baber/WOPTO huggingface dataset:
Patent WO-2021163499-A1 (WO)
Inventor: PU WILLIAM
IPC: A61K38/45
Filed: 2021-02-12
Abstract: Selon certains aspects, l'invention concerne des compositions et des procédés de traitement du syndrome de Barth (BTHS) à l'aide d'une thérapie du gène de la tafazzine humaine ou d'une thérapie de remplacement d'enzyme. Selon certains aspects, la présente divulgation concerne des compositions et des procédés (par exemple, une thérapie génique ou une thérapie de remplacement d'enzyme) pour traiter le syndrome de Barth (BTHS). Il a été ici démontré que certains isoformes de la tafazzine humaine (hTAZ) et la forme entière de la protéine, ainsi que des acides nucléiques codant pour ceux-ci, sont efficaces dans le traitement du BTHS.
Patent WO-2021183849-A1 (WO)
Inventor: NAKAMURA GERALD
IPC: C07K16/24
Filed: 2021-03-12
Abstract: L'invention concerne des anticorps anti-interleukine-33 (IL-33) et des procédés de fabrication et d'utilisation de ceux-ci, par exemple, pour le traitement de troubles médiés par IL-33 (par exemple, des troubles oculaires tels que la DMLA (par exemple, l'atrophie géographique (AG)).
Patent WO-2021216420-A1 (WO)
Title: Méthodes de diminution de l'atrophie musculaire et/ou de promotion de la régénération musculaire
Inventor: LÓPEZ PEDROSA JOSÉ MARÍA
IPC: A23L33/19
Filed: 2021-04-19
Abstract: Des méthodes de diminution de l'atrophie musculaire et/ou de promotion de la régénération musculaire chez un sujet présentant un risque d'atrophie musculaire qui consistent à administrer par voie orale une composition nutritionnelle comprenant au moins un élément parmi une protéine, une matière grasse et un glucide, et des exosomes isolés à partir de lait de bovin comprenant des exosomes intacts. Dans des modes de réalisation spécifiques, le sujet souffre de malnutrition, du syndrome d'immunodéficience acquise (SIDA), du cancer, du diabète, d'une broncho-pneumopathie chronique obstructive (BPCO), d'une sclérose latérale amyotrophique (SLA), d'une stéato-hépatopathie non alcoolique (NAFLD), ou d'une lésion liée à une brûlure, ou a subi un traitement clinique par des corticostéroïdes.
Patent WO-2021225980-A1 (WO)
Title: Methods and systems for determination of an effective therapeutic regimen and drug discovery
Inventor: SOWADSKI JANUSZ
IPC: C12N9/10
Filed: 2021-05-03
Abstract: The present invention relates to the discovery of a method for identifying a treatment regimen for a patient diagnosed with cancer, predicting patient resistance to therapeutic agents and identifying new therapeutic agents, obtaining the specificity profile of a therapeutic agent, a method of designing a scaffold of a therapeutic agent directed against a drug-resistant target, drug scaffolds, and methods of uses thereof to identify drugs to treat diseases such as cancer. Specifically, the present invention relates to the use of an algorithm to identify a mutation in a kinase, determine if the mutation is an activation or resistance mutation and then to suggest an appropriate therapeutic regimen. The invention also relates to the use of a pattern matching algorithm and a crystal structure library to predict the functionality of a gene mutation, predict the specificity of small molecule kinase inhibitors and for the identification of new therapeutic agents.
Patent WO-2021226213-A1 (WO)
Title: Book with resilient element
Inventor: MADDRELL RICHARD
IPC: A61J17/00
Filed: 2021-05-05
Abstract: A book having a chewable element or a portion that can be used as a teether or a teething element, for example, for child to get dental stimulation when the child inserts the book or a part of the book into a mouth. The book includes a plurality of pages and a spine positioned along edge portions of the pages. The edge portions of the pages can be secured directly or indirectly to the chewable element or the portion. The chewable element can have a bore to accommodate a ring. A second or another chewable element can be secured or positioned at a distance from the first chewable element.
Patent WO-2021226282-A1 (WO)
Title: Convolution-based camera and display calibration
Inventor: SOURS MICHAEL ALEXANDER
IPC: G06T11/00
Filed: 2021-05-05
Abstract: Techniques for calibrating cameras and displays are disclosed. An image of a target is captured using a camera. The target includes a tessellation having a repeated structure of tiles. The target further includes unique patterns superimposed onto the tessellation. Matrices are formed based on pixel intensities within the captured image. Each of the matrices includes values each corresponding to the pixel intensities within one of the tiles. The matrices are convolved with kernels to generate intensity maps. Each of the kernels is generated based on a corresponding unique pattern of the unique patterns. An extrema value is identified in each of the intensity maps. A location of each of the unique patterns within the image is determined based on the extrema value for each of the intensity maps. A device calibration is performed using the location of each of the unique patterns.
Patent WO-2021236582-A1 (WO)
Title: Isolated lubrication system for drill bits
Inventor: SURESH SWETHA
IPC: E21B10/25
Filed: 2021-05-18
Abstract: An isolated lubrication system (200) for a drill bit (100) is disclosed. The system (200) comprises a body (105) having a cutting arm (106, 107, 108) with a journal (115) and a rotary cutter (109, 110, 111) mounted on the journal (115). The system (200) also comprises a reservoir (135) in a body (105) to contain a fluid lubricant (140) that is isolated from communication outside the body (105). The system (200) also comprises multiple conduits (145, 150, 155) in communication with the reservoir (135) and with respect to each other. The multiple conduits (145, 150, 155) facilitate lubrication between the journal (115) and the rotary cutter (109, 110, 111), including the bearings (120, 125, 130), by means of a gravitational force and/or a centrifugal force acting of the fluid lubricant (140). Further, the system (200) comprises a sealing system (201). The sealing system (201) includes a sealing cap (165) provided to the reservoir (135), a seal (180) provided between the journal (115) and the rotary cutter (109, 110, 111), and a stepped passageway (185) provided in a clearance (175) between the rotary cutter (109, 110, 111) and a cutting arm (106, 107, 108) of the body (105).
Patent WO-2021236650-A1 (WO)
Title: Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
Inventor: STRUM JAY COPELAND
IPC: C07D487/14
Filed: 2021-05-18
Abstract: This invention is in the area of cell cycle inhibiting compounds for the treatment of disorders involving abnormal cellular proliferation, and include selective CDK2 inhibitors for medical therapy and their pharmaceutically acceptable salts and compositions.
Patent WO-2021242809-A1 (WO)
Title: Systems and methods for image capture
Inventor: DZITSIUK YEVHENIIA
IPC: G06K9/36
Filed: 2021-05-26
Abstract: Images subject to panoramic image stitching are analyzed for suitability in three dimensional construction. Effects of translation changes between cameras are mitigated. The dioptric relationship of subject content of the images to the camera set identifies camera translation changes, and eligible camera position inputs, permissible to avoid parallax errors. Images within permissible ranges of each other are stitched to create panoramic images of subject content that a camera cannot fully capture with a single image. Registration plane selection based on translation distances between cameras, and permissible translation changes based on detected subject content depth are disclosed.
Patent WO-2021247975-A1 (WO)
Inventor: MORGAN DYLAN
IPC: C02F1/00
Filed: 2021-06-04
Abstract: A drinking water disinfection system (200) includes a contact tank (202). Drinking water enters the contact tank (202) at water inlet (204) and exits the contact tank (202) at drinking water outlet (222). A circuitous water path from the water inlet (204) to the water outlet (222) is defined by partitions (218). The system (200) further includes an entry sensor system (214), a controller (216) and an exit sensor system (220). The entry sensor system (214) includes one or more sensors for sensing values indicative of a concentration of the disinfecting agent in the water. The controller (216) is operative to receive output signals from the sensor system (214) and to process such signals to assist in controlling the amount of disinfecting agent added to the water at the disinfectant inlet (208).
Patent WO-2021257703-A1 (WO)
Title: Surveillance camera upgrade via removable media having deep learning accelerator and random access memory
Inventor: KALE POORNA
IPC: G06N3/08
Filed: 2021-06-16
Abstract: Systems, devices, and methods related to a Deep Learning Accelerator and memory are described. For example, a removable media (e.g., a memory card, or a USB drive) may be configured to execute instructions with matrix operands and configured with: an interface to receive a video stream; and random access memory to buffer a portion of the video stream as an input to an Artificial Neural Network and to store instructions executable by the Deep Learning Accelerator and matrices of the Artificial Neural Network. Such a removable media can be used to replace an existing removable media used in a surveillance camera to record video or images. The Deep Learning Accelerator can execute the instructions to generate analytics of the buffer portion using the Artificial Neural Network, enabling the surveillance camera that is upgraded via the use of the removable media to provide intelligent services based on the analytics.
Patent WO-2021263166-A1 (WO)
Inventor: ZHOU HEYUE
IPC: C07K16/28
Filed: 2021-06-25
Abstract: The present disclosure provides PD-1 binding proteins, particularly anti-PD-1 antibodies, or antigen-binding portions thereof, that specifically bind PD-1 and uses thereof. In one embodiment, the anti-PD-1 antibody comprises an antigen binding portion that binds a human PD-1 epitope or a non-human PD-1 epitope. Various aspects of the anti-PD-1 antibodies relate to antibody fragments, single-chain antibodies, pharmaceutical compositions, nucleic acids, recombinant expression vectors, host cells, and methods for preparing and using such anti-PD-1 antibodies. Methods for using the anti-PD-1 antibodies include  in vitro  and  in vivo  methods for binding PD-1, blocking interaction between PD-1 and PD-L1, detecting PD-1, and treating diseases associated with PD-L1 over-expression or PD-L1 detrimental expression.
Patent WO-2022006245-A1 (WO)
Title: Network-implemented integrated modeling system for genetic risk estimation
Inventor: KEREN DAVID
IPC: G06N5/02
Filed: 2021-06-30
Abstract: A network-implemented integrated modeling system for genetic risk estimation uses guideline factor information and other input information to determine models usable for estimating genetic risk of disease in patients. Models are determined using established network connections with external sources. Health history information is collected from a patient, which is then processed against a relevant model to estimate the genetic risk of a disease corresponding to that model in that patient. Based on results of the estimation, a pedigree chart representing personal and family risk for the patient is generated and output to the patient and/or health care representatives of the patient. The results may be disseminated to one or more distributed computing environments from a central server which performs the genetic risk estimation. In some cases, follow-up validations performed using further collected data are used to update the constraints used to determine the models.
Patent WO-2022015824-A1 (WO)
Title: Pallet stabilization adhesive
Inventor: THOMAS RICHARD W
IPC: C09J199/00
Filed: 2021-07-14
Abstract: A biodegradable adhesive, comprising: % (Parts) Water: 30.43 Defoamer:.67 Gelatin: 13.50 Preservative:.40 Glycerin, sorbitol, and/or sorbitol solutions and/or a mixture of glycerin, sorbitol and/or sorbitol solutions: 12.00 NaCl: 2.00 Sugar: 41.00 Vanilla Extract:.27 Total Parts: 100.00%
Patent WO-2022132235-A1 (WO)
Inventor: PETERSEN CHRISTOPHER MICHAEL
IPC: G06Q20/38
Filed: 2021-07-26
Abstract: Various embodiments are directed to processing conversions of digital assets to other digital assets. An example method includes determining a source exchange rate for a source digital asset and a fiat currency, determining a target exchange rate for a target digital asset and a fiat currency, and generating an aggregated conversion rate for the source digital asset and the target digital asset using the source exchange rate and the target exchange rate. The method further includes executing a digital asset conversion, which includes causing source digital asset units to be debited from a source digital asset user account and causing target digital asset units to be credited to a target digital asset user account, and subsequently executing fiat currency transactions (e.g., settlements) with a first digital asset exchange system associated with the source digital asset and a second digital asset exchange system associated with the target digital asset.
Patent WO-2022055640-A1 (WO)
Title: System and method for providing technical support and home appliance recommendations to a consumer
Inventor: HATAMBEIKI ARSHAM
IPC: G06F3/16
Filed: 2021-08-05
Abstract: A first data that identifies a first device is used to identify within a data store a one or more capabilities of the first device. When a voice input having one or more keywords that have been pre-associated within the data store to an operational problem associated with at least the first device is received, a system causes a state of at least the first device at a time at which the voice input is received to be identified, causes the one or more keywords, the one or more capabilities of the first device, and the state of at least the first device to be used to identify within the data store a set of instructions for interacting with at least the first device to solve the operational problem, and causes the set of instructions to be presented to a user.
Patent WO-2022035685-A1 (WO)
Title: First radio access technology (rat) channel state feedback (csf) to increase accuracy of interference estimates from second rat neighbor cells with dynamic spectrum sharing (dss)
Inventor: RASSAM FARIS
IPC: H04W16/14
Filed: 2021-08-05
Abstract: A user equipment (UE) receives, from a base station, a message including at least one reporting configuration and resource configuration for a number of channel state information-interference measurement (CSI-IM) resource patterns associated with a first radio access technology (RAT). Each of the configured CSI-IM resource patterns corresponds to a time and frequency location in a resource block of a neighbor cell associated with a second RAT. The UE transmits one or more CSI reports based on the reporting configuration(s) and the resource configuration(s).
Patent WO-2022060736-A1 (WO)
Inventor: MACKAY JAMES
IPC: A61K45/06
Filed: 2021-09-14
Abstract: La présente invention concerne des compositions et des méthodes pour le traitement du psoriasis pustuleux palmo-plantaire.
Patent WO-2022093465-A1 (WO)
Inventor: CEN XI
IPC: C23C16/06
Filed: 2021-09-28
Abstract: Method for forming tungsten gap fill on a structure, including high aspect ratio structures includes depositing a tungsten liner in the structure using a physical vapor deposition (PVD) process with high ionization and an ambient gas of argon or krypton. The PVD process is performed at a temperature of approximately 20 degrees Celsius to approximately 300 degrees Celsius. The method further includes treating the structure with a nitridation process and depositing bulk fill tungsten into the structure using a chemical vapor deposition (CVD) process to form a seam suppressed boron free tungsten fill. The CVD process is performed at a temperature of approximately 300 degrees Celsius to approximately 500 degrees Celsius and at a pressure of approximately 5 Torr to approximately 300 Torr.
Patent WO-2022081575-A1 (WO)
Title: Dispositif télescopique d'évacuation de fumée destiné à être utilisé avec un instrument chirurgical portatif
Inventor: KLEYMAN GENNADY
IPC: A61B18/00
Filed: 2021-10-12
Abstract: L'invention concerne un dispositif d'évacuation de fumée destiné à être utilisé avec un instrument chirurgical portatif, qui comprend un corps tubulaire allongé ayant des parties d'extrémité proximale et distale opposées, la partie d'extrémité proximale du corps tubulaire étant conçue et configurée pour communiquer avec une source d'aspiration et la partie d'extrémité distale du corps tubulaire étant conçue et configurée pour admettre la fumée générée au niveau d'un site chirurgical, et des moyens de fixation pour fixer le corps tubulaire à l'instrument chirurgical portatif.
Patent WO-2022081762-A1 (WO)
Title: Compositions et méthodes pour améliorer la santé de la peau et pour le traitement et la prévention de maladies, troubles et états associés à des champignons et autres microbes pathogènes
Inventor: BRUCKER ROBERT
IPC: A61K35/74
Filed: 2021-10-13
Abstract: La divulgation concerne, entre autres, des compositions et des méthodes d'utilisation d'Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, de Bacillus subtilis ou de Janthinobacterium lividum isolées chez l'humain ou synthétiques. Les compositions peuvent améliorer la santé de la peau. Les méthodes peuvent comprendre l'application d'Alcaligenes faecalis, de Bacillus altitudinis, de Bacillus pumilus, de Bacillus subtilis, ou de Janthinobacterium lividum isolées chez l'humain ou synthétiques sur un hôte ou une zone d'un hôte, telle que la peau ou une muqueuse afin de réduire au minimum la présence d'un ou plusieurs microbes pathogènes, de maximiser les effets thérapeutiques d'un ou plusieurs agents thérapeutiques supplémentaires et/ou d'améliorer la santé d'un hôte ou d'une zone hôte. Une méthode pour réduire au minimum un microbe pathogène peut comprendre l'application sur une surface d'une composition comprenant Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis ou Janthinobacterium lividum isolées chez l'humain ou synthétiques et un vecteur acceptable. Les compositions et les méthodes peuvent comprendre un prébiotique ou un autre microbe afin de maximiser la croissance et/ou les métabolites (par exemple, résultant de la croissance d'un probiotique). Les compositions et les méthodes peuvent comprendre des métabolites d'Alcaligenes faecalis, de Bacillus altitudinis, de Bacillus pumilus, de Bacillus subtilis, ou de Janthinobacterium lividum isolées chez l'humain ou synthétiques.
Patent WO-2022093747-A1 (WO)
Title: Contextual data security
Inventor: SCHMUGAR CRAIG
IPC: G06N3/02
Filed: 2021-10-26
Abstract: There is disclosed in one example a computing apparatus, including: a hardware platform including a processor and a memory; a network interface; a userspace application store including a plurality of userspace applications, wherein at least some of the userspace applications are programmed to communicate via the network interface; and instructions encoded within the memory to: enumerate social connections of a user via the userspace applications; assign the social connections to virtual groups according, at least in part, to correlated connection services; assign data transfer policies to the virtual groups; detect an attempted data transfer to a social connection; and enforce the data transfer policy for a virtual group of the social connection of the attempted data transfer.
Patent WO-2022119903-A1 (WO)
Title: Laterally heterogenous wavelength-converting layer
Inventor: BOHMER MARCEL RENE
IPC: H01L33/44
Filed: 2021-12-01
Abstract: A laterally heterogenous wavelength-converting optical element includes pixel regions surrounded by border regions; each includes down-converting phosphor particles bound by a coating or solid medium. The pixel regions are aligned with LEDs of an array. The phosphor regions differ with respect to one or more of compositions, particle sizes, coating thicknesses, refractive indices, or voids (size, number density, or volume fraction). Those difference(s) can result in the border regions exhibiting larger optical scattering, which can improve contrast of down-converted light emitted by adjacent pixels of the array.
Patent WO-2022125642-A1 (WO)
Title: Composant réagissant avec l'isocyanate, composition le comprenant, et mousse formée avec celui-ci
Inventor: BALIJEPALLI SUDHAKAR
IPC: C08G18/16
Filed: 2021-12-08
Abstract: Une composition réagissant avec l'isocyanate comprend (A) un polyol, (B) un polysiloxane, et (C) un composé d'alcool de polyéther. Une composition pour préparer une mousse comprend la composition réagissant à l'isocyanate, (D) un polyisocyanate, (E) un catalyseur, et (F) un agent de soufflage. La composition forme une mousse sur au moins des composants (A) et (D) réagissant en présence de composants (E) et (F).
Patent WO-2022133306-A1 (WO)
Title: Wind speed indicator
Inventor: KHAN HAROON
IPC: B66C15/06
Filed: 2021-12-17
Abstract: A solid-state anemometer mounted to an upper location of a load boom and detecting a wind speed reading at the upper location on the load boom. A wireless transmitter communicatively coupled to the solid-state anemometer and obtains the wind speed reading and wirelessly transmits the same to a receiver.
Patent WO-2022076977-A1 (WO)
Title: Protéine de fusion comprenant une protéine capsidique de circovirus, et particules pseudo-virales chimériques composées de cette dernière
Inventor: ANSTROM DAVID
IPC: A61P31/20
Filed: 2021-10-04
Abstract: La présente invention se rapporte à des polypeptides construits par recombinaison, utiles pour préparer des vaccins, en particulier pour réduire un ou plusieurs signes cliniques provoqués par une infection par au moins un pathogène, tels que des signes cliniques provoqués par une infection virale. Plus particulièrement, la présente invention est relative à un polypeptide comprenant une protéine de capside de circovirus liée à une protéine hétérologue ou à un fragment de cette dernière, et à des particules pseudo-virales chimériques composées de tels polypeptides. Dans un exemple, une protéine de fusion est fournie qui comprend une protéine PCV2 ORF2 liée à un fragment immunogène de protéine VP8 de rotavirus, et qui est utilisable pour réduire un ou plusieurs signes cliniques, la mortalité ou l'excrétion fécale provoquée par une infection à rotavirus chez le porc.
Patent WO-2022077033-A1 (WO)
Title: Alimentation et refroidissement sans coupure pour des applications à alimentation critique
Inventor: KOERNER MATTHEW DOUGLAS
IPC: H05K7/20
Filed: 2021-10-08
Abstract: L'invention concerne un système (100, 200, 600, 700) comprenant un dispositif de mesure (103, 203, 603, 703) pour recevoir une première énergie électrique provenant d'une source d'alimentation (101, 201, 601, 701) et fournir au moins une partie de la première énergie électrique à un centre de données (120, 220, 620, 720) pendant une première période de temps. Le système comprend également un dispositif de conversion d'énergie électrique-mécanique (105, 205, 605, 705) pour convertir de l'air en un état comprimé ou liquéfié à l'aide d'au moins la partie de la première énergie électrique. Le système comprend également un récipient de stockage (107, 207, 607, 707) pour recevoir l'air et stocker l'air à l'état comprimé ou liquéfié. Le système comprend également un dispositif de conversion d'énergie mécanique-électrique (109, 209, 609, 709) pour : recevoir l'air provenant du récipient de stockage dans un état gazeux comprimé ; générer une seconde énergie électrique pour alimenter le centre de données ; et faire échapper de l'air refroidi à fournir au centre de données pour refroidir les dispositifs électroniques.