baber/WOPTO huggingface dataset:
Patent IL-80710-A0 (IL)
Title: Recombinant dna expression vectors and dna compounds that encode isopenicillin n synthetase from penicillium chrysogenum
IPC: C12R1/75
Filed: 1986-11-20
Abstract: The present invention comprises novel DNA com­pounds that encode isopenicillin N synthetase. The invention also comprises methods, transformants, and polypeptides related to the novel DNA compounds. The novel isopenicillin N synthetase-encoding DNA, together with its associated transcription and translation activating sequence, was isolated from Penicilliumchrysogenum. The isopenicillin N synthetase-encoding DNA can be used to construct novel E. coli expression vectors that drive expression of isopenicillin N syn­thetase in E. coli. The intact P. chrysogenum iso­penicillin N synthetase-encoding DNA and associated transcription and translation activating sequence can also be used to construct expression vectors that drive expression of the isopenicillin N synthetase in P. chrysogenum and Cephalosporiumacremonium. The transcription and translation activating sequence can be fused to a hygromycin phosphotransferase-encoding DNA segment and placed onto expression vectors that function in P. chrysogenum and C. acremonium. The transcription termination and mRNA polyadenylation signals of the P. chrysogenum isopenicillin N synthetase can be used to increase ultimate expression of a product encoded on a recombinant DNA vector.
Patent IL-85940-A0 (IL)
Title: Substituted 5-pyridyl-1,3,4-oxadiazoles and-thiadiazoles,their preparation and their use as nematicides
IPC: C07D413/04
Filed: 1988-03-31
Abstract: There are described 2-mercapto-5-pyridyl-1,3,4-oxadiazoles and 2-mercapto-5-pyridyl-1,3,4-thiadiazoles of the formula I 
<IMAGE>
 in which
 X represents oxygen or sulphur,
 R' represents C1-C3-alkyl which is substituted by bromine, fluorine, C1-C3-alkoxy or cyano, C3-C7-alkenyl which is unsubstituted or substituted by halogen; C4-C7-alkynyl which is unsubstituted or substituted by halogen,
 R represents C1-C3-alkyl, C1-C3-alkoxy which is unsubstituted or substituted by halogen or C1-C3-alkoxy; C3-C7-alkenyl which is unsubstituted or substituted by halogen; C3-C7-alkynyl, C1-C3-alkylthio, halogen, cyano, hydroxyl, amino which is unsubstituted or monosubstituted or disubstituted by C1-C3-alkyl; or aminocarbonyl, and
 n represents 0, 1, 2, 3 or 4, the process for the preparation of the compounds of the formula I, and novel intermediates of the process. 
<??>The compounds of the formula I have nematicidal properties. There are described nematicidal agents which contain, as active substance, at least one active substance of the formula I, and furthermore processes for the use of the active substances and the agents in the control of nematodes.
Patent IL-92190-A0 (IL)
Title: Liquid oral formulation
IPC: A61K9/107
Filed: 1989-11-02
Abstract: The invention relates to an aqueous oral pharmaceutical formulation of diclofenac, which can be used for treating pain and inflammatory processes, and also to the preparation of such a formulation.
Patent IL-92817-A0 (IL)
Title: Substituted guanidine and amidine compounds,their production and fungicidal compositions containing same
IPC: A01N43/54
Filed: 1989-12-20
Abstract: The present invention concerns novel substituted guanidine and amidine compounds, their preparation and their use in the kill and control of fungal organisms which infest plants.
Patent SE-8205222-A0 (SE)
Title: Anordning vid reglerdon och liknande
Inventor: KARLSSON B A
IPC: H02P25/24
Filed: 1982-09-13
Abstract: Uppfinningen avser sadana anordningar, sarskilt stalldon och liknande, som manovreras medelst en elektrisk motor. Den loser problemet att eliminera behovet av granslagesbrytare far motorns (M) matningsstrOm. Detta mojliggors genom att, nar det rorliga organet narmar sig ett andlage, stromstyrkan genom motorn automatiskt begransats till ett sadant varde att strommen inte behtiver brytas utan kan ligga kvar sgsom en vilostrem till dess anordningen nasta gang skall aktiveras. Begransningen sker med hjalp av motstand (6, 7), vilka inkopplas i motorns strommatningskrets och vilkas resistans ar temperaturberoende.
Patent SE-8301734-A0 (SE)
Title: Käpp
Inventor: MICHAEL FLADDA
IPC: A61H3/02
Filed: 1983-03-29
Abstract: Uppfinningen avaex en kapp av det slag som anvands parvis (8,9) som gAnghj.41p av personer med skador eller svaghet i benen. PA handtagets ytterande och/eller pa andarna av en gripdel. fOt• stod fOr armarna finns ett magnetarrangemang med :tvá utAt verkande magnetpoler med motsatt polar: et placerade längs med en limb e som stracker sig vasentligen tvars tot kappens utstrackning. TvA kappar, som satts ihOp med handtagen vanda mot varandra, kan sedan stallas mot -.en vagg e.d. utan att ramla omkull.
Patent FI-20020752-A0 (FI)
IPC: F02M25/028
Filed: 2002-04-19
Abstract: A spraying head for the humidification of intake air of a piston engine has a body and channels for supplying a spraying medium from an inlet to nozzles. A shutting/regulating mechanism respectively shuts off/regulates the channels.
Patent FI-20116031-A0 (FI)
Inventor: TYYBAEKINOJA JARNO
IPC: A45F/
Filed: 2011-10-18
Abstract: The invention relates to a baton holster, which baton holster (10) includes a cylindrical body part (16) for keeping a baton (14), an attachment (13) attached to the body part (16), and locking means (18) for locking the baton (14) into the body part (16). The baton holster (10) further includes a frame (20), which is arranged to be locked at least partly on top of the said baton (14). The invention also relates to an arrangement in a baton holster.
Patent IL-110487-A0 (IL)
Title: Photocrosslinked polymers
IPC: B29D11/00
Filed: 1994-07-28
Abstract: Prepolymer (P) comprising a polyvinyl alcohol derivative with a molecular weight of at least ca. 2000 and containing ca. 0.5-80 % groups of formula (I) with respect to the number of OH groups : R = 1-8C alkylene ; R<1> = H or lower alkyl ; and R<2> = olefinic unsaturated electrophilic copolymerisable group preferably containing up to 25C atoms. Also claimed are (i) polymers prepared by photo-cross-linking of (P), optionally in the presence of additional vinyl monomers, (ii) the preparation of these polymers by the same method, (iii) moulded articles comprising these polymers, and (iv) the preparation of the moulded articles by photo-cross-linking (P), optionally in the presence of additional vinyl monomers, in a closed mould.
Patent IL-110513-A0 (IL)
Title: Stabilized pharmaceutical compositions containing buproprion
IPC: C07C225/10
Filed: 1994-07-29
Abstract: PCT No. PCT/GB94/01642 Sec. 371 Date Mar. 22, 1996 Sec. 102(e) Date Mar. 22, 1996 PCT Filed Jul. 29, 1994 PCT Pub. No. WO95/03791 PCT Pub. Date Feb. 9, 1995This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
Patent IL-113261-A0 (IL)
Title: Inhibition of lymphocyte adherence to vascular endothelium utilizing a novel extracellular matrix receptor-ligand interaction
IPC: A61K39/44
Filed: 1995-04-05
Abstract: The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand. The invention is based upon the discovery that the  alpha 4 beta 1 extracellular matrix receptor promotes adhesion of lymphocytes to endothelial cells via attachment to a defined peptide sequence. Prior to the present invention, the ligand of the  alpha 4 beta 1 receptor had not been identified, nor had the function of the  alpha 4 beta 1 receptor in lymphocyte attachment been known. By preventing the interaction between the  alpha 4 beta 1 receptor and its ligands using antibodies or defined peptide sequences, the present invention enables, for the first time, specific intervention in the migration of lymphocytes through the vascular endothelium and into tissues. The present invention, therefore, has particular clinical utility in suppression of the immune response, in various specific embodiments of the invention, the adherence of lymphocytes to endothelium may be inhibited systemically, or may, alternatively, be localized to particular tissues or circumscribed areas. Accordingly, the present invention provides for treatment of diseases involving autoimmune responses as well as other chronic or relapsing activations of the immune system, including allergy, asthma, and chronic inflammatory skin conditions.
Patent IL-117319-A0 (IL)
Title: Recyclable medication dispensing device
IPC: A61M5/20
Filed: 1996-02-29
Abstract: A multi-use pen-shaped medication dispensing device (20) made of a plastic material that is recyclable after the contents of the medication cartridge (40) have been exhausted. The device (20) is made of a minimal number of parts, which include a housing (22), a dial assembly (34), a generally cylindrical button assembly (32) located within the proximal end (50) of the dial assembly (34), an internally threaded nut (36), and an externally threaded leadscrew (38). The device (20) is arranged so that the dial (34) must be rotated to the zero dose position prior to setting a dose. The device (20) includes a lockout mechanism (52) that prevents the dial (34) from being depressed during dosing. The device (20) further includes a mechanism (157) that limits the maximum dosage that can be dialed up, a mechanism (230,234) that prevents the user from dialing up a dosage greater than that remaining in the cartridge (40) and means (182,184,204) for maintaining the leadscrew (38) in engagement with a piston (210). <IMAGE>
Patent IL-118750-A0 (IL)
Title: 1-Acylpiperidine compounds
IPC: A61P43/00
Filed: 1996-06-27
Abstract: 1-Acylpiperidine compound of the formula I    <IMAGE>  (I)  in which R1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl radical or the acyl radical of an  alpha -amino acid which is optionally N-substituted by lower alkanoyl or carbamoyl-lower-alkanoyl, R2 is cycloalkyl or an optionally substituted aryl or heteroaryl radical, R3 is hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl radical which is optionally substituted by carboxyl or esterified or amidated carboxyl, R4 is an optionally substituted aryl or optionally partially hydrogenated heteroaryl radical, X1 is methylene, ethylene, a direct linkage, an optionally ketalised carbonyl group or an optionally etherified hydroxymethylene group, X2 is alkylene, carbonyl or a direct linkage, and X3 is carbonyl, oxo-lower-alkylene, oxo(aza)-lower-alkylene or an alkylene radical which is optionally substituted by phenyl, hydroxymethyl, optionally esterified or amidated carboxyl or, in higher than the  alpha  position, by hydroxyl, and its salts have substance-P-antagonistic properties and can be used as pharmaceutically active substances in pharmaceuticals for the treatment of disorders in whose development substance P plays an essential part.
Patent IL-121272-A0 (IL)
Title: Nucleotide comprising compositions and their use for improving therapeutic index of a therapeutic drug
IPC: A61K31/7076
Filed: 1997-07-10
Abstract: Adenosine and active agent which interact with the adenosine system are used to treat conditions of weakened, immune system, as an anti-cancer therapy and for improving the therapeutic index of a variety of therapeutic drugs.
Patent IL-139040-A0 (IL)
Title: Efficient purification of adenovirus
IPC: C12N7/02
Filed: 1999-04-22
Abstract: A method of enriching a solution for an adenovirus comprising contacting a solution containing an adenovirus with an anion exchange chromatography resin comprising an acrylate or sulphonamide linker such that the adenovirus binds to the chromatography resin and eluting the adenovirus from the resin with an eluant to obtain an enriched solution of adenovirus.
Patent IL-146722-A0 (IL)
Title: Communications protocol for packet data particularly in mesh topology wireless networks
IPC: H04L12/56
Filed: 2000-06-05
Abstract: In a wireless mesh topology data communications network, a communications method having a type of handshaking protocol for data exchange. A portion of the protocol is synchronous, using a schedule of control channel sessions held at all mutually communicating nodes of the network and a portion of the protocol is asynchronous, relying upon gaps between control channel sessions for transmission of requested data. Nodes (A, B) which are in line of sight relation request data from each other using a request to send (RTS) message and a clear to send (CTS) message. A requesting node sends an RTS message to a neighbor node with information about gaps specifying the location of requested data. A supplying node transmits a potential schedule for sending requested information and the requesting node sends a CTS message agreeing upon the schedule. The potential schedule includes a number of available gaps between known control channel sessions. Because transmissions are scheduled, rapidly switchable directional antennas at requesting and supplying nodes may be used with good advantage. <IMAGE>
Patent IL-152672-A0 (IL)
Title: Sphingosine kinase and uses thereof
IPC: A61K35/14
Filed: 2001-05-11
Abstract: The present invention relates generally to a method of modulating the growth of cells and, more particularly, to a method of down-regulating the growth of neoplastic cells. The present invention is useful, inter alia, in the therapeutic and/or prophylactic treatment of cancers such as, but not limited to, solid cancers such as cancers of the colon, stomach, lung, brain, bone, oesophagus, pancreas, breast, ovary or uterus.
Patent IL-161113-A0 (IL)
Title: Method and apparatus for multi-channel reverse link outer-loop power control
IPC: H04W52/14
Filed: 2002-09-24
Abstract: In a disclosed embodiment, a maintain and adjust threshold module determines the desired signal to noise and interference ratio for a first channel. Next, a delta computation module produces a threshold delta, which is then added to a base threshold by way of an adder. The resulting sum is the outer-loop set point that is used in a comparator. The comparator compares a receive signal strength with the outer-loop threshold. The comparator output is inputted to a generate up/down command module. The generate up/down command module sends a down command to the mobile unit if receive signal strength is greater than the outer-loop threshold, otherwise it sends an up command.
Patent IL-175468-A0 (IL)
Title: Longitudinally reinforced cured in place liner
IPC: B29C63/00
Filed: 2006-05-07
Abstract: A longitudinally reinforced resin impregnated cured in place liner with a reinforcing scrim to limit longitudinal stretch is provided. A continuous length of resin impregnable tube is provided in lay flat condition, impregnated with resin and a scrim having greater strength in the warp direction than in the weft direction is placed on a portion of the bottom of the tube that is then feed into a tubular former where an impermeable film is formed into a tube sealed and continuously everted about the inner tubular member and scrim traveling in an opposite direction so that the everted wrapping envelopes the tubular member. The reinforced tube may have an integral inner impermeable layer that is installed in an existing pipeline by the pull-in-and-inflate method.
Patent IL-178548-A0 (IL)
Title: Derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, and applications thereof
IPC: C07D461/00
Filed: 2006-10-15
Abstract: The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical -AR' wherein A represents a heteroatom and R' represents a group selected from the group comprising linear or branched C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl radicals, C<SUB>2</SUB>-C<SUB>6 </SUB>alkenyls, C<SUB>2</SUB>-C<SUB>6 </SUB>alkynyls, arylalkyls; esters comprising the formula -R<SUB>1</SUB>- CO-O-R<SUB>2</SUB>; amides comprising the formula -R<SUB>3</SUB>-CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof. The invention also relates to the use of the novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep-wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.
Patent RO-129389-A0 (RO)
Title: Drive mechanism transmitting the rotary motion with torque increase
Inventor: BĂTĂUŞU ILIE
IPC: F16H41/00
Filed: 2013-09-03
Abstract: The invention relates to a mechanism for driving and transmitting the rotary motion, which is destined to a hydraulic turbine. According to the invention, the mechanism comprises a support (1) in which there is placed a shaft (2) which receives the motion by means of a chain gearing or a toothed belt gearing (3) and transmits said motion to some wheel or toothed belt segments (4) which ensure the circular gearing continuity of a toothed crown (A), each segment (4) belonging to a lever-type construction (5), which is supported in the middle by means of the surface of a channel (a) wherethrough the transmission shaft (2) passes with a smooth part (b), the end of the lever (5) is mounted on a bolt (6), which together with other bolts (6) helps the mounting of the other toothed wheel segments (4), the fastening is performed by means of two plate disks (7 and 8) which enable some tangential forces to occur, said tangential forces together with the useful tangential force within an active branch (c) of the gearing (3) allow the obtaining of an increased torque transmitted further by two wedges (9 and 10) to the transmission shaft (2) fixed by means of two bearings (11 and 12) in the support (1).
Patent RO-131074-A0 (RO)
Title: Capacitor structure for non-volatile memory, based on germanium nanocrystals immersed in silicon dioxide
Inventor: CIUREA LIDIA MAGDALENA
IPC: H01L29/792
Filed: 2015-11-19
Abstract: The invention relates to a capacitor structure for a non-volatile memory, based on Ge nanocrystals immersed in SiOand to a process for preparing the same, said structure being meant to be used in microelectronics. The structure, as claimed by the invention, consists of a number of three layers deposited on a carrier wafer (1) of Si (100), of type p, with a resistivity ranging between 5...15 Ω x cm, as follows: a SiOtunnel layer (2) with a size ranging between 3...6 nm, a layer (3) of Ge nanocrystals in SiO, with a size ranging between 7...8 nm and a last SiOcontrol layer with a size ranging between 20...25 nm. The process, as claimed by the invention, has the following steps: cleaning the Si carrier wafer (1) with a Piranha solution at 65°C, treating with ultrasounds in deionized water for 45 min, then immersing it into a HF diluted solution for 15...60 s, drying in a flow of N; thermally growing the SiOtunnel layer (2) at a temperature ranging between 950...1000°C by rapid thermal oxidation, under a mixed atmosphere of Ar and O; depositing the Ge intermediate layer (3) and SiOcontrol layer (4) under Ar atmosphere, at a working pressure of 4 mTorr, using magnetron sputtering, followed by a thermal treatment in Ar, at a temperature of 1000°C, for forming the intermediate layer with Ge nanocrystals, with a density in the range of 10cm, immersed in SiO.
Patent RO-133515-A0 (RO)
Title: Process and plant for preparing hot water for consumption
Inventor: RADU NICOLAE
IPC: E03B7/07
Filed: 2019-01-30
Abstract: The invention relates to a process and a plant for preparing hot water for consumption, meant to provide hot water for public utility services through the centralized thermal energy supply system SACET, aiming at improving the system performance indicators by increasing reliability, efficiency and yields, proposing the process of providing the customers with a single utility service, i.e. heat carrier. According to the invention, the process ensures, through the service provider, two independent public utility services, in the centralized thermal energy supply system SACET, where the first one is the heat carrier for heating and the second component is recycled hot water, both being distributed through a system of four pipes which are parallelly arranged in thermal channels, up to the property confining zone, providing the customers with a single utility service, i.e. the heat carrier, for 365 days, 24 h/day, the working parameters being ensured by the service provider, as follows: P= 4.5 bar - constant; variable temperature from a minimal value T=57°C to a maximum value T=70°C. The plant, as a solution for the claimed process, provides the heat carrier as an energy source in the primary circuit of a heat exchanger (1) with plates, having mounted on the cold water inlet in the secondary circuit of the heat exchanger (1) an automatic pressostat (2) which, upon opening a hot consumption water discharge valve (3), makes the pressure in the outlet of the secondary circuit of the exchanger (1) drop, the pressostat (2) controlling the opening of the valve (3) by means of an electro-thermal servomotor (4) with two-point regulation, opening the by-pass circuit which, after previously venting the primary circuit in the venting point (5), initiates hot water preparation, either independent or parallel with the heating circuit, the flow rate of which may be adjusted or closed by means of some valves (6 and 7).
Patent IE-910908-A1 (IE)
Title: Substituted purines, processes for their preparation and¹their use as antiviral agents
IPC: C07D473/20
Filed: 1991-03-19
Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.