baber/WOPTO huggingface dataset:
Patent CA-2298681-C (CA)
Title: Methods and compositions for overcoming resistance to biologic and chemotherapy
Inventor: SHEPARD H MICHAEL
IPC: C07H19/10
Filed: 1998-08-07
Granted: 2008-07-08
Abstract: This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expression as a result of selection by biologic or chemotherapy. This invention also provides methods and examples of molecules for selectively killing a pathological cell by contacting the cell with a prodrug that is a selective substrate for an endogenous, intracellular enzyme. The prodrug is subsequently converted to a cellular toxin. Futher provided by this invention is a method for treating a pathology characterized by pathological, hyperproliferative cells in a subject by administering to the subject a prodrug that is a selective substrate for an endogenous, overexpressed, intracellular enzyme, and converted by the enzyme to a cellular toxin in the hyperproliferative cell.
Patent CA-2299080-C (CA)
Title: Fluorescent tracer dyes
Inventor: FRISWELL MICHAEL ROBERT
IPC: C10M133/40
Filed: 2000-02-22
Granted: 2005-05-10
Abstract: A dye composition has the formula: (see formula I) where R1 and R2 are the same or different and are selected from (A) C2-C12 alkyloxyalkyl, and (B) C9-12alkyl, (A) comprising from about 30 to 80 mole % of the R groups, (B) comprising 20 to about 70 mole % of the R groups. The dye composition is useful as a fluorescent tracer in refrigerant lubricants of the polyol ester types used in non-Freon refrigerants.
Patent CA-2299382-C (CA)
Inventor: DEUERLING WILLI
IPC: H01B19/00
Filed: 1998-07-29
Granted: 2005-11-08
Abstract: L'invention vise à perfectionner un procédé pour la fabrication d'isolateurs type parapluie en plastique comportant une partie centrale se présentant sous la forme d'un corps plein ou creux et à laquelle sont reliés des éléments type parapluie, de manière à assurer un démoulage parfait de ces derniers malgré la formation d'un vide dans le moule lors du processus de démoulage. A cet effet, le moule (5) est utilisé avec au moins une soupape (8) disposée latéralement et atteignant la surface (4.2) de l'élément type parapluie ou de la manchette (4). Immédiatement après le début ou bien au cours du mouvement d'éloignement axial du moule (5) par rapport à l'élément type parapluie (3) avec sa manchette (4), un milieu gazeux est introduit automatiquement dans la cavité (9) se formant entre la partie centrale (2) et l'élément type parapluie (3) avec sa manchette (4) d'une part et le moule (5) d'autre part, ou bien la soupape (8) s'ouvre sous l'effet d'une traction ou d'une pression et le milieu gazeux est ainsi introduit dans la cavité (9).
Patent CA-2301039-C (CA)
Title: Cement-free refractory castable system for wet process pumping/spraying
Inventor: BONSALL SAMUEL B III
IPC: F27D1/16
Filed: 1998-08-12
Granted: 2004-04-06
Abstract: A method of applying a cement-free refractory castable to the surface of a refractory structure, comprising the steps of: a) preparing an intimately mixed refractory castable having alumina aggregate and a cemen t- free binder comprised of hydratable alumina; b) conveying the refractory castable under pressure through a delivery hose to a dispensi ng nozzle for applying the refractory castable; and c) adding a salt solution to the refractory castable prior to application by the nozzle at a rate wherein the salt solution comprises about 0.2 % to 0.9 % by weight of the refractory castable applied by the dispensing nozzle.</SDOA B>
Patent CA-2303225-C (CA)
Title: Polypeptide de l'adn 30942, un homologue du tnfr
Inventor: ASHKENAZI AVI J
IPC: C12N5/10
Filed: 1998-09-18
Granted: 2015-03-31
Abstract: On décrit un homologue du TNFR identifié sous le nom de DcR3 ainsi que des molécules d'acide nucléique codant DcR3, des molécules et des anticorps chimères dirigés contre DcR3.
Patent CA-2303778-C (CA)
Inventor: SILAS RICK
IPC: C03C27/12
Filed: 2000-04-06
Granted: 2009-05-26
Abstract: A process for bending tempered glass. The process involves adhering two sheets of tempered glass in overlying relation and positioning a containment barrier such as vinyl sheets over the adhered unit. The glass is fractured and the unit manipulated into a desired shape. Once the adhesion has set, the vinyl is removed.
Patent CA-2311492-C (CA)
Inventor: AGSTERIBBE ETIENNE
IPC: A61K39/39
Filed: 1998-11-24
Granted: 2011-10-18
Abstract: L'invention porte sur un vaccin comportant au moins un immunogène particulaire et une quantité additionnelle de la sous-unités B de l'entérotoxine thermolabile, caractéristique du E.coli. Elle porte plus particulièrement sur des vaccins dont le LTB additionnel est exempt de sous-unités A ou d'holotoxines contaminantes. On utilise de préférence à cet effet du LTB obtenu par recombinaison d'ADN. L'immunogène particulaire peut par exemple être apparenté à des virus, des bactéries ou des champignons ou en dériver. Ledit vaccin est particulièrement indiqué pour susciter une réponse protectrice contre l'immunogène particulaire lorsqu'il est appliqué sur les muqueuses (par exemple par voie intra-nasale). On a découvert qu'une telle administration assure à la fois une protection systémique et des muqueuses contre l'élément pathogène apparenté à l'immunogène particulaire.
Patent CA-2313221-C (CA)
Title: Mannich dispersants with enhanced lubricity
Inventor: HENLY TIMOTHY J
IPC: C08L91/00
Filed: 2000-06-30
Granted: 2004-06-22
Abstract: Reaction products of i) a compound containing at least one primary or secondary amine group and at least one hydroxyl group; ii) a polyamine containing at least two amine groups wherein at least one of the amine groups is a primary or secondary amine, and wherein component ii) is different from i); iii) an alkyl-substituted hydroxyaromatic compound, and iv) an aldehyde, provide improved detergency as well as improved lubricity to hydrocarbon fuels. Compositions comprising a hydrocarbon fuel and the reaction products are also disclosed.
Patent CA-2314865-C (CA)
Inventor: HOKASE MASANOBU
IPC: A61P43/00
Filed: 1998-12-18
Granted: 2003-09-23
Abstract: The present invention provides a novel method for preventing and treating mastitis in mammals and a composition for use in the method to prevent reduction in milk production caused by development of mastitis among livestock such as dairy cows, the invention being based on the finding that mastitis in mammals can be prevent ed and treated by administering phytase to the mammals.
Patent CA-2322008-C (CA)
Inventor: SCHINAZI RAYMOND F
IPC: A61K31/506
Filed: 1999-02-25
Granted: 2011-06-28
Abstract: L'invention concerne des composés de 2'-fluoro-nucléoside qui sont utiles dans le traitement d'infections par le virus de l'hépatite B, d'infections par le virus de l'hépatite C, de prolifération cellulaire anormale et due au VIH, notamment de tumeurs et de cancer. Les composés sont représentés par les formules générales (I), (II), (III) et (IV), dans lesquelles: la base est une base purique ou pyrimidique; R?1¿ est OH, H, OR?3¿, N¿3?, CN, halogène, notamment F, ou CF¿3?, alkyle inférieur, amino, alkylamino inférieur, dialkylamino inférieur, ou alkoxy, et la base se réfère à une base purique ou pyrimidique; R?2¿ est H, phosphate, notamment monophosphate, diphosphate, triphosphate ou un promédicament de phosphate stabilisé; acyle, ou un autre groupe partant pharmaceutiquement acceptable, qui, lorsqu'il est administré in vivo, est capable de produire un composé dans lequel R?2¿ est H ou phosphate; ester de sulfonate, notamment alkyle ou arylalkyle sulfonyle, notamment méthanesulfonyle, benzyle, le groupe phényle étant éventuellement substitué par un ou plusieurs substituants tels que décrits dans la définition d'aryle donnée plus haut, lipide, acide aminé, peptide ou cholestérol; et R?3¿ est acyle, alkyle, phosphate ou un autre groupe partant pharmaceutiquement acceptable, qui, lorsqu'il est administré in vivo, peut être coupé du composé d'origine, ou un sel pharmaceutiquement acceptable de celui-ci.
Patent CA-2323450-C (CA)
Title: Dosage biologique de complexe d'igfbp
Inventor: KHOSRAVI M JAVAD
IPC: G01N33/74
Filed: 1999-03-08
Granted: 2005-02-08
Abstract: L'invention concerne une méthode de dosage biologique du statut de l'hormone de croissance d'un individu par dosage immunologique du complexe ternaire de facteur de croissance de substances apparentées à l'insuline de 150 KDa (IGF/IGFBP-3/ALS). Dans un autre mode de réalisation, on peut effectuer un dosage biologique d'un complexe binaire. La méthode consiste à capturer le complexe d'IGFBP (protéines de liaison de facteur de croissance de substances apparentées à l'insuline) avec un premier anticorps couplé à une phase solide et à détecter le complexe avec un deuxième anticorps couplé à un marqueur. L'invention concerne également un ensemble d'anticorps monoclonaux et polyclonaux s'utilisant pour le dosage.
Patent CA-2324001-C (CA)
Title: Retinoid-like compounds for the promotion of melanin production
Inventor: RUNGTA DEEPA
IPC: A61Q19/02
Filed: 1999-05-06
Granted: 2007-08-07
Abstract: An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.
Patent CA-2324265-C (CA)
Inventor: CHERN REY T
IPC: B32B5/00
Filed: 1999-03-18
Granted: 2008-08-05
Abstract: Selon cette invention, on réalise la libération contrôlée de substances bioactives hydrophobes in vivo sur une durée prolongée et sans libération du médicament "en rafales" à l'aide d'une composition polymère liquide comprenant un polymère tel qu'un copolymère poly(lactide-co-glycolide) dans un mélange de solvants hydrophiles et lipophiles.
Patent CA-2325066-C (CA)
Title: Silo granular feed distribution and ladder chute apparatus
Inventor: COOK WILLIAM H JR
IPC: B65G11/08
Filed: 2000-11-02
Granted: 2005-06-14
Abstract: A granular feed distribution and ladder chute apparatus for use within a silo comprising a ladder chute portion with internal alternating and staggered flights. One or more nozzles are located near the upper end of the ladder chute portion. Each nozzle is directed such that a spray pattern may be formed for spraying a concentration of a conditioning agent on a falling granular feed.  Predetermined selected flights include cut-out portions arranged in a predetermined alternating sequence on the flights so that a distributed portion of the granular feed can fall directly through the cut-out portion in one flight onto another flight located on a same side from which the granular feed fell. Holes are included in the ladder chute portion, which not only as access for cleaning and inspecting the flights, but also for facilitating the distribution of granular feed into an area outside the perimeter of the ladder chute portion and within the silo. A transition in cooperative engagement with the upper end of the ladder chute portion is preferably included. The bottom section of the transition portion is configured with an internally directed crowned section to facilitate the spreading of the granular feed into the ladder chute.
Patent CA-2329724-C (CA)
Inventor: SRINIVASAN RAMESH
IPC: C09K21/14
Filed: 1999-04-19
Granted: 2005-06-07
Abstract: A nonwoven fabric with UV stability and flame retardancy having at least one fabric layer. The fabric layer is made of a base resin, preferably polyolefinic, and a non-halogenated melt processable compound that is selected from the group consisting of N-alkyoxy amines and are combined into a homogeneous blend which is then either spunbonded or meltblown to form the fabric layer. A melt processable fluorochemical additive may also be combined into the homogeneous blend to provide liquid barrier properties to the fabric layer.
Patent CA-2330181-C (CA)
Inventor: LEWIS RONALD A
IPC: F24B1/20
Filed: 2001-01-03
Granted: 2002-06-25
Abstract: Cooking apparatus comprises an elongated post supportable in an upright position in proximity to a cooking fire, a collar slidably mounted on the post for sliding movement along the post; a cooking platform secured to the collar, a tether, and a link engaging mechanism carried at the upper end of the post. At least a portion of the tether is a link chain. The link engaging mechanism serves to releasably secure the collar together with the platform at a selected position of elevation on the post. In order to control the cooking process, the apparatus may be structured not only to control the elevation of the cooking platform over the cooking fire but also to control the horizontal angular position of the cooking platform in relation to the cooking fire. A cooking platform having a rectangular perimeter may be mounted to the collar near a corner of the perimeter to achieve a practical balance between the cooking area or area of reach of the platform and the tipping moment force of the platform on post.
Patent CA-2333336-C (CA)
Title: Lock handle assembly for casement windows
Inventor: CHIAIA JOHN A
IPC: E05C9/02
Filed: 2001-01-31
Granted: 2007-09-18
Abstract: A lock handle assembly for a multi-point casement window is disclosed. The lock handle assembly includes an escutcheon for mounting to the inside surface of the frame.  The escutcheon includes an elongated body which features an inner side facing away from the inside surface of the frame and an outer side that extends through the inside surface of the frame. The escutcheon further includes an elongated slot for receiving a handle through the inner side of the escutcheon. The slot comprises an upper end and a lower end defined by upper and lower walls respectively. The handle is pivotally connected to the escutcheon by a shaft having an axis that extends transversely through the slot. The shaft further connects a movable link to the handle. The shaft also passes through a fixed gear which is secured to the escutcheon. The fixed gear includes an arcuate gear. The movable link includes a proximal end pivotally connected to the shaft in a distal end pivotally connected to a drive gear link. The drive gear link includes a distal end pivotally connected to a movable link and a proximate end including an arcuate gear enmeshed with the arcuate gear of the fixed gear. The distal end of the drive gear link also is pivotally connected to the connecting link at a connecting axis. This design enables the handle to undergo a relatively short range rotation ranging from about 100° to about 140° while moving the connecting axis through an arcuate path defined by an angle ranging from about 140° to about 180°. The handle and escutcheon present a relatively low profile on the inside surface of the sash.
Patent CA-2340934-C (CA)
Inventor: WAKAMIYA NOBUTAKA
IPC: C07K14/47
Filed: 1999-08-24
Granted: 2009-02-17
Abstract: L'invention concerne de nouvelles molécules liées à la collectine, exerçant une activité antibactérienne et antivirale, en particulier, chez l'homme. L'invention traite plus particulièrement d'un nouveau gène de collectine contenant la séquence de base représentée par SEQ ID NO:1 et une nouvelle collectine contenant la séquence d'acides aminés représentée par SEQ ID NO:2. L'invention a aussi pour objet un procédé mettant en oeuvre ces composés.
Patent CA-2347622-C (CA)
Inventor: RADER RICHARD SCOTT
IPC: G01T1/164
Filed: 1999-10-21
Granted: 2009-05-19
Abstract: A radiation detection apparatus (10) having a handheld radiation detection probe (50) with a switch assembly (70) removably mounted thereon. The switch assembly has first and second switches, one switch (72) to initiate transmission of electrical signals representing scintillations detected over a set time period to a remotely located control unit (100) for counting and averaging, and the other switch (74) to direct the control unit to download and preferably record the counted and averaged scintillation values for further use.
Patent CA-2348361-C (CA)
Inventor: SCOTT DANIEL G
IPC: B60T8/18
Filed: 2001-05-24
Granted: 2005-10-11
Abstract: A pneumatic pressure control device for an empty/load changeover valve on a railway car, which enables an empty/load changeover valve to have a lower profile. The pneumatic pressure control device comprises a mounting member having a first surface, a second surface, and further having an actuating push rod. A sensor arm of a predetermined size and shape has a first end and a second end. A first means disposed adjacent at least one of the first surface and the second surface of the mounting member pivotally supports the sensor arm in a predetermined position on the mounting member. A second means is engageable with the sensor arm and the actuating push rod on the mounting member for moving the push rod in response to a movement of the sensor arm. A load sensing means has at least a portion thereof disposed on the second end of the sensor arm for determining a rate of brake cylinder pressure required relative to an actual weight of a railway car. The sensor arm and the load sensing means have a predetermined travel limit.
Patent CA-2349365-C (CA)
Inventor: KELLER DOUGLAS O
IPC: B02C18/14
Filed: 1999-11-18
Granted: 2008-04-22
Abstract: An improved knife holder (10) for a chipper disc. A knife holder (10) for holding a knife has a first clamping portion (14) and a second clamping portion (16) for clamping the knife therebetween. One of the clamping portions (16) pivots about a pivot point (22) for clamping the knife and for releasing the knife so that it may be easily removed from the knife holder. In the relative position of the clamping portions in which the knife (12) is clamped and in their relative positions in which a space is opened up around the knife permitting its removal, the clamping portions are rigidly disposed with respect to one another.
Patent CA-2350439-C (CA)
Inventor: HARTMANN-SIANTAR CHRISTINE L
IPC: A61N5/10
Filed: 1999-11-02
Granted: 2005-08-02
Abstract: Cette invention se rapporte à un système et à un procédé permettant de calculer des doses de rayonnement à l'intérieur de sous-volumes d'une grille de transport de particules. Ce procédé consiste: dans une première étape, à recevoir les volumes de voxels renfermant une première partie de la masse cible; dans une deuxième étape, à définir des volumes dosels qui renferment une seconde partie de la masse cible et chevauchent la première partie; dans une troisième étape, à calculer des volumes communs entre les volumes de dosels et les volumes de voxels; dans une quatrième étape, à identifier les positions dans la masse cible de dépôts d'énergie; et, dans une cinquième étape, à calculer les doses de rayonnement reçues par la masse cible à l'intérieur des volumes de dosels.
Patent CA-2361725-C (CA)
Title: Selection de proteines par fusions de proteines et d'arn
Inventor: SZOSTAK JACK W
IPC: C07K2/00
Filed: 2000-02-01
Granted: 2011-04-12
Abstract: La présente invention concerne des méthodes de fusion de protéines et d'ARN comprenant une étape d'incubation post-traductionnelle en présence d'une teneur élevée en sels.
Patent CA-2362277-C (CA)
Inventor: MATTHEWS GRAHAM PAUL
IPC: A61K9/107
Filed: 2000-02-14
Granted: 2010-03-30
Abstract: Spontaneously dispersible N-benzoyl-staurosporine compositions are discussed for oral administration having high bioavailability levels and reduced variability of bioavailability levels of N-benzoyl-staurosporine, as well as their preparation and use in medical treatment.
Patent CA-2367694-C (CA)
Inventor: SELMAN BYRON
IPC: A61K35/16
Filed: 2000-03-15
Granted: 2008-08-05
Abstract: A filter device (100) comprising a filter (10) for producing a leukocyte- depleted plasma-rich fluid is disclosed.
Patent CA-2370432-C (CA)
Inventor: AUDIGIE JEAN-CHARLES
IPC: A01C7/04
Filed: 2002-02-05
Granted: 2008-06-03
Abstract: The seeder comprises a dosing device (4) driven by a mechanism (10) provided with an input shaft, a pinion and a control handle which rotates with the shaft.
Patent CA-2370490-C (CA)
Title: Battery, tab of battery and method of manufacture thereof
Inventor: YAMASHITA RIKIYA
IPC: H01M50/534
Filed: 2001-04-18
Granted: 2009-04-07
Abstract: A lithium ion battery (1) comprises a battery body (2) with tabs (4), and a package (5) containing the battery body (2). The package (5) has a heat-sealed edge (5a). The tabs (4) has chemical conversion coating (4S) in their portions corresponding to the edge (5a).
Patent CA-2370834-C (CA)
Inventor: EMONDS-ALT XAVIER
IPC: A61P25/18
Filed: 2000-04-25
Granted: 2007-09-25
Abstract: The invention relates to the use of saredutant and the pharmaceutically acceptable salts thereof to produce medicaments that are used to treat or prevent mood disorders, adjustment disorders or mixed anxiety-depression disorders.
Patent CA-2373922-C (CA)
Title: Waterborne primer with improved chip resistance
Inventor: KANDOW TIMOTHY
IPC: B32B27/00
Filed: 2000-08-21
Granted: 2008-03-18
Abstract: The invention provides a thermosetting aqueous primer composition that includes a polyurethane polymer, an acrylic polymer, and a crosslinking component that is reactive with at least one of the polyurethane polymer and the acrylic polymer. The polyurethane polymer has a glass transition temperature of O°C or less.  The acrylic polymer has a glass transition temperature that is at least about 20°C higher than the glass transition temperature of polyurethane resin. The invention further provides a composite coating having as a primer layer a cured layer of the primer composition of the invention and having at least one topcoat layer.
Patent CA-2375310-C (CA)
Inventor: STRAY JENS
IPC: B67D3/00
Filed: 2000-02-28
Granted: 2004-07-13
Abstract: The invention relates to an adapter for use in connection with combined coolers and dispensers for liquids, particularly drinking water, which coole rs and dispensers are intended for receiving a bottle-shaped container placed bottom-up on the top of the combined cooler and dispenser. The adapter comprises a support for supporting a container for a liquid, a chamber extending downwardly from the support, said chamber having an opening in its wall, a lower part with a bottom, a vertical pipe arranged in the bottom of the lower part of the adapter, which pipe is open or can be opened at its lower end and is closed at its upper end and which at its upper part has a flange which is open towards the inside of the pipe, said flange being intended to be connected to a flexible hose between the flange and the container which is to be placed in the adapter and where the vertical pipe i s intended to communicate with the pipe system in the combined cooler and dispenser.
Patent CA-2376525-C (CA)
Inventor: COUILLARD HARLAND D
IPC: C04B41/53
Filed: 2002-03-14
Granted: 2009-09-15
Abstract: An apparatus for removing a forming element from a concrete pipe includes a support member and a removal device including first and second elements. The first element is attachable to the forming element and has a stop. The second element is supported by the support member such that the second element is swingable with respect to the support member. In addition, the second element is engageable with the stop so as to apply a force to the first element for removing the forming element from the concrete pipe.