Patent SG-11201901899P-A (SG)
Title: Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
Inventor: SAHIN UGUR
IPC: C07K16/28
Filed: 2017-09-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111 0 1110101011111 011101 0 01111E11111110111111 011111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/054973 Al 29 March 2018 (29.03.2018) WI P0 I P C T (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, C07K 16/28 (2006.01) A61P 35/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 39/395 (2006.01) (21) International Application Number: Published: PCT/EP2017/073773 — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 20 September 2017 (20.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2016/072688 23 September 2016 (23.09.2016) EP (71) Applicants: BIONTECH AG [DE/DE]; An der Goldgrube 12, 55131 Mainz (DE). GANYMED PHARMACEUTI- CALS GMBH [DE/DE]; An der Goldgrube 12, 55131 Mainz (DE). (72) Inventors: SAHIN, Ugur; Philipp-von-Zabern-Platz 1, 55116 Mainz (DE). STADLER, Christiane; Fritz-Bock- _ ius-Str. 13, 64625 Bensheim (DE). CELIK, Leyla; = Hintere Christofsgasse 5, 55116 Mainz (DE). JEN- _ DRETZKI, Arne; Hauptstr. 163, 55246 Mainz-Kos- = theim (DE). TURECI, Ozlem; Philipp-von-Zabern-Platz 1, 55116 Mainz (DE). LE GALL, Fabrice; Gonsbachblick - 29, 55122 Mainz (DE). KREUZBERG, Maria; Obere _ Zahlbacher Str. 66, 55131 Mainz (DE). Agent: SCHNAPPAUF, Georg; ZSP Patentanwalte PartG (74) = mbB, Hansastr. 32, 80686 Munich (DE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = — SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — 1-1 M UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, IN MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 01 71' kin ........ © (54) Title: BISPECIFIC TRIVALENT ANTIBODIES BINDING TO CLAUDIN6 OR CLAUDIN18.2 AND CD3 FOR TREATMENT GO\" OF CLAUDIN EXPRESSING CANCER DISEASES 1-1 0 (57) : The present disclosure provides binding agents comprising at least three binding domains, wherein a first binding domain \" binds to a T cell-specific antigen and a second binding domain and a third binding domain bind to a claudin, and methods of using these 0 binding agents or nucleic acids encoding therefor for treating cancer.