baber/WOPTO huggingface dataset:
Patent BR-PI1004172-B1 (BR)
Title: Metodologia de formulação e cura de compósitos particulados em resinas epóxi dgebaaminas alifáticas
Inventor: RUBEN JESUS SANCHES RODRIGUES
IPC: C08G59/06
Filed: 2010-10-08
Abstract: metodologia de formulação e cura de compósitos particulados em resina epóxi dgeba-aminas alifáticas a presente patente de invenção refere-se à metodologia de formulação de compósitos dgeba-amina e ao tratamento térmico de cura adequado para resinas epáxi do tipo dgeba utilizando aminas alifáticas corno agentes endurecedores e como matriz na formulação de compósitos particulados, incluindo sua particular aplicação como matriz para a formulação de compósitos abrasivos, visto o impacto nas propriedades mecânicas que a metodologia de preparação gera na matriz e nos compósitos, possuindo larga aplicação na arca de ferramentas diamantadas e extensível a outras áreas de aplicação como base de máquinas ferramentas, máquinas de medição por coordenadas, etc.
Patent BR-PI1005663-B1 (BR)
Title: sistema para rebocar um cabo flutuante de sensor geofísico marinho e método para rebocar um cabo flutuante de sensores em um corpo de água
Inventor: KENNETH KARLSEN
IPC: G01V1/38
Filed: 2010-12-29
Abstract: sistema para ajustar a profundidade de reboque da extremidade dianteira da fita de sensor geo-físico. a presente invenção refere-se a um sistema para rebocar fita de sensor geofisico marinho inclui uma linha de entrada se estendendo de uma embarcação de reboque. uma terminação de extremidade dianteira da fita é acoplada em uma extremidade a linha de entrada e a uma extremidade dianteira da fita de sensor. um dispositivo de flutuação é acoplado por uma linha próxima à terminação de extremidade dianteira. um guincho está disposto no dispositivo de flutuação para estender e retrair a linha. um sensor de profundidade está disposto próximo à terminação de extremidade dianteira. um controlador está em comunicação de sinal com o guincho e o sensor de profundidade de modo que a extremidade dianteira da fita é mantida em uma profundidade selecionada no corpo de água.
Patent BR-PI1103283-B1 (BR)
Title: Máquina para colocação de separadores protetores de garrafas contidas em caixas de embalagem
Inventor: CARINA ADRIANA LATTANZI
IPC: B65B61/22
Filed: 2011-07-05
Abstract: máquina para colocação de separadores protetores de garrafas contidas em caixas de embalagem . trata-se de uma máquina concebida para ser incorporada à linha de empacotamento dos recipientes de bebidas, tais como vinhos e espumantes, em uma etapa posterior à de entrada das garrafas na caixa e anterior à do fechamento das mesmas. a máquina se constitui em um bastidor fixo (b) intercalado na linha de embalagem, definindo um setor inferior por onde atravessam as caixas portadoras das garrafas, e um setor superior onde se define uma estrutura horizontal portadora de pelo menos um calço de colocação (c). os separadores (s) são do tipo que compreende pelo menos duas placas laminares flexíveis de formato quadrangular que são unidas entre si através de uma linha de adesão central e vertical disposta entre suas faces enfrentadas. cada calço de colocação (c), que é formado por um trilho alimentador de separadores dobrados (s), fica de frente a um recurso extrator pneumático deslizante, portador de passagens (17) e (18) de sucção e retenção dos separadores de forma unitária, para dispô-los em alinhamento vertical com um conjunto conformador, de acionamento pneumático e verticalmente móvel, constituído por guias de dobra (9) e (9') e que atua combinado com um meio impulsionador vertical acionado por um cilindro pneumático (31), através do qual o separador (s) conformado é colocado entre as garrafas no interior da caixa de embalagem, dispostos um após o outro, dentro de um mesmo bastidor, cada um dos quais possui seu próprio trilho alimentador de separadores.
Patent BR-PI1104033-B1 (BR)
Title: controlador de roda para uma aeronave e aeronave
Inventor: PERRY BÖHME
IPC: B64C25/50
Filed: 2011-08-29
Abstract: CONTROLADOR DE RODA PARA UMA AERONAVE. A presente invenção refere-se a um controlador de roda para uma aeronave, em particular avião, por meio do qual no mínimo uma roda, em particular roda de nariz, pode ser controlada, e na qual o controlador de roda, preferivelmente é um controlador de roda de nariz, ou timão, e a uma aeronave, em particular avião, com no mínimo um controlador de roda.
Patent EA-004269-B1 (EA)
Title: Method for site-specific preparation of conjugates of human growth hormone releasing factor and polyethylene glycol, conjugates, prepared according to that method, use in production of a medicament thereof
Inventor: VERONESE FRANCESCO MARIA
IPC: A61K47/48
Filed: 1998-12-01
Abstract: 1. A method for the site-specific preparation of hGRF-PEG conjugates containing one or more than one PEG units (per hGRF) covalently bound to Lys<12> and/or Lys<21> and/or N<ALPHA>characterized in that the conjugation reaction between the hGRF peptide and the activated PEG is carried out in solution and the desired hGRF-PEG conjugate is isolated from reaction mixture and purified. 2. The method of claim 1, wherein the solution is a concentrated aqueous nicotinamide solution or a buffered aqueous solution of a defolding agent. 3. The method of claim 1, wherein the solvent is a polar organic solvent selected from dimethyl sulfoxide, dimethyl formamide/buffer or acetonitrile/buffer. 4. The method of claim 1, wherein desired hGRF-PEG conjugate is isolated from reaction mixture and purified by chromatographic methods. 5. The method according to any one of the preceding claims, wherein the hGRF peptide is h-GRF(1-29)-NH2. 6. The method of claim 1, wherein, before the pegylation reaction occurs, the hGRF peptide is protected at one or more of the positions: N<ALPHA>, Lys<12> and Lys<21>. 7. The method of claims 1 or 6, which further comprises a de-protection reaction after pegylation with PEG. 8. The method according to anyone of the preceding claims, wherein the activated PEG is an alkylating or acylating PEG in its mono-methoxylated form. 9. A hGRF-PEG conjugate, produced by method according to any of claims 1-8, containing one or more than one PEG units (per hGRF) covalently bound to Lys<12> and/or Lys<21> and/or N<ALPHA>. 10. A hGRF-PEG conjugate according to claim 9, in which 1 PEG chain is covalently bound to Lys<12>. 11. A hGRF-PEG conjugate according to claim 9, in which 1 PEG chain is covalently bound to Lys<21>. 12. A hGRF-PEG conjugate according to claim 9, in which 1 PEG chain is covalently bound to each of Lys<12> and Lys<21>. 13. A hGRF-PEG conjugate according to claim 9, in which 1 PEG chain is covalently bound to each of Lys<12>, Lys<21> and N<ALPHA>. 14. [Lys(Alloc)<12.21>]-hGRF, as intermediate in the pegylation reaction with PEG of claim 1. 15. [N<ALPHA>-isopropyl-Tyr<1>, Lys(Alloc)<12>]-hGRF, as intermediate in the pegylation reaction with PEG of claim 1. 16. Use of the conjugates according to any of the claims from 9 to 13, in the manufacture of a medicament for the therapy and prophylaxis or diagnosis of growth-hormone related disorders. 17. Use according to claim 16, in the manufacture of a medicament for the treatment or diagnosis of growth hormone deficiency.
Patent EA-007179-B1 (EA)
Title: New thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors
Inventor: VERGNE FABRICE
IPC: A61K31/4245
Filed: 2001-10-01
Abstract: The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following formula (I):in which, Y is S or O, R1 is C-Calkyl, C-Calkenyl, C-Calkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or a bicyclic group, optionally substituted, R2 is C-Calkyl or cycloalkyl, optionally substituted,R3 is X-R'3, in which Xis a binding group and R'3 is cycloalkyl, cycloalkenyl, aryl, heterocycle or a polycyclic group optionally substituted or their pharmaceutically acceptable derivatives, the process for their preparation and their use for the manufacture of a medicament for the treatment of disorders for which a treatment by a PDE7 inhibitor is relevant.
Patent EA-006147-B1 (EA)
Title: Mill centrifugal separator
Inventor: LEIKIN VLADIMIR ZINOVIEVICH
IPC: B07B7/08
Filed: 2004-05-07
Abstract: The present invention relates to mill in which planar-prismatic housing (mill, for example) can be connected to cylindrical centrifugally-accelerating separator part dividing raw materials stream. The centrifugal separator comprises a transition zone from the polygonal section profile to the cylindrical section, wherein the transition zone is designed in the form of alternate flat triangular surfaces and rotation surfaces. The rotation surface represents a cone part, the axis of which extends through the polygonal angle and through the center of the cylindrical section, and the conic surfaces are formed by several matrices of the triangular surfaces. The technical result - improving separation conditions, higher efficiency and separation volume and better explosion-proof separator features.
Patent EA-007729-B1 (EA)
Title: Apparatus for hip joint surgery
Inventor: SHERRY EUGENE
IPC: A61B17/56
Filed: 2002-11-01
Abstract: The surgeon grasps the jig (140) by its handle (141) and manipulates the head (210) of the jig through the patient wound and onto the femoral neck (4), as best illustrated in figure 67. The head (210) of the jig (140) includes jig location means in the form of an elongate rod which acts as a spacer (142). The spacer (142) has an end (211) which abuts the trochanteric fossa so as to position the slot (143) of the jig (140) at the required position, which, in the preferred embodiment, is between 5mm and 25mm, and most preferably 15mm, from the trochantic fossa. Additional jig location means are provided by a surface (212) adapted to receive a bone formation. This surface (212) is provided by contours (146) on the base of the head (210) which are adapted to mate with contours of the femur. The slot (143) is oriented generally perpendicularly to the elongate dimension of the rod (142). The slot (143) functions as a surgical tool guide means which is positioned by the jig (140) at the correct position for osteotomisation of the neck (4). Advantageously, osteotomisation takes place whilst the femoral head (3) is still disposed within the acetabulum.
Patent EA-009994-B1 (EA)
Title: Novel quinoline derivatives
Inventor: HONG YUFENG
IPC: C07D407/14
Filed: 2004-12-13
Abstract: The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R, X, X, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
Patent EA-012927-B1 (EA)
Title: Synthesis of boronic ester and acid compounds
Inventor: PICKERSGILL I FRASER
IPC: C07F5/02
Filed: 2005-03-24
Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor-bortezomib.
Patent EA-012112-B1 (EA)
Title: Compounds and methods for inhibiting mitotic progression
Inventor: CLAIBORNE CHRISTOPHER F
IPC: C07D487/00
Filed: 2005-05-12
Abstract: This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
Patent EA-012729-B1 (EA)
Title: Biphenyl and naphthyl-phenyl hydroxamic acid derivatives
Inventor: PISANO CLAUDIO
IPC: C07C259/06
Filed: 2006-05-31
Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumour, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumours.
Patent EA-018035-B1 (EA)
Title: Method for manufacturing articles from titanium alloys
Inventor: DUZ VLADIMIR ANDREEVICH
IPC: B22F3/16
Filed: 2009-10-07
Abstract: The invention relates to powder metallurgy and may be used for manufacturing complex shape components from powders, containing titanium and alloying elements. Cost effective blend which is being compacted at room temperature and sintered consists of: (a) 10-50 weight % of under separated titanium powder, having less than 500 micron particle size being produced from under separated titanium sponge containing up to 2.0 weight % of chlorine and up to 2.0 weight % of magnesium. Cost of under separated titanium powder is considerably below than a cost of powder produced from completely separated sponge: (b) 10-90 weight % hydrogenated titanium powder, which is a mixture of two hydrogenated powders A and B with a different hydrogen content: powder A contains 0.2-1.0 weight % of hydrogen, and powder B contains 2.0-3.9 weight % of hydrogen. Powder with high hydrogen content provides cleaning of under separated titanium powder taking place during heat treatment and sintering, while powder with low hydrogen content provides sufficient green strength and required microstructure and quality of the finished sintered components: (c) up to 90 weight % of commercially pure titanium powder and 5.0-50 weight % of alloying elements: either master alloys or elemental additions. The method includes: (a) blending of under separated titanium powders, commercially pure titanium , hydrogenated titanium powders containing the different quantities of hydrogen and alloying elements, (b) consolidating the blends at room temperature by die-pressing, by direct powder rolling, cold isostatic pressing or injection molding up to green density at least 60% of the theoretical value, (c) additional crushing of hydrogenated titanium powder to fragments during room temperature consolidation under the pressure in the range of 400-960 MPa to produce a more uniform structure with the refined pore structures contributing the healing this refined pores during sintering, (d) chemical cleaning of titanium powder in the green compacts during their heating to up to 300-900°C and holding at the temperatures for at least 30 minutes for the reaction Cl, Mg and oxygen with hydrogen, which is released during the titanium hydride decomposition, (e) heating in a vacuum to sinter in titanium β-phase region at temperatures of 1000-1350°C, holding at temperature for at least 30 min and cooling. New technology allows to control the chemical purity and properties of sintered titanium alloys and to produce the complex shape components at low manufacturing cost.
Patent EA-015644-B1 (EA)
Title: Method of treatment of cartilage disorders
Inventor: GIMONA ALBERTO
IPC: A61K31/18
Filed: 2007-08-24
Abstract: This invention concerns the treatment of cartilage disorder and osteoarthritis in particular. More specifically, it relates to the use of FGF-18 in treatment regimens and for the manufacture of a medicament for the treatment of patients having a cartilage disorder such as osteoarthritis, such as for example knee osteoarthritis or secondary hip osteoarthritis. Specifically provided is a preferred treatment scheme comprising once weekly administration of an FGF-18 compound per treatment cycle.
Patent EA-016424-B1 (EA)
Title: Safety bottle cap
Inventor: PAKHOMOV DMITRIJ IVANOVICH
IPC: B65D49/00
Filed: 2010-05-05
Abstract: A safety bottle cap consists of an external body, a splitter, having inner cavity and pouring orifice, an inner sleeve, made as a removable cap in the upper part, located between external body and splitter, a base with a through channel, connected with splitter and installed in the bottleneck, additionally comprises a control indicting element, which is in interaction with upper part of inner sleeve and external body, and made with a possibility of appearance of the cap on the face surface after first opening. The cap comprises means of axial movement and blocking of control indicating element relatively to the upper part of inner sleeve and external body, excluding their simultaneous rotation and axial movement in initial stage of opening, with a possibility of torque transmission of the upper part of inner sleeve while further continuing the process of opening.
Patent EA-019404-B1 (EA)
Title: Process for coating frozen products
Inventor: ARAMPONGPUN NARUN
IPC: A23G9/24
Filed: 2010-10-08
Abstract: The present invention provides a process for coating frozen confection stick products (20), the process comprising providing a chamber (2) having two open ends (3, 4), two sides (5, 6) and a base (7); providing at least one pair of apertures (10A-10D), wherein one aperture of each pair is located on each side of the chamber, and wherein the apertures are vertical slots; supplying a liquid coating material to each aperture thereby forming curtains of the liquid coating material (14A-14D); and conveying the frozen confection (20) through the chamber with the stick uppermost so that the frozen confection passes through the curtains of coating material. An apparatus for operating the process is also provided.
Patent EA-017193-B1 (EA)
Title: A method and device for making lateral openings out of a wellbore
Inventor: FREYER RUNE
IPC: E21B7/04
Filed: 2009-03-04
Abstract: A method and device for making lateral openings (36) out of a wellbore (6) in a well formation (8) where fluid is made to flow through a motherbore tubular (2) like a completion or production pipe and then through a needle pipe (4) that is aimed at the formation (8), and where the method includes positioning a needle pipe (4) that comprises at least one pipe section (10, 12) inside or outside a motherbore tubular (2); arranging at least one pipe section (10, 12) to be telescopically displaceable with regard to an other pipe (10, 12) or the motherbore tubular (2).
Patent EA-019665-B1 (EA)
Title: Water purifier
Inventor: MARIN ADRIANO
IPC: C02F1/04
Filed: 2010-05-26
Abstract: The present invention relates to a water purifier having a non-drinkable water inlet (I) and a drinkable water outlet (O1), and comprising at least a boiler (8) having a water inlet and a steam outlet, a fluids separating filter (5) operating by flow and float, having an inlet and an outlet, and a heat exchanger (4) adapted to exchange heat between a first and a second separated fluid flows, having an inlet and an outlet for a first water flow to be heated as well as an inlet and an outlet for a second water flow to be cooled; ; the non-drinkable water inlet (I) is coupled to the first flow inlet of the heat exchanger (4), the first flow outlet of the heat exchanger (4) is coupled to the inlet of the fluids separating filter (5), the outlet of the fluids separating filter (5) is coupled to the inlet of the boiler (8), the outlet of the boiler (8) is coupled to the second flow inlet of the heat exchanger (4), the second flow outlet of the heat exchanger (4) is coupled to the drinkable water outlet (O1).
Patent EA-016435-B1 (EA)
Title: Protective structure with a large span transparent cover
Inventor: ALEXEEV SERGEJ PAVLOVICH
IPC: E04B7/10
Filed: 2011-10-18
Abstract: The invention relates to building, in particular, to spatial large span transparent structures and can be used in creation of closed spaces for protection of buildings and areas around them against unfavorable outer effects. A protective structure has at least one span and comprises supports with mounted thereon a spatial large span multi-belt cable structure with a transparent cover. The spatial large span multi-belt structure comprises at least one pre-stressed cable system and overlaps at least one span of the structure; two buildings of different height serve as supports of said cable system; the cable system comprises at least two belts of cables, anchor spacers arranged between the belts of the cable system and first elements adapted to withstand tension and/or compression efforts and arranged between the cables of the corresponding cable system, and the transparent cover is positioned at the upper belt of the cable system.
Patent EA-019144-B1 (EA)
Title: Lock mechanism
Inventor: OEZGEN ERGIN
IPC: E05B15/10
Filed: 2009-08-18
Abstract: The present invention proposes a lock mechanism with at least one linear latching element having a head portion suitable for engaging with a respective door frame lock panel slot in the direction the latch displace to lock the door. Engaging of said head portions with said slots ensure that releasing of the latch by forcibly moving it in the direction of the lock assembly or door frame is prevented. The latches having a regular linear structure according to the present invention are adapted to displace in a rotational manner around their axes by means of a pin secured to the latch body and guided on a non-linear channel to effect rotation.
Patent EA-019756-B1 (EA)
Title: Submarine pipeline towing equipment, system and process
Inventor: GIOVANNINI UMBERTO
IPC: F16L1/16
Filed: 2010-01-20
Abstract: A submarine pipeline towing equipment comprising: a floater (G), of a prismatic shape with a horizontal or vertical axis, with a variable or partially variable buoyancy, whose lower base is at least partially open by means of an opening or hole (WP) to operate as an "air chamber", having: at least one inlet (AP), made up of a valve, through which air is supplied; at least one outlet (RV), made up of a valve, through which air is discharged; an actuator to control the valve to supply air; an actuator to control the valve to discharge air; means for connecting said equipment to the pipeline; means for transferring air to said floater; DEG means for actuating the actuator to control the valve (AP) to supply air in function of a predefined level in the floater; means for actuating the actuator to control the valve (RV) to discharge air in function of the distance of the floater itself from the seabed.
Patent EA-025023-B1 (EA)
Title: Method for brewing beverage and cartridge containing infusible material
Inventor: QUINN ANTHONY EDWARD
IPC: B65D85/804
Filed: 2011-06-23
Abstract: The present invention provides a method for brewing a beverage in a brewing apparatus, wherein a cartridge containing infusible material is connected to a brew chamber and will form the bottom of the brew chamber. By the introduction of air through the filter of the cartridge, water and infusible material are mixed, and an effective brewing process is conducted. After brewing the beverage is discharged into a receptacle through the filter of the cartridge, leaving infusible material behind in the cartridge. The invention also provides a cartridge for use in the method.
Patent EA-023535-B1 (EA)
Title: Aqueous radioprotective pharmaceutical solution composition and method of preventing, reducing or eliminating effects of ionizing radiation
Inventor: MANIAR MANOJ
IPC: A61K31/10
Filed: 2011-03-24
Abstract: The invention provides an aqueous radioprotective pharmaceutical solution composition and a method of preventing, reducing or eliminating the effects of ionizing radiation in a subject who has incurred or is at risk for incurring exposure to ionizing radiation, comprising administering to the subject an effective amount of an aqueous solution composition comprising between about 20 to about 100 mg/ml of the sodium salt of (E)-4-carboxystyryl-4-chlorobenzylsulfone (ON 01210.Na), at least one cosolvent comprising polyethylene glycol (PEG) in an amount between about 25 and about 90% w/v and at least one stabilizing agent comprising Vitamin E-TPGS, wherein the composition has a pH within the range of about 7.0 to about 9.5. The technical effect is providing a stable formulation of a radioprotective composition that prevents the breakdown of the therapeutically active entity, keeps the drug in the solution at the desired pH and can be used for preventing, reducing or eliminating the effects of ionizing radiation.