Patent SG-11201808709V-A (SG)
Title: T cell receptors
Inventor: TRIBBLE NICHOLAS
IPC: C07K14/705
Filed: 2017-04-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 HO 1111101110101110111111101011101111111011110111111 International Bureau .. .... ..Yejd (10) International Publication Number ..... .....1 (43) International Publication Date WO 2017/174822 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: C07K 14/705 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: PCT/EP2017/058576 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: 10 April 2017 (10.04.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 1606172.3 8 April 2016 (08.04.2016) GB kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: ADAPTIMMUNE LIMITED [GB/GB]; 101 Park Drive, Milton Park, Abingdon Oxfordshire OX14 4RY (GB). (72) Inventors: TRIBBLE, Nicholas; c/o Adaptimmune Lim- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, ited, 101 Park Drive, Milton Park, Abingdon Oxfordshire OX14 4RY (GB). LAWRANCE, William; c/o Adaptim- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). mune Limited, 101 Park Drive, Milton Park, Abingdon Ox- Published: fordshire OX14 4RY (GB). BAGG, Eleanor; c/o Adaptim- mune Limited, 101 Park Drive, Milton Park, Abingdon Ox- - with international search report (Art. 21(3)) — fordshire OX14 4RY (GB). — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of = (74) Agent: BIRTLE, Zoe; 30 Carlton Crescent, Southampton Hampshire S015 2EW (GB). amendments (Rule 48.2(h)) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (81) = = = = = = = = = = = 1-1 ei ei co ii- IN ,-1 (54) Title: T CELL RECEPTORS C 1-1 (57) : The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVY - el DGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity pro - en) files for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells har - 7 19 bouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the 5 invention.