Patent SG-11201909058W-A (SG)
Title: Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers
Inventor: WALZ JULIANE SARAH
IPC: A61P35/00
Filed: 2018-04-10
Abstract: 00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPO I PCT omit VIII °nolo OH 1101 (10) International Publication Number WO 2018/189152 A3 (51) International Patent Classification: A61K 39/00 (2006.01) GO1N 33/50 (2006.01) C07K 14/47 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2018/059114 (22) International Filing Date: 10 April 2018 (10.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/483,690 10 April 2017 (10.04.2017) US 10 2017 107 710.3 10 April 2017 (10.04.2017) DE (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-StraBe 15, 72076 Tuebingen (DE). (72) Inventors: WALZ, Juliane Sarah; Gartenstrasse 71, 72076 Tuebingen (DE). KOWALEWSKI, Daniel; Den- zenbergstrasse 29, 72074 Tuebingen (DE). DUELER, Markus; Sandgrabenstr. 20, 72119 Ammerbuch (DE). DI MARCO, Moreno; Memmingerstr. 18/1, 72072 Tuebingen (DE). TRAUTWEIN, Nico; Pelargusstr. 2, 70180 Stuttgart (DE). NELDE, Annika; Viktor-Renner-StraBe 27, 72074 Tuebingen (DE). STEVANOVIC, Stefan; Auf der Burg 3, 72074 Tuebingen (DE). RAMMENSEE, Hans-Georg; Sommerhalde 3, 72070 Unterjesingen (DE). HAEN, Sebas- tian; Brombergstr. 15, 72070 Tuebingen (DE). (74) Agent: KRAUSS, Jan B.; Boehmert & Boehmert, Pet- tenkoferstrasse 20 - 22, 80336 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 22 November 2018 (22.11.2018) (54) Title: PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST LEUKEMIAS AND OTHER CANCERS (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.