baber/WOPTO huggingface dataset:
Patent TR-200101020-T2 (TR)
Title: Aminobütirik asit türevleri
Inventor: TAKAHASHI KANJI
IPC: C07C243/34
Filed: 1998-10-07
Abstract: Genel formül (I) ile ifade edilen aminobütirik asit türevleri ve tuzlari (her simge tarifnamede tanimlandigi gibidir). Türevler matris metalloproteinazlari inhibe ederler ve dolayisiyla romatizma,osteortrit, patolojik kemik resorpsiyonu,osteoporoz, periodontal hastaliklar, interstisyel nefrit,arterioskleroz, pulmoner amfizem, hepatik siroz, kornea zedelenmesi, kanser hücrelerinin metastazina ve infiltrasyonuna veya çogalmasina bagli hastaliklar, otoimmün hastaliklar (Crohn hastaligi ve Sjögren hastaligi), beyaz kan hücrelerinin göçüne veya infiltrasyonuna bagli hastaliklar, yeni damarlanma, multipl skleroz, aort anevrizmasi, endometrit ve benzeri gibi hastaliklarin önlenmesi ve/veya tedavisinde yararlidirlar.
Patent TR-200103184-T2 (TR)
Inventor: GIBSON KEITH HOPKINSON
IPC: A61P35/00
Filed: 2000-05-03
Abstract: A compound of formula (I)or a pharmaceutically acceptable salt thereof; for use as a medicament wherein:n is 0-1;Y is selected from -NH-, -O-, -S-, or -NR<7>- where R<7 >is alkyl of 1-6 carbon atomsR<5 >is chloro or bromo;Y is selected from -NH-, -O-, -S-, or -NR<7>- where R<7 >is alkyl of 1-6 carbon atomsR<6 >is a specified cyclic group which may be substituted by various specified substituents,or R<6 >is a group -R<8>-X-R<9 >whereR<8 >is selected from various cycloalkyl, pyridinyl, pyimidinyl, or phenyl ring; any of which may be optionally subsituted as described,where X is selected from CH2, -NH-, -O-, -S-, CH2 or -NR<5>- where R<5 >is alkyl of 1-6 carbon atoms, and R<9 >is a group (CH2)mR<10 >where m is 0, or an integer of from 1-3 and R<10 >is an optionally substituted aryl or optionally substituted cycloalkyl ring of up to 10 carbon atoms,or R<10 >is a heterocyclic ring containing 1 or 2 oxygen atoms and optionally one or more substitutents; and R<1>, R<2>, R<3 >and R<4 >are each independently selected from hydrogen or various specified organic groups. Novel compounds are also described. The compounds are particularly useful in the inhibition of MEK enzymes.
Patent DE-602004002133-T2 (DE)
Inventor: ARICH KLAUS-DIETER
IPC: B23Q1/00
Filed: 2004-03-18
Granted: 2007-07-19
Abstract: An electrically powered hand held drilling and/or hammering tool having a dust collection unit powered by a motor (51) housed in the unit, which unit can be releasably fitted to the tool. A plug arrangement (12) and a cooperating socket arrangement (28), one of which is formed on the tool and the other of which is formed on the unit, are provided for electrically connecting the power supply for the tool to the motor (51) of the unit. A first mechanical fixing arrangement is provided comprising a first projection (8) and a first cooperating recess (54), one of which is formed on the tool and the other of which is formed on the unit, located adjacent the respective part of the plug and socket arrangements and a second mechanical fixing arrangement is provided, located remotely from the first and comprising a manually actuable releasable latch arrangement (72,66) and a second cooperating recess (60), one of which is formed on the tool and the other of which is formed on the unit. The first and second mechanical fixing arrangements cooperate to secure the dust collection unit to the tool in such a way that the plug and socket arrangements form an electrical connection. <IMAGE>
Patent DE-602004006976-T2 (DE)
Inventor: KOEPPL ALEXANDER
IPC: C08F2/38
Filed: 2004-04-01
Granted: 2008-02-14
Abstract: Process for preparing polyolefins having high molecular weights in the presence of a catalyst comprising an organic transition metal compound in a gas-phase fluidized-bed reactor, where the polyolefins prepared have a melt flow rate at 2.16 kg and 190° C. in accordance with ISO 1133 of less than 4 g/10 min. According to the present invention, a start-up phase during which a polyolefin having an increased melt flow rate of above 4 g/10 min is produced for a transitional period is provided. In this way, trouble-free start-up of the reactor is ensured even in the case of polymer products having a high molecular weight and a melt flow rate below 4 g/10 min and even when using catalysts based on organic transition metal compounds, in particular metallocene catalysts.
Patent DE-602004012825-T2 (DE)
Inventor: IRIKURA KOJI
IPC: B60K17/10
Filed: 2004-12-09
Granted: 2009-05-20
Abstract: The invention relates to a steerable hydraulic transaxle, comprising a motor housing (227;327) fixed to a vehicle chassis (2), wherein the motor housing (227;327) is partly formed as a kingpin (227a;327a). A hydraulic motor (210) is disposed in the motor housing (227;327) and an axle housing (228;328) is supported by the kingpin (227a;327a) to be rotatable relative to the motor housing (227;327);. Furthermore, a single axle (235;331) is disposed in the axle housing (228,328) and drivingly connected to the hydraulic motor (210), and a single wheel (236;279) is fixed onto the single axle (235;331) out of the axle housing (228;328), The invention is characterized in that the steerable hydraulic transaxle further comprises motor control means (243) for changing a displacement of the hydraulic motor in association with the rotation of the axle housing (228;328) relative to the motor housing (227;327).
Patent DE-602004013013-T2 (DE)
Inventor: NAESJE KJETIL
IPC: F16K15/14
Filed: 2004-08-13
Granted: 2009-06-25
Abstract: The present invention regards an underpressure-activated valve mechanism for controlled dispensing of fluids, including liquid food articles, from a receptacle. When the user applies sufficient suction force (P 2 ) across a pressure comparative diaphragm zone a valve opening force is applied to a valve area that has a force connection with the diaphragm zone. When the suction force ceases the valve area closes and remains closed, even in the event of overpressure (P 3 ) in the receptacle.
Patent DE-602004013146-T2 (DE)
Inventor: RENNIE PAUL JOHN
IPC: A61K33/30
Filed: 2004-06-01
Granted: 2009-07-02
Abstract: The present invention is directed to respiratory tract compositions, particularly nasal compositions, that are highly effective in the prevention and treatment of cold and influenza-like symptoms due to respiratory tract viral infections. These compositions comprise chelated and unchelated zinc ions, wherein the quantity of chelated zinc ions is at least about 50.1%.
Patent DE-602005003151-T2 (DE)
Inventor: OKA HIDEKAZU
IPC: E02F9/22
Filed: 2005-03-15
Granted: 2008-08-28
Abstract: A hydraulic control system comprising a boom control valve (7) in a first oil path (LCB) providing oil from a first hydraulic pump (2) to a boom cylinder (13), an arm control valve (10) in a second oil path (RCB) for providing oil from a second hydraulic pump (3) to an arm cylinder (16), a confluence switching valve (17) having a position (b) for joining the paths and a position (a) for stopping the confluence, a flow control valve (18) for returning pressure oil in the first oil path to a tank (28), and a control means (24,34) for switching the confluence switching valve to the confluence position and closing the flow control valve when the arm operating means (25) is operated independently and for switching the confluence switching valve to the confluence stop position and opening the flow control valve when the arm and boom operating means (25,22) are operated simultaneously.
Patent DE-602005004930-T2 (DE)
Inventor: BASS MICHAEL A
IPC: E05B19/24
Filed: 2005-09-12
Granted: 2009-02-26
Abstract: The present invention generally provides apparatus and methods for tracking, counting and inventorying keys throughout the supply chain, from manufacturing through retailing to the end user. In addition, the present invention provides apparatus and methods for improving the accuracy of duplicating keys. The apparatus and methods generally rely on Radio Frequency Identification (RFID) technology, where information is stored to and collected from RFID tags that are located proximate to keys. The apparatus and methods provided for in this invention improve efficiency and accuracy in the key supply chain.
Patent DE-602005005084-T2 (DE)
Inventor: DE CUYPER STEVEN H
IPC: G01R31/3185
Filed: 2005-10-28
Granted: 2009-03-19
Abstract: An integrated circuit (1) that comprises an internal clock circuit (12) with a clock output for clocking functional circuits (10) of the integrated circuit (1). The integrated circuit is provided with a counter circuit (16) and a state holding circuit (18) for use during testing. The integrated circuit is switched to a test mode and a start of a test time interval is signalled. Clock pulses from the internal clock circuit 12 are counted from the start of the test time interval and the state holding circuit (18) is locked into a predetermined state if the internal clock circuit has produced more than a predetermined number of clock pulses from the start of the test time interval. Information about whether the state holding circuit (18) has reached the predetermined state in the test time interval is read from the integrated circuit (1) and the information is used by a test evaluation apparatus (2) to accept or reject the integrated circuit (1).
Patent DK-1099481-T3 (DK)
Inventor: BECKER UDO
IPC: B02C18/14
Filed: 2000-11-08
Granted: 2004-01-26
Abstract: The machine comprises a cutter shaft (9) which carries several cutter blades (5) and which is held rotatably in a support frame (2). The cutter blades operate in conjunction with an additional tool in order to pulverize incoming material. The frame consists of two opposite side sections (3,4) and two end sections (5,6) which hold the shaft. Both end sections have a part which can be removed in order to remove the drive shaft.
Patent DK-1206556-T3 (DK)
Inventor: RAVN PETER
IPC: C12R1/225
Filed: 2000-08-04
Granted: 2007-05-21
Abstract: A method of identifying nucleotide sequences coding for signal peptides in lactic acid bacteria, using a DNA molecule comprising a transposon including a promoterless reporter gene from which DNA molecule a region between the LR and the reporter gene is deleted and the DNA molecule comprises a DNA sequence coding for a secretion reporter molecule. By deleting the region between the LR and the reporter gene, stop codons in-frame with the secretion reporter molecule is removed which upon transposition permits translational fusions from upstream the LR.
Patent DK-1240112-T3 (DK)
Inventor: VEHMAS JUKKA
IPC: C03B23/025
Filed: 2000-10-31
Granted: 2005-11-21
Abstract: A method of bending glass, in which glass (5) is heated in a bending furnace (1). Before the bending, the glass (5) is transferred from the heating point or zone onto a mould (7) located thereafter. While the glass (5) is being transferred onto the mould (7), the mould (7) moves in such a way that the horizontal velocity of at least the front edge of the mould (7) is substantially as high as the horizontal velocity of the glass (5).
Patent DK-1227853-T3 (DK)
Inventor: HEATON KEITH PATRICK
IPC: A61M39/10
Filed: 2000-11-08
Granted: 2008-05-26
Abstract: Apparatus is disclosed for applying negative pressure to a wound site to promote healing. The apparatus includes a porous pad for application to the wound, a suction tube linking the porous pad to a source of negative pressure, a container for collecting fluid exudate from the wound interposed between the porous pad and the source of negative pressure and a quick disconnect connector linking a first section of the suction tube leading to the porous pad with a second section leading to the container, said connector comprising two separable and non-interchangeable parts, said first section of the suction tube comprising a multi-lumen tube, one lumen being provided for applying suction to the porous pad and another being provided for monitoring pressure, said multi-lumen tube being fixedly attached at one end to the container and at the other end to one of said separable parts, said one separable part including sealing means whereby the lumens are connected in airtight manner to said second section of the suction tube.
Patent DK-1257461-T3 (DK)
Inventor: LE DROFF YVES
IPC: B63B35/32
Filed: 2000-12-28
Granted: 2003-11-24
Abstract: The invention concerns an apparatus for recuperating polluting materials, in particular hydrocarbons, capable of being installed on a seaborne or land craft, consisting of means for conveying the polluting material (6) to a storage capacity (7). The invention is characterised in that the conveying means consists of two belt conveyors, called upper belt (3) and lower belt (4), arranged one above the other so as to form a forced driving sheath (5) for the polluting material (6) to be recuperated so as to drive it to the storage capacity (7) and the upstream part of the belts (3, 4) are in direct contact with the medium containing the polluting materials.
Patent DK-1233097-T3 (DK)
Inventor: LOECHER ENGELBERT
IPC: D04H1/48
Filed: 2001-12-19
Granted: 2008-01-21
Abstract: Only fibers or filaments with a weight of 1-15dtex are included in the tuft carrier. The weight/unit area of the tuft carrier is 70-110g/m<2>, density 0.18-0.28g/m<3> and the 5% modulus value in the processing direction is  NOTLESS  60N/5cm and is preferably  NOTLESS 0.6N/g/m<2>. An Independent claim is made for a process for production of the tuft carrier from a spun fleece of thermoplastic fibers or filaments. Fibers weighing 6-15dtex are needled together and those weighing 1-5dtex are hydrodynamically treated to consolidate. Prior to drying and setting the fleece is stretched longitudinally by  NOTGREATER 30%, the relative movement of fibers being improved by addition of oil or other lubricants. Preferred Features: Preferred fiber or filament weight is 3-12dtex and 5% modulus value is 70-100N/5cm and  NOTLESS 0.7-1.0N/g/m<2>.
Patent DK-1440448-T3 (DK)
Inventor: OSTERMEYER THOMAS
IPC: G21F7/047
Filed: 2001-11-02
Granted: 2006-11-27
Abstract: Door unit has a first safety device (140) that allows the door to be opened when a flange of a container is sealingly and firmly connected with the insulator frame; and a second safety device that allows the container flange to be removed from the insulator frame only if the door is sealingly and firmly connected with the insulator frame. The first safety device has a locking unit and a locking mechanism containing a hook (117) interacting with a locking pin (116) and connected to a lever (114) and a tappet (112) inserted into the passage of a bayonet closure of the container flange and acting on the lever. Preferred Features: The lever rotates about an axis (115). The tappet and a support element pre-tensioned by a spring (120) are arranged in the region of opposing ends of the lever.
Patent DK-1187528-T3 (DK)
Inventor: VAN DER LELY ALEXANDER
IPC: A01J7/00
Filed: 2001-02-05
Granted: 2004-08-09
Abstract: The invention relates to a device (3) for taking a milk sample, which device (3) is provided with a first milk sampling device (4), the device (3) comprising switch means (6) with the aid of which cooling means (8) for cooling a sample liquid taken by the first milk sampling device (4) are activated automatically or manually.
Patent DK-1374903-T3 (DK)
Inventor: DELLA VALLE FRANCESCO
IPC: A61P31/10
Filed: 2002-06-26
Granted: 2007-07-30
Abstract: This invention refers to pharmaceutical compositions applicable for the prevention of the development and progression of mycotic skin surface diseases in human and animal, in particular of those associated with the proliferation and conversion of commensal lipophile fungi, such as for instance the genus Malassezia/Pityrosporum. More in particular, this invention refers to a composition comprising a mixture of an agonist of the receptor of type CB2 of the cannabinoids and of a fatty acid sequestering resin.
Patent DK-1549677-T3 (DK)
Inventor: HAANING JESPER MORTENSEN
IPC: A61K38/00
Filed: 2003-09-26
Granted: 2011-07-18
Abstract: The present invention relates to novel Factor VII or VIIa variants comprising a substitution in at least one position selected from the group consisting of L39, 142, S43, K62, L65, F71, E82 and F275. Such variants exhibit increased clotting activity as compared to human wild-type Factor VIIa. The present invention also relates to use of such Factor VII or VIIa variants in therapy, in particular for the treatment of a variety of coagulation-related disorders.
Patent DK-1526782-T3 (DK)
Inventor: VAN LENGERICH BERNHARD H
IPC: A23L1/00
Filed: 2003-06-17
Granted: 2010-03-01
Abstract: A stabilized emulsion is employed to produce shelf stable, controlled release, discrete, solid particles or pellets which contain an encapsulated and/or embedded component, such as a readily oxidizable component, such as omega-3 fatty acids. An oil encapsulant component which contains an active, sensitive encapsulant, dissolved and/or dispersed in an oil is admixed with an aqueous component and a film-forming component to form an emulsion. An antioxidant for prevention of oxidation of the active, sensitive encapsulant, and a film-softening component or plasticizer for the film-forming component may be included in the emulsion. The emulsion is stabilized by subjecting it to homogenization. The pellets are produced by first reducing the water content of the stabilized emulsion so that the film-forming component forms a film around the oil droplets and encapsulates the encapsulant. In embodiments of the invention, the water content of the homogenized emulsion may be reduced by spray-drying to produce a powder. In other embodiments of the invention, after homogenization, the water content of the emulsion may be reduced by admixing the emulsion with at least one matrix material to thereby encapsulate the film-coated oil droplets within the matrix material. After the water content of the emulsion is reduced, a protective coating is applied on the film-coated oil droplets to obtain pellets.
Patent DK-1470815-T3 (DK)
Inventor: SACKLER RICHARD
IPC: A61K9/54
Filed: 1994-11-22
Granted: 2006-10-02
Abstract: Oral sustained release opioid formulation comprises: an opioid analgesic, a retardant material to cause the opioid analgesic to be released at a rate to provide an analgesic effect after oral admin. to a human patient for 24 hrs, the formulation when administered in humans providing an initially rapid rate of rise in the plasma conc. of the opioid characterised by providing an absorption half-life of 1-8 hrs. in the fastened state. Method for titrating human patients with a sustained release oral opioid formulation comprises: 1) administering to a human patient on a once-a-day basis a unit dose of an oral sustained release formulation comprising a dose of an opioid analgesic and a retardant material as described above, 2) monitoring pharmacokinetic and pharmacodynamic parameters elicited by the formulation in the human patient and determining whether the pharmacokinetic and/or pharmacodynamic  parameters are appropriate to treat the patient on a repeated basis, 3) titrating t he patient by adjusting the dose of the opioid analgesic administered to the patient by administering a unit dose of the sustained release opioid analgesic formulation if it is determined that the pharmacokinetic and/or the pharmacodynamic parameters are not satisfactory or maintaining the dose of the opioid analgesic in the unit dose at a previously administered amt. if the pharmacokinetic and/or pharmacodynamic parameters are deemed appropriate, 4) continuing the step 3 titration by adjusting the dose of the opioid analgesic until appropriate steady state pharmacokinetic and/or pharmacodynamic parameters are achieved in the patient, and 5) continuing the admin. of the dose of the opioid analgesic in the oral sustained release formulation on a once-a-day basis until treatment is terminated.
Patent DK-1673625-T3 (DK)
Inventor: AEHLE WOLFGANG
IPC: C07K14/705
Filed: 2004-09-15
Granted: 2010-04-19
Abstract: The present invention provides methods and compositions for the production of stabilized proteins. In particular, the present invention provides methods and compositions for the generation of combinatorial libraries of consensus mutations and screening for improved protein variants.
Patent DK-1709167-T3 (DK)
Inventor: LIU YE
IPC: A21D8/04
Filed: 2004-12-22
Granted: 2010-08-16
Abstract: The inventors have identified amylases in fungal strains of Valsaria and found that the amylase can increase the shelf life of baked products. Particularly, the novel amylase in combination with a maltogenic amylase further improves the softness of bread crumb without having detrimental effects on elasticity.
Patent DK-1706305-T3 (DK)
Inventor: THEURER JOSEF
IPC: B66F11/04
Filed: 2004-12-07
Granted: 2008-07-07
Abstract: Disclosed is a vehicle comprising a frame (2) that is movable on tracks and a working platform (10) which is connected to telescopic columns in order to adjust the height. A swivel arm (16) which is joined to an upper end (17) of the first telescopic column (14) at one end (18) while being joined to a lower end (20) of the second telescopic column (15) at another end (19) is disposed between a first telescopic column (14) and a second telescopic column (15) that runs parallel thereto. The upper end (21) of the second telescopic column (15) is connected to the working platform (10) so as to form an articulated point (22). The swivel arm (16) can be rotated about an axis of rotation along with the second telescopic column (15) by means of a first rotary drive unit (23) while the working platform (10) can be twisted relative to the swivel arm (16) with the aid of a second rotary drive unit (26).
Patent DK-1634498-T3 (DK)
Inventor: SHYTLE DOUGLAS
IPC: C07C211/34
Filed: 1999-12-16
Granted: 2008-12-15
Abstract: A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. Medical conditions are treated by administering a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of its exo-R-mecamylamine, said amount being sufficient to ameliorate the medical condition. The medical conditions include but are not limited to substance addiction (involving nicotine, cocaine, alcohol, amphetamine, opiate, other psychostimulant and a combination thereof), aiding smoking cessation, treating weight gain associated with smoking cessation, hypertension, hypertensive crisis, Tourette's Syndrome and other tremors, cancer (such as small cell lung cancer), atherogenic profile, neuropsychiatric disorders (such as bipolar disorder, depression, an anxiety disorder, schizophrenia, a seizure disorder, Parkinson's disease and attention deficit hyperactivity disorder), chronic fatigue syndrome, Crohn's disease, autonomic dysreflexia, and spasmogenic intestinal disorders.