Patent DE-102006042191-A1 (DE)
Title: Purifying radium-226, useful to prepare actinium-225, comprises eluting radium from a quality material, separating chemically similar elements by extraction chromatography, and recovering, pooling and concentrating the radium fraction
Inventor: KABAI EVA
IPC: C22B60/00
Filed: 2006-09-08
Abstract: Purifying radium-226 ( 2> 2> 6>Ra), for preparing actinium-225 from radioactive sources, comprises detecting the quality of (Ra) material; eluting (Ra) with a mineral acid; separating chemically similar elements e.g. barium by extraction chromatography, where extraction chromatography is carried out on a solid support material having an extractant coated system comprising icosahydro-5,8,11,16,19,22-hexaoxa-dibenzo[a,j]cyclooctadecene compound (I) in an alcohol compound (II) using e.g. nitric acid as a mobile phase; recovering and pooling Ra-fractions; and concentrating the purified Ra-fraction. Method for the purification of radium ( 2> 2> 6>Ra), for the target preparation for actinium ( 2> 2> 5>Ac) production from radioactive sources, comprises (a) detecting the quality of (Ra) material to be purified; (b) eluting (Ra) with a mineral acid from its storage vessel at least one time; (c) separating chemically similar elements including barium, strontium and lead from (Ra) by extraction chromatography, where extraction chromatography is carried out on a solid support material having an extractant coated system comprising at least icosahydro-5,8,11,16,19,22-hexaoxa-dibenzo[a,j]cyclooctadecene compound of formula (I) in at least an alcohol compound of formula (R 1> 0>-OH) (II), where nitric acid or hydrochloric acid is used as a mobile phase; (d) recovering (Ra) from the fractions, where barium and strontium are contained in fractions with higher retention time and lead is retained on the extractant system; (e) pooling (Ra) fractions; and (f) concentrating the purified Ra-containing fractions. R 8>, R 9> : H, 1-6C alkyl or tert-butyl; and R 1> 0> : 4-12C alkyl. An independent claim is included for a method for recycling radium ( 2> 2> 6>Ra), for target preparation of actinium ( 2> 2> 5>Ac) from radium source irradiated with accelerated protons (p,2n) after separating actinium, comprising (a1) detecting the quality of a Ra-containing solution to be purified and providing in a mineral acid solution; (b1) concentrating the Ra-containing solution by evaporation; (c1) removing trace amount of organic compounds using a prefilter column, which is an inert solid support material; (d1) separating (Ra) from the main chemical contaminants by cation exchange chromatography, which is carried out on a cation exchanger, preferably on an acidic macroporous cation exchanger; (e1) washing the cation exchange resin with low molar mineral acid to remove the main chemical contaminants; (f1) eluting (Ra) from the cation exchange resin with high molar mineral acid, where the fractions still contain chemically similar elements including barium and strontium; (g1) pooling and concentrating the partially purified Ra-fractions; (h1) subjecting the partially purified Ra-containing fractions to extraction chromatography, which is carried out on a solid support material having an extractant coated system comprising (I) in (II), where nitric acid or hydrochloric acid is used as a mobile phase; (i1) recovering (Ra) from the fractions, where barium and strontium are contained in fractions with higher retention time and carrying out steps (e) and (f). [Image] ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : None given.