baber/WOPTO huggingface dataset:
Patent CA-3157657-A1 (CA)
Title: 1,2,4-oxadiazole derivatives as liver x receptor agonists
Inventor: BOSS KELLY D
IPC: C07D413/06
Filed: 2020-11-23
Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I'), or pharmaceutical composition described herein.
Patent CA-3158859-A1 (CA)
Inventor: EICK PETER M
IPC: G01V1/28
Filed: 2011-06-08
Abstract: Linvention concerne une disposition pour lacquisition sismique caractérisée en ce que lespacement entre chacune des paires adjacentes de lignes de récepteurs et de sources nest pas uniforme. Certains espacements entre les lignes de récepteurs et/ou de sources et/ou entre les récepteurs et/ou les sources sont plus importants et dautres sont plus réduits, pour donner une reconstruction de meilleure qualité du champ dondes en couvrant une superficie totale supérieure ou similaire dacquisition de données sismiques tout en donnant un champ dondes échantillonné de façon optimale par les récepteurs et les sources de telle sorte que la reconstruction du champ dondes réponde à des besoins dimagerie du sous-sol.
Patent CA-3159258-A1 (CA)
Title: Adhesive photoprotective compounds and uses thereof
Inventor: POULETTY PHILIPPE
IPC: C07C317/18
Filed: 2020-12-18
Abstract: The present invention relates to a compound represented by the following formula (I): A[B-(C)v]w, wherein A is a photoprotective moiety, B is a linker, C is a functional group, v is an integer from 1 to 2000, and w is an integer from 1 to 6. It also relates to a composition comprising the same and, more particularly, to a cosmetic or a sunscreen composition. It also relates to the use of such compounds in cosmetic and therapeutic applications. The invention also relates to the use of such compounds for reducing photodegradation and/or photoinstability of pharmaceuticals and cosmetics. The invention further relates to a material comprising a support and such a compound adhered to said support.
Patent CA-3163311-A1 (CA)
Title: Compositions multimodales de fluor-cy3/5/7-dota-haptene, diagnostic, chirurgie et radioimmunotherapie guidees par fluorescence
Inventor: CHEUNG NAI-KONG V
IPC: A61K31/69
Filed: 2020-12-30
Abstract: La présente invention concerne des compositions et des procédés pour la détection et le traitement du cancer. En particulier, les compositions de la présente invention comprennent des compositions multimodales à base de fluor-cyanine-DOTA-haptène qui peuvent être complexées avec un radio-isotope (par ex., 175Lu). L'invention concerne également des procédés d'utilisation des compositions de fluor-cyanine-DOTA-haptène de la présente technologie dans l'imagerie diagnostique ainsi que la radioimmunothérapie préciblée.
Patent CA-3163931-A1 (CA)
Inventor: SPORSTOL SIGVE
IPC: B01J20/10
Filed: 2020-12-09
Abstract: Stationary phase for preparative High Pressure Liquid Chromatography (HPLC) for preparative separation of Rare Earth Elements (REEs), the stationary phase comprising porous particles suitable for HPLC having a non-polar surface being impregnated with ligands binding REEs, wherein the porous particles has a pore size of 300 Å or higher, is described.
Patent CA-3164298-A1 (CA)
Inventor: Fjeldheim Ivar
IPC: B65G1/04
Filed: 2021-01-27
Abstract: A measuring system for monitoring atmospheric conditions in an automated storage and retrieval system having a three-dimensional storage grid structure (104) for storing storage containers (106), wherein at least one container handling vehicle (201, 301) has a container handling platform (500) with a first set of grippers for handling the storage containers (106), the measuring system is housed in a box-shaped measuring unit (501) having same size and features as a storage container (106), where the box-shaped measuring unit (501) comprises measuring equipment for measuring at least one atmospheric condition, a transmitter for transmitting the measurements to a computer system, at least one rechargeable power source and a data recorder for recording measurement data, wherein the box-shaped mesuring unit (501) comprises at least one piece of measuring equipment on each side of the box-shaped measuring unit (501).
Patent CA-3164533-A1 (CA)
Title: Procede d'etalonnage d'un accessoire d'un engin de chantier
Inventor: SHARMA AMIT
IPC: E02F9/26
Filed: 2021-01-20
Abstract: Un dispositif de commande peut obtenir des premières données relatives à une pluralité de positions d'un accessoire d'un engin de chantier pendant une première période de temps et peut déterminer, sur la base des premières données, une première valeur de bruit relative à au moins une vitesse de l'accessoire pendant la première période de temps. Le dispositif de commande peut obtenir des secondes données relatives à une pluralité de positions de l'accessoire pendant une seconde période de temps et peut déterminer, sur la base des secondes données, une seconde valeur de bruit associée à au moins une vitesse de l'accessoire pendant la seconde période de temps. Le dispositif de commande peut déterminer, sur la base de la première valeur de bruit et de la seconde valeur de bruit, un début de mouvement de l'accessoire. Le dispositif de commande peut provoquer, sur la base de la détermination du début de mouvement de l'accessoire, l'étalonnage de l'accessoire.
Patent CA-3164922-A1 (CA)
Title: Oligomere hydrophobe a faible temperature de transition vitreuse ayant un niveau eleve d'agent de transfert de chaine
Inventor: PASTENA GIANNA
IPC: C09D7/65
Filed: 2020-12-09
Abstract: L'invention concerne un additif pour une composition de peinture ou de coloration ou pour une composition de colorant. L'additif est polymérisé à partir d'au moins un monomère d'acrylate et un agent de transfert de chaîne. L'additif a un poids moléculaire pondéral d'environ 2000 Daltons à environ 5000 Daltons, et l'agent de transfert de chaîne comprend une fonctionnalité hydrogène-soufre et est présent dans environ 8 à environ 20 parties pour cent parties de monomères. La température de transition vitreuse de l'additif est comprise entre environ -50 °C et environ -10 °C et l'additif est hydrophobe. L'additif est ajouté à la composition de colorant pour réduire au minimum le séchage à l'embout au niveau des cartouches de colorant, et est ajouté à la composition de peinture ou de coloration en tant qu'agent d'extension de temps d'ouverture.
Patent CA-3166233-A1 (CA)
Title: Alpha-amylase variants and polynucleotides encoding same
Inventor: ELLIOTT SARAH SCHULTHEIS
IPC: C12N9/18
Filed: 2021-02-09
Abstract: The present invention relates to isolated alpha-amylase variants of a parent alpha-amylase, comprising an alteration at one or more positions corresponding to positions 196, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 28, 38, 39, 43, 54, 56, 57, 64, 67, 68, 70, 71, 86, 89, 90, 94, 96, 99, 101, 103, 107, 108, 110, 113, 114, 117, 127, 134, 138, 142, 150, 151, 152, 156, 169, 171, 174, 179, 183, 193, 199, 200, 204, 205, 207, 208, 209, 212, 218, 221, 222, 224, 233, 241, 245, 259, 275, 278, 281, 282, 283, 284, 285, 308, 323, 335, 348, 359, 382, 386, 388, 392, 394, 396, 412, 414, 417, 424, 428, 457, 459, 466, 479, 489, 511, 533, 534, 542, 543, 545, 547, 549, 550, 551, 560, 566, 570, 574, 575, 576, 577, 578, 580, 581, 582, 589, 592, 599, 603, 605, 608, 614, 619, or 626 of the polypeptide of SEQ ID NO: 1, wherein the variant has alpha-amylase activity and wherein the variant has at least 60%, e.g., at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity, but less than 100% sequence identity, to the polypeptide of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. The alpha-amylase variants of the invention have increased stability at pH 4.0 and 32°C compared to the parent alpha-amylase.
Patent CA-3166971-A1 (CA)
Title: Flexible punch and weld system
Inventor: YAMAMOTO HIDEKI
IPC: G05B19/418
Filed: 2021-02-04
Abstract: A flexible assembling system incorporating at least one manufacturing cell including at least one universal fixture, at least one position monitoring device (e,g., monitoring system, 3D vision system, 3D vision system / scanner, artificial intelligence position determination and monitoring, artificial intelligence vision system to locate part or a feature(s) of the part, and combinations thereof), and at least one programmable robot or machine (e.g., punch, weld, etc.). The at least one universal fixture is a non- dedicated fixture such that the fixture is usable with various products and not dedicated to only one specific part being manufactured.
Patent CA-3167949-A1 (CA)
Inventor: MAETSCHKE STEFAN
IPC: G06T7/00
Filed: 2021-04-28
Abstract: A method for real-time detection and correction of shadowing in hyperspectral retinal images may include capturing receiving, using a processor, a hyperspectral image of a retina of a patient, detecting, by the processor, a shadow in the hyperspectral image, determining, by the processor that the shadow of the hyperspectral image exceeds a threshold, and in response to determining that the shadow of the hyperspectral image exceeds the threshold, initiating, using the processor, a capture of an additional hyperspectral image of the retina of the patient. Various other methods, systems, and computer-readable media are also disclosed.
Patent CA-3170621-A1 (CA)
Inventor: ROSA-CALATRAVA MANUEL
IPC: A61K31/706
Filed: 2021-03-10
Abstract: The present invention relates to a pharmaceutical composition comprising Diltiazem in a suitable pharmaceutical carrier for its therapeutic use in the prevention and/or treatment of a viral infection caused by the SARS-CoV-2 virus, referred to as COVID-19 disease.
Patent CA-3171650-A1 (CA)
Inventor: ADLER MARK A
IPC: A61B5/02
Filed: 2021-02-17
Abstract: A system that provides an independent and agnostic cardiovascular sensing ability that can be deployed prior to the standard treatment methods for blocked cardiovascular arteries, and placed in the zone of a vascular lesion for treatment, placing sensors that can monitor blood and vessel specificity to manage the acute and long term biologic reaction to the treatment zone communicating information for analytical management and decision processing to an external or internal receiving station.
Patent CA-3172202-A1 (CA)
Title: Tcr a haute affinite pour reconnaitre un antigene afp
Inventor: LI YI
IPC: C07K14/725
Filed: 2021-03-19
Abstract: L'invention concerne un récepteur des lymphocytes T (TCR) qui peut se lier à un complexe KWVESIFLIF-HLA A2402, l'affinité de liaison de celui-ci étant au moins 2 fois celle d'un TCR de type sauvage. L'invention concerne en outre une molécule de fusion du TCR avec un agent thérapeutique, ladite molécule de fusion ciblant une cellule tumorale présentant le complexe KWVESIFLIF-HLA A2402.
Patent CA-3174189-A1 (CA)
Inventor: KLIEBER JOCHEN
IPC: B62K21/10
Filed: 2022-09-15
Abstract: The invention describes an apparatus for providing a steering moment for a two-wheeler steering mechanism, with a mounting device for mounting the apparatus on a two-wheeler frame, a coupling device for coupling the apparatus with the two-wheeler steering mechanism and an actuator device for causing a steering force, in particular a restoring force, that is transmittable to the two-wheeler steering mechanism via the coupling device, wherein the actuator device comprises a control interface for controlling the actuator device by a steering control device.
Patent CA-3176280-A1 (CA)
Title: Pneumatic latch clamp
Inventor: RENTZ MATTHEW
IPC: B25B5/16
Filed: 2022-09-22
Abstract: A power clamp includes a body. A piston assembly is coupled with the body.  The piston assembly includes an actuation mechanism and a movable piston rod.  A  linkage is housed in the body. The linkage is movably coupled with the piston rod. A  plunger is movably coupled with the linkage. A clamp hook is coupled with the plunger for clamping a workpiece. The linkage moves the clamp hook between a release and clamping position.
Patent CA-3177229-A1 (CA)
Inventor: ONG SHAOWEI
IPC: C07J1/00
Filed: 2018-08-30
Abstract: Testosterone ester triglyceride formulations, optionally further including adducts.  Methods of in-situ control of the manufacture or fomiation of such adducts are also described.
Patent CA-3177927-A1 (CA)
Title: Anti-igsf1 antibody and use thereof
Inventor: KIM SEONG-RAK
IPC: C12P21/08
Filed: 2021-08-20
Abstract: The present invention relates to a novel antibody that specifically binds to IGSF1 and a pharmaceutical composition for preventing or treating cancer, comprising the same as an active ingredient. Specifically, the present invention provides an antibody that binds to the C-terminus of IGSF1. The anti-IGSF1 antibody according to the present invention exhibited high specificity and high binding capacity to IGSF1. The anti-IGSF1 antibody according to the present invention increased the infiltration of immune cells in the spheroids when lung cancer cell spheroids in which IGSF1 is overexpressed were co-cultured with human peripheral mononuclear cells. In addition, the anti-IGSF1 antibody according to the present invention inhibited tumor growth in a humanized mouse transplanted with human lung cancer cells in which IGSF1 is overexpressed, and increased the expression of cytokines in tumor tissues. Through the above results, it was confirmed that the anti-IGSF1 antibody may inhibit tumor growth by increasing the infiltration of immune cells into lung cancer tissues in which the IGSF1 expression is increased, and immune response. Therefore, the anti-IGSF1 antibody may be utilized as an anticancer agent for effectively treating cancer in which IGSF1 is overexpressed.
Patent CA-3179001-A1 (CA)
Title: Systems and methods for applying reduced pressure therapy
Inventor: FOWLER ALEX
IPC: A61M1/00
Filed: 2014-11-19
Abstract: Embodiments of a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a. pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can he fluidicaily connected to facilitate delivery of negative pressure to a wound. The pump assembly can present graphical user interface screens for controlling and monitoring delivery of negative pressure. The system can be configured to efficiently deliver negative pressure and to detect and indicate presence of certain conditions, such as low pressure, high pressure, leak, canister full, and the like. Monitoring and detection of operating condition can be performed by measuring one or more operational parameters, such as pressure, flow rate, and the like.
Patent CA-3179023-A1 (CA)
Title: Systems and methods for treated exhaust gas recirculation in internal combustion engines
Inventor: SCHICKLER JOHN FRANCIS
IPC: F02M26/46
Filed: 2020-04-08
Abstract: Systems and methods for treated exhaust gas recirculation (EGR) for an internal combustion engine are disclosed. The internal combustion engine has an exhaust manifold discharging exhaust gas and an intake manifold receiving forced air from a compressor. One or more exhaust treatment devices treat the exhaust gas and produce a treated exhaust gas. The EGR system includes an EGR line downstream of the one or more exhaust treatment devices and connected to the engine intake line downstream of the compressor, wherein the treated EGR line recirculates the treated exhaust gas to the intake manifold of the engine without passing through the compressor.
Patent CA-3182193-A1 (CA)
Inventor: GROTH ROBERT PAUL
IPC: F26B19/00
Filed: 2020-11-16
Abstract: A harvesting system includes at least one modular unit coupled to a harvester includes a drying unit to dry a harvested material introduced into the harvester including at least one rotating drum, a number of appendages extending from the at least one rotating drum, at least one sensor to determine at least one environmental state within the drying unit, and at least one environmental state adjustment device to adjust at least one environmental attribute within the drying unit. The modular unit also includes a collection unit to collect the harvested material into a unit, a first conveyor mechanism to convey the harvested material from the drying unit to the collection unit, and a control system to control at least the harvester, the drying unit, the collection unit, the first conveyor mechanism, the sensor, and the environmental state adjustment device based on a signal received from the at least one sensor.
Patent CA-3182470-A1 (CA)
Title: Methods and apparatus to determine impressions using distributed demographic information
Inventor: MAZUMDAR MAINAK
IPC: H04L67/1396
Filed: 2011-09-21
Abstract: Example methods and apparatus to determine impressions using distributed demographic information are disclosed. A disclosed example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged.
Patent CA-3188373-A1 (CA)
Inventor: LAZERWITH SCOTT E
IPC: C07D487/04
Filed: 2021-08-23
Abstract: L'invention concerne des composés et des procédés d'utilisation desdits composés, seuls ou en association avec d'autres agents, et des compositions pharmaceutiques desdits composés pour le traitement d'infections virales. Formule (I)
Patent CA-3188478-A1 (CA)
Inventor: LEONG KAM
IPC: A61K51/06
Filed: 2021-08-16
Abstract: L'invention concerne un système nanoparticulaire permettant d'administrer des agents de traitement, qui peut être utilisé, par exemple, pour traiter une inflammation, ou pour traiter un cancer, tel qu'un cancer buccal, et une inflammation associée. Le système utilisé de cette manière fournit une solution au cancer buccal et à sa métastase associée en fournissant une thérapie ciblée permettant d'administrer des agents chimiothérapeutiques. Le système nanoparticulaire se présente sous la forme de nanoparticules de polyamidoamine-G3 modifiées par le cholestérol (NP de PAMAM-Chol), qui sont utilisées en tant que véhicule d'au moins un médicament. Ledit médicament peut comprendre au moins un médicament anticancéreux, au moins un corticostéroïde, au moins un stéroïde anabolique, au moins une hormone (naturelle ou synthétique), et certaines de leurs combinaisons.
Patent CA-3191375-A1 (CA)
Title: Aqueous adhesive composition comprising a thermosetting resin having improved stability
Inventor: DOISNEAU DAVID
IPC: C09J161/12
Filed: 2021-09-28
Abstract: The present invention relates to an aqueous adhesive composition, comprising a thermosetting resin based on: -at least one aromatic compound A1 including at least one aromatic ring bearing at least two functions, one of said functions being an aldehyde function or a hydroxymethyl function, the other being an aldehyde function or a hydroxymethyl function; -at least one aromatic polyphenol A2 including at least one aromatic ring bearing at least two hydroxyl functions in the meta position relative to one another, the two ortho positions of at least one of the hydroxyl functions being unsubstituted; and -at least one organic compound G selected from the group consisting of the monosaccharides G1 or the oligosaccharides G2. Such an adhesive composition can be used, in particular, for assembling wooden elements.
Patent CA-3192137-A1 (CA)
Inventor: BESSARABOV GEORGIEVICH DMITRI
IPC: B01J23/42
Filed: 2021-09-13
Abstract: La présente invention concerne un catalyseur de déshydrogénation. Plus particulièrement, mais pas exclusivement, la présente invention concerne des catalyseurs de déshydrogénation comprenant du platine, le siliciure de platine et/ou le phosphure de platine étant supportés sur divers supports d'oxyde métallique, qui peuvent également être des supports d'oxyde métallique modifiés, pour la déshydrogénation d'un support d'hydrogène organique liquide.
Patent CA-3192456-A1 (CA)
Title: Single domain antibodies
Inventor: HUO JIANDONG
IPC: A61P31/14
Filed: 2021-09-14
Abstract: The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits.
Patent CA-3193112-A1 (CA)
Title: Arng ciblant le gene ctgf et son utilisation
Inventor: LIANG JUNBIN
IPC: C12N15/09
Filed: 2021-05-25
Abstract: L'invention concerne un ARNg pouvant diriger une enzyme Cas pour cibler un gène CTGF et leur utilisation, appartenant au domaine technique de l'édition de gènes. L'ARNg peut diriger l'enzyme Cas pour qu'elle effectue un clivage ciblé sur une région du site de liaison SMAD d'un promoteur du gène CTGF, ou l'ARNg peut diriger l'enzyme Cas pour qu'elle effectue un clivage ciblé sur une région de l'exon 2 du gène CTGF. L'ARN gARN peut réduire la surexpression du gène CTGF humain Par L'Intermédiaire d'un système d'édition de gène CRISPR-Cas. L'ARNg susmentionné peut réduire la surexpression du gène CTGF humain via un système d'édition de gènes CRISPR-Cas.
Patent CA-3193403-A1 (CA)
Inventor: FUSARELLI PETER
IPC: C05F17/50
Filed: 2021-09-21
Abstract: La présente invention concerne un procédé de traitement de déchets organiques, le procédé comprenant les étapes consistant à : - traiter une quantité de déchets organiques à l'aide d'un procédé de digestion anaérobie; puis - traiter au moins une partie du produit provenant du procédé de digestion anaérobie à l'aide d'un procédé de lombriculture, ce qui entraîne la production de produits solides et liquides d'engrais.
Patent CA-3195692-A1 (CA)
Inventor: TATKOV STANISLAV
IPC: A61M16/16
Filed: 2010-12-22
Abstract: The invention is directed to a user interface and a method of supplying breathing gas. The interface comprises a pair of non-sealing nasal prongs configured to deliver a flow of breathing gas to a user's nares, a mask arranged about the nasal prongs, a resilient sealing member configured to form a seal with a user's face to allow pressurisation of the user's respiratory system, and a gas outlet in the mask.  The nasal prongs have a sufficient bore to supply a gas flow rate in excess of an intended user's peak inspiratory flow rate.