baber/WOPTO huggingface dataset:
Patent MA-38457-A1 (MA)
Title: Composés à base de 1,3-oxazin-2-amine fusionnée avec du cyclopropyle perfluoré utilisables en tant qu'inhibiteurs de la bêta-sécrétase et leurs procédés d'utilisation
Inventor: QIAN WENYUAN
IPC: C07D491/048
Filed: 2014-03-06
Abstract: La présente invention concerne des composés de 1,3-oxazin-2-amine fusionnée avec du cyclopropyle perfluoré, utilisables en tant qu'inhibiteurs de la bêta-sécrétase et leurs procédés d'utilisation. La présente invention concerne donc une classe inédite de composés pouvant être utilisés en vue de la modulation de l'activité d'une enzyme, la bêta-sécrétase (bace). Lesdits composés sont représentés par la formule générale i : [formule a inserer ici], dans laquelle les variables a4, a5, a6, a8, chacun des ra, rb, r1, r2, r3 et r7 de la formule i sont chacun tels que définis ici. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et l'utilisation desdits composés et compositions en vue du traitement d'affections et/ou d'états pathologiques associés à la formation et au dépôt de plaques bêta-amyloïde, résultant de l'activité biologique de la bace. Lesdites affections à médiation par la bace comprennent, par exemple, la maladie d'alzheimer, les déficits cognitifs, les troubles cognitifs, la schizophrénie et d'autres affections touchant le système nerveux central. L'invention concerne, en outre, des composés de formule ii et iii et leurs modes de réalisation avec leurs sous-formules, des intermédiaires et des procédés de préparation des composés selon l'invention.
Patent MA-39533-A1 (MA)
Title: Composés, composition pharmaceutique et leur utilisation dans le traitement de maladies neurodégénératives
Inventor: MELNYK PATRICIA
IPC: C07D209/08
Filed: 2015-06-15
Abstract: L'invention concerne de nouveaux composés de formule (i), des sels ou des solvates pharmaceutiquement acceptables de ceux-ci, et leur utilisation.
Patent MA-44803-A1 (MA)
Title: Systèmes et procédés d'élimination de fluide d'un plateau dans un module de culture à la chaîne
Inventor: MILLAR GARY BRET
IPC: A01G31/02
Filed: 2018-05-21
Abstract: Cette invention concerne un système d'élimination de fluide pour un module de culture à la chaîne. Le système d'élimination de fluide comprend un rail, un chariot configuré pour se déplacer sur le rail, un collecteur d'élimination de fluide disposé sur le rail, et un dispositif de commande. Le chariot comprend une ou plusieurs cellules. Le collecteur d'élimination de fluide comprend un corps, et une ou plusieurs buses fixées au corps. Le dispositif de commande détermine si un fluide dans le chariot doit être éliminé, actionne le collecteur d'élimination de fluide pour aligner la/les buse(s) avec la/les cellule(s) du chariot en réponse à la détermination du fait que le fluide dans le chariot doit être éliminé, et commande le collecteur d'élimination de fluide de sorte à ce qu'il élimine le fluide d'une ou de plusieurs cellules du chariot par l'intermédiaire de la/des buse(s).
Patent UY-26161-A1 (UY)
Title: Derivados de 13-metil eritromicina
Inventor: WU YONG-JIN
IPC: C07H17/08
Filed: 2000-05-24
Abstract: Compuestos de fórmula 1 y a sales, promedicamentos y solvatos de éstos farmaceúticamente aceptables, en los que R1 y R2 son OR8, R2 es omesilo, otosilo, etc tambien R1 y R2 tomados juntos son figura A, R3 es OR10, R4 es H, C(O)alquilo(C1-18), C(O)Ar, etc, R5 es H, un alquilo C1-10, un alquinilo C3-10, etc, R17 es alquilo C1-20, etc, Rf es H, un -C(O9-imidazolilo, etc, A es H o halógeno, X es-C(O)-, etc; e Y es CH2, C(O), CHF, CF2, etc. La invención también se refiere a composiciones farmaceúticas que contienen los compuestos de fórmulas 1, a procedimientos de utilización de los compuestos de fórmula 1 en el tratamiento de infecciones y a procedimientos de preparación de los compuestos de fórmula 1. La Eritromicina es un antibiótico macrólido, son útiles en el tratamiento de un espectro de infecciones bacterianas y protozooarioas en mamíferos, incluyendo humanos, peces y aves. Posee actividad contra bacterias gram positivas y negativas, como neumonía, otitis media, siusitis, bronquitis, tonsilitis, mastoiditis
Patent UY-27426-A1 (UY)
Title: Maleato de sildenafil
Inventor: LLANO RAFAEL
IPC: C07D487/04
Filed: 2002-08-29
Abstract: El maleato de sildenafil es un nuevo compuesto para el tratamiento de la disfunción sexual masculina. El campo de la invención es un procedimiento nuevo para la preparación del sildenafil en maleato que posee una gran actividad vasos dilator sistémica.
Patent UY-27738-A1 (UY)
Title: Aminoácidos con afinidad por la protéina a 2 ó .
Inventor: BARTA NANCY SUE
IPC: A61P21/00
Filed: 2003-03-27
Abstract: Esta invención se refiere a ciertos B-amino ácidos que se unen a la subunidad alfa-2-delta (a2ó) de un canal de calcio. Estos compuestos y sus sales farmacéuticamente aceptables son útiles en el tratamiento de una variedad de trastornos psiquiátricos del dolor y otros.
Patent UY-31235-A1 (UY)
Title: Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
Inventor: KREHER CHRISTOPH
IPC: A61K9/72
Filed: 2008-07-17
Abstract: La invencion se refiere a preparaciones estables pulverulentas para la inhalacion, que contienen una sal de tiotropio y xinafoato de salmeterol, a procedimientos para su preparacion, así como su uso para la preparacion de un medicamento para el tratamiento de las vías aéreas, en especial para el tratamiento de EPOC (chronic obstructive pulmonary disease = enfermedad pulmonar obstructiva cronica) y asma.
Patent UY-31302-A1 (UY)
Title: Derivados de azoloarina, procedimientos para su preparacion, medicamentos que comprenden estos compuestos y su uso.
Inventor: JUAN-ANTONIO DR SANCHEZ-ARIAS
IPC: A61K31/4184
Filed: 2008-08-21
Abstract: La invencion se refiere a compuestos derivados de azoloarina de la formula I en donde los radicales R,M,W,X,A,B,D y Y tienen los significados indicados, y sus sales fisiologicamente toleradas. Los compuestos son adecuados, por ejemplo, para el tratamiento del síndrome metabolico, la resistencia a la insulina, la obesidad y la diabetes.
Patent UY-31381-A1 (UY)
Title: Formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-trifluoro-1-(3´-metoxibifenil-4-il)etoxi)pirimidin-4-il)fenil)propanoico y sus métodos de uso
Inventor: ZHAO MATTHEW MANGZHU
IPC: C07D239/00
Filed: 2008-10-07
Abstract: Se describen formas sólidas de ácido (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3´-metoxibifenil-4-il)etoxi)pirimidin-4-il)fenil)propanoico y sus sales.
Patent ES-181361-A1 (ES)
Title: PERFECCIONAMIENTOS EN MEZCLADORES PARA COMPOSICIONES PLáSTICAS CAPACES DE RáPIDO FRAGUADO A MASA SoLIDA
IPC: B01F15/00
Filed: 1947-12-31
Abstract: Perfeccionamientos en mezcladores para composiciones plásticas capaces de rápido fraguado a masa sólida, comprendiendo, un depósito dentro del cual es continuamente descargada la composición plástica por al parte superior y continuamente extraida por el fondo y un agitador de paletas próximo al fondo del depósito giratorio alrededor de un eje vertical, por lo que el depósito está hecho con diámetro más pequeño en el fondo que en la parte alta, para los fines antes indicados.
Patent ES-188391-A1 (ES)
Title: NUEVO SISTEMA DE ACCIONAMIENTO DE LOS VENTILADORES EN LOS ELEMENTOS DE CALEFACCIoN POR AIRE
Filed: 1949-05-16
Abstract: Nuevo sistema de accionamiento de los ventiladores en los elementos de calefacción por aire que se caracteriza por ser accionado el rotor del ventilador directamente o por transmisión por una turbina de vapor movida ésta por el propio vapor que ha de alimentar el elemento de calefacción antes de entrar en éste o sea la turbina montada en serie en el circuito de alimentación del vapor del elemento de calefacción.
Patent ES-190962-A1 (ES)
Title: PERFECCIONAMIENTOS INTRODUCIDOS EN LA CONSTRUCCIoN DE HÉLICES
Filed: 1949-12-24
Abstract: Perfeccionamientos introducidos en la construcción de hélices caracterizados porque en cuyas palas sobre si cara dorsal hay practicadas cámaras de aspiración (1) coanunciadas con el exterior a través de unas superficies agujereadas o porosas (2).
Patent ES-193441-A1 (ES)
Title: UNA PRENSA HIDRáULICA PARA EMPACAR
Filed: 1950-06-15
Abstract: Prensa hidráulica para empacar caracterizada porque el empacado que realiza la máquina es enteramente hidráulico prescindiendo de movimientos mecánicos como cremalleras cadenas husillos con lo que aporta grandes ventajas muy principalmente en la simplificación del trabajo y de esfuerzos musculares al igual que de hombres.
Patent ES-291422-A1 (ES)
Title: Direct coupled circuit utilizing fieldeffect transistors
IPC: H01L29/00
Filed: 1963-09-06
Abstract: A circuit arrangement including an insulated gate field effect transistor (MOS transistor) comprises an input circuit connected between the gate and source electrodes such that a zero D.C. potential is maintained therebetween under " no signal " conditions and an output circuit connected between the drain electrode and a point of reference potential for the circuit to which the source is directly connected. The input impedance of the transistor is of the order of 1014 # and in general it is so constructed (see Division H1) that the zero gate bias curve 47 of the drain current-drain voltage characteristic lies in the middle of the linear operating region of the transistor. A tuned I.F. amplifier using such a device is depicted in Fig. 4 (not shown). In the superhet second detector circuit of Fig. 5 the MOS transistor 108 is selected to have a zero bias characteristic which corresponds to curve 49 (Fig. 2), so that for low level input signals it operates substantially linearly and for high level negativegoing signals the bias point is moved towards the centre of the linear operating range so as to ensure that these signals are also amplified linearly. AGC or amplified AGC may be derived from resistors 104 or 110 respectively. In a similar embodiment (Fig. 6, not shown), the gate electrode 107 is connected to the " top " of the gain control 104 and its slider 106 is connected through a capacitor to earth. An AF amplifier is described with reference to Fig. 7 (not shown), wherein a piezo-electric pick-up is connected across a potentiometer, the wiper of which is connected to the gate electrode of the M.O.S. transistor. A direct coupled linear amplifier in which the first M.O.S. transistor is chosen to have a zero bias characteristic corresponding to curve 47 and later transistors are chosen to have zero bias characteristics corresponding to one of the curves 43 to 46 in dependence upon the drain current flowing in the immediately preceding transistor under " no signal " conditions is depicted in Fig. 8 (not shown).
Patent ES-316643-A1 (ES)
Title: Improvements in combine harvesters
IPC: A01D41/14
Filed: 1965-08-19
Abstract: A means for indicating the height of a feed table of a combine harvester which is pivotable about a horizontal axis comprises a rod 25 pivotably attached to an elevator housing 3 and having thereon an adjustable boss 36 which, during lowering and raising of the feed table, contacts and depresses actuating members 21 of micro-switches 17, 18 which are each in series with the battery of the combine and a pilot lamp located near the operator. The micro-switches may be adjustable in a direction longitudinally of the rod. In operation the boss is positioned on the rod such that actuation of the switch 17 alone and of switches 17, 18 together will define respectively an upper predetermined cutting level and a lower predetermined cutting level of the table above the ground.
Patent ES-336869-A1 (ES)
Title: 3,4-cis-4-aryl-isoflavanes
IPC: C07D311/58
Filed: 1967-02-15
Abstract: Novel compounds of the formula <FORM:1103094/C2/1> where R1 is H or an alkyl containing 1-3 C atoms, R2 and R3, which may be the same or different, are H, OH, alkoxy or acyloxy containing 1-6 C atoms, -O-(CH2)n-NR4R5, -OSO3H, -OPO3H2, or OCH2COZ, R4 an R5 are each an alkyl containing 1-4 C atoms or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered ring, X and Y are H or F, Z is OH, an alkoxy containing 1-6 C atoms, -NH2 or an alkylated amino group which contains 1-6 C atoms or which may form part of a heterocyclic ring and n is 2 or 3, are prepared by hydrogenating the corresponding 3-isoflavene derivatives. Therapeutic compositions, suitable for parenteral, enteral, or topical application, contain the above novel compounds or their physiologically acceptable acid addition metal, ammonium, or quaternary ammonium salts as the active ingredient. The compositions have a good antifertility action and some of them also have oestrogenic or anti-oestrogenic, gonadotropin-inhibiting, ovulation-stimulating or hypocholesterolaemic properties.
Patent ES-342899-A1 (ES)
Title: Electrolytic method for producing a colored anodized layer on aluminum and alloys of aluminum
IPC: C25D11/14
Filed: 1967-07-11
Abstract: The invention is addressed to the coloring of aluminum and alloys of aluminum by anodization wherein the aluminum article is immersed as the anode in an electrolytic bath formulated of an aqueous solution of a naphthalene sulphonic acid or alkali metal salt thereof and sulphuric acid, with or without an aliphatic acid of carbon atoms.
Patent ES-344047-A1 (ES)
Title: Benzenesulphonyl-ureas and process for their manufacture
IPC: C07D309/14
Filed: 1967-08-11
Abstract: Novel compounds of the general formula and their physiologically tolerable salts with bases, for example sodium salts, wherein X represents a chlorine or bromine atom or a methyl group linked to the 4- or 5-position with respect to the carboxylic amide group, preferably a chlorine atom, and Y represents a hydrogen atom or a methyl group are prepared by one of the following methods: (a) Reacting a benzenesulphonyl-isocyanate, -carbamic acid ester, -thiolcarbamic acid ester, -urea, -semi-carbazide or -semicarbazone carrying the substituent of formula in the p-position with an amine carrying the substituent of Formula III or a salt thereof (b) reacting a sulphonamide of the formula or a salt thereof with an isocyanate, carbamic acid ester, thiolcarbamic acid ester, carbamic acid halide or urea carrying the substituent of Formula III (c) hydrolysing a correspondingly substituted benzenesulphonyl-isourea ether, -isourea ester, -isothiourea ether, -parabanic acid or -haloformic acid amidine (d) adding water on to a correspondingly substituted carbodiimide (e) replacing the sulphur atom in a correspondingly substituted benzene-sulphonyl-thiourea by an oxygen atom (f) hydrogenating a corresponding benzenesulphonyl-urea containing, in the molecule, an unsaturated linkage and (g) introducing by acylation the radical of formula into a benzenesulphonyl-urea of the formula and, if desired, converting the resulting compound into a physiologically tolerable salt thereof by reaction with a base. N - [4 - (beta - <2 - methoxy 5 - chloro - benzamido > - ethyl) - benzenesulphonyl] - N1 - acetylurea is prepared by acylation with acetic acid anhydride of the amine. N,N1 - bis - 4 - [beta - < - 2 - methoxy - 5- chloro - benzamido > - ethyl) - benzenesulphonyl]- urea is prepared by treatment of the corresponding carbamic acid with ammonia in the presence of the corresponding sulphonamide. N - [4 - (beta - < 2 - methoxy - 5 - chloro - benzamido > - ethyl) - benzenesulphonyl] - 3 - cyclohexyl-parabanic acid is prepared by reaction of N - cyclohexyl - parabanic acid and 4 - (beta- [2 - methoxy - 5 - chloro - benzamido] - ethyl)- benzenesulphochloride. N - [4 - beta - < 2 - methoxy - 5 - chloro - benzamido > ethyl) - benzenesulphonyl] - N1 - cyclohexyl-isothiourea methyl ether is prepared by reaction of cyclohexylamine and N1[4-(beta-<2- methoxy - 5 - chloro - benzamido > ethyl) - benzenesulphonyl] - imino - dithiocarbonic acid dimethyl ester which is itself prepared by reaction of dimethyl sulphate on the potassium salt of the corresponding dithiocarbonic acid. Pharmaceutical compositions in conventional form for oral or parenteral administration useful in treating diabetes comprise an above novel compound and a suitable pharmaceutical carrier.
Patent ES-352281-A1 (ES)
Title: Reversible stepping mechanisms
IPC: F16H31/00
Filed: 1968-03-23
Abstract: Ratchet mechanism for imparting step-bystep rotary motion in either direction to a shaft 3 comprises a ratchet-wheel 4, secured to the shaft 3 and having teeth shaped substantially as isosceles triangles, and pivotally mounted pawls 11 located one each side of the ratchetwheel 4 and each carrying a spring-biased tongue 14 adapted to engage a tooth of the ratchetwheel near the apex of the tooth and to slide down the trailing flank of the tooth on operation of an appropriate solenoid 6, thereby to rotate the ratchet-wheel through one step. Each pawl 11 has an end 13 of inverted U-shape in which the tongue 14 is located, the tongue being pivotally mounted in a slot 16 and having a portion 15 to which a spring 17 is attached. Stop pins 19 limit rocking movements of the pawls 11. A spring detent 18 abuts the ratchetwheel 4.
Patent ES-354198-A1 (ES)
Title: Bearing for a rotating shaft
IPC: F16C39/06
Filed: 1968-05-22
Abstract: A rotary shaft 1 is supported in a magnetic bearing comprising a magnetic circuit 12, having two fixed polepieces 13 and 14 and an electromagnetic coil 15, and a member 6 supported by one of the polepieces by flexible members 22 and 23 and having a bearing surface 21 which cooperates with a ring 20 attached to the polepiece 13. A wheel 2 of magnetic material is secured to the shaft and is located in the air gap defined by a flange 14a of the polepiece 14 and the member 6. The polepiece 14, member 6 and wheel 2 are provided with teeth 25, 26, 27, 28 to assist aligning of the shaft. If the shaft is knocked out of alignment the magnetic interaction between the teeth of the wheel and member 6 tends to move member 6. This movement is restrained by the resilience of the members 22 and 23, and by the friction between the surface 21 and the ring 20. In addition when the shaft is off centre the surface 10 may engage with the lining 9 of member 6 thereby further cushioning the shaft. The surfaces 9 and 10 are preferably made of PTFE.
Patent ES-378476-A1 (ES)
Title: Wire stop and wire guide in terminals and connectors
IPC: H01R4/20
Filed: 1970-04-11
Abstract: An electrical terminal comprises a crimping ferrule 4, located within a metal sleeve 2, and a conical funnel either separate from or integral with the sleeve 2, the narrow end of the funnel being disposed within an end 8 of the ferrule. An integral funnel is continuous with the sleeve 2 from the bent portion 9. A separate funnel 13 engages a serrated edge 10, adjacent portion 9, and may be of metal or synthetic resin, the resin providing a waterproof seal between the bared wire 12 and wire insulating sheath 11 when the terminal end, containing the ferrule and funnel, is crimped on to the wire end and insulating sheath. Annular grooves 7 in the ferrule and the serrated edge 10 aid retention of the wire within the terminal end. Two such terminal ends may be formed together to connect two wires together or one may be provided with a flat ring tongue 5. Insulation 3 covers the terminal end.
Patent ES-378543-A1 (ES)
Title: Improvements in door sockets for safes
IPC: E05G1/026
Filed: 1970-04-14
Abstract: A frame for a removable safe door comprises a rigid ring 1 having inwardly projecting door-engaging formations 5, a peripheral portion 2 provided with blind tapped holes 4 for location purposes and a lug 6 to receive a looking bolt 7.
Patent ES-380116-A1 (ES)
Title: Organic peroxides derived from unsaturated compounds
IPC: C08F4/36
Filed: 1970-05-27
Abstract: Elastomers or plastomers, such as polyethylene or ethylene/propylene copolymers are crosslinked or vulcanized by heating at 150 to 170 C. for from 5 to 15 minutes in the presence of, as cross-linking or vulcanizing agent, a compound of the Formula I where R 1 is a cycloalkyl, aryl or heterocyclic radical, each of which may be alkyl or halogen substituted, R 2 is a hydrogen atom or an alkyl aryl or cycloalkyl radical, each of which may be optionally alkyl or halogen substituted or R 1 and R 2 together with the carbon atom to which they are attached form a cycloaliphatic ring which may be alkyl, aryl, aralkyl, alkylidene or arylalkylidene substituted, R 3 and R 4 are each a hydrogen atom or an alkyl, aryl or cycloalkyl radical any of which may be alkyl or halogen substituted, or R 3 and R 4 together may form a cycloaliphatic ring which may be alkyl, aryl, aralkyl, alkylidene or arylalkylidene substituted, R 5 and R 6 are each an alkyl, aryl, aralkyl or cycloalkyl radical any of which may be alkyl or halogen substituted. A preferred composition comprises in parts by weight ethylene/propylene copolymer 100, carbon black 10-80, zinc oxide or magnesium oxide 1-10, sulphur 0À15-0À5, compound I 0À005-0À02 mols.
Patent ES-395483-A1 (ES)
Title: Apparatus for processing of finely divided particulate materials
IPC: C09C1/30
Filed: 1971-09-28
Abstract: A mass of finely divided material is confined in a chamber. Two rollers are arranged for rotation in the chamber in axial parallelism with one another and define with each other a narrow longitudinally extending gap. At least one of the rollers has a circumferential wall composed of gas-permeable porous material. This one roller is hollow and arranged to communicate with a source of underpressure so that, as the roller rotates, the particulate material is attracted onto its outer surface forming a layer thereon which is subjected to substantial compaction when it passes through the gap between the two rollers. The rollers rotate in opposite direction. The compacted material is removed from the outer surface of the roller or rollers and subdivided into portions of desired size. A roller for use in the apparatus is disclosed.
Patent ES-397745-A1 (ES)
Title: Spreader
IPC: A01C15/00
Filed: 1971-12-07
Abstract: A spreader, e.g. fertilizer, comprises an oscillating spreading mechanism, owing to which the spreader as well as the towing vehicle are subject to considerable oscillating movements, causing much wear to said spreader and vehicle and worrying the human driver. The spreader according to the invention is more quiet and/or can spread fertilizer over a considerably larger width, in that compensation mass for damping movements is supported by the frame of the spreader.
Patent ES-404646-A1 (ES)
Title: Contrast agent for angiography and urography
IPC: A61K49/04
Filed: 1972-07-07
Abstract: 3-(N- beta , gamma -dihydroxypropyl-acetyl-amino)-5-acetylaminomethyl-2,4,6-triiodobenzoic acid and its non-toxic, water-soluble salts with alkali metals and amines are better tolerated by the central nervous system for intracerebral and intracisternal application than X-ray contrast agents available heretofore for cerebral angiography. They are preferentially excreted from the blood by the kidney in a manner to make them useful for urography.