Patent SG-11201803976V-A (SG)
Title: Polypeptides inhibiting cd40l
Inventor: PATTYN ELS
IPC: C07K16/46
Filed: 2016-11-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date .... ..sr.) 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/089618 Publication 111111111111111111111111111111111111 Al Number In (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/18 (2006.01) C07K 16/46 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 16/28 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2016/079048 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 28 November 2016 (28.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/260,411 27 November 2015 (27.11.2015) US (84) Designated States (unless otherwise indicated, for every 62/345,967 6 June 2016 (06.06.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: ABLYNX NV [BE/BE]; Technologiepark 21, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 9052 Ghent-Zwijnaarde (BE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: PATTYN, Els; Beertegemstraat 46, 9750 Huise LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (BE). SOMPEL, Ariella Van de; Hollenaarstraat 94, 9401 Oostakker (BE). MEERTS, Peter; Nieuwe Molenstraat SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 27B, 9160 Lokeren (BE). BUYSE, Marie-Ange; GW, KM, ML, MR, NE, SN, TD, TG). Burgemeester Edmond Ronsestraat 23, 9820 Merelbeke Published: DEWILDE, Maarten; Bergemeersenstraat 109, (BE). — 21(3)) 9300 Aalst BESTE, Gerald; Jozef Kluyskensstraat with international search report (Art (BE). 25, bus 20, 9000 Gent (BE). VLACH, Jaromir; 2 Steeple — before the expiration of the time limit for amending the Chase Circle, Westford, Massachusetts 01886 (US). HSU, claims and to be republished in the event of receipt of Jonathan; 51 Taylor St., Apt 4, Waltham, Massachusetts amendments (Rule 48.2(h)) 02453 (US). — with sequence listing part of description (Rule 5.2(a)) (74) Agents: STEFFERL, Andreas et al.; HOFFMANN EITLE PARTMBB, ArabellastraBe 30, 81925 Munich (DE). 1-1 .4t GC Il O\ GC 0 -- - It 1-1 (54) Title: POLYPEPTIDES INHIBITING CD4OL 0 N (57) : The present invention relates to immunoglobulins that specifically bind CD4OL and more in particular to poly - ega ) peptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of CD4OL and are safe.