baber/WOPTO huggingface dataset:
Patent WO-2022217086-A1 (WO)
Title: Photocleavable guide rnas and methods of use thereof
Inventor: HAZELBAKER DANE
IPC: C12N15/11
Filed: 2022-04-08
Abstract: Provided herein are photocleavable guide RNAs (gRNAs) comprising a targeting domain, a CRISPR RNA (crRNA) sequence for a CRISPR/Cas nuclease, and a at least one photocleavable moiety. Also provided herein are methods involving contacting a photocleavable gRNA and a CRISPR/Cas nuclease to form a CRISPR system. Also provided herein are methods involving providing a cell and contacting the photocleavable gRNA and a CRISPR/Cas nuclease, thus forming a ribonucleoprotein complex that binds to a target site sequence in the genome of the cell.
Patent WO-2022240763-A1 (WO)
Inventor: NEWMAN MARC
IPC: D04H3/033
Filed: 2022-05-09
Abstract: A system having a first polymer source and a spin beam in fluid communication with the first polymer source is provided. The spin beam includes a spinneret assembly having filament nozzles configured and arranged to extrude a plurality of filaments of a first polymer. A gas distribution plate is disposed downstream of the spinneret assembly, and includes a plurality of gas distribution slots that are configured and arranged to receive two or more corresponding filament nozzles of the spinneret assembly therein. A stream of gas is introduced into the plurality of slots to draw and attenuate the filaments extruded by the plurality of filament nozzles. The drawn and attenuated filaments are collected on a collection surface disposed downstream of the gas distribution plate to form a nonwoven fabric. A solid additive, such as pulp fibers may be blended with the filaments prior to collecting the filaments on the collection surface.
Patent WO-2022241310-A1 (WO)
Title: Peptide natriurétique de type b modifié
Inventor: SHANKLEY NIGEL PAUL
IPC: C07H21/04
Filed: 2022-05-16
Abstract: L'invention concerne un peptide natriurétique de type B (BNP) modifié comprenant un polymère lié de manière covalente comprenant des acides aminés, le polymère inhibant la dégradation et/ou l'élimination du BNP chez un sujet, et le BNP modifié conservant une activité vasorelaxante. L'invention concerne également des molécules d'acide nucléique codant pour le BNP modifié décrit ci-dessus, ainsi que des vecteurs comprenant les molécules d'acide nucléique, et des cellules comprenant le vecteur. L'invention concerne également des méthodes de traitement d'un sujet souffrant ou chez qui a été diagnostiquée une maladie, un trouble ou une affection médicale qui peut être traité(e) avec un agent natriurétique, diurétique ou vasorelaxant. Les méthodes consistent à administrer au sujet le BNP modifié ci-dessus. L'invention concerne en outre un procédé de préparation du BNP modifié décrit ci-dessus. L'invention concerne en outre l'utilisation du BNP modifié décrit ci-dessus, de l'acide nucléique décrit ci-dessus, du vecteur décrit ci-dessus et/ou de la cellule décrite ci-dessus pour la fabrication d'un médicament pour le traitement d'une maladie, d'un trouble ou d'une affection médicale qui peut être traité(e) avec un agent natriurétique, diurétique ou vasorelaxant.
Patent WO-2022251402-A1 (WO)
Title: Enzymes transaminases pour la transamination de (1s,5r)-6,8-dioxabicyclo[3.2.1]octan-4-one
Inventor: CAMACHO SOTO KARLA
IPC: C12N9/10
Filed: 2022-05-26
Abstract: La présente invention concerne des enzymes transaminases ayant des propriétés améliorées et sont aptes à réduire le (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one avec une sélectivité élevée. L'invention concerne également des polynucléotides codant pour les enzymes transaminases, des cellules hôtes aptes à exprimer les enzymes transaminases, ainsi que des procédés d'utilisation des enzymes transaminases pour synthétiser une (1S,4R,5R)-6,8-dioxabicyclo[3.2.1]octan-4-amine.
Patent WO-2022251431-A1 (WO)
Title: Method of repositioning a catheter distal tip and related systems
Inventor: MA YIPING
IPC: A61B34/20
Filed: 2022-05-26
Abstract: A catheter assembly may include a catheter adapter, which may include a distal end, a proximal end, and a lumen extending through the distal end and the proximal end of the catheter adapter. The catheter assembly may also include a catheter extending from the distal end of the catheter adapter. The distal tip of the catheter may include a magnetic material. A method of repositioning the distal tip of the catheter may include inserting the distal tip of the catheter into a blood vessel. The method may include attaching another magnetic material to skin, and the distal tip of the catheter may move toward the other magnetic material. At least one of the magnetic material and the other magnetic material may include a magnet. A kit may include the catheter assembly and/or the other magnetic material.
Patent WO-2022251520-A1 (WO)
Title: Acute blockade with delayed neural suppression
Inventor: ACKERMANN DOUGLAS
IPC: A61N1/05
Filed: 2022-05-26
Abstract: Disclosed herein are systems and methods for electrically modulating tissue. Systems can include a current generator; at least one implantable working electrode, the at least one implantable working electrode configured to be in electrical communication with the current generator; at least one indifferent electrode; and a controller configured to signal the current generator to: generate a set of currents with a set of initial polarities to be delivered to the working electrodes; and wherein the at least one indifferent electrode absorbs a bias current which is equal in magnitude and opposite in polarity to a summation of the set of currents.
Patent WO-2022271779-A1 (WO)
Title: Video corruption detection
Inventor: BORBA ANDREW WILLIAM
IPC: G06V10/82
Filed: 2022-06-22
Abstract: Systems, methods, and non-transitory computer-readable media can be configured to train a machine learning model to identify corrupted frames of videos based on training data including video frames exhibiting corruption that is intentionally generated. A frame of a video can be provided to the trained machine learning model. A score indicating a likelihood that the frame of the video exhibits corruption can be determined based on the trained machine learning model.
Patent WO-2023038709-A1 (WO)
Title: Procédés et systèmes de commande de génération automatique de ressources d'énergie renouvelable
Inventor: RAMESH GAUTHAM
IPC: H02J3/00
Filed: 2022-07-15
Abstract: La présente divulgation concerne des systèmes et des procédés pour le fonctionnement d'une centrale électrique comprenant une ressource d'énergie renouvelable et un dispositif de stockage d'énergie. Le procédé peut consister à déterminer, à un premier instant, une prévision de production d'énergie prédite par la centrale électrique sur une période de temps ultérieure au premier instant sur la base d'une prévision pour la période de temps ; détecter un état actuel de charge du dispositif de stockage d'énergie ; calculer une plage de commandes de génération automatique que la centrale électrique est capable de satisfaire pendant la période de temps sur la base de la prévision de production d'énergie prédite et de l'état actuel détecté de charge du dispositif de stockage d'énergie ; et signaler, depuis la centrale électrique à une installation centrale commandant un réseau électrique, la plage de commandes de génération automatique que la centrale électrique est capable de satisfaire pendant la période de temps.
Patent WO-2023009766-A1 (WO)
Inventor: DE FREITAS ADIWARDANA DANIEL
IPC: G06N3/04
Filed: 2022-07-28
Abstract: L'invention concerne des procédés, des systèmes et un appareil, y compris des programmes informatiques codés sur des supports de stockage informatiques, permettant d'évaluer des séquences de sortie candidates au moyen de réseaux neuronaux à modèle de langage. En particulier, un réseau neuronal à modèle de langage auto-régressif est utilisé pour générer une séquence de sortie candidate. Le même réseau neuronal à modèle de langage auto-régressif est utilisé pour évaluer la séquence de sortie candidate afin de déterminer des notes d'évaluation pour au moins un critère. La note d'évaluation est ensuite utilisée pour déterminer s'il faut fournir la séquence de sortie candidate.
Patent WO-2023075885-A1 (WO)
Title: Débruitage de données d'image de profondeur à l'aide de réseaux neuronaux
Inventor: MALLAIYAN SATHIASEELAN MUKHIL AZHAGAN
IPC: G06T5/50
Filed: 2022-08-06
Abstract: Selon l'invention, un dispositif informatique donné à titre d'exemple comprend une machine logique et une machine de stockage contenant des instructions exécutables par la machine logique pour mettre en œuvre un pipeline de traitement d'image de profondeur comprenant un réseau neuronal, le réseau neuronal comprenant une couche de détection de contour. Le réseau neuronal est configuré pour recevoir une entrée d'une image de luminosité active et recevoir une entrée de données réelles et/ou de données imaginaires d'une image de profondeur complexe, l'image de profondeur complexe correspondant à l'image de luminosité active. Le réseau neuronal est en outre configuré pour appliquer, au niveau de la couche de détection de contour, un ou plusieurs processus de convolution à l'image de luminosité active pour identifier un ou plusieurs pixels de contour dans l'image de luminosité active, et débruiter, au niveau d'une seconde couche, les données réelles et/ou les données imaginaires de l'image de profondeur complexe sur la base desdits pixels de contour identifiés.
Patent WO-2023028122-A1 (WO)
Title: Systèmes d'ajustement d'instrument auditif
Inventor: HARIANAWALA JUMANA
IPC: H04R25/00
Filed: 2022-08-24
Abstract: Un procédé d'ajustement d'un instrument auditif consiste à générer des données de formation sur la base de réglages de post-ajustement réalisés sur des paramètres d'une pluralité d'installations auditives et sur la base de profils d'utilisateurs de la pluralité d'instruments auditifs, les réglages de post-ajustement étant réalisés sur les réglages de la pluralité d'instruments auditifs après des utilisations initiales de la pluralité d'installations auditives. Le procédé consiste en outre à former un modèle d'apprentissage machine (ML) sur la base des données de formation pour générer des suggestions d'ajustement initiales. Le procédé consiste également, avant une utilisation initiale d'un instrument auditif courant par un utilisateur actuel, à générer une suggestion d'ajustement initiale correspondant à l'instrument auditif de l'utilisateur actuel par application du modèle ML à une entrée qui comprend un profil de l'utilisateur actuel.
Patent WO-2023091630-A1 (WO)
Title: Enzyme-free isothermal exponential amplification
Inventor: SHIH WILLIAM
IPC: B82Y30/00
Filed: 2022-11-18
Abstract: Provided herein, in some embodiments, are methods, compositions and kits for controlling nucleation and assembly of molecular nanostructures, microstructures and macrostructures.
Patent WO-2023096955-A1 (WO)
Inventor: ROGERS CAMERON
IPC: A61K47/50
Filed: 2022-11-23
Abstract: A quinone-containing polymer includes repeating units of at least one of Formulas (I) to (IV) or a hydrogenated derivative thereof, as defined herein. Methods of manufacturing the quinone-containing polymer are also disclosed. The quinone-containing polymer can be useful in composites, electrode assemblies, electrochemical cells, gas separation systems, energy storage devices, and electrochromic devices.
Patent WO-2023102266-A1 (WO)
Inventor: CRONIN JOHN
IPC: B60L58/40
Filed: 2022-12-05
Abstract: The present invention discloses a modular multi-type power pack charging apparatus. The modular multi-type power pack charging apparatus comprises a plurality of power packs coupled together in series or parallel and connected with charging hardware. A management database is provided and configured to store data related to a type of the plurality of power packs. A charging database is configured to store the charge cycle of each of the plurality of power packs for consumption. A processor with controller hardware and a memory unit coupled to the charging database and the management database to retrieve the performance of the plurality of power packs. The memory unit comprises a plurality of modules to perform charging and discharging of the plurality of power packs. Further, a display interface continuously displays a status of charging and/or discharging of the plurality of power packs.
Patent WO-2023107571-A1 (WO)
Inventor: SELA TAL
IPC: B33Y40/00
Filed: 2022-12-07
Abstract: A three-dimensional (3D) printing system and method for printing a 3D model consisting of a plurality of horizontal layers, the three-dimensional (3D) printing system comprising: a projector capable of emitting light on a two-dimensional (2D) plane; a vat including a photosensitive liquid material directed to solidify in response to an encounter with the emitted light generated by the projector; a building platform directed to be movable perpendicularly to the 2D plane within the vat; and, a polymeric film, consisting of at least one layer, including a first side facing towards the building platform, directed to detachably adhere to the building platform, and a second side facing away from the building platform, directed to interact with a first horizontal layer of the plurality of horizontal layers of the 3D model being printed, so as to fixate the 3D model to the building platform during the printing process.
Patent WO-2023122301-A1 (WO)
Title: Disaster plan implementation for a unified communications network
Inventor: BUNNELL MARK
IPC: H04W76/50
Filed: 2022-12-22
Abstract: A method for rerouting communication in a unified communications network. The method comprises: receiving, at a disaster plan server, a mapping of an original telephony number to a substitute telephony number; storing, at the disaster plan server, the mapping between the original telephony number and the substitute telephone number as part of a disaster plan; receiving, at a disaster plan server, a request to activate the disaster plan; transmitting, from the disaster plan server to a routing server, a message to activate the disaster plan based on receiving the request to activate the disaster plan; revising, at the routing server, routing details to the original telephony number based on the disaster plan; and routing, at a session border controller, a call to the original telephony number to a new destination based on the revised routing details associated with the disaster plan.
Patent WO-2022236288-A1 (WO)
Title: Gastric residence systems comprising buprenorphine and naloxone
Inventor: BHISE NUPURA
IPC: A61K47/10
Filed: 2022-05-04
Abstract: Provided are gastric residence systems comprising at least one co-extruded drug-eluting component comprising a carrier polymer, buprenorphine or a salt thereof, and naloxone or a salt thereof, and a rate-modulating release fdm coating the at least one co-extruded drug¬ eluting component. The gastric residence systems comprising at least one co-extruded drug¬ eluting component are configured to be maintained within a stomach of a human body for at least 48 hours and to release buprenorphine for at least 48 hours, such that the at least one co¬ extruded drug eluting component with the rate-modulating release film is configured to release at least 10 % of the buprenorphine or the salt thereof after the first 24 hours of residence within the stomach and at least 10 % of the naloxone or the salt thereof after the first 24 hours of residence within the stomach.
Patent WO-2022246390-A1 (WO)
Title: Vehicle display device with reduced window glare
Inventor: CHIANG RICHARD
IPC: B60K37/00
Filed: 2022-05-16
Abstract: A vehicle display device comprises: a housing forming an opening to an interior; a first display module positioned in the interior of the housing, the display module including a first louver film that is stacked with a second louver film, wherein respective orientations of the first and second louver films are substantially perpendicular to each other; and a cover glass that covers the opening to the interior of the housing, the cover glass being free floating and having an exposed glass edge; wherein the vehicle display device has a shroud-less design and is configured for positioning within a distance from a vehicle window where the display module is susceptible to generating a reflection in the vehicle window, and wherein at least one of the first and second louver films reduce the reflection.
Patent WO-2023023513-A1 (WO)
Title: Stabilization of oligonucleotide and oligonucleotide-protein complex using alkylated phosphate
Inventor: YAMADA KEN
IPC: A61K31/7115
Filed: 2022-08-16
Abstract: Provided herein are stable, modified oligonucleotides comprising a 5'-alkyl phosphate or derivatives thereof and methods for preparing the same.
Patent WO-2023056246-A1 (WO)
Title: Methods, systems, and computer program product for validating drug product package content using tiered evaluation factors
Inventor: LEWIS RUSSELL F
IPC: G06Q50/10
Filed: 2022-09-27
Abstract: A method includes receiving a drug product package containing one or more drug products therein; evaluating the one or more drug products contained in the drug product package based on a plurality of drug product evaluation factors, the plurality of drug product evaluation factors including an enhanced scrutiny factor; assigning a validation score to the drug product package based on evaluating the one or more drug products contained in the drug product package, a magnitude of the validation score being greater with decreasing patient risk; and validating the drug product package. Validating the drug product package comprises: validating the drug product package based on a first comparison of the magnitude of the validation score with a first threshold responsive to a presence of the enhanced scrutiny factor and a second comparison of the magnitude of the validation score with a second threshold responsive to an absence of the enhanced scrutiny factor, the first threshold being greater than the second threshold; or identifying the drug product package as requiring manual validation responsive to the presence of the enhanced scrutiny factor.
Patent WO-2023108037-A1 (WO)
Title: Techniques for encryption based on perfect secrecy for bounded storage
Inventor: SADJADPOUR HAMID R
IPC: H04L9/30
Filed: 2022-12-08
Abstract: Techniques for secure remote digital storage or transmission of a ciphertext message include determining a maximum storage capacity ℬ of an adversary, determining a security parameter k, wherein 1< < k < < m, and determining a prime number n, such that ℬ < 0.3kn. A current public portion of random string α, comprising n random elements, is read from a public site. A secret key z, wherein z has 2k elements, comprising k additive co-primes of n and k multiplicative co-primes of n is shared with a receiving site. An encryption key X, based on the secret key and the current public string, is determined and applied to a plaintext message M of length ≤ m to encrypt the plaintext message as Y = M ⊕ X, thereby creating the ciphertext message Y, which can be placed on a public forum for receiving by a receiving node.
Patent WO-2023172686-A1 (WO)
Title: Thromboresistant coatings, coated devices, and methods
Inventor: FITZMORRIS KOREN
IPC: A61L27/16
Filed: 2023-03-09
Abstract: Embodiments herein relate to thromboresistant coatings, coated devices, and related methods. In an embodiment, a thromboresistant implantable, partially implantable, or wearable medical device is included having a substrate, a non-fouling basecoat layer, and a lubricious topcoat layer. The non-fouling basecoat layer can include a hydrophilic component and a hydrophobic component. The non-fouling basecoat layer is disposed over the substrate. The lubricious topcoat layer can include a photo-reactive polyvinylpyrrolidone compound and a cross-linking agent. The lubricious topcoat layer can be disposed over the non-fouling basecoat layer. Other embodiments are also included herein.
Patent WO-2023177847-A1 (WO)
Inventor: INBAR MICHAEL
IPC: G02B26/00
Filed: 2023-03-17
Abstract: Systems and devices for correcting a periodic signal includes receiving index light detection data from an optical scanner, determining a bias error of a moveable mirror in optical scanner based on the index light detection data, determining a phase shift error of the moveable mirror based on the index light detection data, and determining an amplitude error of the moveable mirror based on the index light detection data.
Patent WO-2023183565-A1 (WO)
Inventor: SHAW MARK
IPC: E02B3/10
Filed: 2023-03-24
Abstract: A liquid-absorbing, liquid barrier bag comprising a liquid-permeable envelope within which a super-absorbent material in powder or granular form is disposed, the absorbent material being characterized in that it greatly increases in volume upon liquid absorption. The super-absorbent material is adhered to one or more of the inner surfaces of the liquid-permeable envelope such that the desired distribution and pattern is maintained during handling, shipping and activation of the liquid-absorbing. Upon contact with liquid, such as by soaking the bag in water, the super-absorbent material releases from the inner surfaces and swells to create a three-dimensional body suitable for stacking to form a liquid-impermeable barrier wall.
Patent WO-2023192610-A1 (WO)
Inventor: BONDARENKO ALEXEY
IPC: G01V3/30
Filed: 2023-03-31
Abstract: Un système de forage comprend un procédé de détermination d'une orientation d'un train de tiges de forage dans un trou de forage. Un dispositif de mesure de champ de trépan obtient une pluralité de relevés de capteur d'un champ magnétique d'un trépan à l'aide d'un capteur de champ magnétique à une pluralité de positions le long d'une courbe s'étendant autour du trépan le long d'un axe de trépan longitudinal d'un premier emplacement à un second emplacement. Un train de tiges de forage comprend le trépan et un capteur de champ magnétique de fond de trou qui obtient une mesure d'un champ magnétique terrestre local, la mesure étant affectée par le champ magnétique du trépan. Un processeur détermine un moment dipolaire magnétique du trépan à partir de la pluralité de relevés de capteur, calcule une seconde mesure du champ magnétique terrestre local en fond de trou à l'aide du moment dipolaire magnétique du trépan, et détermine l'orientation du train de tiges à partir de la correction calculée de la mesure du champ magnétique terrestre local.
Patent WO-2023229986-A1 (WO)
Title: Method, structure, and composition for filling wide cracks and joints in pavement surfaces
Inventor: DRBOHLAV III JOSEPH
IPC: E01C11/00
Filed: 2023-05-22
Abstract: A method, structure, and composition for repairing wide and/or deep cracks, joints, and other gaps in pavement surfaces using one or a series of layers of a compressible aggregate of uniform size, with each layer of the compressible aggregate having a binder applied thereto which flows downwardly into and binds all or an upper portion of the compressible aggregate.
Patent WO-2023230080-A1 (WO)
Title: Mesure d'acide nitreux par conversion catalytique en oxyde nitrique sur des surfaces de copolymère de fluoropolymère à base de tétrafluoroéthylène sulfoné
Inventor: RAFF JONATHAN DANIEL
IPC: C01B21/24
Filed: 2023-05-23
Abstract: La présente divulgation concerne un système conçu pour convertir de l'acide nitreux gazeux en oxyde nitrique gazeux. Le système comprend un convertisseur catalytique et un analyseur d'oxyde nitrique. Le convertisseur catalytique comprend un tube en polytétrafluoroéthylène et un ou plusieurs tubes concentriques ou substrats à surface élevée constitués d'un copolymère de fluoropolymère à base de tétrafluoroéthylène sulfoné positionné dans le tube en polytétrafluoroéthylène.