Patent SG-11201901226R-A (SG)
Title: Peptides with vasodilatory and/or diuretic functions
Inventor: KINI MANJUNATHA RAMACHANDRA
IPC: C07K14/58
Filed: 2017-08-18
Abstract: CONTROL ANP. 1 2 0 Ir * DRD — 0 - -81,- ORD' FIG. 8C FIG. 8D FIG. 8A 100 FIG. 8B 10 - Tirne Imirt) 0.2 me<g/min 2.0 nnraVkginlin ; 4' E E O a -15 -20 min) 93 O co O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIPO I PCT 0111111010 0111 °nolo Oil OII 1111101 ois (10) International Publication Number WO 2018/034622 Al (51) International Patent Classification: C07K 14/58 (2006.01) A61P 9/00 (2006.01) A61K 38/22 (2006.01) (21) International Application Number: PCT/SG2017/050411 (22) International Filing Date: 18 August 2017 (18.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201606879W 18 August 2016 (18.08.2016) SG (71) Applicant: NATIONAL UNIVERSITY OF SINGA- PORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: KINI, Manjunatha Ramachandra; c/o Na- tional University of Singapore, Faculty of Science / De- partment of Biological Sciences, 21 Lower Kent Ridge Road, Singapore 119077 (SG). SRIDHARAN, Sindhuja; 32, Thambiah Road, Chennai 600033 (IN). (74) Agent: MATTEUCCI, Gianfranco; Marks & Clerk Sin- gapore LLP, Tanjong Pagar, P 0 Box 636, Singapore 910816 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: PEPTIDES WITH VASODILATORY AND/OR DIURETIC FUNCTIONS (57) : The present invention relates to peptides with vasodilatory and/or diuretic functions. In particular, the invention relates to modifying key amino acid residues in natriuretic peptides to achieve different functions and properties. Accordingly the invention also includes modified natriuretic peptides. The invention also relates to the use of these peptides for regulating blood pressure-volume and/or treating a heart condition. [Continued on next page] WO 2018/034622 Al MIDEDIMOMMIDIRE10111111001finfiliNVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))