baber/WOPTO huggingface dataset:
Patent CA-3033475-A1 (CA)
Inventor: KIM YONG SUNG
IPC: C07K14/54
Filed: 2017-08-10
Abstract: La présente invention concerne une protéine fusionnée Fc hétérodimère et une composition pharmaceutique comprenant la protéine fusionnée Fc hétérodimère, dans la protéine fusionnée Fc hétérodimère comprenant une première région Fc et une seconde région Fc d'une paire de régions Fc d'une immunoglobuline tandis que une sous-unité d'une protéine biologiquement active est liée à au moins l'un des N-terminaux ou C-terminaux de la première région Fc et/ou de la seconde région Fc, la première région Fc et la seconde région Fc sont des domaines CH3 modifiés pour favoriser la formation d'un hétérodimère. Dans la protéine fusionnée Fc hétérodimère selon la présente invention, deux sous-unités ou plus forment un complexe protéique, de telle sorte qu'une protéine constituant une protéine biologiquement active peut être fusionnée à Fc dans une forme et une structure d'origine lorsque la protéine existe dans la nature et ainsi la protéine peut maintenir une activité d'origine lorsque la protéine existe dans la nature. L'utilisation de la protéine fusionnée Fc hétérodimère selon la présente invention accroît d'une manière remarquable la demi vie du in vivo d'une protéine biologiquement active contenu dans la protéine fusionnée Fc hétérodimère et ainsi divers types d'activités biologiques peuvent être maintenues pour longtemps dans le corps.
Patent CA-3033680-A1 (CA)
Title: System and method for detection of a stimulated motion reaction
Inventor: INMAN DANA MICHAEL
IPC: A61B5/11
Filed: 2017-08-10
Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.
Patent CA-3033703-A1 (CA)
Title: Suture delivery device for suturing tissue
Inventor: HO SHIH-WEI
IPC: A61B17/062
Filed: 2017-08-10
Abstract: Systems are provided for delivering a suture to close a surgical opening. An elongated deployment member may have at its distal end a retracted counterforce member. The counterforce member may be inserted into the surgical opening and deployed to resist being withdrawn from the opening. A compression member may be slid down the elongated member to compress the tissue to be sutured against the counterforce member. Suture passers loaded with suture ends may be passed through needle tubes within the elongated member to emerge from the elongated member and pierce the tissue to be sutured, then deposit the suture ends with a suture catcher. The suture passers may be withdrawn, leaving the suture ends. The suture catcher may be retracted, retaining the suture ends and the device - elongated member, retracted suture catcher, and retained suture end - may be withdrawn from the surgical opening. The suture may then be completed.
Patent CA-3034910-A1 (CA)
Title: Object detection using image classification models
Inventor: PRICE MICAH
IPC: G06N3/02
Filed: 2019-02-26
Abstract: In one aspect, the present disclosure relates to a method for or performing single-pass object detection and image classification. The method comprises receiving image data for an image in a system comprising a convolutional neural network (CNN), the CNN comprising a first convolutional layer, a last convolutional layer, and a fully connected layer;  providing the image data to an input of the first convolutional layer; extracting multi-channel data from the output of the last convolutional layer; and summing the extracted data to generate a general activation map; and detecting a location of an object within the image by applying the general activation map to the image data.
Patent CA-3037992-A1 (CA)
Inventor: JENSSEN TORE
IPC: F16N11/00
Filed: 2017-10-02
Abstract: A turntable lubrication device for lubricating sliding mating surfaces of a base plate and an upper plate, the device comprising; - a casing, and - a lubricating grease contained and sealed within the casing, which lubrication device is intended to be manually positioned on the mating surface of the base plate and ruptured under pressure of the upper plate when the upper plate is positioned on top of the base plate, thereby allowing the grease to be distributed between the mating surfaces. The lubrication device is elongated and plastically formable, thus allowing the device to be shaped and curved so that it substantially follows a circumferential shape of the base plate such that the grease is evenly distributed over the sliding mating surfaces.
Patent CA-3038537-A1 (CA)
Title: Films etirables multicouches ayant une force d'adherence elevee et procedes correspondants
Inventor: OLIVEIRA MARLOS GIUNTINI DE
IPC: C08L23/14
Filed: 2017-09-11
Abstract: Dans des modes de réalisation, la présente invention concerne des films multicouches comprenant une couche adhésive, une couche centrale et une couche antiadhésive, la couche adhésive comprenant un interpolymère de propylène et la couche centrale comprenant une composition de polyéthylène de couche centrale.
Patent CA-3039146-A1 (CA)
Inventor: NAKANO TAKUMA
IPC: A24F40/51
Filed: 2016-10-05
Abstract: This flavor inhaler is provided with a heating element for atomizing an aerosol source; and a supply member having a discharge port through which the aerosol source is supplied to the heating element. The heating element has a porous structure and is spaced apart from the discharge port.
Patent CA-3048053-A1 (CA)
Inventor: THOMPSON RONALD H
IPC: B60C7/00
Filed: 2017-12-21
Abstract: A wheel (e.g., a caster wheel) for a vehicle or other device, in which the wheel comprises a non-pneumatic tire and may be designed to enhance its use and performance and/or use and performance of the vehicle or other device, including, for example, by being less laterally stiff (e.g., less torsionally stiff) to better manage lateral loading on the wheel (e.g., when the vehicle or other device turns and/or encounters an obstacle, such as a stump, root, curb, etc., at a lateral side of the wheel) and/or by better distributing pressure applied by the wheel onto the ground (e.g., to reduce, minimize or eliminate potential for damaging the ground).
Patent CA-3049154-A1 (CA)
Title: Sounding reference signal power control for multiple input multiple output wireless system
Inventor: ZHANG YI
IPC: H04W52/14
Filed: 2017-01-04
Abstract: A technique includes selecting, by a user device independently for each of a plurality of sounding reference signal resources, an uplink data channel power control parameter set for an uplink data channel beam pair to be used to adjust a sounding reference signal transmission power for a sounding reference signal beam pair, adjusting, by the user device for each sounding reference signal resource based on a selected uplink data channel power control parameter set, asounding reference signal transmission power for a sounding reference signal, and transmitting, by the user device, each of a plurality of power-adjusted sounding reference signals via a corresponding sounding reference signal resource and a corresponding sounding reference signal beam pair.
Patent CA-3049383-A1 (CA)
Title: Compositions et procedes se rapportant a des constructions fc modifiees
Inventor: BOSQUES CARLOS J
IPC: C07K16/46
Filed: 2018-01-05
Abstract: L'invention concerne des constructions Fc d'IgG modifiées et leurs utilisations.
Patent CA-3049569-A1 (CA)
Inventor: HUNDEMER HANK J
IPC: B66D1/48
Filed: 2017-12-21
Abstract: Example dynamically adjustable tether systems are described herein. An example tether system for use with an unmanned aerial vehicle (UAV) may include a base and a vertically-oriented elongate structure having an adjustable height. For instance, the elongate structure may include a lower end, and an upper end. The elongate structure may also couple to the base proximate the lower end. The system may further include a tether that extends from a first coupling-point positioned proximate the upper end of the elongate structure to a second coupling-point positioned on the UAV and a computing system configured for performing a set of acts, such as detecting a change in height of the elongate structure, and causing the tether to be reconfigured within the tether system based on the detected change in height of the elongate structure.
Patent CA-3050157-A1 (CA)
Inventor: ALBERT RINO P
IPC: E04G23/03
Filed: 2019-07-19
Abstract: In various aspects and embodiments a roofing guard device 200 comprises a mount portion 210, brace portion 220, optional lateral supports 240, and restraint flanges 214, 216, as well as optional fall-arrest mount (s) 230. By securely supporting a foot guard 12 such as a board or plank and providing secure attachment points for roofing harnesses 400 or other fall-arrest devices, the roofing guard device 200 provides increased protection against falls and other mishaps.  When configured such that a gap between the foot guard 12 and an edge 101 of the roof 100 is entirely or substantially eliminated, roofing guard devices in accordance with the invention can further help to eliminate dangers from falling tools, hardware, etc.
Patent CA-3054320-A1 (CA)
Inventor: LIN YANAN
IPC: H04L1/16
Filed: 2017-02-24
Abstract: Provided are a method for transmitting feedback information, a terminal device and a network device, wherein same can dynamically adjust a feedback mode used for transmitting feedback information, so that feedback overheads and the utilization rate of transmission resources can be comprehensively considered. The method comprises: a terminal device determining a target feedback mode used for transmitting feedback information, wherein the feedback information is feedback information about a transport block (TB) sent by a network device and received by the terminal device; and the terminal device transmitting the feedback information by using the target feedback mode.
Patent CA-3059449-A1 (CA)
Title: Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
Inventor: JACOBSON IRINA C
IPC: A61K31/519
Filed: 2018-04-24
Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient a safe and effective amount of a compound represented by any of Formulas l-lll, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a safe and effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
Patent CA-3059666-A1 (CA)
Inventor: BAHADUR THAPA SHYAM
IPC: F01N3/30
Filed: 2018-05-24
Abstract: La présente demande concerne une configuration pour une embarcation comprenant une unité de combustion; un système de nettoyage d'un gaz d'échappement pour nettoyer le gaz d'échappement de l'unité de combustion en gaz d'échappement propre; un tuyau d'échappement de gaz propre pour recevoir le gaz propre; un système de gestion du panache comprenant une prise d'air pour prendre l'air ambiant, un radiateur pour chauffer l'air ambiant et un mélangeur à gaz placé dans le tuyau d'échappement de gaz propre pour mélanger ce gaz et l'air chaud, afin de produire un mélange de gaz d'échappement soufflé dans l'atmosphère à l'aide d'une ou plusieurs sorties de gaz d'échappement. La demande concerne également une méthode pour éviter que le gaz d'échappement créé par l'unité de combustion du navire et nettoyé dans le système de nettoyage descende et se dépose sur les zones adjacentes.
Patent CA-3059715-A1 (CA)
Inventor: ROBELL KEVIN
IPC: A01G9/00
Filed: 2018-04-09
Abstract: La présente invention concerne des compositions, des contenants, des systèmes, des ensembles et des procédés associés pour la culture et l'expédition de plantes vivantes et en cours de croissance. Les compositions, les contenants, les systèmes, les ensembles et les procédés associés selon la présente invention permettent d'accroître la stabilité pour un environnement de culture d'une plante et de prolonger la durée de conservation lors du stockage et de l'expédition tout en réduisant ou en éliminant le besoin de réfrigération.
Patent CA-3061250-A1 (CA)
Inventor: DESOUZA CARLITO R
IPC: G01J5/00
Filed: 2019-11-12
Abstract: Il est décrit une méthode et un système de détection dincendies de soufre qui comprennent un capteur de micro-ondes ou un capteur infrarouge à distance pour détecter du gaz de dioxy de soufre et fournir une surveillance dincendies de soufre de jour et de nuit à distance non surveillée; une détection de point chaud, une prévention précoce dincendies de soufre, une détection dincendie de soufre, ou une protection contre les incendies de feu de blocs de soufre combustibles et sans surveillance, des accumulations de soufre, des usines de soufre, ou déquipement utilisant des dispositif de télédétection qui comprend la détection, la mesure et lanalyse de rayonnement électromagnétique afin de déterminer la présence de gaz de dioxy de soufre.
Patent CA-3061945-A1 (CA)
Title: Combination of a cell therapy and an immunomodulatory compound
Inventor: PORTS MICHAEL
IPC: A61P35/00
Filed: 2018-05-01
Abstract: The present disclosure relates in some aspects to methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy, and an immunomodulatory compound, such as a structural or functional analog or derivative of thalidomide and/or an inhibitor of E3-ubiquitin ligase. The provided methods, compositions and uses include those for combination therapies involving the administration or use of one or more immunomodulatory compounds in conjunction with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR)-expressing T cells. Also provided are compositions, methods of administration to subjects, articles of manufacture and kits for use in the methods. In some aspects, features of the methods and cells provide for increased or improved activity, efficacy, persistence, expansion and/or proliferation of T cells for adoptive cell therapy or endogenous T cells recruited by immunotherapeutic agents.
Patent CA-3062936-A1 (CA)
Title: Uplink carrier access
Inventor: NIU LI
IPC: H04W36/36
Filed: 2017-05-17
Abstract: One or more devices, systems, and/or methods for facilitating access to an uplink carrier are provided. For example, information corresponding to a plurality of uplink carriers may be received from a wireless node. An uplink carrier may be selected from the plurality of uplink carriers based upon the information. A request to access the uplink carrier may be transmitted to the wireless node.
Patent CA-3063061-A1 (CA)
Inventor: SHEN YINGJIE
IPC: A61P25/28
Filed: 2017-05-12
Abstract: L'invention concerne des compositions et des méthodes de traitement et de prévention de maladies neurodégénératives, telles que la maladie d'Alzheimer. Dans certains modes de réalisation, la composition comprend un peptide qui coupe la liaison entre la PTPs et l'APP, empêchant le traitement ß-amyloïdogénique de l'APP sans affecter d'autres substrats majeurs des ß- et des ?-secrétases. En variante, dans certains modes de réalisation, un anticorps ou un fragment d'un anticorps dirigé contre la PTPs ou l'APP peut être utilisé pour couper la liaison entre la PTPs et l'APP. Dans certains modes de réalisation, la composition comprend des composés ou des enzymes, qui rétablissent l'équilibre péri-neuronal des ligands CS et HS de la PTPs, ce qui permet d'empêcher un traitement ß-amyloïdogénique anormalement accru de l'APP. Les compositions et les méthodes décrites dans la présente description peuvent être utilisées en association pour traiter et prévenir des maladies neurodégénératives.
Patent CA-3065734-A1 (CA)
Title: Asymmetric opening and closing prosthetic valve leaflet
Inventor: ARMSTRONG JOSEPH R
IPC: A61F2/24
Filed: 2014-12-05
Abstract: A prosthetic valve (100) comprising a plurality of leaflets (130), each leaflet defines a leaflet first side region and a leaflet second side region opposite from the leaflet first side region, each leaflet defining a leaflet base (134) and a leaflet free edge (142) opposite from the leaflet base, each leaflet first side region is coupled with the leaflet second side region of an adjacent leaflet at a commissure (136), the leaflet base of each of the plurality of leaflets together define an orifice, at least a first portion of the leaflet first side region having a first thickness and the second side region having a second thickness, the first thickness is greater than the second thickness. These leaflets move asymmetrically in that a leaflet second side region of the leaflet initially moves toward the open position before a leaflet first side region and the leaflet first side region initially moves toward the closed position before the leaflet second side region. In the fully open position, the leaflet first side region opens less than the leaflet second side region. Asymmetric opening and final open position creates spiral flow. Controlled asymmetric movement of the leaflet reduces closing volume.
Patent CA-3065965-A1 (CA)
Inventor: KOELBLIN CHRISTIAN
IPC: H01B3/44
Filed: 2019-12-20
Abstract: L'invention concerne un câble électrique comprenant une couche semi-conductrice réticulée obtenue à partir d'une composition polymère réticulable à base d'au moins un polymère d'oléfine non polaire, et d'au moins 15% en poids d'un polymère de butène, par rapport au poids total de la composition polymère réticulable.
Patent CA-3066141-A1 (CA)
Inventor: BREEN SCOTT M
IPC: B21D45/04
Filed: 2019-12-26
Abstract: A stock lifter for metal forming dies includes a self-contained assembly. The assembly includes a guide pin that reciprocates within a base. A hardened end cap, which contacts the stock, is attached to the guide pin. A spring is located on the exterior surface of a portion of the base and surrounds the guide pin body. One end of the spring contacts a surface on the cap, while the other end of the spring contacts a surface on the base or an optional mounting flange that is attached above the base. Thus, the stock lifter assembly has a hardened cap for the stock to slide on and a larger, externally mounted spring that provides longer life for the stock lifter. The stock lifter assembly can be made of several different lengths and sizes by using longer or wider guide pins and springs.
Patent CA-3067415-A1 (CA)
Title: Granules
Inventor: BROWN ROBERT P
IPC: B01J13/20
Filed: 2018-06-13
Abstract: Plurality of granules comprising a ceramic core having an outer surface and a shell on and surrounding the core, wherein the shell comprises ceramic particles bound together with an inorganic binder, the inorganic binder comprising reaction product of at least alkali silicate and hardener, wherein the ceramic particles are present as greater than 50 percent by weight of the shell of the respective granule, based on the total weight of the shell of the respective granule, wherein the shell of each granule has a total porosity in a range from greater than 0 to 60 percent by volume, based on the total volume of the shell of the respective granule, wherein the shell of each granule has a volume of at least 40 volume percent, based on the total volume of the respective granule, and wherein the granules have a minimum Total Solar Reflectance of at least 0.7. The granules are useful, for example, as roofing granules.
Patent CA-3067422-A1 (CA)
Title: Systems and methods for determining microsatellite instability
Inventor: ZHANG SHILE
IPC: G16B20/20
Filed: 2018-11-14
Abstract: Presented herein are techniques for determining microsatellite instability. The techniques include generating a reference sample dataset representative of or mimicing a hypothetical matched sample for an individual sample of interest. The reference sample dataset may be generated from a set of reference normal samples that are not matched to the sample of interest. For samples of interest lacking a matched sample, the reference sample dataset may be used to determine microsatellite instability and to provide an indication of a presence, absence, or degree of microsatellite instability of the sample of interest. The reference sample dataset may be generated such that individual microsatelliate regions associated with a high degree of variability between ethnic groups are filtered out, masked, or otherwise not considered.
Patent CA-3068622-A1 (CA)
Inventor: OH YOUNGHOON
IPC: C12N15/864
Filed: 2018-06-29
Abstract: L'invention concerne des méthodes de purification, de production et de fabrication de particules recombinantes de vecteur viral adéno-associé (rAAV). Les méthodes de purification, de production et de fabrication selon l'invention font par exemple appel à au moins 2 étapes de chromatographie en colonne. Les étapes de chromatographie en colonne comprennent, par exemple, la chromatographie par échange de cations, la chromatographie par échange d'anions, la chromatographie par exclusion de taille et/ou la chromatographie par affinité d'AAV seule ou en combinaison et dans n'importe quel ordre.
Patent CA-3074696-A1 (CA)
Title: Non-occluding balloon for cardiovascular drug delivery
Inventor: SITHARAM RAMANATH VIJAY
IPC: A61M25/10
Filed: 2018-10-02
Abstract: A non-occluding drug-coated balloon catheter device for use in a blood vessel transporting blood comprises a catheter shaft including a guidewire lumen, a fluid lumen and a connector port. A balloon is mounted on the catheter shaft and includes an outer envelope surrounding the guidewire lumen in fluid communication with the fluid lumen; a drug coating applied on the exterior surface of the outer envelope; and at least one bypass lumen forming a passage extending from the proximal end of the outer envelope to the distal end of the outer envelope. When the balloon is positioned in a blood vessel and inflated, the exterior surface of the outer envelope presses the drug coating against the blood vessel and the bypass lumen is open between the distal end of the outer envelope and the proximal end of the outer envelope such that blood transport continues through the bypass lumen.
Patent CA-3081781-A1 (CA)
Inventor: RAVELLI EMMANUEL
IPC: G10L19/03
Filed: 2018-11-06
Abstract: There are discussed methods and apparatus for performing temporal noise shaping. An apparatus may comprise a temporal noise shaping, TNS, tool (11) for performing linear prediction, LP, filtering (S33, S35, S36) on an information signal including a plurality of frames; and a controller (12) configured to control the TNS  tool (11) so that the TNS tool (11) performs LP filtering with:  a first filter (14a) whose impulse response has a higher energy (S36); and a second filter (15a) whose impulse response has a lower energy (S35) than the first filter, wherein the second filter is not an identity filter, wherein the controller (12) is configured to choose (S34) between filtering (S36) with the first filter (14a), and filtering (S35) with the second filter (15a) on the basis of a frame metrics.