Patent SG-11201910191R-A (SG)
Title: A peptide capable of forming a gel for use in tissue engineering and bioprinting
Inventor: -
IPC: C07K5/113
Filed: 2018-03-29
Abstract: 1 Cr) O N O 00 1-1 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT Hu omit °nolo oi mom oimIE (10) International Publication Number WO 2018/207036 Al (51) International Patent Classification: C07K 5/11 (2006.01) A61L 27/38 (2006.01) CO7K 5/103 (2006.01) A61L 27/50 (2006.01) CO7K 5/113 (2006.01) A61L 27/52 (2006.01) CO7K 5/107 (2006.01) A61L 27/54 (2006.01) A61K 38/07 (2006.01) (21) International Application Number: PCT/IB2018/052173 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,976 11 May 2017 (11.05.2017) US (71) Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY [SA/SA]; 4700 King Abdullah University of Science and Technology, Thuwal, 23955-6900 (SA). (72) Inventor: HAUSER, Charlotte, A.E.; King Abdullah Uni- versity of Science and Technology, Division of Biologi- cal & Environmental Science & Engineering, Laboratory for Nanomedicine, Al-Haytham Building (Bldg. 2), Office 4217, Thuwal, 23955-6900 (SA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: A PEPTIDE CAPABLE OF FORMING A GEL FOR USE IN TISSUE ENGINEERING AND BIOPRINTING Figure 1 A Add Water to Peptide ) 900 uf Wdter mr .\" Vortex lip irt Add 10x PBS (1:10) lox (57) : The present invention relates to peptides capable of forming a gel and to their use in tissue engineering and bioprinting. The present invention furthermore relates to a gel comprising a peptide in accordance with the present invention, to a method of preparing such gel and to the use of such gel. In one embodiment, such gel is a hydrogel. The present invention furthermore relates to a wound dressing or wound healing agent comprising a gel according to the present invention and to a surgical implant or stent comprising a peptide scaffold formed by a gel according to the present invention. Moreover, the present invention also relates to a pharmaceutical and/or cosmetic composition, to a biomedical device or an electronic device comprising the peptide according to the present invention. [Continued on next page] WO 2018/207036 Al IIIIIIIIIIIIIIIIIIIIIIDEIIIIIIIH IIIIII0101IIIIIIIIIIIIIIIIIIIIIIIIIIIIIII VOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))