baber/WOPTO huggingface dataset:
Patent CA-2404712-A1 (CA)
Title: Synergistic methods and compositions for treating cancer comprising antiproliferative cytotoxic and cytostatic agents
Inventor: LEE FRANCIS Y
IPC: A61K31/555
Filed: 2001-03-22
Abstract: The present invention provides a synergistic method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective amount of: (1) at least agent selected from the group consisting of cytotoxic agents and cytostatic agents, and (2) a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present invention further provides a pharmaceutical composition for the synergistic treatment of cancer which comprises at least one agent selected from the group consisting of antiproliferative cytotoxic agents and antiproliferative cytostatic agents, a compound of formula (I), and a pharmaceutically acceptable carrier.
Patent CA-2405531-A1 (CA)
Title: Produits parfumes microencapsules et procedes d'enrobage de microcapsules
Inventor: HASHIZUME NOBUYA
IPC: A61M15/00
Filed: 2001-04-03
Abstract: L'invention concerne des dilatateurs de narines (11), des bandelettes (11), des procédés pour leur fabrication, ainsi que des procédés d'amélioration de la respiration d'individus. Les bandelettes (11) et les dilatateurs (11) comprennent un substrat oblong (30, 40), avec ou sans composant ou portion de dilatation (60), des surfaces supérieure (62) et inférieure (42) et un adhésif autocollant (32) disposé sur la surface inférieure. Le dilatateur peut être fixé sur le nez de l'utilisateur au moyen d'un adhésif. Ce dispositif comprend, en outre, une fragrance cosmétique, une médication aromatique ou une médication transdermique disposée sur les bandelettes destinées aux dilatateurs. De façon à améliorer la durée de vie ainsi que l'efficacité olfactive de tels produits, on utilise des mécanismes de libération de fragrance. On utilise aussi une séparation des huiles volatiles et des adhésifs afin de minimiser le résidu d'adhésif.
Patent CA-2410037-A1 (CA)
Title: 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
Inventor: LEWIS RICHARD THOMAS
IPC: A61P25/18
Filed: 2001-05-17
Abstract: A class of 3-phenylimidazo(1,2-a) pyrimidine derivatives (of Formula I, or salt or prodrug thereof : I) wherein Y represents a chemical bond, an oxygen atom, or a -NH- linkage; Z represents an optionally substituted aryl or heteroaryl group; R1 represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano trifluoromethyl, nitro, -ORa, -SRa, -SORa, -SO2Ra, -SO2NRaRb,-NRaRb, -NRaCORb, -NRaCO2Rb, -CORa, CO2Ra, -CONRaRb or -CRa=NORb; andRa and Rb independently represent hydrogen, hydrocarbon or a heterocyclic group.), substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, are selective ligands for GABAA receptors, in particular having good affinity for the a2 and/or a3 and/or a5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
Patent CA-2410368-A1 (CA)
Inventor: NAVARRO JEAN-CLAUDE
IPC: G01L1/22
Filed: 2002-10-31
Abstract: ABSTRACT        The hermetically sealed measuring sensor includes a monolithic proof body (1) having at its ends a first (2) and a second (3) non-deformable parts connected together by a central part designed as a deformable parallelogram. This central part of the proof body (1) has two through openings (6, 7) defining between them a main beam (10) of which at least one end is joined via a connecting section (13) to a measuring beam (12) which forms one piece with a non-deformable part (2, 3) of the proof body, but is uncoupled mechanically from the same. At least one of the non-deformable parts (2, 3) of the proof body has at least one cavity (4, 4', 22) of which one wall is formed by the measuring beam (12) and by two membranes (15) situated one on each side of this measuring beam (12). Strain gauges (17) are fixed inside the cavity (4) on the back of the measuring beam (12) and the cavity (4) is closed by a cover (20) which is welded, bonded, or fixed tightly to the corresponding non-deformable part (2, 3) of the proof body.
Patent CA-2411465-A1 (CA)
Inventor: CALLAHAN DANIEL E
IPC: C12Q1/04
Filed: 2001-06-07
Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular,  the present invention provides visual servoing optical microscopy, as well a s analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time: quantification  of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied ce ll stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of  cells.
Patent CA-2412901-A1 (CA)
Inventor: HANNA NABIL
IPC: A61P35/00
Filed: 2001-06-04
Abstract: The present invention provides a nucleic acid encoding IFN-.alpha. fusion proteins. The specification also describes the proteins encoded by said nucleic acids, methods of making IFN-.alpha. fusion proteins and methods of utilizing the compounds for the treatment of cancer. One specific IFN-.alpha.  fusion protein comprising IFN-.alpha. or a portion thereof capable of enhancing the killing ability of an effector cell and an anti-CD20 antibody, such as RITUXAN®, which can target, for example, B cell lymphomas e.g., non-Hodgkin's lymphoma).
Patent CA-2416376-A1 (CA)
Inventor: RENTSCHLER RICHARD W
IPC: B61D17/12
Filed: 2003-01-14
Abstract: A railroad car roof panel and skylight assembly. The assembly includes a rectangular metal roof panel. A pair of corrugations are formed in the roof panel with the corrugations extending longitudinally of the roof panel and spaced apart from one another transversely across the roof panel. A pair of light holes are formed in the roof panel between the corrugations. The light holes are positioned longitudinally of each other with each of the light-holes having an inner edge. A translucent plastic window is located above each light hole. Each transparent window has a shape similar to but larger than the shape of its light hole and is positioned to overlie the inner edge of its light hole. The transparent plastic window may be planar or dome shaped. A ring shaped gasket formed of an elastomer such as EPDM has an annulus of rectangular transverse cross section with a thickness greater than that of the translucent window. The gasket also has an integrally outwardly extending brim which is thinner than the annulus. An inwardly opening groove is formed in the annulus with the groove sized to receive an edge of the translucent plastic window. An annular clamp ring is positioned on the ring shaped gasket. The clamp ring has a first portion engaging the annulus and a second offset portion engaging the brim of the gasket. A series of swaged lockbolts extend through the metal roof panel and the clamp ring to clamp the gasket and translucent plastic window there between.
Patent CA-2417701-A1 (CA)
Title: Reinforced catheter and method of manufacture
Inventor: WILLARD MARTIN
IPC: A61M25/00
Filed: 2001-05-30
Abstract: A catheter shaft is disclosed that may reduce the thickness of the inner layer and/or allow the reinforcing layer to share the same space as the inner lubricious layer. In one illustrative embodiment, the inner lubricious layer is removed altogether, and an inner tubular braid member defines the inner lumen of the catheter shaft. In another illustrative embodiment, the inner lubricious layer and the reinforcing layer are effectively combined to form a reinforcing member. To combine the inner lubricious layer and the reinforcing layer, the wires used to form the reinforcing braid or coil are first coated with a lubricious polymer such as PTFE or PFA. When these strands are wound to form the tubular reinforcing member, the inner surface of the reinforcing member includes a lubricious surface. Various methods are also disclosed for providing a smooth inner surface for the catheter shaft.
Patent CA-2418219-A1 (CA)
Inventor: TELGMANN DIETER
IPC: D04H3/10
Filed: 2003-01-31
Abstract: A paper machine clothing, especially a press felt (1), includes a support (2) which has at least one layer of a thread lap (3, 4, 5, 13) and. which is embedded in a fiber matrix. Lap threads (6, 7, 8, 9, 10, 14, 17, 21, 25, 26, 27, 28, 33, 38, 43, 44, 45) run parallel to one another.  The lap threads (10, 14, 17) are provided with outwardly projecting fibers (12, 16, 19).
Patent CA-2418229-A1 (CA)
Title: Microbubble construct for sensitivity enhanced mr manometry
Inventor: DHARMAKUMAR ROHAN
IPC: A61K49/18
Filed: 2003-01-31
Abstract: The present invention provides microbubbles for sensitivity enhanced manometry, and more particularly the present invention relates to a magnetic resonance manometry method for measuring intravascular or intracardiac pressure using microbubbles of high magnetic susceptibility. The invention provides a microbubble for sensitivity enhanced magnetic resonance manometry, comprising a lipid shell having a high magnetic susceptibility. In one aspect the microbubble for sensitivity enhanced magnetic resonance manometry, comprising a lipid shell including magnetic nanoparticles having high dipole moments embedded therein.
Patent CA-2419339-A1 (CA)
Inventor: SCHWARZ HELMUT
IPC: F16B21/02
Filed: 2003-02-20
Abstract: Detachable insert connection arrangement (2) for a retaining channel (1) with a slot-type opening between two retaining edges, comprising a holder (2-1) and a push-in part (2-2) with a locking element (4) which can be pushed into the retaining channel. The locking element (4) can be turned around the axis of a rotation pin (B) and can, by means of a torsion spring, be brought into a locking position which bridges the slot (S) on the inside of the retaining edges (1-1, 2). The locking element (4) has two wings arranged in the form of a propeller. Each wing (4-1, 4-2) has a slide taper (SL), which, when the push-in part (2-2) is pushed into the retaining channel (1), is pressed against the edges of the slot in such a way that the locking element (4) can be turned against the force of a spring into a position where it can be pushed through the slot (S). In order to release the connection arrangement, the pin is turned against the force of the spring to bring the locking element (4) into a position enabling it to pass through the slot (S).
Patent CA-2420836-A1 (CA)
Inventor: POTTER TERRY A
IPC: C08K3/22
Filed: 2003-03-04
Abstract: The present invention relates to a composition containing A) a polymer, B) a pigment or a dye and C) ZnO as a stabilizer, wherein the initial CIELab value .DELTA.E of the stabilized pigmented polymer is less than compared to the pigmented polymer and the reduction of .DELTA.E of the stabilized pigmented polymer after 1500 kj UV radiation is at least 10% compared to the pigmented polymer.
Patent CA-2421120-A1 (CA)
Title: Quinolinone derivatives as tyrosine kinase inhibitors
Inventor: PECCHI SABINA
IPC: A61K31/19
Filed: 2001-09-11
Abstract: Organic compounds having the formulas I and II are provided [SEE FORMULA I] [SEE FORMULA II]     where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
Patent CA-2422233-A1 (CA)
Title: Interphenylene 7-oxabicyclic[2.2.1]heptane oxazoles as prostaglandin f2aantagonists
Inventor: GARST MICHAEL E
IPC: A61P9/10
Filed: 2001-09-07
Abstract: The present invention provides novel compounds represented by general formula (I). The novel compounds are PGF2a antagonists, useful in pharmaceutical compositions for treating PGF2a-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.
Patent CA-2423301-A1 (CA)
Title: Skin treatment composition and method based on the use of chromolaena odorata
Inventor: DONOVAN ROBERT MARK
IPC: A61K8/97
Filed: 2001-10-24
Abstract: A cosmetic method of providing at least one skin care benefit selected from treating or preventing wrinkling, sagging, aged and/or photodamaged skin; boosting decorin production in skin, boosting transglutaminase type I and ty pe III activity in skin, increasing stratum corneum flexibility, improving skin  desquamation and epidermal differentiation, lightening skin colour, controlling sebum secretion, soothing irritated, red and/or sensitive skin, improving skin texture, smoothness, firmness and generally increasing the quality of skincomprising an effective amount of an extract Chromolaena Odorata.
Patent CA-2425859-A1 (CA)
Inventor: PICCOLO GABRIELE
IPC: B23Q1/54
Filed: 2001-04-11
Abstract: A double-rotatable spindle head of non-perpendicular axis type for machine tools, with a first half-head (2) pivoted to the machine structure (4) about a first axis (10) and, for supporting the tool spindle (8), a second half-head (6) coupled to the first half-head (2) on a flat surface (20) and pivoted to it about a second axis (22) perpendicular to said flat surface (20), characterised by comprising a first direct motor (16, 18) for rotating said first half-head (2) with respect to said machine structure (4) and a second direct motor (28, 30) for rotating said second half-head (6) with respect to said first half-head (2).
Patent CA-2426886-A1 (CA)
Inventor: SUESS CHRISTIAN
IPC: H01R9/26
Filed: 2003-04-25
Abstract: In a connection system (1) with a current bar (4) and a contact foot (2,2') as well as a clamping element (3,3') and a bearing bar (6) with an edge (6a) behind which the clamping element (3,3') reaches, for purposes of simplifying production, the contact foot (2,2') is held at the current bar (4) by means of a resilient clamp connection.
Patent CA-2427645-A1 (CA)
Inventor: POSTON LUCILLA
IPC: G01N33/74
Filed: 2001-11-02
Abstract: La présente invention se rapporte à une méthode permettant de prévoir la pré-éclampsie (PE). Cette invention traite également d'un matériel de diagnostic permettant de mettre en oeuvre la méthode de prévision de la PE. En particulier, cette méthode permet de déterminer le niveau de deux marqueurs ou davantage choisis parmi un facteur de croissance placentaire (PlGF), un inhibiteur de type 1 de l'activateur du plasminogène (PAI-1), un inhibiteur de type 2 de l'activateur du plasminogène (PAI-2), et la leptine.
Patent CA-2430859-A1 (CA)
Inventor: WADA HIROO
IPC: B01J20/286
Filed: 2003-06-03
Abstract: A carrier for chromatography or a carrier for a pre-treatment comprises a carrier material consisting of a or a metal compound reactive with the sulfur-containing compound or a carrier material whose surface is coated with the foregoing metal or metal compound; and a sulfur-containing compound bonded to the surface of the foregoing carrier material and a kit for preparing a carrier for chromatography or a carrier for a pre-treatment comprises the foregoing carrier material; and a sulfur-containing compound. This carrier has a hydrophobic field established by groups such as octadecyl groups, which is never elimated therefrom even under acidic and alkaline conditions; has thus a high separation power and a long service life; can easily be prepared within a short period of time; and therefore, the production cost thereof is quite low.
Patent CA-2431483-A1 (CA)
Inventor: STANISLAWSKI PAULINE
IPC: A61K31/454
Filed: 2001-12-18
Abstract: La présente invention concerne des composés de formule (I), leurs sels et les dérivés correspondants acceptables sur le plan pharmaceutique, les compositions pharmaceutiques renfermant ces composés et leur utilisation dans le traitement d'infections au picornavirus chez des mammifère, ainsi que de nouveaux intermédiaires utilisés dans la préparation de composés de la formule (I).
Patent CA-2434140-A1 (CA)
Inventor: KANEKO YASUHIRO
IPC: F01M13/00
Filed: 2003-06-02
Abstract: A blowby gas circulation system for an engine having a crankcase and an intake system comprises an oil tank which is independently of the crankcase, a first breather chamber and second breather chamber which are integrally provided with the crankcase. The oil tank supplies engine oil reserved therein to the crankcase and introduces a first gas-liquid mixture generated in the crankcase. The first gas-liquid mixture is separated into a second gas-liquid mixture and engine oil in the oil tank. Then, the second gas-liquid mixture is sent to a first breather chamber, being separated into a third gas-liquid mixture and engine oil. The third gas-liquid mixture is sent to a second breather chamber in which the third gas-liquid mixture is separated into blowby gas and engine oil. The blowby gas is sucked into the intake system and the engine oil is returned to the crankcase.
Patent CA-2435628-A1 (CA)
Inventor: BEST ISAAC WM
IPC: A63B57/00
Filed: 2003-07-28
Abstract: "The Handicapped Golf Systems" are comprised of an exclusive technology that gives a visually impaired person, a mentally challenged person and a physically disabled person the ability to learn to play golf, by having a solution to every conceivable problem incorporated into the systems. The core device, called the C-FAB unit defies the sport related saying, "you can't hit em, if you can't see em".
Patent CA-2437510-A1 (CA)
Inventor: DRUCK PHILIP
IPC: H03H17/02
Filed: 2002-01-04
Abstract: An N dimensional signal processor using D scale non-uniform sampling is disclosed. The processor includes a multi-resolution sampler (A) for outputting a stream of non-uniformly spaced samples resulting in an overall average sampling rate sufficient to satisfy Nyquist criteria to reconstruct the signal, a filter bank router (B) for mapping each point in the output stream to a filter in a filter bank, a digital filter bank (C) where each filter in the bank does filter of a subset of the samples at different uniform rates such taht the stream is uniformly spaced, and a consolidator (D) for consolidating or interleaving uniformly spaced streams form the filters into one non uniformly spaced stream.
Patent CA-2437893-A1 (CA)
Title: Procede et appareil de commande de puissance dans un systeme de communication sans fil
Inventor: LUNDBY STEIN A
IPC: H04B7/005
Filed: 2002-02-06
Abstract: L'invention concerne un procédé et un appareil pour commander la puissance des ordres de commande de puissance transmis sur une liaison aval dans un système de communication sans fil (20). Le niveau de puissance des bits de commande de puissance sur la liaison aval est adapté en fonction des ordres de puissance reçus sur la liaison inverse. La station mobile mesure le niveau de puissance des bits de commande de puissance adaptés pour évaluer la qualité de la liaison aval.
Patent CA-2438745-A1 (CA)
Title: Metal-containing dendrimers
Inventor: LUPTON JOHN MARK
IPC: C08G83/00
Filed: 2002-02-20
Abstract: A light emitting device which comprises at least one layer that contains an organometallic dendrimer with a metal cation at its core.
Patent CA-2438747-A1 (CA)
Inventor: BOONE BRIAN T
IPC: B62B1/06
Filed: 2003-08-25
Abstract: An apparatus for transporting a car seat such as an infant car seat, child car seat, or a child booster seat is disclosed. The apparatus includes a carrier body and at least one system of harnesses for attaching a wheeled assembly to the car seat. The apparatus with attached car seat may be wheeled on the ground by a person using one hand, or may be carried on a person's back, chest, or side, leaving the person's hands free. The system of harnesses may include an upper harness system, a middle harness system, a shoulder harness system, and a hip harness system. The wheeled assembly may also be attached to the carrier body via a system of attachment straps, including an upper attachment system, middle attachment system, and lower attachment system. The apparatus permits a person to wheel or carry the car seat together with a child secured in the car seat.
Patent CA-2441103-A1 (CA)
Title: Polyimide adhesion enhancement to polyimide film
Inventor: ZIMMERMAN SCOTT M
IPC: H05K3/06
Filed: 2002-03-11
Abstract: The invention relates to the manufacture of printed circuit boards having improved interlayer adhesion. More particularly, the present invention pertains to adhesiveless printed circuit boards having excellent thermal performance and useful for producing high-density circuits. A metal foil coated with a polyimide film is laminated onto an etched surface of a polyimide substrate. Etching the substrate surface allows for strong adhesio n of a pure polyimide film to the substrate.
Patent CA-2441858-A1 (CA)
Title: Derives d'arylisoxazoline, leurs procedes de production et leur utilisation comme pesticides
Inventor: ECKHARDT MATTHIAS
IPC: C07D413/10
Filed: 2002-03-09
Abstract: L'invention concerne des composés de formule (I), dans laquelle les symboles et indices ont la signification suivante : les groupes X sont identiques ou différents et représentent a) halogène, cyano, nitro; b) alkyle (C¿1?-C¿4?), alcoxy (C¿1?-C¿4?), alkylthio (C¿1?-C¿4?), alkylsulfinyle (C¿1?-C¿4?), les restes du groupe b étant éventuellement substitués par un ou plusieurs, de préférence par un, deux ou trois restes du groupe halogène ; les groupes R?1¿ sont identiques ou différents et représentent halogène, halogénure d'alkyle (C¿1?-C¿4?), alkyle (C¿1?-C¿4?), alcoxy (C¿1?-C¿4?), halogénure d'alcoxy (C¿1?-C¿4?) ou cyano ; m vaut 0, 1, 2 ou 3 ; n vaut 1, 2, 3, 4 ou 5 ; Z représente oxygène, soufre, CH¿2? ou NR?2¿ ; R?2¿ représente CN, alcoxy (C¿1?-C¿4?) alkyle (C¿1?-C¿4?), CHO, alkylcarbonyle (C¿1?-C¿6?), alcoxycarbonyle (C¿1?-C¿6?) ou (CW)NR?3¿R?4¿ ; R3, R?4¿ sont identiques ou différents et représentent H, alkyle (C¿1?-C¿6?) ; W représente O ou S ; G représente une isoxazoline substituée une à quatre fois, de préférence une ou deux fois, qui est reliée en position 3, 4 ou 5, au noyau phényle adjacent. L'invention concerne également les isomères purs (isomères optiques et géométriques), des mélanges d'isomères et des N-oxydes de ces composés, qui, comme ces derniers, s'utilisent en tant que pesticides.
Patent CA-2442214-A1 (CA)
Inventor: TAE WOO YOO
IPC: A61B17/04
Filed: 2003-09-24
Abstract: A hand acupuncture needle assembly according to the present invention comprises an acupuncture needle including a body, and a fine point at a bottom thereof, and a tube type grip element extending over a portion of the acupuncture needle, and at least a substantial length of the tube type grip element being compressed such that an outer surface of the acupuncture needle is fixedly connected with an inner surface of the at least a substantial length of the grip element.
Patent CA-2442742-A1 (CA)
Title: Quinazoline derivatives
Inventor: ABE DAISUKE
IPC: A61P9/10
Filed: 2002-02-21
Abstract: Compounds represented by the following general formula (I): (I) pharmaceutically acceptable salts thereof, hydrates or solvates of the same or mixtures of optically active isomers, racemic compounds or diastereomers of the same which have an excellent protein kinase inhibitory activity specific to tyrosine and, therefore, are usable as drugs, in particular, remedies/preventives for various cancers, diseases caused by arteriosclerosis or psoriasis.