baber/WOPTO huggingface dataset:
Patent IL-138703-A0 (IL)
Title: Substituted amides, their production and their use
IPC: A61K31/455
Filed: 1999-04-20
Abstract: An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: A —(CH2)p—R1, where R1 can be pyrrolidine, morpholine, piperidine, —NR5R6 and and R5, R6 and R7 can, independently of one another, be hydrogen, C1-C4-alkyl, CH2Ph, Ph, CH2CH2Ph, it also being possible for the phenyl rings to be substituted by R6, and p can be 1 and 2, and B can be phenyl, pyridyl, pyrimidyl and pyridazyl, it also being possible for the rings to be substituted by up to 2 R8 radicals, and D can be a bond, —(CH2)m—, —CH═CH—, —C═C—, and R2 is chlorine, bromine, fluorine, C1-C6-alkyl, NHCO—C1-C4-alkyl, NHSO2—C1-C4-alkyl, NO2, —O—C1-C4-alkyl and NH2, and R3 is —C1-C6-alkyl, branched or unbranched, and which may also carry a phenyl ring, indolyl ring or cyclohexyl ring which is in turn substituted by a maximum of two R8 radicals, where R8 is hydrogen, C1-C4-alkyl, branched or unbranched, —O—C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COO—C1-C4-alkyl, NHCO—C1-C4-alkyl, —NHSO2—C1-C4-alkyl and —SO2—C1-C4-alkyl; and Y is phenyl, pyridine, pyrimidine and pyrazine and R4 is hydrogen, COOR9 and CO—Z in which Z is NR10R11 and R9 is hydrogen, C1-C6-alkyl, linear or branched, and which may [lacuna] substituted by a phenyl ring which may itself also be substituted by one or two R12 radicals, and R10 is hydrogen, C1-C6-alkyl, linear or branched, and which may [lacuna] substituted by a phenyl ring which itself may also be substituted by one or two R12 radicals, and R11 is hydrogen, C1-C6-alkyl, branched or unbranched, which may also be and substituted by a phenyl ring which may also carry an R9 radical, and R12 can be hydrogen, C1-C4-alkyl, branched or unbranched, —O—C1-C4-alkyl, OH, Cl, F, Br, J, CF3, NO2, NH2, CN, COOH, COO—C1-C4-alkyl, —NHCO—C1-C4-alkyl, —NHCO-phenyl, —NHSO2—C1-C4-alkyl, NHSO2-phenyl, —SO2—C1-C4-alkyl and —SO2-phenyl, R13 is hydrogen, C1-C6-alkyl, linear or branched, and which may [lacuna] substituted by a phenyl ring which may itself also be substituted by one or two R12 radicals, and R14 is hydrogen, C1-C6-alkyl, linear or branched, and which may [lacuna] substituted by a phenyl ring which may itself also be substituted by one or two R12 radicals, and n is a number 0, 1 or 2, and m,q are, independently of one another, a number 0, 1, 2, 3 or 4.
Patent IL-139095-A0 (IL)
Title: Methods for amyloid removal using anti-amyloid antibodies
IPC: A61K39/395
Filed: 1999-05-21
Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
Patent IL-145806-A0 (IL)
Title: Blind fastener with high strength blind head and high clamp and high shear load resistance
IPC: F16B13/12
Filed: 1999-10-05
Abstract: A blind fastener with a pin having a pin shank which extends through a cylindrical main sleeve and expansion sleeve whereby it can be gripped and pulled by an installation tool with the pin having an enlarged pin head at the blind end of the pin shank. The expansion sleeve is located between the pin head and the inner end of the main sleeve and is adapted to move into the inner or blind end of the main sleeve to form a first tulip shaped blind head for clamping workpieces together in response to a relative axial force applied between the sleeves and pin by engagement of the pin head with the expansion sleeve. As the axial force is increased the pin head is moved into the expansion sleeve to form a second tulip head to further clamp the workpieces and to secure the pin, main sleeve and expansion sleeve together at that end and is moved closely adjacent the workpiece surface at the blind side to form a high strength blind head.
Patent IL-158963-A0 (IL)
Title: Dental restorative materials
IPC: A61K6/891
Filed: 2002-05-21
Abstract: The present invention relates to a composition for dental restoration including a dental restorative material and an effective amount of a casein phosphopeptide(CPP)-amorphous calcium phosphate (ACP) complex or casein phosphopeptide(CPP)-amorphous calcium fluoride phosphate (ACFP) complex.
Patent IL-164796-A0 (IL)
Title: Piperazine benzothiazole derivatives, their preparation, pharmaceutical compositions containing themand their use
IPC: C07D417/06
Filed: 2003-04-25
Abstract: The present invention is related to piperazine henzothiazole derivatives, notably for use in the treatment and/or prophylaxis of cerebral ischemic disorders or CNS disorders. The present invention is furthermore related to methods of their preparation.
Patent IL-175584-A0 (IL)
Title: Injectable sustained release deliver devices
IPC: A61K9/00
Filed: 2006-05-11
Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to as "coatings", "skins", or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution undergoes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
Patent IL-188723-A0 (IL)
Title: Substituted triazole derivatives and their use as neurokinin 3 receptor antagonists
Filed: 2008-01-10
Abstract: The present invention relates to compounds of formula (I) wherein R<SUP>1</SUP>, R<SUP>2 </SUP>and R<SUP>3 </SUP>are as defined in the specification and to pharmaceutically suitable acid addition salts thereof. The invention includes all sterioisomeric forms, including individual diastereoisomers and enantiomers of the compound of formula (I) as well as racemic and non-racemic mixtures thereof. It has been found that the present compounds are selective allosteric positive modulators of the human NK-3 receptor for the treatment of anxiety, depression, bipolar disorders, Parkinson's disease, schizophrenia and pain.
Patent RO-125420-A0 (RO)
Title: Electronic device for amplifying and multiplexing the electrical cardiac signals
Inventor: BORZA CLAUDIA
IPC: A61B5/308
Filed: 2009-10-12
Abstract: The invention relates to an electronic device for amplifying and multiplexing the electrical cardiac signals, meant to be used within an ECG apparatus. According to the invention, the device comprises a transitory voltage protection block (1) and represents the input block for the electrical signals gathered from the patient's body, by means of some electrodes, an impedance adapting block (2) comprising some operational amplifiers arranged in repeater configuration, at the output of which there are gathered the electrical signals corresponding to unipolar leads, precordial leads and Wilson's central terminal, an analogous demultiplexer block (3) at the output of which there can be retrieved two electrical signals selected from the input signals, whose difference is amplified in a block (4) consisting of differential amplifiers, also playing the role of rejecting the common-mode noises, the signals obtained thereby being applied by a signal amplifying block (5) to reach an amplitude necessary to some analogous-digital convertors within a microprocessor (microP) which takes over and processes said signals.
Patent RO-125562-A0 (RO)
Title: Heating system with solar panels made of structured cellular polycarbonate plates
Inventor: RUS ADRIAN IOAN
IPC: F24S10/50
Filed: 2010-02-09
Abstract: The invention relates to a heating system with solar panels made of structured cellular polycarbonate plates. According to the invention, the heating system consists of some interior separating walls (2) of the polycarbonate plate channels and alternatively of some orifices (3), which constitute, this way, the channels for the thermal agent circulation, of some ends (4) of the original channels tightly closed with adhesive material and provided with some cold water feeding connections (5) and with some warm water discharge connections (6), thus there being formed a channel for the water continuous circulation, having the shape of a coil which stores and provides warm water at a constant temperature.
Patent RO-127712-A0 (RO)
Title: Beauveria brongniartii strain pathogenic for may bug, melontha melolontha
Inventor: FĂTU ANA CRISTINA
IPC: A01N63/00
Filed: 2011-11-23
Abstract: The present invention relates to a strain belonging to the genus Beauveria brongniartii, deposited in the National Collection of Agricultural and Industrial Microorganisms and which is pathogenic to Melolontha melolontha, insect harmful to plant nurseries and young forest plantations.
Patent RO-132419-A0 (RO)
Title: Process for preparing a composition of blueberry extract with lactoferrin addition
Inventor: OANCEA RODICA SIMONA
IPC: A61K35/20
Filed: 2017-01-04
Abstract: The invention relates to a process for preparing a bioactive ingredient for nutraceutic products. According to the invention, the process consists in admixing a raw anthocyanin extract of wild blueberry with 0.05...0.10% lactoferrin, as powder, to result in a product with antimicrobial and antioxidant properties, having a protein content of 0.1144...0.1284% and a total anthocyanin content of 515...518 mg/l.
Patent AP-2000001924-A0 (AP)
Title: Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines.
Inventor: BOURZAT JEAN-DOMINIQUE
IPC: A61P11/06
Filed: 1999-12-23
Abstract: The invention is directed to physiologically active compounds of formula (i)wherein r1 represents r3-z3, r3-l2-r4-z3-, r3-l3-ar1-l4-z3- or r3-l3-ar1-l2-r4-z3-; r2 represents hydrogen, halogen, lower alkyl or lower alkoxy; a1 represents a straight chain c2-3alkylene linkage optionally substituted by one or more groups chosen from alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, imino, oxo, thioxo, or alkyl substituted by -zr6, -ny1y2, -co2r6 or -c(=o)-ny1y2; l1 represents a direct bond; an alkenylene , alkylene, alkynylene, cycloalkenylene, cycloalkylene, heteroaryldiyl, heterocycloalkylene or arylene or arylene linkage each optinally substituted by (a)an acidic functional group, cyano, oxo, -s(o)mr9, r3, -c(=o)-r3, -c(=o)-or3, -n(r8)-c(=o)-r9, -n(r8)-c(=o)-or9, -n(r8)-so2-r9,-ny4y5 or -[c(=o)-n(r10)-c(r5)(r11)]p-c(o)-ny4y5, or by (b)alkyl substituted by an acidic functional group, or by s(o)mr9,-c(=o)-ny4y5 or -ny4y5; a-[c(=o)-n(r10)-c(r5)(r11)]p-linkage; a-z2-r12-linkage; a -c(=o)-ch2-c(=o)-linkage; a -r12-z2-r12-linkage; a -c(r4)(r13)-[c(=o)-n(r10)-c(r5)(r11)]-linkage; or ab -l5-l6-l7- linkage; z1 is nh17 or o; y is carboxy or an acid bioisostere; and the corresponding n-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates of such compounds and their n-oxides and prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of vcam-1 and fibronection with the integrin vla-4 (a4b1).
Patent IE-910351-A1 (IE)
Title: Propellant gases and their use in pharmaceutical¹preparations
IPC: A61K9/72
Filed: 1991-02-01
Abstract: A propellant gas mixt. (I) consists of two or more components which contain at least one lower partially fluorinated alkane and opt. one or more cpds. chosen from TG11, TG12, TG114, lower alkanes and DMF. The partially fluorinated lower alkane is pref. 1,1-difluoroethane, 1,1,1,2-tetrafluoroethane, penta-fluoroethane, 1,1,1,2,3,3,3-heptafluoropropane (TG227) and the lower alkane is pref. propane, butane or pentane. (I) pref. also contains a surfactant which is pref. a phospholipid, a sorbitan ester with a higher opt. satd. fatty acid or a polyethoxy-sorbitan ester of a higher, pref. unsatd. fatty acid. The surfactant is esp. a lecithin, a polyoxyethylene sorbitanoleate or sorbitantrioleate.
Patent IE-910708-A1 (IE)
Title: Parasiticidal composition and method for its making and use
Inventor: GLADNEY JULIE G
IPC: A01N53/00
Filed: 1991-03-04
Abstract: A liquid phase composition of a pyrethroid in concentrations greater than 50% w/w that may be used as a basis for other pyrethroid containing formulations in physical phases other than the liquid phase is described. A method of treatment utilizing the composition on domestic mammal is also described. The composition can be applied as a small dose to a localized region of the animal's body which is then delivered to relatively all of the animal's body surface by migration of the pyrethroid.
Patent MA-22109-A1 (MA)
Inventor: R S PESIRI
IPC: B26B21/56
Filed: 1991-04-02
Abstract: A shaving system of the wet shave type includes a support member that has a skin engaging surface in which a plurality of spaced apertures are defined. A blade unit has a generally tubular upstanding body portion of predetermined height that defines a central aperture, an integral, inwardly facing flange at one end that has a continuous sharpened shaving edge, and integral outwardly extending flange structure adjacent the opposite end of the tubular body. Depending latch structure is formed integrally with the support member and aligned with each aperture, and integral support structure disposed between the latch structure and the skin engaging surface receives and guides the body portions of the blade units with the latch structure engaging the outwardly extending flange structures of the blade units to secure the blade units in the support member.
Patent MA-22340-A1 (MA)
Inventor: L A GILBERT
IPC: A61Q1/02
Filed: 1991-11-15
Abstract: A mild skin cleansing composition in the form of a bar comprising from about 0.5% to about 20% of a mixture of a silicone gum and a silicone fluid wherein the gum:fluid ratio is from about 10:1 to about 1:10, preferably from about 4:1 to about 1:4, most preferably from about 3:2 to about 2:3. The silicone component is a skin mildness/moisturizing aid which imparts superior, durable conditioning to skin washed with the composition. Processes for preparing a mild skin cleansing toilet bar with this silicone component are disclosed.
Patent MA-27385-A1 (MA)
Title: Therapie combinee de maladies hyperproliferatives.
Inventor: BEEBE JEAN SACCUZZO
IPC: A61K31/4745
Filed: 2005-02-18
Abstract: DEPOSANT Société   dite   :   PFIZER PRODUCTS   INC. REVENDICATION DE   PRIORITES US 19  Août   2002 60/404,461 Thérapie combinée de maladies hyperprolifératives La présente invention concerne une méthode pour le traitement de maladies hyperprolifératives. Plus particulièrement, la présente invention concerne une méthode pour le traitement de maladies hyperprolifératives, telles que le cancer, comprenant l'étape consistant à administrer à un mammifère, nécessitant un tel traitement, simultanément ou séquentiellement, (i) une quantité thérapeutiquement efficace d'un dérivé de taxane, d'un complexe de coordination de platine choisi dans le groupe consistant en carboplatine, tétraplatine et topotécan, d'un analogue de nucléoside choisi dans le groupe consistant en chlorhydrate de gemcitabine et 5-FU, d'une anthracycline, d'un inhibiteur de topoisomérase choisi dans le groupe consistant en l'étoposide, le téniposide, l'amsacrine, le topotécan et le Camptosar??, un inhibiteur d'aromatase ; et (ii) une quantité thérapeutiquement efficace d'un dérivé d'isothiazole. Les associations de la présente invention peuvent comprendre éventuellement un agent antihypertensif. La présente invention concerne également des compositions pharmaceutiques utiles dans le traitement de maladies hyperprolifératives chez un mammifère, contenant ces associations. La présente invention concerne également des kits comprenant un premier compartiment avec un composé de formule 1 et un deuxième compartiment contenant un dérivé de taxane, un complexe de coordination de platine, un analogue de nucléoside, une anthracycline, un inhibiteur de topoisomérase ou un inhibiteur d'aromatase, et un troisième compartiment contenant un agent antihypertensif.
Patent MA-38929-A1 (MA)
Title: Mélange de sels en tant que substance d'accumulation pour une centrale héliothermique fonctionnant à l'huile
Inventor: EGUIGUREN SANTIAGO
IPC: C09K5/12
Filed: 2016-03-25
Abstract: Mélange de sels en tant que substance d'accumulation d'énergie d'un échangeur de chaleur de centrale héliothermique, par exemple la nuit ou par temps couvert. Le mélange de sels selon la présente invention remplace les composés classiques nitrate de potassium et nitrate de calcium dans les mélanges de sels par un sel double potassium-calcium avec un rapport du potassium au calcium de 1/5.
Patent UY-27119-A1 (UY)
Title: Composiciones farmacéuticas que contienen un inhibidor de cox-ii y un relajante muscular
Inventor: FAOUR JOAQUINA
Filed: 2002-01-09
Abstract: La presente invención provee una composición farmacéutica y una forma de dosificación que contienen en combinación un inhibidor de COX - II y un relajante muscular. La composición farmacéutica es útil para el tratamiento de dolor y desórdenes y síntomas relacionados con dolor. La combinación provee una respuesta terapeútica mejorada cuando se compara con cualquiera de las drogas solas. La composición farmacéutica puede ser incluída en cualquier forma de dosificación.
Patent UY-28431-A1 (UY)
Title: Peliculas que se disuelven por via oral
Inventor: CHAN SHING YUE
IPC: A61K/
Filed: 2004-07-22
Abstract: Se describen en este documento preparacione orales de película que se disuelven rápidamente para la liberación rápida de un agente activo en la cavidad bucal, en particular, películas orales que se disuelven rápidamente que comprenden un agente activo de nicotina que logra una buena absorción transbucal y que proporciona alivio del ansía de nicotina a un individuo.
Patent UY-28817-A1 (UY)
Title: Compuestos de imidazol para el tratamiento de trastornos neurodegerativos
Inventor: BRODNEY MICHAEL AARON
IPC: C07D403/06
Filed: 2005-03-22
Abstract: La presente invención se refiere a los compuestos de fórmula I en la que R1, R2, R3, R4, R6, R7, y A son como se han definido. Los compuestos de la fórmula I tienen actividad en la inhibición de la producción de ABeta-péptidos. La invención también se refiere a las composiciones y procedimientos farmacéuticos para tratar enfermedades y trastornos, por ejemplo, trastornos neurodegenerativos y/o neurológicos, por ejemplo enfermedad de Alzheimer, en un mamífero que comprende los compuestos de la fórmula I.
Patent UY-30250-A1 (UY)
Title: Composiciones de pintura mejoradas
Inventor: WILLIAMS NEAL ST JOHN
IPC: C09D5/04
Filed: 2007-03-30
Abstract: Una composicion de pintura acuosa que comprede i) un polímero aglutinante ii) una sal de un ácido graso con una longitud de cadena lineal de entre 10 y 26 átomos de carbono donde a dicha composicion se le puede dar la forma de un cuerpo de pintura autoportante, dimensionalmente estable.
Patent ES-179673-A1 (ES)
Title: MEJORAS INTRODUCIDAS EN LA PREPARACIoN DE CAPAS FOTOSENSIBLES
Filed: 1947-09-10
Abstract: Mejoras en la preparación de capas sensibles a la luz, caracterizadas porque se dispone en la capa sensible a la luz una combinación diazo derivada de una p-diamina o un o-amino-naftol, un componente de acoplamiento de bajo potencial de acoplamiento con respecto a la combinación diazo, y por lo menos otra combinación diazo de potencial de acoplamiento rápido con respecto a dicho componente de acoplamiento, o por lo menos otro componente de acoplamiento de potencial de acoplamiento rápido con respecto a la combinación diazo.
Patent ES-191638-A1 (ES)
Title: Un distribuidor doble para frenos de aire comprimido
Filed: 1950-02-07
Abstract: Distribuidor doble para frenos de aire comprimido para vehículos con remolque que comprende dos distribuidores independientes que alimentan por separado dos secciones del circuito de los frenos y están accionados por la palanca a pedal del freno caracterizado porque dichos distribuidores están reunidos en un solo cuerpo y están accionados por una sola palanca de balancín cuyo punto de articulación al tirante accionado por el pedal del freno es desplazable de manera que pueda variar la longitud de los brazos de dicho balancín durante su funcionamiento.
Patent ES-193400-A1 (ES)
Title: Perfeccionamientos introducidos en los compresores de aire
Filed: 1950-05-31
Abstract: Perfeccionamientos introducidos en los compresores de aire caracterizados porque conforme a los mismos la admisión del aire en el compresor se efectúa por el propio pistón que acciona una membrana dispuesta en la culada del compresor.
Patent ES-196622-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA FABRICACIoN DE ARTiCULOS MOLDEADOS DE RESINAS SINTÉTICAS
Filed: 1951-02-15
Abstract: Procedimiento para la fabricación de artículos moldeados de resinas sintéticas caracterizado porque partiendo de la mezcla de resinas formol-urea y alkydicas se las somete a un baño de impregnaicón constituído por un plastificante líquido de alto peso molecular se extrae el exceso de plastificiante por cualquier método normal se trabaja la mezcla en un cilindro o en un mezclador Banbury para darle uniformidad y se agregan regenerados de caucho caragas colorantes materias vulcanizantes y otros productos químicos según las cualidades que se deséen obtener introduciendo después la masa en moldes apropiados para someterla a la influencia del factor tiempo en condiciones especiales de temperatura y presión en prensas.
Patent ES-197547-A1 (ES)
Title: UN APARATO NáUTICO DE FLOTADORES
Filed: 1951-04-23
Abstract: Un aparato náutico que tiene dos flotadores ahusados reunidos por travesaño que sostienen una barquilla en que se alojan al pasajero o pasajeros caracterizado por los puntos siguientes juntos o separados: a) La propulsión se asegura por dos ruedas de paleta dispuestas en volada simétricamente con relación al eje longitudinal de los flotadores y un poco delante del centro del aparato. b) Dos pedales independientes atacan cada uno directamente una de las ruedas de paletas siendo necesarios sólo tres cojinetes para el funcionamiento del aparato. c) La dirección del aparato se asegura únicamente por medio de ruedas de paletas que con este fin se hacen mover a velocidades y en las direcciones convenientes
Patent ES-197743-A1 (ES)
Title: Un perfeccionamiento en los faros para automoviles y vehiculos analogos
Filed: 1951-05-07
Abstract: Perfeccionamiento en los faros para automóviles y vehículos análogos que esencialmente consiste en introducir los filamentos en la lámpara-faro por medio de un porta-filamentos de la medida normal de un portalámparas con medios para su maniobra y sujeción con junta hermética a la parte posterior del faro o lámpara-faro que hace las veces de reflector y que será de cristal material sintético metálico o cualquier otro apropiado a dicha finalidad.