baber/WOPTO huggingface dataset:
Patent JP-2006166334-A (JP)
Title: Copying system for literary work, image forming apparatus, image forming method, and control program and storage medium for image forming apparatus
Inventor: TACHIBANA YOSHIRO
IPC: H04N1/00
Filed: 2004-12-10
Abstract: <P>PROBLEM TO BE SOLVED: To provide a copying system for a literary work, an image forming apparatus, an image forming method, and a control program and storage medium for the image forming apparatus capable of certifying that a user copies a literary work after paying a proper copyright fee while surely collecting the copyright fee from the user.  <P>SOLUTION: The image forming apparatus includes: an identification information extract means for extracting identification information to identify the literary work from copyright protection information when discriminating that the literary work includes the copyright information; a request means for transmitting the identification information extracted by the identification information extract means to a copyright management server to request the server to transmit the copyright information; a requisition means for displaying the copyright information received from the server responding to the request to send a bill of the copyright fee to the user; and an attaching means for attaching paid-up information for certifying that the copyright fee is paid by the user to stored image data when the image forming apparatus discriminates the user agrees with the requisition of the copyright fee.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006166718-A (JP)
Title: New method for producing d-talitol from d-psicose as raw material
Inventor: YOSHIHARA KAZUTOSHI
IPC: C12R1/845
Filed: 2004-12-13
Abstract: <P>PROBLEM TO BE SOLVED: To provide new microorganisms containing enzymes capable of converting D-psicose into D-talitol to produce the D-talitol in a large amount at a low cost.  <P>SOLUTION: This method for producing the D-talitol, comprising bringing the D-psicose of raw material into contact with a microorganism to convert into the D-talitol, is characterized by using a strain of genus selected from the group consisting of genuses: Rhizopus, Absidia, Mucor and Gongronella which are microorganisms of Zygomycetes having abilities for converting the D-psicose into the D-talitol, as the microorganism. The microorganism is a strain belonging to Rhizopus oryzae, Rhizopus acetoinus, Rhizopus oligosporus, Rhizopus stolonifer, Absidia coerulea, Absidia ramose, Mucor rouxianus, Mucor hiemalis, Mucor javanicus, Mucor racemosus, or Gongronella butleri, or a mutant thereof.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006169753-A (JP)
Title: Smart key system for vehicle
Inventor: MITSUHAYASHI HIRONORI
IPC: B60R25/04
Filed: 2004-12-14
Abstract: <P>PROBLEM TO BE SOLVED: To provide a smart key system for a vehicle, which bears only small processing load, and can positively execute regular verification processing.  <P>SOLUTION: According to the smart key system for a vehicle, after starting of a regular verification, if another trigger signal for requesting another regular verification at a predetermined period is issued at some midpoint of the period of the former verification, starting timing of the period of the regular verification by one of a former trigger signal and the latter trigger signal is shifted so as to coincide with the period of the regular verification by the other trigger signal, to thereby make verification timing of the former trigger signal coincide with verification timing of the latter trigger signal. Thus the regular verification request by the former trigger signal and the regular verification request by the latter trigger signal are synthesized with each other as a single regular verification request.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006169575-A (JP)
Title: Semiconductor device manufacturing method
Inventor: FURUYA AKIRA
IPC: H01L21/285
Filed: 2004-12-15
Abstract: <P>PROBLEM TO BE SOLVED: To provide a semiconductor device manufacturing method having a step of removing excessive deposit species impairing a self-limiting surface reaction.  <P>SOLUTION: The semiconductor device manufacturing method has a step of depositing a thin film on a substrate by alternately feeding a first raw material gas and a second raw material gas in a reaction furnace. The surface of the substrate is irradiated with plasma either after the first raw material gas is fed and before the second raw material gas is fed, or after the second raw material gas is fed and before the first raw material gas is fed.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005202382-A (JP)
Title: Optical printed circuit board, surface mounting type semiconductor package, and mother board
Inventor: OTA MASARU
IPC: G02B6/122
Filed: 2004-12-15
Abstract: <P>PROBLEM TO BE SOLVED: To make high in processing speed and low in noise inexpensively in various electronic equipment by inexpensively supplying an optical printed circuit board for optical wiring, a surface mounting type semiconductor package, and a mother board.  <P>SOLUTION: This optical printed circuit board uses: (a) a hardening resin which is characterized in that it has thermosetting or ultraviolet ray setting property, with Tg ≥130°C at completion of setting; and (b) a transparent plastic composite sheet which is characterized in that a filamentary inorganic filler is the essential component, that a straight light transmissivity in the ray of 850 nm wavelength is ≥40%, and that a coefficient of thermal expansion at 25-130°C is ≤40 ppm/°C. This surface mounting type semiconductor package uses the optical printed circuit board, and also this mother board uses the semiconductor package.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patent JP-2006167617-A (JP)
Title: Treatment method of soil polluted with arsenic
Inventor: IDA TORU
IPC: B09C1/02
Filed: 2004-12-16
Abstract: <P>PROBLEM TO BE SOLVED: To provide a treatment method of soil polluted with arsenic by suppressing elution of arsenic to low enough to satisfy the ambient environmental quality standard by making the arsenic in the arsenic-polluted soil insoluble even if the compound form of arsenic in the arsenic-polluted soil is an organic arsenic compound or an inorganic compound of trivalent or pentavalent arsenic.  <P>SOLUTION: The treatment method of soil polluted with arsenic involves heating the arsenic-polluted soil at a temperature in a range from 200 to 700°C and adding and mixing a calcium compound and water to and with the heated arsenic-polluted soil. Alternatively, the treatment method of soil polluted with arsenic involves heating a mixture of the arsenic-polluted soil with a calcium compound at a temperature in a range from 200 to 700°C and adding and mixing water to and with the heated mixture.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006174181-A (JP)
Title: Modem for power line communication
Inventor: TADACHI TERUO
IPC: H04B3/56
Filed: 2004-12-16
Abstract: <P>PROBLEM TO BE SOLVED: To suppress a transmission loss of a power line communication signal, and make it easy to acquire approval of safety specifications of a modem used as a load.  <P>SOLUTION: The modem is provided with a voltage conversion means 11 which converts voltage of a commercial power line to AC voltage or DC voltage which is lower voltage than the source, and supplies to the modem 20; a transformer for signal transmission 12; two input terminals 10a, 10b which input the commercial power line voltage; and two output terminals 10c, 10d which output the AC voltage or the DC voltage of lower voltage; connects the input side of the voltage conversion means 11 to the input terminals 10a, 10b through a 1st high impedance means 13, 13; connects the output side to the output terminals 10c, 10d through a 2nd high impedance means 14, 14; connects a primary winding of the signal transmission transformer 12 to the input terminals 10a, 10b; and connects the secondary winding to the output terminals 10c, 10d.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006169693-A (JP)
Title: Paper used for newspaper for offset printing
Inventor: WATANABE KUNIHIKO
IPC: D21H19/56
Filed: 2004-12-17
Abstract: <P>PROBLEM TO BE SOLVED: To provide a paper used for a newspaper for offset printing, without accompanying a sticking phenomenon and also markedly improved with opacity after the printing and ink-attaching property.  <P>SOLUTION: This paper used for the newspaper for offset printing is provided by having ≤45 g/m<SP>2</SP>unit weight, containing an olefin-based sizing agent in a pigment-coated layer having 0.3-3 g/m<SP>2</SP>dried amount of coating per one side surface, wherein, the olefin-based sizing agent consists mainly of a copolymer containing an olefin-based unsaturated monomer as a constituting monomer, its mass-average molecular weight is preferably 1,000-10,000, and the dried coated amount of the olefin-based sizing agent is made as preferably 0.005-0.15 g/m<SP>2</SP>.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005095661-A (JP)
Title: Disposable diaper
Inventor: MIYOSHI TAKAYUKI
IPC: A61F13/49
Filed: 2004-12-17
Abstract: <P>PROBLEM TO BE SOLVED: To provide a disposable diaper whose free part of a pair of tape fasteners is prevented from coming off a target tape even when the outer surface of the tape fasteners rubs the inner surface of underpants against each other.  <P>SOLUTION: A pair of tape fasteners 6 are attached to a side flap 14 in a back trunk circumferential area 10 of this diaper 1A to connect front and back trunk circumferential areas 8, 10. In the diaper 1A, the fasteners 6 consist of a first fiber nonwoven fabric formed of thermoplastic synthetic resin fiber and thermoplastic synthetic resin coated on almost all over the outer surface of the first fiber nonwoven fabric. An almost smooth first synthetic resin layer of the thermoplastic synthetic resin is formed on the outer surface of the tape fasteners.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patent JP-2006178736-A (JP)
Title: Open evidence trail confirmation system
Inventor: MATSUO MASATO
IPC: G06K19/00
Filed: 2004-12-22
Abstract: <P>PROBLEM TO BE SOLVED: To record the open of a package by a package receiver and to enable a package provider to confirm the open evidence trail of the package.  <P>SOLUTION: When a package receiver opens the package in the open evidence trail confirmation system, an open tag 10 attached to the package transmits tag ID wirelessly (S11). A radio gateway 20 receives the tag ID and transmits the received tag ID to a server 40 through a network 30 (S12). The server 40 receives the tag ID, extracts a record corresponding to the tag ID in an open record management table 50, records an open state as open, and records also an opening date. The package provider refers to the open record management table 50 to grasp the open state.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005191575-A (JP)
Title: Structure of gallium-nitride-based light-emitting diode, and method for manufacturing the same
Inventor: LAI MU-JEN
IPC: H01L27/15
Filed: 2004-12-24
Abstract: <P>PROBLEM TO BE SOLVED: To provide a structure of a light-emitting diode of a gallium-nitride-based semiconductor in which enhancement of an external effect is achieved, and to provide a method for manufacturing the diode.  <P>SOLUTION: A first contact spreading metal layer 208a is formed on a fibrous structure of a p-type gallium-nitride ohmic-contact layer 207, next second and third metal contact spreading layers 208b, 208c are formed on the first contact spreading metal layer, thereby a translucent conductive layer comprising p-type metal in three layers is formed; and the translucent conductive layer comprising p-type metal in three layers is alloyed at high temperature in an atmosphere containing oxygen or nitrogen, after that, it has preferred conductivity. In addition, contact uniformity in a surface direction of the p-type metal electrode p and the p-type gallium-nitride ohmic-contact layer are reinforced, thereby local light-emitting caused by unevenness of the second contact spreading metal layer in the third contact spreading metal layer is effectively prevented, and driving voltage is reduced, thereby making outer quantum efficiency improved.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patent JP-2006184519-A (JP)
Title: Label continuous body and its manufacturing method
Inventor: KOEDA AKIHIRO
IPC: G09F3/10
Filed: 2004-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a label continuous body that can store labels in a continuous state by partial cutting and that can cope with labels having different pitches, and to provide a method for manufacturing the continuous body.  <P>SOLUTION: Printed labels 2 are temporarily adhered to a strip mount sheet 3. Two labels 2 are temporarily adhered to the strip mount sheet 3 leaving a space in the width direction of the sheet 3, and partial cut 4 is done leaving a center portion in the width direction of the strip mount sheet 3. The label continuous body 1 before applying printing and partial cut 4 includes two lines of continuous labels disposed with spacing in the width direction of the strip mount sheet 3, the labels being continuously and temporarily adhered in the pitch (longitudinal) direction. After the two lines of continuous labels continuing in the pitch direction are printed by a printing mechanism, each label is cut by a partial cutting mechanism. The partial cut 4 is done to cut the strip mount sheet 3 in the width direction leaving the center portion in the width direction, and to cut the continuous label in the width direction to form the label 2.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006184648-A (JP)
Title: Light emitting display device and method for driving same
Inventor: CHIBA TORU
IPC: G09G3/20
Filed: 2004-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To eliminate luminance unevenness of light emitted by each organic EL element.  <P>SOLUTION: In the respective organic EL elements E11 to Enm, the light emitting luminance (light emitting efficiency) with respect to an input specified unit quantity of electricity is lowered with an increase in electric resistance value. A display panel 20 is formed by arraying pixels comprised of the organic EL elements E11 to Enm. The unit quantity of electricity corresponding to image data are input to the organic EL elements E11 to Enm and the elements E11 to Wnm emit light. A measuring circuit 14 detects the organic EL elements of the relatively high electric resistance value among the respective pixels. A light emission control circuit 16 relatively increases the unit quantity of electricity to be input for the organic EL elements having relatively high electric resistance value.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006186839-A (JP)
Title: Support structure for crystal vibrator
Inventor: SATO KOJI
IPC: H03H9/19
Filed: 2004-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide a support structure for a crystal raw plate of a crystal vibrator which has excellent joining property between a joining material and the crystal raw plate, reduces a twisting force applied to the crystal raw plate, and has two metal terminals.  <P>SOLUTION: In the present invention to solve the problem, the support structure for the crystal vibrator such that the crystal raw plate is supported by a support plate fixed to the two metal terminals airtightly penetrating a metal base is characterized in that a joining material is held in a recessed portion on a plate-thickness inside surface of the tip portion of the support plate on the side of the crystal raw plate and the recessed portion has a corner portion abutting against the crystal raw material plate. Further, the support structure is characterized in that a joining material is held in a recessed portion on the plate thickness inside surface of the tip portion of the support portion on the side of the crystal raw plate, a first recessed portion abuts against the crystal raw plate at two points of the corner portion, and a second recessed portion connects with the first recessed portion perpendicularly across a wall and is recessed from the plate thickness inside surface side of the support plate to a plate-thickness outside surface side on the plate thickness inside surface side of the support plate.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006184238-A (JP)
Title: Reset lever device and electronic timepiece equipped with the reset lever device
Inventor: HAGA TAICHI
IPC: G04B27/02
Filed: 2004-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide a reset lever device which is simple in form and with a simplified structure having a readily stabilized of operation, and to provide an electronic timepiece equipped with this reset lever device.  <P>SOLUTION: Between a reset position H2 which makes hand operation inoperable by a rotation drive source 4, when a winding stem 20 is set a pull-out position P1 for a needle turning and a non-reset position H1, which enables hand operation possible by the rotation drive source 4, when the winding stem 20 is set a normal position P0, the reset lever device 8 of the electronic timepiece 1 is supported in a rotatable state, in the directions J1, J2 by a frame 10. When the winding stem 20 is pulled out of the normal position PO to the pull-out position P1, and has a reset lever body 60 which the inhibition of a displacement from the non-reset position to the reset position is canceled and has a reset lever bias spring part 56, extending to the direction which the other end side intersects perpendicular to the reset lever body so as to act deviation force to the reset lever body from the non-reset position to the reset position, supported by the frame with a base body part 51 in one end side, which is formed with the other body to the reset lever body.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005538049-A (JP)
Title: ２元的ないし多元的ターゲティング及びその使用
IPC: C12Q1/68
Filed: 2003-04-30
Abstract: 【課題】            ターゲティングの特異性を向上すること。 【解決手段】        標的に機能性成分を提供する方法であって、ａ）２又は３以上のターゲティング成分を提供すること、但し、各ターゲティング成分は、ターゲティング部分及び再構成部分を含み、各ターゲティング部分は、前記標的の近接して位置する２又は３以上の別異部位の１つと特異的に結合し、再構成部分は、互いに接近したとき、集合して前記標的において機能性成分を構築する、及びｂ）前記複数のターゲティング成分を前記標的を含む環境と接触させ、前記標的における前記機能性成分の構築を誘発し、以って該機能性成分を前記標的に提供する方法。
Patent JP-2005531948-A (JP)
Title: 光付加／除去ノード及び方法
IPC: H04B10/54
Filed: 2003-05-19
Abstract: 付加／削除ノード（ＯＡＤＮ）は、光ネットワークで信号を伝送するネットワークの光ファイバを有する。ネットワークドロップスプリッタは、ネットワーク光ファイバ及びドロップスプリッタ段に接続され、ドロップスプリッタ段は、ネットワークドロップスプリッタからの光信号を、その信号の複数の複製に受動的に分割する。ＯＡＤＮは、選別された複製を生成するために、少なくとも１つのドロップスプリッタから信号の少なくとも１つの複製を受信する少なくとも１つのフィルタを更に備え、フィルタから選別された複製を受信するよう動作する少なくとも１つのブロードバンド受信機を更に備える。
Patent JP-2005530227-A (JP)
Title: 処方箋の更新要求情報を生成し且つ送信する方法
IPC: G16H20/10
Filed: 2003-06-10
Abstract: 電子ネットワーク（１０６）を介して処方箋更新要求を提供するための方法である。特定のプリスクライバーに対する更新要求情報のために、クライアント（１０４，１１０）からの要求を受信すると、その要求された更新要求情報を含む報告が生成され、クライアント（１０４，１１０）へ送信される。
Patent JP-2005532436-A (JP)
Title: ポリウレタンアイオノマーおよびそれらの調製方法および形成方法
IPC: C08G18/48
Filed: 2003-07-01
Abstract: 本発明は、改善されたポリウレタンアイオノマーおよびそれらを製造する方法に関する。本発明の方法を使用して得られたポリウレタンアイオノマーは、従来の方法により製造されたものよりも物理的特性が改善されたことが分かった。例えば、本発明の方法により生成されたポリウレタンアイオノマーは、それらが、有用で比較的に広い温度範囲および周波数帯域にわたって、温度に対する弾性率（ｌｏｇ １０ Ｅ’として）のプロットにおいて、平坦域を示す。これらのポリウレタンアイオノマーは、−２０℃〜＋７５℃の領域で、５０℃より高い範囲のほぼ温度依存性の弾性率を有する。別の利点には、本発明のポリウレタンアイオノマーが従来調製したポリウレタンアイオノマーよりも光学的に透明であることがある。本発明のさらなる利点には、これらのポリウレタンアイオノマーを製造する合成方法が同等の組成物の公知方法よりもずっと速いことがある。
Patent JP-2005531700-A (JP)
Title: 圧縮装置を備える紡績機用のドラフト機構
IPC: D01H5/72
Filed: 2003-06-30
Abstract: 【課題】圧縮作用が定義されて再生可能に影響され得る可能性を挙げること。 【解決手段】この発明は、ドラフト機構１が圧縮装置７の後方に配置されていて、遅延した繊維帯１８の圧縮が実質的に円形圧縮穴１７から成る一つの穿孔レーンを有する一つの柔軟なエプロン８によって行われ、そのエプロンが固定吸引開口１６を介して圧縮穴の直径よりもより大きな幅の繊維帯の走行方向を横切って案内される紡績機に関する。   そのような圧縮装置の圧縮程度の変更のためには、異なる横伸張ｄ x  を備える或いは圧縮穴１７ x  の異なる相互間隔ａ x  を備えるエプロン８ x  を挙げることが提案されている。達成可能な最大圧縮作用よりもより僅かな圧縮作用を変更可能とするために、より大きい横伸張ｄ x  を備える及び／又は圧縮穴１７ x  のより大きな相互間隔ａ x  を備えるエプロン８ x  が装入され得る。
Patent JP-2006515269-A (JP)
Title: 病原性／感染性タンパク質などのタンパク質においてコンホメーション転移を誘発させる方法
IPC: C07K14/47
Filed: 2003-07-03
Abstract: 本発明は、タンパク質においてコンホメーション転移を誘発させるためのin vitroの方法であって、前記コンホメーション転移によりβ-シート二次構造の含有量の増加がもたらされ、a)転換緩衝液を提供するステップと、b)負に帯電した脂質を含む層状脂質構造の溶液を転換緩衝液に加えるステップと、c)転換緩衝液にタンパク質分子を加えるステップと、d)転換緩衝液、加えた脂質およびタンパク質分子から試料混合物を形成するステップと、e)試料混合物において転換温度を確立するステップと、f)ステップd)の試料混合物をステップe)による転換温度に、コンホメーションが転移したタンパク質が形成されるのに十分な時間曝露させるステップとを含む方法に関する。この方法により層状脂質性構造とコンホメーションが転移したタンパク質との水溶性の複合体が形成され、コンホメーションが転移したタンパク質はオリゴマーβ-シート中間構造である。アミロイド形成的凝集体は、層状脂質構造を能動的に破壊することによって層状脂質性構造とオリゴマーβ-シート中間構造との水溶性の複合体から生成され得る。このようなタンパク質は、伝播性海綿様脳症(TSE)、アルツハイマー病、多発性硬化症、およびパーキンソン病などの神経変性疾患に関与しているかもしれない。本発明の開示は、たとえばPrPCからPrPScへの転換の様々な態様を開拓するため、ならびに新しい診断的なTSE試験およびヒトにおけるクロイツフェルト-ヤコブ病などのTSEに対する潜在的な治療または予防を開発するための、本方法によって生成したタンパク質の使用を含む。
Patent JP-2005538196-A (JP)
Title: アニオン分子の分散性を高めるためにアニオン分子を基材に組み込む方法
IPC: C09K23/00
Filed: 2003-07-18
Abstract: 本発明は、一般に、主題のアニオン分子Aを、(A)大表面積を有するカチオン修飾した基材([S - S - W - ]Q + Q + )の表面に反応させることによって、主題のアニオン分子の分散性を高める方法を提供する。さらに本発明は、それによって得られる、主題のアニオン分子がカチオン修飾した大表面積基材の表面に組み込まれた組成物を提供し、得られるアニオン/カチオン修飾基材組成物(アニオン/有機粘土組成物など)は、目標の適用系において、同じ適用系における主題のアニオン分子単独よりも高い分散性を示す。本発明の方法は、主題のアニオン分子を有機粘土などのカチオン修飾した大面積基材に組み込むことによって、その水溶性を実質上低下させる働きをする。
Patent JP-2005534585-A (JP)
Title: 扁平な発送物のための箱状の容器
IPC: B65D25/06
Filed: 2003-07-24
Abstract: 本発明は、直立位置の扁平な発送物のための箱状の容器であって、上方で開かれた容器から取外し可能なスタック支持体（１０）と、底部（６）と、２つの狭い端面壁（１）と、２つの側方の長手方向壁（２）とが設けられており、発送物の大きい平坦な側が、前記端面壁（１）の方へ配向されている。側方の長手方向壁（２）の内側が、規則的な間隔をおいて、底部（６）に対して垂直方向に、真っ直ぐな延びを有する長く延びた、上方に開かれた切欠き（３）を有しており、該切欠き（３）が、側方の長手方向壁（２）の長手方向では容器内室へのスリット状の開口よりも幅広になっている。スタック支持体（１０）が、両方の側端に成形エレメント（１３）を有しており、これらの成形エレメント（１３）は、形状接続的な接続により、スリット状の開口を貫通して、長く延びた切欠き（３）内を、底部（６）に対して垂直方向にのみ摺動可能である。
Patent JP-2006500016-A (JP)
IPC: G01N/
Filed: 2003-07-30
Abstract: The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.
Patent JP-2006500403-A (JP)
IPC: C07D211/60
Filed: 2003-09-10
Abstract: 1-(Substituted alkyl or propargyl)-4-((3-(6-alkoxy-3-chloro-quinolin-4-yl)-propyl)-piperidine-3-carboxylic acid, -3-acetic acid or -3-methanol derivatives (I) are new. Quinoline derivatives of formula (I) (including isomers, enantiomers and diastereomers and their mixtures) and their salts are new.  R1a = H, halogen, OH, amino, mono- or dialkylamino, hydroxyamino, alkoxyamino or alkyl-(alkoxy)-amino; R1b = H; or R1a + R1b = O; R2 = COOH, COOMe or CH2OH; R3 = (a) 1-6C alkyl substituted by -S-Ph', S-Cyc or S-Het or (b) propargyl substituted by Ph', Cyc or Het; Ph' = phenyl (optionally substituted by 1-4 of halo, OH, alkyl, alkoxy, CF3, OCF3, COOH, alkoxycarbonyl, CN or NH2); Cyc = 3-7C cycloalkyl (optionally substituted by one or more halo or CF3); Het = 5- or 6-membered heteroaryl containing 1-4 of N, O and/or S as heteroatoms (optionally substituted by one or more of halo, OH, alkyl, alkoxy, CF3, OCF3, COOH, alkoxycarbonyl, CN or NH2); and R4 = 1-6C alkyl, (2-6C) alkenyl-CH2, (2-6C) alkynyl-CH2, 3-8C cycloalkyl or (3-8C) cycloalkyl-alkyl. Independent claims are included for: (1) the preparation of (I); and  (2) new piperidine derivative intermediates of formulae (II), (A), (IV), (VI), (XI) and (B). R'1a = H or OH; R1b = H; or R'1a + R1b = O; R'2 = protected COOH or protected -CH2COOH; R5 = H or alkyl; O or keto-protecting group; Rz = amino-protecting group; R''2 = protected COOH; R'' = alkyl; Q1 + Q2 = =CH-R''2 or O; Q3 = H; or Q1 = R'2; Q2 = H; and Q3 = H, OCOCOOR'' or OH.