Patent SG-11201809531S-A (SG)
Title: BINDING MOLECULES SPECIFIC FOR FCγGAMMA RIIA AND USES THEREOF
Inventor: VOUSDEN KATHERINE
IPC: C07K16/28
Filed: 2017-04-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#111111101110101011111010111110111 Organization 0 01111111111111111111110111011111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\" WO 2017/186908 Al 02 November 2017 (02.11.2017) W I PO I PCT (51) International Patent Classification: (74) Agent: TTOFI, Evangelia; Milstein Building Granta Park, CO7K 16/28 (2006.01) A61P 37/00 (2006.01) Cambridge Cambridgeshire CB21 6GH (GB). A61K 39/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2017/060188 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 28 April 2017 (28.04.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (26) Publication Language: English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (30) Priority Data: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 62/329,627 29 April 2016 (29.04.2016) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/349,804 14 June 2016 (14.06.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: MEDIMMUNE LIMITED [GB/GB]; Mil- kind of regional protection available): ARIPO (BW, GH, stein Building Granta Park, Cambridge Cambridgeshire GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CB21 6GH (GB). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — (72) Inventors: VOUSDEN, Katherine, Ann; Milstein Build EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, ing Granta Park, Cambridge Cambridgeshire CB21 6GH MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (GB). CHEN, Bo; One MedImmuine Way, Gaithersburg, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — = Maryland 20878 (US). SIMS, Gary, Patrick; One Medlm- KM, ML, MR, NE, SN, TD, TG). mune Way, Gaithersburg, Maryland 20878 (US). = Title: BINDING MOLECULES SPECIFIC FOR FCyGAMMA RIIA AND USES THEREOF (54) Figure 1 (57) : The disclosure provides FcyRIIA-binding molecules, for example, human- ized monoclonal antibodies capable of inhibiting FcyRIIA activity, and methods of using ::=7 ; °'\"':',:;:'7„;!:=' `'\"`' - \"1'i: . the FcyRIIA binding molecules, for example, in treating or preventing inflammatory, im- ''' -r -.-\"-\"--\"'\"' s '''''''\"' I ' '' ' ' ' I r '' \" ' mune-mediated, or autoimmune diseases or disorders. = = = = = mr-, . = CCATSGAMG,SSTGCSGCSGCMGCSSCTGCAGACAGSCILMCSGC.C7 =CC.. UC , AG.= rse ,GIG GtITTCMC SC T,GAG: CA= 'M.. © 7 GC Tars.. ^ Il © ei C [Continued on next page] WO 2017/186908 Al MIDEDIMOMMIDIRMEMOMMEIRIMOIMMENEVOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))