baber/WOPTO huggingface dataset:
Patent CY-1111636-T1 (CY)
Inventor: ERTL PETER FRANZ
IPC: C12N15/89
Filed: 2011-06-29
Abstract: Use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide; and an HIV gp120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV, wherein the protein or polynucleotide is delivered via a bombardment approach.
Patent CY-1112638-T1 (CY)
Title: Χρηση των παραγωγων ινδολιου ως ενεργοποιητες νurr-1 για την θεραπεια νοσου ραrκινsον
Inventor: BOUBIA BENAÏSSA
IPC: C07D209/18
Filed: 2012-03-14
Abstract: Η παρούσα εφεύρεση αφορά μια λαμβανόμενη από ινδόλιο ένωση, ιδιαίτερα χρήσιμη στη θεραπεία και που χαρακτηρίζεται από το ότι η ένωση επιλέγεται μεταξύ iii) των ενώσεων του τύπου (Ι), όπου: το R1 είναι ένα άτομο αλογόνου ή τριφθορομεθυλο ομάδα, το R2 είναι ένα άτομο υδρογόνου ή (C1-C4) αλκυλ ομάδα, το R3 είναι ένα ισοπροπύλ(1-μεθυλαιθυλ) ομάδα ή τ- βουτυλ-(1,1-διμεθυλοαιθυλ) και n= 3 ή 4. Η εφεύρεση αφορά περαιτέρω τα φαρμακευτικώς αποδεκτά άλατα των εν λόγω ενώσεων του τύπου (Ι). Η εφεύρεση μπορεί να χρησιμοποιηθεί για τη θεραπεία των νευροεκφυλιστικών νόσων και ιδίως της νόσου του Parkinson.
Patent CY-1115264-T1 (CY)
Title: Μεθοδοι παραγωγης κυτταρων ή οργανισμων με αναστολη εκφρασης καποιου γονιδιου (knockdown) χρησιμοποιωντας ειδικους ως προς την rna ακολουθια μεσολαβητες της παρεμβολης rna και εφαρμογες αυτων
Inventor: TUSCHL THOMAS
IPC: C12N15/113
Filed: 2014-05-30
Abstract: Η παρούσα εφεύρεση αφορά κάποιο in vitro σύστημα δροσόφιλας (Drosophila) το οποίο χρησιμοποιήθηκε για να αποδειχθεί ότι dsRNA έχει μετατραπεί σε τμήματα RNA μήκους 21-23 νουκλεοτιδίων (nt). Επιπλέον, όταν τα συγκεκριμένα θραύσματα 21-23 nt καθαριστούν και προστεθούν πάλι στα εκχυλίσματα της δροσόφιλας, διαμεσολαβούν στην παρεμβολή RNA απουσία του μακριού dsRNA. Συνεπώς, τα συγκεκριμένα θραύσματα των 21-23 nt είναι ειδικοί ως προς την ακολουθία, μεσολαβητές της αποικοδόμησης RNA. Στα συγκεκριμένα θραύσματα των 21 -23 nt πρέπει να υπάρχει κάποιο μοριακό σήμα, το οποίο μπορεί να είναι το συγκεκριμένο μήκος των θραυσμάτων, τα οποία προσελκύουν τους κυτταρικούς παράγοντες που συμμετέχουν στην RNAi. Η παρούσα εφεύρεση περιλαμβάνει τα συγκεκριμένα θραύσματα των 21-23 nt και τη χρήση τους για την ειδική αδρανοποίηση της γονιδιακής λειτουργίας. Η χρήση αυτών των θραυσμάτων (ή χημικώς συντιθέμενων ολιγονουκλεοτιδίων ίδιας ή παρόμοιας φύσης) επιτρέπει τη στόχευση των ειδικών mRNA που προορίζονται για να αποικοδομηθούν σε κύτταρα θηλαστικών, όπου η χρήση μακρών dsRNA για την έκλυση RNAi συνήθως δεν είναι πρακτική, πιθανόν λόγω των επιβλαβών επιδράσεων της απαίτησης της ιντερφερόνης. Αυτή η ειδική στόχευση κάποιας συγκεκριμένης γονιδιακής λειτουργίας είναι χρήσιμη σε θεραπευτικές εφαρμογές και των λειτουργιών του γονιδιώματος.
Patent CY-1122677-T1 (CY)
Title: Καινοτομος ανοσοθεραπεια εναντι ορισμενων ογκων συμπεριλαμβανομενων ογκων των νευρωνων και του εγκεφαλου
Inventor: SCHOOR OLIVER
IPC: A61K38/16
Filed: 2020-01-28
Abstract: Η παρούσα εφεύρεση σχετίζεται με πεπτίδια, νουκλεϊκά οξέα και κύτταρα για χρήση σε ανοσοθεραπευτικές μεθόδους. Συγκεκριμένα, η παρούσα εφεύρεση σχετίζεται με την ανοσοθεραπεία του καρκίνου. Η παρούσα εφεύρεση σχετίζεται επιπλέον με όγκο-σχετιζόμενους πεπτιδικούς επιτόπους κυτταροτοξικών Τ-κυττάρων (cytotoxic Τ lymphocytes - CΤL), μεμονωμένους ή σε συνδυασμό με άλλα ογκο-σχετιζόμενα πεπτίδια, οι οποίοι λειτουργούν ως ενεργά φαρμακευτικά συστατικά συνθέσεων εμβολίων που διεγείρουν αντικαρκινικές ανοσοαπαντήσεις. Η παρούσα εφεύρεση σχετίζεται με 30 πεπτιδικές αλληλουχίες και τις παραλλαγές τους που προέρχεται από μόρια ΗLΑ τάξης Ι και II ανθρώπινων καρκινικών κυττάρων που μπορούν να χρησιμοποιηθούν σε συνθέσεις εμβολίων για να επιφέρουν αντικαρκινικές ανοσοαπαντήσεις.
Patent CY-1124742-T1 (CY)
Title: 4'-φθορο-νουκλεοσιδια, 4'-φθορο-νουκλοεοτιδια και αναλογα αυτων για τη θεραπευτικη αγωγη toy hcv
Inventor: BEIGELMAN LEONID
IPC: C07H19/067
Filed: 2021-05-12
Abstract: Στο παρόν αποκαλύπτονται νουκλεοτιδικά ανάλογα, μέθοδοι σύνθεσης νουκλεοτιδικών αναλόγων και μέθοδοι θεραπευτικής αγωγής ασθενειών ή/και καταστάσεων όπως λοίμωξης HCV με ένα ή περισσότερα νουκλεοτιδικά ανάλογα.
Patent GR-900300140-T1 (GR)
Title: Derivative of a tissue plasminogen activator
Inventor: STERN ANNE
IPC: C07K14/745
Filed: 1991-09-27
Abstract: PCT No. PCT/EP90/00194 Sec. 371 Date Sep. 28, 1990 Sec. 102(e) Date Sep. 28, 1990 PCT Filed Feb. 6, 1990 PCT Pub. No. WO90/09437 PCT Pub. Date Aug. 23, 1990.A new thrombolytically active protein is not glycosylated and consists of the following amino acid sequence: 1SYQGNSDCYFGNGSAYRGTHSLTESGASCL   PWNSMILIGKVYTAQNPSAQ 51ALGLGKHNYCRNPDGDAKPWCHVLKNRRLT   WEYCDVPSCSTCGLRQYSQP 101QFRIKGGLFADIASHPWQAAIFAKHRRSPG   ERFLCGGILISSCWILSAAH 151CFQERFPPHHLTVILGRTYRVVPGEEEQKF   EVEKYIVHKEFDDDTYDNDI 201ALLQLKSDSSRCAQESSVVRTVCLPPADLQ   LPDWTECELSGYGKHEALSP 251FYSERLKEAHVRLYPSSRCTSQHLLNRTVT   DNMLCAGDTRSGGPQANLHD 301ACQGDSGGPLVCLNDGRMTLVGIISWGLGC   GQKDVPGVYTKVTNYLDWIR   351DNMRP or said amino acid sequence with an additional N-terminal methionine. DNA sequences encoding the thrombolytically active, non-glycosylated protein and pharmaceutical compositions containing said protein are also disclosed. The protein possesses particularly favorable properties when used to dissolve blood clots.
Patent GR-900300174-T1 (GR)
Title: An adjustable bolt for sash locks such as on sliding door and window sashes
Inventor: CATTANEO MARIO
IPC: E05B63/06
Filed: 1991-09-27
Abstract: An adjustable bolt for locks of sliding sashes consisting of a hook-shaped portion (11) provided with a tubular element (13) fitting slidably over a second solid element (14) connected to the mechanism of a lock, in turn mounted to the moving part of the sash. A screw-type locking means (16) is inserted between the tubular element (13) and the second solid element (14). By adjusting the tubular element (13) for position on the solid element (14), precise engagement of the hook (11) with a respective ledge (12) can be achieved, and hence a correctly closing sash.
Patent SI-2962690-T1 (SI)
Title: (+)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl)-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
Inventor: SCHAFER PETER H
IPC: C07D209/00
Filed: 2003-03-20
Abstract: Discussed is stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, or a pharmaceutically acceptable polymorph, salt, solvate or hydrate thereof, as well as a pharmaceutical composition or single unit dosage form comprising such compound and such compound for use as a medicine.
Patent SI-1653365-T1 (SI)
Title: Invalidating storage, clearing buffer entries
Inventor: SLEGEL TIMOTHY
IPC: G06F12/08
Filed: 2004-05-06
Abstract: A method for invalidating translation table entries and clearing corresponding dynamic address translation (DAT) table entries of a translation lookaside buffer (TLB) associated with a processing unit in a computer system, the computer system comprising one or more address translation tables providing translation information to translate virtual addresses to real addresses, wherein address translation table entry information is maintained in the TLB, the method comprising: a) fetching for execution a multifunction Invalidate DAT Table Entry (IDTE) machine instruction, the IDTE instruction comprising an opcode field identifying said instruction and an information field comprising: 1) a first register field for identifying a first register for indicating an origin and type of an address translation table containing a range of one or more entries to be invalidated, 2) a second register field for identifying a second register for including indices used to select a translation table entry in a type of address translation table indicated by the first register, and an option bit for indicating whether a clear by address space control element (ASCE) operation or an invalidating-and-clearing operation is to be performed, and a range field for identifying a number of additional translation table entries, in the address translation table indicated by the first register, to be invalidated, and 3) a third register field for identifying a third register for indicating an origin and type of address translation table to be used when the clear by address space control element operation is to be performed for only selectively clearing TLB entries; and b) executing the fetched IDTE machine instruction, the executing step comprising: 
i. determining, from the option bit in the second register, whether a clear by address space control element operation is to be performed; 
ii. responsive to the option bit indicating that the clear by address space control element operation is to be performed, clearing the TLB, independent of the content of the first register, of those entries in which the address translation table origin of a translation table was used to create the entries in the TLB corresponds to the address translation table origin in the third register; 
iii. responsive to the option bit indicating that the clear by address space control element operation is not to be performed, invalidating the range of address translation table entries of a translation table identified by the range field, and clearing the TLB entries corresponding to the invalidated entries.
Patent SI-1904998-T1 (SI)
Title: Electronic circuit and method for dynamic piloting of light sources in variable message information panels
Inventor: IVALDI STEFANO AESYS S P A
IPC: G09G3/32
Filed: 2006-07-13
Abstract: The invention concerns an electronic circuit for dynamic command of light sources in variable message information panels. It includes a number of elementary circuits consecutively connected between them, each having at least one LED connected through respective switchable branches, to a feed voltage, to a LED short-circuiting line, to a contiguous elementary circuit and to a component or a control circuit output. Thus, by commanding the switching elements through the control circuit several elementary circuits can be selectively configured as closed circuits, each of which having a chain of LEDs activated in dynamically variable numbers wherein the feed voltage is applied to the feed branch of the first active LED of the chain and the control circuit output is closed on the last active LED of the activated LEDs chain.
Patent TR-200003592-T1 (TR)
Title: Radyasyonla işlenmiş kapsülleme malzemesi içeren optik fiber şeritleri.
Inventor: WILSON DANIEL A
IPC: G02B6/44
Filed: 2000-03-27
Abstract: Optik fiber seritler, radyasyonla islenmis kapsülleme malzemesi içinde kapsüllenmis en az iki optik fiber alt birim seridinden olusur. Rasyasyonla islenmis kapsülleme malzemesi, alt birim seritlerinin, kapsülleme malzemesi elle yirtilarak ayrilmalarini saglar ve optik fiber seridin bükülmesiyle alt birim seritlerine yapisir. Radyasyonla islenmis kapsülleme malzemesi tercihen yaklasik 2.20 pound kuvvetin altinda bir yirtilma direncine ve yaklasik 0.0044 pound kuvvetin üzerinde bir alttaki yüzeye yapisma kuvvetine sahiptir.
Patent DE-3587548-T2 (DE)
Inventor: HERRERA-ESTRELLA LUIS
IPC: C12N15/29
Filed: 1985-12-20
Granted: 1993-12-23
Abstract: The invention relates to chimaeric genes which encode a fusion protein consisting of a transit peptide of a chloroplast protein-precursor, linked directly or indirectly to another protein. It also relates to recombinant vectors containing said chimeric genes suitable for the transformation of plant cells, whereby said another protein can be translocated and processed in the chloroplats.
Patent DE-3850453-T2 (DE)
Inventor: WOZNIAK DON STEVEN
IPC: C08L27/06
Filed: 1988-07-21
Granted: 1994-11-03
Abstract: Disclosed is an anti-stat which is effective in polyvinyl chloride polymeric parts to dissipate charge phenomena occurring at a surface thereof. The anti-stat comprises an ethoxylated fat-forming alcohol and a dibasic acid-capped fat-forming alcohol which is incorporated in an effective amount in the polyvinyl chloride polymeric material.
Patent DE-3851621-T2 (DE)
Inventor: MIYASHITA EIJI - -
IPC: A61F7/02
Filed: 1988-05-06
Granted: 1995-02-09
Abstract: A hot compress structure is produced by sealing a heat generating compsn. which generates heat in the presence of air into a flat bag-like member whose one side is made of a gas-permeable film and which has no open portion. A wet compress layer is disposed on the other surface of the flat bag-like member. The moisture permeability of the gas-permeable film according to an ASTM method (E-96-80D) is limited to 100-400 g/m2.24 hrs. so that when the structure is put on the human body in close contact, mild heat of the heat generating compsn. can be transmitted uniformly to the entire surface of the skin through the wet compress layer. Keeps a safe temp. at which no low temp. burn occurs for a long period, and moreover promotes local blood circulation and improves local metabolism.
Patent DE-3879031-T2 (DE)
Inventor: NIJS HENDRIK DE
IPC: A61K9/22
Filed: 1988-07-07
Granted: 1993-06-24
Abstract: The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally.
Patent DE-3880404-T2 (DE)
Inventor: SAKAKIBARA SHIGERU
IPC: G05D23/13
Filed: 1988-08-26
Granted: 1993-08-05
Abstract: The control apparatus for water temperature and water flow rate according to the present invention comprises: a mixing valve adapted to be supplied with hot water and cold water, a flow rate controller means disposed to a system for delivering the mixed water from the mixing valve to a place where it is required, and a controller for operating the mixing valve and the flow rate controller means, wherein  said controller comprises  a switch for discharging water and stopping the discharge of water, a setter for the water flow rate and the water temperature of the mixed water, a standard value memory for storing the standard water temperature and the standard water flow rate of the mixed water, a selected value memory for storing the water temperature and the water flow rate selected by the setter and a timer started upon water stopping operation of the switch.
Patent DE-3887922-T2 (DE)
Inventor: MCLUCKEY SCOTT A
IPC: G01N33/00
Filed: 1988-05-26
Granted: 1994-05-26
Abstract: An atmospheric sampling glow discharge ionization source that can be used in combination with an analytical instrument which operates at high vacuum, such as a mass spectrometer. The atmospheric sampling glow discharge ionization source comprises a chamber with at least one pair of electrodes disposed therein, an inlet for a gaseous sample to be analyzed and an outlet communicating with an analyzer which operates at subatmospheric pressure. The ionization chamber is maintained at a pressure below atmospheric pressure, and a voltage difference is applied across the electrodes to induce a glow discharge between the electrodes, so that molecules passing through the inlet are ionized by the glow discharge and directed into the analyzer. The ionization source accepts the sample under atmospheric pressure conditions and processes it directly into the high vacuum instrument, bridging the pressure gap and drawing off unwanted atmospheric gases. The invention also includes a method for analyzing a gaseous sample using the glow discharge ionization source described above.
Patent TR-199801622-T2 (TR)
Inventor: SHAWVER SUSAN E
IPC: D04H13/00
Filed: 1997-02-04
Abstract: Dokunmamis bir elyaf ag tabakasindan olusan, bu agin en az 4 mbar hidrohed'e, 68 gsm'den az baz agirliga sahip oldugu, ve elastik bir poliolefinden mamul tam elastik, hava geçiren bariyer dokuma. Bu dokuma bir laminat ise, SMS, SBL veya NBL laminat olabilir. Bu dokuma özellikle çocuk bezi, inkontinens ürünleri kadin hijyen ürünleri ve enfeksiyon kontrol ürünleri gibi kisisel bakim ürünleri için toplama kanadi olarak kullanilmaya çok uygundur. Bu dokuma ayrica kisisel bakim ürünlerinde astar olarak da kullanilabilir
Patent TR-199801973-T2 (TR)
Inventor: KAO CHE I
IPC: C08F210/16
Filed: 1997-04-01
Abstract: A solution polymerization system for polymerizing an olefin monomer by reacting the monomer with catalyst and solvent has been invented. The system in one aspect includes a flow loop with a product polymer outlet, the flow loop forming a recycling reactor, a cataylst inlet on the flow loop through which catalyst and solvent flow into the flow loop, a monomer inlet on the flow loop through which monomer and solvent flow into the flow loop and, with the catalyst, form a reactant material stream, a first heat exchanger on the flow loop for receiving the reactant materials stream and any formed polymer and for removing heat of reaction or polymerization from the flow loop, and pump apparatus for pumping the reactant materials stream and formed polymer in the flow loop and from the first heat exchanger to the product polymer outlet. In one aspect, the system includes at least one additional heat exchanger on the flow loop for receiving the reactant materials stream and formed polymer and for removing heat of reaction or polymerization from the flow loop, the pump apparatus pumping formed polymer and remaining reactant materials to the product polymer outlet, and a portion of the formed polymer and remaining reactant materials flowing out from the product polymer outlet and the remainder recycling through the flow loop. In one aspect systems and methods according to the present invention are used to make polyethylene.
Patent TR-199802194-T2 (TR)
Inventor: BERBNER HEINZ
IPC: A41D31/00
Filed: 1997-04-30
Abstract: The present invention relates to flameproof fabrics based on melarnine resin fibres, fireproof blankets and clothing made therewith and their use for extinguishing fires and protecting people and objects from fire, combustion products and/or extinguishing agents.
Patent DE-60003025-T2 (DE)
Inventor: WEXLER R
IPC: C07D417/12
Filed: 2000-03-30
Granted: 2004-03-18
Abstract: The present application describes aryl sulfonyls of formula I:or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.
Patent DE-60003794-T2 (DE)
Inventor: YAMAZAKI TAKAYUKI
IPC: C07H15/06
Filed: 2000-02-21
Granted: 2004-06-17
Abstract: Novel sulforhamnosylacylglycerol derivatives represented by General Formula (1): <CHEM> where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid. The derivatives represented by General formula (1) are useful as a DNA polymerase inhibitor and an anticancer agent.
Patent DE-60013204-T2 (DE)
Inventor: GUEVEL JEAN
IPC: D04H1/4242
Filed: 2000-05-19
Granted: 2004-12-30
Abstract: Unidirectional webs of discontinuous carbon fibres having a distribution of length such that the average length of the fibres, i.e. the average length of 50 % of the fibres of a sample is between about 40 and 70 % of the length of the longest fibre in the sample, the fibres being assembled with a resin or an adhesive with a fugitive nature. Unidirectional web of carbon fibres in which the carbon fibres are discontinuous, have a distribution of length such that the average length of the fibres, i.e. the average length of 50 % of the fibres in a sample, is 40-70 % of the length of the longest fibre in the sample, and the fibres are assembled using a resin or an adhesive with a fugitive nature.
Patent DE-60022224-T2 (DE)
Inventor: BULLA JR
IPC: A01N63/50
Filed: 2000-10-25
Granted: 2006-02-16
Abstract: A composition and method for killing fire ants is disclosed that includes the purified and activated Cry toxin from a novel strain of Bacillus thuringiensis, wherein the water soluble, partially purified, activated toxin is provided along with an attractant to kill the imported fire ant using a biodegradable, environmentally sound glycoprotein without a need for toxic chemicals.
Patent DE-60024836-T2 (DE)
Inventor: WIERINGA PIETER
IPC: A61B1/00
Filed: 2000-08-30
Granted: 2006-09-14
Abstract: Imaging apparatus for representing an image of concentration ratios between a first and a second substance in a region of interest of an object, with different measuring values being represented with different colors and/or gray shades. The apparatus comprises a light source capable of irradiating the object with light, which light comprises at least three wavelengths lambda1, lambda2 and lambda3, lambda3 being an isobestic wavelength, lambda1 being a wavelength at which the first substance has a lower absorption than the second substance, and lambda2 being a wavelength at which the first substance has a higher absorption than the second substance. The apparatus further comprises detection means comprising a matrix of pixel detectors, for representing a virtually instantaneous image of the region of interest.
Patent DE-60025709-T2 (DE)
Inventor: BJOERN GOERAN
IPC: A61C8/00
Filed: 2000-02-23
Granted: 2006-08-24
Abstract: A self-tapping implant for use in a jawbone includes a body with plural thread spirals arranged thereon; a conically tapering portion arranged at a front end of the body and having one or more bone-chip recesses therein which accommodate bone material cut off during a tapping operation. The bone-chip recesses are formed by removal of material from the plural thread spirals and body. At least in the conically tapering portion, the plural thread spirals are materially reduced, and each of the materially reduced threads have a cutting edge which extends inward from an outer edge of a respective remaining thread part. Each cutting edge of a number of associated cutting edges of the materially reduced threads have a pointed shape which, in a cross section thereof, essentially follows a line which deviates from a first radius through a point of the pointed shape of the respective remaining thread part.
Patent DE-60025745-T2 (DE)
Inventor: BESSE LAURENT
IPC: G04B33/10
Filed: 2000-11-01
Granted: 2006-11-09
Abstract: The watch mechanism provides a cage and bearing structure providing simple construction of the seconds wheel. The mechanical watch movement comprises a cage provided with bearings and a mean wheel, and a second wheel at the centre of the escapement which pivots in the bearings in axes perpendicular to the plane of the cage. The cage comprises a first pair of bearings defining a first de-centred complementary pivot axis (E). This is placed such that the axis of the mean wheel (A) is at equal distances from this pivot axis and from the axis of the second wheel centred at (C). A second pair of bearing define a second de-centred complementary pivot axis (F), placed such that the axis of the escapement wheel (D) is at equal distances from the pivot axis and from the axis of the second wheel at the centre (C).
Patent DE-60027999-T2 (DE)
Inventor: VONESH J
IPC: A61F2/06
Filed: 2000-01-21
Granted: 2007-04-26
Abstract: The present invention is an improved endovascular device particularly useful for use in transjugular intrahepatic portosystemic shunt (TIPS) procedures. The device employs a two-part stent-graft construction that provides a low permeability membrane to line the shunt and an uncovered stent portion designed to reside in the portal vein. The device provides numerous benefits over previous stents and stent-grafts used in TIPS procedures, including being more compact to deliver, being easier to accurately deploy, a controlled compacted surface with tucked apices, an improved stent winding pattern, and being more flexible in delivery and use.