baber/WOPTO huggingface dataset:
Patent CO-6160339-A2 (CO)
Title: Antagonistas de ccr2 para el tratamiento de fibrosis
Inventor: DAS ANUK
IPC: A61K39/395
Filed: 2009-04-08
Abstract: 1.- Un método para inhibir por lo menos una proteína quimioatrayente de monocitos 1 (MCP-1) humana en un paciente que tiene por lo menos una forma de fibrosis usando por lo menos un antagonista de MCP-1, que comprende administrar una cantidad efectiva inhibidora de MCP-1 de por lo menos un antagonista de MCP-1. 2.- El método de conformidad con la reivindicación 1, en donde dicho antagonista de MCP-1 se selecciona de una molécula pequeña y una proteína. 3.- El método de conformidad con la reivindicación 2, en donde dicha molécula pequeña se selecciona de derivados de indol, derivados de amina cíclica, derivados de ureido, heterocíclicos, anilidas o pirroles funcionales con la capacidad para bloquear la unión de CCL2 a CCR2B, o inhibición de CCR1 o CCL2 mismo. 4.- El método de conformidad con la reivindicación 2, en donde dicha proteína se selecciona de un receptor soluble, un anticuerpo, un péptido, un fragmento del mismo o una proteína de fusión del mismo. 5.- El método de conformidad con la reivindicación 4, en donde dicha proteína además comprende un compuesto o proteína que incrementa la vida media en el suero de dicha proteína. 6.- El método de conformidad con la reivindicación 4, en donde dicho anticuerpo comprende por lo menos una región variable que comprende por lo menos una región variable de cadena pesada y por lo menos una cadena ligera, dicho anticuerpo de MCP-1 comprende regiones variables de cadena pesada y de cadena ligera que comprenden SEQ ID NOS: 27 y 28. 7.- El método de conformidad con la reivindicación 4, en donde dicho anticuerpo comprende por lo menos una región variable de cadena pesada y por lo menos una región variable de cadena ligera, dicho anticuerpo comprende todas las secuencias de aminoácidos de la región determinante de complementariedad (CDR) de cadena pesada y cadena ligera de SEQ ID NOS: 6, 7, 9, 13, 14 y 16.
Patent CO-6261382-A2 (CO)
Title: Compuestos de imidazotiazol como moduladores de sirtuina
Inventor: BEMIS JEAN
IPC: A61K31/429
Filed: 2010-01-08
Abstract: 1.- Un compuesto representado por la Fórmula Estructural (III):o una sal de ésta, donde: R es -H o -CH3; R1 es un grupo heterociclilmetil sustituido o no sustituido conteniendo nitrógeno; R2 es-H o -CH3 y R3 es un grupo piridil no sustituido.2.- El compuesto de la Reivindicación 1, donde R1 es un grupo heterociclilmetil conteniendo un átomo de nitrógeno y opcionalmente un segundo heteroátomo seleccionado de nitrógeno y oxígeno.3.- El compuesto de la Reivindicación 2, donde R1 es un (substituido o no substituido no-aromático heterocíclico) grupo metil.4.- El compuesto de la Reivindicación 3, donde R1 es un grupo morfolinometil.5.- El compuesto de la Reivindicación 1, donde R1 es un grupo 1,2,4-triazolilmetil.
Patent CO-6270160-A2 (CO)
Inventor: MAISCH CHRISTOF
IPC: E04B2/78
Filed: 2010-02-12
Abstract: The invention relates to a profile element, in particular a construction profile, for example a dry construction profile, a profile for facades or a rendering profile, comprising, in particular a metallic profile body (17, 18) and at least one sealing element (9, 10, 11). Said sealing element is fixed. at least to a longitudinal side of the profile body and is made of a plastic. Openings (13) are embodied in. the longitudinal side of the profile body and the sealing element comprises projections (12) that are embodied as a single piece with the sealing elements for fixing to the profile body (17, 18, 20) on the side of said sealing elements that face the profile body (17, 18, 20), said projections protruding through the openings. The invention also relates to a method for producing said type of profile element.
Patent CO-6361873-A2 (CO)
Title: Despachador de hoja absorbente que tiene funcionamiento mejorado de sensor de manos
Inventor: FORMON JOHN S
Filed: 2011-06-30
Abstract: Un despachador de manos libres para despachar tramos de productos de hoja absorbente, incluye un cuerpo despachador que contiene un mecanismo despachador; un sensor de manos para detectar la presencia de la mano de un usuario en la cercanía del despachador; un elemento conductivo metálico alargado que tiene un extremo próximo en comunicación eléctrica con cuando menos una superficie de metal del despachador colocada en una primera ubicación con relación al sensor de mano, y un extremo distante en comunicación eléctrica con cuando menos un receptor de carga colocado en una segunda ubicación relativa al sensor de manos, la segunda ubicación estando a una mayor distancia desde el sensor de manos que la primera ubicación.
Patent CO-6612243-A2 (CO)
Title: Derivados de [1.8]naftiridina
Inventor: DORSCH DIETER
IPC: A61K31/4375
Filed: 2012-12-27
Abstract: La presente invención se refiere a nuevos derivados de [1 ,8]naftiridina de la fórmula (1) y al uso de tales compuestos en donde la inhibición, regulación y/o modulación de la transducción de señales por proteínas que consumen ATP como 5 quinasas desempeña un papel importante, en particular a inhibidores de las quinasas TGF-beta receptoras y al uso de tales compuestos para el tratamiento de enfermedades inducidas por quinasas, en particular para el tratamiento de tumores.
Patent CO-6680648-A2 (CO)
Title: Dispositivo y ensamble de seguridad para aguja
Inventor: WOHER KEVIN
IPC: A61M5/32
Filed: 2013-02-20
Abstract: Se revelan aquí catéteres intravenosos de seguridad (CIV5) que tienen un cono de catéter (102) con un tubo de catéter (112), una aguja con un cono de aguja y una funda para la aguja (204). La funda para la aguja está configurada para ubicarse al menos parcialmente dentro de un espacio interior del cono del catéter y se retiene al mismo mediante ajuste mecánico entre los dos. Después de la remoción de la aguja del cono del catéter, la funda para la aguja se configura para desajustarse del cono del catéter, y unirse sobre una punta de la aguja para proteger la punta de la aguja de pinchazos accidentales. La funda de la aguja tiene una sección final angular configurada con un largo y un ancho para retener la punta de la aguja dentro de un espacio para retener la punta detrás de la sección final angular.
Patent EP-1041592-A2 (EP)
Inventor: HERDEGEN REINHARD DIPL-ING
IPC: H01H13/04
Filed: 2000-03-20
Abstract: The device has a hollow cylindrical housing (2) containing a movable hollow cylindrical piston (3). It also contains a retur spring (4) supported at one end against the housing and at the other end against the spring. A light element, particularly a bul arranged inside the piston. A switch element (13) is fastened to the bulb end of the housing. A plastic part (14) is integrated the end of the housing. The rest of the housing is made of metal.
Patent EP-1058233-A2 (EP)
Inventor: KWON OH-KYONG
IPC: G02F1/133
Filed: 2000-06-02
Abstract: There is provided a liquid crystal display and a circuit for driving the same, having a higher resolution and being able to be manufactured at low cost. The liquid crystal display having first and second plates and a liquid crystal being sealed therebetween includes: a plurality of scanning lines arranged on the first plate in one direction; a plurality of data lines arranged on the first plate, intersecting the scanning lines; first and second pixel regions, located at both sides of each data line, respectively; a first switch for selectively transmitting a video signal loaded on a corresponding data line to the first pixel region; and a second switch for selectively transmitting the video signal loaded on the data line to the second pixel region.
Patent EP-1070863-A2 (EP)
Inventor: CYZYCKI STANISLAUS
IPC: B21B27/00
Filed: 2000-06-30
Abstract: The roller comprises a metal core (1) and a soft elastomeric coating (2). A rigid, conical elastomeric layer (4) and a conical, slightly expandable support layer (5) are positioned under this. There is an air gap between the two which allows them to move sideways with respect to each other.
Patent EP-1077404-A2 (EP)
Inventor: DYE ROBERT
IPC: H04L29/06
Filed: 2000-08-18
Abstract: A system and method for programmatically/dynamically creating or editing a graphical program. A first
program may be created, wherein the first program specifies creation of a new graphical program. When the first
program is executed, the new graphical program is programmatically created, in response to executing the first
program. Thus, during execution of the first program, the first program is operable to cause creation of the new
graphical program. The first program may specify the inclusion of various objects in the new graphical program.
For example, the new graphical program may have a diagram portion including a plurality of interconnected nodes
which visually indicate functionality of the new graphical program. The new graphical program may also have a
user interface portion including various user interface objects. In a related embodiment, a first program may specify
the modification of an existing graphical program. When executed, the first program causes the existing graphical
program to be modified, e.g., by modifying various objects of the graphical program. The first program may call an
application programming interface (API) usable for programmatically creating a new graphical program or
modifying an existing graphical program. The first program may be operable to interface with a server program,
e.g., a graphical programming development environment application, in order to programmatically request the
server program to create the new graphical program or modify the existing graphical program.
Patent EP-1079158-A2 (EP)
Inventor: MOCK RANDOLF DR
IPC: H01L41/053
Filed: 2000-08-22
Abstract: The dispensing device includes a dispensing opening controlled by displacing a valve pin. An electromechanical actuator (8) of variable length in the axial direction is arranged within the working chamber of the housing (1) of the dispensing device, and is connected to the valve pin on one side and an axially displaceable hydraulic piston on the other side. A hydraulic chamber (13) is hydraulically connected via a choke, through a seat (11) to the working chamber so that when the length of the actuator changes rapidly, the hydraulic piston is fixed relative to the housing. The hydraulic chamber can be pressurised via the working chamber through the seat. The actuator may be a multi-layer piezo actuator.
Patent EP-1112937-A2 (EP)
Inventor: FOCKE HEINZ
IPC: B65B51/14
Filed: 2000-11-24
Abstract: The thermic closure device has a heated closure plate (22) cooperating with a counter-plate (24) having an elastically deformable bearing surface supporting the foil packaging (10), with a movement device converting the continuous rotation of a drive shaft into a reciprocating movement of the heated closure plate. An Independent claim for a movement device for operation of a thermic closure organ is also included.
Patent EP-1028521-A2 (EP)
Inventor: MANLOVE GREGORY
IPC: H02P6/08
Filed: 2000-02-07
Abstract: Circuitry (100, 100') for determining actuator position includes
four MOS transistors (T1-T4) connected to each side of a bi-directional motor
(10). The current flowing through the motor (10) at any given time is
proportional to voltages developed across the internal impedances of the
transistors (T1-T4). The resulting motor voltages are amplified and high-pass
filtered to remove any DC offsets due to the signal amplification. The
conditioned motor voltages are then compared to one or more threshold
voltages and passed through a one shot circuit (120) to provide detectable pulses
for each motor commutation event. Circuitry (106,107) is provided for
counting pulses provided by the one shot circuit (120) and, based on a desired
motor position, for providing a number of digital control signals to a digital
control circuit (104). Digital control circuit (104) is responsive to the number of
digital control signals to control the gate voltages of the four transistors (T1-T4)
to thereby control the position of the motor (10).
Patent EP-1022458-A2 (EP)
Inventor: DINGLE PHILIP JOHN GREGORY
IPC: F02M43/02
Filed: 2000-01-05
Abstract: A fuel system comprising a unit pump/injector (10) and a cam actuated plunger
pump (21) arranged to supply an auxiliary fluid to the injector, wherein the
plunger pump (21) is located adjacent the unit pump/injector (10).
Patent EP-1046984-A2 (EP)
Title: Automatic stub/adapter generator
Inventor: CLICK JR CLIFFORD N
IPC: G06F9/45
Filed: 2000-04-25
Abstract: Systems and methods for automatically providing an adapter or a stub in a runtime
environment are provided. An adapter generator is provided with input parameters that
are in turn processed and input to a compiler. The compiler, in turn, is coupled to an
adapter library used to store the generated adapters. The adapter library, in turn, provides
adapters, on demand. to a runtime system when executing a bytecode, or a series of
bytecodes.
Patent EP-1068885-A2 (EP)
Inventor: ADAMS JOHN
IPC: A63F3/08
Filed: 2000-07-14
Abstract: A video lottery system comprises a central
controller (10) that provides fixed pools of chances
in electronic form. These are downloaded on request to
a local master (30) at a given location (40) such as a
club. The local master is connected to a ticket
dispenser (50). A person wishing to play a game of
chance approaches a vendor in the location (40), who
enters information into the ticket dispenser (50) in
exchange for cash. The ticket dispenser prints out a
ticket and this is handed to the player. Each ticket
printed represents a fixed chance (win or lose)
obtained from the fixed pool. 
     The player inserts the purchased ticket into a
separate lottery machine (60) which reads the ticket
and indicates to the player, via a screen (70),
whether the ticket represents a winning or losing
chance.
Patent EP-1072804-A2 (EP)
Inventor: SHI YONGWEI
IPC: H02K7/08
Filed: 2000-07-18
Abstract: To provide a magnetic bearing device capable of obtaining
a sufficient force to control a rotating member through the
entire frequency range, capable of preventing touchdown,
smaller in size, and having lower power consumption. Grooves
are formed in the inner surface of a stator defining a hole
for a shaft. Also, grooves are formed in an upper surface of a
projecting portion facing a disk fixed to one end of the shaft.
As the shaft rotates, dynamic pressure of air is produced
between the shaft and the stator hole surface and between the
bottom surface of the disk and the upper surface of the
projecting portion. If the stiffness for position adjustment
with electromagnets becomes lower in a frequency range (e.g.,
about a resonance point) in which the gain of transfer
function G(s) decreases, this dynamic air pressure acts to
compensate for deficiencies of the magnetic attractions of the
electromagnets. Sufficiently large control forces are thereby
obtained.
Patent EP-1085352-A2 (EP)
Inventor: HIRAOKA TOSHIRO
IPC: G02B6/122
Filed: 2000-09-13
Abstract: Disclosed is a three dimensional structure
comprising a porous body (1) and a plurality of regions
(2) having a substance loaded in the porous body.
An average period of a part of the plural regions
loaded with the substance is 0.1 to 2 µm to form
a photonic band.
Patent EP-1110454-A2 (EP)
Inventor: MICHELOTTI ENRIQUE LUIS
IPC: C02F1/50
Filed: 2000-12-04
Abstract: The present invention relates to a method for inhibiting the growth of
microorganisms and marine organisms at a locus. In particular, the present
invention relates to the use of certain 5-carboxanilido-haloalkylthiazoles as
antimicrobial and marine antifouling agents.
Patent EP-1046831-A2 (EP)
Inventor: NADAL ALOY JORDI
IPC: F16D65/092
Filed: 2000-04-12
Abstract: Improved disc brake, of the type comprising a disc (1)
in the shape of a flat circular crown having at a point of its
periphery, two facing braking pads (4) fitted to press the disc (1)
inserted between said pads (4). The brake is characterized in that
at the disc inside perimeter there is a plurality of
radially-arranged entrants (3), regularly distributed and
preferably back-bent with respect to the rotation sense of the
disc (1). Each of the brake pads (4) facing the disc (1) has on the
face rubbing said disc an arcuated recess (2) in the sense
associated with the previously cited entrant (3), from a mutual
interference area to the pad external profile, an air
communication is formed at the mutual interference area of
the entrant (3) and the recess (2) which is cooling the brake unit.
Patent EP-1094166-A2 (EP)
Inventor: GONZALEZ BARDAVIO JESUS
IPC: E04C1/39
Filed: 2000-10-18
Abstract: IMPROVED BRICK FOR CONSTRUCTION, of the type used in construction work
for the building of different kinds of walls and partition walls, presenting a series of
hollows, making it lighter, and a tongue and grooved outline allowing it to slot into
other similar bricks. The brick is essentially distinguished by its preferably
parallelopipedic form and in the tongue and grooved outlines presenting one or more
lengthways channels in the form of a round arch, which correspond with similar
grooves in the adjacent element, forming a series of vertical and horizontal channels
between both bricks, suitable for the installation of electrical wiring, water, gas, central
heating or other pipes, without the need to cut into or make recesses or other holes in
the wall. The said channels being sufficiently wide to allow for the said installations,
which are bordered by areas not affected by the channel, allowing adjacent bricks to be
firmly joined together by means of a cement or plaster grout, glue or any other joining
material. The channel existing around the brick may be single or multiple and parallel,
suitable for the constitution of parallel and independent installations.
Patent EP-1120921-A2 (EP)
Inventor: HAENNINEN JOUNI
IPC: H04B1/52
Filed: 2000-12-28
Abstract: The invention relates to a transceiver and a method for
receiving a RF signal in a transceiver. The invention relates
in particular to mobile stations of mobile telecommunication
systems that employ both time division duplex (TDD)
and frequency division duplex (FDD) to provide isolation
between transmission and reception. An idea of the invention
is to control (29) the bias of the LNA-type preamplifier
(2) in the reception in such a manner that when receiving
during transmission, a greater bias is used than when
transmission is not taking place. This way the amplifier will
have a great bias when a signal from the transmitter part
(17-26) is coupled to the receiver part, and since increasing
the bias will improve the linearity of the amplifier (2), less
unwanted components will appear in the amplifier. The
mean power consumption in the receiver will, however,
remain reasonably small because a small bias will be used
during the times when no transmission is taking place.
Patent EP-1179151-A2 (EP)
Inventor: FEDERHEN BERND
IPC: F16K1/00
Filed: 2000-02-15
Abstract: Bei einer aufblasbaren Dichtung (20) ist in einen Aussenteil (24) aus elastischem Werkstoff ein Innenkörper (22) aus formstabilem Werkstoff eingebettet, wobei zumindest ein an letzteren grenzender Werkstoffstreifen (25) des Aussenteils (24) mit äusserer Dichtfläche in der Art einer beweglichen Membrane ausgebildet und gegenüber dem Innenkörper (22) getrennt ist; zwischen dessen Unterfläche (23) und jenem Werkstoffstreifen (25) befindet sich ein mit einem Druckmedium beaufschlagbarer Spaltraum (40).
Patent EP-1171583-A2 (EP)
Inventor: SANTI DANIEL V
IPC: A61P31/04
Filed: 2000-04-12
Abstract: A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
Patent EP-1192572-A2 (EP)
Inventor: LEVCHIN MAX
IPC: G06Q40/00
Filed: 2000-04-28
Abstract: A system and method are provided for facilitating a value exchange transaction involving multiple parties. The system may comprise a synchronization server for exchanging transaction details with client devices, a communication server for registering new users, a financial server for interacting with external financial institutions, and a security server for ensuring the security of value exchange transactions. In one method, a first party initiates a transaction on a client (e.g., a mobile computing device) by selecting or inputting an identifier (which may be pre-existing, such as a telephone number) of another party and a value to be exchanged. The transaction may be conducted while the parties' client devices are electronically connected or may be conducted by one user on one device. Transactions are communicated to a system server during a synchronization between a party's client device and a system server. When the transaction is submitted to the system, if the second party is not a registered user of the system he or she is invited to register and complete the transaction.
Patent EP-1231889-A2 (EP)
Inventor: ROSE DAVID
IPC: A61K8/41
Filed: 2000-10-04
Abstract: A coloring or tinting composition containing as a substantive dye at least one hydroxyanthraquinone derivative of formula (I) is provided. Preferred hydroxyanthraquinone derivatives include 1,4-dihydroxy-6-chloro-7-(3'-methylphenoxy)-anthraquinone,1,4-dihydroxy-6-chloro-7-(2'-methyl-3'-hydroxyphenoxy)-anthraquinone, 1,4-dihydroxy-6-chloro-7-(4'-methylphenoxy)-anthraquinone, 1,4-dihydroxy-6-chloro-7-(3',5',-dimethoxyphenoxy)-anthraquinone,or 1,4-dihydroxy-6-chloro-7-(2'.3'-dimethoxyphenoxy)-antraquinone.
Patent EP-1232562-A2 (EP)
Inventor: NELSON ROBERT J
IPC: F01D15/10
Filed: 2000-11-22
Abstract: Dans un système (20) de production d'énergie électrique comprenant une turbine (22) et un turbogénérateur (25) relié à la turbine (22) le long d'un arbre commun (21), une excitatrice à induction (30) à courant alternatif (CA) est prévue laquelle est reliée au turbogénérateur (25) afin de démarrer le turbogénérateur (25). L'excitatrice à induction (30) à courant alternatif comprend de préférence une entrée CA (31), un rotor (36) d'excitatrice et un fournisseur de sortie (35) de courant alternatif fixe réagissant à l'entrée (31) CA et positionné en communication électrique avec le rotor (36) de l'excitatrice pour fournir une sortie (34) de courant alternatif au rotor (36) de l'excitatrice, de manière qu'une tension soit produite indépendamment du régime du rotor (36) de l'excitatrice. Le fournisseur (35) de courant alternatif fixe comprend de préférence un redresseur (32) réagissant à l'entrée CA (31) pour redresser le courant alternatif en courant continu (CC) et un convertisseur CC en CA (33) réagissant au redresseur (32) pour convertir l'entrée de courant continu en sortie (34) de courant alternatif. L'invention concerne également un procédé de démarrage d'un turbogénérateur (25).
Patent EP-1537110-A2 (EP)
Title: Composes triazospiro presentant une affinite pour le recepteur de la nociceptine
Inventor: KYLE DONALD
IPC: A61K31/445
Filed: 2000-12-06
Abstract: L'invention se rapporte à des composés représentés par la formule (I) dans laquelle A, R1, R2, R3, R4 et X1 sont définis dans la description associée. Ces composés présentent une affinité pour le récepteur ORL1 et ils s'avèrent utiles pour le traitement des douleurs chroniques et aiguës.