baber/WOPTO huggingface dataset:
Patent PT-2102331-E (PT)
Title: Anti-tumor vaccine derived from normal chemically modified cd4+ cells
Inventor: KIRKIN ALEXEI
IPC: C12N5/0783
Filed: 2008-01-03
Abstract: A composition for inducing an immune response in a mammal, comprises lymphoid cells in which expression of tumor antigens has been chemically induced. The tumor antigens are induced in proliferating normal lymphoid cells, especially during the log phase of proliferation. The proliferation of the normal lymphoid cells is stimulated by normal mature dendritic cells. Most conveniently, the lymphoid cells are lymphocytes, especially peripheral blood lymphocytes. The tumor antigens are typically cancer/testis antigens, which may be chemically induced by DNA demethylation. Cancer/testis antigens are expressed in a wide range of tumors, so the composition is able to raise an immune response that is effective against a wide range of tumors, despite the fact that it is derived from normal cells. The composition may be used for preparation of an anti-tumor vaccine for prophylactic or therapeutic use. The composition may also be used for ex vivo activation of cytotoxic T lymphocytes, followed by expansion of the cytotoxic T lymphocyte population by normal dendritic cells, for cancer treatment by adoptive T cell immunotherapy.
Patent PT-2321116-E (PT)
Title: Method and apparatus for manufacture of a polymer film, which is oriented under an angle to its longitudinal direction
Inventor: RASMUSSEN NIKOLAJ WETTERGREN
IPC: B29C55/06
Filed: 2009-07-22
Abstract: Flexible tubular film (10) is helically cut into a flat strip by unwinding the tubular film in flattened form by a tumbling unwinder (1), advancing the flat film tube to a tube expansion zone (17) in which the flat tube is expanded into a circular cylindrical tube and is passed axially over a hollow mandrel (14) slightly lower in external diameter than the diameter of the expanded tube to be cut by knife (18) helically while on the mandrel into a flat strip that is removed at an angle to the mandrel axis. The flat tube is longitudinally stretched by stretching rollers (107-112), which tumble with the tumbling unwinder. The apparatus further comprises stabilization means for stabilizing the orientation applied by the tumbling stretching rollers, applied to the helically cut film strip after it has been drawn from the mandrel.
Patent PT-2383271-E (PT)
Title: Aminoquinolones as gsk-3 inhibitors
Inventor: COCIORVA OANA
IPC: A61K31/553
Filed: 2007-03-13
Abstract: Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.
Patent PT-574345-E (PT)
Inventor: NUNO BARBOSA NOLASCO
IPC: C12Q1/6804
Filed: 1993-06-10
Abstract: Based on the immobilisation of the pathogen by using antibodies attached to the inner surface of the cups of a microtitration plate, with subsequent synthesis, on the same plate, of the complementary DNA with a fragment of the genom of viral or subviral pathogens and subsequent enzymatic amplification on the same plate, then proceeding to quantify the products of amplification by using spectrophotometric techniques, also carried out on the same plate, and finally, the identification of the products of amplification by means of electrophoretic techniques. <IMAGE>
Patent PT-800384-E (PT)
Inventor: MCCARTHY PAUL
IPC: A61K31/4045
Filed: 1995-12-14
Abstract: A direct compression pharmaceutical tablet formulation comprising: an active pharmaceutical ingredient; a direct compression excipient which interacts with the active pharmaceutical ingredient; and an amount of an inhibitor to reduce the interaction between the direct compression excipient and the active pharmaceutical ingredient.
Patent PT-853591-E (PT)
Inventor: DUIJNSTEE EDUARD JOZEF MARIE
IPC: B66B9/08
Filed: 1996-10-02
Abstract: PCT No. PCT/NL96/00382 Sec. 371 Date Jul. 2, 1998 Sec. 102(e) Date Jul. 2, 1998 PCT Filed Oct. 2, 1996 PCT Pub. No. WO97/12830 PCT Pub. Date Apr. 10, 1997A running gear (3), for a drive mechanism of a rail-guided displacement device, such as a passenger lift, comprising a base part, a drive and at least two sets of guide wheels (9), arranged behind each other, viewed in direction of travel of the running gear, so that, during use, the running gear is guided along the rail in a desired position by the guide wheels, the base part comprising at least a bridge piece (5), a first and a second frame part (6, 7), the frame parts each being connected to the bridge piece so as to be movable about at least one pivotal axis, each frame part carrying a set of guide wheels and the frame parts being mutually coupled by coupling means which form a mechanical mirror, so that the movements of the first and the second part are always each other's mirror image in a first plane of symmetry extending at right angles to the driving direction of the running gear between the first and the second frame part, and viewed relative to the bridge piece.
Patent PT-816344-E (PT)
Inventor: GERHARD STUCKY DR
IPC: A61K31/70
Filed: 1995-04-25
Abstract: Production of 2,5-diamino-4,6-dichloropyrimidine of formula (I) comprises: a) cyclising a dialkyl aminomalonate of formula R1OC(=O)CH(NH2)C(=O)OR1 (II) with guanidine; b) chlorinating the resulting 2,5-diamino-4,6-dihydroxypyrimidine or formula (III) in the presence of an amide of formula HC(=O)R2 (IV); and c) reacting the 2-amino-4,6-dichloro-5-(substituted methyleneamino)-pyrimidine of formula (V) obtained with a carboxylic acid of formula R6COOH (VI) in an aqueous alcohol. R1 = 1-6C alkyl; R2 = 5- or 6-membered N-heterocycloalkyl (optionally N-substituted) or NR3R4; R3, R4 = 1-6C alkyl or benzyl; R5 = NH2; R6 = 1-6C alkyl or 3-6C cycloalkyl.
Patent PT-835868-E (PT)
Inventor: PALKOWITZ ALAN DAVID
IPC: C07D295/13
Filed: 1997-10-09
Abstract: The present invention provides pharmaceutically active compounds formula I <CHEM> or a pharmaceutically acceptable salt or solvate thereof having activity as selective estrogen receptor modulators, pharmaceutical compositions containing the compounds, and methods of using formula I compounds for treating conditions resulting from estrogen deprivation or the inappropriately high presence of estrogen. Also provided are methods and chemical intermediates for the production of compounds of formula I above.
Patent PT-895981-E (PT)
Inventor: KAMIGAUCHI TOSHIYUKI
IPC: C12P7/22
Filed: 1997-04-11
Abstract: The present invention provides a compound of the formula (I): <CHEM> wherein R<1> is hydrogen or hydroxy and R<2> is hydroxy or methoxy, pharmaceutically acceptable salts or hydrates thereof, a process for producing the same, a pharmaceutical composition which comprises the same and a microorganism which belongs to Aspergillus candidus and produces the compound.
Patent PT-961725-E (PT)
Inventor: SOMMER ULRICH
IPC: B62D31/00
Filed: 1998-02-27
Abstract: The passenger car has a supporting structure, with at least two longitudinal members (1). The longitudinal members are joined together in the middle by means of a torsionally rigid cross-member (2) which is constructed as a large-volume tubular profile and accommodates at least parts of the transmission, while the longitudinal members (1) at the side bend upwards from a floor panel (5) and in order to increase the flexural rigidity of the longitudinal member (1) about the transverse axis, the vertical extension of longitudinal member (1) is sufficiently great that the top edge (1) is located at least at the height of the seating-surface of the driver's seat.
Patent PT-991946-E (PT)
Inventor: ESMON CHARLES T
IPC: C07K14/74
Filed: 1998-06-26
Abstract: Plasma EPCR has been isolated, characterized and shown to block cellular protein C activation and APC anticoagulant activity. Plasma EPCR appears to be about 43,000 daltons and circulates at approximately 100 ng/ml (98.4+/-27.8 ng/ml, n=22). Plasma EPCR bound activated protein C with an affinity similar to that of recombinant soluble EPCR (Kdapp approximately 30 nM), and inhibits both protein C activation on an endothelial cell line and APC anticoagulant activity in a one-stage factor Xa clotting assay. Soluble plasma EPCR appears to attenuate the membrane-bound EPCR augmentation of protein C activation and the anticoagulant function of activated protein C. Soluble EPCR has also been detected in urine. Levels of soluble EPCR can rise in inflammatory disease associated with vascular injury and appear to be correlated with inflammation and disease states associated with abnormal coagulation. Since EPCR expression is restricted to larger vessels and is usually negative in cappillaries, these observations provide a mechanism for analyzing injury/stimulation of large vessel endothelial cells.
Patent PT-990849-E (PT)
Inventor: PORCHER JEAN-MICHEL GEORGES MA
IPC: F24H9/20
Filed: 1999-09-30
Abstract: The water heater (1) has a cold water input pipe (2) connected to a cold water circuit (3) and a hot water output pipe (4) connected to a hot water circuit (5). The overheating controller (30) has an enclosure (31) divided by a deformable membrane (34) in a cold chamber (32) and in a hot chamber (33). The membrane (34) has a first face (37) and a second face (38) respectively turned towards the hot (33) and the cold (32) chambers. The cold chamber (32) is at a pressure of that in the cold water circuit (3) and the hot chamber (33) is at the pressure of the hot water circuit (5), so that the membrane (34) is displaced due to the pressure difference between the chambers (32,33). The controller (30) has means (45), for limiting the temperature rise of the water contained in the cold chamber (32), which is supported on the membrane (34). The temperature limiter (45) includes a passage (46) through the membrane (34) so that the cold water in the chamber (32) can flow towards the hot chamber (33). The passage (46) has two orifices ending in the faces (37,38) of the membrane (34) the transversal section of each orifice (47,48) is greater than the transversal section of the passage (46).
Patent PT-1076540-E (PT)
Inventor: FELDGIEBEL RAINER
IPC: A61F13/08
Filed: 1999-04-19
Abstract: A compression bandage for supporting the tissue in the area between foot and knee, for example for treating venous and/or lymphatic swellings, is characterized in that it is designed with a ready-made foot part.
Patent PT-1095053-E (PT)
Inventor: THOMPSON ANDREW HUGIN
IPC: C12Q1/6872
Filed: 1999-07-13
Abstract: Provided is a method for characterising an analyte, which method comprises: <SL> <LI>(a) providing a compound in which the analyte is attached by a cleavable linker to a reporter group relatable to the analyte, the compound having the following formula: <EMI ID=1.1 HE=11 WI=43 LX=904 LY=1026 TI=CF> wherein either R comprises the reporter group and R' comprises the analyte, or R comprises the analyte and R' comprises the reporter group, and wherein n is 1 or 2; <LI>(b) cleaving the reporter group from the analyte; and <LI>(c) identifying the reporter group, thereby characterising the analyte. </SL> Also claimed are compounds of formula: <EMI ID=1.2 HE=35 WI=72 LX=738 LY=1927 TI=CF>
Patent PT-1109633-E (PT)
Inventor: MILLI SPANOVIC
IPC: B09B3/00
Filed: 1999-08-25
Abstract: The process and plant for preparation and treating of communal and industrial wastes into usable products are a system of plants consisting of basic and auxiliary facilities and enabling pre-preparation and preparation of sanitary improvement of initial influences, harmful for the nature and the environment, whereby such materials are subjected to pre-preparation that includes homogenisation of their contents, physical-chemical properties and other characteristics, and to technological treatment of procession and changing, consisting of exothermic reaction, vacuum-gas incapsulation and solidification. Thus obtained product - solidificate - is a usable hydro-insulating and power producing material, as well as a material that can be used for building of technical protective barriers against toxic, poisonous, noxious and radioactive materials, and technical material for primary and secondary industry processes, used for adding to other technological processes as well as for increasing of hydrophobicity of other basic materials. Its adding to gravel, asphalt and aerated concrete improves hydro-, thermo- and acoustic-insulation properties of the basic material, and its adding to fuels results in significant decrease of emission of sulphur dioxide into the atmosphere. The solidificate is pumpable, of < 1.00 kg/dm<3> density, does not mix with water, and its high compressibility enables pressing it into blocks, plates and briquettes of 1/1 to 1/3 of the initial volume. It has high stability and steadiness in environmental conditions, to solidify into rock after a longer period of time.
Patent PT-1123120-E (PT)
Inventor: AKWETE ADJEI
IPC: A61K9/00
Filed: 1999-09-17
Abstract: This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a particulate drug, a propellant, and stabilizing agent selected from an amino acid, an amino acid derivative and a mixture of the foregoing.
Patent IE-42263-L (IE)
Title: Dental solder
IPC: A61K6/847
Filed: 1976-02-02
Abstract: The invention relates to dental solder particularly suitable for joining parts of structural frameworks made of non-precious metal alloys, the framework being used in the preparation of bridges, crowns and the like. The solder compositions consist essentially of about 69 to 75% nickel, about 14 to 19.9% chromium, about 4 to 5.5% silicon and about 2.5 to 6% boron. The compositions may be modified to include up to about 6% molybdenum to increase corrosion resistance. The solder has a fusion temperature in the range of from about 1800 DEG to about 1950 DEG F and a diametrial tensile strength of at least 35,000 p.s.i. and a solder joint tensile strength of at least 70,000 p.s.i.
[US4077560A]
Patent IE-790544-L (IE)
Title: Facsimile installation
IPC: H04N1/00
Filed: 1979-08-08
Abstract: A facsimile transmitter/receiver includes a document analyser (1), and a document printer (3). It may also include bulk memory (2) which can act either as a further source or as a further destination. The transmitter/receiver is interfaced with a plurality n telephone lines (4, 5, 6) by means of n line circuits (7, 8, 9) each of which includes a line connector circuit 10, a modem 11 and a small amount of memory (25) (say sufficient for one scan line of a document), and a plurality p of temporary memories (15, 16, 17, 18) each of which has storage for facsimile signals corresponding to a complete page of a document. p is greater than n. Each of the temporary memories can be connected via a link selector (21) to any of the facsimile signal sources or destinations or to any of the telephone lines via a time-shared codec (22) which performs translation between "raw" facsimile signals and a less redundant form of signal suitable for transmission. Independent reading and writing helps isolate source(s) and destination(s) from slower transmission and connection delays inherent to telephone lines. <IMAGE>
[GB2015304A]
Patent IE-780921-L (IE)
Title: 1-acyl-2-hydroxy-1,3-diamino-propanes.
IPC: C07C233/35
Filed: 1978-05-08
Abstract: N1-acyl-N2-phenyl-1,3-diaminopropan-2-ols are disclosed which possess ulcer-inhibiting activities. Further disclosed are pharmaceutical compositions which are effective in the treatment and prophylaxis of ulcers and which comprise as a pharmacologically active ulcus-inhibiting ingredient N1-acyl-N2-phenyl-1,3-diaminopropan-2-ols, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable diluent. Further disclosed are processes for the preparation of the N1-acyl-N2-phenyl-1,3-diaminopropan-2-ols.
[US4191770A]
Patent FI-822583-L (FI)
Inventor: PAETZOLD WALTER
IPC: G03C1/76
Filed: 1982-07-21
Abstract: The tamper-proof document consists of a photographic material as information carrier comprising front- and back gelatine layers, the outer of the gelatine layers of which contain particles of a homo- or copolymer of an acrylic and/or methacrylic acid ester. The information carrier is laminated on one or both sides to a transparent foil by means of a hardenable adhesive. The document is remarkably safe against falsification.
Patent FI-823038-L (FI)
Inventor: MAASS GYNTHER
IPC: C08K5/54
Filed: 1982-09-02
Abstract: In a plastic organosiloxane molding composition which in the absence of water is capable of being stored and in the presence of moisture is cross-linked to a rubber, the composition comprising a hydroxypolydiorganosiloxane, a nitrogen base and heavy metal compound as cross-linking catalyst, and a cross-linking agent, the improvement which comprises employing as the cross-linking agent a compound of the formula   <IMAGE>   or a partial hydrolysis product thereof, wherein R is an optionally substituted alkyl, alkenyl or aryl group, R1 is hydrogen or R, R2 is an acyl, carbalkoxy or carbaroxy group or R1, a is 1-3, and n is 0, 1 or 2 and a+n</=3.
Patent FI-851258-L (FI)
Inventor: AKKERMAN JAAP MICHIEL
IPC: C08F283/00
Filed: 1985-03-28
Abstract: The invention provides a liquid coating composition curable at ambient temperature based on an  alpha , beta -ethylenically unsaturated carbonyl compound and a particular compound with an activated CH group such as a malonic oligomer or polymer.
Patent IE-801313-L (IE)
Title: Handle action in poker machine
IPC: G07F17/34
Filed: 1980-06-24
Abstract: Device to simulate the action of a conventional mechanical poker machine in an electrically operated poker machine in which the game cycle is initiated by the operation of an electric switch comprising a handle similar to that of a conventional machine connected to a friction device within the cabinet consisting of a spring loaded friction clutch arranged so that as the handle is pulled its movement will be resisted as in a conventional machine, the frictional resistance being automatically removed after the handle has travelled through a predetermined arc. The elements of the friction clutch are provided with ramps such that as the handle is pulled the frictional resistance progressively increases until at the end of the predetermined arc the ramps on the friction elements of the clutch reach their peaks and fall off into the next ramp immediately reducing the frictional load and an electric switch is actuated to start the machine.
[US4426082A]
Patent IE-33615-L (IE)
Title: Formwork for casting concrete slabs.
IPC: E04G11/38
Filed: 1969-11-04
Abstract: 1291829 Formwork for concrete slabs RAPID METAL DEVELOPMENTS Ltd 3 Nov 1969 [12 Nov 1968] 53465/68 Heading E1S Supporting formwork for the casting of concrete slabs comprises in combination a plurality of beams 10 as disclosed in Specification 1250875 which are supported on props 11, 12 and are interconnected by cross beams 15 adjustably supported on bars 14 forming part of the beams 10. Each cross beam consists of a flanged channel section of metal filled with a timber beam and provided at each end with notched positioning brackets for details of which Figs. 2 and 3, (not shown), should be referred to. (For Figure see next page)
[GB1291829A]
Patent IE-831570-L (IE)
Title: Process and reagent for the determination of direct and¹total bilirubin
IPC: G01N33/72
Filed: 1983-07-05
Abstract: 1. Process for the determination of direct and total bilirubin in body fluids in which the bilirubin is coupled with a diazonium salt and the extinction change thereby brought about is measured according to known methods, characterised in that the coupling is carried out in the presence of a buffer which adjusts the test solution to pH 3.5 to 8 and, as coupling component, there is used a diazonium salt of the general formula I   see diagramm : EP0098562,P8,F2   in which R1 signifies hydrogen, halogen, a lower alkyl, a lower alkoxy or a benzoylamino group, R2 hydrogen, a lower alkyl or lower alkoxy group, R3 hydrogen, halogen, a lower alkyl or a lower alkoxy group, whereby R1 and R3 do not simultaneously represent halogen, and X is an anion forming a storage-stable salt with the diazonium cation.
Patent IE-831632-L (IE)
Title: Compositions for the treatment of wounds.
IPC: A61K31/785
Filed: 1983-07-13
Abstract: An agent for the treatment of wounds comprising in the range of from 2 to 20% by weight of a graft copolymer of starch and hydrolysed polyacrylonitrile, of which in the range of from 5 to 90% of the carboxy groups are neutralised with aluminium, suspended in a physiologically tolerable lipophilic liquid or paste containing, e.g. one, two or three, surfactants, has a strong imbibing or wicking action and encourages rapid heating of a wound to which it is applied.
[EP0099074A2]
Patent IE-781635-L (IE)
Title: DERIVATIVES OF 2,6-BISAMINO-BENZO £1,2-d;5,4-d| BISTHIAZOLE
IPC: A61K31/495
Filed: 1978-08-11
Abstract: Compounds of the formula <IMAGE> wherein R1 and R1', which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 2 carbon atoms; R2 and R2', which may be identical to or different from each other, are each hydrogen or <IMAGE> but other than both hydrogen at the same time, where A is alkylene of 1 to 2 carbon atoms, R5 is hydrogen, lower alkyl, lower alkylamino-lower alkyl, lower alkoxy-lower alkyl, hydroxycarbonyl-lower alkyl, cycloalkyl of 5 to 8 carbon atoms, lower alkyl-cycloalkyl of 5 to 8 carbon atoms, phenyl or morpholino; R6 is hydrogen, lower alkyl, lower alkylamino-lower alkyl or lower alkoxy-lower alkyl; or R5 and R6, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring, where a 5- or 6-membered ring may comprise an additional sulfur or nitrogen heteroatom, and in the latter case said heterocyclic ring may optionally have one or two lower alkyl substituents, a lower alkoxy-carbonyl, a lower alkoxy-carbonyl-methyl, a hydroxy-lower alkyl, a trifluoroethyl, a cycloalkyl, a lower alkyl-cycloalkyl, a cyclohexylmethyl, a benzyl, a pyridyl, a piperidino, a phenyl, a fluoro-phenyl, a chloro-phenyl, a trifluoromethyl-phenyl, or an acetyl-phenyl substituent attached thereto; and R3 and R4, which may be identical to or different from each other, are each hydrogen, chlorine, bromine, lower alkyl, lower alkoxy, lower alkanoyl, hydroxycarbonyl, lower alkoxy-carbonyl, amino-carbonyl, phenyl, trifluoromethyl, nitro, cyano or amino; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antiarthritics and antirheumatics.
[US4344946A]
Patent IE-38258-L (IE)
Title: Fusidic acid conjugates.
IPC: C07J51/00
Filed: 1973-09-18
Abstract: 1447489 Fusidic acid conjugates LEO PHARMACEUTICAL PRODUCTS Ltd AS 19 Sept 1973 [6 Oct 1972] 46351/72 Heading C2U The invention comprises compounds of formulµ (wherein R is H or acetyl); their 24,25-dihydro and 17,20,24,25-tetrahydro derivatives; and salts of these compounds with pharmaceutically acceptable bases. They are prepared by reaction of a salt of glycine or taurine (e.g. an NEt 3 salt) with a reactive functional derivative of fusidic, 24,25- dihydrofusidic or 17,20,24,25-tetrahydrofusidie acid or 3-acetate thereof (e.g. an anhydride, mixed anhydride, acid halide or reaction product with a carbodiimide or N,N<SP>1</SP>-carbonyldiimidazole), optionally followed as appropriate by salification, catalytic double-bond hydrogenation or 3-acetylation. Oral compositions having micelle-forming properties similar to bile salts, comprise a compound I or II and a carrier.
[GB1447489A]