Patent SG-11201903055U-A (SG)
Title: Inhibitors of glucocorticoid receptor
Inventor: SUN DAQING
IPC: C07J41/00
Filed: 2017-10-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) WIPO I PCT omit VIII °nolo olliolu No oimIE (10) International Publication Number WO 2018/068021 Al (51) International Patent Classification: C07J 17/00 (2006.01) CO7J 43/00 (2006.01) C07J 41/00 (2006.01) CO7J 51/00 (2006.01) (21) International Application Number: PCT/US2017/055660 (22) International Filing Date: 06 October 2017 (06.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/405,801 07 October 2016 (07.10.2016) US 62/526,331 28 June 2017 (28.06.2017) US (71) Applicant: ORIC PHARMACEUTICALS, INC. [US/US]; 240 E. Grand Avenue, 2nd Floor, South San Fran- cisco, California 94080 (US). (72) Inventors: SUN, Daqing; 804 Cortez Lane, Foster City, California 94404 (US). MCGEE, Lawrence R.; 39 Big Sur Way, Pacifica, California 94044 (US). DU, Xiaohui; 2735 Wemberly Drive, Belmont, California 94002 (US). ZHU, Liusheng; 752 Orion Lane, Foster City, California 94404 (US). YAN, Xuelei; 1120 Nimitz Lane, Foster City, Cal- ifornia 94404 (US). REW, Yosup; 828 Juno Lane, Fos- ter City, California 94404 (US). EKSTEROWICZ, John; 1845 Church Street, San Francisco, California 94131 (US). MEDINA, Julio C.; 2879 Roland Ave, San Carlos, Cali- fornia 94070 (US). FANTIN, Valeria R.; 3133 Frontera Way, Apt 217, Burlingame, California 94010 (US). ZHOU, Haiying; 280 San Felipe Ave, Apt 3, San Bruno, Califor- nia 94066 (US). BALBAS, Minna Delarae; 615 Monterey Blvd, Apt 2, San Francisco, California 94127 (US). (74) Agent: SMITH, Deborah M.; WILSON SONSINI GOODRICH & ROSAIT, 650 Page Mill Road, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 1-1 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 O 00 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) © (54) Title: INHIBITORS OF GLUCOCORTICOID RECEPTOR (57) : The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided 0 herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject cam- \" pounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions 0 are useful for the treatment of cancer.