Patent SG-11201903892U-A (SG)
Title: [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
Inventor: VAN ROOSBROECK YVES
IPC: C07D519/00
Filed: 2017-10-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111411 0 11101 HOE 3E1 0 0111111111111001101H 110 11110 III 011 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2018/083098 Al 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: Turnhoutseweg 30, 2340 Beerse (BE). GIJSEN, Henri- CO7D 487/04 (2006.01) A61K 31/519 (2006.01) cus, Jacobus, Maria; Janssen Pharmaceutica NV, Turn- CO7D 519/00 (2006.01) A61P 25/00 (2006.01) houtseweg 30, 2340 Beerse (BE). AHNAOU, Abdel- (21) International Application Number: lah; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). DRINKENBURG, Wilhelmus, Helena, Ig- PCT/EP2017/077910 natius, Maria; Janssen Pharmaceutica NV, Turnhoutseweg (22) International Filing Date: 30, 2340 Beerse (BE). 31 October 2017 (31.10.2017) (74) Agent: QUAGHEBEUR, Luc; Johnson & Johnson, Patent (25) Filing Language: English Law Department, Turnhoutseweg 30, 2340 Beerse (BE). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 16196924.1 02 November 2016 (02.11.2016) EP CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicant: JANSSEN PHARMACEUTICA NV DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, [BE/BE]; Turnhoutseweg 30, 2340 Beerse (BE). HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (72) Inventors: VAN ROOSBROECK, Yves, Emiel, Maria; MG, MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Beerse (BE). VAN DEN KEYBUS, Frans, Alfons, Maria; SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, — Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ Beerse (BE). TRESADERN, Gary, John; c/o: Janssen- Cilag, S.A., Edificio Johnson & Johnson, Paseo de las (84) Designated States (unless otherwise indicated, for every = Doce Estrellas, 5-7, 5° planta, Campo de las Naciones kind of regional protection available): ARIPO (BW, GH, 28042 Madrid (ES). BUIJNSTERS, Peter, Jacobus, Jo- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = hannes, Antonius; Janssen Pharmaceutica NV, Turnhout- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, seweg 30, 2340 Beerse (BE). VELTER, Adriana, In- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, grid; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Beerse (BE). JACOBY, Edgar; Janssen Pharmaceuti- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, — = = = ca NV, Turnhoutseweg 30, 2340 Beerse (BE). MAC- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, DONALD, Gregor, James; Janssen Pharmaceutica NV, KM, ML, MR, NE, SN, TD, TG). = Title: [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS (54) = = _ N N,._ ,R A = — _ / -- - 1.\" --. \`,\"'\" % ..- N .... ,,.7 . = I B R (I) = = R1 R 2 . . = 0 .... ,IV. 1 Il R 3 R 3 R 3 GC (a), (b), (c), 01 0 M X ) (57) : The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-y1 derivatives as inhibitors of phosphodiesterase 0 —. 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such GC compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in 1-1 © which PDE2 is involved, such as neurological and psychiatric disorders. ei C [Continued on next page] WO 2018/083098 Al MIDEDIMOMMIDIREIERIMMIRIMEHMEMOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply patent (Rule 4.17(11)) for and be granted a Published: — with international search report (Art. 21(3))