Patent SG-11201901642X-A (SG)
Title: Constitutively active cytokine receptors for cell therapy
Inventor: SHUM THOMAS C T
IPC: C07K14/00
Filed: 2017-08-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111 0 iivi HIM 3E1 0 01111 OM 1111110E111 EMI ill OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/038945 Al 01 March 2018 (01.03.2018) W I P0 I P C T (51) International Patent Classification: C07K 14/00 (2006.01) A61K 38/19 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/US2017/046588 claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) — 11 August 2017 (11.08.2017) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/380,021 26 August 2016 (26.08.2016) US (71) Applicant: BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza, Houston, TX 77030 (US). (72) Inventors: SHUM, Thomas C.T.; 1885 El Paseo Street, Apt. 411, Houston, TX 77054 (US). GOTTSCHALK, Stephen M.G.; 1908 Canterbury, Houston, TX 77030 (US). OMER, Bilal; 1300 Bomar Street, Houston, TX 77006 _ (US). ROONEY, Cliona M.; 4802 Willow Street, Bellaire, TX 77401 (US). — = Agent: SISTRUNK, Melissa L. et al.; Norton Rose Ful- (74) bright US LLP, 1301 McKinney, Suite 5100, Houston, TX = 77010-3095 (US). = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (81) = = = SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 kin ii- tz. M en (54) Title: CONSTITUTIVELY ACTIVE CYTOKINE RECEPTORS FOR CELL THERAPY ---- (57) : Embodiments of the disclosure include methods and compositions for enhancing expansion of immune cells for im- GC , 1 munotherapy. In particular embodiments, immune cells, such as T-cells, express a constitutively active cytokine receptor in which the C::::) transmembrane and endodomains are able to provide an activating signal separately from any input to the corresponding exodomain N to which they are operably linked. In specific embodiments, the transmembrane and endodomain from IL-7Ra is utilized with the e m \") exodomain of CD34.