baber/WOPTO huggingface dataset:
Patent EC-SP088306-A (EC)
Title: Agentes para prevenir y tratar los trastornos que involucran la modulación de los receptores ryr
Inventor: MARKS ANDREW ROBERT
IPC: A61K31/554
Filed: 2008-03-24
Abstract: La presente invención suministra compuestos de la Fórmula I: y sus sales, hidratos, solvatos, complejos y prodrogas. La presente invención suministra además métodos para sintetizar los compuestos de la Fórmula I. La invención suministra adicionalmente composiciones farmacéuticas que comprenden los compuestos de la fórmula I y métodos para usar las composiciones farmacéuticas de la Fórmula I para tratar y prevenir trastornos y enfermedades asociados con los receptores RyR que regulan el canal de calcio que funciona en las células.
Patent EC-SP930913-A (EC)
Title: Gel tixotropico adhesivo
Inventor: COLUMBUS PETER SPIROS
IPC: C08F2/16
Filed: 1993-03-04
Abstract: Se enseña un gel tixotrópico adhesivo basado en agua, que consiste esencialmente en agua, alcohol polivinílico parcialmente hidrolizada, o en el cual una porción del alcohol polivinílico se reemplaza por polivinilpirrolidona, un agente polimérico espesante de alta viscosidad soluble en agua, que sea compatible con el alcohol polivinílico, y que importa propiedades tixotrópicas al gel, un plastificador soluble en agua en proporciones de ingredientes tales que la viscosidad del adhesivo se destruirá cuando un dispensador de tubo flexible o de botella aplastable se presiona con los dedos y tiene una viscosidad suficientemente baja para permitir la fácil extrusión desde un orificio que tiene un diámetro de cerca de 0.1524 a 0.381 cm (0.06 a 0.15) pulgadas). Cuando la presión se libera, después de que la cantidad deseada de adhesivo ha fluído fuera del dispensador, el adhesivo revierte rápidamente a un estado muy próximo al estado original del gel, de modo que no se correrá sobre una superficie porosa o semi-porosa vertical, tal como papel.Se proveé también un artículo de manufactura en el cual el gel adhesivo que contiene los ingredientes anteriores, está en un dispensador flexible desde el cual puede dispensarse el adhesivo por presión de los dedos.
Patent EC-SP993227-A (EC)
Title: Prodrogas hidrosolubles de compuesto azole
Inventor: ZHENG XIAOZHANG
IPC: A61K9/00
Filed: 1999-11-19
Abstract: Se proveen prodrogas hidrosolubles de compuestos antimicóticos triazoles que tienen un grupo hidroxi terciario o secundario. Más particularmente, se proveen nuevos compuestos antimicóticos triazoles hidrosolubles que tienen la fórmula general (gráfico), en la que A es la porción no hidroxi de un compuesto antimicótico triazole, del tipo que contiene un grupo hidroxil secundario o terciario y n, m, p R1, R2, R3 y R4 son como se define en la especificación.
Patent EC-SP993255-A (EC)
Title: Compuestos organicos
Inventor: VILLHAUER EDWIN BERNARD
IPC: A61K31/40
Filed: 1999-12-09
Abstract: La presente invención se refiere a un compuesto de la fórmula I (grágico), en donde R es adamantilo sustituido; y n es de 0 a 3; en forma libre o en forma de sal de adición de ácido. Los compuestos de la fórmula I inhiben la actividad de DPP-IV(peptidiasa de dipeptidilo-IV). Por consiguiente, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP-IV, y en el tratamiento de condiciones mediadas por DPP-IV, tales como diabetes mellitus no dependientes de insulina, artritis, obesidad, osteoporosis, y otras condiciones de tolerancia deteriorada a la glucosa.
Patent GB-1050265-A (GB)
IPC: G07F5/26
Abstract: 1,050,265. Vending machines. CORNELIUS CO. Sept. 16, 1963 [June 13, 1963], No. 36412/63. Heading G4V. In a vending machine in which one only of a number of doors may be opened after payment to a single coin-freed mechanism, each door such as 11, Fig. 5, is rotatably mounted on a common shaft 15 by a hub 17, Fig. 3, on which a control member 20 is fixed. Between each pair of members 20, a slider 26 is located in guides 27. When any one door is opened, a cam surface 21 on its member 20 engages roller 28 on the slider above, to raise that and all higher sliders, so that their notches 29 engage and lock the members 20 of all higher doors. A surface 25 on the operated member 20 engages a surface 32 on the slider below, to lock that and all lower sliders in place, preventing opening of any lower door. Each hub is connected to shaft 17 by a lost motion pin and slot coupling, so that opening of any one door results in rotation of shaft 15 and an arm 36, Figs 5. A locking member 37 is pivoted to arm 36, and to rod 43. Until the correct coinage is inserted, rod 43 is baulked, and an attempt to open a door pivots member 37 against spring 42 to engage hook 45 with abutment 46, to protect rod 43 against excessive force. Spring 42 serves to release lock 37 when the force ceases, and to return shaft 15 and to close any opened door after use.
Patent GB-1096805-A (GB)
Abstract: 1,096,805. Dividing by a single blade. GESELLSCHAFT FUER KERNFORSCHUN G.m.b.H. Sept. 23, 1966 [Oct. 9, 1965], No. 42472/66. Heading B3W. [Also in Division G6] An irradiated nuclear fuel element 2 is advanced by rollers 1 between cutting rollers 3 forming longitudinal cuts in the element can, fuel material adhering to the can being removed by a hollow rotary drill 4 having an outside diameter equal to the inside diameter of the can. The segments 10 of the slit can are expanded and scraped by a hollow stationary cutting tool 5, these segments being cut by shear tools 11a biased by return springs 13 and operated by a rotary cam ring 12. The fuel material drops into a vessel 16 through ducts 7, 11 and the can material drops into a vessel 17 through a duct 8.
Patent GB-1226033-A (GB)
IPC: F15B7/00
Filed: 1968-09-12
Abstract: 1,226,033. Electro-machining tools. H. J. BILLING. Aug.13, 1969 [Sept.12, 1968], No. 43311/68. Heading C7B. [Also in Division F1] An electro-chemical machining head comprises a tool carrying rod c fixed to a piston b slidable in a cylinder a by liquid pumped past a non-return valve w into cylinder space m, the liquid in the cylinder space j on the other side of the piston being expelled to a variable volume chamber k having a spring-loaded wall l. The variable volume chamber shown is annular and surrounds the cylinder u but it may be a separate accumulator chamber connected by a pipe to the space j, Figs. 2 & 3 (not shown). To move the piston b in steps a pump, Fig. 4, is used to supply the space m. The pump comprises a plunger 3 having a hammer face 11 which is hit by a hammer 12, 13 propelled by a solenoid 2. The solenoid is operated at intervals as determined by a timing device 10.
Patent GB-1230399-A (GB)
IPC: B63B25/04
Filed: 1968-08-07
Abstract: 1,230,399. Cargo ships. JOHN J. McMULLEN ASSOCIATES Inc. 7 Aug., 1968 [10 Aug., 1967; 18 July, 1968], No. 37716/68. Heading B7S. A cargo ship 1 has displaceable shifting boards 100 located fore-and-aft and substantially aligned with the port and starboard hatch edges (e.g. coamings 6), a storage enclosure 22 wholly removed from the cargo space and means (e.g. a winch, cable 142, capstan 130 and pulley 132) for moving the boards the enclosure and their position in the cargo space as fore-and-aft bulkheads. The ship may have auxiliary hatch covers 8 to enable more of the cargo space to be utilized for cargo. An alternative form of shifting board is also shown comprising upper and lower panels which are drawn up beside each other in the enclosure 22.
Patent GB-1231851-A (GB)
Filed: 1968-01-22
Abstract: 1,231,851. Measuring torsion electrically. NATIONAL RESEARCH DEVELOPMENT CORP. April 2, 1969[Jan.22, 1968], No.3272/68. Heading G1J and G1N. [Also in Division F2] Apparatus for determining the torque/angular twist characteristic of a specimen 10 comprises an electric motor, 35, driving a first chuck, 12, gripping an end of the specimen its other end being held motionless by a second chuck, 11, which is connected to the frame of the apparatus by a steel member 25 bearing a strain gauge 29. In use, the motor drives the first chuck through a change-ratio gear-box 34 and also drives a chart recorder 31 of which the pen is deflected by a voltage from the strain gauge, amplified at 30. Fig.2 (not shown) illustrates the chuck 11 and Fig.3 (not shown) illustrates a bar which may be attached to the face of the chuck 11 for purposes of calibration. Fig.4 (not shown) illustrates the shear stress (torque divided by polar modulus) versus angular twist characteristic obtained for a titanium specimen. Fig. 5 (not shown) illustrates an arrangement for preventing rotation of the chuck 12 until all the play in the driving members is taken up (see Division F2) which arrangement reduces non-linearity in the torque/twist characteristic.
Patent GB-1232288-A (GB)
IPC: B23K9/00
Filed: 1968-06-19
Abstract: 1,232,288. Welding by fusion. FOSTER WHEELER CORP. 19 June, 1968 [30 June, 1967], No. 29291/68. Heading B3R. Tube-panel welding apparatus for making elongate welds between tubes to form a tubepanel, comprises a carrier vehicle 16 capable of being moved in contact with tubes to be welded, a welding unit 18 movably mounted on the carrier vehicle, and means connecting the carrier vehicle and welding unit for positioning the unit at a predetermined lateral spacing from adjacent tubes to be welded. The carrier vehicle has two pairs of wheels (44, 46) (Fig. 5, not shown) mounted on split axles, one of which is driven by an electric motor via a clutch and bevel gear, one pair of wheels (44) having peripheral grooves whereby they run on and along a tube. The welding unit 18 includes a welding gun 138 fed by a wire-feed unit 30 with welding wire from a reel mounted on the carrier vehicle, a suction nozzle 156, connected to a retort 172 and a compressed-air created vacuum source, for removing spent flux, and a flux-depositing nozzle 154 connected by gravity feed to a fluxhopper 164. The welding unit is mounted on a wheeled vehicle 200 such that the height of the unit from the tubes to be welded is adjustable by a mechanism 252 and the lateral spacing of the unit from the axes of adjacent tubes to be welded is adjustable by a mechanism 254. The vehicle 200 has four wheels 308 simultaneously adjustable in inclination, whereby the spacing between opposite wheels is adjustable according to the diameter of a tube on which they have to run. The vehicle 200 is connected to the carrier vehicle 16 by an arrangement of two arms 202, 224 which allows vehicle 200 to be lifted or adjusted vertically and to be moved laterally to run on another tube without moving the carrier vehicle until the range of lateral movement of vehicle 200 is reached. This arrangement includes a universal joint 204 connecting arm 202 to a plate mounted on the carrier vehicle, the other end of arm 202 being secured to a cylindrical pillar 244 of the vehicle 200. Arm 224, which is pivoted about a vertical pin to a block 110 on the carrier vehicle, receives a vertical post 222 hinged at 220 to arm 202, and providedadjacent arm 224 with a lever cam 234 rotation of which in an anti-clockwise direction (as seen in the drawings) causes the post 222 to move upwards in a bore 226 in arm 224, whereby the vehicle 200 is lifted clear of the work. The apparatus includes a welding console (24) (Fig. 13, not shown), welding power supply (25), timer control (26) and magnetic amplifier (27).
Patent GB-1238367-A (GB)
IPC: C21D9/08
Filed: 1968-11-11
Abstract: 1,238,367. Annealing by induction. BETA INSTRUMENT CO. Ltd. Nov. 11, 1969 [Nov. 11, 1968], No. 53364/68. Heading C7N. The invention comprises a process and an apparatus therefor for annealing flexible metallic material comprising drawing the material by means of a first electric motor through an annealing device in which a length of the material is magnetically coupled to an induction coil, shortcircuiting the said length so that induced current in the length heats the material, tensioning the material by means of a second electric motor, and controlling the tension of the material by a tensioning device operating on the second electric motor and as described in Specification 1,194, 771. (see Division G3). Preferably the material is quenched, in e.g. oil or water, after annealing; is annealed in an inert atmosphere, e.g. steam, or nitrogen. The power input to the induction coil may be varied in proportion to the speed of flexible material through the device.
Patent GB-1238708-A (GB)
IPC: B65G17/48
Filed: 1968-11-07
Abstract: 1,238,708. Endless swing-tray type conveyers. BAKER PERKINS Ltd. 7 Nov., 1968, No. 52833/68. Heading B8A. Swing trays 6 in a bakery conveyer have superposed product supporting shelves 7, 8 the distance between which is adjustable during the conveyer travel. The upper shelf 7 is movable upwardly from its normal position relative to the lower shelf 8 by the action of linear cam members 20, 20 engaging rollers 17, 17, of a linkage 16. The shelves 7, 8, comprise spaced bars (9) (Fig. 3, not shown) which interleave with similar fixed bars 18 at a feed or discharge station the products (not shown) thus being transferred by a combing action in conjunction with pushers 19.
Patent GB-1238961-A (GB)
IPC: C01G45/04
Filed: 1968-01-03
Abstract: 1,238,961. Dimanganese decacarbonyl. IMPERIAL CHEMICAL INDUSTRIES Ltd. 2 Jan., 1969 [3 Jan., 1968], No. 477/68. Heading C1A. Dimanganese decacarbonyl is prepared by the reaction of cyclopentadienyl manganese tricarbonyl, or a substituted derivative thereof, with carbon monoxide in the presence of an alkali metal, diglyne and a polynuclear aromatic hydrocarbon. The hydrocarbon is preferably naphthalene or anthracene and the preferred starting materialis methylcyclopentadienyl manganese tricarbonyl. The introduction of the carbon monoxide is preferably delayed until reaction with the alkali metal, preferably sodium, is complete. The process is preferably carried out at atmospheric pressure, and the dimanganese decacarbonyl is recovered by (1) destroying excess alkali metal with alcohol, (2) acidifying the mixture and (3) removing the product by steam distillation.
Patent GB-1256957-A (GB)
IPC: B65D30/08
Filed: 1969-03-14
Abstract: 1,256,957. Block-bottomed bag. CRAFSAC. 14 March, 1969 [15 March, 1968; 4 Feb., 1969], No. 13549/69. Heading B8K. A block-bottomed bag is formed by inserting a tube of plastics material into at least one tube of paper ply, flattening the tubes and applying a transverse stripe of anti-adhesive material to the edge of the inner surface of the or the inner paper ply along one flattened half only, welding along the line of anti-adhesive so that the plastics lining is joined to the other flattened half of the inner paper ply, and then folding and adhesively sealing the end of the bag. The paper plies 2-4 and lining member 6 may be longitudinally staggered and this, together with the degree of overlap on folding the bag end, may be varied as follows:-(a) lining 6 and ply 2 level, but staggered with respect to plies 3 and 4 (Fig. 5), with the transverse edges of ply 2 overlapped on folding, (b) ply 3 staggered with respect to ply 4 (Fig. 1, not reproduced), and the transverse edges of ply 2 meeting on folding, (c) plies 2, 3, 4 level, but staggered with respect to lining 6 (Fig. 8, not reproduced) and the transverse edges of all paper plies overlapped on folding. The lining member may be provided with bellowed edges (see Fig. 1). The bag end is folded diamond-wise in conventional manner and sealed with one or more adhesive papers 13. Welding may be performed by direct heating, dielectric heating or ultrasonic fusion. Conventional tube- and bag-forming apparatus may be used, and longitudinal staggering of the plies produced by the breaking of transverse weakening lines along a series of continuous tubes, with welding by means of electrodes. Both bag ends may be similarly sealed, with a filling valve at one end.
Patent GB-1256970-A (GB)
IPC: C07D239/91
Filed: 1969-03-26
Abstract: 1,256,970. Quinazolinone derivatives. WALLACE & TIERNAN Inc. 26 March, 1969 [28 March, 1968], No. 15884/69. Heading C2C. Novel, therapeutic compounds I (including salts thereof) wherein X is halogen or CF 3 , Y is H, alkyl, phenylalkyl or acyl, R 1  is H, alkyl or phenylalkyl, R 2  is H, alkyl, alkoxy, alkylthio-alkyl, phenylthio - alkyl, phenylalkylthio - alkyl, 2,2,2-trifluoroethyl-thioalkyl, haloalkyl, cycloalkyl, cycloalkyl-alkyl, aryl or substituted aryl in which the substituent is OH, alkyl, alkoxy, halogen, CF 3 , SO 2 NH 2  or NH 2 , aralkyl or substituted aralkyl in which the aryl is phenyl or naphthyl and the aryl substituent is OH, alkoxy, alkyl, halogen, CF 3 , SO 2 NH 2  or amino, R 5  and R 8  are H, NH 2 , mono- or di-alkylamino, provided that when either R 5  or R 8  is H the other is not H, x, y and z signify H, OH, alkyl, alkoxy, alkoxy-alkyl, NH 2 , SO 2 NH 2 , CF 3  or halogen, and n is 0, 1, 2, 3 or 4, are obtained by reacting an amide II with an aldehyde, B 2 CHO, or with an acetal thereof; compounds I may also be obtained by reduction of the corresponding 5- and/or 8-nitro compounds. 5 - Chloro - 2 - methyl - 6 - nitro - acetanilide (prepared by the nitration of 5-chloro-2-methylacetanilide) is converted into 5-chloro-2-methyl- 6 - nitro - 4 - sulphamoyl - acetanilide utilizing chlorosulphonic acid and ammonia; oxidation of the latter acetanilide affords 5-chloro-2-carboxy - 6 - nitro - 4 - sulphamoyl - acetanilide and subsequent hydrolysis gives the corresponding amine; the amine reacts with phosgene to yield 6 - chloro - 5 - nitro - 7 - sulphamoyl isatoic anhydride which, in turn, reacts with o-toluidine to give 2 - amino - 4 - chloro - 3 - nitro - 5 - sulphamoyl - N - (o - toyl) - benzamide, which, in turn, reacts with 1,1-dimethoxy -ethane to afford 7 - chloro - 2 - methyl - 8 - nitro - 3 - o - tolyl - 6- sulphamoyl - 1,2,3,4 - tetrahydro - 4 - quinazolinone.
Patent GB-1257284-A (GB)
IPC: H01L21/208
Filed: 1970-03-26
Abstract: 1,257,284. Induction heating. SIEMENS A.G. 26 March, 1970 [29 March, 1969], No. 14718/70. Heading BIS. [Also in Division H2] Apparatus for the unsupported zone melting of a crystalline rod using an induction coil has the power to the coil fed into an evacuated treatment vessel via at least three concentric tubular conductors, these being numbered in order of increasing (or decreasing) size, the odd numbered tubes being electrically interconnected at each end and the even numbered tubes (if more than one) being similarly interconnected, this arrangement reducing electrical losses. The spaces between the tubes may be evacuated, filled with gas or preferably contain insulating material, and the outermost tube is  sealed to the vessel by sealing ring C, although able to move axially with respect to it. The embodiment shown has 5 conductors, 1, 2, 3, 4 and 5, numbers 1, 3 and 5 connected by D and E and F and G and members 2 and 4 by H and K. A further embodiment has coolant channels in the conductors (Fig. 4) and a practical form of the invention is also depicted (Fig. 3).
Patent GB-1258919-A (GB)
IPC: F16G11/02
Filed: 1968-12-23
Abstract: 1,258,919. Rope couplings. C.C.L. SYSTEMS Ltd. 23 Dec., 1969 [23 Dec., 1968], No. 61083/68. Heading D1T. The compressible studs 1 have a castellated outer formation 4, 5 such that when these studs are compressed onto a rope 3 within each stud, the bore of each stud 1 assumes a corrugated or sinusoidal formation that grips the rope 3; each stud having an externally screw-threaded end 6 that is screwed into an end fitting 10, 11. The end fittings may be pivoted together as at 12.
Patent GB-1259133-A (GB)
IPC: B41K3/36
Filed: 1969-01-09
Abstract: 1,259,133. Selective embossing. MINNESOTA MINING & MFG. CO. 9 Jan., 1969 [10 Jan., 1968], No. 1473/69. Heading B6F. A selective embossing tool includes an endless chain 18 of embossing dies. Each embossing die comprises a head portion 27 having a male or female embossing die formed on one face thereof, a bifurcated tail member for engagement with a selecting pinion 37, and a thin flexible laterally extending section (28), Fig. 4 (not shown), which may be joined to an adjacent die by a pin or dovetail joint, or may be integral with the adjacent die. Two chains 18, 19 may be provided, having co-operating female and male dies respectively, or a single chain (85), Fig. 6 (not shown) co-operating with a resilient anvil (86), or a pair of chains (87, 88), Fig. 7 (not shown), one formed with male dies and the other being of resilient material. Die selection is effected by means of a knob 13 having positive locations provided by engagement of a resilient post 33 with internal grooves, the knob 13 being keyed to the pinion 37. An indication of the die selected is provided by a window (15), Fig. 2 (not shown), further windows (16, 17) showing the positions of other dies on the chain or chains. Impression is effected by squeezing two body portions 11, 12 together, the body portions being pivoted at 56, so that an anvil 76 presses on the lower chain 19 to emboss an embossable tape 46 between the chains. The tape is stored in a roll or magazine 45, the chains describing an oval path around the magazine. The tape is fed by a drive roller 51 co-operating with an idler roller 52, the drive roller being advanced by a pawl 73 and ratchet 63 when the body portions are allowed to return to normal position under a spring 75. During impression action, a post 43 engages slots 42 in a collar 39 fixed to the knob 13 to hold the chains 18, 19 in place.
Patent GB-1264490-A (GB)
IPC: H01H33/66
Filed: 1969-05-13
Abstract: 1,264,490. Vacuum switches. INSTITUT PRUFFELD FUR ELEKTRISCHE HOCHLEISTUNGSTECHNIK. 13 May, 1969, No. 24339/69. Heading H1N. A vacuum switch has a coil 3 producing a magnetic field with both radial and axial components, which thus serves to rotate the arc and to reduce its voltage. The coil has the shape of a truncated cone, thus producing divergent lines of flux; it is embedded in cast resin 2 surrounding the envelope and is connected in series with the contacts 4, 5. In a modification (Fig. 2, not shown), the coil is made of flat strip wound to form a conical shield inside the envelope.
Patent GB-1289925-A (GB)
IPC: C21C1/00
Filed: 1971-04-19
Abstract: 1289925 Alloys for addition to cast iron COMPAGNIE PECHINEY 19 April 1971 [16 April 1970] 26748/71 Headings C7A and C7D A master alloy for the treatment of cast iron comprises:- Si 40-55% Mg 3-15% Ba 1À4-8À6% N such that the ratio Ba:N is from 5:1 to 50:1 and the ratio Mg:Ba being from 1:1 to 3:1 with balance Fe and less than 2À5% impurities. The alloy is added to molten cast iron at a temperature in the range 1460-1520C. about 10-15 mins before casting and the resultant cast iron contains spheroidal graphite in a ferrite matrix.
Patent GB-1290200-A (GB)
IPC: C08F26/02
Filed: 1970-01-13
Abstract: 1290200 Coatings BADISCHE ANILIN- & SODA-FABRIK AG 13 Jan 1970 [14 Jan 1969] 1537/70 Heading B2E [Also in Divisions C2 and C3] Wood, stone and concrete are coated with copolymers of compounds of formula wherein R<SP>1</SP> is an aliphatic, cycloaliphatic, araliphatic or aromatic radical and each R<SP>2</SP> is hydrogen or a aliphatic, cycloaliphatic, araliphatic or aromatic radical or any two radicals R<SP>2</SP> together with the carbon atoms to which they are attached form a carbocyclic ring system, with acrylates, for example methyl acrylate, methacrylates or styrene.