baber/WOPTO huggingface dataset:
Patent UY-25942-A1 (UY)
Title: Derivados de 7h-pirrolo (2,3-d)pirimidina, para compuestos intermedios, formulaciones farmacéuticas que los contienen y uso
Inventor: BOLD GUIDO
Filed: 2000-01-17
Abstract: Derivados de 7H-[2,3-d]pirimidina de fórmula (I), en donde: q es 0 o 1; n es de 1 a 3 cuando q es 0, ó n es de 0 a 3 cuando q es 1; R es halógeno, alquilo inferior, hidroxi, alcanoiloxi inferiro, alcoxi inferior, carboxi, alcoxi inferior-carbonilo, carbamoílo, N-alquilo inferior-carbamoílo, N,N-dialquilo inferior-carbamoílo, ciano, amino, alcanoílo inferior-amino, alquilo inferior-amino, N,N-dialquilo inferior-amino o trifluorometilo, siendo posible que cuando varios radicales R están presentes en la molécula, dichos radicales sean idénticos o diferentes; (a) R1 y R2 son ambos independientes uno del otro pudiendo ser fenilo sustituido, hidrógeno, piridilo sustituido o no; N-bencil-piridinio-2-ilo, naftilo, ciano, carboxi, alcoxi inferior-carbonilo, carbamoílo, N-alquilo inferior-carbamoílo, N,N-dialquilo inferior-carbamoílo, N-bencil-carbamoílo, formilo, alcanoílo inferior, alquenilo inferior, alqueniloxi inferior, o alquilo inferior sustituido; (b) cuando q es 0, uno de los radicales R1 y R2 es alquilo inferior no sustituido o fenilo no sustituido y el otro de los radicales R1 y R2 tiene uno de los significados que se dan anteriormente en el párrafo (a) con la excepción de hidrógeno; (c) R1 y R2 juntos son C4-C10-1,4-alcadienileno sustituido, ó (d) cuando q es 1, R1 y R2 son independientemente del otro alquilo inferior no sustituido o fenilo no sustituido o tienen uno de los significados que se dan anteriormente en el párrafo (a); y R6 es hidrógeno, alquilo inferior, alcoxi inferior-carbonilo, carbamoílo, N-alquilo inferior-carbamoílo ó N,N-dialquilo inferior-carbamoílo o una sal de los mismos, con la excepción del compuesto de fórmula (I) en el que n es 0, q es 1, R1 y R6 son los dos hidrógeno y R2 es metilo. Por ejemplo: 4-(3-cloro-anilino)-6-(pirid-2-il)-7H-pirrolo(2,3-d)pirimidina. La invención presenta compuestos intermedios nuevos para su preparación, formulaciones farmacéuticas que comprenden tales derivados y al uso de tales derivados para quimioterapia de tumores.
Patent UY-26548-A1 (UY)
Title: Glutarimidas sustituidas, su preparación, medicamentos que las contienen, y su uso de las mismas para la fabricación de medicamentos, especialmente inmunomoduladores, como asi también inhibidores de angiopatias y/o enfermedades hematologicas/oncológi
Inventor: GERMANN DR TIENO
Filed: 2001-01-19
Abstract: Glutarimidas sustituidas, su preparación, medicamentos que las contienen, y uso de las mismas para la fabricación de medicamentos, especialmente inmunomoduladores, como así también inhibidores de angiopatias y/o enfermedades hematológicas / oncológicas.
Patent UY-29798-A1 (UY)
Title: Derivados de carboxamida como antagonistas del receptor muscarínico
Inventor: WOOD ANTHONY
IPC: C07D211/44
Filed: 2006-09-18
Abstract: La invención se refiere a compuestos de fórmula a procedimientos e intermedios para su preparación, a su uso como antagonistas muscarínicos y a la composición farmacéutica que los contiene.
Patent UY-31100-A1 (UY)
Title: Derivados de espirociclopropilpiperidina, preparaciones y usos de los mismos
Inventor: GROBLEWSKI THIERRY
IPC: A61P37/00
Filed: 2008-05-22
Abstract: Se describe aquí al menos un derivado de piperidina, al menos una composición farmacéutica que comprende al menos un derivado de piperidina descrito aquí, y al menos un método para usar al menos un derivado de piperidina descrito aquí para tratar al menos una afección asociada con el receptor H3 de histamina.
Patent DZ-270-A1 (DZ)
Inventor: SER JASQUES
IPC: A61K9/50
Filed: 1981-02-25
Granted: 2004-09-13
Abstract: For the Contracting States : BE, CH, DE, GB, IT, LI, NL, SE 1. Process for coating at least one solid medicament active principle, slightly soluble in water and presented in a finely divided form, characterized in that the said active principle and an aqueous dispersion of one or more pharmaceutically acceptable solid hdyrophobic agents are mixed together under agitation, the said hydrophobic agent is made to flocculate by a physical or chemical means or a combination of these means, the active principle so coated is separated and dried. For the Contracting State : AT 1. Process for coating at least one solid medicament active principle, slightly soluble in water and presented in a finely divided form, characterized in that the said active principle and an aqueous dispersion of one or more pharmaceutically acceptable solid hdyrophobic agents are mixed together under agitation, the said hydrophobic agent is made to flocculate by a physical or chemical means or a combination of these means, the active principle so coated is separated and dried.
Patent DZ-1710-A1 (DZ)
IPC: C07D231/56
Filed: 1993-08-24
Granted: 2002-02-17
Abstract: Herbicidal compounds, compositions containing them, and a method for controlling weeds by application of the compositions are disclosed. The herbicidal compounds are 2-[(4-heterocyclic-phenoxymethyl)phenoxy]alkanoates of the formula   <IMAGE>   in which A is a derivative of an alkanoate bonded to the phenoxy oxygen at the alpha carbon, and Q is 4-difluoromethyl-4,5-dihydro-3-methyl-l,2,4-triazol-5(1H)-on-1-yl, 3,4,5,6-tetrahydrophthalimid-1-yl, 1-(1-methylethyl)imidazolidin-2,4-dion-3-yl, 1,4-dihydro-4-(3-fluoropropyl)-5H-tetrazol-5-on-1-yl, 3-chloro-4,5,6,7-tetrahydroindazol-2-yl, 4-methyl-l,2,4-triazine-3,5-dion-2-yl, 8-thia-1,6-diazabicyclo[4.3.0]-nonane-7-on-9-ylimino, or 1-methyl-6-trifluoromethyl-2,4-pyrimidinedione-3-yl; X is hydrogen, methyl, fluorine, or chlorine; Y is hydrogen; W is oxygen or sulfur; Z is hydrogen, fluorine, chlorine, bromine, lower alkyl, or methoxy; Z' is hydrogen, fluorine, or chlorine; and the group AO- may be in the 2, 3, or 4-position of the phenyl ring.
Patent ES-177992-A1 (ES)
Title: MEJORAS INTRODUCIDAS EN LAS EMULSIONES FOTOGRáFICAS FOTOSENSIBLES
Filed: 1947-05-12
Abstract: Mejoras introducidas en la preparación de una emulsión de sal de plata fotosensible en un aglutinante soluble en agua tal como gelatina que contiene un copulador de color caracterizadas por que el copulador de color se dispersa en la emulsión en forma de partículas líquidas finas distintas e insolubles en agua compuestas da una solución líquida del copulador de color en un compuesto orgánico de elevado punto de ebullición y virtualmente insoluble en agua.
Patent ES-179977-A1 (ES)
Title: UN DISPOSITIVO, CON UNA PARTE INDEPENDIENTE MONTADA ELáSTICAMENTE, QUE CONTIENE PARTES MoVILES A IMPULSAR DESDE EL EXTERIOR DE DICHA PARTE
Filed: 1947-10-02
Abstract: Un dispositivo con una parte especial dispuesta en forma elástica que constiene partes movibles a impulsar desde fuera de dicha parte caracterizado porque los medios de impulsión están conectados con dichas partes movibles pasando por un acoplamiento sujeto a la parte especial que transmite a las partes movibles la fuerza de impulsión aumentada.
Patent ES-180684-A1 (ES)
Title: Mejoras en sistemas de control de tono de aparatos radiorreceptores
Filed: 1947-11-27
Abstract: Mejoras en sistemas de control de tono de un aparato radio-receptor caracterizado porque el circuito de control de tono comprende un primer condensador ( C subíndice), un potenciómetro (R subíndice 3 ) y un segundo condensador (C subíndice 2) en serie, una de las placas de este segundo condensador (C subíndice 2) está conectada a las resistencias ( R subíndice 2, R subíndice 4) comprendidas en el circuito de regeneración invertido del amplificador de audio-frecuencia, en una forma tal que si el cursor del potenciómetro es movido en la dirección del primer condensador ( C subíndice 1), las frecuencias más altas en la banda de audición son interrumpidas y si el mencionado cursor está siendo movido en la dirección opuesta (de C subíndice 2) dicha acción de interrupción es reducida en primer lugar, luego totalmente cesada y finalmente invertida en una elevación de las mencionadas frecuencias más altas.
Patent ES-181414-A1 (ES)
Title: PERFECCIONAMIENTOS INTRODUCIDOS EN LA CONSTRUCCIoN DE LOS APARATOS DE FABRICACIoN DE LA CREMA HELADA
Filed: 1947-12-31
Abstract: Perfeccionamientos introducidos en la construcción de los aparatos de fabricación de crema helada, caracterizados por las particularidades siguientes, consideradas por separado o combinadas. a) Comprenden como único órgano de braceo, un tornillo sin fin que gira en el interior de una cámara cilíndrica del mismo diámetro que el tornillo y contiene la crema a congelar. b) La superficie de la espiral del tornillo está provista de pequeñas aberturas por las cuales se obliga la crema a pasar en dirección inversa a la del movimiento de traslación del tornillo, bajo la acción de la presión que provoca la rotación de dicho tornillo. c) El eje del tornillo sin fin está provisto de escurridores convenientemente dispuestos para retirar la crema que se adhiere en la pared interior del congelador, el cual perfeccionamiento tiene también por objeto contribuir al braceo de la masa cremosa. d) El sentido normal de rotación del tornillo sin fin, se invierte a voluntad mediante cualquier dispositivo mecánico apropiado, combinado con el mando de rotación de dicho tornillo. e) El aparato comprende un dispositivo para constituir un volante líquido de frio por medio de un volumen apropiado de salmuera, cuyo dispositivo se caracteriza porque la pared cilíndrica del congelador está constituida por una doble cubierta en la cual circula el líquido frigorífico, la cual pared está a su vez rodeada de un baño de salmuera contenido en una cuba o bien en una pared cilíndrica concéntrica con las otras dos paredes.
Patent ES-187235-A1 (ES)
Title: UN NUEVO SISTEMA DE FARO PARA AUTOMoVILES
Filed: 1949-02-26
Abstract: Nuevo sistema de faro para automóviles caracterizado porque comprender un foco reflector independiente del conjunto del faro el cual lleva empotrado el cristal exterior y forma un recipiente cerrado fuertemente presentando por su parte posterior un orificio para acoplar el portalámparas.
Patent ES-188145-A1 (ES)
Title: Aparato regulable para facilitar el corte de prendas de vestir
Filed: 1949-05-03
Abstract: Aparato regulable para facilitar el corte de prendas de vestir caracterizado por comprender un cierto número de elementos móviles perfilados al menos en parte y articulados entre sí de manera que puedan regularse cuyos elementos presentan al menos en parte escalas graduadas e índices de referencia para la regulación del perfil del aparato en correspondencia con las dimensiones de la pieza que se ha de cortar.
Patent ES-188171-A1 (ES)
Title: PERFECCIONAMIENTOS EN APARATOS DE CALEFACCIoN
Filed: 1949-05-11
Abstract: Perfeccionamientos en aparatos de calefacción caracterizándose porque funciona con aire caliente estando forrados por un doble chapa formando con la interior un doble fondo por donde circula el aire producido por un ventilador adiciona l siendo el combustible a emplear indistintamente carbón o leña.
Patent ES-198724-A1 (ES)
Title: UN PROCEDIMIENTO DE UNIoN DE LA GOMA AL METAL.
Filed: 1951-07-05
Abstract: Un procedimiento de unión a los metales y a las aleaciones metálicas de mezclas vulcanizables en caliente compuestos a base de goma natural o de una goma sintética, o de una mezcla de goma, caracterizado por las sucesivas aplicaciones sobre el metal perfectamente pulido de dos soluciones, denominadas respectivamente capa de adherencia y solución adhesiva y de un tratamiento térmico en presencia de aire o de otra mezcla de gas que contenga oxígeno, efectuando antes de la aplicación de la mezcla vulcanizable y de la vulcanización bajo presión del conjunto; estando la capa de adherencia exenta de goma y formada solamente por substancias de peso molecular relativamente pequeño, de las cuales al menos una esté dotada de afinidad para los metales, y conteniendo la solución adhesiva una o más gomas susceptibles de soldarse por vulcanización con la goma o las gomas existentes en la mezcla que deba fijarse al metal, al menos una substancia nitrogenada capaz de reaccionar con la substanciao las substancias dotadas de afinidad para los metales pudiendo haber eventualmente otros componentes de las dos soluciones, para formar una resina insoluble, infusible y adherente al metal, durante el citado tratamiento térmico.
Patent ES-252029-A1 (ES)
Title: Method of preparing hydrazine hydrate from dihydrazine sulfate
IPC: C01B21/16
Filed: 1959-09-14
Abstract: Hydrazine hydrate is prepared by saturating an aqueous solution, or suspension, of dihydrazine sulphate at below 20 DEG C. with NH3, separating ammonium sulphate, separating residual H2SO4 from the solution remaining either by saturating with NH3 under pressure, or by treating with an alkali metal hydroxide, e.g. NaOH, in amount at least stoichiometric to the H2SO4, and recovering N2H4.H2O by evaporation and rectification of the vapours. Alternatively, in a single operation the dihydrazine sulphate solution, or suspension, is saturated with NH3 under a pressure of 2-10 atms. at -20 DEG to 0 DEG C., (NH4)2SO4 is separated, and N2H4.H2O recovered from the solution. Where NaOH is used, the alkali metal sulphate may be removed by saturating with NH3, or by precipitation by addition of a volatile alcohol, e.g. methanol or ethanol, or by evaporation to dryness.
Patent ES-260154-A1 (ES)
Title: Improvements in or relating to the production of steroid compounds, and the compounds thus produced
IPC: C07J75/00
Filed: 1960-08-04
Abstract: The invention comprises 11b ,17a -dihydroxy-9a -fluoro- 16a -methyl- 21-diiodo-pregna1, 4-dien-3,20-dione, 11b ,17a -dihydroxy-21-diiodo-pregn-4-en-3,20-dione, 11b ,17a -dihydroxy-21-diiodo-pregna-1,4-dien-3,20-dione and processes for the production of 21-diiodo derivatives of 20-keto steroids of the pregnane and allopregnane series, in which the starting steroid is a steroid of the pregnane or allopregnane series having a 20-ketone substituent which is reacted directly with iodine in the presence of calcium chloride and calcium oxide to form the desired 21-diiodo compound, the reaction being effected in a liquid reaction medium which is solvent for the starting material and substantially non-solvent for the 21-diiodo product or a solvate thereof formed with a liquid component of the reaction medium. A solvate formed with carbon tetrachloride is insoluble in methanol. Subsequently the 21-diiodo derivative may be reacted with an alkali metal acylate in an inert organic solvent to convert it into the corresponding 21-monoacyloxy compound. The 20-keto-20-diiodo derivative is isolated by filtering the reaction medium, dissolving the filtered solids in dilute aqueous acid to remove the calcium compounds and finally isolating the 20-keto-2-diiodo derivative by filtering and/or centrifuging. Specifications 843,211, 877,227 and 934,701 are referred to.
Patent ES-291550-A1 (ES)
Title: An improved yarn package wound on a bobbin
IPC: D01H1/38
Filed: 1963-09-11
Abstract: A yarn package 4 is wound on a bobbin 3 and two distinct bundles 8, 11 are wound one at either end of the bobbin, the lower bundle 8 serving to secure a transfer tail wound under the bundle and the upper bundle 11 including the starting end of the thread which is secured against the bobbin by a removable clamping device. With the bobbin 3 mounted on a spindle 1 in a draw-twisting machine and with a ring traveller in the position a an initial waste portion 6 of yarn is wound on the spindle 1. The ring is raised to position b forming a loop 7 which passes over the transfer rim 2 and further turns 8 are wound at the lower end of the bobbin before the ring is raised to the position c leaving about three spaced turns 9 wound about the bobbin. The ring is traversed in the normal manner between positions c and d to build a package 4 and then raised to position e to form the upper bundle 11. The cycle of operations is complete by lowering the ring to the position a thereby forming a steeply inclined turn 12. The turn 12 is cut at the point where it crosses an annular groove 13, the tail end 15 placed in the bore of the bobbin and a removable clamping device (Figs. 3, 4, and 5 not shown) placed on the end of the bobbin to hold the end 15. The wound bobbin is next doffed, in the course of which the loop of yarn 7 catches in a notch 14 in the transfer rim and becomes severed thereby, leaving a short tail of yarn extending from under the bundle 8. Axial grooves 19 in the lower end of the bobbin facilitate cutting through the bundle 8 to leave the turns 9 available for piecing to another package.
Patent ES-302220-A1 (ES)
Title: Improvements in and relating to alarm apparatus
IPC: G08B25/10
Filed: 1964-07-17
Abstract: An alarm signal is automatically transmitted by radio when an alarm condition occurs, removal of the condition not ending the signal. The radio signal may be a tone or a coded sequence of tones, modulated on to a carrier.
Patent ES-306442-A1 (ES)
Title: Improvements in or relating to liquid level gauges
IPC: G01F23/42
Filed: 1964-11-26
Abstract: In a gauge for indicating the liquid volume delivered to, dispensed from and contained in a container a float 27, forming a close fit in a chamber 48 in restricted communication through an aperture 46 with the liquid, drives two indicating devices 20, 21 through the intermediary of gears 24, 25 and a helical head 28 mounted on a shaft 26 or perforated strip, Figs. 5 and 6 (not shown) or a helical strip, Fig. 4 (not shown). The indicator 20 is driven through a unidirectional drive 23 and records the total amount of liquid supplied to the tank 37 and the indicator 21 indicates the actual volume of liquid remaining in the tank 37. A horizontally movable disc Figs. 7 to 9 (not shown) is arranged to open or close the aperture 46. Devices are described to prevent siphoning of the tank and to give a very accurate indication of the liquid level, Figs. 10 to 14 (not shown).
Patent ES-313713-A1 (ES)
Title: Apparatus for maintaining a plurality of chromatography plates in co-planar relationship
IPC: G01N30/93
Filed: 1965-06-02
Abstract: Apparatus for maintaining a plurality of juxtaposed plates in co-planar relationship for coating, comprises movable locating members 8 for engaging marginal portions of the upper planar surface of each of a plurality of plates 6, opposed resilient means 5 for supporting the plates and ancillary means for causing the guide members 8 to sandwich the plates 6 against the resilient means 5 under pressure at the marginal portions, to maintain the upper planar surfaces in co-planar relationship. As shown the locating members 8 are U-shaped having one arm longer than the other, the longer being pivotally connected at 21 to a number of transverse members 17. Each member 17 has associated therewith a cam 13 fixed to shaft 11. In operation with the cams 13 in the position shown in Fig. 3 (not shown) plates 6 are positioned on the resilient means 5 which may consist of two parallel strips of polyurethane foam or foam rubber. The members 8 are then pivoted into their operative position and the shaft 11 turned through 180 to Fig. 2 position so that the members 8 press down on the marginal portions of plates 6 such that their upper surfaces are in register. After coating the members 8 are released and the plates removed. In an alternative embodiment the two guide members 8 are mounted on overhead transverse members which are pivoted at one side of the apparatus and may be locked in a horizontal position by locking means on the other side. In another embodiment two spindles are used to raise and lower the members 8, there being a suitable arrangement of cams so that on rotation of one of the spindles both spindles lift the members 8 upwardly and outwardly from the plates 6.
Patent ES-318420-A1 (ES)
Title: Terminal block mounting
IPC: H02B1/052
Filed: 1965-10-13
Abstract: A terminal block 10, is mounted on a rail 12 by exerting a force in the direction F4 shown in the Figure. The block is made of a flexible material, and at its lower end is formed with projections 14 and 18. Projection 18 is separated from the main body by a V-shaped slot 20, and has a convex outer surface. Flange 34 of the rail 12 is inserted above projection 14 and as a force is exerted flange 36 rides along the outer surface of projection 18 flexing said projection until it passes point 24 when the projection moves outwardly again until the flange 36 abuts surface 32 on the lower part of the main body. A slider 26 may clip over the outer surface of flange 18. If the terminal block is to be mounted in an aperture in a board, a flange is provided which extends outwardly of the main body portion and snaps into position behind the board.
Patent ES-337637-A1 (ES)
Title: Tool engaging device
IPC: B23Q3/157
Filed: 1967-03-06
Abstract: A machine tool for drilling &c. comprises a rotary tool spindle 13, a store of tool-carrying arbors 14, means 26 for moving an arbor on to a plate 28, which supports the tool during cutting, and means for moving the plate so that a shank 15 on the arbor enters a recess in the spindle and projections or recesses 16, 34, 34a on the arbor and spindle inter-engage. The arbors are mounted on carriers 23 carried around a track 21 by a chain 24. The transporter 26 includes an hydraulicallyoperated finger. The plate 28 contains rollers or re-circulating balls 29 to support the tool flange 18, and also carries spring-pressed retaining rollers 30. The tool is raised into driving engagement with the spindle by an hydraulically-operated slide 31. A lower flange 35 may be provided on a tool to ensure positive withdrawal from the spindle.
Patent ES-340677-A1 (ES)
Title: Solid oral drug medicament coated for rapid or gradual release with copolymers of polymerizable quaternary ammonium monomers and water-insoluble homopolymer-forming monomers
IPC: A61K9/28
Filed: 1967-05-18
Abstract: Pharmaceutical compositions for oral administration comprising discrete units of pharmacologically active material are provided with at least one coating which releases the active material in the digestive tract, the coating comprising a copolymer of at least one ethylenically unsaturated monomer capable of forming a water-insoluble homopolymer, at least one quaternary ammonium compound and, if desired, at least one further copolymerisable monomer, the monomers being selected to provide a copolymer having solubility and permeability characteristics which are substantially independent of physiological pH values. Suitable unsaturated monomers include the esters of acrylic and methacrylic acid, styrene and its homologues, vinyl esters and vinyl chloride. Suitable quaternary ammonium compounds include quaternised aminoalkyl esters or aminoalkyl amides of acrylic or methacrylic acid e.g. #-methacryloyloxyethyltrimethylammonium methosulphate, #-acryloyloxypropyltrimethylammonium chloride or trimethylamino-methylmethacrylamide methosulphate. The quaternary nitrogen atom may also be a member of a heterocyclic ring, e.g. methacryloyloxyethylmethyl morpholinium chloride or the corresponding pyridinium salt, or it may be bonded to the acrylic or methacrylic group by means of a group interrupted by a hetero atom e.g. a polyglycol ether group. Quaternised vinyl-substituted nitrogen-containing heterocyclic compounds such as methylvinyl pyridinium salts, vinyl esters of quaternised aminocarboxylic acids and styryl trialkylammonium salts may also be used The solubility of the coating may be modified by the addition of suitable monomers such as acrylamide, methacrylamide, hydroxy-alkyl esters of acrylic or methacrylic acid and vinyl pyrrolidone.