Patent SG-11201807426W-A (SG)
Title: Immunomodulators
Inventor: ALLEN MARTIN PATRICK
IPC: G01N33/574
Filed: 2017-03-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111101101111111111101111101111011111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...,/ WO 2017/151830 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agents: MINGO, Pamela A. et al.; Bristol-Myers Squibb C07K 7/08 (2006.01) GO1N 33/574 (2006.01) C07K 7/56 (2006.01) A61K 39/39 (2006.01) Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/020304 kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: 2 March 2017 (02.03.2017) BZ, DO, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, KP, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: 62/303,673 4 March 2016 (04.03.2016) US NI, RU, TH, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, ZA, ZM, ZW. New Jersey 08543 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: ALLEN, Martin Patrick; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, GM, TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, _ Princeton, New Jersey 08543 (US). GILLIS, Eric P.; c/o Bristol-Myers Squibb Company, 5 Research Parkway, TJ, DK, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — _ Wallingford, Connecticut 06492 (US). LANGLEY, David R.; c/o Bristol-Myers Squibb Company, 5 Research Park- way, Wallingford, Connecticut 06492 (US). MILLER, Michael Matthew; c/o Bristol-Myers Squibb Company, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Route 206 and Province Line Road, Princeton, New Jersey Declarations under Rule 4.17: = 08543 (US). MULL, Eric; c/o Bristol-Myers Squibb Com- — as to applicant's entitlement to apply for and be granted a pany, 5 Research Parkway, Wallingford, Connecticut patent (Rule 4.17(ii)) M 06492 (US). SUN, Li-Qiang; c/o Bristol-Myers Squibb as to the appli'cant's entitlement to claim the priority of the — Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). YEUNG, Kap-Sun; c/o Bristol-Myers Squibb earlier application (Rule 4.17(iii)) = Company, 5 Research Parkway, Wallingford, Connecticut — of inventorship (Rule 4.17(iv)) 06492 (US). GRANT-YOUNG, Katharine A.; 9 North- Published: = wood Road, Madison, Connecticut 06443 (US). MEAN- WELL, Nicholas A.; c/o Bristol-Myers Squibb Company, — with international search report (Art. 21(3)) = 5 Research Parkway, Wallingford, Connecticut 06492 _ with sequence listing part of description (Rule 5.2(a)) (US). SCOLA, Paul Michael; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut = 06492 (US). = = Il © M GC 11 kf) 11 IN 11 © ei (54) Title: IMMUNOMODULATORS C ) ..,.. (57) : The present disclosure provides novel macrocyclic compounds which inhibit the PD-1/PD-L1 and PD-Ll/CD80 pro - .,. tein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.