baber/WOPTO huggingface dataset:
Patent SG-11201908540P-A (SG)
Title: Stable antibody formulation
Inventor: HU QINGYAN
IPC: A61K9/00
Filed: 2018-03-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit IIl °nolo mo 110n rum° oimIE (10) International Publication Number WO 2018/187057 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 47/26 (2006.01) A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 47/18 (2017.01) (21) International Application Number: PCT/US2018/024032 (22) International Filing Date: 23 March 2018 (23.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,270 06 April 2017 (06.04.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). (72) Inventors: HU, Qingyan; 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). LIU, Dingjiang; 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (74) Agent: EL HIOUM, Dianna G.; Fox Rothschild LLP, 997 Lenox Drive, Lawrenceville, NJ 08648-2311 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 1-1 N O N 00 1-1 00 O N O (54) Title: STABLE ANTIBODY FORMULATION (57) : The present invention provides stable pharmaceutical formulations comprising a human antibody that specifically binds to human programmed death -1 protein (PD-1). In certain embodiments, the formulations contain, in addition to an anti-PD-1 antibody, a buffer, an amino acid, a non-ionic surfactant, and a sugar. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability upon stress and storage.
Patent AT-399040-B (AT)
Title: Tile
IPC: F24B1/06
Filed: 1993-01-20
Granted: 1995-03-27
Abstract: A tile consists of a tile sheet 1, the front side 2 of which is provided with glazing, and of a tile body 3. In the rear side 5 of the tile body are provided channels 6 intersecting one another, the intersection points of these channels 6 having rounded corners. Pipes 10 are laid in a serpentine manner in the channels 6 and fixed by spring clips 12, the ends of which can be inserted into orifices 9 in the tile body 3. The side faces 11 of the body 3 terminate flush with those of the sheet 1. <IMAGE>
Patent HU-185026-B (HU)
Inventor: BESAN JANOS
IPC: C07D249/08
Filed: 1981-01-09
Abstract: A találmány új eljárás az 1,2,4-triazol előállítására hidrazin, vagy hidrazin és hangyasav, valamint formamid és/vagy ammónia reakciójával. A hidrazint, vagy a hidrazint és a hangyasavat, vagy azok vizes oldatait 1 ;0—3 mólarányban formamiddal és/vagy ammóniával 140— 220 °C-on reagáltatva jó hozammal és tisztasággal nyerik az 1,2,4-tirazolt. A feleslegben használt, vagy keletkező .formamid és ammónia a folyamatba visszavezethető. I *· H-CC - NHo | N ---NH |   +C0+2HO N IL -1-
Patent YU-48382-B (YU)
Title: Postupak za izradu katalizatora za polimerizaciju olefina
Inventor: BENHAM
Filed: 1993-02-05
Abstract: POSTUPAK ZA IZRADU KATALIZATORA ZA POLIMERIZACIJU OLEFINA naznačen time, što reaguje izvor metala i jedinjenje koje sadrži pirol i alkil metala, u zajedničkom rastvaraču, bez prethodnog reakcionog stupnja izmedju izvora metala i jedinjenja koje sadrži pirol, u prisustvu elektrodonornog rastvarača. - Prijava sadrži još 1 nezavisan i 35 zavisnih zahteva.
Patent AT-403469-B (AT)
Title: Magazine for filling a goods-discharging apparatus
Inventor: NEUKAM HELMUT ING
IPC: B65G1/137
Filed: 1996-03-04
Granted: 1998-02-25
Abstract: Magazine for filling a goods-discharging apparatus, having essentially vertically running filling shafts, which can be filled essentially via filling openings extending over the entire height, and having ejectors arranged at the bottom ends of said filling shafts. In order to allow straightforward filling of a goods- discharging apparatus, it is provided that the essentially rectangular magazine is bounded by side walls 3, 4 on just three sides and has a base 1 which is inclined in relation to the standing plane and, in the direction of one side edge, runs parallel to the standing plane, it being the case that the side wall 4, which runs along the lower-level edge of the base 1, said edge running parallel to the standing plane, has an essentially rectangular slit 5 which extends essentially over the entire length of said side wall 4 and into which an ejector 9 can be pushed. <IMAGE>
Patent AT-399956-B (AT)
Title: Portable data carrier
IPC: G06K19/02
Filed: 1993-04-05
Granted: 1995-08-25
Abstract: Portable data carrier 1 for applications such as as cards for bank transactions, such as cheque, ATM and credit cards, access, club, telephone and identity cards, or the like, having one or more electronic storage media 2, such as magnetic strips, chips, microchips, ICs, magneto optical storage media or the like, semiconductor circuit elements, of any desired, preferably layer-like construction, characterized in that it contains at least one layer of wood 3 or is constructed from wood. <IMAGE>
Patent HU-212880-B (HU)
Title: Insecticidal product comprising pyrethroid
Inventor: BENCSITS FRANZ
IPC: A01M1/20
Filed: 1991-09-12
Abstract: PCT No. PCT/EP91/01736 Sec. 371 Date May 4, 1993 Sec. 102(e) Date May 4, 1993 PCT Filed Sep. 12, 1991 PCT Pub. No. WO92/03927 PCT Pub. Date Mar. 19, 1992The invention relates to an insecticidal product which comprises a vehicle impregnated with an insecticidal composition. The insecticidal composition contains at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives, ascorbyl palmitate and citric acid esters and is preferably applied onto a polyethylene sheet as an emulsion. The product is used as a "carpet" for controlling flying and crawling insects such as flies and cockroaches.
Patent YU-48561-B (YU)
Inventor: DR MASNIKOSA VUKASIN PROF
Filed: 1995-07-10
Abstract: Sistem za regulaciju temperature i zaštitu bojlera smešten u jedno kućište, naznačen time, što se sastoji od dva kapilarna pretvarača temperature u mehanički pomak (14), strujnih provodnika od kojih se svaki sastoji od tri dela (23,24,25) i (26,27,28), dvokontaktnih konzola (7) koje su pričvršćene na kraju pljosnate elastične opruge (6), pretvaranjem mehaničkog pomaka pretvarača temperature (14) u dovoljno velik pomak pomoću posebne pljosnate elastične opruge (16) spojene zglobom sa osovinom (12), kazaljke (11) i osovine (10), indikatora (3) uključenja bojlera na napojnu energetsku mrežu i posebno izvedenog kontakta (35). -Prijava sadrži još 6 zavisnih zahteva.
Patent YU-47997-B (YU)
Title: Induktivno kapacitivna sonda
Inventor: KRSTIC J
Filed: 1990-03-23
Abstract: INDUKTIVNO KAPACITIVNA SONDA koja ima cener diodu (ZY) i elektrolitski kondenzator (C1) za stabilizaciju jednosmernog napona, naznačena time, što je u spojnoj tački kondenzatora (C2) i promenljivog otpornika (R6) vezana sonda (S), gde je vezan i gate (G1) MOS-FETs tranzistora (TR) čiji je sport (s) vezan na tačku (B), pri čemu je u kolu gate (G2) vezan otpornik (R1), dok je drein (D) MOS-FETs tranzistora (TR) vezan na bazu tranzistora (TR1) kao i otpornik (R2), koji je drugim krajem vezan na tačku (A) na koju je vezan i kolektor tranzistora (TR1), i što je emitor tranzistora (TR1) vezan na tačku (B) prko paralelne veze otpornika (R3) i kondenzatora (C3) i na bazu tranzistora (TR2) preko otpornika (R4) i što su u kolu kolektora tranzistora (TR2) paralelno vezani otpornik (R5) i led dioda (LED) čiji je drugi zajednički kraj vezan u tačku (A), pri čemu je između tačaka (A) i (B) vezan napon napajanja.
Patent AT-389934-B (AT)
Title: Atmospheric gas burner
IPC: F23D14/04
Filed: 1987-06-12
Granted: 1990-02-26
Abstract: Atmospheric gas burner with a plurality of approximately vertically arranged mixing tubes 2 which serve for supplying a gas/air mixture and which open jointly into a burner chamber 1 surrounded by a wall having fuel outlet orifices on its top side, the mixing tubes 2 being arranged below the burner chamber, the initial region of the mixing tubes which in each case faces a gas nozzle 4 being arranged virtually horizontally, and the mixing tubes having a deflection 13. In order to achieve the object of ensuring that the inflows of air into the mixing tubes, as far as possible, do not impede one another, the inlets 3 of the mixing tubes 2 are arranged in different vertical planes, for example staggered or offset relative to one another. <IMAGE>
Patent AT-403709-B (AT)
Title: Paving stone in the form of an angled-off cuboid
IPC: E01C5/06
Filed: 1993-10-05
Granted: 1998-05-25
Abstract: Paving stone in the form of an angled-off cuboid, the bottom and top faces of which comprise a square and a rhombus attached thereto, the wedge angle γ at the boundary between the square and the rhombus being less than 180 degree by a predetermined amount and the aperture angle α of the rhombus being less than 90 degree by the same predetermined amount. Continuous clearances 4 may be formed at the edges between the bottom and top faces. <IMAGE>
Patent AT-396483-B (AT)
Title: DC electric arc steel-making furnace - has peripheral electrodes and bottom anode to obtain high energy input without high capital and operating costs
Inventor: BERGER HARALD DIPL ING DR
IPC: C21C5/52
Filed: 1991-11-18
Granted: 1993-09-27
Abstract: Steel is produced in a DC arc furnace with peripheral C electrodes inclined at an angle and directed towards a bottom anode. The arc is formed between the electrodes and the anode. A gas burner projects into the furnace at a level above that of the electrodes. After scrap is charged, natural gas is supplied through the electrode cavities and is broken down by the arc.
Patent AT-387985-B (AT)
Title: Process for producing rolling steel
Inventor: SCHUMMER ARTHUR
IPC: C21D9/52
Filed: 1981-10-14
Granted: 1989-04-10
Abstract: Process for producing rolling steel which includes at most 0.16 per cent of carbon, 2.0 per cent of manganese and at least 0.03 per cent of aluminium and if appropriate up to 0.05 per cent of silicon, 0.55 per cent of niobium, 0.1 per cent of vanadium and 10 per cent of nickel, remainder iron, and is melted, cast, rolled and/or thermomechanically stretched and finally subjected to a heat treatment, in which it is rapidly heated to an austenitizing temperature with an increase in the number of nuclei, is briefly held at this temperature, while avoiding grain coarsening, and is then at least superficially quenched, Martensite forming at the surface and ferrite and pearlite forming in the core, whereupon air cooling takes place, with reheating of the surface as a result of dissipation of heat from the core, tempered Martensite being formed at the surface.
Patent CH-643101-B (CH)
Inventor: AURELE MAIRE
IPC: G04G5/00
Filed: 1981-02-23
Abstract: The correction device of the invention makes it possible to activate, in the same axial position of the crown, two different modes of correction of the data displayed by the watch, it being possible to make those corrections in both directions, depending on the direction of rotation of the crown. The second correction mode is activated only after a reversal of direction of the correction made according to the first mode. This device contains, notably, memory means 11, 12, associated with each direction of rotation of the crown, and selection means 21, 31, 22, 32, for choosing the mode and the direction of correction activated in accordance with the direction of rotation of the crown, on the one hand, and a possible reversal of that direction, on the other.
Patent DK-153737-B (DK)
Inventor: GUILLEMIN GENEVIEVE
IPC: A61F2/00
Filed: 1980-07-11
Abstract: A biodegradable bone prosthesis or implant is made of a coherent material comprising calcium carbonate in crystalline form. The prosthesis or implant is in the form of a filler or replacement part for bone substance. It can also be in the form of a pin or screw.
Patent DK-162724-B (DK)
Inventor: FOX RODNEY THOMAS
IPC: C10L7/02
Filed: 1981-08-31
Abstract: A combustible composition comprising a fuel in the form of a wax, gel, or paste having dispersed therein an inorganic, particulate, noncombustible solid serving to decrease the rate at which the fuel burns on combustion of the composition, and optionally a combustible filler material, the composition being such that it does not flow substantially during combustion.
Patent DK-151216-B (DK)
Inventor: BERGLUND HANS ARNE LENNART
IPC: C01B25/238
Filed: 1980-12-22
Abstract: A method of removing heavy metals, particularly cadmium, from wet-process phosphoric acid produced by digesting raw phosphoric material with sulphuric acid, by precipitating out the heavy metals in sulphide form. The residual sulphuric acid is removed first by neutralization with alkali or as a not-readily dissolved sulphate precipitate. Alkali is added to obtain an Me/P ratio within the range of about 0.05-0.3, where Me is the number of catio equivalents in the alkali and P is the number of phosphorous atoms in the phosphoric acid, whereafter the heavy metals are precipitated out by adding a sulphide compound which is soluble in the phosphoric acid, and the sulphide precipitate removed.
Patent FI-70839-B (FI)
Inventor: THOMPSON JAMES EDWARD
IPC: B60N2/54
Filed: 1981-12-21
Granted: 1986-07-18
Abstract: A multi-directional vibration attenuator seat is capable of limited, restrained movement in any direction within a generally horizontal plane in response to vibration and other motions of the seat and the vehicle in which the seat is mounted. The limited movement is made possible by a seat arrangement in which an intermediate assembly is disposed on top of and slidable relative to a base assembly along a first axis with a seat supporting upper assembly being disposed on and slidable relative to the intermediate assembly along a second axis extending in a direction generally perpendicular to the direction of the first axis. The seat is normally maintained in and is restrained from movement out of a nominal position relative to the base assembly by a plurality of springs. A pair of shock absorbers disposed generally perpendicular to each other damp movement of the seat along the first and second axes respectively. An adjuster latch and lever arrangement is used to position the base assembly at a selected location along a pair of slidable adjusters on which the base assembly is mounted. Attenuating movement of the seat can be locked out by a manually controlled lever which drops a pin through an aperture in the base assembly from the upper assembly to lock the various assemblies together. The seat is preferably mounted for rotation about the upper assembly, which rotation can be locked out by a swivel lock lever and toothed plate arrangement.
Patent FI-92215-B (FI)
Inventor: HOSHI KAZUO
IPC: C08F255/00
Filed: 1987-07-16
Granted: 1994-06-30
Abstract: A flame-retardant olefinic resin composition comprising   (A) l00 parts by weight of a mixed resin consisting of an olefinic resin and a silane-grafted polymer obtained by grafting a silane to said olefinic resin,   (B) 50 to 300 parts by weight of a hydrated metal compound, and (C) 0.l to 30 parts by weight of a dicarboxylic acid or dicarboxylic acid anhydride derivative. c
Patent FI-83925-B (FI)
Inventor: STEINMETZER KARL
IPC: A47C7/00
Filed: 1987-09-08
Granted: 1991-06-14
Abstract: PCT No. PCT/SE86/00110 Sec. 371 Date Nov. 7, 1986 Sec. 102(e) Date Nov. 7, 1986 PCT Filed Mar. 13, 1986 PCT Pub. No. WO86/05373 PCT Pub. Date Sep. 25, 1986.A composite leg-support with high loadability having a tubular vertical shank (4) and legs (1) which are releasably affixed to the shank and extending essentially horizontally and radially therefrom. The ends of the legs (1) pointing toward the center of the shank (4) have extensions (2, 3, 13, 18) which protrude into the interior of the shank (4), through openings (5) distributed along the periphery of the shank (4), and they engage in a force-locking manner with profiled discs (6, 10, 15) contained in the shank (4). The discs (6, 10, 15) are pressed towards one another by means of screw (11) extending along the longitudinal axis of shanks (4) and it is accessible from the lower end portion thereof.
Patent FI-86361-B (FI)
Inventor: RIJKAART CORNELIS
IPC: A21C3/02
Filed: 1989-01-25
Granted: 1992-05-15
Abstract: System for forming a laminate consisting of dough and fat, comprising in a single reducing station (1 min , 1 sec ) first (12, 16; 29, 31) and second (13, 17; 29, 33) reducing means which are each suitable for receiving a first (8) and second (10) ingoing layer consisting of dough and fat and for delivering a first (9) and second (11) outgoing layer, less thick than the respective ingoing layers, a laminating station (2 min ) which is suitable for receiving the first outgoing layer (9), and for partially placing on each other of parts of the first outgoing layer (9) for forming and delivering the second outgoing layer (10), with a displacement direction opposite to the first outgoing layer (9), and comprising first to fourth conveyor means (4 to 7), having essentially parallel running conveyance directions for conveying the layers (8 to 11) thereon.
Patent FI-100719-B (FI)
Inventor: COY DAVID H
IPC: C07K1/113
Filed: 1989-05-23
Granted: 1998-02-13
Abstract: A linear peptide which is an analog of a naturally occurring, biologically active bombesin having an active site and a binding site responsible for binding of bombesin to a receptor on a target cell, cleavage of a peptide bond in the active site of the naturally occurring peptide being unnecessary for in vivo biological activity, the analog having a non-peptide bond instead of a peptide bond between an amino acid of the active site and an adjacent amino acid, and having the same binding site as the naturally occurring peptide, so that the analog, is capable of acting as a competitive inhibitor of naturally occurring bombesin by binding to the receptor and, by virtue of the non-peptide bond, failing to exhibit the in vivo activity of naturally occurring bombesin.
Patent FI-102333-B (FI)
Inventor: LIPTAK GABOR
IPC: H02K3/34
Filed: 1989-11-09
Granted: 1998-11-13
Abstract: In an insulating system for high-voltage machines, a three-layer insulating tape is proposed as turn-to-turn insulation which comprises a center mica layer (1) which is covered on both sides by plastic foils (2,3) having different thickness. Thermoplastic adhesive layers (4,5) on the outer surfaces of the foils (2,3) produce an intimate bonding of the turn-to-turn insulation to the conductor elements and to the main insulation. An insulation of such construction is distinguished by a high electrical life at increased temperature and a high surge withstand capability.
Patent FI-87347-B (FI)
Title: Process and device for breaking an optical fibre
Inventor: TEURLINGS LUCAS GERARDUS CHRIS
IPC: C03B37/16
Filed: 1990-05-17
Granted: 1992-09-15
Abstract: A device for crosscutting an optical fibre comprises mounting units 2 and 4 for the fibre, each of which units comprises a hard component 6 and 6' onto which a strip 8 and 8' made of a flexible material, for example synthetic felt, has been glued, with it being possible for the components 6 and 6' to be moved between an open position, in which they accept the optical fibre OF between the flexible strips 8 and 8', and a closed position, in which the fibre OF is pressed between the strips 8 and 8'. A fibre holder 9 has been arranged to apply a pulling force P1 to the fibre OF such that it slides between the flexible strips 8 and 8' in the closed position of the components 6 and 6'. Before the fibre is inserted between strips 8 and 8', a V-shaped notch N, at which the fibre is crosscut, has been produced in the fibre. These strips 8 and 8' have been designed such that the fibre OF is firstly, when it slides between the strips 8 and 8', bent in the region around the notch N, after which the direction of bending of the fibre OF is changed so that the fibre OF breaks at the notch N when the fibre holder 9 applies a pulling force P1 to the fibre OF. The fibre holder 9 then releases the one severed end face of the fibre OF from the other 8 and 8'. <IMAGE>
Patent FI-107214-B (FI)
Inventor: BALLANCE JOHN WILLIAM
IPC: H04B10/035
Filed: 1990-05-25
Granted: 2001-06-15
Abstract: A central station (4) for a digital communications network comprising a plurality of outstations (8) and a branch network of waveguides comprising a single waveguide (6) from the central station, one or more passive splitters (1) and two or more secondary waveguides (14) for onward transmission to the outstations: the central station comprising; means for transmitting data to outstations in the form of a stream of frames, each comprising a synchronisation signal in the form of a predetermined pattern of bits; scrambling means for scrambling the frames in accordance with a predetermined binary sequence; and means for detecting in data received from the outstations the presence of the scrambled synchronisation signal thereby obtaining information concerning reflections in the branch network.
Patent FI-88598-B (FI)
Title: Transport cage
Inventor: KALLIO EERO
IPC: B60P1/56
Filed: 1991-10-14
Granted: 1993-02-26
Abstract: The invention relates to a transport cage, which has sides 1,2 arranged on a base structure 5 and delimiting the loading space, members 6 for opening the discharge opening 7, and a caging belt 8 disposed in the loading space and arranged to guide the material during emptying to the discharge opening 7. In order to produce a reliably working construction, the transport cage comprises a turning member 9 arranged to guide the one end of the caging belt 8 from the starting position to a position in which it covers the open top side of the loading space and back to the starting position, a caging roller 11 arranged on slide shoes disposed on two mutually opposing upper edges of the loading space, and members 13 by means of which the slide shoes can be guided along the upper edges of the loading space to the other edge of the loading space such that the caging roller 11 when it is guided with the slide shoes, together with the motion at the end of the caging belt 8 in the direction of the starting position, which motion is produced by the turning member 9, pushes the caging belt 8 into a position which ejects the material present in the loading space through the discharge opening 7. <IMAGE>
Patent FI-112220-B (FI)
Inventor: FREIDINGER ROGER M
IPC: C07D405/12
Filed: 1992-04-09
Granted: 2003-11-14
Abstract: Benzodiazepine analogs of the formula: <CHEM> are disclosed which are antagonists of gastrin and cholecystokinin (CCK).