Patent SG-11201806166W-A (SG)
Title: Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
Inventor: COOPER IAN
IPC: C07D263/58
Filed: 2017-02-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/137744 Al 17 August 2017 (17.08.2017) WIPO I PCT 1111111111111101110111111111110101111101110111011111101110111111111111111111110111111 (51) International Patent Classification: A61P 31/04 (2006.01) CO7D 263/58 (2006.01) A61P 31/06 (2006.01) A61K 31/423 (2006.01) (21) International Application Number: PCT/GB2017/050318 (22) International Filing Date: 8 February 2017 (08.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1602241.0 8 February 2016 (08.02.2016) GB 1616460.0 28 September 2016 (28.09.2016) GB (71) Applicant: REDX PHARMA PLC [GB/GB]; Block 33F, Mereside, Alderley Park, Alderley Edge Cheshire SK10 4TG (GB). (72) Inventors: COOPER, Ian; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). LYONS, Amanda; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). ORR, David; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). KIRKHAM, James; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alder- ley Edge, Cheshire SK10 4TG (GB). BLADES, Kevin; c/o Red Pharma PLC, Block 33 F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). (74) Agents: HGF LIMITED (LEEDS) et al.; 1 City Walk, Leeds West Yorkshire LS11 9DX (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 171377 / 44 Al (54) Title: HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DE- RIVATIVES, AND THEIR USE AS ANTIBACTERIAL COMPOUNDS (57) : This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the compounds in treating bacterial infections and in methods of treating bacterial infections.