baber/WOPTO huggingface dataset:
Patent DK-0898562-T3 (DK)
Inventor: JACOBSEN E JON
IPC: A61K31/415
Filed: 1997-03-03
Granted: 2003-05-12
Abstract: The present invention provides novel hydroxamic acid derivatives represented by the compound of formula I    <IMAGE>  I  or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
Patent DK-0939810-T3 (DK)
Inventor: GRONEMEYER HINRICH
IPC: C07K14/47
Filed: 1997-07-11
Granted: 2007-04-10
Abstract: The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
Patent DK-0989131-T3 (DK)
Inventor: SUEOKA HIROYUKI
IPC: C07D495/14
Filed: 1997-08-11
Granted: 2003-03-03
Abstract: Thienotriazolodiazepine compounds of the formula (1) <CHEM> wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof or hydrates thereof, and pharmaceutical agents containing this compound, a pharmaceutically acceptable salt thereof or a hydrate thereof. A pharmaceutical agent containing the inventive compound is useful as a therapeutic agent, a preventive drug or a recurrence preventive drug for inflammatory bowel diseases caused by cell adhesion, such as ulcerative colitis and Crohn's disease. In addition, the inventive compound can be used for the prophylaxis and treatment of venous insufficiency and venous ulcer or maintained remission of the both. Moreover, inasmuch as the low toxicity of the inventive compound has been established by experiments using animals, the compound is useful as a highly safe pharmaceutical product.
Patent DK-0864565-T3 (DK)
Inventor: RODUIT JEAN-PAUL DR
IPC: C07D213/79
Filed: 1998-03-10
Granted: 2002-09-16
Abstract: Preparation of 2,6-pyridine-dicarboxylic acid esters of formula (I) comprises reaction of a 2,6-dihalopyridine of formula (II) with carbon monoxide and an alcohol of formula (III) in the presence of a base and a catalyst complex from palladium and a bis-diphenylphosphine derivative of formula (IV). R1-OH (III). R1 = 1-6C alkyl, 3-6C cycloalkyl, aryl or aralkyl; R2, R3 = H or Cl; R4 = H, 1-6C alkyl, 1-6C alkoxy or F; X = Cl or Br; Q = 3-6C alkanediyl or 1,1'-ferrocenediyl (optionally containing cyclopentadienyl groups substituted by 1-4C alkyl or aryl); R5-R8 = H, 1-4C alkyl, 1-4C alkoxy, CH2F, CHF2, CF3, F, aryl, aryloxy, CN or N(alkyl)2.
Patent DK-0897914-T3 (DK)
Inventor: SPURR PAUL
IPC: A61K31/535
Filed: 1998-08-10
Granted: 2004-09-27
Abstract: The present invention concerns a process for the preparation of a 2,5-disubstituted pyridine of the formula (I) <CHEM> which comprises the steps of a) reacting a compound of the formula (II) R<1>-CH=CH-R<2> with an acrylic compound of the formula (III) <CHEM>  to form a compound of the formula (IV) <CHEM> and b) reacting the compound of formula (IV) under water free conditions with a hydrogen halide in which formulae R<1> signifies lower alkyl, R<2> signifies di-(lower alkyl)amino or a 5- or 6- membered -N-heterocyclyl group having the free valence bond at the nitrogen atom, and X signifies halogen.
Patent DK-0981631-T3 (DK)
Inventor: BLINKOVSKY ALEXANDER
IPC: A23L27/21
Filed: 1998-05-15
Granted: 2007-08-06
Abstract: The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
Patent DK-0960300-T3 (DK)
Inventor: CAMBOT-COURRAU YVES
IPC: F16L33/22
Filed: 1998-12-08
Granted: 2002-09-16
Abstract: PCT No. PCT/FR98/02654 Sec. 371 Date Jun. 28, 1999 Sec. 102(e) Date Jun. 28, 1999 PCT Filed Dec. 8, 1998 PCT Pub. No. WO99/30071 PCT Pub. Date Jun. 17, 1999The invention relates to a quick-coupling device for coupling a tube to a rigid element (50) having a bore, the device comprising a tubular insert (1) having means (7) enabling it to be anchored in the bore of the rigid element (50), declutchable tube retaining means (11), and a slide (13) mounted to move in translation in the tubular insert (1) to declutch the retaining means (11) when it is pushed into the tubular insert (1). The declutching slide (13) possesses a rear portion which projects outside the tubular insert (1) and which presents a shoulder surface (23) situated facing an end surface (24) of the tubular insert (1) and co-operating with said end surface to define a groove in which a removable intermediate ring (25) is received to oppose pushing in of the declutching slide (13).
Patent DK-1041995-T3 (DK)
Inventor: GREENWALD RICHARD B
IPC: C07C271/16
Filed: 1998-12-29
Granted: 2006-07-10
Abstract: The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: wherein: B is a leaving group or a residue of an amine-containing target moiety; G is or CH2; Y1-2 are independently O or S; M is X or Q; where X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y2); R1, R4, R7, R8, R9, R10 and R13 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls; R2, R3, R5 and R6 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C1-6 alkoxy, phenoxy, C1-8 heteroalkyls, C1-8 heteroalkoxy, substituted C1-6 alkyls, C3-8 cycloalkyls, C3-8 substituted cycloalkyls, aralkyls, aryls, substituted aryls, such as aryls substituted with halo-, nitro- and cyano-; carboxy-, C1-6 carboxyalkyls and C1-6 alkyl carbonyls; (m) is zero or one; (n) is zero or a positive integer; (p) is zero, one or two; and R11 is a substantially non-antigenic polymer. The first prodrug is generated when the polymeric portion of the double prodrug is cleaved and the parent molecule is generated rapidly thereafter in vivo, as a result of a trialkyl lock type lactonization-type reaction.
Patent DK-0962658-T3 (DK)
Inventor: LIFSON ALEXANDER
IPC: F25B49/02
Filed: 1999-05-10
Granted: 2008-03-03
Abstract: A method is disclosed for identifying when a compressor is being run in reverse due to improper wiring. In a preferred embodiment, sensors sense the condition of a refrigerant at the inlet line and a refrigerant at the outlet line. If an expected pressure differential is not seen, then the determination is made that the compressor is running in reverse. In embodiments the control system may shut down the compressor, provide an alarm, or reverse a phase of two of the three wires of a three phase power input to correct the rotation direction. <IMAGE>
Patent ES-2246201-T3 (ES)
Title: Dispositivo para la extraccion de una sustancia.
Inventor: KOLLEP ALEXANDRE
IPC: A47J31/00
Filed: 2000-05-09
Granted: 2006-02-16
Abstract: Dispositivo para la extracción de una sustancia para la preparación de una bebida a partir de un cartucho (33), que comprende, - un chasis con un zócalo (16), una parte vertical (17) sobre dicho zócalo y una parte horizontal (18) dispuesta a una cierta distancia del zócalo, - un cajón móvil (19) - un sistema de elementos (21) para recibir la cápsula y permitir el flujo de la bebida, y - un sistema de extracción (24) móvil hacia dicho sistema de elementos para aprisionar y extraer el cartucho, caracterizado porque la parte horizontal (18) comprende un sistema de elemento (21); estando el sistema de extracción (24) dispuesto por encima del sistema de elemento (21), y porque el cajón móvil (19) está configurado para deslizar sobre la parte horizontal (18) de manera a traer una primera cápsula (33) hasta su posicionamiento sobre el sistema de elementos, y permitir un retorno en posición inicial para la colocación de una segunda cápsula (34) guardando a la vez la primera cápsula sobre el sistema de elemento (21).
Patent ES-2276659-T3 (ES)
Inventor: NOWACK ULRICH DIPL-ING
IPC: B23K9/04
Filed: 2000-10-10
Granted: 2007-07-01
Abstract: The reinforcing structures are bonded-on additively. They are additional coating structures (16). They are held on principal areas (12) of the component (10). An Independent claim is included for the corresponding flat component. Preferred features: Position, dimensions and contours of the coating structure are calculated from guidelines for stiffness of a set region (20) of the component. The additional structure is hot- or cold-adhered. It can be produced by plastic spraying. It comprises symmetrical segments, especially symmetrical about a central point. The coating structure is plastic or metal. Segments all have the same height. They alternatively rise or fall linearly or progressively in height, towards the center.
Patent ES-2179805-T3 (ES)
Inventor: HOFESTADT HOLM DR
IPC: B61L29/18
Filed: 2000-01-06
Granted: 2003-02-01
Abstract: The method involves, on detecting a request (Anf. 1) from a second train (Z2) approaching the crossing and before switching on the crossing for a first transition, delaying a train (Z1) which would usually be first to switch-on/reach the crossing so that the switch-on/occupation time occurs at the earliest at the switch-on time and its switch-off/vacation time at the latest at the switch-off time of the other train passing through the crossing.
Patent ES-2215636-T3 (ES)
Inventor: ESKILDSEN CHRISTIAN
IPC: F24C15/20
Filed: 2000-05-01
Granted: 2004-10-16
Abstract: Known cooker hoods may be controlled by a combination of sensors, such as for humidity and temperature, and commence increased action when thresholds are exceeded. Some sensors may be sensitive to particular compounds in gas form. Such combinations only react to a very specific range of chemical substances and are sensitive to contamination. According to one embodiment of the invention three sensors are used, the first sensor being sensitive to water vapour but not sensitive to grease and fat vapours, the second sensor being sensitive to both water vapour and to fat vapour, with opposing reactions, and the third having a high sensitivity to fat vapours, and a low sensitivity to water vapour. The sensors are all mounted above the grease filter and below the fan impeller.
Patent ES-2209882-T3 (ES)
Inventor: MCNEIGHT DAVID LESLIE
IPC: A61K9/00
Filed: 2000-05-11
Granted: 2004-07-01
Abstract: A delivery system for nicotine including nicotine encapsulated in a microcapsule system which releases the encapsulated nicotine on contact of the microencapsules with a nicotine solvent.
Patent ES-2257296-T3 (ES)
Inventor: LEEMAN AARON H
IPC: A61P31/00
Filed: 2000-05-05
Granted: 2006-08-01
Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula:wherein Ar is aryl and heteroaryl; L is -C(O)N(Q)CH2-, or -CR10R11OCR12R13-; Q is hydrido, -(CH2)mCO2H and -(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.
Patent ES-2218279-T3 (ES)
Title: 3-(4,5-dihidroisoxazol-5-il)benzoilpirazoles.
Inventor: BAUMANN ERNST
IPC: A01N43/80
Filed: 2000-12-19
Granted: 2004-11-16
Abstract: 3-(4, 5-dihidroisoxazol-5-il)benzoilpirazoles de la **fórmula**, en la que las variables tienen el siguiente significado: R1, R2 hidrógeno, nitro, halógeno, ciano, alquilo con 1 a 6 átomos de carbono, alquilo halogenado con 1 a 6 átomos de carbono, alcoxi con 1 a 6 átomos de carbono, alcoxi halogenado con 1 a 6 átomos de carbono, alquiltio con 1 a 6 átomos de carbono, alquiltiohalogenado con 1 a 6 átomos de carbono, alquilsulfinilo con 1 a 6 átomos de carbono, alquilsulfinilo halogenado con 1 6 átomos de carbono, alquilsulfonilo con 1 a 6 átomos de carbono, o alquilsulfonilo halogenado con 1 a 6 átomos de carbono; R3 hidrógeno, halógeno o alquilo con 1 a 6 átomos de carbono; R4 hidrógeno o alquilo con 1 a 4 átomos de carbono; R5, R6 hidrógeno, halógeno, ciano, nitro, alquilo con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono-alquilo con 1 a 4 átomos de carbono; así como sus sales útiles en agricultura.
Patent ES-2194805-T3 (ES)
Inventor: BEICHL STEFAN
IPC: F16J15/3288
Filed: 2001-02-28
Granted: 2003-12-01
Abstract: Brush for a brush seal, having a plurality of ceramic fibers, which are held with a part of their length in an integrally continuous material in a matrix forming a solid. The matrix is made at least extensively of carbon, which is made by pyrolysis of a synthetic resin (precursor resin).
Patent ES-2252110-T3 (ES)
Inventor: LUTZ CHRISTIAN
IPC: B62D1/18
Filed: 2001-06-15
Granted: 2006-05-16
Abstract: The length and height adjustment device has a console part (1) secured to the vehicle chassis, a guide part (2) locating an axially displaced fixing bolt (7) and a mantle sleeve (3) for length adjustment of the steering column in the axial direction of the steering spindle (5). Locking devices for the length and height adjustment are opened and closed in common by a clamping mechanism provided by the fixing bolt and a cooperating fixing element.
Patent ES-2225359-T3 (ES)
Title: Metodo de tratamiento por refino de una mezcla de reaccion liquida obtenida a partir de la reaccion de epoxidacion de 1,5,9-ciclododecatrieno.
Inventor: NINOMIYA KOUHEI
IPC: C07B61/00
Filed: 2001-06-29
Granted: 2005-03-16
Abstract: Un método de tratamiento por refino de una mezcla de reacción líquida obtenida a partir de una reacción de epoxidación de 1, 5, 9-ciclododecatrieno con peróxido de hidrógeno en presencia de un catalizador que comprende un compuesto de tungsteno, una sal de onio cuaternario y un ácido mineral, y que contiene 1, 2-epoxi-5, 9- ciclododecadieno resultante, el catalizador, peróxido de hidrógeno sin reaccionar y 1, 5, 9-ciclododecatrieno sin reaccionar, método que comprende separar en fases dicha mezcla de reacción líquida en una fracción en fase oleosa y una fracción en fase acuosa y recoger la fracción en fase oleosa, caracterizado por tratar por refino la fracción en fase oleosa recogida de la mezcla de reacción líquida directamente con una solución acuosa alcalina, para desactivar y retirar de ese modo el peróxido de hidrógeno sin reaccionar y el catalizador contenido en la fracción en fase oleosa de la mezcla de reacción líquida.
Patent ES-2239084-T3 (ES)
Inventor: VILADOT PETIT JOSEP-LIUIS
IPC: D06L4/00
Filed: 2001-09-10
Granted: 2005-09-16
Abstract: Polyamide microcapsules are obtained by contacting aqueous phases containing diamines and anionic polymers and/or heteropolysaccharides in dissolved form with oil phases containing dissolved dicarboxylic halides to form a W/O emulsion, hardening with a calcium salt solution, and filtering, washing and drying. Polyamide microcapsules of average diameter 0.1-5 mm are claimed, being obtained by: (1) contacting: (a) aqueous phases containing: (i) diamines and (ii) anionic polymers and/or heteropolysaccharides in dissolved form; with (b) oil phases containing dissolved dicarboxylic halides to form a W/O emulsion and cause interfacial microcapsule formation; (2) hardening the filtered and washed capsules with a calcium salt solution; and (3) filtering, washing and drying. An Independent claim is also included for production of the microcapsules by steps (1) - (3) as above.
Patent ES-2232554-T3 (ES)
Title: Piloto para vehiculos.
Inventor: HAMELBECK ANTONIUS
IPC: B60Q1/26
Filed: 2001-09-12
Granted: 2005-06-01
Abstract: Piloto, en especial un piloto trasero para vehículos de motor, con una pieza de sujeción a fijarse a la carrocería que, con al menos una brida, puede enchufarse sobre una pieza de fijación dispuesta en la carrocería y que presenta al menos una pieza de asiento, que puede unirse a la carrocería, caracterizado porque la brida (4) presenta un orificio rasgado (7) y porque la pieza de asiento (3) presenta un casquete esférico (19) abierto mediante una abertura lateral (18) en la dirección de dilatación del orificio rasgado (7), en el que está dispuesta, de forma que puede acoplarse por detrás o enclavarse, una cabeza esférica (17) dispuesta en la carrocería (3) de un perno esférico (16).
Patent ES-2218351-T3 (ES)
Inventor: NORMANT EMMANUEL
IPC: A61P3/10
Filed: 2001-09-28
Granted: 2004-11-16
Abstract: The present invention relates to methods of screening compounds that modulate lipid kinases activity. The invention is more preferably based on the SPA technology to screen compounds that modulate the activity of lipid kinases, in particular membrane lipid kinases, more specifically sphingosine kinases. The invention also includes compositions, products, kits, etc for use in performing the above methods, as well as the compounds identified by said methods, and their uses. <IMAGE>
Patent ES-2288508-T3 (ES)
Inventor: NYBERG KAISA
IPC: H04L9/32
Filed: 2001-03-26
Granted: 2008-01-16
Abstract: To provide reliable and customized authentication, a parameter to be used in authentication is defined for the operator. A secret which may be stored e.g. in a subscriber identity module is calculated from the operator parameter and a subscriber key. An authentication response is calculated from the secret and the challenge to be used in authentication with a one-way function.
Patent ES-2278749-T3 (ES)
Title: Metodo para analizar mezclas de sustancias.
Inventor: EPPICH BERND
IPC: G01N21/31
Filed: 2001-04-06
Granted: 2007-08-16
Abstract: Método para analizar mezclas de sustancias basado en la absorción, reflexión o espectroscopia de emisión, c a r a c t e r i z a d o p o r q u e (i) se utilizan aproximadamente tantos canales fotoeléctricos de detección espectralmente filtrados como parámetros de variables espectroscópicamente activos hay dentro de dicha mezcla, (ii) se obtienen las señales fotoeléctricas máximas de salida y la máxima relación señal a ruido en dichos canales de detección, utilizando filtros espectrales binarios que tienen una transmisión que esencialmente asume solamente los valores de Uno y Cero. (iii) se consigue un cambio máximo en las señales fotoeléctricas de salida para un cambio dado en la concentración de al menos una sustancia de interés en dicha mezcla, aplicando un algoritmo de optimización iterativo de filtros espectrales basado en matrices, que procesa datos de calibración obtenidos de dicha mezcla de sustancias, en condiciones de cambios de parámetros conocidos.
Patent ES-2273855-T3 (ES)
Title: Tecnicas pra mejorar la ganancia en redes de rejilla cuasiopticas.
Inventor: ROSENBERG JAMES J
IPC: H01Q15/24
Filed: 2001-06-05
Granted: 2007-05-16
Abstract: Un método de mejorar la ganancia de una celda unitaria (100) de amplificador diferencial de estructura de red de rejilla cuasióptica incluyendo: (a) proporcionar una primera red activa (110) movida por una señal de entrada de una magnitud y polaridad dadas, incluyendo la primera red un puer- to de entrada de señal (112), un puerto de salida de señal (114), un puerto de entrada de realimenta- ción (116) y un puerto de salida de realimentación (118); (b) proporcionar una segunda red activa (150) conectada a la primera red, incluyendo la segunda red un puerto de entrada de señal (152), un puerto de salida de señal (154), un puerto de entrada de realimentación (156), y un puerto de salida de re- alimentación (158), y siendo movida por una señal de entrada que es igual y opuesta a la señal de en- trada de la primera red activa; (c) aplicar al puerto de entrada de realimenta- ción de la primera red activa, mediante un recorri- do de realimentación, una señal de refuerzo deriva- da del puerto de salida de realimentación en una de las redes activas de la celda unitaria; y (d) aplicar al puerto de entrada de realimenta- ción de la segunda red activa, mediante un recorri- do de realimentación, una señal de refuerzo deriva- da del puerto de salida de realimentación en la otra de las redes activas de la celda unitaria.
Patent ES-2252257-T3 (ES)
Inventor: FANG LAWRENCE Y
IPC: C07D215/12
Filed: 2001-06-29
Granted: 2006-05-16
Abstract: The present invention is substituted amine s of formula (XV) useful in treating Alzheimer's ease and other similar disease.
Patent ES-2309085-T3 (ES)
Inventor: JARIWALLA RAXIT J
IPC: A61K31/704
Filed: 2001-08-24
Granted: 2008-12-16
Abstract: The effect of cancer chemotherapeutic agents is potentiated by combination with mineral ascorbates, Vitamin C metabolites and/or Vitamin C-derived furanones.
Patent ES-2243552-T3 (ES)
Title: Mezclador cerrado termo-regulador.
Inventor: PRONI ANTONIO
IPC: B29B7/28
Filed: 2001-08-27
Granted: 2005-12-01
Abstract: Procedimiento para mezclar un compuesto en un mezclador de tandas cerrado, que incluye las fases de - predeterminar un valor mínimo de temperatura del cuerpo del mezclador para iniciar el ciclo de mezcla; - predeterminar una temperatura de precalentamiento del sistema de regulación térmica del mezclador como Punto de Ajuste 1; - predeterminar una temperatura de trabajo del sistema de regulación térmica del mezclador como Punto de Ajuste 2; - predeterminar la histéresis térmica del cuerpo del mezclador; - predeterminar un Punto de Rotura A de la temperatura del cuerpo del mezclador para conmutar el sistema de regulación térmica del mezclador del Punto de Ajuste 1 al Punto de Ajuste 2; - predeterminar un Punto de Rotura B de la temperatura del cuerpo del mezclador para conmutar el sistema de regulación térmica del mezclador del Punto de Ajuste 2 al Punto de Ajuste 1; - medir directamente, en tiempo real de manera continua, la temperatura del cuerpo del mezclador; - comparar la temperatura delcuerpo del mezclador con las temperaturas del Punto de Rotura A y B predeterminadas; y - conmutar el sistema de regulación térmica del mezclador desde un Punto de Ajuste al otro como resultado de la comparación anterior.
Patent ES-2273898-T3 (ES)
Inventor: JACOBSEN BENT
IPC: D04H1/732
Filed: 2001-08-02
Granted: 2007-05-16
Abstract: An MMVF batt is formed by cross lapping an MMVF web to a width of at least 3 metres and curing the batt by passing through a curing oven which is at least 3 metres wide. Rolls or other pieces having a length of at least 3 metres are formed by cutting the batt transversely.