baber/WOPTO huggingface dataset:
Patent CN-201378192-Y (CN)
Inventor: CHANGHUI CHEN
IPC: G09B23/18
Filed: 2008-12-08
Granted: 2010-01-06
Abstract: 本实用新型综合布线工程工具箱属于测试装置领域，综合布线工程工具箱是由箱体和箱盖组成，在箱体内设置有工具的保护棉，在工具的保护棉上设置有工具摆放的位置凹槽，在箱盖面板上设置有交叉线测试显示灯和直通线测试显示灯，在箱盖上设置有交叉线测试接口，在箱盖上设置有直通线测试接口，交叉线测试和直通线测试线路板安装在箱盖上，测试直通线和交叉线主机端的电路由多谐振荡器时钟产生电路、LED灯移位闪亮控制电路和LED指示电路组成，LED灯移位闪亮控制电路主要由IC1主控计数器和时钟产生电路的时钟连接，多谐振荡电路时钟输出接主控计数器，作为电路的计时时钟，用于循环测试每线的连接情况。主控计数器IC1的计数输出引脚按引脚顺序分别连接各LED灯。LED显示电路由三极管，发光二极管，连接插座被测网线组成。本实用新型高效组合了多种布线工具，改进了交叉线的测试，方便施工人员和初学者使用。
Patent CN-201346695-Y (CN)
Title: 卧式加工中心
Inventor: SHANZHANG LI
IPC: B23Q11/10
Filed: 2008-12-16
Granted: 2009-11-18
Abstract: 本实用新型属于机械(先进制造技术与装备)类领域，具体涉及一种数控卧式加工中心。本实用新型的技术方案包括：基础部件、主轴系统、液压系统、电气系统、冷却系统、自动换刀机械系统；其特征在于：主轴设有液压浮动打刀机构；主轴系统设有主轴气幕保护机构；主轴端盖设有圆周均匀分布的6个切削液喷嘴结构；冷却系统采用3个高压大流量水泵供应冷却液，分别形成三个供应冷却液支路；液压系统的供油回路中设有电磁溢流阀控制回路；本实用新型还设有油水自动分离结构。具有冷却迅速全面，精度稳定性高，主轴轴承寿命长，环保节能等优点。
Patent CN-201334467-Y (CN)
Title: 煤气系统填料洗涤塔
Inventor: CHENG LU
IPC: C10K1/08
Filed: 2008-12-11
Granted: 2009-10-28
Abstract: 本实用新型涉及一种煤气系统填料洗涤塔，洗涤塔上部的侧壁上设有迷宫式捕雾器，迷宫式捕雾器下方的洗涤塔内安装有槽盘式液体分布器，槽盘式液体分布器下方安装有槽盘式液体再分布器，槽盘式液体分布器与槽盘式液体再分布器之间填充填料。该洗涤塔不仅克服了雾沫夹带的问题，而且能够有效降低洗涤塔的设备高度，减少设备投资。
Patent CN-201371574-Y (CN)
Inventor: HUIQING LU
IPC: B29C65/00
Filed: 2008-12-30
Granted: 2009-12-30
Abstract: 本实用新型提供了一种带深度感应的塑胶焊接机，包括用于检测焊接深度的深度测量元件和与深度测量元件电连接的焊接控制中心。本实用新型所述带深度感应的塑胶焊接机，通过在焊接机上设置与焊接控制中心电连接的深度测量元件，使得焊接深度能够被检测，确保焊接深度的精确控制，同时，深度感应信号被反馈到焊接控制中心后，由焊接控制中心控制相应的焊接执行器件，以控制焊接压力，保证焊接效果。
Patent CN-201334704-Y (CN)
Title: 深入式下水道过滤丝
Inventor: ZHANPENG ZHANG
IPC: E03C1/26
Filed: 2009-01-05
Granted: 2009-10-28
Abstract: 一种深入式下水道过滤丝，涉及一种防止下水道堵塞的部件。本实用新型的深入式下水道过滤丝是由卡座和过滤丝构成的，卡座为环型，过滤丝为锥型螺旋状，过滤丝装在卡座的下端。本深入式下水道过滤丝使用时，只需插入下水道就可以用了。本深入式下水道过滤丝采用的是沿伸式，诸层过滤的方式。单层的过滤间隙大有利于污水通过。多层过滤可有效的滤掉杂物，特别是长纤维容易堵塞下水道的杂物。本过滤丝清洁也比较方便，只需将其从下水道中抽出即可。
Patent CN-201391440-Y (CN)
Inventor: WEI XIE
IPC: F04B47/00
Filed: 2009-04-27
Granted: 2010-01-27
Abstract: 本实用新型涉及一种旁通抽油泵。包括上接头、上柱塞接头、上柱塞、上泵筒、上柱塞下接头、下柱塞、下泵筒、下接头和导流机构，其特征是导流机构包括排油接头、排油阀、排油管、进油接头、进油阀自上而下设置在泵体的外壁，其中，排油接头上端封堵，侧壁设有与上接头导通的偏心孔，上下两个排油阀分别设置在排油管与排油接头和进油接头的对接处，进油阀设置在进油接头的下部，并在下排油阀和进油阀之间的进油接头侧壁上设置导流孔，该导流孔与上泵筒和下柱塞之间的环形空腔导通。本实用新型改变了现有的抽油泵导流机构由泵筒内为泵筒外的结构形式，提高稠油的加热效率、降低热水使用成本，从而总体节约开采成本。
Patent CN-201351292-Y (CN)
Title: 一种用于挖掘机的黄油桶放置结构
Inventor: QINGHUA DAI
IPC: E02F9/00
Filed: 2009-01-08
Granted: 2009-11-25
Abstract: 本实用新型公开了一种用于挖掘机的黄油桶放置结构，包括一安装于挖掘机平台前侧主梁外侧的脚踏板，其特征在于：还包括一对安装于所述主梁外侧、所述脚踏板上方的卡合件及一固定带，所述固定带的两端分别与对应端的所述卡合件卡合固定，其与所述主梁、脚踏板围成容纳黄油桶的空腔，所述脚踏板的面积不小于黄油桶面积的三分之二。本实用新型通过在主梁外侧、脚踏板上方设置卡合件及一固定带，与所述主梁、脚踏板围成容纳黄油桶的空腔，使得黄油桶的放置更为方便，便于操作人员对黄油的加注。
Patent CN-201418055-Y (CN)
Inventor: XIANZHEN ZHOU
IPC: H02P5/747
Filed: 2009-04-01
Granted: 2010-03-03
Abstract: 本实用新型涉及一种库架双电机同步驱动定位控制机构，在库架两端左右滑架上分别安装两个交流异步电动机，所述两个电动机通过机械减速器连接驱动滑架行走的主动轮；滑架上的被动轮连接用于检测滑架实际行走距离的圆形编码器，所述圆形编码器的输出端连接库架行走机构控制器的输入端；两个交流异步电动机的控制端分别连接库架行走机构控制器，并同时通过数控变频调速器连接库架行走机构控制器；所述库架行走机构控制器还与主控计算机连接。本实用新型使用变频与闭环数控结合，使双电机驱动的库架变换库型迅速，行走平稳，定位精度高，系统运行安全可靠；库架行走机构简单、可靠且降低了生产加工成本；无牵引钢丝绳，设备安装后的场地整洁美观。
Patent CN-201366199-Y (CN)
Title: 高空作业安全带挂钩
Inventor: JUNLIAN XU
IPC: A62B35/00
Filed: 2009-03-06
Granted: 2009-12-23
Abstract: 本实用新型涉及一种高空作业安全带挂钩，其特征为钩体的开口处铰接锁杆，锁杆与钩体之间组装锁杆弹簧，在钩体上铰接保险杆，保险杆与钩体之间组装保险弹簧，在保险杆上开有带滑动销孔的锁槽，锁杆上固定滑动销，滑动销穿装在保险杆的滑动销孔内。只有先开启保险杆，才能打开锁杆，使用安全方便。
Patent CN-201363193-Y (CN)
Title: 一种高效率的摩托车发动机燃烧室
Inventor: DONGSHAO GUO
IPC: F02B23/00
Filed: 2009-02-25
Granted: 2009-12-16
Abstract: 本实用新型提供了一种高效率的摩托车发动机燃烧室，属于发动机领域。它解决了现有的摩托车发动机燃烧室火焰传播距离较小、紊流组织不够理想等问题。本高效率的摩托车发动机燃烧室布置在气缸头上且在燃烧室内设有排气门与进气门，所述的燃烧室内腔由两个圆球面及与两个与圆球面外切的斜曲面合围组成，两圆球面之间通过连接部相连接，所述的两圆球面均向内凹陷。本实用新型具有结构简单、火焰传播距离大、效率高等优点。
Patent CN-201363442-Y (CN)
Title: 双斜面平行闸板闸阀
Inventor: XIAOKE CHEN
IPC: F16K3/22
Filed: 2009-02-13
Granted: 2009-12-16
Abstract: 本实用新型公开了双斜面平行闸板闸阀，它包括手轮1，阀盖2，阀座3，阀杆4，阀杆4的底端连接有闸板5，闸板5为圆台状外形，闸板5外套有圆筒状密封面11，其密封面11的内接触面与闸板5的外接触面相配合，密封面11通过螺钉9与上盖10活动连接，密封面11的底端连接有底板7，密封面11内部上下分别设置有上定位销8和下定位销10，闸板5分别穿过上定位销8和下定位销10。本实用新型的有益效果：在阀门的启闭过程中阀门密封面之间磨损小，密封性能可靠，产品使用寿命长。
Patent GE-U1997142-Y (GE)
Title: Method for Modification of Natural Stone and Concrete Hardware
Inventor: MANASHEROVA VERA
IPC: C04B41/48
Filed: 1995-02-10
Abstract: This utility model refers to production of buil¬ding materials and it can be used for protection from damaging and for hardening stone, concrete brick by modification with highmolecular compounds. The technical result of the utility model is by modification with highmolecular compounds of mineral raw and hardware made from it, obtaining the improved having new physical and mechanical, properties, compositional, ecologically pure mineral-organic, high stability, frost resistance, stabile against biocorosion and aggressive environment, stabile against temperature changes from 60º C to 80º C, decorative (it doesn’t differ from granite, marble, malachite) and high wear resistant material. Method for modification of natural stone and concrete hardware provides for drying, impregnation with further polymerization, the polymerization is carried out in liquid inert environment by adding silicium, chromium and barium compound from the weight of monomer in the quantity of 0,5-4,0 % at 50-200ºC temperature according the type of hardware
Patent GE-U1999462-Y (GE)
Title: Method for Obtaining Robinine
Inventor: KEMERTELIDZE ETERI
IPC: A61K36/00
Filed: 1998-07-16
Abstract: 1. Technical Result Widening of raw-material base. 2. Essence Leaves of Pueraria hirsuta are extracted by 60-80% ethyl spirit, the extract is purified, crystallized, filtered and dried. 3. Field of Application Pharmaceutical industry, medicine.
Patent GE-U20061289-Y (GE)
Title: Organic-mineral bacterial fertilizers for treatment of legumes seeds
Inventor: BREGADZE VASIL
IPC: C05D9/02
Filed: 2005-06-09
Abstract: A fertilizer comprises active nitragin strains, gelatin, microelements and water in the following proportion of elements in mass %: gelatin 0,45 &nd  ash; 0,6 nitragin 5 x 10-7 – 6 x 10-7 micr  oelements 0,15 – 0,18 water the rest Tabl   es: 1
Patent MD-1252-Z (MD)
Title: Method for treating umbilical hernia in patients with liver cirrhosis
Inventor: PISARENCO Sergiu
IPC: A61K38/19
Filed: 2017-12-22
Abstract: The invention relates to medicine, in particular to surgery and can be used for treating umbilical hernia in patients with liver cirrhosis.Summary of the method consists in that 24…48 hours before surgical operation from the patient's blood is separated a suspension of mononuclear cells, containing 3×107 cells/mL and is performed the laparocentesis with the evacuation of 5…8 L of ascitic fluid with intraperitoneal introduction of 2 g of ceftriaxone and 200 mg of ciprofloxacin, also from the patient, 2…3 hours before the operation, are taken 30…40 mL of blood, which is centrifuged for 8…12 min at 3000…3500 rpm to produce a fibrin clot enriched with platelets. It is performed the operation, which consists in that are performed longitudinal or transverse incisions of the skin, subcutaneous tissue and aponeurosis, is mobilized to the cervix and is opened the hernial sac, is introduced its contents into the abdominal cavity and is removed the hernial sac, then is performed the abdominal wall defect plasty by the Sapezhko method with longitudinal duplication or Mayo with transverse duplication. Into the muscle layer around the plasty region, at a distance of 1 cm from its edges is administered the suspension of mononuclear cells, in an amount of 5…15 mL, after which on the performed plasty region is applied the fibrin clot and are sutured the subcutaneous tissue and the skin.
Patent MD-1278-Z (MD)
Title: Drying plant for granular products in suspended layer
Inventor: BERNIC Mircea
Filed: 2018-03-28
Abstract: The invention relates to the drying technique, in particular to drying plants for granular products in suspended layer, and can be used in food industry enterprises.The drying plant for granular products in suspended layer comprises a body (1) and a pipe (6). On the body (1) is rigidly mounted a control panel (3) for actuating an inverter (2) and a fan (4) for air suction by means of a filter (11), driven by an electric motor (13). On the fan (4) is mounted a pipe (6), to the lower part of which is attached a product loading sluice (5), driven by an electric motor (12). In the middle part of the pipe (6) is mounted a reflector (8), in which is mounted a magnetron (7), connected via a channel (16) to an additional reflector (14), in which is mounted a magnetron (15). In the upper part of the pipe (6) is mounted a product unloading pipe (9), and a cyclone (10).
Patent PE-20170210-Z (PE)
Title: Sistema de camara de calor pasivo para climatizacion de ambientes cerrados
Inventor: CHARCA MAMANI SAMUEL
IPC: B41J2/00
Filed: 2015-07-23
Abstract: La presente Invencion se refiere a un sistema para el aprovechamiento eficiente del calor pasivo, presente en sistemas de techo con cubierta externa a base de chapas metalicas o calamina. La inclusion de deflectores y un sistema que provoca movimiento de fluido genera turbulencia, de esta manera aumentando el proceso de transferencia de calor y almacenamiento. El invento propuesto supone la inclusion de los deflectores solidos con capacidad de almacenamiento de calor a base de materiales con capacidad de cambio de fase.
Patent ES-490943-A0 (ES)
IPC: G01N33/50
Filed: 1980-04-25
Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF<sub>1</sub> mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
Patent ES-509194-A0 (ES)
IPC: C07D501/24
Filed: 1982-01-29
Abstract: New cephalosporins of the general formula:    <IMAGE>  (I)  in which R is alkyl, L-2-amino-2-carboxyethyl, phenyl or various heterocyclic rings, R' is a hydrogen atom or a radical of the general formula: <IMAGE> (II)  and R DEG  is hydrogen, alkyl, vinyl, cyanomethyl or a carboxyalkyl radical of the general formula:    <IMAGE> (III)  and also their salts, their preparation and the pharmaceutical compositions in which they are present.
Patent ES-510552-A0 (ES)
IPC: C09B61/00
Filed: 1982-03-18
Abstract: Coloured polyethylene terephthalate moulding compound, a process for the preparation thereof and a container made therefrom. 
<??>A polyethylene terephthalate moulding composition is disclosed having uniformly dispersed therein 10-25,000 ppm of caramel as a colourant. The colourant is non-toxic, does not affect the transparency of the polyester, and does not cause aldehyde formation. The caramel may have been formed in situ from a mono- or disaccharide which has been added to the bis(beta-hydroxyethyl)terephthalate before or during polycondensation or to the molten polyester. The colour may have been intensified by additional supply of an alkaline reacting compound. The compostion may moreover contain further colourants. The composition if particularly suitable for use in the manufacture of food containers such a boxes, trays and bottles.
Patent ES-510560-A0 (ES)
IPC: A01N33/22
Filed: 1982-03-18
Abstract: 1. Compounds of formula  see diagramm : EP0061110,P11,F5  wherein A represents hydrogen, alkyl or alkenyl with up to 8 carbon atoms ; B represents hydrogen, methyl, acyl or CON(CH3 )2 ; A and B together may also represent an alkylene group with a total of 4 or 5 members, optionally interrupted by oxygen, or = CH - N(CH3 )2 ; Q represents oxygen or sulphur ; X, Y and Z, which may be the same or different, represent hydrogen, halogen, methyl, methoxy, trifluoromethyl, cyano, COOR or  see diagramm : EP0061110,P12,F1  R represents hydrogen, C1-5 alkyl or allyl ; R' represents hydrogen, C1-5 alkyl or allyl ; R and R' together may also represent an alkylene group with a total of 4 or 5 members optionally interrupted by oxygen.
Patent ES-524453-A0 (ES)
IPC: C07D471/04
Filed: 1983-07-26
Abstract: A 1-substituted-3-permissibly-substituted-6-oxodecahydroquinoline is converted to the corresponding 7-formyl derivative and then, upon treatment with hydrazine, may be cyclized to a tautomeric mixture of 5-substituted-7-permissibly-substituted-4, 4a, 5, 6, 7, 8, 8a, 9-octahydro-1H (and 2H)-pyrazolo [3,4-g] quinolines.
Patent ES-533487-A0 (ES)
IPC: B23Q41/02
Filed: 1984-06-15
Abstract: Work stations (PM1 to PM3, PA, PB) are connected in series or in parallel in a closed loop main conveyor circuit (CC), thereby constituting a modular "flexible workshop" type of installation. Each work station (e.g. PM1) includes an upstream read means (L11) and a write means (E12) for co-operating with a modifiable destination code incorporated in each pallet conveyed by the system. Each work station has a local data processor unit (UM1) associated with a keyboard-display device. The keyboard-display devices greatly facilitate setting up the modular installation whenever it is changed around, and also provide continuous monitoring of installation operation, including the work done by specific operators.
Patent ES-554266-A0 (ES)
IPC: A23F5/48
Filed: 1986-04-23
Abstract: A process for preparing a liquid aroma contain- ng concentrated coffee aromatic compounds from a grinder gas frost is described by treatment in a first oressure vessel and transfering a fraction to a second pressure vessel. A higher yield of coffee aromatics is enabled, and these aromatics are of a nigher quality. Further, the liquid aroma produced is essentially carbon dioxide free. The liquid aroma nay be used to aromatize coffee powders, glycerides or other food substrates. Coffee powders aromatized with the liquid aroma are described as laving a "buttery" "roasted and ground" coffee aroma.
Patent ES-557236-A0 (ES)
IPC: C07D471/04
Filed: 1986-12-01
Abstract: 5-(6-Imidazo[1,2-a]pyridyl)pyridine derivatives represented by general formula: wherein X represents hydrogen atom or methyl group; Y represents cyano group, carboxamido group, hydrogen atom, amino group or a halogen atom; Z represents hydrogen atom or a lower alkyl group; W represents hydrogen atom or a lower alkyl group; R' represents hydrogen atom, a lower alkyl group, phenyl group, a group shown by formula: -CH<sub>2</sub>R<sup>4</sup> in which R<sup>4</sup> is a lower alkoxy group, or a group shown by formula:in which R<sup>5</sup> and R<sup>6</sup> are hydrogen atom or a lower alkyl group; R<sup>2</sup> represents hydrogen atom or a halogen atom; and R<sup>3</sup> represents hydrogen atom, a lower alkyl group or a halogen atom; or a tautomer thereof; and pharmacologically acceptable salts thereof are disclosed. The 5-(6-imidazo[1,2-a]-pyridyl) pyridine derivatives are effective for treating congestive heart failures.
Patent FI-830404-A0 (FI)
Inventor: ZIERENBERG BERND
IPC: A61K9/70
Filed: 1983-02-07
Abstract: A novel process for the preparation of a pharmaceutical preparation in the form of an polyacrylate film for long-term transdermal administration of systemic pharmaceuticals comprising forming a homogeneous solution of an effective amount of a systemically acting pharmaceutical and a freeze-dried latex of a polyacrylate copolymer of methyl and/or ethyl esters of acrylic acid and methacrylic acid formed by emulsion polymerization and having an average molecular weight of about 800,000 in at least one organic solvent, forming a thin layer of the said solution and drying the layer to form a polyacrylate film and the film product produced by the said process.
Patent FI-830631-A0 (FI)
Inventor: RAUFAST CHARLES
IPC: C08F2/34
Filed: 1983-02-25
Abstract: The invention relates to a device and process permitting of the bottom drainage of a fluid-bed polymerization reactor (1) comprising a fluidization plate (2), a gas inlet (3) located between the said plate and the bottom of the reactor and a side pipe (4) located above the said plate and permitting of the evacuation of the fluidized particles, the said device consisting: of a vertical pipe (5) having a top opening at the level of the plate and a bottom end located outside and underneath the bottom of the reactor, which is occluded by a cock (6), and a gas intake tube (7) in the said vertical piping, leading out into the immediate vicinity of the said cock (6).
Patent FI-852786-A0 (FI)
Inventor: NEIDHARDT HELMUT
IPC: B32B7/12
Filed: 1985-07-16
Abstract: 1. Fabric provided as intermediate product for the production of a bulletproof laminate, said fabric consisting of aramide threads, other high modulus threads or, if necessary, of other synthetic threads, characterized in that at least at one surface of the fabric there is a thin layer of a binder from a thermoplast dry fixed, so that the binder layer (16) is arranged essentially only on the outer surfaces of the threads (12) and that the interior (22) of the threads is substantially free of binder.
Patent FI-874376-A0 (FI)
Inventor: LOHRBERG KARL
IPC: C25B9/19
Filed: 1987-10-06
Abstract: In an electrode assembly for gas-forming electrolyzers, particularly for monopolar membrane electrolyzers comprising vertical plate electrodes and opposite electrodes and a membrane between the plate electrode and the opposite electrode, the distribution of current in the membrane is improved and the voltage drop is decreased in that the plate electrodes are provided on that surface which faces the membrane with ante-electrodes, which consist of apertured, electrically conducting surface structures, which are electrically conductively connected to the plate electrodes and extend in planes which are parallel to the plate electrodes.
Patent FI-883651-A0 (FI)
Inventor: ZIJLSTRA ALBERT
IPC: A22C13/00
Filed: 1988-08-04
Abstract: A synthetic casing the outer surface of which is coated with a lubricant consisting of at least a hydrocarbon derivative which can be removed with water, such as a polyalkylene glycol or a mixture of paraffinic oil and an emulsifying agent. A process for preparing sausage comprising stuffing the above mentioned synthetic casing, which is coated with a lubricant, with a meat emulsion.
Patent FI-885746-A0 (FI)
Inventor: LEHMLER HANS-FRIEDRICH
IPC: B23K37/04
Filed: 1988-12-12
Abstract: The invention relates to a method for supporting beams which are laid on displaceable disc-shaped supporting rollers (17, 18) of a longitudinal conveyor. 
<??>In order to permit positionally stable support when conveying the various profile cross-sections and dimensions on a single longitudinal conveyor, the work pieces, which are in the form of U, I, L, T or bulb profiles are placed with their web faces (31) on the disc-shaped supporting rollers (17, 18) and their flanges (28) or bulbs facing downwards towards the disc-shaped supporting rollers (17, 18) and their flanges (28) are placed against abutment elements (24) arranged fixed perpendicularly to the bearing face of the disc-shaped supporting rollers (17, 18) in the direction of longitudinal conveyance. 
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Patent FI-902779-A0 (FI)
Inventor: DEAN GEORGE
IPC: C09J7/32
Filed: 1990-06-04
Abstract: A label laminate comprising a top sheet and a paper backing sheet, a coating of a pressure sensitive adhesive on one side of the top sheet, a release surface on one side of the paper backing sheet, the pressure sensitive adhesive being releasably laminated to the release surface to secure the top sheet and the paper backing sheet together, characterised by the paper backing sheet carrying on its other side a discontinuous coating of a remoistenable adhesive in the form of discrete dots of the adhesive deposited directly onto the paper backing sheet.
Patent FI-903709-A0 (FI)
Inventor: PORUCZNIK PAUL
IPC: B21D28/34
Filed: 1990-07-24
Abstract: When a blank is cut from metal sheet which suffers from crystallographic anisotropy, there is a tendency for ears to be formed during subsequent forming operations, such as drawing or pressing. In order to compensate for this tendency, there may be used a metal blank which is not completely round, but has lobes at positions to cancel at least some of the valleys between the ears. There is described a punch (110) and die (111) which may be used to form such a lobed blank (112). The punch (110) has four circumferentially extending lobe-forming sections (124). Each lobe-forming section is constructed by forming a stepped recess in the cutting edge of the punch (110). In each lobe-forming section, the depth of the recess varies from a maximum at the middle of the section to zero at the ends. The die (111) is conventional.
Patent FI-904304-A0 (FI)
Inventor: BAUMGARTEN HORST
IPC: G01N33/543
Filed: 1990-08-31
Abstract: For the detection of analytes with an immunological method by incubation with receptors and quantitation of complexes formed, at least one of the receptors used is a mixture of at least two monoclonal antibodies which are able to bind specifically to the analyte and which differ in cross-reactivity.
Patent FI-911309-A0 (FI)
Inventor: MEERE ANDREAS LEO JOHANNES DE
IPC: A61P15/00
Filed: 1991-03-18
Abstract: Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed. <IMAGE>
Patent FI-912285-A0 (FI)
Inventor: KANEKO TAKUSHI
IPC: A61K47/48
Filed: 1991-05-10
Abstract: The present invention provides novel N-substituted hydrazine bifunctional compounds, novel N-substituted hydrazone derivatives of a cytotoxic reagent incorporating the bifunctional compounds, novel conjugates containing at least one cytotoxic reagent molecule reacted with the bifunctional compound and bound to a molecule reactive with a target cell population, methods for their production, and pharmaceutical compositions and methods for delivering cytotoxic reagents to a target population of cells. The hydrazone bonds of the conjugates of the invention permit the release of free cytotoxic reagent from the conjugates in the acidic external or internal environment of the target cells. The bifunctional compounds, derivatives, conjugates and methods of the invention are useful in antibody-or ligand-mediated drug delivery systems for the preferential killing of a target cell population to treat diseases such as cancers, infections and autoimmune disorders.
Patent FI-935555-A0 (FI)
Inventor: BREU VOLKER
IPC: C07D409/12
Filed: 1993-12-10
Abstract: The novel compounds of the formula <IMAGE> in which R<1>-R<8>, X, Y and n have the meaning indicated in the description, are inhibitors of endothelin receptors and can be used for the treatment of disorders which are associated with processes increasing vasoconstriction.
Patent FI-935693-A0 (FI)
Inventor: YANAGISAWA HIROAKI
IPC: A61K31/41
Filed: 1993-12-17
Abstract: Compounds of formula (I) : <CHEM>  [wherein: A represents a group (IIa), (IIb) or (IIc) : <CHEM>   <CHEM> R<1> is alkyl, alkenyl, cycloalkyl or a group of formula R<4>-Y-R<5>-, where: R<4> is hydrogen, alkyl, or cycloalkyl, R<5> is a single bond or alkylene, and Y is oxygen, sulphur or imino group; R<2> is hydrogen, halogen, Optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R<3> is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula -CH=, -N= or -C(COOR<6>)=, where R<6> is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl]; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac iseases.