baber/WOPTO huggingface dataset:
Patent FI-895520-A0 (FI)
Inventor: JACKSON WILLIAM PAUL
IPC: C07C275/30
Filed: 1989-11-20
Abstract: The present invention is concerned with the compound of formula (I)and salts, solvates and physiologically functional derivatives thereof, processes for the preparation of this compound, pharmaceutical formulations containing it and their use in medicine.
Patent FI-900469-A0 (FI)
Inventor: WENZEL UDO
IPC: A61K9/00
Filed: 1990-01-30
Abstract: The invention relates to a system for preferably peroral administration with erosion-controlled active agent release and a process for its preparation from which preferably low solubility active agents are released with delay, and in a possible combination of suitable, high solubility active agents the latter are released rapidly and with only slight delay. The active agent(s) is (are) fabricated in the usual manner with adjuvants capable of swelling, e.g. microcrystalline cellulose or starch, with adjuvants which have higher affinity to water and function as swelling controllers (e.g. polyethylene glycols, strongly hydrating inorganic compounds) and optionally with additional adjuvants. The pharmaceutical preparations prepared in this manner contribute significantly to improving the therapy of various illnesses, for when suitable and preferably low solubility active agents are incorporated, the adjustment and maintenance of therapeutically effective concentrations of active agent are ensured.
Patent FI-900600-A0 (FI)
Inventor: CHANCE RONALD EUGENE
IPC: C07K/
Filed: 1990-02-07
Abstract: Analogs of human insulin modified at position 29 of the B chain thereof and, optionally, at other positions, have modified physico-chemical and pharmacokinetic properties and are useful in the treatment of hyperglycemia. The insulin analogs are of the formula <IMAGE> or a pharmaceutically acceptable salt thereof, wherein A21 is alanine, asparagine, aspartic acid, glutamine, glutamic acid, glycine, threonine, or serine; B1 is phenylalanine, aspartic acid, or is absent; B2 is valine or may be absent when B1 is absent; B3 is asparagine or aspartic acid; B9 is serine or aspartic acid; B10 is histidine or aspartic acid; B27 is threonine or is absent; B28 is any amino acid, B29 is L-proline, D-proline, D-hydroxyproline, L-hydroxyproline, L-(N-methyllysine), D-lysine, L-(N-methylarginine) or D-arginine; B30 is alanine, threonine or is absent; Z is -OH, -NH2, -OCH3, or -OCH2CH3; X is Arg, Arg-Arg, Lys, Lys-Lys, Arg-Lys, Lys-Arg, or is absent; and Y may be present only when X is present and, if present, is Glu or an amino acid sequence which comprises all or a portion of the sequence <IMAGE>  and which begins at the N-terminus Glu of such sequence; provided that when A21 is asparagine, B1 is phenylalanine, B2 is valine, B3 is asparagine, B9 is serine, B10 is histidine, B27 is threonine, B28 is lysine, B29 is L-proline, B30 is threonine, X is absent and Y is absent, then Z is -NH2, -OCH3 or -OCH2CH3.
Patent FI-904915-A0 (FI)
Inventor: MEGURO KANJI
IPC: C07C275/28
Filed: 1990-10-05
Abstract: A quinoline derivative of the formula (I): <CHEM> wherein each phenyl ring of A, B and C can have one or more substituents, <CHEM>  (R<1> is a hydrogen atom or a lower alkyl group) or <CHEM> (R<2> is a lower alkyl group or a lower alkoxy group), and n is 0 or 1, or its salt, which possesses an inhibitory action against acyl-CoA: cholesterol acyltransferase.
Patent FI-905705-A0 (FI)
Inventor: HUETTLIN HERBERT
IPC: B01J2/16
Filed: 1990-11-19
Abstract: In a process chamber (12) having a gas inlet (16) and a gas outlet (18) for generating a generally upward-directed gas stream (E), a hollow lance (40) extends transversely to the general gas stream (E) between two pairs of baffles (42, 44). The lance (40) has a profile, which is symmetrical to a vertical centre plane (A), and contains a conveying channel (60) which extends in the longitudinal direction of said lance and to which material discharge nozzles (80) are connected. Above the baffles (42, 44), a pair of half-shells (52) is located which, together with the baffles (42, 44), form a straight trough (53) which is at least approximately symmetrical relative to the centre plane (A). Between the gas inlet (16) and gas outlet (18), a pressure gradient can be established, which creates a straight-line fluidised bed (F) within the trough (53). 
<IMAGE>
Patent FI-911146-A0 (FI)
Inventor: ZERTANI RUDOLF
IPC: G03F7/032
Filed: 1991-03-07
Abstract: Photopolymerisable mixt. based on a polymeric binder (I), a cpd. (II) with polymerisable gp(s), capable of free radical polymerisation and a photo-reducible dyestuff (III) also contains a dicyclopentadienyl-bis- 2,4,6-tri-fluorophenyl-Ti or Zr cpd. (IV). Pref. (I) is insol. in H2O and soluble in aq. alkaline solns. (II) is an (alk)acrylate ester with gp(s). capable of photo-oxidn. when exposed in the presence of (III), and is pref. an amino, urea, thio or enol gp. (III) is a xanthene, thiazine, pyronine, porphyrin or acridine dyestuff. In (IC), at least one of the cyclopentadienyl gps. is substd. The mixt. may also contain a trihalomethyl cpd. (V) decomposed by radiation, (pref. an s-triazine cpd. with trihalomethyl gp(s). and opt. another substit.; or an aryl trihalomethyl sulphone). An acridine, phenazine or quinoxaline cpd. may be added as photoinitiator. The mixt. contains 20-90 (wt.)% 10-80% (II) and 0.05-20% initiators activated by radiation, w.r.t. non-volatiles. The recording material has a base coated with the mixt. and pref. also another transparent layer with low permeability for atmos. O2, whichis soluble in the developer liquid for the photopolymerisable layer.
Patent FI-913611-A0 (FI)
Inventor: MOELDERS HORST
IPC: C12Q1/6897
Filed: 1991-07-29
Abstract: Process in which microorganisms equiped with a plasmid vector, pGL4, constructed by molecular biological techniques, can be used as biosensors for mercury compounds. A gene complex ($i(mer-Operon)) inductible by mercury ions is combined by molecular cloning with the luciferase (LUX) gene system of $i(Vibrio Harveyi). The arrangement of the two gene units is designed so that the $i(mer-Operon) promoter, which is positively regulated by mercury compounds, also controls the transcription of the LUX genes. As a result, microorganisms transformed with plasmid pGL4 respond to increasing quantities of mercury cations in the surrounding medium with an increase in their emitted bioluminescence. The process is absolutely specific for mercury, rapid and highly sensitive: the proven limit for mercury ions is approximately 0.2 ppb, i.e., 5 times lower than the detection threshold for the most powerful established methods (atomic absorption spectrometry), which detect 1 to 5 ppb of mercury and require a considerable quantity of apparatus. A further advantage of the invention is the possibility of determining measurement values (bioluminescence signals emitted by microorganisms transformed by plasmid pGL4) without direct contact between the biosensor and the signal-amplification unit (bioluminescence apparatus). The method therefore permits simple, continuous, on-line determination of critical mercury concentrations.
Patent FI-913671-A0 (FI)
Inventor: DARSY ERIC
IPC: B23P19/02
Filed: 1991-08-01
Abstract: The invention relates to a method for production of castings of aluminium or its alloys comprising integrated runners intended for the distribution of a lubricant or for the circulation of a heat-exchange fluid. 
<??>The method is characterised in that: 
 
  - one or more previously shaped tubes of aluminium or aluminium alloys are placed in a mould, the ends of the tube or tubes being outside the mould or the cores inserted therein; 
  - the alloy is poured into the cavity of the mould; 
  - after removal from the mould, the excess parts of the tube or tubes are removed. 
 
<??>This method applies to the mass-production of castings having a system of internal runners, such as cylinder heads, compressor cylinders, lubrication systems, convectors, etc. 
<IMAGE>
Patent FI-913757-A0 (FI)
Inventor: BENKER WERNER
IPC: C04B41/88
Filed: 1991-08-07
Abstract: For the production of mouldings of silicon-infiltrated silicon carbide, in particular of pipes, a mixture of silicon carbide powder, organic binder and optionally carbon is moulded to give a cylindrical elongated green compact, the binder of the green compact is removed in a nonoxidising atmosphere by carbonisation at about 1000 DEG C and the porous blank obtained is siliconised by the action of liquid silicon at temperatures of at least 1400 DEG C. During the siliconisation, the blank rests on a porous SiSiC support which is in contact with liquid silicon. The SiSiC support has a straight channel with an angular cross-section and recesses in which the cylindrical blank to be siliconised is placed, and the SiSiC support has downward-projecting side walls whose lower surface is in contact with the liquid silicon. <IMAGE>
Patent FI-914620-A0 (FI)
Inventor: PITHA JOSEF
IPC: C08B37/16
Filed: 1991-10-02
Abstract: A process for preparing regiospecifically hydroxyalkylated  alpha -, beta - or  gamma -cyclodextrins wherein the substitution is either directed toward hydroxyls 2 or 2,3 of the glucose units with little substitution on hydroxyl 6 or toward hydroxyls 6 and with little substitution on the secondary hydroxyls. The regiospecificity is obtained through the proper control of basicity of the reaction mixtures which are comprised of epoxide and cyclodextrins and a suitable solvent.
Patent FI-914898-A0 (FI)
Inventor: KATSOYANNIS PANAYOTIS G
IPC: A61P3/08
Filed: 1991-10-17
Abstract: New insulin analogues have now been synthesized and found to be hepatospecific. These insulin analogues contain substitutions for one or more amino acids in the A and B chains. Specifically, tryptophan or other bulky, hydrophobic residues are substituted at the A13, A14, A15, A19 and B16 positions of the insulin polypeptide to produce the hepatospecific insulin analogues of the claimed invention.
Patent FI-915169-A0 (FI)
Inventor: DUNCANSON ROBERT JOHN
IPC: B27M1/00
Filed: 1991-11-01
Abstract: PCT No. PCT/AU90/00171 Sec. 371 Date Oct. 24, 1991 Sec. 102(e) Date Oct. 24, 1991 PCT Filed May 2, 1990 PCT Pub. No. WO90/13402 PCT Pub. Date Nov. 15, 1990.An improved panel jointing system wherein panels (10,11) are provided with profiled edge portions comprising tongue formations (12) and recesses (13) which are of complementary shape to the tongues (12), the tongues (12) of one panel being receivable in the recesses (13) of another panel, wherein the profiled edge portions comprise integrally formed projections (15, 16) projecting from the edge surfaces of the tongues (12) and/or from the walls forming the recesses (13), the tongues (12), recesses (13) and projections (15, 16) being shaped and dimensioned so that when the tongues are received in the recesses, the tongues (12) form a friction fit with the recesses (13), and the opposed facing surfaces of the tongues (12) and the walls of the recesses (13) being spaced apart so as to form a gap (18) of approximately uniform width which extends along the joint between the panels, interrupted by the projections (15, 16), the gap being fillable with adhesive.
Patent FI-915188-A0 (FI)
Inventor: GALVIN PAUL HENRI
IPC: C21C1/02
Filed: 1991-11-04
Abstract: Product for desulphurising cast irons into liquid steels, based on magnesium particles coated with the aid of an organic product based on saturated aliphatic acid or their solid esters and a refractory powder.
Patent FI-923530-A0 (FI)
Inventor: NESTY PATRICK
IPC: C01B11/06
Filed: 1992-08-05
Abstract: The invention relates to a process for the preparation of concentrated alkali metal hypochlorite solutions in which chlorine and the alkali metal hydroxide are injected into a vertical receptacle, the bottom part of which has a cross-section less than the cross-section of its top part. This receptacle is equipped with an external hypochlorite recycling loop.
Patent FI-933194-A0 (FI)
Inventor: KLEINE WERNER
IPC: B23B31/02
Filed: 1993-07-14
Abstract: The shank (9) of the drill or chisel has two diametrically opposite driving slots (10) with an open end and two diametrically opposite locking slots (11) with both ends closed. To raise the level of torque that can be transmitted to the tool, there are also two diametrically opposite extension slots (12) which lie within the cross-section of the locking slots and extend beyond them. The extension slots are open at the free end of the shank and are engaged by driving keys in the spindle socket. The extension slots are offset by an angle (a) from the axis of symmetry of the locking slots, and the driving flank (12a) is straight and tangential to the curved floor of the locking slot.
Patent FI-952178-A0 (FI)
Inventor: KITTLE KEVIN JEFFREY
IPC: C09D5/46
Filed: 1995-05-05
Abstract: PCT No. PCT/GB93/02288 Sec. 371 Date Jun. 12, 1995 Sec. 102(e) Date Jun. 12, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/11446 PCT Pub. Date May 26, 1994A power coating composition comprises at least one film-forming polymeric material and has dry-blended therewith two or more dry-blended additives selected from solid, particulate, inorganic, water-insoluble materials which may be ceramic or mineral materials and/or may be oxides, mixed oxides, hydrated oxides, hydroxides, oxide-hydroxides or oxysalts of metals and metalloids, at least 95% by volume of the powder coating composition having a particle size not exceeding 50 microns.
Patent FI-954068-A0 (FI)
Inventor: KJELL DOUGLAS PATTON
IPC: C07C217/54
Filed: 1995-08-30
Abstract: The present invention provides a novel process for preparing a compound of formula I <CHEM>  wherein     R is C1-C4 alkyl; R<1> and R<2> each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidino, dimethylpyrrolidino, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; and     n is 2 or 3;  or a pharmaceutically acceptable salt thereof, comprising   a) condensing (C1-C4 alkyl) 4-hydroxybenzoate with ethylene carbonate or propylene carbonate in the presence of a condensation catalyst and a moderately polar, water immiscible solvent having a high boiling point;   b) reacting the product of step a), a compound of formula III <CHEM>  wherein     R and n are as defined above, with a leaving group donor; and   c) reacting the product of step b), a compound of formula IV <CHEM>  wherein     R and n are as defined above and X is a leaving group, with a base selected from the group consisting of piperidine, pyrrolidine, methylpyrrolidine, dimethylpyrrolidine, morpholine, dimethylamine, diethylamine, and 1-hexamethyleneimine.   The product of the above process, a compound of formula I, also is novel and is useful for the preparation of pharmaceutically active compounds of formula II, particularly via the following novel process   <CHEM>  wherein     R is C1-C4 alkyl; R<1> and R<2> each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidino, dimethylpyrrolidino, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; and     n is 2 or 3;  or a pharmaceutically acceptable salt thereof, comprising   a) condensing (C1-C4 alkyl) 4-hydroxybenzoate with ethylene carbonate or propylene carbonate in the presence of a condensation catalyst and a moderately polar, water immiscible solvent having a high boiling point;   b) reacting the product of step a), a compound of formula III <CHEM>  wherein     R and n are as defined above, with a leaving group donor;   c) reacting the product of step b), a compound of formula IV <CHEM>  wherein     R and n are as defined above; and X is a leaving group, with a base selected from the group consisting of piperidine, pyrrolidine, methylpyrrolidine, dimethylpyrrolidine, morpholine, dimethylamine, diethylamine, and 1-hexamethyleneimine;   d) reacting the product of step c) with a compound of formula IV <MATH> wherein R<3> and R<4> are as defined above, or a pharmaceutically acceptable salt thereof;   e) optionally removing the reaction product from step d) ; and f) optionally forming a salt of the reaction product from either step d) or step e).
Patent FI-964957-A0 (FI)
Inventor: MATSUMURA SYUNJI
IPC: A01K31/04
Filed: 1996-12-11
Abstract: PCT No. PCT/IB95/00451 Sec. 371 Date Dec. 11, 1996 Sec. 102(e) Date Dec. 11, 1996 PCT Filed Jun. 8, 1995 PCT Pub. No. WO95/34198 PCT Pub. Date Dec. 21, 1995Spraying tubes (20 . . . ) through each of which a plurality of spraying holes are perforated along the longitudinal axis of each tube are placed in prescribed positions upper than feces boards (10 . . . ) of henhouses; and the spraying tubes (20 . . . ) are connected to agent-supplying means for supplying an agent such as a tank, a pump, etc. and airsupplying means for supplying compressed air such as a compressor, etc. The spraying holes make an angle not smaller than 5 degrees and not greater than 90 degrees as measured downward from the horizontal plane at the time of spraying an agent, in order to make it possible to spray the agent to feces boards (10 . . . ) and feces floor (12). The eggs of pests such as housefly and the like laid on the feces adhering to the feces boards and feces floor can efficiently and certainly be controlled. Since compressed air is supplied to the spraying tubes, no residual agent remains in the spraying tubes and the agent can be used up effectively, and at the same time the spraying tubes can be prevented from, the clogging caused by the agent.
Patent FI-990871-A0 (FI)
Inventor: VIRTANEN JARI
IPC: B23D45/12
Filed: 1999-04-19
Abstract: The invention relates to a system for presetting the cutting tools of a cut-off machine for a pipe or a shaft. A cutting tool cassette (1) associated with a rotatable cutting head (11) is removed from the cutting head and mounted and aligned on a separate presetting frame (12), which is provided with fixing and centering means (13) for a pipe or a shaft (14), and with a reference surface (15) which has a predetermined position relative to the position of a tool (8, 9) present in the cutting head (11) and operating a cutting wheel (4). The cassette (1) placed on the presetting frame (12) has its adjusting device (5, 6) adjusted by means of the reference surface in such a way that the cutting wheel (4) is set at a desired initial machining distance from the surface of the pipe or shaft (14). <IMAGE>
Patent AP-9901490-A0 (AP)
Title: Pump.
Inventor: KOCSIS FERENC
IPC: E21B43/12
Filed: 1997-08-26
Abstract: A pump (1)for delivering liquid from a liquid source, such as water from a bore or well. The liquid enters a pump chamber (3)via a first valve (5). The pump chamber (3)is in fluid communication with an air pipe (4)and a delivery pipe (2). A first air flow control mechanism (6)controls air flow through the air pipe (4). In a first stage of the pumping cycle, the first air flow control mechanism (6)directs air via the air pipe (4)to the pump chamber (3)so that liquid is pushed into and up the delivery pipe (2). In a second stage of the pumping cycle, the first air flow control mechanism (6)vents air from the pump chamber (3)via the air pipe (4). A second air flow control mechanism (19)may be provided so that air may be supplied to the delivery pipe (2)in the second stage of the pumping cycle to assist in the carriage of liquid in the delivery pipe (2).
Patent IL-82395-A0 (IL)
Title: Process for preparation of quinolinecarboxylic acid derivatives
IPC: A61P31/04
Filed: 1987-04-30
Abstract: Quinolinecarboxylic acid derivatives represented by the following general formula (I) and physiologically-acceptable salts thereof. <CHEM> wherein R<1> is hydrogen, alkyl, or substituted or unsubstituted phenyl; R<2> is hydrogen, alkyl, aikoxy, hydroxy, halogen, nitro or substituted or unsubstituted amino; R<3> is hydrogen or optionally-substituted alkyl; R<4> and R<5> are same or different and are alkyl or hydroxyalkyl or R<4> and R<5> may be combined and may form a cyclic amino together with the adjacent nitrogen atom and said cyclic amino may also be substituted and may further contain nitrogen, oxygen or sulfur as hetero-atoms therein; and X is halogen. have been found to be very effective antibacterial therapeutic agents for systemic and local infectious diseases caused by P. aeruginosa and Grampositive and negative bacteria.
Patent IL-86500-A0 (IL)
Title: Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase
IPC: C12N9/10
Filed: 1988-05-25
Abstract: Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate (EPSP) synthases, DNA encoding glyphosate-tolerant EPSP synthases, plant genes encoding the glyphosate-tolerant enzymes, plant transformation vectors containing the genes, transformed plant cells and differentiated transformed plants containing the plant genes are disclosed. The glyphosate-tolerant EPSP synthases are prepared by substituting an alanine residue for a glycine residue in a conserved sequence found between positions 80 and 120 in the mature wild-type EPSP synthase.
Patent IL-96995-A0 (IL)
Title: Pharmaceutical compositions containing pimobendan and their preparation
IPC: A61K47/12
Filed: 1991-01-22
Abstract: Pimobendan dosage forms for oral administration contain citric acid, ensuring constantly good absorption even with large pH variations in the gastrointestinal tract.
Patent IL-97645-A0 (IL)
Title: Production of enzymes in seeds and their use
IPC: C12N9/00
Filed: 1991-03-22
Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the method provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.
Patent AU-PP660798-A0 (AU)
Title: Method for measuring cellular adhesion
IPC: G01N33/49
Filed: 1998-10-20
Abstract: A diagnostic method for determining the binding capacity of cells such as platelets or progenitors thereof in a biological sample comprises passing the biological sample over an adhesive substrate immobilised on a solid support under defined flow conditions and for a time sufficient to enable cells from the biological sample to bind to the adhesive substrate, and subsequently detecting cells bound to the adhesive substrate. The method may be used for detection in an individual of the presence of or risk of developing a condition or disorder involving cellular, particularly platelet, abnormalities.
Patent AU-PP712998-A0 (AU)
Title: Noise attenuation device
IPC: G10K11/172
Filed: 1998-11-16
Abstract: A noise attenuation device having an array of quarter wave resonators which have varying mouth widths disposed adjacent an aperture or ventilation opening having a predefined width. The resonators are tuned to a resonant frequency, increasing from one face of the attenuation device to another, and so that the mouth widths are each greater than the width of the aperture or ventilation opening, respectively. Optionally, a second array tuned to a different frequency may be disposed on the opposite side of the aperture and the aperture may be kinked so that there is no direct line of sight through the device.
Patent FI-20055569-A0 (FI)
Inventor: SIITONEN PEKKA
IPC: B02C17/22
Filed: 2005-10-24
Abstract: A lifting element for a drum of a grinding mill to be used for grinding of ores and minerals. The lifting element is attachable to a frame of the drum and extending in the longitudinal direction of the drum. The lifting element includes a flexible body and a wear protection element located in the leading edge of the body with respect to the direction of rotation of the drum. The wear protection element includes at least two different parts manufactured of different materials having toughness and hardness different from each other.