baber/WOPTO huggingface dataset:
Patent DE-69305352-D1 (DE)
Inventor: DYSON NORMAN
IPC: C07D405/06
Filed: 1993-06-17
Granted: 1996-11-14
Abstract: This invention provides an improved process for the preparation of compounds of formula (I):    <IMAGE>  (I)  wherein: n is 0, 1 or 2; each R1 is independently halo or lower alkyl; R2 is nitro or -N(R3)R4 where R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, lower alkylsulfonyl or -C(Y)R5 where Y is oxygen or sulfur and R5 is hydrogen, lower alkyl, lower alkoxy or -N(R6)R7 where R6 is hydrogen or lower alkyl and R7 is hydrogen, lower alkyl or lower alkoxycarbonyl; or R3 and R4 together with N is pyrrolidino, piperidino, morpholino, thiomorpholino or piperazino, wherein the piperazino is optionally substituted at the 4-position by -C(O)R8 where R8 is hydrogen, lower alkyl, lower alkoxy or amino; or pharmaceutically acceptable salts thereof. These compounds are useful in treating disease-states characterized by hypercholesterolemia.
Patent DE-69306872-D1 (DE)
Inventor: CAMPAU DANIEL N
IPC: H01M50/673
Filed: 1993-06-30
Granted: 1997-02-06
Abstract: A battery refill system is described for filling and maintaining a number of interconnected battery cells (18) at a predetermined level with liquid provided by an external liquid supply. The refill system includes a number of refill valves (20), each associated with a single battery cell (18), and a main supply valve (14) which connects the battery cells (18) to the liquid supply. Tubing (12) is provided for connecting the battery cells in a chain or serial relationship. The tubing (12) is fabricated from a polymeric material which is substantially free of plasticizer bleed such as a thermoplastic elastomer or a fluorocarbon or fluoroelastomer or a fluoropolymer and which has a minimum bend radius of about 2.50 inches (64 mm). The tubing (12) is capable of a service temperature range of between about -20 DEG F and 200 DEG F (-29 DEG C and 93 DEG C), and has a burst pressure of up to about 40 psi (2.76 x 10<5>Pa). Additionally, the tubing (12) has a five-year minimum life, and does not degrade excessively when exposed to sulfuric acid, oil, ozone, or ultraviolet radiation. The tubing (12) has an ultimate elongation of at least 250% at 73 DEG F (23 DEG C), to accommodate various barbed fittings. <IMAGE>
Patent DE-69312963-D1 (DE)
Inventor: TAYLOR MARGARET JOAN
IPC: A61K35/12
Filed: 1993-12-07
Granted: 1997-09-11
Abstract: There is disclosed a method for improving the effectiveness of a drug comprising the steps of encapsulating the drug in liposome membranes and loading the thus encapsulated drug into cells extracted from the intended patient.
Patent DE-69312988-D1 (DE)
Inventor: SEIDEL RANDY R
IPC: B65H29/66
Filed: 1993-03-11
Granted: 1997-09-18
Abstract: A device (1) for stacking and destacking a stream of imbricated, substantially planar, flexible units (18) to form or destack a layered stack (25). The device is a stacker, adapted to receive a stream of units from a source thereof, and a plurality of transfer sheets (15). The feeder delivers the stream of units to the stacker. The stacker has staging belts (14) which receive portions of the stream and deposit the units (18) serially on one of the transfer sheets (15), as it is withdrawn from the sheet stack (16). This forms an imbricated layer of the units and the transfer sheet (15). The stacker deposits the imbricated layer on a removable support and repeats the cycle to deposit successive imbricated layers on the preceding layers. Destacking is carried out by simply reversing the process. <IMAGE>
Patent DE-69316112-D1 (DE)
Inventor: BRUMMOND BARBARA ANN
IPC: G01N33/94
Filed: 1993-08-04
Granted: 1998-02-12
Abstract: Labeled carbamazepine analogues of Formula (I) are disclosed. The analogues are used immunoassay dry elements and immunoassays for detecting carbamazepine. The elements are preferably dry, thin film analytical elements comprising a labeled carbamazepine analogue. <CHEM>
Patent DE-69316617-D1 (DE)
Inventor: LINDH LEIF
IPC: A61F2/50
Filed: 1993-06-02
Granted: 1998-02-26
Abstract: PCT No. PCT/SE93/00492 Sec. 371 Date Dec. 2, 1994 Sec. 102(e) Date Dec. 2, 1994 PCT Filed Jun. 2, 1993 PCT Pub. No. WO93/24080 PCT Pub. Date Dec. 9, 1993A foot prosthesis has a support part and a foot element which cooperates with the support part. The foot element includes a forefoot part which is displaceable axially along the support part. The foot element further includes a heel part which is fixed on the lower end of the support part. A setting arrangement sets the position of the forefoot part along the support part in relation to the heel part.
Patent DE-69326259-D1 (DE)
Inventor: BARTHOLOMEW DONALD DEKLE
IPC: F16L37/12
Filed: 1993-11-16
Granted: 1999-10-07
Abstract: In its preferred embodiment, a quick connector (10) for connecting a male conduit (12) to a female receptacle (14) has a pair of waist segments (60 and 62), a body segment (56), and a pair of leg segments (68). Each of the leg segments (68) are defined by a pair of projecting elements (76) which are at least partially compressible toward one another thereby causing the pair of waist segments (60 and 62) to move toward one another. A confirmer ring (114) is provided on the pair of projecting elements (76). Confirmation that the quick connector (10) is properly locked in place is made when the confirmer ring (114) is fully seated within a portion of the opening (18) of female receptacle (14). An alternate embodiment provides for use of the confirmer ring (114) as an installing tool when connecting the male conduit (12) with the female receptacle (14). An additional alternate embodiment allows usage of the confirmer ring (114) as a tool for installation and decoupling of the male conduit (12) into the female receptacle (14), as well as for confirming the connection.
Patent DE-69412233-D1 (DE)
Inventor: JOSEPH ALICE
IPC: B05D7/00
Filed: 1994-03-25
Granted: 1998-09-10
Abstract: In coating metal units or structures with a heat-hardening powder based on a polyester resin and/or an epoxy resin, which is sprayed on by means of an electrostatic spray gun and then polymerised in an oven, the pieces to be coated are pre-treated by: (a) an electrolytic zinc plating; and (b) application of a coat of varnish, followed by drying, baking or polymerisation of the varnish. This coating acts as a bonding underlayer between the metal and the polyester and/or epoxy resin outer coating. Pref. the varnish is acrylic and is polymerised in an oven. The thickness of the varnish layer is 2-30 (5-15) microns. The varnish is applied by dipping or spraying.
Patent DE-69424681-D1 (DE)
Inventor: BUONGIORNO LIVIO
IPC: C08L23/02
Filed: 1994-10-28
Granted: 2000-06-29
Abstract: A method of making the a multilayer, biaxially oriented, heat shrinkable thermoplastic film includes a layer having between 50 and 100 parts by weight ethylene/alpha-olefin C4-C12 copolymer, and between 0 and 50 parts by weight of a polymer selected from polyolefin, and modified polyolefin, the layer having more than one melting point when detected by diffential scanning calorimetry according to ASTM D-3418; wherein the total thickness variation in the multilayer film is lower than ±10%.
Patent DE-69424775-D1 (DE)
Inventor: KRUEGER K
IPC: C10N40/22
Filed: 1994-12-12
Granted: 2000-07-06
Abstract: An aqueous functional fluid composition free of formaldehyde and formaldehyde producing agents, more especially an aqueous metalworking fluid composition, having improved resistance to attack by microorganisms is provided. This fluid comprises a) water, b) a water soluble or dispersible functioning agent (e.g. water soluble or dispersible organic lubricant) and c) an antimicrobial effective amount of the combination of d) a water soluble or dispersible nitrogen bearing organic compound (e.g. monoethanolamine) and e) a water soluble or dispersible haloalkynylalkyl carbamate (e.g. 1-iodo-3-propynylbutyl carbamate).
Patent DE-69432056-D1 (DE)
Inventor: DOMAGALA MICHAEL
IPC: A61P31/04
Filed: 1994-10-26
Granted: 2003-02-27
Abstract: The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
Patent DE-69512523-D1 (DE)
Inventor: NILSSON EIVOR
IPC: D04B1/24
Filed: 1995-07-31
Granted: 1999-11-04
Abstract: A method for producing knitted ready-made garments type waistcoat or jacket includes the step of: knitting a piece of tricot (10) having a rectangular configuration with two long sides (12, 13), two short sides (11) and at least two fold markings (18, 19, 21, 23, 24); folding the piece of tricot in at least two places, substantially in parallel with the short sides (11) for forming the back (14) and side parts (15) of the jacket; forming the remaining parts of the tricot piece at the short sides a divided front (16) with a substantially v-shaped front neck part; making an arm opening at each side part of the tricot piece; knitting each divided front part (16) with two or more fold markings (18, 19, 21, 23, 24), of which at least two of these markings (18, 19) extend substantially from the respective long side and meet each other in a vertex (20) at a distance from the short sides (11) of the tricot piece; and folding each divided front part (16) along the fold markings and is joined together to at least double thickness.
Patent DE-69514378-D1 (DE)
Inventor: BLASS MOSES
IPC: B29L7/00
Filed: 1995-10-02
Granted: 2000-02-10
Abstract: A dental floss comprises or consists of an integral PTFE tape. At the opposite faces of said tape the respective coefficients of friction are different, e.g. due to different degrees of sintering.
Patent DE-69525775-D1 (DE)
Inventor: RELLO ROBERT MICHAEL
IPC: B65C9/18
Filed: 1995-11-20
Granted: 2002-04-11
Abstract: A method and apparatus is disclosed for applying a label onto a substantially cylindrical article. The label drum (32) defines an article wrapping position. A thin layer, heat activated adhesive backed label (5) is fed onto a label receiving position of the drum. The label receiving positions of the drum are formed of a substantially smooth, resilient material, such as silicon. The label drum is rotated to move the label retained thereon into the article wrapping position. As the label is moved, the adhesive is heated so that the adhesive obtains a sufficient temperature to melt. A jet of air is blown onto the resilient surface for cooling the surface during subsequent label applying and ensuring rapid cooling of melted adhesive during labeling.
Patent DE-69528359-D1 (DE)
Inventor: BIANCHI MARINA
IPC: C07C275/38
Filed: 1995-01-19
Granted: 2002-10-31
Abstract: This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone compounds of formulae <CHEM>  or <CHEM> wherein all groups designated as X represent GhyCH or GhyCCH3, Ghy being a guanylhydrazone group, X2 in the first formula, and X'1, X'2 and X'3 in the second formula can also represent H, and all the other groups have the meanings given in the specification, compositions and their use to inhibit the uptake of arginine by macrophages and/or its conversion to urea. These compounds, compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.
Patent DE-69528471-D1 (DE)
Inventor: SMEDS ANNA-LISA
IPC: C12P21/02
Filed: 1995-11-14
Granted: 2002-11-07
Abstract: PCT No. PCT/SE95/01350 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Nov. 14, 1995 PCT Pub. No. WO96/15140 PCT Pub. Date May 23, 1996The present invention relates to a process for purifying recombinant coagulation factor VIII by loading an aqueous solution containing factor VIII onto a hydrophobic interaction chromatography (HIC) gel, wherein at least one surfactant is present in the aqueous solution and/or a buffer solution used to equilibrate the gel prior to loading the aqueous solution onto the gel. The presence of a surfactant when loading the solution containing factor VIII onto the HIC gel, makes it possible to efficiently separate the intact and active factor VIII molecules from molecules with structural deviations. With the present invention it is further possible to reduce the content of DNA and/or CHO cell contaminants considerably and increase the activity of the factor VIII product to a hitherto unknown extent. The invention further relates to an aqueous solution containing recombinant factor VIII which has been purified according to the present process and use of such an aqueous solution, for the manufacture of a medicament for administration to a patient having the symptoms of hemophilia. Also, the invention relates to a method for treatment of hemophilia by administration of a therapeutically effective amount of recombinant factor VIII which has been purified according to the present process.
Patent DE-69530760-D1 (DE)
Inventor: ONO TAKUJI
IPC: A23L3/10
Filed: 1995-03-06
Granted: 2003-06-18
Abstract: An inert gas-filled cooking system is disclosed which provides for quick sterilization of food in inert gas-filled packages in a manner that prevents deterioration of food quality as well as assures a long taste guaranteed period by raising the temperature of a hot water to be applied onto the food packages in a sterilization tank so as to satisfy the retort sterilization requirements. The sterilization tank is pressurized at a predetermined value by control of an analog pressure regulating valve. The temperature of the hot water flowing from a heat exchanger into the sterilization tank is varied in a multi-staged fashion to follow a predetermined sterilization temperature-time curve by control of an analog steam regulating valve and a steam superheater. The hot water is applied onto the packaged food for sterilization. <IMAGE>
Patent DE-69534165-D1 (DE)
Inventor: BARKATS MARTINE
IPC: A61P1/16
Filed: 1995-07-26
Granted: 2005-05-25
Abstract: The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical compositions.
Patent DE-69607890-D1 (DE)
Inventor: KATO KANEYOSHI
IPC: C07C271/60
Filed: 1996-06-20
Granted: 2000-05-31
Abstract: A compound represented by the formula: <CHEM> wherein Ar<1> and Ar<2> independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic hydrocarbon group optionally containing O or S; R<1> represents H, acyl group, etc.; and X represents an electron-withdrawing group, an optionally substituted aromatic group, a group of the formula: <CHEM> wherein R<2> and R<3> independently represent H, acyl group or an optionally substituted hydrocarbon group, etc., etc.; or salts thereof are useful as an excellent anti-neurodegenerative agent.
Patent DE-69607948-D1 (DE)
Inventor: LAIDLER OSWALD
IPC: B05B15/52
Filed: 1996-02-28
Granted: 2000-05-31
Abstract: A hollow body having a nozzle opening to discharge fluid as a jet or spray; the body comprising a first part having an inlet to admit fluid under pressure into the first part, and a second part movable relative to the first part and said first and second parts are relatively movable from an abutting position in which they define therebetween the nozzle opening and a fluid feed passage in the body and leading to the nozzle opening, and a cleaning position in which the fluid feed passage is split open longitudinally and the nozzle opening is split open to expose the nozzle and passage defining and abutting surfaces of said parts, for cleaning.
Patent DE-69611487-D1 (DE)
Inventor: BARBER PATRICK P
IPC: F16L19/03
Filed: 1996-06-11
Granted: 2001-02-15
Abstract: A gasket assembly is provided for fluid couplings. The gasket assembly includes a gasket (10;210) having an outer circumferential surface including arc segments defining a minor outside diameter and a plurality of ears (20,22;220,222,221) projecting outwardly from the arc segments to define a major outside diameter for the gasket. The gasket assembly further includes a split cylindrical sleeve (24;224) having a plurality of slots disposed and dimensioned for loosely receiving the ears of the gasket. The sleeve and the gasket are dimensioned such that the ears project outwardly beyond the sleeve to define gripping protrusions that facilitate mounting and removal of the gasket assembly onto the coupling component. <IMAGE>
Patent DE-69621223-D1 (DE)
Inventor: CHENEY CRAIG
IPC: F16L9/12
Filed: 1996-01-11
Granted: 2002-06-20
Abstract: The invention relates to an elongated fuel and vapor tube (10) used in conjunction with an internal combustion engine in a motor vehicle system to handle fluids containing hydrocarbons comprising a first layer (12) disposed radially innermost, and a second layer (14) having a second predetermined thickness greater than the thickness of the first layer, the second layer uniformly connected to the first layer and consisting essentially of a melt processible thermoplastic capable of sufficiently permanent laminar adhesion to the first layer to prevent delamination during desired lifetime of the tube, wherein the melt processible thermoplastic contains quantities of a conductive material sufficient to provide electrostatic dissipation capacity sufficient to prevent build up of electrostatic charge.
Patent DE-69628368-D1 (DE)
Inventor: AONO TETSUYA
IPC: C07D401/14
Filed: 1996-03-15
Granted: 2003-07-03
Abstract: A novel compound of the formula: A-Z-Ar<1>-CO-Ar<2> wherein A is a condensed pyrimidinone or condensed pyridazinone ring; Ar<1> and Ar<2> are independently a ring; Z is a divalent group, or a salt thereof which have an excellent antitumor activity.
Patent DE-69631872-D1 (DE)
Inventor: LAMBERT DIDIER
IPC: B01J19/00
Filed: 1996-04-09
Granted: 2004-04-22
Abstract: Method of controlling a process, e.g. a separation, blending or chemical reaction or polymerisation, for which a material X is a feed or a product, in order to keep substantially constant the value Vc of a property P of said product or the product of said process from said feed, or the yield of said process, which method comprises measuring the absorption Dix of said material at more than one wavelength in the region 600-2600nm, comparing signals (i) indicative of said absorptions or a mathematical function thereof with signals (ii) indicative of absorptions Dim at the same wavelengths or a mathematical function thereof for at least 2 standards Sm for which the said property or yield has a known value V, at least one of said standards Smc having a value Vc for said property or yield and controlling said process to ensure that said standard Smc or standard(s) Smc is the standard or standards having the smaller or smallest average value of the absolute difference at each wavelength i between the signal for said material and the signal from the standard Sm. <IMAGE>
Patent DE-69637442-D1 (DE)
Inventor: KAMODA OSAMU
IPC: A61K47/48
Filed: 1996-12-20
Granted: 2008-04-03
Abstract: A drug composition which comprises a combination of 4-Ä4-(4-methylbenzyloxycarbonyl)phenylÜphenyl trans-4-guanidinomethylcyclohexanecarboxylate or an acid addition salt thereof and a cyclodextrin, especially  beta -cyclodextrin, and is suitable for removing or exterminating Helicobacter pylori ; and a composite of the same.
Patent DE-69700823-D1 (DE)
Inventor: BALDISSARUTTI WALTER
IPC: G02C5/22
Filed: 1997-06-21
Granted: 1999-12-30
Abstract: Hinge for connecting a shaft (11) to the corresponding end part (A) of a frame (C) for spectacles, in which said end is made of metal wire and folded in the form of at least one first arm (2) and one second arm (3), lying in different planes and splayed with respect to one another, one (3) of said arms having the free end folded so as to form a pin (4) on which there is inserted a cam element (13) fixed to one end (12) of said shaft (11), wherein said cam element (13) has at least two adjacent surfaces (13a, 13b) substantially perpendicular to one another and defining at least one first corner (13c) and at least one second corner (13d), said surfaces (13a, 13b) and corners (13c, 13d) acting in sequence on said pin and on said first arm (2) of the end (A) of the support frame (C) of the spectacles so as to cause an elastic recall reaction on said pin (4) both during opening/closing of the shaft and in the event of forced splaying from the open position thereof. <IMAGE>
Patent DE-69701362-D1 (DE)
Inventor: HOLMBERG HANS
IPC: B27M3/00
Filed: 1997-06-17
Granted: 2000-04-06
Abstract: The invention relates to a process and a device for the manufacturing of a glued block made of triangular cross-sectioned elongated staves of wood. The staves of wood are laid beside each other with alternate staves with their base sides downwards and alternate ones with their base sides upwards, and adhesive applied between adjoining surfaces between the staves. A press (13, 14, 21-33) applies main pressure force to glue the staves firmly together is transverse to the base sides of the staves.
Patent DE-69708881-D1 (DE)
Inventor: PETIVAN L
IPC: G06F11/18
Filed: 1997-05-15
Granted: 2002-01-17
Abstract: A redundant clock system for use in a computer is provided including a first oscillator which produces first reference clock signals; a second oscillator which produces second reference clock signals; a third oscillator which produces third reference clock signals; a first multiplexer which receives the first, second and third reference clock signals from the first, second and third oscillators and which provides a designated one of the received reference clock signals as a selected reference clock signal; a second multiplexer which receives the first, second and third reference clock signals from the first, second and third oscillators and which provides a designated one of the received reference clock signals as a selected reference clock signal; a third multiplexer which receives the first, second and third reference clock signals from the first, second and third oscillators and which provides a designated one of the received reference clock signals as a selected reference clock signal; a first phase-locked loop (PLL) circuit coupled in a first feedback circuit in which the first PLL receives as reference input the selected reference clock signal provided by the first multiplexer and receives as feedback input a first output clock signal; a second phase-locked loop (PLL) circuit coupled in a second feedback circuit in which the second PLL receives as reference input the selected reference clock signal provided by the second multiplexer and which receives as feedback input the a second output clock signal; a third phase-locked loop (PLL) circuit coupled in a third feedback circuit in which the third PLL receives as reference input the selected reference clock signal provided by the third multiplexer and receives as feedback input a third output clock signal; and a reference clock designation unit which determines whether any one of the first, second or third reference clock signals has failed and which designates one of the two other reference clock signals in the event that one of the reference clock signals has failed.