baber/WOPTO huggingface dataset:
Patent SK-278810-B6 (SK)
Title: The derivative of 2-aminothiazole or 2-aminooxazole and 5-amino- -1,2,4-oxadiazole or 5-amino-1,2,4-oxathiazole, preparation method thereof and pharmaceutical composition containing the same
Inventor: BERNAT ANDRE
IPC: A61P9/08
Filed: 1990-12-14
Abstract: The derivative of 2-aminothiazole or 2-aminooxazole and 5-amino-1,2,4-oxadiazole with a general formula (I) where A means O or S atom, B means C or N atom, Z1 means C1-4 alken or phenylene and Z2 means C14 alkylen, W means group -NR1R2, where R1 means H or C1-4 alkyl and R2 means H or C1-4 alkyl and R2 means H or C1-4 alkyl, or it means groups -CONQ1Q2 or CSNQ1Q2 or CSNQ1Q2, where Q1 and Q2 mean H or C1-4-alkyl independent of each other, or it means groups -SO2Q3 or -COQ3, where Q3 means H or C1-4 alkyl, group COOQ4, where Q4 means H or C1-4-alkyl, or benzyl, or R1 and R2 together with the hydrogen atom to which they are bond, create a saturated heterocyclic residue as morpholine, pyrrolidine, piperidine, piperazine or 4-alkylpiperazine residue with 1 up to 3 carbon atoms in the alkyl part, or W means amine N-oxid with a formula NR1R2 or C1-4, or C1-4, alkoxy or C1-4 thioalkoxy group, group CONQ1Q2 or CSN-QQ2, pyridyl, imidazolyl or COOQ5, where Q5 means C1-5 alkyl, R3 is absent, if B means N, in the case B means C, R3 means H or C1-8 alkyl or halogen, Ar1 means phenyl or substituted halogen atom, while this atom can be substituted by alkyl, alkoxy group or thioalkoxy group always with C1-4 carbon atoms, by hydroxy group, carboxy group, group COOQ6 or COSQ6, where Q6 means C1-4 alkyl, group carboxamido, cyano, amino, acetamido, nitro or trifluoromethyl group or it means Ar1, thienyl residue, furyl, indolyl, naphtyl, benzyl or cyclohexyl residue or Ar1 and R3, they create together group closed to the formula (a), where Xp the same or the different mean H atom or C1-3 alkyl or halogen atom, q means 2 up to 4 np means 1 up to 3, while carbon atom closed to phenyl residue is bound in a position 4 of the heterocyclic residue, Ar2 means pyrimidinyl, quinolyl, isoquinolyl, indolyl, isoindolyl or pyridyl, always substituted with C-13 alkyl or alkoxyl, or halogen atom and their salts, suitable from pharmaceutical point of view, are the antagonists closed to the factor activating blood plates and in a form of pharmaceutical means, they can be applied for healing of various diseases asthma, as for instance, of several inflammation or allergic states closed to cardiovascular or kidney diseases, however they can be used as contraceptives.
Patent CZ-294369-B6 (CZ)
Title: Tangential cutting insert
Inventor: SATRAN AMIR
IPC: B23C5/22
Filed: 1999-06-29
Abstract: The present invention relates to a tangential cutting insert (1, 60, and 70) having a prismatic body with an operative front surface (2) associated with upper and lower main cutting edges (10). Each upper and lower main cutting edge (10) is disposed between two corner cutting edges (14) arranged in one reference plane (P). Each of the main cutting edges (10) extends from its associated corner edges (14) in an inward direction of the cutting insert (1, 60, and 70) away from the reference plane (P). The operative front surface (2) is associated with two side cutting edges (12), from which each is disposed between two adjacent corner edges (14). All cutting edges (10, 12, 14) have rake surfaces (20, 22, 24) formed at the operative front surface (2) and extending from their associated main, side and corner cutting edges (10, 12, 14) in an inward direction of the cutting insert. The cutting insert has an imaginary reference plane (P) passing through extremities of the cutting corner edges (14) thereof. Each of the main cutting edges (10) extends from its associated corner edges (14) in an inward direction of the cutting insert (1, 60, and 70) along the whole periphery of the operative front surface (2).
Patent CZ-291948-B6 (CZ)
Title: Heat treatment process of ammonia alum to aluminium sulfate and ammonium sulfate
Inventor: NOVAK LUBOS ING CSC
IPC: C01F7/765
Filed: 2001-01-23
Abstract: The invented heat treatment process of ammonia alum to aluminium sulfate and ammonium sulfate by two-stage dehydration and thermal decomposition is carried out in such a manner that in the first stage ammonia alum is brought into contact with combustion products at a temperature ranging from 500 to  900 degC and subsequently it is heated in a fluidized bed for a period of 20 to 60 minutes to a temperature in the range of 140 to 350 degC. Grain size of the obtained intermediate is then adjusted to 0.15 to 0.5 mm and in the second stage said intermediate is dehydrated by contacting thereof with combustion products at a temperature ranging from 300 to 800 degC, whereupon it is subjected to thermal decomposition at a temperature ranging from 550 to 700 degC for a period of 15 to 75 minutes to give crystalline aluminium sulfate. A solution of ammonium sulfate or crystalline ammonium sulfate is obtained by absorption from gaseous components and optional subsequent crystallization.
Patent CZ-301152-B6 (CZ)
Title: Method, device and test specimen for dynamic testing of building material thermal properties
Inventor: ZARUBA JAN
IPC: G01N25/00
Filed: 2007-12-28
Abstract: The invented method of dynamic testing of building material thermal properties comprises comparing records of temperature course during balancing temperature of liquids in vessels (7) and (8) separated from each another within a thermally insulated box (5) by a partition formed by a test specimen to be tested with temperature course determined during identical experiment carried out with a reference of standard material of known thermal properties, preferably close to the material under test. A temperature course is sensed in at least five points, i.e. in the center of the first vessel (7) of a warm liquid, in the center of the second vessel (8) of a cold liquid and in transverse axis of the test specimen (1) being tested, in at least three levels, preferably 1 cm from surfaces of the test specimen (1) and in the center thereof. Estimate of heat conductance is derived from the rate of equalization of temperatures in the vessels (7) and (8) determined at equaled temperature gradient in the test specimen (1) under test. Specific heat capacity is derived from changes in average temperature of liquid charges of the vessels (7) and (8) determined after equalization of their temperatures or more quickly by estimate based on determination of the movement rate of temperature wave induced in the partition of the material being tested by an initial step change in temperature of same of the water charges of vessels (7) and (8) or from ration of temperature differences measured in the test specimen (1) by thermometers (16) and (17). Device for making the above-described method comprises a heat-insulated regular tetrahedral box (5) with a first insulation layer (6) and a removable cover (12) provided from inside with a second insulation layer (13). In the middle of the box (5) and the cover (12) there is performed a peripheral groove (9) leading through the center of the cover (12), the center of a first sidewall, the bottom and opposite third sidewall of the box (5). Said peripheral groove (9) serves for insertion therein a test specimen (1) provided with at least one internal thermometer (17) and two external thermometers (16) with a first cable outlet (4). A vertical groove (11) performed in the bottom of said peripheral groove (9) side section serves for leading said cable out of the box (5). The test specimen (1) forms a vertical partition separating the interior of the box (5) into two identical mirror-symmetrical spaces for insertion of a first and a second vessels (7 and 8) containing liquid of a selected temperature. The test specimen (1) consists of at least two identical standardized test bodies (24) for strength mechanical tests of the given material, arranged one above another in the form of a plate. A thermometric splint (3) of foamy material with closed structure of low-order thermal conductance if compared with thermal conductance of the test bodies (24) is inserted in one joint extending between two adjacent test bodies (24).
Patent CZ-306739-B6 (CZ)
Title: A multilayer plastic pipe
Inventor: NOVOTNÝ TOMÁŠ
IPC: B29C48/21
Filed: 2008-03-18
Abstract: The multilayer plastic pipe comprises at least three axially concentric and mutually rigidly bonded layers of polyethylene based materials having a different molecular and supramolecular structure. The inner layer has a thickness equalling to 1/10 to 1/4 of the total thickness of the pipe wall and is made of a homopolymer of ethylene with a unimodal molecular weight distribution of a density of 0.94-0.95 g/cm3, and the tensile modulus at 23°C of at least 0.8 GPa. The middle layer has a thickness equalling to 1/2 to 7/10 of the total thickness of the pipe wall and is of a homopolymer of ethylene with a bimodal molecular weight distribution of a density of at least 0.95 g/cm3 with a tensile modulus at 23°C of at least 0.9 GPa and a yield strength at 23°C of at least 22 MPa. The outer layer has a thickness equalling to 1/5 to 3/10 of the total thickness of the pipe wall and is made of a copolymer of ethylene with .alpha.-olefin selected from the group consisting of propene, 1-butene, 1-hexene and 1-octene with a bimodal molecular weight distribution of a density of 0.94-0.96 g/cm 3. and a tensile modulus at 23°C of at least 0.8 GPa.
Patent CZ-303399-B6 (CZ)
Title: GLP-1 peptide analogue and pharmaceutical composition containing thereof
Inventor: DONG ZHENG XIN
IPC: A61P25/28
Filed: 1999-12-07
Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1 (GLP-1) of the general formula I in which the meaning of substituents is indicated in the Claims, the pharmaceutically acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.
Patent CZ-305967-B6 (CZ)
Title: Vocal chord prosthesis and method of tuning such vocal chord prosthesis
Inventor: Vampola Tomáš
IPC: A61M16/04
Filed: 2015-03-23
Abstract: The present invention relates to an artificial vocal chord (1), which is a two-part vocal chord and the parts thereof are slidably mounted in cross direction in opposite walls of a guide frame (5) while in longitudinal direction they are attached to one side of the guide frame (5) attachment wall (9) and to an adjustment frame (6) attachment wall (9) on the opposite side, whereby the inner space (4) of the artificial vocal chord (1) is connected to a pressure liquid source. The invention further relates to a method of tuning such vocal chord prosthesis, which tuning method is characterized in that there is determined a base frequency of a human vocal chord, and based thereon there is created a base prestress of the artificial vocal cord by adjusting the distance of the guide frames (5) and the adjustment frames (6) encompassing the artificial vocal chord. Subsequently, there are changes vibration characteristics of the artificial vocal chord by the change in a liquid pressure in the artificial vocal chord. The changes are monitored and compared with required vibration characteristics for a human vocal chord until details of the compared vibration characteristics of both the artificial and human vocal chords are obtained.
Patent SK-286308-B6 (SK)
Title: Aromatic derivatives and iron complexes thereof for use as normalising agents of iron level
Inventor: DI NAPOLI GUIDO
IPC: A61K31/00
Filed: 1999-10-29
Abstract: The aromatic derivatives of the formula (I), wherein R1 is (a), wherein R3 and R4 are selected from between H and OH, provided that R3 and R4 are not simultaneously H, and R2 is H; or R1 and R2 taken together are (b), wherein R5 is selected from between CH3 and (CH2)5OH; the iron complexes thereof and their use for the preparation of pharmaceutical compositions for the normalisation of iron level.
Patent SK-287058-B6 (SK)
Title: Sulphonamide derivatives, method of their preparation, pharmaceutical formulations containing thereof and their use
Inventor: ARKINSTALL STEPHEN
IPC: A61P25/28
Filed: 2000-09-28
Abstract: There are described sulphonamide derivatives of formula I, method of their preparation, pharmaceutical formulations containing such sulphonamide derivatives and their use as to pharmaceutical formulations of the JNK pathway. They are in particular efficient and selective inhibitors of JNK 2 or 3.
Patent CZ-297780-B6 (CZ)
Title: Aqueous pharmaceutical composition
Inventor: NAGANO ATSUHIRO
IPC: A61K31/58
Filed: 2000-10-20
Abstract: The present invention provides an aqueous pharmaceutical composition containing ciclesonide and hydroxypropylmethylcellulose, wherein the ciclesonide is dispersed in an aqueous medium in the form of solid particles. The composition is able to avoid variations in the concentrations of ciclesonide during preparation as well as avoid decreases in the recovery rate (yield) of ciclesonide.
Patent CZ-302839-B6 (CZ)
Title: Grate furnace
Inventor: MARTIN JOHANNES
IPC: F23H7/08
Filed: 2002-07-23
Abstract: In the present invention, there is disclosed a grate furnace with a grate (4) consisting of grate steps (15, 16, 17) composed of grate elements lying next to one another, of which grate steps in each case every second grate step (15, 17) in the longitudinal direction of the grate (4) can be driven for carrying out stoking movements and the grate steps (17) in each case lying therebetween can be fixed, has drive devices (18) under the grate (4) , which are in each case arranged in housing chambers (25) and are in this way protected against impairment caused by material falling through the grate (4).
Patent CU-23706-B7 (CU)
Title: Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparación y las composiciones farmacéuticas que las contienen
Inventor: CHIMENTI STEFANO
IPC: A61K31/55
Filed: 2008-09-11
Abstract: Compuestos de fórmula (I): ESPACIO PARA FÓRMULA en la que: -R1 representa un átomo de hidrógeno o un grupo elegido entre cicloalquilo, bencilo y alquilo opcionalmente sustituido, -R2, R3, R4 y R5 representan cada uno un átomo de hidrógeno o un grupo hidroxi, metilo, -OSO2R10,- OCOR10, alcoxi opcionalmente sustituido, o bien R2 y R3, o R3 y R4, o R4 y R5 forman juntos un grupo -O-(CH2)q-O-, -O-CH=CH-O- o -O-CH=CH-, -R6, R7, R8 y R9 representan cada uno un átomo de hodrógeno o un grupo alcoxi, o bien R6 y R7, o R7 y R8, o R8 y R9 forman juntos un grupo -O-(CH2)q-O-, -R10 representa un grupo elegidoentre alcoxi C1-C6 lineal o ramificado, NR11R'11 y alquilo opcionalmente sustituido, -R11 y R'11 representan cada uno un átomo de hidrógeno o un grupo alquilo, o bien R11 y R'11 forman juntos, con el átomo de nitrógeno que les soporta, un heterociclo nitrogenado mono-o bicíclico opcionalmente sustituido, - X representa O, NH o CH2 - m yp representan cada uno 0 ó 1, - n y q representan cada uno 1 ó 2, en forma racémica o de isómeros ópticos, así como sus sales de adición con un ácido farmacéuticamente aceptable.
Patent EP-1297784-B8 (EP)
Inventor: VETTER ROLF
IPC: A61B5/024
Filed: 2001-09-28
Granted: 2011-01-12
Abstract: There is described a device and a method for detecting the pulse rate. The measuring principle consists of emitting radiant energy at the surface of or through human body tissue (5) by means of a light-emitting source (10), measuring the intensity of the radiant energy after propagation through the human body tissue by means of at least first and second light detectors (21, 22, 23, 24) located at a determined distance from the light-emitting source and providing first and second input signals (y1(t), y2(t)) representative of this propagation. Simultaneously, a motion detecting device (40), such as a three dimensional accelerometers, provides a motion reference signal (ax(t), ay(t), az(t)) representative of motion of the detecting device on and with respect to the human body tissue (5). The input signals are then processed in order to remove motion-related contributions due to motion of the detecting device (1) on and with respect to the human body tissue (5) and to produce first and second enhanced signals. This processing basically comprises the elaboration of a model of the motion-related contributions based on the motion reference signal and the subtraction of this model from each of the input signals. Pulse rate is then extracted from the enhanced signals using for instance a maximum likelihood histogram clustering technique. <IMAGE>
Patent EP-1543311-B8 (EP)
Inventor: KRAUS STEFFEN
IPC: G01N1/06
Filed: 2003-09-04
Granted: 2011-10-05
Abstract: The invention relates to a rotary microtome, comprising a micrometric mechanism (1), a specimen holding device (2) assigned to said micrometric mechanism (1), a drive (3) for the micrometric mechanism (1) serving to vertically displace the specimen holding device (2), a stand for holding the micrometric mechanism (1) and, optionally, the drive (3), a housing (5), and comprising a knife holding device (6), which supports a knife (7) and which is situated opposite the specimen holding device (2) while being located outside of the housing (5). The rotary microtome is characterized in that the stand has a surrounding wall (8) whereby forming a monolithic housing (5).
Patent EP-1722887-B8 (EP)
Inventor: ZSCHAU WERNER
IPC: C01B33/42
Filed: 2005-03-08
Granted: 2018-08-22
Abstract: A process is described for reducing the dioxin content of a composition comprising at least one dioxin-containing raw clay or a dioxin-containing bleaching earth, characterized in that the composition is heated to a temperature in the range of about 125 to 650° C.
Patent BR-PI0314501-B8 (BR)
Inventor: MANUEL VANGELISTI
IPC: C07D213/61
Filed: 2003-11-18
Abstract: Process for the preparation of 2-aminomethylpyridine derivative of general formula (I) : <CHEM> in which :  n represents 0, 1, 2 or 3, X is halogen atom, Y may be the same or different and may a halogen atom, a halogenoalkyl, a alkoxycarbonyl or a alkylsulphonyl.
Patent BR-PI0614134-B8 (BR)
Title: catalisador de ouro suportado
Inventor: ALIREZA HAJI BEGLI
IPC: B01J35/10
Filed: 2006-08-01
Abstract: catalisador de ouro suportado. a presente invenção refere-se a métodos para a produção de catalisadores de ouro suportados a partir de um suporte de óxido metálico poroso e um precursor de ácido cloroáurico, em que o suporte é colocado em contato com a solução aquosa do precursor de ácido cloroáurico. a presente invenção também se refere a um catalisador de ouro suportado em óxido metálico e seu uso na oxidação de álcoois, aldeidos, compostos polihidróxi e carboidratos.
Patent BR-PI0708909-B8 (BR)
Title: uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna
Inventor: LEONARD BELL
IPC: A61K38/00
Filed: 2007-03-15
Abstract: composto ultilizado na preparação de um medicamento para tratamento de pacientes com hemoglobinúria paroxística noturna através de um inibidor de complemento. eculizumab, um anticorpo monoclonal humanizado contra c5 que inibe a ativação do complemento terminal, mostrou atividade em uma triagem de marcação aberta de 12 semanas preliminar em um pequeno grupo de pacientes com hemoglobinúria paroxísta noturna (hpn). o presente estudo examinou se a terapia crônica com eculizumab pode reduzir hemólise intravascular, estabilizar níveis de hemoglobina, reduzir requerimentos de transfusão, e melhorar a qualidade de vida em uma triagem global de fase iii do tipo duplo-cego, aleatória, placebo-controlado, multi-cêntrica. tem sido encontrado que eculizumab estabilizou os níveis de hemoglobina, diminui a necessidade de transfusões, e melhorou a qualidade de vida em pacientes hpn através de uma via de hemólise intravascular reduzida. tratamento crônico com eculizumab aparenta ser uma terapia segura e eficaz para pnh.
Patent BR-PI0715151-B8 (BR)
Title: método para gerar uma espuma termoplástica a partir de uma dispersão aquosa
Inventor: LUTHER STOCKTON
IPC: A61L15/42
Filed: 2007-09-21
Abstract: método para gerar uma espuma termoplástica a partir de uma dispersão aquosa, espuma e artigo absorvente. método para gerar uma espuma termoplástica a partir de uma dispersão aquosa, a dispersão aquosa compreendendo uma resina termoplástica, água, e um agente estabilizador de dispersão, o método incluindo: adicionar pelo menos um tensoativo estabilizador de espuma úmida na dispersão aquosa para formar uma mistura; adicionar fibras na mistura; e espumar a mistura para criar uma espuma úmida; remover pelo menos uma porção da água na espuma úmida para criar uma espuma, sendo que a espuma gerada tem uma morfologia fibriliada não-celular e uma densidade média de cerca de 0,02 g/cm ^3^ a cerca de 0,07 g/cm ^3^; em determinadas incorporações, a espuma ser usada num artigo absorvente.
Patent BR-PI0804091-B8 (BR)
Title: compostos de 1,2,4,5-tetrahidro-3h-benzazepina, processo para sua preparação e composições farmacêuticas que os contêm
Inventor: AIMEE DESSINGES
IPC: C07C13/44
Filed: 2008-09-11
Abstract: compostos de 1,2,4,5-tetrahidro-3h-benzazepina, processo para sua preparação e composições farmacêuticas que os contêm. compostos de fórmula (i): na qual: - r1 representa um átomo de hidrogênio ou um grupo selecionado a partir de cicloalquila, benzila e alquila opcionalmente substituída, - r2, r3, r4 e r5 cada um representa um átomo de hidrogênio ou um grupo hidróxi, metila, -oso2r10, -cocr10 ou alcóxi opcionalmente substituído, ou r2 e r3, ou r3 e r4 ou r4 e r5, em conjunto, formam um grupo -o-(ch2)q-o-, -o-ch=ch-o- ou -o-ch=ch-, - r6, r7, r8 e r9 cada um representa um átomo de hidrogênio ou um alcóxi, ou r6 e r7, ou r7 e r8 ou r8 e r9, em conjunto, formam um grupo -o-(ch2)q-o-, - r10 representa um grupo selecionado a partir de c1-c6-alcóxi linear ou ramificado, nr11r'11 e alquila opcionalmente substituída, - r11 e r'11 cada um representa um átomo de hidrogênio ou um grupo alquila, ou r11 e r'11, em conjunto com o átomo de nitrogênio que os porta, formam um heterociclo contendo nitrogênio, monocíclico ou bicíclico, opcionalmente substituído, - x representa o, nh ou ch2, - m e p cada um representa o ou 1, - n e q cada um representa 1 ou 2, em forma racêmica ou na forma de isômeros ópticos e também sais de adição dos mesmos com um ácido farmaceuticamente aceitável. medicamentos.
Patent AU-2008320632-B8 (AU)
Title: Improvements in and relating to scanning confocal microscopy
Inventor: WOODS DAVID
IPC: G02B21/00
Filed: 2008-10-27
Granted: 2013-02-28
Abstract: Known scanning confocal microscope systems use an optical fibre to deliver light to the confocal scanning head. The illumination from the fibre may be uneven and significant light loss may occur in the fibre. According to the invention, an assembly is provided for inputting a light beam from a light source into the confocal scanning head of a scanning confocal microscope system, wherein the assembly comprises a beam width adjuster (6a, 6b), a beam director (8, 10) for controlling the path of the light beam, and a beam focussing means (12) for bringing the beam to a focus at a predetermined point at a light input of said confocal scanning head.