baber/WOPTO huggingface dataset:
Patent WO-2020180592-A1 (WO)
Inventor: WHIDDON RICHARD MURRAY
IPC: E21B43/10
Filed: 2020-02-27
Abstract: One illustrative method for top to bottom expansion of tubulars (14, 17) within a wellbore comprises positioning the tubular (14, 17), with an expansion mandrel (18) positioned therein, within the well and expanding the tubular (14, 17) by forcing the expansion mandrel (18) through the tubular (14, 17) in a down-hole direction (27) of the well while forcing well fluid displaced by the expansion of the tubular (14, 17) into the formation.
Patent WO-2020219776-A1 (WO)
Inventor: LEE KUNWOO
IPC: C08G69/48
Filed: 2020-04-23
Abstract: Provided is a polymer comprising a hydrolysable polymer backbone, the polymer backbone comprising (i) monomer units with a side chain comprising a hydrophobic group; (ii) monomer units with a side chain comprising an oligoamine or polyamine; and optionally (iii) monomer units with a side chain comprising an ionizable group, as well as a method of preparing said polymer, and a method of delivering a nucleic acid and/or polypeptide to a cell using the polymer.
Patent WO-2020232124-A1 (WO)
Inventor: AY HAKAN
IPC: G01R33/56
Filed: 2020-05-13
Abstract: L'invention concerne un système d'analyse d'image comprenant au moins un processeur et au moins une mémoire. Le système d'analyse d'image est conçu pour recevoir des données d'image associées au cerveau d'un patient, les données d'image comprenant une première image d'imagerie pondérée en diffusion (DWI) tridimensionnelle (3D) acquise à l'aide d'un système d'imagerie par résonance magnétique (IRM) et une seconde image DWI 3D, fournir simultanément la première image DWI 3D à un premier canal d'un modèle entraîné et la seconde image DWI 3D à un second canal du modèle entraîné, recevoir un indicateur associé à la première image DWI 3D et à la seconde Image DWI 3D en provenance du modèle, générer un rapport en fonction de l'indicateur et provoquer l'émission en sortie du rapport vers une mémoire et/ou un dispositif d'affichage.
Patent WO-2020247171-A1 (WO)
Title: Drive schemes for transparent tunable optical elements
Inventor: SMYTH KATHERINE MARIE
IPC: G02F1/01
Filed: 2020-05-19
Abstract: A transparent optical element includes a primary electrode, a secondary electrode overlapping at least a portion of the primary electrode, an electroactive layer disposed between and abutting the primary electrode and the secondary electrode, and a control system operably coupled to at least one of the primary electrode and the secondary electrode and adapted to provide a drive signal to actuate the electroactive layer within an aperture of the transparent optical element.
Patent WO-2020242950-A1 (WO)
Title: Anti-csf1r antibodies, il10 fusion proteins, and uses thereof
Inventor: CHEN HUNG-KAI
IPC: C12P21/08
Filed: 2020-05-22
Abstract: The present disclosure provides antibodies, including antibody fusions, which specifically bind to human CSF1 receptor protein (huCSF1R) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by huCSF1R, such as regulation of TAMs in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+ T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CSF1 binding to CSF1R.
Patent WO-2021162734-A1 (WO)
Title: Storage device with increased endurance
Inventor: ALROD IDAN
IPC: G07C5/08
Filed: 2020-06-05
Abstract: A black box device for a vehicle includes a data storage system for recording event data fed to the black box from various vehicle sensors. The data storage system includes a memory having memory cells and a controller in communication with the memory. The controller is configured to receive data and determine one or more memory cells as a destination for the data to be written. The controller is configured to determine a wear level of the memory cells and select a subset of program states of the memory cells based on the wear level; and program the memory cells using respective subsets of program states for each respective memory cell.
Patent WO-2021006973-A1 (WO)
Title: Using secure memory enclaves from the context of process containers
Inventor: RENKE MAXWELL CHRISTOPHER
IPC: G06F21/57
Filed: 2020-06-08
Abstract: Memory is partitioned and isolated in container-based memory enclaves. The container-based memory enclaves have attestable security guarantees. During provisioning of the container-based memory enclaves from a container image, a purported link in the container to a memory address of the enclave is modified to verifiably link to an actual memory address of the host, such as partitioned memory enclave. In some instances, enclave attestation reports can be validated without transmitting corresponding attestation requests to remote attestation services, based on previous attestation of one or more previous container attestation reports from a similar container and without requiring end-to-end attestation between the container and remote attestation service for each new attestation request.
Patent WO-2020257681-A1 (WO)
Inventor: KIRSHNER JESSICA R
IPC: C07K16/46
Filed: 2020-06-19
Abstract: Provided herein are methods of treating cancer using bispecific antigen-binding molecules that bind to prostate-specific membrane antigen (PSMA) and CD3. According to certain embodiments, the antibodies useful herein bind human PSMA with high affinity and bind CD3 to induce human T cell proliferation. According to certain embodiments, bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, and a second antigen-binding molecule that specifically binds human PSMA are particularly useful herein. In certain embodiments, the bispecific antigen-binding molecules in combination with an anti-4-1BB agonist are capable of inhibiting the growth of prostate tumors expressing PSMA. The bispecific antigen-binding molecules in combination with an anti-4-1BB agonist are useful for the treatment of diseases and disorders in which an upregulated or induced targeted immune response is desired and/or therapeutically beneficial, for example, in the treatment of various cancers.
Patent WO-2021061256-A1 (WO)
Inventor: KIM SEUNG WOOK
IPC: G02B30/26
Filed: 2020-07-07
Abstract: In one implementation, a method of operating a lenticular display is performed by a device including a processor, non-transitory memory, an image sensor, and a lenticular display. The method includes displaying, via the lenticular display, first content at a horizontal angle of a first user and second content, different than the first content, at a horizontal angle of a second user. The method further includes displaying, via the lenticular display, the first content at a second horizontal angle of the first user and the second content at a second horizontal angle of the second user.
Patent WO-2021021468-A1 (WO)
Inventor: LOVITT ANDREW
IPC: H04R3/00
Filed: 2020-07-17
Abstract: A system reduces power consumption by optimizing a selection of acoustic sensors of a sensor array based on environmental parameters of a local area. The system includes the sensor array including the acoustic sensors configured to detect sound in a local area, and processing circuitry. The processing circuitry is configured to: determine an environmental parameter of the local area; determine a performance metric for the sensor array; determine a selection of a subset of acoustic sensors from the acoustic sensors of the sensor array that satisfies the performance metric based on the environmental parameter of the local area; and process audio data from the subset of the acoustic sensors of the sensor array.
Patent WO-2021016130-A1 (WO)
Title: Wastewater treatment through controlled prioritization of microorganism digestion function
Inventor: OHKI AKIYOSHI
IPC: B01F25/60
Filed: 2020-07-17
Abstract: Increased control and efficiency over the wastewater (11) purification can be achieved through creating conditions that allow the operator to selectively prioritize the digestive function of microorganism in activated sludge. The gas-dispersion return sludge (36) is created using a reactive gas (37), which is blended with sludge (21) to create a mixture of gas and liquid, which is passed through an atomizer (24) or a cavitation pump (22) to instantly render the reactive gas (37) to an ultra-fine bubble state. At least a portion of the ultra-fine bubbles dissolve within the gas-dispersion return sludge (36), activating the dormant microorganisms. Due to a complete or an almost complete absence of biodegradable material in the gas-dispersion return sludge (36), the microorganism prioritize their digestive function, and when exposed to biodegradable pollutants present in wastewater (11), digest the pollutants using biochemical pathways different from the ones used in nature.
Patent WO-2021026380-A1 (WO)
Title: Composés de phényltriazole pour le traitement de la douleur
Inventor: WOODS JAMES R
IPC: C07D221/24
Filed: 2020-08-06
Abstract: L'invention concerne des composés qui sont utiles dans le traitement de la douleur chez un sujet. L'invention concerne également une composition pharmaceutique comprenant des composés ou des sels pharmaceutiquement acceptables de ceux-ci, et un support pharmaceutiquement acceptable et des procédés de traitement de la douleur chez un sujet en ayant besoin.
Patent WO-2021041663-A1 (WO)
Title: Procédés et systèmes d'évaluation du risque de troubles d'utilisation d'une substance
Inventor: DONALDSON KERI
IPC: C12Q1/6858
Filed: 2020-08-27
Abstract: Des systèmes et des procédés permettant de prédire le risque d'un trouble d'utilisation de substance et permettant de fournir un support de décision à des professionnels de soins de santé afin de mettre en œuvre une recommandation de régime de traitement et d'atténuer tout risque potentiel d'un trouble d'utilisation de substance sont fournis ici. Certains modes de réalisation comprennent des procédés permettant de prédire le risque d'un trouble d'utilisation de substance au moyen de modèles d'apprentissage automatique et des systèmes associés permettant de fournir un support de décision à des professionnels de soins de santé afin de mettre en œuvre un régime de traitement et d'atténuer le risque de trouble d'utilisation de substance.
Patent WO-2021046540-A1 (WO)
Title: Graph-manipulation based domain-specific execution environment
Inventor: HUNTER EDWARD
IPC: G06F16/2455
Filed: 2020-09-08
Abstract: A method includes obtaining program state of a self-executing protocol, wherein the program state includes a set of conditional statements and a directed graph including a set of vertices and a set of directed edges, each respective vertex associated with a respective category label of a set of mutually exclusive categories. The method may include receiving an event message including a set of parameters, selecting a first subset of vertices triggered by the event message and a second subset of vertices based on the first subset of vertices. The method may include determining an aggregated parameter based on a subset of conditional statements, where each respective conditional statement is associated with a respective vertex that is associated with a first category label of the set of mutually exclusive categories. The method may include storing the aggregated parameter in persistent storage.
Patent WO-2021158258-A1 (WO)
Title: Lube distribution apparatus for use with sperm collection device
Inventor: HAMBLIN WILLIAM
IPC: A61H9/00
Filed: 2020-09-09
Abstract: A lube distribution apparatus for use in connection with a sperm collection device is provided and configured to be installed on the sperm collection device in lieu of the end cap. The lube distribution apparatus comprising a main body having a cylindrical opening at a first end thereof, the cylindrical opening having means for engaging an open end of the sperm collection device. A lubricant reservoir is located within the main body of the lube distribution device for housing lubricant to be used in the sperm collection device. Injection means are provided for injecting lubricant from the lubricant reservoir into the sperm collection device. The lube distribution apparatus may further include an end cap removably affixed to a second end of the main body and enclosing the lubricant reservoir. A vent for allowing outside air to enter the lubricant reservoir during actuation of the injection means may also be provided. The vent may be located in the end cap or, alternatively, directly in the main body of the lube distribution device.
Patent WO-2021071959-A1 (WO)
Title: Molecular signatures of radiation sensitivity in tumors, and methods of use thereof
Inventor: HIGGINSON DANIEL SMITH
IPC: G16B25/10
Filed: 2020-10-07
Abstract: The present invention relates to molecular signatures in genomic DNA that are associated with sensitivity of tumors, such as HPV-associated tumors, to treatment with radiation therapy. The present invention provides methods of analyzing tissue samples, or DNA obtained therefrom, to assess the presence of such molecular signatures, methods of predicting whether a tumor in a subject will be sensitive to treatment with radiation therapy based on the presence of such signatures, and methods of treating subjects with radiation therapy if such signatures are present.
Patent WO-2021081099-A1 (WO)
Title: Linear slide mechanism
Inventor: PETERSON TED
IPC: B29C45/33
Filed: 2020-10-21
Abstract: An injection molded slide actuator assembly which has a frame, a slide carrier and a slide track member. The injection molded slide actuator has an X, Y, and Z axis with the slide track member having at least one track slot extending along the y and the Z direction and said slide carrier having at least one cooperating outwardly extending side members for engaging the at least one track slot.
Patent WO-2022086528-A1 (WO)
Inventor: CARBUNE VICTOR
IPC: G01C21/36
Filed: 2020-10-22
Abstract: To provide content-aware audio navigation instructions, a client device executing a mapping application obtains one or more audio navigation directions for traversing from a starting location to a destination location along a route. The client device also identifies electronic media content playing from a source different from the mapping application which is executing at the client device or in proximity to the client device. The client device determines characteristics of the electronic media content and adjusts the audio navigation directions in accordance with the characteristics of the electronic media content. Then the client device presents the adjusted audio navigation directions to a user.
Patent WO-2021087040-A1 (WO)
Inventor: ENQVIST PER ANDREAS JON
IPC: G01T1/18
Filed: 2020-10-29
Abstract: A system and method for detecting radiological sources with improved accuracy. The system comprises at least a first radiological sensor, at least a first three-dimensional (3-D) sensor and processing logic. The first radiological sensor detects radiation emitted by a radiological source and outputs a radiation count rate. The 3-D sensor detects distance of a moving carrier of the radiological source from the radiological sensor and outputs a 3-D sense signal containing first distance domain information. The processing logic is configured to perform a data-fusion algorithm that converts the radiation count rate into second distance domain information and combines the second distance domain information with the first distance domain information to obtain fused data. The datafusion algorithm compares the fused data with a threshold value to determine whether the detected radiation is a true positive or corresponds to background radiation.
Patent WO-2021092080-A1 (WO)
Inventor: STICE STEVEN L
IPC: A61K39/00
Filed: 2020-11-04
Abstract: Disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, to the central nervous system of a subject, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) conjugated to the surface of an extracellular vesicle (EV) derived from a neural cell, e.g., a neural progenitor cell or a neural stem cell. Conjugates comprising neural EVs coupled to a polypeptide, such as an antibody or antigen binding portion thereof, and methods of use thereof, are also provided. Also disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) loaded within the lumen of an extracellular vesicle (EV) derived from neural cells.
Patent WO-2021097216-A1 (WO)
Title: Active noise cancellation systems with convergence detection
Inventor: JAIN ANKITA D
IPC: G10K11/178
Filed: 2020-11-13
Abstract: An input signal representative of an undesired acoustic noise in a region is captured by one or more first sensors and processed to generate a cancellation signal. An output signal is generated based on the cancelation signal to cause one or more acoustic transducers to cancel, at least in part, the undesired acoustic noise in the region. A feedback signal representative of residual acoustic noise in the region is captured by one or more second sensors. A characteristic of each of the feedback signal, the cancellation signal, and a combination of the cancellation signal and the feedback signal is determined. One or more thresholds are compared to a ratio of (i) the characteristic of the combination of the cancellation signal and the feedback signal and (ii) a combination of the characteristic of the feedback signal and the characteristic of the cancellation signal to determine a convergence state.
Patent WO-2021108428-A1 (WO)
Inventor: YOUNG-DIXON BRENDAN
IPC: A61N1/372
Filed: 2020-11-24
Abstract: Techniques are described, for medical devices that deliver electrical stimulation using current or voltage regulators having an adjustable master amplitude. One example method includes receiving, via a programmer for an electrical stimulator, user input indicating a desired electrical current amplitude, and selecting a first fraction adjustment or a second fraction adjustment, as a target adjustment for achieving the desired electrical current amplitude. A neuromodulation system comprises: a first electrode; a second electrode; a stimulation generator configured to deliver first stimulation pulses to the first electrode and second stimulation pulses to the second electrode, wherein a first electrical current amplitude of the first stimulation pulses is a first fraction of a master amplitude and a second electrical current amplitude of the second stimulation pulses is a second fraction of the master amplitude; and a processor configured to generate an initial instruction for the stimulation generator to deliver (i) the first simulation pulses based on the first fraction of the master amplitude, and (ii) the second stimulation pulses based on the second fraction of the master amplitude, receive user input comprising a desired electrical current amplitude, determine that an adjustment to the first electrical current amplitude of the first stimulation pulses is required based on the desired electrical current amplitude, and determine, based at least in part on a comparison of the desired electrical current amplitude to the master amplitude, a target adjustment, wherein the processor is further configured to (A) determine, as the target adjustment, an adjustment to at least the first fraction, or (B) determine, as the target adjustment (i) an adjustment to the master amplitude, and (ii) an adjustment to at least the second fraction relative to the master amplitude adjustment, and generate, based at least in part on the target adjustment, an adjustment instruction for the stimulation generator to deliver the first stimulation pulses at the desired electrical current amplitude and deliver the second stimulation pulses at approximately the same second electrical current amplitude.
Patent WO-2021138039-A1 (WO)
Title: No sugar added multilayer edible products comprising a center and a barrier layer
Inventor: NOWAK ALLISON THERESE
IPC: A23L25/00
Filed: 2020-12-15
Abstract: A multilayer edible product includes a center; a barrier layer directly encompassing at least a portion of the center. The barrier layer includes a hydrophilic powder and a source of fat. The multilayer edible produce further includes an outer layer directly encompassing the barrier layer and indirectly encompassing the center. The center has at least one of a fat content that is either greater than or less than a fat content of the outer layer, or a water activity that is either greater than or less than a water activity of the outer layer. A composition of the barrier layer is different than a composition of the center and a composition of the outer layer, and the multilayer edible product does not include any added sugar.
Patent WO-2021127072-A1 (WO)
Inventor: HSIEH HSUEH
IPC: A63H3/24
Filed: 2020-12-17
Abstract: A water apparatus comprising a shell surrounding a reservoir that rotates about a pivot point between at least a first position and a second position. When the shell is in the first position, the reservoir and the top portion of the shell are at a first balance point, which comprises the shell being in an open position and the reservoir being able to retain water. When the shell is in the second position, the reservoir and the top portion of the shell are at a second balance point, which comprises the shell being in a closed position and the rigid tube being able to release water.
Patent WO-2022139854-A1 (WO)
Inventor: FRIPP MICHAEL LINLEY
IPC: E21B33/126
Filed: 2020-12-30
Abstract: A 3D printed barrel slip that includes a radially expandable barrel slip body that is movable from an unexpanded position to an expanded position; wherein the body has an outer surface that, when in the unexpanded position, defines a first radius; wherein the first radius is associated with a first curvature; and wherein, when in the expanded position, portion(s) of the outer surface has a second curvature that is less than the first radius. The body is an integrally formed single-component body that defines an external surface; and an internal chamber isolated from the external surface. The internal chambers affect the strength of portions of the body to control the timing of deployment of the barrel slip.
Patent WO-2020257824-A1 (WO)
Inventor: ZAMPINI DANIEL
IPC: B61L23/04
Filed: 2020-06-19
Abstract: The present disclosure includes a portable rail safety system configured to determine a position of a rail switch. The rail safety system may include a rail switch detector, one or more rail switch beacons, a work block marker, a personal alert device, a collision avoidance system or combination thereof. In some aspects rail switch detector includes a first detector configured to be positioned between switch rails of a rail track and having a body, a first sensor coupled to the body and configured to detect a first switch rail tip of the switch rails, and a controller configured to calculate a first distance between the first sensor and the first switch rail tip and based on the first distance, determine a position of the switch rails between a first position and a second position.