baber/WOPTO huggingface dataset:
Patent BR-PI1006104-B1 (BR)
Title: gene isolado que codifica glucoquinase humana, vetor recombinante, hospedeiro, e, composição farmacêutica
Inventor: HAIDONG HUANG
IPC: C12N15/54
Filed: 2010-01-06
Abstract: GENE QUE CODIFICA GLUCOQUINASE HUMANA MUTANTE, GLUCOQUINASE HUMANA MUTANTE, VETOR RECOMBINANTE, HOSPEDEIRO, COMPOSIÇÃO FARMACÊUTICA, USO DE UM GENE, DE UMA GLUCOQUINASE HUMANA MUTANTE, DE UM VETOR RECOMBINANTE, DE UM HOSPEDEIRO E DE UMA COMPOSIÇÃO FARMACÊUTICA O gene que codifica a glucoquinase humana mutante é fornecido. O gene tem a sequência de nucleotídeo escolhida da sequência de nucleotídeo listada como SEQ ID NO: 2 e a sequência de nucleotídeo em que a região da ORF codifica a mesma sequência de aminoácido como aquela codificada pela região da ORF (posição 487 a 1884) da SEQ ID NO: 2 e a região restante é a mesma como a região que não da ORF da SEQ ID NO: 2. A glucoquinase humana mutante codificada pelo gene, os vetores recombinantes que carregam o gene, os hospedeiros que compreendem os vetores, composições farmacêuticas destes, seu uso, e métodos para tratar e prevenir doenças pelo uso do mesmo são fornecidos. A glucoquinase humana mutante codificada pelo gene tem atividade mais alta do que aquela da glucoquinase humana do tipo selvagem, e assim fornece um novo modo de controlar a glicose sanguínea ou prevenir e tratar distúrbios do metabolismo de carboidrato, especialmente prevenir e tratar a diabete.
Patent BR-PI1012151-B1 (BR)
Title: conjunto de trituramento para uso subterrâneo para triturar e recuperar um objeto sendo triturado
Inventor: STEVEN G BLAIR
IPC: E21B37/00
Filed: 2010-05-14
Abstract: conjunto de trituramento para uso subterrâneo para triturar e recuperar um objeto sendo triturado a presente invenção refere-se a um triturador que é configurada para ter grandes passagens de detritos dispostas entre uma série de lâminas que se estendem radialmente. o centro do triturador é adaptado para aceitar uma porca de retenção que suporta uma ferramenta que prende a ferramenta no fundo do poço sendo triturada, tal como um packer. o fluxo inverso leva os fragmentos para dentro da área grande, aberta entre as lâminas para subir em um espaço anular ao redor de um suporte para a porca de retenção. a passagem, então, se abre para uma dimensão máxima, deixando somente a parede do tubular necessária para a resistência estrutural para suportar o triturador e conduzir os fragmentos para dentro de uma ferramenta de remoção de detritos.
Patent BR-PI1014279-B1 (BR)
Title: Uma nova formulação de meloxicam
Inventor: AARON DODD
IPC: A61P29/00
Filed: 2010-04-23
Abstract: uma nova formulação de meloxicam a presente invenção se refere a métodos para produzir partículas de meloxicam usando processos de moagem a seco bem como as composições compreendendo meloxicam, medicamentos produzidos usando meloxicam em forma de partículas e/ou composições, e a métodos de tratamento de um animal, incluindo humanos, usando uma quantidade terapeuticamente eficaz de meloxicam administrada por meio de ditos medicamentos.
Patent EA-001046-B1 (EA)
Title: Process for the crystallization of losartan
Inventor: BREEN PATRICK
IPC: C07D403/10
Filed: 1997-10-24
Abstract: 1. A process for the crystallization of losartan potassium comprising the steps of: a) distilling an isopropanol-water mixture containing losartan potassium to about 2.4 to about 2.8% water content; b) cooling the mixture to between about 65 degree  and about 70 degree C; c) adding about a.5% by weight finely-milled losartan potassium in cyclohexane slurry at between about 60 degree  and about 65 degree C at a rate of about 0.3 1/min. to the vessel until the cloud point is reached at about 1.8 to about 2.3% water content; d) aging the mixture for about ten minutes; e) adding about 3 to about 10% by weight finely-milled losartan potassium to seed the mixture at a temperature range of about 60 degree C to about 70 degree C; f) aging the seeded mixture for about 1 to about 2 hours at a temperature range of about 60 degree C to reflux while stirring; g) adding about a 60-65 degree C solution of cyclohexane over about a two hour period maintaining a temperature of about 68 degree C for the mixture; h) distilling the mixture at a constant volume to a water content of about 0.5%, while maintaining the constant volume by addition of between about a 50:50 and a 80:20 volume to volume ratio of cyclohexane and isopropanol; i) distilling the mixture to a slurry density of about 200 g/1 and a water content of about less than 0.1%, while adding cyclohexane to maintain about a volume to volume ratio of between about a 50:50 to about a 60:40 cyclohexane:isopropanol, if necessary; j) cooling the mixture to between about 20 degree C and about 30 degree C; k) filtering the mixture to isolate the crystalline losartan potassium; 1) washing the crystalline material with 75:25 cyclohexane:isopropanol; m) washing the crystalline material with cyclohexane; and n) drying the crystalline losartan potassium under vacuum at a temperature of about 45 degree  to about 50 degree C. 2. The process as recited in claim 1, wherein about 3 to about 8% by weight finely-milled losartan potassiumis added. 3. The process as recited in claim 2 wherein the the isopropanol-water distillation step is run until about 2.6 to about 2.8% water content is reached. 4. The process as recited in claim 3 wherein the cyclohexane-losartan potassium slurry until the cloud point is reached at about 1.8 to about 2.0% water content. 5. The process as recited in claim 4 wherein the temperature during the seed step is about 65 degree  to about 70 degree C. 6. The process as recited in claim 5 wherein the constant volume distillation is conducted until the water content is about 0.5%. 7. The process as recited in claim 6 wherein about 5% by weight finely-milled losartan potassium is added. 8. The process as recited in claim 7 wherein the particle size of the finely-milled losartan potassium is about 8 to about 10 μm.
Patent EA-002788-B1 (EA)
Title: Ski pole handle device
Inventor: VOLD PER ERIK
IPC: A63C11/22
Filed: 2000-01-12
Abstract: 1. A ski pole handle device comprising an external liner material fastened to an elongated handle stem which comprises an upper head (1) for attachment of a strap and which is adapted to the internal shape of the liner material, characterized in that the stem mainly covers only the in the use-position forward and rearward portion along the gripping area of the handle, whereby the stem along the gripping area of the handle comprises two elongated portions (3,4) having internal surfaces adapted to the shape of the pole, and whereby two longitudinal openings in the stem are defined between these portions (3,4). 2. A device as defined in Claim 1, characterized in that the elongated portions (3,4) have an approximately sickle shaped cross section. 3. A device as defined in Claim 1 or 2, characterized in that the liner material is formed by cork granules formed by pressing and glueing together. 4. A device as defined in one of the Claims 1-3, characterized in that the stem comprises an external rib (9) along the middle plane of at least one of the elongated portions (3,4).
Patent EA-003588-B1 (EA)
Title: Safety packing for a product to be exhibited
Inventor: AARTS MATHIEU
IPC: B65D85/57
Filed: 2001-01-30
Abstract: 1. A safety packing for a product to be exhibited, for example, a CD packing, comprising a housing for keeping the product, with an opening for inserting or removing the product and a locking mechanism comprising a frame part which is securely connected with the housing and a locking element to be moved between two positions, namely a locking position where the product may be prevented from being moved into and from the housing, and an open position where the product may be moved into and from the housing, wherein the locking element is pushed through a spring in the direction of the open position, and a retainer which is movable between a retaining position and a release position, which retainer is pushed in the retaining position through a spring, wherein the retainer in the retaining position secures the locking element when this latter is in the locking position relative to the frame part, which retainer can be moved against the spring load through a magnetic force towards the release position in order to let the locking element move freely, characterized in that the locking mechanism is provided with an opening and the retainer can therefore only be shifted from the retaining position to the release position in such a way that this may only occur using a magnetic force generated by a magnet or a magnetized element located in the opening. 2. A packing according to claim 1, characterized in that the opening and the magnet or magnetized element to be inserted therein have a mutually adapted shape. 3. A packing according to claim 1 or 2, wherein the locking element is movable in a first direction, characterized in that the retainer is formed by at least a pin which can be moved in one direction which is essentially perpendicular to the first direction. 4. A packing according to claim 3, characterized in that the pin cooperates with one an opening in the frame part, wherein the magnetic force is insufficient to draw the pin out of the opening as a result of the frictional force between pin and opening generated by the spring acting on the locking element and that a mechanical shift of the locking element is required so as to eliminate this frictional force. 5. A packing according to claim 4, characterized in that an opening is provided in the locking mechanism in which a pin can be stuck so as to generate the mechanical shift. 6. A packing according to claim 5, characterized in that the pin and the opening have a profile mutually adapted to each other.
Patent EA-004774-B1 (EA)
Title: Method of protecting information on paper medium "atlas-crystal"
Inventor: BOGDANOV VLADIMIR NIKOLAEVICH
IPC: G07D7/00
Filed: 2003-02-10
Abstract: 1. The method of protecting information on the paper medium, characterized in that control information in the digital form is signed using the electronic digital signature, then the information obtained is converted from the digital form into a bar code which is applied to the document; when reading, the bar code is converted into a digital form; the electronic digital signature and control information are singled out; the authenticity of electronic digital signature is verified; if the electronic digital signature is genuine, then the control information from the bar code is visually compared with the information contained in the document; by results of comparison the conclusion is made as to authenticity of information inscribed on the document; all the information in the document is used as control information or a portion of the information which represents N of non-replicated fragments where N=1,2,3, ..., wherein the bar code with control information is considered as the primary bar code; the form account number is converted into an auxiliary bar code which is applied to the form; the auxiliary bar code is read and converted into a digital form, with additional inclusion in the control information of account number form, unique registration number of key signature certificate and name of the body that issued the key signature certificate; in addition to that, when reading the primary bar code, we single out the unique registration number of signature key certificate and name of the body that issued the key signature certificate; we identify the open key of electronic digital signature which is used for verification of authenticity of electronic digital signature. 2. The method of claim 1, wherein test fragments or fragments of images in the form of drawings, logotypes, trademarks are used as N of non-replicated fragments where N=1,2,3, ...,. 3. The method of claim 1 or 2, wherein the linear bar code is used as an auxiliary bar code.
Patent EA-007599-B1 (EA)
Title: Pharmaceutical compositions comprising one or more steroids one or more tetrahydropolate components and vitamin b
Inventor: COELINGH BENNINK HERMAN JAN TIJMEN
IPC: A61P15/12
Filed: 2002-11-15
Abstract: The present invention is concerned with a kit for use in a hormonal contraceptive method or hormone replacement therapy in mammalian females, said kit comprising at least 10 oral dosage units containing at least 1 microgram of one or more steroids selected from the group consisting of estrogens and progestogens; at least 0.1 mg of one or more tetrahydrofolate components selected from the group consisting of (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5 formimino-(6S)-tetrahydrofolic acid, pharmaceutically acceptable salts of these tetrahydrofolic acids and glutamyl derivatives of these tetrahydrofolic acids; and at least 0.1 mg vitamin B. Other aspects of the present invention relate to a hormonal contraceptive method and a method of hormone replacement therapy comprising the at least once daily oral administration of one or more steroid containing dosage units to a mammalian female, wherein the dosage units additionally contain at least 0.1 mg of one or more of the aforementioned tetrahydrofolate components and at least 0.1 mg vitamin B.
Patent EA-006513-B1 (EA)
Title: Gas burner
Inventor: DUBROVIN NIKOLAY FEDOROVICH
IPC: F23D14/06
Filed: 2004-11-10
Abstract: The invention is directed to increase the coefficient of pressure recovery in the Venturi tube to improve mixture-forming at low height of the burner. The said technical result is achieved by that the gas burner comprises a support with an injector for gas inlet and arranged between the upper and lower surfaces of a cooking range. The gas burner comprises a flame spreader in the form of the Venturi tube having a confuser portion, a neck and an upper profiled surface and mounted on the support co-axially with the injector for gas supply. A cap is above the flame spreader, its bottom surface forms a horizontal diffusion portion with the upper profiled surface of the flame spreader. There further provided a conic axial diffusion portion in the flame spreader above the neck, the diffusion portion transforming into the horizontal diffusion portion along the radius surface, wherein its length does not exceed 1/3 of the Venturi tube confuser portion length, and the neck is arranged in the axial aperture of the Venturi tube. The conic axial diffusion portion of the flame spreader can be made with a cone angle of 6-10 degree . An aperture can be made in the support cylindrical portion. Small size of a gas burner makes it possible to use it in built-in cooking panels, which is getting more popular at present.
Patent EA-008328-B1 (EA)
Title: Game machine
Inventor: KUKITA NORITOSHI
IPC: G07F17/32
Filed: 2004-12-24
Abstract: The game machine is provided with a cabinet having a cabinet frame inside, an oscillation frame rockably supporting the cabinet, an oscillator for oscillating the cabinet, a mounting base which is fixed on the cabinet frame with the grounding surface covering almost the entire area of at least one side, a lottery panel which is disposed above the mounting base and has a plurality of lottery holes adapted to let the lottery balls enter, a detector which is mounted on the mounting base and detects the entry of the lottery balls into the lottery holes and a post which is extended upward from the position of the lottery panel and electrically connected to the cabinet frame and the grounding surface.
Patent EA-013694-B1 (EA)
Title: Method and apparatus and program storage device including an integrated well planning workflow control system
Inventor: GURPINAR OMER
IPC: G06F/
Filed: 2004-06-24
Abstract: A Single Well Predictive Model (SWPM) software based computer system stores SWPM software therein that, when executed (1) automatically produces a first specific workflow comprised of a first plurality of software modules in response to a first set of user objectives and executes the first specific workflow in response to a first set of input data to produce a first desired product, and (2) automatically produces a second specific workflow comprised of a second plurality of software modules in response to a second set of user objectives and executes the second specific workflow in response to a second set of input data to produce a second desired product. A method of well planning utilizing the SWPM software involves the steps of. selecting one or more tasks in a task manager; verifying by a task dependency a proper order of the one or more tasks; retrieving by the task manager from a task base one or more sets of instructions associated with the one or more tasks selected in the task manager and verified by the task dependency; retrieving by the task manager from an access manager one or more sets of input data associated with the one or more sets of instructions retrieved by the task manager from the task base; verifying that each set of input data of the one or more sets of input data retrieved by the task manager from the access manager is received by a corresponding one of the one or more sets of instructions retrieved by the task manager from the task base; executing, by the task manager, the one or more sets of instructions and using, by the task manager, the one or more sets of input data during the executing step thereby generating a set of results; and recording or displaying, by a task view base, the set of results on a recorder or display device.
Patent EA-009457-B1 (EA)
Title: Benzimidazolone compounds having 5-ht, receptor agonistic activity
Inventor: IGUCHI SATORU
IPC: C07D471/04
Filed: 2004-08-20
Abstract: This invention provides a compound of the formula (I)or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HTreceptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
Patent EA-008185-B1 (EA)
Title: Method for performing off financial transaction (variants)
Inventor: SHUVAEV LEONID ALEXEEVICH
IPC: G06Q30/00
Filed: 2006-01-23
Abstract: An invention proposes a method of performing payoff financial transaction comprising charge-off a payment sum from the remitter's account and transfer said sum to the remittee, identification of both the remitter and remittee in the center for processing the transaction data and forming a payment document certifying performing the financial transaction and comprising at least an identifier of the financial transaction and said sum. A distinctive feature of the invention is characterized in that the method comprises pre-blocking a payment sum in the amount equal or greater of the charged-off sum at the remitter' account during pre-set period of time, wherein the remitter transmits, using a wireless communication, command for blocking said payment sum to the center of financial transaction's processing, which performs the charge-off the sum before the expire of the pre-set period of time.
Patent EA-019384-B1 (EA)
Title: Method of well treatment and construction
Inventor: GODOEY RUNE
IPC: C04B28/02
Filed: 2006-04-26
Abstract: The invention provides a method of well construction or treatment which comprises introducing a setable cement composition down a borehole, characterized in that said composition contains pulverulent aplite in the amount of at least 100 weight parts to 100 weight parts of cement on a dry solids basis.
Patent EA-010845-B1 (EA)
Title: Annular packer device
Inventor: FREYER RUNE
IPC: E21B/
Filed: 2006-04-28
Abstract: An annular packer device (1), wherein the annular packer (1) is expandable in an annulus (6) between an inner body (8) and an outer boundary (12), and wherein the annular packer (1) is sealingly movable along at least one of the inner body (8) and the outer boundary (12).
Patent EA-016463-B1 (EA)
Title: Device for purification of sewage from petroleum products
IPC: E03F5/16
Filed: 2008-09-10
Abstract: The invention relates to sewage purification technology and can be used for purification of rainfall sewage from petroleum products and discharged industrial wastes. The inventive task is directed at production of high quality compact equipment for sewage purification from petroleum products. The invention is aimed at increasing rate of liquid purification and decreasing overall size of the device. The device for sewage purification from petroleum products comprises a angle capacity separated by partitions to chambers, branch pipes connecting chambers by the power reservoir system, a discharging U-shaped pipeline arranged in one chamber and provided with a breath tube at an upper part of a bend. A pipeline inlet is arranged inside a hollow cylinder serving as a partition, wherein the outlet is connected through branch pipes and a funnel with an expander arranged vertically in another chamber and provided with a protective branch pipe, the upper edge of which is positioned higher the level of the U-shaped pipeline bend. Wherein the U-shaped pipeline is developed in plan at α angle relative to the branch pipes. In some cases U-shaped pipeline can be mounted either left or right development in plane at α angle relative to the branch pipes.
Patent EA-016791-B1 (EA)
Title: Substituted 8-[6-amino-3-pyridyl]xanthines
Inventor: WANG GUOQUAN
IPC: A61K31/497
Filed: 2007-06-13
Abstract: The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of Aadenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
Patent EA-016229-B1 (EA)
Title: Method to conserve and/or the antioxidant activity of dark chocolate for conching thereof (embodiments) and products obtainable by the method
Inventor: BEHEYDT BRAM
IPC: A23G1/14
Filed: 2007-08-16
Abstract: The present invention relates to a novel method for conching chocolate, whereby a chocolate mass is submitted to a conching method that comprises the following steps: - a dry conching step performed at a temperature of between 50°C and 70°C, - and subsequent a wet conching step performed at a temperature of between 60°C and 90°C, wherein the dry and the wet conching temperatures are comprised within the range(s) defined by the graph of figure 13 and in tables in the invention claims, wherein the dry conching step lasts for 6 hours to about 12 hours and the wet conching step lasts for at least 3 hours. Advantageously, this adapted conching process conserves and even increases the antioxidant activity of a chocolate, in particular a dark chocolate. Consequently, the present invention further relates to a method of conserving and even increasing the antioxidant activity of chocolate.