Patent SG-11202000312U-A (SG)
Title: Encapsulated polynucleotides and methods of use
Inventor: FINER MITCHELL H
IPC: C12N15/113
Filed: 2018-07-13
Abstract: RMACapsid f;yrometry , ,t433e Payx.c .frn; .. BO ---240 16-20 2:2-27 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) HIE Ho IIIII liolomo oimIE (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/014623 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT Hampshire Street, Suite 401, Cambridge, Massachusetts 02139 (US). LERNER, Lorena; c/o Oncorus, Inc., 50 Hampshire Street, Suite 401, Cambridge, Massachusetts 02139 (US). (74) Agent: WHITTLE, James R. et al.; Cooley LLP, 1299 Pennsylvania Avenue, N.W., Suite 700, Washington, Dis- trict of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (51) International Patent Classification: C12N 15/86 (2006.01) Cl 2N 9/12 (2006.01) C12N 15/85 (2006.01) Cl 2N 15/113 (2010.01) C12N 15/63 (2006.01) (21) International Application Number: PCT/US2018/042136 (22) International Filing Date: 13 July 2018 (13.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/532,886 14 July 2017 (14.07.2017) US 62/648,651 27 March 2018 (27.03.2018) US (71) Applicant: ONCORUS, INC. [US/US]; 50 Hampshire Street, Suite 401, Cambridge, Massachusetts 02139 (US). (72) Inventors: FINER, Mitchell H.; c/o Oncorus, Inc., 50 Hampshire Street, Suite 401, Cambridge, Massachusetts 02139 (US). KENNEDY, Edward; c/o Oncorus, Inc., 50 (54) Title: ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE Fig. 1 (57) : The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle. The present disclosure further relates to the encapsulation of the polynucleotides and the use of the polynucleotides and/or particles for the treatment and prevention of cancer. [Continued on next page] WO 2019/014623 Al 1110111111111111Hillinit111111111111111111filliIHIMMINIIIIIIIIIII GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))