baber/WOPTO huggingface dataset:
Patent NZ-526942-A (NZ)
Title: A process for preparing particles of a substance using an anti-solvent technique
Inventor: SUNDHOLM GORAN ERIC
IPC: A61K31/167
Filed: 2002-01-22
Abstract: A process for preparing particles of a substance comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid.
Patent NZ-531352-A (NZ)
Title: Novel compounds and compositions as cathepsin inhibitors
Inventor: GRAUPE MICHAEL
IPC: A61P13/12
Filed: 2002-09-16
Abstract: Compounds of Formula I are disclosed. These compounds are useful in the manufacture of a medicament for treating a disease in an animal in which Cathepsin S activity contributes to the pathology and/or symptomology of the disease. A process for preparing a compound of Formula I is also disclosed.
Patent NZ-531642-A (NZ)
Title: Cyclic indole and heteroindole derivatives, the production and use thereof as medicaments
Inventor: WEINBERGER HEINZ
IPC: A61K31/407
Filed: 2002-08-27
Abstract: Substituted, annelated indole and heteroindole derivatives of formula (I), tautomers, stereoisomers, mixtures and pharmaceutically acceptable salts thereof and the production and use thereof as medicaments, in particular as anti-tumour agents in mammals, in particular humans is disclosed, wherein the substituents are as defined in the specification.
Patent NZ-531932-A (NZ)
Title: Manipulation of chocolate flavour
Inventor: KOCHHAR SUNIL
IPC: A23G1/30
Filed: 2002-06-25
Abstract: Disclosed is a process for manipulating the flavour of a single mass of chocolate which comprises first reducing or removing the natural flavour form the chocolate ingredients or the chocolate mass and then adding an effective amount of a flavour to the chocolate mass. The flavour provides any of the following attributes cocoa/dairy, roasted, sweet, bitter, crumb, caramel, fruity, floral, biscuit, baked, bready, cereal, malty, popcorn, astringent or praline.
Patent NZ-549761-A (NZ)
Title: An improved shower system
Inventor: WILSON GARETH SCOTT
Filed: 2006-09-08
Abstract: A shower system is disclosed. The disclosure relates to an overhead shower with an exposed supply pipe extending up the wall from a mixer via an extension section and having an adjustable connector that allows the distance between the extension section and the surface of the wall to be adjusted.
Patent NZ-552012-A (NZ)
Title: Building system
Inventor: MADSON TYGE
IPC: E04B7/20
Filed: 2005-06-14
Abstract: A building panel has supports 22 and covers 14. One side 30 of the supports of one panel can be fitted to overlap and engage with the other side 32 of the supports of an adjacent panel, the overlapping corrugations serving to restrain movement of the panels out from engagement.
Patent NZ-556554-A (NZ)
Title: Jamb and sill flashing with compressible panel edge interface strip
Inventor: MCCLEW IAN KURT
IPC: E06B7/26
Filed: 2007-07-16
Abstract: A jamb or sill flashing 1 includes an elongate L-shaped member defining a flange arm 8 underlying the corrugated panel 10 with which the flashing is to be used, and a compressible strip 3, 4 fixed to and extending along the inside surface of the abutment arm 7 of the L-shaped member. The compressible strip has an exposed surface 12 into which the corrugated edge 11 of the panel or the straight edge of the panel is abutted. The compressible strip might be made of several layers 3, 4, 12 including a protective layer 12 on the exposed face, and part 3 of the strip may extend beyond the edge 6 of the abutment arm of the L-shaped member.
Patent NZ-567848-A (NZ)
Title: Short tapping machine
Inventor: BRUERTON RUSSELL
Filed: 2008-05-01
Abstract: A drilling or tapping machine, particularly for use in tapping pressurised mains lines, of reduced length is disclosed. The machine has an elongated housing with a front end through which a drill mounting stub (43) projects. A drill shaft (41) has an inner elongated drill tube with a splined bush at the rear end and with the mounting stub carried at the front end. A support tube is mounted coaxially but spaced from the drill tube, with front and rear bearing nuts mounting the support tube to the drill tube for relative rotation. A spline shaft (54) extends through the drill tube and is slidably engaged with the splined bush so that rotation of the spline shaft rotates the drill tube in the housing. A moving plate is fixed to the rear end of a bearing nut and is movable axially relative to the spline shaft. The moving plate is adapted to engage the inner end of the drill tube to axially move the drill tube relative to the housing. A drive means rotates the spline shaft and a second drive means moves the moving plate in the axial direction.
Patent NZ-568306-A (NZ)
Title: Water purifaction by creating a hydration layer using an electrode and forcing this layer through a membrane
Inventor: STEFANINI DANIEL
IPC: C02F1/469
Filed: 2006-10-12
Abstract: Disclosed is an apparatus for purification treatment of water from a supply of water containing dissolved matter. The apparatus comprises at least one treatment surface in the form of a semi-permeable membrane (20) to which the supply water is delivered, and means for subjecting the supply water to pressure to cause reverse osmotic flow of water through the membrane. The membrane has an adjacent electrode (22) to which a voltage is applied for locating an electric field in the supply water, thereby establishing, at the electrode a hydration layer of water from which is caused to flow through the membrane by the applied pressure.
Patent NZ-568331-A (NZ)
Title: Environmental brush seal
Inventor: MATTICE DOUGLAS A
Filed: 2008-05-15
Abstract: A brush seal with particular application for protecting environments where pressure differentials may exist, such as elevator shafts or clean rooms, is disclosed. The seal comprises a strip brush with filaments that are polygonal in transverse section. The filaments have relatively sharp corners that create vortices or eddies as air flows past.
Patent NZ-571342-A (NZ)
Title: Dimers of artemisinin derivatives, preparation thereof and therapeutic use thereof
Inventor: COMMERCON ALAIN
IPC: A61K31/357
Filed: 2007-04-06
Abstract: Disclosed are dimers of artemisinin derivatives of formula (I) wherein the substituents are as defined in the specification, their preparation and their use in treating cancer.
Patent NZ-573478-A (NZ)
Title: Use of anti-TNFalpha antibodies
Inventor: KEMPENI JOACHIM
IPC: A61P17/02
Filed: 2002-06-05
Abstract: Provided is the use of an isolated human anti-TNFá antibody, or an antigen-binding portion thereof, in the manufacture of a medicament for treating a human subject having an autoimmune disease in which TNFá activity is detrimental, wherein the medicament is adapted for biweekly administration as a total body dose, and wherein the human anti-TNFá antibody, or antigen-binding portion thereof, has the following characteristics: a) dissociates from human TNFá with a koff rate constant of 1 x 10-3 s-1 or less, as determined by surface plasmon resonance; b) has light chain variable region (LCVR) comprising a CDR3 domain comprising a specified amino acid sequence, or modified from it by a single alanine substitution at position 1, 4, 5, 7, or 8, or by one to five conservative amino acid substitutions at positions 1, 3, 4, 6, 7, 8, and/or 9; and, c) has heavy chain variable region (HCVR) comprising a CDR3 domain comprising a specified amino acid sequence, or modified from it by a single alanine substitution at position 2, 3, 4, 5, 6, 8, 9, 10, or 11, or by one to five conservative amino acid substitutions at positions 2, 3, 4, 5, 6, 8, 9, 10, 11, and/or 12.
Patent NZ-581355-A (NZ)
Title: Potentiation of cancer chemotherapy by 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1h-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine
Inventor: ABURUB AKTHAM
IPC: A61K33/243
Filed: 2008-06-20
Abstract: Disclosed is 7-(2,5-dihydro-4-(imidazo[1,2-a]pyridine-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(piperidin-1-ylcarbonyl)-pyrrolo[3,2,1-jk][1,4]-benzodiazepine or a pharmaceutically acceptable salt or solvate thereof in combination with a chemotherapeutic agent selected from CPT-11, 5-fluorouracil, pemetrexed, gemcitabine, etoposide, doxorubicin, and platinum chemotherapeutic agents such as cisplatin or carboplatin; for use in the treatment of ovarian cancer, non-small cell lung cancer, colorectal cancer or gastric cancer.
Patent NZ-586830-A (NZ)
Title: 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
Inventor: BAXTER ELLEN
IPC: C07D409/14
Filed: 2009-01-29
Abstract: Disclosed is a compound of formula (I) wherein a is an integer from 0 to 4; R1 is selected from the group consisting of halogen, C1-4alkyl, C1-4alkoxy, halogenated C1-4alkyl and halogenated C1-4alkoxy; A is selected from the group consisting of aryl and heteroaryl; R2 is selected from the group consisting of hydrogen and C1-4alkoxy; R3 is selected from the group consisting of hydrogen, C1-8alkyl, hydroxyl substituted C2-8alkyl, NRARB substituted C2-8alkyl, -C1-4alkyl-O-C1-4alkyl, cycloalkyl, -(C1-4alkyl)-cycloalkyl, heterocycloalkyl and -(C1-4alkyl)heterocycloalkyl; wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-4alkyl; A1 is selected from the group consisting of -(CH2)b-; wherein b is an integer from 2 to 4; L1 is selected from the group consisting of-NRc- and -C(O)-NRc-; wherein RC is selected from the group consisting of hydrogen, C1-8alkyl, hydroxy substituted C1-4alkyl, -C1-4alkyl-O-C1-4alkyl and C5-7cycloalkyl; R4 is selected from the group consisting of C1-8alkyl, C2-12alkenyl, -C1-4alkyl-O-C1-4alkyl, -C1-4alkyl-NRDRE, -C1-4alkyl-OH, cycloalkyl, -C1-4alkylcycloalkyl, partially unsaturated carbocyclyl, -C1-4alkyl-(partially unsaturated carbocyclyl), aryl, aralkyl, heteroaryl, -C1-4alkyl-heteroaryl, heterocycloalkyl and -C1-4alkyl-heterocycloalkyl; wherein RD and RE are each independently selected from the group consisting of hydrogen and C1-4alkyl; and wherein the cycloalkyl, partially unsaturated carbocyclyl, aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of fluoro, C1-4alkyl, -C1-4alkyl-O-C1-4alkyl, carboxy, -C(O)O-C1-4alkyl and aralkyl; alternatively, L1 is -NRc- and RC and R4 are taken together with the nitrogen atom to which they are attached to form a ring structure selected from the group consisting of 1-pyrazolyl, 1-imidazolyl and 1-(1 ,2,3-triazolyl); wherein the 1-pyrazolyl, 1-imidazolyl or 1-(1,2,3-triazolyl) is optionally substituted with a substituent selected from the group consisting of C1-6alkyl; or a pharmaceutically acceptable salt thereof.
Patent NZ-587528-A (NZ)
Title: Practical modelling and acquisition layered facial reflectance
Inventor: DEBEVEC PAUL E
IPC: G05B13/02
Filed: 2009-02-02
Abstract: Techniques are described for modeling layered facial reflectance consisting of specular reflectance, single scattering, and shallow and deep subsurface scattering. Parameters of appropriate reflectance models can be estimated for each of these layers, e.g., from just 20 photographs recorded in a few seconds from a single view-point. Spatially-varying specular reflectance and single-scattering parameters can be extracted from polarization-difference images under spherical and point source illumination. Direct-indirect separation can be employed to decompose the remaining multiple scattering observed under cross-polarization into shallow and deep scattering components to model the light transport through multiple layers of skin. Appropriate diffusion models can be matched to the extracted shallow and deep scattering components for different regions on the face. The techniques were validated by comparing renderings of subjects to reference photographs recorded from novel viewpoints and under novel illumination conditions. Related geometry acquisition systems and software products are also described.
Patent NZ-589235-A (NZ)
Title: Radially compressible blood control valve
Inventor: MCKINNON AUSTIN JASON
IPC: A61M39/00
Filed: 2009-03-12
Abstract: 589235 An apparatus (100) to control blood flow through an intravenous catheter is disclosed. The apparatus comprises an intravenous catheter adapter (102) having a hollow interior region (108) therein. A blood control valve (112) is positioned within the hollow interior region having a hollow resilient outer shell and an inner valve forming a proximal end of the outer shell. The inner valve further comprises a slit configured to open upon translating the blood control valve (112) into a second portion of the interior region to compress the outer shell.
Patent NZ-590274-A (NZ)
Title: Stable crystal modifications of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)
Inventor: PLATSCHER MICHAEL
IPC: C30B7/08
Filed: 2009-05-13
Abstract: Disclosed are crystalline (R,S)-, (R)- or (S)- forms of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) having 2 theta values of 3.6, 5.3, 18.3, 19.3 and 21.7. Further disclosed is a process for the preparation of crystal modifications of the specified crystalline form of DOPC, the use of the crystalline DOPC as a constituent for the preparation of a medicament, and a pharmaceutical composition comprising crystal modifications of DOPC.
Patent NZ-596813-A (NZ)
Title: Drug delivery systems
Inventor: BIANCHI MARZIA
IPC: A61K9/00
Filed: 2010-06-07
Abstract: 596813 Disclosed is a modified red blood cell wherein the modification consists of an association complex consisting of a drug and a recombinant carrier protein for the drug, wherein the uncomplexed form of the drug is capable of readily passing the red blood cell membrane and wherein the uncomplexed recombinant carrier protein, owing to its size, cannot readily pass the red blood cell membrane. Further disclosed is a modified red blood cell containing a carrier protein that cannot readily pass the red blood cell membrane and which can form an association complex with a target drug, the uncomplexed form of the drug being capable of readily passing the red blood cell membrane, wherein the carrier protein, or a functional analogue thereof, is recombinant or occurs in wild type red blood cells and is present at elevated levels.
Patent NZ-597221-A (NZ)
Title: Tape drape with cuffs or pockets typically for universal c arm
Inventor: ADAMS TAMMY COLVIN
IPC: A61B19/02
Filed: 2010-08-20
Abstract: A drape, such as but not limited to, a drape that can be used to cover a C arm of a medical device is provided. The drape includes material, at least one cuff and at least one adhesive strip. The material has a select property and has a select shape. The at least one cuff is formed along at least one edge of the material. The at least one cuff is configured to allow manipulation of the drape by a user. The at least one adhesive strip is configured to selectively adhere the drape to a surface to be covered by the drape.
Patent NZ-599789-A (NZ)
Title: Aerosol generator including multi-component wick
Inventor: YANG ZUYIN
IPC: A61L9/03
Filed: 2010-10-11
Abstract: Disclosed is an aerosol generator for an electronic cigarette that can vary the composition of the volatile liquid. The aerosol generator comprises a composite conduit 1, 2, 3 to transport multiple liquids 5, 6 to a heating element 7 at flow rates such that the liquids 5, 6 arrive at the heating element 7 in desirable concentrations, the composite conduit 1, 2, 3 comprising a plurality of passages having different lengths. The heating element 7 is operable to volatilize the multiple liquids 5, 6 to form volatilized fluid, which mixes with ambient air to form an aerosol with desirable concentrations of the multiple liquids 5, 6. The composition of the aerosol is determined by the rates of transport of the multiple liquids by the composite conduit to the heating element. The multiple liquids comprise a combination of hydrophobic, hydrophilic and neutral liquids and in which the generator comprises a first wick is of a material having an affinity to the hydrophilic liquid; a second wick is of a material having an affinity to the hydrophobic liquid; a third wick is of a material having an affinity to the neutral liquid.
Patent NZ-601012-A (NZ)
Title: Pen with rotatable end cap to extend or retract tip
Inventor: HAMPTON MARK ROSS
IPC: B43K7/00
Filed: 2012-07-02
Abstract: A writing instrument (1) in four parts. The writing instrument includes: a) a first ink cartridge (2), the first ink cartridge having a writing tip (3) at a first end (4) thereof; b) a cartridge holder (5) for attachment to a second end (6) of the first ink cartridge; c) a body portion (8) for receiving the cartridge holder and the first ink cartridge; d) an end cap (11) for engaging with the guide by means of a releasable snap fit mechanism. The body portion forms part of the exterior body of the writing instrument. A first end (9) of the body portion includes a guide (10) for releasably locating the cartridge holder, the guide being adapted to prevent rotation of the cartridge holder with respect to the body portion. The end cap forms part of the exterior body of the writing instrument. The end cap overlaps with a portion of the guide and/or the remainder of the body portion so that there is a substantially rigid and/or robust connection between the end cap and the body portion. The arrangement and construction is such that rotating the end cap relative to the body portion (or vice versa) has the effect of extending and/or retracting the writing tip of the first ink cartridge from a second end (12) of the body portion.
Patent NZ-602600-A (NZ)
Title: A concealed fixing retaining clip for roof cladding sheets with profiled ribs
Inventor: GALLATY RODNEY JOHN
IPC: E04D3/36
Filed: 2011-03-29
Abstract: A concealed fixing retaining clip for fixing a roof or other cladding sheet to an underlying support structure is disclosed. The clip comprises a base, a pair of side walls that extend from the base, and a pair of flanges that define retaining members for engaging re- entrant portions in the sides of ribs of cladding sheets. The flanges define arches that extend outwardly and downwardly from upper ends of the side walls. The flanges are mirror images of each other about a centreline plane that passes perpendicularly through the base. Each flange may have a stiffener on each side of a centreline of the flange. The side walls may include in-turned side edges that improve the rigidity of the side walls.
Patent NZ-609916-A (NZ)
Title: Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof
Inventor: WEINSCHENK TONI
IPC: C07K14/705
Filed: 2011-11-14
Abstract: Disclosed is a composition comprising at least two HLA-binding peptides selected from: (a) at least one of a peptide comprising an epitope according to SEQ ID NO: 23, or a peptide comprising an epitope according to SEQ ID NO: 23 fused to the 80 N-terminal amino acids of the HLA-DR antigen-associated invariant chain; and (b) at least one of a peptide comprising an epitope selected from the group consisting of: SEQ ID NO: 1 to SEQ ID NO: 11, SEQ ID NO: 13 to SEQ ID NO: 22, and SEQ ID NO: 24 to SEQ ID NO: 42, wherein said peptides of (a) and (b) have an overall length of between 8 and 30 amino acids, wherein the sequences are as defined in the complete specification. Further disclosed is the use of said composition for the preparation of a medicament for the treatment of prostate cancer.
Patent NZ-617749-A (NZ)
Title: Geothermal binary cycle power plant with geothermal steam condensate recovery system
Inventor: KAPLAN URI
IPC: F24J3/08
Filed: 2012-04-16
Abstract: A geothermal based, binary cycle power plant is provided, comprising: a vaporizer for vaporizing pre-heated organic motive fluid by means of geothermal steam; two organic vapor turbines operating in parallel and coupled to a common generator, each of said turbines being driven by vaporized organic motive fluid supplied to each turbine; two recuperators for heating the organic motive fluid by means of a corresponding organic vapor turbine discharge; and two condensers for condensing heat depleted motive fluid exiting said two recuperators, respectively. A geothermal steam condensate recovery system is also provided, comprising a source of geothermal steam for vaporizing a organic motive fluid and producing geothermal steam condensate, and conduit means through which geothermal steam condensate is delivered to a supply of cooling liquid used to condense the organic motive fluid, the delivered geothermal steam condensate serving as make-up liquid for evaporated cooling liquid.
Patent NZ-707873-A (NZ)
Title: Renal cell populations and uses thereof
Inventor: BASU JOYDEEP
IPC: C07K16/18
Filed: 2013-10-24
Abstract: The present invention is useful for regenerative therapy of the kidney for the treatment of kidney disease. In an aspect, provided herein is a method of identifying a heterogeneous renal cell population suitable for implantation and/or eliciting a regenerative response, the method including isolating cells from a mammalian kidney sample; exposing the isolated cells to labeled detection moieties for biomarkers, wherein each labeled detection moiety comprises an antibody, is labeled, and is directed to a different biomarker, wherein the biomarkers comprise GGT-1, a cytokeratin, VEGF, and KIM-1; and determining the percentage of cells that express each of said different biomarker. Also provided are uses of a heterogeneous renal cell population in preparing a composition for treating kidney disease in a mammal, wherein cells from the heterogeneous renal cell population have been identified as suitable for implantation and/or eliciting a regenerative response according to a method disclosed herein.
Patent NZ-711210-A (NZ)
Title: Combination therapy for neoplasia treatment
Inventor: ADAM PAUL
IPC: A61K39/395
Filed: 2014-03-06
Abstract: The present invention relates to an insulin-like growth factor (IGF) receptor antagonist for use in the treatment of prostate neoplasia, including benign prostatic hyperplasia (BPH), prostate cancer, and particularly CRPC, wherein the antagonist is used in combination with an androgen receptor antagonist. An embodiment of the invention is where the androgen receptor antagonist is enzalutamide.
Patent NZ-717595-A (NZ)
Title: Methods and tools relating to the administration of contrast medium
Inventor: COUDYZER WALTER
IPC: A61M31/00
Filed: 2014-09-18
Abstract: Envisaged herein are methods for determining the optimal volume of contrast medium to be administered to a patient. More particularly, the methods envisaged herein comprise the steps of (a) measuring one or more patient-specific physiological parameters, said one or more patient-specific physiological parameters comprising at least the patient’s heart rate; and (b) determining the optimal volume of contrast medium based on the patient-specific physiological parameters determined under (a).
Patent NZ-721544-A (NZ)
Title: Factor viii chimeric proteins and uses thereof
Inventor: KULMAN JOHN
IPC: A61K38/36
Filed: 2015-01-09
Abstract: The present invention provides a chimeric protein comprising a first polypeptide which comprises a FVIII protein and a first Ig constant region or a portion thereof and a second polypeptide which comprises a VWF protein comprising the D’ domain and D3 domain of VWF, a XTEN sequence having less than 288 amino acids in length, and a second Ig constant region or a portion thereof, wherein the first polypeptide and the second polypeptide are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.