baber/WOPTO huggingface dataset:
Patent JP-2023546912-A (JP)
Title: Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレータ及び関連製品並びにその使用
IPC: A61K31/4706
Filed: 2021-10-20
Abstract: 一般にはＭＲＧＰＲＸ２若しくはＭＲＧＰＲＸ２オルソログを調節するための方法、又はより具体的には、構造（Ｉ）：JPEG2023546912000143.jpg63128又はその薬学的に許容される塩、異性体、水和物、溶媒和物、若しくは同位体を有する有効量の化合物を、それぞれ、それを必要とする対象へ投与することによって、ＭＲＧＰＲＸ２若しくはＭＲＧＰＲＸ２オルソログを接触させることにより、ＭＲＧＰＲＸ２若しくはＭＲＧＰＲＸ２オルソログ依存性状態を治療するための方法であって、式中、Ｗ、Ｚ、Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６、及びＲｘは、本明細書で定義した通りである、方法を提供する。そのような化合物を含有する医薬組成物、並びに当該化合物自体もまた提供される。
Patent JP-2023552286-A (JP)
Title: モジュール式の固定床バイオリアクターシステム及びその使用方法
IPC: C12M3/00
Filed: 2021-11-17
Abstract: 細胞培養用の固定床バイオリアクターシステムが提供される。該システムは、複数の細胞培養サブユニットを含み、各細胞培養サブユニットは、細胞培養基材を支持するための主面、入口、及び主面上に配置され、かつ入口と流体連通している複数の出口を備えた、分配プレートを含む。サブユニットは、分配プレートの主面上に配置された細胞培養基材も含む。該システムは、細胞、細胞培地、栄養素、及び試薬のうちの少なくとも１つを複数の細胞培養サブユニットに供給するための複数の投入ラインをさらに含み、該複数の投入ラインの各投入ラインは入口に流体接続されている。複数の出口は、複数の投入ラインからの細胞、細胞培地、栄養素、及び試薬のうちの少なくとも１つを細胞培養基材全体にわたって実質的に均一に分配するように構成される。
Patent JP-2023550822-A (JP)
Title: メソ多孔性・マクロ多孔性担体上の捕捉塊の存在中での有機金属不純物の捕捉方法
IPC: C10G45/10
Filed: 2021-11-18
Abstract: 本発明は、硫黄化合物およびオレフィンを含有しているガソリンタイプの炭化水素供給原料中の有機金属不純物を捕捉するための方法であって、前記供給原料を水素およびニッケルベースの活性相と、メソ細孔の二峰性分布を有しているメソ多孔性およびマクロ多孔性のアルミナ基質とを含んでいる捕捉塊と接触させ、ここで、径が２ｎｍ以上かつ１８ｎｍ未満であるメソ細孔の容積は、前記基質の全細孔容積の１０～３０容積％に相当し、径が１８ｎｍ以上かつ５０ｎｍ未満であるメソ細孔の容積は、前記基質の全細孔容積の３０～５０容積％に相当し、径が５０ｎｍ以上かつ８０００ｎｍ未満であるマクロ細孔の容積は、前記基質の全細孔容積の３０～５０容積％に相当する方法に関する。
Patent JP-2023554423-A (JP)
Title: 電池筐体用のハウジング、電池の筐体、電池及び電力消費装置
IPC: H01M50/209
Filed: 2022-06-02
Abstract: 本出願の実施例は、電池筐体用のハウジング、電池の筐体、電池及び電力消費装置を提供し、ハウジングの取り付けの技術分野に属する。ハウジングは、電池管理システムを収容するための本体と、本体に固定される取り付け部材とを含み、弾性部材が組み立てブラケットの制限で発生した反発力により、取り付け部材の組み立てブラケットにおける位置を固定し、さらにハウジングの組み立てブラケットにおける位置を固定する。ハウジングを取り付ける時、余分な部品を必要とせず、ハウジングを組み立て溝に押し込んで係止すればよく、取り付け工程が簡単で、組み立て効率が高く、手間も節約する。また、弾性部材は、組み立てブラケットの制限で反発力を発生させ、ハウジングが使用中に振動しても、この反発力は、振動によって発生した力を相殺できることで、ハウジングが組み立てブラケットで揺れることを回避でき、ハウジングの取り付けの安定性を向上させ、安全上の危険性の発生を回避する。
Patent JP-2024500122-A (JP)
Title: 分析物を検出する方法
IPC: G01N33/543
Filed: 2021-12-15
Abstract: 本発明は、試料中の分析物を検出する方法および該方法を実行するための装置を提供する。本発明の方法は以下の工程を含む。（ｉ）試料、レポーター試薬および予備活性化試薬を含む混合物を装置に提供する工程であって、前記装置が、光学要素および結合要素を有する基材を含み、前記光学要素および結合要素が前記基材の表面に結合されており、前記レポーター試薬が、電磁放射線の吸収により前記予備活性化試薬から反応性酸素種を生成することができ、前記光学要素が、前記反応性酸素種との反応により第１の光学状態から第２の光学状態に変化することができる前記工程、（ｉｉ）前記結合要素によって、前記レポーター試薬の一部が前記分析物の濃度に比例して前記基材の表面に結合できるようにする工程、（ｉｉｉ）前記レポーター試薬による吸収のために電磁放射線を前記装置に照射し、それによって前記基材上に前記第２の光学状態を有する光学要素の局所領域のセットを形成する工程であって、照射前に前記基材を重水素濃縮液と接触させ、かつ／または前記基材がその表面に重水素濃縮層を有する工程、（ｉｖ）前記基材上の前記第２の光学状態を有する局所領域のセットを検出する工程。
Patent JP-2024501853-A (JP)
Title: 水溶液からの混合金属イオンの回収
IPC: C22B3/26
Filed: 2021-12-30
Abstract: 本明細書に記載の選択的逆抽出技術を使用して有価金属イオンを分離することにより、リサイクルされた電子機器及び／又は電池に由来し、且つ混合金属イオンを含有する溶液からマンガン、コバルト、ニッケル及び／又はリチウムのいずれかなどの有価金属イオン種を回収する湿式精錬溶媒抽出プロセスが提供される。【選択図】図１
Patent JP-2024502479-A (JP)
Title: キメラ受容体療法
IPC: C12N15/113
Filed: 2022-01-10
Abstract: 免疫チェックポイントタンパク質の発現を阻害するｍｉＲＮＡをコードする天然に存在しないポリヌクレオチド。ポリヌクレオチドは、キメラ受容体、サイトカイン、及び／又は細胞タグを更にコードし得る。前述のポリヌクレオチドを含む、ベクター。前述のポリヌクレオチドを含む、修飾された免疫エフェクター細胞。前述のポリヌクレオチド及び／又は細胞を含む、組成物及びキット。疾患又は障害に罹患している対象を治療するための方法であって、その治療を必要とする対象に、前述の細胞を投与することを含む、方法。疾患又は障害の治療のための医薬の製造における前述の細胞の使用。対象における抗原の過剰発現と関連する疾患又は障害を検出するための方法。キメラ抗原受容体をコードするポリヌクレオチド又はそれを含む細胞の連続投与を含む、疾患又は障害を治療するための方法。【選択図】図１Ａ
Patent MX-2007002491-A (MX)
Title: Pharmaceutical use of graptopetalum and related plants.
Inventor: HSU SHIH-LAN
IPC: A61K35/00
Filed: 2005-08-29
Abstract: The present invention relates to compositions comprising Graptopetalum and uses thereof. Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalumis useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.
Patent MX-2007008470-A (MX)
Title: Finishing set for a floor covering and holder, as well as finishing profile, for a finishing set, and method for manufacturing a finishing profile and a skirting board.
Inventor: SCHACHT BENNY
IPC: E04F15/02
Filed: 2005-12-22
Abstract: Finishing profile for a floor covering, said profile at least consisting of a body formed by several portions (7-11-52), whereby two or more of these portions can be mutually separated or combined in function of the intended application, characterized in that the body is at least partially encased by means of a layer-shaped covering (46) which, in the non-separated condition or combined condition of at least two of said portions, extends or can extend at least over the transition between these portions.
Patent MX-2007010563-A (MX)
Title: PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS.
Inventor: JAESCHKE GEORG
IPC: C07D403/12
Filed: 2006-03-02
Abstract: The present invention is concerned with novel pyrazine 2-carboxyamide derivatives of the general formula (I) useful as metabotropic glutamate receptor antagonists: formula (I) wherein R<sup>1</sup>, R<sup>2</sup> and R<sup>3</sup> are as defined in the description and claims.
Patent MX-2007010694-A (MX)
Title: Method of providing a packaging laminate with an identification code, method of identifying a package, and package with identification code.
Inventor: INGVERT CLAES
IPC: B65D5/00
Filed: 2006-01-27
Abstract: In a method of providing a packaging laminate with an identification code (2) the packaging laminate is sub-jected to a magnetic field, thus magnetising a matrix (2) of magnetic domains (4) in the packaging laminate. Each magnetic domain (4) is made up of a number of the mag-netisable particles. A method of identifying a package (1) is also disclosed. The package (1) has walls (3) of a packaging laminate comprising magnetisable particles. The method comprises the steps of subjecting the packaging laminate to a magnetising magnetic field, thus magnetis-ing a matrix (2) of magnetic domains (4) in the packaging laminate, and detecting an emitted magnetic field emitted by the magnetic domains (4) in the matrix (2). A package (1) having an identification code (2) is also described.
Patent MX-2007011884-A (MX)
Title: Diagnostic test kits employing an internal calibration system.
Inventor: KAYLOR ROSANN MARIE MATTHEWS
IPC: G01N33/543
Filed: 2006-01-19
Abstract: A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy. calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.
Patent MX-2008001839-A (MX)
Title: Herbicide tolerant cotton plants and methods for identifying same.
Inventor: TROLINDER LINDA
IPC: C12N15/82
Filed: 2006-08-01
Abstract: The invention provides specific transgenic cotton plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the cotton genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.
Patent MX-2008006305-A (MX)
Title: The possibility of special lightening, insulating and reinforcing intermediate floor constructions.
Inventor: KEKANOVIC MILAN
IPC: E04B1/00
Filed: 2006-11-10
Abstract: The possibility of special lightening, insulating and reinforcing intermediate floor constructions enables fast building of semi-prefibraceted and prefabricated floor with complete insulation, bearing capacity and smaller price. Floor elements (1) and (15) are constructed to that already present steel space trusses can be placed in their channels, so that are hastened the building of intermediate floor constructions and makes them cheaper, too. They are minimum shorting at the ends and at the middle of beams, so the works below can be proceeding and the required working time is shorter. The intermediate floor construction is already insulating, so they are no need for insulating, which makes the construction cheaper and the required working time shorter. The plates (17) are enabling the increase of the height of the floor constructions, by tying two beams in the construction. Usage of distance elements (23) (35) and (48) protects the reinforcement in floor construction, so they are no need for corrosion protection.
Patent MX-2008010399-A (MX)
Title: Electronic ballast having adaptive frequency shifting.
Inventor: TAIPALE MARK S
IPC: H05B41/392
Filed: 2007-01-29
Abstract: An electronic ballast for driving a gas discharge lamp avoids mercury pumping in the lamp by adaptively changing an operating frequency of an inverter of the ballast when operating near high-end. The inverter of the ballast generates a high-frequency AC voltage, which is characterized by the operating frequency and an operating duty cycle. The ballast also comprises a resonant tank for coupling the high-frequency AC voltage to the lamp to generate a present lamp current through the lamp, and a current sense circuit for determining the magnitude of the present lamp current. A hybrid analog/digital control circuit controls both the operating frequency and the operating duty cycle of the inverter with closed-loop techniques. The control circuit adjusts the duty cycle of the inverter in response to a target lamp current and the present lamp current. To avoid mercury pumping, the control circuit attempts to maximize the duty cycle of the inverter when operating at high-end. Specifically, the control circuit adjusts the operating frequency of the inverter in response to the target lamp current signal, the duty cycle of the inverter, and a target duty cycle in order to drive the operating duty cycle toward the target duty cycle.
Patent MX-2008013173-A (MX)
Title: Arrangement for transmitting movement between, in particular, a vehicle door catch and lock.
Inventor: FLANDRINCK CHRISTIAN
IPC: E05B65/12
Filed: 2007-04-10
Abstract: The invention relates to a rotary output member such as a motor vehicle door catch and a rotary input member of a mechanism such as a motor vehicle door lock. This arrangement is of the type comprising a movement-transmitting device inserted between the two rotary members (18, 23) and comprising the transmission shaft the two ends of which, together with the rotary output and input members, form articulated universal joints allowing some degree of axial misalignment. Each end has the overall shape of a ball collaborating with a complementary rotary member part. The arrangement is characterized in that at least the ball (18) at the catch end of the transmission shaft (17) is a faceted ball (20), the number of facets of which is defined according to the angle (a) between the catch (13) and the lock. The invention can be used in motor vehicles.
Patent MX-2008014212-A (MX)
Title: Films with microcapsules.
Inventor: CATALFAMO VINCENZO
IPC: C11D3/50
Filed: 2007-05-07
Abstract: Articles comprising a functionalized substrate comprising at least two substantially planar water-soluble films carrying a coating of a functional composition, wherein the coating is between the two films, and wherein the functional composition comprises a microcapsule, are an effective means of dosing perfume or other actives to fabric during the laundering process.
Patent MX-2009002460-A (MX)
Title: Hybrid suppressor trna for vertebrate cells.
Inventor: NORMAN THEA
IPC: C12P21/06
Filed: 2007-09-07
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O- tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
Patent MX-2009010893-A (MX)
Title: Xanthine compounds having a positive allosteric gabab receptor modulator effect.
Inventor: HOLMQVIST SARA
IPC: A61P1/04
Filed: 2008-04-17
Abstract: The present invention relates to novel xanthine compounds of the general formula (I) wherein R1, R2, R3 and R4 are as defined, having a positive allosteric GABA Breceptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABA Bagonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS).
Patent MX-2009011091-A (MX)
Title: Video detection system and methods.
Inventor: CAVET RENE
IPC: H04N21/232
Filed: 2008-04-13
Abstract: A video detection system and method compares a queried video segment to one or more stored video samples. Each of the queried video segments and stored video samples can be represented by respective digital image sets. A first and second comparison comprises comparing a set of low and high resolution temporal and spatial statistical moments in a COLOR9 space, and eliminating file digital image sets that do not match the queried digital image set. A third comparison generates a set of matching files by comparing a set of wavelet transform coefficients in a COLOR9 space. RGB bit- wise registration and comparison of one or more subframes of specific frames in the queried digital image set to a corresponding set of matching file subframes determines queried subframe changes. In the event of a change in a queried subframe, the changed subframe is added to the set of matching file subframes.
Patent MX-2009011150-A (MX)
Title: Bottom of a mould for a mould for producing thermoplastic containers, and moulding device comprising at least one mould provided with such a bottom.
Inventor: BOUKOBZA MICHEL
IPC: B65D1/00
Filed: 2009-01-05
Abstract: The invention relates to a bottom of a mould (13) for a mould for producing containers, especially bottles, by blow moulding or blow drawing, said containers having a body and a bottom (14) of a container, comprising a peripheral base (15) in the shape of a crown, which is connected on the inside to a central area (16) forming an arch consisting of a plurality of radiating impressions (17) alternating with a plurality of radiating projections which are distributed in an angular and equidistant manner about a central axis (Y) of the bottom (14) of the container. For the moulding of the central area (16) of the bottom (14) of the container, the bottom (13) of the mould comprises: a plurality of radiating projecting branches (19) distributed in an angular and equidistant manner, and extending approximatively radially to the axis (X) of the bottom of the mould; a central core (20) comprising a lateral wall (21) to which the branches (19) are connected; and in-between sections (22) forming cores of angular sectors regularly separating said branches from each other. The bottom (13) of the mould is characterised in that each radiating projecting branch (19) has an upper part (23) in the form of an inclined platform which descends from the centre towards the periphery with at least two points (24, 25) of inflection of the curve.
Patent MX-2009012403-A (MX)
Title: Bolting system for points changing in railways.
Inventor: ALBISUA ASPIAZU VICENTE
IPC: B61L5/02
Filed: 2008-05-13
Abstract: The invention comprises two bolt bodies (1, 2, 32, 33) linked by an intermediate bar (5, 37) and with one of them connected to an external actuating mechanism, arranged transversely to the railway and suspended from the respective shoe (6, 35) of the counterpoint (4, 36). The needles (3, 34) are moved by means of respective sliders (14, 43) which slide within a box (9, 39) fastened to the bolt bodies (1, 2, 32, 33). Bars (15, 38) slide in each of the sliders (14, 43) and the bars are lockable (15, 38) with the sliders (14, 43) and the sliders (14, 43) with the boxes (9, 39). The bar (38) has two wide rabbets (48, 49) each for housing a roller (50, 51) which move in each of the transversal sheaves (52, 53) of the slider (43). These rollers (50, 51) interact with the semicylindrical rabbets (54, 55) of the box (39). The relative position of the rollers (50, 51) controls whether the slider (43) is dragged or not.
Patent MX-2010002286-A (MX)
Title: Method and system using reloadable portable consumer devices.
Inventor: ANTOO NIZAM
IPC: G06Q40/00
Filed: 2008-08-26
Abstract: A method is disclosed. The method includes providing tender at an automatic teller machine (ATM), where the automatic teller machine is in operative communication with a payment processing network. The automatic teller machine sends a transaction authorization request message to an issuer of a portable consumer device, and the issuer authorizes or does not authorize the transaction authorization request message.
Patent MX-2010008375-A (MX)
Title: Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands.
Inventor: HUDKINS ROBERT L
IPC: H01R13/10
Filed: 2009-01-30
Abstract: The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
Patent MX-2010011514-A (MX)
Title: Methods, systems, and bottom hole assemblies including reamer with varying effective back rake.
Inventor: MEISTER MATTHIAS
IPC: E21B10/26
Filed: 2009-04-23
Abstract: Reamer bits have cutters with different effective back rake angles. Drilling systems include a pilot bit and a reamer bit, wherein cutters in shoulder regions of the reamer bit have a greater average effective back rake angle than cutters in shoulder regions of the pilot bit. Methods of drilling wellbores include drilling a bore with a pilot bit, and reaming the bore with a reamer bit having cutters in shoulder regions of the reamer bit that have an average effective back rake angle greater than that of cutters in shoulder regions of the pilot bit. Methods of forming drilling systems include attaching pilot and reamer bits to a drill string, and positioning cutters in shoulder regions of the reamer bit to have an average effective back rake angle greater than that of cutters in shoulder regions of the pilot bit.
Patent MX-2010012194-A (MX)
Title: Improved check valve flap for fluid injector.
Inventor: BUSHMAN RICHARD PAUL
IPC: A61C17/06
Filed: 2009-06-25
Abstract: A backflow-prevention system that substantially prevents contaminant backflow at a treatment site. The system includes a fluid ejector tube for insertion into the patient's mouth and a backflow prevention device that receives fluid from the fluid ejector tube. The backflow prevention device includes an internally positioned valve member. The valve member limits contaminant backflow. The valve member is movable between open and closed positions based on a vacuum pressure condition in the system.
Patent MX-2010012983-A (MX)
Title: In-mold punch apparatus and methods.
Inventor: KOLBET RANDALL A
IPC: B29C48/13
Filed: 2009-05-27
Abstract: A mold (19) is provided for forming a continuously-extruded parison into a corrugated pipe. The mold includes a mold housing having a plurality of bores, a mold cavity having a plurality of annular corrugations (26), and a plurality of punches (30). Each punch is disposed in one of the bores and aligned with one of the annular corrugations of the mold cavity. Each punch is also configured to form an aperture in a corrugation of a corrugated pipe in the mold. A continuous extrusion blow molding system and a method are also provided for forming a hollow plastic product and punching a continuously-extruded, blow molded product before it is released from a mold.
Patent MX-2011001906-A (MX)
Title: Fibrous structures and methods for making same.
Inventor: MANIFOLD JOHN ALLEN
IPC: D21H27/00
Filed: 2009-08-18
Abstract: Fibrous structure that exhibit a Free Fiber End Count of greater than 100 in the range of free fiber end lengths of from about 0.1 mm to about 0.25 mm as determined by the Free Fiber End Test Method, sanitary tissue products employing same and methods for making same are provided.
Patent MX-2011005480-A (MX)
Title: Stem cell for therapeutic use which is derived from human monocyte, and method for inducing same.
Inventor: ISHIYAMA HIRONOBU
IPC: A61K35/12
Filed: 2009-11-19
Abstract: A stem cell produced by culturing a monocyte in the presence of (i) M-CSF and (ii) at least one component selected from a group consisting of a ganglioside and a water-soluble plant extract to dedifferentiate the monocyte; a therapeutic agent for diseases associated with the damage of cells, tissues or organs; a cellular therapeutic agent; a method for producing a stem cell; a culture medium for inducing the dedifferentiation of a monocyte; a dedifferentiation-inducing agent; a kit for cellular therapy, or a kit for producing dedifferentiated cells; and a pharmaceutical composition.
Patent MX-2011013435-A (MX)
Title: Dispenser.
Inventor: LIND MATS
IPC: A47K10/42
Filed: 2009-06-30
Abstract: A dispenser comprises a housing (4) and a door pivotally attached to the housing (4) via a substantially vertically arranged hinge. The housing (4) comprises a hinge wall (16), an upper end wall (10), a substantially vertical wall (12) and a lower end wall (14). The walls (10, 12, 14, 16) define an edge (36) delimiting a lateral charge opening (38). The housing (4) is provided with a dispensing opening (32) at the lower end wall (14). The door comprises an essentially vertical portion, a free end opposite the hinge and a door rim at lest partly adjacent the edge (36) of the housing (4) when the door is in a closed position. The (Edge 36) of the housing (4) has a free edge portion (42) extending along the upper end wall (10), the substantially vertical wall (12) and the lower end wall (14). The free edge portion (42) comprises a guiding element (44) for co-operation with a region of the door rim during pivoting of the door towards the closed position and for vertically positioning the free end of the door. The guiding element (44) is provided with an upwardly inclined surface (56).
Patent MX-2012000487-A (MX)
Title: Azabicyclo compound and salt thereof.
Inventor: KITADE MAKOTO
IPC: A61K31/437
Filed: 2010-07-09
Abstract: Disclosed is a novel azabicyclo compound which has both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by general formula (I) or a salt thereof. (In the formula, X1 represents CH or N; one of X2, X3 and X4 represents N, and the others respectively represent CH; one or two of Y1, Y2, Y3 and Y4 respectively represent C-R4, and the others may be the same or different and respectively represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group that has 1-4 heteroatoms selected from among N, S and O; R2 represents an alkyl group having 1-6 carbon atoms, or the like; and R3 and R4 respectively represent -CO-R5 or the like.).
Patent MX-2012001695-A (MX)
Title: Bicyclic heteroaryl inhibitors of pde4.
Inventor: THOMAS DAVID J
IPC: C07D401/14
Filed: 2010-08-19
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.