NO-327097-B1 (NO)
Inventor: FREYNE EDDY JEAN EDGARD
IPC: C07D403/14
Filed: 2004-05-07
Abstract: This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R<SUP>1 </SUP>is hydrogen; aryl; formyl; C<SUB>1-6</SUB>alkylcarbonyl; optionally substituted C<SUB>1-6</SUB>alkyl; C<SUB>1-6</SUB>alkyloxycarbonyl; optionally substituted C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R<SUP>2 </SUP>is hydrogen, C<SUB>1-10</SUB>alkyl, C<SUB>2-10</SUB>alkenyl, C<SUB>2-10</SUB>alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R<SUP>3 </SUP>is hydrogen; hydroxy; halo; optionally substituted C<SUB>1-6</SUB>alkyl or C<SUB>2-6</SUB>alkenyl or C<SUB>2-6</SUB>alkynyl; C<SUB>1-6</SUB>alkyloxy; C<SUB>1-6</SUB>alkylthio; C<SUB>1-6</SUB>alkyloxycarbonyl; C<SUB>1-6</SUB>alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C<SUB>1-6</SUB>alkyl)amino; polyhaloC<SUB>1-6</SUB>alkyl; polyhaloC<SUB>1-6</SUB>alkyloxy; polyhaloC<SUB>1-6</SUB>alkylthio; R<SUP>21</SUP>; R<SUP>21</SUP>-C<SUB>1-6</SUB>alkyl; R<SUP>21</SUP>-O-; R<SUP>21</SUP>-S-; R<SUP>21</SUP>-C(-O)-; R<SUP>21</SUP>-S(-O)<SUB>p</SUB>-; R<SUP>7</SUP>-S(-O)<SUB>p</SUB>-; R<SUP>7</SUP>-S(-O)<SUB>p</SUB>-NH-; R<SUP>21</SUP>-S(-O)<SUB>p</SUB>-NH-; R<SUP>7</SUP>-C(-O)-; -NHC(-O)H; -C(-O)NHNH<SUB>2</SUB>; R<SUP>7</SUP>-C(-O)-NH-; R<SUP>21</SUP>-C(-O)-NH-; -C(-NH)R<SUP>7</SUP>; -C(-NH)R<SUP>21</SUP>; R<SUP>4a </SUP>or R<SUP>4b </SUP>each independently represent hydrogen, R<SUP>8</SUP>, -Y<SUB>1</SUB>-NR<SUP>9</SUP>-Y<SUB>2</SUB>-NR<SUP>10</SUP>R<SUP>11</SUP>, -Y<SUB>1</SUB>-NR<SUP>9</SUP>-Y<SUB>1</SUB>-R<SUP>8</SUP>, -Y<SUB>1</SUB>-NR<SUP>9</SUP>R<SUP>10</SUP>; provided that -X-R<SUP>2 </SUP>and/or R<SUP>3 </SUP>is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.