Patent SG-11201407189X-A (SG)
Title: C-17 bicyclic amines of triterpenoids with hiv maturation inhibitory activity
Inventor: SIN NY
IPC: A61K31/56
Filed: 2013-05-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/169578 A1 (51) International Patent Classification: C07J 63/00 (2006.01) A61P 31/18 (2006.01) A61K31/56 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/039389 3 May 2013 (03.05.2013) English (30) Priority Data: 61/643,483 13/799,479 7 May 2012 (07.05.2012) 13 March 2013 (13.03.2013) English US US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (72) Inventors: SIN, Ny; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). LIU, Zheng; c/o Bristol-Myers Squibb Company, 5 Re­ search Parkway, Wallingford, Connecticut 06492 (US). SWIDORSKI, Jacob; c/o Bristol-Myers Squibb Com­ pany, 5 Research Parkway, Wallingford, Connecticut 06492 (US). SIT, Sing-Yuen; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). CHEN, Jie; c/o Bristol-Myers Squibb Com­ pany, 5 Research Parkway, Wallingford, Connecticut 06492 (US). CHEN, Yan; c/o Bristol-Myers Squibb Com­ pany, 5 Research Parkway, Wallingford, Connecticut 06492 (US). MEANWELL, Nicholas A.; c/o Bristol-My­ ers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). REGUEIRO-REN, Alicia; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). (74) Agents: LEVIS, John F. et al.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543- 4000 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, [Continued on next page] (54) Title: C-17 BICYCLIC AMINES OF TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY Y-X Y-X 00 l> o\ Y-X (57) Abstract: Compounds having drug and bio-affecting properties, their pharma­ ceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS. Formula I WO 2013/169578 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll llll llll lllll lllllll llll llll BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))