baber/WOPTO huggingface dataset:
Patent EP-1737339-B1 (EP)
Title: Non-invasive system to monitor microcirculation
Inventor: NILSSON GERT
IPC: G01N/
Filed: 2005-04-18
Granted: 2009-01-07
Abstract: This invention relates to the non-invasive determination of the degree of vasoactivity in the microcirculation in a tissue caused by a drug, disease, injury normal or pathological regulation. More specifically, the invention relates to a method of determining the influence on microcirculation in living tissue from an irritative agent, drugs, disease, injuries normal or pathological regulation including, illuminating a tissue surface with polarized light, collecting the backscattered light through a polarizing filter, detecting the backscattered and polarized light by a photo-sensitive array, transferring the collected information in digital form to a computing device, separating the collected information into at least two data matrixes, each representing a specific wavelength range and generating an output data matrix by processing corresponding values in at least two data matrixes by an algorithm, wherein each value in said output data matrix represents the amount of influence on the microcirculation in a source point of the tissue. Thereby a representation of the tissue microcirculation is obtained.
Patent EP-1761174-B1 (EP)
Inventor: DIETZ TIMOTHY G
IPC: A61B10/02
Filed: 2005-05-20
Granted: 2009-10-07
Abstract: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and in particular a sleeve, to a biopsy site of suspicious tissues or lesions. A depth stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
Patent EP-1766461-B1 (EP)
Inventor: COLES HARRY J
IPC: G02F1/137
Filed: 2005-07-04
Granted: 2008-09-17
Abstract: A device for controlling the polarization state of transmitted light comprises first and second cell walls enclosing a layer of a chiral liquid crystal material. The material has a uniformly orientated helical axis in the absence of an applied field, and electrodes for applying an electric field substantially normal to the helical axis. An applied electric field flexoelectrically couples to the molecules, causing distortion of the helical structure and hence changes the bulk birefringence of the cell.
Patent EP-1781646-B1 (EP)
Inventor: KWAK BYONG SUNG
IPC: C07D281/16
Filed: 2005-06-17
Granted: 2010-08-18
Abstract: L'invention concerne un procédé de préparation de 11-(4-[2-(2-hydroxyéthoxy)éthyl]-1- pipérazinyl)-dibenzo[b,f][l,4]thiazépine. Lors de ce procédé, on soumet l'acide 2,2'-dithiosalicylique, en tant que matériau d'amorçage peu coûteux, à une réaction de formation de liaison avec 1-chloro-2- 5 nitrobenzène dans une solution aqueuse de base, on effectue une réaction de réduction par groupe nitro, des réactions de cyclisation et de chloration simultanément en présence d'une quantité équivalente d'un agent d'halogénation, une réaction avec pipérazine en continu sans séparation, et une réaction avec 2-haloéthoxyéthanol, ce qui permet de produire de manière économique et respectueuse de l'environnement de la quétiapine, à savoir, 11-(4-[2-(2-hydroxyéthoxy)éthyl]-l- pipérazinyl)-dibenzo[b,f][l,4]thiazépine. Plus précisément, Le procédé est intéressant car l'efficacité économique est assurée du fait que le matériau d'amorçage utilisé est peu coûteux, que l'utilisation d'un solvant organique est minimisée car la réaction est effectuée dans une solution aqueuse, et, en outre, on peut réaliser ce procédé respectueux de l'environnement et économique de par son intérêt commercial élevé, car le nombre de stades de réaction est réduit et la production de déchets acides est minimisée.
Patent EP-1774909-B1 (EP)
Inventor: FUKUI YASUHIRO
IPC: A61B19/00
Filed: 2005-07-20
Granted: 2011-03-16
Abstract: 本発明の断層像撮影装置は、被検者の体軸方向の複数の断層位置における断層像を同時に取得する撮影手段と、前記取得された複数の断層像を表示する表示手段と、前記複数の断層像それぞれの断層位置の相対的な距離を求める断層像間相対距離算出部と、前記求められた断層像間相対距離と前記複数の断層像を前記表示手段に表示制御する制御手段とを備える。これにより、処置者は表示された断層像間相対距離のデータと処置用具の長さを直感的に把握できるため、被検者等に対し処置用具の挿入位置の位置決めが効率的に行える。
Patent EP-1758578-B1 (EP)
Inventor: KERNS JEFFREY K
IPC: C07D401/04
Filed: 2005-06-24
Granted: 2010-12-29
Abstract: L'invention concerne de nouveaux dérivés d'indazole carboxamide. L'invention concerne plus précisément des composés représentés par la formule générale (I). Dans cette formule générale (I), R1 et Z désignent des éléments décrits ci-dessous. L'invention concerne également des sels de qualité pharmaceutique de ces dérivés. Les composés de l'invention sont des inhibiteurs d'IKK2 et peuvent être utilisés dans le traitement de troubles associés à une activité d'IKK2 (ou bêta IKK), tels que la polyarthrite rhumatoïde, l'asthme et la maladie pulmonaire obstructive chronique (MPOC). Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé de l'invention. L'invention concerne également des méthodes permettant d'inhiber l'activité d'IKK2 et de traiter des troubles associés, consistant à utiliser un composé de l'invention ou une composition pharmaceutique comprenant un composé de l'invention.
Patent EP-1819235-B1 (EP)
Inventor: WUEEST URS
IPC: A23K1/00
Filed: 2005-10-24
Granted: 2010-05-05
Abstract: A method for producing feedstuff, in particular pelletized feedstuff for chicken and pigs includes thermally holding pellets at a pellet press output and in post-conditioning said pellets in a rear container ( 6 ). Afterwards, the pellets come from the rear container ( 6 ) to a mixer ( 7 ), wherein liquids can be added without cooling. Drying and cooling are carried out afterwards, the pellets being transferred to a crumbler.
Patent EP-1812004-B1 (EP)
Inventor: BERDINI VALERIO
IPC: C07D473/34
Filed: 2005-10-25
Granted: 2011-06-22
Abstract: L'invention concerne un composé utilisé comme inhibiteur de la protéine kinase B, ledit composé étant de formule (I) ou l'un de ses sels, solvates, tautomères ou N-oxydes. Dans (I), T est N ou CR5 ; Jl-J2 est N=C(R6), (R7)C=N, (R8)N-C(O), (R8)2C-C(O), N=N ou (R7)C=C(R6) ; E est un groupe carbocyclique ou hétérocyclique monocyclique à 5 ou 6 éléments de cycle, le groupe hétérocyclique contenant jusqu'à 3 hétéroatomes sélectionnés parmi O, N et S ; Q1 est une liaison ou un groupe de liaison hydrocarboné saturé en C1-3, l'un des atomes de carbone dudit groupe de liaison pouvant facultativement être remplacé par un atome d'oxygène ou d'azote, ou bien une paire d'atomes de carbone adjacents pouvant être remplacés par CONRq ou NRqCO, où Rq est l'hydrogène ou le méthyle, ou Rq est une chaîne alkylène en C1-4 liée à R1 ou à un atome de carbone de Q1 et forme ainsi un fragment cyclique. Les atomes de carbone du groupe de liaison Q1 peuvent éventuellement porter un ou plusieurs substituants choisis parmi le fluor ou le groupe hydroxy. Q2 est une liaison ou un groupe de liaison hydrocarboné saturé contenant de 1 à 3 atomes de carbone, dans lequel l'un des carbones du groupe de liaison peut facultativement être remplacé par un atome d'oxygène ou d'azote ; les atomes de carbone du groupe de liaison peuvent éventuellement porter un ou plusieurs substituants fluor ou hydroxy, à condition que le groupe hydroxy, le cas échéant, ne soit pas situé sur un atome de carbone a immédiatement adjacent au groupe G ; et à l'autre condition que lorsque E est un aryle ou un hétéroaryle, Q2 soit autre qu'une liaison ; G est l'hydrogène, NR2R3, OH ou SH à condition que lorsque E est un aryle ou un hétéroaryle et Q2 une liaison, G soit l'hydrogène ; R1 est l'hydrogène ou un groupe aryle ou hétéroaryle, à condition que lorsque R1 est l'hydrogène et G est NR2R3, Q2 soit une liaison. Enfin, R2, R3, R4, R6 et R8 sont tels que définis dans les revendications.
Patent EP-1807065-B1 (EP)
Inventor: KISHORE BELLAMKONDA K
IPC: A61K31/10
Filed: 2005-10-21
Granted: 2012-03-28
Abstract: Disclosed are compositions and methods for treating nephrogenic diabetes insipidus and for induction of diuretic effect.
Patent EP-1830926-B1 (EP)
Inventor: WORRELL CORTNEY L
IPC: A61Q11/00
Filed: 2005-12-21
Granted: 2012-07-04
Abstract: L'invention concerne une composition buccale à effets bénéfiques multiples. Cette composition buccale est efficace en tant que composition buccale antibactérienne, antitartre, anti-inflammatoire, antioxydante et antihalitose. L'ingrédient actif possède au moins un composé actif provenant d'un extrait d'origan. Ladite composition buccale peut se présenter sous forme de rinçage de bouche, de dentifrice, y compris, de pâte dentifrice, de gels, de poudres, de produits animaliers, de film ou de friandises, tels que des losanges et similaires. Cette invention a aussi pour objet des méthodes de fabrication et d'utilisation de la composition buccale.
Patent EP-1681446-B1 (EP)
Inventor: MUTER JOHN P
IPC: F01N3/28
Filed: 2006-01-18
Granted: 2011-03-23
Abstract: An arrangement is provided for sealing a catalyst substrate (50) in a catalytic converter housing (22) wherein the housing has sidewalls defining a catalyst chamber (30), an inlet opening (26) upstream of the catalyst chamber (30) and an outlet opening (28) downstream of the catalyst chamber (30). The inlet and outlet openings (26,28) provide a fluid flow path through the housing (22) which further has a lateral access port (40) for installation and removal of a catalyst substrate (50) in the catalyst chamber (30) without axial separation of the catalyst chamber (30). A peripheral mantle (54) is provided about the substrate (50). The peripheral mantle (54) has first and second spaced-apart inwardly extending walls to either side of the substrate (50). The housing (22) has an inwardly facing sealing surface facing one of the inwardly extending walls. Locating means are provided which are securable to the housing (22) and which have positioning means extending therefrom which engage the peripheral mantle (54) to hold the peripheral mantle (54) and in turn the first wall enclosed juxtaposition with the outwardly facing sealing surface thereby defining a labyrinth seal (80) therebetween. The labyrinth seal (80) extends in a direction transverse to the fluid flow path and restricts fluid leakage between the catalyst and the housing (22). The locating means are provided with deflecting means for avoiding unwanted force input by the locating means to either the peripheral mantle (54) or the housing (22).
Patent EP-1755154-B1 (EP)
Inventor: MATSUMOTO TAKASHI
IPC: C23C14/08
Filed: 2006-03-17
Granted: 2011-02-16
Abstract: The present invention provides a method and apparatus for forming a zinc oxide thin film with high transparency and high conductivity on a surface of a flexible substrate such as plastic without the indispensable requirement of doping impurities. In the method of forming a zinc oxide thin film by reacting oxygen radicals and zinc atoms on a surface of a substrate placed in a film-forming chamber evacuated to a vacuum, the density of crystal defects that are defects of the atomic arrangement of the zinc oxide thin film is controlled by the temperature of the substrate, and the zinc oxide thin film is thereby formed. It is suitable to form the film while maintaining the temperature of the substrate at 400°C or less to intentionally disturb the regularity of the atomic arrangement of the zinc oxide thin film.
Patent EP-1728864-B1 (EP)
Inventor: SIADAK ANTHONY W
IPC: A61K47/48
Filed: 1996-01-26
Granted: 2012-08-01
Abstract: The present invention provides monoclonal antibodies, antigen binding fragment and recombinant binding proteins specific for human gp39. These antibodies are specific for at least 12 different epitopes on gp39. Hybridomas secreting specific antibodies which bind to these epitopes are also provided. Further, the present invention discloses the amino acid sequence of immunoglobulin light and heavy chain variable regions which bind to epitopes of gp39 and provide sFv and humanized antibodies which bind gp39. Also, provided are pharmaceutical compositions comprising the monoclonal antibodies, antigen binding fragments and recombinant binding proteins which bind gp39 and methods for using these compositions in diagnosing disease states, inhibiting B cell activation and for treating immunological disorders, such as autoimmune diseases, allergic responses, organ rejection and graft-versus-host disease. Antibodies of the present invention can also be used to image cells which express gp39 on their surface, such as tumor cells (e.g., lymphoma) and to target therapeutic agents to target cells.
Patent EP-1814079-B1 (EP)
Inventor: REICHENBACH JUERGEN
IPC: G06T5/40
Filed: 2006-12-12
Granted: 2011-06-08
Abstract: The method involves carrying out an adjustment on a pixel defined by a line and a space coordinate as well as by an intensity value. The two intensity corrections of the pixel, which can be accomplished at the same time, are independent from each other. The intensity corrections used are dependent on the line and space coordinates of individual pixels. An independent claim is also included for an opto-electronic sensor with a sensor matrix, an incident lens and an adjustment device for adjusting brightness of a raw image generated by a sensor matrix.
Patent EP-1844255-B1 (EP)
Title: Joint filete pour tuyaux en acier
Inventor: IMAI RYUICHI
IPC: F16B33/06
Filed: 2006-01-11
Granted: 2009-12-30
Abstract: La présente invention concerne un joint fileté pour des tuyaux en acier, comprenant une tige (1) et une boîte (2) qui présentent chacun une partie filetée (3a ou 3b) et une partie de contact métal-métal non filetée (4a ou 4b) en tant que surfaces de contact qui viennent en contact lorsque le joint est fixé. Ces surfaces de contact (3a et 4a et/ou 3b et 4b) de la tige (1) et/ou de la boîte (2) sont revêtues d'une couche inférieure d'un revêtement de lubrifiant solide qui contient une poudre de lubrifiant solide (par ex. du disulfure de molybdène, de disulfure de tungstène ou du graphite) et un liant (par ex. une résine époxy ou une autre résine organique), ainsi que d'une couche supérieure d'un revêtement anticorrosion solide qui est constitué d'une résine organique ne contenant pas de particule solide.
Patent EP-1841752-B1 (EP)
Inventor: SOKOLOFF PIERRE
IPC: C07D295/13
Filed: 2006-01-20
Granted: 2008-12-10
Abstract: The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders.
Patent EP-1975906-B1 (EP)
Inventor: FURUKAWA KAZUYOSHI
IPC: G06F7/72
Filed: 2006-01-13
Granted: 2012-07-04
Abstract: モンゴメリのアルゴリズムＲＥＤＣによって、ｒ進数のＡとＢについて、ＲＥＤＣ（Ａ×Ｂ）を計算する。プロセッサには、３入力２出力の積和回路が設けられているものを用いる。ＲＥＤＣをｒ進数の１桁ずつの演算に分解した場合の、Ａ×Ｂにあたる部分を、３入力２出力の積和回路に行わせる。積和回路には、ｒ進数で表されたＡの１桁ａｉと、Ｂの１桁ｂｊと、キャリー値ｃ１とを入力し、ａｉ×ｂｊ＋ｃ１を計算させ、結果のｒ進数２桁の上位桁をキャリー値ｃ１とし、下位桁を後の計算に使用する。また、積和回路には、ＲＥＤＣのための法Ｎの１桁ｎｉと、所定の値ｍと、キャリー値ｃ２を入力し、ｍ×ｎｉ＋ｃ２を計算させ、上位桁をキャリー値ｃ２とし、下位桁を後の計算に用いる。アルゴリズムが３入力２出力の積和計算で構成されているので、積和回路を有効利用して高速に処理できると共に、積和回路が２つ設けられている場合には、更に、演算を高速化できる。
Patent EP-1869216-B1 (EP)
Inventor: BAUSCH NIKO
IPC: G16B25/10
Filed: 2006-04-13
Granted: 2012-08-15
Abstract: The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.
Patent EP-1875268-B1 (EP)
Inventor: SAPE PHILIPPE
IPC: G01S5/04
Filed: 2006-04-26
Granted: 2011-10-05
Abstract: The device uses two has carriers (10, 11), e.g. military aircraft, each comprising a radar antenna, an electronic warfare receiver and a link transmitting information about angular position of a target (12) from the antenna to the receiver. Another link (40) provided between the receivers permits the exchange of direction information of the target between the carriers in order to permit one receiver to effectuate a triangulation calculation for determining the position of the target with respect to the carrier whose receiver effectuates the calculation. An independent claim is also included for a method for passive localization of target.
Patent EP-1924387-B1 (EP)
Inventor: REICHMANN RICHARD
IPC: G21B3/00
Filed: 2006-08-09
Granted: 2011-08-17
Abstract: The invention relates to a method for producing thermal energy, wherein, by means of a plasma arc which is located between a cathode and an anode, light initial material that is suitable for fusion processes is put into the plasma state by supplying electric energy. Use is made of a cathode made of a metal that is suitable for allowing the particles which are produced in the plasma to be diffused and for allowing a fusion process to take place in the metal grid. The invention has a high degree of efficiency in corresponding systems such that said methods can be used anywhere where fossil and/or renewable and/or chemical fuels are used, in order to use the thermal energy directly or by conversion.
Patent EP-1899325-B1 (EP)
Inventor: TEN HOLTE PETER
IPC: A61P35/00
Filed: 2006-06-20
Granted: 2011-11-16
Abstract: This invention comprises the novel compounds of Formula (I) wherein R1, R2, R3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Patent EP-1904728-B1 (EP)
Inventor: JENSEN JENS DAHL
IPC: B01J23/46
Filed: 2006-07-11
Granted: 2008-11-05
Abstract: A catalyst system for an internal combustion engine with at least one cylinder and/or piston is characterized in that the catalyst is arranged in the form of nanoparticles on the cylinder and/or piston.
Patent EP-1925963-B1 (EP)
Inventor: KINOSHITA TAKESHI
IPC: G02B3/14
Filed: 2006-08-23
Granted: 2012-02-29
Abstract: 構造が簡単で小型化に対応可能な焦点距離可変レンズと、これを利用した焦点距離調節装置及び撮像装置が提供される。
　焦点距離可変レンズ（１０）は、レンズ（１１）、正電極（１３）、負電極（１４）を備える。レンズ（１１）を構成する第２の層（１１ｂ）と第１の層（１１ａ）は、可塑剤が混入されたポリ塩化ビニルから形成され、可塑剤の混入量や種類等を調節することによりその硬さが調節されている。第２の層（１１ｂ）は第１の層（１１ａ）の少なくとも光の透過する領域を覆うように形成される。正電極（１３）と負電極（１４）の間に電圧が印加されると、第２の層（１１ｂ）と第１の層（１１ａ）は正電極（１３）に引かれるように変形し、それにより焦点距離可変レンズ（１０）の曲率が変化し、焦点距離が変化する。
Patent EP-1933671-B1 (EP)
Inventor: BENGTSSON ULF
IPC: A47C19/00
Filed: 2006-10-11
Granted: 2009-12-30
Abstract: A bunk (10) in a cab of a truck comprises a profile and a bottom. The profile is substantially L-shaped and has a base member (12) for supporting the bottom. The base member (12) has tongues (23) with punctured holes (24), which are arranged in parallel along the base member (12) and are spaced apart by equal intervals. The bottom can be a net (11) that is arranged over the tongues (23) before bending them over the base member (12). The bottom can alternatively be a board (40) or be a set of transversal ribs (50) or a set of extruded rubber rods (60) that is arranged over the tongues (23) and are fastened to the base member (12) by fastening means (41, 52, 62) through the holes (24).
Patent EP-1940659-B1 (EP)
Inventor: ZIMMER JOACHIM
IPC: B60S1/20
Filed: 2006-10-10
Granted: 2012-02-08
Abstract: L'invention concerne un ensemble essuie-glace, dans lequel, grâce à une commande, la trajectoire d'essuyage de forme sinusoïdale de la vitesse d'essuyage peut être réalisée, l'objectif de l'invention étant d'améliorer le fonctionnement. A cet effet, la trajectoire d'essuyage v(t) pour l'essuyage côté conducteur est utilisé, de sorte que ses maxima soient proches de la position de renversement inférieure et supérieure, de sorte que l'essuie-glace balaie, à une vitesse d'essuyage élevée et constante, un segment supérieur (1) du champ de balayage plus doucement et qu'il balaie le reste du champ de balayage (2) plus vite qu'une trajectoire symétrique par rapport à la position de renversement.
Patent EP-1960256-B1 (EP)
Inventor: VAN DER VELDE WILLEM JACOB
IPC: B63B35/44
Filed: 2006-12-14
Granted: 2009-05-20
Abstract: Vessel including a hull of a substantially closed surface has at deck level a lifting crane, ballast tanks within the hull and a ballast control unit for admitting water to the ballast tanks for changing the draft of the vessel. The hull has a narrow lower section having first width over a height from keel level to a widening level, and a top section having a larger width than the lower section, extending from the widening level upwards towards deck level. The control unit is adapted to ballast the vessel to have a relatively shallow draft level in a transit mode, so that the wide top section is above water level, while the vessel is traveling, and to ballast the vessel to a relatively deep draft level in a lifting mode so that the widening level is below water level, at least when the vessel is substantially stationary and the crane is in its lifting position.
Patent EP-1963337-B1 (EP)
Inventor: NOGRADI KATALIN
IPC: A61P25/00
Filed: 2006-12-19
Granted: 2010-09-01
Abstract: The present invention relates to new mGluR1 and mGluR5 receptor subtype preferring ligands of formula (I) wherein X represents a group selected from SO, SO2; Y represents a group selected from (CH2)n, NH, NHCH2; n is an integer of 0 to 1; Z is H or monosubstituted by alkyl, nitro, halogen, alkoxy, trifluoromethyl, cyano, amino, alkylamino, dialkylamino, aminomethyl, e alkylaminomethyl, dialkylaminomethyl, hydroxyl, alkylsulfonylamino; R1 is an optionally substituted alkyl, cycloalkyl, phenyl, biphenyl, heterocyclyl; R2 is an optionally substituted phenyl, heterocyclyl, or NR3R4 group wherein R3 and R4 are independently selected from the group of hydrogen and an optionally substituted alkyl, or R3 and R4 together with the N atom to which they are attached form an optionally substituted C5-7 heterocyclyl group, containing one or more heteroatom(s), or NH-CO-NR5R6 group, wherein R5 and R6 are independently selected from the group of hydrogen and an optionally substituted alkyl, or R5 and R6 together with the N atom to which they are attached form an optionally substituted C5-7 heterocyclyl group, containing one or more heteroatom(s); and/or hydrates and/or solvates and/or pharmaceutically acceptable salts thereof formed with acids or bases, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of pathological conditions which require the modulation of mGluR1 and mGluR5 receptors such as neurological disorders, psychiatric disorders, acute and chronic pain, neuromuscular dysfunctions of the lower urinary tract and gastrointestinal disorders.
Patent EP-1829503-B1 (EP)
Inventor: MICHELSON GARY KARLIN
IPC: A61F2/30
Filed: 1996-06-06
Granted: 2009-09-16
Abstract: An interbody spinal fusion implant (100) for insertion across the height of a disc space between two adjacent vertebral bodies of a human spine comprises a flat upper and lower surface (112,114), which form a support structure for bearing against the adjacent vertebral bodies. Each surface has at least one opening therethrough, wherein the openings are in communication with one another to permit for the growth of bone from adjacent vertebral body to adjacent vertebral body through said implant. The upper and lower surfaces each have an interior surface spaced apart from one another to define a hollow interior in communication with said openings. The implant includes an access opening (132) between said upper and lower surfaces and an access door (134). The access door permits the introduction of bone growth promoting material into the hollow interior. The access door is configured to cooperatively engage said implant for retaining the bone growth promoting material within said implant.