Patent SG-11201806581T-A (SG)
Title: Combination products for the treatment of rsv
Inventor: YSEBAERT NINA
IPC: A61P31/12
Filed: 2017-02-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011111111101111011001111101111011111 International Bureau 0.. .... .. ..... ..or::,„, (10) International Publication Number (43) International Publication Date WO 2017/134133 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/437 (2006.01) A61K 31/53 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/7056 (2006.01) A61K 31/5377 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61P 31/12 (2006.01) A61K 31/55 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 39/395 (2006.01) A61K 31/5513 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 31/41 (2006.01) A61K 31/70 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, A61K 31/4184 (2006.01) A61K 31/519 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, A61K 31/52 (2006.01) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (21) International Application Number: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, PCT/EP2017/052201 TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: ZA, ZM, ZW. 2 February 2017 (02.02.2017) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 16154035.6 3 February 2016 (03.02.2016) EP DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: JANSSEN SCIENCES IRELAND UC SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [IE/IE]; Eastgate Village, Eastgate Little Island, Co Cork GW, KM, ML, MR, NE, SN, TD, TG). (E). — Declarations under Rule 4.17: (72) Inventors: YSEBAERT, Nina; c/o Janssen Pharmaceutica — as to applicant's entitlement to apply for and be granted a _ NV, Turnhoutseweg 30, 2340 Beerse (BE). 4.17(u)) . GOEYVAERTS, Nele Isa E.; Janssen Pharmaceutica patent (Rule c/o NV, Turnhoutseweg 30, 2340 Beerse ROYMANS, Published: (BE). Dirk Andre E.; c/o Janssen Pharmaceutica NV, Turnhout- - with international search report (Art. 21(3)) seweg 30, 2340 Beerse (BE). KOUL, Anil; c/o Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse (BE). — before the expiration of the time limit for amending the = claims and to be republished in the event of receipt of — _ (74) Agent: VERBERCKMOES, Filip; J&J Patent Law De- 48.2(h)) amendments (Rule partment, Turnhoutseweg 30, 2340 Beerse (BE). M = = = = = = = (54) Title: COMBINATION PRODUCTS FOR THE TREATMENT OF RSV ,-1 (57) : The present invention is directed to the combination of the RSV inhibiting Compound A, 3-({5-chloro-1 43- i.e. ..! (methylsulfonyl)propy1]-1 11-indo1-2-yllmethyl)-1 -(2,2,2-trifluoroethyl) 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and one or more RSV inhibiting Compound B selected from from ribavirin, GS-5806, MDT-637, BTA-9881, BMS-433771, YM-543403, A- M en 60444, TMC-353121, RFI-641, CL-387626, MBX-300, AZ-27, MEDI8897, CR9501, palivizumab, 3-({5-chloro-1 43-(methylsulf- onyl)propy11- 1 11-benzimidazol-2-y1 1 methyl)-1 cyclopropyl- 1,3-dihydro -2H-imidazo [4,5-c]pyridin-2-one, 3-[[7-chloro-3-(2 ethyl - 71' sulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methy1]-1 -cyclopropyl-imidazo[4,5-c]pyridin-2 one, N-(2-fluoro-6-methylpheny1)-6-(4-(5- en methyl-2-(7-oxa-2-azaspiro [3 .5]nonan-2 yOnicotinamido)benzoy1)-5,6-dihydro-4H-benzo [b]thieno [2,3- d]azepine-2-carboxamide, 1-1 ---- and 4-amino-8434[2-(3,4-dimethoxyphenypethyl]aminotropyl]-6,6-dimethyl-2-(4-methyl 3-nitropheny1)-3H-imidazo[4,5- IN h]isoquinoline-7,9(6H,8H)-dione, for treating or ameliorating RSV infection. The invention further relates to the combination C product of Compound A and one or more Compound B, a pharmaceutical product comprising Compound A and one or more Com - N pound B, the use of the combination of Compound A and one or more of Compound B - or the pharmaceutical product comprising O CompoundA and one or more Compound B - for the treatment of RSV infection, and a method of treating or ameliorating RSV in- fection in a subject in need thereof comprising administering the combination of Compound A and one or more Compound B in an effective amount to said subject.