baber/WOPTO huggingface dataset:
Patent CU-24627-B1 (CU)
Title: Derivados de imidazolidin-2-ona sustituidos como inhibidores de prmt5
Inventor: CHIKKANNA DINESH
IPC: C07D403/14
Filed: 2019-03-20
Abstract: <p>La presente invención se refiere a derivados de imidazolidin-2-ona sustituidos de la fórmula (I).</p> <p>ESPACIO PARA LA FORMULA</p> <p>La presente invención proporciona además los métodos de preparación del compuesto de la fórmula (I) y su utilidad como inhibidor de PRMT5. Los compuestos son útiles como medicamentos en el tratamiento de afecciones y trastornos mediados por PRMT5, tales como cáncer, trastornos metabólicos, inflamación, enfermedades autoinmunes y hemoglobinopatías.</p>
Patent EP-1101460-B1 (EP)
Inventor: MINGOZZI FRANCO
IPC: A61F2/00
Filed: 2000-06-26
Granted: 2005-04-20
Abstract: A hip endoprosthesis, comprising a metaphyseal portion (2) which is blended, on a distal side, with a rod-shaped portion (3) and has, on a proximal side, a taper-fit coupling (5,6) for a collar (7) from which a coupling stem (8) protrudes obliquely for a spherical head for the articulation of the endoprosthesis to the pelvic bone; the metaphyseal and rod-shaped portions (2,3) have a polygonal cross-section and the metaphyseal portion (2), below the stem (8), protrudes beyond a peripheral region of the collar (7), forming a step (11) which forms a recess (12) together with the stem. <IMAGE>
Patent EP-1180397-B1 (EP)
Inventor: MUSSMANN LOTHAR DR
IPC: B01J37/18
Filed: 2000-08-19
Granted: 2007-03-28
Abstract: Production of oxygen-storing material based on cerium oxide with a further oxide of silicon or zirconium comprises initially forming hydroxide precursors of the mixed oxide using a wet chemical method; drying the precursors at 80-300 degrees C forming an oxide/hydroxide/carbonate mixture; and treating the dried mixture in an atmosphere containing hydrogen at 600-900 degrees C for 1-10 hours.
Patent EP-1174449-B1 (EP)
Inventor: SALAZAR UHAGON FRANCISCO BORJA
IPC: C08F297/04
Filed: 2000-07-20
Granted: 2006-09-06
Abstract: The block monoalkenyl aromatic hydrocarbon and 1,3-conjugated diene block copolymer of general formula (I) + (II), wherein A represents a monoalkenyl aromatic hydrocarbon polymeric block, B represents a conjugated 1,3-diene polymeric block, X represents a divinyl benzene core, n is 0 or 1, m is from 2 to 10, the amount of block copolymer according to formula (II) varies from 0 to 20 % by weight, the molar ratio A1/A2 varies from 90/10 to 60/40, the molar ratio B1/B2 varies from 99.5/0.5 to 75/25, and the monoalkenyl aromatic hydrocarbon content of the polymer varies from 20 to 45 % by weight. The copolymer can be obtained by a process comprising anionically polymerizing both monoalkenyl aromatic hydrocarbon and 1,3-conjugated diene, optionally repeating both polymerizations, coupling said polymeric chains to divinylbenzene and finishing the active chains. The composition of waterproofing membranes includes a bitumen component and between 7 and 15% by weight of said copolymer. <CHEM>
Patent EP-1046349-B1 (EP)
Inventor: BERG MORTEN
IPC: A24B3/16
Filed: 2000-04-18
Granted: 2004-03-03
Abstract: The straight laying apparatus comprises of a feed conveyor (1) and a perpendicularly running belt conveyor (6). Tobacco leaves (7) are transferred to from the feed conveyor to the belt conveyor via a series of projecting partitions (5) mounted to a frame assembly (4). The partitions are arranged parallely and form a series of channels that orientate the leaves as they pass. An independent claim is included for a method of straightlaying tobacco leaves using the described apparatus.
Patent EP-1145219-B1 (EP)
Inventor: EKHAUS IRA
IPC: G10H1/12
Filed: 2000-01-12
Granted: 2012-08-15
Abstract: L'invention concerne la capacité à mesurer, décomposer et recomposer uniquement les forces et vibrations d'instruments de musique à cordes. Un système (48) de traitement de signaux fonctionne au moyen de plusieurs détecteurs (4, 5, 6) sensibles au déplacement, à la vitesse, à l'accélération, et/ou à l'énergie des vibrations des cordes en vue de générer des signaux de détection qui sont traités par un processeur de signaux, de manière à produire des signaux resynthétisés correspondant au déplacement, à la vitesse, à l'accélération, et/ou à l'énergie des vibrations des cordes d'un second instrument de musique à cordes. Cette méthodologie aboutit sur des détecteurs et des configurations de mesure, des techniques de traitement, et des résultats visant à recréer des caractéristiques particulières d'instruments de musique à cordes.
Patent EP-1144461-B1 (EP)
Inventor: WESTMIJZE HANS
IPC: C08F2/20
Filed: 2000-01-06
Granted: 2004-03-31
Abstract: The invention relates to aqueous peroxide emulsions, optionally containing anti-freeze and/or further additives, which contain a specific emulsifier system comprising a copolymer of an  alpha , beta -unsaturated dicarboxylic acid and a C8-24  alpha -olefin, the acid groups of which are esterified with an ethoxylated alcohol having a degree of ethoxylation of 1-45, as well as an ethoxylated fatty alcohol with an HLB-value greater than 16.
Patent EP-1076932-B1 (EP)
Inventor: KAHLMANN JOSEPHUS A H M
IPC: H03M5/14
Filed: 2000-02-18
Granted: 2008-05-21
Abstract: A device is disclosed for encoding a stream of databits of a binary source signal (S) into a stream of databits of a binary channel signal (C), wherein the bitstream of the source signal is divided into n-bit source words (x1, x2), which device comprises converting means (CM) adapted to convert said source words into corresponding m-bit channel words (y1, y2, y3). The converting means (CM) are further adapted to convert n-bit source words into corresponding m-bit channel words, such that the conversion for each n-bit source word is parity inverting (table I) (FIG. 1). The relations hold that m>n>=1, p>=1, and that p is an odd integer that can vary. Preferably, m=n+1. Further, a decoding device is disclosed for decoding the channel signal obtained by means of the encoding device.(FIG. 5).
Patent EP-1151589-B1 (EP)
Inventor: GONIKBERG MARK
IPC: H04L25/497
Filed: 2000-02-11
Granted: 2009-01-14
Abstract: A reduced state maximum likelihood sequence estimator allows the use of improved equalization techniques that provides greatly improved performance for channels with severe attenuation and spectral nulls. The reduced state maximum likelihood sequence estimator retains k<SUB>n </SUB>states of a total number of K states, k<SUB>n</SUB><K, with each retained state having an associated state metric. (J)(k<SUB>n</SUB>) new states are determined based on k<SUB>n </SUB>previous states and a most recently received sample, using J transitions, J being a less than L, where L is a size of a symbol alphabet. (J)(k<SUB>n</SUB>) new state metrics are determined which are respectively associated with each new state. The new state metrics are compared to a threshold and those states whose metric does not exceed the threshold are retained. The reduced complexity of the MLSE allows for the use of partial response equalizers, e.g., a partial response class V (PRV) equalizer. The number of retained states k<SUB>n </SUB>varies according to an adaptive threshold which limits the number of retained states between a lower bound and an upper bound. The threshold may be determined according to the metric of the most likely state of the retained states and a selected one of a plurality of transition metrics associated with the most likely state metric.
Patent EP-1165042-B1 (EP)
Title: Drinkable ibuprofen pharmaceutical suspension
Inventor: LEBON CHRISTOPHE
IPC: A61K31/485
Filed: 2000-04-06
Granted: 2005-02-02
Abstract: The invention relates to a drinkable ibuprofen solution wherein the soluble fraction of the active ingredient contained therein is less than 10% by weight in relation to the weight of the suspension.
Patent EP-1189844-B1 (EP)
Inventor: HARTMAN TERRY E
IPC: C03B11/12
Filed: 2000-03-16
Granted: 2006-09-27
Abstract: A cooling system for use with a glassware machine having a plunger, a mold and a valve. The system includes a supply of cooling fluid such as air. The system further includes devices for cooling the plunger, the mold and the valve that are in communication with the supply of fluid.
Patent EP-1086166-B1 (EP)
Inventor: RIGOSI GIAN LUIGI
IPC: C08J5/12
Filed: 2000-03-13
Granted: 2005-02-02
Abstract: La présente invention concerne un procédé permettant d'effectuer un couplage entre une matière plastique et une surface métallique, qui consiste à appliquer une poudre d'une composition de polymère adhésive sur la surface métallique, puis à surmouler cette surface métallique avec une matière plastique par injection et enfin, à chauffer la surface métallique.
Patent EP-1165965-B1 (EP)
Inventor: RIETSCHLE DIETER
IPC: F04D23/00
Filed: 2000-03-24
Granted: 2003-07-30
Abstract: A side channel compressor comprises an inlet port (42) for gas and an outlet port (44) for compressed gas as well as a side channel (32) which provides a flow connection between the inlet port (42) and the outlet port (44), the cross-section of the side channel (32) diminishing between the inlet port (42) and the outlet port (44). The side channel (32) has at least one section in which it has a cross-section in the form of a half ellipse and in which the maximum depth of the channel (32) continuously diminishes towards the outlet port (44).
Patent EP-1177259-B1 (EP)
Inventor: PALUMBO PAUL S
IPC: C09C3/08
Filed: 2000-03-10
Granted: 2007-10-24
Abstract: The present invention relates to cationic pigments having an organic group which comprises: a) at least one aromatic group, at least one C1-20 alkyl group, or both; and b) at least one cationically charged ionic group, at least one cationically chargeable ionizable group or both, and a corresponding counter-anion. The cationic pigments of the present invention have been found useful in aqueous or solvent based compositions and particularly in ink compositions, especially ink jet ink compositions. A method for preparing the cationic pigments is also disclosed.
Patent EP-1192247-B1 (EP)
Inventor: PITSON STUART MAXWELL
IPC: A61K48/00
Filed: 2000-05-12
Granted: 2006-04-12
Abstract: The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.
Patent EP-1099264-B1 (EP)
Inventor: DIJKSTRA PETER
IPC: B25F5/00
Filed: 2000-04-13
Granted: 2005-04-20
Abstract: Cet appareil électrique (1) comprend un porte-piles (5) que l'on peut insérer dans un évidement (4) ménagé dans l'appareil. Ce porte-piles est verrouillé dans l'appareil au moyen d'un mécanisme de verrouillage (8) comprenant des taquets souples (9, 10) placés sur le porte-piles (5), réalisés dans une matière plastique et présentant des éléments saillants (13, 14), le mécanisme de verrouillage comprenant également un bossage (15) agencé dans l'évidement (4) de l'appareil, aux fins de coopération avec les éléments saillants (13, 14). Des lamelles métalliques élastiques (ressorts lames (26), (27)) soutiennent les taquets en matière plastique (9, 10) et conduisent également le courant, des piles (7) à l'appareil.
Patent EP-1178783-B1 (EP)
Inventor: KOCH ANDREAS
IPC: A61K9/70
Filed: 2000-05-17
Granted: 2004-04-21
Abstract: The invention relates to a device and a method for increasing the transdermal permeation of medicaments. The invention is characterized in that a constituent which effects a local increase in temperature and/or an increase in blood flow of the skin is administered in addition to the transdermally applied active substance.
Patent EP-1182931-B1 (EP)
Inventor: SORENSEN ALLEN PAUL
IPC: A01N43/90
Filed: 2000-06-02
Granted: 2005-12-28
Abstract: L'invention concerne une composition partagée (de préférence biocide) comprenant, dans une première phase liquide (de préférence organique), un premier ingrédient actif (de préférence biocide), et dans une seconde phase liquide (de préférence aqueuse à un pH acide), un second ingrédient actif (de préférence biocide). L'ingrédient actif compris dans la première phase liquide est chimiquement instable dans les conditions de ladite seconde phase liquide. Eventuellement, des particules peuvent être suspendues dans au moins la phase aqueuse préférée et, de préférence, ces particules sont elles-mêmes biocides. Grâce à cette composition, on peut préparer une composition anthelmintique chimiquement et physiquement stable à partir d'au moins deux agents actifs anthelmintiques incompatibles (à savoir, une lactone macrocyclique (par exemple, l'ivermectine) et le lévamisole et, de préférence, au moins un troisième agent anthelmintique (par exemple, un benzimidazole (par exemple, l'albendazole)).
Patent EP-1198690-B1 (EP)
Inventor: DEPPNER KARL-HEINZ
IPC: F27D13/00
Filed: 2000-06-08
Granted: 2003-08-13
Abstract: The aim of the invention is to create a pre-heating device which has an overall simple structural shape, which is provided for pre-heating feed materials, especially scrap metal, and which is used in a metallurgical smelting aggregate. The pre-heating device comprises a housing provided with a material feed opening which is located on the upper end thereof and which can be closed by a closure element, and provided with an ejection opening which is located on the lower end thereof and which is joined to the metallurgical smelting aggregate. A material transporting device and means for conducting hot furnace gases through the pre-heating device are also provided. In order to realize the inventive pre-heating device, the invention provides that at least one base plate (6, 7) is provided which is fastened to the housing wall and whose end (16, 17) located in the interior extends only so far inside the housing as to maintain a fall shaft (14, 15) between this end and the opposing housing wall. A material transporting device is provided as a pushing device (8, 9) arranged directly above each base plate (6, 7). The pushing element of said pushing device can be displaced along each base plate in order to push the fed material (3) into the fall shaft (14, 15), said material being held in the housing shaft by the base plate (6, 7) and being heated by hot furnace gas streams.
Patent EP-1101016-B1 (EP)
Inventor: KEMPER HANS
IPC: F01L9/20
Filed: 2000-05-25
Granted: 2002-09-18
Abstract: A method for controlling an electromagnetic actuator operating a gas exchange valve in an internal combustion piston engine. Between two electromagnets an armature, connected to the gas exchange valve, is reciprocated by a return spring between the electromagnets whose alternating energization moves the valve into open and closed positions. The lift of the armature is detected by a sensor array during its movement from one pole face to the other. Depending on the detected actual values of the armature lift, the energy flow to the electromagnets is controlled such that the armature moves at a speed tending to zero at a predetermined distance range from the pole face of the capturing electromagnet. At the end of the lift motion, the current flow through the capturing electromagnet is guided in such a way that the armature is maintained oscillating at a short distance from the pole face of the capturing electromagnet.
Patent EP-1119111-B1 (EP)
Inventor: KONDO RYOICHI
IPC: H03F1/56
Filed: 2000-07-27
Granted: 2007-04-18
Abstract: L'invention concerne un isolateur comprenant un substrat diélectrique multicouche, un circuit d'amplification de puissance à haute fréquence, un élément isolant et des éléments de circuit formés sur la substance diélectrique multicouche. Le circuit d'amplification de puissance à haute fréquence et l'élément isolant sont formés intégralement sur le substrat diélectrique multicouche et reliés par le biais des éléments de circuit.
Patent EP-1203142-B1 (EP)
Inventor: PAFFRATH HOLGER
IPC: F02M26/41
Filed: 2000-08-09
Granted: 2004-04-21
Abstract: The invention relates to an internal combustion engine comprising at least one line system for secondary air. A module body comprises a portion of the lines (25, 30, 35), a portion of the actuating valves (26a, 31, 26b), and check valves (27). The throttle valve (13) and its actuator (36) are additionally integrated in said module. A line section (14) which is part of the intake system (11) is also integrated in the module. The admissions of the lines (35, 30) are easily realized in said line section. The line (30) is intended for recirculating exhaust gas. It is also possible to partially realize the depicted idea with regard to integration. It is also possible to simultaneously utilize the supply line (29) in the exhaust (21) of the internal combustion engine as a bleed line for the exhaust gas. All of these measures are suited for reducing the installation space and the number of components for the internal combustion engine, whereby they yield very economical solutions.
Patent EP-1226498-B1 (EP)
Title: Traitement multifilaire rapide pour multiprocesseurs  etroitement lies
Inventor: KRANICH UWE
IPC: G06F9/30
Filed: 2000-07-31
Granted: 2007-08-15
Abstract: L'invention concerne une architecture processeur contenant plusieurs processeurs à liaison intime sous forme d'un système multiprocesseur symétrique. Ce mécanisme spécial de liaison permet à ce système d'exécuter avec une grande efficacité et de manière spéculative plusieurs unités d'exécution en parallèle. Généralement, le système d'exploitation est chargé de programmer différents unités d'exécution parmi les processeurs disponibles dans un système multiprocesseur. Un des problèmes associés avec le traitement multifilière en parallèle réside dans le fait que la surcharge liée à la programmation des unités d'exécution destinées à être exécutées par le système d'exploitation est telle que les segments de code courts ne peuvent pas profiter efficacement du traitement multifilière. En conséquence, les améliorations potentielles de rendement dus au traitement multifilière en parallèle ne sont pas réalisables. Des circuits additionnels sont inclus sous la forme d'un système multiprocesseur symétrique qui permet la programmation et l'exécution spéculative de plusieurs unités d'exécution sur plusieurs processeurs sans la participation et la surcharge inhérente du système d'exploitation. L'exécution multifilière en parallèle est plus efficace et la performance peut s'en trouver améliorée.
Patent EP-1145326-B1 (EP)
Inventor: HIJZEN ERWIN A
IPC: H01L29/40
Filed: 2000-07-17
Granted: 2009-09-09
Abstract: L'invention porte sur un transistor à effet de champ du type tranchée -grille comprenant une plaque de champ (38) disposée sur un matériau diélectrique (28) dans une tranchée périmétrique (18). Le matériau diélectrique (28) forme une couche plus épaisse que la couche diélectrique de grille (21) les tranchées (11) du réseau. La plaque de champ (38), reliée à la source (3) ou à la grille de tranchée (31) du transistor agit vers l'intérieur en direction du réseau cellulaire plutôt que vers l'extérieur en direction du périmètre du corps (15) en raison de sa présence sur la paroi intérieur (18a) de la tranchée (18) sans agir sur aucune des parois extérieures (18b). Les tranchées (11, 18) du réseau et du périmètre sont suffisamment rapprochées, et les zones intermédiaires (4a, 4b) de la région (4) de dérive du drain suffisamment peu dopées, pour que la couche d'appauvrissement(40) formée dans la région (4) de dérive du drain lorsque le transistor est à l'état bloquant appauvrisse la totalité des zones intermédiaires comprises entre les tranchées voisines pour une tension inférieure à la tension de claquage. Cette disposition réduit les risques de claquage prématuré pouvant se produire pour des champs élevés dans la couche d'appauvrissement (40), surtout sur le périmètre du réseau cellulaire.
Patent EP-1307258-B1 (EP)
Inventor: ECKMILLER ROLF
IPC: A61N1/36
Filed: 2000-07-13
Granted: 2008-04-30
Abstract: The invention relates to a system for the protection of neuroprosthesis operation against unauthorized access to the function or operating data. The system is assigned to neuroprostheses for treating functional disorders of the nervous system. This neuroimplant protection system (NIS) comprises at least one neuroprosthesis component which is in contact or operational connection with nerve tissue. Neuroprosthesis operation takes place only during the period of a specific authorization and/or comprises an authorized data transmission between external component and implanted component and/or an authorized communication for monitoring and/or defining the neuroprosthesis functional state. The communication between external and implanted component is in encrypted form.
Patent EP-1206188-B1 (EP)
Inventor: BIERINGER HERMANN
IPC: A01N43/90
Filed: 2000-07-22
Granted: 2004-02-25
Abstract: The invention relates to a herbicidally active agent that contains a mixture from A) a herbicidally active amount of one or more compounds of the formula (I), wherein X and Y are the same or different and represent  hydrogen, halogen, for example fluorine, chlorine, bromine or iodide, Z represents -S-CHR<1>-COOR<2>, wherein R<1> represents hydrogen or C1-C20 alkyl, preferably C1-C6 alkyl, R<2> represents C1-C20 alkyl, C3-C8 cycloalkyl or C1-C10-alkoxy-C1-C10-alkyl, preferably C1-C6 alkyl, C4-C6 cycloalkyl or C1-C4-alkoxy-C1-C4 alkyl, or -COOR<3>, wherein R<3> represents C1-C20 alkyl, preferably C1-C6 alkyl, or Y and Z together represent a group -O-CHR<4>-CO-NR<5>- that forms a ring with the phenyl ring, wherein R<4> represents hydrogen or C1-C20 alkyl, preferably C1-C6 alkyl, and R<5> represents C1-C20 alkyl, C2-C20 alkenyl or C2-C20 alkinyl, preferably C1-C6 alkyl, C3-C5 alkenyl or C3-C5 alkinyl; and B) an antidotically effective amount of one or more safeners.
Patent EP-1204752-B1 (EP)
Inventor: THONNARD JOELLE
IPC: C12N1/21
Filed: 2000-07-27
Granted: 2008-06-25
Abstract: The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
Patent EP-1198379-B1 (EP)
Inventor: BAIER TORSTEN
IPC: B60L15/20
Filed: 2000-07-18
Granted: 2003-09-17
Abstract: The invention relates to a device (5) for a rail vehicle having a control unit (10) that calculates the moment of disconnection after which the rail vehicle will coast and reach on time the next stop planned according to the timetable while meeting said timetable by considering a position measured value (S) indicating the location of the rail vehicle, the stored distance data, a time measured value (t) indicating the corresponding time, a stored timetable, a speed measured value (V) indicating the speed of the rail vehicle and the coasting data describing the coasting performance of the rail vehicle when the drive mechanism is disconnected. In order to reliably save travel energy even in case of operational disruptions, the device (5) has a data input (E5) by means of which a timetable modification parameter ( DELTA t) can be fed into the device (5) and the control unit (10) is embodied in such a way that it forms the disconnection moment taking into account said timetable modification parameter ( DELTA t).