baber/WOPTO huggingface dataset:
Patent SI-1893620-T1 (SI)
Title: Substituted spiro compounds and their use for producing pain-relief drugs
Inventor: SCHICK HANS
IPC: A61K31/00
Filed: 2006-05-17
Abstract: Substituted spiro-compounds (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. Substituted spiro-compounds of formula (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. m : 0-4; n : 0-2; R 1>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued); either R 2>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued); and R 3>e.g. H or optionally substituted aliphatic compound; or NR 2>R 3>e.g. optionally substituted cycloaliphatic group; R 4>e.g. halo, NO 2 or CN; R 5>e.g. H, halo, NO 2, CN or amino; R 6>, R 8>e.g. optionally substituted (cyclo)aliphatic compound; R 7>, R 9>e.g. H, optionally substituted aliphatic compound or optionally substituted cycloaliphatic group; and R 10>-R 25>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued). Full Definitions are given in the DEFINITIONS (Full Definitions) Field. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Analgesic; Antimigraine; Antidepressant; Neuroprotective; Nootropic; Antiparkinsonian; Anticonvulsant; Respiratory-Gen.; Antiasthmatic; Antiinflammatory; Antitussive; Uropathic; Gastrointestinal-Gen.; Cerebroprotective; Vasotropic; Dermatological; Antidiarrheic; Antipruritic; Eating-Disorders-Gen.; Immunomodulator; Anabolic; Anorectic; Antiaddictive; Cardiovascular-Gen.; Muscular-Gen.; Tranquilizer; Hypotensive. MECHANISM OF ACTION : Vanilloid receptor-1 agonist.
Patent SI-2022788-T1 (SI)
Title: NOVEL CRYSTAL OF 3-?á5-?á4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL?å-2-?á(3-HYDROXY-1,2-BENZISOXAZOL-6-YL)METHOXY?åPHENYL?åPROPIONIC ACID
Inventor: YONEZAWA KENJI
IPC: A61K31/00
Filed: 2007-05-25
Abstract: The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3°and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2¸ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.
Patent SI-2858830-T1 (SI)
Title: Omnidirectional wheel
Inventor: OHRUH MICHEL
IPC: B60B19/00
Filed: 2013-06-12
Abstract: The present invention relates to an omnidirectional wheel (1), comprising a central hub (2) on which a tread (3), consisting of the juxtaposition of wheels or sleeves arranged along radial planes, is peripherally mounted. The omnidirectional wheel (1) according to the invention comprises spokes (5, 51) which are connected, two-by-two, via a shaft section (6) which is coaxial to the hub (2), which has a round cross-section, and onto which freely rotatable rings (4) are fitted, said shaft section (6) further comprising struts (7) inserted between each of said rings (4), said struts (7) being shaped such that said rings (4) remain in a radial position, said shaft section (6) consisting of a series of a plurality of abutting tubular segments (61, 62, 63, 64, 65). The invention further relates to a module (10) for assembling an omnidirectional wheel (1) according to the invention.
Patent SI-2820009-T1 (SI)
Title: Serine/threonine kinase inhibitors
Inventor: BLAKE JAMES F
IPC: C07F9/00
Filed: 2013-03-01
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Patent DE-3486177-T2 (DE)
Inventor: MILLER RONALD B
IPC: A61K31/74
Filed: 1984-12-07
Granted: 1994-03-10
Abstract: Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve anti hypertension is insufficient to achieve diuresis. Such administration in a non-diuretic amount is effected in 4-8 consecutive hourly doses to achieve reduction of blood pressure without high urine output. The invention further relates to complexes of thiazides with mixed cation-anion exchange resins, to insoluble basic metal hydroxy thiazide salts, the salts of thiazide with calcium disodium edetate or disodium edetate, to molecular complexes of thiazides with long chain polymers such as hydroxy alkyl cellulose polymers, carboxy methyl cellulose and polyvinylpyrrolidone, to beta-adrenergic blocking amine-thiazide salts and to amiloride thiazide salts.
Patent DE-3688142-T2 (DE)
Inventor: GROPPER ADRIAN
IPC: G01N27/26
Filed: 1986-01-22
Granted: 1993-07-22
Abstract: Apparatus (10) for measuring or detecting a chemical entity in a liquid sample, the apparatus including a first module (12) operationally connected to a second module (14), the first module having a flow passage for the sample, the flow passage including a sensor (49) for measuring or detecting the chemical entity and pump means (34) for advancing the sample along the flow passage, the second module including means for actuating the pump means, and the second module being connected to the first module via connecting means permitting disconnection of the first and second modules and connection of a replacement first module to the second module.
Patent DE-3779488-T2 (DE)
Inventor: DENEV MARTIN
IPC: H02K33/00
Filed: 1987-03-16
Granted: 1993-01-07
Abstract: The invention belongs to the areas energy technology and methods for transformation of the energy of permanent magnets (from the rotation of the electrones around the parallel atom axises of the permanent magnets) to mechanic energy. The method solves the technical problems to create screen of active type, which can screen magnetic fields, at the samt time screen which does not itself be acctracted or repelled by magnetic field. Other materials screening magnetic fields without themselves being attracted or repelled by the magnetic field do not exist. Iron for example screens the magnetic field but is itself attracted by the magnetic field and in order to pull the iron from the magnet is energy using needed. Martin Denev's method is solving this problem by building permanent magnet structures similar to the chromosomes and nervous system in living organisms, since living organisms have built structures that can both screen magnetic field and the living system is not attracted or repelled by outer magnetic field, even in case of that iron is included in the living system. Only such a chromosome-like permanent magnet structure can build a screen under which protection one can situate against each other two same poles of permanent magnets, which after taking away of the screen can perform work. This cycle can be repeated as much as wanted, in a motor,which transforms the magnetic energy to mechanic. This is no perpetum mobile, since the magnetic energy has its origin in the permanently rotating electrones, and the energy is all the time supplied in the system. In perpetum mobile machines no energy is supplied all the time during the work.
Patent DE-3782073-T2 (DE)
Inventor: TJOENG FOE SIONG
IPC: C07K1/10
Filed: 1987-03-26
Granted: 1993-05-06
Abstract: Novel synthetic atrial peptides are provided with enhanced natriuretic properties by substituting one or two arginine residues for the N-terminal ser-ser in atriopeptins I, II and III and their physiologically acceptable salts, esters and amides.
Patent DE-3789170-T2 (DE)
Inventor: BORNHORST JAMES M
IPC: F21V21/30
Filed: 1987-04-28
Granted: 1994-06-01
Abstract: A stage light instrument for providing efficient cooling of electrical components (40, 42) and a high wattage lamp (101). The facility includes a base enclosure (10) and a lamp enclosure (22) joined for pan and tilt movements by a forked hollow connecting member (14). The cylinder part (36) of the connecting member (14) is apertured and encased within the base enclosure (10) in bearings (65, 66) and in a plenum (34). A pair of tubes (68, 70) each with an air passage (72, 74) corporate with bearings (69, 71) to join the arms (18, 20) of the forked connecting member (14) to the lamp enclosure to provide air passage from the base enclosure (10) to the lamp enclosure (22). A fan (12) mounted in the base enclosure (10) draws air over electrical components (40, 42) and forces the air into the forked connecting member (14). Air is the routed through various ducts (86, 88, 98), hoods (120) and baffles (122) onto the high wattage lamp (101) and other lamp apparatus (90,92, 112) housed within the lamp enclosure for cooling.
Patent DE-3873962-T2 (DE)
Inventor: SOEDERBERG PER OLOF
IPC: A61C8/00
Filed: 1988-04-19
Granted: 1993-03-18
Abstract: A dental bridge (1) is described made of gold alloy and provided with sockets (2, 13) cast thereinto, through which sockets the bridge will be attached to anchoring elements (9, 10) attached to the jaw-bone of a patient. What is new is the sockets (2, 13) comprising a supporting part (3, 14) made of titanium, the outer surface of said supporting part being provided with retention means (5, 6, 15) for locking of the socket against axial movement. A manner of preparation of a such dental bridge and a socket (2, 13) being a means for carrying out the manner are also described.
Patent DE-3878017-T2 (DE)
Inventor: VELDHUIS RAYMOND NICOLAAS JOHA
IPC: G11B20/10
Filed: 1988-04-20
Granted: 1993-07-22
Abstract: A system for subband coding of a digital audio signal x(k) includes in the coder (1) a filter bank (3) for splitting the audio signal band, with sampling rate reduction, into subbands (p = 1, ....P) of approximately critical bandwidth and in the decoder (2) a filter bank (5) for merging these subbands, with sampling rate increase. For each subband (p) the coder (1) comprises a detector (7(p)) for determining a parameter G(p;m) representative of the signal level in a block (p;m) of M samples of the subband signal xp(k) as well as a quantizer (8(p)) for adaptively block quantizing this subband signal in response to parameter G(p;m), and the decoder (2) comprises a dequantizer (9(p)) for adaptively block dequantizing the quantized subband signal sp(k)in response to parameter G(p;m). The quantizing characteristics are related to the noise-masking curve of the human auditory system, owing to which a high-quality of the replica x/< ANd >(k) of audio signal x(k) is attained with an average number of approximately 2.5 bits per sample for representing the output signals of the coder (1). The occasional audibility of quantizing noise in this replica x/< ANd >(k) is reduced effectively in that the coder (1) and decoder (2) contain identical bit allocation means (23, 24) responsive to a set of parameters G(p;m) for the higher group of subbands (pim</=p</=P) within an allocation window (Fig. 5) for allocating a number of B(p;m) bits per sample from a fixed predetermined number of B bits for this allocation window to the quantizer (8(p)) and the dequantizer (9(p)) for the block (p;m) of subband signal xp(k) and sp(k), respectively.
Patent DE-3878691-T2 (DE)
Inventor: LYNN D
IPC: C22B7/00
Filed: 1988-06-09
Granted: 1993-06-09
Abstract: A calcium-alumino-silicate composition comprising the reaction product of electric arc furnace dust and/or an aqueous chemical waste sludge including a source of ferrous ions and selective additive materials, the additive materials are selected so that the total composition of the additive ingredients and said sludge includes fly ash, electric arc furnace dust, lime kiln dust, ferrous sulfate, hydrated lime to provide an alkalinity of about 9 to 9.5% and water, the composition contains at least 0.2% by weight of ferrous ions and is hardenable through chemical reactions, the product of which includes calcium-alumino-silicates.
Patent DE-3883204-T2 (DE)
Inventor: POLTASH LAWRENCE M
IPC: A44C25/00
Filed: 1988-06-16
Granted: 1994-03-03
Abstract: The present invention relates to a method of making a costume jewelry equivalent of jewelry bearing colored leaves and grapes on its surface. The method involves the forming of a brass base and ornaments both being formed with connecting parts for easy assemblage. The connecting parts comprise studs and corresponding openings. The base is plated in gold. The ornaments are etched and plated in a gold alloy, and the ornaments and base are then connected together.
Patent DE-3889617-T2 (DE)
Inventor: HUNTER BILL D
IPC: B24B13/02
Filed: 1988-06-03
Granted: 1994-10-20
Abstract: A toric finer-polisher (10) for the fining and/or polishing of a toric lens comprises a lap table (36) for holding a tool, a spindle (48) on which the lap table (36) is mounted, a rocker arm assembly (18) for holding the lens in contact with the tool, and a motor for driving the spindle (48) and lap table (36) so as to cause relative motion between the tool and the lens, thereby finishing the surface of the lens. The spindle (48) is fixed at its lower end to a gimbal, and is contacted at an intermediate point along the spindle (48) by a timing belt (44) connected to the motor, so as to maximize a gimbal radius of the lap table (36) assembly, thus maintaining a parallel relationship between the tool axis and the lens axis during finishing of the lens surface. Other features of the invention include provision of all motions (rotational, orbital and transverse) by a single motor, provision of a two-spindle arrangement in which dual spindles are timed in their oscillatory motions so as to cancel normally encountered reactionary forces, provision of a gear reduction mechanism beteen the motor and a break-up motion assembly so as to provide break-up motion on a reduced-speed basis, and provision of a pressure-operated lap table for holding the tool on the lap table surface under the influence of air pressure.
Patent TR-199901605-T2 (TR)
Inventor: CONOCHIE DAVID STEWART
IPC: F28F3/12
Filed: 1998-01-07
Abstract: Kömür gibi düsük isil iletkenlige sahip kati malzemelerin iyilestirilmesi yönelik bir islem ve tapkime kabi anlatilmistir. Tepkime kabi, kati malzeme tikiz yataginin isenebilmesi için  içinde bulunduruldugu bir içsel hacim olusturan bir dis zarfa (10) sahiptir ve isil iletken malzemeden yapilmis levhalarin (12a-12h) çogunlugu bu içsel hacimin içine yerlestirilmistir. Her bir levha içinden isi transfer akiskaninin akabilecegi bir ya da birden fazla geçite sahiptir. Kullanimda, her levha, levha alanindaki kati malzemelerle  isi transfer akiskani arasinda bir ya da birden fazla iletken bypas olusturur öyle ki, levhalar üzerinden , kati malzemelerle isi transfer akiskani arasinda yapilan isi alisverisi vasitasiyla katilarin hemen  hemen hepsi istenilen sicaklik araliginda isitilabilsin ya da sogutulabilsinler.
Patent TR-199901834-T2 (TR)
Inventor: BRATZ MATTHIAS
IPC: A01N25/10
Filed: 1998-01-29
Abstract: a) sülfonil üreler grubundan bir etki maddesine ve b) bir alkilpoliglukosid içeren kati karisimlar.
Patent TR-199901855-T2 (TR)
Inventor: SCHWEDE WOLFGANG
IPC: C07J43/00
Filed: 1998-02-09
Abstract: Bulus genel formül I'in yeni 17alfa-flor alkil steroyidleriyle ilgili olup burada R1 bir metil veya etil grubu, R2 n'in 2,3,4,5 veya 6, m>1 ve m+o=2n+1 oldugu CnFmHo formülünün bir artigi R3 serbest,eterize veya esterize edilmis bir hidroksi grubu, R4 ve R5'ten her biri ayri ayri bir hidrojen atomu, beraber ek bir bilesim veya metilen grubu St kismi formül A, B veya C'nin sterodiyal bir ABC-halka sistemi yerine geçer, burada R6 bir hidrojen atomu, düz zincirli bir C1-C4-veya dalli bir C3-C4-alkil grubu veya bir halojen atomu, R7 bir hidrojen atomu, düz zincirli bir C1-C4-veya dalli bir C3-C4-alkil grubu veya St sterodiyal bir ABC-halka sisteminin A'si veya B'si yerine geçtiginde ayrica R6 ve R7 beraberce ek bir bilesim, X bir oksijen atomu, bir hidroksi imino gruplasmasi =N-OH veya iki hidrojen atomu, R8 bir Y resti veya icabinda çok defa bir Y grubu ile yer degistirmis bir aril resti, Y bir hidrojen atomu, bir halojen atomu, bir -OH,-NO2,-N3,-CN,NR9aR9b, -NHSO2R9, -CO2R9,( DEVAMI VAR)
Patent DE-60005191-T2 (DE)
Inventor: JAUNAULT PHILIPPE
IPC: A41D13/04
Filed: 2000-06-21
Granted: 2004-04-08
Abstract: A fastening system includes (3) a flexible plastic neck-enclosing part (7), and a strap (13) arranged in a triangle between the sides of the apron and the rear part of the neck-enclosing part (7) to form both the belt (14) and the braces (15). The belt (14) includes a fast fixing attachment (16) such as a snap fastener and a length-adjusting system with a clip (17) provided on the strap (13) length, particularly on one of the braces (15). The belt-brace system enables to adjust with precision the position of the apron and particularly to distribute suitably the weight on the user's shoulders.
Patent DE-60008903-T2 (DE)
Inventor: SUSSMAN GLENN
IPC: A61B18/04
Filed: 2000-09-18
Granted: 2005-03-03
Abstract: A surgical handpiece having two coaxial tubes or channels mounted within a body. The first tube is used for aspiration and is smaller in diameter than the second tube so as to create an annular passage between the first and second tube. The annular passage communicates with a pumping chamber formed between two electrodes. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the annular passage. The distal end of the annular gap is sealed by sealing together the distal ends of the first and second tube and a plurality or orifices or ports may be formed near the seal. As the expanding gas is propelled down the annular gap, the gas/liquid stream is forced out of the distal orifices in a controlled and directed manner.
Patent DE-60008904-T2 (DE)
Inventor: SUSSMAN GLENN
IPC: A61B18/04
Filed: 2000-09-18
Granted: 2005-03-03
Abstract: A surgical handpiece having two coaxial tubes or channels mounted within a body. The first tube is used for aspiration and is smaller in diameter than the second tube so as to great an annular passage between the first and second tube. The annular passage communicates with a pumping chamber formed between two electrodes. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the annular passage. The electrodes are insulated from each other.
Patent DE-60010455-T2 (DE)
Inventor: MARTINEZ GARCIA EMILIO
IPC: A61D19/02
Filed: 2000-11-03
Granted: 2005-05-12
Abstract: It comprises a tube or catheter (1) that is introduced into the animal's vagina up to the cervix duct (19); characterized in that it additionally comprises a flexible probe (6) constituted of a first flexible tubular body (12), and the outside of which is covered by a layer of a flexible material; all to allow that the probe, after reaching the distal end of the tube (1), may progress through the cervix duct (19) and thereafter through the cervix horn (22). This structure allows to introduce a fluid with spermatozoids, embryos or therapeutic solutions to the anterior third of the uterus horn, or to obtain embryos from the anterior portions of the uterus horn, and all this without sedation or anesthesia and without disturbing the animal's well-being. To facilitate obtaining embryos, the probe includes an elastic small external coating (28) that is inflated through a flexible tube (27) for adapting itself to the uterus horn (22) preventing refluxes when carrying out absorption. It is essentially applied to porcine livestock, small ruminants and any other animal species. <IMAGE>
Patent DE-60011089-T2 (DE)
Inventor: VAUGHN H
IPC: C01B32/336
Filed: 2000-07-07
Granted: 2004-11-18
Abstract: A process is provided for the production of a catalytically active carbonaceous char. By this process, a nitrogen-containing compound is combined with an uncarbonized nitrogen-poor carbon-containing material. The resulting mixture is then carbonized and oxidized at temperatures less than 500° C. The resulting char is next heated to temperatures greater than 500° C and subsequently activated with H2O, CO2, or O2, singly or in any combination, to result in the catalytically active carbonaceous char. The resulting catalytically active carbonaceous char has utility for the chemical conversion of peroxides, hydrides, SOX, NOX, and chloramines in liquid and/or gaseous media.
Patent DE-60015158-T2 (DE)
Inventor: TAKALA HEIKKI
IPC: B01F23/30
Filed: 2000-08-10
Granted: 2005-02-17
Abstract: Leaching of solid matter from a sludge uses a tubular reactor which is equipped with a concentric central pipe and a double-action mixer. The mixer is located in the vicinity of the central pipe's lower edge. Leaching solid matter from a sludge with the aid of an oxygen-containing gas uses a tubular reactor. The reactor is equipped with a concentric central pipe (2), and a double-action mixer (5) in the vicinity of central pipe's lower edge (7). With the aid of the mixer, the sludge flows downward in the central pipe, and then turns upward outside the central pipe as the gas is fed at the same time into the sludge and dispersed into small bubbles. The mixer preferably has nearly rectangular straight lower blades which facilitate the dispersion of the gas and the turning of the discharge sludge into the upward flow. It has curved upper blades which facilitate the downward flow of the sludge in the central pipe. It is preferred that the cross-section area remaining between the mixer and the central pipe is adjusted to be less than half (preferably at most one third) of the flow cross-section area in the central pipe and the lower edge of the central pipe is at a height (measured form the reactor bottom) of 0.7-1.3 times that of the reactor diameter, preferably the same as the diameter. The cross-section ratio of the central pipe and its surrounding reactor casing is preferably below 0.1.
Patent DE-60015888-T2 (DE)
Inventor: BARCHENA JUAN CARLOS
IPC: B29B17/00
Filed: 2000-09-20
Granted: 2005-12-01
Abstract: A product obtained by recycling domiciliary sweepings, for the manufacture of all type of mouldable products. The product comprises a first component containing plastic polyethylene and polypropylene materials in a proportion that ranges between 25% and 30% of the final weight of the product; a second component of plastic PET type materials ranges between 30% and 40% of the total weight of the product; and a third component selected from: PVC, styrene, polyamides, polycarbonates, polystyrene, ABS, aluminum and cardboard.   A procedure for obtaining the product, includes separating from sweepings materials plastics materials found without classifying nor washing them; crushing this material in a mill (5); simultaneously warming up to a temperature of up to 300 DEG C and extruding said material through an extruder (8) into a mould (9); and submerging the mould (9) in a water tray (10). <IMAGE>
Patent DE-60025690-T2 (DE)
Inventor: HAUCHECORNE JACQUES
IPC: B65D77/20
Filed: 2000-11-22
Granted: 2006-08-31
Abstract: The packaging sachet (10) for foods stuffs has a first layer and a heat weldable layer between which is a layer of permanent adhesive. The sheet defines a seating (20) with a passage (18) initially closed by a heat weld (16) between the sheet and a complementary support behind the weldable layer . The weld line forms a stress concentration when the sachet is subjected to opening forces. The heat weld can form pointed failure lines along its edges.