Patent SG-11201909718Q-A (SG)
Title: Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
Inventor: NELLORE KAVITHA
IPC: A61P35/00
Filed: 2018-04-19
Abstract: FIGC 2 0 2 0.01 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT o mons °nolo Dill mcino Imo oimIE (10) International Publication Number WO 2018/197997 Al (51) International Patent Classification: A61K 31/4192 (2006.01) A61K 31/5377 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) A61K 31/496 (2006.01) (21) International Application Number: PCT/IB2018/052710 (22) International Filing Date: 19 April 2018 (19.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/494,820 24 April 2017 (24.04.2017) US 15/899,707 20 February 2018 (20.02.2018) US (71) Applicant: AURIGENE DISCOVERY TECH- NOLOGIES LIMITED [IN/IN]; 39-40, KIADB Industri- al Area, Electronic City Phase II, Hosur Road, Karnataka, Bangalore 560100 (IN). (72) Inventors: NELLORE, Kavitha; B-502, Akme Ballet, Outer Ring Road, Doddanekundi, Karnataka, Bangalore 560037 (IN). HOSAHALLI, Subramanya; A 103, Temple Meadows, # 3, 27th Cross, Banashankari, 2nd Stage, Kar- nataka, Bangalore 560070 (IN). (74) Agent: SURAPUREDDY, Padmaja; spiProPAT Intellec- tual Property Solutions, 4th Floor, Above Apollo Clinic, Suresh Square, Plot No 1-58/91/SS, Survey No 228 & 229/1, Madinaguda, Miyapur Hyderabad 500 049 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) of inventorship (Rule 4.17(iv)) (54) Title: METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXY- GENATE INHIBITORS Compound 1 sensitivity across cell line panel 1-1 N 01 01 N 01 1-1 (57) : The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the 0 formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R which have the meanings given in the specification, and pharmaceutically acceptable salts thereof. 3 [Continued on next page] C WO 2018/197997 Al MIDEDIMOMMIDEFIEDEMEIMOIMOHMEMOIMIE Published: — with international search report (Art. 21(3))