baber/WOPTO huggingface dataset:
Patent CA-3130488-A1 (CA)
Inventor: LIU DAVID R
IPC: C12N15/11
Filed: 2020-03-19
Abstract: The present disclosure provides new prime editor guide RNAs for prime editing, constructs for prime editing, and methods for using same. In addition, the present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis (e.g., insertion or deletion). The nucleotide change can include a single-nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a prime editor RNA (PEgRNA). The prime editor guide RNA comprises an extension arm that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to an endogenous DNA sequence, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incorporated into the target DNA molecule.
Patent CA-3132112-A1 (CA)
Title: Compounds useful in hiv therapy
Inventor: DE LA ROSA MARTHA ALICIA
IPC: A61K31/7076
Filed: 2020-03-04
Abstract: The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.
Patent CA-3134658-A1 (CA)
Inventor: JONES JACOB
IPC: A61M13/00
Filed: 2020-03-18
Abstract: A filter cartridge assembly is disclosed, which includes a housing having a reservoir for collecting fluids entering the housing through a gas return path, a sensor located within the reservoir for detecting a fluid level therein, and a backer plate positioned within the housing adjacent an inlet port to the reservoir and including fluid management structure to shield the sensor from fluid entering the reservoir from the gas return path through the inlet port and causing a false indication of the fluid level in the reservoir.
Patent CA-3136589-A1 (CA)
Title: Container for the storage and/or transport of batteries and the use of such a container
Inventor: HENDRICKX HENDRIK
IPC: H01M50/383
Filed: 2021-10-28
Abstract: Container (1) for the transport or storage of batteries, the container (1) having an internal storage space having a volume, the container (1) comprising walls (4, 11) surrounding the storage space on all sides, the container (1) having a lid (3) to close the storage space, wherein, in a state wherein the storage space is closed by the lid (3), the lid (3) constitutes a top wall of the storage space, wherein one or more of said walls (4,11) are provided with one or more openings (19) for venting gas under pressure from the storage space to the outside air, the one or more openings (19) having a total surface area of at least 1.0 square centimetre per litre volume of the storage space, wherein a layer of flame-retardant material (17) extends over the one or more openings (19), the flame-retardant material being made of steel fibres or mineral fibres.
Patent CA-3138213-A1 (CA)
Inventor: MEERDINK JAN JOHANNES
IPC: B65G47/52
Filed: 2020-05-01
Abstract: L'invention concerne un système et un procédé de transfert automatique de parties de carcasse qui passent de suspendues au niveau d'un premier support à suspendues au niveau d'un deuxième support. Les parties de carcasse peuvent être une demi-carcasse qui peut avoir été éviscérée et nettoyée. Le premier support peut être un jambier standard industriel ou un support unique ou un support DeboFlex de Marel, par exemple un support Euro. Le deuxième support peut être un support unique, par exemple un support Euro, ou un support DeboFlex de Marel.
Patent CA-3138581-A1 (CA)
Title: Pic1 peptide compositions and methods of use thereof for treatment of hypoxic ischemic encephalopathy
Inventor: KRISHNA NEEL K
IPC: A61K45/06
Filed: 2020-05-28
Abstract: A method of treating hypoxic ischemic encephalopathy (HIE) is described in which a classical complement pathway inhibitor is administered to a neonate. The classical pathway inhibitor can be PIC1, and may have one or more PEG moieties. Treatment of the neonate with the classical complement pathway inhibitor can inhibit inflammation and oxidative damage, such as might arise from ischemia-reperfusion injury. Improvement in fine motor performance, spatial memory and may be achieved. The method may be effective to treat or prevent cerebral palsy.
Patent CA-3138817-A1 (CA)
Inventor: WESTERGAARD ANDERSEN KENNETH
IPC: B65G47/51
Filed: 2020-05-01
Abstract: L'invention concerne un maillon de courroie transporteuse modulaire, du type utilisé dans des courroies transporteuses sans fin assemblées à partir d'une pluralité de tels maillons, le maillon selon l'invention comprenant un corps principal s'étendant dans le sens de la largeur du maillon, et une pluralité de parties oeil s'étendant vers l'avant et vers l'arrière à partir dudit corps principal, lesdites parties oeil étant espacées dans le sens de la largeur du maillon de courroie modulaire, des parties oeil s'étendant vers l'avant étant décalées par rapport à des parties oeil s'étendant vers l'arrière, de sorte que lorsque deux maillons de courroie transporteuse modulaires sont poussés ensemble, les parties d'oeil sur un maillon s'adaptent entre elles entre des parties oeil sur l'autre maillon de courroie modulaire. Le maillon selon l'invention se caractérise en ce qu'il est limité latéralement par deux côtés et en ce que les parties oeil les plus extérieures de chaque côté comportent une découpe, de sorte que la largeur du maillon de courroie transporteuse modulaire soit plus petite à l'intérieur de la découpe qu'à l'extérieur de la découpe.
Patent CA-3139830-A1 (CA)
Inventor: ZHU XIAOHUA
IPC: A24F40/46
Filed: 2020-05-14
Abstract: Il est décrit un dispositif de chauffage sans brûlement sans contact comprenant un élément céramique chauffant et un composant de support de produit à fumer. L'élément céramique chauffant comprend un corps de chauffage cylindrique possédant un canal poreux et un circuit de chauffage qui est disposé sur le corps de chauffage pour chauffer l'air passant dans le canal poreux. L'assemblage de support de produit à fumer comprend un tube de préchauffage et une pièce de blocage placée dans une cavité définie par le tube de préchauffage, la division de la cavité en une première cavité pour placer le produit à fumer et préchauffer ce dernier et une deuxième cavité pour placer au moins une partie de l'élément céramique chauffant. Au moins une partie de ce dernier est disposée dans la cavité définie par le tube de préchauffage pour préchauffer la cavité, améliorer l'efficace de chauffage et permettre au produit à fumer d'être chauffé uniformément.
Patent CA-3142308-A1 (CA)
Inventor: Geng Dongjiu
IPC: G06F11/16
Filed: 2020-05-29
Abstract: L'invention concerne un procédé, un appareil et un système de recouvrement d'erreur. Selon le mode de réalisation de la présente invention, au moins deux CPU dans un mode bloqué peuvent sortir du mode bloqué quand une erreur se produit dans au moins une CPU, et une CPU dans laquelle une erreur se produit et le type de l'erreur sont déterminés ; et sur cette base, quand l'erreur est réparable, la CPU dans laquelle l'erreur se produit peut être réparée conformément à une CPU qui fonctionne correctement, ce qui permet d'aider lesdites CPU à fonctionner à nouveau à un endroit où un programme de service est interrompu. Par conséquent, le mode de réalisation de la présente invention peut améliorer la capacité de recouvrement d'erreur d'un système en mode bloqué ainsi que la fiabilité du système.
Patent CA-3142612-A1 (CA)
Title: Valve shaft locking mechanism
Inventor: SCHNEIDER SEBASTIAN
IPC: B65D90/58
Filed: 2020-07-03
Abstract: The invention relates to an extraction fitting for liquid containers, in particular for connection to the outlet nozzle or the outlet opening of a transport and storage container for liquids, comprising a fitting housing (11), in which a valve body, which can be pivoted by a valve shaft (16), is arranged for opening and closing a flow cross section of an outlet pipe, wherein the valve shaft (16) is arranged having a connection end for connection to the valve body in the outlet pipe of the fitting housing (11) and having an actuation end leading out of the fitting housing (11) through a housing dome (21) formed on the fitting housing (11), wherein, in order to axially secure the valve shaft (16) in the fitting housing (11) between the housing dome (21) and a valve shaft portion received in the housing dome (21), a form-fitting engagement is produced.
Patent CA-3142791-A1 (CA)
Title: Balloon for expanding an orifice
Inventor: JAMES ANDREW E
IPC: A61M29/02
Filed: 2020-06-12
Abstract: A balloon is disclosed for expanding an orifice. The balloon comprises a hollow body having a head. The body is closed at a distal end and open at a proximal end. The head extends from the distal end. The balloon also comprises a hollow neck positioned between the open proximal end and the distal end of the body. In the balloon, a wall thickness of the neck is greater than a wall thickness of the head. In a variation, the balloon can be configured such that, when the balloon is inflated, the head expands in a radial direction greater than in the longitudinal direction and a diameter of the body remains approximately constant during inflation. Also disclosed is a system for expanding an orifice. The system includes such a balloon and an inflation device for inflating the balloon. Also disclosed is a kit comprising the system and a container. Further, disclosed is a mould and a method for forming the balloon.
Patent CA-3143374-A1 (CA)
Title: Battery management system for parallel charging of battery modules
Inventor: THORSOE JAN
IPC: H02J7/00
Filed: 2020-06-11
Abstract: The invention relates to a battery system which includes a master controller (101) arranged to determine a current control signal for controlling a charging current from a current source (102), one or more battery modules (103) comprising battery module terminals, a connection arrangement (121) arranged to electrically connect the one or more battery modules in parallel via the battery module terminals to enable parallel charging/discharging via individual switches (104), where each battery module comprises at least one battery cell (105), and a slave control unit (106) configured to monitor a battery condition of the battery module and to determine a battery event based on the battery condition, where the master controller is configured to determine the current control signal dependent on the battery event from any of the battery modules so as to cause a reduction or increase of the charging current, and to determine the current control signal dependent on battery module capacities of the one or more battery modules.
Patent CA-3144010-A1 (CA)
Inventor: MAPLES PHILLIP B
IPC: A61J1/16
Filed: 2020-07-16
Abstract: Certains modes de réalisation de la présente invention concernent un système de transport et d'emballage de tissus biologiques, lequel comprend un emballage primaire, un emballage secondaire et un emballage tertiaire. Chacun des emballages primaire, secondaire et tertiaire est stérilisé avant l'emballage d'un tissu biologique en son sein. L'emballage primaire comprend une poche, et un premier plateau et un premier couvercle conçus pour être fixés l'un à l'autre par encliquetage amovible de façon à former un contenant à double coque. L'emballage secondaire est conçu pour contenir l'emballage primaire et se verrouiller avec celui-ci. L'emballage tertiaire est conçu pour contenir l'emballage secondaire et se verrouiller avec celui-ci.
Patent CA-3144115-A1 (CA)
Inventor: FRENCH ARRON
IPC: E04G23/02
Filed: 2020-07-02
Abstract: L'invention concerne un dispositif de réparation d'un trou dans une structure de paroi. Ledit dispositif comprend : un corps ; une pluralité d'éléments de bras montés par rapport au corps, un élément de sangle s'étendant entre au moins deux des éléments de bras ; et un élément mobile associé au corps. Le déplacement de l'élément mobile actionne la pluralité d'éléments de bras à se déplacer par rapport au corps entre une condition rétractée et une condition étendue dans laquelle l'élément de sangle est étiré de manière relativement serrée entre les éléments de bras pour former une surface sensiblement plane.
Patent CA-3144758-A1 (CA)
Title: Urinary catheter and method of catheterising a bladder using an actively deflectable urethral catheter and a deflection mechanism
Inventor: MIDDLETON IAN S
IPC: A61M25/10
Filed: 2020-09-11
Abstract: A urinary catheter with deflectable tip, comprising a hollow catheter body configured to be inserted within the urethra of a patient, the catheter body having an elongate portion, a tip portion near a distal end of the elongate portion and an engagement portion spaced from the distal end where a user can grasp the catheter, the tip portion being deflectable for the purpose of steering the catheter within the urethra to allow the catheter to follow a natural curvature of the urethra, the tip portion being movable from a generally straight condition to a deflected condition wherein deflection of the tip portion occurs while the elongate portion remains generally straight.
Patent CA-3144847-A1 (CA)
Title: Packaging for pharmaceutical products
Inventor: ROS NICO
IPC: B65D81/38
Filed: 2020-06-23
Abstract: The invention relates to a packaging for pharmaceutical products, comprising a primary packaging (3) for receiving one or more doses of a pharmaceutical product and a secondary packaging designed as a cardboard box (1) in which the primary packaging (3) is housed, the primary packaging (3) is arranged in an insulating sleeve (2) comprising a latent heat storage material.
Patent CA-3145152-A1 (CA)
Inventor: AYRE GARETH DAVID
IPC: F41H5/20
Filed: 2020-06-18
Abstract: OVERPRESSURE PROTECTION SYSTEM FOR A MAGAZINE An overpressure protection system (30) for a magazine (10) for storing explosive materials. The magazine (10) comprisesa wall (12) which defines an internal chamber (14) for housing the explosive materials, with a first aperture (20) defined in the wall (12). Theoverpressure protection system (30) is configured toclose the first aperture (20). The system (30) comprises a burst disc diaphragm (32) for covering the first aperture (20), and a protective cover (34) for locating outside of the chamber (14) and over the burst disc diaphragm (32). The protective cover (34) isspaced apart from the burst disc diaphragm (32) to form a cavity (38) with an opening (36) for venting fluid from the cavity (38). [Figure 7]
Patent CA-3145562-A1 (CA)
Inventor: HIGHLANDER PETER D
IPC: A61B10/02
Filed: 2020-06-28
Abstract: Methods of harvesting cancellous bone and bone marrow include extracting loosened cancellous bone and bone marrow  including a liquid component thereof  to a collection container that has a first cup and a suction port to which a suction source is connected. After extraction, the suction source is disconnected and a lid of the collection container is removed and replaced with a lid having a plunger with a press head that is configured to filter the extracted liquid by depressing the plunger toward a bottom of the first cup. The filtered liquid is poured through a suction port into a second cup while depressing the plunger, thereby separating the liquid from a semi-solid mass of cancellous bone that remains. The bone is extracted through a cortical opening in the femur, tibia, or calcaneus, or from an intermedullary canal that is preferably formed by reaming of the tibia using an orthopedic reamer.
Patent CA-3148598-A1 (CA)
Inventor: TSCHUMPERLIN DANIEL J
IPC: A61P35/00
Filed: 2020-07-29
Abstract: La présente invention concerne des méthodes de traitement ou de prévention de maladies et d'états associés à une fibrose tissulaire.
Patent CA-3149273-A1 (CA)
Inventor: XU JIANPING
IPC: C12N9/22
Filed: 2020-09-18
Abstract: La présente invention concerne des procédés et des compositions pour modifier un site cible dans le génome d'une cellule. L'invention concerne également des protéines de fusion comprenant un ou plusieurs domaines de liaison à l'ADN et un ou plusieurs domaines hétérologues, tels que des domaines de modification d'ADN, reliés par des séquences de lieur améliorées. L'invention concerne des polynucléotides à codon optimisé codant pour des protéines de fusion comprenant un ou plusieurs domaines de liaison à l'ADN et un ou plusieurs domaines hétérologues reliés par des séquences de lieur améliorées.
Patent CA-3155452-A1 (CA)
Title: Processus et appareil d'extraction multiphase de substances actives d'une biomasse
Inventor: REED RANDY
IPC: A61K36/185
Filed: 2020-10-23
Abstract: L'invention concerne un procédé de réalisation d'une extraction multiphase de biomasse végétale pour obtenir des substances actives. Le procédé utilise une nouvelle technique d'extraction par lyophilisation pour obtenir une fraction de terpène volatile à partir de matière végétale congelée. En particulier, le procédé divulgué fournit des extraits de terpène ayant des compositions qui ressemblent fortement à celles de la matière végétale parent.
Patent CA-3157438-A1 (CA)
Inventor: EPSTEIN DAVID MICHAEL
IPC: C12Q1/6886
Filed: 2020-11-20
Abstract: The present invention relates to a method and system for identifying and validating pairs of candidate antigens and their cognate antigen-specific T lymphocytes that are useful for validating the immunogenic activity of paired antigen and TCR sequences. The method includes, inter alia, steps of determining one or more splice variants that are more highly transcribed in a sample obtained from cohort of patients compared to a reference sample, determining one or more amino acid sequences that occur in an amino acid translation of said one or more splice variants but not in the corresponding splice variant in the reference sample, and predicting HLA binding of the amino acid sequences in order to identify candidate shared antigen. The present invention also relates to methods of characterising and/or treating a medical condition, including cancer.
Patent CA-3157475-A1 (CA)
Inventor: MITROVIC MIROSLAV
IPC: F16L37/10
Filed: 2020-10-29
Abstract: A connector for use with a dialyzer to connect a conduit from a dialyzer with a conduit from a dialysate source. The connector includes a sleeve (female component) and a collet (male component). The sleeve has a generally cylindrical shape with an opening at one end having a circular shape with at least one slot positioned along the periphery of the circular shape. The sleeve also includes at least one flexible finger having a barb at a free end. The collet is configured to be housed within an interior chamber of the sleeve and has first and second gaps to house the barbs and first and second deflectable flanges to lock into recesses in a conduit.
Patent CA-3158104-A1 (CA)
Title: Automated lifecycle management flexible scaling and dynamic resource allocation for virtualized cable data plane applications
Inventor: ORBAN MIRCEA
IPC: H04L41/0895
Filed: 2020-11-20
Abstract: Systems and methods to support flexible scaling and dynamic resource allocation for virtualized cable data plane applications. The system includes a head end operating together with a node to provide data to customer devices. A container operating on at least one server included in the head end includes a data plane application that provides packets of data for transmission to the node. The data plane application is instantiated with at least one of a virtual networking function and a computing resource function.
Patent CA-3160904-A1 (CA)
Title: Lubricant composition for reduced engine sludge
Inventor: DINGWELL LISA
IPC: C10M133/04
Filed: 2022-05-27
Abstract: The present disclosure describes lubricant compositions effective to minimize average engine sludge through selection of lubricant additives that control the total nitrogen as well as the origin of the nitrogen in the lubricant composition. In aspects, the lubricant compositions herein include at least a base oil of lubricating viscosity, a dispersant system, and at least one antioxidant.
Patent CA-3161525-A1 (CA)
Inventor: HAHN JEONGWON
IPC: D06F34/28
Filed: 2020-12-07
Abstract: A washing machine according to an aspect disclosed herein comprises: a display unit that displays a washing course and a first washing option set corresponding to the washing course; an input unit that receives, from a user, a user's option change command for changing at least one washing option among a plurality of washing options included in the first washing option set; a storage unit that stores the washing option set including the at least one changed washing option; and a control unit that performs controlling to change the first washing option set to a second washing option set when the number of times that washing option sets are stored meets or exceeds a predetermined number, wherein the second washing option set is based on the at least one washing option.
Patent CA-3163415-A1 (CA)
Title: Therapie genique
Inventor: AZZOUZ MIMOUN
IPC: C12N9/12
Filed: 2021-02-02
Abstract: La présente divulgation concerne des cassettes de transcription comprenant des acides nucléiques codant pour RuvBL1 et/ou RuvBL2 et l'utilisation desdits vecteurs en thérapie génique pour le traitement de maladies neurodégénératives qui résultent de l'expression d'expansions de répétition polymorphiques de la séquence de répétition hexanucléotidique GGGGCC (SEQ ID NO : 5) dans le premier intron du gène C9ORF72; et des compositions pharmaceutiques comprenant lesdits vecteurs et comprenant des utilisations et des procédés pour traiter des maladies neurodégénératives.
Patent CA-3166609-A1 (CA)
Inventor: CHIN HWA SUP
IPC: A23K10/16
Filed: 2021-01-27
Abstract: The present invention relates to a composition for preventing or treating cancer, comprising, as an active ingredient, Weissella cibaria WIKIM28 or a culture thereof isolated from kimchi.The Weissella cibaria WIKIM28 or a culture thereof according to the present invention exhibits excellent anticancer activity, and thus can be usefully used as a composition for use in the treatment, prevention, or improvement of cancer in humans or animals.
Patent CA-3169064-A1 (CA)
Inventor: LUIS DAVID
IPC: F16L11/12
Filed: 2022-07-26
Abstract: L'invention concerne un tuyau (4) de transport aéraulique d'un produit d'isolation en vrac pour une machine de soufflage du produit isolant, le tuyau (4) s'étendant suivant une direction d'allongement principal (P) longitudinale (L) et comprenant au moins une paroi cylindrique (20) qui délimite un espace configuré pour la circulation au moins du produit isolant en vrac, le tuyau (4) étant caractérisé en ce que la paroi cylindrique (20) comprend une pluralité de tronçons (28), au moins deux des tronçons (28) comprenant chacun au moins un orifice d'évacuation (40) de manière à former au moins deux tronçons percés (42), le tuyau (4) comprenant au moins deux moyens d'obturation (48) mobiles en translation suivant la direction longitudinale (L) autour de la paroi cylindrique (20), chacun des moyens d'obturation (48) étant apte à recouvrir spécifiquement un des tronçons percés (42).
Patent CA-3170874-A1 (CA)
Inventor: ELMS PHILLIP J M
IPC: G01N35/08
Filed: 2021-03-08
Abstract: Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object.