Patent SG-11201909932Y-A (SG)
Title: Pharmaceutical agents, compositions, and methods relating thereto
Inventor: LAN ZI-JIAN
IPC: A61K31/7076
Filed: 2018-05-01
Abstract: adenosine} miM1158 12',V- Dideoxyodenol4m8 -4,360 (V- Deoxyadeosine) -0-#81 (3Q22,536) -11-#82 (Adenine) -0-*63 (NAD) (SAM) -•-#68 (Sulfur amain of 043) 22 2.2 1.3 1.0 1.4 0.8 0..4 0.0 443 -1,4CDE --C -0-40 -0-8E -4-489 -0-370 2 * NIP Compound COMantreion (FM) \"4\" why 4 Compound concentration (pfd) .0 ID \"t• Fig. 1 2.0 1.8 4.8 0.3 0.4 0.2 0.0 c M © cr (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 November 2018 (22.11.2018) WIPO I PCT Hu omit VIII °nolo III 0111 VIII Oil u moilowo oimIE (10) International Publication Number WO 2018/212980 Al (51) International Patent Classification: A61K 31/7076 (2006.01) (21) International Application Number: PCT/US2018/030371 (22) International Filing Date: 01 May 2018 (01.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/508,730 19 May 2017 (19.05.2017) US (71) Applicant: ALLTECH, INC. [US/US]; 3031 Catnip Hill Road, Nicholasville, KY 40356 (US). (72) Inventors: LAN, Zi-Jian; c/o Alltech, Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356 (US). POWER, Ro- nan; c/o Alltech, Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356 (US). YIANNIKOURIS, Alexandros; c/o All- tech, Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356 (US). YERRAMREDDY, Thirupathi, Reddy; c/o All- tech, Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356 (US). (74) Agent: JARRELL, Brenda, Herschbach et al.; Choate, Hall & Stewart LLP, Two International Place, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: PHARMACEUTICAL AGENTS, COMPOSITIONS, AND METHODS RELATING THERETO 1-1 (57) : The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided C compound and composition. [Continued on next page] WO 2018/212980 Al MIDEDIMOMMIDIREIEHIHOHOHHEIHMEMOIMIE Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3))