Patent SG-11201901557X-A (SG)
Title: Multispecific antibodies facilitating selective light chain pairing
Inventor: RAO ERCOLE
IPC: C07K16/24
Filed: 2017-08-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT omit VIII °nolo III 11110 lionoi Imo oimIE (10) International Publication Number WO 2018/037092 Al (51) International Patent Classification: C07K 16/00 (2006.01) C07K 16/24 (2006.01) (21) International Application Number: PCT/EP2017/071375 (22) International Filing Date: 24 August 2017 (24.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16306087.4 26 August 2016 (26.08.2016) EP (71) Applicant: SANOFI [FR/FR]; 54 me la Boetie, 75008 Paris (FR). (72) Inventors: RAO, Ercole; c/o Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). BELL, Christian; c/o Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). LANGE, Christian; c/o Sanofi-Aventis Deutsch- land GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). KROLL, Katja; c/o Sanofi-Aventis Deutsch- land GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). LEUSCHNER, Wulf-Dirk; c/o Sanofi-Aven- tis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). FOCKEN, Ingo; c/o Sanofi- Aventis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). LANGER, Thomas; c/o Sanofi- Aventis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). SPINDLER, Nadja; c/o Sanofi- Aventis Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt am Main (DE). (74) Agent: ZWICKER, Jork; ZSP Patentanwalte Partg mbB, Hansastr. 32, 80686 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) © (54) Title: MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING f .r1 (57) : Generally, the present invention relates to the field of antibodies. In particular, it relates to multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. The invention further relates to nucleic acids encoding for © these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions N comprising the antibodies. The invention also relates to methods of isolating the antibodies.