baber/WOPTO huggingface dataset:
Patent DO-P2005000112-A (DO)
Title: N-(2-bencil)-2-fenilbutamidas como moduladores del receptor de androgeno
Inventor: WANG JIABING
Filed: 2005-06-07
Abstract: Los compuestos de formula estructural I son moduladores del receptor de andrógeno (RA) de un modo selectivo de tejido. Estos compuestos son útiles en la mejora del tono muscular debilitado y en el tratamiento de afecciones provocadas por deficiencia en andrógeno o que se pueden aliviar por administración de andrógeno, incluyendo osteoporosis, osteopenia, osteoporosis inducida por glucocorticoides, enfermedad periodontal, fractura ósea, daño óseo que sigue a cirugla reconstructiva del hueso, sarcopenia, fragilidad, piel envejecida, hipogonadismo masculino, sintomas posmenopausicos en mujeres, ateroesclerosis, hipercolesterolemia, hiperlipidemia, obesidad, anemia aplasica y otros trastomos hematopoyóticos, artritis inflamatoria y reparación de las articulaciones, consunción por VIH, cancer de próstata, hiperplasia prostatica benigna (BPH), adiposidad abdominal, sindrome metabólico, diabetes de tipo II, caquexia cancerosa, enfermedad de Alzheimer, distrofias musculares, disminución cognitiva, disfunción sexual, apnea del suefo, depresion, insuficiencia ovarica prematura y enfermedad autoinmune, solo o junto con otros agentes activos.
Patent DO-P2006000010-A (DO)
Title: Procedimiento para preparar eteres aromáticos
Inventor: GHARBAOUI TAWFIK
Filed: 2006-01-05
Abstract: La presente invención esta relacionada con procedimientos para preparar compuestos de éteres aromáticos que son moduladores del metabolismo de la glucosa y por lo tanto son útiles para tratar trastornos metabólicos tales como la diabetes y la obesidad
Patent DO-P2015000215-A (DO)
Title: Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen
Inventor: PIMONT-GARRO ANNE
IPC: C07D307/85
Filed: 2015-09-04
Abstract: TOSILATO ABEXINOSTATO DE LA FÓRMULA (II): Y LA FORMA I CRISTALINA DE ESTE CARACTERIZADO POR EL PATRÓN DE DIFRACCIÓN X EN POLVO DEL MISMO, EL ESPECTRO DE RAMAN DE ESTE, Y EL ESPECTRO DE NMR CP/MAS 13C EN ESTADO SÓLIDO.
Patent DO-P2022000008-A (DO)
Title: Derivados de n-metil, n-(6-(metoxi)piridazin-3-il) amina como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas
Inventor: Christian Andreas KUTTRUFF
IPC: C07D487/10
Filed: 2022-01-19
Abstract: La presente invención se refiere a derivados de N-metil, N-(6-(metoxi)piridazin-3-il) amina como moduladores de autotaxina (ATX) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas tales como, por ejemplo, enfermedad pulmonar idiopática (IFF) o esclerosis sistémica (SSc). La presente descripción divulga la preparación de compuestos de ejemplo (por ejemplo, páginas 57 a 75; ejemplos 1.1 a 5) así como también datos biológicos relevantes de estos (por ejemplo, páginas 15 a 21, tablas 1 a 9). Un compuesto de ejemplo es, por ejemplo, 1-(6-(4-(((6-((6-(trifluorometilo)piridin-3-il)metoxi)piridazin-3-il)amino)metil)fenil)-2,6-diazaespiro[3.3]heptan-2-il)etan-1-ona (ejemplo 1.1).
Patent EC-SP11011341-A (EC)
Title: Inhibidores de epoxicetona proteasa de tripéptidos cristalinos
Inventor: PHIASIVONGSA PASIT
IPC: A61K38/55
Filed: 2011-09-20
Abstract: La invención se refiere a compuestos ceto epóxido de tripéptidos cristalinos, a métodos para su preparación y a composiciones farmacéuticas relacionadas.
Patent GB-189708073-A (GB)
Title: An Improved Spring Hub for the Wheels of Bicycles and other Vehicles.
Inventor: GIBBS WILLIAM GEORGE
Filed: 1897-03-29
Granted: 1897-07-03
Abstract: 8073. Gibbs, W. G. March 29. Spring wheels; hubs; dust-excluders. - To the axle-box A are hinged a number of rods or plungers F, F which pass through cylinders G, G, mounted on trunnions in a pair of rings K, K. The spokes of the wheel are secured to these rings, which are tied together by stay-bolts L, L. Any movement of these rings with regard to the axlebox is resisted by springs in the cylinders G. To exclude dust the cylinders are enclosed in casings W, X, and the rings K, K are connected to the axle-box by flexible diaphragms Y.
Patent GB-189716375-A (GB)
Title: Improvements in Metallic Lathing.
Inventor: FORDYCE ALEXANDER ROBERTS
Filed: 1897-07-10
Granted: 1897-08-14
Abstract: 16,375. Fordyce, A. R. April 5. [date claimed under Sec. 103 of Patents &c. Act, A.D. 1883]. Plates for walls, partitions, ceilings, &c. Slits are cut in the flat portions or panels B of corrugated metal sheets, and the edges of the slits are turned outwards alternately on opposite sides to form flanges b<1>, b<2>, b<3> which interlock with the plaster. The flanges of each panel are of a reversed form, and break joint with the flanges of the adjacent panels.
Patent GB-189718955-A (GB)
Title: Improvements in Horse-shoes.
Inventor: BROOMHEAD ROBERT
Filed: 1897-08-17
Granted: 1898-08-17
Abstract: 18,955. Broomhead, R. Aug. 17. Special section; india-rubber. - T h e shoe C is made with a groove of dovetail section to contain a strip of rubber E which may nearly or entirely fit the groove.
Patent GB-189719588-A (GB)
Title: Improvements in Shuttle Guards for Looms.
Inventor: GRAYSON JOHN
Filed: 1897-08-25
Granted: 1897-10-23
Abstract: 19,588. Grayson, J. Aug. 25. Loom shuttle guards.-Relates to guards having cranked parts b by which they are pivoted. Near one of the cranks is secured a bracket c with a projection c', by which the guard is held in the operative position. In Fig. 1 the projection is shown with an incline c<2> and recess c<3>, while in Fig. 3 the projection is shown formed with a rounded face c<2>. In this latter case the guard can yield inwardly, preventing trapping of the fingers. A spring is provided to hold the crank in contact with the projection. A cord attached to the guard may be connected to the fork lever or other part so that the guard is placed in the inoperative position when the loom is stopped; or the cord may be connected with a treadle.
Patent GB-189805603-A (GB)
Title: Improvement in Purification Processes for Treating Sewage and other Liquids.
Inventor: DEERY JOHN JEROME
Filed: 1898-03-08
Granted: 1898-07-09
Abstract: 5603. Deery, J. J. March 8. Sewage filters; filter beds; filtering-media.-Relates to processes for purifying water and other liquids, especially sewage. The water or other liquid flows from sewers 2 into one of a pair of receiving-chambers or reservoirs 3, shown in vertical section in Fig. 2, which are worked alternately. From the sewers the sewage flows along an open trough 5, whence it overflows and runs through filtering-material 9, supported upon a wrought-iron screen 11, and covered by a removable screen 10, consisting of several sections. Spongy iron, slag, coke, charcoal, or similar material may be used as a filtering-medium, and the coke or charcoal may be used as fuel after it has been used several times. Each reservoir 3 has an air inlet passage 16, and air outlet 17 communicating with an annular flue surrounding a chimney which serves to carry off waste gases from the boiler furnace belonging to the plant ; above each filter bed 9 is an air inlet 19, and outlet 18, communicating with the annular flue. The partially-purified sewage is pumped through pipes 23 and pipes 25 to a set of filter beds shown in section in Fig. 8. The upper filter beds 46 are supported by girders 49, 48 and posts or pillars 44 ; the sand and broken stone, slag, pebbles, or other filtering-material rest upon a large number of small iron pipes 50. The filtering-material is supported at the sides by girders 51 or other supports, and there are series of these dividing the filter bed into separate smaller beds. A pipe 25 supplies the sewage to smaller pipes 55 leading into a number of open troughs 57, whence the sewage overflows to the filter beds. The sewage falls from the upper filter and passes through a lower filter 47, comprising a middle layer of coarse sand and upper and lower layers of broken stones &c. The purified sewage passes along longitudinal and transverse channels 69, 65 into a main drain 64 ; the channels 69, 65 are ventilated by means of vertical shafts 70, 67, which are provided with hoods. Between the two reservoirs 3 is an oven used for extracting grease from the filtering- material 9, Fig. 2, after the removal of the latter. The oven is provided with a steam coil for heating the material so as to melt the grease, which runs to the bottom of the oven through a wire netting or other screen resting upon the lower part of the coil and supporting the filtering-material.
Patent GB-189807615-A (GB)
Title: Improvements in Sliding Trivets.
Inventor: HOLMES DAVID
Filed: 1898-03-30
Granted: 1898-06-18
Abstract: 7615. Holmes, D. March 30. Trivets.-Fig. 2 shows a form of sliding trivet in which ears cut out at E are turned down and perforated so as to slide on the rod A, the ends of which are then riveted to the hanger H. In a modification, seen in Fig 7, the lugs E are slotted, the plate B being capable of being tilted by using different slots at the rear and front.
Patent GB-189808369-A (GB)
Title: Improvements in Alcohol or Spirit Lamps.
Inventor: OTTEN GERRIT CORNELIS
Filed: 1898-04-07
Granted: 1898-06-18
Abstract: 8369. Otten, G. C., and Henneman, K. F. April 7. Vapour lamps.-Vapour burner intended more e particularly for drying or roasting coffee &c. The reservoir A contains cotton waste G and asbestos waste H, separated by a gauze partition and pressed upwards against the gauze I by a spring L. The burner tube B passes through the reservoir, the heat generating vapour c o ntrolled by the cock D and issuing at M. Air is admitted in required amount at F, and the cavity b serves as a vaporizing - cup w h e n starting the burner. Cotton wicks may pass from the cotton to the asbestos waste. The spirit is admitted to the reservoir through an inlet not seen in Fig. 2.
Patent GB-189809061-A (GB)
Title: Improvements in Cigarette-making Machines.
Inventor: EATON JOHN ORIN
Filed: 1898-04-19
Granted: 1898-06-18
Abstract: 9061. Eaton, J. O. April 19. Cigarette-making machines.-Relates to mechanism for producing a crimped non-pasted seam in continuous-cigarette machines, the crimping being effected entirely by external means without the use of a crimper or mandrel within the paper tube. The paper wrapper is folded about the continuous filler-rod by passage through a guide C which is gradually curved into the section seen in Fig. 16. The higher of the upstanding e d g e s of the wrapper is now folded over at right-angles by means of the edges of the wheels E, F, Fig. 3, which together with the grooved or channelled block A form a passage of circular section. The edge thus bent over is turned down by the bevelled wheel H, and guide-plates J, I, Fig. 9, press the edges into a vertical seam. The cigarette rod now passes between a second pair of wheels K, L, Fig. 10, the edges of which doubly fold the seam into the horizontal position. The crimping of the seam is now effected as shown in Fig. 12, the angular and corrugated edges of a pair of inclined wheels R, S serving to support the seam while it is crimped by the pressure of the inclined crimping-wheels T, U. The cigarette is finally pressed between a pair of grooved wheels before passing on to the cutting-mechanism. The crimping-wheels are supported in such a way as to be adjustable both laterally, as to inclination, and as to the pressure exerted upon the seam.
Patent GB-189818919-A (GB)
Title: Improvements in Brakes.
Inventor: SAUVAGE WILLIAM HENRY
Filed: 1898-09-05
Granted: 1899-04-08
Abstract: 18,919. Sauvage, W. H., Wood, H. N., and Dearing, D. M. Sept. 5. Brakes.-The invention is shown and described as applied to railway vehicles, but it is stated to be applicable to all vehicles. Fig. 1 shows a side view of the brake shoe and operating-shaft. The brake shoe 6 is bolted at its ends to a wedge 5, which is formed with teeth to engage with the pinion 8, both sets of teeth being formed with a central ridge which acts as a sliding surface for the opposite ridge. When the shaft 9 is rotated, the brake shoe is raised or lowered, but in either case it is pressed against the wheel and is then automatically drawn by the friction of the wheel into closer contact.
Patent GB-189819818-A (GB)
Title: Improvements in Locking Bolts and Nuts and the like.
Inventor: MALONEY BERNARD JOSEPH
Filed: 1898-09-19
Granted: 1899-09-19
Abstract: 19,818. Maloney, B. J. Sept. 19. Locking nuts.-The nut B is locked on a bolt for a plummer block &c.or on the screwed end of a wheel axle F by a collar C which slides without turning on the nut B and has teeth to engage with similar teeth on a collar A, which has a square or D-shaped &c opening to fit on to the axle F. The nut B bears against the collar A, and the two collars are normally forced together by a spring H or screw. Keyed wheels may thus be kept on their shafts. A journal may be formed by a tube D fitting on the squared &c. part K of the axle F and closed by a nut E. The tube D may have studs &c. fitting into holes &c. in the wheel or the like.
Patent GB-189819864-A (GB)
Title: Improvements in Gridirons for Cooking Purposes.
Inventor: SHEPHERD TERESA EMILIE
Filed: 1898-09-19
Granted: 1898-12-03
Abstract: 19,864. Shepherd, T. E. Sept. 19. Grilling-apparatus.-Consists of a frame having sheet-metal sides a secured to wires band c and provided with ledges or their equivalent a', a<1>, a'. The gridiron, which is provided with a handle d<1>, may be placed on one or other of the ledges a, to regulate its distance from the fire.
Patent GB-189820480-A (GB)
Title: An Improved Hose Fastener.
Inventor: CRAIG CHARLES
Filed: 1898-09-28
Granted: 1899-03-25
Abstract: 20,480. Craig, C. Sept. 28. Hose, connecting to pipe connections ; clip joints. - Relates to a clip joint for fastening hose pipes to pipe e connections. A pipe b has formed on it a ring a, over which fits an india-rubber pipe f. A wire clip c is bent round as,shown, and the ends d are twisted together by means of a slotted key.
Patent GB-189901894-A (GB)
Title: Improvements in Steam Generators for Road and other Vehicles.
Inventor: TOWARD THOMAS
Filed: 1899-01-27
Granted: 1899-11-25
Abstract: 1894. Toward, T., Toward, W., and Meek, J. Jan. 27. Water-tube boilers for motor road vehicles &c. In the arrangement shown in Fig. 2, a number of water tubes T and a cylindrical steam and water drum B connect the two flat water chambers S, S, each of which consists of a dished plate bolted to the tube-plate. Fig. 4 shows a modification in which one water chamber is dispensed with. In this case the tubes T project through a perforated casing plate X sufficiently to form a cool space in each tube for the collection of deposit, the ends of the tubes being fitted with screw plugs. The top and sides are enclosed by a light casing, and the furnace gases, after playing among the tubes T, pass round the drum B on their way to the chimney E. Instead of being inclined as shown, the tubes and drum may be horizontal, and the water chambers may be placed much further apart.
Patent GB-189902360-A (GB)
Title: Manufacture of Black Disazo-colouring Matters.
Filed: 1899-02-02
Granted: 1899-11-18
Abstract: 2360. Abel, C. D., [Actiengesellschaft fiir Anilin Fabrikation]. Feb. 2. Dyes, artificial.-Relates to the process of producing black disazo dyes described in Specification No. 24,527, A.D. 1897, and consists in combining the diazo compounds of certain substituted p-amidodiphenylamine sulphonic acids or the diazo compounds of p-amidophenyl-#-naphthylamine sulphonic acids with alpha-naphthylamine, re-diazotizing the intermediate products thus formed, and combining the diazoazo compounds thus obtained with a naphthol or a naphthol sulphonic acid. The compounds employed as first components are (1) the sulphonic acids obtained by the action of p-nitrochlorobenzene-o-sulphonic acid on one of the following amido products, viz.:-o-, p-, or m-chloraniline, acetyl-p-phenylenediamine, or m-amidop-cresol ether, and then reducing the nitro products thus formed ; and (2) the sulphonic acids of p-amido-phenyl-#-naphthylamine obtained by first reacting with p-nitrochlorobenzene sulphonic acid upon #-naphthylamine, or its sulphonic acids, and then reducing the nitro condensation products thus obtained.
Patent GB-189906309-A (GB)
Title: An Improved Device for Hanging up Wineglasses.
Inventor: DICKSON HAUGHTON
Filed: 1899-03-23
Granted: 1899-06-10
Abstract: 6309. Dickson, H. March 23. Hooks; eyes, screw.-Wine glasses and similar glasses with stems are suspended from a wall or beneath a shelf &c. by a ring A with an opening D or by a spiral A'. The ring or the spiral is made of wood, metal, stoneware, &c., and is fixed by a screwed stem C or by a spiked stem which lies in the plane of the ring or spiral as shown in Figs. 2 and 4, or at right-angles thereto as shown in Fig. 3, according as the stem C is fixed to a vertical or a horizontal surface. A group of these rings or spirals may be attached to a single fixing spike or screw.
Patent GB-189912752-A (GB)
Title: Improvements in Bridges for Musical Stringed Instruments.
Inventor: COOPER ARTHUR DAILEY
Filed: 1899-06-19
Granted: 1899-07-22
Abstract: 12,752. Cooper, A. D. June 19. Violins and like instruments. - The invention relates to bridges, and consists in making them with openings C of the same shape as the sound-holes of a violin.
Patent GB-189918173-A (GB)
Title: Improvements in Telephonic Systems and in Apparatus therefor.
Inventor: BYNG MAX
Filed: 1899-09-08
Granted: 1899-11-04
Abstract: 18,173. Byng, M., and Bell, F. G. Sept. 8. Telephone systems.-Relates to that form of telephone system by which a number of subscribers are connected to a central station by common call and return wires together with separate conversation wires for each subscriber. The common return wire may be omitted when it is desired that the separate sub-stations shall only communicate with the central station. The central station is arranged either as described in Specification No. 16,877, A.D. 1898, or has the subscriber's connections arranged under a rotating switch arm, and has a separate calling-key connected in circuit with the said switch arm. The subscriber's conversation lines are also branched to a plug board, when it is desired that the central station shall be able to connect up any two substations. The sub-stations have an extra switch for connecting to their calling or conversation lines respectively, or, as shown in Fig. 5, the two plugs.P, P' can throw over the T lever M so as to connect to either of the lines u, u<1>. Fig. 5 also illustrates the circuits of the bell magnet S, induction coil I, and telephonic instruments R, T.
Patent GB-189920245-A (GB)
Title: Improvements in connection with Tramcars, Motor Cars, and like Vehicles for Removing Persons and Animals from the Path of and Preventing them being Run Over by such Vehicles.
Inventor: EMETT BRYAN THOMSON
Filed: 1899-10-09
Granted: 1899-11-18
Abstract: 20,245. Emett, B. T. Oct. 9. Obstruction - removers.-The fender is shown extended in Fig. 3, and folded up in Fig. 4. It consists of three lattice - work sections. The upper section 1<b> is carried by the links 10 pivoted from the supports 4. The middle section 2<b> is carried by the rods 6 from the supports 4, and is provided at its lower end with spring buffers 7. The lower section 3<b> is pivoted to the middle section, and carries rubber rollers 14. The whole three sections are housed in the manner shown.
Patent GB-189921161-A (GB)
Title: Improvements in Match Holders.
Inventor: HANUS MARCEL
Filed: 1899-10-23
Granted: 1899-12-02
Abstract: 21,161. Hanus, M. Oct. 23. Match receptacles. -A match holder b is fitted within a stand a provided with a cap c formed with an aperture o which receives a perforated indiarubber disc p. The cap c may be secured to the stand by means of a screw joint, or by means of a circumferential rib e which enters a corresponding groove f in the cap. A pivoted lever l is connected to a sliding rod j, which passes through an aperture n in the holder b and serves to push one match at a time through the aperture in the disc p. The rod j is guided by means of hollow rods g supported by springs h which cause the holder to be shaken during the working of the ejecting-mechanism. In a modification, the holder is fixed and the match-ejecting rod is actuated by means of a lever and coiled spring.
Patent GB-189921572-A (GB)
Title: The Manufacture and Production of Products suitable for use in the Preparation of Colouring Matters.
Inventor: JOHNSON JAMES YATE
Filed: 1899-10-28
Granted: 1900-09-01
Abstract: 21,572. Johnson, J. Y., [Badische Anilin & Soda Fabrik]. Oct. 28. Chlor- and brom-diamido- and -dialphylidoanthraquinone, which are insoluble products suitable for use in the preparation of colouring-matters, are produced by acting upon diamidoanthr aquinone sulphonic acids and dialphylidoanthraquinone sulphonic acids in aqueous solution with chlorine or bromine at the ordinary temperature. Instead of the isolated sulphonic acids, the sulphonation melts obtained by acting upon diamidoanthraquinones or dialphylidoanthraquinones with sulphuric acid or fuming sulphuric acid may be employed. Examples are given in which brom- 1 : 4<1>-diamidoanthraquinone, brom derivatives of 1 : 1'- and 1 : 3-diamidoanthraquinones a chlor derivative of 1 : 4<1>- diamidoanthraquinone, a brom derivative of 1 : 4'-dianilidoanthraquinone, chlor- 1 : 4<1>- ditoluidoanthraquinone and chlor - 1 : 4<1>- dianilidoanthraquinone are produced by these processes.
Patent GB-189924970-A (GB)
Title: Improvements in Electric Hair-brushes.
Inventor: SCHMUTZ KARL ROBERT
Filed: 1899-12-16
Granted: 1900-02-03
Abstract: 24,970. Schmutz, K. R., [trading as Robert, K.]. Dec. 16. Electric brushes.-In a hair brush, the wire bristles b, c, connected respectively to the different poles of the battery, are separated by hog's bristles b or bristles of any other insulating-material. Rows of similar insulating-bristles may be arranged outside the bristles b.
Patent GB-190005658-A (GB)
Title: Improvements in Billiard-cues.
Inventor: BRAUERS JEAN
Filed: 1900-03-26
Granted: 1900-04-28
Abstract: 5658. Brauers, J. March 26. Billiards, cues for. Billiard cues are made in two parts, which are separated by an elastic disc. The two parts 1, 2 are recessed at their ends to receive pieces 5, 6 of horn or other material, between which a disc 9 of soft rubber &c. is placed. A central bolt 10, with square head 12 and nuts 13, 15, connects the parts but allows the disc to be compressed. Sleeves 17, 18 are fixed to the parts 1, 2 as shown, to cover the joints. A pin 20 engagas a slot in the sleeve 18, to prevent rotation of the parts.
Patent GB-190010352-A (GB)
Title: Improvements in Cider, Wine & other Screw Presses.
Inventor: BARRETT FRANCIS JOHN
Filed: 1900-06-06
Granted: 1901-06-06
Abstract: 10,352. Barrett, F. J. June 6. Cider; wine.-Relates to cider, wine, and other screw-presses. The shaft c, of square or other suitable section, slides through but rotates with the flanged pulley d, and carries a gear-wheel which drives the wheel b on the horizontal shaft b. The gear-wheels o drive the screw boxes g on the side screws l. An iron tray k, with an outlet, is fixed on the sill p of the press, fitted with wood q and concrete bottom r.
Patent GB-190011005-A (GB)
Title: Improvements in and relating to Elastic Tyres for the Wheels of Vehicles.
Inventor: FIRESTONE HARVEY SAMUEL
Filed: 1900-06-16
Granted: 1900-09-15
Abstract: 11,005. Firestone, H. S. Nov. 20, A.D. 1899, [date applied for under Sec. 103 of Patents &c. Act, A.D. 1883]. Tyres, elastic other than pneum a t i c ; felloes or rims.-The channel rim 1, having outwardly-inclined side walls 4, receives a rubber tyre 2, which is attached by an embedded metallic retaining- band 8. The crosssection of the band is arch-shaped, with beaded edges 9, and the overlapping ends of the band are secured together by brazing the tongue 10, Fig. 5, to the edges of the cut-away part, and by passmg a rivet through the holes 13.