baber/WOPTO huggingface dataset:
Patent RU-2753056-C2 (RU)
Title: Bicyclic heteroaryl derivatives as cftr stimulators
Inventor: STRONBECH DZHOZEF UOLTER
IPC: A61K31/53
Filed: 2017-12-14
Granted: 2021-08-11
Abstract: FIELD: pharmaceutics. 
     SUBSTANCE: invention relates to a compound of formula I or to its pharmaceutically acceptable salt. In formula I, Y is a five-element heteroaryl containing 2-3 heteroatoms, each of which is independently selected from a group consisting of N; Z is a phenyl, optionally substituted with 1 or 2 halogens; each R 1a  and R 1b  is independently selected from a group consisting of H, C 1 -C 6  alkyl. The invention also relates to the compound of formula II, to the compound of formula III, and to individual compounds.  
     EFFECT: technical result is that new compounds are obtained as a stimulator of the cystic fibrosis transmembrane conductance regulator (CFTR). 
     
       
     
     21 cl, 99 ex
Patent RU-2762293-C2 (RU)
Title: Antisense analgesic for scn9a
Inventor: CHUNG SHIN
IPC: A61P29/00
Filed: 2018-01-23
Granted: 2021-12-17
Abstract: FIELD: biotechnology. 
     SUBSTANCE: group of inventions relates to the field of biotechnology, in particular to derivatives of peptide nucleic acid targeted to 3'-section of exon 4 splicing in pre-mRNA of human SCN9A; it can be used in medicine. Derivatives of peptide nucleic acid actively induce options of splicing of SCN9A mRNA depleted in SCN9A exon 4 in mammalian cells, due to which they can be used for the safe treatment of different kinds of diseases or conditions involving activity of sodium-ion channels of Na V 1.7-type. 
     EFFECT: obtaining derivatives of peptide nucleic acid for the safe treatment of diseases. 
     16 cl, 24 dwg, 2 tbl, 22 ex
Patent RU-2764647-C2 (RU)
Title: Method for producing aluminum oxide
Inventor: Poselskaya Yuliya Vladimirovna
IPC: C01F7/02
Filed: 2019-11-19
Granted: 2022-01-19
Abstract: FIELD: chemical and technological processes. 
     SUBSTANCE: invention relates to chemical and technological processes, in particular to chemical methods for producing aluminum oxide from aluminum nitrate with highly ordered structure. The method for producing aluminum oxide includes pre-mixing of an aqueous solution of aluminum nitrate with a component increasing the homogeneity of the solution structure, and following heat-treating. As a component increasing the homogeneity of the solution structure, polyethylene glycol ether of isooctyl phenol (hereinafter – OP-10) is used, wherein 37.5 wt. % of an aqueous solution of aluminum nitrate is mixed with 39-49 wt. % of OP-10. The produced solution is hydrolyzed with ammonia vapor in a reactor with a vessel with 10 wt. % of ammonia solution. The produced product is washed in 96 wt. % of ethanol, and then dried at 80-90°C, and ignited at 440-460°C. 
     EFFECT: chemical activity of aluminum oxide is increased by increasing the homogeneity of mesopore size. 
     1 cl, 1 tbl
Patent RU-2742412-C2 (RU)
Inventor: HINRICHS RUTH
IPC: A61K8/362
Filed: 2015-12-17
Granted: 2021-02-05
Abstract: Группа изобретений относится к уходу за полостью рта. Композиция для ухода за полостью рта в виде ополаскивателя для рта содержит (i) по меньшей мере, один источник ионов олова, где концентрация ионов олова составляет от 0,01 до 0,10 вес.% в пересчёте на общий вес композиции для ухода за полостью рта в виде ополаскивателя для рта, (ii) по меньшей мере, одну алифатическую ди- или трикарбоновую кислоту в свободной или солевой форме, где по меньшей мере одна алифатическая ди- или трикарбоновая кислота представляет собой яблочную кислоту, взятую в количестве от 0,12 до 0,25 вес.% в пересчёте на общий вес композиции для ухода за полостью рта; (iii) от 0,06 до 0,33 вес.% аминофторида в пересчете на общий вес композиции для ухода за полостью рта в виде ополаскивателя для рта. Также раскрыты способ уменьшения уровней кислотообразующих бактерий и способ стабилизации ионов олова в композиции для ухода за полостью рта в виде ополаскивателя для рта. Группа изобретений обеспечивает стабильность композиции при хранении. 3 н. и 8 з.п. ф-лы, 4 табл., 2 пр.
Patent UA-73296-C2 (UA)
Title: Method for formation of secondary side stems in a well system and a well system
IPC: E21B41/00
Filed: 2000-01-02
Abstract: A method is disclosed for creating one or more secondary sidetracks in an oil and/or gas well assembly which comprises a primary wellbore (2) and one or more primary sidetracks (6) so that a root-like multilateral well structure is created. The method makes use of an expandable well liner (9) in the primary sidetracks (6) so as to create a liner having a sufficient internal width to allow sidetracking equipment to be inserted and operated in the primary sidetrack to drill and complete the secondary sidetracks (7).
Patent UA-72517-C2 (UA)
Title: Indolylpiperidine derivatives as antihistamine and antiallergenic agents
IPC: C07D401/04
Filed: 2000-05-31
Abstract: Indolylpiperidine compounds or formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoyl or hydroxyalkylene group; A2 represents a single bond, an alkylene or alkenylene group; W represents a single bond or a phenylene or furanylene group which is unsubstituted or substituted by one or more halogen atomns, alkoxy groups and/or alkyl groups: R2 Represents a hydrogen or halogen atom or an alkyl or alkoxy group, and R3 represents an carboxyl group o a tetrazolyl group. The present invention provides novel indolylpiperidine compounds having unproved antihistamine and antiallergic activity. (I).
Patent UA-73553-C2 (UA)
Title: Piperazine derivatives
Inventor: BLUMBERG LAURA COOK
IPC: C07D295/185
Filed: 2001-03-14
Abstract: A compound of formula (I) or the pharmaceutically acceptable salt thereof; wherein a, b, c, d, e, j, R1, R2, R3, and R4 are as defined above useful to treat inflammation and other immune disorders. (I)
Patent UA-85675-C2 (UA)
Title: For gas cook burner of improved type
Inventor: ARMANNI PIERO
IPC: F23D14/06
Filed: 2004-04-09
Abstract: The present invention refers to a model of gas cooker burner of improved type, which features a cap with a lower border situated near the notched crown of the border immediately above the section from which the mixture comes out and goes through the notches of the crown, which is provided with an external annular groove along the edge of the upper border.
Patent UA-79474-C2 (UA)
Title: Compound for treatment of textile materials
Inventor: MELNYK LIUDMULA OLEKSIIVNA
IPC: D06M15/00
Filed: 2005-01-12
Abstract: In compound for treatment of textile materials that includes silicon polymer base and solvent a compound based on low-molecular silicon rubber is used as silicon polymer base and Nefras as solvent.
Patent UA-84712-C2 (UA)
Title: N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
Inventor: BOLGER JOSHUA
IPC: A61K31/4184
Filed: 2004-08-16
Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
Patent UA-84181-C2 (UA)
Title: Support for rod-type device of external fixation
Inventor: LOMNYTSKYI OREST YAROSLAVOVYCH
IPC: A61F5/04
Filed: 2006-06-26
Abstract: The invention relates to medical devices, namely to a support for the rod-type device of the external fixation containing the solid metallic rod with the middle cylindrical bulge, the external canals and the equidistant notches on both ends of the rod, two adjustable screws with the recesses for the locking appliances located in the cylindrical cavities with the internal thread on both ends of the rod, and two external bushings with the cylindrical cavities with the internal diameter equaling the diameter of the solid metallic rod throughout the length of the bushing and the ledges entering the external canals of the solid metallic rod, and two locking appliances for the screws.
Patent UA-94892-C2 (UA)
Title: Column filling body structure for exchange of fluid and method for manufacture thereof
Inventor: BESSETTES REMI
IPC: B01J19/32
Filed: 2006-07-03
Abstract: The invention provides a column filling body structure for the exchange of fluid comprises an exchanger surface for at least one descending fluid phase contacted with at least one ascending gas phase. The characteristic features of structure consist in that it has a volume formed from rows of carbon composite tube bundles. Each bundle comprises four tubes, which are aligned in accordance with four diagonal direction of a cube, under the formation of an angle with the axle of the structure. The tubes form passages, which lead at the external surface of the structure.
Patent UA-91687-C2 (UA)
Title: opening device for sealed package containing pourable food product, sealed package containing pourable food product and method of formation opening device
Inventor: CASALE CRISTIANO
IPC: B65D5/74
Filed: 2005-10-08
Abstract: There is described an opening device (3) for a sealed package (1) containing a pourable food product and having at least one removable portion (7). The opening 5 device (3) has a frame (10) defining a pour opening (11) and having a fastening portion (17) fixable to the package (1) about the removable portion (7); a cap (12) fitted to the frame (10) to close the pour opening (11), and removable from the pour opening (11) to permit pour- 10 out of the food product; and an anchoring portion (13), which engages the pour opening (11), is fixable directly to the removable portion (7), and is removable from the pour opening (11) to at least partly detach the removable portion (7) from the package (1); and the anchoring 15 portion (13) is connected integrally to the frame (10) by means of breakable connecting means (23), and is connected to the cap (12) so as to move together with the cap when removing the cap (12) from the pour opening (11).
Patent UA-83586-C2 (UA)
Title: Amorphous double salt zinc-cadmium aquaaminoorthophosphate and process for preparation thereof
Inventor: KOPILEVYCH VOLODYMYR ABRAMOVYCH
IPC: C01B25/45
Filed: 2007-03-14
Abstract: The invention relates to new chemical coordinative structure compounds, namely to amorphous double salt zinc-cadmium aquaaminoorthophosphate in solid state of general formula ZnCd(PO)·n(NH)·m(HO), where x=0.6-2.4; n=1.3-3.1; m=2.3-3.4, which can be used for the luminophor preparation. A process for the preparation of amorphous double salt zinc-cadmium aquaaminoorthophosphate, in which fixed ratio between the content of Znand Cdis achieved by solving of mechanical mixture of crystal compounds Zn(PO)·4HO and Cd(PO)·5HO, taken in mole ratio Zn:Cd from 2.4:0.6 to 0.6:2.4, in excess of concentrated water solution with a further solid compound deposition by means of phosphate ammonia solution infusion to the acetone and its holding in air at 15-25 ºС to complete hardening and constant mass.
Patent UA-92168-C2 (UA)
Title: Method for microclonal propagation of hop regenerants grown of apexes in vitro
Inventor: KORMILTSEV BORYS FEDOROVYCH
IPC: A01H4/00
Filed: 2007-10-25
Abstract: The invention relates to a method for microclonal propagation of hop regenerants grown of apexes in vitro such that in sterile conditions a single hop regenerant is divided into microcuttings according to the number of internodes, the length of lamini is shortened, a nutrient medium with micronutrients is formed according to the Murashige and Scoog formulation, macronutrients, vitamins as thiamine-HC, pyridoxine-HC and mesoinosite, a source of carbohydrates, phytohormones as β-indoleacetic acid, agar-agar. The microcuttings are made of sizes of 10- with a length of lamini of 0.5-1.0 of the length of a microcutting, the nutrient medium is formed with micronutrients according to the Murashige and Scoog formulation: HBO– 6.0-6.5 mg/l, MnSO*4HO – 22.0-22.5 mg/l, CoCl*6HO – 0.020-0.030 mg/l, CuS0*5HO – 0.20-0.030 mg/l, ZnS0*7HO – 8.0-9.0 mg/l, NaMoO*2HO – 0.20-0.30 mg/l, KJ – 0.80-0.90 mg/l, with macronutrients according to the Nitsch and Nitsch formulation: KNO- 940-960 mg/l, NHNO– 710.0-730.0 mg/l, MgSO*7HO – 180.0-190.0 mg/l, CaCl– 160.0-170.0 mg/l, KHPO– 60.0-75.0 mg/l, MnSO*4HO – 20.0-30.0 mg/l, FeS0*7HO – 27.0-28.0 mg/l, NaEDTA*2HO – 37.0-38.0 mg/l. In doing so the vitamins are supplemented with folic acid in an amount of 1-5 mg/l, and thiamine-HC is made in an amount of 1-5 mg/l, pyridoxine-HC - 1-5 mg/l, mesoinosite - 80-120 mg/l. In addition glucose in an amount of 20-40 g/l is used as a source of the carbohydrates with kinetin in an amount of 0.05-0.5 mg/l, and β-indoleacetic acid - 6-15 mg/l additionally used as the phytohormones. In doing so the microcuttings are grown on a nutrient medium at a temperature of +23-27 ºC, an illumination intensity of 1.5-3 kiloLux, at a 14-17 hour light period up to forming a rooted microseedling, further the process is repeated up to obtaining the required number of microseedlings. The latters are planted in a peat-sand mixture in a ratio 3:1-3:2 with a pH of 5.5-6.5, a moisture content of 40-70%, preliminary having removed the residues of the nutrient medium from the root system and having carried out treatment of the latter in a fungicide. The method excludes a possibility of forming callus tissue in hop plants, provides varietal stability of the material being propagated, allows propagating both aromatic and bitter hop varieties.
Patent UA-92490-C2 (UA)
Title: Imidazoquinolines as lipid kinase inhibitors
Inventor: GARCIA-ECHEVERRIA CARLOS
IPC: A61P35/00
Filed: 2006-05-18
Abstract: The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
Patent UA-94709-C2 (UA)
Title: Method for the preparation of 3,3',4,4'-tetraaminobiphenyl
Inventor: YASUDA HIROSHI
IPC: C07C209/28
Filed: 2007-12-05
Abstract: The object of the present invention is to provide an efficient method of manufacturing 3,3',4,4'-tetraaminobiphenyl with a smaller number of steps. The manufacturing method of 3,3',4,4'-tetraaminobiphenyl includes reacting the amino groups of a 4-halo-o-phenylenediamine with an inorganic sulfur compound to lead to a 5-halo-2,1,3-benzothiadiazole, subsequently coupling two molecules of the benzothiadiazole together to form a 5,5'-bis(2,1,3-benzothiadiazole) and then deprotecting the amino groups to yield 3,3',4,4'-tetraaminobiphenyl.
Patent UA-100001-C2 (UA)
Title: Method for the reduction of the body excessive weight
Inventor: MUKHINA MARIYAT MURADALIYEVNA
IPC: A61H39/00
Filed: 2006-07-19
Abstract: The invention relates to medicine, in particular to acupuncture reflexotherapy. The inventive method consists in introducing a needle provided with a three-dimensional, plate- or ring-shaped head into the specified, for example, auricular acupuncture point of a patient, in extracting the needle free end from another specified point and in fixing a removable plate-shaped or three-dimensional retainer thereto. Said retainer can be embodied in such a way that it is fixable and formed by the curved free end of the needle stem. A desired reduction of the body weight is obtainable by exposing said point areas to the head and/or retainer weight, and/or by modifying the contact area thereof with said points, and/or by modifying the progradient correlation of the action intensity on said points. In order to enhance the action, pins and suspensions on the head of retainer or shaped and/or wavelike needle surface are used. The inventive method and the needle structural design make it possible to more efficiently act on the selected acupuncture points, thereby substantially reducing the patient body excessive weight or treating the diseases thereof.
Patent UA-103457-C2 (UA)
Title: Method of producing a comestible
Inventor: COLLIN SONIA
IPC: C12C7/00
Filed: 2007-12-07
Abstract: A method of producing a comestible by adding spent hop material during the production of the comestible, wherein the stilbenes and flavanoids contained in the spent hop material act as quenchers of oxygen resulting in an improved flavor stability of the comestible, and wherein the surviving stilbenes present in the comestible provide additional anti-oxidative properties to the comestible, leading to health benefits for the consumer.
Patent UA-97293-C2 (UA)
Title: Method for isolation of microalgae phaeodactylum tricornutum (bacillariophyta) algoviruses from sea water samples
Inventor: STEPANOVA OLHA ARSENTIIVNA
IPC: C12N1/12
Filed: 2010-04-06
Abstract: A method of isolation of microalgae Phaeodactylum tricornutum (Bacillariophyta) algoviruses from sea water samples, comprising inoculation of indicator cultures of microalgae with sea water samples, wherein investigation of water samples is carried out after storage thereof for 8-43 days.
Patent UA-105908-C2 (UA)
Title: High-strength propping agents
Inventor: SAN-MIGUEL LAURIE
IPC: C04B35/14
Filed: 2009-10-30
Abstract: A sintered ceramic particle made from a ceramic material having a true density greater than 3.5 g/cc and a composition having no more than 30 weight percent silicon oxide and at least 15 weight percent iron oxide, based on the combined weight of the oxides of aluminum, iron and silicon, is disclosed.
Patent UA-104332-C2 (UA)
Title: Multi-layer film structure and blister package made from it
Inventor: BELLAMAN STEPHEN J
IPC: B65D75/36
Filed: 2010-01-09
Abstract: A multi-layer film structure (10) for use in forming blister packaging includes a first polymeric layer (12) having a first surface (14) and a second surface (16), the first polymeric layer (12) comprising a metalized polyethylene teraphthalate. The multi-layer structure (10) also includes a second polymeric layer (24) having a first surface (26) and a second surface (28), the first surface (26) of the second polymeric layer (24) disposed adjacent the second surface (16) of the first polymeric layer (12), the second polymeric layer (24) comprising a cyclic olefin or a homopolymer of chlorotrifluoroethylene. The multi-layer structure (10) further includes a third polymeric layer (36) having a first surface (38) and a second surface (40), the first surface (38) of the third polymeric layer (36) disposed adjacent the second surface (28) of the second polymeric layer (24), the third polymeric layer (36) comprising polypropylene or polyvinyl chloride. A method of making a multi-layer film structure (10) and a thermoformed blister package (100) are also provided.
Patent UA-108743-C2 (UA)
Title: Похідні хіназолін-4(3н)-ону для застосування як інгібіторів рі3-кінази
IPC: A61P35/00
Filed: 2010-10-19
Abstract: Даний винахід стосується сполук формули (І)(I)і композицій, що містять ці сполуки, застосування цих сполук і їх композицій у лікуванні, наприклад у лікуванні запальних хвороб, зокрема респіраторного запального захворювання.Винахід також поширюється на способи отримання вказаних сполук.
Patent UA-106931-C2 (UA)
Title: Гідросівалка олега коновала для пророщеного насіння
IPC: A01C7/00
Filed: 2013-03-20
Abstract: Заявлена гідросівалка для пророщеного насіння містить цистерну з вихідним отвором, наділеним запірним органом і сполученим трубопроводом з розподільною камерою, з'єднаною шлангами з сошниками, та розміщену в цистерні систему постійного самозабору посівної суміші, що включає наділену поплавком місткість у вигляді чаші для самозабору водонасіннєвої суміші через декілька отворів у дні чаші, більших за розміри насінин, та витік її через вихідний калібрований отвір знизу чаші, яка з'єднана за допомогою гнучкого трубопроводу з вихідним отвором в цистерні. Місткість виконана у вигляді плаваючої ампули, яка має кришку зверху і отвори знизу, розмір яких менше розміру насінин, що дозволяє служити ампулі в ролі місткості для завантаження в неї порції пророщеного насіння. Над вихідним каліброваним отвором в ампулі виконано наділений клапаном отвір для надходження через нього потоку води в ампулу при роботі сівалки. В гнучкому трубопроводі, що знаходиться в воді, виконано отвір для додаткового забору води з цистерни.
Patent UA-110506-C2 (UA)
Inventor: GOSIEWSKI KRZYSZTOF
IPC: F23N1/00
Filed: 2011-08-12
Abstract: Спосіб утилізації низькоконцентрованих сумішей горючий газ - повітря зі стабільною рекуперацією теплової енергії включає спалювання, з регенерацією тепла, сумішей в реверсивному пристрої. Стабільну рекуперацію тепла та симетричний профіль температури у пристрої підтримують, вибираючи момент зміни напрямку потоку безпосередньо в залежності від різниці температур пари секцій спалювання, забезпечуючи різний час півциклу у кожному напрямку потоку та у кожному півциклі, та вибираючи швидкість потоку гарячого газу, подаваного по трубопроводах у пристрій (22) для рекуперації тепла. Реверсивний пристрій для здійснення даного способу містить щонайменше одну пару секцій спалювання, щонайменше один внутрішній нагрівальний пристрій, датчики температури і складу газу, елементи системи автоматичного регулювання, реверсивний клапан. Кожна з секцій містить структурне заповнення з монолітних блоків з невеликими трубками, які характеризуються низьким опором потоку. Секції спалювання оснащені симетрично розташованими датчиками температури.
Patent UA-119457-C2 (UA)
Title: Method and device for preparing aluminium-coated steel sheets intended for being welded and then hardened under a press; corresponding welded blank
Inventor: SCHMIT FRANCIS
Filed: 2015-04-17
Abstract: The invention relates to a method for preparing sheets intended for manufacturing a steel welded blank, which comprises the following consecutive steps: providing at least one first (11) and one second (12) pre-coated steel sheets, made up of a steel substrate (25, 26), and a pre-coating (15, 16) made of an intermetallic alloy layer (17, 18) in contact with said steel substrate, mounted on top of a aluminium, aluminium-alloy or aluminium-based metal layer (19, 20), the sheet (11) comprising a main surface (111), an opposing main surface (112), and at least one secondary surface (71), the sheet (12) comprising a main surface (121), an opposing main surface (122), and at least one secondary surface (72); then moving the first (11) and second (12) sheets close together, leaving a clearance (31) of 0.02 to 2 mm between the secondary surfaces (71) and (72) placed lacing one another, the fact of moving the first (11) and second sheets (12) together defining a median plane (51) perpendicular to the main surfaces of the sheets (11) and (12); and then simultaneously removing by melting and vaporisation, on the main surface (111) and the main surface (121), the layer of metal alloy (19) in a peripheral area (61) of the sheet (11), and the layer of metal alloy (20) in a peripheral area (62) of the sheet (12), the peripheral areas (61) and (62) being the areas of the main surfaces (111) and (121) that are closest to said median plane (51) located on either side of same. The invention also relates to a welded blank and to a device for manufacturing such welded blanks.