baber/WOPTO huggingface dataset:
Patent WO-2021188134-A1 (WO)
Title: Voltage-controlled interlayer exchange coupling magnetoresistive memory device and method of operating thereof
Inventor: KALITSOV ALAN
IPC: H01L43/12
Filed: 2020-06-16
Abstract: A magnetoresistive memory device includes a magnetic tunnel junction comprising a free layer, a reference layer, and an insulating tunnel barrier layer located between the free layer and the reference layer, a perpendicular magnetic anisotropy (PMA) ferromagnetic layer that is vertically spaced from the free layer, an electrically conductive, non-magnetic interlayer exchange coupling layer located between the free layer and the PMA ferromagnetic layer. The magnetoresistive memory device is a hybrid magnetoresistive memory device which is programmed by a combination of a spin-torque transfer effect and a voltage-controlled exchange coupling effect.
Patent WO-2021015894-A1 (WO)
Title: Composition for and method of improving tissue performance
Inventor: MA JIANJIE
IPC: A61K38/02
Filed: 2020-06-17
Abstract: Compositions for and methods of improving tissue function are provided, Said compositions comprise MGS 3 or express MGS 3. Said compositions can be used for improving the function of non-diseased and uninjured tissue in subjects.
Patent WO-2020257415-A1 (WO)
Inventor: AMBROISE BENOÎT
IPC: B32B27/08
Filed: 2020-06-18
Abstract: Disclosed are compositions and methods for multilayer films, which, in one embodiment may comprise a core layer comprising at least 50 wt.% of high-density polyethylene. Further, the multilayer film may include a first skin layer comprising at least 80 wt.% of high-density polyethylene, and a second skin layer comprising either: (i) one or more low-density polyethylenes; or (ii) one or more polypropylene-based copolymers. The multilayer film may be oriented in at least one direction.
Patent WO-2020263696-A1 (WO)
Inventor: FERREIRA SILVINO M
IPC: A47F1/08
Filed: 2020-06-19
Abstract: An inventory storage system including a container with an upper surface, a lower surface, a back wall and a front wall facing a width of the upper surface and the lower surface, a first removal slot disposed between the front wall and the lower surface, and a pair of sidewalls facing a length of the upper and lower surfaces. The container includes dividers defining one or more sections. The container includes pens stored within the sections of the container, the pens including at least a subset of first pens and a subset of second pens, with the subset of first pens is below the subset of second pens. The container includes spacers that prevent the subset of second pens from exiting the container via the first removal slot until the subset of first pens exit the container via the first removal slot.
Patent WO-2021194535-A1 (WO)
Title: Dispositif de mémoire tridimensionnel comprenant une couche d'arrêt de gravure inter-niveaux et son procédé de fabrication
Inventor: LEE YAO-SHENG
IPC: H01L27/11582
Filed: 2020-06-22
Abstract: La présente invention concerne un dispositif de mémoire tridimensionnel qui comprend un empilement alterné de première niveau de premières couches isolantes et de premières couches électroconductrices situées sur un substrat, une couche de matériau d'arrêt de gravure située au-dessus de l'empilement alterné de premier niveau, un empilement alterné de second niveau de secondes couches isolantes et de secondes couches électroconductrices situées sur la couche de matériau d'arrêt de gravure, des ouvertures de mémoire inter-niveaux s'étendant verticalement à travers l'empilement alterné de second niveau, la couche de matériau d'arrêt de gravure, et l'empilement alterné de premier niveau, et des structures de remplissage d'ouverture de mémoire comprenant chacune un film de mémoire et un canal semi-conducteur vertical situé dans les ouvertures de mémoire inter-niveaux. Le matériau de la couche de matériau d'arrêt de gravure est différent des matériaux des premières couches isolantes, des secondes couches isolantes, des premières couches électroconductrices et des secondes couches électroconductrices.
Patent WO-2021003477-A1 (WO)
Inventor: ANDERSON DERRICK
IPC: C11D1/94
Filed: 2020-07-06
Abstract: The disclosure relates to hard surface cleaning compositions, methods of making the hard surface cleaning compositions, and methods of using the hard surface cleaning compositions. In particular, the hard surface cleaning compositions have reduced surface tension for cleaning surfaces with low surface free energy. Preferably, the hard surface cleaning compositions have low contact angles on a variety of surfaces.
Patent WO-2021021397-A1 (WO)
Inventor: SAENZ VILLALOBOS GONZALO JOSE
IPC: A61B17/128
Filed: 2020-07-07
Abstract: A device includes a flexible insertion section extending from a distal end which, during use is inserted to a target site to a proximal end which remains outside the body; an end effector coupled to a distal end of the insertion section; and a control wire received within the insertion section and extending from a proximal end coupled to an actuator to a distal end coupled to the end effector. The control wire is movable within the insertion section to operate the end effector. The control wire and the insertion section include a bend in a distal portion thereof configured so that, in a resting state, the control wire and the insertion section bend through a predetermined arc at a selected bending radius. A distal portion of the control passes into and through a working channel of an insertion device without plastic deformation of the control wire.
Patent WO-2021030382-A1 (WO)
Inventor: CARDONA EDGARDO
IPC: A61G3/08
Filed: 2020-08-12
Abstract: The embodiments described and claimed herein include an automated securement system that secures a wheeled mobility device for transit in a vehicle, and periodically re-secures the wheelchair to ensure proper securement despite shifting of the wheelchair during transit. The embodiments also include improvements to a compression-based wheeled mobility device securement system.
Patent WO-2021034653-A1 (WO)
Title: Combination therapy with gold controlled transgenes
Inventor: WANG BENJAMIN
IPC: C12N15/67
Filed: 2020-08-14
Abstract: Control Devices are disclosed including RNA destabilizing elements (RDE) combined with transgenes, including Chimeric Antigen Receptors (CARs) in eukaryotic cells. These RDEs can be used to optimize expression of transgenes, e.g., CARs, in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered at desired times from the eukaryotic cell. Such CAR T-cells with transgene payloads can be combined with the administration of other molecules, e.g., other therapeutics such as anticancer therapies.
Patent WO-2021035050-A1 (WO)
Title: Anchor designs with adaptable length control
Inventor: KRUMPELMANN GRAHAM
IPC: A61F2/24
Filed: 2020-08-20
Abstract: An implant, system, and method of deployment includes a plurality of anchor housings coupled to one of the proximal end or distal end of an implant frame. Each anchor housing may include an anchor sleeve disposed within a bore of the anchor housing, the anchor sleeve having a lumen extending therethrough including features disposed on an internal wall of the lumen for translatably supporting at least one anchor. Each anchor sleeve may be independently translatable within the bore of the anchor housing to control a distal extent of travel of the at least one anchor through the at least one anchor housing.
Patent WO-2021050263-A1 (WO)
Title: METHOD AND SYSTEM OF BEER SHELF LIFE EXTENSION BY pH NEUTRALIZATION
Inventor: HAVEL FREDERIK
IPC: C12H6/00
Filed: 2020-08-25
Abstract: Methods and systems are provided that suppress or arrest oxidation in beer by altering the pH level of beer to a neutralized state. An appropriate pH level for the beer, where oxidation reactions are suppressed, is determined and the beer is subjected to an alkaline substrate that raises the original pH level of the beer to an increased pH level. The alkaline substrate releases hydroxyl ions into the beer, raising the pH level, without requiring the addition of chemicals or compounds to alter the pH level. This pH-neutralized beer may be stored or shipped and then returned to a target pH-adjusted level by subjecting the pH-neutralized beer to a pH-adjustment treatment. The pH adjustment treatment uses an ion exchange substrate to extract a predetermined amount of the hydroxyl ions from the pH-neutralized beer producing a target pH-adjusted beer having a lower pH level at the original target fresh flavor.
Patent WO-2021055306-A1 (WO)
Title: Dual capture method for analysis of antibody-drug conjugates
Inventor: KOTAPATI SRIKANTH
IPC: G01N33/68
Filed: 2020-09-15
Abstract: A method for analyzing whether, and to what extent, a transformation has occurred in the partner molecule component of an antibody-drug conjugate.
Patent WO-2021076885-A1 (WO)
Inventor: HOLLAND SEANAN R
IPC: H02K3/28
Filed: 2020-10-16
Abstract: A motor comprising: (a) a stator having a plurality of ferrous cores surrounded by a plurality of windings; (b) a pair of rotors positioned on opposing sides of the stator, each rotor including a ring gear; and (c) a drive shaft extending through a cutout of the stator, the drive shaft having a pinion gear positioned near an end of the drive shaft in communication with the ring gears of the rotors; wherein the rotors rotate in opposing directions so that the ring gears translate a movement of the rotors to the drive shaft through the pinion gear to rotate the drive shaft in a direction substantially orthogonal to a direction of rotation of the rotors.
Patent WO-2021087257-A1 (WO)
Title: Voice-driven navigation of dynamic audio files
Inventor: KRAFTSOW ANDREW
IPC: G10L15/22
Filed: 2020-10-30
Abstract: A system for investigating, organizing, connecting and accumulating user feedback on dynamic libraries consisting primarily, but not exclusively, of audio files.
Patent WO-2021087438-A1 (WO)
Inventor: SEN CHANDAN K
IPC: H01B13/18
Filed: 2020-11-02
Abstract: Technologies for fibers with nanotechnology is disclosed. In the illustrative embodiment, a preform is 3D printed with one or more sacrificial cores and one or more hollow channels. The preform is drawn into a fiber, and one or more metal core(s) is inserted into the hollow channel during the fiber draw. The fiber is then heated, breaking up the sacrificial cores into balls through capillary action. The fiber can be etched, exposing the balls made up of the sacrificial cores. The balls can be selectively etched, exposing the metal core(s) of the fiber. Additional embodiments are disclosed.
Patent WO-2021097251-A1 (WO)
Title: Circuit interrupting device for providing ground fault and open neutral protection in temporary power applications
Inventor: ITZLER ROY
IPC: H02G3/02
Filed: 2020-11-13
Abstract: A temporary power delivery system includes a power source, a booth stringer, and a portable GFCI device. The GFCI device is receives current from the power source by a first terminal and delivers current to the booth stringer by a second terminal. An electronic processor of the GFCI device compares a combined magnitude of current flowing through first and second phase conductors of the GFCI device to a magnitude of current flowing through a neutral conductor of the GFCI. The electronic processor also compares a first voltage between the first phase conductor and neutral conductor to a second voltage between the second phase conductor and neutral conductor. A circuit breaker of the GFCI device is opened if a difference between the combined magnitude of phase conductor current and neutral conductor current exceeds a first threshold or a difference between the first voltage and second voltage exceeds a second threshold.
Patent WO-2021108605-A1 (WO)
Title: Composition et procédé de conversion de cellules gliales humaines en neurones
Inventor: CHEN GONG
IPC: A61K31/00
Filed: 2020-11-25
Abstract: L'invention concerne des compositions et des procédés de reprogrammation de cellules gliales en neurones. Le procédé implique l'utilisation d'une combinaison d'insuline et de forskoline pour générer des neurones. Les neurones peuvent être générés par conversion de cellules gliales en neurones. Les compositions et les procédés peuvent également comprendre l'un ou les deux parmi la vitamine C (VC) et le crizotinub (Cri). L'invention concerne également des articles manufacturés qui comprennent au moins une formulation pharmaceutique, un emballage et un matériau imprimé fournissant une indication et/ou une instruction pour utiliser les composés décrits.
Patent WO-2021108677-A1 (WO)
Title: Immunothérapie par cellules tueuses naturelles pour le traitement du glioblastome et d'autres cancers
Inventor: REZVANI KATY
IPC: C12N5/00
Filed: 2020-11-25
Abstract: Des modes de réalisation de l'invention concernent des méthodes et des compositions qui facilitent le traitement du cancer notamment au moins du fait qu'elles portent sur des thérapies qui entourent le microenvironnement tumoral. Dans des modes de réalisation spécifiques, des compositions sont utilisées pour une thérapie qui utilisent des cellules NK qui sont protégées de l'inhibition directe de leur activité (à l'aide d'inhibiteurs de TGF-bêta) et/ou qui sont indirectement protégées du TGF-bêta (à l'aide d'inhibiteurs de l'intégrine). Dans des modes de réalisation spécifiques, les cellules NK présentent une expression et/ou une activité déficientes pour le récepteur 2 du TGF-bêta et/ou le récepteur de glucocorticoïde.
Patent WO-2021113150-A1 (WO)
Title: Refinement of image segmentation
Inventor: ALVAREZ-VALLE JAVIER
IPC: G06T7/187
Filed: 2020-11-27
Abstract: A computer-implemented method comprising: receiving an image including an object depicted in the image; obtaining initial segmentation data defining segmentation of the image, the initial segmentation data comprising a first contour around the object; rendering the image and the first contour on a user display; providing a user-interface tool enabling a user to refine the first contour to define a refined line replacing a part of the first contour to thereby form a second contour around the object, wherein the user uses the tool to draw a user-drawn line on the rendered image and the refined line comprises at least the user-drawn line; and rendering the second contour on the image in place of the first.
Patent WO-2021127068-A1 (WO)
Title: Bcr transgenic mice with a common leader sequence
Inventor: BARNES RALSTON M
IPC: C12N15/10
Filed: 2020-12-17
Abstract: The present invention provides transgenic animals comprising some or all components of a human heavy and/or light chain immunoglobulin variable region locus, methods of making such animals, methods of making human antibodies using such animals, and methods of treatment using the human antibodies made in such animals, wherein the animals comprise in their genome a plurality of human heavy chain V gene segments all of which are immediately preceded by the same first leader peptide-encoding sequence, and/or a plurality of human light chain V gene segments all of which are immediately preceded by the same second leader peptide-encoding sequence, or both. The invention also provides polynucleotide constructs comprising two or more human heavy or light chain leader/V gene segments comprising identical leader peptide-encoding sequences. Such animals, constructs and methods find use in efficient generation of optimally diverse populations of antibodies against antigens of interest, such as antigens of therapeutic interest.
Patent WO-2021127361-A1 (WO)
Title: Gating energy consumption accumulation by detecting a fundamental component of a current
Inventor: STENBERG DAVID
IPC: G01R21/133
Filed: 2020-12-18
Abstract: Certain aspects and features include a system and method for energy measurement in electric meter systems. In an example, an electric meter receives an Alternating Current (A/C) signal. The electric meter includes a current measurement device that is configured to obtain a current measurement of a current of the A/C signal. The current measurement includes a fundamental frequency component and a noise component. The electric meter receives a current measurement signal from the current measurement device and filters the noise component from the current measurement, thereby creating a filtered current measurement signal. When the filtered current measurement signal is greater than a starting current threshold, the electric meter calculates an energy consumption measurement.
Patent WO-2021134022-A1 (WO)
Inventor: ARCHER MICHAEL
IPC: H04L29/08
Filed: 2020-12-24
Abstract: This disclosure provides embedding a messaging channel directly into a media stream, where messages delivered via the embedded messaging channel are the extracted at a client media player. An advantage of embedding a message is that it can be done in a single ingest point and then passes transparently through a CDN architecture, effectively achieving message replication using the native CDN media delivery infrastructure.
Patent WO-2020264582-A1 (WO)
Inventor: COLLINS CAROLINE
IPC: F17C1/16
Filed: 2020-06-29
Abstract: A corrugation is provided in a polymeric liner configured for inflation against a rigid shape. The polymeric liner has a cylindrical wall with opposing inner and outer surfaces. The liner includes a first liner section having a plurality of annular corrugations. Each of the corrugations has a curved mountain region with a ridge, a curved valley between adjacent spaced apart mountain regions, and a side wall joining each successive mountain region and valley. A distance between successive ridges defines a period of the corrugations. The wall thickness of the liner at the ridge is greater than the wall thickness at the valley. A radial distance between the ridge and the valley defines an amplitude of the corrugations. The amplitude is between about 0.65 times the period and about 0.75 times said period T of the corrugations.
Patent WO-2021154531-A1 (WO)
Title: Apparatuses, methods, systems, and techniques for improving the accuracy of internal combustion engine torque determinations
Inventor: BELLINGER STEVEN M
IPC: F02D41/14
Filed: 2021-01-19
Abstract: A system comprises a powertrain including an engine configured to output torque to a driveline, and an electronic control system operatively coupled with the powertrain. The electronic control system is configured to determine an engine torque value, and control a component of the driveline in response to the engine torque value. The engine torque value may account for an effect of air-fuel ratio (AFR) on engine torque. The engine torque value may account for an effect of charge transport delay on engine torque
Patent WO-2021155050-A1 (WO)
Title: Kinase modulators, pharmaceutical compositions, and therapeutic applications
Inventor: CHAN KYLE W H
IPC: C07D249/10
Filed: 2021-01-28
Abstract: Provided herein are kinase modulators,  e.g ., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with a protein malfunction.
Patent WO-2021188361-A1 (WO)
Title: Linear alpha-olefin copolymers and impact copolymers thereof
Inventor: LOPEZ-BARRON CARLOS
IPC: C08F4/6592
Filed: 2021-03-11
Abstract: This invention relates to a copolymer comprising about 50 wt% to about 99.9 wt% C 6 -C 60  linear α-olefin units; diene units; and optionally C 2 -C 10  α-olefin comonomer units different than the C 6 -C 60  linear α-olefin units. In at least one embodiment, the copolymer is crosslinked and the crosslinked copolymer has: a tensile set @200% deformation of about 0.1% to about 50% or less; a tensile strength at 40°C of about 50 kPa to about 1,000 kPa; about 1 kJ/m 3  to about 10 kJ/m 3 ; an elongation at break of about 10% to about 1,000%; a Young's modulus (at 40°C) of about 50 kPa to about 1,000 kPa; a glass transition temperature (Tg) of about -100°C to about 0°C; a melting temperature (Tm) of about 50°C to about 150°C; and a temperature of crystallization (Tc) of about 10°C to about 150°C.
Patent WO-2021183861-A1 (WO)
Title: Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
Inventor: KHALDOYANIDI SOPHIA
IPC: C07K16/28
Filed: 2021-03-12
Abstract: The present invention relates to medical combination products comprising (i) at least one antibody construct comprising at least one domain which binds to a target antigen expressed on the surface of a cell and at least one other domain which binds to CD3 as well as (ii) at least one molecule that is inhibitor / antagonist of TNF/ TNFR reducing TNF/TNFR signaling and/or an inhibitor / antagonist of IL6/IL6R that reduces IL6/IL6R signaling, wherein a first dose of said inhibitor / antagonist is administered before administration of a first dose of said antibody construct. Furthermore, the invention provides therapeutic and preventive methods and medical uses of said combination products, as well as a kit comprising said at least one antibody construct and at least one antagonist / inhibitor of TNF or IL6 or its cognate receptor, wherein the interaction of said antagonist / inhibitor of TNF or an inhibitor / antagonist of IL6 with its cognate receptor reduces, mitigates, prevents, or treats cytokine release syndrome.
Patent WO-2021195429-A1 (WO)
Title: Mise à niveau automatique de contenu vocal
Inventor: YEH CHUNGHSIN
IPC: H03G3/32
Filed: 2021-03-25
Abstract: La présente invention concerne, selon certains modes de réalisation, une mise à niveau automatique d'un contenu vocal. Dans un mode de réalisation, un procédé consiste : à recevoir, à l'aide d'un ou de plusieurs processeurs, des trames d'un enregistrement audio comprenant un contenu vocal et un contenu non vocal ; à déterminer, pour chaque trame, à l'aide du processeur ou des processeurs, une probabilité de parole ; à analyser, à l'aide du processeur ou des processeurs, une sonie perceptuelle de la trame ; à obtenir, à l'aide du processeur ou des processeurs, une plage de sonie cible pour la trame ; à calculer, à l'aide du processeur ou des processeurs, des gains à appliquer à la trame en fonction de la plage de sonie cible et de l'analyse de sonie perceptuelle, les gains comprenant des gains dynamiques qui changent trame par trame et qui sont mis à l'échelle en fonction de la probabilité de parole ; et à appliquer les gains à la trame de telle sorte qu'une plage de sonie résultante du contenu vocal dans l'enregistrement audio soit comprise dans la plage de sonie cible.
Patent WO-2021202420-A1 (WO)
Title: Universal home testing system for infectious diseases
Inventor: MILLER AGUSTIN RUIZ
IPC: G16H10/40
Filed: 2021-03-29
Abstract: A device and system used to enhance at-home medical test kits so that it provides the ability for a third-party system to capture test results, interacted contacts and other valuable information such as symptoms experienced. The goals are to provide the captured information to health authorities, medical partners and use it to execute contact tracing.
Patent WO-2021202835-A1 (WO)
Title: Automatic packager for medications
Inventor: ARSENAULT AARON
IPC: A61J7/00
Filed: 2021-04-01
Abstract: An automatic blister card packager (200) is provided. The automatic blister card packager (200) includes a universal feed cassette (205) for individually dispensing medications, a packaging unit (210) in communication with the universal feed cassette (205). The packaging unit (210) is configured to receive a blister card (100). The automatic blister card packager 210 also includes a chute (230) connecting the universal feed cassette (205) to the packaging equipment (210). The chute (230) includes a plurality of tracks (450) and directs the medications dispensed from the universal feed cassette (205) into the blister card (100) received in the packaging equipment (210).