baber/WOPTO huggingface dataset:
Patent DE-69530209-D1 (DE)
Inventor: BRINGMANN GERHARD
IPC: A61K31/47
Filed: 1995-07-19
Granted: 2003-05-08
Abstract: The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The present invention also provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention further provides new, medically useful monomeric naphthylisoquinoline compounds and homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.
Patent DE-69531847-D1 (DE)
Inventor: BRAUN DAVID W
IPC: C08G18/00
Filed: 1995-05-26
Granted: 2003-11-06
Abstract: The present invention relates to a non-hydroxyl functional resin containing coating composition comprising:     a) an aldimine compound having the structure <CHEM>     wherein  n averages greater than 1, R1 is alkyl, aryl, cycloaliphatic or substituted alkyl, aryl, cycloaliphatic or heterocyclic group, and R2 is monomeric or polymeric aliphatic, aromatic, arylaliphatic or cycloaliphatic group which may contain O, N, S, or Si, b) an isocyanate functional component comprising uretdione structure   c) optionally, other active hydrogen compounds.  f
Patent DE-69532301-D1 (DE)
Inventor: FINBURGH E
IPC: A61M5/00
Filed: 1995-09-08
Granted: 2004-01-22
Abstract: An air-in-line sensing apparatus for use with a parenteral fluid administration set to detect the passage of air through a fluid conduit. The apparatus comprises a first housing having a first arcuate section mounting a first transducer adjacent the first arcuate section and a second housing having a second arcuate section mounting a second transducer adjacent the second arcuate section. One housing is independently movable relative to the other housing so that when the movable housing is moved towards the other housing, the first and second arcuate sections capture a length of administration set tubing therebetween providing secure intimate contact therewith. A signal may be generated from one of such transducers, passed through the fluid conduit and received by the other transducer to detect whether the conduit is carrying air.
Patent DE-69533804-D1 (DE)
Inventor: SMITH R
IPC: A61K38/00
Filed: 1995-05-23
Granted: 2004-12-30
Abstract: Phage display methods were used to identify mimetics of SDI-1. Such mimetics are small peptides that are capable of binding to cyclin molecules, especially CDK2. The invention is directed to the mimetics and to methods for producing them.
Patent DE-69601142-D1 (DE)
Inventor: BROWN BRUCE G
IPC: F04B7/04
Filed: 1996-05-09
Granted: 1999-01-28
Abstract: A cryogenic pump is disclosed for pumping liquified gas from one container to another container or a point of use. The pump has a main housing (12) defining a cylinder in which a hollow piston (34) is reciprocable by means of a piston rod (42) and divides the interior of the main housing into a supercharger chamber (50) and a sump chamber (52). The lower end of the main housing is closed by a block (24) formed with a fixed piston (54), defining a high pressure chamber (60) in the hollow piston (34), and with inlet ports (76) leading into the sump chamber (52). An outer housing (14) defines a precharge chamber (82) around the main housing (12). During reciprocation of the hollow piston (34), liquid is drawn in through the ports (76) and progressively pumped, though non-return valves, in sequence through the sump chamber (52), the precharge chamber (82), the supercharger chamber (50), and the high pressure chamber (60) to an outlet line (136). The block (24) is located within and adjacent to the bottom of the container. The pump arrangement allows the container to be substantially emptied thereby avoiding waste of the contained liquified gas. <IMAGE>
Patent DE-69613045-D1 (DE)
Inventor: HART JACK ERNEST
IPC: B64D11/00
Filed: 1996-06-20
Granted: 2001-07-05
Abstract: Extensions for carry-on luggage storage bins in cabins of aircraft, trains, ships, and the like, that increase bin storage capacity. The extensions are adapted to be mounted on a frontal opening of an existing luggage bin (B). The extensions include a substantially planar rectangular base (52) having vertical bulkheads (54) at opposite farthest-apart ends thereof, and a substantially planar top portion (56) extending between upper ends of the bulkhead to form a rectangular box shape with open front and rear. The rear of the extension is adapted to be mounted onto the frontal opening of the bin, thereby extending the lateral dimensions of the bin, while the front of the extension may be supplied with a door (58). <IMAGE>
Patent DE-69613303-D1 (DE)
Inventor: STEPHENS RANDALL WAYNE
IPC: C07C69/65
Filed: 1996-09-27
Granted: 2001-07-19
Abstract: Disclosed is a method for preparing an  alpha , beta -unsaturated- beta -trifluoromethyl carboxylate of the formula: <CHEM>  wherein X is selected from OR<3>and NR<3>R<4>  comprising contacting a compound of the formula: <CHEM>  with a base to produce the  alpha , beta -unsaturated compound. The starting material can be prepared by  acylating a compound of the formula: <CHEM>   In the above formulas, R,R<1>,R<2>,R<3> and R<4> have the meanings given in the description.
Patent DE-69622716-D1 (DE)
Inventor: WEAVER RAYMOND
IPC: B29C63/34
Filed: 1996-05-21
Granted: 2002-09-05
Abstract: PCT No. PCT/GB96/01220 Sec. 371 Date Nov. 19, 1997 Sec. 102(e) Date Nov. 19, 1997 PCT Filed May 21, 1996 PCT Pub. No. WO96/37725 PCT Pub. Date Nov. 28, 1996Apparatus and method for producing reduction in maximum width in plastics lining pipes includes at least one pair of reducing rolls through which the lining pipe is forced from upstream thereof. The rolls are disposed and configured to present a roll throat of effective ovality, defined by the percentage difference between the maximum dimension normal to the axes of rotation and the maximum dimension parallel to the axes of rotation, in the range of 5% and 30%.
Patent DE-69636278-D1 (DE)
Inventor: TSUJINAKA TOSHIMASA
IPC: C07K16/28
Filed: 1996-02-13
Granted: 2006-08-03
Abstract: The present invention provides a muscle protein proteolysis inhibiting agent comprising antibody to Interleukin-6 receptor (IL-6R antibody). Antibodies of animals other than humans such as mice and rats, chimeric antibodies of these antibodies with human antibodies, and reshaped human antibodies and so forth can be used for the IL-6R antibody. The muscle protein proteolysis inhibiting agent of the present invention is useful in the inhibition of muscle protein proteolysis observed in diseases such as cancerous cachexia, sepsis, serious trauma or muscular dystrophy.
Patent DE-69638121-D1 (DE)
Inventor: SRIVASTAVA PRAMOD K
IPC: A61K39/12
Filed: 1996-09-11
Granted: 2010-03-18
Abstract: The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases. The methods of the invention comprise administering a composition comprising an effective amount of a complex, in which the complex consists essentially of a heat shock protein (hsp) noncovalently bound to an antigenic molecule. "Antigenic molecule" as used herein refers to the peptides with which the hsps are endogenously associated in vivo as well as exogenous antigens/immunogens (i.e., with which the hsps are not complexed in vivo) or antigenic/immunogenic fragments and derivatives thereof. In a preferred embodiment, the complex is autologous to the individual. The effective amounts of the complex are in the range of 10-600 micrograms for complexes comprising hsp70, 50-1000 micrograms for hsp90, and 10-600 micrograms for gp96. The invention also provides a method for measuring tumor rejection in vivo in an individual, preferably a human, comprising measuring the generation by the individual of MHC Class I-restricted CD8+ cytotoxic T lymphocytes specific to the tumor. Methods of purifying hsp70-peptide complexes are also provided.
Patent DE-69703473-D1 (DE)
Inventor: RIVOAL JACQUES
IPC: E04H4/00
Filed: 1997-08-05
Granted: 2000-12-14
Abstract: The slurry tank cover, either for a round or rectangular tank, is made from a sheet of PVC-coated polyester fabric (1), held under tension by an elastic line and parallel lacing cable (2) attached to a frame (3) which is supported at a given height above the edge of the tank (5) by posts (7). The frame (3) is situated at a sufficient height above the tank to prevent the interior of its concave surface from coming into contact with the slurry. A vertical apron (9) is welded to the edge of the cover to enclose the space between it and the tank wall, with the lower edge of the apron held in place by a line (21). The centre of the cover can be equipped with an outlet (12) and drainpipe (13), or a reservoir with an automatic pump, for evacuating rainwater.
Patent DE-69706018-D1 (DE)
Inventor: MIMEUR NICOLAS
IPC: A43B5/04
Filed: 1997-10-17
Granted: 2001-09-13
Abstract: The fixing attachment comprises a base (6) on which the boot sole is placed. The base is extended rearward to rise in an arc (7) which wedges the heel and by a rear cover (8) on which the boot ankle is supported. The rear cover comprises a lower part (8A) in the shape of a stirrup extending from the arc and pivoting on it about a transverse spindle (9). The cover upper part (8B) extends upward from the lower part and is pivoted on it. This pivoting is by means of a connection enabling modification of the relative positions of the two parts by rotation of the lower part about an axis (XX') in front of the cover.
Patent DE-69707850-D1 (DE)
Inventor: HAGSTROEM KJELL
IPC: G09F3/20
Filed: 1997-03-19
Granted: 2001-12-06
Abstract: Holder for marking labels, particularly for marking of electrical components. The holder comprises a coupling element (11) provided with at least two, and preferably three mounting surfaces (14, 16, 18) situated in different planes, a first one (14) of which is designed with an attachment part (15) for connection of a label ledger (13) to which said marking labels (31) are attachable, and at least a second mounting surface (16) for affixing the coupling element (11) via attachment means (12) to a base (33). The coupling element (11) is constituted by a L- or U-shaped profile, the shanks of which are designed to form said mounting surfaces (14, 16, 18). The end of one free shank (14) of the profile is designed with an attachment part (15) for attachment of the label ledger (13). At least one shank or the other shanks (16, 18) is/are provided with means for arresting the coupling element (11) to the base (33), which means are constituted by at least one, preferably non-round hole (17, 19) and a locking tab (20) designed for cooperation with the hole and having a corresponding cross section.
Patent DE-69707870-D1 (DE)
Inventor: WHEELER CARL J
IPC: C07C217/28
Filed: 1997-04-08
Granted: 2001-12-06
Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.
Patent DE-69707891-D1 (DE)
Inventor: SHIVANATH ROHITH
IPC: C21D7/00
Filed: 1997-05-02
Granted: 2001-12-06
Abstract: A method of making a sintered article of powder metal having a carbon composition in the range of about 0.8% to 2.0% by weight, then spheroidizing the sintered article and then warm forming the sintered article at a temperature between 250 DEG  and 700 DEG  C. for a time duration selected to form the article to a final shape.
Patent DE-69713115-D1 (DE)
Inventor: SCHOLZ F
IPC: C09J7/29
Filed: 1997-09-26
Granted: 2002-07-11
Abstract: Prelaminate pressure-sensitive adhesive (PSA) constructions comprise, a first substrate, a coating or release material on a surface of the first substrate, a PSA layer disposed on the coating of release material, and a detackified layer (DL) disposed on a surface of the PSA layer to form a continuous film covering the PSA layer. In first and second embodiments of the construction the DL is activatable to form a tacky layer on top of the PSA layer for lamination with a second substrate. In a third embodiment, the DL includes constituents that when activated migrate into the PSA layer to expose the PSA layer tacky surface for lamination with a second substrate. The prelaminate PSA constructions are completely nonblocking to a minimum 24 hour blocking temperature of about 50° C. at pressure of about 40 kilopascals, thereby allowing such prelaminate PSA construction to be collected, stored, and or transported before being laminated without adhesive interference occurring between continuous layers. The DL in each embodiment is activatable in less than five seconds to provide a tacky layer having a sufficient open tack time to permit lamination at less than about 100° C.
Patent DE-69713528-D1 (DE)
Inventor: ANDRE JEAN-LUC
IPC: F16H25/20
Filed: 1997-11-26
Granted: 2002-07-25
Abstract: The translation block with disengaging nut (15) comprises a translation body (4) which serves as a housing for the nut (15) and which slides along the guide element (7) surrounding the screw. The interior unit comprises the nut (15) formed of two mechanically identical pieces (29, 30) which are attached to the screw (13) and separated by an elastic restraint, and an immobilizing-release device (18) cooperating with blocking grooves (42) on the nut, comprised of two flanges (20, 21) each pivoting on an axle parallel to the screw, elastically joined to the nut and released through the action of a pneumatic force. This invention is of interest to manufacturers of storage devices, for example, screw-mounted lifting mechanisms for vehicle transport trailers.
Patent DE-69724241-D1 (DE)
Inventor: KLEIN D
IPC: A61K38/00
Filed: 1997-03-13
Granted: 2003-09-25
Abstract: GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.
Patent DE-69724979-D1 (DE)
Inventor: MARTIN R
IPC: G02C5/00
Filed: 1997-03-18
Granted: 2003-10-23
Abstract: Eyewear 10 comprises a frame 12 for housing a pair of lenses 14 therein. The frame 12 has a bridge portion 16 for bridging a user's nose and a pair of temple members 18 for locating the frame 12 in position on the head of a user. The frame 12 has a nose pad 20 in the form of a projection extending downwardly from the bridge portion 16 for resting by gravity on the frontal part of the bridge of a user's nose at the origin of the nose. According to another embodiment, a nose pad 30 which is detachable from the frame 12 is provided. The frame 12 and the nose pad 30 are provided with mutually engaging formations 32, 34 for detachably attaching the nose pad 30 to the frame 12.
Patent DE-69728488-D1 (DE)
Inventor: VAN DOORN JAN CAREL
IPC: D05C17/02
Filed: 1997-10-16
Granted: 2004-05-13
Abstract: The invention relates to a method for manufacturing a carpet by starting from a fabric and tufting threads or yarns therein, and applying a layer of latex to the semi-finished product thus obtained, wherein the layer of latex is applied to the pile side. The invention also relates to a carpet consisting of a fabric with thread and yarn tufted therein and with a layer of latex present on the semi-finished product thus obtained, wherein the layer of latex is present on the pole side.
Patent DE-69733353-D1 (DE)
Inventor: QI MAO
IPC: A61P11/06
Filed: 1997-02-28
Granted: 2005-06-30
Abstract: Compounds and methods for use in immunosuppressive and anti-inflammatory treatment are described. The compounds are triptolide analogs with improved water solubility and low toxicity.
Patent DE-69733947-D1 (DE)
Inventor: ISE WOLFGANG
IPC: G01N30/95
Filed: 1997-05-14
Granted: 2005-09-15
Abstract: This-layer chromatography is used to separate, identify and quantity hydrophobic protein, hydrophobic protein fragment, hydrophobic modified protein and hydrophobic peptide. A method is thus provided for determination of proteins and peptides which, due to their low solubility in an aqueous solvent system, cannot be determined by conventional methods, such as ELISA, which are based on aqueous solvent systems.
Patent DE-69735686-D1 (DE)
Inventor: OSBOURN JANE KATHERINE
IPC: G01N33/532
Filed: 1997-07-08
Granted: 2006-05-24
Abstract: A method of labelling molecules which includes providing in a common medium a label molecule, a marker ligand able to bind a member of a specific binding pair, such as an antigen, a sbp member, an enzyme able to catalyse binding of the label molecule to other molecules, the enzyme being associated with the marker ligand; causing or allowing binding of the marker ligand to the sbp member; and causing or allowing binding of the label molecule to other molecules in the vicinity of the marker ligand bound to the sbp member. The marker ligand may be an antibody or any specific binding molecule, such as a chemokine or cytokine. A complementary member of the specific binding pair may be included, e.g. an antibody, or a diverse population of such sbp members, e.g. antibodies, may be included within which those which bind the counterpart sbp member, e.g. antigen, may be labelled and subsequently isolated for manipulation and/or use. Suitable labels include biotin-tyramine with signal transfer being catalysed by hydrogen peroxidase. Cells, virus particles and other moieties may be labelled, for identification or obtention of proteins which interact or are in close proximity with a particular sbp member, or of cells of interest, or for enhancement of labelling, e.g. for cell sorting.
Patent DE-69737633-D1 (DE)
Inventor: NATHANS JEREMY
IPC: C07K16/24
Filed: 1997-08-27
Granted: 2007-05-31
Abstract: The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
Patent DE-69740054-D1 (DE)
Inventor: DANDL RAPHAEL A
IPC: H05H1/46
Filed: 1997-07-01
Granted: 2010-12-30
Abstract: A method and apparatus are disclosed employing a microwave applicator for use with an electron cyclotron resonance (ECR) plasma source for applications including, but not limited to, etching and chemical vapor deposition. A magnetic field is generated by magnets circumferentially arranged about a chamber that is symmetrical about its longitudinal axis. The microwave applicator, which comprises one or more pairs of slotted antenna arrays, injects and distributes microwave power about the entire periphery of a plasma forming portion of the chamber. The antenna arrays include a plurality of radiating stubs for radiating microwave power. The stubs are positioned along the arrays at predetermined intervals for efficiently distributing microwave power uniformly about the periphery of the plasma forming portion. The position and orientation of the radiating stubs cause microwave power to be launched into the plasma in the form of propagating waves with a polarization suitable of electron cyclotron heating. The applicator is coupled to a microwave power source that preferably supplies microwave power at a frequency of 2.45 GHz. A magnetic-field free region produces uniformity of plasma distribution in a plasma stream that approaches an outlet in the chamber. The plasma stream flows through the plasma forming region toward the specimen with characteristics of high density, uniformity over transverse dimensions larger than the specimen, and low plasma temperature, while operating at gas pressures which can be varied over a wide range.
Patent DE-69740090-D1 (DE)
Inventor: VOS PIETER
IPC: A01H5/10
Filed: 1997-08-08
Granted: 2011-02-10
Abstract: All or part of a 9870 bp nucleic acid sequence (I), or a sequence homologous to this sequence is claimed. More specifically, (I) is an approximately 9.9 kb sequence located around the AFLP marker PM14, this region comprises the Meloidogyne incognita (Mi) resistance gene (nucleotides 3263-7111 of the 9870 bp sequence which comprises two intronic sequences). The Mi resistance gene product has a sequence of 1257 amino acids (given in the specification).
Patent DE-69800744-D1 (DE)
Inventor: ARNETOLI FABRIZIO
IPC: A01D34/416
Filed: 1998-07-15
Granted: 2001-06-07
Abstract: The cord-type grass-cutting head comprises a container (3, 4) having arranged inside it at least- one reel (5) of cutting cord (F), the ends of which emerge from holes in said container, and operating means for controlled unwinding of said cord from said reel, which means comprise a sliding actuating member (17, 19) projecting from said container, a slit being defined between the sliding member and the container. A flexible protective membrane (33) which covers said slit between the sliding member (17, 19) and said container (3, 4) is provided. <IMAGE>
Patent DE-69801196-D1 (DE)
Inventor: LAVIELLE GILBERT
IPC: A61P9/00
Filed: 1998-09-01
Granted: 2001-08-30
Abstract: 1-Substituted indole and indazole 1,3,4-triazoles (I) are new. They are prepared from 1-unsubstituted 3,4,5,or 6-nitro or hydroxy methyl indoles and indazole (IIa) or (II/b) by 1-substitution followed by reduction of the nitro group or by reaction of a hydroxy methyl group with an azide followed by reduction, to give an amine, and reaction of this with N,N-dimethyl formamide azine to form the triazole group.   Independent claims are also included to the preparation of (I). PHARMACEUTICALS - (I) may be used to treat venous insufficiency and associated disorders, migraines, pain, and migraines associated with vascular disorders such as hypertension, obesity, and alimentary disorders.
Patent DE-69801649-D1 (DE)
Inventor: GUILHEM JACQUES
IPC: B05D7/02
Filed: 1998-01-30
Granted: 2001-10-18
Abstract: A method and a machine for surface sizing of soft pieces (3) with porous surface such as fabrics and foams, with liquid glue, includes preheating the surface of each piece (3) at a temperature higher than 50° C., then spraying the liquid glue by low pressure atomization on the pre-heated surface, thus preventing the glue from penetrating the thickness of the piece.