baber/WOPTO huggingface dataset:
Patent FI-950817-A0 (FI)
Inventor: LAVIELLE GILBERT
IPC: A61K31/453
Filed: 1995-02-22
Abstract: Benzodioxane derivs. of formula (I), their enantiomers, diastereomers and epimers, and their acid or base addn. salts, are new. X = O or -CH2-; n = 1-3; R1 = H, aminocarbonyl or hydroxymethyl: R2 = N(R3)R4; R3 = H or 1-6C alkyl; R4 = 1-4C alkyl (opt. substd. by phenyl (opt. substd. by one or more halo, 1-4C alkyl, 1-4C alkoxy, trihalomethyl or hydroxy) provided that R1 is not H), or 1-4C alkyl (substd. by benzoylamino (opt. substd. on the phenyl nucleus)), or benzoyl (opt. substd. are phenyl above), or R3R4N to which they are bonded form a gp. (i); m = 1-3; R5 = benzoyl or benzoylmethyl (both opt. substd. by phenyl), or 1H-imidazol-3-yl methyl or 1,2-benzisoxazol-3-yl methyl(both opt. substd. on phenyl by a halogen atom), or 2-oxo-(3H)-benzimidazol-1-yl.
Patent FI-953478-A0 (FI)
Inventor: PAYNE JOHN DAVID
IPC: C07D275/04
Filed: 1995-07-18
Abstract: PCT No. PCT/GB94/00100 Sec. 371 Date Jul. 19, 1995 Sec. 102(e) Date Jul. 19, 1995 PCT Filed Jan. 19, 1994 PCT Pub. No. WO94/16564 PCT Pub. Date Aug. 4, 1994Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by reacting 0.75 to 1.07 moles alkali metal hydroxide with one mole BIT.
Patent FI-961350-A0 (FI)
Inventor: HOESS EVA
IPC: G01N33/533
Filed: 1996-03-25
Abstract: PCT No. PCT/EP95/02921 Sec. 371 Date Jun. 13, 1996 Sec. 102(e) Date Jun. 13, 1996 PCT Filed Jul. 24, 1995 PCT Pub. No. WO96/03423 PCT Pub. Date Feb. 8, 1996The invention concerns a process for the production of hapten-labelled peptides which is characterized in that (a) a peptide with the desired amino acid sequence is synthesized on a solid phase from amino acid derivatives whose reactive side groups are blocked by protecting groups wherein the protecting groups on primary amino side groups are selected in such a way that, if desired, they can be selectively cleaved off, (b) protecting groups are cleaved to form at least one free primary amino group, (c) a hapten-active ester derivative is coupled to the at least one free primary amino group of the peptide and (d) if desired protecting groups that still remain are cleaved off, the hapten being selected from the group comprising sterols, bile acids, sexual hormones, corticoids, cardenolides, cardenolide-glycosides, bufadienolides, steroid-sapogenines and steroid alkaloids.
Patent FI-962919-A0 (FI)
Inventor: RANDAHL TORBJOERN
IPC: H04M19/02
Filed: 1996-07-19
Abstract: A method and an apparatus for off-hook detection in a subscriber line interface circuit responds to a ringing signal which preferably lacks a DC component. A signal is generated that is a function of the line current through the subscriber line, and the time at which the signal exceeds a predetermined current value is measured. The measured time is compared with a predetermined time value, and an off-hook indication is produced in a processor depending on the comparison.
Patent FI-964196-A0 (FI)
Inventor: WESTERLUND EVA CHARLOTTE
IPC: G06F11/10
Filed: 1996-10-18
Abstract: A method and a circuit device control insertion and storage of digital information in a memory and retrieval of the information from the memory. The method and circuit device ensure the digital information is correctly read out of the memory in the form of a number of coordinated bit positions, and the digital information is used to control one or several functions. The information intended to be inserted into the memory is given an address belonging to the memory. First control-sum-carrying bit positions are calculated from the bit positions of the digital information and their values coming into the memory according to a selected evaluation function. The bit positions of the digital information are stored in an address within the memory, and the first control-sum-carrying bit positions are stored in an address within a control memory. Second control-sum-carrying bit positions are calculated when the bit positions of the digital information stored in the address in the memory are read out according to the selected evaluation function. The bit positions of the read information, and their values, are accepted as correct, and a circuit is activated through a signal on a conductor, if a following comparison between the first and second control-sum-carrying bit positions shows that they are identical.
Patent FI-965074-A0 (FI)
Inventor: MOLDT PETER
IPC: C07D451/02
Filed: 1996-12-17
Abstract: PCT No. PCT/EP95/01358 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28401 PCT Pub. Date Oct. 26, 1995The present invention discloses compounds of the formula,   <IMAGE>    <IMAGE>   any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e dopamine, serotonin, noradrenalin, reuptake inhibitors.
Patent FI-980322-A0 (FI)
Inventor: KUISMA JOUKO
IPC: H05B37/03
Filed: 1998-02-12
Abstract: A method for determining the remaining operating life of a fluorescent lamp (1), when the fluorescent lamp (1) is connected to a starter (2) and the fluorescent lamp (1) comprises cathodes (3). The method is characterized by phases determining the amount of remaining active material in the cathode (3) and producing an alarm signal depending on the amount of remaining active material in the cathode. <IMAGE>
Patent AP-9600810-A0 (AP)
Title: Crystalline n-acetyl neuraminic acid derivatives and processes for their preparation.
Inventor: WILLIAMSON CHRISTOPHER
IPC: C07D309/28
Filed: 1994-12-15
Abstract: Acetamido-2,3,4,5-tetradeoxy-4-guanidino-d-galacto-non-2-enopyranosonic acid in crystalline form, particularly in the form of a hydrate which exits as cryatals having a low aspect ratio, or in the form of a hydrate which exits as crystals having a high aspect ratio.
Patent IL-69199-A0 (IL)
Title: Carbacyclin derivatives,process for their manufacture and pharmaceutical compositions containing them
IPC: C07C405/00
Filed: 1983-07-12
Abstract: Carbacylin derivatives of the general formula I <IMAGE>  in which   R1 denotes a hydrogen atom or the radical OR2, in which R2 can denote hydrogen, alkyl, cycloalkyl, aryl, the radical <IMAGE> or a heterocyclic radical, or R1 can denote the radical NHR3 where R3 denotes an acid radical or the radical R2, n can denote the number 2, 3, 4 or 5, X denotes a hydrogen atom or a fluorine atom,    A denotes a -CH2-CH2-, a trans -CH=CH- or -C IDENTICAL C- group,   W denotes a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> group, in which the OH group can be in the  alpha  or  beta position,    D denotes the group <IMAGE> a straight-chain, saturated alkylene group having 1-5 C atoms, a branched saturated or a straight-chain or branched unsaturated alkylene group having 2-5 C atoms, which may be substituted by fluorine atoms,    m can denote the number 1, 2 or 3,   E represents a direct bond, a -C IDENTICAL C- group or a -CR6=CR7- group, in which R6 denotes a hydrogen atom or an alkyl group having 1-5 C atoms and R7 denotes a hydrogen atom, an alkyl group having 1-5 C atoms or a halogen atom,   R4 denotes an alkyl, cycloalkyl or a substituted or unsubstituted aryl group or a heterocyclic group,    R5 denotes a free or functionally modified hydroxyl group, and, if R2 denotes a hydrogen atom, the salts thereof with physiologically acceptable bases, a process for their preparation and their use as pharmaceuticals.
Patent IL-86488-A0 (IL)
Title: Artificial airway device
IPC: A61M16/04
Filed: 1988-05-25
Abstract: An artificial airway device, for use in place of an endotracheal tube to facilitate lung ventilation in an unconscious patient, is in the form of a laryngeal mask comprising an airway tube (10) opening into the interior space or lumen of a mask portion (12) whose periphery (14), which may be inflatable, is adapted to seal around the inlet (36) to the larynx (38), thus securing the patient's airway, permitting spontaneous or controlled ventilation and preventing inhalation of extraneous matter, means such as cross-bars (21) being provided to prevent obstruction by the epiglottis of the aperture (19) by which the airway tube (10) opens into the lumen of the mask.
Patent IL-86748-A0 (IL)
Title: Process for preparation of intermediates to leukotriene antagonists
IPC: C07C49/83
Filed: 1988-06-15
Abstract: 1,3-Dialkoxybenzenes are acylated and deprotected in a mixture of acetic or propionic acid and hydrobromic acid. The dihydroxyphenones thus produced are intermediates in the synthesis of leukotriene antagonists.
Patent IL-91870-A0 (IL)
Title: Method for controlling insects
IPC: A01N59/00
Filed: 1989-10-03
Abstract: Insects are combatted by treating the insects with a pyrogenically produced and hydrophobic silica. The insects can be sprayed with an aqueous dispersion of the pyrogenically produced and hydrophobic silica. Alternatively, the insects can be dusted with the silica in powdery form.
Patent IL-97571-A0 (IL)
Title: Treatment of polycystic ovarian disease
IPC: A61K31/565
Filed: 1991-03-15
Abstract: Agents which increase the levels of human insulin-like growth factor - 1 binding protein (h-IGFBP-1), such as an estrogen, are used in conjunction with a gonadotropin releasing hormone (GnRH) analogue in the treatment of PCOD and associated infertility.
Patent SE-8202375-A0 (SE)
Title: Av plattor uppbyggd beklädnad, t ex ett av brädor uppbyggt golv
Inventor: BERGER J
IPC: E04F15/04
Filed: 1982-04-15
Abstract: 8 En beklddnad är uppbyggd av plattor (1), vilka ligger vid sidan av varandra kantyta (2) mot kantyta (2), varvid plattorna (1) dr sammanfogade tvd och tvd medelst en fAstprofil (3). Fastprofilen (3) dr av ett elastiskt material s6_som plast, och uppvisar pa omse sidor av sitt mittplan (4-4) tva utat skjutande byre fldnsar (5) pa inbOrdes avstand. De Ovre flansarna (5) är i sndppingrepp med tva ldngsgdende utskdrningar (7,8) i Varje plattas (1) kantyta (2) och bottenyta (9). Beklddnaden ãr enkel att montera av en icke fackman. Beklddnaden kan an- vandas som ett av brader uppbyggt golv. Fdstprofilen (3) kan ha ett tvarsnitt, vars form i stort sett motsVarar ett ankare. Fig. 1.
Patent AU-PO502297-A0 (AU)
Title: Liquid purification apparatus
IPC: C02F1/50
Filed: 1997-02-10
Abstract: The invention relates to a liquid purification apparatus (10) adapted to employ the purifying affects of the heavy metal silver under electrolysis. The apparatus (10) has a chamber (14) formed with spaced apart inlet and outlet openings (16,18) whereby liquid can flow through chamber (14) from inlet opening (16) to outlet opening (18). An electrolytic unit (20) has at least two spaced apart silver electrodes (22,24) mounted in chamber (14) in the path of the liquid flow. An electric circuit means (32) controls operation of electrodes (22, 24) with a first timing means (62) for providing a pulsed current to electrodes (22,24). <IMAGE>
Patent FI-20010643-A0 (FI)
Inventor: VOELMEKE EGON
IPC: E03D13/00
Filed: 2001-03-28
Abstract: The urinal (1) has a flushing water connection (5) and a waste water connection (6), and consist of an inner and an outer section. The inner section (1a) is a shaft, open at the top, with an inclined guide surface (3a) extending from top back to bottom front. The outer part (1b) has a similar inclined guide surface (3b) projecting inwards. The guide surfaces define a gap (7) at the flushing water intake. The lower end of the first guide surface and the outer wall of the inner section define a gap (9), which is positioned under the water level (W) in an overflow chamber (10).
Patent IL-101353-A0 (IL)
Title: Pharmaceutical compositions for treating diabetes
IPC: A61K38/28
Filed: 1992-03-24
Abstract: This invention concerns the use of rapamycin alone or in combination with insulin in prophylactically preventing the onset, arresting the development, or retarding the progression of insulin dependent diabetes mellitus in a mammal.
Patent IL-101589-A0 (IL)
Title: 1-(pyrido(3,4,b)-1,4-oxazinyl-4-yl)-1h-indoles,intermediates and a process for their preparation,and their use as medicaments
IPC: C07D401/14
Filed: 1992-04-14
Abstract: This invention relates to compounds of the formula <CHEM>  wherein     R1 is hydrogen or loweralkyl;     R2 is hydrogen or loweralkyl; and R3 is hydrogen, loweralkyl, halogen, nitro, amino, hydroxy, loweralkoxy, benzyloxy or <CHEM> where R4 is hydrogen or loweralkyl and R5 is loweralkyl, aryl or arylloweralkyl, or R4 and R5 taken together form a heterocyclic ring selected from the group consisting of <CHEM> wherein R6 is hydrogen, loweralkyl, aryl or arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful for alleviating depression and various memory dysfunctions characterized by a cholinergic or adrenergic deficit, such as Alzheimer's Disease, and can, therefore, be used as medicaments.
Patent IL-101989-A0 (IL)
Title: Nasal dilator
IPC: A61F13/12
Filed: 1992-05-25
Abstract: A nasal dilator 10 that prevents the outer wall tissue 60, 62 of the nasal passages 54, 56 of the nose 12 from drawing in during breathing comprises a truss member 16. The truss member 16 includes flexible strip of material 18 having a first end region 20, a second end region 22 and an intermediate segment 24. The first and second end regions 20, 22 are adapted to engage the outer wall tissue 60, 62 of first and second nasal passages 54, 56 of the nose 12. The truss member 16 further includes resilient bands 30a, 30b secured to the strip of material 18. The resiliency of the bands 30a, 30b acts to stabilise the outer wall tissue 60, 62 and thereby prevents the outer wall tissue 60, 62 of the nasal passages 54, 56 from drawing in during breathing. The first and second end regions 20, 22 are secured to the outer wall tissue 60, 62 by an adhesive layer whose effect is less at the intermediate segment 24.
Patent IL-110369-A0 (IL)
Title: Pharmaceutical compositions for the prevention and/or treatment of gastrointestinal diseases including ulcer
IPC: A61P1/00
Filed: 1994-07-19
Abstract: The subject-matter of the invention is the use of 2-[phenylmethylene]-1-[3'-(amino)-2'-(hydroxy)-propoxy-imino]-cyclohexane derviates of formula <CHEM>  wherein   R and R1   independently mean hydrogen or halogen atom(s), Ro   stands for hydrogen or a C1-4 alkoxy group, R2 and R3   independently represent hydrogen atom(s), straight and/or branched chain C1-8 alkyl group(s), optionally substituted by a dimethylamino group, or C2-6 alkenyl or C3-7 cycloalkyl group(s) or R2 and R3   together with the nitrogen atom to which they are attached form a 6-membered heterocyclic group containing an additional nitrogen atom, which latter optionally may bear a phenyl group, optionally substituted by a C1-4 alkoxy group, and their stereoisomers and optical isomers and mixtures thereof as well as pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives thereof, optionally in admixture with 1 or more carrier(s) commonly used in pharmaceutical compositions, for preparing medicaments having gastroprotective and antimicrobial including antiulcer activity.
Patent IL-118766-A0 (IL)
Title: Improved infusion apparatus
IPC: A61M5/14
Filed: 1996-07-01
Abstract: PCT No. PCT/IL97/00218 Sec. 371 Date Jun. 10, 1999 Sec. 102(e) Date Jun. 10, 1999 PCT Filed Jun. 30, 1997 PCT Pub. No. WO98/00186 PCT Pub. Date Jan. 8, 1998A multi-drug intravenous infusion apparatus which comprises a plurality of vials containing drugs to be provided to a patient; a fluid container containing fluid to be mixed with the drugs; conduit mechanism for leading drugs from the vials, mixed with the fluid from the container, to mechanism for introducing the drugs with the fluid into the patient's body, the conduit mechanism comprising: a main section, a plurality of individual sections, each comprising at least a collapsible portion, connected to the vials and to the main sections, a terminal section connected to the main section and the mechanism for introducing the drugs with the fluid into the patient's body, and a fluid section leading fluid from the fluid container to the terminal section; a switching unit comprising a plurality of switches, each one associated with one of the individual sections, wherein each switch is capable of either blocking the drug flow in the associated section by exerting pressure whereby to collapse the collapsible portion thereof or allowing the flow by releasing the collapsible portion; and a programmable processor for managing and regulating the operations of the switching unit.
Patent IL-125292-A0 (IL)
Title: Process for the preparation of tetraalkyl 1,2,3, 4-butanetetracarboxylates
Inventor: BAGLEY MELVIN R
IPC: C07C55/00
Filed: 1997-01-10
Abstract: Electrolytic hydrodimeric coupling of dialkyl maleates in alkanol solutions containing an alkanol-soluble alkali metal alkoxide/quaternary ammonium tetrafluoroborate mixed supporting electrolyte yields tetraalkyl 1,2,3,4-butanetetracarboxylates.
Patent IL-131883-A0 (IL)
Title: A process for the preparatin of an aminoalcohol
IPC: C07C215/10
Filed: 1998-04-01
Abstract: PCT No. PCT/EP98/01874 Sec. 371 Date Oct. 4, 1999 Sec. 102(e) Date Oct. 4, 1999 PCT Filed Apr. 1, 1998 PCT Pub. No. WO98/45247 PCT Pub. Date Oct. 15, 1998A process for the preparation of 3-amino-1,2-propanediol, commonly known as isoserinol, having an organic impurities content lower than 0.1% and an inorganic impurities content lower than 0.05%.
Patent IL-142438-A0 (IL)
Title: Diagnostic and therapeutics for sepsis
IPC: C12Q1/6883
Filed: 1999-11-01
Abstract: Methods and kits for detecting polymorphism that are predictive of a subject's susceptibility to developing sepsis are described.
Patent IL-148289-A0 (IL)
Title: A process for the preparation of a frozen confection
IPC: A23G9/14
Filed: 2000-09-15
Abstract: The present invention concerns a process for the preparation of a fat-containing, foamed, frozen confection, wherein said preparation is carried out according to the following steps :      the ingredients of the fat-containing confection are mixed together, said mixture is pasteurised and homogenised or homogenised and pasteurised,    the homogenised mixture is submitted to a at least two-steps cooling, wherein the first step corresponds to a temperature decrease from the pasteurisation or homogenisation temperature to around 10-35  DEG C and the second step from 10-35 DEG C to around 1 to 10  DEG C and a holding time is applied between both cooling steps,    the cooled mixture is maintained at the temperature of around 1 to 10  DEG C during at least 0.1 hour and the cooled mixture is freezed with an incorporation of air or another gas before or during freezing.
Patent IL-148600-A0 (IL)
Title: Method for the detection of oxidized forms of soluble guanylate cyclase and a method for screening post activators of soluble guanylate cyclase with oxidized haem iron
IPC: G01N33/50
Filed: 2000-08-19
Abstract: The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
Patent IL-149444-A0 (IL)
Title: A composition containing an angiotensin ii antagonist for the treatment of glaucoma
IPC: A61K31/353
Filed: 2000-12-01
Abstract: An agent for the prophylaxis or treatment of glaucoma, which comprises an angiotensin II antagonist and at least one compound selected from adrenaline receptor blockers, prostaglandins and carbonic anhydrase inhibitors as active ingredients for simultaneous, separate or successive use of these active ingredients.
Patent IL-156752-A0 (IL)
Title: Gene for identifying individuals with familial dysautonomia
IPC: C12Q1/6883
Filed: 2002-01-07
Abstract: This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is characterized by widespread sensory and variable autonomic dysfunction. Previously, we mapped the FD gene, DYS, to a 0.5 cM region of chromosome 9q31 and showed that the ethnic bias is due to a founder effect, with >99.5% of disease alleles sharing a common ancestral haplotype. To investigate the molecular basis of FD, we sequenced the minimal candidate region and cloned and characterized its 5 genes. One of these, IKBKAP, harbors two mutations that can cause FD. The major haplotype mutation is located in the donor splice site of intron 20. This mutation can result in skipping of exon 20 in the mRNA from FD patients, although they continue to express varying levels of wild-type message in a tissue-specific manner. RNA isolated from patient lymphoblasts is primarily wild-type, whereas only the deleted message is seen in RNA isolated from brain. The mutation associated with the minor haplotype in four patients is a missense (R696P) mutation in exon 19 that is predicted to disrupt a potential phosphorylation site. Our findings indicate that almost all cases of FD are caused by an unusual splice defect that displays tissue-specific expression; and they also provide the basis for rapid carrier screening in the Ashkenazi Jewish population.
Patent IL-164418-A0 (IL)
Title: Device for controlling gemstone polishing assembl y movement
IPC: B24B9/16
Filed: 2004-10-05
Abstract: The present invention pertains to a device for controlling polishing assembly movement. The device comprises a vertical rod, a motive power means for lowering and lifting, and rotating, oscillating, or both rotating and oscillating the vertical rod about an axis of rotation coaxial with the vertical rod. The device also comprises a pin that is offset from the axis of rotation and connected to the vertical rod for mounting the polishing assembly. Optionally, the device may comprise a sensor for activating movement of the vertical rod. <IMAGE>
Patent IL-195868-A0 (IL)
Title: New ruthenium complexes as catalysts for metathesis reactions
Filed: 2008-12-11
Abstract: Disclosed are novel metathesis catalysts of the formula wherein R1, R2, R3, R4, R5, R6, X1, X2, L and Y are as described herein, a process for making the same and their use in metathesis reactions such as ring closing or cross metathesis.