Patent SG-11201811448R-A (SG)
Title: Dihydropyranopyrimidines for the treatment of viral infections
Inventor: JONCKERS TIM
IPC: C07D491/052
Filed: 2017-06-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) W I PO I PCT °mons °nolo olo lionll ounio imio oimIE (10) International Publication Number WO 2018/002319 Al (51) International Patent Classification: CO7D 491/052 (2006.01) A61P 37/04 (2006.01) A61K 31/505 (2006.01) (21) International Application Number: PCT/EP2017/066307 (22) International Filing Date: 30 June 2017 (30.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16177401.3 01 July 2016 (01.07.2016) EP (71) Applicant: JANSSEN SCIENCES IRELAND UC [IE/IE]; Eastgate Village, Eastgate Little Island, Co Cork (IE). (72) Inventors: JONCKERS, Tim, Hugo, Maria; c/o Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). RABOISSON, Pierre, Jean-Marie, Bernard; c/o Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). GUILLEMONT, Jerome, Emile, Georges; c/o Janssen- Cilag, 1 rue Camille Desmoulins, TSA 91003, 92787 Issy- les-Moulineaux Cedex 9 (FR). MC GOWAN, David, Craig; c/o Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). EMBRECHTS, Werner, Con- stant, Johan; c/o Janssen Pharmaceutica NV, Turnhout- seweg 30, 2340 Beerse (BE). COOYMANS, Ludwig, Paul; c/o Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). CALMUS, Laurent; c/o NovAliX SAS BioParc, Boulevard Sebastien Brant, BP 30170, 67405 Il- lkirch Cedex (FR). (74) Agent: DAELEMANS, Frank; Johnson & Johnson, Turn- houtseweg 30, 2340 Beerse (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, 1-1 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, M UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, O O EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art. 21(3)) 1-1 (54) Title: DIHYDROPYRANOPYRIMIDINES FOR THE TREATMENT OF VIRAL INFECTIONS \" (57) : This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compo- C sitions, and their use in treating viral infections.