Patent SG-11201805253S-A (SG)
Title: Compositions and methods related to multimodal therapeutic cell systems for cancer indications
Inventor: KAHVEJIAN AVAK
IPC: A61K35/18
Filed: 2017-01-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 July 2017 (20.07.2017) WIPOIPCT (10) International Publication Number WO 2017/123646 A1 (51) International Patent Classification: A61K35/12 (2015.01) CI2N 5/10 (2006.01) A61K35/18 (2015.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2017/013035 11 January 2017 (11.01.2017) English (30) Priority Data: 62/277,130 11 January 2016 (11.01.2016) 62/359,448 7 July 2016 (07.07.2016) 62/370,915 4 August 2016 (04.08.2016) 62/420,973 11 November 2016 (11.11.2016) English US US us us (71) Applicant: RUBIUS THERAPEUTICS, INC. [US/US]; 620 Memorial Dr #100W, Cambridge, Massachusetts 02139 (US). (72) Inventors: KAHVEJIAN, Avak; 1 Memorial Drive, 7th Floor, Cambridge, Massachusetts 02142 (US). MATA- FINK, Jordi; 8 Windsor Rd #1, Somerville, Massachusetts 02144 (US). DEANS, Robert, J.; 1609 Ramsgate Court, Riverside, California 92506 (US). CHEN, Tiffany, F.; 91 Sidney St. Apt 207, Cambridge, Massachusetts 02139 (US). ROUND, John; 1 Memorial Drive, 7th Floor, Cam­ bridge, Massachusetts 02142 (US). AFEYAN, Noubar, B.; 1 Sunset Ridge, Lexington, Massachusetts 02421 (US). STRAIGHT NISSEN, Torben; 68 Waban Hill Rd., Chestnut Hill, Massachusetts 02467 (US). DOWDEN, Nathan; 4 Goddu Ave., Winchester, Massachusetts 01890 (US). WICKHAM, Tom; 20 Hickory Lane, Groton, Mas­ sachusetts 1450 (US). ELLOUL, Sivan; 114 Eastbourne Rd., Newton, Massachusetts 02459 (US). (74) Agent: KOYFMAN, Hannah, R.; Lando & Anastasi, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, Massachusetts 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) V© •t m CJ o CJ (54) Title: COMPOSITIONS AND METHODS RELATED TO MULTIMODAL THERAPEUTIC CELL SYSTEMS FOR CAN­ CER INDICATIONS (57) : The invention includes compositions and methods related to multimodal therapies, e.g., for treating a cancer. A mul­ timodal therapy described herein provides and/or administers a plurality of agents that function in a coordinated manner to provide a therapeutic benefit to a subject in need thereof, e.g., a subject having a cancer.