baber/WOPTO huggingface dataset:
Patent CA-2450949-A1 (CA)
Title: Methods and compositions for polyene antibiotics with reduced toxicity
Inventor: KWON GLEN S
IPC: A61K47/34
Filed: 2002-06-28
Abstract: Provided are methods and compositions for reducing the toxicity of certain hydrophobic therapeutic agents, especially polyene antibiotics, in particular, Amphotericin B (AmB), and therapeutics such as paclitaxel, tamoxifen, an acylated prodrug or an acylated cis-platin, by incorporating these agents within micelles comprising an amphiphilic block-forming copolymer. Where the polyene is amphotericin B, desirably the spacer is an alkyl molecule of about 2 to about 8 carbon atoms, desirably 6 carbon atoms, and the core is an N-alkyl molecule of about 8 to about 28 carbon atoms, desirably 12 to 22 carbon atoms, advantageously, 12 to 18 carbon atoms, and as specifically embodied, 18 carbon atoms (stearate moiety). For the formulation of a larger polyene, the spacer and core are proportionately larger than those for amphotericin B. As specifically exemplified herein, the polymer backbone is a PEO of about 270 units with about 10-30 core-forming PLAA subunits, and advantageously about 14-24. Desirably the stearate moiety has a substitution level on the copolymer from about 35 percent to about 70 percent.
Patent CA-2451782-A1 (CA)
Title: Method and device for suppressing electromagnetic background radiation in an image
Inventor: KIRSCHNER HOLGER
IPC: G01S17/89
Filed: 2002-06-07
Abstract: The invention relates to a method and a corresponding device with which images (A, B) for the same sensing range, however in different wavelength ranges (P, N1, N2), are recorded at the same time or about the same time, and with which a signal to be detected is recorded for an image (A) serving as a P-image, and the wavelength of the signal is suppressed for an image (B) serving as an N-image. The intensity of the background in the P-image (A) is deduced from the N-image (B) while using a model for the interfering radiation or background radiation (2). The position of the signal to be detected is determined by comparing the image contents of the P-image (A) and the background image (C) derived from the N-image (B).
Patent CA-2451945-A1 (CA)
Inventor: MAYER YARON
IPC: H04N5/76
Filed: 2003-12-12
Abstract: One of the most frustrating things when recording for example songs from the radio is that many times by the time the user decides that he/she would like to record for example some song, the beginning of the song is already lost. Or the user might zap between radio stations and tune into the station after the song has already started or for example after the beginning of an interesting conversation or message or News item and is frustrated that he missed the beginning of it.  Similarly, for example while zapping through cable TV stations, a user might find for example a fascinating scientific program or a fascinating report and regret that he/she had not seen or recorded it from the start for later reference. The idea of retroactive recording and/or replay has existed already since 1990 and there are a number of patents about it, but they do not deal with the problem of enabling retroactive recording and/or replay also when the user is zapping between channels for example on Radio or on TV. The present invention describes an improved system and method for automatic time-shifted retroactive recording or replay, that applies retroactive recording and/or replay also to a situation of switching between channels. Additional improvements and possible implementations are also shown.
Patent CA-2452956-A1 (CA)
Inventor: O'DWYER JAMES MICHAEL
IPC: F41A9/35
Filed: 2002-06-19
Abstract: A barrel assembly (14) for insertion into a parent barrel (13) of a gun (10) wherein said barrel assembly has a plurality of projectiles (16) axially disposed within at least one barrel (15a) of said barrel assembly and associated with discrete selectively ignitable propellant charges for propelling the projectiles from said at least one barrel wherein said barrel assembly (14) includes a parent barrel engaging means. The barrel is suitabl y provided in a removable rear barrel section (15a) having engagement means (1 7, 18) for operatively aligning the rear barrel section with a forward barrel extension. Spare rear barrel sections (15b, 15c) may be stored in a stock (1 1) of the gun (10) and automatically fed into alignment upon exhaustion of the projectiles (16) in the barrel.
Patent CA-2454598-A1 (CA)
Title: Systeme de coussin gonflable a structure de diffuseur
Inventor: TOKUNAGA SHINYA
IPC: B60R21/262
Filed: 2002-07-22
Abstract: L'invention concerne un système de coussin gonflable dans lequel un coussin gonflable stocké à l'état plié dans un véhicule est conçu pour être gonflé au moyen de gaz distribué à partir d'un dispositif de gonflage, via un diffuseur, de manière à protéger un occupant du véhicule. Dans le système de coussin gonflable, le diffuseur est disposé sur un côté du dispositif de gonflage, de manière que le diffuseur et le dispositif de gonflage soient sensiblement alignés l'un avec l'autre et le diffuseur comprend une partie d'alimentation de gaz exposée à un orifice d'entrée de gaz dans une partie généralement médiane du coussin gonflable, prise en considération dans le sens longitudinal.
Patent CA-2455505-A1 (CA)
Title: Staging mechanism for toy vehicle playset
Inventor: SHELTMAN DAVID A
IPC: A63H18/02
Filed: 2002-09-19
Abstract: A continuous loop toy vehicle track set (10) supports a booster (30) and a plurality of toy vehicles (40, 50). The track set (11) is formed of spaced apart track rails (60, 62) forming a gap therebetween. The toy vehicles (40, 50) are open wheeled and able to roll upon the track rails (60, 62) in either a right side up or inverted configuration. In the inverted configuration, the top surface (56) of the toy vehicle (56) is able to extend into the gap between the track rails (60, 62). A staging lane (20) facilitates introduction of additional toy vehicles to the track set (11).
Patent CA-2455559-A1 (CA)
Inventor: ABRAMS MICHAEL J
IPC: A61K/
Filed: 2002-07-30
Abstract: L'invention concerne des méthodes permettant d'accroître les nombres de cellules souches et embryonnaires chez des animaux, à l'aide de composés qui se lient au récepteur de chimiokine CXCR4. Des modes de réalisation préférés de tels composés concernent la formule Z-lieur-Z' (1) ou un sel correspondant acceptable pharmaceutiquement, Z représentant un polyamine cyclique contenant entre 9 et 32 éléments d'anneau dont 3 à 8 éléments sont des atomes d'azote séparés les uns des autres par au moins 2 atomes de carbone, et ledit hétérocycle pouvant contenir des hétéroatomes supplémentaires autres que l'azote et/ou pouvant fusionner avec un système d'anneau supplémentaire ou Z étant de formule (a). Dans cette dernière formule, A comprend un système d'anneau fusionné monocyclique ou bicyclique contenant au moins un N et B représente l'hydrogène ou un groupe fonctionnel comprenant de 1 à 20 atomes. Z' peut être représenté sous une forme définie par Z susmentionné ou peut avoir la formule -N(R)-(CR¿2?)¿n?-X, dans laquelle X représente indépendamment H ou un alkyle (1-6C) cyclique ou ramifié, droit, n est égal à 1 ou 2, et X est un anneau aromatique, comprenant des anneaux hétéroaromatiques ou un mercaptan. Un "lieur" représente un lien, un alkylène (1-6C) ou peut renfermer des atomes d'oxygène, d'aryle fusionné, d'aryle compris dans une chaîne d'alkylène ou peut contenir des groupes cétoniques ou des atomes d'azote ou de soufre.
Patent CA-2458681-A1 (CA)
Inventor: BRAUN HANS-JUERGEN
IPC: C07D333/22
Filed: 2002-04-24
Abstract: L'invention concerne des dérivés de 3-aminophénol représentés par la formule (I), dans laquelle R est un composé aromatique hétérocyclique à 5 chaînons représenté par la formule (Ia), ou leurs sels solubles dans l'eau physiologiquement tolérables. L'invention concerne également des colorants à base d'une combinaison révélateur-copulateur caractérisés en ce qu'ils contiennent lesdits composés.
Patent CA-2459138-A1 (CA)
Title: Modified human growth hormone
Inventor: CARTER GRAHAM
IPC: C12Q1/04
Filed: 2002-08-30
Abstract: The invention relates to the modification of human growth hormone (high) to result in human growth hormone proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in-vivo. The invention relates, furthermore, to T-cell epitome sequences deriving from high, which are immunogenic.
Patent CA-2460317-A1 (CA)
Title: Quinone reductase 2 and aldehyde dehydrogenase as therapeutic targets
Inventor: HAYSTEAD TIMOTHY A
IPC: C12Q1/26
Filed: 2002-09-16
Abstract: The present invention relates, in general, to quinone reductase 2 (QR2) and aldehyde dehydrogenase (ALDH), and, in particular, to methods of screening compounds for their ability to modulate the activity of QR2 and/or ALDH and thereby to function as anti-malarial, anti-arthritic and/or anti-lupus agents.  The invention further relates to the use of compounds that inhibit ALDH in the production of stem cells en masse.
Patent CA-2460470-A1 (CA)
Inventor: SHINOHARA TOSHINARI
IPC: B60L50/16
Filed: 2002-09-10
Abstract: A motor controller of a deceleration idling-cylinder engine vehicle idling a part of cylinders when the vehicle decelerates and driving a motor when an operation is moved from a deceleration idling-cylinder operation to a normal operation, comprising an idling-cylinder state discrimination means (S202) f or judging whether the engine is in the state of idling or not, an idling- cylinder execution means for executing the idling-cylinder operation of the engine, an idling-cylinder operation detection means (S201) for detecting th e operation or non-operation of the idling-cylinder execution means, and start torque set means (S201 to S204) for setting an engine start torque by the motor, wherein the start torque set means sets the motor start torque lower than a normal start torque when the engine is detected by the idling-cylinde r state discriminating means to be in the idling-cylinder state and judged by the idling-cylinder operation detection means that the engine tries to retur n to the normal operation, whereby the output of the motor can be optimally se t when the operation is moved from the deceleration idling-cylinder operation to the normal operation to smoothen the operation and improve a fuel consumptio n.
Patent CA-2462145-A1 (CA)
Inventor: KRAFT HARALD
IPC: C02F11/12
Filed: 2002-10-01
Abstract: The invention relates to a method for purifying wastewaters, particularly wastewaters produced in the paper industry, involving the following steps: a) aerobic clarification of the wastewater using activated sludge in an activation stage; b) carrying out, in a secondary settling tank, a subsequent clarification of a portion of the wastewater/activated sludge mixture leaving the activation stage; c) desiccating, in a desiccation unit, another portion of the wastewater/activated sludge mixture leaving the activation stage; d) returning at least a portion of the activated sludge removed in steps b) and c) into the activated sludge tank.
Patent CA-2462720-A1 (CA)
Inventor: HADERLEIN GERD
IPC: B01J31/18
Filed: 2002-10-04
Abstract: L'invention concerne des phosphinites I de formules (1) ou (2) ou (3) ainsi que leurs mélanges, formules dans lesquelles Rl, R2, R4 représentent indépendamment les uns des autres hydrogène, un groupe alkyle ou alkylène présentant 1 à 8 atomes de carbone ou un groupe alcoxy présentant 1 à 8 atomes de carbone, à condition qu'au moins un des groupes Rl, R2, R4 est différent de H ; R3 représente H ou méthyle ; X représente F, Cl ou CF¿3? et n est égal à 0, 1 ou 2.
Patent CA-2462868-A1 (CA)
Inventor: GUIRE PATRICK E
IPC: C12Q1/68
Filed: 2002-10-04
Abstract: Arrays including microparticles having probe moieties are used for the detection of a target in a sample. Microparticles (104) are immobilized in a polymer matrix (106) and form clustered arrangements (108) on at least a portion of a substrate (102). A detection scheme is performed to detect a marker associated with the target which can be bound to a probe of a clustered arrangement (108).
Patent CA-2463576-A1 (CA)
Title: Acoustically generated images having selected components
Inventor: GARLICK GEORGE F
IPC: A61B8/00
Filed: 2002-10-17
Abstract: An acoustically generated image includes only selected acoustical components.  When an original acoustic signal interacts with an object, the resultant acoustic signal comprises a diffracted component and an undiffracted component. The acoustical images of the present invention are generated with either the diffracted component only or the undiffracted component only. In an alternative embodiment, the acoustically generated image may comprise selected frequency component(s) from the diffracted component of the acoustic signal.
Patent CA-2463969-A1 (CA)
Title: Gel release device
Inventor: STEWART JOHN FOREMAN
IPC: E21B47/01
Filed: 2002-11-06
Abstract: The invention relates to a device (1) for holding and releasing an object (3 ), which device comprises: a body (4) with a cavity (5) in which the object is accommodatable; an elastic retaining member (6) for retaining the object in the cavity; a pushing member (7) for pushing the object out of the body past the retaining member; wherein the pushing member comprises a first stimuli responsive gel (8), which has a volume that varies in response to variation of a selected physical stimulating parameter: and control means for controlling the pushing member, by stimulating the first gel.
Patent CA-2464552-A1 (CA)
Inventor: LAUDERDALE BRUCE
IPC: F21V33/00
Filed: 2004-04-15
Abstract: Suspended ceilings of buildings incorporate a T-bar component which is used to provide an integral lighting system. The T-bar component serves as the backbone or a housing member of the lighting fixture as well as an integral part of the suspended ceiling framework.
Patent CA-2465513-A1 (CA)
Inventor: SNOBLE KAREL A J
IPC: B01J20/20
Filed: 2002-10-31
Abstract: L'invention concerne des procédés permettant de produire un solvant organique de grande pureté à partir d'un solvant organique brut, qui consistent à fournir un flux de solvant organique brut contenant une première quantité d'au moins une impureté; et à adsorber au moins une impureté contenue dans ledit solvant sur un adsorbant pour produire un solvant organique purifié qui contient une seconde quantité d'impuretés inférieure à la première quantité d'impuretés.
Patent CA-2466635-A1 (CA)
Title: Sending messages in response to events occurring on a gaming service
Inventor: MULTERER BOYD
IPC: A63F13/12
Filed: 2004-05-07
Abstract: Alerts are transmitted to subscribers to an alerts service in response to events that occur within a gaming environment. Communication within the gaming environment is limited to specific game consoles and the gaming service. A subscriber to the alert notification service can be alerted when a friend joins the gaming service to play a game, or can select other events for which an alert is requested to be sent to the subscriber. In response to any predetermined event occurring within the gaming environment, an alerts service provides an alert or message that is transmitted through a secure firewall and outside the gaming environment. The alert message can be in the form of a pop-up that appears on a user's instant messaging service, or an email, or a message that is transmitted through a mobile communication service to a cell phone or other portable communication device.
Patent CA-2466741-A1 (CA)
Inventor: LEI NING
IPC: F02M45/00
Filed: 2002-11-06
Abstract: L'invention concerne une unité injecteur de carburant (50), cet injecteur préparant de manière interne le carburant lors d'une injection à une pression suffisante pour réaliser l'injection au moyen d'un intensificateur (84) entraîné par un fluide d'activation non-combustible pressurisé, acheminé de manière sélective vers ledit intensificateur (84). L'injecteur selon l'invention comprend une unité de commande (300) pouvant être activée de manière sélective, cette unité de commande étant disposée à l'intérieur d'un passage de carburant (74) établissant une communication fluidique entre une chambre à combustible d'intensificateur et une soupape à pointeau (78), l'unité de commande (300) pouvant être déplacée entre une position ouverte et une position fermée, de sorte à ouvrir et à fermer de manière sélective le passage de carburant (74) pendant l'injection.
Patent CA-2468570-A1 (CA)
Inventor: FRUDAKIS TONY NICK
IPC: G16B40/20
Filed: 2002-12-02
Abstract: Methods and apparatus for use in genetic trait classification involving at least two genes associated with a genetic trait are described. In one illustrative method, a value for use in classifying an individual into one of a plurality of trait classes associated with the genetic trait is calculated.  The value is calculated based on (1) a sum of contributions associated with each genotype of a plurality of genotypes of the at least two genes identified for the individual, where the contributions for each genotype are identified at least in part from statistical associations between the genotypes and each trait class identified in a sample population; and (2) a sum of contributions associated with each one of one or more genotype combinations between the at least two genes identified in the individual, where the contributions for the one or more genotype combinations are identified at least in part from statistical associations between the genotype combinations and each trait class identified in the sample population. Advantageously, epistasis as well as additivity and dominance affects are taken into account for more accurate genetic trait classifications.
Patent CA-2471909-A1 (CA)
Inventor: SAFADI REEM
IPC: G06F21/10
Filed: 2002-12-30
Abstract: Apparatus and methods are provided to allow content protected by different digital rights management schemes from a plurality of content providers to be downloaded, played and/or viewed on a single consumer device, without regard to the original DRM scheme used to protect the content. The present invention acts as a type of proxy agent or intermediary for the consumer that has requested the content. The original DRM scheme of particular content is converted to a native DRM scheme compatible with the consumer device that has requested the content before the requested content is delivered to the consumer device. A network operator (e.g., a content delivery system operator) can therefore interface with multiple content providers having disparate DRM  schemes, while maintaining a consistent DRM scheme on the operator's network and the associated consumer devices.
Patent CA-2473551-A1 (CA)
Title: Context pipelines
Inventor: BERNSTEIN DEBRA
IPC: G06F9/46
Filed: 2003-01-16
Abstract: A method of parallel hardware-based multithreaded processing is described. The method includes assigning tasks for packet processing to programming engines and establishing pipelines between programming stages, which correspond to the programming engines. The method also includes establishing contexts for the assigned tasks on the programming engines and using a software controlled cache such as a CAM to transfer data between next neighbor registers residing in the programming engines.
Patent CA-2474459-A1 (CA)
Title: Outillage d`ecorceur a anneau a moments d`inertie balances
Inventor: PAYEUR JEAN
IPC: B27L1/10
Filed: 2004-07-26
Abstract: La présente invention consiste en un outillage d'écorceur à anneau à moments d'inertie balancés. Lors de l'opération d'écorçage, au lieu d'utiliser un bras conventionnel pour effectuer une pression de la pointe du bras contre l'écorce d'un arbre, on utilise un nouveau bras (24) muni d'un contrepoids (27) à l'extrémité opposée à celle de la pointe (26) du bras. On peut aussi ajouter du poids de balancement aux autres composantes de l'outillage d'écorçage tel que le porte-outil et le levier. L'utilisation d'un contrepoids d'une taille, d'une forme, d'un poids et d'une position convenables pour balancer les moments d'inertie permet de réduire la force appliquée contre l'écorce d'un billot et ainsi réduire la fatigue des pièces de roulement.
Patent CA-2474591-A1 (CA)
Inventor: SENGE MICHAEL
IPC: C08G69/16
Filed: 2003-02-04
Abstract: The invention relates to a device for producing moulded bodies from thermoplastic polymers, starting from monomers that form polymers of this type, in a discontinuous method. Said device comprises a) at least one reactor that is suitable for producing a thermoplastic polymer melt in a discontinuous process starting from monomers that form a polymer of this type, b) a network of pipes that is suitable for circulating the thermoplastic polymer melt and c) at least one device that is suitable for producing moulded bodies from a thermoplastic polymer melt. According to the invention, the reactor or reactors according to a) is/are connected to the network of pipes according to b) and the device or devices according to c) is/are connected to the network of pipes according to b). The invention also relates to a method for producing moulded bodies from thermoplastic polymers in a device of this type.
Patent CA-2475784-A1 (CA)
Title: A method for identification and determination of hypersensitivity of a patient to abacavir
Inventor: MALLAL SIMON
IPC: C12Q1/68
Filed: 2003-02-12
Abstract: A method for identifying whether a patient will exhibit a hypersensitive reaction or like-reaction to treatment with abacavir comprising the step of:  typing the patient for the presence of the 57.1 ancestral haplotype.
Patent CA-2476562-A1 (CA)
Title: Agitator mill
Inventor: GERL STEFAN
IPC: B01F7/16
Filed: 2004-08-05
Abstract: An agitator mill comprises a grinding receptacle and a rotarily drivable agitator arranged therein. A grinding-stock supply mouthes into the grind-ing chamber; a grinding-stock discharge leads out of the grinding chamber.    The grinding chamber is at least partially filled with auxiliary grinding bodies. The grinding-stock discharge is embodied as a device for grinding stock suction and auxiliary-grinding-body separation, comprising a plunge pipe which dips into a bed of grinding stock and auxiliary grinding bodies and from which, above the grinding receptacle, discharges a suction pipe with a grinding-stock suction device.
Patent CA-2476600-A1 (CA)
Title: Radiation detector arrangement comprising multiple line detector units
Inventor: ULLBERG CHRISTER
IPC: G01T/
Filed: 2003-02-14
Abstract: A radiation detector arrangement for imaging of an object comprises multiple line detector units (41), each being arranged for one-dimensional imaging of the respective ray bundle. The detector units are arranged parallel in a two-dimensional array. The detector units are sited in rows (44; 61) and stacks (45; 63), the rows being parallel with the detector unit and the stacks being orthogonal thereto, where the one-dimensional detector units in each row are together capable of detecting the object in one dimension. A device (87-89, 91) is provided for moving the detector units relative the object parallel with the stacks at least a distance corresponding to the distance (s1~) between two adjacent detector units in the stacks.
Patent CA-2480178-A1 (CA)
Title: Methods for producing secreted polypeptides having l-asparaginase activity
Inventor: SLOMA ALAN
IPC: C12N1/21
Filed: 2003-04-01
Abstract: The present invention relates to recombinant methods for producing a secreted polypeptide having L-asparaginase activity, comprising (a) cultivating under conditions conducive for production of the polypeptide a host cell comprising a nucleic acid construct comprising a first nucleic aci d sequence encoding a secretory signal peptide operably linked to second nucle ic acid sequence encoding the polypeptide having L-asparaginase activity, where in the signal peptide directs the polypeptide into the cell's secretory pathway ; and (b) recovering the secreted polypeptide. The present invention also relates to isolated polypeptides having L-asparaginase activity and nucleic acids thereof.