Patent SG-11201407964Y-A (SG)
Title: Novel compounds and compositions for treatment of breathing control disorders or diseases
Inventor: MANNION JAMES C
IPC: C07D251/54
Filed: 2013-05-29
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/181217 A2 (51) International Patent Classification: A61K31/53 (2006.01) A61K31/505 (2006.01) C07D 251/54 (2006.01) A61K31/519 (2006.01) C07D 239/50 (2006.01) A61P11/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/043052 29 May 2013 (29.05.2013) English (30) Priority Data: 13/482,837 29 May 2012 (29.05.2012) English US (71) Applicant: GALLEON PHARMACEUTICALS, INC. [US/GB]; 213 Witmer Road, Horsham, PA 19044 (US). (72) Inventors: MANNION, James, C.; 2 Clydesdale Court, Plainsboro, NJ 08536 (US). DAX, Scott, L.; 3 Quail Drive, Landenberg, PA 19350 (US). MACINTYRE, Duncan, Euan; 2127 Bayberry Lane, Scotch Plains, NJ 07076 (US). COLDER, Francis, John; 15b Penns Land­ ing South, Philadelphia, PA 19147 (US). MCLEOD, James, Francis; 237 Jacksonville Road 153f, Hatboro, PA 19040 (US). (74) Agents: SILVA, Domingos, J. et al.; Riverside Law, LLP, 300 Four Falls Corporate Center, Suite 710, 300 Consho- hocken State Road, West Conshohocken, PA 19428 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) (54) Title: NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES CJ l> n oo Morphine JQ mg/kg, IV -Q-20% bcci( N- h) cmpd (A) infusion (N~5) I orwd [A} nu Yw infusion pumps off PI P6 Pll PI 6 71 R> Til Tilt T21 726 HI Ti6 T41 T4f> T5:i 756 W1 Time Periods^mm) i-H o CJ (57) Abstract: The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in subject in a need thereof. The present invention also includes method a of treating a respiratory disease or disorder in subject in a need thereof, comprising administering to the subject a therapeutically effective amount of pharmaceutical formulation of a the in­ vention. The present invention further includes method of preventing destabilization a or stabilizing breathing rhythm in subject in a need thereof, comprising administering to the subject a therapeutically effective amount of pharmaceutical formulation of a the in­ vention.