baber/WOPTO huggingface dataset:
Patent RU-2273645-C9 (RU)
Inventor: FRIEDMAN JEFFREY M
IPC: A61K38/16
Filed: 1995-08-17
Granted: 2006-11-27
Abstract: FIELD: biotechnology, molecular biology, medicine. 
     SUBSTANCE: invention discloses amino acid sequences of human obesity polypeptide (OB) two isoforms possessing capacity for modulation of animal body mass, their signal peptide-containing precursors and analogues. Polypeptide isoforms are prepared as result of insertions, deletions and amino acid changes that retain activity typical for nonmodified forms of OB-polypeptides, and polyclonal and monoclonal antibodies interaction specifically with new agents modulating the body mass value also. Invention describes DNA sequences encoding these polypeptides and their analogues, vector structures comprising these sequences used for preparing recombinant forms of OB-polypeptides. Invention proposes using new polypeptides and their analogues as an active component in pharmaceutical compositions. Using this invention can promote to solving the problem for providing medicine, veterinary science and animal husbandry with effective agent used for decreasing the body mass value. Invention can be used in medicine for diagnosis and treatment of pathological states associated with disturbance of regulation of human body mass, and in animal husbandry and veterinary science. 
     EFFECT: valuable biological, medicinal and veterinary properties of polypeptide. 
     23 cl, 71 dwg, 12 tbl, 17 ex
Patent RU-2652225-C9 (RU)
Title: Подложка для защищенных бумаг и способ ее изготовления
Inventor: SCHAEDE JOHANNES GEORG
IPC: D21H21/40
Filed: 2014-02-17
Granted: 2018-06-15
Abstract: Изобретение относится к подложке для защищенных документов, таких как банкноты, и способу ее изготовления. Указанная подложка (S) содержит один или более бумажных слоев (11, 12) и полимерный слой (20), выполненный с возможностью приклеивания к стороне по меньшей мере одного из бумажных слоев (11, 12). Полимерный слой (20) является по существу прозрачным по меньшей мере в одной области подложки (S), которая не покрыта одним или более бумажными слоями (11, 12), для образования, таким образом, в подложке (S) по существу прозрачного окна (W), которое образовано и закрыто полимерным слоем (20). Полимерный слой (20) имеет в области окна (W) толщину (Т), которая больше толщины (t) полимерного слоя (20) вне области окна (W). Толщина (Т) полимерного слоя (20) в области окна (W) по существу равна сумме значений толщины бумажного слоя или слоев (11, 12) и полимерного слоя (20) вне области окна (W), так чтобы у подложки (S) была по существу равномерная и постоянная толщина (Т). Подложка (S) также содержит микрооптическую структуру (30), в частности линзовую структуру, которая находится в области окна (W) по меньшей мере на одной стороне полимерного слоя (20). Изобретение обеспечивает защищенные документы с усиленными динамическими и/или оптикопеременными эффектами и повышение их степени защиты. 2 н. и 18 з.п. ф-лы, 6 ил.
Patent RU-2749156-C9 (RU)
Title: Способ получения адгезивной культуры нейральных стволовых/прогениторных клеток обонятельной выстилки носа млекопитающих для лечения травм спинного мозга
Inventor: CHEKHONIN VLADIMIR PAVLOVICH
IPC: C12N5/079
Filed: 2020-07-23
Granted: 2021-08-03
Abstract: Изобретение относится к области биотехнологии и медицины. Заявлен способ получения адгезивной культуры нейральных стволовых/прогениторных клеток из обонятельной выстилки носа млекопитающих для лечения травм спинного мозга, включающий получение образца ткани из обонятельной выстилки носа млекопитающего с последующей промывкой и инкубированием в течение 1 ч при 37°С с 3,6 ед./мл диспазы II, затем ткань обонятельного эпителия механически отделяют от собственной пластинки в среде DMEM:F12(1:1) с антибиотиками и инкубируют с раствором 500 ед./мл коллагеназы в течение 10 мин при 37°С, инактивируют фермент средой с сывороткой, ресуспендируют, центрифугируют 2 мин при 900 g, клетки помещают на пластик и культивируют в течение 5 дней в среде DMEM:F12(1:1), содержащей 10% FBS, 2 мМ L-глутамина и антибиотики, среду заменяют каждые два дня, образованный монослой клеток обонятельного эпителия снимают с помощью 0,25% раствора трипсина, помещают на пластик, покрытый 50 мкг/мл фибронектином, культивируют 1-2 дня в нейробазальной среде, содержащей 2 мМ L-глутамина, 1% ITS, 2% В27, 100 мкг/мл стрептомицина, 100 ед./мл пенициллина, 60 мкг/мл гентамицина, 50 нг/мл bFGF, 50 нг/мл EGF, полученные клетки охарактеризовывают по маркерам нестин и βIII-тубулин. Изобретение обеспечивает получение адгезивной культуры, обогащенной нейральными стволовыми/прогениторными клетками с повышенной выживаемостью в достаточном для дальнейшей трансплантации количестве. 3 з.п. ф-лы, 14 ил., 5 пр.
Patent DK-12190-D0 (DK)
Inventor: SENN-BILFINGER JOERG
IPC: A61K31/435
Filed: 1990-01-15
Abstract: PCT No. PCT/EP88/00638 Sec. 371 Date Jan. 16, 1990 Sec. 102(e) Date Jan. 16, 1990 PCT Filed Jul. 14, 1988 PCT Pub. No. WO89/00570 PCT Pub. Date Jan. 26, 1989.Compounds of formula I,   <IMAGE> (I) wherein the substituents and symbols having the meanings stated in the description are new compounds having interesting pharmacological properties. They have a protective effect on the stomach and intestine in warm-blooded animals.
Patent DK-26686-D0 (DK)
Inventor: BROWN THOMAS HENRY
IPC: C07D285/10
Filed: 1986-01-20
Abstract: Compounds of the formula (I) :- 
<CHEM>
 or pharmaceutically acceptable salts are described, wherein R<1> and R<2> are independently hydrogen or C1-6alkyl, or R<1> and R<2> together represent -(CH2)q- wherein q is 4 to 7, to form together with the nitrogen atom to which they are attached, a 5-8 membered saturated ring, optionally substituted by C1-6alkyl;  X is -CH2- or sulphur; n is 2 or 3, or if X is -CH2- n can also be 1; p is 1 or 2; and R<3> is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl (wherein the unsaturated bond is not adjacent to the -NH- moiety). 
<??>The compounds are histamine H2-receptor antagonists and are useful in treating diseases mediated via histamine H2-receptors. Processes for their preparation, pharmaceutical compositions containing them and methods of use are described.
Patent DK-45284-D0 (DK)
Inventor: WOLFF-MOOIJ MARCELLE NELLY
IPC: A61M25/00
Filed: 1984-02-01
Abstract: A connector assembly for sterile connection of two internally sterile containers or tubings comprises two connectors (3, 4). The first connector (3) has a male part (5) inside a housing (6), a connecting device to connect the first connector to a first container or tubing (1), a first deformable barrier (7) spaced from the male part (5) and a chamber (8) between the male part (5) and the first barrier (7). The second connector (4) comprises a female part (9), a connecting device to connect the second connector to a second container or tubing (2) and a second deformable barrier (11) closing the female part (9). In connecting the connectors (3, 4) first both deformable barriers (7,11) are brought into contact with each other after which the male part (5) of the first connector (3) is put through the second barrier (11) closing the female part (9) of the second connector (4). To guarantee that during each coupling and disconnecting procedure the absolute sterility of the interior of the female part is maintained the second barrier (11) is mounted in the entrance part of the female part (9) and is pushed entirely through the first barrier (7) during the connection of the connectors (3, 4) into the chamber (8) between the male part (5) and the first barrier (7) before the male part (5) can penetrate the second barrier (11). Further at least the second barrier (11) consists of a resilient material which during the disconnecting procedure of the connectors will be restored in the chamber (8) into the original closing position.
Patent DK-96691-D0 (DK)
Inventor: CAMPION COLIN
IPC: A61K31/21
Filed: 1991-05-22
Abstract: Compounds of general formula I:    <IMAGE>  (I)  wherein: R1 represents a C1-C6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C1-C6)alkyl, heterocyclyl, (C1-C6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R1 represents SRx, wherein Rx represents a group:   <IMAGE>   R2 represents a hydrogen atom or a C1-C6 alkyl, C1-C6 alkenyl, phenyl(C1-C6)alkyl, cycloalkyl(C1-C6)alkyl or cycloalkenyl(C1-C6)alkyl group; R3 represents an amino acid residue with R or S stereochemistry or a C1-C6 alkyl, benzyl, (C1-C6 alkoxy)benzyl or benzyloxy(C1-C6 alkyl) group; R4 represents a hydrogen atom or a C1-C6 alkyl group; R5 represents a hydrogen atom or a methyl group; n is an integer having the value 0, 1 or 2; and A represents a C1-C6 hydrocarbon chain, optionaly substituted with one or more C1-C6 alkyl, phenyl or substituted phenyl groups; and their salts and N-oxides are collagenase inhibitors are and useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumor invasion.
Patent DK-154688-D0 (DK)
Inventor: BOURSON LUCIEN
IPC: D21H23/00
Filed: 1988-03-22
Abstract: 1. Process for the manufacture of wrapping paper and of cardboard, characterized in that the following are added to the suspension containing the cellulose fibres before the sheet is formed : a) more than 0.5 parts by weight of cationic starch per 100 parts of cellulose fibres, b) less than 1 part by weigth, expressed as Al2 O3 , of aluminium polychloride per 100 parts of cellulose fibres.
Patent DK-175490-D0 (DK)
Inventor: ISSERSTEDT ROBERT K
IPC: B42F7/08
Filed: 1990-07-23
Abstract: A portable filing device comprises a bag which can be opened out to be flat, a hook for suspending the bag, a spine extending across the bag, two straps hanging from the ends of the spine, and a series of hanging pouches spaced along the straps. Each pouch is attached to the straps at the ends of its top edge, and has an aperture along its top edge. The pouches are detachable. For transportation, the pouches are gathered into a stack, with the straps forming concertina folds, and the bag is folded around the stack and fastened shut. The device, among other applications, enables travellers to keep papers and belongings in order. A labelling means comprises an elongate stiffly flexible label or label holder which by bowing can be inserted in or removed from an undercut seating.
Patent DK-374588-D0 (DK)
Inventor: SPATZ GUENTER
IPC: B65D41/34
Filed: 1988-07-06
Abstract: The circular cap (1), preferably consisting of lightweight metal or plastic, has a circumferential inwardly beaded skirt (4) which overlaps the webs (2) of the securing ring (3). <IMAGE>
Patent DK-377785-D0 (DK)
Inventor: BISCHOFF EDELBERT
IPC: G01N31/22
Filed: 1985-08-20
Abstract: 1. Process for detecting the presence of allergencontaining house dust such as is produced during or after the appearence of house dust mites, in which samples of dust appearing in buildings are thoroughly suspended in aqueous-alcoholic alkali metal hydroxide solution, and a colour reaction is carried out with the resulting extract using an aromatic diazo compound, characterized in that in order to evaluate the allergological activity of the dust sample, quantitative measurement of the colour intensity of the colour reaction is carried out.
Patent DK-438885-D0 (DK)
Inventor: GROHE KLAUS
IPC: C07C211/00
Filed: 1985-09-27
Abstract: Novel 3-amino-2-benzoyl-acrylic acid derivatives of the formula <IMAGE>   in which R1 represents the nitrile group, an ester group -COOR4 or carboxamide group   <IMAGE>  R4 denoting C1-C6-alkyl, and R5 and R6 representing hydrogen or C1-C3-alkyl or phenyl, R2 and R3, which can be identical or different, represent a C1-C6-alkyl radical and, furthermore, can form, together with the nitrogen atom to which they are bonded, a 5- or 6-membered heterocyclic ring which can additionally contain as ring member the atoms or groups -O-, -S-, -SO- or -SO2-, X represents halogen, X1 denotes hydrogen, methyl, nitro or halogen, X2 denotes halogen or methyl, and X3 denotes hydrogen or halogen, are prepared by reacting    <IMAGE>  The products can be converted into known antibacterials.
Patent DK-485185-D0 (DK)
Inventor: KLUEPPEL HANS-JUERGEN
IPC: A61K8/55
Filed: 1985-10-22
Abstract: Oral and dental preparations containing as an active ingredient an anti-caries effective amount of a C2-4 alkoxylated trihydric to hexahydric C3-12 aliphatic polyol wherein at least one hydroxyl moiety is esterified with phosphoric acid, or a physiologically compatible water soluble salt thereof.
Patent DK-605984-D0 (DK)
Inventor: OTT HANS
IPC: B41F33/00
Filed: 1984-12-18
Abstract: A color measuring strip having a plurality of different measuring fields includes information codes located either laterally adjacent to, or between, individual measuring fields. The information codes are individually assigned to respective measuring fields, and contain information relating to such items as scanning position and the color and type of the field concerned. The information codes are machine-read and are evaluated so that a scanning head may be positioned relative to the measuring fields, and are further used in processing the data provided by the scanning head.
Patent DK-631186-D0 (DK)
Inventor: DAMM STURE
IPC: D06P5/00
Filed: 1986-12-29
Abstract: Method for dyeing of cellulose fibers by means of reactive dyeing agents according to the exhaust method. According to the present method one adds the alkali necessary for the fixation of the dyeing agent continuously or substantially continuously over a predetermined time interval so, that an adding process with predetermined progression is not brought to the end, but after a predetermined time is followed by an addition process with a different progression.
Patent HU-9301454-D0 (HU)
Title: Amino-pyrimidine derivatives of insecticidal, acaricidal and fungicidal effect
Inventor: DRUMM JOSEPH EUGENE
IPC: A01N55/00
Filed: 1991-11-13
Abstract: PCT No. PCT/US91/08241 Sec. 371 Date May 13, 1993 Sec. 102(e) Date May 13, 1993 PCT Filed Nov. 13, 1991 PCT Pub. No. WO92/08704 PCT Pub. Date May 29, 1992.Compounds of the formula:   <IMAGE>   wherein A, Q and R2 to R5 are as defined in the text, compositions containing them and methods for using them to control insects, acarids and fungi.
Patent HU-904091-D0 (HU)
Title: Process and apparatus for producing nitrogen
Inventor: KAMRATH DAVID J
IPC: F25J3/08
Filed: 1990-07-04
Abstract: In a nitrogen generation process in which a stream of air is compressed in compressor 11, is cooled and has water vapour and carbon dioxide removed therefrom in a reversing heat exchanger 16, and is separated in a rectification column 24, a gaseous nitrogen product stream 30 is produced. An air turbine 22 is operated to produce refrigeration for the process. The process is also used to purify merchant liquid nitrogen typically containing from 0.5 to 5 vpm of oxygen. A stream 51 of such merchant liquid nitrogen is introduced into a stage of the rectification column where the liquid nitrogen has a substantially matching composition. A stream 36 of purified liquid nitrogen is withdrawn from the top of the column 24. The purified liquid nitrogen can be produced at a rate in excess of that made possible by the turbine 22 without reducing the efficiency of gaseous nitrogen generation.
Patent HU-905147-D0 (HU)
Title: Method for manufacturing vitrified brick
Inventor: BIRKNER FRIEDRICH
IPC: C04B7/24
Filed: 1990-05-30
Abstract: PCT No. PCT/AT90/00050 Sec. 371 Date Jan. 28, 1991 Sec. 102(e) Date Jan. 28, 1991 PCT Filed May 30, 1990 PCT Pub. No. WO90/14899 PCT Pub. Date Dec. 13, 1990.In a process for the production of clinkers from sludges containing heavy metals, especially electroplating sludges, river and/or harbor sludges, in which the sludges are mixed with clay, especially brickyard clay, and optionally lean materials and fluxing materials and then are burned to clinkers especially at temperatures between 750 DEG  and 1150 DEG  C., zeolites are admixed with the sludges and the clay before the burning.
Patent NO-870347-D0 (NO)
Inventor: LANGLEY JOHN
IPC: D21H21/10
Filed: 1987-01-28
Abstract: Paper or paper board is made by passing an aqueous cellulosic suspension through a centriscreen or other shear device and then draining the purified suspension, and an improved combination of retention, drainage, drying and formation is achieved by adding to the suspension an excess of high molecular weight linear synthetic cationic polymer before shearing the suspension and adding bentonite after shearing.
Patent NO-891252-D0 (NO)
Inventor: SLEGERS JOHN
IPC: C02F1/44
Filed: 1989-03-22
Abstract: An improved method of operating a membrane separation system is provided, which comprises applying a reduced pressure to one side of the or each membrane to thereby cause fluid to be drawn through the or each membrane from the other side thereof. As the method does not utilize fluid under pressure, which has typically been required in prior art procedures, the risk of damage to the membranes is eliminated, or at least minimised.
Patent NO-891488-D0 (NO)
Inventor: ROMINE RICHARD L
IPC: C25B9/19
Filed: 1989-04-11
Abstract: A diaphragm cell cathode assembly has improved current distribution to a tube sheet (6) distributing electrical current to cathode tubes (7). Electrical current is fed to the diaphragm cell assembly by grid bars (2) connected to side plates (3). The current must then flow from the side plates (3) to the inner tube sheets (6), the tube sheets and side plates being generally in spaced apart, planar parallel relationship to one another. Assembly temperature uniformity, as well as temperature reduction, is now enhanced by providing supplemental distributor bars (11),(13), at the upper and lower regions of the grid bars, and in electrical connection between side plates and tube sheets.
Patent NO-892955-D0 (NO)
Inventor: JAMES MICHAEL HOWARD
IPC: A61B19/04
Filed: 1989-07-19
Abstract: A skin-contacting lubricating layer formed from a hydrogel polymer bonded to a rubber article (such as a surgeon's glove) is treated by means of surfactant material (such as a bactericidal cationic surfactant which preferably has a 6-18C alkyl or alkenyl group, such as an N-hexadecyl group) or a long chain fatty amine so as to substantially improve the lubricity of the layer with respect to damp skin. The hydrogel polymer is preferably a copolymer of 2-hydroxyethylmethacrylate (HEMA) with methacrylic acid (MAA) or with 2-ethylhexyl acrylate (EHA) or with both MAA and EHA. Such a hydrogel polymer has improved lubricity to dry skin and, if used for this purpose, need not be treated with a surfactant or fatty amine to improve the lubricity with respect to damp skin.
Patent NO-902304-D0 (NO)
Inventor: NARDUCY KENNETH W
IPC: C08J7/043
Filed: 1990-05-23
Abstract: There is disclosed a method for making colored hydrophilic contact lenses. A contact lens constructed of hydrophilic polymer that is substantially devoid of the functional groups -COOH, -OH, -NH-R, wherein R is hydrogen or C1 to C8 alkyl, -NCO and epoxy is provided. At least a portion of the surface of the lens is coated with a color coat comprising at least one pigment, binding polymer having functional groups selected from at least one of -COOH, -OH, and -NH-R, wherein R is hydrogen or C1 to C8 alkyl, and an additional compound having at least two groups per molecule of -NCO. The coated lens is subjected to conditions which cause the color coat to adhere to the lens.
Patent NO-904618-D0 (NO)
Inventor: TAVERNIER HERVE
IPC: B22D11/06
Filed: 1990-10-25
Abstract: The subject of the invention is a process for supplying heat, during their solidification, to the edge portions of a thin metallic product 4 continually cast on a machine comprising a casting space defined by rotating twin rolls 1, 1' and two lateral closure plates 2, 2', characterised in that a lining of consumable material 5, intended to react exothermically with the metal which comes into contact with it, is applied on the portions 9 of the cooled surface of the rolls close to the lateral closure plates. 
<??>A further subject of the invention is a roll for a continuous-casting machine, adapted for this usage, and a continuous-casting installation for implementing this process. 
<IMAGE>
Patent NO-921335-D0 (NO)
Inventor: DEVIC M MICHEL
IPC: D21C9/10
Filed: 1992-04-06
Abstract: Manufacture of high-yield paper pulp from wood chips. The process consists in successively treating the chips, before grinding, with a solution containing at least one reducing agent, and then with an alkaline hydrogen peroxide solution. Application to the manufacture of paper pulp with a high degree of whiteness and good mechanical characteristics.
Patent NO-931820-D0 (NO)
Inventor: KLEBL WOLFRAM
IPC: B23K9/073
Filed: 1993-05-19
Abstract: In order to control the welding current as a function of the welding speed in the case of DC arc welding devices for continuous longitudinal-seam welding to the tube of formed metal strips, a voltage value (11), which is dependent on the welding speed, is added to an adjustable fixed voltage value (13). The sum of the speed-dependent voltage value (11) and the adjustable fixed-voltage value (15) additionally has a pulsed DC voltage value (28) superimposed on it. <IMAGE>
Patent NO-934732-D0 (NO)
Inventor: HAUSER JEAN-LUC
IPC: A61M37/00
Filed: 1993-12-20
Abstract: A perfusion system comprising an implantable access device with two separate chambers (10, 12) accessed via a septum (16, 18), said chambers being arranged one above the other so that when the infusion or sampling needle is inserted into the lower chamber (10) by passing it through the respective septum (16), said needle also passes through the septum (18) of the upper chamber (12). The system further comprises an infusion device consisting of two rigidly connected parallel needles (36, 38) having different lengths, such that when the longer needle (38) is inserted into the lower chamber, the shorter needle (36) is also inserted into the other chamber. The infusion device with two rigidly connected needles avoids any danger of tearing which may lead to extravasation.
Patent NO-940465-D0 (NO)
Inventor: ERIKSSON SVEN
IPC: B08B/
Filed: 1994-02-11
Abstract: PCT No. PCT/SE92/00082 Sec. 371 Date Feb. 16, 1994 Sec. 102(e) Date Feb. 16, 1994 PCT Filed Feb. 11, 1992 PCT Pub. No. WO93/03866 PCT Pub. Date Mar. 4, 1993.The present invention relates to a device for cleaning and/or treating elongated closed ducts or channels, particularly ventilation ducts. The device includes an automotive vehicle and mounted thereon a rotary brush useful for cleaning and/or surface treating. The rotary brush is mounted for rotation on a shaft that extends generally at right angles to the longitudinal axis of the duct. The invention also contemplates mounting a television camera onto the automotive vehicle for monitoring results of the cleaning and/or treating operation.