baber/WOPTO huggingface dataset:
Patent MX-2022013045-A (MX)
Title: Synthesis of cantharidin.
Inventor: SCHOW STEVEN R
IPC: C07D495/22
Filed: 2020-07-13
Abstract: The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds {i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions {e.g., infectious diseases and skin conditions).
Patent MX-2022015384-A (MX)
Title: Process for acetic acid production by removing permanganate reducing compounds.
Inventor: LEE DAVID
IPC: C07C17/386
Filed: 2021-06-03
Abstract: This process relates to controlling acetal formation when removing acetaldehyde from a methanol carbonylation process using an extractive distillation column. Acetals may be formed by a secondary reaction of acetaldehyde and an alcohol (such as methanol). The process controls the formations to prevent excess acetal accumulation in the lower stream from the extractive distillation column.
Patent MX-PA00006739-A (MX)
Title: Start-up procedure for direct smelting process.
Inventor: PETER DAMIAN BURKE
IPC: C21B13/00
Filed: 2000-07-07
Abstract: A procedure for starting up a direct smelting process for producing iron from a metalliferous feed material in a metallurgical vessel is disclosed. The vessel is of the type which includes a plurality of feed material injection lances/tuyeres (11, 13). The start-up procedure includes the steps of:(a) preheating the vessel; (b) supplying a charge of molten iron to the vessel and forming a molten bath in the vessel,(c) supplying carbonaceous material and flux to the molten bath and injecting oxygen-containing gas through one or more than one feed material injection lance/tuyere and combusting carbon and bath derived gas (if present) and thereby heating the molten bath and generating slag; and(d) suppling metalliferous feed material to the vessel while continuing supply of carbonaceous material and flux and injection of oxygen-containing gas and smelting metalliferous feed material and producing molten iron and thereby completing the start-up procedure.
Patent MX-PA00007758-A (MX)
Title: Gypsum-cement system for construction materials.
Inventor: DAVID BONEN
IPC: E04C2/04
Filed: 2000-08-09
Abstract: A composition for use in construction materials, which may be substituted for high performance concrete, patching materials, joint compounds, and the like, such as backer boards or panels, which includes a settable calcium sulfate, preferably a hemihydrate, Portland cement, a finely divided pozzolanic material, lime, and an aggregate, optionally including other additives. The volume ratio of the aggregate to the combined calcium sulfate, Portland cement, pozzolanic material, and lime (a cementitious binder) is equal to or greater than 2/1. Panels made from this composition are useful, particularly when exposed to water since they have good dimensional stability.
Patent MX-PA00008854-A (MX)
Title: Mirror mounting assembly with modular components.
Inventor: ALEXANDER STENZEL
IPC: B60R1/06
Filed: 2000-09-07
Abstract: A modular mounting assembly is provided for mounting a mirror housing to a vehicle and suitable for use with a family of mounting bars including of at least two mounting bars, each mounting bar within the family of mounting bars having a unique diameter, the modular mounting assembly including, for example, a base member configured for attachment to the mirror housing and defining a channel portion for receiving a given one of the at least two mounting bars from within the family of mounting bars, the channel portion sized for receiving a given one of at least two mounting bars from within the family of mounting bars, the channel portion sized for receiving at least two of the mounting bars. A given cap member selected from a family of cap members is provided configured for selective attachment to the base member, the family of cap members including at least two cap members, each cap member defining a securing portion uniquely configured to mate with a respective one of at least two m ounting bars and to secure the respective base member to the at least two mounting bars.
Patent MX-PA00011708-A (MX)
Title: Recombinant venezuelan equine encephalitis virus vaccine.
Inventor: BENNETT ALICE MARIE
IPC: C12N15/63
Filed: 1999-05-05
Abstract: A prophylactic or therapeutic vaccine for use in protecting mammals such as humans or animals against Venezelan Equine Encephalitis virus (VEE) is described. In particular, the vaccine comprises a recombinant virus such as a recombinant vaccinia virus which is able to express the structural genes of VEE in attenuated form, which has been modified to increase the protective effect of the vaccine. This is achieved by modifying the sequence of the attenuated VEE strain and/or putting this under the control of modified promoter which increases expression from the vector. Formulations of the vaccine as well as methods of treatment using the vaccine are also described.
Patent MX-PA00012719-A (MX)
Title: Material handling gate.
Inventor: KRAEUTLER BERNARD
IPC: E06B3/48
Filed: 1999-06-17
Abstract: The invention concerns a material handling gate post comprising a guide rail (1) formed by single-piece extrusion, or two parts interlocking on each other. The gate post comprises a planar surface (14F), designed to be placed against a wall, for suitably positioning the door and the rail, so as to allow room, on both sides of the door, for receiving the shutter in case it slips out of the guide rail.
Patent MX-PA01000194-A (MX)
Title: Display device.
Inventor: PERRA ANTONIO GUISEPPE
IPC: G09F19/18
Filed: 1999-06-24
Abstract: The invention relates to a display device for displaying visual information, comprising: at least one image-forming element; at least one light source for generating a light beam, which in co-action with the image-forming element produces an illuminated image; optical means for processing the light beam and/or illuminated image, and a projection surface for receiving the illuminated image, wherein the image-forming element is flat and the projection surface forms at least a part of a cylinder wall.
Patent MX-PA01004116-A (MX)
Title: Device for signaling the position of an elevator car in the case of passenger evacuation.
Inventor: ERIC ROSSIGNOL
IPC: B66B3/02
Filed: 2001-04-25
Abstract: A device for signaling the position of an elevator car in the case of passenger evacuation includes a measurement circuit connected to a landing door safety chain of the elevator installation. The measurement circuit has at least one LED that indicates to a rescuer person the presence of the elevator car at a floor.
Patent MX-PA01005431-A (MX)
Title: Method of producing a polymer network.
Inventor: GOTTSCHALL KLAUS
IPC: C08F8/34
Filed: 1999-11-26
Abstract: The invention relates to a method of producing a polymer network, according to which (i) one or more polymers are provided which are cross-linked with one another intramolecularly or intermolecularly or intra- and intermolecularly by covalent or non-covalent bonding, (ii) the conformation of at least one of the polymers is adapted to at least one template compound, resulting in at least one preferred conformation of the at least one polymer, (iii) at least one of the preferred conformations obtained according to (ii) is fixated by cross-linking.
Patent MX-PA01005951-A (MX)
Title: Gel for treating muscular pain.
Inventor: ESPERANZA OCHOA RAMOS GARCIA
IPC: A61P29/00
Filed: 2001-06-13
Abstract: The present invention refers to a gel for treating muscular pain composed of natural products, which relieve pain caused by fibromyalgia, rheumatism, arthritis, muscle strains, colds, muscle tears, etc, without containing any anti-inflammatory agent that may cause allergies to people who are sensitive to those type of substances.
Patent MX-PA01011248-A (MX)
Title: Lactic acid bacteria with anxiolytic properties and uses thereof.
Inventor: ANTOINE JEAN-MICHEL
IPC: A61K35/74
Filed: 2000-05-05
Abstract: The invention concerns lactic acid bacteria with anxiolytic properties and not inducing sedative effect. Said lactic acid bacteria are useful in particular for preparing foods or medicines.
Patent MX-PA01013423-A (MX)
Title: Cell culture systems and methods for organ assist devices.
Inventor: COSMAN MAURY D
IPC: A61M1/36
Filed: 2000-06-21
Abstract: The invention features modular cell culturing devices (1) including one or more flat - plate modules (2), and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices (1) can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver assist systems, for production of cells, for production of cell-derived products, such as proteins or viruses, or for systems to treat biological liquid to remove toxins, such as ammonia, or add cell-synthesized products, or both.
Patent MX-PA02001146-A (MX)
Title: Mammalian cytokines; related reagents.
Inventor: TIMANS JACQUELINE C
IPC: C07K14/52
Filed: 2000-07-27
Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
Patent MX-PA02001200-A (MX)
Title: Self-cooling can.
Inventor: RAMSEY CHRISTOPHER PAUL
IPC: B65D81/18
Filed: 2000-08-02
Abstract: A self-cooling can (10) comprising an evaporator unit (30) within the can (10) and an absorber unit (20) provided outside the container body (10). A beverage within the can (10) is cooled by means of vapour which passes from the evaporator (30) to the absorber (20) when these are connected so as to provide a vapour path between the two. The path for water vapour, for example, to pass from the evaporator (30) to the absorber (20) is formed by rupturing a panel (40) between evaporator (30) and the absorber (20) when the can (10) and part or all of the absorber (20) are rotated relative to each other.
Patent MX-PA02005672-A (MX)
Title: Antimicrobial glove and method of making same.
Inventor: MEROVITZ GERALD
IPC: A41D19/00
Filed: 2002-06-07
Abstract: The present invention provides a multiple, long-term use, antimicrobial glove. The glove is formed from one or more layers of material having a latex-based matrix with an antimicrobial agent, such as diiodomethyl-p-tolylsulfone, homogeneously incorporated therein. Optionally, the glove may also have additional antimicrobial agents incorporated therein. The glove of the present invention is capable of inhibiting molds and other microbes from proliferating on any surface of the glove, during both storage and use, which results in the prevention of malodor, discoloration, and degradation of the glove. Also, the glove of the present invention is believed to be capable of providing an antimicrobial effect to surfaces contacted by the antimicrobial glove.
Patent MX-PA02006031-A (MX)
Title: Dosage forms having a barrier layer to laser ablation.
Inventor: GEERKE JOHAN H
IPC: A61J1/03
Filed: 2000-12-11
Abstract: A dosage form for delivery of a therapeutic agent to a subject is described. The dosage form contains: (a) an outer wall defining an interior compartment; (b) within the interior compartment, a therapeutic agent; (c) at least one exit orifice formed by laser ablation of the outer wall for release of the agent therethrough, and (d) a barrier layer disposed between the outer wall and the interior compartment in at least a region corresponding to the exit orifice. The barrier layer comprises a material that allows the barrier layer to remain intact during laserformation of the at least one exit orifice in the outer wall. Also disclosed is a method for controlling the depth of laser ablation of a dosage form during laser formation of an exit orifice in an outer wall of the dosage form.
Patent MX-PA02010589-A (MX)
Title: Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein.
Inventor: LACEY DAVID LEE
IPC: A61K47/48
Filed: 2001-04-27
Abstract: The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP. In accordance with the present invention, modulators of PTH and PTHrP comprise: (a) a PTH/PTHrP modulating domain; and (b) a vehicle, such as a polymer (e.g. PEG or dextran) or an Fc domain, which is preferred; wherein the vehicle is covalently attached to the C-terminus of the PTH/PTHrP modulating domain. The vehicle and the PTH/PTHrP modulating domain may be linked through the N- or C-terminus of the PTH/PTHrP modulating domain, as described further below. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain. Preferred PTH/PTHrP modulating domains comprise the PTH and PTHrP-derived amino acid sequences described hereinafter. Other PTH/PTHrP modulating domains can be generated by phage display, RNA-peptide screening and the other techniques mentioned herein. Such peptides typically will be modulators of both PTH activity and PTHrP activity, although such techniques can be used to generate peptide sequences that serve as selective modulators (e.g., agonists of PTH activity but not PTHrP activity).
Patent MX-PA02012587-A (MX)
Title: Method, device and warehouse for cultivating crop plants and grafts thereof.
Inventor: VAN WEEL PETER
IPC: A01G1/06
Filed: 2001-06-18
Abstract: Method for cultivating crop plants having a shoot-root plant body, wherein during growing part of the stem preferably adjacent the roots is prepared such that new roots grow on said stem part, which new roots are brought into contact with a grow medium, such that during production of crop the stem length between the shoot furthest from the roots and the roots in contact with the grow medium closest to said shoot is maintained at a relatively short length, compared to a normal length of said plant at the same age.
Patent MX-PA02012848-A (MX)
Title: Piperidine coumpounds for use as ccr-3 inhibitors.
Inventor: BHALAY GURDIP
IPC: A61P29/00
Filed: 2001-07-10
Abstract: Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more halogen atoms, Ar2 is phenyl or naphthyl which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-alkoxycarbonyl, R1 is hydrogen or C1-C8-alkyl optionally substituted by hydroxy, C1-C8-alkoxy, acyloxy, N(R2)R3, halogen, carboxy, C1-C8-alkoxycarbonyl, -CON(R4)R5 or by a monovalent cyclic organic group, R2 and R3 are each independently hydrogen or C1-C8-alkyl, or R2 is hydrogen and R3 is acyl or -SO2R6, or R2 and R3 together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R4 and R5 are each independently hydrogen or C1-C8-alkyl, or R4 and R5 together with the nitrogen atom to which they are attached denote a 5- 6-membered heterocyclic group, R6 is C1-C8-alkyl, C1-C8-haloalkyl, or phenyl optionally substituted by C1-C8-alkyl, and n is 1, 2, 3, or 4, with the proviso that when Ar1 is p-chlorophenyl and R1 is hydrogen, Ar2 is not phenyl or p-nitrophenyl. The compounds are useful as pharmaceuticals.
Patent MX-PA03000730-A (MX)
Title: Geothermal turbine.
Inventor: TAKAGI KENTARO
IPC: C22C32/00
Filed: 2003-01-24
Abstract: <P>PROBLEM TO BE SOLVED: To provide a geothermal turbine improving corrosion resistance of turbine components such as a rotor blade, a stationary blade and a turbine rotor shaft to be operated under a strict steam environment and lengthening service life by performing a secular deterioration prevention measure. <P>SOLUTION: In this geothermal turbine 10, a turbine stage 12 is constituted of the stationary blade 14 of a nozzle diaphragm and the rotor blade 15 arranged on a downstream side of the stationary blade 14. A shroud 37 is provided on each blade top part of the rotor blade 14. An eaves part 38 of a nozzle diaphragm outer ring 17 is oppositely provided at the radial direction outside of the shroud 37. A seal fin 41 projecting toward an inner peripheral surface of the eaves part 38 is provided at the radial direction outside of the shroud 37 to constitute a steam leakage prevention structure of the rotor blade top part. The eaves part 38 of the nozzle diaphragm outer ring 17 is provided with a smooth inside surface 38a. <P>COPYRIGHT: (C)2003,JPO.
Patent MX-PA03003231-A (MX)
Title: Journal bearing and thrust pad assembly.
Inventor: TITUS DAVID G
IPC: F16H57/022
Filed: 2003-04-11
Abstract: An apparatus for rotatably mounting and axially fixing a gear on a shaft comprises a bushing fixed within a bore of the gear. A sleeve is received on and fixed relative to the shaft. The sleeve is surrounded by and journalled for rotation within the bushing. A thrust ring is fixed relative to and projects radially from the shaft on one side of the gear. A retainer on the one side of the gear defines a circular channel within which the annular thrust ring is axially confined.
Patent MX-PA03003961-A (MX)
Title: Hydrophilic polymer blends used for dry cow therapy.
Inventor: VINCI ALFREDO
IPC: A01N25/24
Filed: 2001-10-18
Abstract: The present invention provides a mammalian teat dip composition capable of being used during a mammal s dry period comprising a solution of a film-forming polymer blend comprising a first polymer component which is an organic, solvent-soluble, preformed, thermoplastic polyurethane having no reactive isocyanate groups and a second polymer component which is a hydrophilic poly(N-vinyl lactam), said blend capable of withstanding exposure to water without significant loss of said hydrophilic poly(N-vinyl lactam) in an amount sufficient to form a water-resistant film upon topical application to mammalian skin; and wherein said blend comprises from about 10 to about 80 weight percent of said first polymer in combination with said solvent and from about 1 to about 20 weight percent of said second polymer; and at least one antimicrobial agent in an amount sufficient to treat and protect mammalian skin from infection; wherein said composition is capable of being removed by peeling.
Patent MX-PA03004832-A (MX)
Title: Compounds and their uses.
Inventor: LI JIA-HE
IPC: A61K31/55
Filed: 2001-11-30
Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
Patent MX-PA03005049-A (MX)
Title: Method for producing a brake disk and a core forming tool.
Inventor: DEBUS BJORN
IPC: F16D65/12
Filed: 2001-12-05
Abstract: The invention relates to a method for producing a brake disk (B) that comprises a supporting part ( 2 ) and a friction ring (R). The inventive method involves the following working steps: manufacturing, especially by casting, the supporting part ( 2 ) with at least one radially protruding projection ( 10 ) situated on the periphery of the supporting part; forming a cast core ( 14 ), which is made of core sand and which surrounds the projection ( 10 ) over a foot section ( 10 a) that is assigned to the supporting part ( 2 ), onto the supporting part ( 2 ) while sealing a free end section ( 10 b) of the projection ( 10 ) so that this end section ( 10 b) is not made wet by the sand of the cast core ( 14 ); casting the friction ring (R) onto the supporting part ( 2 ), which is provided with the cast core ( 14 ), while casting around the free end section ( 10 b) of the projection ( 10 ). The inventive method enables the production of brake disks, which are additionally optimized with regard to their function, with a supporting part and friction ring that are cast at different times. The invention also relates to a core forming tool, which is particularly suited for carrying out the inventive method.
Patent MX-PA03007747-A (MX)
Title: Plasma surface graft process for reducing thrombogenicity.
Inventor: LAROCHE GAETAN
IPC: A61F2/06
Filed: 2002-02-28
Abstract: In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.
Patent MX-PA03008033-A (MX)
Title: Medicinal composition containing 1,3-thiazine derivative.
Inventor: HIROYUKI KAI
IPC: C07D417/12
Filed: 2002-02-14
Abstract: A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: <CHEM> wherein R<1> is optionally substituted heterocyclic group or the like; R<2> and R<2> each is independently hydrogen or the like; m is an integer of 0 to 2; A is optionally substituted aromatic carbocyclic group or the like.
Patent MX-PA03008237-A (MX)
Title: Improved imr having synergistic effect with stabilizing system additives and catalyst package.
Inventor: MICHAEL T WELLMAN
IPC: C08G18/22
Filed: 2002-03-08
Abstract: This invention relates to a process for the production of a polyurethane elastomer by reacting a reaction mixture via the reaction injection molding process in a one-shot process at an isocyanate index of from 90 to 120. This reaction mixture comprises: (A) an isocyanate-reactive component having a molecular weight of 400 to 12,000, a functionality of about 2 to about 8 and being capped with 13 to 21 % by weight of ethylene oxide, wherein the isocyanate-reactive groups are selected from the group consisting of hydroxyl groups, amine groups and mixtures thereof; (B) an isocyanate-reactive component comprising (1) an isocyanate-reactive component containing at least two hydroxyl groups and having a molecular weight of from 62 to 399, and (2) an isocyanate-reactive component selected from the group consisting of (a) an isocyanate-reactive group containing tertiary amine polyether corresponding to a specific formula, (b) at least one organic amine compound containing at least two amine groups which are reactive with isocyanate groups; (c) potassium halide; (d) an internal mold release agent; (e) at least one catalyst, and (f) a polyisocyanate component, and optionally, one or more surfactants.