Patent SG-11202000112X-A (SG)
Title: Trimer stabilizing hiv envelope protein mutations
Inventor: LANGEDIJK JOHANNES
IPC: C07K14/005
Filed: 2018-07-12
Abstract: 6 19 July 2017 (19.07.2017) EP 17191083.9 14 September 2017 (14.09.2017) EP 18158862.5 27 February 2018 (27.02.2018) EP 18178358.0 18 June 2018 (18.06.2018) EP (71) Applicant: JANSSEN VACCINES & PREVENTION B.V. [NL/NL]; Archimedesweg 4, 2333 CN Leiden (NL). (72) Inventors: LANGEDIJK, Johannes, Petrus, Maria; Archimedesweg 4-6, 2333 CN Leiden (NL). RUTTEN, Lucy; Archimedesweg 4-6, 2333 CN Leiden (NL). STROKAPPE, Nika, Mindy; Archimedesweg 4-6, 2333 CN Leiden (NL). TRUAN, Daphne; Archimedesweg 4-6, 2333 CN Leiden (NL). (74) Agent: VERHAGE, Richard, A et al.; Archimedesweg 4-6, 2333 CN Leiden (NL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS (57) : Human immunodeficiency virus (HIV) envelope proteins having specified mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield. Also provided are particles displaying the HIV envelope proteins, nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, particles, nucleic acid, or vectors. (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo oimIE (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/016062 Al (43) International Publication Date 24 January 2019 (24.01.2019) WIP0 I PCT (51) International Patent Classification: A61K 39/12 (2006.01) CO7K 14/005 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/EP2018/068900 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art 21(3)) with sequence listing part of description (Rule 5.2(a)) 12 July 2018 (12.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: W O 20 19/0 1606 2 Al