baber/WOPTO huggingface dataset:
Patent PT-996462-E (PT)
Inventor: LEHMANN PAUL
IPC: A61K38/16
Filed: 1998-06-03
Abstract: The invention relates to pharmaceutical combination preparations containing erythropoietin and one or several modified haemoglobins. The inventive combination preparations are used especially for treating manifest anaemia. The inventive pharmaceutical combination preparation comprises a) individual forms of administration of an erythropoietin preparation suitable for an individual dose of a quantity of 3,000 - 7,000 U of the active agent and b) 50 - 100 ml of one or several modified haemoglobins. The erythropoietin preparation and the modified haemoglobin can be provided in separate or single forms of administration.
Patent PT-1007020-E (PT)
Inventor: BOLLAG WERNER
IPC: A61P37/00
Filed: 1998-08-18
Abstract: 9-cis retinoic acid and pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, 9-cis retinal and pharmaceutically acceptable acetals thereof, and 9-cis retinol and pharmaceutically acceptable hydrolyzable esters thereof have been found to be efficacious in treating T-helper cell type 1 mediated immune diseases in well tolerated doses. Preferably, the active ingredient is formulated as a medicament for oral or topical administration.
Patent PT-1032429-E (PT)
Inventor: ERDILE LORNE
IPC: A61K48/00
Filed: 1998-11-20
Abstract: The present invention relates to the use of a solution comprising a non-infectious DNA molecule able to express in a mammal, a physiologically active protein, for the manufacture of a medicament intended to be delivered mainly to the mammalian skin using a needle-free apparatus adapted to this effect. The physiologically active protein can be an antigen that is (i) specific for a microorganism able to induce an infection in a mammal or (ii) tumor-associated; in this case the medicament is for treating or preventing an infection or a tumor disorder. The protein can also be a mammalian protein able to treat a genetic defect e.g., factor XIII or IX; or a cytokine.
Patent PT-1036516-E (PT)
Inventor: MOLINA GIUSEPPE
IPC: A43D25/18
Filed: 1999-03-18
Abstract: In a machine (1) for pulling over and lasting an upper on a corresponding shoe form with which an insole is associated, the means for supplying the glue onto the insole comprise a supply plate (19) formed by two segments (19a) which are hingeably joined together so as to be hingeably adjustable and provided with a plurality of nozzles (20) for supplying the glue along the contour (27) of the front portion of the insole. The abovementioned means for supplying the glue comprise two further nozzles (22) which are movable so as to follow the contour of the insole starting from the supply plate (19).   <IMAGE>   <IMAGE>
Patent PT-1097591-E (PT)
Inventor: ARDEMAGNI FIORENZO
IPC: H04N7/173
Filed: 1999-06-18
Abstract: The invention relates to an optimized system for distribution of television and telecommunication services from a peripheral node to user terminals (10, 11, 12) comprising a bi-directional switch exchange (1) connected to said peripheral node, a facility (7) for bi-directional distribution of signals connected to said exchange (1) and at least one user apparatus (9) connected to said user terminals (10, 11, 12), said exchange (1) receiving from said peripheral node the signals belonging to said television and telecommunication services and from said bi-directional distribution facility (7) a local upstream data sequence including the television channel selection signals, said exchange (1) selecting some input signals belonging to television services and reallocating and/or frequency transmodulating them in order to transmit them, in combination with a local downstream data sequence, to said signal bi-directional distribution facility (7), said user apparatus (9) processing said local downstream data sequence and generating said local upstream data sequence to be transmitted to said exchange (1) together with the upstream data and/or voice channels related to said telecommunication services.
Patent SG-31789-G (SG)
Title: Brushing and continuous lubrifying device for rolling cyclinders for flat rolled products
IPC: B21B3/00
Filed: 1989-05-18
Abstract: Apparatus for continuously brushing and lubricating rolls of rolling mills for rolled flat products without pollution of said products by the lubricant used; it can be used in hot or cold rolling, in particular for Al or alloys thereof. An enclosure of general parallelepipedic shape which is open on one face and whose opposite sides which are adjacent to the opening are delimited by a circular arc, the radius of which is substantially equal to that of the roll, is applied thereto by way of a continuous resilient peripheral seal. The enclosure which contains the rotary brushes is lubricated by oil circulation and is under a slight depression.
Patent IE-32613-L (IE)
Title: Tyres, tread composition
IPC: B60C11/18
Filed: 1969-01-13
Abstract: 1,255,952. Pneumatic tyres. DUNLOP HOLDINGS Ltd. 9 Jan., 1969 [12 Jan., 1968], No. 1770/68. Heading B7C. To provide improved wet grip when in a worn state a pneumatic tyre comprises in the unworn state a tread 1 which has a radially outermost layer 3 of abrasion resistant tread rubber composition, an intermediate layer 4 of a second rubber composition which has a higher braking coefficient on wet surfaces than that of the composition of layer 3, and a radially innermost sub-tread 5 of rubber composition having a lower hysteresis value than the remainder of the tread rubber. The tread 1 has circumferentially extending grooves 2 and the layer 4 undulates to extend both radially inwardly of the groove bases, and radially outwardly between the grooves a distance of up to 50% of the groove depth. In modifications, the layer 4 may be disposed solely in one or both tread shoulders 9, or solely in the crown region 8, and the subtread 5 may be disposed solely in the tread shoulder regions.
[GB1255952A]
Patent IE-890066-L (IE)
Title: Process for the preparation of enantiomer-pure 2,2,4-trisubstituted 1,3-dioxolanes
IPC: C07D317/28
Filed: 1989-01-11
Abstract: Process for the preparation of pure enantiomers of 2,2-disubstituted 1,3-dioxolane-4-methanols or N,2,2-trisubstituted 4-aminomethyl-1,3-dioxolanes from the corresponding cyclic ketals of erythronic or threonic acid or their salts by electrochemical oxidative decarboxylation and subsequent reduction or reductive amination.
Patent IE-790109-L (IE)
Title: Contactor
IPC: H01H50/30
Filed: 1979-01-30
Abstract: A contactor has a body constituted by a base common to two parallel walls each having on its internal face a rib to guide fixed elements of a removable electro-magnet having means to cooperate with the ribs. The fixed elements form a slide having resilient locking means cooperating with stop means on an adjacent wall such that, in a first position, the core is disposed opposite the armature, the core being assembled to the body by first support members, and the winding being secured to the body by its own independent support members. In a second position, the core remains engaged with the body and extends from the body so that the winding support means are freed from the rib, and the winding can be separated from the core.
[US4253076A]
Patent IE-34955-L (IE)
Title: Purification of esters
IPC: C07C67/48
Filed: 1971-02-18
Abstract: 1279203 Purification of esters IMPERIAL CHEMICAL INDUSTRIES Ltd 19 April 1971 [18 March 1970] 13036/70 Heading C2C The acidity of an ester product of an esterification reaction is reduced by contacting the ester with steam and a finely divided solid alkali at a temperature greater than 100 C. The ester may be derived from a saturated mono-, di- or tri-basic aliphatic or aromatic acid and a saturated mono-, di- or tri-basic aliphatic or aromatic alcohol. The alkali is suitably an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate, or an ammonium carbonate or bicarbonate. Examples describe the production of plasticizer esters for P.V.C. by heating orthophthalic acid or phthalic anhydride in the presence of a titanium catalyst and an excess of one or more (C 4 -C 14 ) alkanols to 200-270 C., adding solid Na 2 CO 3 , reducing the pressure, admitting steam at 200-210 C. and removing excess alcohol at 140-210 C.
[GB1279203A]
Patent IE-820363-L (IE)
Title: Isolation valve
IPC: C23C16/54
Filed: 1982-02-22
Abstract: A valve for isolating the interior of a glow discharge chamber from the atmosphere and other reactants. The valve includes a body mounted in an aperture of the chamber. A slit-like opening is provided therein to allow the interior of the chamber to communicate with interrelated elements of a deposition system. A source is provided for introducing inert gas into the opening under pressure somewhat greater than that of reaction gases and plasma within the chamber to create an effective, non-reactive gas curtain.
[EP0060626A2]
Patent IE-33154-L (IE)
Title: Composite web e.g. for artificial leather
IPC: D04H1/46
Filed: 1969-04-09
Abstract: 1,264,034. Coated products. TENNECO CHEMICALS Inc. 8 April, 1969 [5 April, 1968], No. 17974/69. Heading B2E. [Also in Divisions B4 and B5] A composite web the density of which increases from a first surface to the other surface thereof, comprising a base web which is an interlocking fleece of randomly oriented and distributed fibres disposed in a foam material, e.g. polyurethane foam, with void spaces therebetween, one surface of the base web comprising said first surface, and a second fleece mechanically bonded to the other surface of said base web and formed of fibres the denier of which is no greater than the denier of said randomly oriented fibres, said fibres forming the second fleece having fine interstices therebetween and being predominantly in a single plane parallel to the surface of the web, may be made by physically forcing a plurality of fibres into a foam material, e.g. by needling to form the base web, mechanically bonding the second fleece to the base web, e.g. by needling and subjecting the product to a temperature of from 250‹F to 375‹F at a pressure of from 5 to 100 pounds per square inch for from 20 seconds to 5 minutes. A sheet composition suitable for use as an artificial leather may be formed from the composite web by substantially but not completely filling said void spaces and said interstices with a soft, resilient elastomeric filler, e.g. a polyurethane or a butadiene-acrylonitrile copolymer, the filling being optionally followed by a further application of heat and pressure. Alternatively, the exposed surface of the second fleece may be coated with an elastomeric polyurethane. The fibres may be in the form of tow, staple or continuous filaments, may be crimped or uncrimped, may be mixed and may comprise nylon-6,6, nylon-6, polyethylene terephthalate, polydimethylcyclohexyl terephthalate, polyacrylonitrile, polyvinyl chloride, polyvinyl alcohol, rayon, cellulose triacetate or wool.
[GB1264034A]
Patent IE-39166-L (IE)
Title: N-substituted acetamide pharmaceuticals.
IPC: C07C233/00
Filed: 1974-03-14
Abstract: 1436593 Substituted acetamides SCIENCE UNION ET CIE SOC FRANCAISE DE REMEDICALE 15 March 1974 [15 March 1973] 12430/73 Heading C2C Novel substituted acetamides of the Formula I in which R 1 is H or C 1 -C 6 alkyl; R 2 and R 3 each are C 1 -C 6 alkyl, cycloalkyl or aryl; R 6 is H or C 1 -C 6 alkyl; R 4 is H, C 1 -C 6 alkyl, C 2 -C 10 alkenyl or benzyl; R 5 is C 1 -C 6 alkyl, C 2 -C 10 alkenyl, C 2 -C 6 alkynyl or aryl-C 1 -C 4 alkyl; or R 4 and R 5 together with the nitrogen atom to which they are attached form a 5 to 8 membered saturated heterocyclic ring which is optionally substituted and may contain a further hetereo atom, and R<SP>1</SP> is H or acyl, and the acid addition salts thereof are prepared by reaction carboxylic acids of the formula or reactive functional derivatives thereof with amines of the formula compounds of the Formula I above in which R 4 is H may also be obtained by the hydrogenolysis or acid hydrolysis of the corresponding compounds in which R 4 is benzyl, and those in which R<SP>1</SP> is acyl by acylating the corresponding compounds in which R<SP>1</SP> is H. (2,2<SP>1</SP>,6,6<SP>1</SP> - Tetramethyldiphenyl)acetyl chloride is prepared by reacting thionyl chloride with the acid, resulting from the hydrolysis of the corresponding nitrile, which is made by reacting silver cyanide with (2,21,6,61-tetramethyldiphenyl)chloromethane. Similarly the following are prepared: (4,41 - difluorodiphenyl)acetyl chloride, (4,4<SP>1</SP> - difluorodiphenyl)acetic acid, and (4,4<SP>1</SP>-difluorodiphenyl)acetonitrile. Dicyclopropylacetyl chloride is prepared by reacting thionyl chloride with dicyclopropylacetic acid, obtained by oxidizing dicyclopropylacetaldehyde. (2,2<SP>1</SP>,3-Trimethoxy-5<SP>1</SP>-methyldiphenyl)acetic acid and (2-methoxy-2<SP>1</SP>-methylthio- 5<SP>1</SP>-methyldiphenyl)acetic acid are also obtained by oxidating the corresponding acetaldehydes. Pharmaceutical compositions, suitable for oral, parenteral, sublingual or rectal administration, contain the above compounds or non- toxic acid addition salts thereof in admixture or conjunction with pharmaceutical carriers. The compounds anti-arhythmic, cardio-depressive, vasodilatory, anti-hypertensive and anti-aggregating properties.
[GB1436593A]
Patent IE-880558-L (IE)
Title: Stable gene amplification in prokaryotic chromosomal dna
IPC: C12N1/20
Filed: 1988-02-29
Abstract: Transformed prokaryotic hosts are provided comprising two or more copies of a DNA sequence stably maintained in their chromosome, said sequence comprising a gene encoding a polypeptide of interest, wherein said copies are separated by endogenous chromosomal DNA sequences. Methods are also provided for producing said transformed host strains. Said transformed host strains are capable of increased production of the polypeptide of interest compared to host strains which already produce said polypeptide. Preferred host strains are Bacillus novo species PB92 which produces a high-alkaline proteolytic enzyme and Bacillus licheniformis T5 which produce a thermostable alpha-amylase, and mutants and variants of said strains. Preferred polypeptide encoding genes are the protease encoding gene originating from Bacillus PB92 and the alpha-amylase encoding gene originating from Bacillus licheniformis strain T5.
[EP0284126A1]
Patent IE-39351-L (IE)
Title: Fire screening glazing panel
IPC: E04B/
Filed: 1974-03-27
Abstract: The invention relates to a fire screening glazing panel and a method for forming the panel. The panel is composed of at least two structural plys, at least one of which is a vitreous sheet, and a layer therebetween composed at least in part of a heat convertible carrier forming material which material forms a solid porous or cellular thermally insulating body when subjected to sufficient heat, as during a fire. A protective stratum is applied to at least one of the vitreous sheet plys for inhibiting interaction between the barrier forming material and the ply, thereby maintaining the transparency of the ply if it is formed of transparent material, and maintaining its color.
Patent IE-34683-L (IE)
Title: N-oxides of benzylpyrimidines.
IPC: C07D239/48
Filed: 1970-06-09
Abstract: Antibacterially active N-oxides of 2,4-diamino-benzylpyrimidines are described.
[US3715357A]
Patent IE-830795-L (IE)
Title: Process for preparing 1, 2, 5 (6)-trisubstituted¹benzimidazole.
IPC: C07D417/04
Filed: 1983-04-07
Abstract: This invention concerns a process for preparing 2-amino-1,5(6)-substituted-benzimidazole compounds by reacting a 1-unsubstituted-2-amino-5(6)-substituted-benzimidazole compound with a sulfonyl chloride or a haloalkyl isothiocyanate in the presence of an alkali metal hydroxide or carbonate, water, and a water-miscible nonhydroxylic solvent.
Patent FI-822398-L (FI)
Inventor: BETHGE HORST
IPC: C07C323/58
Filed: 1982-07-06
Abstract: There is described the resolution of the racemate S-(carboxymethyl)-(RS)-cysteine. It is carried out by means of the optical isomers of 1-phenyl-ethylamine. This process makes it possible to obtain in a simple manner S-(carboxymethyl)-(R)-cysteine which is important for pharmaceutical purposes and is made from synthetically produced cysteine.
Patent FI-853094-L (FI)
Inventor: HILDENBRANDT LOTHAR
IPC: A63C5/056
Filed: 1985-08-13
Abstract: 1. A method for the manufacture of ski bottom coatings from thermoplastic webs (2) made the basis of extrusion and calendering techniques known per se, to which webs modification materials (5) are applied and rolled in at temperatures of 70 degrees C to 250 degrees C, characterized in that the modification material (5) is applied to the thermoplastic web (2) by means of one or several vacuum-exposed hollow roll(s) (6) which is (are) arranged within the region of a calender (3) and connected with a control for path-dependent movement to and away from a counterroll (15), the modification material (5) being taken from a material holding and supplying means (4; 7) by the vacuum applied to the hollow roll (6), distributed over the circumference of the hollow roll (6) during its rotation and - when the predetermined modification area of the thermoplastic web (2) is reached - being applied to it at equal peripheral speed of the hollow (6) to the thermoplastic web (2) passed to calender (3) the application process being terminated after passing the modification area when the hollow roll (6) has been moved away and its rotation stopped, and that the thermoplastic web (2) treated in this way is fed to the subsequent calendering procedure for intensively working in the modification material (5).
Patent IE-36892-L (IE)
Title: Phenothiazines
IPC: C07D279/28
Filed: 1972-08-23
Abstract: 1338124 Phenothiazines MAY & BAKER Ltd 23 Aug 1972 [25 Aug 1971] 39854/71 Heading C2C Compounds of the general formula (R<SP>6</SP>=Me, Et) and their acid addition salts are prepared by (a) reacting a compound of the formula (A = CO or protected CO) with (X<SP>1</SP>=reactive ester residue, carbamate, mono- or dialkylcarbamate or alkyl carbonate), (b) decarboxylating a compound of the formula or (c) reacting a compound of the formula (X<SP>2</SP>=reactive ester residue) with dimethylamine, followed in each case by removal of the protecting group if present and (optionally) salt formation. The preparation of 8-chloro-2-propionylphenothiazine, 2 - acetyl - 8 - chlorophenothiazine anil, 2 - acetyl - 8 - chlorophenothiazin - 10 - ylcarbonyl chloride, 2 - acetyl - 8 - chloro - 10 - (3 - dimethylamino - 2 - methylpropyloxycarbonyl)phenothiazine and its hydrochloride and 2-acetyl-8-chloro-10-(3- chloro - 2 - methylpropyl) phenothiazine is described. The above compounds are useful in the relief of upper motor neurone (pyramidal) spasticity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
[GB1338124A]
Patent IE-36968-L (IE)
Title: 1,4-disubstituted-2(1h)-quinazolinones
IPC: C07D317/68
Filed: 1972-11-30
Abstract: 1385420 Preparation of 1,4-disubstituted- 2(1H)-quinazolinones SANDOZ Ltd 31 Oct 1972 [18 Nov 1971] 50104/72 Heading C2C A compound of formula wherein R 1 represents C 1-5 alkyl group (other than a tertiary alkyl radical in which the tertiary carbon atom is directly attached to the ring nitrogen atom), an allyl, methallyl orpropargyl radical; R 2 and R 3 , which may be the same or different, each signifies a hydrogen, fluorine, chlorine or bromine atom, an alkyl, alkylthio or alkoxy radical of 1 to 3 carbon atoms or a nitro or trifluoromethyl group, provided that no more than one of R 2 and R 3 signifies an alkylthio radical or a nitro or trifluoromethyl group, and R 4 signifies a radical of formula in which Y 1 and Y 2 , which may be the same or different, each signifies a hydrogen, fluorine, chlorine or bromine atom, an alkyl or alkoxy group of 1 to 3 carbon atoms or a trifluoromethyl group, provided that no more than one of Y 1 and Y 2 signifies a trifluoromethyl group, provided that when R 1 signifies an isopropyl radical R 2 signifies a 7-methyl radical and R 3 signifies a hydrogen atom, then R 4 signifies other than a pfluorophenyl radical, is prepared by cyclizing a compound of formula in which R 1 , R 2 , R 3 and R 4 are as defined above, at a temperature of at least 80‹ C. and in the presence of a C 2-4 carboxylic acid, at least 3 moles of urea per mole of the compound III being employed.
[GB1385420A]
Patent IE-821570-L (IE)
Title: Use of eucalyptol for enhancing skin permeation of¹bioaffecting agents
IPC: A61K47/00
Filed: 1982-06-29
Abstract: Greatly enhanced delivery of a wide variety of bio- , affecting agents is provided by formulations for topical application comprising at least one bio-affecting agent and eucalyptol. Optionally, the formulation can further comprise a non-toxic topical carrier and/or an additional penetration enhancer. The eucalyptol acts as a unique transport agent which readily delivers the active bio-affecting agent across the stratum corneum to the target area. Cosmetic and therapeutic dermatological agents as well as systematically effective therapeutic agents can be easily formulated with eucalyptol and effectively delivered through the skin to the desired site, i.e., to the underlying tissues of the epidermis and dermis or to the general circulation.
Patent IE-871652-L (IE)
Title: T-butyl-ergoline derivatives
IPC: C07D457/02
Filed: 1987-06-22
Abstract: Ergoline derivatives of general formula I <CHEM> wherein either R1 represents a hydrogen atom or a methoxy group and R2 represents a hydrogen atom or R1 and R2 taken together represent a chemical bond, and R3 represents a hydrogen atom, an unsubstituted or substituted nicotinoyl group or a 1-oxo-2-cyclopenten-3-yl group; or a pharmaceutically acceptable salt thereof are active at the Central Nervous System level and useful therefore in the treatment of cerebral insufficiency and senile dementia.
Patent IE-43931-L (IE)
Title: Homophthalimides
IPC: A61K31/472
Filed: 1976-07-30
Abstract: Compounds of the formula  wherein A and B, which may be identical to or different from each other, are each straight alkylene of 2 to 4 carbon atoms which may have a methyl or phenyl substituent attached thereto, R1, R2, R3 and R4, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, hydroxyl, amino, nitro, acetylamino, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or (alkyl of 1 to 3 carbon atoms)thio, R5, R6, R7 and R8, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 4 carbon atoms, phenyl-(alkyl of 1 to 4 carbon atoms) or methoxyphenyl-(alkyl of 1 to 4 carbon atoms), or R5 and R6, together with each other, are straight alkylene of 2 to 5 carbon atoms, or R7 and R8, together with each other, are straight alkylene of 2 to 5 carbon atoms, and R9 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl-(alkyl of 1 to 6 carbon atoms), AND NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS ANTIARRHYTHMICS. (From US4031219 A) [FR2319358A1]
Patent IE-841785-L (IE)
Title: Electrostatic spraying of liquids
IPC: B05D1/04
Filed: 1984-07-11
Abstract: 1. Process for the large-area application and distribution of electrically conductive liquids having a specific resistance of < 10**4 OMEGA . m, in which a high voltage is applied to the liquid, characterised in that the liquid is allowed to issue from a nozzle or capillary at such a low rate of flow that, immediately downstream of the nozzle or capillary, it forms a cohesive filament of liquid which then disintegrates into individual drops and in that, by means of the high voltage relative to earth which is applied to the filament of liquid, the drop size is stabilised and a conical distribution of drops (cone of drops) is produced whose apex angle depends on the level of the voltage.