Patent SG-11201804136S-A (SG)
Title: Inhibitors of cxcr2
Inventor: CHEN XI
IPC: A61K31/5377
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau irst0) (43) International Publication Date .... ...../ 26 May 2017(26.05.2017) WIPO I PCT II (10) WO International 1111111111111111111111111111111111111111111111111111111 2017/087610 Publication DID Number Al IIIIRIIIIIIIIIIIIIII (51) International Patent Classification: (72) Inventors: CHEN, Xi; 1198 Beech Street, E. Palo Alto, A61K 31/407 (2006.01) A61K 31/5377 (2006.01) CA 94303 (US). DRAGOLI, Dean, R.; 24645 Summerhill A61K 31/404 (2006.01) Avenue, Los Altos, CA 94024 (US). FAN, Junfa; 4292 (21) International Application Number: Wilkie Way, #H, Palo Alto, CA 94306 (US). KALISIAK, PCT/US2016/062427 Jaroslaw; 1031 Crestview Drive, Apt. 104, Mountian View, CA (US). LELETI, Manmohan, Reddy; 7269 (22) International Filing Date: Ventana Drive, San Jose, CA 95129 (US). MALA- 17 November 2016 (17.11.2016) THONG, Viengkham; 121988 San Luis Avenue, #3, (25) Filing Language: English Mountain View, CA 94043 (US). MCMAHON, Jeffrey; 15 Alta Mar Way, San Francisco, CA 94121 (US). (26) Publication Language: English TANKAKA, Hiroko; 600 Rainbow Drive, #148, Moun- tain View, CA 94041 (US). YANG, Ju; 966 Clara Drive, (30) Priority Data: Palo Alto, CA 94303 (US). YU, Chao; 555 E. Washington 62/257,529 19 November 2015 (19.11.2015) US Avenue, Apt. 1105, Sunnyvale, CA 94086 (US) ZHANG, (71) Applicant: CHEMOCENTRYX, INC. [US/US]; 850 Penglie; 1036 Jamaica Street, Foster City, CA 94404 (US). Maude Avenue, Mountain View, CA 94043 (US). [Continued on next page] (54) Title: INHIBITORS OF CXCR2 (57) : Compounds are provided as inhibitors of CXCR2, hav- FIGURE IA ing the structure (I). CXCR2 IC 50 (nM) 0 0 c N N. N ° +++ 0 CONHz . . 1.001 / O r_ n N g r t vro &I ° 1.002 Fy + O COSH ilk 1.003 0 0 N 0 ° ++ \ / 1.004 o F O N N- ry 0 0 + co2H al 1.005 7 l ' -- ` ' ,.. ,,, Es /O wur N N +++ I'l 1.006 N 0 0 / .4t formula (I) : R ab 0 0 11 R 5 a / 71 Rsa \ = R 36 IN R fib -._ N X H H Ge R 6 a 0 R 2 0 Ril R1 IN I'l 0 ei O WO 2017/087610 Al MIDEDIMOMOIDEIRMEMONIMMOMEMMIDEVOIMIE MALI, Venkat; 20800 Valley Green Drive, #427, Cuper- tino, CA 95014 (US). SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (74) (81) Agents: KEZER, William B. et al.; Mintz Levin Cohn (84) Ferris Glovsky and Popeo, P.C., One Financial Center, Boston, MA 02111 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, Published: MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, — NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, with international search report (Art. 21(3)) RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV,