Patent AU-2013200903-B2 (AU)
Title: CDIM binding proteins and uses thereof
Inventor: TENG NELSON N H
IPC: A61K38/00
Filed: 2013-02-08
Granted: 2015-05-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/120012 A2 15 August 2013 (15.08.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K16/28 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US2013/025430 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 8 February 2013 (08.02.2013) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/633,330 8 February 2012 (08.02.2012) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: IGM BIOSCIENCES INC. [US/US]; 2401 kind of regional protection available): ARIPO (BW, GH, Mission College Blvd.. #210, Santa Clara, CA 95054 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (72) Inventors; and UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants : TENG, Nelson, N.H. [US/US]; 24 Bluebell TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Lane, Hillsborough, CA 94010 (US). BHAT, Neelirna, M. EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, [US/US]; 90 Alma Court, Los Altos, CA 94022 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, BIEBER, Marcia, M. [US/US]; 740 Orange Avenue, Los TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Altos, CA 94022 (US). KEYT, Bruce, A. [US/US]; 1180 ML, MR, NE, SN, TD, TG). Lakeview Drive, Hillsborough, CA 94010 (US). Declarations under Rule 4.17: (74) Agent: MILLAUER, Birgit; Chao Hadidi Stark & Barker, - of inventorship (Rule 4.17(iv)) LLP, 770 Menlo Ave. Suite 205, Menlo Park, CA 94025 (US). [Continued on next page] (54) Title: CDIM BINDING PROTEINS AND USES THEREOF (57) Abstract: The present disclosure relates to Cell Death FIGURE 7 Inducing Molecule ("CDIM") binding proteins and phar Complement Dependent Cytotoxicity: maceutical compositions thereof. Particularly, the disclos Samples of IgM on CDIM Expressing Cells (NaIm-6) ure provides CDIM binding proteins that are useful in the selective depleting and killing of B cells, including neo plastic B cells as well as neoplastic cells that are not of B 100cell origin that express CDIM-like antigens. In addition, 10 * hm216 the disclosure encompasses polynucleotides encoding the disclosed antigen binding proteins, and expression systems 8 GM23 for producing the same. Further the present disclosure en compasses methods of treating patients with B cell prolif IG M35 erative and mediated diseases by administering the CDIM 6G M39 binding proteins as well as diagnostic assays for identifyG 3 ing proteins that bind to CDIM. The disclosure further contemplates diagnostic assays for identifying patient pop ulations that can be treated with the CDIM binding pro teins. ga 0-.4 1gM concentration (Kg/mI) W O 2 0 13 /12 0 0 12 A 2 ||lll ll|||ll|||lllllllllll|III|||||||||||||||V|||||||||||||||||||||||||||||||||||||| Published: - with sequence listing part of description (Rule 5.2(a)) without international search report and to be republished upon receipt of that report (Rule 48.2(g))