baber/WOPTO huggingface dataset:
Patent CA-2443323-A1 (CA)
Inventor: CHANG GWONG-JEN J
IPC: C12N15/40
Filed: 2002-04-04
Abstract: L'invention concerne des acides nucléiques isolés contenant des unités transcriptionnelles codant pour une séquence signal d'un flavivirus et un antigène de flavivirus immunogène d'un second flavivirus ou d'un antigène de flavivirus immunogène chimérique comprenant une séquence de plus d'un flavivirus. L'invention concerne également un vaccin d'acide nucléique et de protéine, ainsi que l'utilisation de ce vaccin pour immuniser un sujet contre des infections à flavivirus. Cette invention concerne également des antigènes codés par les acides nucléiques de cette invention, des anticorps produits en réponse à ces antigènes, ainsi que l'utilisation de ces antigènes et/ou anticorps pour la détection de flavivirus ou le diagnostic d'une infection à flavivirus.
Patent CA-2444622-A1 (CA)
Inventor: COOPER DAVID
IPC: A61C19/00
Filed: 2002-03-28
Abstract: L'invention concerne une station d'accueil universelle (100) conçue pour un cabinet dentaire et permettant de gérer une pluralité de sous-systèmes d'imagerie traités numériquement. Ces sous-systèmes comprennent des caméras vidéo (102) pour imagerie intra-buccale ou extra-buccale, des microscopes de vidéochirurgie (104), des unités d'analyse de film radiographique (106), des rayons x numériques (108) et tout autre type de système d'imagerie qui produit un vidéo S, une sortie de signal vidéo numérique ou vidéo composite. La station d'accueil universelle (100) peut apporter aux sous-systèmes d'imagerie des fonctionnalités d'exploitation, telles que de la puissance, de la lumière et des instructions pour commander l'opération du sous-système. La station d'accueil universelle (100) reçoit des signaux de sortie de chaque sous-système d'imagerie pour afficher, traiter, enregistrer et/ou pour d'autres utilisations. Ce système d'accueil universel (100) fournit des interfaces permettant de sélectionner et de faire fonctionner divers systèmes périphériques tels que des écrans (112), des ordinateurs (114), des multiplexeurs (118) ou des imprimantes (120) et de commander numériquement des images à partir des sous-systèmes d'imagerie.
Patent CA-2445159-A1 (CA)
Title: Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
Inventor: BUCHWALD STEPHEN L
IPC: C07D273/08
Filed: 2002-04-24
Abstract: The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to cooper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.  In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.
Patent CA-2446217-A1 (CA)
Title: Systeme et methode pour la reparation de revetement a haute temperature sur un revetment durci
Inventor: BALATAN SERGIO
IPC: C09D133/08
Filed: 2002-07-17
Abstract: La présente invention concerne une composition de couche primaire qui comprend un polymère acrylique préparée à partir d'une combinaison de monomères comprenant au moins environ 30% en poids d'acrylate d'éthyle, d'acrylate de méthyle, de méthacrylate de méthyle ou d'une combinaison de ceux-ci. Cette composition de couche primaire peut aussi comprendre une combinaison de résine de mélamine méthylée et une résine de mélamine butylée. Une couche partiellement durcie au moins de cette composition de couche primaire présente une adhésion améliorée avec une couche de composition de revêtement appliquée sur celle-ci et durcie, que cette couche de composition de revêtement appliquée soit une autre couche de cette composition de couche primaire ou une couche de composition de vernis incolore.
Patent CA-2447008-A1 (CA)
Inventor: ASHLEY ROBERT A
IPC: A61K9/22
Filed: 2002-04-05
Abstract: La présente invention concerne une composition destinée à la délivrance d'un composé de tétracycline à un mammifère. La composition comporte un composé de tétracycline antibiotique et un agent de libération contrôlée présentant au moins un agent à libération contrôlée. Le composé de tétracycline est associé à une matrice à libération contrôlée pour fournir un profil de libération grâce auquel le mammifère est traité sensiblement sans activité antibiotique. L'invention concerne également des procédés de traitement d'un mammifère à l'aide un composé de tétracycline et une unité posologique mettant en oeuvre la composition de tétracycline à libération contrôlée.
Patent CA-2448194-A1 (CA)
Title: Oral fluid collection device and collection method
Inventor: SANGHA JANGBIR
IPC: A61B10/00
Filed: 2002-05-16
Abstract: An apparatus is provided for oral fluid collection from the mouth the apparatus having a fluid resistant shield adjacent one portion or side of the absorbent to support the absorbent after the absorbent is moist with oral fluid and the shield further operating to block the collection or mucosal transudate from the gum and teeth margin. A method of collection saliva while excluding the collection of mucosal transudate is provided wherein blocking of a portion of an absorbent is performed and the blocked portion of the absorbent is placed adjacent the teeth and gums to exclude any direct collection of mucosal transudate.
Patent CA-2448899-A1 (CA)
Title: A short synthesis of pyridine-based pharmaceutical intermediates with sulfur-containing groups at the 2- and 3-positions
Inventor: HUANG SHENLIN
IPC: C07D213/70
Filed: 2002-05-30
Abstract: A method of making a compound of Formula VI:wherein Tr is a triphenyl group; R1, R2 and R3 are each independently selected from the group consisting of H , C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, and arylalkyl; R4 is C2-C6 alky l, and R5 and R6 are each independently H or C1-C4 alkyl, involves the step of reacting a compound of Formula V: with Tr-OH to produce a compound of Formul a VI. The compounds of Formula VI are useful as intermediates in the manufactu re of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.</SD OAB>
Patent CA-2450871-A1 (CA)
Inventor: PARNIAK MICHAEL
IPC: C12Q1/68
Filed: 2002-07-26
Abstract: L'invention concerne un procédé permettant de mesurer l'hétérodimérisation de la TI du VIH. Ce procédé comprend les étapes suivantes : a) on prépare une première solution comprenant des homodimères de la sous-unité p66 en présence d'un agent de dissociation, b) on met en contact cette première solution avec des sous-unités de TI p51, et on incube ce mélange en présence d'un tampon de réassociation afin de permettre la formation d'un complexe des sous-unités TI p66/p51, l'une de ces sous-unités comprenant un marqueur d'affinité et l'autre sous-unité comprenant un marqueur détectable, c) on fait entrer en contact le produit d'incubation obtenu à l'étape b) avec un support d'affinité dans des conditions permettant la liaison du complexe p66/p51 avec le support d'affinité, et d) on détermine la quantité de complexe formé en mesurant le niveau de marqueur détectable lié avec le support d'affinité (ou en mesurant l'activité polymérase de la TI reconstituée). Les étapes a) à d) peuvent être effectuées éventuellement en présence d'un composé d'essai, et sont suivies, le cas échéant, d'une étape e) consistant à comparer l'échantillon de composé d'essai avec un échantillon témoin ne contenant pas ce composé. La formation d'un complexe p66/p51 modulé dans l'échantillon contenant composé d'essai donne une indication de la capacité du composé à moduler, à inhiber ou à stimuler l'hétérodimérisation. Ce procédé peut être utilisé pour un criblage permettant l'identification d'inhibiteurs de la dimérisation de la TI du VIH.
Patent CA-2451635-A1 (CA)
Title: Improved breast electrode array and method of anaylysis for detecting and diagnosing diseases
Inventor: SAFAEE-RAD REZA
IPC: A61B5/053
Filed: 2003-12-01
Abstract: This invention provides for an improved breast electrode array and method of analysis for detecting and diagnosing diseases, particularly using the improved electrode array of this invention. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. In one aspect of the invention, at least one of the outer electrodes is spaced from the body greater than the other outer electrodes. In a further aspect of the invention, at least one of the inner electrodes is spaced from the body greater than the other inner electrodes, and the at feast one inner electrode is provided on the flexible arm having the at least one outer electrode.      A number of diagnostic methods based on homologous electrical difference analysis are also disclosed utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
Patent CA-2452407-A1 (CA)
Title: Preparation of polymer particles
Inventor: KILAAS LARS
IPC: C08F2/32
Filed: 2002-07-04
Abstract: A process for the preparation of polymer magnetic particles, which comprises:  (a) providing a water phase containing magnetic components homogeneously dispersed therein; (b) wherein the water phase is contacted with or further contains a polymerisable metal-containing or organic monomer which is soluble in the water phase; and (c) polymerising the monomer in the presence of the magnetic in which the magnetic components are substantially uniformly distributed; wherein at least a part of the polymerising step (c) is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogeneously dispersed therein is present as a discontinuous phase in a continuous oil phase.
Patent CA-2452929-A1 (CA)
Inventor: AHAD ASMA
IPC: A23L11/00
Filed: 2003-12-15
Abstract: This invention relates to simulated nut production. More specifically, it relates to a method for producing a simulated nut, said method comprising providing a premix by mixing soy bean particles having surfaces, a nut flavoring, and a binder comprising a saccharide in a wet flowable form wherein the surfaces of the soy bean particles are coated with the binder, and forming the premix into a self-supporting shape that is substantially similar to a natural nut shape. The resulting simulated nut product is healthier due to the substantial soy content used instead of real nutmeat, while replicating authentic nut flavor, crunch, appearance, texture, and the like. The simulated nuts of the present invention can be made at less cost than obtaining real nuts.
Patent CA-2455125-A1 (CA)
Inventor: MOORE SCOTT T
IPC: A61F2/04
Filed: 2002-07-30
Abstract: Disclosed is a pressure sensitive prosthesis that includes a tubular member (11) having a passageway (12) extending therethrough and a sleeve (13) attached about one end (14) of the tubular member (11). The sleeve (13) functions as a one-way valve to permit fluid flowing through the sleeve lumen in a first direction (17) and under a first pressure, while collapsing in response to fluid flowing in a second direction (18) when the pressure thereof exceeds that of the first direction or pressure. One aspect of the invention includes an esophageal anti-reflux expandable prosthesis wherein the sleeve (13) is adapted to invert back through the tubular stent frame (11) to permit belching or vomiting (fluid or materials under a third, significantly higher pressure). Another aspect of the invention includes a tubular drainage stent, such as a biliary or urethral stent in which the sleeve (13) opens to permit passage of fluids, then collapses to prevent retrograde flow.
Patent CA-2455240-A1 (CA)
Inventor: JOHNSON LAWRENCE WESLEY
IPC: A63B71/02
Filed: 2004-01-15
Abstract: In the game, missiles are pitched by hand at a target. The target is in the form of an enlarged bottle-cap, which resides on top of a bottle. The bottle is secured in the centre of a bowl. The missiles are identical to the enlarged cap.
Patent CA-2458858-A1 (CA)
Title: Pneumatic tire with sidewall projections
Inventor: YOUNG JOHN E
IPC: B60C11/11
Filed: 2002-08-02
Abstract: A pneumatic tire has an aggressive tread pattern for use on both on-road and off-road vehicles having at least a pair of intermediate ribs and a pair of shoulder ribs providing the ground engaging tread lugs. A plurality of circumferentially extending lug groups are formed on and extend outwardly form and along the sidewalls of the tire. Each lug group preferably includes three separate lugs, each lug having a substantially flat oute surface lying in a different plane than the outer surfaces of the other two lugs. Two of the lugs are radially aligned with each other along the sidewall of the tire with the third lug lying intermediate spaced pairs of these aligned lugs. The lugs are formed with sharp corners offset from each other which extend outwardly from the sidewall to different levels. A top surface of one of the lugs aligns with the ground engaging surface of an adjacent shoulder rib tread lug and the top surface of the intermediate lug aligns with the inner tread surface of the road engaging tread pattern.
Patent CA-2460198-A1 (CA)
Title: Hydroxy-functional esters having terminal acrylate groups
Inventor: DETTLOFF MARVIN L
IPC: C08F2/46
Filed: 2002-09-10
Abstract: The present invention provides hydroxy-functional esters having at least one terminal acrylate-functional group. Preferred esters include those represented by the following formula (1):wherein each R1~ independently represents a substituted or unsubstituted aliphatic group; R represents hydrogen or methyl;  a represents an integer of O to 5 ; b represents an integer of 0 to 5 ; a+b =  at least 1 ; c represents an integer of O to 3; and A represents an alkylene, heteroalkylene, or arylene segment.
Patent CA-2462731-A1 (CA)
Inventor: CUYPERS HERVE JOSEPH GISLAIN
IPC: C08J9/16
Filed: 2002-10-17
Abstract: L'invention concerne l'utilisation d'une composition à base de polypropylène (C) comprenant (a) entre 5 et 95% en poids d'un copolymère aléatoire de propylène (A) contenant entre 0,5 et 12% molaires d'au moins un comonomère choisi parmi un éthylène et/ou une alpha-oléfine renfermant entre 4 et 6 atomes de carbone, et présentant une valeur MFI<SB>A</SB> comprise entre 0,01 et 5 g/10 min, et (b) entre 95 et 5% en poids d'un copolymère aléatoire de propylène (B) contenant entre 0,5 et 12% molaires d'au moins un comonomère choisi parmi un éthylène et/ou une alpha-oléfine renfermant entre 4 et 6 atomes de carbone, et présentant une valeur MFI<SB>B</SB> comprise entre 15 et 1000 g/10 min. Ladite composition (C) se caractérise en ce que les copolymères aléatoires (A) et (B) contiennent le ou les mêmes conomomères et présentent sensiblement la même teneur en comonomère pour chaque comonomère. Elle est utile dans la fabrication de perles expansées.
Patent CA-2464940-A1 (CA)
Inventor: MORGAN ANDREW JOHN
IPC: C12N9/02
Filed: 2002-10-30
Abstract: The present invention discloses sequence information relating to pyranosone dehydratase. The invention further relates to the use of pyranosone dehydratase in the conversion of AF to APP and microthecin and the conversio n of glucosone to cortalcerone.
Patent CA-2466508-A1 (CA)
Title: Method and pharmaceutical preparations for reducing the activity of cells
Inventor: SHARONI YOAV
IPC: A61K31/015
Filed: 2002-11-05
Abstract: A method for reducing the activity of a cancer cell, comprising administerin g to a subject in need thereof a composition comprising of lycopene and an additional caroteniod.
Patent CA-2469809-A1 (CA)
Inventor: DE JONG JOHANNES H A
IPC: A61F13/02
Filed: 2001-12-21
Abstract: A continuous process for manufacturing a multilayered wound dressing (10) including an apetured wound contact layer (13), an absorbent material layer (12), and a backing layer (11). The process includes providing a substantial ly continuous first web (19) including layer (13) and a first process lelease liner (15),forming a plurality of apetures (14) through layer (13), applying layer (12) to layer (13), laminating a sbstantially continuous web of layer (11) over layer (12) to form a composite web, and cutting individual multilayered dressing (10) from the composite web.
Patent CA-2470056-A1 (CA)
Title: Label ledge for injection molded containers
Inventor: GRAHAM BRIAN K
IPC: B29C49/06
Filed: 2002-12-23
Abstract: An improved in mold label for use in labeling products made by injection, or other, molding technologies has a zig-zag shaped edge cut contained in a registration area which contains ink that matches the product resin. At leas t one ledge is formed in a cavity wall of the mold proximate the position intended for receipt of an in mold label. The ledge protects the leading edg e of the in mold label from the flow of resin through the cavity walls of the mold. Because the label leading edge is protected, the resin flows over the label and pins the label to the cavity wall of the mold, creating a containe r with the label formed on the container wall. Alternatively, a container lid is provided with a ledge to facilitate skirting and label placement on the pan area of the lid. These features both enhance the structural integrity and th e uniform unblemished appearance of the finished molded container. Because of the enhanced structural integrity, high melt resin may be used to create the container, reducing the cycle time, and thus the cost of the product. The la ck of blemishes in the finished container reduces manufacturing waste.
Patent CA-2472309-A1 (CA)
Inventor: CASPER ROBERT F
IPC: A61K38/24
Filed: 2001-04-17
Abstract: Procédé permettant d'induire une ovulation chez une femme atteinte de stérilité anovulatoire, consistant à administrer à cette femme une ou plusieurs doses quotidiennes d'au moins un inhibiteur de l'aromatase. Procédé pour augmenter l'ovulation chez une femme ovulant atteinte d'une stérilité inexpliquée ou d'un autre type de stérilité ovulatoire, consistant à administrer à cette femme au moins deux doses quotidiennes d'au moins un inhibiteur de l'aromatase au début d'un ou de plusieurs cycles menstruels. Procédé pour réduire sensiblement les doses d'hormone folliculostimulante (FSH) à administrer à une femme suivant un traitement contre la stérilité, consistant à administrer une combinaison d'au moins deux doses quotidiennes d'au moins un inhibiteur de l'aromatase (AI) avec plusieurs doses quotidiennes d'hormone folliculostimulante (FSH). Procédé pour augmenter la réponse à une hormone folliculostimulante chez une femme répondant peu à la stimulation folliculaire, consistant à administrer une combinaison d'au moins deux doses quotidiennes d'au moins un inhibiteur de l'aromatase (AI) avec plusieurs doses quotidiennes d'hormone folliculostimulante (FSH). L'invention concerne également des préparations pharmaceutiques et des utilisations associées.
Patent CA-2478407-A1 (CA)
Title: Polyvinyl acetate film coatings with controlled release and high stability
Inventor: KOLTER KARL
IPC: A61K9/32
Filed: 2003-03-11
Abstract: The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which agents are released in a controlled manner, and methods for the production thereof. The controlled-release properties can be specifically adjusted by means of said combinations, resulting in films having excellent mechanical stability and storage stability. In particular, agents are released independent of the pH by means of the inventive forms of administration.
Patent CA-2481401-A1 (CA)
Title: Antibodies that specifically bind to tl5
Inventor: RUBEN STEVEN M
IPC: C07K16/28
Filed: 2003-04-10
Abstract: The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejectio n, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti~TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragmen ts or variants thereof, or related molecules, that specifically bind to TL5.</S DOAB>
Patent CA-2483508-A1 (CA)
Title: Cable safety system
Inventor: BERGENDAHL PETER
IPC: E01F15/06
Filed: 2003-05-23
Abstract: A safety system including cables and support posts is provided. The safety system may be used to prevent vehicles from impacting with an associated roadside hazard. The safety system will typically maintain engagement between associated cables and support posts for a longer period of time as the posts are bent during a vehicle impact.
Patent CA-2484130-A1 (CA)
Title: Ultrasensitive spectrophotometer
Inventor: LARSEN DAVID W
IPC: G01J3/42
Filed: 2003-04-04
Abstract: One aspect of the invention is a spectrophotometer detection circuit (189, 934, 1031). In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams.  Both voltages are available to allow simultaneous measurement and analysis.  Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing (112, 900, 1000) and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing (900, 1000) with a hollowed portion (900a, 1000a) defined to mount and place optical system components.  Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments.