Patent SG-11201903462U-A (SG)
Title: Methods of delivering a neuroprotective polypeptide to the central nervous system
Inventor: KIM DONG
IPC: A61K47/34
Filed: 2017-10-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111 011101010111110111110101111111111111011111011111011111110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/075901 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: Transfer, 6011 Executive Blvd. Suite 325, Rockville, MD A61K 38/26 (2006.01) A61K 9/16 (2006.01) 20852 (US). A61K 47/34 (2017.01) A61P 25/28 (2006.01) (72) Inventors: KIM, Dong, Seok; 10000 Town Center (21) International Application Number: Ave., Apt. 413, Columbia, MD 21044 (US). KIM, Hee, PCT/US2017/057606 Kyung; 108-706, 501, Expo-ro, Yuseong-gu, Daejeon (22) International Filing Date: (KR). GREIG, Nigel, H.; 11 Anne Brent Garth, Phoenix, MD 21131 (US). 20 October 2017 (20.10.2017) (25) Filing Language: English (74) Agent: ZERHUSEN, Bryan, D. et al.; Locke Lord LLP, P.O. Box 55874, Boston, MA 02205 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/410,748 20 October 2016 (20.10.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicants: PEPTRON, INC. [KR/KR]; 37-24, Yuseong- DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, daero, 1628 Beon-gil, Yuseong-gu, Daejeon, 305-811 (KR). HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, THE UNITED STATES OF AMERICA, as represented KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, by THE SECRETARY, DEPARTMENT OF HELATH MG, MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, & HUMAN SERVICES [US/US]; Office of Technology Title: METHODS OF DELIVERING A NEUROPROTECTIVE POLYPEPTIDE TO THE CENTRAL NERVOUS SYSTEM (54) = FIG. 1A = b.0 3 = R ,. a a = Li c o I-) a 2 1 x ,,, W 0 I -,-- = _ = _ _= — = = - _ 0 7 14 21 Time (day) = : The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central (57) _ nervous system (CNS) of a subject. The method includes administering to the systemic blood circulation of the subject a therapeutically 1-1 , 1 effective amount of a neuroprotective polypeptide by a controlled-release formulation or a device providing a sustained release of the neuroprotective polypeptide including at least one neuroprotective polypeptide selected from the group consisting of GLP-1, exendin-4, 11 or a therapeutically effective GLP-1 or exendin-4 analogue; the neuroprotective polypeptide binds to and activates a receptor that binds at CT least one of GLP-1, exendin-4, or a combination thereof; and the controlled-release neuroprotective formulation or the sustained in release of the neuroprotective polypeptide enhances the delivery of the neuroprotective polypeptide across a blood-brain barrier (BBB) IN of the subject to at least a portion of the CNS relative to a rapid release formulation of the neuroprotective polypeptide. Also disclosed 0 --.... is Ot in 11 a method of treating a subject with a CNS-related disease or reducing at least one symptom of a CNS-related disease in a subject need thereof. 0 ei O [Continued on next page] WO 2018/075901 Al MIDEDIMOMOIDEIREEMOMMIMOIMMENVOIMIE OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))