baber/WOPTO huggingface dataset:
Patent CA-2772169-A1 (CA)
Inventor: IWEMA BAKKER WOUTER I
IPC: C07D279/12
Filed: 2010-08-27
Abstract: The present invention relates to (thio)morpholine derivatives of the formula (I), wherein R1 is selected from cyano, (2-4C)alkynyl, (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenyl, (6-8C)bicycloalkyl, (8-10C)bicyclic group, each optionally substituted with (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkyloptionally substituted with one or more fluoro atoms, (2-4C)alkynyl, (1-4C)alkoxy optionally substituted with one or more fluoro atoms,amino, di(1-4C)alkylamino, -SO2-(1-4C)alkyl, -CO-(1-4C)alkyl, -CO-O-(1-4C)alkyl, -NH-CO-(1-4C)alkyl and (3-6C)cycloalkyl, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each optionally substituted with (1-4C)alkyl, monocyclic heterocycle optionally substituted with halogen, (1-4C)alkyl or with phenyl optionally substituted with (1-4C)alkyl, and bicyclic heterocycle optionally substituted with (1-4C)alkyl; A is selected from -CO-O-, -O-CO-, -NH-CO-, -CO-NH, -C=C-, -CCH3-O- and the linking group Y-(CH2)n-X- wherein Y is attached to R1 and selected from a bond, -O-, -S-, -SO-, -SO2-, -CH2-O-, -CO-, -O-CO-, -CO-O-, -CO-NH-, -NH-CO-, -C=C-and -C=C-; n is an integer from 1 to 10; and X is attached to the phenylene / pyridyl group and selected from a bond, -O-, -S-, -SO-, -SO2 -, -NH, -CO-, -C=C-and -C=C-; ring structure B optionally contains one nitrogen atom; R2 is H, (1-4C)alkyl optionally substituted with one or more fluoro atoms, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, or halogen; and R3 is (1-4C)alkylene-R5 wherein the alkylene group may be substituted with (CH2)2 to form a cyclopropyl moiety or one or two halogen atoms, or R3 is is (3-6C)cycloalkylene-R5 or -CO-CH2-R5, wherein R5 is -OH, -PO3H2, -OPO3H2, -COOH, -COO(1-4C)alkyl or tetrazol-5-yl; R4 is H or (1-4C)alkyl; R6 is one or more substituents independently selected from H, (1-4C)alkyl or oxo; W is -O-, -S-, -SO- or -SO2-; or a pharmaceutically acceptable salt, a solvate or hydrate thereof; with the proviso that the derivative of formula (I) is not 2-(4-ethylphenyl)-4-morpholinoethanol or 4-[4-(2-hydroxyethyl)-2-morpholinyl]benzeneacetonitrile or a pharmaceutically acceptable salt, a solvate or hydrate thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of S1P receptor mediated diseases and conditions.
Patent CA-2772284-A1 (CA)
Title: [1,4]-benzodiazepines as vasopressin v2 receptor antagonists
Inventor: MEULEMANS ANN
IPC: C07D243/14
Filed: 2010-09-23
Abstract: The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.
Patent CA-2772989-A1 (CA)
Title: Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer
Inventor: MILLER-MOSLIN KAREN
IPC: C07C311/20
Filed: 2010-09-08
Abstract: The present invention includes novel compound and methods of treating a disease or disorder by antagonizing Bcl-2 family proteins, particularly compounds of Formula (I) or pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Bcl-2 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula (I) and pharmaceutically acceptable salts thereof.
Patent CA-2775372-A1 (CA)
Inventor: REYNOLD DAVID L
IPC: A61J1/20
Filed: 2010-10-27
Abstract: La présente invention concerne un système de transfert de médicaments, qui comprend les éléments suivants : une douille de flacon (14) ; un boîtier (18), pourvu d'une première et d'une seconde extrémité ouverte, la première extrémité ouverte étant raccordée de manière amovible à la douille de flacon (14) ; une embase d'aiguille (16) montée dans le boîtier (18) ; une aiguille dotée d'une première et d'une seconde extrémité de perçage (58, 70), montée dans ladite embase d'aiguille (16) ; un flacon (12) pourvu d'un col (32) et d'un corps (30), ledit flacon (12) étant inséré dans la douille de flacon (14) et y étant retenu de manière non amovible ; une cartouche (20) dotée d'un piston (24) fermant hermétiquement une extrémité ouverte de celle-ci et d'un septum (82) situé à l'extrémité opposée de la cartouche (20) ; et une capsule d'activation (22) qui entraîne la pénétration de l'aiguille à travers un septum (34) du flacon (12) et à travers le septum (82) de la cartouche (20) pour permettre le transfert de composants entre les deux récipients.
Patent CA-2775392-A1 (CA)
Inventor: ASANO TAKUJI
IPC: A61F2/06
Filed: 2011-06-13
Abstract: Disclosed is an artificial blood vessel (10) which comprises: a shaft part (12) which has a blood vessel connected to each end; access branch parts (14, 16) which branch out from the shaft part; and a shunt branch part (18). A solid cylindrical access port (20) is disposed in the access branch parts (14, 16) and shuts off these branch parts. The access port (20) has a solid central part (22) and a tube-shaped peripheral part (24) disposed such as to enclose the central part (22). The peripheral part (24) is harder than the central part (22) such that a needle will not move from inside the center part (22). As a result, it is possible to easily carry out the puncturing involved in a treatment method where a blood vessel is frequently punctured.
Patent CA-2775821-A1 (CA)
Inventor: SCHNEIDER PETER
IPC: A61L27/54
Filed: 2010-06-11
Abstract: A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
Patent CA-2776138-A1 (CA)
Title: Flywheel-based energy storage on a heave-compensating drawworks
Inventor: WILLIAMS KEVIN R
IPC: H02K7/02
Filed: 2010-09-02
Abstract: A system (30) for managing energy consumption in a heave-compensating drawworks includes a power supply (40), a winch drum (28) connected to the power supply (40) so as to receive power from the power supply, a flywheel (52) connected to the winch drum (28) and to the power supply (40), and a controller (42) connected to the power supply and to the winch drum for passing energy to and from the flywheel during an operation of the winch drum. The flywheel (52) includes a disk rotatably coupled to an AC motor (54). The power supply (40) includes a first pair of AC motors (64, 66) operatively connected on one side of the winch drum (28) and a second pair of AC motors (68, 70) operatively connected on an opposite side of the winch drum.
Patent CA-2777818-A1 (CA)
Inventor: ZHENG GUODONG
IPC: C09K21/02
Filed: 2012-05-22
Abstract: Des produits en fibre de verre offrant une résistance accrue aux flammes sont décrits. Les produits peuvent comprendre un isolant thermique renfermant de la fibre de verre qui comprend une pluralité de fibres de verre qui sont au moins partiellement revêtues dun retardateur de flamme renfermant de la vermiculite. Les produits peuvent également comprendre des composites en fibre de verre qui comportent environ 50 % par poids à environ 98 % par poids de fibres de verre, environ 2 % par poids à environ 50 % par poids dun liant et un retardateur de flamme qui renferme de la vermiculite. Des méthodes sont également décrites servant à la fabrication de produits de fibre de verre ayant une résistance accrue aux flammes. Ces méthodes peuvent comprendre les étapes de mise en contact des fibres de verre ou du composite en fibres de verre avec un mélange retardateur de flammes qui renferme de la vermiculite.
Patent CA-2777993-A1 (CA)
Inventor: EHRMAN GEOFFREY N
IPC: B65D85/67
Filed: 2012-05-23
Abstract: A drainage-promoting wrap includes an elongate strip of weather-resistive membrane storable in a spiral roll and a series of separate, spaced-apart, spacers elements bonded to a face of the weather-resistive membrane. The spacer elements project from the face to a predetermined height and are formed of a hot-melt material applied to the membrane. A series of self-sealing fastener tabs can also be formed on the face of the membrane. Wall and roof assemblies utilizing the wrap are also provided.
Patent CA-2778141-A1 (CA)
Title: Method and apparatus for treatment of wastewater
Inventor: SMITH WILLIAM G
IPC: C02F3/30
Filed: 2007-09-24
Abstract: A method for improving a wastewater treating process employing one of activated sludge or a sequencing batch reactor comprising the steps of introducing into one or more of the reactor tanks of an activated sludge treatment process or a sequencing batch reactor a quantity of synthetic high surface area biological growth support media together with a separate natural zeolitic material being one of clinoptilolite, mordenite, chabazite or phillipsite and one or more separate cultured bacterial agents to effect one or more of an increased production of extra cellular polysaccharides for better liquid solid separation, removal of ammonia, denitrification. COD and BOD removal, reduction of surfactant interference with liquid solid separation, provide a balanced nutrient formulation in the wastewater, phosphate removal and odor removal.
Patent CA-2778322-A1 (CA)
Inventor: HATIER JEAN-DENIS
IPC: G05D23/19
Filed: 2012-05-23
Abstract: The method is for operating a remotely-controlled switching device of an energy management system. The switching device is mounted in series on a local electrically powered circuit on which are also mounted in series a load and an electronic thermostat. The method includes generating a first pulsed signal for controlling the switching device, the switching device opening and closing the circuit in response to the first signal. The circuit is opened to prevent the load from operating and is closed when operation of the load is allowed. The method includes generating a second pulsed signal for controlling the switching device at least when the circuit is opened by the switching device in response to the first signal. The second signal causes the switching device to temporarily close the opened circuit at given intervals for keeping an internal circuitry of the thermostat energized while still substantially preventing the load from operating.
Patent CA-2778820-A1 (CA)
Inventor: MORIN JEREMY
IPC: B32B27/00
Filed: 2010-10-28
Abstract: A method of making a one-way gas release valve (11) for releasing gas pressure from within a coffee container comprises pre-oiling a relatively narrow dry strap (13) of flexible material and laminating the pre-oiled dry strap between relatively wide ribbons of base (18) and cover material (12) with the dry strap (13) overlying spaced vent patterns in the base material (18). Alternatively, the base material may be pre-oiled or both the base material and the dry strap may be pre-oiled. The dry strap (13) and base (18) may be made of PET and the cover (12) may be made of mPET. Gas release valves (11) are then die cut from the resulting web with each valve containing a vent pattern. Pre-oiling of the dry strap (13) and/or the base (18) can be accomplished through a roll metered process to insure that the oil (17) is applied in precise amounts and with consistent thickness and coverage. Since the oil (17) is applied during fabrication of the gas release valves (11), the vent patterns in the base (18) can be configured to function also as a filter to prevent coffee grinds (27) from migrating into the valve (11).
Patent CA-2779504-A1 (CA)
Title: Wireless gaming environment
Inventor: ROWE RICHARD E
IPC: A63F13/12
Filed: 2001-04-06
Abstract: A disclosed hand-held device provides a game service system having a wire-less communication interface, a display screen and a microprocessor which generates a number of game service interfaces on the display screen. The hand-held device may input ticket voucher information and communicate with a remote transaction server such that a ticket voucher may be validated. Additionally, the hand-held device may be used to provide a variety of gaming services using different game service interfaces provided on the device. These hand-held devices may be checked out by a game service representative in a secure manner such that the game service representative may roam a game playing area and provide various game services to game players in the game playing area using the hand-held device. These game services may include ticket validation, a prize validation, food services, accommodation services or a gaming operations services.
Patent CA-2781640-A1 (CA)
Title: Control gates
Inventor: AUGHTON DAVID
IPC: E02B7/28
Filed: 2001-08-21
Abstract: The invention provides a control gate (10) adapted to be installed across a channel (12) for liquids. The control gate (10) has a barrier member (76) that is pivotally mounted at or adjacent the base (20) of a flow channel (12). A drive means (34) cooperates with cables (56,58) extending along the barrier member (76) to allow raising and lowering of barrier member (76) to regulate flow of liquid through the control gate (10).
Patent CA-2784059-A1 (CA)
Inventor: LANGLEY CHRISTOPHER NIGEL
IPC: G06K7/10
Filed: 2011-01-21
Abstract: An identifier (50) for a medicament reservoir (20) is provided, wherein the identifier (50) comprises a malleable sheet (164) of material. The sheet (164) of material comprises a top surface (54, 104) and a bottom surface (56, 112). The bottom surface (56, 112) may be used to apply the identifier (50) to a surface of the medicament reservoir (20). A first three-dimensional feature (60) is attached to the sheet (164) of material. The three-dimensional feature (60) may be representative of a medicament (26) contained in the reservoir (20) and may further comprise an alignment feature (224, 228). In addition, the three-dimensional feature (60) may be coded for a particular drug delivery device (10). Such drug delivery devices (10) could comprise pen type drug delivery devices.
Patent CA-2784124-A1 (CA)
Title: Pet waste removal device
Inventor: ORUBOR LAWRENCE
IPC: A47L11/14
Filed: 2010-12-14
Abstract: A pet waste removal device including an elongated hand held boom having an open bottom shield disposed at a bottom end of the boom for positioning over a pile of animal waste. A motor driven agitator is disposed within the shield and driven by a motor to rotate between a counterclockwise and a clockwise rotation to mechanically break up pet waste. Fluid jet nozzles are supplied water via a garden hose connection and are arranged to direct water jets into the shield to wash away the pet waste as it is broken up by the agitator. A chemical dispenser for dispensing a chemical solution can also be provided.
Patent CA-2784939-A1 (CA)
Title: Procede et dispositif de determination d' un risque de rejet
Inventor: FOUCHER YOHANN
IPC: G16Z99/00
Filed: 2010-12-15
Abstract: L'invention concerne, un procédé de détermination d'un risque de rejetdéfinitif d'un greffon après transplantation sur un receveur, caractérisé en ce qu'il comprend les étapes suivantes: (a) introduire de caractéristiques physiologiques/cliniques du receveur et du donneur à l'aide d'une interface d'entrée dans une unité de calcul, lesdites caractéristiques comprenant: -le genre du receveur, -le taux de créatinine du donneur du greffon au moment du prélèvement, -l'âge du receveur du moment de la transplantation, -le nombre de transplantations rénales antérieures que le receveur a reçues, -un taux de créatinine du receveurmesuré à deux au moins un moment déterminé après la transplantation, -un taux de protéinurie du receveurmesuré à un moment déterminé après la transplantation, -l'existence d'un épisode de rejet définitif lors de la première année de la transplantation, (b) déterminer des paramètres à partir desdites caractéristiques, (c) combiner lesdits paramètres afin d'obtenir un score de risque de rejet définitif du greffon, et (d) analyser le dit score de risque afin de déterminer un risque de rejet définitif d'un greffon.
Patent CA-2786258-A1 (CA)
Inventor: LANIER GREGORY R JR
IPC: G16H20/17
Filed: 2010-12-29
Abstract: A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an externa! infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from {lie reservoir and providing the quantity of infusible fluid to the volume sensor assembly- The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system also includes at least one optical sensor assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir. The fluid delivery system further includes a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set. The at least one optica! sensor assembly is configured to sense the movement of the pump assembly.
Patent CA-2786349-A1 (CA)
Inventor: STEINER GEORG ROBERT GUSTAV
IPC: G06F1/16
Filed: 2012-08-16
Abstract: An electronic device includes an interlocking mechanism for fixing a keypad to a housing of the device. The housing is coupled with the keypad such that the keys may extend to the edges of the electronic device and the edge keys are secured against being removed from the keypad. The edge keys may include a hook or locking mechanism coupled with the housing to prevent uprooting of the edge keys. Another set of hooks or lockings connect the housing with the keypad to prevent bulging of the keypad and to limit lateral movement between the keys or the keypad with the housing.
Patent CA-2787610-A1 (CA)
Title: Gaming system, gaming device, and method providing a game with multi-component symbols and awards based on common components
Inventor: NICELY MARK C
IPC: G07F17/34
Filed: 2012-08-24
Abstract: The gaming system receives a wager from a player for a play of a game including a plurality of multi-component symbols. Each of the multi-component symbols includes a plurality of symbol component locations. A plurality of the multi-component symbols include at least one of the symbol components in at least one of the symbol component locations. The gaming system randomly generates and displays a plurality of the multi-component symbols. The gaming system determines, for a first one of a designated number of the displayed multi-component symbols, a quantity of symbol component locations of the first one of the displayed multi-component symbols that display one of the symbol components and that correspond to a symbol component location of each of the other displayed multi-component symbols of the designated number of the displayed multi-component symbols that each display one of the symbol components. Any awards are determined based on the determined quantity.
Patent CA-2790170-A1 (CA)
Inventor: SWIFT ROBERT ALAN
IPC: A61K31/34
Filed: 2011-05-17
Abstract: The invention provides a method for treating hypoxia caused by high altitude by administering to a subject a compound that reduces the ?50 of hemoglobin for oxygen.
Patent CA-2791219-A1 (CA)
Inventor: VERMEIREN WALTER
IPC: C07C11/09
Filed: 2011-03-15
Abstract: The present invention relates to a process for the production of propylene in which in a first step isobutanol is subjected to a simultaneous dehydration and skeletal isomerisation to make substantially corresponding olefins, having the same number of carbons and consisting essentially of a mixture of n-butenes and iso-butene and in a second step n-butenes are subjected to methathesis, said process comprising : a) introducing in a reactor a stream (A) comprising isobutanol, optionally water, optionally an inert component, b) contacting said stream with a catalyst in said reactor at conditions effective to dehydrate and skeletal isomerise at least a portion of the isobutanol to make a mixture of n-butenes and iso-butene, c) recovering from said reactor a stream (B), removing water, the inert component if any and unconverted isobutanol if any to get a mixture of n-butenes and iso-butene, d) fractionating said mixture to produce a n-butenes stream (N) and to remove the essential part of isobutene optionally recycled with stream (A) to the dehydration/isomerization reactor of step b), e) sending the stream (N) to a methathesis reactor and contacting stream (N) with a catalyst in said methathesis reactor, optionally in the presence of ethylene, at conditions effective to produce propylene, f) recovering from said methathesis reactor a stream (P) comprising essentialy propylene, unreacted n-butenes, heavies, optionally unreacted ethylene, g) fractionating stream (P) to recover propylene and optionally recycling unreacted n-butenes and unreacted ethylene to the methathesis reactor.
Patent CA-2798609-A1 (CA)
Title: Mouth cleaning device and head portion of a mouth cleaning device
Inventor: SCHAEFER NORBERT
IPC: A61N1/32
Filed: 2011-05-03
Abstract: A head portion for a mouth cleaning device is disclosed. The head portion includes an electrical connecting element; cleaning elements for cleaning teeth; and a tongue cleaning electrode for enabling a current flow into a user's tongue during use. The cleaning elements and the tongue cleaning electrode are arranged on substantially opposing sides of the head portion. The electrical connecting element on the head portion is electrically coupled to the tongue cleaning electrode for establishing an electrical connection with a corresponding electrical connecting element located at a handle portion in a connected state.
Patent CA-2798616-A1 (CA)
Inventor: BANCHEREAU JACQUES F
IPC: A61K38/16
Filed: 2011-05-04
Abstract: Immunostimulatory compositions and methods comprising an ITIM motif-containing DC immunoreceptor (DCIR) to mediate potent crosspresentation are described herein. The inventors evaluated human CD8+ T cell responses generated by targeting antigens to dendritic cells (DCs) through various lectin receptors. A single exposure to a low dose of anti-DCIR-antigen conjugate initiated antigen-specific CD8+ T cell immunity by all human DC subsets including ex vivo generated DCs, skin-isolated Langerhans cells and blood mDCs and pDCs. Enhanced specific CD8+ T cell responses were observed when antigens like, FluMP, MART-1, viral (HIV gag), etc. were delivered to the DCs via DCIR, compared to those induced by a free antigen, or antigen conjugated to a control mAb or delivered via DC-SIGN, another lectin receptor. Addition of Toll-like receptor (TLR) 7/8-agonist enhanced DCIR-mediated crosspresentation as well as crosspriming. Thus, antigen targeting via the human DCIR receptor allows activation of specific CD8+ T cell immunity.