baber/WOPTO huggingface dataset:
Patent CA-2304494-A1 (CA)
Title: A novel heteromultimeric ion channel receptor and uses thereof
Inventor: SEGUELA PHILIPPE
IPC: A61K48/00
Filed: 2000-04-20
Abstract: The present invention describes a novel heteromultimeric proton-gated ion channel (herein called ASIC-2S.2) with distinctive properties. Compositions and methods are provided for producing and expressing functional ASIC-2S.2 channels, composed of ASIC2A and ASIC3 subunits. The invention also provides genetically engineered expression vectors comprising the nucleic acid sequences encoding both ASIC2A and ASIC3 and host cells coexpressing both ASIC2A and ASIC3 subunits. Also provided herein are genetically engineered nucleic acids encoding chimeric proton-gated ion channels comprised of at least two different subunits, as well as expression vectors and host cells comprising said engineered nucleic acids. The invention also provides for the use of ASIC-2S.2, as well as agonists, antagonists or antibodies specifically binding ASIC-2S.2, in the diagnosis, prevention and treatment of diseases associated with expression of ASIC-2S.2. Also are disclosed methods of influencing electrophysiological, pharmacologi-cal and/or functional properties of ASIC-2S.2 as well as methods for screening for substances having ion-channel modulating activity or substances capable of disrupting subunit association or interaction..
Patent CA-2305579-A1 (CA)
Title: Methods and apparatus for blind riveting
Inventor: DENHAM KEITH
IPC: B21J15/06
Filed: 1998-10-05
Abstract: Methods and apparatus of blind riveting. By forming a near-side head during the riveting process, the rivet is able to accommodate a larger gap between workpiece which may be closed up without reducing clamp force and therefore joint strength.
Patent CA-2307782-A1 (CA)
Title: Diffusion-type ndir gas analyzer with convection flow
Inventor: KOUZNETSOV ANDRIAN
IPC: G01N21/35
Filed: 1998-10-21
Abstract: A diffusion-type NDIR gas analyzer (100) with an improved response time due to convection flow created by a temperature gradient between gas located within a waveguide (2) and gas located within a diffusion pocket of space (8) created between the waveguide and a semi-permeable membrane (7) which surrounds the waveguide. The temperature gradient may be created by a thermally resistive radiation source (1) that is not thermally isolated from the waveguide. The semi-permeable membrane is made of a hydrophobic material and has a thickness sufficient to provide its own structural integrity. The semi-permeable membrane can have a pore size less than approximately 50 micrometers and be comprised of ultrahigh molecular weight polyethylene or other suitable materials.
Patent CA-2308036-A1 (CA)
Title: Analogues of lipopolysaccharide-binding protein (lbp)-derived peptides that efficiently neutralize lipopolysaccharides (lps)
Inventor: GLAY CHINEA SANTIAGO
IPC: C07K14/47
Filed: 2000-06-06
Abstract: The invention provides an LPS-binding and -neutralizing peptide comprising the amino acid sequence X-1-2-3-4-5-6-7-8-9-10-11-12-13-14-Y, wherein:      X is a linear chain from zero to four amino acids. (1) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +5, +9, +10, +11 or +13 has been replaced (from the native LBP sequence) according to what is herein described, then (1) could also be arginine or lysine.   (2) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine.   (3) is one of the amino acids glutamine, asparagine, serine or threonine.   (4) is one of the amino acids glycine, alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine. (5) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, t9, t10, +11 or +13 has been replaced according to what is herein described, then (5) could also be arginine or lysine. (6) is one of the amino acids tryptophan or phenylalanine. (7) is one of the amino acids lysine or arginine. (8) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine or tyrosine. (9) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, +5, +10, +11 or +13 has been replaced according to what is herein described, then (9) could also be arginine or lysine. (10) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine; and if and only if at least one of the a.a. at positions +1, +5, +g, +11 6 +13 has been replaced according to what is herein described, then (10) could also be lysine or arginine. (11) is one of the amino acids alanine or valine; and if and only if at least one of the a.a. at positions +1, +5, +g, +10, o +13 has been replaced according to what is herein described, then (11) could also be serine; and if and only if the a.a. at position +10 has bean replaced according to what is herein described, then (11) could also be threonine, glutamine, asparagine, lysine or arginine. (12) is one of the amino acids phenylalanine, tryptophan or tyrosine. (13) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, +5, +9, +10 o +11 has been replaced according to what is herein described, then (13) could also be phenylalanine, arginine or lysine; and if and only if the a.a at position +14 is lysine or arginine, then (13) could also be glycine. (14) is one of the amino acids lysine, arginine or alanine, and if and only if the a.a. at position t13 has been replaced according to what is herein described, then (14) could also be valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine.
Patent CA-2309653-A1 (CA)
Inventor: FRICK INGA-MARIA
IPC: A61K38/00
Filed: 1998-11-11
Abstract: The use of protein H, and fragments or derivatives thereof, as cytostatic agents, especially in the treatment of diseases involving undesired cell proliferation.
Patent CA-2311643-A1 (CA)
Inventor: GREGORY RICHARD J
IPC: C12Q1/02
Filed: 1998-12-04
Abstract: The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA  binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivor proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
Patent CA-2314118-A1 (CA)
Title: Agent de type toner
Inventor: KUBOTSU MASAMITSU
IPC: C07C65/11
Filed: 1999-10-14
Abstract: La présente invention concerne un agent de type toner pour pigments azoïques, un pigment azoïque teinté, et leur procédé de production. En outre, on ajoute un acide 2-hydroxynaphtalène-3,6-dicarboxylique et un dérivé de celui-ci à un principal ingrédient de couplage d'un pigment azoïque. Le mélange obtenu est couplé à un sel de diazonium aromatique.
Patent CA-2314561-A1 (CA)
Title: A bolt and a manufacturing method thereof
Inventor: KATO TAKASHI
IPC: F16B35/04
Filed: 2000-07-20
Abstract: The object of the present invention is to prevent the encroaching and the seizure between the bolt and the female screw caused by an oblique screwing of the bolt into the female screw when the bolt and the female screw are fastened together. Another object of the present invention is to manufacture the bolt in a low cost, by using said bolt, the encroaching and the seizure between the bolt and the female screw caused by a oblique screwing of the bolt into the female screw are certainly prevented. Said objects may be attained by a bolt consisting of a column part and a polygonal pillar part extending from an end of said column part wherein a complete thread is formed on said column part and a screw blade continuing to said complete thread is formed on said polygonal pillar part.
Patent CA-2318275-A1 (CA)
Title: Method and apparatus for control of reeling
Inventor: RAUTAKORPI TIMO
IPC: B65H18/20
Filed: 1999-01-22
Abstract: In the method for controlling reeling in a reel-up of a paper web, a paper web (W) is guided via a rotating reeling cylinder (1) around a reel spoll (2) into a reel (R) in such a way that the paper web (W) is passed onto the reel via a nip (N) between the reeling cylinder (1) and the reel (R). The paper web (W) running onto the reel is subjected to a load by means of actuators of the reel-up, which load affects the structure of the reel and is controlled by means of measured variables determined during the reeling process. A reel density is used as the measured variable, the reel density being determined during the reeling process continuously or at intervals, wherein it is possible to implement a closed control loop.
Patent CA-2318740-A1 (CA)
Title: Pai-2 and t-pa as diagnostic markers of periodontal disease
Inventor: XIAO YIN
IPC: G01N33/53
Filed: 1999-01-26
Abstract: The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and they also correlate with the severity of disease at different sites in the same patient.
Patent CA-2322948-A1 (CA)
Inventor: WARDLAW STEPHEN C
IPC: G01N33/49
Filed: 1999-02-17
Abstract: Formed constituents of a quiescent anticoagulated whole blood sample are optically analyzed by an optical scanning instrument (54), which sample is contained in a sample chamber (14) that has a varying through plane thickness. The thickness of any fields of view in the blood sample which contain plasma lacunae can be calculated by the instrument as a function of signal emission strength emanating from the colored plasma in the lacunae. The signal emissions can be the result of sample fluorescence or can be the result of signal density emanating from the sample. Particle volumes can be measured as a function of signal emission suppression which is caused by formed particles in the blood sample. The scanning instrument is calibrated by means of the inclusion of a calibration area (13, 38, 40) associated with the chamber which calibration area includes a portion (37) which receives a known depth of colored plasma from the blood sample, and which calibration area also includes a colorant-emission-altering feature (36) which feature has a known volume. The scanning instrument scans the known depth portion of the calibration area to determine what degree of signal emission strength correlates to the known depth, and the scanning instrument also scans the colorant-emission-suppressing feature to determine what degree of signal alteration correlates to the known volume of the aforesaid feature. The instrument stores the information gained from the calibration area and then proceeds to analyze the blood sample for formed constituent volumes and constituent counts per unit of the blood sample.
Patent CA-2323416-A1 (CA)
Inventor: KAKIUCHI TOSHIHITO
IPC: C09K23/00
Filed: 1999-03-11
Abstract: L'invention concerne des acides polyènepolycarboxyliques représentés par la formule (1), dans laquelle n représente un entier de 0 à 5 et m représente un entier 1 ou 2, à condition que m représente 1 quand n représente 0. Les composés selon l'invention, leurs dérivés concernant les groupes carboxyliques, et leurs sels sont des composés dérivés d'une substance naturelle qui peuvent présenter une excellente capacité de dispersion quels que soient les types de substances à disperser.
Patent CA-2330910-A1 (CA)
Title: A waterproof high voltage connector
Inventor: RUMSEY ROGER L
IPC: H01R24/38
Filed: 2001-01-11
Abstract: For use with a flexible cable having a central current carrying electrical conductor, a symmetrical layer of insulation concentrically surrounding the central conductor, a symmetrical circumferential layer of shielding conductor surrounding the layer of insulation, and a symmetrical outer sheath of insulation surrounding the shielding conductor, a wiring system formed of a fitting of conductive material having a passageway therethrough that receives the flexible cable, a short length shield connector of bare conductive metal having a first portion inserted through an opening in the flexible cable outer sheath of insulation to conductively engage the cable circumferential layer of shielding conductor and having a second portion that remains exterior of the flexible cable outer sheath of insulation; and a short length electrically conductive tubular ground ring slidably received on the cable and overlying a portion of the shield connector, the ground ring being crimpable whereby when crimped it securely engages the exterior of the cable and the shield connector, the fitting being slidably positioned over the ground ring, continuity thereby being provided from the cable shielding conductor through the shield connector and the ground ring to the fitting.
Patent CA-2332873-A1 (CA)
Inventor: CORNISH ANDREW
IPC: G02B6/12
Filed: 1999-06-03
Abstract: Un circuit de transmission optique accordable comprend une source (20) de lumière formant l'entrée d'un guide d'onde (12), un détecteur (21) détectant la lumière sortant du guide d'onde, un comparateur destiné à comparer la sortie avec une valeur prédéterminée afin de produire un signal de différence et un modulateur de guide d'onde destiné à changer la transmission du guide d'onde en fonction du signal de différence jusqu'à ce que la sortie corresponde à la valeur prédéterminée. Dans un mode de réalisation préféré, la modulation du guide d'onde est effectuée à l'aide d'un laser de réglage (30) utilisé pour former une encoche (31, 32) dans la paroi du guide d'onde optique.
Patent CA-2333107-A1 (CA)
Inventor: POLINIAK EUGENE SAMUEL
IPC: A61K9/70
Filed: 1999-06-08
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by  more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit an d is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
Patent CA-2333728-A1 (CA)
Inventor: DIFFRIENT NIELS
IPC: E04B2/74
Filed: 1999-06-04
Abstract: A space dividing system (50) includes a column (56) and a series of partition panels (58) adapted for interconnection with the column. The column includes an internal passage, and is adapted to receive wiring from a building for supplying power to a receptacle arrangement (162) interconnected with the column. Adjacent panels (58) are connected to the column (56) at spaced locations, and the receptacle arrangement (162) is exposed between the adjacent panels. The column includes a structural skeleton to which the receptacle arrangement is mounted, and a series of covers (152) are releasably engaged with the structural skeleton for finishing the aesthetic appearance of the column. An adjustable height mounting arrangement is interconnected with the upper end of the column for connection to a ceiling to stabilize the upper end of the column. Each panel is in the form of a frame defining an opening within which a core is received.
Patent CA-2334102-A1 (CA)
Inventor: VOLSTAD OVE CHARLES
IPC: F24D5/10
Filed: 1999-05-20
Abstract: The invention relates to a device by a constructional part (1) preferably extending between supporting parts (10, 11, 12) of a building or plant construction, and preferably forming a partition between storeys, such as a floor or deck. The constructional part (1) is self-supported, preferably of light-weight material and comprises a channel system for air, so that the constructional part (1) may provide heating and/or cooling of rooms in the building or plant construction, or may thaw snow and ice lying on the construciontal part, respectively. The constructional part (1) is made up of at least three interconnected layers (2, 3, 4) of corrugated sheet material. The layers (2, 3, 4) are arranged at angles in relation to each other, in such a way that corrugations form a preferably right angle between themselves, so that the corrugations of the layers (2, 3, 4) form a channel system in the constructional part (1). A number of holes (6) are made in the intermediate layer (3). The holes (6) extend transversely to and preferably in a plane through the mid section of the corrugations, so that air at a temperature suitable for heating and/or cooling, or thawing, respectively, may be supplied and/or extracted in a controlled manner in the channel system formed. The corrugations of the upper layer (4) are advantageously filled with an additional cast (5) of light-weight material of good thermal conductivity to a level at least at the height of the corrugation ridges of the upper sheet layer (4).
Patent CA-2334470-A1 (CA)
Title: Method and system for moving equipment into and through a conduit
Inventor: BIJLEVELD AARNOUD FREDERIC
IPC: E21B4/18
Filed: 1999-06-11
Abstract: A method and system are disclosed for moving equipment into and through a conduit that is preferably an oil and/or gas production well, wherein use is made of an uphole equipment storage and handling unit via which equipment modules can be moved into a launch conduit and connected to a shuttle device which is able to locomote itself as a wireless tractor via the launch conduit into and from the underlying conduit.
Patent CA-2336955-A1 (CA)
Title: Method and device for producing illusory magnetic stimulation
Inventor: RUOHONEN JARMO
IPC: A61N2/00
Filed: 1999-07-01
Abstract: Disclosed is a method for producing a magnetic stimulation effect and/or a fake magnetic stimulation effect in a biological tissue.  According to the method, the real magnetic stimulation is effected by virtue of inducing an electromagnetic field in said biological tissue with a sufficiently strong field strength to essentially excite said tissue, and the fake magnetic stimulation is effected by virtue of inducing an electromagnetic field in said biological tissue with a field strength that is weaker than the electromagnetic field required for an essential excitation of said tissue. According to the invention, said electromagnetic field weaker than the electromagnetic field strength required for an essential excitation of the tissue is produced by the steps of inducing at least one first electromagnetic field in said biological tissue, and simultaneously, inducing at least one second electromagnetic field superimposed with said first electromagnetic field but so deviated by its direction from the direction of said first electromagnetic that the sum effect of said electromagnetic fields in the target area of said biological tissue remains weaker than the electromagnetic field required for an essential excitation of said tissue. Also an apparatus is described suited for implementing the method.
Patent CA-2339974-A1 (CA)
Title: Method and apparatus for continuously steaming and boiling rice
Inventor: MIYAGAWA TOMOYUKI
IPC: A23L7/196
Filed: 1999-08-06
Abstract: A method for continuously steaming rice includes the steps of evenly placing rice on a moving carrying surface of a single conveyor belt after the rice absorbed water, primarily steaming the rice by blowing steam to the rice placed on the carrying surface, sprinkling of hot water to be absorbed into the rice, and secondarily steaming the rice by blowing steam into the rice. These steps are performed successively without agitating the rice on the single conveyor belt within a sealed housing. The apparatus has a housing made up of a lower housing member and an upper housing member capable of moving vertically relative to the lower housing member. The boundary between the upper and lower housing members is sealed by drained water during a steaming step.
Patent CA-2341679-A1 (CA)
Inventor: PETROPOULOS CHRISTOS J
IPC: C12Q1/68
Filed: 1999-06-24
Abstract: This invention relates to antiviral drug susceptibility and resistance tests  to be used in identifying effective drug regimens for the treatment of human  immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrom e (AIDS) and further relates to the means and methods of monitoring the clinic al progression of HIV infection and its response to antiretroviral therapy, particularly nucleoside reverse transcriptase inhibitor therapy using phenotypic susceptibility assays or genotypic assays.
Patent CA-2343854-A1 (CA)
Inventor: BERGERSEN EARL O
IPC: A61C7/08
Filed: 2001-04-11
Abstract: An orthodontic appliance is provided which includes an upper tooth receiving trough and a lower tooth receiving trough which are hinged together at a posterior portion of the appliance. The hinge is constructed so that the appliance is self opening to cause the troughs to maintain contact with the teeth when the patient's mouth is open. The appliance is formed of a soft and sticky plastic material so that it will adhere closely to the patient's teeth. Surface features are provided on opposing surfaces of the troughs to prevent the troughs from sticking to one another when the appliance is closed. An interference area is provided at the hinges to prevent the hinges from completely closing to assist in self opening of the appliance.
Patent CA-2345035-A1 (CA)
Title: System and method for attaching soft tissue to bone
Inventor: NOVAK VINCENT P
IPC: A61B17/56
Filed: 2000-07-20
Abstract: A system and method for attaching soft tissue to bone.
Patent CA-2349614-A1 (CA)
Title: Method and device for receiving at least two reception paths, and corresponding use
Inventor: LAUNAY ERWAN
IPC: H04B7/08
Filed: 1999-11-15
Abstract: The invention relates to a reception device implementing at least two reception paths supplied with data flows, each conveying the same source symbols, each of said paths comprising estimation means, associating, with each source symbol received, an estimated path value and a corresponding path confidence information element, and comprising means for the combination of said estimated path values into an adapted estimated value, said combination taking account of said path confidence information elements to weight said estimated path values. Said estimation means advantageously comprises means for the estimation of the transmission channel, delivering said path confidence information elements. Said combination means may advantageously associate an adapted confidence information element with each of said adapted estimated values, as a function of said path confidence information elements.