Patent SG-11201907442U-A (SG)
Title: METHODS FOR INCREASING BLOOD PLASMA 2'-DEOXYURIDINE (dUrd) AND THYMIDYLATE SYNTHASE INHIBITION
Inventor: Carlsson Göran
IPC: A61K45/06
Filed: 2018-02-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT onion °nolo OH 100 0010111010IIII 1111101 ow (10) International Publication Number WO 2018/150264 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61K 31/519 (2006.01) A61K 45/06 (2006.01) A61K 31/555 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01) A61K 31/513 (2006.01) (21) International Application Number: PCT/IB2018/000206 (22) International Filing Date: 09 February 2018 (09.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/458,868 14 February 2017 (14.02.2017) US (71) Applicant: ISOFOL MEDICAL AB [SE/SE]; Biotech Center, Arvid Wallgrens Backe 20, SE-413 46 Gothenburg (SE). (72) Inventors: CARLSSON, Goran, U.; Vavarevagen 33, SE-433 75 Jonsered (SE). GUSTAVSSON, Bengt; Bergs- bogatan 29, SE-426 79 Vastra Frolunda (SE). ODIN, Elis- abeth; Prastgardsangen 19, SE-412 71 Gothenburg (SE). WETTERGREN, Yvonne; Gotabergsgatan 28 B, SE-411 34 Gothenburg (SE). VEDIN, Anders; Prastgardsangen 62, SE-412 71 Gothenburg (SE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: METHODS FOR INCREASING BLOOD PLASMA 2'-DEOXYURIDINE (dUrd) AND THYMIDYLATE SYNTHASE INHIBITION FIG. 1 IWO 80 LI.V 30 6R 30 O kt) (57) : The present invention provides methods for increasing plasma dUrd levels comprising the administration of 6R-MTHF. The methods of increasing plasma dUrd increase dUrd levels compared to equimolar concentrations of LV. The present invention 0 also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF. The present invention also provides \" methods for increasing TS inhibition comprising the administration of 6R-MTHF. C [Continued on next page] WO 2018/150264 Al IMEDIMOMMIONE1013110011010HINHINVOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))