baber/WOPTO huggingface dataset:
Patent IE-33502-L (IE)
Title: Analgesic composition
IPC: A61K31/445
Filed: 1969-07-31
Abstract: 1,250,582. Analgesic compositions. ELI LILLY & CO. 14 Aug., 1969 [15 Aug., 1968 (2)], No. 40770/69. Heading A5B. An analgesic composition comprises a narcotic analgesic agent and a 3- or 4-phenoxyphenylalkanoic acid potentiating agent of the formula or a pharmaceutically acceptable salt thereof, wherein (a) the phenoxy moiety is in the 3- position, R<SP>3</SP> is methyl or ethyl and R<SP>4</SP> is hydrogen, (b) the phenoxy moiety is in the 4-position, R<SP>3</SP> is hydrogen or methyl and when R<SP>3</SP> is hydrogen R<SP>4</SP> is hydrogen, fluoro, ethyl, methyl or methoxy and when R<SP>3</SP> is methyl R<SP>4</SP> is hydrogen. The narcotic analgesic agent may be codeine, morphine, methadon, meperidine, versidyne [1 - (p - chlorophenethyl) - 6,7 - dimethoxy - 2 - methyl - 1,2,3,4 - tetrahydroisoquinoline] or m - (1 - methyl - 3 - propyl - 3 - pyrrolidinyl) phenol. The phenoxyphenyl compound may be in the form of the Na, K, Ca, Mg, ammonium or benzylammonium salt. Preferred phenoxyphenyl compounds include 2 - (3 - phenoxyphenyl) propionic, 2 - (3 - methyl - 4 - phenoxyphenyl) acetic, 2 - (3 - phenoxyphenyl) butyric and 2 - (4 - phenoxyphenyl)- propionic acids. The compositions may be administered orally as tablets, pills, powders, granules, capsules, emulsions, solutions, suspensions, syrups, and elixirs; parenterally in the form of sterile aqueous or non-aqueous solutions, suspensions or emulsions; or rectally as suppositories. The compositions may contain additional active ingredients. The analgesic activity of a narcotic analgesic agent is enhanced by administering, either simultaneously or from one hour before to one hour after the administration of the analgesic, the above potentiating agent.
[GB1250582A]
Patent IE-861083-L (IE)
Title: Antipsychotic benzisothiazole s-oxide
IPC: A61P25/24
Filed: 1986-04-23
Abstract: 8-[4-[4-(1-Oxo-1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspir o[4.5]decane-7,9-dione is an antipsychotic agent having reduced side effect liability.
[US4656173A]
Patent IE-43004-L (IE)
Title: Anilides.
IPC: A61K31/357
Filed: 1976-06-04
Abstract: A 2-hydroxyethylidene-cyano acetic acid anilide is prepared by heating an acetoacetic acid anilide with an orthoformic acid ester and acetic anhydride, isolating the resulting 2-alkoxymethylene-acetoacetic acid anilide and treating it with hydroxylamine and the isoxazole so obtained with a base, and optionally reacting the resulting alkali metal or ammonium salt with a mineral acid or a strong organic acid. The compounds of the invention have anti-inflammatory and analgesic activity.
[US4061767A]
Patent IE-841312-L (IE)
Title: Aspartame synthesis
IPC: A23L27/30
Filed: 1984-05-25
Abstract: A process for the preparation of the N-L- alpha -aspartyl-L-phenylalanine 1-methyl ester (aspartame) which is characterized by adding phosphoric acid and a lower alkyl alcohol to the reaction mixture containing N-formyl alpha -L-aspartyl- and beta -L-aspartyl-L-phenyl-alanine methyl ester and only one of the resultant deformylated isomers, i.e. aspartame phosphate precipitates. The alpha -isomer phosphate is collected by filtration and converted to free aspartame by treatment with a base.
[US4656304A]
Patent IE-821313-L (IE)
Title: PREPARATION OF ß-CYCLO-SUBSTITUTED ETHYLAMINES
IPC: C07D213/18
Filed: 1982-06-01
Abstract: The present invention provides a multistep process for the preparation of beta -cyclo-substituted ethylamines of the general formula:- Ar-CH2-CH2-NH2 +TM, (I) in which AR is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly- substituted, wherein said compounds represent a class of intermediates which can be converted to 4,5,6,7-tetrahydro[3,2-C] or [2,3-C]pyridines wherein the latter are useful for anti-inflammatory, vasodilator or blood platelet aggregation inhibition activities.
[US4493931A]
Patent IE-811344-L (IE)
Title: Indole and indoline derivatives
IPC: C07D209/08
Filed: 1981-06-17
Abstract: Indole and indoline derivatives of the formula:  <IMAGE>  wherein indicates a double bond or a single bond between carbon atoms, R1 represents hydrogen, alkyl of 1 through 6 carbon atoms, or alkyl of 1 through 6 carbon atoms substituted by one or more than one of the same type of substituents selected from the hydroxy group, alkenyl groups of 2 through 5 carbon atoms, and alkanoyloxy groups of 2 through 7 carbon atoms, and one of the symbols R2 represents alkyl of 6 through 24 carbon atoms and the other symbol R2 represents alkyl of 1 through 24 carbon atoms or hydrogen, and R3 represents alkyl of 1 through 6 carbon atoms or hydrogen, are new compounds possessing useful pharmacological properties. They are of use in the treatment of diabetes mellitus, hyperlipoproteinaemic states, of atherosclerosis, and of associated conditions.
Patent IE-39803-L (IE)
Title: Improved process for 11a-chlorination of oxytetracycline
IPC: C07C231/00
Filed: 1974-06-26
Abstract: 1465542 11a-Chloro-5-oxytetracycline-6,12- hemiketal PFIZER Inc 4 Feb 1974 [2 Aug 1973] 05124/74 Heading C2C 11a - Chloro - 5 - oxytetracycline - 6,12 - hemiketal is obtained in the form of a strong mineral acid addition salt by chlorinating 5-oxytetracycline or an acid addition salt thereof at - 10 to - 40 C. and pH 6À5-7À7 in a water-miscible reaction-inert solvent or its mixture with water and then adding a strong mineral acid to lower the pH of the reaction mixture thus obtained to <1À0. Reference has been directed by the Comptroller to Specification 998,294.
[GB1465542A]
Patent IE-45320-L (IE)
Title: 2-benzylpyrrolidines
IPC: C07D207/22
Filed: 1977-07-27
Abstract: 2-Benzylpyrrolidines bearing from 1 to 4 nuclear substituents on the benzyl ring are pharmacologically active, particularly on the CNS, on blood pressure and on pain sensation for warm-blooded animals. They are synthesized, e.g., by reducing appropriate 2-benzylpyrrolidines and are formulated into medicament compositions according to established conventional techniques.
[US4279918A]
Patent IE-41525-L (IE)
Title: Substituted phenylglycines
IPC: C07D501/36
Filed: 1974-07-24
Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
[US3953439A]
Patent IE-811580-L (IE)
Title: Herbicidal compounds
IPC: C07D211/90
Filed: 1981-07-14
Abstract: Aniline derivatives of the general formula: <IMAGE> (I) wherein X represents a halogen atom or a lower alkyl, lower alkoxy, lower alkenyl, lower alkenyloxy, lower alkyl substituted by one or more halogen atoms, nitro or cyano group or an amino group unsubstituted or substituted by one or two lower alkyl groups, which may be the same or different, or by a group -CO-R1 (wherein R1 represents a lower alkyl, lower alkoxy, mono (lower) alkylamino group or di (lower) alkylamino group wherein the lower alkyl groups may be the same or different), n represents 0 or an integer from 1 to 5 inclusive, it being understood that when n represents an integer from 2 to 5 inclusive, atoms or groups represented by X may be the same or different, and Q represents a group of the general formula: <IMAGE> wherein R2 and R3 may be the same or different and each represents a hydrogen atom or a lower alkyl group, and R4 represents a cyano group or a group -COR5, wherein R5 represents a hydroxy or OR6 group, wherein R6 represents a lower alkyl group and, when R5 represents a hydroxy group, agriculturally-acceptable inorganic and organic salt thereof, and, when Q represents a group of general formula IIB, wherein R2, R3 and R4 are as hereinbefore defined, agriculturally acceptable acid addition salts thereof possess useful herbicidal properties.
[US4493729A]
Patent IE-851691-L (IE)
Title: Tumor necrosis factor
IPC: C07K14/525
Filed: 1985-07-04
Abstract: Methods and compositions are provided for the purification of a protein identified as tumor necrosis factor from nonrecombinant and recombinant sources, the preparation of nucleic acid encoding this tumor necrosis factor and for its expression in recombinant hosts. This tumor necrosis factor is used in the therapeutic treatment of malignant tumors, either alone or in synergistic combination with an interferon.
Patent IE-791886-L (IE)
Title: Flavouring frozen foods
IPC: A23L33/115
Filed: 1979-10-04
Abstract: A method of applying flavorings and edible fats on to deep-frozen foods with free apportionability so as to obtain a food product ready for consumption merely by adding water and applying heat, characterized in that the intended flavoring and aromatic substances are prepared in a separate mixture and swelling substances are incorporated into this mixture, which swelling substances are capable of binding, as a result of their swelling characteristics, the free water occurring during the mixing with the deep-frozen products and also in the end product, to such an extent that a free-flowing mixture is obtained.
[US4328253A]
Patent IE-771967-L (IE)
Title: Pharmaceutical compostions
IPC: A61P9/10
Filed: 1977-09-27
Abstract: L- and DL- Phenylglycines of the formula <IMAGE> (I) and pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl and R1 is NH2, OH or completes a carboxylic ester group, useful in treating certain cardiovascular diseases, diabetes and obesity.
[US4148920A]
Patent IE-41947-L (IE)
Title: Digital device for detecting the presence of an nrz message
IPC: H04L25/49
Filed: 1975-11-24
Abstract: The device comes within the branch of digital transmission and refers more particularly to the problem of the recognition of a message coded in the "no return to zero" code, which is usually rhythmed by a given frequency. According to the invention, a phase-locked loop is provided for reconstituting the original rhythm from the message, and a phase shifter having an instantaneous action is additionally provided in that loop. The analysis of the reaction of the loop after that phase shift, by means of integrators, gives a statistical data information on the existence of a message. The invention applies more particularly to very noisy NRZ transmission lines.
[US4029905A]
Patent IE-43891-L (IE)
Title: Electrolytic resistor
IPC: H01C11/00
Filed: 1976-12-02
Abstract: The invention relates to an electrolytic resistor comprising a water-repellent insulating tube through which there flows an alkaline solution containing a suspension of zinc. The positive end of the resistor has a metallic grid suitable for trapping the zinc particles, and the negative end has either an air electrode or a ring made of a metal having, more especially, high hydrogen supertension, this ring itself possibly having holes or projections suitable for promoting the progressive deposition of zinc dendrites. The invention is used in zinc-air storage cells.
[US4112409A]
Patent IE-873184-L (IE)
Title: CYCLOALKA £b| PYRAZOLO £3,4-d| PYRIDIN-3-ONES
IPC: C07D471/10
Filed: 1987-11-24
Abstract: Compounds of the formula IA or IB <CHEM> wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 8, 9, 10, 11 or 12 membered carbocyclic ring selected from cycloocteno, cyclononeno, cyclodeceno, cycloundeceno and cyclododeceno; each unsubstituted or mono-, di-, tri- or tetra-substituted on carbon atoms within A by lower alkyl, lower alkylidene, C3-C7-cycloalkyl, hydroxy, acyloxy, oxo, lower alkoxy, aryl or aryl-lower alkoxy; and when disubstituted on the same carbon atom within A, said carbon atom in each ring is substituted by two lower alkyl or two aryl-lower alkyl groups, or by one lower alkyl or aryl-lower alkyl group and one group selected from hydroxy, lower alkoxy, aryl-lower alkoxy and acyloxy groups; or each disubstituted on the same carbon atom within A by straight chain alkylene of 2 to 6 carbon atoms forming the carbon to which the alkylene chain is attached a spiro-fused 3 to 7 membered ring; or each ring ring; R1 represents lower alkyl, phenyl, or phenyl substituted by one or two radicals selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl; or R1 represents a five-membered unsaturated heterocyclic radical containing one hetero atom selected from sulfur, oxygen, and unsubstituted or lower alkyl substituted amino nitrogen, or a said radical containing two hetero atoms consisting of one imino nitrogen and one member selected from unsubstituted or lower alkyl substituted amino nitrogen, sulfur and oxygen; or R1 represents an unsaturated six membered heterocyclic radical containing one or two nitrogen atoms; or R1 represents a bicyclic benzo-fused five membered unsaturated heterocyclic radical containing one hetero atom selected from sulfur, oxygen and unsubstituted or lower alkyl substituted amino nitrogen; or R1 represents a bicyclic benzo-fused five membered unsaturated heterocyclic radical containing two hetero atoms consisting of one imino nitrogen and one member selected from unsubstituted or lower alkyl substituted amino nitrogen, oxygen and sulfur; or R1 represents a bicyclic benzo-fused 6-membered unsaturated heterocyclic radical containing one or two nitrogen atoms; or R1 represents any of said heterocyclic radicals mono- or di-substituted on carbon by lower alkoxy, lower alkyl or halogen; R2, R3 and R3' independently represent hydrogen or lower alkyl; or tautomers thereof; or a pharmaceutically acceptable salt thereof; are useful as benzodizepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed. They can be prepared for example by reacting a pyridin-4-one-3-carboxylate compound (III) with a compound of formula R @-NH-NH-R1(IV).
Patent IE-853303-L (IE)
Title: Fluoridated telomers
IPC: A62D1/00
Filed: 1985-12-23
Abstract: Fluorinated telomers which can be defined by the formula: RF-CmH2m-(CH2-CR1R2)nX (I) wherein RF is a poly- or perfluorinated radical; X is iodine, chlorine or bromine; m is 0, 1 or 2; n is from 5 to 1000; R1 is hydrogen or methyl; and R2 is a -COOH or -CONR3R4 group, R3 and R4 being hydrogen or alkyl or hydroxyalkyl radicals, such telomers being obtained by free radical reaction of an ethylenic monomer CH2=CR1R2 with a fluorinated telogen RF-CmH2m-X, and being excellent surfactants in aqueous media with special usefulness as additives to fire-fighting protein-based emulsifiers.
Patent NO-812301-L (NO)
Title: Fremgangsmaate for varmebehandling av metall
Inventor: CRAVENS CHARLES FADJO
IPC: C21D9/50
Filed: 1981-07-06
Abstract: Fremgangsmåte for avlastning av spenning i mikro-struktursveisesømmer og den varmepåvirkede sonen. i tilliggende basismetall ved lavlegeringsstål ved hjelp av induksjonsoppvarming ved den andre etter-sveisevarmebehandling. Det oppvarmede området blir overvåket med et strålingspyrometer for å sikre nøyaktig temperaturstyring av prosedyren.
Patent NO-814312-L (NO)
Inventor: BRYANT ROBERT JOHN
IPC: C07C43/23
Filed: 1981-12-16
Abstract: The present invention provides a process for the preparation of compounds of the general formula 
<CHEM>
 wherein A represents the residue of an aromatic ring forming the whole or a part of a monocyclic or polycyclic, at least partially-aromatic, carbocyclic and/or heterocyclic ring system, optionally bearing one or more other substituents inert to the reactants here employed, and R represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms. According to the process of the invention such compounds are prepared by causing an aromatic compound of the general formula: 
<CHEM>
 wherein A is as defined above and X represents a chlorine, bromine or iodine atom, to react with an alcoholate of the general formula: 
<CHEM>
 in which M represents an alkali metal or an alkaline earth metal atom; n is the valency of M; and R is as defined above, in the presence of a catalytically-effective amount of an active catalyst mixture comprising:
 (i) a formic acid ester of an aliphatic organic alcohol having the general formula:
 R<2>-O-CO-H (V)
 in which R<2> represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms; and
 (ii) a cuprous salt;
 in a liquid medium which is a solvent for the catalyst mixture and in which the compound of formula II is at least partially soluble, under substantially anhydrous conditions and a nonoxidising atmosphere, to yield the desired corresponding compound of formula VI.
Patent NO-821361-L (NO)
Title: Nye 1-(3-(6-fluor-1,2-benzisoksazol-3-yl)propyl)-4-hydroksy-4-fenylpiperidiner, fremgangsmaate og mellomprodukter for deres fremstilling og deres bruk som legemidler
Inventor: DAVIS LARRY
IPC: C07C49/825
Filed: 1982-04-26
Abstract: 1-[3-(6-fluor-1,2-benzisoksazol-3-yl)propyl]-4-hydroksy-4-fenylpiperidiner med formelen. hvori X betyr-hydrogen, laverealkyl, laverealkoksy, halogen eller trifluormetyl, Y betyr hydrogen eller trifluormetyl med det forbehold at Y er hydrogen når X er hydrogen, laverealkyl, laverealkoksy eller trifluormetyl og Y er hydrogen, trifluormetyl når X er hydrogen samt de optiske antipoder herav eller farmasøytisk godtagbart syreaddisjonssalt herav. Det omtaltes også fremgangsmåte for fremstilling av piperi-dinene samt en fremgangsmåte for fremstilling av mellomprodukter samt anvendelse av piperi-dinene som medikamenter.
Patent NO-822422-L (NO)
Inventor: HETZELT STEPHAN
IPC: A63C9/20
Filed: 1982-07-13
Abstract: The invention concerns a ski particularly a touring and/or cross-country ski, with a binding (10) for holding an anterior tongue-shaped extension of the sole of a ski shoe. The binding (10) is formed by a recess (16) provided in the ski body (12) extending in the longitudinal direction of the ski, with a sole latching apparatus (abutments 18, 18'; latching device 20 or locking device 20') for fixing the sole extension and thus the ski shoe in a positively locked and friction-locked manner. The ski binding (10) is thus provided in the ski body (12) in integrated manner, so that no parts protrude above the ski deck area (14). In this way a subsequent mounting of the ski binding (10) is no longer necessary. In addition, the skis can be shipped with the ski binding (10) mounted for conventional skis without binding, tightly packed against each other. Finally, there is no additional friction caused by the ski binding during the cross-country run in somewhat deeper snow.
Patent NO-831560-L (NO)
Inventor: MAEKELAE PAAVO
IPC: E03F5/04
Filed: 1983-05-03
Abstract: A floor drain or some other cup-shaped water seal, comprising a cupped body (1), a superstructure including a trash screen (2), a water seal forming wall (3), and an outlet (4) for a sewer pipe (5). A problem is to improve the superstructure of a floor drain so as to prevent bacteria from spreading out along moist surface films or membranes. In order to resolve the problem, the superstructure is provided with a funnel-shaped ring (6), which is fitted below trash screen (2) and whose central hole (7) is smaller than said outlet (4) and whose outer rim is tightly (8) sealed to body (1).
Patent NO-853507-L (NO)
Inventor: HELD PETER
IPC: A01G3/025
Filed: 1985-09-06
Abstract: In pruning shears a rope-and-pulley device is incorporated between the shears legs in such a manner that by pulling the free end of the rope an amplified closing force is obtained. For convenient remote operation one shears leg force lever arm is connected fixedly or detachably to a handle of any desired length, by a handle securing coupling which extends parallel to the shears leg. An opening spring biases the shears in the opening direction.
Patent NO-854049-L (NO)
Inventor: HELLGREN LARS
IPC: A61K35/48
Filed: 1985-10-11
Abstract: An erection and fertility promoting agent which contains as its active component such lipid fractions derived from Cowper's and/or Bartholin's glands as those which contract gerbil colon. The invention also relates to a method for producing the agent and to the use of the agent for preparing erection and fertility promoting compositions.
Patent NO-883708-L (NO)
Inventor: KITSIOS EFSTATHIOS EUGENE
IPC: G01V1/40
Filed: 1988-08-19
Abstract: A method and apparatus are disclosed for producing pressure variations in a drilling fluid flowing through a pipe string within a borehole. The method comprises establishing fluidic oscillation in a stream of drilling fluid and amplifying the oscillating flow of drilling fluid to establish a series of high pressure gradients in the drilling fluid stream. The apparatus comprises a fluidic oscillator means (1) and a fluidic amplifier (7) downstream from the fluidic oscillator means. The amplifier is preferably a vortex amplifier having the radial inlet port (7B) connected to one outlet conduit of a fluidic oscillator of the Coanda type and having the tangential inlet port (7A) connected to the other outlet of the fluidic oscillator.
Patent NO-892077-L (NO)
Inventor: STEPHAN GUENTER
IPC: A61K9/48
Filed: 1989-05-24
Abstract: In order to improve the bioavailability of a soft gelatin capsule containing a plant extract, which is extracted with water and/or alcohol, in a low-cost, straightforward manner and to achieve optimisation between the substance and its vehicle, the liquid vehicle used for the plant extract is a solvent for the latter from the group of polycondensed alcohols, polyols or the monomethyl or monoethyl esters thereof, it being possible and advantageous to add biological complex-forming solubilisers of the phosphatide group to the solvent vehicle.
Patent NO-893245-L (NO)
Inventor: NIEDBALLA ULRICH
IPC: A61P43/00
Filed: 1989-08-11
Abstract: Porphyrin complex compounds consisting of at least one porphyrin ligand, optionally at least one ion of an element of atomic numbers 5, 13, 21-32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic media and therapeutic agents.
Patent NO-894460-L (NO)
Inventor: LIPTAK GABOR
IPC: H02K3/34
Filed: 1989-11-08
Abstract: In an insulating system for high-voltage machines, a three-layer insulating tape is proposed as turn-to-turn insulation which comprises a center mica layer (1) which is covered on both sides by plastic foils (2,3) having different thickness. Thermoplastic adhesive layers (4,5) on the outer surfaces of the foils (2,3) produce an intimate bonding of the turn-to-turn insulation to the conductor elements and to the main insulation. An insulation of such construction is distinguished by a high electrical life at increased temperature and a high surge withstand capability.