baber/WOPTO huggingface dataset:
Patent CA-2090650-C (CA)
Title: Method of producing tissue factor pathway inhibitor
Inventor: DIAZ-COLLIER JUDITH A
IPC: A61P7/02
Filed: 1993-03-01
Granted: 2008-01-29
Abstract: A method is disclosed for the production of tissue factor pathway inhibitor (TFPI) which comprises expression of a non-glycosylated form of TFPI in E. coli as host and obtaining a highly active TFPI by in vitro refolding of the protein in which inclusion bodies isolated from the E. coli cells are subjected to stepwise purification comprising either series (A) or series (B) as follows: (A) (1) subjecting the inclusion bodies to sulfitolysis to form TFPI-S-sulfonate, (2) purifying TFPI-S-sulfonate by anion exchange chromatography, (3) refolding TFPI-S-sulfonate by disulfide interchange reaction, and (4) purifying active refolded TFPI by cation exchange chromatography, or (B) (1) subjecting the inclusion bodies to reduction with .beta.-mercaptoethanol in urea to form reduced TFPI, (2) purifying the reduced TFPI by cation exchange chromatography, (3) refolding reduced TFPI by disulfide interchange reaction in urea, and (4) purifying the active refolded TFPI by cation exchange chromatography.
Patent CA-2092866-C (CA)
Inventor: CONNELLY MARK CARLE
IPC: G01N33/554
Filed: 1993-03-29
Granted: 2007-06-26
Abstract: The present invention provides a novel cellular fixative composition and method of cellular fixing and cellular analysis wherein cells may be fixed for further analysis without destroying the cell's surface markers, cellular morphology, and the cell's light scattering properties. Treatment of cells with the fixative as described herein also allows antibodies or other desired components to enter the cell through the cellular membrane, without allowing important contents of the cell to escape. As an added benefit, the fixative composition of the invention may also kill or at least inactivate or reduce the activity of deadly virus contained in the cell. In its broadest aspect, the presently claimed fixative composition comprises at least three components, and in more preferred embodiments, four components. In a particularly preferred embodiment, the fixative composition described herein comprises at least one compound suitable for increasing the permeability of a cellular membrane, at least one compound that facilitates transportation of components across cellular membranes, at least one detergent, and at least one compound having the structure: R1R2R3R4R5 - Ar - X
Patent CA-2098686-C (CA)
Inventor: WITHERSPOON ROMEO R
IPC: H01M4/62
Filed: 1993-06-17
Granted: 1999-12-28
Abstract: In a preferred method, an electrode for a lead-acid battery is prepared in a new continuous process without the conventional curing step. The general procedure for preparing electrodes includes preparing a mixture (paste) comprising an active material precursor and an inhibitor. The active material precursor includes lead oxides having at least 10% by weight lead oxide in the form of Pb3O4 (red lead), and a BET surface area of at least about 0.8 m2/gram; desirably about 1.00 to 1.50 m2/gram and preferably about 1.0 to 1.25 m2/gram. The inhibitor prevents formation of tribasic lead sulfate and tetrabasic lead sulfate from the precursor material, except at elevated temperature. The paste is applied to electrode grids and reacted at elevated temperatures for between about 5 and about 30 minutes, to form the active material of the electrode for both positive and negative electrodes. Plates are then assembled into batteries and charged. Negative electrodes differ from the positive, mainly in the additives used.
Patent CA-2122724-C (CA)
Title: Proteines de fusion contenant du mgf et du il-3
Inventor: WILLIAMS DOUGLAS E
IPC: C07K19/00
Filed: 1992-11-19
Granted: 1999-05-11
Abstract: Protéine de fusion comprenant MGF et IL-3. Ces protéines de fusion présentent une activité biologique améliorée.
Patent CA-2123605-C (CA)
Title: Method and apparatus for communication control in a radiotelephone system
Inventor: RAITH ALEX KRISTER
IPC: H04W48/20
Filed: 1993-09-16
Granted: 2003-11-25
Abstract: In a radiotelephone system, the control channel of each cell can be configured to broadcast absolute information about its cell and relative information about other cells including the characteristic of the cell. Further, the location of other control channels may also be included among the information broadcast over a control channel of a particular cell. This information is then used to lock a mobile unit to a preferred cell.
Patent CA-2123666-C (CA)
Title: Anatomical restoration dental implant system with interlockable various shaped healing cap assembly and matching abutment member
Inventor: DAFTARY FEREIDOUN
IPC: A61C8/00
Filed: 1994-05-16
Granted: 1999-10-26
Abstract: The present invention is an anatomical restoration dental implant system with an interlockable various shaped healing cap assembly and a matching abutment member. The healing cap assembly includes an integral bolt member which has a widened head segment and an elongated shaft segment. The healing cap assembly also includes a healing cap member which has a divergent body with a larger rounded triangle shaped end. The healing cap member also has a stepped interior bore with threaded section offset from that of the bolt member so that the healing cap member and the bolt member are interlockable.      The present invention also comprises a matching abutment member for supporting a tooth analogue with a rounded triangle shaped root. The abutment member has a bolt segment which is identical to the bolt member of the healing cap assembly, and a frusto-conical shaped head segment. The large end of the frusto-conical shaped head segment of the abutment member is circular shaped and smaller than the rounded triangle shaped end of the healing cap member, such that when the abutment member is attached to the healing cap member, a rounded triangle shaped shoulder is created for matching perfectly with the rounded triangle shaped root of the tooth analogue.
Patent CA-2125330-C (CA)
Inventor: COLAROW LADISLAS
IPC: A23L29/10
Filed: 1994-06-07
Granted: 2004-11-30
Abstract: The present invention is directed to heat-stabilizing compositions for proteins and protein-containing emulsions containing lysolecithin and a polymer of glucides selected from pectin, xanthan, alginate, carragenate, gum Arabic and tragacanth and mixtures thereof. It is also directed to foodstuffs containing such compositions.
Patent CA-2129130-C (CA)
Inventor: MICHAEL DANIEL W
IPC: C11D3/43
Filed: 1993-02-08
Granted: 1998-08-25
Abstract: Hard surface detergent compositions comprise nonionic detergent surfactant; trip opylene glycol or short chain alkyl ether of tripropylene glycol as a hydrophobic cleaning solvent; and optional, but pref erred suds control system comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions ar e preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present. The compositi ons clean vinyl no-wax flooring without rinsing and without substantial filming/streaking.
Patent CA-2132995-C (CA)
Title: Hydrocracking of feedstocks and catalyst therefor
Inventor: PRADA RICARDO
IPC: B01J23/89
Filed: 1994-09-27
Granted: 2004-05-11
Abstract: A tri-elemental catalyst on a support that includes a pentasil crystalline zeolite and is suitable for hydrocracking and hydrogenation of aromatics-containing petroleum hydrocarbon feedstocks such as hydrotreated cracked feedstock, virgin feedstock, vacuum distillate, middle distillate, mixtures thereof, and the like, is disclosed. The catalyst is suitable for hydrodesulfurization as well as hydrodenitrogenation, thus the feedstock can contain sulfur and nitrogen in addition to the aromatic components. Hydrocracking and aromatics hydrogenation of the petroleum hydrocarbon feedstocks is accomplished under a relatively wide range of process conditions in plural process zones using the tri-elemental catalyst that contains a catalytically active metal phase constituted by a Group VI-B element, a Group VIII first transition series element and a Group VIII second transition series element. In an upstream zone the catalytically active metal phase is supported on a titania-alumina support containing about 5% to about 30% by weight titania in the support. In a downstream zone the catalytically active metal phase is supported on a titania-alumina-pentasil crystalline zeolite support. The preferred pentasil crystalline zeolite is ZSM-5.
Patent CA-2140720-C (CA)
Title: Transport system with electric movers
Inventor: SAKAGAMI TATSUYA
IPC: G05D1/02
Filed: 1995-01-20
Granted: 1998-11-24
Abstract: A transport  system   has a preceding and some succeeding electric movers (1) each having a built-in single brake-less drive motor (8) which rotates a drive wheel such that, when power supply to the motor is intercepted, and each mover can freely be displaced and halted surely at a desired station.    The succeeding movers automatically assume a storage state, when the preceding mover is halted, and each mover has a photoelectric switch (23) that, when in its sensing state, intercepts the power supply.    Each mover further has a first detectable member (26) to be sensed by the switch (23) of the succeeding mover so as to halt it, when it has approached preceding one beyond a limit.     The transport system further has a stopping mechanism (28) composed of a stopper (29) and a second detectable member (30), which are rockable sideways with respect to the mover.     The second detectable member (30) is of such a length along the travel path of the movers, that the switch (23) senses this member (30) in its operative position, before the contact member (25) abuts against the stopper (29).
Patent CA-2142652-C (CA)
Title: Security device
Inventor: WINNER KEVIN D
IPC: E05B17/00
Filed: 1995-02-16
Granted: 1999-01-19
Abstract: A security device useful in preventing the theft of bicycles, mopeds and the like comprises a generally U-shaped shackle member having two parallel arms connected to one another by an intermediate bight.  A second member, either U-shaped or a bar extends between and engages both of said arms and is moveable axially therealong toward or away from the bight.  Locking means coact with said second member and at least one of said arms to fix the position of the second member with respect to the arms.  The use of longitudinally spaced semicircular grooves on one or both arms cooperating with a spring biased spherical bearing means associated with the second member permits it to be freely positioned along the shackle member. A lock mechanism is used to engage one of said grooves  to lock  the  bar  in  position.    Alternatively, positioning of the second member may be achieved by the use of a pawl and ratchet arrangement which allows the second member to be freely movable in either direction along the arms when the device is unlocked, but only in the direction toward the bight when the device is locked.  The locking member may be a combination lock or may be activated by a key or remote transmitter.   When the device includes grooves or ratchet teeth along both arms,  a singular lock may be used to simultaneously or sequentially co-act with the two arms. Alteratively, two separate locks may be utilized.  The device may also include a compressible and extendible rubber or elastomeric boot preferably in the form of bellows.  This boot provides a protective cover around ratchet teeth or semi-circular grooves that are longitudinally spaced along one of the arms of the U-shaped member.   The boot progressively surrounds  the  ratchet  teeth  or  grooves  as  the  rod  is disengaged or withdrawn from the sleeve.  Additional means comprising plastisol coatings and bubble wrap material may be included to protect the various elements of the device and the bike from damage and wear.
Patent CA-2143666-C (CA)
Title: Dispositif de communications assistee par ordinateur
Inventor: FREADMAN TOMMYCA
IPC: H04M1/725
Filed: 1994-06-30
Granted: 2004-02-24
Abstract: Un dispositif informatique périphérique (10) sert de combiné téléphonique dans un mode de fonctionnement téléphonique et de centre de commande audio dans un mode de fonctionnement à commande vocale.
Patent CA-2145015-C (CA)
Title: Hybrid condensation-absorption olefin recovery
Inventor: PHILLIPS CHRISTOPHER LEE
IPC: C07C11/04
Filed: 1995-03-20
Granted: 2007-04-10
Abstract: A hybrid condensation-absorption process and unit is disclosed for the recovery of olefins. A mixed-component stream containing hydrogen, methane and olefins is compressed and refrigerated against propylene refrigerant to partially condense the stream. The condensate is stripped of volatile components and fed to a fractionation unit such as a deethanizer. The volatile components stripped from the condensate and the non-condensed vapor from the mixed-component stream are fed to a solvent absorption unit to remove olefins which are absorbed in the solvent. The olefins-rich solvent is regenerated to recover olefins and lean solvent. The lean solvent is recirculated to the absorption unit. The olefins recovered from regeneration of the solvent are fed to the fractionation unit along with the pre-stripped condensate.      Vapor from the absorption unit is cryogenically processed to recover a crude hydrogen product, a fuel gas product and residual olefins which can be recycled to the absorption unit. The hybrid process eliminates the need for low temperature (ethylene) refrigeration equipment, generally required by conventional condensation-based olefins recovery technology, and substantially reduces the solvent recirculation rate to the absorption unit and eliminates hydrogen expansion as compared to conventional absorption-based technology.
Patent CA-2148346-C (CA)
Title: Apparatus for gripping a down hole tubular
Inventor: DURRETT CLYDE DOYLE
IPC: E21B19/07
Filed: 1993-11-12
Granted: 1997-10-21
Abstract: An apparatus for gripping a down hole tubular for support and rotation, or a string of such tubulars, includes a body element (10) adapted to be rotated at high torques either by a top head drive or a rotary table of an earthdrilling machine. Gripping elements (28) are mounted in a central cavity of the body element (10), and each gripping element (28) includes a lower gripping portion (30) shaped to engage a tapered shoulder of a length of drill pipe to support the drill pipe and an upper gripping portion (50) shaped to engage the tool joint of the drill pipe to rotate the drill pipe.
Patent CA-2149728-C (CA)
Inventor: EMERY ROY WILLIAM
IPC: D21J5/00
Filed: 1995-05-18
Granted: 1998-06-30
Abstract: A cam actuated system for precisely timing and quickly operating a locking and unlocking mechanism for a quick change press, said locking and unlocking system being comprised of at least four locking levers, with at least two of said levers located at  each  side of  said press,  and said cam actuated mechanism being comprised of a series of at least two cam rollers which roll along the first series of at least two cam tracks for locking said press, and along a second series of at least two cam tracks, each of said series of cam tracks being fixedly mounted at a predetermined location in the travel path of said press.
Patent CA-2151636-C (CA)
Inventor: YOO MUN-SU
IPC: B62M11/14
Filed: 1995-06-13
Granted: 2000-03-28
Abstract: A forward-drive apparatus for a bicycle comprises a drive transferring portion including a pedal fixed to a pedal shaft of a bicycle and for transferring the drive force to a drive sprocket connected by means of a chain to a rear wheel; a drive switching portion for enabling the drive force generated from the drive transferring portion to rotate the rear wheel in a forward or idle state; and a drive coupling portion for enabling the forward or idle rotation of the drive sprocket according to the operation of the drive switching portion, and for working the bicycle in a forward or idle rotation according to the selection of a lever during the back-pedaling of the bicycle, thereby relieving user's fatigue, preventing the loss of the physical energy and enabling the well-muscled movement of legs in every-day life.
Patent CA-2152401-C (CA)
Inventor: GARRET CLAUDE
IPC: A61P43/00
Filed: 1994-01-18
Granted: 2008-08-26
Abstract: Synergising associations characterized in that they are comprised of at least one product having an antagonist activity on NK1 receptors and at least one product having an antagonist activity on NK2 receptors. Said associations are useful in the treatment of diseases involving the substance P and/or neurokinine A.
Patent CA-2153048-C (CA)
Title: Process for producing nanoscale ceramic powders
Inventor: HELBLE JOSEPH J
IPC: C01G25/00
Filed: 1994-01-19
Granted: 1999-02-02
Abstract: Submicron sized ceramic particles are produced by combining a ceramic precursor with an organic or carbonaceous carrier material, and exposing droplets of the mixture to a temperature sufficient to cause of the organic material and subsequent vaporization and nucleation, or diffusion and oxidation, of the ceramic precursor to form pure, crystalline, uniform nanophase ceramic particles.
Patent CA-2158139-C (CA)
Inventor: MARTIN GEOFFREY S
IPC: A61M5/158
Filed: 1994-03-16
Granted: 2002-05-14
Abstract: The invention provides a dual lumen catheter (20) comprising outer and inner tube materials (28, 30). A main portion (22) extends axially and has a selected first cross section and includes main portions of the respective outer and inner tube materials which together define an annular intake lumen (32) and a main part of a return lumen (34) contained inside the intake lumen. A transition portion (67) is made up integrally of both the outer and inner tube materials and has a second cross section smaller than the first cross section. The transition portion extends axially from the distal end of the main portion and this can be extended to include a tip portion (65) made up only of outer tube material and which extends axially from the transition portion. The transition portion on its own, or with the tip portion, defines a tip section (26) which is a continuation of said main part of the return lumen to complete the return lumen. A method of manufacturing the catheter is also disclosed.
Patent CA-2159163-C (CA)
Title: Compositions thermoplastiques ignifugees a base de polyamide et leur application au revetement de cables electriques
Inventor: BREANT PATRICE
IPC: C08K5/00
Filed: 1995-09-26
Granted: 2001-12-04
Abstract: La présente invention concerne des compositions thermoplastiques souples à base d'une matrice polyamide, d'une phase dispersée polyéthylénique et d'a gents ignifugeants répartis entre les deux phases. Ces compositions présentent de bonnes propriétés mécaniques, une tenue au feu et aux solvants améliorée et éventuellement une excellente tenue dimensionnelle à chaud. Elles peuvent êt re utilisées comme revêtements de câbles électriques, comme tubes ou dans la conception d'objets obtenus par moulage, formage ou filmage.
Patent CA-2162586-C (CA)
Title: Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
Inventor: GRAINGER DAVID J
IPC: A61K31/138
Filed: 1994-05-12
Granted: 2006-01-03
Abstract: TGF-beta activators and TGF-beta production stimulators are employed to maintain or increase vessel lumen diameter in a diseased or injured vessel of a mammal. Conditions such as restenosis following angioplasty, vascular bypass grafts, transplanted organs, atherosclerosis or hypertension are characterized by a reduced vessel lumen diameter. In a preferred embodiment of the invention, TGF-beta activators and production stimulators inhibit abnormal proliferation of smooth muscle cells. TGF-beta activators or production stimulators that are not characterized by an undesirable systemic toxicity profile at a prophylactic dose are also amenable to chronic use for prophylactic purposes with respell to disease states involving proliferation and/or migration of vascular smooth muscle cells over time. Further provided is a method for determining TGF-beta in vitro, thereby identifying a patient at risk for atherosclerosis and monitoring a recipient that has received one or more administrations of a TGF-beta activator or production stimulator.
Patent CA-2166663-C (CA)
Title: Circuit breaker having two chambers pep pole
Inventor: PERRET MICHEL
IPC: H01H33/14
Filed: 1996-01-05
Granted: 1999-11-30
Abstract: The circuit breaker has two identical chambers of each pole, each having a ceramic enclosure (10,10') containing mobile and semi-mobile main contacts (12,17). The mobile main contact (12) is integral with a moving arc contact, a blowout cylinder (14) and a nozzle (15). A semi-mobile arc contact (18) is guided within a metallic cylinder (20). The mobile assembly is driven by a push-rod connected by levers (31) to an actuating rod (32) operated by a control at the foot of the insulating column (3). It is coupled to the semi-mobile assembly by insulating rods (e.g. 41A,42A;51A,52A) jointed (43,53) in the central casing (4). These ensure that the semi-mobile assemblies move at the same speed as the mobile ones and in the opposite direction.
Patent CA-2168719-C (CA)
Inventor: WHITEHOUSE RONALD L S
IPC: A61C17/06
Filed: 1996-02-02
Granted: 2000-06-20
Abstract: An oral suction tip is described which includes a tubular body. The tubular body has a peripheral sidewall, a first end, a second end, and a single passage for transmitting fluids extending between the first  end and the second end.   A mouthpiece is provided at the second end of the tubular body. At least one vacuum release aperture extends through the sidewall of the tubular body in direct communication with the fluid passage.  The at least one vacuum release aperture is spaced from the mouthpiece, such that when the mouthpiece is inserted into a patient's mouth the at least one vacuum release aperture is not confined within the patient's mouth.  A porous guard overlies in spaced relation the at least one vacuum release aperture.  This prevents accidental blockage of the at least one vacuum release aperture and also prevents regulation of the suction by means of the at least one vacuum release aperture.
Patent CA-2170463-C (CA)
Inventor: TAKEI NORIYUKI
IPC: B60N2/75
Filed: 1996-02-27
Granted: 2000-08-01
Abstract: A  method  is  described  for  forming  an  armrest comprising a three-dimensional box-like trim cover assembly having slit and holes formed therein, a frame, and a shaft separate from the frame.  The frame is inserted through the slit into the inside of the trim cover assembly, and then, the shaft is inserted through one hole into the trim cover assembly.   The shaft is connected to the  frame at a predetermined position within the trim cover assembly via a connecting element.  Thereafter, this incomplete armrest unit is subject to foaming in a foaming die, to thereby form a complete armrest.  The trim cover assembly includes a high-density foam layer and an impregnation preventing film having ventilation holes formed therein in order to prevent impregnation of liquid foaming material into a foam wadding layer of the trim cover assembly and attained air permeability of the armrest.
Patent CA-2173324-C (CA)
Inventor: DO COUTO FERNANDO J R
IPC: A61K51/10
Filed: 1993-11-16
Granted: 2008-07-22
Abstract: An anti-KC-4 humanized monoclonal antibody that comprises the variable regio ns of the light and heavy chains of the anti-KC-4 murine antibody, wherein the light chain has 7 amino acids and the heavy cha in has 12 amino acids of the framework regions substitut ed with amino acid present in equivalent positions in antibodies of a species o ther than murine, and the constant regions of a human an tibody. The antibody may be labeled and/or glycosylated, and is presented as a compo sition with a carrier. The anti-KC-4 monoclonal antibody is used in diagnostic kits for cancer and in in vivo methods of imaging and tre ating a primary or metastisized cancer, and in vitro dia gnosis and ex vivo purging neoplastic cells from a biological fluid. RNAs and DNAs encode the monoclonal antibody, and a hydrid vector carr ying the nucleotides and transfected cells express the peptides.