baber/WOPTO huggingface dataset:
Patent PT-906430-E (PT)
Title: Biosynthesis method enabling the preparation of o-phospho-l-threonine
Inventor: BLANCHE FRANCIS
IPC: C12P19/42
Filed: 1997-05-05
Abstract: In the biosynthesis of cobalamines (A) by fermenting an appropriate prokaryotic microorganism, the new feature is: (a) the microorganism is transformed with \- 1 DNA fragment encoding an enzyme involved in biosynthesis of O-phospho-L-threonine (I); (b) (I) is added to the culture medium or (c) aerobic producing organisms are transformed with \- 1 DNA fragment encoding an enzyme involved in biosynthesis of 5,6-dimethylbenzimidazole (II). Also claimed are microorganisms of (a) and (c).
Patent PT-931083-E (PT)
Inventor: COREY ELIAS J
IPC: C07D317/64
Filed: 1997-09-17
Abstract: The present invention is directed to a synthetic process for the formation of ecteinascidin compounds and related structures, such as the saframycins. In one particularly preferred embodiment, the present invention provides a synthetic route for the formation of ecteinascidin 743 (1),   <IMAGE>   an exceedingly potent and rare marine-derived antitumor agent which is slated for clinical trials. The process of this invention is enantio- and stereocontrolled, convergent and short. Also disclosed are novel process intermediates, useful not only in the total synthesis of ecteinascidin 743, but also other known ecteinascidin compounds, including derivatives and analogs thereof.
Patent PT-884532-E (PT)
Inventor: PONTIGGIA PHILIPPE
IPC: F24H9/20
Filed: 1998-04-16
Abstract: The temperature regulation takes measurements (11,12) of water temperature at the inlet and at the outlet of the area (3) of pipe exposed to the flame (7). The temperature measurements are delivered to a controller (10). The burner has its fuel supply controlled by a valve (5) which can adjust the fuel flow and can cut off the fuel supply to the burner. The valve is controlled by a solenoid (9), which is in turn controlled by the controller that receives the temperature data. The controller can cause the burner to operate with continuous control or in chopped mode, which is invoked at low power levels where flame would be unstable.
Patent PT-1100542-E (PT)
Inventor: DAVID WILLIAMS L
IPC: A61K47/48
Filed: 1999-08-02
Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Patent SG-9591-G (SG)
Title: Coloured hydrogel objects and their production
IPC: C08J7/00
Filed: 1991-02-19
Abstract: Shaped organic polymer hydrogels, especially contact lenses, are provided with opaque or translucent colouring so as to be capable of masking effectively any underlying colour, e.g. the natural colour of the eye. The hydrogel may be rendered opaque by precipitation in situ of a white or yellow water-insoluble, inorganic or organic material e.g. barium sulphate or an optical brightener and then coloured with a suitable dyestuff.
Patent IE-780023-L (IE)
Title: Potato harvester
IPC: A01D27/04
Filed: 1978-01-05
Abstract: This machine comprises a ploughshare, a conveyor to upwardly inclined ribbed belt and feeding a table or a sorting belt, a lifting unit forming a path for gripping and transporting plants Potato above the conveyor and a device for facilitating the engagement of the on this journey Fanes. 
[FR2377143A1]
Patent IE-780077-L (IE)
Title: 11-beta-substituted steroids
IPC: C07J33/00
Filed: 1978-01-13
Abstract: Novel 11 beta -substituted- DELTA 9-ene-5 alpha -ols of the formula <IMAGE> I wherein K is a blocked ketone in the form of a ketal, thio-ketal or methyloxime, X is a pentagonal or hexagonal ring optionally substituted, R1 is selected from the group consisting of branched and straight chain alkyl of 1 to 12 carbon atoms, unsaturated alkyl of 2 to 8 carbon atoms optionally substituted, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and heterocycle with at least one hetero oxygen or sulfur atom and R2 is alkyl of 1 to 4 carbon atoms which are useful intermediates and a process for their preparation.
[US4147695A]
Patent IE-860385-L (IE)
Title: Peptides containing an aliphatic-aromatic ketone side chain
IPC: C07K14/575
Filed: 1986-02-11
Abstract: GnRH peptide analogs which regulate the secretion of gonadotropins by the pituitary gland and either promote or inhibit the release of steroids by the gonads. Administration of an effective amount of a GnRH antagonist prevents ovulation of female mammalian eggs and/or the release of gonadotropins. Administration of GnRH agonists can be used to regulate fertility in male and female mammals.These and other peptide hormones exhibit improved binding efficiency and biological potency as a result having a residue in a critical, generally central location in the chain which residue contains a mixed alkyl ketone side-chain terminating in an aromatic group. Methods for efficiently synthesizing these peptides from readily available compounds are disclosed.
Patent IE-34126-L (IE)
Title: Perforating food casings.
IPC: B65B61/02
Filed: 1970-04-30
Abstract: Perforated tubular food casings having substantially free-draining vent holes are obtained by passing a flattened web of tubular food casing between contiguous, counter-rotating punch and support rolls. Positioned on the circumference of one roll are a plurality of radially mounted, flat-faced, sharp-edged punches adapted to cut through the casing and indent a resilient support surface on the other roll.
[US3779285A]
Patent IE-39111-L (IE)
Title: Concrete products.
IPC: B28B7/46
Filed: 1974-04-01
Abstract: 1466663 Wetting concrete G MATTHEWS RESEARCH & DEVELOPMENT CO Ltd 2 April 1974 [18 April 1973] 18737/73 Heading B5A Dry particulate material (e.g. cement with granite, or quick setting plaster of Paris with exfoliated mica) is placed in a mould, and a vacuum applied to a first portion of the surface of the material to cause compaction. Liquid (e.g. water) is applied to a second part of the surface for drawing in by the vacuum. Further compaction does not occur after the liquid has been applied to the surface. As described for moulding concrete articles, a wetted filter paper is placed in each of an endless procession of pivotally interconnected moulds 20 (Fig. 3), to the base of each of which a vacuum is supplied by a pair of pipes 28. A hopper 48 containing a dry white cement, granite and colour pigment moves along with, and above, a first mould, moves down into the mould, and distributes the coloured cement &c. on the filter paper. The hopper 48 then rises and moves back to an initial position due to a counterweight 49, to repeat the feeding with successive moulds. As the moulds pass beneath a hopper 33, coloured or uncoloured dry cement and granite are sprinkled to fill the moulds, and the cement is levelled by a roller 60, while compacted by the applied vacuum. Water is sprayed from a pipe 64 (or flooded on from a filter cloth endless belt) and sucked into the cements, and excess removed, by the vacuum. As each mould base contacts a fixed rail, the vacuum is released from the contacting mould and replaced by a positive pressure that discharges the concrete article on to a pallet and carrier 66 (Fig. 7). The filter paper protects the concrete surface. The carrier moves along an inclined rail 68 to deposit the pallet on intermittently moving endless chains 70 (Fig. 3 also), and returns upwards with a fresh pallet to receive the next discharged article. One or both major surfaces of an article are textured or given an exposed aggregate finish. Moulds and vacuum.-Each mould 20 is open-topped and over its base receives in succession a wire or plastics mesh (or the base is channelled to define a grid), an apertured plate, the filter paper and a second apertured plate acting as a template to give an embossed surface to the concrete. The vacuum is applied to the bases of two moulds by pipes wound in opposition on a drum, and is fed to the remaining mould bases by interconnecting pipes. One of the drum wound pipes includes a concentric pipe leading to a positive pressure source. Hoppers.-The hopper 48 includes a wire mesh base and pattern plate through which material is fed by reciprocated scraper blades (51) (see Fig. 10, not reproduced). Hopper 33 includes an upstream outlet that sprinkles cement through a scalloped plate, to prevent disturbance of the coloured cement, and a downstream outlet that applies cement in bulk to fill the moulds.
[GB1466663A]
Patent IE-880901-L (IE)
Title: A crivastine containing composition
IPC: A61K9/52
Filed: 1988-03-25
Abstract: The invention relates to a controlled release pharmaceutical formulation for oral administration which comprises discrete units comprising acrivastine or a salt thereof coated with a mixture containing:   a) a copolymer or polymer containing repeating monomer units selected from alkyl esters of acrylic and methacrylic acids and   b) ethyl cellulose, and a process for preparing such formulations.
Patent IE-32249-L (IE)
Title: RESOLUTION OF DL-6-PHENYL-2, 3, 5, 6-TETRA-HYDROIMIDAZO [2,¹1-b] THIAZOLE
IPC: C07D513/04
Filed: 1968-08-08
Abstract: 1,169,310. Optical isomers of condensed imidazo - thiazole derivative. IMPERIAL CHEMICAL INDUSTRIES OF AUSTRALIA & NEW ZEALAND Ltd. 2 Aug., 1968 [24 Aug., 1967; 11 Jan., 1968; 18 Jan., 1968], No. 37039/68. Heading C2C. Optically active D- and L-isomers (the L- isomer being particularly suitable for the treatment of helminthiasis) of 6-phenyl-2,3,5,6-tetrahydroimidazo - (2,1-b) thiazole (tetramisole for short) are separated from their racemate by a process which comprises adding to a predominantly aqueous solution of said racemate, or a water-soluble derivative thereof, an optically active isomer of a carboxylic acid or a water-soluble derivative thereof, which acid has a molecular weight greater than 250, forms a salt with one of said tetramisole isomers having a solubility in said aqueous medium considerably lower than that of the corresponding salt of the other tetramisole isomer and wherein the concentration of said racemate in solution is such that said less soluble tetramisole isomer salt crystallizes from said aqueous medium to the substantial exclusion of the other tetramisole isomer salt. A preferred resolving agent is a water-soluble derivative of an optically active isomer of an amino acid, e.g. an N-arylsulphonyl- L(+)- or -D(-)-glutamic acid and the novel L(-)- and D(+)-tetramisole V-arylsulphonyl- L( + )- and D(-)-glutamate salts (the term aryl includes: phenyl-, p-toluene-, p-fluorobenzene-, p-bromobenzene- and p-nitrobenzene-) including the hydrates thereof are described.
[GB1169310A]
Patent FI-831193-L (FI)
Inventor: ACKER ROLF-DIETER
IPC: A01N55/00
Filed: 1983-04-08
Abstract: Organosilyl compounds of the general formula I    <IMAGE>  (I)  where R1, R2 and R3 are alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or substituted aryl, R4 and R5 are alkyl or hydrogen and Y is CH2, oxygen, nitrogen or alkyl-substituted nitrogen, their salts and fungicides containing these compounds.
Patent IE-41368-L (IE)
Title: Sulphoglycopeptides from milk as therapeutic agents
IPC: A61K38/00
Filed: 1975-05-28
Abstract: 1448660 Sulphoglycopeptides CRINOS INDUSTRIA FARMACOBIOLOGICA SpA 23 May 1975 [30 May 1974] 22932/75 Heading C3H Starting from amixture of a glycopeptide extracted from milk or casein, (b) an aprotic, non-aromatic, water-miscible solvent (c) a tertiary base having a boiling point of from 100-250‹ C. and (d) a sulphonating agent selected from sulphuric acid, oleum, chlorosulphonic acid and an adduct of sulphur tinoxide and an organic compound, sulphoglycopeptides are made by maintaining an initial temperature at contact between the glycopeptide and the sulphonating agent of from about - 20‹ to 20‹ C., raising the temperature to a range of from about 60‹ C. to about 90‹ C. and recovering the resulting sulphoglycopeptide. If desired the resulting sulphoglycopeptide may be further reacted with an alkali metal or alkaline earth metal hydroxide or ammonium hydroxide to convert the sulphoglycopeptide to its corresponding salt which may thereafter be precipiaated by addition of acetone on methanol. Such salts may be ionexchanged with Zn<SP>++</SP>, Ca<SP>++</SP>, Ba<SP>++</SP>, Sr<SP>++</SP>, Cu<SP>++</SP>, Ni<SP>++</SP>, Co<SP>++</SP>, Mg<SP>++</SP>, Bi<SP>++</SP>, Au<SP>+</SP> or Al<SP>+++</SP> by passage through a cation exchange resin.
[GB1448660A]
Patent IE-39709-L (IE)
Title: Apparatus for subjecting materials to high pressure.
IPC: B30B11/00
Filed: 1974-06-12
Abstract: 1477454 High pressure apparatus NATIONAL RESEARCH DEVELOPMENT CORP 12 June 1974 [12 June 1973] 11797/73 Heading B1X Apparatus to subject materials to high pressure, comprises pressure sources mounted to converge upon a space, and a plurality of similar and moveable anvils, 31-36, arrangeable in a cluster within this space and in which the cluster completely defines an enclosed parallelepipedal volume to be filled with the material to be compressed, each anvil has side faces and opposed end faces, part of a first of the opposed end faces of each anvil defines a face of the enclosed volume, the second and opposite face of each anvil is exposed, whereby it may be acted upon by one of the pressure sources, a plurality of the side faces of each anvil are in sliding contact with faces of adjacent anvils in the cluster, whereby the anvils by mutual sliding movement may converge upon the enclosed volume and reduce it by the same proportion in each of its linear dimensions and the second end face of each anvil lies out-of-parallel with the first end face, and out of perpendicular with the side faces, whereby the face of the pressure source against the second end face of that anvil may be resolved into components urging that anvil into contact with adjacent anvils. The first end face and the sliding faces of each anvil may be plane faces lying mutually at right-angles to each other, and the second end face is a plane face lying out of parallel to all the other faces. The apparatus is for the production of artificial diamonds.
[GB1477454A]
Patent IE-38073-L (IE)
Title: Colouring of edible and cosmetic compositions
IPC: A23L1/275
Filed: 1973-08-10
Abstract: An orange colouring material which is 1-(azo-benzene-4-sulphonic acid) -2-naphthol-6 8-disulphonic acid named "Orange AB" is effective as a colouring agent for foodstuffs and cosmetic compositions.
[US3939283A]
Patent IE-901469-L (IE)
Title: Pharmaceutical compositions
IPC: A61P1/00
Filed: 1990-04-25
Abstract: Pharmaceutical compositions suitable for intra-rectal administration in the form of a foam are described which comprise a therapeutically effective amount of 5-aminosalicylic acid, a pharmaceutically acceptable aqueous carrier therefor, and means for generating a foam. Methods for their preparation and their use in the treatment of ulcerative colitis are also described.
Patent IE-35429-L (IE)
Title: Winding yarn
IPC: B65H54/42
Filed: 1970-12-30
Abstract: Method and apparatus for tandem yarn winding filamentary structures, such as filaments or yarn, onto a plurality of bobbins in such a manner so as to substantially preclude the migration of finish from one filamentary structure to the other. A traversing guide conducts each pair of yarn onto the surface of the drive roll. The yarns pass around at least a portion of the surface of the drive roll before being wound on the bobbins which are driven by the drive roll. Each bobbin is mounted on a chuck which is movable on a carriage, preferably along a straight path toward and away from the drive roll. As the yarn package builds, the axis of rotation of each bobbin progressively moves away from the drive roll. A cam and follower associated with the carriage imposes a predetermined resistance to movement of the carriage, thereby maintaining a suitably programmed force between the bobbin and the drive roll throughout the winding process, which force is necessary to build stable and well-formed yarn packages.
[US3642217A]
Patent IE-811820-L (IE)
Title: Cloche
IPC: E04H15/64
Filed: 1981-08-10
Abstract: A cloche frame comprises a substantially U-shaped support (1) and a securing means (3), the support having an outwardly facing channel (2) running substantially along the length of the outer surface and the securing means being adapted to be engaged withing the channel in order to secure a covering in the channel. 
[EP0046260A1]
Patent IE-892126-L (IE)
Title: Wound dressing system
IPC: A61F13/02
Filed: 1989-06-30
Abstract: A novel two-piece wound dressing, providing protection during dressing changes to the delicate healing skin directly surrounding the wound, is provided according to the present invention. The dressing comprises a baseplate (18) having an adhesive surface for contacting surrounding skin, and has an aperture (16) extending completely through it over which a wound pad (24) of a desired wound dressing material can be placed. Means are also provided for attaching the wound pad to the baseplate.
Patent IE-44845-L (IE)
Title: Pyrimidone and thiopyrimidone derivatives
IPC: A61K31/505
Filed: 1976-09-29
Abstract: There is disclosed the preparation of compounds of the formula wherein Het' is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen (preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridyl ring optionally substituted by lower alkyl {preferably methyl), lower alkoxy (preferably methoxy), halogen (preferably chlorine or bromine), amino or hydroxy, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3-(1,2,5) thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2-(5-amino-1,3,4-thiadiazolyl) ring; Z is sulphur or a methylene group; X is oxygen or sulphur; W is methylene, oxygen or sulphur; m and n are such that their sum is from 1 to 4 when W is oxygen or sulphur, or from O to 4 when W is methylene; A is a 1- or 2-naphthyl ring, a 2,3-dihydro-1,4-benzodioxinyl or a 1,3-benzodioxolyl ring, a phenyl ring substituted with one or more lower alkyl, lower alkoxy, halogen, arylalkoxy, hydroxy, alkoxyalkoxy, trifluoromethyl, di(loweralkyl)amino, phenoxy, halophenoxy, alkoxyphenoxy, phenyl, halophenyl or alkoxyphenyl group and when is not a methylene group, A may also be phenyl; and Y3 is hydrogen or lower alkyl. The compounds have both histamine H1-antagonist and H2-antagonist activity.
[CA1067076A]
Patent IE-45982-L (IE)
Title: MONOCYCLIC ß-LACTAMS WITH ANTIBACTERIAL ACTIVITY.
IPC: A61P31/04
Filed: 1977-11-09
Abstract: A monocyclic beta -lactam containing a cis- beta -acylamino moiety as in the penicillin and cephalosporin antibacterials is disclosed. These compounds have antibacterial activity against a variety of Gram-positive and Gram-negative organisms. Intermediates useful for the preparation of these antibacterials are also disclosed.
[US4144333A]
Patent IE-42455-L (IE)
Title: Alkylated derivatives of antibiotic bm 123
IPC: C07H15/26
Filed: 1975-12-05
Abstract: Reductive alkylation with aldehydes R1-CHO or ketones R2-CO-R3 results in alkylation of the antibiotics BM 123 gamma 1, gamma 2 or mixtures thereof at the terminal primary amino group. With ketones there is single N-alkylation, while with aldehydes the primary amino group is substituted once or twice, depending on the amount of reagents, and the proximal secondary amino group on the side chain can likewise be alkylated. The meanings of R1, R2 and R3 are to be found in Claim 1. The resulting derivatives have a potent antibacterial action; they can be used for the treatment of infectious diseases.
[GB1536153A]
Patent IE-892837-L (IE)
Title: Continuous sonication method for preparing protein¹encapsulated microbubbles
IPC: A61K9/50
Filed: 1989-09-04
Abstract: An ultrasonic imaging agent is produced by a continuous sonication processing of an aqueous solution of heat-denaturable biocompatible protein. The solution is carefully preheated to a temperature of incipient protein denaturation without forming insolubilized protein. A gaseous fluid, preferably air, is added to the solution. In the sonication, the air-containing solution is foamed, increasing the formation and concentration of microbubbles, and the solution is further heated to insolubilize a portion of the protein, thereby encapsulating the microbubbles and forming particulate microspheres.
Patent NO-752341-L (NO)
Inventor: SAVIGNY A
IPC: H01R4/16
Filed: 1975-06-27
Abstract: Fremgangsmåte for sammenkobling av elektriske ledere og sammenkobling oppnådd ved denne fremgangsmåte.
Patent NO-762271-L (NO)
Inventor: LILJEGREN G
IPC: B28B1/087
Filed: 1976-06-30
Abstract: Fremgangsmåte for støping av en støttefot i betong, beregnet for pilarelement.
Patent NO-831442-L (NO)
Inventor: DEHLEN BENGT LARS ARNE
IPC: B07B1/48
Filed: 1983-04-25
Abstract: The screening system comprises a screen frame (7) with supporting elements (9) for a screen deck (1) fastened in the frame. The screen deck comprises several elongated screen elements placed adjacent each other. Included in the screen elements are stiffening elements. The stiffening elements are prestressed against the supporting elements by elastic deformation upon mounting in the frame. They can be plastically deformed in a direction opposite to this elastic deformation. The spring-back force resultant of the elastic deformation can be at least as large as an inertia resultant acting on the screen deck in the opposite direction, when the screen deck is used in a dynamic screening machine.
Patent NO-843237-L (NO)
Inventor: MUELLER KARL-FRIEDRICH
IPC: A61K47/00
Filed: 1984-08-14
Abstract: A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
Patent NO-851883-L (NO)
Inventor: HANNUKAINEN HANNU
IPC: G01L/
Filed: 1985-05-10
Abstract: A tubular flexural bar (15), consisting of magnetic material, contains an iron core (23) of magnetically soft material, on opposing limbs of which are wound a pair of exciting coils (27,28). The shaped corners of the iron core (23) make good magnetic contact with the inner surface of the flexural bar (15). Magnetic flux is induced by the coil excitation in three parts, the first two producing flux which passes through two paths in the flexural bar, whilst a third flux circulates around the core and through the air gap (25) to be detected by a Hall element (26). When the flexual bar (15) is loaded, its reluctance changes and the first fluxes become unequal, changing the gap flux with a resulting signal from the element (26) being related to the distorting force applied to the flexural bar (15).