baber/WOPTO huggingface dataset:
Patent NZ-599143-A (NZ)
Title: Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
Inventor: VENKATESH GOPI M
IPC: A61K38/43
Filed: 2010-09-17
Abstract: 599143 Disclosed is a multi-particulate digestive enzyme composition comprising enterically coated digestive enzyme-containing beads, and uncoated digestive enzyme containing beads, wherein: the enterically coated digestive enzyme-containing beads comprise a core and an enteric coating disposed over the core, wherein the core comprises a therapeutically effective amount of lipase, and the enteric coating comprises an enteric polymer; and the uncoated digestive enzyme-containing beads comprise a therapeutically effective amount of protease, and is substantially free of an enteric polymer coating; wherein the digestive enzymes comprise lipase and protease, and the ratio of lipase and protease activities in the enterically coated digestive enzyme-containing beads to the lipase and protease activities in the uncoated digestive enzyme-containing beads ranges from about 5:95 to about 50:50.
Patent NZ-600125-A (NZ)
Title: Methods of treating or preventing acute erythema
Inventor: ANDRES PHILIPPE
IPC: A61K31/135
Filed: 2010-10-19
Abstract: 600125 A method of treating or preventing acute erythema in a human in need thereof by topical administration of an effective amount of an alpha adrenergic receptor agonist or pharmaceutically acceptable salt thereof is claimed. The alpha adrenergic agonist may be: Brimonidine, oxymetazoline, phenylephrine, methoxyamine, tetrahydrozaline, naphazoline, xylometazoline, epinephrine, and norepinephrine. The preferred alpha adrenergic receptor agonist is brimonidine (i.e. (5-Bromo-quinoxalin-6-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine). A method of preventing secondary inflammation caused by acute erythema by topical administration of an effective amount of an alpha adrenergic receptor agonist or a pharmaceutically acceptable salt thereof is also claimed.
Patent NZ-601066-A (NZ)
Title: A multi-bit tool
Inventor: CREWE WILLIAM
IPC: B25G1/08
Filed: 2011-01-12
Abstract: A multi-bit tool is disclosed including a housing (2) and a drive input shaft (3). The housing (2) includes include a first (6) and a second (7) socket, each axially aligned with the drive input shaft. The first socket (6) is smaller than the second socket (7) so that tool bits (4) driven by the first socket (6) pass through the second socket (7). The housing (2) may incorporate multiple storage recesses (5) for holding tools. The larger socket (7) may provide increased torque for driving larger tools or may directly drive fasteners.
Patent NZ-601858-A (NZ)
Title: Methods and compositions for diagnosis and treatment of amyloidosis
Inventor: WATTS RYAN
IPC: A61K39/395
Filed: 2008-10-03
Abstract: NZ 601858 Disclosed is a method for diagnosing an ocular disease, or a predisposition to an ocular disease, associated with amyloid-beta-related pathological abnormalities or changes in the tissues of the visual system in a subject, comprising detecting immunospecific binding to amyloid-beta of a humanised antibody or an antigen-binding fragment thereof, which recognises and binds to amyloid-beta, in a sample, wherein the method includes the steps of: bringing the sample suspected to contain amyloid-beta protein into contact with the humanised antibody or antigen-binding fragment thereof; allowing the humanised antibody or antigen-binding fragment thereof to form an immunological complex; detecting formation of the immunological complex, such that the presence or absence of the immunological complex correlates with presence or absence of amyloid-beta protein; and correlating the presence or absence of the immunological complex with the presence or absence of amyloid-beta protein in the sample; wherein the humanised antibody or antigen-binding fragment thereof comprises: (a) a heavy chain variable region (”HCVR”) comprising, integrated into human- or primate-derived framework regions: a CDR1 comprising the amino acid sequence of SEQ ID NO: 1, a CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and (b) an LCVR comprising the amino acid sequence of SEQ ID NO: 12; or (a) a light chain variable region (”LCVR”) comprising, integrated into human- or primate-derived framework regions, a CDR1 comprising the amino acid sequence of SEQ ID NO: 4; a CDR2 comprising the amino acid sequence of SEQ ID NO: 5, the amino acid sequence RVSNRFS, or the amino acid sequence KVSSRFS; and a CDR3 comprising the amino acid sequence of SEQ ID NO: 6; and (b) an HCVR comprising the amino acid sequence of SEQ ID NO: 15; or (a) an HCVR comprising, integrated into human- or primate-derived framework regions: a CDR1 comprising the amino acid sequence of SEQ ID NO: 1, a CDR2 comprising the amino acid sequence of SEQ ID NO: 2, a CDR3 comprising the amino acid sequence of SEQ ID NO: 3, a serine in Kabat position 94 of the HCVR framework region, and a leucine in Kabat position 47 of the HCVR framework region; and (b) an LCVR comprising, integrated into human- or primate-derived framework regions: a CDR1 comprising the amino acid sequence of SEQ ID NO: 4, a CDR2 comprising the amino acid sequence of SEQ ID NO: 5 or the amino acid sequence of SEQ ID NO: 5 with one amino acid substitution, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 6; wherein the sequences are as defined in the specification and an increase in the amount of said complex compared to a normal control value indicates that said subject is suffering from or is at risk of developing the ocular disease.
Patent NZ-605562-A (NZ)
Title: Deuterated benzylbenzene derivatives and methods of use
Inventor: NAKAMURA KAZUHIRO
IPC: A61K9/20
Filed: 2009-07-15
Abstract: [OBJECT] To provide an intraorally rapidly disintegrating tablet comprising 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid as an active ingredient, which is a formulation that causes virtually no irritating sensation in the oral cavity or pharynx, and retains good dissolution and oral disintegration properties even when it is stored under high temperature/high humidity conditions.  [MEANS OF REALIZING THE OBJECT] An intraorally rapidly disintegrating tablet comprising a particle containing a 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid-containing core particle coated with a layer comprising a methacrylic acid copolymer and further overcoated with a layer containing a water-soluble saccharide.
Patent NZ-610891-A (NZ)
Title: Cd89 activation in therapy
Inventor: VON GUNTEN STEPHAN
IPC: C07K16/28
Filed: 2011-12-14
Abstract: Discloses use of a CD89-activating molecule in the manufacture of a medicament for the treatment of an autoimmune disorder or inflammatory condition by inducing apoptosis in neutrophils, wherein the CD89-activating molecule is a soluble molecule comprising Fc-alpha or a functional equivalent thereof.
Patent NZ-612450-A (NZ)
Title: Method for enhancing engraftment of haematopoetic stem cells
Inventor: ZEBEDIN-BRANDL EVA-MARIA
IPC: C12N5/078
Filed: 2012-01-13
Abstract: Disclosed is a composition comprising at least one prostacyclin analogue together with an unspecific cAMP activating agent and stimulated haematopoietic stem cells. Also disclosed is a method for enhancing engraftment of haematopoietic stem cells (HSCs) by an ex vivo pretreatment of the HSCs which comprises the following steps: a. using a sample containing haematopoietic stem cells; b. admixing to said sample at least one prostacyclin analogue to obtain a mixture; c. incubating said mixture for a period of time sufficient to stimulate G alpha-s-signalling in said cells. Further disclosed is the use of a composition comprising at least one prostacyclin analogue in the production of a composition for the treatment of individuals suffering from bone marrow disease transplanted with haematopoietic stem cells prepared according to the above method.
Patent NZ-616660-A (NZ)
Title: Connective tissue monitoring, compositions for connective tissue treatment and methods for treating connective tissue
Inventor: DAFFY JOHN
IPC: G06T7/40
Filed: 2011-03-25
Abstract: Disclosed is a composition which comprises: an anti-inflammatory (e.g. ibuprofen, copper ibuprofenate, indomethacin, copper indomethacin, naproxen, flurbiprofen and/or celecoxib); two or more metalloprotease inhibitors (preferably including the tetracycline antibiotic doxycycline, and the antioxidant epigallocatechin gallate (EGCG), or catechin); and an inhibitor of cell activity (i.e. a glucocorticoid steroid) when used in treating a tendon injury in an equine or a canine. Also disclosed is a method for treating a tendon injury in a non-human subject in need thereof, the method including providing a composition comprising a pro-inflammatory cytokine inhibitor; an antioxidant or catechin; and an anti-inflammatory wherein the pro-inflammatory cytokine inhibitor, the antioxidant or catechin and the anti-inflammatory are present in an amount effective to treat the tendon injury; to thereby treat the tendon injury in the non-human subject.
Patent NZ-621686-A (NZ)
Title: System automation via an alarm system
Inventor: WARREN JEREMY BRUCE
IPC: G06F17/00
Filed: 2012-08-06
Abstract: Disclosed is a system (200) for controlling a plurality of systems. The system (200) includes an alarm system controller (206). The alarm system controller includes a dedicated control module, a system automation module (206a) and an interface (206b). The dedicated control module manages a plurality of systems at the alarm system controller (206). At least one of the plurality of systems comprises a security system and the dedicated control module controls the security system. The system automation module (206a) receives weather forecast data from a weather data source (216) and controls at least one system of the plurality of systems based on the weather forecast data. The interface (206b) is configured to transmit one or more commands for controlling the at least one system (202a).
Patent NZ-623067-A (NZ)
Title: Retractable syringe with improved delivery efficiency and locking system
Inventor: WALLIS HUW
IPC: A61M5/178
Filed: 2010-12-10
Abstract: Disclosed are a needle assembly; retractable syringe (100) and method of making a retractable syringe (100). The disclosure notes that sharing of needles and resulting needle stick injuries can lead to exposure to infective pathogens. The present retractable syringe (100) includes a dual locking system to improve the safety of syringes. The needle assembly comprises a retractable needle (400). The retractable needle (400) comprises a cannula (410) and a needle body (420). The needle body (420) comprises one or more fluid channels whereby in use the one or more fluid channels cooperate with one or more fluid conduits of a plunger seal (800) to direct fluid to the cannula. The needle assembly further comprises a needle retainer (300) which is releasably coupled to the needle body (420) and includes a plurality of barbed arms.
Patent NZ-624699-A (NZ)
Title: Method and system for aquaculture or reducing biofouling
Inventor: JEFFS ANDREW GREIG
IPC: H04R1/44
Filed: 2013-05-07
Abstract: Attraction of sprat or larvae of target species to a substrate using sound similar to that found in a preferred environment is disclosed. This method can be used for attracting biofouling species away from ships hulls or marine structures and also for attracting aquaculture species to substrates to be further developed in controlled conditions. The use of a sacrificial member is disclosed as a preferred substrate of the bio-fouling organisms to attach to.
Patent NZ-625336-A (NZ)
Title: Method of, and apparatus for, making frozen beverages, ice cream and other frozen confections
Inventor: BUCCERI ALFIO
IPC: F25D23/06
Filed: 2013-02-22
Abstract: An apparatus for freezing liquids for consumption is described. The apparatus provides a means for converting liquids into an edible frozen or semi frozen slurry. The apparatus consists of a flexible vessel (110) whose walls contain a coolant that has a lower temperature than the liquid to be frozen and an outer container (150) to protect the users hands from the lower temperature of the vessel.
Patent NZ-627030-A (NZ)
Title: Catalysts
Inventor: VISAGIE JACOBUS LUCAS
IPC: B01J37/02
Filed: 2012-11-30
Abstract: A method of preparing a modified catalyst support is disclosed. The method comprises contacting a catalyst support material with a modifying component precursor in an impregnating liquid medium. The impregnating liquid medium comprises a mixture of water and an organic liquid solvent for the modifying component precursor, which mixture contains at least 2.5 % by volume water, but less than 12% by volume water based on the total volume of the impregnating liquid medium. The catalyst support material is selected from the group consisting of a catalyst support precursor which is convertible to a catalyst support upon calcination thereof and the catalyst support is in the form of a metal oxide which is an oxide of a metal selected from the group consisting of Al, Si, Ti, Mg, Zr and Zn; and a catalyst support selected from the group consisting of alumina in the form of one or more aluminium oxides, silica (SiO2), titania (TiO2), magnesia (MgO), zirconium oxide (ZrO2), zinc oxide (ZnO) and mixtures thereof. The modifying component precursor comprises a compound of a modifying component selected from the group consisting of Si, Zr, Ti, Cu, Zn, Mn, Ba, Ni, Al, V, W, La and mixtures of two or more thereof, thereby to obtain a modifying component containing catalyst support material. The method comprises optionally, calcining the modifying component containing catalyst support material at a temperature above 100°C to obtain a modified catalyst support. The method can further comprises preparing a modified catalyst support according to the above described method and introducing a precursor compound of an active catalyst component onto and/or into (i) the catalyst support material prior to contacting the catalyst support material with the modifying component precursor; (ii) the modifying component 30 containing catalyst support material; and/or (iii) the modified catalyst support thereby to obtain a catalyst precursor. A method of preparing a catalyst includes preparing a catalyst precursor using the above method of preparing a modified catalyst and reducing the catalyst precursor, thereby activating the catalyst precursor and obtaining the catalyst. A hydrocarbon synthesis process comprises preparing a catalyst using the above described method of preparing a catalyst and contacting hydrogen with carbon monoxide at a temperature above 100°C and a pressure of at least 10 bar with the catalyst so prepared, to produce hydrocarbons and, optionally, oxygenates of hydrocarbons.
Patent NZ-627919-A (NZ)
Title: Detection of target nucleic acid sequence by pto cleavage and extension-dependent signaling oligonucleotide hybridization assay
Inventor: LEE YOUNG JO
IPC: C12Q1/68
Filed: 2012-07-03
Abstract: Disclosed is method for detecting a target nucleic acid sequence from a DNA or a mixture of nucleic acids by a PCE-SH (PTO Cleavage and Extension-Dependent Signalling Oligonucleotide Hybridisation) assay, comprising: (a) hybridising the target nucleic acid sequence with an upstream primer and a probing and targeting oligonucleotide (PTO); wherein the upstream oligonucleotide comprises a hybridising nucleotide sequence complementary to the target nucleic acid sequence; the PTO comprises (i) a 3 - targeting portion comprising a hybridising nucleotide sequence complementary to the target nucleic acid sequence and (ii) a 5’-tagging portion comprising a nucleotide sequence non-complementary to the target nucleic acid sequence; wherein the 3’-targeting portion of the PTO is hybridised with the target nucleic acid sequence and the 5’-tagging portion is not hybridised with the target nucleic acid sequence; the upstream primeris located upstream of the PTO; (b) contacting the resultant of the step (a) to an enzyme having a 5’ nuclease activity under conditions for cleavage of the PTO; wherein the extended strand of the upstream primer induces cleavage of the PTO by the enzyme having the 5’ nuclease activity such that the cleavage releases a fragment comprising the 5’-tagging portion or a part of the 5’-tagging portion of the PTO; (c) hybridising the fragment released from the PTO with a capturing and templating oligonucleotide (CTO); wherein the CTO comprises in a 3’ to 5’ direction (i) a capturing portion comprising a nucleotide sequence complementary to the 5’-tagging portion or a part of the 5’-tagging portion of the PTO and (ii) a templating portion comprising a nucleotide sequence non-complementary to the 5’-tagging portion and the 3’-targeting portion of the PTO; wherein the fragment released from the PTO is hybridised with the capturing portion of the CTO; (d) performing an extension reaction using the resultant of the step (c) and a template-dependent nucleic acid polymerase; wherein the fragment hybridised with the capturing portion of the CTO is extended to form an extended strand comprising an extended sequence complementary to the templating portion of the CTO, thereby forming an extended duplex; (e) hybridising the extended strand with a signalling oligonucleotide (SO); wherein the SO comprises a complementary sequence to the extended strand and at least one label; the SO provides a detectable signal by hybridisation with the extended strand; and (f) detecting the signal; whereby the detection of the signal indicates the presence of the extended strand and the presence of the target nucleic acid sequence.
Patent NZ-704153-A (NZ)
Title: Novel use of alkoxylates of mono- and polyvalent alcohols
Inventor: BEDFORD MICHAEL
IPC: A61K31/08
Filed: 2013-07-12
Abstract: The present invention relates to the use of certain non-ionic surfactants, in particular alkoxylates of mono- and polyvalent alcohols, as inhibitors of methane production and/or in reducing methanogen production in vitro and/or in vivo. More specifically, the alkoxylate of a mono- or polyvalent alcohol is a compound of formula R(OC2H4)n(OH) or a mixture thereof wherein R represents a linear or branched C8-24 alkyl group; and n represents an integer from 3 to 15. Such compounds have been found to be particularly useful for methane mitigation in ruminants.
Patent NZ-705265-A (NZ)
Title: A timber-working device and method of locating at least one stem relative to a feed axis of a timber-working device
Inventor: RORY ANTONY
IPC: B27L1/00
Filed: 2015-02-25
Abstract: When processing a stem of a felled tree using a timber-working device, it is useful to centralise the stem relative to the drive mechanism of the device in order to improve effectiveness and accuracy of the device’s operation. Existing devices rely on manual control by an operator to achieve this. An automated method is provided for locating at least one stem relative to a feed axis of a frame of a timber-working device having a first pair of arms and a second pair of arms, each pivotally attached to the frame. The method includes receiving, at a controller, a signal indicating initiation of closure of the second pair of arms to grasp at least one stem currently grasped by the first pair of arms. In response to the signal indicating initiation of closure of the second pair of arms, and during closure of the second pair of arms, the first pair of arms are opened in accordance with at least one predetermined control parameter. The first pair of arms are closed once the opening of the first pair of arms has met the at least one predetermined control parameter.
Patent NZ-708758-A (NZ)
Title: Systems for delivering explosives and methods related thereto
Inventor: HALANDER JOHN B
IPC: F42D3/04
Filed: 2013-06-04
Abstract: Emulsion explosives are generally transported to a job site as an “emulsion matrix” that is too dense to completely detonate, also referred to as “unsensitized emulsion.” The emulsion matrix needs to be “sensitized” in order for the emulsion explosive to detonate successfully. Sensitizing can be accomplished by injecting chemical gassing agents into the emulsion matrix that react to form gas bubbles in the emulsion matrix. The gas bubbles reduce the density of the emulsion and make it detonable. Methods of delivering explosives with variable densities and methods of varying the energy of explosives in a blasthole are disclosed herein. The methods can include introducing at different uniform flow rates a gassing agent (21) proximal an outlet of a delivery conduit. The methods can include homogenizing the unsensitized bulk emulsion matrix (31) prior to introducing the gassing agent (21) proximal the outlet of the delivery conduit.
Patent NZ-747878-A (NZ)
Title: Povidone iodine, a novel alternative preservative for ophthalmic compositions
Inventor: LIANG BO
IPC: A01N45/00
Filed: 2009-06-10
Abstract: Disclosed herein is an stable ophthalmic composition suitable for topical administration to the eye, comprising a mixture of: (a) povidone-iodine (PVP-I) at a concentration between 0.01% and 10%, and (b) a steroid, wherein the steroid is dexamethasone sodium phosphate or dexamethasone alcohol, wherein the pH of the composition is in the range of 3 to 4. Said stable ophthalmic composition may further comprises an antimicrobial preservative selected from the group consisting of benzalkonium chloride, thimerosal, chlorobutanol, methyl paraben, propyl paraben, phenylethyl alcohol, EDTA, sorbic acid, polyquarternium 1, and any combination thereof; a viscosity increasing agent selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, methyl cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, and any combination thereof; a co-solvent/surfactant is selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, poloxamer 188, poloxamer 234, poloxamer 333, cyclodextrin, tyloxapol and a combination thereof; and artificial tears-based lubricant.
Patent NZ-751641-A (NZ)
Title: Fractal fluid passages apparatus
Inventor: Adriany Kyle
IPC: F16L41/03
Filed: 2017-09-08
Abstract: Aspects of the present disclosure include branching fluid passages in an apparatus that reduce turbulent flow and generate evenly distributed fluid pressure as the fluids branch off into the different passages. In some embodiments, the branching passages may be subdivided into two sets: the branching passages for the liquid fuel and the branching passages for the liquid oxidizer. In some embodiments, the two sets of passages are carefully designed in an elegant yet extremely intricate manner that is optimized for proper fluid flow and maximal burn efficiency. The ends of all of the passages meet at the injector interface, which dispense the liquids into the combustion chamber for ignition. Generally, these designs are achieved through additive manufacturing, and would be extremely difficult, if not impossible, to be manufactured using traditional techniques.
Patent NZ-759766-A (NZ)
Title: Use of lactic acid bacteria to treat or prevent at least one of postnatal depression and postnatal anxiety
Inventor: SLYKERMAN REBECCA
IPC: A61P25/24
Filed: 2017-06-02
Abstract: The present invention provides methods of treating or preventing at least one of postnatal depression (PND) and postnatal anxiety (PNA), and risks and sequelae thereof, by administering Lactobacillus rhamnosusHN001 or derivatives thereof, in addition to uses, compositions, and medicaments comprising Lactobacillus rhamnosusHN001 or derivatives thereof to treat or prevent at least one of PND and PNA, and risks and sequelae thereof.