Patent SG-11201909243T-A (SG)
Title: New bicyclic pyrazole derivatives
Inventor: GRIEBENOW NILS
IPC: A61K31/429
Filed: 2018-04-23
Abstract: 1 O 71. (I) It-- R2 N—N O 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT mu °million °nolo Oil mo Ho O II111110uOIIIIII IE (10) International Publication Number WO 2018/197401 Al (51) International Patent Classification: CO7D 513/00 (2006.01) A61K 31/429 (2006.01) A61P 31/00 (2006.01) (21) International Application Number: PCT/EP2018/060313 (22) International Filing Date: 23 April 2018 (23.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17168558.9 27 April 2017 (27.04.2017) EP (71) Applicant: BAYER ANIMAL HEALTH GMBH [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen (DE). (72) Inventors: GRIEBENOW, Nils; Kurftirstenstr. 39, 41541 Dormagen (DE). ZHUANG, Wei; StauffenbergstraBe 13, 40789 Monheim (DE). KULKE, Daniel; Dillinger Str. 13, 51375 Leverkusen (DE). KOHLER, Adeline; Heimchen- weg 9, 40764 Langenfeld (DE). ILG, Thomas; Plotzenseer Strasse 16, 40789 Monheim (DE). WELZ, Claudia; An der Ziegelei 14, 40593 Diisseldorf (DE). SCHWARZ, Hans- Georg; Auf dem Beerenkamp 82b, 46282 Dorsten (DE). GORGENS, Ulrich; Fester Str.37, 40882 Ratingen (DE). HUBSCH, Walter; Wildsteig 22, 42113 Wuppertal (DE). KOBBERLING, Johannes; Azalienstr. 30, 41466 Neuss (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: with international search report (Art. 21(3)) (54) Title: NEW BICYCLIC PYRAZOLE DERIVATIVES 1-1 (57) : The present invention covers bicyclic pyrazole compounds of general formula (I) : in which G, A, R 1 , R , R 2 3 , and Q are as defined herein, methods of preparing said compounds, intermedi- ate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compo- sitions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.