Patent SG-11201811686U-A (SG)
Title: 18f-labeled triazole containing psma inhibitors
Inventor: BABICH JOHN
IPC: C07C275/16
Filed: 2017-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 0 11101 HOE 3E1 0 01111011111110111010111111110 III OEN Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/005625 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: (74) Agent: MEARA, Joseph, P. et al.; Foley & Lardner LLP, A61K 51/04 (2006.01) CO7C 275/16 (2006.01) 3000 K Street N. W., Suite 600, Washington, District of Co- C07B 59/00 (2006.01) lumbia 20007 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/039710 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 28 June 2017 (28.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/355,430 28 June 2016 (28.06.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: CORNELL UNIVERSITY [US/US]; Center for Technology Licensing (CTL), 395 Pine Tree Road, Suite (84) Designated States (unless otherwise indicated, for every 310, Ithaca, New York 14850 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — (72) Inventors: BABICH, John, W.; 500 E. 83rd Street, Apt. UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 10C, New York, New York 10028 (US). KELLY, James, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, M.; c/o Cornell University, CTL, 395 Pine Tree Road, Suite EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 310, Ithaca, New York 14850 (US). AMOR-COARASA, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Alejandro; c/o Cornell University, CTL, 395 Pine Tree TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Road, Suite 310, Ithaca, New York 14850 (US). PON-KM, ML, MR, NE, SN, TD, TG). = = NALA, Shashikanth; c/o Cornell University, CTL, 395 — Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). = (54) 18 F Title: -LABELED TRIAZOLE CONTAINING PSMA INHIBITORS (57) : The present technology is directed to compounds, intermediates EIGURE I - _ thereof, compositions thereof, medicaments thereof, and methods related to the 1 imaging of mammalian tissue overexpressing PSMA. The compounds are of For- mula (I) or a pharmaceutically acceptable salt thereof, wherein one of R 1 , R , and 2 = R 3 is, and of Formula (IV) or a pharmaceutically acceptable salt thereof. = _ = — _ = = = = = = ' Il ir) ei , ir) / U Y © © ---.... Il © ei C [Continued on next page] WO 2018/005625 Al MIDEDIMOMMIDEFIEHVIIMEMOHMEHOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of