Patent EA-004868-B1 (EA)
Title: Sulfonamide derivatives
Inventor: AIKINS JAMES ABRAHAM
IPC: C07C311/03
Filed: 2001-05-04
Abstract: 1. A compound of the formula: or a pharmaceutically acceptable salt thereof. 2. A compound of the formula: 3. A composition comprising a compound of the formula: or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier, diluent or excipient. 4. A method of potentiating glutamate receptor function in a patient, which comprises administering to said patient an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. 5. A method of treating depression in a patient comprising administering to said patient an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. 6. A method of treating schizophrenia in a patient comprising administering to said patient an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. 7. A method of treating cognitive disorders in a patient comprising administering to said patient an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. 8. A process for the preparation of a compound of formula Ia: comprising, nitrating a sulfonamide (5): to provide a p-nitro derivative (6): hydrogenating the p-nitro derivative (6) to provide a p-amino derivative (7): treating the p-amino derivative (7) with a suitable acid, then treating with a suitable base, and then treating with 3,5-difluorobenzoyl chloride. 9. An article of manufacture comprising packaging material and a compound of formula: or a pharmaceutically acceptable salt thereof contained within said packaging material, wherein said packaging material comprises a label which indicates that said compound can be used for treating at least one of the following; Alzheimer's disease, schizophrenia, cognitive deficits associated with schizophrenia, depression, and cognitive disorders. 10. An article of manufacture according to claim 9 wherein said label indicates that said compound can be used for treating Alzheimer's disease. 11. An article of manufacture according to claim 9 wherein said label indicates that said compound can be used for treating schizophrenia. 12. An article of manufacture according to claim 9 wherein said label indicates that said compound can be used for treating depression. 13. An article of manufacture according to claim 10 wherein said label indicates that said compound can be used for treating cognitive deficits associated with schizophrenia. 14. Use of a compound of formula: for the manufacture of a medicament for potentiating glutamate receptor function. 15. Use of a compound of formula: for the manufacture of a medicament for treating Alzheimer's disease. 16. Use of a compound of formula: for the manufacture of a medicament for treating schizophrenia. 17. Use of a compound of formula: for the manufacture of a medicament for treating cognitive deficits associated with schizophrenia. 18. A compound of formula: or a pharmaceutically acceptable salt thereof for potentiating glutamate receptor function. 19. A compound of formula: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for potentiating glutamate receptor function.