baber/WOPTO huggingface dataset:
Patent EP-4241278-A2 (EP)
Title: Car t cell therapy in patients who have had prior anti-cancer alkylator therapy
Inventor: RYTLEWSKI JULIE ANN
IPC: G16H20/10
Filed: 2021-11-03
Abstract: Provided herein are uses of chimeric antigen receptors (CARs) for treating a tumor or a cancer (such as B cell related cancer, e.g., multiple myeloma). In addition, an optimal washout period for commencing a therapy for the treatment of a condition in a subject after a prior exposure can be determined by receiving, for each of a plurality of subjects, prior treatment history data. Left-censored data can then be derived from the prior treatment history data for each of the subjects that includes a washout period and event or censor. A time scale of the left- censored treatment data is then inverted to result in right-censored treatment data. The right- censored treatment data is then applied to a time-to-event (TTE) model that associates one or more variables of interest with a time since exposure to the prior exposure. A maximally selected log-rank statistic across a plurality of cutoffs within a pre-defined percentile range is computed for continuous variables within the one or more variables of interest. One or more variables and associated cutoffs for the continuous variables having a maximally selected log- rank statistic below a first pre-defined threshold are then identified. A test statistic of each (n-1) strata relative to a reference stratum is then computed for ordinal or categorical variables within the one or more variables of interest. One or more ordinary or categorical variables and associated strata having a test statistic below a second pre-defined threshold, relative to the reference stratum are identified. An optimal washout period is then determined for the therapy based on the cutoff having a lowest value below the pre-defined threshold and relative to a median of subject values below the pre-defined threshold and a median of subject values above the pre-defined threshold.
Patent EP-4248445-A2 (EP)
Inventor: ABECASIS GONCALO
IPC: G16B20/20
Filed: 2021-11-19
Abstract: The present disclosure provides methods for manufacturing nucleic acid probes for genotyping by sequencing, methods for genotyping a DNA sample by sequencing using a set of nucleic acid probes, and systems for carrying out such methods.
Patent EP-4229349-A2 (EP)
Inventor: GEISSELE WILLIAM H
IPC: F41A5/26
Filed: 2021-10-13
Abstract: An assembly for directing propellant gas to an action of a firearm includes a barrel and a gas block. The barrel has a plurality of gas ports that communicate with the bore of the barrel. The barrel and the gas block define a passage that receives pressurized propellant gas from the bore by way of the barrel gas ports, and directs the propellant gas to a gas port of the gas block. The plurality of barrel gas ports and the passage act as a manifold in which the propellant gas is taken from multiple locations within the barrel, combined into a single flow, and directed into the gas block via the gas block gas port. The pressurized gas is then routed to an action of the firearm by way of a gas tube and a gas key.
Patent EP-4198125-A2 (EP)
Title: Pif1-like helicase and use thereof
Inventor: ZHANG ZHOUGANG
IPC: C12N9/90
Filed: 2022-06-22
Abstract: The present application provides a Pifl -like helicase and the use thereof, specifically a modified Pifl -like helicase, a construct comprising the Pif1-like helicase, and its use in characterising a target polynucleotide or controlling the movement of a target polynucleotide through a pore. The present application also provides a method for characterising the target polynucleotide or controlling the movement of the target polynucleotide through the pore. The Pifl-like helicase of the present application can effectively control the movement of the polynucleotide through the pore.
Patent EP-4130617-A2 (EP)
Inventor: CHO YONGBUM
IPC: F25D21/00
Filed: 2022-08-01
Abstract: A refrigerator and a method of controlling an operation thereof are proposed. In the refrigerator and method thereof, heat control of heaters (610, 620) for preventing a damper (520) from freezing is performed according to at least any one condition set in consideration of a room temperature and refrigerator internal humidity. Accordingly, consumption of power due to unnecessary heat generation of the heaters may be reduced, thereby improving the power consumption.
Patent EP-4207800-A2 (EP)
Title: Loudspeaker assembly with a waveguide
Inventor: DAFTUAR RISHI
IPC: H04R1/34
Filed: 2022-12-29
Abstract: In at least one embodiment, a loudspeaker assembly is provided. The loudspeaker assembly includes a loudspeaker and a waveguide. The loudspeaker includes a diaphragm to transmit an audio output. The waveguide being asymmetrical and at least partially surrounding the diaphragm. The waveguide being configured to control a directivity of the audio output.
Patent EP-4294727-A2 (EP)
Inventor: BARTSCH ERIC RICHARD
IPC: B64D35/08
Filed: 2022-02-22
Abstract: A hybrid powertrain system includes an engine, an electric machine having a power shaft therein, and a clutch configured to releasably engage an output of the engine and the power shaft of the electric machine. The electric machine further includes an electrical output. The power shaft is configured to mechanically attach to and provide mechanical power to a propulsion device. A controller is configured to control the engine, the electric machine, and the clutch to implement one or more power output modes.
Patent EP-4241735-A2 (EP)
Title: Heart valve prosthesis fixed through interventricular septum
Inventor: LV SHIWEN
IPC: A61F2/24
Filed: 2017-10-23
Abstract: The invention relates to a heart valve prosthesis (100, 200, 300, 400, 500) anchored to an interventricular septum (183, 383) and conveying and releasing method thereof. The heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313). The valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520), and the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515), one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal end of the valve stitching section (112, 212, 312, 412, 512), and another end of the fixing and supporting section (114, 214, 314, 514) is connected to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and prevent the heart valve prosthesis (100, 200, 300, 400, 500) from axially moving.
Patent EP-4241875-A2 (EP)
Inventor: PSARAS DIMITRIOS
IPC: B01D53/94
Filed: 2015-09-04
Abstract: The present invention relates to a composition comprising zirconium oxide, cerium oxide and one or more other rare earth oxides other than cerium oxide and optionally yttrium, wherein: (i) the composition has a total pore volume from 0.65 to 3.20 cc/g; and (ii) the composition has a BET surface area from 1.9 to 5.2 m<sup>2</sup>/g after calcinations at 1200 degrees Celsius for a period of 10 hours or more in an oxidizing environment, a BET surface area from 24 m<sup>2</sup>/g to 29 m<sup>2</sup>/g after calcination at 1100 degrees Celsius for a period of 10 hours in an oxidizing environment, and a BET surface area from 50 m<sup>2</sup>/g to 65 m<sup>2</sup>/g after calcination at 1000 degrees Celsius for a period of 10 hours in an oxidizing environment, wherein the BET surface area is determined by the procedure outlined in ASTM International test method D 3663-03, reapproved 2008, wherein the application of the BET equation is limited to the pressure range where the term n<sub>a</sub>(1-P/P<sub>o</sub>) of the BET equation continuously increases with P/P<sub>o</sub>, and wherein the outgassing of the sample is done under nitrogen at 300°C for 2 hours.
Patent EP-4283837-A2 (EP)
Title: Co-polar magnet generator
Inventor: DURSUN YILMAZ
IPC: H02K1/27
Filed: 2023-05-23
Abstract: The aim of this invention is to minimize the magnetic forces with co-polar magnets and to minimize the mechanical force (2) applied to the rotor (5).
Patent EP-4272720-A2 (EP)
Inventor: TUNG WAYNE YI-WEI
IPC: A61H1/02
Filed: 2019-01-09
Abstract: A trunk supporting exoskeleton comprises: a supporting trunk; thigh links configured to move in unison with a wearer's thighs; and first and second torque generators located on both left and right halves of the wearer substantially close to the wearer's hip. The torque generators couple the supporting trunk to the thigh links, and generate torque between the thigh links and the supporting trunk. When the wearer bends forward such that a predetermined portion of the supporting trunk passes beyond a predetermined angle from vertical, a torque generator(s) imposes a resisting torque between the supporting trunk and the thigh link(s), causing the supporting trunk to impose a force against the wearer's trunk, and the thigh link(s) to impose a force onto the wearer's thigh. When the predetermined portion does not pass beyond the predetermined angle, the torque generators impose no resisting torques between said supporting trunk and respective thigh links.
Patent EP-4239905-A2 (EP)
Title: Configuration for beam failure recovery
Inventor: ZHOU HUA
IPC: H04B7/06
Filed: 2019-03-29
Abstract: Systems, apparatuses, and methods are described for wireless communications. A base station may send configuration information for a beam failure recovery (BFR) procedure. A wireless device may determine, based on the configuration information, one or more transmission beam parameters for the BFR procedure. The wireless device may indicate, via an uplink control channel, one or more candidate beams of the base station.
Patent EP-0030327-A2 (EP)
Inventor: GUGGENBUEHLER MAX
IPC: A23L27/21
Filed: 1980-11-26
Abstract: A process in which a liquid or pasty mixture containing at least one source of free amino acids and additives comprising at least one monosaccharide and, where desired, at least one sulphur-containing substance is reacted by heating. The source of free amino acids is subjected in liquid form to fractionation on a column of active carbon, some of the fractions are collected, a mixture of the fractions collected and the additives is prepared, the mixture is reacted by heating, an aromatic fraction is removed from the reaction product and/or fixed and the reaction product is dried in vacuo. The product, which has a flavor resembling in taste meat, fish or mushrooms, may be incorporated in food products such as soups, sauces, condiments and stocks.
Patent EP-0033001-A2 (EP)
Inventor: GRUBER WERNER DR
IPC: C08F220/12
Filed: 1980-12-13
Abstract: The present invention is directed to anaerobically hardening adhesives, sealing compounds, and the like. More particularly, the present invention is directed to an anaerobically hardening adhesive and sealing composition comprising methacrylic or acrylic acid esters, organic peroxides, nitrogen containing compounds as accelerators for polymerization, and customary adjuvant substances, wherein a content of cyanoacetic acid or an ester or an amide thereof is also present.
Patent EP-0031946-A2 (EP)
Inventor: MUELLER DALE A
IPC: F24F11/02
Filed: 1980-12-23
Abstract: A system for controlling defrosting of the outdoor coil of a reverse cycle refrigeration apparatus or heat pump comprises a controller (50) receiving input signals indicative of the temperature of the outdoor coil (12) and the operation of the compressor (14). The controller (50) has a timing function which is initiated upon the outdoor coil temperature being at or below a preselected value (T2) and the compressor (14) being operated. The duration of the timing function being determined on a substantially continuous basis as a function of the magnitude of the outdoor coil temperature. The controller (50) has an operative connection to the apparatus (18, 16) so as to, upon completion of the timing function, place the reverse cycle refrigeration apparatus into an outdoor coil defrost mode of operation (Fig. 1)
Patent EP-0015755-A2 (EP)
Inventor: BOGOCH SAMUEL DR
IPC: A61K49/00
Filed: 1980-03-06
Abstract: Disclosed herein are novel compounds Recognins termed Recognin M and Recognin L, belonging to a group of compounds termed Recognins, and produced, respectively, from artificial mammary and lymphoma cancer cells. Recognin M and Recognin L are useful for therapeutic and diagnostic purposes. They are each characterized by forming a single line precipitate with a specific antibody In quantitative precipitation tests and Ouchterlony gel diffusion tests; by being soluble in water and aqueous solutions having an acid or neutral pH, and Insoluble at an alkaline pH; having a spectrophotometric absorption peak wave-length of 280 mµ; and having a molecular weight of about 8,000 (as determined by thin layer gel chromatography). Recognin M contains approximately 90 and Recognin L approximately 92 aminoacid residues.
Patent EP-0036477-A2 (EP)
Inventor: KELL GERHARD ROBERT
IPC: H01R13/11
Filed: 1981-01-30
Abstract: Electrical contact element (1) which is to be used with or without an insulating housing (6) and is self-locking in connection with a contact pin (4). The plug region (1b) is designed such that side parts (3a, 3b) connect to a flat-bulged centre part (2), of which side parts side part (3a) merges into the base part (1c) of the crimp region (1a) and side part (3b) stands free of the centre part (2). Centre part (2) has a latching tongue (2a) pointing towards the plug region (1b), which latching tongue (2a) fixes the connection in a locked manner in the opening (4a), after plugging onto the contact pin (4). Side parts (3a, 3b) have cut-outs for contact pins (4) which can be cross-shaped (3c) or round or oval (3d). Contact elements (1) can be plugged, offset with respect to one another, directly onto a contact pin (4) or to the housing (6) with contact pin (4), the plug connection to the housing (6) being unlockable by pulling on the housing (6) against the direction of plug insertion (E). By means of a folded-type design of the housing sidewalls (K1, K2), the height of the housing (6) can be kept low and the latching dogs (7) required for fixing the element (1) are injection moulded directly onto the inner longitudinal side (J) of the housing, since a folded-type design provides the opening size necessary for insertion of the elements (1). <IMAGE>
Patent EP-0035708-A2 (EP)
Inventor: BONSE GERHARD DR
IPC: A01N43/64
Filed: 1981-02-26
Abstract: In the preparation of 4-amino-6-tert.-butyl-3-alkylthio-1,2,4-triazin-5-(4H)-one of the formula   <IMAGE>   wherein (1) pivaloyl cyanide of the formula (CH3)3C-CO-CN is reacted to form a derivative of pyruvic acid, (2) the pyruvic acid derivative is condensed with thiocarbohydrazide of the formula NH2-NH-CS-NH-NH2 to form 4-amino-6-tert.-butyl-3-mercapto-1,2,4-triazin-5(4H)-one of the formula   <IMAGE>  and (3) this is alkylated, the improvement which comprises effecting step (1) by reaction with a carboxylic acid anhydride of the formula R-CO-O-CO-R in which R is an optionally substituted aliphatic radical with up to 8 carbon atoms or an optionally substituted phenyl radical, in the presence of a strong acid at a temperature between about -50 DEG  and +150 DEG  C., and then adding water to the reaction mixture, thereby to form trimethylpyruvic acid N-acylamide of the formula (CH3)3C-CO-CO-NH-CO-R.
Patent EP-0043029-A2 (EP)
Inventor: HETHERINGTON RICHARD J
IPC: H05K1/02
Filed: 1981-06-16
Abstract: The MLC substrate (10) is formed of a plurality of ceramic green sheets that are provided with metallurgy patterns and/or metal filled vias laminated together and sintered. The top sheet (40) thickness is at least 20 % greater than the individual thickness of the underlying sheets (21,23, 25). At least part of the vias (30,34) in said top sheet (40) form a pattern of vias (30) having a center-to-center spacing of 178 to 305 um, with the via diameter being in the range of 35 to 55 % of the center-center via spacing. The MLC substrate (10) in which cracks especially between closely spaced metal filled vias (30) are minimized or eliminated can be used to interconnect LSI circuit chips mounted on top of it.
Patent EP-0053746-A2 (EP)
Inventor: DREFAHL JENS
IPC: F24J2/04
Filed: 1981-11-21
Abstract: In this process and installation, for buildings having flat or sloping roofs which are covered with a soil layer that can be moistened, and preferably planted, above a roof skin, the said layer is used as a heat-conducting heat absorber or heat store for primary energy reaching the roof from outside and/or for recovery energy flowing from the building, in order to heat and/or cool the building. To this end, a heat-abstracting means (20) through which fluid expediently flows, such as a pipe coil system or a plate system supporting the soil layer, is situated in or under the soil layer (18). This system can be used, by appropriate shaping of the top, simultaneously as an obstacle to slippage of the soil layer in the case of sloping roofs and, in particular in the case of flat roofs, as a means for improving the angle of incidence of solar radiation. The heat is preferably removed from the soil layer by means of a heat pump system and of an intermediate heat store, this removal being controlled or regulated as a function of demand.****** <IMAGE>
Patent EP-0043702-A2 (EP)
Inventor: HIRAGA MASAHARU
IPC: F04C18/02
Filed: 1981-07-01
Abstract: A scroll type fluid displacement apparatus is disclosed. The apparatus includes a housing. A fixed scroll member is fixedly disposed within the housing and comprises a first end plate means from which a first wrap means extends. An orbiting scroll member comprises a second end plate means from which a second wrap means extends, and is supported for orbiting motion within the housing. Both wrap means interfit at an angular and radial offset to make a plurality of line contacts to define at least one pair of symmetrically disposed, sealed off fluid pockets. The first end plate means is formed with two holes which are placed at symmetrical positions to be simultaneously closed by the axial end surface of the second wrap means. These two holes are connected to one another by a passage means. The pressure in the sealed off fluid pockets is thereby equalized at the time the pockets are sealed.
Patent EP-0056962-A2 (EP)
Inventor: FISCHER HERBERT DR
IPC: A61K31/41
Filed: 1982-01-16
Abstract: N-substituted polyglycidyl urazole compounds of the general formula <IMAGE>  (I)  in which the radicals R represent a glycidyl radical corresponding to the following general formula    <IMAGE> (II) wherein R1 represents hydrogen or an alkyl radical containing from 1 to 4 carbon atoms, or two of the radicals R represent a glycidyl radical of general formula II while the remaining radical R is a radical Z, other than said glycidyl radical, containing carbon, hydrogen and, optionally, heteroatoms, are useful in the treatment of various forms of leukemia.
Patent EP-0062194-A2 (EP)
Inventor: WAGNER PAUL-HEINZ
IPC: B25B21/00
Filed: 1982-03-19
Abstract: 1. Power-driven screw-driving tool comprising 1.1 a wrench head casing (10) including a rotatable ring inset (11) to mount a button die, 1.2 a driving means (28, 29) engaging the wrench head casing (10) to move relative to the wrench head casing (10) a support element (27) capable to be applied to a fixed abutment (20), and 1.3 a rotation lock retaining the ring inset (11) in the wrench head casing (10) during the tensioning movement of the driving means (28, 29), characterized in that 1.4 the rotation lock consists of a self-locking gear engaging a tothing (14) of the ring inset (11) and comprising a rotatable drive shaft (17).
Patent EP-0069841-A2 (EP)
Inventor: HEINEMANN OTTO ING GRAD
IPC: B65G65/06
Filed: 1982-05-07
Abstract: The invention relates to an apparatus for reclaiming a bulk material mixing bed (1), having a preferably triangular or trapezoidal cutting face (7). In this regard, an extension arm (3) is mounted on a movable bridge (2), which arm carries a rake (8) for scraping the mixing bed cutting face (7). In order to achieve a relatively simple yet very stable construction and reliable reclamation, a rotary rail (9), which can be rotated by means of a drive (10), is mounted on the extension arm (3) in the region of the centre of the cutting face (7), by which rail the rake (8) extending to the corners of the cutting face (7) is carried longitudinally displaceably (arrow 13). <IMAGE>
Patent EP-0071719-A2 (EP)
Inventor: CHRISTIAN JOHN HUNT
IPC: G06F12/08
Filed: 1982-06-15
Abstract: in a paging storage subsystem, a plurality of addressable data storage devices (16-18) are selectively directly accessed using direct addresses (21, 26) or accessed via a cache memory (100), using one of a plurality of logical addresses (23, 25), each of the data storage devices being represented by a plurylity of the logical addresses. Each of the data storage devices can be reserved for direct access; such reservation does not apply to device accesses via the cache. Accesses to the devices are queued on a logical device basis, preferably separately for read and write accesses. Multiple ports (20, 15) from host to subsystem can be employed concurrently.
Patent EP-0079583-A2 (EP)
Inventor: SILVERMAN ROBERT ANDREW
IPC: G03C1/485
Filed: 1982-11-11
Abstract: A radiation-sensitive emulsion particularly adapted to forming a direct-positive image, comprised of a dispersing medium and silver halide grains, and a direct-positive photographic element containing the same are disclosed. The emulsion is characterized by
 a first, core-shell silver halide grain population having a coefficient of variation of less than 20%, and
 a second silver halide grain population capable of internally trapping photolytically generated electrons and incapable of forming a surface latent image within the direct-positive exposure latitude of the first grain population,
 said second grain population have an average diameter less than 70% that of said first grain population, and
 said first and second silver halide grain populations being present in a weight ratio range of from 5:1 to 1:5.
Patent EP-0068610-A2 (EP)
Title: A power spinner for rotating a Kelly joint
Inventor: TRUE MARTIN EARL
IPC: E21B3/04
Filed: 1982-05-11
Abstract: An improved power spinner (10) for rotating a kelly joint has a pipe sub (12) rotatably mounted in a housing (18) with a ring gear (20) on the sub and a motor mounted on the housing for powering the ring gear. A drive gear (30) is connected coaxially to the motor and a shifting arm (32) is pivotally mounted coaxially with the axis of the drive gear (30). A movable gear (34) is positioned in the plane of the ring gear (20) and is mounted on the shifting arm (32) for engagement and disengagement with the ring gear; the movable gear (34) is drivingly coupled to the drive gear (30) by an Intermediate gear (36). An actuator (50) is connected to the shifting arm (32) for laterally moving the movable gear (34) toward and away from the ring gear (20) through the action of a cam (44) which includes a section (45) for locking the gears (34) and (20) together when engaged.