Patent SG-11201908502V-A (SG)
Title: Immunogenic peptide composition
Inventor: CHAI SAN JIUN
IPC: A61P35/00
Filed: 2018-03-15
Abstract: Filing Language: (26) Publication Language: (30) Priority Data: PI 2017700886 15 March 2018 (15.03.2018) English English 15 March 2017 (15.03.2017) MY (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT 0111111010 0111 °nolo Oil VIII oimIE (10) International Publication Number WO 2018/169385 Al (51) International Patent Classification: A61K 38/08 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) (21) International Application Number: PCT/MY2018/050011 (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4. 17(ii)) of inventorship (Rule 4.17(iv)) (71) Applicant: CANCER RESEARCH MALAYSIA [MY/MY]; No. 1, Jalan SS12/1A, Subang Jaya, 47500, Se- langor (MY). (72) Inventors: CHAI, San Jiun; c/o Cancer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Se- langor (MY). FONG, Sammuel Chee Yong; c/o Can- cer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Selangor (MY). GAN, Chai Phei; c/o Can- cer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Selangor (MY). PONNIAH, Sathibalan; 7008 Golden Seeds Row, Columbia, Maryland 21044 (US). PATEL, Vyomesh; c/o Cancer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Selangor (MY). CHEONG, Sok Ching; c/o Cancer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Selangor (MY). LIM, Kue Peng; c/o Cancer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya, 47500, Selangor (MY). (74) Agent: CHUAH, Jern Ern; ADVANZ FIDELIS SDN BHD, Suite 609, Block D, Phileo Damansara 1, No 9 Jalan 16/11, Petaling Jaya, Selangor, 46350 (MY). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE 00 00 O C (54) Title: IMMUNOGENIC PEPTIDE COMPOSITION (57) : The present invention relates to a peptide composition capable of binding with major histocompatibility complex class I molecules to induce an anti-cancer immune response in a subject. Particularly, the peptide composition comprises at least a Four jointed Box 1 peptide and a Melanoma Antigen family D4b peptide. The present invention further relates to the use of a peptide composition and a peptide vaccine for inducing the anti-cancer 0 immune response in the subject.