baber/WOPTO huggingface dataset:
Patent CA-2043604-A1 (CA)
Title: Pyridinylpiperazine derivatives
Inventor: CARLIER PATRICK
IPC: A61K31/4402
Filed: 1991-05-30
Abstract: ABSTRACT            Disclosed are compounds displaying improved preferential serotonin-1A binding activity.   The claimed compounds have the formula:                         wherein R1 is selected from the group consisting of hydroxy, halogen, lower alkyl, lower alkoxy, and hydrogen; R2 is hydrogen or lower alkyl; X is CH or a nitrogen atom; ALK is a saturated, branched or unbranched,  aliphatic hydrocarbon having from 1 to 7 carbon atoms; and Z is selected from the group  consisting of hydrogen, halogen, hydroxy, trifluoromethyl, or lower alkyl; or a pharmaceutically acceptable salt thereof.
Patent CA-2043819-A1 (CA)
Inventor: JONES EDWARD M JR
IPC: B01D3/20
Filed: 1991-06-04
Abstract: ABSTRACT OF THE DISCLOSURE    To achieve good liquid-vapor contact and at the same time better utilize the heat of reaction in a distillation column reactor  a  system  is  provided  wherein  a  reaction  tray  and distillation tray are  "coupled"  by a continuous liquid level between the two.   A reaction tray,  containing the appropriate catalyst,  is situated directly below a distillation tray.   A vapor riser is provided through the reaction tray as a by-pass which carries the vapor from a lower distillation tray to a vapor distribution area underneath the  "coupled"  distillation tray.          Liquid  flows  downward  through  a  downcomer  by-passing  the "coupled" distillation tray,  and onto and across the "coupled" reaction tray immersing the catalyst and rises upward, onto and across the "coupled" distillation tray where it is intimately contacted  with  the  rising  vapor  effecting  fractional distillation.   Only that vapor produced by the reaction on the reaction tray rises through the catalyst minimizing movement and pressure  drop  while  the  heat produced  contributes  to  the distillation.   A sufficient vertical distance between the two "coupled"  trays  is  provided  to  allow  disengagement  of  any catalyst particles which might become entrained in the rising liquid. A screen,  if necessary, may also he positioned in the space between the distillation tray and the reaction tray to retain the particulate catalyst below the distillation tray.     \crl .pat\1230.app
Patent CA-2048993-A1 (CA)
Title: Molecular cloning of genomic and cdna sequences encoding cellular receptors for poliovirus
Inventor: RACANIELLO VINCENT
IPC: C07K14/00
Filed: 1990-03-09
Abstract: The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for picornavirus and in addition, provides a purified polypeptide which has this activity. The subject invention also provides a method for inducing the production of a polypeptide which includes the use of expression vectors in a host vector system. Therapeutic compositions comprising purified polypeptides which have the biological activity of a receptor for picornavirus are also provided for as are methods of treating and preventing human poliovirus infection. Further, the subject invention provides a method of producing a transgenic animal expressing human picornavirus. The subject invention provides a method of testing the efficacy of a picornavirus vaccine which comprises administering the vaccine to a transgenic animal described above and determining whether the resulting transgenic animal is protected from infection by human picornavirus. Lastly, a method of testing the virulence of a picornavirus vaccine is provided.
Patent CA-2049100-A1 (CA)
Title: Benzoic acid phenylester compounds and elastase inhibiting compositions containing the same
Inventor: YAMADA HIROHIKO
IPC: C07C275/42
Filed: 1991-09-09
Abstract: ABSTRACT OF THE DISCLOSURE        A benzoic acid phenylester compound having a substituted amino group at position 4 according to the following formula [I], which has inhibitory activity against human leucocyte elastase of a protease, and elastase inhibiting compositions containing the same as active ingredients are disclosed.                         [I]
Patent CA-2055018-A1 (CA)
Title: Firing target
Inventor: BERGER-KUHL JOACHIM
IPC: F41J1/01
Filed: 1991-11-06
Abstract: IFT GmbH                                     899/001 EP                    Abstract The firing target 1 is intended in particular for military firing practices and is distinguished by the fact that it is made from a polyethylene mixture. The mixture is preferably made up of HDPE and LDPE, there being 80% HDPE and 20% LDPE.        In comparison with conventional firing targets of multi-layered plywood, this target 1 permits much higher numbers of shots. This is attributable to the fact that the penetration channel 10 has a distinctly reduced exit opening in relation to the entry opening (which cor-responds to the projectile calibre K),  the said exit opening in some cases even being completely closed again.            (Fig. 2)
Patent CA-2059640-A1 (CA)
Title: Method and apparatus for measuring characteristics of a multilayer product
Inventor: DUKES JOHN R
IPC: G01N23/16
Filed: 1990-08-13
Abstract: A method and apparatus are disclosed wherein a plurality of basis weight sensors (120, 122, 124, 126, 128) are interleaved with one or more processing stations (104, 106, 108) used to conjoin or apply one or more layers (112, 116) to a base substrate (102) to form a multilayer product (118, 110) such that a sensor (120, 122, 124, 126, 128) is located on the input and output sides of each processing station (104, 106, 108). Each of the sensors (120, 122, 124, 126, 128) can be calibrated with a plurality of product calibrations such that multiple output signals corresponding to multiple products can be generated simultaneously by the sensors.  Each of the sensors (120, 122, 124, 126, 128) is calibrated with product calibrations corresponding to the product (118, 110) or intermediate stage (114) of the product (118) which it monitors, the layer applied by the processing station preceding it, if any, and the layer applied by the processing station succeeding it, if any. Signals generated by the sensors (120, 122, 124, 126, 128) may then be used directly to determine the basis weight of the resulting product (118) and/or each intermediate stage (114) of the product, or the signals may be processed to determine the basis weight of each layer of material of the resulting product independent of the substrate (102) to which the layer was applied.  Substrate independent layer measurement is performed by subtracting the output signal generated by the sensor preceding the processing station applying the layer based on the product calibration corresponding to the layer from the output signal generated by the sensor succeeding the processing station applying the layer based on the product calibration corresponding to the layer.
Patent CA-2059951-A1 (CA)
Inventor: WADE RICHARD B
IPC: F16L37/42
Filed: 1992-01-23
Abstract: A quick disconnect coupler includes a seal retaining member movably mounted in a coupler housing. A sealing washer biases the retaining member toward first position, and an annular seal is mounted in the retaining member.  This annular seal defines both axial and radial sealing surfaces, and it is configured to transmit sufficient force to the seal retaining member to move the seal retaining member to a rearward position in response to a first, larger diameter plug bearing on the axial sealing surface, and to form a radial seal around a second, smaller diameter plug.
Patent CA-2061355-A1 (CA)
Inventor: SEBASTIAN PETER R
IPC: A61F13/14
Filed: 1992-02-17
Abstract: A therapeutic appliance is securable in an operative orientation around the abdominal region of the body for therapeutically treating the lumbar area and upper portion of the sacrum.  The appliance includes an external shell securable about the abdominal region of the body and pouches repositionably attached to the shell for accommodating various types of therapeutic pads.  Each of the pouches may be moved or pivoted between a position at which the pad accommodated therein will overlie the lumbodorsal fascia and quadratus lumborum muscles and a second position at which the pad will overlie the erector spinae muscles. In addition, a band-like elastic member is secured to the shell in a manner in which the elastic member may exert tension over the pouches.  Opposite ends of the elastic member can be secured at various locations along opposite ends of the external shell so that the tension of the elastic member can be varied.  Further, releasable suspender straps are provided to maximize comfort and to minimize the likelihood of user injury caused by snagging of the suspender straps.
Patent CA-2062294-A1 (CA)
Title: Thin film of oxide superconductor possessing locally different crystal orientations and processes for preparing the same
Inventor: INADA HIROSHI
IPC: H01L39/24
Filed: 1992-03-04
Abstract: A thin film of oxide superconductor consisting of more than two portions (10; 11, 12) each possessing a predetermined crystal orientation and deposited on a common surface of a substrate (2). At least one selected portion (10) of the thin film of oxide superconductor is deposited on a thin under-layer (4, 100) which facilitates crystal growth of the selected portion and which is deposited previously on the substrate.     The selected portions (10) may consist of a-axis oriented thin film portions while non-selected portions (11, 12) may consists of c-axis oriented thin film portions. The thin under-layer can be a buffer layer (4) or a very thin film (100) of oxide superconductor.
Patent CA-2065346-A1 (CA)
Title: Tumor necrosis factor-.alpha. and-.beta. receptors
Inventor: SMITH CRAIG A
IPC: C07K14/715
Filed: 1990-07-17
Abstract: Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
Patent CA-2066173-A1 (CA)
Title: Interactive medication delivery system
Inventor: KAUFMAN STEPHEN B
IPC: G06F19/00
Filed: 1990-09-28
Abstract: A medication delivery device (10) includes a housing (12) containing separate first and second storage locations (40, 42) for holding medication dosages away from access by the user. Associated separate first and second delivery mechanisms (46, 48) permit selective delivery of medication dose from either the first or second storage locations to the patient. The invention provides a control element (50) that discriminates between the actuation of the first delivery mechanism and the second delivery mechanism, thereby discriminating between the delivery of medication housed in the first and second storage locations. The control element discriminates between different first and second input criteria. In response to the first input criteria but not in response to the second input criteria, the control element actuates the first delivery mechanism. In response to the second input criteria, the control element actuates the second delivery mechanism.
Patent CA-2068527-A1 (CA)
Title: Muscarinic receptor antagonists
Inventor: ALKER DAVID
IPC: C07D405/06
Filed: 1991-09-09
Abstract: Muscarinic receptor antagonists, useful especially in the treatment of irritable bowel syndrome, of formula (IA) or (IB) or a pharmaceutically acceptable salt thereof, where R2 and R3 are each independently H,halo or C1-C4 alkyl; m is 0, 1 or 2 ; n is 1, 2 or 3; Y is a direct link, O or S; with the proviso that when n is 1, Y is a direct link; Het is a group of formula (A) or (B), where p is 0, 1 or 2, q is 1, 2 or 3, and r is 0, 1, 2 or 3, with the proviso that the sum of p, q and r is at least 3, the N atom of "Het" being attached to the group (CH2)n in formula (IA) and to the H atom in formula (IB); and R1 is a group of formula (a), (b) or Het1, where R4 and R5 are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)tOH, halo, trifluoromethyl, cyano, -(CH2)tNR6R7, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2, -SO2NH2, -(CH2)tCONR6R7 or -(CH2)tCOO(C1-C4 alkyl); R6 and R7 are each independently H or C1-C4 alkyl; t is 0, 1 or 2; X and X1 are each independently O or CH2; s is 1, 2 or 3; and Het1 is pyridyl, pyrazinyl or thienyl.
Patent CA-2073666-A1 (CA)
Inventor: DURAN VINCENT
IPC: A47J37/04
Filed: 1992-07-10
Abstract: ABSTRACT OF THE DISCLOSURE An improved rotisserie grill is provided and consists of an elongated rectangular framework having four vertical legs, one in each corner and two side cross members, each extending horizontally between two legs A rotatable spit is supported longitudinally above the framework An electric motor is supported on the framework to rotate the spit. A semi-cylindrical fire bowl having a curved inner surface is affixed to the framework with the side cross members supporting the bottom ends of the fire bowl. A grate is carried in the fire bowl to hold fuel thereon so that when the fuel is burned the curved inner surface of the fire bowl will reflect heat towards the rotating spit.
Patent CA-2074509-A1 (CA)
Inventor: ABE KOJI
IPC: C08L101/02
Filed: 1991-11-28
Abstract: An antibacterial agent containing a polyelectrolyte complex prepared by the reaction of a cationic polymer containing N+ atoms in the repeating units with an anionic polymer containing -COO-, -SO3- or -PO3- groups in the repeating units; and an antibacterial material comprising the polyelectrolyte complex carried on a support.
Patent CA-2075372-A1 (CA)
Title: Process in thermal decomposing a carbonaceous raw material and reactor for carrying out the process
Inventor: NILSSON BENGT
IPC: C10J3/48
Filed: 1991-02-04
Abstract: A process in thermally decomposing a carbonaceous raw material in order to recover a gas having industrial value as fuel or starting material for the production of chemicals, and inorganic components in solid and/or molten form is described as well as a reactor for carrying out this process. The raw material is fed into a chamber in the reactor and the thermal decomposition is carried out at a pressure of from atmospheric pressure up to about 150 bar and at a temperature in the range of 500-1600 ·C. According to the invention the thermal decomposition is carried out during exposure to low frequency sound and without or with the supply of oxygen or a gas containing oxygen in an amount below that stoichiometrically required for complete combustion of the raw material.
Patent CA-2077819-A1 (CA)
Inventor: KANGA VISPI
IPC: A61K8/00
Filed: 1992-09-09
Abstract: A cosmetic oil and water emulsion is described whose essential components are a polyalphaolefin and a coupling solubilizing agent of the formula:          HO?(CH2CHRO)m(CH2)n(OCHRCH2)m'? OH wherein m and m' are integers greater than 1, n is an integer greater than 3; and R is selected from the group consisting of hydrogen, C1-C12 alkyl and mixtures thereof.
Patent CA-2078167-A1 (CA)
Title: Automatic course pilot in a ship provided with turnable propeller gears
Inventor: VIRTANEN MARKKU
IPC: B63H25/42
Filed: 1992-09-14
Abstract: Abstract The invention concerns an automatic course pilot in a ship provided with turnable propeller gears for automatic retaining of the course of the ship and for course steering in accordance with a preset course. In the ship the propeller gears (1, 2) are arranged as a pair symmetrically in relation to the centre line of the ship, and the propeller gears (1, 2) are connected to the central unit of the automatic steering, which is optionally connectable for controlling either one or both of the propeller gears (1, 2) that form a pair. When both of the propeller gears (1, 2) in a pair are switched on automatic course steering, the central unit of the automatic steering is arranged to shift the control devices of the propeller gears (1, 2) into an asymmetric state of operation. In such a case, when the automatic steering gives a command to turn, the control systems of the propeller gears (1, 2) are arranged automatically to select the propeller gear (1, 2) in each particular case placed at the side of the inside curve for the propeller gear that turns the ship so as to retain the torque that turns the ship.
Patent CA-2078973-A1 (CA)
Title: Multilayered catalyst for controlled transport of reactant
Inventor: MATTURRO MICHAEL G
IPC: B01D71/02
Filed: 1992-09-23
Abstract: ABSTRACT OF THE DISCLOSURE    The present invention is a multilayered catalyst structure coated onto the surface of a membrane which does not have physical micropores.  The non-microporous membrane serves as a mechanical support for the thin multilayered catalyst structure and also can be used to control the rate at which some reactants arrive at (or some produce leave from) the multilayered catalyst structure.       A multilayered catalyst structure is coated on the non-microporous membrane which is composed of at least a catalyst layer and a separate transport layer.
Patent CA-2079832-A1 (CA)
Inventor: GALVAN GUADALUPE L
IPC: B61D7/28
Filed: 1992-10-05
Abstract: One double acting cylinder is attached to the doors of a gate assembly via a linkage. A lock out system cooperates with the linkage whereby different parts of the linkage may be immobilized prior to the beginning of a work cycle. The work performed by the double acting cylinder thus passes through the free parts of the linkage to actuate one door ar the other.
Patent CA-2081144-A1 (CA)
Title: Thermoplastic resin composition
Inventor: NAGAOKA KENJI
IPC: C08K3/22
Filed: 1992-10-22
Abstract: ABSTRACT              THERMOPLASTIC RESIN COMPOSITION           A resin composition having improved resist-ance to discoloration by sunlight comprising (A) a polymer mixture which comprises a polyphenylene ether, a polyamide and optionally a polystyrene and/or an agent to improve the impact resistance, and (B) an inorganic powder whose mean particle size is less than or equql to 5 micrometer, in an amount of more than or equal to 15 parts by weight based on 100 parts by weight of the polyphenylene ether in the polymer mixture (A), which is selected from the group consisting of titanium oxide, mica coated with titanium oxide, barium sulphate, zinc oxide and zinc sulfide.
Patent CA-2081198-A1 (CA)
Title: Partial esters of epoxy containing compounds and related halogen containing polymer compositions
Inventor: HIRSHMAN JUSTIN L
IPC: C07C69/675
Filed: 1992-10-22
Abstract: PARTIAL ESTERS OF EPOXY CONTAINING COMPOUNDS AND RELATED HALOGEN CONTAINING POLYMER COMPOSITIONS            Abstract of the Invention The  present  invention  relates  to  a  partial  ester derived from the reaction product of an oxirane containing acid or derivative thereof, and a reactive hydroxyl compound selected from the group consisting of diols,  triols,  di-diols  and  1,4-dihydroxy butane  and  a halogen containing polymer compositon thereof.  The  oxirane  compound  can be derived from the group consisting of epoxidized vegetable oil,  epoxidized  fish oil,  an aliphatic  or arylaliphatic containing craboxyl compound having an oxirane group in the aliphatic chain.
Patent CA-2082808-A1 (CA)
Title: Osmotically driven syringe
Inventor: THEEUWES FELIX
IPC: A61M5/145
Filed: 1991-07-01
Abstract: An implantable osmotically driven syringe (20) is disclosed which can be used to deliver a beneficial agent, such as a drug, at a predetermined rate over an extended period of time. A movable piston (24) divides the syringe (20) into a beneficial agent-containing compartment (23) and a driving compartment (26). The piston (24) is movable into a position wherein the driving compartment (26) has an unoccupied volume of essentially zero. The syringe (20) is driven by an osmotic engine (10) which has a shaped wall (12) surrounding, and in contact with, an osmotic solute (17). The wall (12) is comprised of a semipermeable and/or microporous material which is permeable to the external fluid (e.g., water) but is impermeable to the solute (17). The engine (10) also has a passageway (13) forming a fluid flow path between the osmotic solute (17) and the driving compartment (26). A portion of the wall (12) is exposed to a fluid-containing external environment. At least about 30 % of the wall (12) which contacts the solute (17) also is exposed to the fluid in the external environment. In operation, water from the external environment is imbibed through the semipermeable wall (12) forming a solution of the solvent (17) in the osmotic engine (10). As fresh incoming fluid from the external environment is imbibed by the engine (10), the solution is pumped through the passageway (13) into the driving compartment (26). The pumping action drives the piston (24) which causes the beneficial agent to be delivered by the syringe (20).
Patent CA-2083812-A1 (CA)
Title: Expression vectors and their use in the preparation of hiv-resistant human cells for therapeutic applications
Inventor: KRETSCHMER AXEL
IPC: C12N15/86
Filed: 1992-11-25
Abstract: Expression vectors and their use in the preparation of HIV-resistant human cells for therapeutic applications Abstract The present invention relates to the targeted blocking of the genetic information of the viral messenger ribo-nucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems,  which express a comple-mentary "antisense RNA".
Patent CA-2087334-A1 (CA)
Title: Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones
Inventor: BITONTI ALAN J
IPC: A61K31/44
Filed: 1992-04-14
Abstract: This invention is directed to pyridinyloxazole-2-ones which are useful in inhibiting metastasis in patients having cancer. The pyridinyloxazole-2-ones act to inhibit protein kinase C and thereby modulate metastasis in patients having cancer.
Patent CA-2087538-A1 (CA)
Title: Piperidine compounds, their preparation and use
Inventor: LUNDBECK JANE MARIE
IPC: A61K31/451
Filed: 1991-07-15
Abstract: Novel piperidine compounds having formula (I), wherein R3 is 3,4-methylenedioxyphenyl, phenyl, naphthyl, or a 5 or 6 membered heterocyclic group containing one or two N, O or S - atoms being saturated, partly saturated or aromatic which are optionally substituted with one or more halogen, amino, C1-6-alkyl mono- or disubstituted amino, C1-6-alkoxy, cyano, mono- or poly halogenated C1-6-alkyl, C2-6-alkenyl, C1-6-alkyl, C3-5-alkylene, trifluoromethoxy, hydroxy, hydroxy C1-4-alkyl, or trifluoromethyl;  n is 0 to 4; R1 is hydrogen, straight or branched C1-8-alkyl, C1-8-alkoxy-C1-8-alkyl, C3-8-cycloalkyl, C2-6-alkenyl, C4-8-cycloalkylalkyl, acetyl or C2-6-alkenyl; X is one or more amino, NO2, C1-6-alkyl mono- or disubstituted amino, C1-8-alkanoylamino, carboxy, C1-6-alkyl mono- or disubstituted ureido, C1-6-alkyl substituted with amino which are optionally mono-or disubstituted with C1-6-alkyl, unsubstituted carbamoyl or C1-6-alkyl optionally substituted with phenyl and/or hydroxy N-mono or disubstituted carbamoyl, unsubstituted sulfamoyl, C1-6-alkyl N-substituted sulfamoyl, C1-6-alkyl S-substituted sulfamoyl, C1-6-alkyl N-and S-substituted sulfamoyl, or a 5 or 6 membered heterocyclic group containing one or two N, O or S - atoms being saturated, partly saturated or aromatic, the heterocyclic group can be fused to the ring and, when Y is NR and/or n is 1 to 4 X  is halogen, C1-6-alkyl, C2-6-alkenyl, C3-8-cycloalkyl, C4-8-cycloalkylalkyl, C1-6-alkoxy, cyano, mono- or poly halogenated C1-6-alkyl, hydroxy or hydrogen; Y is O, S or NR wherein R  is hydrogen or C1-5-alkyl, or a salt thereof with a pharmaceutically-acceptable acid. The novel compounds are useful in the treatment of anoxia, traumatic injury, ischemia, migraine, epilepsy and other neurodegenerative diseases.