baber/WOPTO huggingface dataset:
Patent DE-69535260-D1 (DE)
Inventor: MOYLE WILLIAM R
IPC: A61K48/00
Filed: 1995-02-17
Granted: 2006-11-23
Abstract: The present invention relates to methods for enhancing fertility by reducing the activities and/or levels of circulating glycoprotein hormones having lutropin (LH) activity. The molecules of the invention are antibodies or other binding agents that reduce the biological activities of LH. The present invention also relates to novel methods for devising and/or selecting antibodies to specific portions of proteins including LH and human chorionic gonadotropin (hCG) to permit their biological activities to be reduced to desired degrees. The present invention also relates to the preparation of single subunit gonadotropins and gonadotropin antagonists for use in stimulating and inhibiting fertility and for controlling ovarian hyperstimulation. In a preferred embodiment, the present invention pertains to a method for stimulating fertility in mammals by reducing the activity of glycoprotein hormones having luteinizing hormone activity in circulation and thereby stimulating the production of follicle stimulating hormone which comprises administering to the mammal a therapeutically effective amount of a binding agent that binds luteinizing hormone.
Patent DE-69603176-D1 (DE)
Inventor: RIOSIER PASCAL
IPC: B65D81/34
Filed: 1996-04-19
Granted: 1999-08-12
Abstract: The present invention concerns a process for producing a reusable mechanical element, such as a connection element or a tool comprising at least one object. The process is characterized in that it consists in heating a product (5) of the polycaprolactone type to a temperature close to its softening temperature, manually bringing a given volume of this product into contact with at least part of the external surface of the object (12) and holding it there until it cools, resulting in at least partial stiffening of the product (5) on the object, such that it is rendered integral therewith.
Patent DE-69603974-D1 (DE)
Inventor: GUERIN GILLES
IPC: C09K23/02
Filed: 1996-10-23
Granted: 1999-09-30
Abstract: Water-redispersible granules including at least one active material in the form of a hydrophobic liquid, at least one ionic surfactant selected from at least partially salified alkylsulphonic acids, alkylarylsulphonic acids or mixtures thereof, and at least one water-soluble compound selected from sugars and derivatives thereof, are disclosed. A method for preparing such granules by preparing an aqueous emulsion of at least one active material, at least one ionic surfactant and at least one water-soluble compound, and drying the resulting emulsion, is also disclosed.
Patent DE-69610957-D1 (DE)
Inventor: DILL MICHAEL C
IPC: F16B25/10
Filed: 1996-08-19
Granted: 2000-12-21
Abstract: A screw (10) for use with a washer (16) as a sealing fastener having formations (28,30) near the head (22) of the screw (10) to increase driving resistance when the portion (28) having the formations (30) reaches a surface (12) into which the screw (10) is being driven. The screw (10) includes a shank (18) with a tip end and a head end. A head (22) at the head end may be driven by a driving tool such as a pneumatic or electric drill. To facilitate retention of the washer (16) the head (22) has a flange (32) that forms a recess (34). The shank (18) has an enlarged portion (28) near the head (22) adjacent to the recess (34) and the enlarged portion (28) has ridges (30). The enlarged portion (28), including the ridges (30), increases the driving resistance of the screw (10). This increase in resistance gives notice to an operator of the driving tool that an appropriate driving depth and torque have been achieved. Preferably, the washer (16) has an inner diameter surface (42) with fully radiused projections (44). The projections (44) assist in mounting the washer (16) to the screw (10) and keeping the washer (16) appropriately positioned on the screw (10) during storage and driving. <IMAGE>
Patent DE-69618766-D1 (DE)
Inventor: PAN Y
IPC: F15C3/04
Filed: 1996-02-26
Granted: 2002-03-14
Abstract: Embodiments described herein relate to methods and structures for controlling a valve. One embodiment provides a valve control comprising a first valve fluidly connected with a first fluid conveying conduit and a second fluid conveying conduit. The first valve is movable between a first position where fluid communicates between the first fluid conveying conduit and the second fluid conveying conduit and a second position where fluid does not communicate between the first fluid conveying conduit and the second fluid conveying conduit. A first source of relatively increased pressure and a first source of relatively reduced pressure are provided. A third conduit fluidly connects the first source of relatively increased pressure and the first source of relatively reduced pressure with the first valve. A third valve is fluidly connected with the third conduit. The third valve is movable between a first position where the first source of relatively increased pressure is fluidly connected with the third conduit and the first valve thereby moving the first valve toward its second position and a second position where the first source of relatively reduced pressure is fluidly connected with the third conduit and the first valve thereby moving the first valve toward its first position. A second valve is fluidly connected with the third conduit between the third valve and the first valve. The second valve is movable between a first position where fluid communicates between the first valve and the third valve and a second position where no fluid communicates between the first valve and the third valve.
Patent DE-69627169-D1 (DE)
Inventor: PRICE WALTER
IPC: E04H15/40
Filed: 1996-10-23
Granted: 2003-05-08
Abstract: The present invention is a fast-erecting tent in which several open-ended arcuate interconnect via a single connector. The frame of the tent includes 1) a pair of resilient, planar open-end arcuate sections that form a filiform base loop; 2) a pair of resilent open-end arcuate sections that form a filiform upper loop; 3) a connector which links a terminal end of the first arcuate section of the base loop plus a terminal end of the first arcuate section of the upper loop to the terminal end of the second arcuate section of the base loop plus the terminal end of the second arcuate section of the upper loop; and 4) a segmented, internally biased, arch shaped tubular strut. The ends of the strut are slidably and rotatably connected to the arcuate sections of the base loop. The strut is connected to the arcuate sections of the upper loop by means of a twist clip. The fabric covering is wrapped around and attached to the frame by conventional means. The connector is a sleeve with a through-bore. Through-bar having a cross-section of multiple, parallel, partial, interconnected, right circular cylinders and is designed so that the terminal ends of the arcuate sections forming the filiforms loops can be retained in the through-bore mainly by friction. The terminal ends of the arcuate sections that form the filiform loops are permanently fixed within the through-bore at a first end of the connector but are free to slide, rotate, and swivel in and be detached from a second end of the through-bore. Both the base loop and upper loop can be either elliptical or semi-elliptical.
Patent DE-69627304-D1 (DE)
Inventor: LASH RAY
IPC: B65D5/00
Filed: 1996-01-22
Granted: 2003-05-15
Abstract: The present invention provides a package containing absorbent articles having differing absorbent capacities. The package includes at least one first absorbent article packaged within the package and having a predetermined absorbent capacity, and at least one second absorbent article packaged within the package and having a predetermined absorbent capacity. The absorbent capacity of the second absorbent article is greater than the absorbent capacity of the first absorbent article.
Patent DE-69628556-D1 (DE)
Inventor: DOLL J
IPC: A61K31/445
Filed: 1996-04-03
Granted: 2003-07-10
Abstract: Novel compounds of Formula   <IMAGE>   are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
Patent DE-69629702-D1 (DE)
Inventor: LOVE GUY
IPC: C12N15/09
Filed: 1996-07-24
Granted: 2003-10-02
Abstract: PCT No. PCT/GB96/01775 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Jul. 24, 1996 PCT Pub. No. WO97/04787 PCT Pub. Date Feb. 13, 1997A pharmaceutical composition comprising (A) an oligonucleotide 8 to 50 nucleotides in length, which is targeted to mRNA encoding human raf and is capable of inhibiting raf expression, entrapped in (B) sterically stabilized liposomes.
Patent DE-69630234-D1 (DE)
Inventor: OGREID DAGFINN
IPC: C12Q1/6886
Filed: 1996-11-15
Granted: 2003-11-06
Abstract: Method for detecting Ki-ras mutations in exon I, codon 12 to 13 in samples of tissue, tumor tissue, tissue secretions, excretions, expectorates, blood and lymph using regular PCR amplification with allele specific primers or two subsequent PCR amplifications comprising regular PCR and allele specific PCR.
Patent DE-69634004-D1 (DE)
Inventor: SUGUMI HIROYUKI
IPC: C07D471/16
Filed: 1996-05-31
Granted: 2005-01-13
Abstract: Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: <CHEM> wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula -e-f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity.
Patent DE-69634563-D1 (DE)
Inventor: JUNE H
IPC: C12N15/87
Filed: 1996-05-02
Granted: 2005-05-12
Abstract: A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.
Patent DE-69634851-D1 (DE)
Inventor: KNIGHT L
IPC: C12N15/85
Filed: 1996-02-28
Granted: 2005-07-21
Abstract: Novel methods are provided for producing rabbit fusion partners for the production of specific binding proteins, particularly immunoglobulins. Nuclei of rabbit fertilized ova are microinjected with an oncogene to express specifically in lymphoid cells (i.e., lymphoid specific) and the embryos are then implanted in appropriate hosts. The newborns are maintained to sexual maturity and are either mated with rabbit hosts that developed from embryos that had been microinjected with a different lymphoid-specific oncogene or their fertilized eggs are microinjected with another oncogene specific for lymphoid cells. The immortalized lymphoid cells that develop in these animals may be genetically altered and used as fusion partners to produce rabbit hybridomas for the production of monoclonal antibodies.
Patent DE-69709334-D1 (DE)
Inventor: KORHONEN PERTTI
IPC: B65H75/10
Filed: 1997-03-10
Granted: 2002-01-31
Abstract: PCT No. PCT/FI97/00155 Sec. 371 Date Sep. 10, 1998 Sec. 102(e) Date Sep. 10, 1998 PCT Filed Mar. 10, 1997 PCT Pub. No. WO97/33745 PCT Pub. Date Sep. 18, 1997A method of manufacturing a core, especially a spiral core, from superimposed plies of board produced by winding, gluing, and drying them, is provided. The method is practiced so that the moisture content of at least some of the board plies entering the winding stage differ from each other in order to provide a stepwise moisture structure within the core wall. This decreases unfavorable stresses which are produced in the drying stage if a core is manufactured from plies having equal moisture content.
Patent DE-69738049-D1 (DE)
Inventor: ARIOLI ANTONIO
IPC: C12N1/19
Filed: 1997-06-24
Granted: 2007-10-04
Abstract: The present invention relates generally to isolated genes which encode polypeptides involved in cellulose biosynthesis in plants and transgenic plants expressing same in sense or antisense orientation, or as ribozymes, co-suppression or gene-targeting molecules. More particularly, the present invention is directed to a nucleic acid molecule isolated from Arabidopsis thaliana, Oryza sativa, wheat, barley, maize, Brassica spp., Gossypium hirsutum and Eucalyptus spp. which encode or an enzyme which is important in cellulose biosynthesis, in particular the cellulose synthase enzyme and homologues, analogues and derivatives thereof and uses of same in the production of transgenic plants expressing altered cellulose biosynthetic properties.
Patent DE-69801429-D1 (DE)
Inventor: BELMONT ANDRE
IPC: H01L21/66
Filed: 1998-04-09
Granted: 2001-09-27
Abstract: The invention relates to a process for manufacturing a card with multiple tips, designed in particular for testing semiconductor chips or integrated circuits before encapsulation thereof and comprising an oxidised silicon substrate 10 on the two opposite surfaces, one of the surfaces being provided with conducting strips connected to contacts in the form of tips 26. A thin metal layer 22 is deposited by vapour deposition in a vacuum or by cathode sputtering on one of the insulated surfaces of the monolithic substrate 10, and the conducting strips are obtained by means of a UV photolithography operation making use of a photosensitive resin, followed by etching of the thin metal layer 22 according to the location and shape of the tips 26. Another UV photolithography operation is then performed consisting in depositing a thick layer 24 of photosensitive resin on the thin etched layer, the resin then being revealed with the drawing 25 of the tips. The tips 26 are finally obtained by electroforming by means of a bath containing metal ions enabling electroformed pads corresponding to the shape of the drawings 25 to be achieved.
Patent DE-69804446-D1 (DE)
Inventor: THASTRUP OLE
IPC: C12Q1/48
Filed: 1998-04-07
Granted: 2002-05-02
Abstract: Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Fluorescent Protein (GFP,EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent protein kinase, a cyclin-, calmodulin- or phospholipid-dependent or mitogen-activated serine/threonin protein kinase, a tyrosine protein kinase, or a protein phosphatase (e.g. PKA, PKC, Erk, Smad, VASP, actin, p38, Jnk1, PKG, IkappB, CDK2, Grk5, Zap70. p85, protein-tyrosine phosphatase 1C, stat5, NFAT, NFkappaB, RhoA, PKB). An influence modulates the intracellular signaling pathway in such a way that the luminophore is being redistributed or translocated with the component in living cells in a manner experimentally determined to be correlated to the degree of influence. Measurement of redistribution is performed by recording of light intensity, fluorescense lifetime, polarization, wavelength shift, resonance energy transfer, or other properties by an apparatus consisting of e.g. a fluorescence microscope and a CCD camera. Data stored as digital images are processed to numbers representing the degree of redistribution. The method can be used as a screening program for identifying a compound that modulates a component and is capable of treating a disease related to the function of the component.
Patent DE-69806024-D1 (DE)
Inventor: VAN DOORN LEEN-JAN
IPC: C12Q1/70
Filed: 1998-09-14
Granted: 2002-07-18
Abstract: The present invention relates to a method for detection and/or identification of HPV present in a biological sample, comprising the steps of amplification of HPV polynucleic acids and of hybridization of said amplified polynucleic acids to a number of probes. By means of PCR, a short fragment of the L1 gene of HPV is amplified. The amplimers are then contacted with probes that specifically hybridize to said short fragment of the L1 gene of either one or more than one HPV type. A preferred format is the reverse hybridization technique, more particularly the LiPA technique. The invention also relates to primers and probes to be used in a method of detection and/or identification of HPV and to a diagnostic kit to perform said method. The invention further relates to new HPV sequences.
Patent DE-69814391-D1 (DE)
Inventor: BAGLIN NEIL ERNEST
IPC: G08B13/08
Filed: 1998-07-16
Granted: 2003-06-12
Abstract: A device for indicating/limiting the overall displacement of a movable member from a preset position, wherein the device (1) is selectively positionable to accomodate variation in allowable displacement of the movable member (32, 38, 39, 42, 49, 50, 52) prior to preventing displacement of the movable member or for providing an indication of any such displacement of the member.
Patent DE-69821415-D1 (DE)
Inventor: BENE BERNARD
IPC: A61M1/34
Filed: 1998-08-07
Granted: 2004-03-11
Abstract: The procedure for regulating the concentration of sodium in a dialysis fluid at a predetermined level so that the fluid inside the patient tends towards a desired concentration as the patient's blood and dialysis fluid are circulated on either side of a semi-permeable membrane (4) in a dialyser (1) consists of determining the concentration of sodium in the dialysis fluid, the desired concentration, the perfusion flow rate and the concentration in the perfusion fluid and adjusting the dialysis fluid concentration accordingly. The concentration of sodium in the dialysis fluid is determined from a set formula based on the desired concentration, the concentration in the perfusion fluid, the fluid flow rate and the dialyser separating capacity. The separating capacity is determined by circulating at least two dialysis fluids with different conductivities, taking two or more conductivity measurements before and after the dialyser, and calculating the separation capacity from the values obtained, using a second formula.
Patent DE-69825469-D1 (DE)
Inventor: CHARLTON STEPHEN
IPC: E21B17/10
Filed: 1998-11-16
Granted: 2004-09-09
Abstract: A casing centralizer is provided. Such a casing centralizer includes a tubular body substantially comprised of a plastics material and having an innermost surface, an outermost surface, and opposed ends. The tubular body is adapted to surround a well casing and to centralize the well casing within it wellbore. The innermost surface of the tubular body defines at least one recess that extends longitudinally and radially tapers along at least a portion of the innermost surface. An associated wellbore casing apparatus, downhole tool, and method of cementing a well casing into a well bore are also provided.
Patent DE-69827031-D1 (DE)
Inventor: WENTINK MENZO
IPC: H04L47/80
Filed: 1998-12-02
Granted: 2004-11-18
Abstract: The present invention describes a protocol with which it is possible to establish a connection suitable for voice communication in a network such as internet. In a first step, a PATH message is transmitted from an initiator ( 1 ) to a called station ( 2 ). In a second step, an RESV message is transmitted from the called station ( 2 ) back to the initiator ( 1 ), along the same route ( 23 ) followed by the PATH message. If either the initiator ( 1 ), or the called station ( 2 ), or both, contain information in the PATH message and/or the RESV message that indicates payment willingness, each router ( 22 ) along the route ( 23 ) will reserve a part of its capacity for a direct connection.
Patent DE-69833927-D1 (DE)
Inventor: ROBINET FRANCK
IPC: H01R13/58
Filed: 1998-10-05
Granted: 2006-05-11
Abstract: When grip is mounted in socket unit, the entering cable (23) can be clamped in one of three positions as desired. At least two clamping plates (28A,28B) stretching in different directions, comprising central clamping plate and clamping shoulder plate, having at least one fixing clamp screw (30).
Patent DE-69841395-D1 (DE)
Inventor: BOVA DAVID J
IPC: A61K9/24
Filed: 1998-07-31
Granted: 2010-01-28
Abstract: An extended or sustained release composition for oral administration to alter serum lipid levels in an individual without causing drug-induced hepatotoxicity, rhabdomyolysis or myopathy, the composition comprising from 250 mg to 3000 mg of nicotinic acid or a compound metabolised to nicotinic acid by the body selected from the group consisting of nicotinyl alcohol tartrate, d-glucitol hexanicotinate, aluminium nicotinate, niceritrol, d,l-alpha-tocopheryl nicotinate, 6-OH-nicotinic acid, nicotinaria acid, nicotinamide, nicotinamide-N-Oxide, 6-OH-nicotinamide, NAD, N-methyl-2-pyrridine-8-carboxamide, N-methyl-nicotinamide, N-ribosyl-2-pyridone-5-carboxide, N-methyl-4-pyridone-5-carboxamide, bradilian, sorbinicate, hexanicite, ronitol, and methyl, ethyl, propyl or butyl alcohol esters of nicotinic acid or combinations thereof, coated with an immediate release coating of from 0.1 mg to 80 mg of an HMG-CoA reductase inhibitor.
Patent DE-69900777-D1 (DE)
Inventor: EVRARD ALAIN
IPC: B65G47/90
Filed: 1999-02-09
Granted: 2002-02-28
Abstract: The invention concerns a transfer device for hollow bodies comprising an open end forming a neck (20), comprising at least pliers (11) for gripping the hollow body by the outer part of its neck and consisting of two synchronously articulated jaws (12, 13) and drive means for controlling the opening and closing of the jaws sequentially and synchronously. The invention is characterised in that said drive means comprise at least a fluid actuator (28) driving at least one jaw (12, 13).
Patent DE-69902737-D1 (DE)
Inventor: HEIKKILAE HEIKKI
IPC: C07H1/08
Filed: 1999-11-16
Granted: 2002-10-10
Abstract: The invention relates to a method of producing xylitol and erythritol from arabinoxylan-containing material. According to the invention, the arabinoxylan-containing material is hydrolyzed and xylose and arabinose are separated from the obtained hydrolysate, whereafter the xylose is reduced to xylitol, and the xylitol is recovered, and the arabinose is subjected to alkaline oxidation to obtain erythronic acid which is reduced to erythritol, and the erythritol is recovered.
Patent DE-69908594-D1 (DE)
Inventor: REIS E
IPC: H05K1/02
Filed: 1999-02-19
Granted: 2003-07-10
Abstract: A surface mount technology compatible electromagnetic interference (EMI) gasket assembly includes an electrically conductive gasket material, a solderable electrically conductive support layer, and an adhesive or other mechanical assembly for affixing the electrically conductive gasket material to the support layer.
Patent DE-69909041-D1 (DE)
Inventor: BRAUN SERGE
IPC: A61K31/7088
Filed: 1999-09-30
Granted: 2003-07-31
Abstract: Described is the use of magnesium (Mg<2+>) for the preparation of a therapeutic composition for the introduction of a polynucleotide into a cell in vivo.