baber/WOPTO huggingface dataset:
Patent CN-1260344-A (CN)
Title: 三氯乙酰氯的制备方法
Inventor: JI CHENGJIAN
IPC: C07C53/48
Filed: 1999-08-13
Abstract: 工艺流程短,三废少,产品转化率和收率高,产品质量稳定的三氯乙酰氯的制备方法,按如下步骤进行:(1)将四氯乙烯、氧气、催化剂加入反应釜,升温至180～260℃,待反应釜内温度、压力稳定后,通氧至1.0～6.5MPa,及时移走反应热,然后通氧至反应终了;(2)将反应后料液输入氯化釜,使体系中剩余的四氯乙烯转化为六氯乙烷;(3)将氯化后料液输入精馏釜,分离并收集三氯乙酰氯。本方法适于工业化生产。
Patent CN-1304413-A (CN)
Title: VI型5,6－二氯－2－(异丙基氨基)－1－(β－L－呋喃核糖基)－1H－苯并咪唑
Inventor: CARTER B H
IPC: A61K31/7052
Filed: 1999-04-01
Abstract: 本发明涉及VI型5,6－二氯－2－(异丙基氨基)－1－β－L－呋喃核糖基－1H－苯并咪唑、药用组合物及其医疗用途。
Patent CR-20130594-A (CR)
Title: Monohidrato de derivados de aza-adamantano
Inventor: CHEN SHUANG
IPC: A61K31/439
Filed: 2013-11-14
Abstract: Forma cristalina monohidrato del citrato diácido de (4s)-4-(5-fenil-1,3,4-tiadiazol-2-iloxi)-1-azatriciclo[3.3.1.13,7]decano, composiciones que comprenden dicho compuesto y un proceso para preparar el compuesto.
Patent CR-20210056-A (CR)
Title: New heterocyclic compounds as monoacylglycerol lipase inhibitors
Inventor: KUHN BERND
IPC: C07D498/04
Filed: 2019-08-12
Abstract: <p>The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R<sup>1</sup> and R<sup>2</sup> are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.</p>
Patent CR-20210267-A (CR)
Title: Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
Inventor: ZHENG RUI
IPC: C07D498/08
Filed: 2019-11-26
Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, R<sub>1</sub>, X<sub>1</sub>, X<sub>2</sub>, and X<sub>3 </sub>are described herein.
Patent CR-20220618-A (CR)
Title: Novel ankyrin repeat binding proteins and their uses
Inventor: AMSTUTZ PATRICK
IPC: C07K16/10
Filed: 2021-05-06
Abstract: The present invention relates to recombinant binding proteins comprising one or more designed ankyrin repeat domains with binding specificity for coronavirus spike proteins, nucleic acids encoding such proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such proteins, nucleic acids or pharmaceutical compositions in the treatment of coronavirus diseases, particularly diseases caused by SARS-CoV-2.
Patent EC-SP055832-A (EC)
Inventor: MOORE WILLIAM JAY
IPC: C07D405/04
Filed: 2005-06-02
Abstract: This invention provides a compound of formulae (I) or (II) having the structure or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
Patent EC-SP056263-A (EC)
Title: Anticuerpos humanizados que reconocen el péptido beta amiloideo
Inventor: BASI GURIQ
IPC: G01N33/53
Filed: 2005-12-29
Abstract: La presente invención presenta nuevos reactivos inmunológicos, en particular, reactivos terapéuticos anticuerpos para la prevención y el tratamiento de las enfermedades amiloideogénicas (por ejemplo la enfermedad de Alzheimer). La invención se basa al menos en parte en la identificación y caracterización de un anticuerpo monoclonal, 12A11, que se une específicamente al péptido Aß y es efectivo en la reducción de la carga de placa asociada con los desordenes amiloideogénicos. El análisis estructural y funcional de estos anticuerpos nos lleva al diseño de diversos anticuerpos humanizados para uso profiláctico y/o terapéutico. En particular, la invención presenta la humanización de las regiones variables de este anticuerpo y en consecuencia provee cadenas humanizadas de inmunoglobulina o anticuerpos, inmunoglobulinas o anticuerpos humanizados intactos y fragmentos funcionales de inmunoglobulina o anticuerpos, en particular, los fragmentos que se unen a los antígenos, de los anticuerpos presentados. Los polipéptidos que comprenden las regiones de determinación de complementariedad del anticuerpo monoclonal que se presenta también se explican, así como los reactivos polinucleótidos, los vectores y las células portadoras adecuadas para codificar dichos polipéptidos. Los métodos de tratamiento de las enfermedades o desordenes amiloideogénicos (por ejemplo la enfermedad de Alzheimer), y las composiciones farmacéuticas y conjuntos de ellas a usar en dichas aplicaciones son descritas. También se presentan métodos para identificar residuos con los anticuerpos monoclonales que tratamos y que son importantes para la apropiada función inmunológica y para identificar residuos que son sujetos de substitución en el diseño de anticuerpos humanizados que tengan una afinidad de unión mejorada y/o que tengan una inmunogenicidad reducida, cuando se usan como reactivos terapéuticos. También se presentan anticuerpos (anticuerpos humanizados) que poseen un efecto o función modificadas, y los usos terapéuticos de los mismos.
Patent EC-SP066978-A (EC)
Title: Compuestos amino y su uso como farmacéuticos
Inventor: METCALF BRIAN
IPC: C07D471/10
Filed: 2006-11-08
Abstract: La presente invención se relaciona a los inhibidores del 11-b hidroxil esteroide deshidrogenasa tipo 1, antagonistas del receptor de mineralocorticoides (MR) y las composiciones farmacéuticas de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de varias enfermedades asociadas con la expresión o actividad del 11-b hidroxil esteroide deshidrogenasa tipo 1 y/o enfermedades asociadas con el exceso de aldosterona
Patent EC-SP993002-A (EC)
Title: Nuevas drogas del canal de calcio y sus usos
Inventor: JI YU-HUA
IPC: A61K31/44
Filed: 1999-06-08
Abstract: Se describen detalladamente nuevos compuestos multienlazantes. Los compuestos de esta invención comprenden 2-10 ligantes conectados en forma covalente, y cada uno de los ligantes es capaz de enlazarse a un sitio enlazante de ligante en un canal Ca++, modulando de esta manera las actividades biológicas del mismo.
Patent FI-20000851-A (FI)
Inventor: HOTTINEN ARI
IPC: H04L1/06
Filed: 2000-04-10
Abstract: The invention relates to a radio system and a data mission method. In the method of the invention, a transmitter codes a signal to be transmitted such that at least two non-orthogonal channels are obtained; the transmitter transmits the coded channels via at least two different transmit antenna paths; and a receiver receives the signal. The transmit antenna paths are divided into at least two different groups; and the signals to be transmitted through the different groups are weighted in the transmitter by means of changeable weighting coefficients determined for each group.
Patent FI-20020740-A (FI)
Inventor: AULANKO ESKO
IPC: H02K3/46
Filed: 2002-04-17
Abstract: A stator fastening arrangement for a flat elevator motor may include a stator core, a winding, and a rotor fitted in conjunction with the stator. The stator may be fitted within a mounting part fastened to a motor body. A space provided between the mounting part and the stator may be filled with a thermally conductive filling material for conducting heat away from the stator to the mounting part. The filling material may be provided on one or more axial, outer circumferential surfaces of the stator and in contact with the mounting part so as to fasten the stator to the mounting part.
Patent FI-20051282-A (FI)
Inventor: SJOEHOLM JARMO
IPC: E05B/
Filed: 2005-12-13
Abstract: A locking device (1) for locking to and disconnecting from the floor (5) a movable wall element (2) , door or the like. The locking device (1) functions so that when there is an impact from an outside force on the release pin (13), as when it hits an obstacle, the release pin (13) moves against the springback factor of the second spring (16) from the stop position (III) to the release position (IV) so that the latch pin (9) can move due to the springback factor of the first spring (12) from the release location (II) to the stop location (I) . The locking device is provided with a rocker (17) which is jointed to the frame (6) so that it turns around the horizontal pivot shaft (18) , and said pivot shaft is horizontally at a distance from the first guide. The rocker (17) is provided with a first head (19) which is adapted to co-operate with the upper end (10) of the latch pin (9) in order to move the latch pin when turning the rocker around the pivot shaft, and a second head (20) to which a downwards impacting force (F) can be directed in order to turn the rocker around the pivot shaft (18) in order to lift the latch pin (9) from the stop location (I) to the release location (II) against the springback factor of the first spring (12) .
Patent FI-20061084-A (FI)
Inventor: DEJACO ANDREW P
IPC: G10L19/24
Filed: 2006-12-07
Abstract: A method of adding hangover frames to a plurality of frames encoded by a vocoder, the method comprising: detecting that a predefined number of successive frames has been encoded at a first rate; determining that a next successive frame should be encoded at a second rate that is less than the first rate; and selecting a number of successive hangover frames beginning with the next successive frame to encode at the first rate, the numbering dependent upon an estimate of a background noise level.
Patent FI-20115742-A (FI)
Inventor: SEQUEIRA JOEL A
IPC: A61K31/58
Filed: 2011-07-08
Abstract: Mometasone furoate is used in manufacture of a metered dose inhaler formulation for treatment of asthma, disease ofthe upper or lower airway passages, allergic or non-allergic rhinitis and allergic and/or inflammatory diseases of the lower airway passages and/or lungs.
Patent GB-1014308-A (GB)
IPC: H02G15/18
Abstract: 1,014,308. Tapping cables. SCOTTISH CABLES Ltd. Oct. 9, 1964 [Oct. 11, 1963], No. 40212/63. Heading H2E. [Also in Division H1] In Fig. 1 (not shown) the cross-section of a solid electric conductor designed to facilitate the making of toppings. The small part normally lies in the recess 5 where it is held by latch members 7, 8. To make a connection (Fig. 4, not shown) a window is cut in the insulation giving access to the conductor, the small part is cut through transversely to the cable length and the web 3 joining the small part to the main conductor is cut through. The small part can then be bent away from the main cable and connection made to it by a ferrule 21. The small part can be prised up without braking the transverse cut and connection can then be made to it with a C. ferrule. More than one such small part may be present and they may be situated at the corners of the conductor (Fig. 3, not shown).
Patent GB-1226393-A (GB)
IPC: F02P3/08
Filed: 1968-07-02
Abstract: 1,226,393. Ignition systems. ZENTRALNA RASVOINA LABORATORIA PRI DARJAVNIA KOMITET 2A NAUKA I TECHNITSCHESKI PROGRES. July 2, 1968 [July 10, 1967], No.31590/68. Heading F1B. An ignition system comprises a voltage converter I, a storage capacitor C1 changeable by the converter, a switching thyristor 8 arranged to control discharge of the capacitor C to provide energy for an ignition pulse, a control inlet for connection to a mechanical breaker means 1 to apply a backward voltage between the gate electrode and the common electrode of the thyristor subject to control from the breaker inlet, a coil 10 having an unclosed iron core coupled to the breaker inlet such as to produce when breaker contacts connected across the inlet first open a desired triggering pulse of substantially higher voltage than required for triggering the thyristor and a voltage divider formed of the internal resistance of the thyristor between its gate electrode and common electrode and another resistance in series therewith. The voltage divider is arranged so that the desired triggering pulse and any spurious triggering pulse will be applied to the divider so that a substantial part of the energy of the desired and spurious pulses will be dissipated and ineffective for triggering. A modification is described comprising an individual ignition coil and breaker for each cylinder.
Patent GB-1228087-A (GB)
IPC: F15C1/00
Filed: 1969-09-15
Abstract: 1,228,087. Pneumatic gauges. COMPAGNIE DES COMPTEURS. Sept.15, 1969 [Sept. 27, 1968], No.45443/69. Heading G1M. Positional fluctuations of a beam 10 of a microbalance are detected by measuring variations of the pressure Ps in an annular chamber 4 of a fluid amplifier. Pairs of nozzles 2a, 2b; 3a, 3b are supplied with low-pressure air via a source Pa, capillary constriction 8a, and pressure control device 8b, and the position of a ball 9 attached to the beam 10 causes the pressure Ps to vary in practically a linear manner relative to the ball movement.
Patent GB-1231100-A (GB)
IPC: C04B7/51
Filed: 1968-10-21
Abstract: 1,231,100. Making cement. F. L. SMITH & CO. A/S. 21 Oct., 1969 [21 Oct., 1968], No. 49775/68. Heading C1H. Raw materials containing phosphorus Œ fluorine and yielding a cement clinker with a line saturation factor of at least 0À92 are burned at a temperature to give a free lime content of at least 1% in the clinker which, before grinding, is moistened and stored in 80% humid atmosphere only long enough to hydrate a major part of the lime. Hot gas can be passed through the grinder. Burning temperature is lower by about 100‹ C. from normal.
Patent GB-1231504-A (GB)
IPC: B41J7/00
Filed: 1968-11-06
Abstract: 1,231,504. Keyboards for printers. H. KAFAFIAN. 6 Nov., 1968 [Nov., 16, 1967], No. 52557/68. Heading B6F. [Also in Divisions G4-G6] A control arrangement for operating typewriters or similar machines comprises a number of switches arranged in two groups each group being operable by a different part of the operator's body, e.g. the two hands, the switches of the two groups being interconnected so that when the switch in each group is operated a single output lead is energized. The output lead is connected to a solenoid to operate the corresponding typewriter key. The switches may consist of contacts mounted on clips 10 worn on the fingers and a conductive plate 40. The three finger clips on each hand have two contacts each and the thumb clip has one. The left-hand contacts are connected to the vertical wires 61-67 and the right-hand contacts to the horizontal wires 51-57. Between the wires at each cross-point is connected a solenoid 70 isolated by a diode 69. When one contact from each hand is touched against the plate 40 current from one of the batteries 51a- 57a actuates one of the solenoids. In another arrangement the plate 40 is divided into a left and a right hand portion, a single battery being connected between them. The solenoids may be shunted by spark suppression diodes. Instead of being mounted on separate clips the contacts may be mounted on a glove, the plate 40 being replaced by a contact plate on the thumb. Vertical and horizontal lines are selected by touching finger contacts against the thumb plate. The contacts may be replaced by pressure actuated switches operated simply by pressing the finger against a hard surface. In another form separate left and right hand keyboards are provided.
Patent GB-1233656-A (GB)
IPC: F28F21/08
Filed: 1969-07-14
Abstract: 1,233,656. Radiators. F. DEL BLANCO LOMBAS. 14 July, 1969 [12 July, 1968], No. 35308/69. Heading F4S. In a convector-radiator comprising a plurality of sections connected together in sealed relationship, each intermediate section, which is in the form of an elongate plate 1, has a channel 14, 15 extending lengthwise along each side. The rims of the channels are formed with cooperating lips (16, 17, Fig. 4) between which fit sealing gaskets 28 such as rubber O-rings. Adjacent sections are compressed and held tightly together by tie rods 29 carrying nuts 30 and rectangular washers 31. The end sections have annular bosses 2 into which fit hot water inlet and outlet pipes 26, 27. The channels 14, 15 are in fluid communication with each other through apertures A. Fins or ribs 6, 6<SP>1</SP>, 7, 7<SP>1</SP>, 21, 21<SP>1</SP>, 22, 22<SP>1</SP> provided on each side of the plates 1 outside the channels 14, 15 serve to channel the air to be heated.
Patent GB-1233889-A (GB)
IPC: C08L25/06
Filed: 1969-06-06
Abstract: 1,233,889. Polystyrene-containing patterns for shell moulds. TRW Inc. 6 June, 1969, No. 28746/69. Heading B5A. [Also in Division C3] A pattern material for an investment casting process consists of a mixture of 90 to 50 parts by weight of polystyrene and 10 to 50 parts by weight of one or more water-soluble ethylene oxide polymers having an average molecular weight of 100,000 to 2,000,000. The pattern material may be dipped in a ceramic slurry, dusted with particles of a refractory glass composition and conveyed through a drying oven. Such dippings, coatings and dryings may be repeated and, after a final drying, the coated pattern is placed in a steam autoclave to melt away the pattern and provide a shell mould.
Patent GB-1234297-A (GB)
IPC: A61K9/06
Filed: 1968-08-14
Abstract: 1,234,297. Malic acid esters. P. SERVIERE. 14 Aug., 1968 [24 Aug., 1967], No. 38948/68. Heading C2C. [Also in Division A5] Novel esters of malic acid with 1 - phenyl - 1 - propanol; 2 - phenyl - 2 - propanol; 2 - phenyl- 1 - ethanol or 3 - phenyl - 1 - butyne - 3 - ol are prepared by conventional methods, e.g. by direct esterification at a temperature of about 110-200‹ C. The water is eliminated as it is formed and the ester purified by the usual methods. The esters may be the mono- or diesters.
Patent GB-1238930-A (GB)
IPC: B01D9/00
Filed: 1968-12-19
Abstract: 1,238,930. Crystallization apparatus. NEWTON CHAMBERS & CO., Ltd. 15 Jan., 1970 [19 Dec., 1968], No. 60474/68. Addition to 1,206,611. Heading BIG. In a reflux crystallization apparatus comprising a column inside which a helix is arranged to rotate independently of or integrally with a central core and wherein a heater and a cooler are fitted to opposite ends of the column, a heater or cooler is arranged inside the core adjacent the column-mounted cooler. Preferred constructional details are as in the Parent Specification or Specification No. 1,207,591.
Patent GB-1239503-A (GB)
IPC: G03C11/00
Filed: 1969-02-25
Abstract: 1,239,503. Preventing duplication of microfilm images. EASTMAN KODAK CO. Feb. 25, 1969 [March 26, 1968], No. 10030/69. Heading G2C. A light projectable element containing information in the form of microimages has an imformation bearing layer bonded to a light transmitting support, wherein a light transmitting layer is arranged on the information bearing layer opposite the light transmitting support, the support and layer each having a thickness sufficient to impede the production by means of diffuse light of readable contact copies of the information contained in the element, and wherein a light dispersing layer is arranged between the external surfaces of the element on one side of the information bearing layer in such a manner that the production of readable contact copies of the information contained in the element by means of specular light is impeded. The lightdispersing layer may be formed of a transparent layer containing light dispersing particles and said transparent layer may be a bonding layer connecting the other layers of the information bearing element. This bonding layer may connect the information bearing layer with the light transmitting support. The light dispersing layer may be a portion of the light transmitting support containing light scattering particles, and may be a sheet arranged between two other portions of the light transmitting support. The light dispersing layer is preferably 0À01 inches from either external surface of the element and the particles therein preferably have a diameter between 2 and 4 microns at a concentration of 15,000 per sq mm. The light dispersing layer may consist of oil dispersions within a gelatin bonding layer, or may be formed by a roughened surface of the light transmitting support. The information bearing layer is preferably spaced at least 0À01 inches from each of the external surfaces of the element. This invention is described with reference to low reduction type microfilms, but may be used for high reduction type microfilms.
Patent GB-1252717-A (GB)
IPC: C07D331/02
Filed: 1970-02-06
Abstract: 1,252,717. Oxirane and thiirane ether derivatives. GENERAL TIRE & RUBBER CO. 6 Feb., 1970 [28 Feb., 1969], No. 5895/70. Heading C2C. [Also in Division C3] Compounds of the general formula where Z is or in which X is O or S, R is C 2-7  alkylene, R<SP>1</SP> is C 1-8  alkyl, R<SP>11</SP> is C 1-8  alkylene when y is 1 or R<SP>11</SP> is C 2-8  alkylene when y is 2 to 9, are prepared by reacting glycidol, in the presence of a catalytic amount of an alkaline compound, with at least one vinyl-type compound selected from: H 2 C=CHCN, SO 2 -(-CH=CH 2 ) 2 , CH 2 =CHSO 2 R<SP>1</SP>, CO-(-CH=CH 2 ) 2 , CH 2 =CHCOR<SP>1</SP>, HR<SP>111</SP>C=CR<SP>1111</SP>-COOR<SP>1</SP> and HR<SP>111</SP>C=CR<SP>1111</SP>-COO-(R<SP>11</SP>-O)y-COR<SP>1111</SP>C=CR<SP>111</SP>H where R<SP>111</SP> is H or alkyl and R<SP>1111</SP> is H, methyl or ethyl, the maximum total number of C atoms of (R<SP>111</SP> + R<SP>1111</SP>) being 5. The reaction between glycidol and the vinyl-type compound is preferably conducted at 25-150‹ C. in the presence of an alkali metal alkoxide. Amongst numerous examples the following compounds are prepared #-glycidyloxypropionitrile, methyl #-glycidyloxypropionate, bis-(#-epithio-propoxyethyl)sulphone, #-epithiopropoxyethyl methyl ketone, and dipropylene ether glycol bis (#-glycidyloxypropionic acid ester).
Patent GB-1257438-A (GB)
IPC: B30B9/30
Filed: 1970-06-16
Abstract: 1,257,438. Refuse compacting machines. TRANSWORLD COMPACTORS (B.V.I.) Ltd. 16. June, 1970, No. 29246/70. Heading B8C. Refuse placed into the machine through hinged doors 46 and 74 falls into a disposable cardboard box 96 supported within a metal sleeve 78 and is compressed by the downward movement of an hydraulic ram 70. The ram is lowered by a piston and cylinder arrangement 64 on downward movement of a manual control lever 44. Subsequent raising of the lever 44 raises the ram so that the machine is ready to receive further refuse. In the lowered position of the. ram, a plate 106 is supported by stops 110 to prevent further refuse being added through the door 74. The plate 106 is raised by contact with the upper surface of the ram. The door 74 normally engages under tabs 76 on the door 46 so that the two doors move together. The sleeve has a bottom wall 84 and rests on a concrete slab 114 provided with a front roller 116 so that, after a front part 24 of the machine casing has been opened, the sleeve may be drawn forwards by means of a handle 92. Spring loaded legs 120 are lowered to support the sleeve while its front 88 is pivoted open and are then collapsed to tilt the sleeve and aid the removal of the cardboard box 96. A new box is then loaded into the machine and has at least one of its flaps held open by a spring loaded clip 98. Each time refuse isadded to the machine, an electric switch 40 has to be operated to energize the ram mechanism. The switch 40 may be in the form of a spring loaded button which has to be depressed with one hand while the other hand operates the lever 44; thus neither hand can enter the machine while the ram is moving.