baber/WOPTO huggingface dataset:
Patent DK-2925776-T3 (DK)
Inventor: AOYAGI-SCHARBER MIKA
IPC: C12N15/62
Filed: 2013-11-27
Granted: 2018-09-03
Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.
Patent DK-0435028-T3 (DK)
Inventor: LUBITZ WERNER DR
IPC: C12R1/19
Filed: 1990-12-15
Granted: 1996-04-01
Abstract: Procedure for releasing poly-3-hydroxy carboxylic acid granules from cells of Gram-negative bacteria containing these by expression of a cloned natural or chimeric lysis gene, in which before induction of lysis gene expression the ionic strength of doubly charged cations is increased to 0.05 to 0.5 mol, expression of the lysis gene is induced by increasing the temperature, the cells are harvested and the still moist cells are resuspended in water or buffer solutions, whereupon the polymer granules are released by spontaneous lysis.
Patent DK-0489201-T3 (DK)
Inventor: ESTRADA GARCIA MARIO PABLO
IPC: C12N15/81
Filed: 1990-07-17
Granted: 1996-03-11
Abstract: The present invention relates to the field of biotechnology and genetic engineering and in particular a novel nucleotide sequence which codes for a streptokinase, as well as the recombinant DNA obtained therefrom which is used for the transformation of various host organisms. The technical object which is pursued with the proposed solution is to produce the protein in commercially useful quantities, by the recombinant method, with the possibility of alternatively using different hosts to obtain a high-quality streptokinase capable of being used as a thrombolytic agent in the treatment of different disorders. The present invention is based on the isolation of a new gene which codes for streptokinase from Streptococcus equisimilis of type C (strain ATCC-9542) and the cloning and expression thereof in prokaryotic (E. coli) and eukaryotic (Pichia pastoris) hosts, for which it includes the vehicles of expression which contain the genetic sequences of said gene, as well as the microorganisms transformed with these vectors capable of producing streptokinase. The protein obtained thereby can be used in clinical medicine as a therapeutic agent, in the treatment of disorders such as thromboembolic obstructions including coronary thrombosis.
Patent DK-0396338-T3 (DK)
Inventor: PARRIS WARREN M
IPC: C22F1/00
Filed: 1990-04-26
Granted: 1995-04-10
Abstract: A titanium-base alloy characterized by a combination of good oxidation resistance at temperatures of at least 1500  DEG F (815 DEG C) and good cold rollability. The alloy consists essentially of, in weight percent, molybdenum 14 to 20, niobium 1.5 to 5.5, silicon 0.15 to 0.55, aluminium up to 3.5, oxygen up to 0.25 and balance titanium. Preferably, molybdenum is 14 to 16, niobium is 2.5 to 3.5, silicon is 0.15 to 0.25, aluminium is 2.5 to 3.5 and oxygen is 0.12 to 0.16. The alloy may be in the form of a cold reduced sheet or foil product having a thickness of less than 0.1 inch (2.54 mm). This product may be produced by cold rolling to effect a reduction within the range of 10 to 80%.
Patent DK-0407089-T3 (DK)
Inventor: PEREIRA MAVIS CLAIRE
IPC: A61K8/00
Filed: 1990-06-27
Granted: 1993-06-07
Abstract: A water-in-silicone oil transparent emulsion is made from a volatile polydimethylsiloxane (1 to 50% by weight), a silicone surfactant (0.1 to 20% by weight), at least one polyhydric alcohol (1 to 50% by weight) and water. The silicone surfactant comprises a polymer of dimethyl polysiloxane with polyoxyethylene and/or polyoxypropylene side chains having a molecular weight of from 10,000 to 50,000 and having the structure: <CHEM>  a having a value of from 9 to 115,  b having a value of from 0 to 50,  x having a value of from 133 to 673, y having a value of from 25 to 0.25.
Patent DK-0405995-T3 (DK)
Inventor: HUSTAD GERALD O
IPC: B65D55/02
Filed: 1990-06-29
Granted: 1994-03-28
Abstract: A reclosable, hermetically-sealed flexible package (1) which has an inner, hermetic peelable seal (16) and a reclosure seal, typically including interlocking closure strips (17, 18), is provided with one or more of various tamper-evident features (21;31;31a;31b;41;51;61;62;63) which provides an easily visible and noticeable indication of disruption thereof of the type that would gain access to the reclosure seal (17, 18).
Patent DK-0425084-T3 (DK)
Inventor: MIKOSHIBA NOBUO
IPC: H01L21/285
Filed: 1990-09-07
Granted: 1996-01-29
Abstract: A process for forming an Al film of good quality according to the CVD method utilizing the reaction between alkyl aluminum hydride and hydrogen, which is an excellent deposited film formation process also capable of selective deposition of Al.
Patent DK-0418043-T3 (DK)
Inventor: GREGORY STUART PHILIP
IPC: A61K31/19
Filed: 1990-09-12
Granted: 1995-05-15
Abstract: The unpleasant taste of water-soluble ibuprofen salts in aqueous solution is masked by incorporating in the solution a taste-masking amount of an alkali metal bicarbonate, alkali metal monohydrogen phosphate or alkali metal tribasic citrate. Preferably, the taste-masking compound is an alkali metal bicarbonate, especially sodium bicarbonate.
Patent DK-0430645-T3 (DK)
Inventor: MAKOFF ANDREW JOSEPH
IPC: C12N15/81
Filed: 1990-11-27
Granted: 1993-10-11
Abstract: A process for the production of tetanus toxin fragment C.
Patent DK-0462175-T3 (DK)
Inventor: HAUK TORE W
IPC: B65D77/06
Filed: 1990-03-06
Granted: 1993-10-18
Abstract: PCT No. PCT/NO90/00046 Sec. 371 Date Oct. 22, 1991 Sec. 102(e) Date Oct. 22, 1991 PCT Filed Mar. 6, 1990 PCT Pub. No. WO90/10579 PCT Pub. Date Sep. 20, 1990.A device is used for storage and transportation of a material such as a liquid in a standard type barrel having a threaded bunghole. The device includes an impermeable flexible bag, normally made of a plastic material, of a shape and volume substantially similar to that of the barrel and intended to be inserted into the barrel through the bunghole. The flexible bag has a relatively rigid, cylindrical neck portion formed with external threads corresponding to internal threads of the barrel bunghole. After having inserted a body portion of the bag into the barrel the neck portion is tightly threaded into the barrel bunghole, the bag is filled through its neck portion and the latter closed by a lid or plug threaded into the bag neck portion. A tubular case facilitates insertion of the flexible bag through the barrel bunghole, while also serving as a package for the bag before use.
Patent DK-0539500-T3 (DK)
Inventor: SHANTZIS MARK D
IPC: E04F17/12
Filed: 1991-06-13
Granted: 1997-08-25
Abstract: A system uses a single chute in a multi-story building to collect into separate large receptacles different categories of wastes already separated by the tenant for recycling. A turntable carries a large receptacle for each category of waste. Control means on each floor enables a tenant to operate the turntable to position a selected receptacle beneath the turntable to receive a particular category of waste. A microprocessor controller and interlocks on the access doors prevent conflicts between floors.
Patent DK-0557292-T3 (DK)
Inventor: FRISCHMANN ALBERT
IPC: F16B37/12
Filed: 1991-10-07
Granted: 1994-08-22
Abstract: The object fastener to the wall (22) of a lightweight material consists of an insert (7) a inner cavity for a fastener. A tool stem (4) with a drill tip (5) protrudes beyond the insert end (14) of for predrilling a cylindrical hole in the wall. - The toll stem of the setting tool (1) is in the form of a flat rod, with its drill tip (5) pushes through the inner cavity of the insert beyond its end.
Patent DK-0531837-T3 (DK)
Inventor: LORENZ GISELA DR
IPC: A01N37/50
Filed: 1992-08-29
Granted: 1996-04-22
Abstract: Fungicidal mixtures of     a) methyl a-methoximino-2[(2-methylphenoxy)methyl]phenyl acetate <IMAGE>  and   b) an azole active compound selected from the following group: (Z)-2-(1,2,4-triazol-1-yl-ethyl)-2-(4-fluorophenyl)-3-(2-chloro- phenyl)-oxirane of the formula <IMAGE> 1-butyl-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl) ethanol (common name hexaconazole), 1-[(2-chlorophenyl)methyl]-1-(1,1-dimethyl)-2-(1,2,4-triazol-1-yl) ethanol 1-(4-fluorophenyl)-1-(2-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol (common name flutriafol) (RS)-4-(4-chlorphenyl)-2-phenyl-2-(1H-1,2,4-triazol-1-yl-methyl)- butyronitril, 1-[2 RS, 4RS; 2 RS, 4 SR)-4-brom-2-(2,4-dichlorphenyl)-tetrahydrofurfuryl]-1H-1,2,4-triazol, 3-(2,4-dichlorphenyl-2-(1H-1,2,4-triazol-1-yl)-quinazolin-4(3H)-on, (RS)-2,2-dimethyl-3-(2-chlorbenzyl)-4-(1H-1,2,4-triazol-1-yl)- butan-3-ol, bitertanol, triadimefon, triadimenol, cyproconazole, dichlobutrazol difenoconazole, diniconazole, etaconazole, propiconazole, flunsilazole, tebuconazole, imazalil, penconazole, prochloraz, tetraconazole or a salt of such an azole active compound and process for combating fungi using this mixture of compounds.
Patent DK-0577040-T3 (DK)
Inventor: BECK GERHARD DR
IPC: C07D319/06
Filed: 1993-06-28
Granted: 1998-02-02
Abstract: A process for the preparation of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate of the formula I <IMAGE> which is a valuable building block for the preparation of HMG-CoA reductase inhibitors is described.
Patent DK-0557211-T3 (DK)
Inventor: SERS ALPHONSE
IPC: C08G12/40
Filed: 1993-01-22
Granted: 1996-08-05
Abstract: Condensation products and their use as fluidizers for hydraulic binders such as cements, plasters and lime. More particularly, products capable of being obtained by condensation in aqueous medium of at least:   - a compound (a) having available at least two amine functional groups,   - an aldehyde (b), - an acid (c) containing at least one SH group, or a salt of such an acid, - an acid (d) containing at least one amine functional group or a salt of such an acid, - and optionally one or more compound(s) (e) capable of releasing one or more sulphonate ions.
Patent DK-0694166-T3 (DK)
Inventor: JACKMAN ROY
IPC: G01N33/493
Filed: 1994-04-12
Granted: 1999-11-22
Abstract: PCT No. PCT/GB94/00766 Sec. 371 Date Dec. 1, 1995 Sec. 102(e) Date Dec. 1, 1995 PCT Filed Apr. 12, 1994 PCT Pub. No. WO92/24554 PCT Pub. Date Oct. 27, 1994Techniques for the detection of disease of the central nervous system, particularly of bovine spongiform encephalopathy or "mad cow disease", scrapie and related states, are provided based upon the detection of a factor present in the urine of affected animals or humans. That factor is defined in terms of elution data from an ion exchange column and by electrochemical characteristics.
Patent DK-0704825-T3 (DK)
Inventor: SEITZ THOMAS
IPC: G07D5/02
Filed: 1995-03-08
Granted: 1998-08-10
Abstract: The coin testing system has the coins (M) introduced into a channel section that is inclined such that the coins roll past a pair of inductive sensors. The channel is of a rectangular cross section and is tilted such that the coins move against one side wall that is ridged to facilitate motion. The inductive sensors have coils (9, 10) set into one side wall and metallic discs (11, 12) set in the other wall such that the coins pass in between. The sensors provide inputs to an electronic circuit (14) that measures the time response of the resistance of each one and determine maximum values. The circuit uses the values to determine the coin thickness.
Patent DK-0754301-T3 (DK)
Inventor: GRANGER VIVIAN
IPC: G01N33/569
Filed: 1995-04-05
Granted: 1999-06-07
Abstract: PCT No. PCT/EP95/01259 Sec. 371 Date Jan. 27, 1997 Sec. 102(e) Date Jan. 27, 1997 PCT Filed Apr. 5, 1995 PCT Pub. No. WO95/27203 PCT Pub. Date Oct. 12, 1995A stabilized cell suspension is prepared by treating the cell suspension with a solution of a heavy metal compound, which has been aged at pH 6.5-7.5 prior to use to allow a precipitate to form, removing the precipitate from the heavy metal solution, mixing the aged heavy metal solution with the cell suspension to form a first mixture, and mixing the first mixture with a paraformaldehyde solution to form a stabilized cell suspension which is still capable of lysis.
Patent DK-0781122-T3 (DK)
Inventor: DUAN DANIEL C
IPC: C09J155/00
Filed: 1995-09-12
Granted: 2000-10-30
Abstract: A transdermal drug delivery device involving a macromonomer-containing acrylate or methacrylate copolymer, a softener, and a drug. Also a pressure sensitive skin adhesive involving a macromonomer containing acrylate or methacrylate copolymer and a softener.
Patent DK-0741726-T3 (DK)
Inventor: BUZZETTI FRANCO
IPC: C07D471/04
Filed: 1995-10-30
Granted: 2000-04-17
Abstract: PCT No. PCT/EP95/04247 Sec. 371 Date Jul. 9, 1996 Sec. 102(e) Date Jul. 9, 1996 PCT Filed Oct. 30, 1995 PCT Pub. No. WO96/16964 PCT Pub. Date Jun. 6, 1996The present invention relates to compound of formula (I)    <IMAGE>  (I)  wherein A is benzene, naphthalene, 5,6,7,8,-tetrahydronaphthalene, quinoline, isoquinoline, indole or 7-azaindole; R1 is -H, -CN, -SO3R4-, -SO2NHR5,   <IMAGE>    -COOR6, -CONHCH2(CHOH)nCH2OH,   <IMAGE>    -NR7R8, -N(CH2CH2OH)2, -NHCH2(CHOH)nCH2OH, -NHCONH2, -NH-C(NH2)=NH, -NHCO(CHOH)nCH2OH,   <IMAGE>    -NHSO2R9, -OR10, -OCH2(CHOH)nCH2OH, -OOC(CHOH)nCH2OH, -OPO(OH)2, -CH2NH2, -C(NH2)=NH, -CH2NHC(NH2)=NH,   <IMAGE>    -CH2OH, -CH2OOC(CHOH)nCH2OH, -CH2OPO(OH)2 or -PO(OH)2; R2 is C1-C6 alkyl, halogen, or hydroxy; R3 is -H or C1-C6 alkyl; R4 is -H, C1-C6 alkyl or -CH2(CHOH)nCH2OH; R5 is -H, C1-C6 alkyl, -CH2(CHOH)nCH2OH or -(CH2)mNMe2; R6 is -H, C1-C6 alkyl or -CH2(CHOH)nCH2OH; each of R7 and R8 independently is -H or C1-C6 alkyl; R9 is methyl or tolyl; R10 is -H, C1-C6 alkyl, or C2-C6 alkanoyl; Z is >CH2, >O, >NH, or >NCH2CH2OH; n is zero or 1; m is 2 or 3; p is 1, 2 or 3; q is zero, 1 or 2; and the pharmaceutically acceptable salt thereof, for use as tyrosine kinase inhibitors.
Patent DK-0743090-T3 (DK)
Inventor: FLIEGL JOSEF
IPC: B01F7/00
Filed: 1996-04-30
Granted: 2001-09-17
Abstract: A tipping mixer-hopper trailer for use in esp. agricultural applications incorporates a powered side-loading flap, and is linked to a power unit. The novelty is that the mixer vat (1) is wider (3) in the direction of transport movement than in the transverse dimension, and that the hopper incorporates two or more mixer blade assemblies (9, 10) whose axes of rotation (8) are spaced and overlapping.
Patent DK-0760386-T3 (DK)
Inventor: MALOT MICHEL
IPC: E01C7/18
Filed: 1996-08-08
Granted: 2003-02-24
Abstract: A very hard bitumen having a penetrability (at 25 degrees C) of 0 - 20, in the prepn. of a bituminous coating with a modulus rigidity greater than 24x10<3> MPa, is used partic. for the formation or reinforcement of highways, in which the bitumen content of the coating is greater than 6% by wt. Also claimed, is the bituminous coating described.
Patent DK-0758928-T3 (DK)
Inventor: JONES DENNIS J JR
IPC: D06M15/277
Filed: 1996-02-09
Granted: 2001-09-24
Abstract: The invention is directed to a method and composition for treating carpet yarn and carpet to thereby enhance its repellency, and preferably to enhance its stain resistance as well. In one aspect of the invention, the method includes the steps of providing a carpet yarn comprising polymeric fibers. An anionic or nonionic fluorochemical compound is provided in an aqueous medium, the aqueous medium having a pH below about 3.5. The carpet yarn is immersed in the aqueous medium. The carpet yarn and aqueous medium are heated after which excess water is removed from the carpet yarn. The aqueous medium preferably also includes an anionic binding compound that acts to impart stain resistance to the yarn.
Patent DK-0877941-T3 (DK)
Inventor: KENYON NORMA S
IPC: C12N5/077
Filed: 1996-11-05
Granted: 2003-05-05
Abstract: A cell population or subpopulation enrichment procedure for separating undesired populations or subpopulations from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population or subpopulation to be eliminated from the sample. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population to be eliminated then are allowed to preferentially settle in the sample and the supernatant including the enriched population or subpopulation is separated from the particles with the population to be eliminated bound thereto. The enriched population supernatant can then be analyzed, utilized as is, have other populations or subpopulations removed or have additional amounts of remaining cells of the previously eliminated populations removed in additional steps.
Patent DK-0865448-T3 (DK)
Inventor: ARAKAWA TSUTOMU
IPC: C07K16/46
Filed: 1996-12-04
Granted: 2004-02-02
Abstract: The present invention relates to an antibody or fragment thereof which recognizes an epitope on a Her2 polypeptide that is recognized by the monoclonal antibody produced by the hybridoma cell line ATCC No. HB-12078. The invention further relates to a hybridoma cell line capable of producing such an antibody. Also, the invention pertains to an  in vitro  method for inducing apoptosis in Her2 expressing cells comprising administering the inventive antibody. Finally, the present invention discloses uses of such an antibody and pharmaceutical compositions comprising the antibody according to the present invention.
Patent DK-0942992-T3 (DK)
Inventor: WANG YANG
IPC: C12R1/91
Filed: 1997-12-17
Granted: 2007-07-02
Abstract: The present invention describes the identification, purification, recombinant production and characterization of novel O-fucosyltransferase enzymes.
Patent DK-0975360-T3 (DK)
Inventor: STINE LISA C
IPC: C12N5/07
Filed: 1998-03-04
Granted: 2006-11-27
Abstract: The present invention relates to a modified live or inactivated bovine respiratory coronavirus and bovine enteric coronaviruses and their antigens used as a vaccine to protect against both bovine respiratory coronavirus and bovine enteric coronavirus diseases, and processes for making and using the same.
Patent DK-0980406-T3 (DK)
Inventor: GALE JEANNINE M
IPC: A61K8/37
Filed: 1998-04-24
Granted: 2002-04-02
Abstract: Colored lustrous pigments of superior quality are prepared by dry blending a metal oxide-coated mica nacreous pigment and a colorant lake with a blend adjuvant. The resulting blend exhibits a well dispersed, stable coloration, increased hydrophobicity and is particularly useful in cosmetic applications.
Patent ES-2294984-T3 (ES)
Title: Metodo de control direccional para dispositivo limpiador de piscinas.
Inventor: PORAT JOSEPH
IPC: E04H4/16
Filed: 2000-03-30
Granted: 2008-04-16
Abstract: Método de limpieza del fondo (51) de una piscina o depósito que comprende: (a) proporcionar un dispositivo de limpieza de piscinas robótico (10) que avance en la dirección de su eje longitudinal y que comprende un par de medios de tracción separados (14A, 14B) dispuestos en cada lado de su eje longitudinal y en cada extremo del dispositivo del limpieza (10), en el que los medios de tracción (14A, 14B) son seleccionados del grupo que consiste en: cepillos con forma de rodillos, cintas o ruedas de tracción sin fin, estando montado cada par de medios de tracción (14A, 14B) en cada lado del dispositivo de limpieza (10) permitiendo su rotación independiente, un motor de tracción separado (30A, 30B) conectado operativamente a cada par de medios de tracción (14A, 14B), un dispositivo de control programable (34), y uno o más sensores de pared generadores de señal (40; 40'') conectados a dicho dispositivo de control (34), siendo accionados dichos medios de tracción (14A, 14B) en cada lado del dispositivo de limpieza (10) por uno de dichos motores de tracción separados (30A, 30B), siendo dirigida la velocidad y/o dirección de rotación de cada uno de dichos motores separados (30A, 30B) por el dispositivo de control programable (34), siendo dicho controlador (34) sensible a las señales del sensor recibidas de uno o más sensores de pared (40, 40''); (b) activar el dispositivo de control (34) para poner en movimiento el dispositivo de limpieza (10) mediante la rotación de los medios de tracción (14A, 14B) a través del fondo (51) de una piscina o depósito, dirigiéndolo hacia una pared lateral (54, 54''); (c) interrumpir la rotación de los medios de tracción (14A, 14B) como respuesta a la señal del sensor de pared cuando dichos medios de tracción dispuestos en el extremo delantero o de avance del dispositivo de limpieza están próximos a una pared lateral (54, 54'') de la piscina o depósito; (d) invertir la dirección de rotación de dichos medios de tracción (14A, 14B) en un lado del dispositivo de limpieza (10) para producir de este modo un giro de 180º; (e) interrumpir la rotación de los medios de tracción (14A, 14B) cuando el extremo delantero del dispositivo de limpieza (10) en giro está próximo a la pared lateral (54, 54'') de la piscina o depósito; (f) activar los dos medios de tracción (14A, 14B) para desplazar el dispositivo de limpieza (10) alejándolo de la pared lateral (54, 54'') hacia otra pared lateral (54, 54''); y (g) repetir las etapas (c) a (f).
Patent ES-2272220-T3 (ES)
Inventor: BATES CECIL PETER
IPC: C21B13/04
Filed: 2000-07-04
Granted: 2007-05-01
Abstract: A procedure for starting up a direct smelting process for producing iron from a metalliferous feed material in a metallurgical vessel is disclosed. The vessel is of the type which includes a plurality of feed material injection lances/tuyeres (11, 13). The start-up procedure includes the steps of:      (a) preheating the vessel; (b) supplying a charge of molten iron to the vessel and forming a molten bath in the vessel,    (c) supplying carbonaceous material and flux to the molten bath and injecting oxygen-containing gas through one or more than one feed material injection lance/tuyere and combusting carbon and bath derived gas (if present) and thereby heating the molten bath and generating slag; and    (d) suppling metalliferous feed material to the vessel while continuing supply of carbonaceous material and flux and injection of oxygen-containing gas and smelting metalliferous feed material and producing molten iron and thereby completing the start-up procedure.    <IMAGE>
Patent ES-2223407-T3 (ES)
Inventor: SAKO YOICHIRO
IPC: G11B20/12
Filed: 2000-09-29
Granted: 2005-03-01
Abstract: A data record medium on which a digital signal has been recorded is disclosed, the digital signal being composed of main data and a sub code, the sub code having time information representing reproduction elapsed time, the sub code being recorded in association with the main data, wherein information that represents the reproduction elapsed time of the sub code is represented with a binary coded decimal number and address information in synchronization with the time information of the main data is represented with a binary number, the address information being contained in the main data. <IMAGE>