baber/WOPTO huggingface dataset:
Patent WO-2020181180-A1 (WO)
Title: A:t to c:g base editors and uses thereof
Inventor: LIU DAVID
IPC: C12N9/02
Filed: 2020-03-06
Abstract: The instant specification provides for base editors which satisfy a need in the art for installation of targeted transversions of adenine (A) to cytosine (C), or correspondingly, trans versions of thymine (T) to guanine (G). The base editor domains include a nucleic acid programmable DNA binding protein and an adenine oxidase. The base editors may be engineered through the use of continuous or non-continuous evolution systems, such as phage-assisted continuous evolution (PACE). In particular, the instant specification provides for adenine-to-cytosine (or thymine-to-guanine) base editor variants that overcome deficiencies in the art for base editors that can install single-base transversion mutations. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, pharmaceutical compositions comprising, and vectors and kits for the generation of, targeted base editors are provided. In some embodiments, cells containing such vectors are provided. In some embodiments, methods of treatment comprising administering the base editors are provided.
Patent WO-2020185568-A1 (WO)
Inventor: WENTZ CHRISTIAN
IPC: H04L9/32
Filed: 2020-03-06
Abstract: A method performing anonymous hardware attestation. A local software monitor is loaded at an originating device. The local software monitor may receive at least a command to execute at least a program and execute the at least a program by performing a series of authentications. Originating device activates a secure computing module located within originating device to generate a secure proof a device specific secret of the originating device. The originating device generates a digital signature conferring a credential on the local software module. The originating device deactivates the secure computing module upon generating the digital signature.
Patent WO-2020181202-A1 (WO)
Title: A:t to t:a base editing through adenine deamination and oxidation
Inventor: LIU DAVID
IPC: C12N9/78
Filed: 2020-03-06
Abstract: The present disclosure provides for base editors which satisfy a need in the art for installation of targeted transversions of thymine (T) to adenine (A), or correspondingly, transversions of adenine (A) to thymine (T). The base editor domains include a nucleic acid programmable DNA binding protein and one or more of an adenosine deaminase or an oxidase domain. The base editors may be engineered through the use of continuous or non-continuous evolution systems, such as phage-assisted continuous evolution (PACE). In particular, the present disclosure provides for adenine-to-thymine (or thymine-to-adenine) base editor variants which satisfy deficiencies of those in art for single-base A:T to T:A transversion mutations. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, pharmaceutical compositions comprising, and vectors and kits for the generation of, targeted base editors are provided. In some embodiments, cells containing such vectors are provided. In some embodiments, methods of treatment comprising administering the base editors are provided.
Patent WO-2020181241-A1 (WO)
Title: Récipient à fermeture magnétique
Inventor: ROGERS KYLE EDWARD
IPC: A45C13/00
Filed: 2020-03-06
Abstract: L'invention concerne un dispositif de type récipient qui a une enveloppe externe avec une ouverture qui est fermée par un mécanisme de fermeture. Le mécanisme de fermeture peut comprendre des bandes magnétiques qui sont configurées pour fermer partiellement ou totalement l'ouverture.
Patent WO-2021183109-A1 (WO)
Title: Mount for interchangeably receiving various expandable accessories attached to a portable electronic device
Inventor: CHEN IVAN
IPC: F16M13/04
Filed: 2020-03-10
Abstract: A mount configured to removably and interchangeably receive a plurality of different expandable accessories attached to a portable electronic device. The mount includes an attachment mechanism, a receiving member, and a connecting member having a first end coupled to the attachment mechanism and a second end coupled to the receiving member. The receiving member includes a plurality of legs that are adapted to removably receive a first expandable accessory of the plurality of different expandable accessories and to interchangeably and removably receive a second expandable accessory of the plurality of different expandable accessories, where the second expandable accessory is different from the first expandable accessory.
Patent WO-2020205606-A1 (WO)
Title: Microwave imaging using a radially-polarized probe
Inventor: DVORSKY MATTHEW
IPC: G01S13/02
Filed: 2020-03-27
Abstract: A microwave and millimeter wave imaging system. In either a far-field or a near-field detection mode, a radially-polarized probe transmits an imaging signal along a predetermined scan path to detect a target in a sample. The imaging signal's orientation is independent of the target's orientation and changes at each target as the probe transmits the signal during scanning. A measurement system receives scattered waves reflected from the sample via a single channel and images the sample and the target based on the reflected waves independent of the orientation of the target.
Patent WO-2020219758-A1 (WO)
Title: Gas sensors with negligible response to humidity and temperature
Inventor: GUPTA NIHARIKA
IPC: G01N33/00
Filed: 2020-04-23
Abstract: In one example, a gas sensor is provided. The gas sensor includes a substrate, an isolation region formed on outer edges of the substrate, a micro-heater formed on the isolation region, a sensing layer formed on the substrate inside of the isolation region, and a source and drain formed around the sensing layer and inside of the isolation region.
Patent WO-2021029923-A1 (WO)
Inventor: FLASTER MICHAEL LEONARD
IPC: H04W84/18
Filed: 2020-04-28
Abstract: An emergency controller for an integrated, portable, battery-powered, power emergency station including one or more rechargeable batteries; one or more AC outlets powered by the rechargeable batteries to provide emergency back-up power during power outage; one of one or more wired sensors and one or more wireless sensors that provide at least one of real-time heat, smoke, barometric, wind speed, humidity, distance, or seismic data, comprising at least one hardware processor; and one or more software modules that, when executed by the at least one hardware processor, detects a power outage to a house or building; activates the one or more rechargeable batteries to provide at least one of signaling and emergency back-up power to at least one of: one or more of pumps, one or more lights, one or more alarms, an automatic transfer switch, one or more medical devices, and one or more heaters.
Patent WO-2020231631-A1 (WO)
Title: Stimulation de grès à l'aide d'une génération in situ d'acide à boue
Inventor: AL-NAKHLI AYMAN R
IPC: E21B43/27
Filed: 2020-04-29
Abstract: L'invention concerne un procédé de stimulation de la production d'hydrocarbures à partir d'une formation de grès comprend les étapes consistant à injecter un fluide de stimulation formé à partir d'un précurseur générant de l'acide fluorhydrique et d'un agent oxydant, un composé contenant de l'ammonium, et un composé contenant du nitrite dans la formation de grès, l'un ou les deux parmi le précurseur générant de l'acide fluorhydrique et l'agent oxydant comprenant une encapsulation dégradable. Le procédé comprend en outre le maintien du fluide de stimulation, du composé contenant de l'ammonium et du composé contenant du nitrite dans la formation de grès pour initier la réaction et générer de la chaleur et de l'azote gazeux. Lors de la génération de chaleur et de la dégradation de l'encapsulation dégradable, le précurseur générant de l'acide fluorhydrique et l'agent oxydant réagissent pour former de l'acide fluorhydrique in situ afin de dissoudre la silice et les minéraux de silicate et stimuler la formation de grès. Un fluide de traitement destiné à être utilisé dans la stimulation de formations de grès comprend le fluide de stimulation, le composé contenant de l'ammonium et le composé contenant du nitrite.
Patent WO-2021230856-A1 (WO)
Title: Eyebox steering and field of view expansion using a beam steering element
Inventor: CAKMAKCI OZAN
IPC: G02B27/01
Filed: 2020-05-12
Abstract: An eyewear device includes a lightguide having a world-side surface and an eye-side surface, a display oriented to emit light toward the lightguide, and a beam steering element that includes a first polarization grating positioned along an optical path between the display. The first polarization grating diffracts light emitted by the display into orders having different polarizations and the orders are selectively conveyed into different eyeboxes. The eyewear device also includes a frame that supports the lightguide, the display, and the first polarization grating. In some cases, the different polarizations include a right circular polarization or a left circular polarization and the beam steering element includes a polarization dependent filter that filters right circularly polarized light in a first state and left circularly polarized light in a second state.
Patent WO-2021206741-A1 (WO)
Title: Modulating neurotransmitter concentration
Inventor: DELAHOUSSAYE KEVIN
IPC: A61N1/36
Filed: 2020-05-29
Abstract: Each receptor in question should be bound to only one molecule. The current approach is to create a molecule that 'does it all'. The most effective, efficient, and easy way to modulate the concentration of neurotransmitters in the body is to be specific, one molecule should only bind to one receptor. The current method uses molecules that bind the receptor in many different active sites which does not allow for flexibility or proper and precise modulation. Neuroscience: Each receptor in question should be bound to only one molecule. The current approach is to create a molecule that 'does it all'. The most effective, efficient, and easy way to modulate the concentration of neurotransmitters in the body is to be specific, one molecule should only bind to one receptor. The current method uses molecules that bind the receptor in many different active sites which does not allow for flexibility or proper and precise modulation.
Patent WO-2020243501-A1 (WO)
Inventor: BOISVERT RONALD
IPC: F16K3/16
Filed: 2020-05-29
Abstract: A sheet material is provided that includes a woven layer having a first side and an opposing second side, the woven layer formed from strand including a polyolefin polymer and a nucleating agent; a first polymeric coating disposed on the first side of the woven layer; and optionally a second polymeric coating disposed on the second side of the woven layer. The sheet material exhibits reduced thermal shrinkage.
Patent WO-2020252199-A1 (WO)
Title: Utility connection systems, splines, and associated methods
Inventor: ALLEN DEAN
IPC: F24F110/65
Filed: 2020-06-11
Abstract: A utility connection system can include a primary utility spline having a length and a support frame. The utility connection system can include one or more utility conduits extending along at least a portion of the length of the primary utility spline and supported by the support frame. The system can include a sensor hub including one or more sensors; and one or more branch access interfaces having one or more ports in communication with the one or more utility conduits. The utility connection system can include a branch utility spline connected to the primary utility spline at the one or more branch access interfaces.
Patent WO-2020257637-A1 (WO)
Inventor: APPEL ERIC A
IPC: G01N33/92
Filed: 2020-06-19
Abstract: Provided herein are compositions including lipids and copolymers in the form of a nanodisc assembly. The subject copolymers include monomer units of styrene and monomer units selected from acrylic acid and an acrylic acid derivative. In certain cases, the copolymer is a copolymer of styrene and acrylic acid. Also provided herein, is an aqueous solution comprising the subject composition. Also provided herein, are methods for producing a nanodisc assembly, including incubation of a lipid and a subject copolymer. Further provided herein, are methods for solubilizing a membrane protein in an aqueous solution, wherein the method includes forming a nanodisc assembly of a lipid bilayer having one or more membrane proteins embedded therein, and a subject copolymer. Also provided are methods of solubilizing a hydrophobic constituent in an aqueous solution, including forming a nanodisc assembly of a lipid, a hydrophobic constituent, and a subject copolymer.
Patent WO-2020263950-A1 (WO)
Inventor: NIKOLSKIY SERGEY
IPC: A61C13/00
Filed: 2020-06-24
Abstract: A computer-implemented method and system of determining a material surface from a volumetric density file includes generating a density frequency distribution of a volumetric density file of a dental impression and determining an iso-value of density between air and a particular material in the density frequency distribution. A computer-implemented method and system of creating a digital model from a CT scan of a physical dental impression includes selecting an iso-value of density for a digital volumetric density file having one or more voxels, generating one or more digital surface points in virtual 3D space for each of one or more voxels, and selecting a subset of digital surface points from the one or more digital surface points. A computer-implemented method and system of optimizing a digital surface includes moving one or more digital surface points to satisfy a criteria of optimum digital surface selection.
Patent WO-2021007338-A1 (WO)
Inventor: LU XUANYONG
IPC: A61P35/00
Filed: 2020-07-08
Abstract: Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose and/or treat disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed.
Patent WO-2021007488-A1 (WO)
Inventor: Panarese Joseph
IPC: A61K31/4353
Filed: 2020-07-10
Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Patent WO-2021011535-A1 (WO)
Inventor: DRAKE RONALD A
IPC: A61M25/00
Filed: 2020-07-14
Abstract: An active return curve deflectable catheter (100) includes an elongate member (102), a fixation member (122), a deflection assembly (104), and a pull wire (126). The fixation member is coupled to a distal portion of the elongate member. The deflection assembly includes a hub assembly coupled to a proximal end of the elongate member, a handle, and a control member. The pull wire extends from the control member through the hub assembly to the fixation member. The elongate member is configured to deflect from an initial configuration to a deflected configuration in response to a pull force applied to the pull wire by actuation of the control member in a first direction.
Patent WO-2021021462-A1 (WO)
Inventor: RIGANO ANTONINO
IPC: H01L27/06
Filed: 2020-07-16
Abstract: Some embodiments include an integrated assembly having a pillar of semiconductor material. The pillar has a base region, and bifurcates into two segments which extend upwardly from the base region. The two segments are horizontally spaced from one another by an intervening region. A conductive gate is within the intervening region. A first source/drain region is within the base region, a second source/drain region is within the segments, and a channel region is within the segments. The channel region is adjacent to the conductive gate and is vertically disposed between the first and second source/drain regions. Some embodiments include methods of forming integrated assemblies.
Patent WO-2021021926-A1 (WO)
Inventor: WALDERN JONATHAN
IPC: G06T3/40
Filed: 2020-07-29
Abstract: Systems and methods for multiplying the resolution and field-of-view of pixelated displays in accordance with various embodiments of the invention are illustrated. One embodiment includes an apparatus having an image projector for directing light from a pixelated image source into unique angular directions, an image processor electrically connected to the image projector for computing native images of the image source corresponding to first and second field-of-view portions and for computing shifted images in a predefined direction corresponding to the first and second field-of-view portions for sequential display by the image projector, a first set of gratings having a native configuration for propagating the light of the native image and at least one shifted configuration for propagating the light of at least one shifted image, and a second set of gratings having a first configuration for projecting the first field-of-view portion and a second configuration for projecting the second field-of-view portion.
Patent WO-2021026159-A1 (WO)
Inventor: FANG LINN
IPC: C07C69/15
Filed: 2020-08-04
Abstract: Purification methods and systems for working up a crude vinyl acetate stream containing vinyl acetate monomer, acetic acid, water, ethyl acetate, and other impurities. Crude vinyl acetate streams are purified with an azeotropic distillation tower using a side draw to remove ethyl acetate and water, and a bottom stream to remove acetic acid from the crude vinyl acetate. The methods and systems move the side draw to a location on the azeotropic distillation tower that maintains a constant water concentration in the bottom product of about 4 to about 15 wt. % and forms a vapor side product. A second distillation tower is used to further purify the vapor side product to obtain water, VAM, ethyl acetate and AA. The system provides easier disposal of ethyl acetate, and cleaner water that can be recycled in the reactor or purification sections of a VAM plant and full recovery of AA.
Patent WO-2021050480-A1 (WO)
Title: Shiplift platform elevation
Inventor: TAYLOR ROBERT
IPC: E02C5/00
Filed: 2020-09-09
Abstract: A shipyard including a shiplift platform that is capable of being raised above yard level for maintenance is provided. Hoists are coupled with the shiplift platform, and jacks are coupled with the hoists. The jacks are capable of lifting the hoists relative to the yard, and are capable of lifting the shiplift platform above the yard level.
Patent WO-2021050649-A1 (WO)
Title: Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
Inventor: GASMI MEHDI
IPC: C12N7/00
Filed: 2020-09-10
Abstract: Provided are methods for treating an ocular neovascular disease in an individual, comprising administering a unit dose of recombinant adeno-associated virus (rAAV) particles to an eye of the individual, wherein the rAAV particles comprise: a) a nucleic acid encoding a polypeptide comprising an amino acid sequence with at least about 95% identity to the amino acid sequence of SEQ ID NO: (35) and flanked by AAV2 inverted terminal repeats (ITRs), and b) an AAV2 capsid protein comprising an amino acid sequence LGETTRP (SEQ ID NO: (14)) inserted between positions (587) and (588) of the capsid protein, wherein the amino acid residue numbering corresponds to an AAV2 VP1 capsid protein.
Patent WO-2021050839-A1 (WO)
Title: Techniques for determining fetal situs during an imaging procedure
Inventor: BUROS JULIE
IPC: A61B8/00
Filed: 2020-09-11
Abstract: Techniques for determining fetal situs during an ultrasound imaging procedure are disclosed. The techniques can include obtaining an ultrasound image of a fetus in utero. The fetus will include a torso and a spine and the ultrasound image can comprise a circumferential view of the torso of the fetus. The circumferential view can include at least: (i) an outer border of the torso, and (ii) the spine that includes three landmarks arranged in a triangular orientation. The techniques can further include superimposing a fetal overlay based on an alignment instruction corresponding to an alignment between the outer border of the torso and the three landmarks to obtain an augmented reality image of the fetus. The fetal overlay can include a graphical element indicating a left side and a right side of the fetus. The augmented reality image of the fetus can be output on a display of the ultrasound machine.
Patent WO-2021067389-A1 (WO)
Inventor: KROETSCH ANDREW
IPC: A61P7/04
Filed: 2020-09-30
Abstract: L'invention concerne des formulations de vecteur lentiviral (LV), et des compositions pharmaceutiques comprenant de telles formulations de LV, ayant une stabilité améliorée et convenant à une administration systémique. L'invention concerne également des méthodes de traitement de troubles, en particulier de troubles sanguins, par l'administration systémique de formulations de LV.
Patent WO-2021071790-A1 (WO)
Title: System and method for reducing printable defects on extreme ultraviolet pattern masks
Inventor: YANG XIAOCHUN
IPC: G03F1/84
Filed: 2020-10-06
Abstract: A system for reducing printable defects on a pattern mask is disclosed. The system includes a controller configured to be communicatively coupled to a characterization sub-system, the controller including one or more processors configured to execute program instructions causing the one or more processors to: direct the characterization sub-system to perform inspection of a mask blank; generate a cost function based on a first characteristic and a second characteristic, the first characteristic comprising areas of defect regions exposed by mask patterns, the second characteristic comprising pattern complexity of a design pattern; determine one or more values indicative of a minimum of the cost function via a non-linear optimization procedure; and generate one or more control signals to adjust rotation and translation of the mask blank relative to the design pattern based on the determined one or more values indicative of the minimum of the cost function.
Patent WO-2021118682-A1 (WO)
Inventor: WU BANQIU
IPC: G03F1/82
Filed: 2020-10-14
Abstract: Embodiments of the present disclosure generally provide apparatus and methods for removing an adhesive material from a photomask. In one embodiment, an apparatus for processing a photomask includes an enclosure, a substrate support assembly disposed in the enclosure, and a dielectric barrier discharge (DBD) plasma generator disposed above the substrate support assembly, wherein the dielectric barrier discharge plasma generator further comprises a first electrode, a second electrode, wherein the first and the second electrodes are vertically aligned and in parallel, a dielectric barrier positioned between the first electrode and the second electrode, and a discharge space defined between the dielectric barrier and the second electrode.
Patent WO-2021091828-A1 (WO)
Title: Thermoplastic elastomer composition
Inventor: FOSTER HEITH
IPC: C08L53/02
Filed: 2020-11-02
Abstract: A thermoplastic elastomer composition possessing a good combination of elastic recovery, tear strength at 25°C, stress relaxation and reduced (improved) anisotropy, which is based on a hydrogenated block copolymer (A), a thermoplastic resin (B), a rubber softener (C) and a polyolefin elastomer (D), of specified types and proportions, and which is suitable for use in a variety of film and sheet applications.