baber/WOPTO huggingface dataset:
Patent NZ-531780-A (NZ)
Title: Radioactive arsenic-containing compounds and their uses in the treatment of tumors
Inventor: HUANG CHUN-YING
IPC: A61K41/00
Filed: 2004-03-17
Abstract: A pharmaceutical composition, comprising: (a) a therapeutically effective amount of a radioactive arsenic-containing compound, being prepared by a process comprising the steps of: - (i) subjecting an arsenic-containing compound selected from As2O3, As2S3, As2S2, or a combination, to a neutron irradiation treatment such that the arsenic element is converted to a radioactive arsenic isotope, and - (ii) recovering the resultant product from step (i), and (b) a pharmaceutically acceptable carrier. The above pharmaceutical composition is used in methods of treating tumours or cancers.
Patent NZ-533536-A (NZ)
Title: Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol such as O-phosphonooxymethyl propofol
Inventor: ROGERS TRACEY L
IPC: A61K31/05
Filed: 2002-12-26
Abstract: Disclosed herein are aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol and an effective amount of an antioxidant. Particularly disclosed is a pharmaceutical formulation comprising in an aqueous medium: (i) a therapeutically effective amount of a compound represented by the formula (I), wherein each Z is independently selected from the group consisting of hydrogen, alkali metal ion, and amine; and (ii) an effective amount of an antioxidant. Optionally the formulation may also contain a tonicity modifier. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. Advantageously, the formulations can be prepared without the use of harmful co-solvents or surfactants, and are stable at room temperature over extended periods of time.
Patent NZ-533688-A (NZ)
Title: Materials from bone marrow stromal cells for use in forming blood vessels and producing angiogenic and trophic factors
Inventor: CHOPP MICHAEL
IPC: A61K35/30
Filed: 2003-01-14
Abstract: A therapeutic for use in inducing angiogenesis and vasculogenesis, the therapeutic including angiogenesis and vasculogenesis inducing factors isolated from stem cells in conjunction with a pharamaceutically acceptable cell therapy. A method of amplifying the production of angiogenesis and vasculogenesis inducing factors secreted by exposing stem cells to and co-culturing the stem cells with a compound for increasing the production of angiogenesis and vasculogenesis inducing factors. Angiogenesis and vasculogenesis inducing factors isolated and purified from stem cells for use in a therapy. A process for obtaining the angiogenesis and vasculogenesis inducing factors as set forth above, the process including the steps of isolating and purifying human mesenchymal stem cells from tissue prior to differentiation and then culture expanding the mesenchymal stem cells to produce a tool for neurological and musculoskeletal therapy. Isolated and culture expanded mesenchymal stem cells under the influence of a requisite compound, that are capable of differentiating and producing a desired cell phenotype needed for tissue repair.
Patent NZ-534393-A (NZ)
Title: Roaster
Inventor: RAGAN GARY
IPC: A47J37/06
Filed: 2003-01-10
Abstract: A roaster includes an upper pan including an upper side wall and an upper pan heating element inside the upper tub. The roaster further includes a lower pan connected to the upper tub, the lower pan including a lower side wall and a lower pan heating element inside the lower tub. An upper pan fixed temperature regulator and a lower pan fixed temperature regulator may be preset to different selected temperatures. The roaster may also include a grease drain opening through the lower tub. Temperature and timer control logic are provided for the upper pan heating element and the lower pan heating element. In order to set cooking time, the roaster includes a control interface that includes, in one embodiment, a time increment button and a time decrement button.
Patent NZ-535188-A (NZ)
Title: Dispenser
Inventor: BACON RAYMOND JOHN
IPC: A61M15/00
Filed: 2004-09-08
Abstract: A dispenser for a gaseous, gas borne or droplet substance contained in a source thereof, the dispenser including a body with a mouthpiece and a junction member in the body for the substance source. A breath actuable valve for controlling the release of the gas or liquid continuing or comprising the substance. the valve comprising a flexible tube for receiving the gas or liquid where the tube extends from an inlet valve connected to the junction member and having a portion which is kinkable for the closure of the valve and moveable to an open unkinked position. A member is also arranged for movement in the body by inhalation to un-kink the tube/valve. The tube being unlinked to an obturating extent when the movable member is in a ready position and unkinked when the movable member is moved on inhalation for release of the gas or liquid. The dispenser further includes a spring for assisting the movement to un-kink the tube and means are provided to hold the movable member in the ready position to close the tube by kinking prior to inhalation. (62) Divided out of 524081
Patent NZ-535338-A (NZ)
Title: Road safety barriers including four or more ropes held in tension against posts following a sinuous path between them
Inventor: SHARP GRAHAM T
IPC: E01F15/06
Filed: 2004-09-15
Abstract: A road safety barrier comprises four or more ropes (4,5,6,7) supported by posts (8, 9,10) rigidly mounted on or in the ground, each rope is held against the posts (8,9,10) and following a sinuous path between posts. The ropes (4,5,6,7) are tensioned against the posts (8,9,10) and give rise to a combined frictional resistance to displacement of the ropes relative to each post along the length of the safety barrier and the structure of at least some of the posts and/or their mourning with respect to the ground defines a minimum bending yield strength is greater than the bending moment resulting from the combined frictional resistance forces acting on the post, whereby the minimum bending yield strength is greater than the bending moment resulting from the combined frictional resistance forces acting on the post.
Patent NZ-538388-A (NZ)
Title: Drug discovery method
Inventor: OFER DROR
Filed: 2002-07-24
Abstract: A method of obtaining information about at least one chemically active area of at least one target molecule, comprising: providing a set of compounds comprising a plurality of substantially rigid chemical gauges, each of said gauges consisting of a rigid scaffold and at least one moiety connected thereto by a rotationally free single covalent bond; each of said plurality of gauges providing at least one substantially rigid triangular geometric substructure of binding points, such that at least 50% of a mathematical-chemical space is spanned by the substantially rigid triangular geometric substructures of said gauges, each point in said space being covered by at least 5 distinct gauges from said set, said mathematical-chemical space being defined using a list of at least six chemical binding point types, including acid, base, hydrophobic, hydrogen-bond donor, hydrogen-bond acceptor, aromatic, and a range of possible distances between chemical binding points including the range of 2-12 angstrom, said list and said range defining a space of possible triangular configurations, each configuration including a triplet of distances within said range that form a triangle and a triplet of binding types for the triangle vertices; and a portion of said space being defined as being spanned if there is at least one substantially rigid triangular substructure available to chemically bind to a triangular configuration of binding points selected in said portion; causing said at least one target to interact with said plurality of gauges; measuring the interaction of said gauges with at least one of said at least one target to obtain a plurality of assay results; and analyzing said assay results to obtain information about said at least one chemically active area.
Patent NZ-544603-A (NZ)
Title: Percutaneous electrode array
Inventor: CARTER JOHN
IPC: A61N1/18
Filed: 2004-04-14
Abstract: A percutaneous electrode array (300) for delivering therapeutic electrical energy to a patient is disclosed. The percutaneous electrode array (300) includes (a) a substrate (310) having a top side and a bottom side, and (b) a plurality of electrodes (320) that each has a proximal end, a distal end, an axis from the proximal end to the distal end, and a length along the axis. Each electrode (320) is attached to the top side of the substrate (310), whereby each electrode (320) has a thinned and pointed end. The electrodes (320) have a total surface area of more than 0.2 square centimetres.
Patent NZ-546327-A (NZ)
Title: Number plate anti-rattle cushioning gasket
Inventor: SMITH ANDREW ROBERT WILLIAM
Filed: 2006-03-31
Abstract: A gasket to be inserted between a number plate and the vehicle mount to cushion the plate and prevent it from rattling, includes a PVC sheet cut to the shape of a "spider", with adhesive foam pads attached to portions of the "feet" and "body" of the spider.
Patent NZ-546509-A (NZ)
Title: Bispecific antibody substituting for functional proteins wherein the antibody can recognize both a proteolytic enzyme and a substrate thereof such as blood coagulation/fibrinolysis associated factors
Inventor: HATTORI KUNIHIRO
IPC: A61P7/00
Filed: 2004-10-08
Abstract: Disclosed is an antibody recognizing both a proteolytic enzyme and a substrate thereof, wherein said antibody is a bispecific antibody which functionally substitutes for a cofactor that enhances the enzymatic reaction. Further disclosed is an antibody recognizing coagulation/fibrinolysis associated factors. In a preferred embodiment the enzyme of a blood coagulation/fibrinolysis associated factor is blood coagulation factor IX and/or activated blood coagulation factor IX; the substrate is blood coagulation factor X; and the cofactor is blood coagulation factor VIII and/or activated blood coagulation factor VIII.
Patent NZ-548949-A (NZ)
Title: Novel cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein
Inventor: HONDA TAKAHIRO
IPC: A61P43/00
Filed: 2005-02-17
Abstract: Disclosed is a compound which possesses a 4-pyridylalkylthio group with a substituted or unsubstituted amino group introduced therein, as represented by the following general formula (1). Ring A represents a benzene ring, or an aromatic 5 or 6-membered heterocyclic ring (such as a thiophene ring or a pyridine ring), and the other substituents are defined herein. Also disclosed is a pharmaceutical composition which comprises the above compounds or a salt thereof as an active ingredient. In addition, the use of a compound or salt thereof as defined above in the production of a medicament for treating a disease involving angiogenesis or vascular hypermeability (such as cancer, rheumatoid arthritis, age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, polypoid choroidal angiopathy, diabetic macular edema, psoriasis vulgaris or atherosclerosis) is also disclosed.
Patent NZ-550370-A (NZ)
Title: Piperazinylpiperidine derivatives as chemokine receptor antagonists
Inventor: XUE CHU-BIAO
IPC: A61K45/06
Filed: 2005-04-12
Abstract: Disclosed are compounds of Formula (I), wherein R1 is heteroaryl and the remaining substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections such as HIV.
Patent NZ-550892-A (NZ)
Title: Antimycobacterial pharmaceutical composition comprising an antitubercular drug
Inventor: ARORA SUDERSHAN KUMAR
IPC: A61K45/06
Filed: 2004-08-27
Abstract: Disclosed is an antimycobacterial combination comprising a therapeutically effective amount of N-(3-[[4-(3-trifluoromethyl phenyl)piperazinyl]methyl]-2-methyl-5-phenyl-pyrrolyl)-4-pyridylcarboxamide of formula (I) or a pharmaceutically acceptable nontoxic salt thereof and a therapeutically effective amount of one or more first line antitubercular drugs selected from the group consisting of isoniazid, rifampicin, ethambutol and pyrazinamide.
Patent NZ-556354-A (NZ)
Title: 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
Inventor: LINDEN JOEL M
IPC: A61K31/4015
Filed: 2002-10-01
Abstract: The present disclosure comprises compounds and their use for the treatment of inflammatory activity in mammalian tissue. The inflammatory tissue activity can be due to pathological agents or can be due to physical, chemical or thermal trauma, or the trauma of medical procedures such as organ, tissue or cell transplantation, angioplasty (PCTA), inflammation following ischemia/reperfusion, or grafting. The present compounds of general formula (I), wherein variables shown in formula (I) are as defined in the specification, comprise a novel class of 2-alkynyladenosine derivatives, substituted at the ethyn-2-yl position by substituted cycloalkyl and heterocyclic moieties.
Patent NZ-568505-A (NZ)
Title: A wind turbine
Inventor: ORSBORN ANTHONY
IPC: F03D3/02
Filed: 2008-05-21
Abstract: A wind turbine with a vertical axis of rotation. The wind turbine includes at least one set of blades connected to a travel assembly which engages a closed loop track, the track being inclined with respect to the vertical axis of rotation. The blades are also connected to the rotating frame via a blade arm in a manner that allows for the blades to be capable of rotating about a substantially horizontal axis as dictated by the relative position of the travel assembly on the track and wherein the wind causes the frame to rotate about the vertical axis upon catching the blades. Each blade arm includes: a proximate portion of the blade arm adjacent to the travel assembly, which is angled with respect to a distal portion of the blade arm attached to the blade; a first bearing intermediate between the proximate portion and the distal portion to allow rotation of the blades about a substantially horizontal axis; and a second bearing intermediate between the proximate portion and the first bearing to allow for rotation of the proximate portion relative to the distal portion.
Patent NZ-571700-A (NZ)
Title: Bags provided with a slider-operated reclosable pour spout
Inventor: SCHNEIDER JOHN H
IPC: B65D75/58
Filed: 2007-03-22
Abstract: A package has a re-closable pour spout with a slider-operated zipper. The package comprises: a receptacle (2) having an interior volume and a spout that, when in an opened state, allows access to the interior volume, the receptacle (2) having first and second sides, and the spout starting near the first side and extending toward but not coming near the second side; a length of flexible zipper (6,8) arranged to close the spout when the zipper is closed; and a slider (10) mounted to the zipper, the slider being movable in a closing direction for closing the zipper and movable in an opening direction for opening the zipper.
Patent NZ-577990-A (NZ)
Title: Expansion feature for neck-receiving openings in an article carrier
Inventor: PAPASOTIRIOU GEORGE
IPC: B65D71/00
Filed: 2007-11-12
Abstract: An article carrier (300) and a blank (100) is disclosed. Neck-receiving apertures for receiving the necks of the articles include expansion features that maintain a snug fit around articles having various cross- sectional neck sizes, while protecting the integrity of the apertures and the surrounding carrier walls. More specifically, the expansion feature flexes to receive the article neck and to permit movement of the article neck within the aperture, but variably enlarges and reduces the aperture to maintain constant contact between the article and the aperture. Without the expansion feature, the aperture would have to be made larger than the neck to accommodate its diameter and provide some play, or would be subject to tearing if the article shifted within the aperture. The carrier has a plurality of walls or panels, connected to one another so as to fold. At least one opening (120) for receiving the neck (N) of an article (A) is made in one of the walls. Each opening has an aperture (122) that is defined by a peripheral edge (E). A collar (C) extends along a portion of the peripheral edge, the collar being defined at least in part by the peripheral edge and by at least a first severance relief line (124a) which is spaced apart from the peripheral edge, the collar being deflectable to variably and reversibly enlarge the aperture. Another relief severance line extends from the peripheral edge, the length of this single severance line being greater than the distance of the first severance relief line from the peripheral edge.
Patent NZ-581774-A (NZ)
Title: Earthquake damper for installation on a joint between framework members
Inventor: OHASHI YOSHIMITSU
IPC: F16F15/08
Filed: 2008-06-06
Abstract: Disclosed is an earthquake damper with a first plate member (11) fixed to one framework member (51), a second plate member (13) fixed to the other framework member (53), and an elastic member (15) placed between the first plate member (11) and the second plate member (13). A first gap W1 is formed between the other framework member (53) and a first installation section (21), and a second gap W2 is formed between the one framework member (51) and a second installation section (29). Also, the first plate member (11) is constructed from a steel plate member formed so as to direct from the first installation section (21) to the second installation section (29), and the second plate member (13) is constructed from a steel plate member formed so as to direct from the second installation section (29) to the first installation section (21). Further, a space (50) formed by the first gap W1, the second gap W2, the first plate member (11), and the second plate member (13) has a size through which at least a floor beam (57) can be inserted. The earthquake damper can be reliably installed on a joint between the framework members.
Patent NZ-588541-A (NZ)
Title: Systems and methods for managing gaming activities
Inventor: AMOUR MARC
IPC: A63F9/24
Filed: 2010-09-22
Abstract: A computer implemented method for managing data in relation to a gaming activity where a plurality of players provides respective contribution amounts in consideration for an opportunity to win a common prize subject to a common prize determination process is disclosed. The method includes: (a)providing an interface for allowing a given player to provide data indicative of a cause selection, wherein the data indicative of a cause selection designates at least one of a plurality of available cause selections; (b)for each player, determining a value for allocation to a cause identified by that player’s cause selection; and (c)maintaining a database for facilitating the allocation of the respective players’ values to the respective causes, thereby to facilitate allocation to a plurality of causes respective portions of an overall sum of value available for allocation.
Patent NZ-589418-A (NZ)
Title: Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
Inventor: MORGAN LEE
IPC: A61K31/66
Filed: 2005-10-25
Abstract: A sterile composition comprising a isophosphoramide mustard compound of structural formula shown herein is disclosed, wherein X and Y independently represent leaving groups, or a pharmaceutically acceptable salt thereof; and wherein the compound is present with less than 10% decomposition products relative to the compound itself. A method of purifying a salt of said isophosphoramide mustard compound is also disclosed, wherein the method comprises filtering a solution of the compound through a sterile antimicrobial filter, whereby the purified compound undergoes less than 10% decomposition during filtration. These sterile compositions are suitable for treatiing hyperproliferative disorder selected from breast cancer, bladder cancer, bone cancer, cervical cancer, colon cancer, central nervous system cancer, esophageal cancer, gall bladder cancer, gastrointestinal cancer, head and neck cancer, Hodgkin's Disease, non-Hodgkin's lymphomas, laryngeal cancer, leukemia, lung cancer, melanoma, neuroblastoma, ovarian cancer, pancreatic cancer, prostate cancer, rectal cancer, renal cancer, retinoblastoma, stomach cancer, testicular cancer and Wilms tumor.
Patent NZ-601388-A (NZ)
Title: Milk derived antigen specific antibodies for inducing an adaptive immune response, methods of preparation and uses thereof
Inventor: VAN NEERVEN RUPRECHT JULES JOOST
IPC: A61K39/395
Filed: 2011-01-14
Abstract: Disclosed is the use of an antigen-specific antibody obtained from the milk, milk product, colostrum, or colostrum product of a ruminant, for the manufacture of a medicament for enhancing and/or inducing an adaptive immune response against an antigen in an individual to which the antibody has been administered. Also disclosed is the use of a ruminant, antigen-specific antibody obtained from milk, milk product, colostrum, or colostrum product of a ruminant, for the manufacture of a medicament for delaying the onset or reducing the severity of one or more symptoms of a disorder selected from an allergic disease, an autoimmune disease, an infectious disease, and/or an inflammatory disease in an individual at risk of developing said disease.
Patent NZ-607273-A (NZ)
Title: Ncpap to lower breathing effort
Inventor: MANSOUR KHALID
IPC: A61M39/08
Filed: 2011-08-16
Abstract: A nasal continuous positive airway pressure device for lowering patient breathing effort comprising: an inspiratory tubing (102) in fluid communication with at least two nasal prongs (104); expiratory tubing (106); and a generator body (108) coupled therebetween, the generator body comprising: at least two jets (110a, 110b) for receiving gas from the inspiratory tubing; and a flow enhancer (112) for directing received gas, the flow enhancer comprising: a gas manager configured for channelling received gas towards a jet impingement point (116) via at least two jet paths (118a, 118b); a fluidic flip trigger configured for triggering a fluidic flip of channelled gas back towards the expiratory tubing by directing a first portion of exhaled patient breath towards the jet impingement point along a first pathway (122); and an isolated pathway manager for directing a second portion of the exhaled patient breath along a second pathway (126) towards the expiratory tubing, the second pathway isolated from the first pathway.