Patent SG-11201804038V-A (SG)
Title: Conditionally active heterodimeric polypeptides and methods of use thereof
Inventor: TAUNTON JOHN W
IPC: C07K14/705
Filed: 2017-01-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date ;.; ; ....r, ;„: 13 July 2017 (13.07.2017) WIP0 I PCT (10) WO International Publication Number 1111111111131111111111111111111111113111111111111111111111111111311111111111111 2017/120546 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 38/00 (2006.01) C07K 14/435 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 38/16 (2006.01) C07K 14/705 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07K 14/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/012634 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 6 January 2017 (06.01.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/276,725 8 January 2016 (08.01.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: THE REGENTS OF THE UNIVERSITY TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Floor, Oakland, California 94607 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: TAUNTON, John W.; 600 16th Street, San LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Francisco, California 94158 (US). LIM, Wendell A.; 600 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 16th Street, San Francisco, California 94158 (US). WU, Chia-Yung; 1 Hawthorne St., Unit 4F, San Francisco, Published: California 94105 (US). 21(3)) — with international search report (Art (74) Agent: GUEDELHOEFER, Otto C.; 201 Redwood with sequence listing part of description (Rule 5.2(a)) Shores Parkway, Suite 200, Redwood City, California 94065 (US). Title: CONDITIONALLY ACTIVE HETERODIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF (54) FIG. - IA Min eralocorticoid receptor (Horn o sapiens) 1 metkgyhsip egicimerrvg qvso s averss lgptertden n\".reivnv sc vagaiprnst 61 Ipc_gqdnn: eleskelsat vaesmgiymd Svro..aqysye usskeklei paA:sdikt 121 TIncicyjsrftsp akiycinveql vktykgnihr. pstiscvvrksp Irstrusdsgs svnggvmrav 181 vksPimchek spsvcspInn tasvcspagi nsyssttasf qafpvhspit qgtpitospn 241 venrgsrshs pahasnvgsp lsspissmks sisspQshos vkspvsspnn vtlrssyssp 301 aninnsresv sspsntnnrs tisspaastv gsicspvnna fsrasgtsa gsstirdvvp spdtqekgaq evpfpkteev esaisrvtg giniv . clyikp epdgafsssc lggnskinsd ssfsvpikqe stThscsgts fkgnptvnpf pfmdgsyfsf rddkdyysis gilippypgf 481 dgncegsgfp vgikqepddg syypeasips saivgvnsqg qsfhyrigaq gtisisrsar 541 dcisfghlssf , ppvnt_vesw kshgdissrr sdgypvleyi penvssstIr systgssrps 601 kiclvcgdea sgohygvvtc gsckvffkra vegOnylca grndoilaKi. rrThcpacr]. I'l .4t 661 gkolgagani garkskkigk 1.0ihees.pq gqgpppp.ppp pqspeegtiy iapakqpsvn 721 talpqlati sraltpapm vle:iepetv yagydaskpd :aenlistin taagi“giqv 721 vtwakvLogf knipledgit. licuswmas sfalswrsyk htnsgflyfa pdivfneekm 1 1' 41 hqsam:iql co gmhclisiory rigitteeyt ilycKv1 i , 1st ipkiO 4 scla afeev4tnyi un 901 kelrkmvticc pnnsggswgr fygitklids mhdivsdlre fcfytfresh alkvefpami O 961 velisdclipk vesgnakply fhrk el 11 ..„.„ N 1-1 (57) : The present disclosure provides conditionally active, heterodimeric polypeptides. The conditionally active, heterodi - 0 meric polypeptides are active in the presence of a dimerizing agent that induces dimerization of the polypeptides of the heterodimer. \" A conditionally active, heterodimeric polypeptide of the present disclosure is useful in a variety of research and treatment methods, 0 which are also provided.