Patent SG-11201906441Y-A (SG)
Title: A modified alginate copolymer, alginate nanoparticle and applications thereof
Inventor: KUMAR JATIN
IPC: A61Q11/00
Filed: 2018-01-22
Abstract: IRA! I I'on ionalriation taiga MA urf ck Fig. 2b (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit VIII °nolo 01110111010 0111 omoiliflo oimIE (10) International Publication Number WO 2018/136012 Al (51) International Patent Classification: CO8F 251/00 (2006.01) A61K 8/73 (2006.01) CO8B 37/00 (2006.01) A61Q 19/02 (2006.01) CO8L 5/04 (2006.01) A61Q 11/00 (2006.01) A61K 47/36 (2006.01) A61P 35/00 (2006.01) A61K 47/34 (2017.01) (21) International Application Number: PCT/SG2018/050037 (22) International Filing Date: 22 January 2018 (22.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201700470R 20 January 2017 (20.01.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventor: KUMAR, Jatin; c/o Institute of Materials Research & Engineering, 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, — (54) Title: A MODIFIED ALGINATE COPOLYMER, ALGINATE NANOPARTICLE AND APPLICATIONS THEREOF O 00 O C (57) : There is provided a modified alginate copolymer comprising an alginate backbone and having a grafted moiety attached to one of the hydroxyl groups of the alginate backbone, the grafted moiety comprising a polymer and a stabilizing group, the stabilizing group comprising at least 2 heteroatoms independently selected from the group consisting of N, S, P and Si. In a preferred embodiment, poly(ethylene glycol)methyl ether methacrylate is grafted onto alginate macroRAFT polymerization or 'click' Chemistry approach. via There is provided a drug delivery method using the cation -mediated self-assembly of modified alginate copolymer as defmed herein. There is provided a process to make the modified alginate copolymer as defined herein. There are further provided cosmetic applications and medical applications of the modified alginate copolymer as defmed herein. [Continued on next page] WO 2018/136012 Al MIDEDIMOMOIDEIREEMOMMIMINIRMiln011 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE