baber/WOPTO huggingface dataset:
Patent CA-2378373-A1 (CA)
Title: Production of rhpbgd and new therapeutic methods for treating patients with acute intermittent porphyria (aip) and other porphyric diseases
Inventor: GELLERFORS PAR
IPC: A61K35/76
Filed: 2000-07-27
Abstract: A method for production of rhPBGD in high scale and use of rhPBGD in a method for treatment or prophylaxis of disease caused by deficiency, in a subject, of an enzyme belonging to the heme biosynthetic pathway. The method comprising administering, to the subject, an effective amount of one or more catalyst which is said enzyme or an enzymatically equivalent part or analogue thereof prefreable in combination with a gene therapy of a mutation related to the catalyst. The disease is selected from the group consisting of acute intermittent porphyria (AIP), ALA deficiency porphyria (ADP), Porphyria cutanea tarda (PCT), Hereditary coproporphyria (HCP), Harderoporphyria (HDP), Variegata porphyria (VP), Congenital erythropoietic porphyria (CEP), Erythropoietic protoporphyria (EPP), and Hepatoerythropoietic porphyria (HEP).  The catalyst is one or more enzymes selected from the group consisting of delta-aminolevulininic acid synthetase, delta-aminovulinic acid dehydratase (ALAD), porphobilinogen deaminase (PBGD), uroporphyrinogen III cosythetase, uroporphyrinogen decarboxylase, coproporphyrinogen oxidase, protoporphyrinogen oxidase, and ferrochelatase, or an enzymatically equivalent part or analogue therof. In addition the invention relates to the use of rhPBGD. The invention also relates to an expression plasmid pExp1-M2-BB (seq. ID No.1) and to use of a DNA fragment, the EcoR I - Hind III linear fragment (seq. ID No. 2), used for transformation in the hemC disruption strategy for production of rhPBGD  expressed in E. coli..
Patent CA-2380808-A1 (CA)
Inventor: SCHNITZER MARK J
IPC: G02B6/32
Filed: 2002-04-08
Abstract: A mode converter includes first and second optical waveguides and a GRIN fiber lens. The GRIN fiber lens is attached to both the first and the second waveguides.
Patent CA-2382174-A1 (CA)
Inventor: BONNET DOMINIQUE
IPC: C07K1/00
Filed: 2000-08-18
Abstract: The invention concerns a method for coupling a peptide with at least a compound A, of the non-peptide type, bearing a function selected among the group consisting of carboxylic acid functions and alcohol functions. The invention is characterised in that said coupling comprises a step which consists in producing, in solution, a hydrazide bond between said peptide and said compound A. The invention also concerns modified peptides essentially formed by a peptide bound by a hydrazide bond to at least a compound A as defined above, such as a lipid, a sugar, an alcohol or a fluorescent marker, as well as the uses of said modified peptides. The invention further concerns the use of N,N'-tri(Boc)hydrazinoacetic and N,N'-di(Boc)hydrazinoacetic acids to functionalize a peptide with a .alpha.-hydrazinoacetic group.
Patent CA-2382565-A1 (CA)
Inventor: ANDREWS TIMOTHY
IPC: G02B6/35
Filed: 2000-08-31
Abstract: A system for coupling up one or more light sources to one or more destinations is provided. Under the present invention, the transmission efficiency from a light source to a destination is optimized regularly on an automatic basis by monitoring the intensity of the light transmitted. In a preferred embodiment, the system includes a source fiberoptic cable for bundling up light emitted from a multitude of light sources, a destination fiberoptic cable for receiving light transmitted from the source fiberoptic cable, a motorized positioning stage for aligning the source and the destination fiberoptic cables, and a feedback servo control for adjusting the motorized positioning stage to accurately align the source and the destination fiberoptic cables based on the intensity of the light transmitted by the source fiberoptic cable. In operation, the intensity of the light transmitted by the source fiberoptic cable is detected by the feedback servo control. Based on the intensity reading, the feedback servo control selectively directs the motorized positioning stage to align the source and the destination fiberoptic cables in an optimal position to improve transmission efficiency.
Patent CA-2383672-A1 (CA)
Inventor: COLLIER FOREST MICHAEL
IPC: E01D19/02
Filed: 2002-04-26
Abstract: A bridge pillar debris deflection apparatus (10), which attaches to a pillar supporting a structure located on a water way, such as a river or ocean. The apparatus (10) deflects debris to maintain the pillar clear from any unwanted build-up of rubbish. The apparatus utilizes at least one finned cylinder (30) that is rotatably held in place in front of a pillar (50) with an upper attachment bracket (26) and a lower attachment bracket (28). The cylinder is rotated by the force of the water impinging on a multiplicity of fins (44) extending from the outer surface of the cylinder to deflect the debris and prevent any accumulation. An axle (38) is positioned between the brackets and extends through the cylinder in the preferred embodiment. Any number of cylinders may be used in tandem, according to the need and environmental conditions. A variety of different brackets may be employed to attach the apparatus to a pillar or buttress, such as attaching plates (23), circumferencial bands (22), sliding brackets and even roller-equipped, movable brackets (46) that glide up and down the pillar.
Patent CA-2385470-A1 (CA)
Title: Message piggybacking during transport medium congestion
Inventor: MALOY JON
IPC: H04L47/32
Filed: 2000-08-25
Abstract: A computer (30(1)) detects congestion (50, 80) on a network transport medium (32) and in response thereto refrains from sending any packets containing messages. These to be transmitted messages are instead stored (56, 84) by the computer in memory (40). In one embodiment, each message addressed to the same destination addressee computer is stored (84) in a common buffer (38), with a different buffer being allocated to each identified destination addressee computer (30(2) and 30(3)) for the to be transmitted messages. In another embodiment, each such message is encapsulated (54) into a single packet (36) that is stored (56) in the reserved portion. When the congestion condition on the transport medium subsides (58, 86), the one or more messages stored within a given buffer are retrieved from memory and encapsulated (104) within a single packet (36) addressed to the destination addressee computer associated with that given buffer. Alternatively, the stored single packet is retrieved from memory. That single packet is then sent (76, 106) over the transport medium to the identified destination addressee computer.
Patent CA-2386953-A1 (CA)
Inventor: WEST HARRY R
IPC: F24D3/08
Filed: 2002-05-17
Abstract: A combination domestic hot water and space heating system has an instantaneous domestic hot water heat exchanger and a low mass boiler-type heat generator connected in a series by a boiler water flow circuit containing a circulating pump. The boiler-type heat generator has an internal reservoir containing between 10 and 20 U.S. gallons of boiler water, which is sufficient to enable the heat exchanger to supply normal short term demand, yet avoid excessive downtime thermal losses.  A three-way diverter valve in the flow circuit diverts boiler water to a second heat exchanger in an air handler unit for space heating. Priority is given to domestic water heatina.
Patent CA-2388391-A1 (CA)
Inventor: DALLAS L MURRAY
IPC: E21B33/072
Filed: 2002-05-31
Abstract: A reciprocating lubricator includes a lubricator base, a lubricator tube connected at the top to a lubricator head and inserted through a packing in the lubricator base to provide a sealable chamber adapted to accommodate a downhole tool to be inserted into a wellbore against well fluid pressure. The chamber in the lubricator tube is sealed using equipment mounted to the lubricator head. Injectors interconnecting the lubricator base and the lubricator head reciprocate the lubricator tube through the lubricator base. When a downhole tool is inserted into the wellbore, the lubricator head rests against the lubricator base to provide a low, safe and stable position for operation of the equipment mounted to the top of the lubricator head.
Patent CA-2391143-A1 (CA)
Title: Process for producing .alpha.-olefin
Inventor: FUJI JUNICHI
IPC: C07C1/20
Filed: 2002-06-21
Abstract: A production process for .alpha.-olefins making use of elimination reaction of a primary alcohol or an ether is characterized by use of an alumina catalyst in the presence of an amine. The production process for .alpha. -olefins according to the present invention can yield an .alpha.-olefin at a high proportion with respect to the entire olefin products and can maintain the reactivity of the catalyst and selectivity of the products for a prolonged time. In the process, unreacted material and ether intermediate by-product produced in the process can be used in the reaction with the same catalyst. This allows industrially and environmentally favorable production process of .alpha.-olefins.
Patent CA-2393478-A1 (CA)
Title: Oxidation dye composition for keratinic fibres containing a thickening polymer with an ether plastic skeleton
Inventor: ALLARD DELPHINE
IPC: A61K8/81
Filed: 2000-11-10
Abstract: The invention relates to an oxidation dye composition for keratinic fibres, especially for human keratinic fibres such as hair, containing at least one oxidation dye and a thickening polymer with a plastic ether skeleton, in a medium which is suitable for dyeing. The invention also relates to the dyeing method and devices for using the inventive composition.
Patent CA-2394683-A1 (CA)
Title: Multiple copy capability for network backup systems
Inventor: VAITZBLIT LEV
IPC: G06F12/00
Filed: 2000-12-13
Abstract: A method and apparatus for providing a multiple copy file backup system (210) is disclosed in which files that have been previously backed up by a first user are to be backed up by different users. The first instance of backing up a file results in storing the file and user in an entry in 238808-1a file data table (212). For other users needing to backup the same file, the contents of the file are copied from the first location into a second location within the file backup storage system (210). The file backup system creates two new entries in the file data table (212). In one entry the file stored in the second location is associated with a User-Pool that allows sharing the file contents among the users. The second and subsequent entries in the file data table (212) will be created as the subsequent users desiring to backup the file. These entries will indicate that the file is provided by the User-Pool and the necessary data will be copied from the User-Pool entry to properly associate the user with the file contents.
Patent CA-2396212-A1 (CA)
Title: Recombinant antibodies to human interleukin-1 beta
Inventor: GRAM HERMANN
IPC: A61P37/06
Filed: 2001-01-19
Abstract: An IL-1.beta. binding molecule, in particular an antibody to human IL-1.beta., especially a human antibody to human IL-1.beta. is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e. g, osteoarthritis, osteoporosis and other inflammatory arthritides.
Patent CA-2397132-A1 (CA)
Title: Optical disk and methods for recording and reproducing essencial information of optical disc
Inventor: YOON DU-SEOP
IPC: G11B7/24
Filed: 2002-08-08
Abstract: An optical disc and methods for recording essential information in and reproducing essential information from an optical disc are provided. The optical disc includes as a pattern of crystalline and amorphous marks storing essential information. The essential information recording method involves: heating an amorphous recording layer above the temperature of crystallization by radiating a beam according to a photoelectrically converted signal; and slowly cooling the heated recording layer to the temperature of crystallization or below to form a pattern of crystalline and amorphous marks. The essential information reproducing method involves: radiating a beam onto a pattern of crystalline and amorphous marks in which essential information of the optical disc is recorded; receiving the beam reflected from the pattern of crystalline and amorphous marks and photoelectrically converting the received beam to detect a signal; filtering the detected signal through a high-pass filter; and reproducing the essential information of the optical disc from the filtered signal. Essential information can be recorded in a recordable optical disc by phase change using an existing disc initializing apparatus after deposition of a recording layer and before initialization of the optical disc. Therefore, an additional recording apparatus and process is not necessary, and no damage caused by a high energy of laser occurs in the optical disc.
Patent CA-2398590-A1 (CA)
Title: Cells for drug discovery
Inventor: CASE CASEY
IPC: G01N33/68
Filed: 2001-02-08
Abstract: Disclosed herein are compositions and methods useful in screening a compound  for its interaction and/or effect with a molecular target and/or cellular process. The invention is based on the construction of fusion proteins betwe en a zinc finger protein designed to recognize a specific promoter and a transcription repressor or activator. Claimed are methods for the screening of substances capable of interacting with a specific cellular target or modulating a cellular pathway, involving cells stably transfected with, and expressing, the fusion protein.
Patent CA-2399433-A1 (CA)
Title: Retractile grab device for the recovery of blocks submerged in a marine environment
Inventor: TORRES SAMPER RAFAEL
IPC: B66C3/02
Filed: 2002-08-22
Abstract: A retractile grab device for extracting and recovering submerged concrete blocks that form part of the protection structure at marine harbours and docks, associated with a crane or similar driving means that supports it and from which the operating tasks are performed, of mechanicals constitution, capable of executing a prehensile movement between its claw elements, whereby it takes firm hold of one of such blocks, raising it and depositing it optionally at any chosen place.
Patent CA-2399815-A1 (CA)
Inventor: BLIESNER WAYNE T
IPC: F02G1/057
Filed: 2000-06-12
Abstract: A Stirling engine which uses a dual pressure shell surrounding the high pressure and temperature engine components. Space between the shells is filled with an incompressible and insulating liquid material, such as a liquid salt.  The liquid may have a filler material to prevent excessive movement. The liquid provides a time varying pressure field, driven by the pressure variations in the Stirling engine working fluid, which cancels the pressure differential on heat transfer tubing. A continuous heat extraction burner reduces flame temperature and nitrous oxide emissions from the burner. The combination described provides a Stirling engine that operates at significantly higher temperatures and pressures relative to existing technology.
Patent CA-2400816-A1 (CA)
Inventor: DEMARET JEAN-POL
IPC: C09D133/26
Filed: 2001-02-23
Abstract: L'invention concerne un polymère filmogène préparé par polymérisation de: entre 4 et 50 mol % d'unités monomères A sélectionnées dans le groupe comprenant les esters trialkylsilyles d'un acide carboxylique éthyléniquement instaturé, et des mélanges de ces unités; entre 5 et 45 mol % d'unités monomères B sélectionnées dans le groupe comprenant les N-vinyl lactame monomères de formule générale CH2=CH-NR'''''-CO-R'|, les N-vinyl amides de formule générale CH2=CH-N-CO-R'', les monomères de formule générale CH2=CR'''-COO-R''''-NR'''''-CO-R'|, les monomères de formule générale CH2=CR'''-COO-R''''-N-CO-R'', 2-pyrrolidone-1-isoprényl kétone, et des mélanges de ces produits, R' représentant un radical n-alkylidène présentant 2 à 8 atomes de carbone, R'' étant sélectionné dans le groupe comprenant les radicaux alkyle, cycloalkyle, aryle, alkylaryle et arylalkyle présentant 18 atomes de carbone au maximum, R''' représentant H ou CH3, R'''' représentant un radical n-alkylidène présentant 1 à 8 atomes de carbone, R''''' représentant H ou R'', le reste des unités monomères étant des unités monomères C sélectionnées dans le groupe comprenant les esters d'acides carboxyliques éthyléniquement insaturés avec des alcools en C1-C18, styrène, styrène alpha-méthyl, toluènes vinyliques et des mélanges des produits précités. On prépare des peintures antisalissures possédant des propriétés autopolissantes dans l'eau de mer et dans l'eau douce et renfermant comme composants essentiels des polymères filmogènes et des agents antisalissures.
Patent CA-2401477-A1 (CA)
Title: Multibeam laser light source with variable source spacing for setting images on printing forms
Inventor: BEIER BERNARD
IPC: B41J2/45
Filed: 2002-09-04
Abstract: A description is given of a multibeam laser light source (10) with a number of preferably individual driveable laser light sources (12), which are arranged in an array, said light source (10) being distinguished by the fact that the spacing (130) of the light beam emitted by a first laser light source (12) from a light beam emitted by a second laser light source (12) can be varied by varying the pump energy distribution through the resonator of the first laser light source (12). A number of mutually insulated contacts (112) for current injection into each resonator is provided, so that a shift in the active region of the laser light source (12) at right angles to the emission direction is achieved by varying the driving of the contacts (112). The multibeam laser light source can be used with particular advantage in an imagesetting device for image carriers, in particular printing forms.
Patent CA-2403487-A1 (CA)
Inventor: RICHMOND MIKE
IPC: B65D81/32
Filed: 2001-07-03
Abstract: The invention discloses a method and an apparatus for a food container which includes an inner member (200) (which can be a cup or a bottle) for holding a particulate food; an outer member (100) (which can be a second cup or a second bottle) adapted to receive the inner member (200), with a space between the inner and the outer members (200, 100), for a liquid food; where the inner member (200) interlocks with the outer member (100) and openings (230) are provided for the discharge of the liquid food; and the particulate food and the liquid food can be consumed simultaneously by tilting the container towards the mouth of the user to discharge or withdraw particulate food from the inner member (200) and liquid food from the outer member (100) through the aperture (230).
Patent CA-2403822-A1 (CA)
Title: Systems for evaluating the urethra and the periurethral tissues
Inventor: ATALAR ERGIN
IPC: G01R33/34
Filed: 2001-04-02
Abstract: The present invention provides systems for the evaluation of the urethra and periurethral tissues using an MRI coil adapted for insertion into the male, female or paediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a decoupling circuit and a balun circuit. The interface circuit may also be in electrical communication with a MRI machine
Patent CA-2405564-A1 (CA)
Inventor: WITWAR HELMUT
IPC: A62B3/00
Filed: 2001-04-07
Abstract: The invention relates to a system for ensuring evacuation and rescue from the effects of smoke, heat and pollutants in areas with long evacuation routes, such as mining installations, underground transport systems, or similar. Said system takes advantage of the characteristics of a mist of water, which is generated by misting means, in such a way that the air lying in the area below the layer of fumes can be respired for a long period of time and its clarity can at least be maintained, so that the direction of evacuation remains visible. According to the invention, the sprinkler nozzles (3), which generate the mist, are fixed to sprinkler arches (2) that are positioned along the entire length of the area and/or its evacuation routes, one behind the other, transversally to the direction of evacuation, following the clearance contours of the area and/or the evacuation routes. The arch-type arrangement of the sprinkler nozzles (3) over the entire length of the areas and evacuation routes divides the structural installations into sections, which do not impede the basic air flow (6) present in the installation, in such a way that the smoke or pollutant flow is not accumulated by the mist that is produced.
Patent CA-2405797-A1 (CA)
Title: Gauging driving efficiency
Inventor: WEISMAN MILLER S II
IPC: B60W40/09
Filed: 2001-05-04
Abstract: An efficiency gauge may be used for controlling an automotive vehicle. At least one vehicle parameter (200) is sampled during vehicle operation and at least one measure of driving efficiency (210) is determined from the sampled vehicle parameters. Efficiency measurements may include determining an estimate of kinetic energy lost. One such estimate is the sampled braking velocity cost (208) found based on the difference of the squares of the last two vehicle velocities if the vehicle has decelerated and braking has occured.
Patent CA-2406391-A1 (CA)
Title: Normalized nucleic acid libraries and methods of production thereof
Inventor: LI WU-BO
IPC: C12Q1/68
Filed: 1998-09-24
Abstract: The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced.  The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods.
Patent CA-2407041-A1 (CA)
Title: Recuperation d'espace memoire
Inventor: HAYWARD ANDREW
IPC: G06F12/02
Filed: 2001-03-28
Abstract: L'invention concerne un récupérateur d'espace mémoire qui, à l'aide de pointeurs internes, maintient une structure d'arbre comprenant une multiplicité de noeuds liés (40-52), chaque noeud représentant une affectation mémoire (a g). Pour chaque pointeur (P) interne en cours d'utilisation connu, une recherche est effectué dans l'arbre pour permettre de déterminer l'affectation mémoire vers laquelle le pointeur est dirigé. Ladite affectation mémoire est notée comme étant indisponible pour la récupération d'espace mémoire. Une fois que tous les pointeurs en cours d'utilisation disponibles ont été localisés, le système libère les affectations mémoire qui n'avaient pas été notées comme étant indisponibles pour la récupération d'espace mémoire. De préférence, l'arbre est un arbre AVL. Le procédé est applicable à tous les schémas d'affectation mémoire, sans contraintes quant à la taille des affectations mémoire ou quant à leurs positions en mémoire. L'invention concerne en outre un procédé pour la récupération d'espace mémoire et un système d'exploitation comprenant un récupérateur d'espace mémoire.