baber/WOPTO huggingface dataset:
Patent EA-201992755-A1 (EA)
Title: Новые моноклональные антитела к белку 4, ассоциированному с цитотоксическими т-лимфоцитами, (ctla-4)
IPC: C12N15/13
Filed: 2017-05-19
Abstract: Настоящее изобретение относится к моноклональным антителам CTLA-4, в частности к гуманизированным моноклональным антителам, специфически связывающимся с CTLA-4 с высокой аффинностью. Настоящее изобретение также относится к функциональным моноклональным антителам, перекрестно-реактивным с CTLA-4 человека, яванской макаки и мыши. Настоящее изобретение также относится к аминокислотным последовательностям антител по изобретению, клонирующим или экспрессирующим векторам, клеткам-хозяевам и способам экспрессии или выделения антител. Эпитопы антитела идентифицированы. Также предложены терапевтические композиции, содержащие антитела по изобретению. Изобретение также относится к способам лечения злокачественных новообразований и других заболеваний с использованием антител против CTLA-4.
Patent EA-202090470-A1 (EA)
Title: Композиция для личного ухода
IPC: A61K8/49
Filed: 2018-07-09
Abstract: Настоящее изобретение относится к композиции для личного ухода, содержащей комбинацию 1-пиперидинпропионовой кислоты и пиридинкарбоксамида. Композиция обеспечивает синергетическое осветление кожи.
Patent EA-202091930-A1 (EA)
Title: Макроциклы в качестве модуляторов муковисцидозного трансмембранного регулятора проводимости, их фармацевтические композиции, применение их для лечения муковисцидоза и способ их изготовления
IPC: A61P11/00
Filed: 2019-02-14
Abstract: Раскрыты соединения формулы (I)их фармацевтически приемлемые соли, дейтерированные производные любого из вышеперечисленных и метаболиты любого из вышеперечисленных. Также раскрыты содержащие их фармацевтические композиции, способы лечения муковисцидоза с их применением и способы их изготовления.
Patent EA-202190262-A1 (EA)
Title: Способ тестирования иммунологической толерантности у животных
IPC: G01N33/536
Filed: 2021-02-12
Abstract: Изобретение относится к ветеринарной иммунологии, которое может быть использовано в клинической практике для диагностики иммунологической толерантности у животных, в частности к способу оценки иммунологической ареактивности в биологической системе "мать-плод-новорожденный" и использовать иммунологические методы диагностики для выявления различных заболеваний у сельскохозяйственных животных на крупных и мелких животноводческих фермах. Сущность способа тестирования иммунологической толерантности у животных заключается в следующем: производят иммунизацию производителей их же семенем, а затем ставят реакцию агглютинации семени с сывороткой крови потомства в разведении 1:50-1:100, а по степени схожести белков соматических клеток крови и семени устанавливают степень толерантного состояния иммунной системы. Проводят забор от проверяемого производителя семя и накапливают его путем глубокого замораживания в жидком азоте. Для иммунизации семя центрифугируют, осадок сперматозоидов трехкратно промывают физиологическим раствором и снова центрифугируют. Осадок разводят физиологическим раствором в соотношении 1:1 и вводят производителю подкожно. После чего осуществляют оценку выполненной реакции и устанавливают прогноз иммунологической толерантности новорожденного организма.
Patent EA-202191995-A1 (EA)
Title: Циклические молекулы в качестве ингибитора тирозинкиназы брутона
Filed: 2020-01-16
Abstract: Изобретение относится к новой молекуле с активностью ингибирования протеинтирозинкиназы, а также к ее синтезу и применению. В частности, настоящее изобретение относится к соединению формулы A, его фармацевтически приемлемым солям, гидратам или сольватам, а также к его синтезу и применению.
Patent EA-202192153-A1 (EA)
Title: Ингибиторы для терапевтического применения
Filed: 2020-03-04
Abstract: Настоящее изобретение относится к ассоциации ингибиторов активности по меньшей мере одного белка, принадлежащего к семейству Hsp70, и ингибиторов активности GRP78 для применения в лечении резистентности к инсулину и/или патологий, возникающих вследствие этого клинического состояния.
Patent ES-2223234-A1 (ES)
Title: Rotary displaceable inspection stand for e.g. glass includes immobilizer frame wtih electrical controls and guides
Inventor: ALVAREZ PELAEZ LUIS MIGUEL
IPC: C03B35/20
Filed: 2002-08-09
Abstract: The rotary displaceable inspection stand for e.g. glass has a frame immobilizing the material being inspected, with a locator and 180[deg] angle displacer system. A vertical guide and control buttons supplement an electrical control assembly.
Patent ES-2214120-A1 (ES)
Title: Digital oscilloscope, has analog part, digital part, power supply and external trigger block provided in plate, and two controllers connected with filters, where digital part is directly connected to personal computer
Inventor: MOYA ALBACETE DANIEL
IPC: G01R13/22
Filed: 2002-11-26
Abstract: The oscilloscope has an analog part (10), a digital part (20), a power supply (30) and an external trigger block (2) provided in a plate (1). Two controllers are connected with filters, and the digital part is directly connected to a personal computer (PC). The analog part comprises a channel-A and a channel-B, which are formed by selecting an alternating current (AC) block and a direct current (DC) block. The digital part maintains communication with a peripheral component interconnect (PCI)bus of the PC via a PCIbus controller.
Patent ES-2237258-A1 (ES)
Title: Machine for removing floating refuse from the surface of water
Inventor: GALAN CAVADAS JESUS
IPC: E02B15/04
Filed: 2003-02-27
Abstract: Machine for removing floating refuse from the surface of water. The invention relates to a machine for removing floating refuse from the surface or water, which can be used to remove both solid floating refuse (tar, crude oil and plastics) and liquids floating refuse (oils and fats) from the surface of the sea, rivers and lakes. The inventive machine consists of a structure (1), comprising an endless conveyor belt (2) and a wheel (3) with paddles (21) which strike the water. Said machine is fixed to the side of a boat (20) such that the end thereof nearest the bow is immersed in the water (20 or 30 cm), said end comprising a filter-comb (18), while the end thereof nearest the stem is suspended at a height, said end comprising a brush-roller (11). In addition, a hopper (4) is provided which is inclined toward the interior of the boat in order to collect the refuse. According to the invention, the fixed pinion (5) of the above-mentioned wheel (3) meshes with the fixed double pinion (6) of the roller closest to the shaft (13). Moreover, a chain (7) connects said fixed double pinion (6) with the fixed double pinion (8) of the roller at the upper end of the belt (2). The fixed double pinion (8) of the upper roller meshes with a second pinion (not fixed) (9) and the latter meshes with a third fixed pinion (10) the shaft of which supports the brush-roller (11).
Patent ES-2251278-A1 (ES)
Title: Orthotic knee joint
Inventor: BARBERA GUILLEN RICARD
IPC: A61F5/01
Filed: 2003-10-07
Abstract: The invention relates to an orthotic knee joint. The inventive orthosis reproduces the physiological curve of the knee such as to correspond perfectly with the variation in the instantaneous axis of rotation of same. The invention is based on a mechanism comprising four bars with a degree of freedom, which can be used to vary the position of the axis of rotation of the orthosis. According to the invention, the lower part (4) of the orthosis serves as a fixed reference, while the upper part (1) thereof serves as a follower. The orthosis further comprises cams (2 and 3) which are used to transmit changes from the upper part (1) to the lower part (4) thereof.
Patent ES-2246167-A1 (ES)
Title: Pigment preparation for colouring polymers
Inventor: CASTANYER COLLELL JOSEP
IPC: C08L33/04
Filed: 2004-07-27
Abstract: This includes one or more pigment mixtures and a carrier. The carrier has an oligomer or a combination of low molecular weight polymers from the group including Ethylene acrylic acid polymers and copolymers, Ethylene maleic anhydride polymers and copolymers or Anhydride maleic polypropylene polymers and copolymers. The carrier also has a polymer from the group including Ethylene acrylic ethyl, Ethylene/acrylate butyl, Ethylene/methacrylate acid, polypropylene grafted with methyl polymethacrylate, Polypropylene with grafted polystyrene or copolymers in a styrene block. For organic pigments, the preparation is between 50%-70% pigment and 50-30% carrier. For inorganic pigments it is between 60-90% pigment and 40-10% carrier. A multipurpose pigment preparation is obtained which can be used to manufacture highly accurate colour concentrates with specific bases.
Patent ES-2324128-A1 (ES)
Title: Molecular markers of hepatocellular carcinoma and their applications
Inventor: CORRALES IZQUIERDO FERNANDO
IPC: G01N33/574
Filed: 2005-09-29
Abstract: By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A-/-) have been identified for the MAT1A gene (deficient in the synthesis of S-adenosylmethionine). 27 proteins have been detected the expression thereof is altered in, at least, 50% of the analysed tumours. Amongst them, 13 proteins have been validated in biopsies of patients with HCC of different etiology, and 7 of them have been validated in biopsies of patients with liver cirrhosis, a stage prior to the development of HCC, which makes it possible to differentiate between prior stages of the disease and even between different etiologies (viral and alcoholic). Having a panel of markers available may contribute to more accurately defining the alterations associated with the development of HCC and thus facilitate prognosis and diagnosis of this disease.
Patent ES-2300193-A1 (ES)
Title: Method for the in vivo measurement of the alignment of the optical components of the eye and device for implementing same
Inventor: TABERNERO DE PAZ JUAN FRANCISC
IPC: A61B3/10
Filed: 2006-07-06
Abstract: The invention relates to a method for the in vivo measurement of the alignment of the optical components of the eye and to a device for implementing same. According to the inventive method, a light source (1) is used to illuminate the patient's eye while the head is maintained duly stable and the patient looks towards a fixed point (3), such that a camera (4-14) records the Purkinje images (PI, PIII and PIV) reflected in the eye for different pre-established known angular positions. The angular position in which the PIII and PIV Purkinje images overlap is then calculated using the images obtained and interpolation and extrapolation, thereby locating the optical axis of the intraocular lens. The distance from the point of overlap to the entrance pupil provides the offsetting value of the desired lens. Next, the physiological angle by which the eye is rotated is calculated from the misalignment between the PI Purkinje image and the centre of the pupil. Finally, the value of the inclination of the lens is calculated using the values of the angular position in whcih the PIII and PIV images overlap, the offsetting value of the lens and the kappa angle.
Patent ES-2319713-A1 (ES)
Title: Device for separating the stalks of fruit, grouped together in clusters, from one another
Inventor: BLANC PHILIPPE
IPC: A23N15/02
Filed: 2007-04-04
Abstract: Device for separating the stalks of fruit such as cherries, grouped together in clusters, from one another at their joining point, includes at least one hydraulic circuit including a tank ( 1 ) receiving the fruit to be treated a centrifugal pump ( 2 ) connected to the tank for sucking up the liquid and the fruit therefrom and at least one filtration device ( 3 ) receiving the liquid and the fruit discharged by the pump and capable of separating the fruit from the liquid. The tank has a base ( 4 ) which converges downwards as far as a lower outlet orifice ( 5 ) of this tank. The pump includes a housing ( 7 ) and at least one pumping wheel ( 9 ) guided in rotation relative to the housing along an at least substantially vertical axis ( 10 ) of rotation, and the pump has an axial suction inlet ( 11 ) connected below the lower outlet orifice.
Patent ES-2324385-A1 (ES)
Title: Device and method for controlling toasting and baking
Inventor: SANCHEZ-PRIETO ALER ENRIQUE
IPC: A47J37/08
Filed: 2008-02-04
Abstract: Device for controlling toasting and baking that comprises, at least: means (1) for sensing toasting, such that the degree of toasting is detected as a function of the shade thereof means (2) for processing the signal emanating from the sensing means (1) logic processing and control means (3) logic storage means (4) and a plurality of toasting means (5) wherein all the components are connected to the logic processing and control means (3), thereby enabling a method for controlling toasting or baking, based on the change in shade of the product to be toasted or baked, to be implemented.
Patent ES-2541622-A1 (ES)
Title: Intelligent warning device for earthquakes and fires in buildings
Inventor: GONZALEZ PENUELA GIOVANNI
IPC: G08B21/10
Filed: 2013-11-14
Abstract: Intelligent warning device for earthquakes and fires in buildings which, in the event of an earthquake, provides an early warning, defines evacuation routes and provides building diagnostics. The device consists of two modules: a central processing module (1) and a sensor and transmission module (2). The central processing module (1) consists of three sections: a solar power supply, an acceleration sensor with processing means, and an information processing and data transmission section. The sensor and transmission module (2) consists of two sections: a solar power supply and an acceleration sensor with processing means. The device comprises a network of wirelessly interconnected sensor modules, there being two types of sensor, fire and/or gas sensors and acceleration sensors, the latter being sensitive to seismic movement and listing.
Patent JO-P20180021-A1 (JO)
Title: Anti-phf-tau antibodies and uses thereof
Inventor: THOMAS MALIA
Filed: 2017-03-16
Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
Patent SG-126057-A1 (SG)
Title: System and method for designing component based applications
Inventor: SHENFIELD MICHAEL
Filed: 2006-03-13
Abstract: A system and method for providing a user interface system to develop an application having a first component with descriptors expressed in a structured definition language and a second component expressed as a series of instructions. The individual components interact for processing messages on a runtime environment of a device that are received from a datasource over a network. The component applications comprise data components, presentation components, and message components, which are written in XML code. The component applications further comprise workflow components which are written in a subset of ECMAScript, and are augmented with the XML code. The user interface system comprises a first module, such as a viewer or and editor, for developing the definitions of the first component through interaction with a data model that provides a persistent state of the application. The user interface system comprises a second module for developing the instructions of the second component through interaction with the data model and a backend connector for providing the message mapping information of the data source to the first module. The first module generates the definitions based on the mapping information. The first and second components developed by respective the first and second modules are included in the application with other components where applicable.
Patent TR-201922381-A1 (TR)
Title: Araçlar İçin Bir Yük Sabitleme Mekanizması
Inventor: NECDET ÇAPAR
IPC: B60P7/08
Filed: 2019-12-30
Abstract: Buluş; araçların yükleme alanlarındaki eşya/yükleri sabitlemek üzere, yükleme alanına irtibatlandırılan bir ray (20), bahsedilen ray (20) üzerine konumlandırılan ve yüklerin/eşyaların sabitlenmesine olanak sağlayan en az bir tutucu eleman (30), bahsedilen ray (20) üzerinde oluşturulan, tutucu elemanın (30) istenilen noktada sabitlenmesini sağlamak üzere yapılandırılan en az bir tutunma açıklığı (22), tutucu elemanın (30), çalışma konumunda bahsedilen tutunma açıklığına (22) sabitlenmesini sağlayan hareketli en az bir tutunma kolu (31), tutucu elemanın (30) üzerinde yapılandırılan, dışardan uygulanan kuvvet sonucu tahrik edilerek tutunma kolunun (31) hareket etmesini sağlayan en az bir aktivatör (40) ve tutucu elemanın (30), ray (20) üzerinde kaydırılarak hareket etmesini sağlayan ve yük/eşyaların sabitlenmesini sağlayan sabitleme elemanı (50) içeren bir sabitleme mekanizması (10) ile ilgilidir.
Patent TR-202020854-A1 (TR)
Inventor: TURHAN MUTLU
IPC: D06F39/12
Filed: 2020-12-18
Abstract: Mevcut buluş, bir birinci yan yüzeyi (3), bir ikinci yan yüzeyi (4), bir tabanı (5), bir ön paneli (6), bir arka paneli (7), bir üst kapağı (8), destek sağlamak için yan yüzeyler (3, 4) arasında konumlanan bir koruyucu levhayı (9) içeren bir gövdeye (2) sahip bir ev cihazıyla (1) ilgilidir. Yenilik olarak, koruyucu levha (9), güçlendirilmiş bir sac metaldir.
Patent AR-027369-A1 (AR)
Title: Procedimiento para mejorar el estado de aves de corral jovenes
IPC: A23K50/75
Filed: 2001-02-06
Abstract: Un procedimiento para mejorar el estado de aves de corral, cuyo procedimiento comprende poner a disposicion de las aves de corral para el consumo dentro dedoce días a partir de la incubacion una formulacion alimenticia enriquecida de fracciones de se milla de haba de soja y una formulacion alimenticia adecuadapara la administracion a aves de corral hasta doce días a partir de la incubacion, dicha alimentacion enriquecida en fracciones de semillas de haba de soja.
Patent AR-032235-A1 (AR)
Title: Dispositivo estrujador para elementos de limpieza de instrumentos estregadores mojados o humedos
IPC: A61K47/18
Filed: 2002-01-09
Abstract: Dispositivo estrujador para elementos de limpieza de instrumentos estregadores mojados y humedos, que comprende un alojamiento permeable a los líquidos (1) el cual es fijable por medio de un bastidor de soporte (5) en un recipiente (6) y en el cual se puede estrujar un instrumento estregador por compresion, siendo el instrumento estregador introducido a través de un embudo guiador de introduccion independiente del alojamiento, el cual es fijable en el bastidor de soporte.
Patent AR-033070-A1 (AR)
Title: Dispositivo intravaginal y su metodo de fabricacion
IPC: A61F5/44
Filed: 2002-03-27
Abstract: Un dispositivo intravaginal que tiene una sobrecubierta que contiene un material encerrado, y un cordon de retiro que pasa a través de una porcion de la sobrecubierta formada en lazo, el cordon de retiro que habilita a una usuaria a retirar el dispositivo intravaginal después del uso.
Patent AR-034509-A1 (AR)
Title: Sistema y metodo para el procesamiento de senales de rmn sin acumulacion de pares de fase alternada.
IPC: G01R33/44
Filed: 2002-06-14
Abstract: Un sistema y métodos para mejorar la resolución vertical de los registros de la RMN sobre la base de métodos de adquisición de datos y técnicas de procesamiento de senales que no requieren la aplicación de Acumulación de Pares de Fase Alternada (PAPS). El método se basa en la reducción del nivel de las senales coherentes no provenientes de la formación, al estimar estas senales y eliminar las estimaciones de los trenes de ecos pulsados de la RMN subyacentes, Una vez eliminados los componentes de senales no provenientes de la formación, se aplican métodos estándar de procesamiento de RMN a fin de derivar las propiedades petrofísicas de la formación que se está estudiando. En una realización preferida, el método NOPAPS de la presente invención se practica junto con una secuencia de adquisición de datos, que se puede utilizar para aumentar aún más la velocidad de registro del instrumento o la resolución vertical de las mediciones.
Patent AR-038435-A1 (AR)
Title: Caja plegable
IPC: B65D19/00
Filed: 2003-02-13
Abstract: Una caja plegable incluye un miembro de base que tiene un par de primeros bordes de base y un par de segundos bordes de base que tienen formada en ellos un área de base rebajada. Un par de primeras paredes opuestas unidas en forma pivotable a los primeros bordes de base y que pueden ser orientadas entre una orientación vertical y una orientación plegada en la que se superponen. Un par de segundas paredes opuestas unidas en forma pivotable a los segundos bordes de base y que pueden ser orientadas entre una orientación vertical y una orientación plegada en la que se superponen. Cada una de las segundas paredes opuestas corresponde generalmente en altura y tiene un miembro de proyección dispuesto para ser recibido dentro del área rebajada de los segundos bordes de base cuando están en la orientación plegada superpuesta, y cada pared lateral tiene un área de pared rebajada dispuesta para recibir al miembro de proyección de la segunda pared opuesta plegada sobre ella.
Patent AR-042550-A1 (AR)
Title: Una forma de dosificacion farmaceutica que comprende venlafaxina y memantina
Inventor: VERGEZ JUAN AUGUSTO
IPC: A61K9/24
Filed: 2003-12-19
Abstract: Forma de dosificación farmacéutica que contiene venlafaxina de liberación controlada en el núcleo en combinación con una droga de liberación rápida anti-Alzheimer o anti-Parkinson en el recubrimiento externo. La memantina es utilizada como droga anti-Alzheimer o anti-Parkinson. En dispositivos osmóticos que poseen perfiles de liberación predeterminados. Una realización del dispositivo osmótico incluye un recubrimiento externo que ha sido recubierto por rocío más que por compresión en el dispositivo. El dispositivo es útil para el tratamiento de la depresión en pacientes con Alzheimer y/o Parkinson. El dispositivo también puede ser utilizados para tratar o mejorar otros síntomas asociados con la enfermedad de Alzheimer, la enfermedad de Parkinson o cualquier otro desorden neurológico. Otras formas de dosificación que proveen una liberación controlada, sostenida o extendida de venlafaxina en combinación con una liberación rápida o inmediata de memantina.