baber/WOPTO huggingface dataset:
Patent EP-0592433-B1 (EP)
Title: Sertindole prodrugs
Inventor: PERREGAARD JENS KRISTIAN
IPC: A61K31/4427
Filed: 1991-09-27
Granted: 1999-01-20
Abstract: Reaction products of sertindole with an acid or an activated acid, with formaldehyde alone, formaldehyde in the presence of an alcohol or an amine, or with an acyloxymethylene halide, and having general formula (1) wherein X is CO, CS, or CH2, and if X is CO or CS, R is (i) hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl or cycloalk(en)ylalk(en)yl optionally substituted with hydroxy, or optionally substituted phenyl; or (ii) YR1, wherein Y is O or S and R1 is one of the substituents defined for R under (i) above; or (iii) NR2R3, wherein R2 and R3 independently are selected from the substituents defined for R under (i) above or R2 and R3 are combined to form a heterocyclic ring; or if X is CH2, R is: (iv) a group YR1 as defined in (ii); (v) a group NR2R3 as defined in (iii); or (vi) a group OC(O)R4, wherein R4 is as defined for R1; are prodrugs of sertindole and show sustained release of sertindole when injected as formulated in a suitable oil. The compounds are useful in the treatment of mental disorders such as schizophrenia including both negative and positive symptoms, non-schizophrenic psychoses, depression and anxiety.
Patent EP-0509382-B1 (EP)
Inventor: WOODBURY RICHARD PAUL
IPC: C07C323/52
Filed: 1992-04-08
Granted: 1998-11-04
Abstract: A process of stabilizing bleaching agents in a detergent composition using a nonphosphorus-containing biodegradable stabilizer. The process involves incorporating into a detergent composition containing a bleaching agent, a biodegradable compound of the formula   <CHEM> in which m is NR' or sulfur; X is SO3H or COOH; Y is hydrogen, SO3H or COOH; R and R' are, independently, hydrogen, -CH(Z)CH2(Z'), -CH(Z)CH(Z')(Z'') or -CH2COOH; and Z, Z' and Z'' are, independently, hydrogen, OH, SO3H or COOH; or a sodium, potassium or ammonium salt thereof, in an amount sufficient to stabilize the bleaching agent. Novel detergent compositions containing the biodegradable bleach stabilizers are also disclosed.
Patent EP-0555515-B1 (EP)
Inventor: HILL ALAN M
IPC: B31B50/25
Filed: 1992-05-21
Granted: 1997-04-23
Abstract: Box blank-forming apparatus (60) is provided which includes a feeder assembly (62) and a scoring/slotting assembly (64) each provided with adjustment structure (62a, 64a) to facilitate makeready adjustment of the apparatus (60) between production runs. The feeder assembly (62) preferably includes a reciprocal pusher element (170) operable to successively engage sheets (30) to be formed into box blanks (36). The element (170) is supported by a pair of elongated, threaded, axially rotatable, fore and aft translatable positioning screws (146, 148), so that upon rotation of the screws (146, 148), a reference position of the pusher element (170) may be varied. Adjustment of the assembly (64) is accomplished by means of compensators (292, 294) which are respectively coupled to associated slotter wheel and scoring wheel shafts (288, 286). Operation of the slotter wheel shaft compensator (294) serves to adjust the circumferential positions of the fixed slotter knives (358), whereas operation of the scoring shaft compensator (292) varies the position of the adjustable knives (360) through the medium of transfer gears (384). Servo-sensors (438-442, 446-448 and 270) are used to continuously monitor the lateral and circumferential positions of the scoring/slotting stations (296-304) and a reference position of the pusher element (172), so that precise makeready adjustments can be accomplished. <IMAGE>
Patent EP-0577866-B1 (EP)
Inventor: CAMPS AN JOSEPHA MARIA
IPC: B65D5/74
Filed: 1992-07-06
Granted: 1996-01-24
Abstract: The present invention relates to a reclosable opening member (10) for pouring liquids from packaging containers. In particular, the opening member comprises a push-in opening in the form of a flap door (28). The flap door (28) is hinged (29) to the opening member (10) providing a puring aperture when pushed-in. The flap door (28) is pushed-in by a lever (20) which is cantilevered on one side of the pouring aperture of the reclosable opening member (10). The push-in lever (20) has a recess along its side into which the flap door (28) engages upon initial opening. In another aspect of the present invention the reclosable opening member (10) is joined to a laminate container such that the pouring aperture corresponds to a designated opening aperture in a container. Thereby a permanently open opening aperture in the container is provided when activating the opening member. <IMAGE>   <IMAGE>
Patent EP-0534496-B1 (EP)
Inventor: KEELER NORRIS R
IPC: G01S17/86
Filed: 1992-10-31
Granted: 1996-06-26
Abstract: An underwater manoeuvrable vehicle 10 is presented which carries an explosive charge and can be used for immediate removal or destruction of various menaces to navigation and other underwater hazards. The battery powered vehicle 10 is preferably air dropped from an airborne platform 12 which carries an imaging lidar system 36 to obtain an image of the vehicle 10 and the selected navigational hazard (58). An optical lidar downlink is used to control the submerged underwater manoeuvrable vehicle 10 from the airbrone platform 12. The downlink is pulse space modulated. Command signals 132 are decoded aboard the vehicle 10. Control in speed, heading and depth, as well as command detonation are available using this technique. <IMAGE>
Patent EP-0506515-B1 (EP)
Inventor: BOUILLOUX ALAIN
IPC: C08L23/02
Filed: 1992-03-17
Granted: 1996-08-14
Abstract: Polymer film made from a polyamide/polyolefin alloy for the manufacture of a sheet compounding product, characterised in that it comprises the components A, B, C and D according to the following percentages by weight:  30 </= A + B + C </= 60      0 </= A </= 60  and  B + C >/= 1      where 0 </= B </= 60  and  A + B + C + D = 100      where 0 </= C </= 60; the said components A, B, C and D having the following compositions:     A consists of at least one polyolefin composed of a partially or completely linear alpha-olefin; B represents the alpha-olefin described in A on which one or two functionalised monomers have been grafted; C is a grafted copolymer consisting of at least one monoaminated polyamide oligomer and of an alpha-monoolefin polymer or copolymer grafted by a monomer capable of reacting with the amine function of the said monoaminated oligomer;   D consists of at least one aliphatic (co)polyamide. t
Patent EP-0547924-B1 (EP)
Inventor: BONNEAU LIONNEL
IPC: C01F17/00
Filed: 1992-10-16
Granted: 1997-02-05
Abstract: The invention relates to compositions based on ceric oxide, whose specific surface has been stabilised by addition of silicon. These compositions have, after calcination at 800 DEG C for 6 hours, a specific surface of at least 40 m<2>/g and, after calcination at 1000 DEG C for 6 hours, a specific surface of at least 20 m<2>/g. Their silicon content is preferably less than 1 % by weight. They have a remarkably low crystallite size, even at high temperatures. They are obtained according to one of the processes consisting in autoclaving a cerium hydroxynitrate suspension in basic medium and in the presence of a silicon compound, in recovering the product obtained and in then calcining it. The compositions can be used as catalysts and/or as catalyst supports.
Patent EP-0597888-B1 (EP)
Inventor: COOK JOHN E
IPC: F02M25/08
Filed: 1992-07-15
Granted: 1996-01-10
Abstract: Electrovanne (CPS) de purge de cartouche filtrante à pentes multiples (10) possédant une vanne régulée par diaphragmes situés en aval d'une vanne actionnée par électroaimants (22). La vanne régulée par diaphragmes comporte deux diaphragmes (36, 44) définissant entre eux un espace formant une chambre (42) communiquant avec le vide de la tubulure d'admission. L'un (44) des deux diaphragmes est exposé à la pression atmosphérique, tandis que l'autre (36) est exposé à l'intérieur de l'électrovanne (CPS).
Patent EP-0604443-B1 (EP)
Inventor: TOKARZ MAREK
IPC: C04B41/68
Filed: 1992-06-12
Granted: 1997-11-19
Abstract: The invention concerns a method of protecting a surface of a carbonatic material from corrosion, the method comprising treatment of the material surface with an acidic cationic silica sol, the pH of the sol preferably being from about 4 to about 7. The invention also concerns a new silica sol useful for performing the method and a method of preparing the new silica sol. Further, the invention concerns carbonatic material comprising a surface layer of silica, the surface of the silica particles comprising a polyvalent metal oxide/hydroxide.
Patent EP-0597922-B1 (EP)
Inventor: OO KAH SENG
IPC: B60K31/00
Filed: 1992-07-29
Granted: 1996-01-31
Abstract: A speed control system electronically controls the engine throttle to maintain vehicle speed at a reference speed in response to a control signal. The control signal is generated by multiplying a speed error signal by a gain value. Such gain value is provided with a variable amplitude having a first linear relationship to the error signal which is increased to a second linear relationship having greater sensitivity when the error signal exceeds a preselected amplitude.
Patent EP-0612259-B1 (EP)
Inventor: SCHOENDORF ERHARD
IPC: A61N1/32
Filed: 1992-09-14
Granted: 1996-11-20
Abstract: PCT No. PCT/DE92/00801 Sec. 371 Date Jun. 20, 1994 Sec. 102(e) Date Jun. 20, 1994 PCT Filed Sep. 14, 1992 PCT Pub. No. WO93/09843 PCT Pub. Date May 27, 1993.An electrotherapeutic field stimulator includes at least a pair of electrodes for applying the electricity to the body in the form of an electric field and a generator for providing the electricity to the electrodes in the form of at least two superimposed alternating current fields of different frequencies to provide the treatment waveform.
Patent EP-0553663-B1 (EP)
Inventor: HOEHLEIN PETER DR
IPC: C08G18/42
Filed: 1993-01-15
Granted: 1995-05-03
Abstract: A process for the preparation of thixotropic paint binders based on alkyd resins, essentially comprising a) from 80 to 98 % by weight of alkyd resins having oil contents of from 20 to 86 % by weight and b) from 2 to 20 % by weight of a thixotropy carrier comprising b1) polyisocyanates having pendant alkyl substituents and having a molecular weight of up to 1 000, and b2) monohydric and/or dihydric alcohols having a molecular weight in the range from 32 to 800, in which the thixotropy carrier is prepared by reacting starting components b1) and b2) while maintaining an NCO/OH equivalent ratio of from 2:1 to 1:2 at from 50 to 180 DEG C in the presence of at least some of the alkyd resin a), and optionally in the presence of inert solvents, and the use of the binders which have been rendered thixotropic, obtained by this process, optionally in combination with crosslinker resins as binder or a binder component for coating compositions.
Patent EP-0579210-B1 (EP)
Inventor: STEGEMANN ROBERT DIPL-ING
IPC: C10G9/14
Filed: 1993-07-14
Granted: 1996-03-27
Abstract: Modification of hydrocarbon cracking furnaces, which have radiant and convection zones and which are secured by frames, involves combining at least two existing furnaces to form a single structure by: (a) disassembling the convection zones of the furnaces and extending the radiant zones to the height of the existing frames; (b) extending the frames into or above the interspace between the original furnaces by means of an additional connecting frame; and (c) incorporating the convection zones of the furnaces in this additional frame.
Patent EP-0582973-B1 (EP)
Inventor: KATO KAZUHIKO
IPC: B41F33/00
Filed: 1993-08-05
Granted: 1997-01-02
Abstract: A preset state display apparatus includes a position detector (8), a memory (2), and a display (4). The position detector detects a set state of an adjustment portion adjusted in a change in printed matter or the like in a printing press. The memory stores a current set state of the adjustment portion which is detected by the position detector in correspondence with a key number represented by a storage command generated upon designation of the key number. The display calls, as a preset state, the set state of the adjustment portion which is stored in correspondence with the designated key number, in accordance with a call command generated upon designation of the key number, to display the preset state near an operation member (6-1 - 6-4) corresponding to the adjustment portion. <IMAGE>
Patent EP-0568323-B1 (EP)
Inventor: CLAUSS STEPHEN L
IPC: A61K31/00
Filed: 1993-04-27
Granted: 1997-04-02
Abstract: A storage stable porfimer sodium (polyhematoporphyrin ether/ester) composition useful in the photodynamic therapy of cancer and other conditions is provided. The composition is characterized in that the percentage of ester linked porphyrin oligomers is less than 10% of the composition. Improved processes for preparing such compositions are also provided wherein acetylated hematoporphyrin is treated with alkali for sufficient time and temperature to reduce the amount of porphyrin oligomers joined by ester linkages to less than 10% of the composition.
Patent EP-0606778-B1 (EP)
Inventor: WALLACE RONALD
IPC: A24C5/18
Filed: 1993-12-30
Granted: 1999-08-04
Abstract: A method for making cigarettes includes heating the cut filler, which has a moisture content of greater than 12.4% by weight to a temperature greater than 35 DEG C prior to making the cigarettes therefrom. Apparatus for use in the method is a modified conventional maker, in which winnowing of the filler is achieved by entraining the particles of filler in hot air. The hot air is provided by a fan 44 which blows air through a heat exchanger 52 and along ducting 54 to the jet block 34 of the maker. Hot air is also supplied to the flotation chamber of the maker from heating coil 66 through ducting 68. <IMAGE>
Patent EP-0656002-B1 (EP)
Inventor: MARYANOFF BRUCE E
IPC: C07D471/04
Filed: 1993-08-18
Granted: 2000-11-08
Abstract: PCT No. PCT/US93/07794 Sec. 371 Date Feb. 16, 1995 Sec. 102(e) Date Feb. 16, 1995 PCT Filed Aug. 18, 1993 PCT Pub. No. WO94/04532 PCT Pub. Date Mar. 3, 1994The present invention is directed to compounds of the following formula I:    <IMAGE>  I  wherein R, R1, R2, R3, R4, A, n, X, and Y are as defined hereinafter. The compounds of formula I are useful in treating central nervous system disorders. The compounds are ligands for the BZD binding site on GABA-A receptors, and are thus useful as muscle relaxants, hypnotics/sedatives including sleep-aids, anxiolytics, anticonvulsants/antiepileptics, anti-inebriants, and antidotes for drug overdose (particularly benzodiazepine overdose).
Patent EP-0679546-B1 (EP)
Inventor: KREYE BERNHARD
IPC: B60J10/70
Filed: 1994-04-20
Granted: 1996-12-18
Abstract: A window structure for a vehicle, with an outer injected frame structure of PVC etc. projecting from the bodywork, has a channel (6) round it on the side towards the window pane and open to the bodywork metal. After the frame has been injected, the channel is filled with a polyurethane mass, to bond to the pane with an adhesive (11). The polyurethane mass (7) and the bodywork metal (5) are bonded together by an adhesive or inserted strip (9) of polyurethane which is tensed on assembly and pressed together. Also claimed is an appts. for the prodn. of the window assembly with two distance pieces placed against the pane, to be removed after the polyurethane mass (7) has hardened. <IMAGE>
Patent EP-0654484-B1 (EP)
Inventor: HETTCHE HELMUT
IPC: A61K47/48
Filed: 1994-10-18
Granted: 2003-04-23
Abstract: Medicament (A) contains thioctic acid or dihydroliponic acid (II) in the form of an inclusion cpd. with a cyclodextrin or deriv.. Medicament (B) contg. (I) or salt and formulated as a granulate, chewable or effervescent tablet or suppository is also claimed. (I) and (II) can be present as the racemate or as the (R)- or (S)-enantiomer. Inclusion cpds. formed with the (R)- and (S)-enantiomers of (I) and (II) are claimed. Pref. medicament (B) as a granulate or tablet contains, in addition to (I) and opt. conventional flavourings, sweeteners and aromas, 0.001-1 pt.wt. binder and 0.001-0.1 pt.wt. flow aid and, in the case of effervescent tablets, 0.05-30 pts.wt. effervescent mixt.; pts.wt. being based on (I). In these granulates and tablets as well as in suppositories (I) can be embedded in a fat, polymer and/or swelling agent. Further, granules may be provided with a coating. beta -cyclodextrin is esp. suitable. When a cyclodextrin deriv. is used, this may conveniently be a methyl, ethyl, carboxymethyl, hydroxyalkyl, dialkylaminoethyl, sulphoalkyl, partially methylated carboxyalkyl, dimerised or branched-chain cyclodextrin.
Patent EP-0639345-B1 (EP)
Inventor: BAKER STEPHEN
IPC: A47K4/00
Filed: 1994-08-15
Granted: 1997-04-02
Abstract: The invention relates to a moulded shower enclosure formed in three parts one above the other, and including a base part (13), a central U-shaped part (14) and a top part (15). The enclosure has a base (25), defining a waste outlet (30), and a back (18) and two side walls (16, 17) and has no vertical joints or seams. Support feet (26) project downwardly from the base for supporting the enclosure on the ground so that waste pipes (31) can be located between the base and the ground (27). The parts (13, 14, 15) are formed at their mating surfaces by connectable and disconnectable fixing means (47, 48), so that the enclosure has its own structural stability. <IMAGE>
Patent EP-0654250-B1 (EP)
Title: Form-fitting mesh implant
Inventor: REISBERG ERHARD
IPC: A61F2/28
Filed: 1994-10-13
Granted: 1999-12-22
Abstract: A mesh grid implant of titanium or other biocompatible material having a plurality of orifice plate sections (40,42) that accept bone screws and having connecting arms (44) coupling each orifice plate section (40,42) with each adjacent orifice plate section (40,42). The length of the arm (44) and the included angle (46) may be set to determine the flexibility of the mesh grid. The arms (44) allow the mesh to cover not only flat bone segments but also to conform to curved, concave, and convex bone surfaces. <IMAGE>
Patent EP-0645240-B1 (EP)
Inventor: SAUER GERD M
IPC: B32B17/10
Filed: 1994-09-21
Granted: 1998-07-01
Abstract: A motor-vehicle window (1) made of laminated glass is provided with several antenna wires (2, 3, 4) having a diameter of 15 to 50  mu m, these being arranged parallel to each other and being almost invisible to the naked eye. In order to manufacture such an antenna window, the antenna wires (2, 3, 4) are arranged and fixed to an intermediate support skin provided with an adhesive layer consisting of the same thermoplastic polymer as the interlayer (intermediate layer) of the laminated-glass window (1). By means of the intermediate support skin, the wires (2, 3, 4) are transferred onto one of the two individual glass sheets forming the laminated-glass window. After removing the intermediate support skin, the two individual glass sheets and the thermoplastic skin forming the interlayer are converted, in the usual way, into a laminated-glass window (1). <IMAGE>
Patent EP-0689708-B1 (EP)
Title: Appareil compatible d'enregistrement et/ou de lecture
Inventor: ZUCKER FRIEDHELM
IPC: G11B7/00
Filed: 1994-03-08
Granted: 1997-09-17
Abstract: Un procédé et un agencement pour un appareil compatible d'enregistrement et/ou de lecture permettant de lire et/ou d'enregistrer des informations sur des supports optiques d'informations (CD) ayant différentes densités d'enregistrement d'informations. L'objet de l'invention est d'obtenir un appareil d'enregistrement et/ou de lecture de supports optiques d'informations (CD) compatible avec différentes densités d'enregistrement, en dépit d'un rapport à respecter entre les dimensions des creux, des domaines et des taches lumineuses; cet appareil a un laser (LD) qui émet une lumière d'une longueur d'onde déterminée et un objectif (OL) ayant une distance focale prédéterminée. A cet effet, on utilise une source de lumière dont la longueur d'onde et les dimensions de la tache lumineuse sont adaptées à la densité d'enregistrement du support d'informations (CD) ayant la plus haute densité d'enregistrement. Un organe défocalisateur défocalise la lumière dirigée sur le support d'informations (CD) afin d'agrandir la tache lumineuse sur des supports d'informations (CD) ayant une densité inférieure d'enregistrement. L'invention a des applications dans des appareils d'enregistrement et/ou de lecture aussi bien des supports optiques usuels d'informations (CD) sous forme de disques compacts, minidisques ou MOD normalisés, que de supports optiques d'informations (CD) ayant une densité d'enregistrement d'informations relativement plus élevée, un écartement réduit entre les pistes, ou des creux ou des structures d'enregistement de dimensions réduites.
Patent EP-0690918-B1 (EP)
Inventor: MOLLER NIELS P H
IPC: C12N9/16
Filed: 1994-03-23
Granted: 2007-09-05
Abstract: A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.
Patent EP-0697136-B1 (EP)
Inventor: FRANCK GUENTER
IPC: H01J61/70
Filed: 1994-04-27
Granted: 1997-12-03
Abstract: PCT No. PCT/DE94/00464 Sec. 371 Date Oct. 23, 1995 Sec. 102(e) Date Oct. 23, 1995 PCT Filed Apr. 27, 1994 PCT Pub. No. WO94/25978 PCT Pub. Date Nov. 10, 1994The invention relates to a compact fluorescent light bulb in the form of a reflector lamp. The discharge vessel (3) of the light bulb according to the invention preferably comprises a plurality of U-shaped glass tubes (30, 31), which are located in the same plane at right angles to the reflector axis. As a result, on the one hand a short structural length is attained, which is only insignificantly greater than that of a commercially available general-purpose incandescent bulb, and on the other, the reflector lamp of the invention, when used in ceilings or chandeliers, has a horizontal lighting intensity that is increased by the factor of 4 over a conventional compact fluorescent light bulb.
Patent EP-0695305-B1 (EP)
Inventor: LETSINGER ROBERT L
IPC: C12Q1/6813
Filed: 1994-04-06
Granted: 2003-08-06
Abstract: A process for non-enzymatic convalent ligation of two oligonucleotides having the structure shown below:   <IMAGE>    <IMAGE>   The spontaneous reaction of these above oligonucleotides produces a thiophosphorylacetylamino linkage as shown below:   <IMAGE>   When carried out in the presence of a template, this reaction gives 90% yields within 20 minutes at micromolar concentrations.
Patent EP-0701685-B1 (EP)
Inventor: JONSSON RUNE
IPC: G07B15/06
Filed: 1994-05-27
Granted: 1999-04-21
Abstract: PCT No. PCT/SE94/00503 Sec. 371 Date Jul. 23, 1996 Sec. 102(e) Date Jul. 23, 1996 PCT Filed May 27, 1994 PCT Pub. No. WO94/28377 PCT Pub. Date Dec. 8, 1994A device and method for registering the displacement of a vehicle using a video camera device located above the ground and including a pair of cameras spaced parallel to the ground and directed to record on their respective image planes areas of the ground which overlap at least partly whereby there are produced in the cameras pairs of stereo records. These pairs of stereo records are utilized in an image processing of the mutual locations of contrast fields within the contour of the vehicle for comparison. The contrast fields are located at different height levels above the ground so that evaluation of at least one of the fields may be used in the image processing as an indicator in tracking the displacement of the vehicle for successive positions of displacement to be registered.