baber/WOPTO huggingface dataset:
Patent WO-2019238934-A1 (WO)
Title: Use of the apolipoprotein m for the treatment and diagnosis of insulin resistance
Inventor: VIGUERIE NATHALIE
IPC: C12N15/63
Filed: 2019-06-14
Abstract: The inventors examined APOM mRNA level and secretion in AT from patients in 6 independent clinical trials and in vitro in hMADS adipocytes. APOM expression and secretion were measured during dietary interventions. The inventors show that APOM is expressed in human subcutaneous and visceral AT and is released into circulation from AT. APOM expression in AT is lower in obese compared to lean individuals and reduced in subjects with metabolic syndrome and type 2 diabetes. Regardless of fat depot, there is a positive relationship between AT APOM expression and systemic insulin sensitivity. Finally, the inventors show that overexpression of APOM in the AT reduces AT inflammation and improves local insulin sensitivity during high fat diet induced obesity. Thus, the present invention relates to the present invention relates to the use of the apolipoprotein M for the treatment and diagnosis of insulin resistance.
Patent WO-2019243391-A1 (WO)
Title: Hybridation d'oligonucléotides tout-lna
Inventor: BERGMANN FRANK
IPC: G01N33/68
Filed: 2019-06-19
Abstract: La présente invention concerne l'hybridation d'oligonucléotides à simple brin (ss-) qui sont entièrement constitués de monomères d'acide nucléique bloqué (LNA). La présente invention montre des expériences d'hybridation avec des paires de ss-oligonucléotides entièrement complémentaires qui ne parviennent pas à former un duplex dans un intervalle de temps donné. La présente invention fournit des procédés pour identifier de telles paires d'oligonucléotides incompatibles. Dans un autre aspect, la présente invention fournit des paires de ss-oligonucléotides complémentaires qui sont capables de former un duplex rapide. La présente invention fournit également des procédés d'identification et de sélection de paires d'oligonucléotides compatibles. Selon encore un autre aspect, La présente invention fournit l'utilisation de paires d'oligonucléotides compatibles en tant que partenaires de liaison dans des dosages de liaison, par exemple des dosages immunologiques.
Patent WO-2020011589-A1 (WO)
Inventor: SHIN JUN SEOB
IPC: A61B8/08
Filed: 2019-07-02
Abstract: La présente invention concerne un système d'imagerie par ultrasons qui produit des images avec une résolution ou un contraste améliorés par extrapolation de deux images ultrasonores de différentes caractéristiques d'imagerie, telles que la taille d'ouverture, la fréquence d'imagerie ou le degré d'association d'images. Afin d'empêcher l'affichage d'artéfacts d'images, l'extrapolation est accompagnée par l'élimination d'artéfacts et un lissage d'image.
Patent WO-2020048675-A1 (WO)
Title: Betriebsverfahren und steuereinheit für ein daten-/signalauswertungssystem, date-/signalauswertungssystem, ultraschallbetriebsassistenzsystem und arbeitsvorrichtung
Inventor: WENZLER AXEL
IPC: G01S7/527
Filed: 2019-07-23
Abstract: Die vorliegende Erfindung betrifft ein Betriebsverfahren für ein Daten-/ Signalauswertesystem (1), insbesondere bei einem Ultraschallbetriebsassistenzsystem, bei welchem zur Auswertung von Daten und/oder Signalen eine Mehrzahl digitaler Signalverarbeitungsprozessoren (11, 12) in einer sequentiellen Pipeline (10) ausgebildet ist, mit einem ersten Betriebsmodus zur Bearbeitung von Aufgaben vergleichsweise höheren Rechenaufwands mit einem vergleichsweise höheren Maß an von den digitalen Signalverarbeitungsprozessoren (11, 12) aufzubringender Rechenleistung und mit einem zweiten Betriebsmodus zur Bearbeitung von Aufgaben vergleichsweise geringeren Rechenaufwands mit einem vergleichsweise geringeren Maß an von den digitalen Signalverarbeitungsprozessoren (11, 12) aufzubringender Rechenleistung, wobei im ersten Betriebsmodus digitale Signalverarbeitungsprozessoren (11, 12) der sequentiellen Pipeline (10) zeitlich parallel betrieben werden und im zweiten Betriebsmodus zumindest ein Paar (15) der Mehrzahl digitaler Signalverarbeitungsprozessoren (11, 12) der sequentiellen Pipeline (10) zeitlich sequentiell betrieben werden.
Patent WO-2020025649-A1 (WO)
Title: Pseudo-random permutation generator
Inventor: BENJILALI WISSAM
IPC: G09C1/00
Filed: 2019-07-31
Abstract: The present description relates to a method for generating a sequence of pseudo-random numerical codes which make it possible to carry out a permutation (3) of a first set of values (V) into a second set of values (Vp) on the basis of said numerical codes (CPos), which represent positions (j) of values (Vi) of the first set in the second set, comprising the following steps: generating, by successive iterations, a chain of numbers, referred to as seed numbers, from an initial pseudo-random seed number (W0) by applying a first function (24, 26) of a seed number to the following seed number; applying a second function to each grain number of the chain in order to obtain each position code (CPos(j)), the second function comprising at least one permutation (PERM) followed by a bijective function (BIJ).
Patent WO-2020038864-A1 (WO)
Title: Vorrichtung zur herstellung von gegenständen durch schichtweises aufbauen aus pulverförmigem werkstoff
Inventor: FOCKELE MATTHIAS
IPC: B33Y40/00
Filed: 2019-08-19
Abstract: Die Erfindung betrifft eine Vorrichtung zur Herstellung von Gegenständen durch schichtweises Aufbauen aus Pulverwerkstoff. Sie umfasst ein Bauvolumengehäuse (16) mit einer Umfangswandung (18), eine Basisplattenanordnung (12), wobei die Umfangswandung (18) und die Basisplattenanordnung (12) relativ zueinander bewegbar sind, eine Pulverschichtenpräparationseinrichtung (10) zur Bildung einer jeweiligen Werkstoffpulverschicht (20) zur Aktualisierung eines Baufeldes (7), eine Bestrahlungseinrichtung (2) zur ortsselektiven Bestrahlung der jeweils zuletzt präparierten Werkstoffpulverschicht (20) zum Zwecke des ortsselektiv gezielten Umschmelzens des Pulvers und ein oberes Prozessraumgehäuse (4) zur Bildung eines abgedichteten Hohlraumes über dem Baufeld. Die Pulverschichtenpräparationsreinrichtung (10) und das Prozessraumgehäuse (4) sind Komponenten eines gemeinsamen Fertigungsmoduls (8), welches trennbar mit dem Bauvolumengehäuse (16) verbunden ist. Das Bauvolumengehäuse ist oberseitig verschließbar, so dass die Umfangswandung (18), die Basisplattenanordnung (12) und eine das Bauvolumengehäuse (16) oben abschließende Verschlusseinrichtung (26) das innere Volumen des Bauvolumengehäuses (16) abschließen, wobei das Bauvolumengehäuse (16) mit so geschlossenem Bauvolumen der Vorrichtung entnehmbar ist.
Patent WO-2020043617-A1 (WO)
Inventor: HAGEMANN URS
IPC: A61P35/00
Filed: 2019-08-23
Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being a targeted thorium conjugate. Another aspect of the present invention relates to the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particurlarly for the treatment of breast and prostate cancer.
Patent WO-2020070165-A1 (WO)
Inventor: BRODIE ALASTAIR JOHN
IPC: E21B17/00
Filed: 2019-10-01
Abstract: L'invention concerne un dispositif de protection (1) pour une partie d'extrémité mâle (20) d'un tube en acier (10) destiné à être utilisé dans une chaîne de travail d'hydrocarbures tubulaire, le dispositif (1) comprenant un corps de manchon cylindrique (2) ayant un axe principal (X) et délimitant une cavité interne (5) destinée à recevoir la partie d'extrémité mâle (20), une partie de mise en prise (3) caractérisée en ce que le corps de manchon cylindrique (2) est fendu axialement en au moins deux coques (7, 8) maintenues ensemble par une jonction (4) et en ce que la partie de mise en prise (3) est configurée pour séparer lesdites deux coques (7, 8) sous l'effet d'une force axiale prédéfinie sur une première ou une seconde surface de mise en prise (9b, 9h).
Patent WO-2020079033-A1 (WO)
Title: Genome editing methods and constructs
Inventor: AURICCHIO ALBERTO
IPC: C12N15/10
Filed: 2019-10-15
Abstract: The present invention relates to a method of integrating an exogenous DNA sequence into a genome of a cell comprising contacting the cell with: a) a donor nucleic acid comprising: - at least one STOP codon and a translation initiation sequence (TIS) or - a ribosomal skipping sequence, and - said exogenous DNA sequence wherein said donor nucleic acid is flanked at 5' and 3' by inverted targeting sequences; b) a complementary strand oligonucleotide homologous to the targeting sequence and c) a nuclease that recognizes the targeting sequence.
Patent WO-2020089051-A1 (WO)
Title: Formulation d'anticorps
Inventor: FREICHEL CHRISTIAN
IPC: A61K39/395
Filed: 2019-10-25
Abstract: La présente invention concerne une formulation pharmaceutique d'un anticorps bispécifique anti-VEGF/ANG2 et un procédé de préparation ainsi que des utilisations de la formulation.
Patent WO-2021083505-A1 (WO)
Inventor: SHERMER CHARLES
IPC: A61F2/07
Filed: 2019-10-30
Abstract: The present invention relates to a TIPS stent graft, comprising a tubular component having a lumen extending therethrough, the tubular component comprising a balloon expandable central section and a first and a second self- expanding section, the first and the second self-expanding section sandwiching the central section, the lumen extending through the first, central, and second sections, the stent graft being capable of selectively constricting the central section.
Patent WO-2020089376-A1 (WO)
Inventor: ROBERTS JOHANNES
IPC: A61B90/00
Filed: 2019-10-31
Abstract: The present invention relates to user guiding during X-ray imaging. In order to provide further guidance during X-ray imaging, a guiding device (10) for visual guidance during X-ray imaging is provided. The guiding device (10) comprises a camera arrangement (12), a display arrangement (14) and a housing structure (16). The housing structure comprises a housing (18) of an X-ray imaging system for housing an X-ray source or an X- ray detector. Further, the camera arrangement is configured to capture image data of a region of interest of a subject in front of the housing. Furthermore, the display arrangement is configured to present the captured image data as a live presentation of the region of interest. Still further, the camera arrangement is mounted to the housing on a first side (20) of the housing, and the display arrangement is mounted to the housing on a second side (22) of the housing, the second side being at least one of the group of lateral and opposite to the first side. Hence, the display arrangement is configured to provide a presentation comprising live images from the first side to a user located on the second side of the housing.
Patent WO-2020099272-A1 (WO)
Title: A wireless communication node arranged to operate in a wireless network, as well as a related method, for synchronizing power bursts during transmission of a message
Inventor: WENDT MATTHIAS
IPC: H02M1/00
Filed: 2019-11-08
Abstract: The invention relates to a wireless communication node arranged to operate in a wireless network, wherein said wireless communication node is arranged for supplying power to an electrical load as well as arranged for wireless connectivity. The wireless communication node comprising a wireless communication unit for providing wireless connectivity, a switched mode power supply, arranged for supplying power to said electrical load and to said wireless communication unit, wherein said SMPS operates in accordance with a burst mode operation, wherein said SMPS is alternatively enabled and disabled and a controller arranged for ensuring that said SMPS is enabled when said wireless communication unit is to transmit a message.
Patent WO-2020164765-A1 (WO)
Inventor: REINERMANN ROBERT
IPC: G06Q10/10
Filed: 2019-11-12
Abstract: L'invention concerne un procédé pour l'évaluation automatique de sociétés d'installation d'installations d'extinction d'incendie, plusieurs critères pour la certification d'une entreprise d'installation étant fixés, une métrique d'évaluation étant définie côté système, au moyen de laquelle des informations pour remplir les critères sont évaluées automatiquement et au moyen de laquelle on détermine si des conditions pour une certification de l'entreprise d'installation sont remplies. L'invention concerne en outre un système correspondant pour l'évaluation automatique de sociétés d'installation d'installations d'extinction d'incendie.
Patent WO-2020104260-A1 (WO)
Title: Filtervorrichtung
Inventor: KLEIN VOLKMAR
IPC: B01D35/147
Filed: 2019-11-12
Abstract: Filtervorrichtung mit einem Filtergehäuse (2) und einem darin aufgenommenen Filterelement (15), dessen Elementmaterial (44) sich zur Filtrierung einer Flüssigkeit zwischen zwei Endkappen (40, 42) erstreckt, von denen zumindest eine Endkappe (40) an einer Elementaufnahme (14) gelagert ist, wobei mittels einer mehr als einen Freiheitsgrad zur Verfügung stellenden Lagerung (46, 54) das Filterelement (15) über seine eine Endkappe (40) gelenkig an der Elementaufnahme (14) gelagert ist, dadurch gekennzeichnet, dass die Lagerung eine konvex verlaufende Lagerfläche (46) aufweist, die in einer konkav verlaufenden Lagerfläche (54) geführt ist, und dass die jeweilige Lagerfläche (46, 54) Bestandteil einer Schale ist, von denen mindestens eine einen Durchlass für Flüssigkeit aufweist.
Patent WO-2020114876-A1 (WO)
Inventor: JESPERSEN UFFE
IPC: F24F13/02
Filed: 2019-11-28
Abstract: A building system comprising a building space defined by a structural ceiling (2) and a flooring (3) of a building, and a ceiling system (4). The ceiling system (4) comprises an air permeable suspended ceiling (5) arranged below the structural ceiling (2), wherein a plenum space (7) is formed between the suspended ceiling (5) and the structural ceiling (2) and a flooring space (8) is formed between the flooring (3) and the suspended ceiling (5), and a plurality of partition wall sections (6). The plurality of partition wall sections (6) is arranged in the plenum space (7) extending between the structural ceiling (2) and the suspended ceiling (5); and forms a plurality of plenum modules (9) distributed across the plenum space (7). Each one of the plurality of plenum modules (9) comprises equipment, the equipment of each plenum module (9) comprising a supply air device (12) for delivery of supply air to the associated plenum module (9) for pressurization thereof such that the supply air delivered to the plenum module (9) is supplied to the flooring space (8) through the air permeable suspended ceiling (5).
Patent WO-2020127954-A1 (WO)
Inventor: HANSEN JOHN BONDO
IPC: A61K31/496
Filed: 2019-12-20
Abstract: The present disclosure relates to optimised administration regimens of 5-HT1A agonists and levodopa in the management of movement disorders, such as Parkinson's disease and levodopa-induced dyskinesia (LID).
Patent WO-2020136190-A1 (WO)
Title: Elastomeric composition with coarse black
Inventor: COUE JEAN
IPC: C08K3/04
Filed: 2019-12-24
Abstract: The present invention relates to an elastomeric composition comprising a) an elastomeric matrix comprising at least 60 phr of at least one elastomer chosen from natural rubber and synthetic polyisoprenes, b) 10 to 30 phr of a carbon black having a BET specific surface area varying from 15 to 28 m 2 /g and a COAN index varying from 20 to 60 ml/g, c) at least 10 phr of at least one plasticizer, and d) a crosslinking system.
Patent WO-2020148240-A1 (WO)
Title: Support de véhicule et rangée de supports de véhicule
Inventor: HÄNGGI DANIEL
IPC: B62H3/00
Filed: 2020-01-13
Abstract: La présente invention concerne un support de véhicule et une rangée de supports de véhicule pour un véhicule à chenille unique doté d'un engrenage de direction, chaque support de véhicule étant doté d'un casier (6, 6a) d'utilisation pratique pour le conducteur ou d'un creux (2, 2a) destiné à guider une roue orientable le long de laquelle le rapport (HD/VD) entre sa distance horizontale (HD) et sa distance verticale (VD) change de sorte que le creux (2, 2a) permet ultérieurement un décentrage de direction.
Patent WO-2020164938-A1 (WO)
Inventor: KOERBER KARSTEN
IPC: A01N43/78
Filed: 2020-02-03
Abstract: The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests.
Patent WO-2020173955-A1 (WO)
Inventor: HANSEN ESBEN ROSENLUND
IPC: A61B5/00
Filed: 2020-02-25
Abstract: La présente invention concerne un système de balayage pour balayer un objet, comprenant : un dispositif de balayage comprenant : un capteur d'image pour acquérir des images; une interface de montage pour monter de manière amovible au moins l'un d'une pluralité de types de pointes de balayage, chacune de la pluralité de types de pointes de balayage étant configurée pour fournir de la lumière à l'objet dans un mode d'éclairage qui diffère pour chacun de la pluralité de types de pointes de balayage.
Patent WO-2020207683-A1 (WO)
Title: Converter arrangement with neutral point clamped choppers
Inventor: STEMMLER CHRISTOPH
IPC: H02M3/156
Filed: 2020-03-10
Abstract: A converter arrangement (30) comprises a first chopper circuit (40a) for connecting a positive input (32a) or a neutral point (50) with a positive output (34a), wherein the first chopper circuit (40a) comprises a first switch arrangement (42a), a first inductor (44a) and a first capacity (46a), wherein the first switch arrangement (42a) is adapted for connecting the first inductor (44a) with the positive input (32a) or with the neutral point (50), the first inductor (44a) interconnects the first switch arrangement (42a) with the positive output (34a) and the first capacity (46a) interconnects the positive output (34a) with the neutral point (50). The converter arrangement (30) further comprises a second chopper circuit (40b) for connecting a negative input (32b) or the neutral point (50) with a negative output (34b), wherein the second chopper circuit (40b) comprises a second switch arrangement (42b), a second inductor (44b) and a second capacity (46b), wherein the second switch arrangement (42b) is adapted for connecting the second inductor (44b) with the negative input (32b) or with the neutral point (50), the second inductor (44b) interconnects the second switch arrangement (42b) with the negative output (34b) and the second capacity (46b) interconnects the negative output (34b) with the neutral point (50). The converter arrangement (30) further comprises an overvoltage protection device (52) adapted for short- circuiting the positive output (34a) and the negative output (34b), when an overvoltage is measured between the positive output (34a) and/or the negative output (34b) and the neutral point (50, 54).
Patent WO-2020187848-A1 (WO)
Title: Lnterleukin-2 receptor (il2r) and interleukin-2 (il2) variants for specific activation of immune effector cells
Inventor: SAHIN UGUR
IPC: C07K14/55
Filed: 2020-03-16
Abstract: The invention relates to variants of the alpha subunit of interleukin-2 receptor (IL2R) and interleukin-2 (IL2). In one embodiment, the IL2 variants described herein have amino acid substitutions at the region of !L2 that contacts the alpha (α) subunit of the heterotrimeric IL2 receptor complex, IL2Rαβγ, reducing its ability to bind and activate the heterotrimeric receptor complex. Conversely, the corresponding IL2Rα variants described herein have amino acid substitutions compensating for such reduced ability of IL2 variants to bind to and activate IL2Rαβγ, preferably at amino acid residues contacted by IL2 amino acid residues that are substituted in the IL2 variants described herein.
Patent WO-2020208112-A1 (WO)
Title: Piece for guiding and locking an actuator and actuator comprising same
Inventor: JUBERT THIBAUT
IPC: F16F9/56
Filed: 2020-04-08
Abstract: Disclosed is a piece (10) for guiding and locking a predetermined gas and/or spring actuator comprising a piston (11) and a tube (12) comprising an axial recess (19) in which the piston can slide, which piece comprises, in a body (13): - a cavity (15) for receiving the tube configured to receive, in its interior, one end of the tube free to slide out of the cavity and - a cavity (16) for receiving the piston, coaxial with the cavity for the tube and in the continuation of the cavity for the tube, configured to receive, in its interior, the piston free to move in translation along the axis (21) common to the cavities; characterised in that it also comprises - on the side of the cavity for receiving the tube, relative to a plane (24) perpendicular to the axis (21) of the cavities and passing through the bottom of the cavity for receiving the tube, a protrusion (14) extending beyond the cavity for receiving the tube, configured to penetrate into the tube.
Patent WO-2021073778-A1 (WO)
Title: Compositions and methods for vaccinating piglets against streptococcus
Inventor: VOLKER FLORIAN
IPC: A61P31/04
Filed: 2020-04-09
Abstract: The present application relates to methods for treating infection by Streptococcus suis (S. suis) in mammals, particularly in pigs. The application more particularly relates to a prime-boost vaccination approach for treating (in a preventive or curative setting) infections by Streptococcus suis (and/or diseases caused by infection by Streptococcus suis) in mammals. The methods of the invention use an IgM protease of, or (derived) from, Streptococcus suis as an antigen to induce protective immunity in piglets.
Patent WO-2020212471-A1 (WO)
Inventor: ADAMO VINCENT
IPC: A61J1/14
Filed: 2020-04-16
Abstract: The invention relates to a medicinal product (10), in particular sterile medicinal product, comprising a flexible mono-chamber container (14) and an aqueous liquid (12) containing bicarbonate and having a physiological pH value, wherein the container (14) comprises a first side wall (15a) and a second side wall (15b), wherein the first side wall (15a) and the second side wall (15b) comprises a barrier material which is capable of preventing or retarding escape of carbon dioxide from the container (14) and/or intake of carbon dioxide into the container (14) such that the pH value of the aqueous liquid (12) is maintained or substantially maintained during a shelf life at room temperature of the medicinal product (10) for at least 12 months.
Patent WO-2020212511-A1 (WO)
Title: Kühlölleitelement sowie antriebsstrang mit diesem
Inventor: MATSCHAS STEFFEN
IPC: F16D25/12
Filed: 2020-04-16
Abstract: Die vorliegende Erfindung betrifft eine Kühlölleiteinrichtung für rotierende Bauteile, wobei ein ringförmiger Ölkanal (K) in radialer Richtung verläuft, und wobei Kühlöl von radial innen zuführbar ist und der Ölkanal (K) radial außen teilweise offen ist, dadurch gekennzeichnet, dass in einem radial äußeren Bereich des Ölkanals (K) ein Dichtbereich vorgesehen ist, dass der Dichtbereich Sperrelemente (12) und Austrittselemente (13) aufweist, dass die Sperrelemente (12) radial innerhalb der Austrittselemente (13) angeordnet sind und zumindest zwei über den Umfang verteilte Durchlässe (14) in radialer Richtung aufweisen, dass durch die Austrittselemente (13) mit den Durchlässen (14) fluchtenden Austrittskanäle (A) und in Umfangsrichtung zwischen den Austrittskanälen (A) gelegene Einlässe (E) gebildet sind, und dass ein Ringkanal (R) zwischen den Sperrelementen (12) und den Austrittselementen (13) vorgesehen ist, um die Einlässe (E) mit den Austrittskanälen (A) beziehungsweise Durchlässen (14) zu verbinden. Weiter betrifft die Erfindung einen Antriebsstrang mit einer derartigen Kühlölleiteinrichtung.
Patent WO-2020254654-A1 (WO)
Inventor: RYCKELYNCK MICHAËL
IPC: C07H21/02
Filed: 2020-06-19
Abstract: The invention relates to a molecular complex emitting fluorescent light comprising, or consisting essentially of: • - a fluorophore, and • - a nucleic acid molecule, wherein said fluorophore has of the following formula 3