Patent EP-1361210-B1 (EP)
Inventor: MULLER GEORGE W
IPC: C07C255/32
Filed: 1997-08-11
Granted: 2008-12-24
Abstract: Cyano and carboxy derivatives of substituted styrenes of formula I <CHEM>  (a) X is -(CnH2n)- in which n has a value of 1, 2 or 3, and R<1> is alkyl of 1 to 10 carbon atoms, monocycloaIkyl of up to 10 carbon atoms, polycycloalkyl of up to 10 carbon atoms, or benzocyclic alkyl of up to 10 carbon atoms, or (b) X is -CH= and R<1> is alkylidene of up to 10 carbon atoms, monocycloalkylidene of up to 10 carbon atoms, or bicycloalkylidene of up to 10 carbon atoms;   R<2>   is hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 6 carbon atoms, alkylidenemethyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or halo; and R<3>   is (i) phenyl, unsubstituted or substituted with I or more substituents each selected independently from nitro, cyano, halo, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, or carbamoyl substituted with alkyl of 1 to 3 carbon atoms, acetoxy, carboxy, hydroxy, amino, amino substituted with an alkyl of 1 to 5 carbon atoms, alkyl of up to 10 carbon atoms, cycloalkyl of up to 10 carbon atoms, alkoxy of up to 10 carbon atoms, cycloalkoxy of up to 10 carbon atoms, alkylidenemethyl of up to 10 carbon atoms, cycloalkylidenemethyl of up to 10 carbon atoms, phenyl, or methylenedioxy; (ii) pyridine, substituted pyridine, pyrrolidine, imidizole, naphthalene, or thiophene; (iii) cycloalkyl of 4 -10 carbon atoms, unsubstituted or substituted with 1 or more substituents each selected independently from the group consisting of nitro, cyano, halo, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, substituted amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, phenyl;  each of R<4> and R<5> taken individually is hydrogen or R<4> and R<5> taken together are a carbon-carbon bond;  Y is -C IDENTICAL  N, or when R<4> and R<5> are hydrogen, Y is alternatively -COZ with the provisos that;  (iv) when Y is -COZ, Z is -NHR<6>R<6> and R<6> is hydrogen, then R<1> is not methyl; (v) when Y is -COZ, Z is -OH or -OR<7> and R<7> is benzyl, then R<1> is not methyl; and (vi) when Y is -COZ and Z is R<7> benzyl, then R<1> is not methyl and R<3> is hydroxy substituted phenyl.  Z is -OH, -NR<6>R<6>, R<7> or OR<7>;   R<6>   is hydrogen or alkyl of 1 to 6 carbon atoms; and R<7>   is alkyl or benzyl; are inhibitors of tumor necrosis factor  alpha , and nuclear factor kB and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.Cyano and carboxy derivatives of substituted styrenes of formula I <CHEM>  (a) X is -(CnH2n)- in which n has a value of 1, 2 or 3, and R<1> is alkyl of 1 to 10 carbon atoms, monocycloaIkyl of up to 10 carbon atoms, polycycloalkyl of up to 10 carbon atoms, or benzocyclic alkyl of up to 10 carbon atoms, or (b) X is -CH= and R<1> is alkylidene of up to 10 carbon atoms, monocycloalkylidene of up to 10 carbon atoms, or bicycloalkylidene of up to 10 carbon atoms;   R<2>   is hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 6 carbon atoms, alkylidenemethyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or halo; and R<3>   is (i) phenyl, unsubstituted or substituted with I or more substituents each selected independently from nitro, cyano, halo, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, or carbamoyl substituted with alkyl of 1 to 3 carbon atoms, acetoxy, carboxy, hydroxy, amino, amino substituted with an alkyl of 1 to 5 carbon atoms, alkyl of up to 10 carbon atoms, cycloalkyl of up to 10 carbon atoms, alkoxy of up to 10 carbon atoms, cycloalkoxy of up to 10 carbon atoms, alkylidenemethyl of up to 10 carbon atoms, cycloalkylidenemethyl of up to 10 carbon atoms, phenyl, or methylenedioxy; (ii) pyridine, substituted pyridine, pyrrolidine, imidizole, naphthalene, or thiophene; (iii) cycloalkyl