baber/WOPTO huggingface dataset:
Patent CA-2222823-A1 (CA)
Inventor: MOTTO DAVID G
IPC: C12N15/12
Filed: 1997-12-22
Abstract: COMPOSITIONS OF SLAP-130, A SLP-76 ASSOCIATED PROTEIN, AND METHODS OF USE THEREFOR     Isolated nucleic acid molecules encoding a novel phosphoprotein, SLAP-130, that interacts with the SH2 domain of the leukocyte protein SLP-76, are disclosed. In addition to isolated nucleic acids molecules encoding SLAP-130, the invention provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a SLAP-130 transgene. The invention further provides isolated SLAP-130 proteins and peptides, SLAP-130 fusion proteins and anti-SLAP-130 antibodies. Methods of using the SLAP-130 compositions ofthe invention are also disclosed, including methods for detecting SLAP-130 protein or mRNA in a biological sample, methods of modulating SLAP-130 activity in a cell, and methods for identifying agents that modulate an interaction between SLAP-130 and SLP-76.
Patent CA-2223349-A1 (CA)
Title: Use of lower alkanoyl l-carnitines to produce a medicament suitable for the therapeutic treatment of retinopathies
Inventor: CAVAZZA CLAUDIO
IPC: A61P27/02
Filed: 1997-12-03
Abstract: Use of lower alkanoyl L-carnitines to produce a medicament suitable for the therapeutic treatment of retinopathies.     The use of lower alkanoyl L-carnitines (e.g. acetyl L-carnitine) and the pharmacologically acceptable salts thereof to produce a medicament suitable for the therapeutic treatment of retinopathies, e.g. the age-related maculopathy (ARM) and non-age-related maculopathy (nARM), is disclosed.
Patent CA-2225979-A1 (CA)
Title: Illuminated knob assembly
Inventor: PIZZO WILLIAM C
IPC: H01H9/16
Filed: 1997-12-30
Abstract: The control knob includes a chamber into which a translucent polycarbonate jewel light pipe assembly of a first color, such as blue,  and a translucent polycarbonate jewel cap of a second color, such as white, are inserted.  The jewel cap is engaged against said jewel light pipe assembly and includes a bulbous portion which protrudes or stands proud through an axially oriented slot in the sidewalls of the control  knob thereby forming  an  indicator  for  the  control  knob.    In  ambient illumination, such as during the day, the indicator appears to be the color of the jewel cap, such as white.  However, when the dashboard is electrically illuminated, such as during the night, the illumination is collected by the jewel light pipe, and the color of the jewel light pipe assembly, such as blue or blue-green, is projected through the cap assembly and the indicator appears to be blue or blue green.
Patent CA-2229448-A1 (CA)
Inventor: MILAN HENRY
IPC: H01R24/62
Filed: 1996-08-13
Abstract: A modular surge protection system (20) is provided having interchangeable power supply (24) and surge protection (23, 25) modules connectable to a power distribution module. The power distribution module provides surge protection for the power supply modules while independent surge protection is provided in the surge protection modules.
Patent CA-2230681-A1 (CA)
Title: Power-up/power-down detection circuit
Inventor: KIM HONG SEOK
IPC: H03K17/22
Filed: 1998-02-27
Abstract: A power-up detector for detecting power-up and power supply voltage bump conditions comprising a current mirror connected to a power supply, a pair of series connected resistors connected between the current mirror and ground, and providing a bias point at a junction of the series connected resistors, and a field effect transistor having a source-drain circuit connected between the current mirror and ground for providing an output signal, the transistor being controlled by the bias point.
Patent CA-2231646-A1 (CA)
Title: An encapsulated crystalline calcium carbonate builder for use in detergent compositions
Inventor: PANCHERI EUGENE JOSEPH
IPC: C11D3/02
Filed: 1998-03-10
Abstract: A detergent composition containing an inexpensive detergent builder in the form of a selected crystalline calcium carbonate that has been coated with an encapsulating material such as a carbohydrate is provided. The crystalline calcium carbonate can be calcite and the encapsulating material can be sucrose. The crystalline calcium carbonate of the present invention is extremely inexpensive because it performs well even when used at large median particle sizes (e.g. less than 10 m2/g surface areas).
Patent CA-2232214-A1 (CA)
Inventor: BECKWITH ELAINE
IPC: B22C1/00
Filed: 1998-03-16
Abstract: A method of making sand cores to obtain optimum mechanical properties and particularly to obtain accurate adjustment of the gas curing cycle for making optimum resin-coated sand cores.  The method comprises blowing, into a core box cavity, mixture of core making particulated sand and gas curable liquid resin having a first level of pH, such mixture containing a uniform distribution of a pH indicating dye additive that changes color in response to a change in pH level, in contact therewith, such blowing being continued to fill the cavity to a desired density and form an uncured sand core shape with a predetermined porosity,  (b) introducing a catalyst gas having a second level of pH, through the pores of the core shape to cure the resin and contact the dye additive,  (c) concurrently, or subsequent to step (b), sensing the degree of color change of any part of the core shape that is or has taken place as a result of exposure to the flow front of the catalyst gas, and (d) responding to such color sensing to modify the parameters of catalyst gas introduction (i.e. exposure time, gas pressure, gas concentration or gas inlet/out location) to ensure the desired degree of catalyst reaction in the desired time period.
Patent CA-2232374-A1 (CA)
Title: Phenylacetic acid derivatives, processes and intermediates for their preparation, and compositions comprising them
Inventor: MUELLER RUTH
IPC: C07C251/62
Filed: 1996-10-11
Abstract: Disclosed are phenylacetic acid derivatives of formula (I) in which the substituents and the index have the following meanings: X is NOCH3, CHOCH3, CHCH3; Y is O or NR; R1, R independently of one another stand for hydrogen or C1-C4 alkyl; R2 stands for cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy; m is 0, 1 or 2 and the R2 groups can be different if m is 2; R3 is hydrogen, cyano, C1-C4 alkyl, C1-C4 alkyl halide, C3-C6 cycloalkyl; R4, R5 and R6 have the meanings indicated in claim 1. Also disclosed are the salts of the claimed derivatives, a process and intermediate products for producing them and agents containing them for use in pest and fungus control.
Patent CA-2236744-A1 (CA)
Inventor: SANSONE RONALD P
IPC: G07B17/00
Filed: 1998-05-05
Abstract: A inexpensive and time saving method and system for reducing the use of gummed service stickers and the completion by hand of special forms for specialty mail is disclosed. This invention also reduces the amount of trips that have to be made to the post. The foregoing may be accomplished by replacing the standard (fixed) graphic cartridge that is normally supplied with a standard digital postage meter with an addressable "ram" image cartridge.          The addressable ram image cartridge may also be linked to a personal computer, where a program would allow the user to request specialty mail services. Once the desired service (services) are selected, the required postal graphic images are downloaded into the ram cartridge. Next, postal payment, if any, is totaled and the additional postal value is totaled and passed to the postal meter vault for totaling and printing in an accountable way. Finally, the personal computer meter or postage meter cycles normally first printing the indicia and then the graphics and bar codes as specified by each postal service that was selected by the user.
Patent CA-2239113-A1 (CA)
Inventor: SPRIGGS HARRY JOHN
IPC: A63H37/00
Filed: 1998-07-30
Abstract: A device (26) for propelling novelty items (28) comprising a structure (30) for holding the novelty items (28).  A component (32) is for supporting the holding structure (30) in an upright position.  A facility (34) in the supporting component (32) is for ejecting the novelty items (28) out of an open top end (36) of the holding structure (30) when activated.
Patent CA-2242802-A1 (CA)
Title: Mounting structure for one or more semiconductor devices
Inventor: IKEDA HIRONOBU
IPC: H05K3/36
Filed: 1998-07-09
Abstract: A mounting structure wherein, in a semiconductor package mounting position on a wiring board, a package bearing substrate whose external size is substantially equal to or larger than that of the semiconductor package and which has on its upper surface pads for connection to a semiconductor package and on its lower surface pads for connection to the wiring board is arranged, the pads on the wiring board and those on the lower surface of the package bearing substrate are connected by soldering, and the soldered junction is filled and fixed with an under-fill.
Patent CA-2242908-A1 (CA)
Title: Recepteur hsatu68 de la chemokine de la proteine g humaine
Inventor: LI YI
IPC: C12P21/00
Filed: 1996-01-11
Abstract: L'invention concerne des polypeptides faisant fonction de récepteurs de la chemokine de la protéine G humaine et l'ADN (ARN) codant ces polypeptides, ainsi qu'un procédé pour produire ces polypeptides par des techniques de recombinaison. L'invention concerne également des méthodes d'utilisation de ces polypeptides afin d'identifier des antagonistes et des agonistes de ces polypeptides, ainsi que des méthodes d'utilisation thérapeutique de ces agonistes et antagonistes pour traiter des états liés respectivement à la sous-expression et à la surexpression de ces polypeptides faisant fonction de récepteurs de la chemokine de la protéine G. L'invention concerne en outre des méthodes diagnostiques pour détecter une mutation dans les séquences d'acides nucléiques des récepteurs de la chemokine de la protéine G et pour détecter un taux de la forme soluble des récepteurs dans un échantillon prélevé sur un hôte.
Patent CA-2245941-A1 (CA)
Title: Disposable test strips for determination of blood analytes, and methods and compositions for making same
Inventor: ALVAREZ-ICAZA MANUEL
IPC: C12Q1/00
Filed: 1997-02-11
Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a working formulation containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The working formulation is printed over a conductive carbon base layer to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive base layer.  The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.
Patent CA-2246541-A1 (CA)
Title: Intermediate for use in docetaxel synthesis and production method therefor
Inventor: SISTI NICHOLAS J
IPC: C07D305/14
Filed: 1997-02-27
Abstract: C7, C10 di-CBZ 10-deacetyl Baccatin III of formula (1) provides an intermediate for the production of docetaxel.      A method of producing this C7, C10 di-CBZ 10-deacetyl Baccatin III is provided. Here, 10-deacetyl Baccatin III is acylated with at least 1.5 equivalents of n-butyl lithium and at least 1.5 equivalents of benzyl chloroformate in tetrahydrofuran. The 10-deacetyl Baccatin III may first be dissolved in tetrahydrofuran after which the n-butyl lithium is added followed by the addition of the benzyl chloroformate.      The reaction is preferably at a reduced temperature of less than - 20 °C. The resulting solution may be quenched with ammonium chloride and reduced to residue. The residue may then be redissolved in an organic solvent, washed, dried and recrystallized to purify the compound.
Patent CA-2249992-A1 (CA)
Title: Process for the carbonylation of acetylenically unsaturated compounds
Inventor: JAGER WILLEM WABE
IPC: C07C69/54
Filed: 1997-03-25
Abstract: The invention relates to a process for the carbonylation of acetylenically unsaturated compounds, whereby a feedstock comprising an acetylenically unsaturated compound and a relatively minor amount of a 1,2-alkadiene compound is contacted under carbonylation conditions with carbon monoxide and a co-reactant, in the presence of a catalyst system, based on: a) a source of cations of one or more metals of Group VIII of the Periodic Table; b) a phosphine having an aromatic substituent which contains an imino nitrogen atom separated by at least one bridging carbon atom from the phosphorus atom; and c) a protic acid, characterized in that the catalyst system is further based on d) a monodentate monophosphine or monophosphite.
Patent CA-2250651-A1 (CA)
Title: High pressure cryogenic fluid delivery system
Inventor: PRESTON AUDREY DUANE
IPC: F17C9/02
Filed: 1998-10-20
Abstract: A system delivers cryogenic gas at a high pressure from a supply of cryogenic li quid maintained at a low pressure in a bulk tank. The bulk tank supplies liquid to at least one transfer tank. The transfer tank is pressurized by connecting it to a pressure building t ank containing gas at a high pressure. A heat exchanger is connected in circuit between the transfe r tank and the pressure building tank. The transfer tank provides liquid at a high pressure to the heat exchanger so that a vapor is produced. This vapor is fed to the pressure building tank so that the high pressure therein is maintained. The transfer tank provides a high pressure flow of liquid to a vaporizer and a high pressure gas storage tank so that high pressure cryogenic g as may be produced and stored.
Patent CA-2251429-A1 (CA)
Title: Acid-resistant, thermoplastic resin composition containing magnesium hydroxide and its use
Inventor: HIRAISHI WATARU
IPC: C09C1/02
Filed: 1998-10-16
Abstract: An acid-resistant, thermoplastic resin composition which is nonpoisonous and non-halogen and has an acid- resistance for a long period of time, the acid-resistant, thermoplastic resin composition containing a thermoplastic resin, 30 to 70 % by weight of magnesium hydroxide which has a specific surface area of 20 m2/g or less and an average secondary particle diameter of 0.2 to 5.0 µm and is surface-treated with at least one surface-treating agent selected from a water-soluble silane-coupling agent, a phosphoric acid ester, a higher fatty acid or its alkali metal salt, and 1 to 20 % by weight of a reaction type compatibilizing agent.
Patent CA-2254911-A1 (CA)
Title: Graphitic nanofibers in electrochemical capacitors
Inventor: NIU CHUN-MING
IPC: H01M4/58
Filed: 1997-05-15
Abstract: Graphitic nanofibers, which include tubular fullerenes (commonly called "buckytubes"), nanotubes and fibrils, which are fucntionalized by chemical substitution, are used as electrodes in electrochemical capacitors. The graphitic nanofiber based electrode increases the performance of the electrochemical capacitors.
Patent CA-2257582-A1 (CA)
Inventor: PROCOPIO FRANK
IPC: A61K6/838
Filed: 1997-06-06
Abstract: La présente invention concerne un procédé permettant de déposer un matériau sur une surface, telle qu'une dent ou un os, dans le but de réparer ou de restaurer ladite surface. On distribue le matériau sous forme de poudre et on le fait fondre par application laser. Le matériau en fusion est entraîné dans un jet de fluide à grande vitesse, généralement un gaz tel que l'air, et dirigé vers la surface à traiter, sur laquelle ledit matériau en fusion se solidifie. Les matériaux de la présente invention comprennent l'hydroxyapatite, l'alumine et le dioxyde de silicium.
Patent CA-2258755-A1 (CA)
Inventor: ZHAO JING
IPC: C12N15/09
Filed: 1997-06-20
Abstract: La thérapie génique peut traiter l'obésité chez les mammifères. On administre un gène de régulation de l'obésité à un mammifère. De préférence, le gène code la leptine ou un récepteur de la leptine. La protéine qui est administrée et exprimée in vivo est plus efficace que la protéine qui est injectée dans l'animal.
Patent CA-2260139-A1 (CA)
Title: Method and apparatus for inter-system handoff within a plural hyperband supporting cellular telephone network
Inventor: OLVERA-HERNANDEZ ULISES
IPC: H04W36/14
Filed: 1997-07-08
Abstract: A cellular telephone network (10) includes plural system areas (32) each having a plurality of cells (12). The system areas do not support cellular communications in all of the same hyperbands. When a verification signal strength measurement (118, 218) is needed, a message (114, 116) is sent from a first one of the system areas to a second one of the system areas, with the message including not only an identification for measurement of the traffic channel currently being used by a mobile station, but also an identification of the hyperband within which that traffic channel exists. The report (120, 122) on the results of the requested measurement and hyperband capabilities of target cell is then sent from the second system area to the first system area.  From this information, the first system area may confirm (124, 224) that the measurement was made or was attempted in the proper hyperband and thus determine whether the second system would be able to support mobile station operation with respect to hyperband in the event of an inter-system hand off.
Patent CA-2260702-A1 (CA)
Inventor: STEDING FRANK
IPC: C07F7/04
Filed: 1999-02-04
Abstract: Disclosed is a continuous process for producing a chlorine-free tetraalkoxysilane of the formula (R1O)4Si (wherein R1 is hydrocarbon) from metallic silicon powder and an alcohol (R1OH) in the presence of the a base catalyst with improved selectivity and improved yields. The catalyst is a mixture of a silicon compound [R2O-(R3O)m]n Si[OR1]4-n, an alkali metal alcoholate R2O-(R3O)m-M and a (polyether)alcohol R2O-(R3O)m-H, where R2 is hydrocarbon or hydrogen, R3 is hydrocarbon, M is alkali metal, m is 0 to 20 and n is 0 to 4.
Patent CA-2263286-A1 (CA)
Inventor: SEKIYA KOUICHI
IPC: C07F9/6561
Filed: 1997-08-12
Abstract: Phosphonate nucleotide compounds represented by general formula (I), their salts, hydrates and solvates thereof, and drugs containing the same, wherein R1 represents C1-6 alkyl, etc.; R2 represents hydrogen, halogenated C1-4 alkyl, etc.; R3 represents hydrogen, halogenated C1-4 alkyl, etc.; R4 represents hydrogen, halogenated C1-4 alkyl, etc.; and X represents carbon or nitrogen. These drugs are useful as antiviral agents for human immunodeficiency virus, herpes simplex virus, hepatitis B virus, etc., and as antitumor agents.
Patent CA-2264593-A1 (CA)
Title: Stepped filtration device for mechanically separating solids from liquids
Inventor: GIERSBERG ALFRED
IPC: E02B8/02
Filed: 1998-04-29
Abstract: A staged filter apparatus for mechanically separating solids from liquids flowing in channels, gutters or conduits, which has a multiplicity of stage screen bars connected to form a stationary grating, and a multiplicity of stage screen bars connected to form a movable grating, the gratings being arranged inclined in the direction of flow inside the flowing liquid starting from a level situated below the surface, and the stage screen bars being constructed in a stepped fashion in the direction facing the incoming flow, and in which the movable grating can be actuated by means of a drive device on a track which, starting from a zero position which is identical in the vertical and horizontal directions to the stationary grating, permits a stroke movement which rises over the stages of the stage screen bars connected to form the stationary grating and against the direction facing the incoming flow, and which reaches at least to a position identical in the vertical direction and in the horizontal direction to the next higher stage of the stationary grating, and subsequently guides the stage screen bars of the movable grating below the stationary grating back into the zero position, the stationary grating being surrounded at least laterally by frame parts, is distinguished in that all the drive elements of the movable grating are essentially arranged in the common plane formed by the stationary grating and the movable grating in the zero position.
Patent CA-2266416-A1 (CA)
Title: Insulin c-peptides
Inventor: WAHREN JOHN
IPC: A61K38/28
Filed: 1997-09-26
Abstract: The present invention relates to a peptide being a fragment of the human insulin C-peptide, said peptide comprising the sequence ELGGGPGAG or a fragment thereof, or the sequence EGSLQ or a fragment thereof, and having the ability to stimulate Na+K+ATPase activity. Further provided are biomimetic organic compounds exhibiting activation of Na+K+ATPase activity and/or cellular binding to renal tubule cells and fibroblasts at at least the level exhibited by the aforementioned peptides or their fragments. Such peptides and compounds have utility in combatting diabetes and diabetic complications, or for stimulating Na+K+ATPase activity.
Patent CA-2269614-A1 (CA)
Inventor: RENNERT PAUL D
IPC: A61K39/395
Filed: 1997-10-24
Abstract: Compositions and methods comprising "lymphotoxin-.beta. receptor blocking agents" which block lymphotoxin-~ receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
Patent CA-2273182-A1 (CA)
Inventor: GOCHT DIETMAR
IPC: F01K13/02
Filed: 1997-11-19
Abstract: The invention relates to a method for optimizing fossil-fueled power stations, whereby the operational and economic potential of a station is better used by determining the economic impact of changes made to selected operational parameters taking into consideration the economic expenditures required by said changes, and by deciding, on the basis of said additional operating costs, when and/or which measures should be taken to minimize additional operating costs.
Patent CA-2274612-A1 (CA)
Inventor: CHRISTMAS MICHAEL CHARLES
IPC: F16G13/06
Filed: 1997-12-10
Abstract: A drive chain has opposed pairs of inner link plates (3) that are interconnected by cast outer links (2). Pins (4) pass through aligned apertures in overlapping end portions of the inner and outer links. Each pin (4) is fixed relative to the inner link (1). The outer link (2) has open or blind bores (7) that receive end portions of the pins (4) in a pivotal relationship. A bearing area is defined between the outer surface of the pin (4) and an inner surface of the outer link bore (7). The provision of a bearing area in the outer link makes maintenance and sealing easier.
Patent CA-2275433-A1 (CA)
Inventor: HOELLER JAN
IPC: H04L12/54
Filed: 1997-12-19
Abstract: Narrowband based telephony services and associated value added services are provided transparently in a network providing ATM switching and no STM switching is required in an ATM network (625) to which units (601, 603) requiring such services are connected. This is obtained by means of, when a call enters the ATM network (625), first finding the output port (619) from the ATM network (625), then returning the address of that port to the entry port (617) and thereafter ATM switch the connection directly through the ATM network (625). Hereby bandwidth resources are more efficiently used since all switching is done by ATM regardless of application. Heavy investments in providing intelligent services support by existing systems can be reused in an efficient way and thus reduce time to market for the introduction of the value added services.