baber/WOPTO huggingface dataset:
Patent IL-104713-A0 (IL)
Title: 3,5-substituted benzoylguanidines,process for their preparation,their use as a medicament or diagnostic and medicament containing them
IPC: C07C317/42
Filed: 1993-02-12
Abstract: There are described benzoylguanidines of the formula I <IMAGE> where R(1) is equal to R(4)-SOm or R(5)R(6)N-SO2-, where R(4) and R(5) are equal to alk(en)yl, -CnH2n-R(7), and where R(7) is equal to cycloalkyl or phenyl, where R(5) also denotes H, R(6) is equal to H or C1-C4-alkyl, R(2) is hydrogen, halogen, alkyl, -O-(CH2)mCpF2p+1, -X-R(10), where X is equal to O, S, NR(11), R(10) is equal to H, (cyclo)alkyl(methyl), -CnH2n-R(12) where R(12) is equal to phenyl, R(3), inter alia, is defined as R(1),  and their pharmaceutically tolerable salts. The compounds I are prepared by reaction of compounds of the formula II <IMAGE> in which L represents a leaving group which can be easily substituted nucleophilically, with guanidine. Compounds I are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infract treatment and for the treatment of angina pectoris, where they also preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage. They are moreover distinguished by a strong inhibitory action on cell proliferation. They can therefore be used as antiatherosclerotics, agents against diabetic late complications, cancers, fibrotic disorders such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys. They are effective inhibitors of the cellular sodium/protons antiporter (Na<+>/H<+> exchanger).
Patent IL-105140-A0 (IL)
Title: Pyridyloxy derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IPC: C07D213/70
Filed: 1993-03-23
Abstract: Compounds of formula (I) : <CHEM> [wherein: R<1> is a cyclic amino group, or a dialkylamino group; R<2> is a group of formula -NHCHR<3>R<4>, wherein R<3> and R<4> are each alkyl, aryl or aralkyl, or together form a cycloalkyl group, or R<2> is an aromatic heterocyclic group, or a group of formula -B-S(O)m-R<5>, wherein R<5> is a substituted alkyl group, or an aromatic heterocyclic group; B is an alkylene or alkylidene group; m is 0, 1 or 2; A is a group of formula -CH=CH- or -(CH2)n-, where n is 1, 2 or 3]; and salts thereof have valuable anti-ulcer activity.
Patent IL-106847-A0 (IL)
Title: Workpiece positioning apparatus
IPC: D05B35/10
Filed: 1993-08-31
Abstract: PCT No. PCT/GB93/01839 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Aug. 31, 1993 PCT Pub. No. WO94/05843 PCT Pub. Date Mar. 17, 1994Two workpiece portions (30, 32) that are to be stitched together along a stitching path (28) each have a stitching region (24, 26) which corresponds to the stitching path (28), but which is so shaped that the regions do not overlap when the workpieces (30, 32) are in a substantially flat condition. Thus some three-dimensional shaping is imparted to the portions during stitching. Each of the workpiece portions (30, 32) is clamped between two rollers (10, 12, 24) one of which is driven and the other freely rotatable, the driven rollers (10, 12) serving to distort the stitching regions into a desired overlapping position progressively in preparation for each successive stitching operation. The rollers are also bodily movable to advance the workpiece portions (30, 32) step-by-step through the operating locality (4) of the sewing machine. For sensing when the stitching regions are in the desired overlapping relationship suitable edge sensing means (40, 42, 44) is provided.
Patent IL-115014-A0 (IL)
Title: Methods of inhibiting viral replication
IPC: C07D333/56
Filed: 1995-08-21
Abstract: A method of inhibiting viral replication comprising administering to a human in need thereof an effective amount of a compound having the formula    <IMAGE>  (I)  wherein R1 and R3 are independently hydrogen, -CH3,   <IMAGE>   wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Patent IL-122329-A0 (IL)
Title: Liposomal human calcitonin gene-related peptide composition and preparation of the same
IPC: A61P9/00
Filed: 1997-11-27
Abstract: The present invention provides a pharmaceutical composition of hCGRP and the preparation of the same. The composition comprises liposomes from natural soybean phospholipid, in which the weight ratio of hCGRP to soybean phospholipid is 1-2 to 100-8000. The half-life of the composition is longer than 72 hours, and the stability of the composition is also elongated. The composition can be administrated by intravenous infusion, oral, nasal mucosal spray in an amount of 0.1-10 pg hCGRP per kg body weigh to treat hypertension and congestive heart failure of a human. The bioavailability of approximately 80%.
Patent IL-133891-A0 (IL)
Title: 2-valproenoic acid amide derivatives, their preparation and pharmaceutical compositions containing them
IPC: A61K9/08
Filed: 2000-01-05
Abstract: A compound having the structure:   <IMAGE>   wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3. Also provided are a compound containing a 2-valproenoic moiety, pharmaceutical compositions comprising these compounds, and methods of using them for the effective treatment of epilepsy and other neurological disorders.
Patent IL-133974-A0 (IL)
Title: Derivatives of growth hormone and related proteins
IPC: C07K14/56
Filed: 1998-07-13
Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
Patent IL-141606-A0 (IL)
Title: Breast pump insert
IPC: A61M1/06
Filed: 1999-08-23
Abstract: A flexible resilient breast pump insert adapted to fit onto a vacuum generating breast pump operable to cyclically generate and release a negative pressure is disclosed. The insert has deformable zones (11, 14) spaced from each other along the longitudinal axis of the insert which are connected to the source of negative pressure so that the zones (11, 14) are deformed sequentially when the negative pressure is applied, to cause them to move inwardly and outwardly relative to the users nipple and areola and apply a peristaltic pressure thereto.
Patent IL-142082-A0 (IL)
Title: Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
IPC: C07D311/74
Filed: 1999-09-23
Abstract: The present invention provides an antiproliferative compound having the structural formulawherein X is oxygen, nitrogen or sulfur; R<1 >is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R<2 >is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R<3 >is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R<4 >is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R<5 >is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
Patent IL-147602-A0 (IL)
Title: Detection system with video camera
IPC: G08B13/24
Filed: 2000-07-13
Abstract: Detection system comprising at least a receiver, a detector and an element that can be brought into one or more predetermined states. The receiver reacts to the states of the element when the latter is brought into the vicinity of the receiver. The receiver controls the detector in order to emit a detection signal that is associated with the state of the element. There is a video camera focused on the surroundings of the receiver for recording the wearer wearing the element and a memory device is installed for storing the images recorded by the video camera.
Patent IL-148585-A0 (IL)
Title: High refractive index thermoplastic polyposphonates
IPC: G02B5/23
Filed: 2000-11-10
Abstract: High refractive index, melt processable polyphosphonates and methods for preparing the same are provided. These polymers are particularly useful for optical and ophthalmic parts, such as lenses. A method of preparing optical and ophthalmic lenses by injection molding the polymers of the present invention into the form of the optical or ophthalmic lenses is also provided.
Patent IL-159241-A0 (IL)
Title: Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
IPC: A61K31/22
Filed: 2002-06-24
Abstract: The present invention relates to compounds and pharmaceutical compositions useful for treating pain. The invention also relates to methods of treating or alleviating pain in mammals, comprising administering to a mammal suffering from pain, a pain-alleviating amount of a compound of the general formula (I) or (II).
Patent IL-161373-A0 (IL)
Title: Cutting tool and cutting insert
IPC: B23C5/08
Filed: 2004-04-14
Abstract: This invention relates to a cutting insert (14) comprising a cutting portion (24) and a locating portion (26). The cutting portion comprises a cutting edge (28) formed at the intersection of a rake surface (30) and a relief surface (32). The cutting insert (14) further comprises an upper surface (34), a lower surface (36) and a peripheral side surface therebetween, wherein said peripheral side surface comprises opposing forward and rearward surfaces (38, 40) and opposing side surfaces (42) extending between the forward and rearward surfaces (38, 40). The relief surface (32) is located in the forward surface (38) and the rake surface (30) is located in the upper surface (34). The locating portion (26) extends downwardly from the cutting portion (24) away from the upper surface (34). Said locating portion (26) comprises opposing forward and rear locating surfaces(44, 46) wherein the rear locating surface (46) is located in the rear surface (40) wherein the forward and rearward locating surfaces (44, 46) converge downwardly. The rear locating surface (46) is located in the rear surface (40) and the forward locating surface (44) is located in the lower surface (36). A lower locating surface (48) is located in the lower surface (36) and opposes the upper surface (34) and extends between the forward surface (38) and the forward locating surface (44). The lower locating surface (48) is characterized in that in a side view of the cutting insert (14) the rear surface (40) is straight.
Patent IL-161978-A0 (IL)
Title: Method for treating cervical cancer
IPC: A61K38/00
Filed: 2002-12-17
Abstract: There is provided the use of IL-20 for the manufacture of a medicament for treating an individual infected with human papillomavirus (HPV).
Patent IL-172853-A0 (IL)
Title: Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
IPC: A61K31/282
Filed: 2005-12-27
Abstract: The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal which is optionally being treated with ionising radiation, which comprises the administration of ZD6474 in combination with a platinum anti-tumour agent; to a pharmaceutical composition comprising ZD6474 and a platinum anti-tumour agent; to a combination product comprising ZD6474 and a platinum anti-tumour agent for use in a method of treatment of a human or animal body by therapy; and to a kit comprising ZD6474 and a platinum anti-tumour agent.
Patent IL-178739-A0 (IL)
Title: Medicinal aerosol formulation products with improved chemical stability
IPC: B65D83/14
Filed: 2006-10-19
Abstract: The present invention relates to a medicinal aerosol formulation product with improved chemical stability. The product is a pressurized metered dose inhaler including an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent. The accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof. The pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting beta2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.
Patent IL-181743-A0 (IL)
Title: Device and method for generating a multi-channel signal or a parameter data set
IPC: G10L19/008
Filed: 2007-03-06
Abstract: For flexibly signaling a synchronous mode or an asynchronous mode in the multi-channel parameter reconstruction, a parameter configuration cue is inserted in the data stream, which is used by a configurator on the side of a multi-channel decoder to configure a multi-channel reconstructor. If the parameter configuration cue has a first meaning, the configurator will look for further configuration information in its input data, while, when the parameter configuration cue has another meaning, the configurator performs a configuration setting of the multi-channel reconstructor based on information on a coding algorithm with which transmission channel data have been coded, so that it is ensured efficiently on the one hand and flexibly on the other hand that there will always be obtained a correct association between parameter data and decoded transmission channel data.
Patent IL-183028-A0 (IL)
Title: Therapeutic agent for drug dependence
Filed: 2007-05-07
Abstract: The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such as stimulant substances, opioids, barbiturate type anesthetics, hallucinogens, cocaine, hemp, cannabis, alcohol, or volatile organic solvents. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is useful as a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior associated with craving for addictive substances.
Patent IL-195806-A0 (IL)
Title: Machine tool and cutting ring for a machine tool
Filed: 2008-12-09
Abstract: The invention relates to a machine tool for use in tool machines, comprising a cutting element which is preferably configured as a cutting ring and at least two insert seats that are provided in the cutting element at distance to each other in the circumferential direction. The insert seats are fitted with at least one group of at least two identical insert tips that are detachably arranged therein and that have one working edge each, the effective working edges of the insert tips of one group being cut to the same nominal size. The insert tips are configured as indexable inserts, every single indexable insert of a group being associated with a defined insert seat in all possible positions of adjustment, and the indexable inserts of a group having at least two working edges each, one of these edges being always in the effective and at least one other edge being in the ineffective position, depending on the position of the indexable inserts in the associated insert seats. The indexable inserts of a group assume identical positions of adjustment in which defined working edges of every indexable insert of a group have the same orientation in the associated insert seat, the working edges of the indexable inserts of a group being cut to a nominal size in all common positions of adjustment.
Patent RO-126011-A0 (RO)
Title: Sleep girdle for pregnant women
Inventor: COJOCARIU MARIA MAGDALENA
IPC: A41C1/10
Filed: 2010-09-13
Abstract: The invention relates to a sleep girdle meant to support the abdomen of a pregnant woman during the sleep. According to the invention, the girdle consists of a central part (1) made of cotton, placed on a portion (7) of the back of a pregnant woman, two side parts (2a and 2b) provided with some slots (11a and 11b) wherethrough some sponges (3a and 3b) of various sizes, for the three pregnancy stages, can be introduced and which can be changed during the 9 pregnancy months, and two connecting parts (4a and 4b) to attach the side parts (2a and 2b), which are provided with two belts (8) for fixing the girdle on the waist of the pregnant woman.
Patent AU-2003900357-A0 (AU)
Title: An improved smelting process for the production of iron
IPC: C21B3/06
Filed: 2003-01-24
Abstract: A process for producing iron metal and slag by smelting iron-containing source material, having iron present as oxide and/or a partially metalized state, in a reactor containing a molten bath comprising or having a slag phase, utilises injection of fuel/reductant and oxygen-containing gas into the slag, by at least one top-submerged lance, to generate heating and reducing conditions in at least one reducing region in the bath. The source material is fed to the reactor, together with additional reductant and with flux, at or adjacent to the at least one reducing region, to subject the source material to smelting reduction which generates combustion gases comprising CO and H2. The rates of injection of the oxygen-containing gas and fuel/reductant by said at least one lance are controlled to achieve required, sufficient reducing conditions; and, in the reactor above the bath, the combustion gases generated by the smelting are post-combusted. The controlling of step (c) is conducted to result in the injected oxygen-containing gas having an oxygen content of from about 40 volume % to about 100 volume % and sufficient for a degree of combustion in excess of 60 wt % of the fuel/reductant injected by the at least one lance.
Patent MC-2213-A1 (MC)
Inventor: DEVENISH DONALD
IPC: E05F15/04
Filed: 1990-11-09
Abstract: PCT No. PCT/AU90/00546 Sec. 371 Date May 11, 1992 Sec. 102(e) Date May 11, 1992 PCT Filed Nov. 9, 1990 PCT Pub. No. WO91/07594 PCT Pub. Date May 30, 1991.A gas actuator (21) and a pop-up target (10) incorporating the gas actuator (21) are disclosed. The gas actuator (21) comprises support surfaces (24, 26), pivoting surfaces 5 (64,66) pivotably coupled upon the support surfaces (24, 26), respectively, and flexible and inflatable members (18, 20) disposed for pivoting the pivoting surfaces (64, 66) with respect to the support surfaces (24, 26) between a first and a second position. The members (18, 20) act over a relatively large area between the support surfaces (24, 26) and the pivoting surfaces (64, 66). The magnitude of the pivoting force produced by the members (18, 20) increases to a maximum and thereafter decreases as the pivoting surface (64) pivots upwards. An accumulator (104) allows for relatively low flow rates of as from a source of compressed as (102) and provides relatively high flow rates of compressed as to the members (18, 20).
Patent IE-900308-A1 (IE)
Title: Improvements in and relating to random access memory and¹processing utilization in microcomputers
Filed: 1990-01-29
Abstract: A computerised document generating apparatus for use in generation and printing of documents having a relatively large number of data values. Such documents may include reports 5 relating to performance of industrial processes, said reports including parameter values for the processes. The apparatus utilises random access memory and permanent and exchangeable magnetic disks in a manner which allows use of data values from a large number of files without excessive requirements of 10 the random access memory circuit during generation and printing of a document. This is achieved by use of a target file which is stored in the random access memory circuit and receives values from other files before generation and printing of a document. The data values of the target data 15 file are independent, and may be processed without reference to values of other files. The target data file is arranged to provide information for a document to be generated without reference to other files which have beforehand been transmitted for storage in the exchangeable magnetic disk.
Patent LU-84806-A1 (LU)
Inventor: SANDRIN ROMEDIO
IPC: C07C7/08
Filed: 1983-05-13
Abstract: Tert.butyl alkyl ethers are produced from a C4 hydrocarbon feedstock containing isobutene, and the butene-1 is recovered at high purity by extractive distillation of the isobutene-free C4 hydrocarbon stream in the presence of a solvent chosen from acetone, acetonitrile, dimethylformamide, methanol, n-methylpyrrolidone, formylmorpholine and furfural. After removing the solvent, the extract is rectified, and the butene-1 separates as overhead product of high purity.
Patent MA-18813-A1 (MA)
IPC: C08F2/34
Filed: 1980-04-18
Abstract: The danger of explosion due to decomposition of high-pressure industrial process gases, such as ethylene, is reduced by maintaining in an inert atmosphere at least part of an evacuation system included between a pressurized vessel within which the decomposition may take place, on the one hand, and the atmosphere, on the other. The evacuation system to the atmosphere for the gases contained in the high-pressure vessel, includes (1) an evacuation pipe adjacent to the vesel; (2) a safety means separating the evacuation pipe from the vessel; (3) a sealing means located in the evacuation path of the gases and occupying the entire cross-section of the evacuation pipe; (4) a first gas supply circuit connected by a pipe to that part of the evacuation pipe that is located between the safety means and the sealing means, and means for the first supply pipe to control the volume of gas supplied by the first supply circuit; and (5) a second gas supply circuit connected by a pipe to the sealing system, and means for the second supply pipe to control the volume of gas fed by the second supply circuit. The apparatus is useful for the recovery of decomposition products for the purpose of averting atmospheric pollution, as well as for reducing the risk of explosion.
Patent MA-24625-A1 (MA)
Inventor: EMILE ROCHE
IPC: F17D1/20
Filed: 1998-07-31
Abstract: The air inlet device (7), for a system comprising a hydropneumatic reservoir (3) mounted on a pipe, is positioned so that the air is let into a zone containing water at an absolute pressure which is below or slightly above atmospheric pressure, and is actuated only when the hydropneumatic reservoir needs re-filling with air. The inlet device comprises an air feed tube (8), mounted on the pipe between the water intake and a pump (2) equipped with an electrically-driven air control valve and a flow limiter. The pipe is equipped with a vacuum generator upstream of the hydropneumatic reservoir, e.g. in the form of a Venturi tube.