Patent KR-100761414-B1 (KR)
Title: A biomarker for diagonosis of infection of bacillus anthracis and the method of diagonosis using the same
Inventor: CHAI YOUNG GYU
IPC: C12Q1/68
Filed: 2006-05-25
Granted: 2007-10-04
Abstract: A micro-array chip is provided to show the specific increase or decrease of expression in macrophage when a subject is stimulated by toxins providing pathogenicity, thereby being used for rapid diagnosis of the anthracnose. A micro-array chip for diagnosing the infection of Bacillus anthracis includes at least one gene selected from the group consisting of Pacs1(GenBank No. Al503516), Psg21(GenBank No. Ak005540.1), Zfp313(GenBank No. AV216903), Coxcl2(NM_009140.1), Gna14(GenBank No. NM_008137.1), Osm(GenBank No. BB237825), Adk(GenBank No. BB053697), Pim1(GenBank No. Al323550), Arid5b(GenBank No. BB079486), Nr4a3(GenBank No. BE692107), Nr4a2(GenBank No. BB322941), Ppp1r12b(GenBank No. BB521745), Nr4a1(GenBank No. NM_010444.1), Tmepai(GenBank No. AV370981), Mertk(GenBank No. NM_008587.1), Dscr1(GenBank No. AF260717.1), Csf1(GenBank No. NM_007778.1), Gm337(GenBank No. BB442784), Sh3bgrl(GenBank No. BB548587), Dsip1(GenBank No. AF201289.1), Fos(GenBank No. AV026617), Grasp(GenBank No. BB071890), Itpr5(GenBank No. M90087.1), Cbx8(GenBank No. NM_013926.1), Crem(GenBank No. Al467599), Erg3(GenBank No. AV346607), Gpr35(GenBank No. NM_022320.1), Ccrl2(GenBank No. AJ318863.1), Cxcr4(GenBank No. D87747.1), Btg2(GenBank No. BG965405), MGC102419(GenBank No. BB772272), Oplah(GenBank No. AK005822.1), Fosl2(GenBank No. BM245170), Gem(GenBank No. U10551.1), Plekhf1(GenBank No. BC002120.1), Thbd(GenBank No. NM_009378.1), Traf1(GenBank No. BB218245), Cd86(GenBank No. BC013807.1), Pdgfb(GenBank No. NM_011057.1), Skil(GenBank No. U36203.1), Synj2(GenBank No. AK014584.1), Il1b(GenBank No. BC011437.1), Pscd1(GenBank No. AB013464.1), Actb(GenBank No. NM_007393.1), Btbd7(GenBank No. BB199960), Ccl7(GenBank No. AF128193.1), Cd80(GenBank No. BM121947), Cradd(GenBank No. BM234069), Flnb(GenBank No. BM206272), Pdgfa(GenBank No. BB371842), Pscd bp(GenBank No. BB503614), Pwwp2(GenBank No. BB809239), Stk38l(GenBank No. AV257215), Adora2b(GenBank No. BB709140), Cxcl10(GenBank No. NM_021274.1), Gadd45g(GenBank No. AK007410.1), Garnl1(GenBank No. BM244074), Ipo11(GenBank No. AK006967.1), Itga5(GenBank No. AW25495), Opcml(GenBank No. BE650754), Rai14(GenBank No. BB534392), Rbbp6(GenBank No. BC025874.1), Sin3b(GenBank No. L38622.1), Tle1(GenBank No. NM_011599.1), Tnfaip3(GenBank No. NM_009397.1), Tpm1(GenBank No. BM232388), Txndc7(GenBank No. AK005989.1), Zfp36(GenBank No. X14678.1), Dst(GenBank No. BG072223), Tnfsf9(GenBank No. NM_009404.1), Dab2(GenBank No. AK017619.1), Dusp4(GenBank No. AK012530.1), Hmgcs1(GenBank No. AV362707), Maf(GenBank No. AV284857), Cebpd(GenBank No. BB831146), Mnt(GenBank No. U77356.1), Mbd5(GenBank No. AV298746), Bak1(GenBank No. AF402617.1), Lpin1(GenBank No. AK014526.1), Ldlr(GenBank No. BM207320), Nedd9(GenBank No. BB535494), Creb5(GenBank No. Al118522), Ctsb(GenBank No. BG067383), Cd28(GenBank No. NM_007642.1), Cdl12(GenBank No. U50712.1), Ell(GenBank No. BC024894.1), Foxp1(GenBank No. BB021390), Fosl1(GenBank No. NM_010235.1), Il17r(GenBank No. AK010040.1), Mapk7(GenBank No. NM_011841.1), Nfat5(GenBank No. BB432268), Sc4mol(GenBank No. BG070057), Cadps(GenBank No. BE982890), Cdkn1a(GenBank No. NM_007669.1), Dcp1b(GenBank No. BG968708), Fndc3(GenBank No. BB518323), Gadd45a(GenBank No. NM_007836.1), Idb1(GenBank No. U43884.1), Itsn1(GenBank No. BG074656), Myo9b(GenBank No. BM121122), Npm3(GenBank No. BB811478), Pde4a(GenBank No. NM_019798.2), Rtn4(GenBank No. BB648600), Rb bp6(GenBank No. BC016578.1), Arhgap25(GenBank No. BM241218), Slc12a6(GenBank No. BB152956) and Stk17b(GenBank No. BG064688). The kit for diagnosing the infection of Bacillus anthracis comprises the micro-array chip.