baber/WOPTO huggingface dataset:
Patent CA-3057292-A1 (CA)
Title: Modified oligonucleotides and therapeutic uses thereof
Inventor: ROLOFF ALEXANDER
IPC: A61P35/00
Filed: 2018-03-21
Abstract: The present disclosure generally provides nucleotide-based compounds useful for treating various diseases, including cancer. In some aspects, the disclosure provides oligonucleotides that are chemically modified to include an engineered fatty-acid residue, for example, to assist with improving the half-life of such compounds or assisting with cell penetration (e.g., penetration into tumor cells). In some aspects, the disclosure provides compositions that include such modified nucleotides and a protein, such as albumin or mimetics thereof. The disclosure provides various uses of the compounds and compositions.
Patent CA-3058015-A1 (CA)
Title: Detection reagent, detection kit and detection method for itga4 gene methylation
Inventor: LIU XIANGLIN
IPC: C12Q1/68
Filed: 2017-12-26
Abstract: Provided are a detection kit and detection method for ITGA4 gene methylation. A primer and a probe provided by the present invention are matched, then detection can be carried out by taking a feces sample as an object, and thus the detection is simple, convenient and rapid. The detection can also be carried out on tissue specimens. Moreover, in the process of detecting the samples, the detection specificity and sensitivity are also improved. The experiment proves that for the feces specimen, when the specificity is 95.2%, the sensitivities of the methylated ITGA4 to intestinal cancer and adenoid tumor are 83.8% and 41.6%, respectively; and for the intestinal cancer tissue, when the specificity is 97.6% (40/41), the detection rates for colorectal cancer and adenoid tumor are 96.2% (101/105) and 71.6% (78/109), respectively. The effects are superior to the detection effects obtained by adopting other primers or probes.
Patent CA-3058831-A1 (CA)
Inventor: BELAND STEPHANE
IPC: F16B2/02
Filed: 2019-10-17
Abstract: A device for mounting a light fixture structure to a ceiling grid. The device includes an anchor structure extending from the light fixture structure, with a pair of arm structures spaced to receive a ceiling grid segment therebetween at an anchor location on the ceiling grid adjacent a lower region of the ceiling grid. The arm structures have respective distal regions configured to be accessible from an upper region of the ceiling grid and a clamp structure configured to traverse laterally relative to the distal regions to couple with the respective distal end regions and thereafter to be transferable between a released position and a locked position. When in the locked position, the ceiling grid segment held between the anchor and clamp structures place the light fixture structure in the mounted position.
Patent CA-3060762-A1 (CA)
Title: Diagnosis assisting device, and image processing method in diagnosis assisting device
Inventor: MATSUNAGA KAZUHISA
IPC: G06N3/08
Filed: 2017-07-31
Abstract: Provided are a diagnosis assisting device that facilitates a user to grasp a difference of an affected area to perform a highly precise diagnosis assistance, an image processing method in the diagnosis assisting device, and a program. An image processing method in a diagnosis assisting device that diagnoses lesions from a picked-up image comprises performing an image correction on the picked-up image for diagnosis, and subtracting a target pixel value from a pixel value of the picked-up image having undergone the image correction to obtain an input image to an identifier that identifies diseases based on the unknown picked-up image relating to an object to be diagnosed.
Patent CA-3062631-A1 (CA)
Title: Fe-si base alloy and method of making same
Inventor: CHINNASAMY CHINS
IPC: C22C38/02
Filed: 2018-05-17
Abstract: A soft magnetic alloy having a good combination of formability and magnetic properties is disclosed. The alloy has the formula Fe100-a-b-c-d-e-fSia MbLcM'dM"eRf wherein M is Cr and/or Mo; L is Co and/or Ni; M' is one or more of Al, Mn, Cu, Ge, Ga; M" is one or more of Ti, V, Hf, Nb, W; and R is one or more of B, Zr, Mg, P, Ce. The elements Si, M, L, M', M", and R have the following ranges in weight percent: Si 4-7 M 0.1-7 L 0.1-10 M' up to 7 M" up to 7 R up to 1 The balance of the alloy is iron and usual impurities. A thin-gauge article made from the alloy and a method of making the thin-gauge article are also disclosed.
Patent CA-3062840-A1 (CA)
Title: Battery with acidified cathode and lithium anode
Inventor: JOHNSON PAIGE L
IPC: H01M4/48
Filed: 2018-05-16
Abstract: A battery comprising an acidified metal oxide ("AMO") material, preferably in monodisperse nanoparticulate form 20 nm or less in size, having a pH < 7 when suspended in a 5 wt% aqueous solution and a Hammett function H0 > - 12, at least on its surface.
Patent CA-3063953-A1 (CA)
Title: Derivatives of resiquimod
Inventor: YANG LIHU
IPC: A61P35/00
Filed: 2018-05-18
Abstract: A deuterated compound having structural formula I or a pharmaceutically acceptable salt thereof: Values and example values of the variable in formula (I) are disclosed herein. Also disclosed are the use of compounds of formula (I) in the methods of treating a disease selected from cancer, an autoimmune disease, and an infectious disease, and methods of enhancing an immune response to an antigen.
Patent CA-3066642-A1 (CA)
Inventor: MILLER MATHEW G
IPC: C12N9/12
Filed: 2018-06-19
Abstract: La présente invention concerne des variants d'ARN polymérase T7 modifiés et des compositions de ceux-ci. Ces variants ont été développés en vue d'une incorporation sélective de l'analogue GTP coiffé symétrique sur GTP au début de la transcription in vitro. La présente invention concerne également des procédés d'utilisation des variants décrits ici. La présente invention concerne en outre l'utilisation des compositions décrites ici.
Patent CA-3066713-A1 (CA)
Title: Compositions and methods for enhancing cancer chemotherapy
Inventor: HSIA HOUN SIMON
IPC: A61P35/00
Filed: 2018-06-13
Abstract: A nutritional supplement that includes fish oil and selenium has been found to provide a variety of activities beneficial in treating cancer and associated conditions. Such a supplement provides synergistic effects in reducing cancer cell proliferation when used in combination with chemotherapeutic drugs, and can reduce proliferation in drug-resistant cancer cells when used in combination with chemotherapeutic drugs to which the cells are resistant. Effects in reducing angiogenesis, reducing metastasis, reducing the number of circulating cancer cells, and modifying AXL signalling were also found. In addition, use of such a supplement was found to reduce wasting associated with cachexia and reduce circulating cytokines associated with inflammation. Overall effects were found to extend survival in clinical studies.
Patent CA-3067512-A1 (CA)
Title: Cannabidiolic acid esters compositions and uses thereof
Inventor: MECHOULAM RAPHAEL
IPC: A61K31/235
Filed: 2018-06-20
Abstract: Cannabidiolic acid esters, compositions comprising them and uses thereof in the treatment of various diseases, conditions and symptoms.
Patent CA-3067697-A1 (CA)
Title: Inorganic non-chrome aqueous treatment composition and process for coating metal surfaces
Inventor: CHURCH RICHARD J
IPC: C23C22/44
Filed: 2018-06-25
Abstract: A chromium-free aqueous treatment solution for coating metal surfaces which meets corrosion resistance, electrical contact resistance, and paint adhesion requirements set forth in MIL-DTL-81706B, Class 3. The treatment solution contains a compound of a Group IV-B element, and a vanadium ion. The solution may be inorganic and molybdate-free.
Patent CA-3068108-A1 (CA)
Inventor: LEBON JACQUY
IPC: B65D55/02
Filed: 2018-06-22
Abstract: L'invention concerne une fermeture à l'épreuve des enfants (10) destinée à un récipient (20) avec une ouverture de filet de vis externe, et comprenant un capuchon externe (12) ayant une première paroi latérale (16) et une première paroi supérieure (18) et un capuchon interne (14) ayant une seconde paroi latérale (42) et une seconde paroi supérieure (44), le capuchon interne (14) étant emboîté de manière coaxiale à l'intérieur du capuchon externe (12) et étant pourvu d'un filetage interne (36) pour visser le capuchon interne (14) sur le récipient (20), le capuchon externe (12) et le capuchon interne (14) étant pourvus de premiers moyens de mise en prise coopérant (62, 66), les premiers moyens de mise en prise (62, 66) étant agencés et formés de telle sorte que, lors de l'ouverture de la fermeture (10), le capuchon interne (14) soit entraîné en rotation par le capuchon externe (12) lors de l'application sur le capuchon externe (12) d'une force axiale plus un couple mécanique rotatif dans une première direction de rotation et des seconds moyens de mise en prise coopérant (60, 68) qui sont agencés entre la première paroi supérieure (18) et la seconde paroi supérieure (44) et formés de telle sorte que lors de la fermeture de la fermeture (10), le capuchon interne (14) soit entraîné en rotation par le capuchon externe (12) lors de l'application d'un couple mécanique rotatif dans une seconde direction de rotation sur le capuchon externe (12), les seconds moyens de mise en prise coopérant comprenant une pluralité d'éléments élastiques de type bande (60), chaque élément élastique de type bande (60) étant incliné par rapport à la première paroi supérieure (18) et comprenant un élément de renforcement (61) disposé entre la première (18) ou la seconde paroi supérieure (44) et l'élément élastique en forme de bande (60) relié à celle-ci.
Patent CA-3069239-A1 (CA)
Title: Cylinder system with relative motion occupying structure
Inventor: HANNA IBRAHIM MOUNIR
IPC: F15B15/20
Filed: 2019-01-17
Abstract: Implementations are disclosed herein that relate to a cylinder occupying structure. An example provides a cylinder system comprising a mechanical cylinder including an internal space in which a fluid is introduced, and a piston configured for reciprocating motion in the internal space, and a cylinder occupying structure including an insertion rod acting as a second piston, wherein the insertion rod is variably inserted into, and retracted from, the internal space of the cylinder in correspondence with the reciprocating motion of the piston and where parts of the insertion rod and the piston may surround the combustion space.
Patent CA-3070152-A1 (CA)
Title: Collapsible gate for a transport trailer
Inventor: WALKER JUSTIN
IPC: B62D21/20
Filed: 2020-01-28
Abstract: A gate assembly comprising of a track comprising a vertical portion and two angular portions on opposing sides of the hopper. A pair of rectangular gates each comprising a longitudinal edge and opposing lateral edges slidingly engaged on the track allows the gates to move between a lowered, closed position and a raised, open position. A hinge combines the longitudinal edge of each of the pair of rectangular gates and allows them to pivot toward and away from each other during closing and opening, respectively.
Patent CA-3070277-A1 (CA)
Inventor: SHIH FRANK YEN-JER
IPC: C09J7/29
Filed: 2018-07-19
Abstract: L'invention concerne un revêtement barrière qui est utilisé en combinaison avec un adhésif durci aux UV sur un papier support pour prolonger la pégosité et les performances globales de l'adhésif. Certains aspects du revêtement incorporent un matériau chélatant pour arrêter ou empêcher complètement la migration d'ions indésirables, comprenant éventuellement les ions calcium, entre le papier support et l'adhésif d'une manière qui nuit à l'adhésif. Le papier est particulièrement bien adapté aux étiquettes et à d'autres utilisations similaires.
Patent CA-3072402-A1 (CA)
Title: Rotor pour eolienne a axe vertical
Inventor: RODWAY GILES HENRY
IPC: F03D3/06
Filed: 2018-07-31
Abstract: L'invention concerne un rotor destiné à une éolienne à axe vertical comprenant : des première et seconde pales (6a, 6b) reliées l'une à l'autre et agencées pour tourner autour d'un axe (10) ; les première et seconde pales (6a, 6b) sont disposées à 180° l'une par rapport à l'autre et sont décalées par rapport à l'axe (10) dans une direction radiale ; un bord interne (14, 14') de chaque pale (6a, 6b) est espacé radialement vers l'intérieur par rapport à un bord externe (12, 12') de la pale opposée (6a, 6b) pour former une paire d'ouvertures diamétralement opposées (26a, 26b) qui s'ouvrent dans des directions opposées ; chacune des première et seconde pales (6a, 6b) comprenant une première section incurvée (20) et une seconde section incurvée de façon opposée (22), les première et seconde sections incurvées (20, 22) étant séparées par un point d'inflexion (24) ; et les première et seconde sections incurvées (20, 22) des première et seconde pales (6a, 6b) se chevauchant mutuellement pour former un passage (28) entre les première et seconde pales (6a, 6b) qui s'étend entre les ouvertures (26a, 26b).
Patent CA-3072633-A1 (CA)
Inventor: SCHNEIDER CHRISTOPHER MICHAEL
IPC: E01C5/00
Filed: 2020-02-14
Abstract: Il est décrit un assemblage de tuiles à terrasse. Lassemblage de tuiles à terrasse comprend un cadre ayant au moins quatre côtés. Lassemblage de tuiles à terrasse comprend également une pluralité de barres pour la fourniture dune structure support au cadre. Lassemblage de tuiles à terrasse comprend des sous-poutres parallèles fixées de manière permanente entre deux côtés opposés du cadre et installées sur la pluralité de barres. Lassemblage de tuiles à terrasse comprend également des appareils de fixation à attaches à engagement par piétinement, chaque appareil de fixation à attaches à engagement par piétinement étant installé sur lune des sous-poutres. Lassemblage de tuiles à terrasse comprend également des éléments porteurs pour la fixation du cadre avec la surface de sol.
Patent CA-3075940-A1 (CA)
Title: An intra-and circum-aural eeg brain computer interface
Inventor: VALENTIN OLIVIER
IPC: A61B5/0478
Filed: 2018-09-17
Abstract: An electroencephalography (EEG) based brain-computer interface for an ear of a user, the interface having a behind-the-ear piece with a flexible base. The flexible base is shaped to fit mostly behind the ear of a user and has at least one electrode positioned 5 to contact a skin covering a portion of a temporal bone of the user's skull. The flexible base also has a wedge that is shaped to contact an antihelical fold and/or concha of the ear in order to produce and maintain an adequate pressure and contact of the at least one of the plurality of electrodes on a portion of skin covering a temporal bone of the user's skull. The interface is adapted to produce voltage fluctuations measured by 0 the electrodes for determining a brain electrical activity. A system for determining a brain activity indicator using the electroencephalography (EEG) based brain-computer interface.
Patent CA-3076015-A1 (CA)
Title: Non-contact activity sensing network for elderly care
Inventor: COKE TANIA ALBEDIAN
IPC: A61B5/103
Filed: 2018-10-01
Abstract: Determining a physical state of a person includes detecting positions of different portions of the person, transforming detected positions of the person into a point cloud having a density that varies according to movement of each of the portions, correlating movement and position data from the point cloud with known physical state positions and transitions between different states, and choosing a particular physical state by matching the data from the point cloud with the particular physical state. Positions of different portions of the person may be detected using a tracking device. The tracking device may be a non-contact tracking device. The tracking device may include at least one wide band radar. The tracking devices may communicate wirelessly with at least one server in a cloud computing system. The states may include walking, standing, sitting, laying down, turning in bed, falling, and/or departed.
Patent CA-3076814-A1 (CA)
Title: Multi-source, flow-weighted composite sample system
Inventor: THOMPSON KENNETH O
IPC: G01N30/86
Filed: 2018-09-21
Abstract: A sampling device having at least two inputs each configured to receive samples from a corresponding feedstock input line and a sample accumulator. The device also includes a mass flow controller associated with each feedstock input line, each mass flow controller having a sample output and being configured to receive a signal representative of the flow rate at each input, where each mass flow controller adjusts the flow rate of its respective sample from its respective sample output in response to receiving representative signals. Further the device includes at least a first and second sample output line respectively connected with a sample output of each mass flow controller, each sample output line being connected to an input of the sample accumulator for introduction to the sample accumulator of samples from the output of the mass flow controllers.
Patent CA-3077957-A1 (CA)
Inventor: DOYLE JOSEPH GORDON
IPC: A24F40/50
Filed: 2020-04-17
Abstract: Vaporization devices, systems, and methods with automated thermal profile programming and control are disclosed. Thermal profile information associated with a particular vaporizable material is encoded to control the operation of the vaporizer and effectuate a heating and cooling profile that comports with a pre-selected thermal profile for the vaporizable material. The thermal profile is defined by a plurality of set points specified by power/temperature setting for a specified time. The thermal profile may be configured to be applied during a single inhalation or over multiple inhalations. The manufacturer or supplier of vaporization material (or another third party such as an expert in the field) may pre-select or otherwise control the thermal profile for a particular vaporization material and vaporizer via a thermal profile recipe code containing thermal profile information associated with the vaporizer cartridge and/or vaporizable material contained therein. The thermal profile information may be automatically read by the vaporizer or otherwise communicated to the vaporizer and used thereby to automatically control the vaporizer heating element to implement the desired thermal profile associated with the vaporization material. User controls/inputs and sensors are provided to facilitate adjustment or adaptation of a thermal profile, including to particular use conditions.
Patent CA-3079085-A1 (CA)
Inventor: GORIN CRAIG F
IPC: C09D5/03
Filed: 2018-10-22
Abstract: La présente divulgation concerne un procédé comprenant l'utilisation d'une dispersion aqueuse de polyoléfine ayant une teneur en matières solides de (50) à (90) % en poids, où la dispersion aqueuse de polyoléfine contenant des particules solides contient une polyoléfine comprenant un polymère à base d'éthylène ayant une température de fusion supérieure à (115)-(140) °C, une cire polyoléfinique, un dispersant acrylique ; et une phase aqueuse comprenant le dispersant acrylique en excédent ; l'ajout d'eau de dilution pour former une dispersion aqueuse de polyoléfine diluée ayant une teneur en matières solides de (5) à moins de (50) % en poids ; la collecte des particules solides ; le lavage des particules solides avec un agent de lavage pour éliminer le dispersant acrylique en excédent ; et l'élimination de l'agent de lavage pour former une poudre ayant une taille moyenne de particule en volume moyen de (10) à (300) µm, une sphéricité de (0,92) à (1,0), une distribution des tailles de particules de (1) à moins de (2), une densité de particules de (98) à (100) %, et un débit dans un grand entonnoir de (1) à (5) secondes.
Patent CA-3079097-A1 (CA)
Title: Asphalt emulsion surface treatment containing sterol
Inventor: REINKE GERALD H
IPC: E01C1/00
Filed: 2018-10-11
Abstract: Pavement aging can be reduced by applying to an asphalt-containing pavement a topcoat layer or a surface treatment containing asphalt binder emulsion with sterols.
Patent CA-3083095-A1 (CA)
Title: Systeme de manipulation et d'emballage de produits
Inventor: ALMOGY GILAD
IPC: B65G1/12
Filed: 2018-11-13
Abstract: Selon l'invention, des modes de réalisation de systèmes de manipulation de produits facilitent le transfert d'articles individuels de produit de la forme en vrac entrante dans des plateaux dédiés pour l'inspection, le tri, la sélection et l'emballage. L'inspection peut consister à interroger des articles de produit dans un plateau par des techniques électromagnétiques (par exemple, optiques, hyperspectrales) ou autres (par exemple, physiques, acoustiques, détection de gaz, etc.). Avant l'emballage, des articles de produit disposés dans le plateau peuvent être stockés dans un carrousel mobile responsable de la régulation de facteurs environnementaux tels que la température, l'humidité, l'éclairage, les gaz ambiants, les interactions entre produits et/ou autres. Le déplacement d'articles de produit d'une station de transfert de carrousel vers une position de présentation peut être accompli grâce à des robots et/ou des bandes transporteuses.. Des modes de réalisation peuvent permettre aux clients de sélectionner rapidement et à faible coût des articles de produit individuels spécifiques en fonction de leurs métadonnées associées (par exemple, source, identifiant) combinées avec les résultats de l'inspection (par exemple, apparence visuelle). Des modes de réalisation peuvent recevoir des articles de produit préemballés sous forme de plateau pour accélérer l'inspection, le tri, la sélection et l'emballage.
Patent CA-3083539-A1 (CA)
Title: Refrigeration system
Inventor: HUDSON JULIAN
IPC: F25B9/00
Filed: 2018-11-27
Abstract: Disclosed is a CO2 based refrigeration system comprising a condenser for transferring heat from a CO2 refrigerant of the refrigeration system to an air stream. The system further comprises an indirect evaporative cooler arranged to cool an air stream and supply the cooled air to the condenser to facilitate the transfer of heat from the CO2 refrigerant.
Patent CA-3084461-A1 (CA)
Inventor: KWON NAM HOON
IPC: A61K39/00
Filed: 2018-09-17
Abstract: The present invention relates to a novel use of an antibody binding specifically to the N-terminus of lysyl-tRNA synthetase and, more particularly, to a pharmaceutical composition comprising an antibody binding specifically to an epitope including the sequence of SEQ ID NO: 117 in the N-terminal domain of lysyl-tRNA synthetase (KRS) or a functional fragment thereof as an effective ingredient for preventing or treating an immune cell migration-related disease. A KRS N-terminus-specific antibody provided by the present invention can regulate the migration of immune cells, thereby exhibiting very remarkable effects in the prevention, alleviation, and treatment of immune cell migration-related diseases.
Patent CA-3085701-A1 (CA)
Inventor: ONO IKUMI
IPC: B32B33/00
Filed: 2018-12-14
Abstract: This layered body is provided with a metallic base layer and a transparent colored layer formed over the metallic base layer, where X=[(C*45)2+(C*75)2)]1/2 and Y=[(L*15)2+(C*15)2)]1/2+[(L*25)2+(C*25)2)]1/2, X is 64 or higher and Y is 191 or higher, and the measurement value (HG value) of perceived graininess is 45 or lower. (Where C*15, C*25, C*45, and C*75 represent chroma calculated from spectral reflectance of when light with which the layered body has been irradiated from a 45° incidence angle is received at an angle of 15°, 25°, 45°, or 75°, respectively, relative to regular reflected light; and L*15 and L*25 represent brightness calculated from spectral reflectance of when light with which the layered body has been irradiated from a 45° incidence angle is received at an angle of 15° or 25°, respectively, relative to regular reflected light.)