baber/WOPTO huggingface dataset:
Patent SK-14597-A3 (SK)
Title: A method for producing particulated detergent composition and detergent composition or its component made by this method
Inventor: DHALEWADIKAR SHASHANK V
IPC: C11D11/04
Filed: 1995-07-24
Abstract: Production method for particulate detergent mixture with bul k density in the range 350 to 650 g/l, comprises dosage of the pa rticulate material, which contains neutralizing agent and selecta ble detergent builder, into the fluidising zone, fluidising the m aterial, contacting the liquid acid precursor of the anionic surf ace active substance, with fluidised material to perform at least partial and preferably complete neutralization of the acid precu rsor and for production of detergent particles, which contain neu tralized acid precursor.
Patent SK-16299-A3 (SK)
Title: Inhibitors of cysteine protease, method for their producing, pharmaceutical composition them containing and their use
Inventor: MARQUIS ROBERT W
IPC: A61P21/00
Filed: 1997-08-07
Abstract: This invention relates to compounds of formula (I), wherein A is C(O) or CH(OH); R<1> is (1), (2), (3) or (4); R<2> is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R<5>C(O)-, R<5>C(S)-, R<5>SO2-, R<5>OC(O)-, R<5>R'NC(O)-, R<5>R'NC(S)-, adamantyl-C(O)-, or (5); R" is H, C1-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R"' is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; each R<3> independently is H, C2-6alkenyl, C2-6alkynyl, Het, Ar or C1-6alkyl optionally substituted by OR', SR', NR'2, R'NC(O)OR<5>, CO2R', CO2NR'2, N(C=NH)NH2, Het or Ar; R<4> is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R<5>C(O)-, R<5>C(S)-, R<5>SO2-, R<5>OC(O)-, R<5>R'NC(O)-, R<5>R'NC(S)-, R'HNCH(R')C(O)-, or R<5>OC(O)NR'CH(R')C(O)-; each R<5> independently is C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, Ar-C0-6alkoxy, Het-C0-6alkoxy, or C1-6alkyl optionally substituted by OR', SR', NR'2, R'NC(O)OR<5>, CO2R', CO2NR'2, N(C=NH)NH2, Het or Ar; R<6> is H, C1-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl and R<7> is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R<5>C(O)-, R<5>C(S)-, R<5>SO2-, R<5>OC(O)-, R<5>R'NC(O)-, R<5>R'NC(S)-, R'HNCH(R')C(O)-, or R<5>OC(O)NR'CH(R')C(O)-; or R<6> and R<7> are connected to form a pyrrolidine, a piperidine, or a morpholine ring; each R' independently is H, C1-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R* is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; Y is a single bond or O; each Z independently is CO or CH2; and n is 0, 1, or 2; or a pharmaceutically acceptable salt thereof, which are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor.
Patent SK-35395-A3 (SK)
Title: Process for control of goods load unit transferring from train to train and device for realization of this process
Inventor: ABEL BURKHARD
IPC: C09K3/10
Filed: 1993-09-25
Abstract: The sealants based on dispersions of polymers of ethylenically unsaturated monomers comprise the components     a) polymers of ethylenically unsaturated monomers, b) from 0.1 to 5% by weight of branched organopolysiloxanes, based on the total weight of the sealants,   c) dispersants,   d) fillers and e) water.  o
Patent SK-37298-A3 (SK)
Title: Cyclosporin-containing soft capsule preparations
Inventor: WOO JONG SOO
IPC: A61K/
Filed: 1997-06-19
Abstract: A composition (A) comprises: (a) cyclosporin (I) as active ingredient; (b) polyethylene glycol (PEG) and/or propylene carbonate (PC); (c) an oil component consisting of a mixture of an esterified compound of fatty acid and primary alcohol, and fatty acid monoglyceride; and (d) a surfactant (HLB value 8-17). Also claimed is the preparation of the composition comprising: (i) mixing (b), (c) and (d); (ii) adding (a) with stirring and heating to 60[deg]C; and optionally (iii) encapsulating the concentrate into a gelatin shell soft capsule containing PEG and propylene glycol as the plasticiser, followed by air cooling.
Patent SK-74799-A3 (SK)
Inventor: BORKO ANDREJ
IPC: H01H35/14
Filed: 1999-06-03
Abstract: Odpojovacic zariadenie, najmfl elektrickej sústavy dopravného
prostriedku od nap&jacieho zdroja, je tvorené nárazovým
spínacím prostriedkom (4), rozpfnacfm relé (S) a prepínacím
relé (3). Napájači zdroj (I)je napájaelm vedením
(2) pripojený na vstup (Sa) rozpfnacieho relé (5), ktorého
výstup (Sb) je pripojený na elektrickú napájaciu sústavu
dopravného prostriedku. Rozpínanie relé (S) je pripojené
cez prepínacie relé (3) na nárazový spínači prostriedok (4).
Patent CH-615566G-A3 (CH)
IPC: H03H9/02
Filed: 1977-02-24
Abstract: A piezoelectric resonator element having supporting lead members projecting in opposite directions therefrom is positioned in a tubular dielectric case having tubular metal cap members affixed at opposite ends thereof and extruding beyond the ends of the case. Inner end portions of the cap members are hermetically sealed to the case. Intermediate portions of the cap members beyond the ends of the case are compressed onto end portions of the lead members to secure the resonator element in position in the case and to make electrical contact between the lead members and the metal cap members. End portions of the cap members beyond the ends of the lead members are compressed to seal the case, the sealing being effected in a vacuum so as to evacuate the interior of the case. In order further to seal the case, the outer ends of the cap members may be welded or soldered.
Patent CZ-182192-A3 (CZ)
Title: Automatic feed balance
Inventor: DIEM WINFRIED
IPC: B28C7/04
Filed: 1992-06-15
Abstract: The present invention relates to a dosing balance having a measuring container (1) for bulk materials or liquids, at least the measuring container (1) being mounted on weighing elements (8). To make it possible to save space and, whilst ensuring a compact design, to dose any bulk materials or liquids exactly with such a balance, it is proposed, according to the invention, that a second measuring container (3) be arranged on the measuring container (1), and that there be provided for at least one of the two measuring containers (1, 3) a volume-measuring device (4) for determining the volume of the material contained in the container (1, 3). <IMAGE>
Patent CS-210791-A3 (CS)
Title: Process and apparatus for thread unwinding
Inventor: SARFATI ALBERTO GUSTAVO
IPC: B65H51/22
Filed: 1991-07-08
Abstract: To take off a yarn, ribbon or the like over the head of a wound bobbin, the yarn (4) is drawn alternately over one of the two end surfaces (1', 1'') of the bobbin (1). - A mounting (2) inhibits rotation by the bobbin (1). A take-off eyelet (3) is moved between the two take-off points (A,B) at the opposite ends of the mounting axis formed by the bobbin holder (2), where the bobbin (1) is held parallel to the axis. The bobbin holder (2) has a bed, with beadings in contact with the bobbin in the take-off direction, as a fabric which is laid to form the beadings, or it has a number of ribs shaped in the mounting bed parallel to each other curved round the axis as coiled wires. The bobbin mounting can also be formed by bristles in strips.
Patent CZ-214491-A3 (CZ)
Inventor: SIMUNEK LUBOMIR ING
IPC: B23K1/20
Filed: 1991-07-11
Abstract: Podle tohoto způsobu se úpravou konců tyče vinu tí kotvy
(1) v délce spoje tyče zbaví oxidů, za konzervujíse v lázni a
zabudují se do kotvy elektrického stroje (5). Potom se tyče
vinutí (1) ponorem do nízkoteplotní taveniny opatří na
konci zbaveném oxidů pájkou. Jako nízkoteplotní tavenina
se použije cíno-olovnatá pájka. Pak se tyče vinutí (1) ponoří
do aktivátoru, který je tvořen vodným roztokem na bázi
chloridu zineč natého nebo chloridu cínatého. Po vyjmutí z
ak tivátoru se provede odporové spojení tyčí vinutí kotvy
(1) s komutátorem (12). Úprava konců tyčí vinutí kotvy se
provede kartáčováním nebo otrys káváním a to buď před
rozdělením nekonečného profilu na jednotlivé délky tyčí vi-
‘i nutí kotvy nebo po jeho rozdělení.
Patent CZ-257091-A3 (CZ)
Inventor: PLACHY JIRI RNDR DRSC
IPC: C12P13/08
Filed: 1990-08-20
Abstract: Vysoký podíl buněk producenta threoninu - kmene Escherichia
coli 472 T-23 obsahujícího plazmidy s threoninovým
operonem a genem pro rezistenci vůči penicilinu - se zajistí
přídavkem 100 až 600 jednotek penicilinu G, při kterém je
tento minimálně degradován penicilinazou produkovanou
’ buňkami. Za těchto podmínek bylo dosaženo při konverzi
39 % sacharozy produkce 66 g/1 L-threoninu, což umožňuje
vyrábět tuto esenciální aminokyselinu pro účely medicínské
i krmivářské.
Patent CS-689887-A3 (CS)
Title: Novel psychostimulating substances of the phenylalkylamine derivativestype, process of their preparation and pharmaceuticals comprising them
Inventor: KNOLL JOZSEF DR
IPC: C07C211/27
Filed: 1987-09-25
Abstract: A method of treating a learning deficiency is disclosed wherein a patient in need of stimulating learning ability is treated with a therapeutically effective amount of a compound of the Formula (I) <IMAGE> (I)  wherein R1 is C1 to C8 straight or branched chain alkyl, C7 to C10 phenylalkyl, phenyl, or C3 to C8 cycloalkyl; and R2 is C1 to C8 straight or branched chain alkyl, unsubstituted or substituted by halogen, hydroxy, C1 to C4 alkoxy or by 1 or 2 phenyl groups; or is C3 to C8 cycloalkyl; with the proviso that R1 and R2 together contain at least 3 carbon atoms; or a pharmaceutically acceptable salt thereof.
Patent CZ-780587-A3 (CZ)
Title: Method of protecting a vessel for liquid metal
Inventor: BORSKI JAN
IPC: B22D41/02
Filed: 1987-10-30
Abstract: Method of protecting a vessel for liquid metal, mainly a steel pot in the form of a laying cylinder is based on creating step by step a local thickening of the walling so that one or more longitudinal rows of shaped units in the direction of the axis of the vessel are placed in stages and one or more cross-lateral shaped units in the direction perpendicular to the axis of the vessel are placed with grading and this grading is directed to the centre of the local thickening, in the direction inside the vessel above the level of the walling, the created wedged space is filled with a paste or semi-liquid fire refractory substance and then hardened by drying.<IMAGE>
Patent CZ-129394-A3 (CZ)
Title: Process and apparatus for producing fibrous cords
Inventor: TEUFEL EBERHARD DIPL CHEM
IPC: A24D3/04
Filed: 1994-05-26
Abstract: A description is given of a process for the simultaneous production of at least one fibre strand, at least one fibre strip being drawn off a supply (7), the at least one drawn-off fibre strip being fed for treatment, in the case of which the fibre strip is, inter alia, stretched and puffed up, the at least one treated fibre strip being brought together, in a formatting device (3), to form a fibre strand or filter strands (27.1, 27.2) which are provided with a sheathing material (23) in order to form one or more continuous, sheathed fibre strands, in particular filter strands (27.1, 27.2), the fibre strip or the fibre strips being subjected, at the beginning of the treatment, to a braking force in order to adjust the quantity to be processed and/or other properties of the fibre strip or of the fibre strips, the braking force being automatically adjusted. A description is given of two apparatuses which are particularly suitable for carrying out this process. The invention permits a higher degree of productivity along with the same good quality of the fibre strands or filter strands produced. <IMAGE>
Patent CZ-170994-A3 (CZ)
Title: Process for preparing extreme pure buspiron and hydrochloride thereof
Inventor: MEZEI LIBOR DR
IPC: A61P25/20
Filed: 1994-07-14
Abstract: The invention relates to a process for the preparation of 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione {buspirone} of the formula <IMAGE> and of its hydrochlorides by hydrogenating 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]but-2'-ynyl}-8-azaspiro [4.5 ]decane-7,9-dione of the formula <IMAGE> in the presence of a palladium or Raney nickel catalyst in an organic solvent and optionally converting the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione into a hydrochloride, in which a solution of 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]but-2'-ynyl}-8-azaspiro [4.5 ]decane-7,9-dione of the formula II in an organic solvent whose concentration is at least 40% by weight is added to a suspension of the catalyst in an organic solvent, the catalyst is removed and   a) the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione base of the formula I is isolated and/or b) the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione base of the formula I is treated with hydrogen chloride at 15 to 40 DEG C in ethanol or isopropanol and the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione hydrochloride melting at 188 to 191 DEG C is isolated or c) the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione base of the formula I is treated at at most 70 DEG C with hydrogen chloride in ethyl acetate or isopropanol and the 8-{4'-[4''-(pyrimidin-2'''-yl)piperazin-1''-yl]butyl}-8-azaspiro[4.5]d ecan e-7,9-dione hydrochloride melting at 201 to 203 DEG C is isolated.
Patent CZ-209194-A3 (CZ)
Title: Non-woven textile with improved absorption
Inventor: SUEHR SUSAN LYNN
IPC: D04H1/70
Filed: 1994-08-30
Abstract: A non-woven fabric having improved absorbent characteristics. The fabric has three different fiber arrays which are interconnected to produce a unique fiber distribution in the fabric.
Patent CZ-211198-A3 (CZ)
Title: Method of increasing activity of solid material consisting of particles containing zeolite
Inventor: DAVIS ROBERT E
IPC: B01J38/60
Filed: 1996-12-20
Abstract: A process for increasing the activity of a zeolite-containing particulate solid containing contaminants which block the pores of the zeolite and adversely affect the activity thereof wherein the contaminated zeolitic material is slurried with a liquid containing an acid, detergent or surfactant, the slurry is agitated to liberate the pore-blocking contaminants from the zeolite pores so that they are suspended in the liquid, a portion of the liquid is withdrawn from the slurry and filtered to remove the suspended contaminants, the resulting liquid is returned to the slurry, and the treated zeolite-containing particulate solid is removed from the solution and recovered.
Patent CZ-224394-A3 (CZ)
Title: Two-belt press
Inventor: BLAUHUT WILFRIED DIPL-ING
IPC: B30B9/24
Filed: 1994-09-14
Abstract: Double-belt press for the continuous production of webs of material, the pressing belts being supported by means of supporting strips acted upon by fluid pressing agents. <IMAGE>
Patent CZ-227195-A3 (CZ)
Title: Sandwich material for producing sporting balls as well as waterproof and air permeable shoe uppers
Inventor: NABINGER UDO
IPC: B32B5/26
Filed: 1995-09-05
Abstract: The invented sandwich material for producing sporting balls, optionally also a waterproof and permeable shoe upper material consists of three layers, a first outside layer from artificial material and at the same time abrasion-resistant layer (1) that is coupled with an intermediate layer made of spinning fiber web and having in all directions uniform expansibility and defined tensile strength  and this intermediate layer (2) is then further coupled with a third inside layer (3) made of staple fiber web.
Patent CZ-265998-A3 (CZ)
Title: Azabicyclic esters of carbamic acid intended for use in therapy
Inventor: PACOR JOHN
IPC: A61K31/47
Filed: 1997-02-21
Abstract: A compound of formula (I) wherein: A is (II), (III), (IV) or (V); X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C-R4; R1 is hydrogen or methyl; R2 is hydrogen or fluoro; R3 is hydrogen, halogen, C1 to C3 alkyl, -OR5, -CN, -CONH2, -CO2R5, -NR5R6 or phenyl optionally substituted with one to three of the following substituents: halogen, C1 to C3 alkyl, -NO2, -CN, or -OCH3; R4 is hydrogen, halogen, C1 to C3 alkyl, -OR5, -CN, -CONH2, -CO2R5, -NR5R6 or phenyl optionally substituted with one to three of the following substituents: halogen, C1 to C3 alkyl, -NO2, -CN, or -OCH3; or R2 and R3 or R3 and R4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C1 to C3 alkyl, -NO2, -CN, or -OCH3; R5 and R6 are independently hydrogen or C1 to C3 alkyl; or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.
Patent CZ-300794-A3 (CZ)
Title: Control of a couple of sbr reactors operation
Inventor: TOPOL JAN ING
IPC: C02F3/12
Filed: 1994-12-02
Abstract: A method of cleaning waste water in a pair of reactors with interrupted activity where in the first reactor the speed at which it is filled with waste water is measured and on the basis of the measured values in the second reactor the individual phases of activation are shortened or prolonged so that after the first reactor is filled the second reactor is discharged and ready to be newly filled with waste water.
Patent CZ-306499-A3 (CZ)
Title: Chimeric, vial, infectious, weakened virus, use thereof and nucleic acid molecule for treating flaviral infections
Inventor: CHAMBERS THOMAS J
IPC: C12N15/33
Filed: 1998-03-02
Abstract: A chimeric live, infectious, attenuated virus, containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
Patent CZ-328295-A3 (CZ)
Title: Process of disposing waste in a pressure generator and apparatus for making the same
Inventor: ZDARSKY BOHUSLAV
IPC: B09B3/00
Filed: 1995-12-13
Abstract: The invented process of liquidating waste matters, particularly industrial waste in either liquid, paste or solid state in a gasification apparatus consisting of a gas generator and other devices for accumulating and transport of waste matters is characterized in that the waste matters are withdrawn from a closed storage tank (7), transported through a delivery piping (6) of a controlled volume valveless pump (8) into a flow of a coal charge (3) inlet in pressureless section of a complex of at least one pressure generator (1) before entering the coal inlet hole (2), whereby the proportioned amount of waste matters in the charge is at least 50 percent by weight and from this fraction up to 40 percent by weight are incombustible waste matters, and the amount of the coal component is at least 50 percent by weight. The waste matters are then further gasified inside the pressure generator (1) at simultaneous action of steam and oxygen, under pressure up to 4 MPa and temperature ranging from 40 to 1500 degC.
Patent CZ-339896-A3 (CZ)
Title: Injection nozzle for piston internal combustion engines with direct injection of fuel
Inventor: PEREWUSNYK JOSEF
IPC: F02M61/08
Filed: 1996-11-19
Abstract: In the inside area of the basic body (10) of the jet there is at least one small groove (3), preferably in the form of a spiral.<IMAGE>
Patent CZ-375898-A3 (CZ)
Title: Concretes with cement-water ration above 0.80 and with enhanced rheological properties
Inventor: PAVLICA JIRI
IPC: C04B24/34
Filed: 1998-11-19
Abstract: The proposed concretes of low strength classes with cement-water ratio above 0.80 and with enhanced rheological properties, further with fresh concrete consistence being soft to liquid contain an air-entraining agent in the form of an aqueous solution and in an amount of 0.10 to 0.40 kg per one cubic meter of concrete and water in volume amount less than in a reference concrete without the air-entraining agent, whereby the sum of air and water volumes is comparable with the sum of air and water volumes in the reference concrete.
Patent ES-8706933-A3 (ES)
Title: Control of carbon di:oxide and oxygen concns. in enclosed spaces
IPC: F25B15/10
Filed: 1986-02-07
Abstract: Method and apparatus for monitoring the concentrations of CO2/O2 of a gaseous mixture in a space, using successive processes of adsorption and regeneration. At the start of the regeneration process, at least a portion of the gaseous mixture which is then in contact with an adsorption material is stored in order to be used, at the end of the regeneration process, for washing the adsorption material. The stored gaseous material may be used, also, for maintaining an atmospheric pressure in said space.
Patent SK-126098-A3 (SK)
Title: Improved surgical mask with adhesive strip to improve breathing
Inventor: YAVITZ EDWARD Q
IPC: A62B23/02
Filed: 1997-03-14
Abstract: A surgical mask (10) for covering a nose and mouth of a person is disclosed. The mask (10) is designed to facilitate the flow of air through the nose. The mask includes a stiff, adhesive strip (26) which, when secured over the nose, opens the nasal passages to allow more air to flow therethrough. In addition, the stiff, adhesive strip (26) prevents exhaled air from escaping through the top (14) of the mask and condensing on the wearer's glasses or other surfaces.
Patent SK-148498-A3 (SK)
Title: Regulating metabolism by modifying the level of trehalose-6-phosphate
Inventor: GODDIJN OSCAR JOHANNES MARIA
IPC: C12N5/06
Filed: 1997-05-02
Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.
Patent SK-152997-A3 (SK)
Title: Vaccine composition containing polyribosylribitol phosphate and method for making same
Inventor: ARMINJON FRANCOIS
IPC: A61P31/04
Filed: 1996-05-24
Abstract: Vaccine composition containing at least one antigen created by high molecular weight capsular polysaccharide of the influenza Haemophilus influenza of the type b or polyribosylribitol phosph ate condensed to the tetanus toxoid as well as adjuvant on the ba se of aluminium consists of that the adjuvant on the base of alum inium has in its natural state or after adding the anion pH the p oint of zero charge lower than approximately 7.2. Disclosed is al so preparation method of such vaccine composition.
Patent SK-263492-A3 (SK)
Title: Method of separating enantiomers of 5-hetaryl-1,3,4- -thiadiazinones
Inventor: JONAS ROCHUS
IPC: C07D285/18
Filed: 1992-08-26
Abstract: The invention relates to a process for the resolution of enantiomers of 5-heteroaryl-1,3,4-thiadiazinones of formula I by the kinetic resolution of racemates, characterized in that racemic I is dissolved in an inert solvent or solvent mixture and acylated with a chiral acid chloride. The resulting mixture of diastereoisomers is reacted with an amine or alcohol, thereby achieving a complete resolution of one of the diastereoisomers and a very slight or partial resolution of the other diastereoisomer into the enantiomers on which they are based, the resolution products are then separated off and the remaining pure diastereoisomer is converted to the corresponding pure enantiomer by reaction with an amine or an alcohol.