baber/WOPTO huggingface dataset:
Patent CZ-300737-B6 (CZ)
Title: Antibody molecule specific for human TNF-alpha, compound containing antibody molecule, DNA sequence, cloning or expression vector, host cell, method for the preparation of antibody molecule, therapeutic or diagnostic composition and use of antibody m
Inventor: ATHWAL DILJEET SINGH
IPC: C12N15/09
Filed: 2001-06-05
Abstract: In the present invention, there is disclosed an antibody molecule specific for human TNF-{alpha} containing light chain and heavy chain, wherein this light chain comprises variable light chain region hTNF40-gLl (SEQ ID NO 8) and the heavy chain comprises variable heavy chain region gh3hTNF40.4 (SEQ ID NO 11), and method for the preparation thereof. There is also disclosed a compound containing this antibody molecule, which compound comprises a light chain formed of a sequence hereby denoted as SEQ ID NO 113 and a heavy chain formed of a sequence hereby denoted as SEQ ID NO 115, having bonded at one of their cysteine residues at C-terminal end of heavy chain a group derived from lysyl-maleinimide group, where each of the two amino groups of the lysyl residues has a covalently linked methoxypoly(ethyleneglycol) residue having a molecular weight of about 20,000 Da, each in lysyl amino group, whereas the whole molecular weight of the methoxypoly(ethyleneglycol) residues is about 40,000 Da. Further disclosed is a DNA sequence encoding heavy and/or light antibody molecule chain, a cloning or expression vector and a host cell transformed by this vector. Also disclosed is a therapeutic or diagnostic composition and as well as the use of the above-indicated antibody molecule for treating rheumatoid arthritis, osteoarthritis, Crohn's disease or psoriasis.
Patent CZ-302465-B6 (CZ)
Title: Mixtures for producing thermally insulating shaped bricks from expanded mineral materials and process for producing thereof
Inventor: CVANDA MILAN
IPC: C04B14/18
Filed: 2004-03-03
Abstract: The mixtures for producing thermally insulating shaped bricks for temperature range of 700 degC to 1200 degC, according to the present invention, comprise expanded ceramic materials in an amount of up to 75 percent by weight, with addition of crushed ceramic additives such as fireclay, white ware or schistous clay in an amount of 0.01 to 35 percent by weight, hydraulic binder in an amount of 0.01 to 35 percent by weight and aluminium oxide in an amount of 0.01 to 10 percent by weight. Prior molding, the mixture is moistened by the addition of up to 20 percent by weight of water, standardized by the addition of crushed ceramic additives and molded in a device comprising a mold (1) with at least one through hole (4), wherein in each hole upper and lower punches (2, 3) being brought into opposite motion relative to each another by a lower and upper hydraulic cylinder (11, 12) move vertically. At the mold (1) upper level, there is arranged a support plate (9) with a filling frame (8).
Patent CZ-300462-B6 (CZ)
Title: Method of measuring response time in animals, particularly in horses and system for measuring such time
Inventor: KUKACKA VLADISLAV
IPC: A61B5/16
Filed: 2006-09-25
Abstract: The present invention relates to a method of measuring response time in animals, particularly in horses (1) wherein the measuring method consists in that an animal is exposed to unexpected sound or sound-visual stimulus, at best an air ball (3) blow out. Stimulus initialization and following muscular and/or motional horse (1) response are recorded by a high-speed camera (2). The response time is read off by stepping as a sum of single time intervals between the high-speed camera (2) shots from stimulus initialization to visible muscular and/or motional horse (1) response. Measuring is performed in calm condition or after the horse (1) previous physical strain. There is also disclosed a system for measuring response time in animals wherein such system comprises a device for producing unexpected supraliminal sound or sound-visual stimulus and the above-indicated high-speed camera (2).
Patent CZ-302453-B6 (CZ)
Title: Process for preparing hydrogen and other products and apparatus for making the same
Inventor: MOUREK LUKAS
IPC: C01F7/428
Filed: 2010-04-07
Abstract: According to the present invention, hydrogen is prepared from waste aluminium by reacting thereof with water in the presence of sodium hydroxide as a catalyst. In addition to hydrogen, other reaction products are also aluminium hydroxide, sodium chloride and heat, optionally electric power. The reaction takes place within a reactor (1) and hydrogen accumulates in a low-pressure hydrogen tank (3). The hydrogen preparation process of the present invention is characterized in that gas is gradually exhausted by means of a vacuum pump (4) from the reactor (1) and other auxiliary equipment to a pressure value of at least 0.5 kPa, subsequently the reactor (1) and other auxiliary equipment are filled with hydrogen with purity of 99.5 percent and again gas is gradually exhausted therefrom. Then they are again filled with hydrogen with purity at least 99.5 percent to overpressure of at least 0.1 MPa. Gas exhausted from the reactor and other equipment is drawn off by said vacuum pump (4) into a chimney (5) wherefrom it is discharged to atmosphere. The invention relates to a process and apparatus for safe industrial production of hydrogen and other products, as well as for purification thereof such as to make them suitably usable in industry as starting materials for further production.
Patent CZ-304329-B6 (CZ)
Title: Validation bucket elevator for modeling mechanical processes and method of modeling mechanical processes
Inventor: GELNAR DANIEL
IPC: B65G43/08
Filed: 2013-04-25
Abstract: The present invention relates to determination of influence of bulk (particulate) material properties upon functionality of transportation. It resolves execution of checking and simulation experiments, particularly simulation of transportation processes on a bucket elevator, simulation of current and speed fields, interactions between structural elements and transported materials having impact on transportation by bucket elevators. The method DEM (Discreet Element Method) is used in the invention for projecting new bucket elevators. Based on measured values of the physical and mechanical properties of the actual material there is performed by programming in the DEM application an actual mixture for dynamic simulation. The optimization parameters required are obtained by measuring on physical models of the actual bucket elevators. It is possible to scan, evaluate and optimize a wide range of data such as particle speed, structure torque, temperature, pressure, moisture, Poisson’s ratio, size and shape of the particles, etc. Values, obtained from the actual measuring and simulation are then compared and based thereon the attendance can do an optional change in transportation parameters. The measured values are archived and can be therefore any time used for optimization of the existing bucket elevators or for projecting new ones.
Patent CZ-305738-B6 (CZ)
Title: Substituted derivative of phosphorus oxyacids, use thereof and pharmaceutical composition containing it
Inventor: VINŠOVÁ JARMILA
IPC: C07F9/6584
Filed: 2014-12-16
Abstract: The present invention relates to a antituberculosis active substances based on phosphorus oxyacid derivatives with substituted salicylanilides of the general formula I, in which Re1, Re2 = a hydrogen atom, a halogen atom or NOi2; Re3, Re4 = a hydrogen atom, a halogen atom or NOi2, or CFi3; Re5 = H, halogen, or NOi2; Re6 = alkyl containing 2 to 16 carbon atoms, aryl having 6 to 18 carbon atoms, aryloxy containing 6 to 18 carbon atoms, or arylalkyloxy having 6 to 18 carbon atoms in the aryl moiety and 2 to 16 carbon atoms in the alkyloxy moiety; Re7 = aryl containing 6 to 18 carbon atoms, aryloxy having 6 to 18 carbon atoms, arylalkyloxy having 6 to 18 carbon atoms in the aryl moiety and 2 to 16 carbon atoms in the alkyloxy moiety or it is omitted; Re8 = a hydrogen atom or a dingle bond to phosphorus. These compounds, which can be prepared by simple syntheses, exhibit high activity against mycobacteria including multiresistant strains thereof. The invention also discloses the use of that type of phosphorus oxyacid aromatic derivatives and salicylanilides of the general formula I as antituberculosis agents and/or antimycobacterial medicaments. Further, the invention also discloses a pharmaceutical composition in which the derivative of the general formula I is comprised as an active substance.
Patent CZ-308393-B6 (CZ)
Title: Equipment for chain locking
Inventor: Mrázek Jiří
IPC: F16H55/30
Filed: 2018-06-25
Abstract: A toothed device for snapping into a chain (5) with at least two teeth (2) adapted to the fixed pitch (P) of the chain (5) selected from the group consisting of a rack, a toothed belt and a toothed chain, where the teeth (2) have a fixed stop (3) with a clearance (Δ) and a resilient surface with a second stop (4) defined by another clearance (Δ2).
Patent CZ-298746-B6 (CZ)
Title: Derivatives of 2-pyridylmethylamine, process of their preparation and fungicidal agent in which the derivatives are comprised
Inventor: MOLONEY BRIAN ANTHONY
IPC: C07D213/61
Filed: 1999-02-16
Abstract: In the present invention, there are disclosed 2-pyridylmethylamine derivatives of the general formula I and salts thereof as phytopathogenic fungicides wherein Ae1 is a substituted 2-pyridyl group; Ae2 is an optionally substituted phenyl group; L is -(C=O)-, -SOi2- or -(C=S)-; Re1 and Re2 represent a hydrogen atom. There is also disclosed a process for preparing the above-described derivatives and a fungicidal composition in which these derivatives are comprised.
Patent CZ-304941-B6 (CZ)
Title: Composition comprising antigen for sublingual administration to produce mucosal and systemic immune response
Inventor: WHEELER ALAN
IPC: C12N15/63
Filed: 2001-01-15
Abstract: In the present invention, there is disclosed the use of a composition containing at least one antigen and a glycolipid adjuvant for the preparation of a medicament intended for sublingual administration for providing a mucosal and systemic immune response and the use thereof for the preparation of a medicament intended for the treatment or prevention or reduction susceptibility to bacterial infection, viral prion infection, autoimmunity, cancer, mucosally transmitted disease or allergy in a human or animal.
Patent CZ-296958-B6 (CZ)
Title: Pressing cushion
Inventor: HALTERBECK WALTER
IPC: B30B15/06
Filed: 2002-09-25
Abstract: In the present invention, there is disclosed a pressing cushion (1) intended for use in laminating presses, having a textile support (2) with threads (3, 4, 5), at least some of which constitute thermally conductive threads (3, 4, 5) that bring about, either directly or by contact with other thermally conductive threads (3, 4, 5), a thermal transfer from one outer side to the other outer side of the pressing cushion (1), the support (2) comprising a cushion layer (7) made of a flexible rubber material, wherein the thickness of the cushion layer (7) is less than that of the support (2), and the cushion layer (7) is embedded into the support (2) in such a way that thermally conductive threads (4, 5) protrude beyond the cushion layer (7) on both outer sides of the pressing cushion (1).
Patent SK-288928-B6 (SK)
Title: Composit material for implants, its use and the method of its production
Inventor: BALOG MARTIN
IPC: A61L27/58
Filed: 2016-07-13
Abstract: The composite material comprises a biocompatible titanium (Ti) or biocompatible Ti alloy, and biodegradable component, which is intended to at least partially desorb in vivo in contact with human tissue and which has an Young's elastic modulus lower than used Ti or Ti alloy. The material is prepared from a mixture of the particles of Ti or Ti alloy and the particles of the biodegradable component, wherein the biodegradable component, in particular magnesium (Mg), is dispersed throughout a volume of the material and occupies 2 to 20 volumic % in the material. The biodegradable component is present in a bearing Ti or Ti alloy structure in the form of filaments oriented along an extrusion axis. A manufacturing process comprises fabrication of powders, mechanical blending of powders to a homogeneous mixture and a subsequent extrusion at a temperature from 300 °C to 640 °C. The components are consolidated to a common mass, wherein during a consolidation the biodegradable component is formed into filaments oriented along an extrusion direction. Prior heated and extrusion the powder mixture may be precompacted in order to reach acceptable handling strength and cohesion.
Patent SK-288474-B6 (SK)
Title: Trigger mechanism for auto-loading weapon, and auto-loading manual weapon
Inventor: KURACINA JAROSLAV
IPC: F41A19/48
Filed: 2014-09-18
Abstract: The trigger mechanism of the auto-loading weapon enabling to select a suitable shooting operation by a single control element, which shooting operation is either single action/double action operation (SA/DA) with the safe hammer (7) activation having the possibility to lock the cocked hammer, or the exclusive double action operation (DAO). The trigger mechanism consist of the swivel (23), the main catcher (9.1 ) of the hammer and the auxiliary catcher (9.2) of the hammer, equipped with the means for the mutual collaboration and for the collaboration with the hammer (7), wherein the swivel (23) is placed in revolving and adjustable position, and it is controlled by the control element (22) on the weapon surface.
Patent EP-1200493-B8 (EP)
Title: Resines c5 d'hydrocarbures modifiees, aromatiques, legerement colorees
Inventor: DONKER CHRETIEN P L C
IPC: C08L9/00
Filed: 2001-01-11
Granted: 2007-08-08
Abstract: L'invention porte sur des résines C5 d'hydrocarbures, modifiées, aromatiques, légèrement colorées. Ces résines sont principalement des résines de pipérylène modifiées, aromatiques. Elles sont utiles comme agents collants dans les adhésifs thermofusibles et les adhésifs autocollants.
Patent EP-1846660-B8 (EP)
Inventor: METZGER MICHAEL
IPC: F04D27/02
Filed: 2006-02-02
Granted: 2009-11-11
Abstract: In a method for controlling a compression installation (1), the installation has at least two compressor units (i=1, , N) that can be separately turned on or off, a plurality of devices for modifying the output of the compressor units and a control device (10). Known methods and devices do not function optimally in terms of the power consumption of the entire compression installation. The power consumption (EG) for the operation of a plurality of compressor units (i=1, , N) of a compression installation (1) can be optimized by calculating a novel circuit configuration (Si, t) and automatically adjusting the novel circuit configuration (Si, t) by a control device (10).
Patent EP-2041297-B8 (EP)
Inventor: ANTONINI GIOVANNI
IPC: C12Q1/04
Filed: 2007-07-10
Granted: 2012-02-29
Abstract: A method for detecting a bacterial load comprising adding a sample for analysis to an analysis reagent in a sterilized reaction container, thermostatting the reaction container at a temperature of between 25 and 45° C., and verifying the change in colouring of the analysis reagent. The analysis reagent is an aqueous solution comprising amino acids chosen from the group consisting of meat peptones, vegetable peptones, casein hydrolysates, tryptose, tryptones and yeast extract; glucides chosen from monometric or oligomeric glucides metabolisable by micro-organisms; a buffer system suitable for maintaining the pH between 5.5 and 8.5; a redox indicator with potential between −250 and +250 mV and/or a pH indicator with colour change interval between pH 4.0 and pH 9.0; and a water-immiscible organic liquid compound having a lower density than water and suitable for separating the aqueous phase from a gaseous phase existing prior to the analysis or formed during the reaction.
Patent EP-0528686-B8 (EP)
Inventor: YABUTA MASAYUKI
IPC: C12N15/62
Filed: 1992-08-19
Granted: 2004-01-14
Abstract: A process for production of a peptide (target peptide) comprising:     A) culturing host cells transformed with a plasmid able to express a gene coding for a fusion protein represented in the following formula: A-L-B wherein, B is a target peptide, A is a protective peptide comprised of 90-200 amino acid residues, and L is a linker peptide positioned between the C-terminal of said protective peptide and the N-terminal of said target peptide and selected so that said fusion protein is treated by an enzyme or chemical substance, the above-mentioned target peptide is separated, and said protective peptide and linker peptide are selected so that the isoelectric point of the entire fusion protein A-L-B is within a range of 4.9-6.9; B) obtaining an insoluble fraction comprising inclusion bodies by homogenization of the cultured cells of said transformant body; C) solubilizing of a fusion protein in said inclusion bodies by treatment of said insoluble fraction with solubilizing agent; and, D) cleaving of the peptide bond between the C-terminal of the linker amino acid residue and the N-terminal of the target peptide of said solubilized fusion protein to release said target peptide from the other peptides followed by purification of said target peptide.   The present invention is able to express a target peptide in a large amount and accumulate said target peptide in host cells in the form of inclusion bodies.
Patent BR-PI0600256-B8 (BR)
Inventor: DOUGLAS B HOFFMAN
IPC: A61B17/072
Filed: 2006-02-07
Abstract: A surgical stapling and severing instrument particularly suited to endoscopic procedures incorporates a handle that produces separate closing and firing motions to actuate an end effector. In particular, the handle produces multiple firing strokes in order to reduce the required amount of force required to fire (i.e., staple and sever) the end effector. A linked transmission reduces the required handle longitudinal length, yet achieves a rigid, strong configuration when straightened for firing. A traction biased firing mechanism avoids binding in driving this straightened linked rack in cooperation with an anti-backup mechanism, with a lockout mechanism that prevents releasing the closure trigger during firing. Furthermore, an external indicator gives feedback to the surgeon as to how far firing has progressed, as well as providing a manual retraction capability.
Patent BR-PI0618441-B8 (BR)
Title: vetor adenoviral
Inventor: C RICHTER KING
IPC: C12N15/861
Filed: 2006-11-13
Abstract: vetor adenoviral e método de indução de uma resposta imune contra um aftovírus em um mamífero. a invenção é dirigida a um vetor adenoviral que compreende pelo menos uma seqúência de ácidos nucléicos que codifica um antígeno de aftovírus e/ou uma citocina ligada operacionalmente a um promotor. o vetor adenoviral possui replicação deficiente e exige, no máximo, complementação tanto da região e1 quanto da região e4 do genoma adenovira]. para propagação. a invenção também é dirigida a um método de indução de uma resposta imunolágica em um mamífero que compreende a administração ao mamífero de uma composição que compreende o vetor adenoviral mencionado anteriormente.
Patent BR-PI0719159-B8 (BR)
Title: dispositivo anti-intrusão para cartão eletrônico.
Inventor: ERIC DUBOIS
IPC: G06F21/87
Filed: 2007-10-02
Abstract: dispositivo anti-intrusão para cartão eletrônico a invenção se refere a um dispositivo anti-intrusão para cartão eletrônico que compreende um circuito flexível (2) que compreende uma pista eletricamente condutora (21) em forma de treliça ligada a meios de tratamento do cartão eletrônico, uma guia (3) em tomo da qual o circuito flexível (2) é disposto em tomo e que permite manter o circuito flexível (2) na posição, e uma capa ( 4) de proteção disposta em tomo do conjunto constituído pela guia (3) e pelo circuito flexível (2), o dispositivo anti-intrusão sendo destinado a ser disposto em uma região do cartão eletrônico a proteger.
Patent AU-2001280702-B8 (AU)
Title: Compounds and methods for treatment and diagnosis of chlamydial infection
Inventor: SKEIKY YASIR A W
IPC: A61K48/00
Filed: 2001-07-20
Granted: 2008-02-28
Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
Patent AU-2003301414-B8 (AU)
Title: Novel compounds with antibacterial activity
Inventor: HUBSCHWERLEN CHRISTIAN
IPC: C07D451/04
Filed: 2003-10-09
Granted: 2010-06-17
Abstract: 4-substituted quinoline derivatives (I), their salts, solvates, hydrates and formulations are new. 4-substituted quinoline derivatives of formula (I), their salts, solvates, hydrates and formulations are new. [Image] A : oxygen, sulfur, nitrogen, 1-4C (hetero)alkylene or 2-4C alkenylene or alkynylene; X 1-X 5nitrogen or CR 2>; R 1>hydrogen, hydroxy or (hetero)alkoxy; R 2>hydrogen, halo, hydroxy, (hetero)alkyl, alkenyl or alkynyl; R 3>a group of formula (i)-(viii); R 4>hydroxy, 1-6C alkyl or 1-8C heteroalkyl; R 5>(hetero)alkyl, alkenyl, alkynyl, (hetero)aryl, (alkyl)cycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl; n : 0-3; and m : 0 or 2. [Image] ACTIVITY : Antibacterial. 2-((3RS)-{[(2,3-dihydrobenzo[1,4]dioxon-6-ylmethyl)amino]methyl} piperidin-1-yl)-(1RS)-(6-methoxyquinolin-4-yl)ethanol (Ia) had MIC below 0.5 Microg/ml against at least one of the strains Staphylococcus aureusATCC 29213 or I6; E. faecalisATCC 29212; E. faeciumvanA E25-1; Haemophilus influenzae11; Escherichia coliATCC 25922; M. catarrhalisand Streptococcus pneumoniaeATCC 49619. MECHANISM OF ACTION : None given.
Patent AU-2010233759-B8 (AU)
Title: Wagering game with multi-level progressive jackpot with partial reset
Inventor: JAFFE JOEL R
IPC: A63F13/00
Filed: 2010-10-14
Granted: 2013-02-21
Abstract: A gaming system and method for conducting a wagering game includes a bonus feature that awards percentages of a progressive jackpot award without resetting the progressive jackpot award. A wager input receives a wager from a player to play a single play of a wagering game. The wagering increases the progressive jackpot award. A bonus feature is triggered that includes awarding a first award that has an amount that is a percentage less than 100% of the progressive jackpot award. The bonus feature may also award a second award that is at least the entire progressive jackpot award. If the first award is awarded, the progressive jackpot award remains at the same level. If the second award is awarded, the progressive jackpot award is reset to a predetermined minimum value. 10 s SYSTEM(S) 46 50 MECHANISM 14 PRIMARY E RA 14SPRA MAAREA - SYSTEMS 58 48 MONEY /CREDIT 24 INFORMATION READERS) 26 PLAYER-INPUT 56 52 TICKET PRINTER 18 SPEAKERS DIPLAYE -4 28 ACCESSIBLE INFORFAG.O2
Patent AU-2010341421-B8 (AU)
Title: Collection device and material
Inventor: YONG TERRY
IPC: B31B50/62
Filed: 2010-08-03
Granted: 2013-10-24
Abstract: Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers.
Patent BR-122013008865-B8 (BR)
Title: adenovírus oncolítico de replicação competente
Inventor: IRENE KUHN
IPC: C12N15/861
Filed: 2005-05-24
Abstract: adenovírus oncolítico de replicação competente. a presente invenção se refere a adenovírus oncolíticos de replicação competente do sotoripo 11 tendo aplicações terapêuticas.