baber/WOPTO huggingface dataset:
Patent MY-196010-A (MY)
Title: Volume Measurement Apparratus
Inventor: GILLETT NICHOLAS ROSS
IPC: G01F25/00
Filed: 2016-08-08
Abstract: A volume measurement apparatus (10) for a storage container, comprising an elongated member (12) having a measurement scale (18) marked thereon and an attachment mechanism (22) configured to attach the elongated member (12) onto a storage container, wherein the storage container is capable of holding a liquid or granular substance. The volume measurement apparatus (10) further comprises an adjustment mechanism (34) configured such that a position and orientation of the elongated member (12) can be adjusted relative to the storage container to align a minimum or maximum capacity marker on the measurement scale (18) with a topmost level of the substance held in the storage container. The measurement scale (18) is adapted such that it can be used to measure a volume of the substance held in the storage container.
Patent MY-174163-A (MY)
Title: Sacrificial electrode attachment structure and electrolytic apparatus including the same
Inventor: OTSU HIDEO
Filed: 2017-06-09
Abstract: A sacrificial electrode attachment structure (20, 40, 60) includes: a first pipe (14, 15, 34, 35) in which electrolyte flows; a second pipe (13, 33) which is formed of an insulating material and allows the electrolyte (L) to flow; a cylindrical sacrificial electrode unit (22, 42) arranged between the first pipe and the second pipe so as to allow the electrolyte to flow, and including a sacrificial electrode (22c, 42c) that contacts the electrolyte; a first pipe joint (23, 43) adapted to liquid-tightly connect the first pipe to the sacrificial electrode unit in a detachable manner; and a second pipe joint (24, 44, 64) adapted to liquid-tightly connect the second pipe to the sacrificial electrode unit in a detachable manner.
Patent MY-194012-A (MY)
Title: Flat knitting machine
Inventor: LAN SHANBING
IPC: D04B15/56
Filed: 2018-08-03
Abstract: A flat knitting machine comprises a main frame (1), a needle selection system (2), a slide rail assembly (13), a head component (3), shuttle assemblies, a yarn shearing device (5) and a separation system (6), wherein the needle selection system (2) comprises a roller mechanism, and two rollers (22) of the roller mechanism are connected with independent driving devices (14) through leads screws so as to be driven; the slide rail assembly (13) is arranged above the needle selection system (2); the head component (3) is arranged on the slide rail assembly (13) and comprises a front head assembly (31) and a rear head assembly (32), the rear head assembly (32) is connected with an independent driving device (14) to reciprocate horizontally, and the front head assembly (31) is connected with the rear head assembly (32) through a head connecting device (33); the shuttle assemblies are mounted at the upper end of the head component (3) and are intermittently driven by the head component (3); the yarn shearing device (5) is connected with an independent diving device to be driven; and the separation system (6) comprises a fork component (61) and a shear component (62). The flat knitting machine is simple in design structure, light and flexible, has a small operating load, reduces energy consumption, improves the transmission efficiency and knitting efficiency, is convenient to maintain and adjust and increases the economic benefits of enterprises. (FIG. 1)
Patent MY-196677-A (MY)
Title: Paint Application and Drying Device and Paint Application and Drying Method
Inventor: SHIRONO HIROSHI
IPC: F26B13/10
Filed: 2017-11-02
Abstract: A paint application and drying device (2) for performing paint application and drying on a steel strip (S) being transported continuously includes: a transport unit (4); a paint application unit (6); an oven (8); an exhaust unit (10); a concentration measurement unit (12); and a controller (14), wherein the controller (14) calculates a predicted reaching concentration (D3) based on the organic solvent concentration (D2) measured by the concentration measurement unit (12), and when the predicted reaching concentration (D3) is equal to or more than a predetermined threshold concentration (D4), performs control to stop paint application by the paint application unit (6) while continuing the transportation of the steel strip (S) by the transport unit (4). (Figure 4C)
Patent MY-193978-A (MY)
Title: A chip packaging box
Inventor: KHOO MAO SHI
IPC: H01L21/673
Filed: 2018-09-28
Abstract: AA chip packaging box, comprising a body (10), grid units (12) provided on the body (10), and a positioning frame (11) extending downwardly around an outer periphery of the body (10); a bottom surface of each of the grid units (12) is provided with intersecting grooves (121); side walls (123) of each of the grid units (12) incline towards a center of the corresponding grid unit (12) from top to bottom. The present invention is used for storage and transportation of chips (20). Identical grid units (12) are provided on the surface of the present invention. Intersecting grooves (121) are provided on the supporting surface that supports a chip (20) at the bottom surface of each grid unit (12), such that the supporting surface of each grid unit (12) does not entirely contact the bottom surface of the corresponding chip (20) placed inside. Therefore, the influences of vacuum adherence and static electricity are reduced, thereby preventing the chip (20) from adhering with its corresponding grid unit (12) due to electrostatic adherence. Hence, the chip (20) is being better protected.
Patent SG-10201806617X-A (SG)
Title: Method for detecting water level of heat transfer tubes and method for inspecting heat transfer tubes
Inventor: TOMOHIRO HARADA
Filed: 2018-08-02
Abstract: METHOD FOR DETECTING WATER LEVEL OF HEAT TRANSFER TUBES AND METHOD FOR INSPECTING HEAT TRANSFER TUBES The present invention provides a method for detecting a water level of a plurality of heat transfer tubes extending downward from a header lying in a horizontal direction. The method includes: a transmission process of continuously transmitting ultrasonic waves upward from an ultrasonic sensor to a lower surface of an inspection nozzle horizontally protruding from the header; a drainage process of performing drainage from the heat transfer tubes and the header; a drainage stoppage process of stopping the drainage at a point in time when a state in which a reflected signal of the ultrasonic waves is detected by the ultrasonic sensor changes to a state in which the reflected signal is not detected due to the drainage; and an opening process of opening at least a part of the inspection nozzle after the stoppage of the drainage. (FIG. A)
Patent SG-10201902166W-A (SG)
Title: Sers sensors
Inventor: WANG YUSONG
Filed: 2019-03-11
Abstract: SERSSENSORS The present disclosure generally relates to a surface-enhanced Raman spectroscopy (SERS) sensor (100) and a method (200) of manufacturing the SERS sensor (100). The SERS sensor (100) comprises a flexible substrate (102) and 3D nanomaterials (104) deposited on the flexible substrate (102) by a printing process, the 3D nanomaterials (104) comprising anisotropic nanostructures (106) formed of a 10 metallic material, wherein each anisotropic nanostructure (106) comprises a plurality of pointed end portions (108) extending from a central core portion (110). Figure 1 15 25
Patent SG-11201805184T-A (SG)
Title: Combination therapy
Inventor: GRIFFITH HUGH
IPC: A61K33/00
Filed: 2016-12-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 11M1111101110101011111 HO 11111 011101011011110111111101110111110111011# International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/109486 Al 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/7068 (2006.01) A61K 33/00 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/GB2016/054018 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: 21 December 2016 (21.12.2016) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: PCT/GB2015/054158 (84) Designated States (unless otherwise indicated, for every 23 December 2015 (23.12.2015) GB 1609770.1 3 June 2016 (03.06.2016) GB kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: NUCANA BIOMED LIMITED [GB/GB]; 10 Lochside Place, Edinburgh Scotland EH12 9RG (GB). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventor: GRIFFITH, Hugh; c/o NuCana BioMed Lim- ited, 10 Lochside Place, Edinburgh EH12 9RG (GB). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (74) Agent: HGF LIMITED (LEEDS); 1 City Walk, Leeds LS11 9DX (GB). Published: — with international search report (Art. 21(3)) Il GC iv 01 0 1-1 IN 1-1 (54) Title: COMBINATION THERAPY 0 N (57) : This invention relates to a combination of gemcitabine-[phenyl-benzoxy-L-alaninyl)]- phosphate (chemical name: 2'- en. ) Deoxy-2',2'-difluoro-D-cytidine-5'-0-[phenyl (benzoxy- L- alaninyl)] phosphate) (NUC-1031) and a platinum-based anticancer agent selected from cisplatin, picoplatin, lipoplatin and triplatin. The combinations are useful in the treatment of cancer and particu - .,. laxly biliary tract and bladder cancer.
Patent SG-11201806943Q-A (SG)
Title: Support cage for a filter element, filter element, and use for such a filter element
Inventor: GROTH PETER
IPC: B01D46/24
Filed: 2017-02-21
Abstract: : SUPPORT CAGE FOR A FILTER ELEMENT, FILTER ELEMENT, AND USE FOR SUCH A FILTER ELEMENT 5 The invention relates to a support retainer for filter element with a base body, which extends along a longitudinal axis from an upper end to a lower end and a retainer wall is formed between the upper and the lower end, and wherein the retainer wall is formed perpendicular to the longitudinal axis in a ring-shaped at least in a cross section, and 10 the retainer wall has a plurality of openings and the retainer wall is at least partially manufactured from a plastic, wherein the openings are rhombus-shaped. Figure 1 15
Patent SG-11201809396S-A (SG)
Title: A specific trifluoroethyl quinoline analogue for use in the treatment of apds
Inventor: ALLEN RODGER ANTHONY
IPC: A61P37/00
Filed: 2017-05-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 November 2017 (23.11.2017) WIPO I PCT omit IIl Hot 0 mu im iflo Hs (10) International Publication Number WO 2017/198590 Al (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/519 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/EP2017/061567 (22) International Filing Date: 15 May 2017 (15.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1608797.5 19 May 2016 (19.05.2016) GB (71) Applicant: UCB BIOPHARMA SPRL [BE/BE]; 60, Al- lee de la Recherche, 1070 Brussels (BE). (72) Inventors: ALLEN, Rodger Anthony; c/o IPD, UCB Cell- tech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). ARMSTRONG, Martin John; c/o IP Department, UCB Biopharma SPRL, 60, Allee de la Recherche, 1070 Brussels (BE). CAVAZZANA, Marina; Institut Imagine - INSERM U1163, Laboratoire de lympho-hematopoiese humaine, 24, Boulevard du Montparnasse, 75015 PARIS (FR). KRACK- ER, Sven; Institut Imagine - INSERM U1163, Laboratoire de lympho-hematopoiese humaine, 24, Boulevard du Mont- parnasse, 75015 Paris (FR). MCHALE, Duncan Philip; c/ o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). PAYNE, Andrew Charles; c/o IPD, UCB Cell- tech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). (74) Agent: UCB INTELLECTUAL PROPERTY; c/o UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1-1 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, O EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 00 1-1 KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) N (54) Title: A SPECIFIC TRIFLUOROETHYL QUINOLINE ANALOGUE FOR USE IN THE TREATMENT OF APDS 0 (57) : N- {(R)-1-[8-Chloro-2-(1-oxypyridin-3-y1)-quinolin-3-y1]-2,2,2-trifluoroethyll -pyrido[3,2-d]pyrimidin-4-ylamine is ef- \" fective in the treatment and/or prevention of activated phosphoinositide 3-kinase delta syndrome (APDS).
Patent IS-2660-B (IS)
Inventor: SCHUCKMANN ALFRED VON
IPC: A61M15/00
Filed: 2000-12-20
Abstract: The invention relates to a device (V) for emptying powder-containing cavities (1) sealed by means of a covering foil (9) by means of a suction tube (11) which can be set by hand and whose leading end is positioned relatively to the cavity (1) and pierces in a guided manner the covering foil (9), leaving a free cross section for air to flow into the cavity (1), and, to achieve a solution which is beneficial for production and reliable in manipulation, proposes that the leading end of the suction tube (11) has, adjacent and axially projecting with respect to cutting edges (12) provided at that point, extensions (22/82) which are guided in slots (19 and/or 83, 55 or 25, respectively) of a carrier (T) adjacent to the cavities (1) in a shape-locked/rotationally fixed manner, in which carrier (T) the cavities (1) can be inserted as blister packs (2).
Patent IS-2328-B (IS)
Inventor: SPADONE THOMAS
IPC: B22D5/00
Filed: 2005-09-14
Abstract: Mold (1) for fabrication of an ingot by cooling and solidification of a mass of molten metal includes a wall (2) and an opening (3). The wall defines a bottom (4) and an inner surface (5) of which a part (S), the cooling surface, is able to evacuate all or part of the thermal energy released by the mass of metal during cooling and solidification. The wall incorporates at least one shaped element (6,7,8) to form at least one locking element, a stacking element or a handling element on the ingot. The cooling surface includes at least one element with a flat surface (Si) forming all or part of the bottom of the mould. At least one point (C) exists on a plane (Pi) tangent to each surface such that all the right segments (D) connect all points (R)of the cooling surface to the point (C) passing uniquely to the inside of the mold and the total area of the element(s) of the surface (Si) is at least equal to 10 % of the cooling surface. An independent claim is also included for the fabrication of a metal ingot using this mold.
Patent AT-406141-B (AT)
Inventor: PESL JOSEF
IPC: F16N7/14
Filed: 1997-03-07
Granted: 2000-02-25
Abstract: An apparatus for cleaning and lubricating drive chains, in particular of motorcycles, include a substantially closed housing formed of two mutually connectable halves providing openings for allowing the drive chain to pass through and includes brushes which are attached in the housing to wipe off the drive chain. An easy and effective cleaning is achieved by using nozzles in the housing which are directed against the drive chain and are in connection with connections on the outside of the housing. The housing also provides with a drainage opening which is arranged for the bleeding off of the media injected into the apparatus.
Patent HU-193591-B (HU)
Title: Process for the production of dihydropyridazinone-derivatives, as well as of pharmaceutical preparations containing these derivatives as agent
Inventor: SLATER ROBERT A
IPC: A61P7/02
Filed: 1985-01-11
Abstract: Compounds of the formula (I): 
<CHEM>
 and pharmaceutically acceptable salts are described, wherein R<1> is hydrogon or methyl and R<2> is hydrogen or C1-4alkyl. These compounds have inotropic, vasodilator, bronchodilating and platelet aggregation inhibiting properties. Pharmaceutical compositions are described as are methods of use. Intermediates and processes for the preparation of the compounds of the formula (I) are described.
Patent HU-208742-B (HU)
Inventor: HORVAI GYOERGY
IPC: G01N27/02
Filed: 1990-01-12
Abstract: A találmány szerinti eljárásban az amperometriás mérőberendezés mérőelektródjaként potenciometriás méréseknél használatos, 0,1-10 tr aktív anyagot, legfeljebb 10 tr ellenálláscsökkentő adalékot, 75-99,9 tr membrán vázanyagot és adott esetben hidrofil filmet is tartalmazó mérőelektródot használnak, ahol az aktív anyag ismerten alkalmazott semleges ionofor vagy töltött vázú ioncserélő; az ellenálláscsökkentő adalék lipofil só, előnyösen fenilborát-származék K, Na vagy ammónium sója; a hidrofil film vízzel jól nedvesíthető vékony fólia, előnyösen cellofán, dialízismembrán, cellulóz fólia, valamint a membrán vázanyag szokásosan alkalmazott lágy, rugalmas polimer vagy lágyított polimer, hidrofób jellegű vagy porózus polimer, előnyösen lágy PVC, szilikongumi, 2-nitrofenil-alkiléterrel átitatott hidrofób porózus membrán. HU 208 742 B A leírás terjedelme: 8 oldal (ezen belül 1 lap ábra)
Patent LT-4157-B (LT)
Title: Pushing unit
Inventor: GRIMMIG DIETER
IPC: B63B35/70
Filed: 1996-08-14
Abstract: A pushing unit with a pusher craft (1) and a lighter (2) pushed and controlled by the pusher craft is designed for use in shallow waters with the optimum cargo-carrying capacity in that the pusher craft (1) is propelled by a paddle-wheel (3) fitted at the stern.
Patent ME-00600-B (ME)
Inventor: MAFFEI PAOLA
IPC: A61K47/38
Filed: 2007-07-31
Abstract: Polioli stabilizuju polimorfui oblik rifaksimina, a naročito β oblik. Kada se polioli koji imaju bar dve hidroksilne grupe dodaju u prah rifaksimina, polimorf β je stabilan i ostaje stabilan tokom vremena nezavisno od vlažnosti okoline. U ovom pronalasku, opisan je postupak za pripremanje formulacija koje se sastoje od stablnih  i čistih  polimorfuih oblika koji su u stanju da daju farmaceutski proizvod. Polioli stabilizuju polimorfui oblik rifaksimina, a naročito β oblik. Kada se polioli koji imaju bar dve hidroksilne grupe dodaju u prah rifaksimina, polimorf β je stabilan i ostaje stabilan tokom vremena nezavisno od vlažnosti okoline. U ovom pronalasku, opisan je postupak za pripremanje formulacija koje se sastoje od stablnih   i čistih   polimorfuih oblika koji su u stanju da daju farmaceutski proizvod.
Patent YU-48498-B (YU)
Inventor: DR DVORNIC PETAR
Filed: 1993-04-07
Abstract: Postupak za dobijanje α,ω-teleheličnih difunkcionalnih oligopolisiloksana opšte formule: R1 R1 X (Si-O-)n Si-X R2 R2 gde R1 i R2 označavaju alkil-(C=1-5), aril-, alkoksi-, fenoksi- ili sličnu grupu ili vodonik, n je ceo broj između 3 i otprilike 1000, a X predstavlja reakciono sposoban atom ili grupu, kao što su, npr. atom vodonika ili halogena, ili hidroksi-, amino-, epoksi-, karboksi-, vinil-ili izocijano-grupa, ili niži alkil-, aril- ili aralkil-grupu koja kao supstituent sadrži X, naznačen time, što ciklosilikosan ili smesa ciklosiloksana i/ili lineami polisiloksan i/ili smesa linearnih polisiloksana i/ili smesa cikličnih i linearnih polisiloksana, reaguje sa difunkcionalnim disiloksanom opšte formule R1 R1 X Si - O - Si - X R2 R2 u kojoj je R1 ima značenje CH3 a R2 označava H ili CH3 i H a X predstavlja vinil-grupu, pri čemu u formuli navedeni supstituenti imaju navedena značenja, prvenstveno sa 0,1 do 5 masenih % disiloksana u odnosu na polisiloksan, u prisustvu katjonske jonoizmenjivačke smole, prvenstveno na bazi umreženog sulfonovanog polistirena, na temperaturi do 120В°C, pri čemu se izborom koncentracija, temperature i vremena trajanja kontroliše prosečna molekulska masa proizvedenog oligo(ko)polimera, što se po uspostavljanju ravnoteže, ili pri željenom stepenu konverzije polaznog materijala, iz reakcione smese prvo udalji katalizator, a zatim i eventualno prisutni ciklosiloksani i što se dobijeni linearni α,ω -telehelični difunkcionalni oligopolisiloksan, po potrebi, prevede u drugi polisiloksan. - Prijava sadrži još 5 zavisnih zahteva.
Patent YU-46315-B (YU)
Title: Postupak za dobijanje nonapeptidnih i dekapeptidnih derivata hormona za oslobadjanje luteinizirajućeg hormona
Inventor: NESTOR J J
IPC: C07C/
Filed: 1987-05-08
Abstract: POSTUPAK ZA DOBIJANJE PEPTIDA opšte formule (I) (piro) Glu-His-V-Ser-Tyr-X-Y-Arg-Z u kojoj V je triptofil, fenilalanil ili 3-(1-naftil)-L-alanil, X je 3 (R)-D-alanil gde R je 2-naftil, 1-naftil, 2-fluorenil, 2,2-difenilmetil, 4-bifenil, 2,4,6-trimetilfenil i 9-antril, Y je L-leucil i N-metil-L-leucil i Z je NHNHC)NH2 i NH-CH2-CO-NH2 ili njihovih farmaceutski prihvatljivih soli, naznačen time, što se vrši kuplovanje deveto-članog peptida (piro)-Glu-His-V-Ser-Tyr-X-Y-Arg-Pro sa amino kiselinskim ostatkom takvim kao što je Aza-Gly-NH2 u pogodnom organskom rastvaraču takvom kao što je dimetilfor-mamid i na temperaturi od -25 do +25В° C u prisustvu N,N -diciklohek-silkarbodiimida 1-hidroksibenzotriazola na pH 7,5 ili sa pdo istim uslovima vrši kuplovanje petočlanih fragmenata (piro)Glu-His-Trp-Ser-Tyr i D-Nal(2)-Leu-Arg-Pro-Gly-NH2 u jprisustvu N,N -dicikloheksilkarbodiimida na pH 8-9, tako da se dobija peptid formule (I) koji se dalje prema potrebi sa kiselinom prevodi u svoju farmaceutski prihvatljivu so.
Patent YU-49047-B (YU)
Title: Novel 2-cyano-3-hydroxy-propenamides, process for their preparation, their use as medicaments and pharmaceutical compositions containing them
Inventor: KUO ELIZABETH ANNE
IPC: A61K31/44
Filed: 1993-12-29
Abstract: The invention relates to the products <IMAGE>  in which     A, B and E represent =CH- or N with A or B or E = N,   R represents cycloalkyl, alkenyl or alkynyl (>/= C6),   R1 represents H or (C1-3)alkyl, R2 and R3 represent H, Hal, CN, NO2, (C1-6)alkyl, -cycloalkyl, -alkoxy or -alkylthio, -(CH2)m-CX3, -O-(CH2)m-CX3, -S-(CH2) m-CX3, -O-(CX2)m-CX3 or -S-(CX2)m-CX3, m being 0 to 3 and X being halogen, or -COR4, R4 being H, alkyl or cycloalkyl (>/= C3)   or R2 and R3 together form -O-CH2-O-,  as well as to their tautomeric forms and to their salts with bases. The products (I) have advantageous anti-inflammatory properties.