Patent SG-11201900077Q-A (SG)
Title: 1,3-dihydroxy-phenyl derivatives useful as immunomodulators
Inventor: YEUNG KAP-SUN
IPC: C07D417/12
Filed: 2017-07-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MD HIM 0 11101 HOE 3E1 0 01110110111111100111110111110 ill 011 International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/009505 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: CO7D 401/14 (2006.01) CO7D 413/12 (2006.01) CO7D 413/14 (2006.01) CO7D 417/12 (2006.01) CO7D 401/12 (2006.01) A61K 31/4427 (2006.01) C07D 405/12 (2006.01) A61P 37/02 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (21) International Application Number: PCT/US2017/040663 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 05 July 2017 (05.07.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (25) Filing Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (26) Publication Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (30) Priority Data: 62/359,971 08 July 2016 (08.07.2016) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a (72) Inventors: YEUNG, Kap-Sun; c/o Bristol-Myers Squibb patent (Rule 4.17(ii)) Company, 5 Research Parkway, Wallingford, Connecti- — as to the applicant's entitlement to claim the priority of the cut 06492 (US). GRANT-YOUNG, Katharine A.; 1343 earlier application (Rule 4.17(iii)) Boston Post Road, Unit 208, Madison, Connecticut 06443 — of inventorship (Rule 4.17(iv)) (US). ZHU, Juliang; 22 Windsor Road East, North Haven, Connecticut 06473 (US). SAULNIER, Mark G.; c/o Bris- tol-Myers Squibb Company, 5 Research Parkway, Walling- ford, Connecticut 06492 (US). FRENNESSON, David B.; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). MENG, Zhaox- ing; c/o Bristol-Myers Squibb Company, 5 Research Park- way, Wallingford, Connecticut 06492 (US). SCOLA, Paul Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) Michael; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). Agent: MINGO, Pamela A. et al.; Bristol-Myers Squibb (74) Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (81) Title: 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS (54) R 1 Il O .4 lin ,.. ...)... :zz..„ , R 2 R 4 © ..... 0 ,, , ,,,, X , lin (R 3 ), C:r (T) © © tit (57) : The present disclosure generally relates to compounds of formula (I), wherin R2 is a phenyl or pyridinyl moiety, useful Il as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The 0 ei disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.