baber/WOPTO huggingface dataset:
Patent CA-3055669-A1 (CA)
Inventor: RINSCH CHRISTOPHER
IPC: A61P17/00
Filed: 2018-03-08
Abstract: The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prevention of a skin condition in a subject, wherein the compound of formula (I) or salt thereof is administered topically. The invention further provides topical compositons of a compound of formula (i) and processes for the preparation of said compositions.
Patent CA-3060911-A1 (CA)
Inventor: WAN CHUEN KWOON
IPC: C23C22/78
Filed: 2019-11-05
Abstract: ABSTRACT The present invention relates to a four-function steel surface treatment liquid and a preparation method thereof, the components of raw materials of the four-function steel surface treatment liquid per liter include: phytic acid of 15g-18g, hydroxyethylidene-1,l- diphosphonic acid of 50g- 65g, phosphoric acid solution of 280g-320g, manganous dihydrogen phosphate of 280g-360g, thiourea of 5g-8g, surfactant of 3g-6g, polyethylene glycol of lg-2g, sodium molybdate of 5g-8g, and the remaining of water. The four-function steel surface treatment liquid provided by the present invention has the advantages of a good anti-corrosion property and a safe cleaning process, is simple, high efficiency, environmental protection, no hydrogen embrittlement on a metal substrate, no intergranular corrosion, no harm to human skin, no burning, no explosion, and non-toxic, and can be used repeatedly at a normal temperature. CA 3060911 2019-11-05
Patent CA-3063718-A1 (CA)
Title: Combination therapies
Inventor: ORDENTLICH PETER
IPC: A61K31/4406
Filed: 2018-05-18
Abstract: The present disclosure relates to a combination of an anti-CSF-1R antibody or anti- CSF-1 antibody or antigen binding fragment thereof or an inhibitor of CSF-1R activity and an HDAC inhibitor, e.g., entinostat, and methods of using the combination for administering to subjects in need thereof for the treatment of cancer.
Patent CA-3064673-A1 (CA)
Title: Activating surfaces for subsequent bonding
Inventor: DEEGAN BRIAN
IPC: C08J7/12
Filed: 2018-06-06
Abstract: A method of activating a surface of a plastics substrate formed from: (a) polyaryletherketone such as polyether ether ketone (PEEK) polyether ketone ketone (PEKK), polyether ketone (PEK); polyether ether ketone ketone (PEEKK); or polyether ketone ether ketone ketone (PEKEKK); (b) a polymer containing a phenyl group directly attached to a carbonyl group, optionally wherein the carbonyl group is part of an amide group, such as polyarylamide (PARA); (c) polyphenylene sulfide (PPS); or (d) polyetherimide (PEI); for subsequent bonding, the method comprising the step of exposing the surface to actinic radiation wherein the actinic radiation: includes radiation with wavelength in the range from about 10 nm to about 1000 nm; the energy of the actinic radiation to which the surface is exposed is in the range from about 0.5 J/cm2 to about 300 J/cm2. Hard to bond substrates are then more easily subsequently bonded for example using acrylic, epoxy or anaerobic adhesive.
Patent CA-3068415-A1 (CA)
Title: Converter provided with a module for managing power in alternating part
Inventor: SHINODA KOSEI
IPC: H02M1/08
Filed: 2018-07-04
Abstract: The invention relates to a multi-level modular converter (10) provided with a control module (20) comprising a computer (22) to calculate an internal control setpoint of the converter and an energy management module (24) allowing a power setpoint to be determined that is to be transmitted to the alternating electrical power supply network (110), the control module being configured to regulate the voltage at the point of connection of the converter to the direct electrical power supply network (120) and to regulate the voltage at the terminals of each capacitor modelled as a function of the internal control setpoint and of the power setpoint to be transmitted to the alternating electrical power supply network.     calculateur (22) d'une consigne de commande interne du convertisseur et un module de gestion de l'énergie (24) permettant de détermmer une consigne de puissance à transmettre au réseau d'alimentation électrique alternatif (110), le module de contrôle étant configuré pour réguler la tension au pomt de connexion du convertisseur au réseau d'alimentation électrique contmu (120) et la tension aux homes de chaque condensateur modélisé en fonction de la consigne de commande interne et de la consigne de puissance à transmettre au réseau d'alimentation électrique alternatif
Patent CA-3071609-A1 (CA)
Inventor: SETH SANDESH
IPC: A61K51/10
Filed: 2018-07-31
Abstract: Pharmaceutical compositions comprising a radionuclide labelled monoclonal antibody against CD38, and methods of treating a hematological malignancy, inhibiting growth and/or proliferation of a cell expressing CD38, or treating a disease or disorder involving cells expressing CD38 are disclosed. An exemplary monoclonal antibody includes daratumumab labelled with acitinium (225Ac).
Patent CA-3071950-A1 (CA)
Inventor: NOCERA JR
IPC: C08H8/00
Filed: 2018-08-06
Abstract: Systems and methods for extracting useful by-products and natural rubber from non-Hevea rubber bearing plants are disclosed.
Patent CA-3074287-A1 (CA)
Inventor: PENG BIN
IPC: G05D1/10
Filed: 2017-05-22
Abstract: A flight control method and device of an Unmanned Aerial Vehicle (UAV), and a UAV. The method includes that: a flight track of the UAV is determined (101);  a remote control signal sent by a remote control apparatus is received (102); the remote control signal is converted into a flight controlled quantity of the UAV (103); a flight adjustment controlled quantity of the UAV is generated according to the current location, the flight track and the flight controlled quantity, of the UAV (104); and a flight mission is executed according to an action indicated by the flight adjustment controlled quantity, as to enable the UAV to run on the flight track (105). When the flight of the UAV is manually controlled by using the remote control apparatus, according to a transverse adjustment controlled quantity, that the UAV does not yaw but flies on the correct track all the time in the case of a long flight can be ensured, thereby improving the flight accuracy.
Patent CA-3077365-A1 (CA)
Inventor: Moutray Brad James
IPC: F17C13/06
Filed: 2018-10-29
Abstract: A boss assembly (28) for a pressure vessel (10) includes a boss (30), a fitting (32), a first seal (60b) and a second seal (60a). The boss (30) includes a bore (26) with an inner surface and a first stop feature (36). The fitting (32) is configured for at least partial insertion into the boss (30) to prevent fluid communication between an interior (17) and an exterior (19) of the pressure vessel (10), the fitting (32) including an outer surface (70) and a second stop feature (38). Each of the first (60b) and second (60a) seals is positioned along the outer surface (70). The fitting (32) is movable between first and second positions. In the first position, the first seal (60b) is sealingly engaged between the inner (26) and outer (70) surfaces and the second seal (60a) is not sealingly engaged therebetween. In the second position, the first seal (60b) is not sealingly engaged between the inner (26) and outer surfaces (70), the second seal (60a) is sealingly engaged, and the first (36) and second (38) stop features mutually contact.
Patent CA-3079073-A1 (CA)
Title: Herbicide compositions and methods of controlling growth of plants
Inventor: ST GERMAIN TIMOTHY
IPC: A01N35/06
Filed: 2020-04-15
Abstract: Herbicide compositions and methods effective in controlling growth of plants are described herein. The herbicide compositions include an herbicidally effective amount of (N)R-1,4-naphthaquinone or an agriculturally acceptable salt thereof, wherein N is of the value 2-5 and R is a functional group.
Patent CA-3080630-A1 (CA)
Inventor: PEREZ DIAZ JOSE LUIS
IPC: A61L9/015
Filed: 2018-10-22
Abstract: The present invention relates to a system, and the method of application thereof, for washing and decontamination comprising nebulizing means (8) of a mixture of at least one first gas and at least one first liquid, and pressurizing means (1) of said first gas, wherein said pressurizing means (1) are in fluid communication with a first pressure-regulating valve (3) and with a second pressure-regulating valve (4), the first pressure-regulating valve (3) being in fluid communication with a first pressurized tank (5) through first inlet means (31) of said first gas, the first pressurized tank (5) being configured to contain the first liquid, and comprising first outlet means (30) of said first liquid to the nebulizing means (8) through a first valve (6), at a first pressure that is greater than atmospheric pressure, and wherein the second pressure-regulating valve (4) is in fluid communication with said nebulizing means (8), and is configured to pressurize the gas at a second pressure that is greater than atmospheric pressure.
Patent CA-3081004-A1 (CA)
Inventor: GOJKOVIC MARK
IPC: H02K1/06
Filed: 2020-05-20
Abstract: Un actionneur dengrenage de prise directe et une méthode dentraînement dun rotor par rapport à un stator sont décrits, lesquels ne nécessitent pas de boîte dengrenages, mais sont capables de produire des couples de démarrage élevés instantanément, ce qui offre de grands avantages à la performance du système. Lactionneur comprend des réseaux de pôle de rotor et de stator fixés en relation espacée, qui offre un actionneur sans contact pour réduire lusure et lentretien. Une structure de contrôle intègre des pièces électroniques pour la commutation précise de lactionneur. Plus précisément, chaque réseau de pôle est contrôlé par un circuit de commande ou un contrôleur de pôle consacré pour permettre le contrôle précis du sens et de la force du champ magnétique. Chaque réseau de pôle peut sélectivement recevoir de lénergie en réponse à son contrôleur de pôle pour contrôler précisément les forces magnétiques de chaque pôle indépendamment des autres pôles dans le réseau.
Patent CA-3081456-A1 (CA)
Inventor: BURLEIGH STEPHEN MICHAEL
IPC: C12N15/113
Filed: 2018-11-01
Abstract: CRISPR/CAS-related genome editing systems, compositions and methods for targeting the TGFBR2 locus, as well as cells edited using these systems, compositions and methods are provided.
Patent CA-3082716-A1 (CA)
Title: Compositions for enhancing immune function of t cells and preparation methods therefor
Inventor: ZENG GUCHENG
IPC: C12N1/00
Filed: 2017-12-26
Abstract: Provided is a composition comprising Bacteroides fragilis. The composition is used for enhancing the immune function of the T cells in a body or for preventing and/or treating tumors.
Patent CA-3083140-A1 (CA)
Inventor: GARNIS CATHERINE
IPC: C12Q1/6809
Filed: 2018-11-30
Abstract: The present disclosure provides a method for diagnosing a head and neck cancer in a subject. The method comprises the steps of: a) measuring an expression level of miR- 125b or miR-342 and miR-125b in a sample from the subject; b) measuring an expression level of a normalizing miR in the sample and normalizing the measured expression level of miR-125b or miR-342 and miR-125b using the measured expression level of the normalizing miR; and c) diagnosing a head and neck cancer in a subject having a normalized measured expression level of miR-125b elevated relative to a reference expression level of miR-125b or having a ratio of normalized measured expression level of miR-342 to normalized measured expression level of miR-125b reduced relative to a reference ratio of expression level of miR-342 to expression level of miR-125b. Uses and kits associated with the herein disclosed methods are also disclosed.
Patent CA-3083495-A1 (CA)
Title: Gestion thermique de points d'acces sans fil
Inventor: MCFARLAND WILLIAM
IPC: H04W52/42
Filed: 2018-11-30
Abstract: L'invention concerne la gestion thermique de points d'accès sans fil comprenant une gestion thermique locale, une gestion thermique basée sur le nuage et une gestion thermique basée sur l'optimisation et le fonctionnement comme dans un réseau Wi-Fi distribué. L'objet de la présente invention est, pour la gestion thermique dans des points d'accès compatibles avec des petits facteurs de forme et des conceptions esthétiques, de prévenir la surchauffe, sans impliquer de réduction des performances ou du matériel. De manière générale, les systèmes et les procédés comprennent les opérations consistant à détecter lorsque des points d'accès approchent de la surchauffe et modifier leur fonctionnement de façon à minimiser la réduction des performances dans le réseau tout en réduisant la consommation d'énergie.
Patent CA-3084007-A1 (CA)
Inventor: TALLMAN RICHARD D
IPC: G09B23/00
Filed: 2018-01-01
Abstract: A system, method, and apparatus for a patient simulator that interacts with a diagnostic or therapeutic medical device. The system includes a computing device coupled to a patient module. The patient module includes hydraulic equipment that simulates a baseline fluid interconnection with a therapeutic device. The computing device manages physical and virtual data, provides algorithmic calculations for simulating hypothetical patient vital signs, long-term clinical course, and simulates related fluid properties. The simulation system automatically executes a step-wise clinical scenario, specified in a spreadsheet format of patient conditions and equipment scenarios, that also includes audio/visual stimuli of operating room and diagnostic clinic environments, along with data recording capabilities. The therapeutic device can be a heart lung machine (HLM), an extracorporeal membrane oxygenation (ECMO) machine, an emergency cardiac life support (ECLS) device, a ventricular assist device (VAD), a dialysis machines, a hyperthermic intraperitoneal chemotherapy (HIPEC) machine, and an aortic balloon pump.
Patent CA-3088503-A1 (CA)
Title: System and method for star and mesh communications within a very small aperture terminal system
Inventor: LE NINH
IPC: H04W72/02
Filed: 2018-06-20
Abstract: A mesh receiver, computer readable storage medium and method for a very small aperture terminal (VSAT) performing communications in a satellite-based network. The mesh receiver includes a receiver that receives a plurality of TDMA mesh carriers simultaneously in the network in plural channels. The mesh carriers have a transmitted frequency, transmitted gain, and transmitted timing that is unknown to the mesh receiver. The mesh receiver also includes circuitry configured to blindly derive gain, frequency, and timing values from the received mesh carriers, and a demodulator that demodulates the received TDMA mesh carriers and generates demodulated bursts for packets of the communications based on the blindly derived gain, frequency, and timing values.
Patent CA-3090552-A1 (CA)
Inventor: EDE NICHOLAS
IPC: A61K38/16
Filed: 2019-02-07
Abstract: Disclosed herein is a vaccine composition for raising a humoral response to PD1, and uses thereof, for treating a cancer characterised by an involvement of PD1, wherein the vaccine composition comprises an effective amount of an immunogen that induces an antibody response in which the antibody binds to a B cell epitope of PD1.
Patent CA-3091644-A1 (CA)
Inventor: OKO WALTER J
IPC: A61L2/26
Filed: 2019-02-20
Abstract: The present disclosure provides advantageous tray and bracket assembly that is configured and adapted to promote modularity and withstand the harsh environment of central sterile processing processes. Modular bracket assembly may be removed and relocated on tray without additional fasteners or components. Tray and bracket assembly may further provide identification features to correctly associate cataloged reusable medical devices to identified trays.
Patent CA-3094618-A1 (CA)
Inventor: O'BRIEN ROBERT
IPC: E21B23/04
Filed: 2019-03-21
Abstract: Le déclencheur d'actionnement selon l'invention comprend un boîtier ; un piston en communication fonctionnelle avec le boîtier ; une entrée de source de pression vers le déclencheur, le piston étant sensible à des cycles de pression source ; un premier élément d'incrémentation axiale dans une direction, mobile avec le mouvement du piston ; une tige mobile avec le piston et qui est limitée en position par l'élément d'incrémentation axiale dans une direction, la tige faisant initialement partie d'un joint dynamique qui empêche la pression d'actionnement d'accéder à un outil pouvant être actionné par ladite pression.
Patent CA-3096075-A1 (CA)
Inventor: VIEIRA MIGUEL
IPC: B65D83/42
Filed: 2019-04-05
Abstract: L'invention concerne un col (10) pour une préforme en plastique ainsi qu'un récipient approprié pour contenir des contenus pressurisés et comprenant un anneau (12), un segment supérieur (14), une bride (16) et un segment inférieur (18). Le segment supérieur (14) est disposé verticalement entre la bague (12) et la bride (16) et le segment inférieur (18) est disposé verticalement au-dessous de la bride (16). Un segment de paroi radiale interne (22) de l'anneau (12) d'un col (10) est décalé radialement vers l'extérieur à partir d'un segment de paroi radiale interne (24) du segment supérieur (14). Dans des modes de réalisation, le récipient en plastique comprend une fermeture (30) et peut être configuré pour conserver et distribuer des contenus sous pression.
Patent CA-3098916-A1 (CA)
Inventor: MAS FANNY
IPC: C22C21/18
Filed: 2019-04-24
Abstract: L'invention concerne un procédé de fabrication dans lequel on prépare un alliage comprenant 3,5 à 4,7 % en poids de Cu; 0,6 à 1,2 % en poids de Li; 0,2 à 0,8 % en poids de Mg; 0,1 à 0,2 % en poids de Zr; 0,0 à 0,3 % en poids d'Ag; 0,0 à 0,8 % en poids de Zn; 0,0 à 0,5% en poids de Mn; au plus 0,20 % en poids de Fe + Si; optionnellement un élément choisi parmi Cr, Sc, Hf et V, la quantité dudit élément, s'il est choisi, étant de 0,05 à 0,3 % en poids pour Cr et pour Sc, 0,05 à 0,5 % en poids pour Hf et pour V; autres éléments au plus 0,05% en poids chacun et 0,15% en poids au total, on introduit un affinant, on coule sous une forme brute, on homogénéise, déforme à chaud, met en solution, trempe, déforme à froid et réalise un revenu, dans lequel l'affinant contient des particules de TiC et/ou la déformation à froid est comprise entre 8 à 16%. Les produits obtenus par le procédé selon l'invention présentent un compromis avantageux entre résistance mécanique et ténacité.
Patent CA-3100592-A1 (CA)
Inventor: KO KWON CHEUL
IPC: A61M5/50
Filed: 2019-09-30
Abstract: A reuse prevention safety catheter is proposed. The reuse prevention safety catheter includes: a catheter hub having an external needle disposed therein; a cannula plug having an internal needle inserted and penetrated into the catheter hub disposed therein to introduce the external needle into a blood vessel and be separated from the catheter hub; and a locking guide unit having a through-hole configured to allow the internal needle to pass through, wherein the through-hole is deformed when the penetrated internal needle is withdrawn, such that re-penetration of the internal needle is blocked.
Patent CA-3102051-A1 (CA)
Inventor: AGUILERA RENATO
IPC: A61K31/395
Filed: 2019-06-19
Abstract: La présente invention concerne l'utilisation de compositions bifonctionnelles dans des procédés de traitement ou de prévention du cancer. Les compositions comprennent un ligand d'ADN et un ligand de protéine pour le traitement ou la prévention du cancer, le ligand d'ADN interférant avec le métabolisme de l'ADN et le ligand de protéine interférant avec des voies de signalisation. En particulier, la présente invention concerne l'utilisation de la pyronaridine dans des procédés de traitement de prévention du cancer. L'invention concerne également des compositions, des composés et des médicaments comprenant un ligand d'ADN et un ligand de protéine, par exemple des compositions, des composés et des médicaments comprenant de la pyronaridine.
Patent CA-3102138-A1 (CA)
Title: Determining peripheral oxygen saturation (spo2) and hemoglobin concentration using multi-spectral laser imaging (msli) methods and systems
Inventor: TUCKER BRYENT
IPC: A61B5/00
Filed: 2019-06-06
Abstract: Some embodiments of the present inventive concept provide a multispectral imaging system including a first light source, the first light source having a first wavelength configured to produce a non-coherent illumination to image a sample; a second coherent light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample simultaneously with the first light source; a camera configured to simultaneously receive information related to the first and second light sources from the sample, wherein light at the first wavelength is configured to image a surface of the sample into the camera and light at the second wavelength is configured to penetrate the sample and provide information related to the penetrated sample to the camera; and a processor configured to combine the received information related to the first and second light sources and generate a synthesized image of the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of blood flow rate distribution.
Patent CA-3102434-A1 (CA)
Title: Selective a2a receptor antagonist
Inventor: WANG ZAIQI
IPC: C07D487/14
Filed: 2019-06-03
Abstract: The present invention relates to a selective A2A receptor antagonist, and in particular to a selective A2A receptor antagonist of Formula (l) which is a 5-amino-7-(2-phenyl-Cn-alkyl)-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine, a pharmaceutical composition comprising the antagonist, use of the antagonist in manufacturing a medicament and in treatment of a disease:    wherein the groups in Formula (l) are defined as in the specification.
Patent CA-3106162-A1 (CA)
Title: Procedes d'obtention d'une specificite elevee d'edition genomique
Inventor: WANG JIWU
IPC: C12N9/22
Filed: 2019-07-12
Abstract: L'invention concerne un procédé d'obtention d'altérations de séquences d'ADN hautement efficaces. Le procédé est utile pour éditer des chromosomes, pour modifier des marqueurs cellulaires par insertion de gènes, ou pour créer des variations épigénétiques en utilisant des fusions d'enzymes-Cas9, les enzymes pouvant être des enzymes de modification épigénétique d'ADN ou des enzymes de modification de la chromatine, etc. La technologie diffère également de toutes les technologies connues jusqu'ici en ce que le système CRISPR/Cas peut fonctionner de manière « propre », c'est-à-dire qu'il n'a été en contact avec aucun virus, ou qu'il transporte des molécules d'ADN qui peuvent être insérées dans le chromosome dans des emplacements non souhaités.
Patent CA-3108840-A1 (CA)
Title: Composes utiles dans le traitement et/ou les soins de la peau, des cheveux, des ongles et/ou des membranes muqueuses
Inventor: DELGADO RAQUEL
IPC: A61K9/06
Filed: 2019-08-09
Abstract: La présente invention concerne un composé de formule (I) R1 - Wm-Xn- AA1- A A2- A A3- AA4- A A5- AA6-Yp-Zq-R2, un stéréoisomère et/ou un sel cosmétiquement acceptable de celui-ci, dans la formule : AA1 est Arg, Lys ou pas d'acide aminé; AA2 est Arg ou Lys; AA3 est Gln, Glu, Asn ou Asp; AA4 est Met ou Leu; AA5 est Glu, Asp ou Gin; AA6 est Glu, Asp, Gin ou pas d'acide aminé; et AA1 est différent de AA6. Les composés sont utiles pour le traitement et/ou la prévention des symptômes du vieillissement de la peau et, en particulier, pour le traitement et/ou la prévention de rides cutanées, le traitement et/ou la prévention d'un aspect d'affaissement de la peau, et/ou la réduction et/ou la prévention de l'asymétrie faciale.