baber/WOPTO huggingface dataset:
Patent CA-2205968-A1 (CA)
Title: Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
Inventor: LEE EDWARD R
IPC: C07C327/42
Filed: 1995-12-08
Abstract: Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules.  Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation.  Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
Patent CA-2207974-A1 (CA)
Title: Treatment of tumors by transduction with negative selective markers, application of interaction agents and subsequent radiation exposure
Inventor: KIM SAN HIE
IPC: A61K48/00
Filed: 1996-01-04
Abstract: A method of treating a tumor which comprises transducing tumor cells with a nucleic acid sequence encoding a negative selective marker (such as a viral thymidine kinase gene), and contacting the cells with an interaction agent (such as acyclovir, ganciclovir, or a halogenated pyrimidine). The cells then are exposed to radiation. Such method provides for increased killing of tumor cells as compared with gene therapy or radiation treatments alone.
Patent CA-2208116-A1 (CA)
Inventor: CONATSER ROGER
IPC: B05B12/00
Filed: 1995-12-13
Abstract: Un pistolet à pulvérisation sans air (10) comporte un ensemble soupape d'aspiration (62) à double ressort qui permet d'allonger la course de la soupape d'aspiration (62), ce qui augmente le débit du fluide à travers la soupape sans diminuer le temps de réponse de celle-ci ni les opérations d'amorçage du système. Un amortisseur contribue également à réduire la cavitation et la chute de pression dans le pistolet à peinture (10) et comprend un raccord généralement en forme de T (36) dans lequel une section (46) dudit raccord (36) est fermée et renferme un volume d'air emprisonné (52) pour amortir les forces d'accélération-décélération et les brusques pointes d'accélération transmises depuis la pompe (20) jusqu'au fluide pompé à travers le raccord (36).
Patent CA-2209699-A1 (CA)
Title: Semiconductor device
Inventor: KAI SEIJI
IPC: H01L21/338
Filed: 1997-07-07
Abstract: The present invention provides a semiconductor device that is able to have the same Vp in all FETs formed on one chip. A semiconductor device of the present invention comprises a semiconductor substrate having a first region and a second region on a main surface. A first field effect transistor is formed on the first region of the main surface.  This first field effect transistor has first gates arranged in rows and a first total gate width. The first gates respectively establish a first gate length and a first gate width. A second field effect transistor is formed on the second region of the main surface. This second field effect transistor has second gates arranged in rows and has a second total gate width smaller than the first total gate width. The second gates respectively establish a second gate length substantially the same as the first gate length and a second gate width substantially the same as the first gate width.
Patent CA-2210645-A1 (CA)
Inventor: TANAKA YASUHITO
IPC: F16H7/12
Filed: 1997-07-10
Abstract: A belt tensioner arranged so that a turnable tension pulley is allowed to oscillate at a fulcrum of a position eccentric  from  the  center  of  rotation  thereof,  wherein tension control means for oscillating the tension pulley so as to keep tension of a belt constant and damper means for damping vibrations and shocks transmitted from the belt are provided individually at the side of the tension pulley.          The  tension  control  means  and  the  damper means  may  be disposed so that they fit within the overall size of the tension  pulley  on  the  side  of  the  tension  pulley  by disposing them side by side so as to adjoin on the same plane.
Patent CA-2210858-A1 (CA)
Title: Knit foot protector having integral padding and method of knitting same
Inventor: THRONEBURG JAMES L
IPC: A41B11/02
Filed: 1997-07-18
Abstract: A foot protector for providing cushioning comfort and support to the foot of a wearer is described. The foot protector has a toe portion, a ball portion and an instep portion, and a pad positioned on the ball portion. The pad has an arcuate front edge, and the pad is positioned on the foot protector such that the arcuate front edge of the pad is located proximate the juncture of the toe portion and the ball portion, such that the transition from the padded region to the relatively less padded region is positioned below the toe joints, where it is not readily felt by the wearer. The padding can be formed during the knitting process, with the padding being formed by a plurality of terry loops.
Patent CA-2211584-A1 (CA)
Inventor: RIVALTO MICHAEL A
IPC: G06Q20/18
Filed: 1995-10-25
Abstract: An automated drive-up vending facility (10) and method utilizes a plurality of automatic transaction machines (12) located around the periphery of a storage building (14), whereby customers can drive their vehicles alongside the building, insert an account/debit card into a card reader (16), and make product selections via a touch screen display terminal (18). The products are stocked within building (14), and an automated picking/sorting subsystem (20) retrieves the selected products for deposit into a dispensing chute (22).  Selection and product information is provided at the display terminals (18) via an interactive menu driven program. Selection of products subject to sales restrictions automatically activates video conferencing equipment (26) so that a sales attendant can confirm customer authorization to purchase the selected product. Customer purchasing history is stored and analysed to improve a product's chances of promotional marketing influencing a customer's product selection prior to the completion of a vending transaction.
Patent CA-2213570-A1 (CA)
Title: Electronic carillon system utilizing interpolated fractional address dsp algorithm
Inventor: SCHWARTZ GREGORY L
IPC: G10H1/26
Filed: 1997-08-21
Abstract: A DSP-based electronic carillon system is disclosed.  The system comprises a digital signal processor (DSP), memory for storing program code for controlling the operation of the DSP in carrying out pre-programmed algorithms, and an output circuit for converting the output of the DSP into audible sound.  DSP algorithms are also disclosed.
Patent CA-2218392-A1 (CA)
Title: Method of electroplating a substrate, and products made thereby
Inventor: BROWN WILLIAM D
IPC: C25D5/18
Filed: 1996-04-08
Abstract: Disclosed is an electroplating method and products made therefrom, which in one embodiment includes using a current density J0, to form a conductive metal layer (30) having a surface roughness no greater than the surface roughness (20) of the underlying member (10). In another embodiment of electroplating a substrate surface having peaks and valleys, the method includes electroplating a conductive metal onto the peaks to cover the peaks with the conductive metal, and into the valleys to substantially fill the valleys with the conductive metal.
Patent CA-2219782-A1 (CA)
Title: Gastrostomy feeding ports with positively sealing entrance valves
Inventor: RUSSO RONALD D
IPC: A61M37/00
Filed: 1996-05-15
Abstract: Gastrostomy feeding ports are disclosed which remain positively sealed after repeated and extensive use. In one embodiment, a valve housing (20) defines an inner passageway (29) to provide fluid communication into a long term indwelling catheter and includes a rigid compression collar portion (21) which defines a valve member receiving cavity (22) within the inner passageway (29). A resilient valve member (10) is compressively inserted within the receiving cavity (22), and defines a valve slit (16) which is normally biased closed when the valve member is inserted in the cavity.  A right angle feeding adapter (60) is received through slit (16) to provide for enteral feeding, medication or pressure relief.  Additional embodiments are disclosed which provide for the direct conversion of an implanted PEG tube into a low profile feeding port, and which further provide for direct connection to a feeding tube adapter.
Patent CA-2220151-A1 (CA)
Title: Process temperature control of a fluidized bed reactor
Inventor: ELKINS THOMAS SHIELDS
IPC: C22B34/12
Filed: 1996-04-29
Abstract: Process for temperature control in a fluidized bed reactor for chlorinating titanium bearing material is disclosed by comparing a carbonyl sulfide concentration with a predetermined set range and manipulating the temperature until the carbonyl sulfide concentration is maintained within the predetermined set range.
Patent CA-2220785-A1 (CA)
Inventor: BELMAAZA ABDELLAH
IPC: C12Q1/68
Filed: 1997-12-02
Abstract: A method relying on synthetic oligonucleotides as ligand for the parallel positive and negative selection for identifying and isolating target molecules that are differentially expressed in a plurality of biological system. These ligands comprise a randomized sequence region flanked by defined and fixed 5' and 3' regions. This method comprises many repetitive steps of incubation of target molecules from two systems with a pool of ligands, followed by a separation and an amplification of the ligands that bind in one system, and do not bind in the other system. The steps are repeated as many times as required to find ligands that bind specifically to the target molecules from system A but do not bind to the target molecules from system B. This method may be used as a very sensitive diagnostic tool since the final pool of ligands can identify target molecules that are different between normal vs pathological systems.
Patent CA-2222774-A1 (CA)
Title: Apparatus for and method of evenly distributing an electrical load across a three-phase power distribution network
Inventor: YAIR DAVID
IPC: H02J3/26
Filed: 1996-05-17
Abstract: An apparatus for and method of evenly distributing an electrical load (BRANCH  CIRCUIT 1-5) across a three-phase power distribution network. The current in each incoming phase and in each branch circuit is measured by a plurality of current sensors (16-20 and 42-50). The output of the current sensors (16-20 and 42-50) are monitored by a processor (12). Associated with each branch circuit (BRANCH CIRCUIT 1-5) is a multi-pole switch (22-30) and a conventional circuit breaker (14).  Each switch (22-30) is able to connect its corresponding branch circuit (BRANCH CIRCUIT 1-5) to any incoming phase or to disconnect the branch circuit (BRANCH CIRCUIT 1-5) from all three phases. The processor (12) periodically monitors the current flowing through each incoming phase and based on branch circuit load conditions, reprograms the switches (22-30) to keep the branch circuit loads (BRANCH  CIRCUIT 1-5) evenly distributed across all three incoming phases. In another embodiment, a summing circuit (52) combines the current capacities of all three incoming phases into a single summed output. This output is subsequently rectified (54) and used to generate (56) a single phase AC voltage which feeds all branch circuits (BRANCH CIRCUIT 1-5) in the system.
Patent CA-2222956-A1 (CA)
Title: Force and torque converter
Inventor: AVERY HAL
IPC: G06F3/033
Filed: 1996-06-03
Abstract: An apparatus provides an electronic signal in response to at least one of an applied force and an applied torque. The apparatus includes a detection device that detects movement of a movable member relative to a base, and provides the electronic signal, by driving a plurality of first sensor components. The detection device includes a control circuit having a first output that provides a digital control signal, and a first input for receiving a comparison signal, and a second output that provides the detection signal according to the comparison signal; a digital-to-analog converter having an input coupled to the first output of the control circuit, and an output that provides the drive signal in response to the digital control signal; and a measuring circuit having a first input coupled to the output of the digital-to-analog converter, a second input that receives a result signal from a plurality of second sensor components co-acting with the plurality of first sensor components, and an output coupled to the first input of the control circuit that provides the comparison signal, the plurality of first sensor components and the plurality of second sensor components co-acting with the controlling mechanism. The detection device is constructed using a method of constructing a printed circuit board assembly which includes the steps of: (A) forming a series of grooves in first PCB material to produce a bending region thereon; (B) bonding second PCB material to the first PCB material to produce an intermediate assembly, the second PCB material having an electrically conductive layer on one side; and (C) bending the intermediate assembly into the printed circuit board assembly.
Patent CA-2223075-A1 (CA)
Inventor: MCDONNELL PETER COLON
IPC: C12N15/12
Filed: 1997-12-02
Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein CSBP.beta., to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
Patent CA-2223716-A1 (CA)
Inventor: WOHLSTADTER JACOB N
IPC: C12N15/87
Filed: 1996-06-06
Abstract: The invention is directed to a method for generating novel catalysts; particularly high turnover rate enzymes or biocatalysts. Functional catalytic units may be integrated into the germline composition of an animal in order to generate such novel catalysts.
Patent CA-2223722-A1 (CA)
Inventor: COTTERET JEAN
IPC: A61K8/40
Filed: 1997-12-22
Abstract: L'invention a pour objet une composition prête à l'emploi pour la teinture d'oxydation des fibres kératiniques, en particulier des fibres kératiniques huma ines telles que les cheveux, comprenant au moins une base d'oxydation choisie parmi les paraphénylènediamines et les bis-phénylalkylènediamines, en association avec au moins un coupleur choisi parmi des méta-phénylènediamines, au moins un colorant direct cationique sélectionné et au moins un agent oxydant, ainsi qu e le procédé de teinture mettant en oeuvre cette composition.
Patent CA-2224410-A1 (CA)
Inventor: BREARD FRANCIS HENRI
IPC: A61B17/58
Filed: 1997-04-24
Abstract: A system for surgically stabilising the backbone is disclosed. The system is useful for preventing slippage of the joining bars on the vertebral attachment means. For this purpose, the joining bars are provided at predetermined intervals with spherical bulges having a greater diameter than said bar, which is thus somewhat dumbbell-shaped and has a length adapted to the morphological features of the spine.
Patent CA-2224514-A1 (CA)
Title: Thermal gradient beveling of catheters
Inventor: FIELD J DOUGLAS
IPC: B29C33/02
Filed: 1997-12-11
Abstract: A process for forming a catheter tip is described wherein a mold having an internal surface complimentary to the desired external surface of the catheter tip is formed such that it has two temperature zones. A first higher temperature zone is positioned proximally of the catheter distal tip and a lower temperature zone is positioned distal to the higher temperature zone. A catheter to be tipped is placed upon a mandrel or needle and the mold is heated. Upon insertion of the catheter and mandrel into the mold. The catheter material softens and begins to flow within the mold.      The higher temperature portion supplies the heat necessary to soften the catheter material and it flow to the lower temperature zone wherein the lower temperature causes the catheter material to become more viscous or resolidify. Upon becoming more viscous, the catheter material, at the very tip, acts as a dam to prevent further flow of material thus eliminating flash from the mold end.
Patent CA-2227139-A1 (CA)
Inventor: DE PASCHOAL GLAUCIO ROBERTO
IPC: B62D55/04
Filed: 1998-03-30
Abstract: Before the Winter season comes, it is known that motorists get ready to face the hardships of driving on snow and ice equipping their vehicles with rugged snow or four seasons tires, also carrying chains, picks, shovels and other gadgets to help them out in a frustrating situation, and all that are often proven to be totally worthless specially on frozen hilly roads situation, not to mention that they couldn't prevent dangerous or even fatal skids, plus the cost and incoveniences of salting and sanding of the roads. This novel equipment increases the adherence of the vehicle to the ground a great deal, improving its smooth motion and maneuverability on unstable terrain.
Patent CA-2228218-A1 (CA)
Title: Multipurpose cart assembly
Inventor: AIMOLA GAETAN
IPC: B62B1/00
Filed: 1998-04-07
Abstract: A multi purpose frame structure which can be utilized by the outdoor enthusiast for many purposes such as for carrying objects, carrying disabled persons, acting as a table, acting as an observation tower perched in a tree, acting as a back pack, as a seat, and as a wheeled vehicle having a central frame member. The multipurpose frame includes a central frame member defining first and second opposed sides and first and second opposed ends. An axle is mounted to the frame so as to extend transversely between the first and second sides. A first sub-assembly is located at the first end of the central frame member. The first sub-assembly includes a yoke having one end thereof pivotably secured to the central frame member. A second sub-assembly is located at the second end of the central frame member.The second sub-assembly has one end thereof pivotably secured with respect to the central frame member.  When used for transporting one or more objects, the mufti purpose frame assembly may include a caster wheel which is mounted on the yoke. The one end of the yoke pivotably secured to the central frame member is preferably secured thereto at a point spaced inwardly from the first end of the central frame member. When utilized with the caster wheel, the yoke may be secured to the central frame member to prevent pivotable movement of the yoke.
Patent CA-2230601-A1 (CA)
Title: Process for purifying sewage
Inventor: INGERLE KURT
IPC: C02F3/12
Filed: 1996-08-13
Abstract: A process for purifying waste water by means of activated sludge in which the waste water to be purified is taken into an aeratable sludge basin (1) followed by a sedimentation basin (5) in which the sludge and clear water are separated, whereafter sludge is taken back to the sludge basin (1) and clear water is drawn off; an operating cycle takes place in the sedimentation basin (5) several times a day in which the sludge is again mixed with the water (agitation phase R) and the withdrawal phase (A) of the operating cycle is separated from the agitation phase (R) by an interval (presedimentation phase V).
Patent CA-2231069-A1 (CA)
Inventor: TRIFIRO FERRUCCIO
IPC: B01J37/03
Filed: 1996-09-27
Abstract: La présente invention concerne un procédé de préparation d'oxydes mixtes de vanadium, d'antimoine et de fer, ainsi que leur utilisation comme catalyseurs pour l'ammoxydation des alcanes. Le procédé de préparation d'un oxyde mixte défini précédemment, est caractérisé en ce que: des composés respectifs de vanadium, d'antimoine et de fer sont mis en solution dans au moins un alcool saturé ou dans l'eau; la solution alcoolique ou la solution aqueuse ainsi obtenue est mise en contact avec une solution aqueuse contenant un sel d'ammonium, afin de précipiter l'oxyde mixte; l'oxyde mixte obtenu est séparé  et calciné.
Patent CA-2235680-A1 (CA)
Title: Improvements relating to antimicrobial cleaning compositions
Inventor: RABONE KENNETH LESLIE
IPC: C11D3/48
Filed: 1996-11-05
Abstract: The invention provides a hygienic cleaning composition of pH < 6 or pH > 8 which comprises: a) 0.01-30 wt.% on product of an ethoxylated nonionic surfactant, other than an alkyl phenol derivative, said surfactant having an HLB of 10-14 (this is typically an ethoxylated alcohol having a chain length of C8-C14 and 4-10 ethoxy groups per molecule), and, b) 1-30 wt.% on product of a C1-C5 linear or branched alcohol (this is typically selected from the group comprising propan-2-ol, propanol, ethanol and mixtures thereof). It is believed that the use of 1-30 wt.% of a C1-C5 linear or branched alcohol as a biocidal activity improving additive for the selected nonionic surfactants greatly improves the biocidal properties of the compositions under the pH  conditions specified. The specification also provides a method of cleaning and disinfecting a hard surface which comprises the step of treating said surface with a cleaning composition as claimed.
Patent CA-2235779-A1 (CA)
Title: Storing system for compact discs
Inventor: STANGEBYE-HANSEN HENRIK
IPC: G11B33/04
Filed: 1996-10-23
Abstract: Storing system for compact discs, where at least one metal clip (1) made of sheet metal is adapted to be secured to the back of each compact disc box (2), each clip (1) having a flange gripping the underside of the box, the clip (1) extending around the back face and the front face of the box to a second flange extending into the box (2) between the box and the box cover (3), the clip (1) thereby being biased and clamped to the box by the flanges, the system further comprising a magnet bar (4) to which the compact disc box (2) easily may be secured by means of the metal clip (1).
Patent CA-2237481-A1 (CA)
Inventor: LUTHER JAMES P
IPC: G02B6/38
Filed: 1998-05-12
Abstract: An adapter is provided for operatively mating two optical fiber connectors of the type that are aligned relative to each other by guide pins. The adapter has two sleeve body halves that are joined together at a mating ends. A guide pin mount is captured between the two sleeve body halves that defines an opening to allow abutment of the two connectors therethrough. Two guide pins mounted on the guide pin mount parallel with the passageway defined through the sleeve and located so as to engage the guide pin holes on the connectors and align two connectors inserted into the adapter.
Patent CA-2237640-A1 (CA)
Inventor: GAUTHIER PIERRE
IPC: G01N21/89
Filed: 1997-08-08
Abstract: Apparatus and method for detecting surface defects on an article freely standing on a conveyer, which generate profile trace data corresponding to profile trace at a cross section of the article. A surface shape inspection unit comprising an optical ranging system using laser and camera is provided for obtaining the profile trace data through triangulation-based derivation techniques. Base reference curves are derived from regular portions of the profile trace data. Profile trace data are compared to defect threshold curves to recognize a defect induced departure of the trace data with respect to the base reference curve and to produce a defect output signal. The apparatus and method according to the invention are particulary useful for detecting roughness, cavities, wane, missing wood and altered wood on lumber pieces which are conveyed at high speed.