baber/WOPTO huggingface dataset:
Patent JP-2954954-B2 (JP)
IPC: A61K31/695
Filed: 1989-12-14
Granted: 1999-09-27
Abstract: For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula  <IMAGE>  in which A is optionally substituted aryl or heterocyclic, B is optionally substituted alkyl, cycloalkyl or aryl, D and E independently are optionally substituted aryl or heterocyclic, H, nitro, cyano, optionally substituted alkyl, alkenyl or imino, amino, alkoxy or acyl, or forms a ring with B, G is O or S, X is -CH2-CH2- or -CH=CH-, and R represents a group of the formula  <IMAGE>  and salts thereof.
Patent JP-3048061-B2 (JP)
IPC: C07K1/20
Filed: 1990-11-30
Granted: 2000-06-05
Abstract: The invention relates to a process for the production of biologically active, dimeric TGF- beta , to novel TGF- beta s and pharmaceutical compositions comprising it. TGF- beta produced by this process can be used in various therapeutic modalities.
Patent JP-3697917-B2 (JP)
IPC: B62D25/20
Filed: 1998-12-11
Granted: 2005-09-21
Abstract: PROBLEM TO BE SOLVED: To provide a planer member structure for an automobile, which can ensure a clearance with respect to a high stiffness member such as an engine while ensure stiffness for a planar member. SOLUTION: At least one of an outer panel 2 and an inner panel 3 is made of a steel sheet or a light metal sheet, and dimples 4a, 4b are formed in a flat part of the planar member 3, and a high stiffness member such as a unit in a vehicle is laid on the planar member on the side where the dimples 4a, 4b are formed. The dimples 4a opposed to the high stiffness member is shallower than the dimples 4b which is not opposed thereto, and the pitches of the deep dimples 4b are different from that of the shallow dimples 4a.
Patent JP-4331812-B2 (JP)
IPC: C12N15/09
Filed: 1998-12-15
Granted: 2009-09-16
Abstract: A labeled primer (for example for the polymerase chain reaction) is described, which primer is labeled at the two ends of the oligonucleotide strand with a reporter dye molecule and a quencher molecule, and in which labeled primer at least the last base at the 3' end is not complementary to the DNA sequence to be amplified. A process for detecting a DNA sequence (by means of the polymerase chain reaction) using the labeled primer is also described, which process uses, for the amplification, one or more thermostable DNA polymerases, one of which also possesses proof-reading properties and releases the unpaired bases of the labeled primer together with the quencher molecule which is attached thereto, resulting in an increase in the fluorescence at the wavelength of the reporter dye and thereby indicating the formation of the DNA sequence which is labeled with this fluorescent dye.
Patent JP-2965690-B2 (JP)
IPC: F16L29/00
Filed: 1989-12-14
Granted: 1999-10-18
Abstract: A disconnect for coupling a postmix dispenser juice concentrate line to a bag valve of a juice concentrate bag-in-box container. The disconnect includes an open passageway therethrough with no areas or elements therein that can trap concentrate with pulp. The disconnect includes a hollow body with a juice concentrate passageway therethrough, a stationary poppet valve therein, a movable sleeve with a valve seat, and a spring biasing the sleeve into contact with the valve to close the passageway. The spring is located adjacent the outside of the sleeve to keep the spring out of the passageway.
Patent JP-2776597-B2 (JP)
IPC: C07C219/08
Filed: 1989-02-02
Granted: 1998-07-16
Abstract: Process for preparing aqueous solutions of unsaturated quaternary ammonium salts in accordance with formula H2C=C(R3)-C(O)-A-R4-N<+>(R1)(R2)(R), X<-> from at least one (meth)acrylic monomer (II) having the formula H2C=C(R3)-C(O)-A-R4-N(R1)(R2) and from at least one quaternizing agent (III) having formula RX, in the presence of at least one polymerization inhibitor. Said process is characterized in that the reaction is performed at a temperature between 10 DEG C and 80 DEG C, in that (a) in a first stage all or part of the quaternizing agent (3) required for the reaction is introduced in the reactor, said agent (2) being in a liquid state in the reaction conditions, (b) at least one (meth)acrylic monomer (II) is added, and (c) as soon as between 0 and 30 % of the stoichiometry of the (meth)acrylic monomer(s) has been introduced in the reactor, the remainder of the quaternizing agent (III) is added continuously and simultaneously, the remainder of the (meth)acrylic monomers and water until the desired concentration of unsaturated quaternary ammonium salts (I) is obtained, (d) and in the event that the quaternizing agent (III) is in the gaseous state at the reaction temperature, the reaction is effected in the presence of oxygen and a pressure is imposed so that the quaternizing agent is in the liquid state, and at the end of the reaction, the pressure is progressively reduced to atmospheric pressure, and simultaneously a ratio is established between the total gas volume flow at the output of the reactor and the volume flow of the oxygen introduced in the reactor, said ratio being less than 100.
Patent JP-H0750167-B2 (JP)
IPC: G01R27/26
Filed: 1987-03-24
Abstract: A device for detecting objects (126) behind a surface (125) comprises a row of capacitive sensor plates (116a-116i) and a corresponding row of display elements (120a-120i). As the device is moved over the surface (125) the capacitor plates (116a-116i) sense variation in the apparent dielectric constant caused by the presence of an object (126) behind the surface (125). The display elements (120a-120i) change their display accordingly and present a visual representation of the object (126) and of edges of the object (126).
Patent JP-3888692-B2 (JP)
IPC: A61Q19/10
Filed: 1996-07-11
Granted: 2007-03-07
Abstract: The present invention relates to a cleansing composition comprising at least one compound selected from N-long chain acylamino acids represented by formula (I): <CHEM> (wherein n represents 1 or 2; and R represents a saturated or unsaturated hydrocarbon group having 5 to 23 carbon atoms), and salts thereof.
Patent JP-3789934-B2 (JP)
IPC: C30B7/00
Filed: 1995-08-15
Granted: 2006-06-28
Abstract: A liquid precursor solution for use according to a method of manufacturing metal oxide electronic components (10) includes a polyoxyalkylated metal complex dispersed in an alkane solvent. The alkane solvent is preferably n-octane.
Patent JP-3643377-B2 (JP)
IPC: F16K17/16
Filed: 1995-06-13
Granted: 2005-04-27
Abstract: A multiple-domed, scored rupture disc (28) having a non-apertured disc body (62) provided with separate, side-by-side, semi-circular concavo-convex bulges (76) and an arcuate line of weakness (68) circumscribing the bulges is provided with a diametrical ridge (74) extending across and serving as a divider between the bulged areas of the disc body. The distance between the outer margin of the ridge and a plane through the annular planar section of the disc body is from about 0.3% to about 3% of the diameter of the bulged area to increase the rigidity of the divider ridge. The greater rigidity of the divider ridge decreases the burst pressure of the disc.
Patent JP-3771253-B2 (JP)
IPC: C07K14/81
Filed: 1989-09-01
Granted: 2006-04-26
Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognise the target molecule are isolated and amplified. The successful binding domains are then characterised. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M 13 phage, and the protein includes the outer surface transport signal of the M 13 gene III protein.
Patent JP-3398386-B2 (JP)
IPC: A61F2/90
Filed: 1996-08-12
Granted: 2003-04-21
Abstract: A tubular prosthesis comprises a plurality of strands integrated into an integrated structure (18, 92, 100, 114) including resilient and ductile structural strands (32, 94, 102, 112) formed of a structural material, each structural strand tending to assume a nominal shape when in a relaxed state subject to no external stress, being elastically deformable away from the nominal shape, and further being plastically deformable responsive to application of a force to the structural strand exceeding a yield stress of the structural material, being thereby adapted to acquire a curved selected nominal shape in lieu of an original nominal shape. The structural strands (32, 94, 102, 112), are plastically deformed before they are integrated into the integrated structure and thereby are altered to have respective curved selected nominal shapes, and further are selectively oriented within the integrated structure to impart to the integrated structure a tubular nominal configuration corresponding to said curved selected nominal strand shapes. <IMAGE>
Patent JP-4267694-B2 (JP)
IPC: A61L15/60
Filed: 1997-04-11
Granted: 2009-05-27
Abstract: The present invention provides a wound dressing comprising a mixture of textile fibres and gel forming fibres wherein the dressing is a knitted fabric comprising support yarn and in-laid yarn, the support yarn being substantially free of gel-forming fibres.
Patent JP-4667542-B2 (JP)
IPC: C07D477/00
Filed: 1996-12-04
Granted: 2011-04-13
Abstract: PCT No. PCT/JP96/03540 Sec. 371 Date Jul. 17, 1997 Sec. 102(e) Date Jul. 17, 1997 PCT Filed Dec. 4, 1996 PCT Pub. No. WO97/21712 PCT Pub. Date Jun. 19, 1997Disclosed are carbapenem-3-carboxylic acid ester derivatives of formula (I), wherein R1 is a hydrogen atom or a lower alkyl group, R2 is an alkyl group which may be substituted by a cycloalkyl group having about 4 to 7 carbon atoms and which may be substituted by a lower alkyl group, or is a cycloalkyl group having 4 to 7 carbon atoms which may be substituted by a lower alkyl group and n is 0 or 1. The compounds are highly absorbable through the digestive tract and are rapidly converted in the body to the active compound, which shows strong antibacterial activity.    <IMAGE>  (I)
Patent JP-3499874-B2 (JP)
IPC: A61B3/113
Filed: 1995-04-18
Granted: 2004-02-23
Abstract: A method and system are provided for sensing eye movement, such as saccadic eye movement, in a non-intrusive fashion. An optical delivery arrangement converts a laser beam pulse into a plurality of light spots. The light spots are focused such that they are incident on a corresponding plurality of positions located on a boundary whose movement is coincident with that of eye movement. The boundary can be defined by two visually adjoining surfaces having different coefficients of reflection. Energy is reflected from each of the positions located on the boundary receiving the light spots. An optical receiving arrangement detects the reflected energy from each of the positions. Changes in reflected energy at one or more of the positions is indicative of eye movement.
Patent JP-3339691-B2 (JP)
IPC: A63B69/00
Filed: 1998-02-24
Granted: 2002-10-28
Abstract: The invention describes a piece of equipment for climbing and/or balance training with adjustably arrangeable climbing grips or with an adhesion-friction coating, which consists of a flat disk on a holding system, and the disk design provides for rotating and/or tipping of the disk. By means of a guide element with rollers and/or grooves, the disk is mounted with the ability to rotate, and the rotation resistance can be varied with an adjustable brake device that is part of a mechanical brake system. In addition, with another free rotational axis, the angle of inclination of the disk can be modified, and/or by releasing the plug-in connections a combined rotating and tipping movement is made possible. Also, the rotating and tipping movements of the disk as well as the adjustments of the brake resistance can be predetermined with a programmable motor control. On the disk are openings that receive the plug-in devices for the climbing grips, the distribution of which is flexible in accordance with user preferences.
Patent JP-3926848-B2 (JP)
IPC: A01C1/08
Filed: 1997-04-10
Granted: 2007-06-06
Abstract: The invention relates to a heat treatment process for disinfection of seeds from pathogens and other undesirable fungi and bacteria, the process being characterized by supply to the seeds non water-borne heat while regulating the treatment time and temperature with regard to the condition and moisture content of the seeds in such a way that the seeds are heated from outside and in, while evaporation of moisture from the surface of the seed, and owing to that, cooling of the same is prevented and no changes in the moisture content occur.
Patent ES-2259510-B2 (ES)
Title: Aparato de descarga de aire para una aspiradora.
Inventor: LEE YONG-HEE
IPC: G11B20/10
Filed: 2004-07-01
Granted: 2007-07-16
Abstract: Aparato de descarga de aire para una aspiradora que comprende una rejilla de escape a través de la cual se escapa aire desde una cámara de motor de vacío montada en una aspiradora; una cubierta de la rejilla de escape formada en una posición correspondiente para cubrir la rejilla de escape y para cerrar la rejilla de escape cuando la aspiradora no se esté utilizando y para abrir la rejilla de escape como resultado de la fuerza generada por la contrapresión del aire de escape descargado desde la rejilla de escape cuando la aspiradora esté en uso, y un elemento elástico formado en un elemento de asiento que está situado en la proximidad de la rejilla de escape, para hacer retornar la cubierta de la rejilla de escape a la posición cerrada cuando la aspiradora deja de funcionar.
Patent ES-2544869-B2 (ES)
Title: Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa
Inventor: TERAN MOLDES MARÍA DEL CARMEN
IPC: C07D237/14
Filed: 2014-03-04
Granted: 2016-01-18
Abstract: Esta invención se refiere a derivados de piridazin-3(2H)-ona de estructura general I, II y III, que son inhibidores selectivos de la MAO-B, y a su uso para preparar medicamentos destinados a tratar trastornos derivados de la hiperactividad de la MAO-B, en particular trastornos degenerativos del sistema nervioso central (SNC), como la enfermedad de Parkinson (EP), la enfermedad de Alzheimer (EA) y otras demencias. Se trata de derivados de piridazin-3(2H)-ona que presentan fragmentos de ditiocarbamato enlazados a la posición 4, 5 ó 6 a través de una cadena alquílica de longitud variable (n = 1, 2, 3). Esta invención también se dirige a la preparación de dichos compuestos.
Patent ES-2648639-B2 (ES)
Title: Materiales luminiscentes de upconversion y método de preparación de los mismos
Inventor: PÉREZ PRIETO JULIA
IPC: C09K11/04
Filed: 2016-06-30
Granted: 2018-09-06
Abstract: Materiales luminiscentes de upconversion y método de preparación de los mismos.#La presente invención se refiere a nanopartículas de fórmula MLnF{sub,4}:RE{sup,+3}, donde M es un metal alcalino, Ln es un elemento lantánido o un análogo del mismo y RE{sup,+3} es un ión de tierras raras o combinaciones de los mismos; caracterizadas porque dichas nanopartículas comprenden ligandos orgánicos unidos a su superficie mediante enlaces covalentes. La invención además se refiere a un método de preparación de las nanopartículas luminiscentes de upconversion de la invención, al uso de las nanopartículas luminiscentes de upconversion de la invención como marcadores fluorescentes o fotosensibilizadores y a un material compuesto luminiscente que comprende las nanopartículas luminiscentes de upconversion de la invención.
Patent IE-S86346-B2 (IE)
Title: A container system for the incubation of seeds and transplantation of young plants
Inventor: O'SHEA PATRICK BRENDAN
IPC: A01G9/00
Filed: 2011-04-12
Abstract: The present invention relates to a potting container for incubation and transplanting of vegetables. The invention provides a container that is flat-pack in design comprising of two side panels with slits removed for mating with internal panels, the internal panels have slits at 40 degrees for receiving the two side panels. The assembly is secured together by inserting tie wraps in the holes at the base. The container can now be filled with soil and seeds planted. The advantage of the invention is that it allows the user to incubate the plants indoors and transplant complete rows of vegetables. Other advantages include storable in a flat-pack form. They are unobtrusive as they can be placed on a window sill.
Patent AU-2001250774-B2 (AU)
Title: Cells expressing zinc finger proteins for drug discovery
Inventor: CASE CASEY
IPC: C12N1/15
Filed: 2001-02-08
Granted: 2005-01-27
Abstract: Disclosed herein are compositions and method useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process.
Patent AU-2001284733-B2 (AU)
Title: Non-imidazole aryloxyalkylamines as H3 receptor ligands
Inventor: CARRUTHERS NICHOLAS I
IPC: C07D211/14
Filed: 2001-08-06
Granted: 2006-11-02
Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
Patent AU-2002245272-B2 (AU)
Title: Isolating cells expressing secreted proteins
Inventor: CHEN GANG
IPC: C40B30/04
Filed: 2002-01-16
Granted: 2006-06-29
Abstract: A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
Patent AU-2003218548-B2 (AU)
Title: Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers
Inventor: HEATH DOUGLAS
IPC: G16B45/00
Filed: 2003-03-20
Granted: 2008-03-06
Abstract: The invention can be summarized as follows. The present invention provides a method of displaying spectroscopic data comprising the steps of, i) obtaining spectroscopic data from a plurality of samples, each sample comprising one or more components wherein each component is characterized by an ordered pair (X,Y) of data comprising data element value X and data element value Y, wherein X is a data element value, equivalent or directly proportional to the mass of the component, and Y is a data element value equivalent or directly proportional to the amount of the component; ii) identifying all unique components comprising a common data element value X in said samples; computing the average of all X therefrom; and determining the average and optionally, the standard deviation for all Y values from all ordered data pairs comprising a common X; iii) generating a data structure comprising an array of codable cells, each cell assigned a color or other identifiable characteristic based on the relationship of the amount of each unique component present in each of said samples in relation to a predetermined value or other characteristic of the spectroscopic data. Also disclosed are data structures comprising spectroscopic data.
Patent AU-2003267614-B2 (AU)
Title: Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
Inventor: WILLIAMS SUSANNAH
IPC: C07D491/08
Filed: 2003-09-25
Granted: 2010-02-18
Abstract: Compounds of formula I: wherein Ar<SUP>1 </SUP>and Ar<SUP>2 </SUP>are optionally substituted aryl or heteroaryl, L is a bond, -CH- or -(CHR<SUP>a</SUP>)<SUB>n</SUB>-, and X is SCN, SR<SUP>1</SUP>, S(O)R<SUP>1</SUP>, (CR<SUP>a</SUP>R<SUP>b</SUP>)<SUB>m</SUB>SO<SUB>2</SUB>R<SUP>1</SUP>, SO<SUB>2</SUB>N(R<SUP>2</SUP>)<SUB>2</SUB>, SO<SUB>2</SUB>NHCOR<SUP>1</SUP>, SO<SUB>2</SUB>NHN(R<SUP>2</SUP>)<SUB>2</SUB>, OSO<SUB>2</SUB>N(R<SUP>2)</SUP><SUB>2</SUB>, OS(O)N(R<SUP>2</SUP>)<SUB>2</SUB>, OSO<SUB>2</SUB>NHCOR<SUP>1</SUP>, COR<SUP>4</SUP>, NHCOR<SUP>1</SUP>, NHCO<SUB>2</SUB>R<SUP>1</SUP>, NHCON(R<SUP>2</SUP>)<SUB>2</SUB>, NHSO<SUB>2</SUB>R<SUP>1 </SUP>or NHSO<SUB>2</SUB>N(R<SUP>2</SUP>)<SUB>2</SUB>, inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.
Patent AU-2003273141-B2 (AU)
Title: Manipulation of the rate of gastrointestinal transit by modulating intestinal methane concentration
Inventor: PIMENTEL MARK
IPC: A61K35/745
Filed: 2003-05-20
Granted: 2009-05-07
Abstract: The present invention relates to a method of diagnosing constipation in human subjects that comprises detecting the presence of methane in a breath sample from the subject. The invention also concerns agents that may be used to manipulate the rate of gastrointestinal transit and thereby treat conditions such as constipation and diarrhea.
Patent AU-2003292793-B2 (AU)
Title: Seal structure of solid feeding screw, and method of manufacturing reduced metal using the seal structure
Inventor: HASHIMOTO SUMITO
IPC: F27D99/00
Filed: 2003-12-25
Granted: 2009-07-09
Abstract: A sealing structure for a solid-transferring screw installed inside a heating furnace such as a material-leveling screw and a product-discharging screw, the sealing structure enabling the solid-transferring screw to be lifted during operation while airtightness of the heating furnace is retained. A driving shaft of the solid-transferring screw passes through through-holes formed in side walls of the heating furnace and is supported by liftable supporting devices disposed outside the furnace. Sealing blocks are attached on outer edges of the through-holes to surround the periphery of the through-holes at the outside of the furnace. Sliding panels are disposed at outer sides of the sealing blocks and have sliding holes for sliding the screw-driving shaft so that the driving shaft extends through the sliding holes. The sliding panels are brought into contact with the sealing blocks via the sealing members therebetween so that the sliding panels are slidable in the vertical direction.
Patent AU-2003298187-B2 (AU)
Title: Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2
Inventor: LO KIN-MING
IPC: C12N15/13
Filed: 2003-12-16
Granted: 2010-09-16
Abstract: The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.
Patent AU-2004218696-B2 (AU)
Title: Immunostimulatory nucleic acid molecules
Inventor: KLINMAN DENNIS
IPC: C12N15/117
Filed: 2004-10-13
Granted: 2008-11-06
Abstract: An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula:  
5'N 1 X 1 X 2 CGTTN 2 3'  
wherein the immunostimulatory oligonucleotide includes a modified backbone, at least one nucleotide separates consecutive CpGs, X 1 X 2  is GpT or ApT, N 1  is any nucleotide that includes a 5' TC or TG, N 1  + N 2  is from 0-26 bases, and the immunostimulatory oligonucleotide is from 8-30 bases in length and begins with TC or TG at the 5' end, with the proviso that neither N 1  nor N 2  contains a CCGG quadmer or more than one CCG or CGG trimer.