Patent SG-11201811614Y-A (SG)
Title: Flow cell assembly securement system and method
Inventor: DE RUYTER ANTHONY JOHN
IPC: G01N1/00
Filed: 2017-11-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property C.--.` MD HIM 011101011M 01 11010101101 MO Ell 1101 1111111011110111 OEN Organization International Bureau (10) International Publication Number 03 (43) International Publication Date ......P' WO 2018/097998 Al 31 May 2018 (31.05.2018) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every GO1N 1/00 (2006.01) G01N 33/483 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/061824 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 15 November 2017 (15.11.2017) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (30) Priority Data: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 15/359,848 23 November 2016 (23.11.2016) US (84) Designated States (unless otherwise indicated, for every N2017853 23 November 2016 (23.11.2016) NL kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Way, San Diego, California 92122 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: DE RUYTER, Anthony John; 5200 Illumina EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Way, San Diego, California 92122 (US). KEHL, Patrick; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 5200 Illumina Way, San Diego, California 92122 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, _ MCGEE, Thomas; 5200 Illumina Way, San Diego, Cali- KM, ML, MR, NE, SN, TD, TG). fornia 92122 (US). = Declarations under Rule 4.17: (74) Agent: WU, Bruce; 5200 Illumina Way, San Diego, Cali- _ as to applicant's entitlement to apply for and be granted a = fornia 92122 (US). patent (Rule 4.1700) = = (54) Title: FLOW CELL ASSEMBLY SECUREMENT SYSTEM AND METHOD (57) : A flow cell and cartridge assembly may be loaded into a pro- cessing system, such as for genetic sequencing. The system locates the assem- - 16--,,sAMPLE bly is desired reference position in = 10 and then actuated to move the assembly to a 18Th I both X- and Y-directions. Further actuation causes clamps to contact the flow = SAMPLE PREPARATION SYSTEM ARRAY cell, the cartridge, or both to exert a hold-down force during processing. Further = 12-- ) 20-Th hold-down forces be by Fluid may provided a vacuum chuck. connections are — FLOW CELL 22 Th also made by manifolds that contact the flow cell. The hold-down forces coun- = SEQUENCING INSTRUMENT _ CARTRIDGE I teract the forces needed for sealing the manifolds to the flow cell. = STAGE AND STAGE CONTROL CIRCUITRY 24 H = 26 = —.. IMAGING SYSTEM AND CONTROL CIRCUITRY L. h -- ) = — 28 14 — I FLUIDICS SYSTEM AND CONTROL CIRCUITRY h_J — 1 30 INSTRUMENT CONTROL SYSTEM 1 , r-32 ; PROCESSING CIRCUITRY I ' 11 • EXTERNAL/REMOTE SYSTEMS /MEMORY MEMORY CIRCUITRri 4 7 40- ) ,--36 GC INTERFACE CIRCUITRY I , C:7 I ( --38 I Ir ... ' I OPERATOR INTERFACE I C:7 1 © \... GC FIG. 1 1-1 0 N C [Continued on next page] WO 2018/097998 Al MIDEDIMOMOIDEIREIERIEHEIMOIMOMEHOIS Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of