baber/WOPTO huggingface dataset:
Patent CA-3134782-A1 (CA)
Inventor: BOUCH SHEENA
IPC: C12N5/071
Filed: 2020-03-27
Abstract: A method of differentiating pluripotent stem cells into hemangioblasts comprising incubating the pluripotent stem cells in a first serum-free differentiation medium comprising bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor (VEGF) and stem cell factor (SCF) to induce differentiation of the pluripotent stem cells into hemangioblasts or hemangioblast-containing embryoid bodies is provided. The hemangioblasts or embryoid bodies may be cultured in a second differentiation medium comprising at least granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage colony stimulating factor (M-CSF) and interleukin-3 (IL-3) for a period of time sufficient to generate alveolar-like macrophages.
Patent CA-3135223-A1 (CA)
Inventor: BUKHAMSEEN AHMED
IPC: E21B47/10
Filed: 2020-04-09
Abstract: Provided is a method for the determination of the water cut and volumetric flow rate of a fluid flowing through a density inflow control valve (102). A density inflow control valve (102) may include a floating device (204) that moves between a relaxed choke position and a restricted choke position depending on the density of the fluid flowing through the valve. Pressure gauges upstream and downstream of the inflow control device may be used to measure the pressure drop across the inflow control valve over time. The water cut of the downhole fluid flowing through the valve may be determined from the pressure drop over time and the pressure drop associated with the relaxed choke position and the restricted choke position. The volumetric flow rate may be determined from the average water cut and the density of the downhole fluid, as determined from the single phase densities.
Patent CA-3135619-A1 (CA)
Inventor: MENDEZ PEDRO
IPC: C12Q1/6834
Filed: 2020-04-02
Abstract: Provided herein are methods for detection and characterization of a target nucleic acid from a single cell. Some embodiments highlight the capability of identifying the biologically relevant variants at the moment of the diagnosis, but also how the treatment positively select resistant cellular clones based on the mutation signature. This positions the Tapestri platform described herein as the only tool available to study how genetic variants co-exist and which combinations are sensitive and resistant to certain treatments. Thus, it helps in the diagnostic precision, treatment follow up and new target identification and drug development
Patent CA-3136075-A1 (CA)
Inventor: DALE RICHARD
IPC: C07D405/12
Filed: 2020-05-19
Abstract: La présente invention concerne, entre autres, des procédés et des compositions pour lutter contre les mauvaises herbes, par exemple, un procédé de lutte sélective contre les mauvaises herbes au niveau d'un lieu comprenant des plantes cultivées et des mauvaises herbes par application au lieu d'une quantité de lutte contre les mauvaises herbes d'une composition pesticide comprenant un herbicide inhibant la SDPS, les plantes cultivées étant modifiées de sorte qu'elles comprennent une SDPS qui fournit à la plante cultivée une tolérance vis-à-vis de l'herbicide inhibant la SPDS. Les compositions comprennent également, entre autres, des polynucléotides recombinés appropriés pour être utilisés dans les procédés.
Patent CA-3138071-A1 (CA)
Title: Formulations and doses of pegylated uricase
Inventor: JOHNSTON LLOYD
IPC: A61P19/06
Filed: 2020-06-04
Abstract: Provided herein are methods and compositions and kits related to identification and/or treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout, and for preventing gout flare.
Patent CA-3138461-A1 (CA)
Title: Vaccine adjuvants based on tlr receptor ligands
Inventor: BAZIN-LEE HELENE
IPC: A61K39/145
Filed: 2020-05-22
Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.
Patent CA-3139688-A1 (CA)
Inventor: CIANA PAOLO
IPC: A61K49/00
Filed: 2020-05-29
Abstract: La présente invention concerne l'utilisation de vésicules extracellulaires isolées du plasma de patients oncologiques pour administrer sélectivement des médicaments thérapeutiques ou diagnostiques.
Patent CA-3139774-A1 (CA)
Title: Determining a motion zone for a location of motion detected by wireless signals
Inventor: DEVISON STEPHEN ARNOLD
IPC: G01S11/00
Filed: 2019-08-28
Abstract: In a general aspect, a method is presented for determining a motion zone for a location of motion detected by wireless signals. In some aspects, the method includes obtaining a time series of statistical parameters derived from sets of channel response data. The method also includes identifying time intervals in the time series of statistical parameters, each time interval associated with a respective motion zone in the space. The method additionally includes determining, by analyzing multiple time windows within each of the time intervals, ranges of motion-zone parameters associated with each respective motion zone. The method further includes storing, in a database of a motion detection system, the ranges of motion-zone parameters for the respective motion zones. The ranges of motion-zone parameters are used to identify one of the motion zones based on a motion event detected by the motion detection system.
Patent CA-3140626-A1 (CA)
Inventor: ZHENG PENG
IPC: A61B8/00
Filed: 2019-05-31
Abstract: In one aspect, a system for endovascular treatment of a blood vessel includes a control unit, an ultrasound device, an actuator, and a catheter having a treatment portion. The ultrasound device is communicatively coupled to the control unit. The ultrasound device includes an ultrasound probe having a subject contact surface. The actuator is coupled to the ultrasound probe and is operable to move the subject contact surface of the ultrasound prove relative to a treatment zone of a subject. The control unit is configured to determine a position of the treatment portion of the catheter as the catheter is advanced through the blood vessel, and move the subject contact surface of the ultrasound probe relative to the treatment zone of the subject with the actuator to follow the position of the catheter as the catheter is advanced through the blood vessel.
Patent CA-3142733-A1 (CA)
Title: Methods for manufacturing t cells by direct sorting and compositions thereof
Inventor: ALPERT AMIR
IPC: G01N15/14
Filed: 2020-06-05
Abstract: Described herein are methods for preparing T cells, including isolating CD8+ T cells from a blood sample obtained from a patient or a donor, culturing the isolated CD8+ T cells in the presence of at least one cytokine, contacting the cultured CD8+ T cells with a multimer containing a target peptide in a complex with an MHC molecule and with at least one binding agent that binds to a T cell surface molecule, in which the multimer is labelled with a first detectable agent and the binding agent is labelled with a second detectable agent, sorting the contacted CD8+ T cells to collect the sorted CD8+ T cells that are detected positive for the first and the second detectable agents, and expanding the collected CD8+ T cells.
Patent CA-3143418-A1 (CA)
Title: Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
Inventor: HORTON HELEN
IPC: A61K39/395
Filed: 2020-06-18
Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an RNAi agent for inhibiting the expression of an HBV gene are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
Patent CA-3143422-A1 (CA)
Title: System for cultivating plants and operation method thereof
Inventor: ALESSIO ANDREA
IPC: A01G31/06
Filed: 2020-06-19
Abstract: A system for cultivating plants (1) comprising a plurality of cultivation shelves (4) for cultivating plants, support frames (3) structured to support the cultivation shelves (4) so as to form one or more horizontal cultivation planes (Li) that develop along a first horizontal direction (K), an aeroponic feeding system (6), which is provided with nebulizing devices (8) that are arranged at the cultivation shelves (4) for spraying the liquid towards the cultivation shelves (4) themselves, and a suction duct (15) arranged at the nebulizing devices (8) to suck up the nebulised liquid dispersed by the same.
Patent CA-3146429-A1 (CA)
Title: Procede de fabrication d'etiquettes de spectroscopie raman exaltee de surface
Inventor: PIOTTI MARCELO EDUARDO
IPC: B82Y20/00
Filed: 2020-07-13
Abstract: La présente invention concerne le domaine des procédés de fabrication d'étiquettes de spectroscopie Raman exaltée de surface (SERS). Le procédé de fabrication selon la présente invention est reproductible et polyvalent et permet la production de manière opportune de quantités élevées d'étiquettes SERS caractérisées par une distribution de taille étroite et un rapport élevé d'agrégats à faibles nombres de nanoparticules. Les étiquettes SERS fabriquées selon le procédé de fabrication de l'invention permettent d'obtenir des réponses SERS d'ensemble accrues.
Patent CA-3152835-A1 (CA)
Inventor: WANG FUPING
IPC: G06F16/28
Filed: 2020-06-24
Abstract: La présente invention se rapporte à un procédé et à un appareil de traitement de données de dimension, à un dispositif informatique et à un support de stockage. Le procédé comprend les étapes consistant à : acquérir une table de dimension cible d'un entrepôt de données ; configurer, selon des informations d'attribut de dimension prédéfinie, un paramètre de dimension de la table de dimension cible de façon à obtenir des premières données de dimension ; configurer, selon des informations d'attribut de table de dimension prédéfinie, un paramètre de table de données de la table de dimension cible de façon à obtenir des secondes données de dimension ; et configurer, selon les premières données de dimension et les secondes données de dimension de la table de dimension cible, des services de données correspondant à la table de dimension cible, les services de données comprenant un premier service de données créé selon les premières données de dimension et un second service de données créé selon les secondes données de dimension. Le procédé peut être utilisé pour effectuer une gestion de données et un traitement de données sur des données de dimension d'entrepôts de données.
Patent CA-3156920-A1 (CA)
Title: Rod pumping surface unit
Inventor: KRUG DAVID A
IPC: E21B43/12
Filed: 2022-04-21
Abstract: An oil well pumping unit. The pumping unit has a vertical support column residing adjacent a horizontal support base at a generally transverse orientation. The pumping unit has a standing sheave fixed proximate an upper end of the vertical support column, a carrier bar configured to be attached to a polished rod along the front face of the vertical support column, and a traveling sheave configured to move up and down along the vertical support column. A near-vertical actuator resides along the horizontal support base, and is connected to the traveling sheave. Cyclical movement of the linear actuator causes the traveling sheave to reciprocate up and down along the vertical support column such that upward movement of the traveling sheave produces a downstroke of the polished rod, while downward movement of the traveling sheave produces an upstroke of the polished rod. The linear actuator remains in tension at all times during movement of the polished rod.
Patent CA-3156921-A1 (CA)
Inventor: KNOBLOCH GESINE
IPC: A61B5/055
Filed: 2020-10-05
Abstract: La présente invention concerne la génération d'images IRM artificielles du foie. L'invention concerne également un procédé, un système et un produit programme d'ordinateur pour générer des images IRM du foie sans amélioration du contraste.
Patent CA-3157802-A1 (CA)
Inventor: PLUMER NICHOLAS
IPC: E01H5/07
Filed: 2020-10-12
Abstract: L'invention concerne un appareil de déneigement et un procédé associé de déneigement d'une surface sous-jacente. L'appareil comprend une pale de chasse-neige conçue pour se trouver à distance de la surface sous-jacente lorsque l'appareil est en cours d'utilisation, une première unité de transport d'air servant à distribuer de l'air forcé dans une chambre de distribution d'air de pale et une seconde unité de transport d'air servant à distribuer de l'air forcé à un jet à vide à effet Venturi. La chambre de distribution d'air de pale est conçue pour distribuer de l'air à la surface sous-jacente de façon à soulever la neige située sur cette dernière. Le jet à vide à effet Venturi est conçu pour pousser l'air et la neige soulevée dans et à travers une goulotte de collecte. L'utilisation de l'appareil donne une route plus propre qui permet, par passage, une vitesse plus élevée sans nécessiter l'utilisation de sel et/ou de sable et sensiblement moins d'usure et de détérioration de la route.
Patent CA-3158083-A1 (CA)
Inventor: AUGIER FREDERIC
IPC: B01J19/24
Filed: 2020-12-08
Abstract: La présente invention concerne un réacteur gaz/liquide d'oligomérisation à zones successives de diamètre variable. L'invention concerne également un procédé d'oligomérisation de l'éthylène mettant en ?uvre un réacteur gaz/liquide d'oligomérisation à zones successives de diamètre variable.
Patent CA-3158721-A1 (CA)
Inventor: GAMET OLIVIER
IPC: C04B26/26
Filed: 2020-12-18
Abstract: The present invention relates to a pitch composition comprising a mixture of: - de-asphalting pitch which represents at least 50 wt%, preferably at least 80 wt%, most preferably at least 90 wt% of the total weight of the composition; and - a hydroxide XOH, where X = Na or K, which represents 0.001 to 1 wt% of the total weight of the composition. The invention also relates to a process for the preparation of said pitch composition as well as to the uses thereof, in particular in the field of road construction.
Patent CA-3159426-A1 (CA)
Title: Structure textile a base de fibres de verre avec revetement parylene
Inventor: GARNIER LOUIS
IPC: C03C25/32
Filed: 2020-12-14
Abstract: L'invention concerne une structure textile à base de fibres de verre, caractérisée par le fait qu'elle porte un revêtement de parylène (poly(para-xylylène)) ayant une épaisseur comprise entre 5 µm et 30 µm, de préférence entre 6 µm et 25 µm, en particulier entre 7 et 20 µm. Elle concerne également un procédé de renforcement d'un matériau solide, comprenant l'introduction d'une telle structure textile portant un revêtement de parylène dans un matériau de base fluide, de préférence un matériau de base comprenant de l'eau et un liant hydraulique, et le durcissement du matériau de base
Patent CA-3163904-A1 (CA)
Inventor: ANTYSHEVA ZOIA
IPC: G16B20/00
Filed: 2020-12-05
Abstract: Techniques for determining one or more characteristics of a biological sample using rankings of gene expression levels in expression data obtained using one or more sequencing platforms is described. The techniques may include obtaining expression data for a biological sample of a subject. The techniques further include ranking genes in a set of genes based on their expression levels in the expression data to obtain a gene ranking and determining using the gene ranking and a statistical model, one or more characteristics of the biological sample.
Patent CA-3169063-A1 (CA)
Title: Polypeptides et vecteurs capsidiques de virus adeno-associes
Inventor: LISOWSKI LESZEK
IPC: C12N7/00
Filed: 2021-02-25
Abstract: La présente divulgation concerne d'une manière générale des polypeptides capsidiques de virus adéno-associés (VAA) et des molécules d'acide nucléique codantes. La divulgation concerne également des vecteurs de VAA comprenant les polypeptides capsidiques, et des vecteurs d'acide nucléique (par exemple, des plasmides) comprenant les molécules d'acides nucléiques codantes, ainsi que des cellules hôtes comprenant les vecteurs. La divulgation concerne en outre des procédés et des utilisations des polypeptides, des molécules d'acides nucléiques codantes, des vecteurs et des cellules hôtes.
Patent CA-3169650-A1 (CA)
Title: Aircraft with pusher propeller
Inventor: TIGHE JAMES JOSEPH
IPC: B64C27/22
Filed: 2021-02-10
Abstract: Embodiments provide an electric aircraft with a plurality of lift fan assemblies that are configured to provide vertical lift, and one or more pusher propellers that are configured to provide forward thrust. The lift fan assemblies may be coupled to the wings of the aircraft via one or more support structures, and the wings may be coupled to an upper region of the fuselage. The pusher propeller(s) may be coupled to a tailing end of the fuselage. The lift fan assemblies and the pusher propeller(s) may provide thrust and movement in directions that are orthogonal to one another. A control system coupled to the aircraft may control the lift fan assemblies and the one or more pusher propellers to activate, increase in power, and decrease in power. The lift fan assemblies and the one or more pusher propellers may be operated separately, and may be active at different times.
Patent CA-3169709-A1 (CA)
Inventor: REYNOLDS DOMINIC
IPC: A61K31/437
Filed: 2021-02-28
Abstract: The present disclosure features compounds of formula (l-a) and related compositions that, inter alia, modulate nucleic acid splicing e.g., splicing of a pre-mRNA, as well as methods of use thereof.
Patent CA-3169867-A1 (CA)
Inventor: SHUTE NEIL ALEXANDER
IPC: G07D11/125
Filed: 2021-02-15
Abstract: Apparatus for securely retaining documents, the apparatus (1) comprises a cover plate (4) and a receptacle (10), the receptacle (10) comprising a frame (3) and a pouch (2), the frame (3) comprising an opening (O) to access the pouch (2), the frame (3) further comprises at 5 least one channel (31a, 31b) for receiving an edge (4c, 4d) of the cover plate (4) in use to cover the opening (O) of the frame (3) and to prevent access to the interior of the pouch (2) of the receptacle (10) when the cover plate (4) is in a closed position, wherein the frame (3) and the cover plate (4) each comprise engageable lock portions to prevent the cover plate (4) from being removed from the receptacle (10) when in the closed position, and wherein 10 the frame (3) comprises a first formation (32a, 32b) located remotely from the at least one channel (31a, 31b) located between the at least one channel (31a, 31b) and the opening, the cover plate (4) comprises a second formation (42a, 42b) located remotely from the edge (4c, 4d) of the cover plate (4), the first formation (32a, 32b) and second formation (42a, 42b) are shaped to interlock to resist removal of the cover plate (4) in a direction transverse 15 and/or perpendicular to the major surface of the cover plate (4).
Patent CA-3170040-A1 (CA)
Inventor: BELL JULIAN LELAND
IPC: B07C3/02
Filed: 2021-03-31
Abstract: A multi-tiered automated parcel sortation system is utilized to sort parcels according to a common destination. A first tier includes an automated sorter configured to transport parcels from a source location to a release destination. A second tier includes accumulation containers each associated with a shipping destination, and the release destination within the first tier is a positioned directly above the accumulation container associated with the shipping destination of the parcel. Once transported to the release destination, a parcel is released into the accumulation container, and once the accumulation container is filled, the accumulation of parcels within the container is released into a third tier, which may include conveyors or autonomous guided vehicles with transport containers. In the third tier, the parcels are transported away for further processing.
Patent CA-3170170-A1 (CA)
Inventor: MAEDA AYAKO
IPC: A23D9/00
Filed: 2021-02-12
Abstract: L'invention fournit un agent diminuant le caractère huileux qui permet de diminuer le caractère huileux perçu par une personne lorsqu'elle consomme un aliment. L'agent diminuant le caractère huileux de l'invention est caractéristique en ce qu'il comprend en tant que principe actif une huile brute contenant une huile pressée d'une matière de départ d'huile ou graisse ou une huile extraite de ladite matière de départ d'huile ou graisse, ou une huile chauffée telle qu'un traitement thermique à 120°C ou plus est exécuté sur une huile ou une graisse via un processus de démucilagination, un processus de désacidification ou un processus de décoloration, lors d'un processus de raffinage de ladite huile brute.
Patent CA-3172802-A1 (CA)
Title: Interrupt handling
Inventor: LAHAV ELAD
IPC: G06F15/16
Filed: 2022-09-07
Abstract: In some examples, a system includes one or more hardware processors, an interrupt service thread to handle an interrupt, and a kernel scheduler to schedule the interrupt service thread as part of a collection of threads to be scheduled.
Patent CA-3176257-A1 (CA)
Inventor: CAMPBELL MARY
IPC: A61K39/395
Filed: 2021-03-25
Abstract: Provided herein are methods of treating multiple myeloma (MM) using specific doses of an anti-B-cell migration antigen (BCMA) antibody, various dosing regimens, and optionally combination therapy with dexamethasone, an immunomodulatory agent (e.g., pomalinamide), an anti-CD38 antibody or antigen binding fragment thereof (e.g., daratumumab), and a gamma secretase inhibitor (GSI), and/or various combinations thereof.
Patent CA-3176393-A1 (CA)
Inventor: JENSEN PETER RUHDAL
IPC: C12P19/02
Filed: 2021-05-25
Abstract: L'invention concerne un catalyseur à cellules entières perméabilisées et un procédé de conversion (réduction de la quantité) d'un substrat cible à un ou plusieurs produits, le catalyseur étant obtenu par incubation des cellules avec un agent de perméabilisation choisi parmi un acide gras et un dérivé d'acide gras, et les cellules perméabilisées comprenant une enzyme intracellulaire pour catalyser la conversion du substrat cible. Le substrat cible transite à travers le canal, des trous ou des pores formés dans la membrane cellulaire par l'agent de perméabilisation, et est converti en produits par des enzymes retenues à l'intérieur de la cellule.
Patent CA-3176902-A1 (CA)
Inventor: SALLBERG MATTI
IPC: A61P31/14
Filed: 2021-03-24
Abstract: L'invention concerne des compositions immunogènes ou des combinaisons de produits d'acides nucléiques du SARS-CoV modifié, des gènes, des peptides ou des protéines aptes à être utilisés pour induire une réponse immunitaire contre une infection par le SARS-CoV ou une infection par un autre coronavirus, y compris le SARS-CoV -2 et des variants de ce dernier. L'invention concerne également des procédés d'utilisation des compositions immunogènes ou des combinaisons de produits chez des sujets pour générer des réponses immunitaires et neutraliser les anticorps dirigés contre SARS.CoV ou un autre coronavirus par l'administration des compositions ou combinaisons avec une approche d'amorce d'amplification d'acide nucléique et de polypeptide.
Patent CA-3176910-A1 (CA)
Title: Light display systems
Inventor: JEROMIN AARON
IPC: G02B27/01
Filed: 2021-05-06
Abstract: A light display system may display an image to a user and/or an audience using a persistence of vision effect. In an embodiment, a light display system includes a light source configured to emit a plurality of light patterns that correspond to multiple frames of an image. The light source is configured to sequentially emit the plurality of light patterns based on instructions from a control system such that the multiple frames are presented in a sequence at a first rate. The light display system also includes an image expander configured to reflect the plurality of light patterns toward a user of the head-mounted device, wherein at least a portion of the image expander is configured to rotate relative to the light source at a second rate that is coordinated with the first rate by the control system to thereby display the image for visualization by the user.