baber/WOPTO huggingface dataset:
Patent DO-P2018000005-A (DO)
Title: Compuestos inhibidores de la señalización de la vía de notch
Inventor: PHILIP ARTHUR HIPSKIND
IPC: C07D487/14
Filed: 2018-01-05
Abstract: La presente invención proporciona compuestos, o una sal farmacéuticamente aceptable de estos, y una composición farmacéutica que contiene dichos compuestos o una sal farmacéuticamente aceptable de esta, útil como un inhibidor de la señalización de la vía Notch para el tratamiento de los cánceres nombrados, pérdida de audición neurosensorial causada por la pérdida de células ciliadas auditivas, e inducción de la generación de células ciliadas auditivas.
Patent EC-SP12011629-A (EC)
Title: Fulvestrant en una dosis de 500 mg para el tratamiento del cáncer de mama avanzado
Inventor: DIMERY ISAIAH WILLIAM
IPC: A61P35/00
Filed: 2012-01-27
Abstract: La presente invención se refiere a fulvestrant en una dosis de 500 mg para utilizar en el tratamiento de una mujer posmenopáusica con un cáncer de mama avanzado que ha sufrido un avance o una recidiva durante la terapia endocrina.
Patent EC-SP13012483-A (EC)
Title: Derivados de 6-cicloalquil-1,5-dihidro-pirazolo(3,4-d) pirimidin-4-onas y su uso como inhibidores de pde9a.
Inventor: EICKMEIER CHRISTIAN
IPC: C07D487/04
Filed: 2013-03-07
Abstract: La invención se refiere a nuevas 6-cicloalquil-pirazolopirimidinonas según la fórmula (I). (I),en donde R1 es un grupo heteroarilo aromático de 5 o 6 eslabones, R2 es un sustituyente opcional, D es ciclopentilo, ciclohexilo, tetrahidrofuranilo, tetrahidropiranilo o 2-, 3- o 4-piridilo, opcionalmente sustituidos, m = 1 o 2 y n es 0, 1 o 2. Los nuevos compuestos son para usar como la entidad activa de medicamentos o para la fabricación de medicamentos respectivamente, en particular medicamentos para el tratamiento de estados relacionados con déficits en la percepción, concentración, aprendizaje o memoria. Tales estados pueden por ejemplo estar asociados con la enfermedad de Alzheimer, esquizofrenia y otras enfermedades. Los nuevos compuestos son también por ejemplo para la fabricación de medicamentos y/o para uso en el tratamiento de estas enfermedades, en particular para el impedimento cognitivo asociado con dicha enfermedad. El compuesto de la invención muestra propiedades inhibitorias de PDE9.
Patent EE-200300394-A (EE)
Inventor: EGLE IAN
IPC: C07D409/00
Filed: 2002-02-15
Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:or a pharmaceutically acceptable salt thereof.
Patent GB-189508215-A (GB)
Title: Improvements in the Manufacture of Imitation or Artificial Leather.
Inventor: SCHMIEDEL HERMANN
Filed: 1895-04-25
Granted: 1896-03-14
Abstract: 8215. Schmiedel, H. April 25. Coated fabrics.-A layer of linen or cotton fabric is glued to a lining of strong paper, and is provided with a coating of water or aniline colours, with animal glue, shellac, albumen, casein, tannin, &c. The surface is smoothed or embossed in any required manner by calenders or goffering-cylinders.
Patent GB-189701678-A (GB)
Title: Improvements in Apparatus for Breaking Stone and other Mineral Substances.
Inventor: WHITAKER THOMAS
Filed: 1897-01-21
Granted: 1897-12-04
Abstract: 1678. Whitaker, T. Jan. 21. Crushers with vibrating jaws for stone and minerals. A connecting-rod G, Fig. 1, embraces the crank shaft D and carries two toggles H, K, the one pivoted to the movable jaw and the other to an adjustable spindle k, whereby a double stroke and a positive return movement is imparted to the said jaw. In the form shown in Fig. 3, the driving-shaft acts upon a movable jaw by means of a link H<1>, adjustable pin N, and wedge L<1>.
Patent GB-189702179-A (GB)
Title: Improvements in and connected with Rims and Tyres for the Wheels of Velocipedes, Motor Cars, and other Vehicles.
Inventor: MADIGAN JOHN
Filed: 1897-01-27
Granted: 1897-05-29
Abstract: 2179. Madigan, J. Jan. 27. Tyres, pneumatic; felloes or rims.-To the edges of the cover are attached non extensible beadings B, B of oval or like section, which are placed in grooves H, H in the rim. These beadings preferably project further on the outer side of the tyre than on the inner. Single-tube tyres may be attached in a similar manner. As shown in Fig. 1 the grooves may be in the inner face of the rim. In the case of a tubeless tyre, the material y forming the air chamber may have abutting scarf-jointed or overlapping edges X, Z as shown in Fig. 2.
Patent GB-189707489-A (GB)
Title: Improved Brake Mechanism for Velocipedes.
Inventor: MILTON WILLIAM
Filed: 1897-03-23
Granted: 1897-04-24
Abstract: 7489. Milton, W. March 23. Brakes are constructed to be applied by hand or foot power, or both. A brake roller F, G is carried between cone bearings e, e<1>, E, supported by levers C pivoted to clamps B attached to the fork sides. The levers C are raised and lowered to apply and remove the brake by means of a fork D connected to the usual brake plunger D' and provided with foot-rests H.
Patent GB-189708229-A (GB)
Title: Improvements in Muffle Furnaces.
Inventor: DAMOUR EMILIO
Filed: 1897-03-30
Granted: 1898-02-19
Abstract: 8229. Damour, E., and Adnet, E. March 30. Muffle furnaces.-Liquid or gaseous fuel is employed to heat two muffles d<1>, d, arrauged at different levels. The air supply is heated by the waste products of combustion. The gases from the burners l, l<1> pass round the arch g, and enter the space between it and the muffle d<1>. Thence they descend and heat the muffle d, and escape round the serpentine coil b, b<1> through which air to support combustion is passed on its way to the chambers B and apertures n, n.
Patent GB-189711527-A (GB)
Title: A New or Improved Driving Gear for Cycles.
Inventor: GRANT THOMAS
Filed: 1897-05-08
Granted: 1898-04-02
Abstract: 11,527. Grant, T. May 8. Driving-mechanism for bicycles, tricycles, &c. In the form shown in Fig. 1, a toothed wheel D, keyed to the crank axle d, drives a pinion E secured to an eccentric sheave C. A band B mounted in ball bearings on the sheave is connected by a frame A to a band B' mounted on a similar eccentric sheave C<1> secured to the driving-wheel hub H. The frame A has a slot g which engages a pin g' carried by the cycle frame. In a modification shown in Fig. 2, an eccentric sheave C on the crank axle drives through bands B and B<1> connected by a rod A a sheave C' loosely mounted on the driving-wheel hub. An internal wheel D secured to the sheave C conveys the motion through a star-wheel F to a pinion E keyed to the wheel hub. The Provisional Specification states that hand-levers may be used to assist the driving-mechanism.
Patent GB-189713011-A (GB)
Title: Improvements in Shirt-cuff Holders.
Inventor: WARD HENRY
Filed: 1897-05-27
Granted: 1898-05-27
Abstract: 13,011. Ward, H., Hogg, D. C., and Mitchell, C. H. May 27. Cuff s u s p e n d e r s; shirts.-A buttonhole tab B is sewn to the shirt sleeve, and when fastened to a button or stud C fixed near the cuff serves to withdraw the cuff into the coat sleeve.
Patent GB-189714107-A (GB)
Title: Improvements in Rotary Engines or Pumps.
Inventor: MORGAN DAVID
Filed: 1897-06-09
Granted: 1897-07-10
Abstract: 14,107. Morgran, D. June 9. Crescent - shaped chamber type. - A rotary drum or piston D with sliding vanes E is eccentrically mounted i the cylinder A. Stepped or other annular grooves a<2>, formed concentric with the cylinder A, receive corresponding projections e<3> on the vanes E and control their sliding movement. The vanes and vane bearings may be provided with balls and antifriction rollers ; the packing F at the point of contact of the piston D with the cylinder A may be either held against the piston by the pressure of the motive fluid or adjusted by screws f.
Patent GB-189722431-A (GB)
Title: Improvements in or relating to Motors for the Propulsion of Cycles, Cars, Carriages, Vans, or other like Machines or Vehicles.
Inventor: EDWARD THOMAS SENIOR
Filed: 1897-09-30
Granted: 1898-09-30
Abstract: 22,431. Senior, T. E. Sept. 30. Turbines.-Relates to a hydraulic or a hydraulic and pneumatic motor for propelling cycles, cars, carriages, vans, &c. The bed-plate A comprises a water-storage reservoir. The water is pumped by a hand pump D or a pump F driven by the motor H into the reservoir E, whence it is supplied to the motors H and K. Air is similarly pumped up by the hand-pump E<1> and power pump G to the reservoir E, and is likewise fed to the motors. The motor K actuates the driving-shaft of the vehicle through worm gearing P, P<1>. It is shown in section, Fig. 5, and comprises two wheels fixed to the shaft K<4> separated by a disc, and with blades K<5> arranged to be acted on in opposite directions by the water that enters through the ports K<9> or K<10> and the air supplied by the pipes L. A single handle M controls the two valves K<7>, K<8>. The exhaust water and air escape through N to the tank in the Led-plate. The motor is described applied to a tricycle.
Patent GB-189724272-A (GB)
Title: Improvements in or relating to the Construction of Half-side Rail- or Children's-Bedsteads.
Inventor: PEYTON BERNARD RICHARD
Filed: 1897-10-20
Granted: 1898-09-03
Abstract: 24,272. Peyton, B. R. Oct. 20. Cots.-The half side frames b are hinged to the bottom at b<x>, and have projections b<2>, which are engaged with eyes or slots on collars c, and are secured by thumb-nuts &c. The frames may be hinged to the head frame, and be detachably secured to the bottom.
Patent GB-189727639-A (GB)
Title: Improvements in and connected with the Preparation of Calcium Carbide for use in the Production of Acetylene Gas.
Inventor: LAZARUS WILLY JOSEF HUBERT
Filed: 1897-11-24
Granted: 1898-08-27
Abstract: 27,639. Lazarus, W. J. H. Nov. 24. Parcelling carbides.-Calcium carbide, or any mixture thereof with paraffin &c. for the generation of acetylene, is powdered and packed in metal containers closed at the end by paraffin, wax, stearine, or gelatine, treated to make it waterproof, or in envelopes of the latter materials.
Patent GB-189801431-A (GB)
Title: Method for the Preparation of Azo- and Azoxy-aldehydes.
Inventor: GREEN ARTHUR GEORGE
Filed: 1898-01-18
Granted: 1899-01-07
Abstract: 1431. Green, A. G., and Meyenberg, A. Jan. 18. Dyes, artificial.-Relates to the preparation of azo and azoxy compounds containing aldehyde groups by oxidizing stilbene colouring-matters such as curcumine, chrysopenine, Hessian yellow, Mikado orange, &c. by means of a quantity of permanganate small enough to be immediately decolorized. The aldehyde got from curcumine is a nearly-colourless, readily-soluble substance which (a) is readily precipitated by salt from aqueous solution, (b) is taken up by wool from a boiling acid bath, the wool being capable of subsequent development to a deep orange colour, by immersion in a dilute acetic-acid solution of phenylhydrazine, (c) forms a phenyl-hydrazide darker in colour than that of nitrobenzaldehyde sulphonic acid, and gives a bluish-green solution in concentrated sulphuric acid.
Patent GB-189805045-A (GB)
Title: Improvements in Photographic Cameras.
Inventor: ANGEL ANDREA
Filed: 1898-03-01
Granted: 1898-05-07
Abstract: 5045. Angel, A., and Angel, L. V. March 1. Change-boxes cameras.-Relates to a film or plate changing device of the escapement type. In Fig. 2 it is shown fitted in a hand camera. The films or plates, alternating with loose cardboard backings, are packed in the magazine A. These run on central guiding-ridges a, a<1>, the cards having a pair of notches on each side, through which the pins e, e pass when they are brought together by the action of the inclined cam slots g<1>, g<2> on the vertically-sliding plates to which the pins are fixed. The slots g<1>, g<2> and the slot g are all in two longitudinal plates G, which can be moved to and fro by the external projection G<2>. The forward movement of the plate G lifts the hinged abutment frame D and separates the pins e, e<1>, so that the front film can fall forward on to the cloth screen I attached to the frame D and the bottom of the camera. The backward movement of G brings the pins e, e together so that the front backing can fall out, and then folds down the frame D on to the face of the next following film. A catch H retards G to give the backing time to fall. A counter is actuated by the sliding plate G.
Patent GB-189806168-A (GB)
Title: Improved System of Displaying Numerical Quantities for Stock-keeping Purposes and the like.
Inventor: COTTERELL MORTON BLENCOWE
Filed: 1898-03-14
Granted: 1899-01-21
Abstract: 6168. Cotterell, M. B., and Ebbutt, P. G. March 14. Receipts, checking and recording.-Relates to a means for indicating the state of a shop's stock and the like. In a locked casing, with a glazed door a', is placed a sheet of soft material such as felt and over it a sheet of paper or cardboard e ruled into rectangles for the different sorts of stock and marked with the normal amount to be kept and with numbers representing, say, dozens and units. Pins g, g<2> are inserted at the end of each day by the stock-keeper opposite the numbers representing stock in hand and stock on order, the pins being distinguished by their shape.
Patent GB-189806354-A (GB)
Title: Improvements in the Manufacture of Casks.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1898-03-15
Granted: 1898-08-13
Abstract: 6354. Thompson, W. P., [Sauter, G.]. March 15. Wood casks, making, for highly-fermented beer and other liquids under pressure. The inner casing consists of a veneer or thin sheet a which is bent into shape by winding round a core C, C<1>, Fig. 2. The end of the sheet being clamped under a bar b, the sheet is pressed to the core by a heated roller F, and then the ends, which are bevelled, are glued together. To attach the ends together, a screw clamp is used which is let into a recess in the core that is normally covered by a strip c. To remove the sheet a, the core is collapsed by withdrawing the wedge D. On the shell a shouldered ends A<2> formed of veneer and strips of cloth, or of a thick board, are placed. Further layers of veneer and fabric e<2> are attached to the shell a. With this view the shell is placed on the stand S, Fig. 14, and, a sheet of veneer being placed on the top, the hollow cover t, t<1> of zinc is placed over the veneer and attached to the stand. Water under pressure is then admitted to the cover to attach the sheet. The projecting ends of the sheets e' are bent over the ends, for which an apparatus adapted to press the ends by water under pressure is used. Bands of veneer F', F<2> are then put on. To effect this, the cask clamped between the shafts K, K, Fig. 21, is rotated while the band k is fed to it, being guided by a reel T restrained by a brake. An outer cover U is finally put on and the ends A', being strengthened by laths B<3>, are covered by discs C'. The space between the inner and outer covers is used for cold or compressed air or gas &c. as may be found most suitable in view of the contents of the cask.
Patent GB-189815785-A (GB)
Title: Improvements in Switches for Electric Circuits.
Inventor: BELFIELD REGINALD
Filed: 1898-07-19
Granted: 1899-05-20
Abstract: 15,785. Belfield, R., [Scott, C. F., Davis, H. P., and Wright, G.]. July 19. Switches for varying the active length of a conductor. This is divided into two (or more) parts, one of which is divided into a number of units which can be inserted one by one. When all are in, an undivided section is inserted instead of the divided, and then the separate units can again be inserted one by one. This system is applicable to resistances, coils of transformers, &c. Figs. 1 and 2 show a switch for varying simultaneously the number of coils or turns of the two primaries of a transformer or transformers for two-phase currents. Two insulating-plates 3, 3<a>, mounted in a frame 1, are fitted with contacts 4, 4<a>, connected to the divided sections of the coils. The switch arms 8, 8<a> are moved step by step over the contacts by the handle 28 through ratchet gearing, 29, 19, and 29<a>, 19<a>, &c. The projecting end 24 of the handle lever carries a spring-controlled pawl 36 which works over a rack 40 fitted with stops 40<a> so arranged that the handle cannot be rocked backwards until the stroke has been completed. The switch arms are fitted with auxiliary sparking contacts 13, 13<a>. The substitution of an undivided section for a divided section is effected by an auxiliary switch 47, which has slotted extensions 48, adapted to be engaged by rollers 14, 14<a> carried on extensions of the switch arms. To determine the direction of rotation of the ratchet-wheels, the pawls 29, 29<a> are connected by springs 33, 33<a> to pins carried by the upper part 25 of the switch handle, which can be partially rotated axially to vary the position of the pawls. To prevent the switch arms from passing their limiting positions, the coupling-discs 17, 17<a> have cut-away recesses adapted to receive the ends of pivoted stops carried by the ratchet-wheels the free ends of which engage with pins carried by the locking-arms 41, 41<a>. In a modified construction, the two sets of contacts &c. are carried on one disc, and the switch arm is correspondingly modified.
Patent GB-189816687-A (GB)
Title: Improvements in Valve Gear for Internal Combustion Motors.
Inventor: CROSSLEY WILLIAM JOHN
Filed: 1898-08-02
Granted: 1899-06-24
Abstract: 16,687. Crossley, W. J., and Atkinson, J. Aug. 2. Gas and like engines, valve gear for. To open a valve rapidly, and to avoid the excessive strain on the gear produced by the operation, a resilient valve lever is employed. In Fig. 1, a flat spring C on the lever B is gradually pressed against the exhaust-valve stem A until the pressure is sufficient to overcome the pressure in the cylinder, or until the spring is pressed against the set-screw E, when the valve is suddenly opened. A spiral spring may be substituted for the flat spring. The invention is particularly applicable to large engines.
Patent GB-189817778-A (GB)
Title: Improvements in and connected with Steam and like Engines.
Inventor: HUNT EDMUND
Filed: 1898-08-18
Granted: 1899-07-08
Abstract: 17,778. Hunt, E. Aug. 18. Planing and shaping.-Fig. 5 shows a tool-holder for planing or shaping each half of the piston chamber of an annular-chambered rotary steam or like engine. The holder S is mounted on studs S', S' engaging diagonal grooves in worm-wheels T, T<1>, turned together by worms V, V<1>.
Patent GB-189820267-A (GB)
Title: Improvements in Combined Turntables and Weighbridges.
Inventor: LEWIS JOHN JENKINS
Filed: 1898-09-24
Granted: 1899-07-29
Abstract: 20,267. Lewis, J. J. Sept. 24. Turntables.-A combined turntable and weigh-bridge is shown in section in Fig. 2. The platform b is carried by radial arms c, fitted at their ends with rollers d, which run on a circular track e. The track is preferably supported, by the brackets e<1>, on four Y-shaped levers h. The outer ends of these levers are hung from standards n, and their inner ends are pivoted at k<1> to a lever j. The lever is pivoted at one end eccentrically to the centre of the turntable, and is connected at the other end to an ordinary steelyard.
Patent GB-189822867-A (GB)
Title: Improvements relating to Marquetry and Inlaid Work.
Inventor: DUNSKY ALFRED
Filed: 1898-10-31
Granted: 1899-03-18
Abstract: 22,867. Dunsky, A. Oct. 31. Marquetry and inlaid work.-In the arrangement shown in Fig. 2, a transparent or translucent filling or design a of celluloid, horn, or the like is painted or coloured on the back, and secured within a wooden plate b which has the design sawn out so as to form bevelled retaining-edges. In a modification shown in Fig. 4, a design or pattern of ivory, brass, or ornamental material b is secured within a transparent perforated plate a, which is backed with a layer c of metal, coloured fabric, &c. Several layers of wood are glued on the back of the inlaid work, and the face is planed, polished, stained, varnished, &c.
Patent GB-189823074-A (GB)
Title: Improved Apparatus for Drawing Off and Checking a Measured Quantity of Liquid.
Inventor: HIRSCHI EMILE
Filed: 1898-11-02
Granted: 1899-01-14
Abstract: 23,074. Hirschi, E. Nov. 2. Measured quantities, delivering.-The measuring- vessel R is, in the normal position of the parts, filled from the pipe E up to the level of the air cut-off valve C. When the liquid is to be discharged, the lever L is pressed, actuating a counter B by a slip-pawl, and raising the discharge, supply cut-off, and air-inlet valves S, S<1>, e These valves are attached to a rod T, and the return of the parts, after the liquid has been delivered, is effected by a spring r.
Patent GB-189902536-A (GB)
Title: Improvements in Drain or Sewer Gratings with Lock-up Covers.
Inventor: MUNRO EDWARD MAY
Filed: 1899-02-04
Granted: 1899-07-22
Abstract: 2536. Munro, E. M., Brecknell, H., and Rogers, H. I. Feb. 4. Fastenings, screw, for manhole covers and trap gratings &c. The grating A is held down by a screw D, which enters a recess E formed for it in the frame B. The nut F may be moulded in sit¹.
Patent GB-189902550-A (GB)
Title: Improvements in Spring Buffers for Ships' Steering Gear.
Inventor: LOVERIDGE THOMAS
Filed: 1899-02-04
Granted: 1899-10-14
Abstract: 2550. Loveridge, T. Feb. 4. Steering-gear.-Relates to the spring buffers of steering-chains, and consists in placing the springs in casings containing oil, to protect them from corrosion. In the arrangement shown, the casing consists of a tube A closed at the ends by grooved plates secured by bolts B, B. The tube is filled through a plug-hole H.
Patent GB-189905529-A (GB)
Title: An Improved Process of Tanning.
Inventor: WARTENBERGER FRANZ WALTHER
Filed: 1899-03-14
Granted: 1899-12-16
Abstract: 5529. Wartenberger, F. W. March 14. Tanning.-Hides and skins are tanned after depilating and bating in the usual manner by immersion for a few hours in a weak solution of picric acid, and are subsequently rinsed in a solution of sodium hyposulphite. They are then washed and curried in the usual manner.
Patent GB-189906275-A (GB)
Title: Improvements in Metal Connecting Staples for and in the Method of Manufacturing Sun Blinds for Conservatories and Glass Houses, such Blinds being applicable also for Domestic and other purposes.
Inventor: ASHWORTH ELIJAH
Filed: 1899-03-23
Granted: 1900-02-03
Abstract: 6275. Ashworth, E. March 23. Staples.-Relates to making sun blinds for conservatories &c. The laths c are connected by staples a of copper &c. strip or wire united by copper rings b. The legs of the staples are passed through the holes c<1> in the laths and bent back as shown. The holes may be protected by washers or eyelets.
Patent GB-189908222-A (GB)
Title: Improvements in or relating to the Treatment of Sugar Molasses or Syrup by Means of Lime.
Inventor: ZAHN MAX BERNHARDT
Filed: 1899-04-19
Granted: 1899-06-17
Abstract: 8222. Zahn, M. B. April 19. Purifying saccharine liquids and syrups. - Molasses or syrups are treated with lime which is introduced in a powdered state from a rotary sieve D, provided with beaters G, and mounted within a casing E. A suitable cooling-apparatus A communic a t e s with the receptacle B, for the molasses or syrup, which is stirred by an agitator C.
Patent GB-189909791-A (GB)
Title: Improvements in Apparatus for receiving "Hertz" Electric Undulations or Waves.
Inventor: DUCRETET EUGENE
Filed: 1899-05-09
Granted: 1899-10-07
Abstract: 9791. Ducretet, E. May 9. Wireless telegraphy.-A coherer for Hertzian wave telegraphy is formed of an insulating-tube T capped at each end and having close-fitting metal rods P<1>, P<111>, one or both of which may be adjustable. The ends of the rods are formed of non-oxidizable or amalgamated metal, and the space between contains metal filings. A fixed central rod with two end rods forms two granule cells in a modified form. The coherer may be arranged in the relay or receiver circuit with variable condensers and with single-pole or other induction coils.