baber/WOPTO huggingface dataset:
Patent AT-E231150-T1 (AT)
Inventor: WOOD HAMISH C S
IPC: A61K31/505
Filed: 1987-09-03
Granted: 2003-02-15
Abstract: The present invention relates to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present invention provides a process for the preparation of a desired substantially pure (6R or 6S) diastereoisomer of a derivative of tetrahydrofolic acid or salt or ester. The process comprises the steps of: attaching a chiral auxiliary group at either N-5 or N-10 of a mixture of 6R and 6S diastereoisomers of tetrahydrofolic acid, separating the new diastereoisomers, recovering the desired new diastereoisomer (6R or 6S) corresponding to the desired (6R or 6S) diastereoisomer, and converting the substantially pure new diastereoisomer recovered into the corresponding diastereoisomer.
Patent AT-E219243-T1 (AT)
Inventor: KNOLL WOLFGANG
IPC: G01N21/41
Filed: 1994-03-11
Granted: 2002-06-15
Abstract: Device for laterally resolved investigation of a laterally heterogeneous ultra-thin object layer (5), especially for laterally resolved detection of a change in the layer thickness of the object layer (5) which results from a specific binding reaction of a first binding partner fixed on the object layer (5) with an unbound second binding partner, having a multilayer layer structure extending in an examination region, which contains the object layer (5) as the first layer and a second layer neighbouring the latter, a coupling arrangement for launching (injecting, input coupling) excitation light (9) into the second layer, the excitation light (9), at at least one defined angle of incidence, generating a confined (bound, trapped) non-radiating electromagnetic wave in the second layer, from which wave an evanescent wave extends into the object layer (5), and an optical imaging system (11) for imaging the examination region of the object layer (5) in an image plane (12) under a defined angle of incidence, at which detection light is extracted (coupled out) from the second layer. The coupling arrangement has an optical grating structure extending parallel to the object layer (5) in the examination region, which grating structure can be rotated about an axis (A) running perpendicularly to the grating plane (27) in order to alter the orientation of the grating lines relatively to the incidence plane for adjusting the imaging contrast. <IMAGE>
Patent AT-E152655-T1 (AT)
Inventor: GEIPL HERBERT DIPL-ING
IPC: B23K9/16
Filed: 1994-08-16
Granted: 1997-05-15
Abstract: Shielding gas is continuously introduced adjacent to the electrode at the weld site, said gas being present at a concn. of 20-5000 vpm, pref. 50-3000 vpm (0.005-0.30 vol.%) and contg. principally Ar and/or He, plus heavy noble gases (e.g. Kr, Xe) and/or table, elementary diatomic or triatomic gases (e.g. H2, O2, CO2, CO, N2O and NO2) and/or gaseous, stable inorganic cpds., pref. C1-C4 hydrocarbons (CH4, C2H4) having ionisation energies of 8-17 eV, pref. 8-14.3 eV.
Patent AT-E163147-T1 (AT)
Inventor: KIPPE MICHAEL
IPC: B23B51/02
Filed: 1994-06-07
Granted: 1998-02-15
Abstract: The invention pertains to a rotary-driven stock-removing tool, in particular a drill or milling cutter, with at least one curved cutting edge at its end face which in drilling and milling work can be advanced into the workpiece in the direction of the rotational axis. To improve the tool-wear characteristics, the invention proposes that the angle ( alpha ) between the cutting-edge tangent (b) and the circumferential speed vector (c) at any point of the cutting edge, over the entire length of the cutting edge, is less than 90 DEG  and greater than or equal to 55 DEG . This yields a particularly even load on the cutting edge and a markedly increased tool life. The indicated angle ( alpha ) is preferably constant over the entire length, or at least long segments, of the cutting endge.
Patent AT-E147231-T1 (AT)
Inventor: CORBIN DAVID RICHARD
IPC: A01H5/00
Filed: 1994-06-24
Granted: 1997-01-15
Abstract: 3-Hydroxysteroid oxidase controls insects, particularly lepidopterans and boll weevil. Genes encoding for this enzyme may be cloned into vectors for transformation of plant-colonizing microorganisms or plants, thereby providing a method of controlling insect infestation.
Patent AT-E201668-T1 (AT)
Inventor: HUYNH ANH HOA
IPC: A61K49/00
Filed: 1994-09-14
Granted: 2001-06-15
Abstract: PCT No. PCT/FR94/01077 Sec. 371 Date Jun. 11, 1996 Sec. 102(e) Date Jun. 11, 1996 PCT Filed Sep. 14, 1994 PCT Pub. No. WO95/07888 PCT Pub. Date Mar. 23, 1995Method for the preparation of high purity substituted benz[e]indoles corresponding to the general formula    <IMAGE>  (I)  comprising the preparation of an arylhydrazine which is subjected to a Fischer indole synthesis with a suitable ketone, the benz[e]indole thus obtained being reacted with a radical R6, followed by subjection to a purification step. This method may more particularly be applied to the synthesis of Indocyanine Green.
Patent AT-E176199-T1 (AT)
Inventor: JUNG ULRICH DR
IPC: B41F27/12
Filed: 1995-05-11
Granted: 1999-02-15
Abstract: The method involves turning the cylinder (1), a tension load is exerted on the block (2), which is secured to the cylinder (1), in the peripheral direction (FU). In addition to this load, axial tension loads (FA) are exerted in opposite axial directions on the block periphery, and all loads can be arranged to act only on the outer block edges. At each edge of the block there can be a pressure roller (3), movable in and out of position in relation to the cylinder (1), their axes of rotation including an angle with the cylinder axis. The roller are in mirror-image positions in relation to the central plane which is at right angles to the cylinder axis. Thus when the rollers press against the block at the edges axial tension loads are generated.
Patent AT-E196486-T1 (AT)
Inventor: NEUENSCHWANDER PETER
IPC: A61L27/00
Filed: 1995-07-31
Granted: 2000-10-15
Abstract: Biocompatible multi-block copolymers (I) contg. at least two chemically different block components are obtd. by linear polycondensation of an alpha,omega-dihydroxy-polyester (II) (obtd. by transesterification of poly-(R)-3-hydroxybutyric acid or a 3-hydroxybutyric/3-hydroxyvaleric acid copolymer with ethylene glycol) either with another alpha,omega-dihydroxy-polyester (III) or with an alpha,omega-dihydroxy-polyether (IV), i.e. alpha,omega-dihydroxy-poly(oxytetramethylene) or -poly(oxyethylene) or copolymer of ethylene glycol and propylene glycol, with di-isocyanate, diacid halide or phosgene. Also claimed are (1) medical implants made from (I), pref. in the form of tubes with one or more channels, or with a porous structure, esp. for the prodn. of simple and composite biological fabric, which may also contain particulate pharmaceuticals or diagnostic prods., (2) surgical accessories made from (I), intended for use in and on the body, (3) dihydroxy-polyesters (II) with a controlled random or block microstructure, obtd. by ring-opening polymerisation of a mixt. of at least two of the cpds. (L,L)-, (D,D)- or (D,L)-dilactide, diglycolide, beta-(R)-, beta-(S)- or beta-rac-butyrolactone or epsilon-caprolactone in presence of an aliphatic diol, or by transesterification as above.
Patent AT-E191710-T1 (AT)
Inventor: LANTZSCH REINHARD DR
IPC: B01J25/02
Filed: 1995-08-01
Granted: 2000-04-15
Abstract: Prodn. of 2-amino-2-arylethanols of formula Ar-CH(NH2)-CH2OH (I) comprises catalytically hydrogenating a 2-hydroxy-1-aryl-ethanone oxime of formula Ar-C(=NOH)-CH2OH (II) using a Raney nickel or cobalt catalyst in a diluent and in the presence of a base. Ar = aryl or heteroaryl opt. mono- to penta-substd. by halo, alkyl or alkoxy (opt. substd. by halo), or opt. substd. cycloalkyloxy or phenyl.
Patent AT-E192995-T1 (AT)
Inventor: LOIODICE ALDO
IPC: B66B7/02
Filed: 1995-06-03
Granted: 2000-06-15
Abstract: A lift system wherein lift-car guides and/or counter-weight guides, both placed at a single plain, provide a self load bearing, modular supporting frame with its loads discharged directly into the pit. Further, the proper positioning of the driving members allows an optimum use of both the space inside the lift well and outside it. An arrangement for mounting the main motor in electric lift systems in which the motor is connected to a shelf in turn transversely fixed to at least one of the two pairs of guides by shaped sheets. Using such an arrangement it is possible to place the motor anywhere along the lift-car well. <IMAGE>
Patent AT-E160988-T1 (AT)
Inventor: ANNIS JAMES R JR
IPC: B65B13/22
Filed: 1995-02-24
Granted: 1997-12-15
Abstract: A method and apparatus for a two speed strap take up usable in a strapping machine. The two speed strap take up apparatus generally comprises a high speed roller assembly (20) driven by a high speed drive shaft (28), a low speed roller assembly (40) driven by a low speed drive shaft (48), a shaft rotation reduction assembly (56) interconnecting the high speed drive shaft (28) and the low speed drive shaft (48), and a roller clutch assembly (220) inter-connecting the shaft rotation reduction assembly (56) and the low speed drive shaft (48). An input clutch assembly (250) may inter-connect the high speed drive shaft (28) and an input drive means. In operation, a strap (12) is disposed between and frictionally engaged by a high speed roller (22) of the high speed roller assembly (20) and a low speed roller (42) of the low speed roller assembly (40). The low speed roller (42) is then driven in rotation by the high speed roller (22). When a first tension is applied to the strap (12), the high speed roller (22) slips relative to the high speed drive shaft (28) until the roller clutch (220) inter-connecting the shaft rotation reduction assembly (56) and the low speed drive shaft (48) engages and rotates the low speed drive shaft (48) at a reduced rotation rate relative to the rotation rate of the high speed drive shaft (28). The strap (12) is now driven by both rollers (22, 42) at the reduced rotation rate as the high speed roller (22) slips relative to the high speed drive shaft (28). When a second tension, greater than the first tension, is applied to the strap (12), the low speed roller (42) slips relative to the low speed drive shaft (48) at which time the strapping machine may perform additional functions on the strap (12) such as securing it around a package. <IMAGE>
Patent AT-E182884-T1 (AT)
Inventor: UENO RYUJI
IPC: A61K31/5575
Filed: 1995-05-31
Granted: 1999-08-15
Abstract: The object of the present invention is to provide a pharmaceutical composition for treatment of hepato.biliary disease reduced in side effect such as diarrhea, which comprises 16,16-difluoro-15-keto-PGs having at least one methyl group or ethyl group on the carbon atom at the 17- or 18-position or adjacent to the terminal methyl group of omega -chain as an essential component.
Patent AT-E169607-T1 (AT)
Inventor: DUGAT JEROME
IPC: E04C5/01
Filed: 1995-03-13
Granted: 1998-08-15
Abstract: The material for injection to shroud a framework, and especially prestressed cables, is composed of 1.3-3.0 wt.% of inert hydrophilic particles in the cement mixture. They have a specific surface of more than 200 m<2>/g, to give a fraction during mixing and/or injection into numerous fragments as small as 5 nanometres and as large as 300 nanometres. The particles are of precipitated silica.
Patent AT-E226504-T1 (AT)
Inventor: LAVER TERRY C
IPC: B27N3/04
Filed: 1994-11-10
Granted: 2002-11-15
Abstract: An apparatus and process for combining an organic fibrous material with a thermoplastic material forming a wood-imitating composite. The mixed material is extruded into a die system comprising a transition die, a stranding die and a molding die. The flow rate of the material through the die system is equalized by preforming the mixed material with the transition die to a shape approaching the end product, stranding the material with the stranding die to form individual strands, and compressing the individual strands with the molding die after it exits the stranding die. The die system may also include an adapter die positioned between the extruder and the transition die which functions to control the amount of mixed material which enters the die system. A product comprised of recyclables shredded and mixed to form a wood-imitating composite from a low-temperature extruder is also provided.
Patent AT-E166907-T1 (AT)
Inventor: CORAN AUBERT YAUCHER
IPC: C08K5/17
Filed: 1995-01-17
Granted: 1998-06-15
Abstract: Vulcanizable rubber compositions are disclosed which contain co-activator of vulcanization which is a polymeric amine, that is, a hydrocarbon polymer with pendent alkyl amine groups. The co-activators impart increased rates of vulcanization with little decrease in scorch delay and very little increase in the modulus of the cured compositions. No increase in heat build-up or decrease in flex-fatigue life is shown. Typical polymers forming the backbone of the co-activators include EPDM rubber and polymers from butadiene or isoprene, with optional co-monomers.
Patent AT-E191660-T1 (AT)
Inventor: TOSCHI ANGELO
IPC: B02C13/286
Filed: 1995-08-31
Granted: 2000-04-15
Abstract: PCT No. PCT/IB95/00719 Sec. 371 Date Mar. 5, 1997 Sec. 102(e) Date Mar. 5, 1997 PCT Filed Aug. 31, 1995 PCT Pub. No. WO96/07481 PCT Pub. Date Mar. 14, 1996A method and a mill (1) or crushing station (A) for crushing rubble, wherein the crushed material fills the mill discharging hopper (9) for a height (H1) which is higher than the height (H) of a hopper discharging opening (11) so that a continuous material plug (6) is formed which closes said discharging opening (11). The discharging means (2; 17) can be either integrated into the mill discharging hopper (9) or form a separated discharging device (2) which is associated to the mill (1). In operation the plug (6) is continuously removed from the plug bottom and fed to the plug top so that said continuous plug prevents the formation and exhausting of dust. The known dust separation chambers are thus superfluous.
Patent AT-E175560-T1 (AT)
Inventor: BRAZEAU PAUL
IPC: A61B17/08
Filed: 1995-09-15
Granted: 1999-01-15
Abstract: The present invention relates to a device for closing cutaneous wounds without sutures, which comprises a pair of three-dimensionally flexible strips adopted to be positioned on each side of a wound and formed of a plurality of laterally spaced apart elongated anchoring members extending side-by-side in succession and transversely of the wound and being interconnected in a three-dimensionally flexible manner to follow the lips of an open wound. Each of the anchoring members has on the underside thereof an adhesive surface for adhesion directly of indirectly to the skin of a patient, and includes at an inner end thereof a thread receiving and retaining portion, whereby a thread can be engaged lace-wise through the anchoring members of both strips so as to draw the anchoring members of one strip towards the anchoring members of the other strip in such a way so as to close in a constant tensiometric way the open wound extending between the two strips with the lips of the wound being equidistant along the entire length thereof.
Patent AT-E164085-T1 (AT)
Inventor: TELLER JOACHIM DR
IPC: A61F2/00
Filed: 1995-09-06
Granted: 1998-04-15
Abstract: PCT No. PCT/EP95/03499 Sec. 371 Date Mar. 7, 1997 Sec. 102(e) Date Mar. 7, 1997 PCT Filed Sep. 6, 1995 PCT Pub. No. WO96/07438 PCT Pub. Date Mar. 14, 1996The invention concerns a method for the electrochemical deposition of hydroxyapatite layers onto metal and ceramic surfaces, the actual electrochemical coating being combined with a pre-coating of the substrates by sol-gel processes, using a calcium and (hydrogen) phosphate-containing electrolyte by means of pulsed direct current. Materials coated in this way are used in the form of biocompatible implants in human and veterinary medicine and are distinguished by particularly high grow-in rates. In contrast to conventional methods of generating hydroxyapatite layers (conventional or microwave sintering of hydroxyapatite produced by the wet-chemical method, deposition by other electrochemical, plasma or laser-aided methods or by sol-gel techniques), this method is distinguished by the application of uniform hydroxyapatite coatings which adhere well and have a small amorphous portion and an optimum layer thickness (5-25  mu m) whilst requiring comparatively low expenditure in terms of apparatus, energy, time and material.
Patent AT-E190261-T1 (AT)
Inventor: ECKARDT HELMUT
IPC: B29C45/17
Filed: 1996-06-19
Granted: 2000-03-15
Abstract: A process for prodn. of plastic products with hollow chambers comprises: (a) injecting plastic melt into a mould cavity (2); (b) simultaneously and/or subsequently injecting a pressurised fluid, esp. a gas, into the melt with a nozzle (7) to create a hollow chamber; (c) cooling the moulding (6) to below the polymer m.pt.; (d) releasing fluid pressure from the cavity (2) and demoulding the prod. (6). During and/or after the injection of pressurised fluid the vol. of an overflow cavity (8) connected to the mould cavity (2) is increased, allowing some polymer to be forced into the overflow cavity (8) by fluid pressure. Process appts.. comprises an injection unit (4,5) with nozzle (7) for injecting pressurised fluid, a two or more part tool (1) with one or more overflow cavities (8) connected to the mould cavity (2) and a mechanism (9) for varying overflow cavity(8) volume. Pref. overflow cavity (8) vol. change is controlled according to the time from the start of cavity filling and/or to cavity pressure. The connecting channel between the mould (2) and overflow (8) cavities is heated to maintain constant melt fluidity between them. Prior to cooling the injected polymer the overflow channel (8) is reduced in size to force polymer back into the mould cavity (2) and close the opening between the cavities (2,8) to prevent polymer re-entering the overflow cavity (8). A piston and cylinder unit (9) forms the overflow cavity (8) and the mechanism (9) for varying the volume of this cavity (8). Heaters (10) are located between the mould (2) and overflow (8) cavities.
Patent AT-E212632-T1 (AT)
Inventor: SHIH CHUAN
IPC: A61K31/505
Filed: 1996-09-04
Granted: 2002-02-15
Abstract: 2-Amino-4-hydroxy-4,5,6,7-tetrahydropyridoÄ2,3-dÜpyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-ä4-Ä2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyridoÄ2,3-dÜpyrimidin -6-yl)ethylÜbenzoylü-L- gamma -glutamyl)-D-aspartic acid.
Patent AT-E200622-T1 (AT)
Inventor: ENDOU HITOSHI
IPC: A61K31/4166
Filed: 1996-12-20
Granted: 2001-05-15
Abstract: The present invention is directed to a pharmaceutical composition comprising a hydantoin derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof <CHEM> wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group, and a pharmaceutically acceptable carrier or diluent. The above mentioned hydantoin derivative has an action of eliminating the active oxygen and the free radicals. Accordingly, it is useful for preparing a pharmaceutical agent for treating a variety of diseases in which active oxygen and free radicals are participated such as myocardial infarction, reperfusion disturbance, autoimmune diseases, fibrosis, pulmonary diseases, dermatological diseases, arthropathy, side effects of anticancer agents, radiation diseases, septic shock, inflammatory diseases and cataract.
Patent AT-E216709-T1 (AT)
Inventor: SAEKI TOSHIAKI
IPC: C07K16/40
Filed: 1996-02-07
Granted: 2002-05-15
Abstract: A monoclonal antibody is described. The monoclonal antibody is specifically reactive with a ribonucleotide reductase R2 subunit and inhibits ribonucleotide reductase activity. In a preferred aspect, an anti-ribonucleotide reductase (RNR) R2 subunit monoclonal antibody KM1054, KM1056 or KM1060, which belongs to the IgG2a subclass, reacts with R2 subunit of RNR, and inhibits RNR activity, is disclosed. The antibody is effective for immunologically detecting RNR and for immunologically detecting the presence of human cancer cells.
Patent AT-E228819-T1 (AT)
Inventor: VAN DEN BOSCH WILLEM FREDERIK
IPC: A61K9/06
Filed: 1996-02-23
Granted: 2002-12-15
Abstract: PCT No. PCT/NL96/00091 Sec. 371 Date Sep. 5, 1997 Sec. 102(e) Date Sep. 5, 1997 PCT Filed Feb. 23, 1996 PCT Pub. No. WO96/25916 PCT Pub. Date Aug. 29, 1996The present invention relates to a method for preparing a preparation for bleaching teeth or for treating skin complaints and mucous membrane disorders, in which method at least the following are combined: (a) a gel or paste in which a component (i) is present, component (i) being composed of at least a cation An+ and an anion OmX-; where A is a metal from Group 1 or 2 of the periodic system, n=1 or 2, X is a halogen atom and m=1-4, and (b) a gel or paste in which a component (ii) is present, component (ii) being composed of at least a cation An+ and an anion [BpOq]r-, where A is a metal from Group 1 or 2 of the periodic system, p=1-4, q=1-8 and r=1-3.
Patent AT-E186845-T1 (AT)
Inventor: PEIPER URI
IPC: A61L2/00
Filed: 1996-08-27
Granted: 1999-12-15
Abstract: PCT No. PCT/IL96/00090 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Aug. 27, 1996 PCT Pub. No. WO97/09071 PCT Pub. Date Mar. 13, 1997The present invention provides a method for sterilization of objects including the steps of placing the object that should be sterilized in a closed vessel; placing the closed vessel between two high voltage electrodes; applying a high voltage between the electrodes and converting the oxygen in the air inside the closed vessel into ozone; and keeping the sterilized object inside the closed vessel as long as needed. A "closed vessel" includes also any form of closed container or any closed plastic bag. The closed vessel may or may not have internal electric conductors. Furthermore, the invention provides a device for ozone sterilization of objects for use in the method. The device for sterilization comprises a sterilization chamber; two parallel high voltage electrodes located inside the chamber and connected to a high voltage transformer; a closed vessel with or without internal electrodes located between the two high voltage electrodes and the object to be sterilized is placed inside the vessel; and two parallel insulators located between the two high voltage electrodes and the closed vessel.
Patent AT-E205382-T1 (AT)
Inventor: MANE JEAN
IPC: A23G3/34
Filed: 1996-08-29
Granted: 2001-09-15
Abstract: The invention relates to refreshing compositions, flavouring compositions and ingestible and topical compositions containing at least a refreshing compound selected amongst monomenthyl succinate, alcaline metal salts of monomenthyl succinate, alcaline-earth metal salts of monomenthyl succinate and mixtures thereof. Said compositions provide a durable, bitterness-free, pleasant and refreshing effect, and said refreshing feel is different from that of other known refreshing agents. Consequently, a complementary or synergic effect can be obtained by combination with other refreshing agents. Furthermore, the succinate-based refreshing compounds according to the invention provide for an increase of alcohol feel in alcoholic drinks. Finally, the succinate-based refreshing compounds provide a refreshing taste when they are applied to filters, combustible papers and sheets for wrapping tobacco products for smoking and when they are incorporated into tobacco products for chewing or snuffing.