baber/WOPTO huggingface dataset:
Patent NZ-589240-A (NZ)
Title: Spirocyclic derivatives as histone deacetylase inhibitors
Inventor: VARASI MARIO
IPC: A61K31/438
Filed: 2009-04-14
Abstract: Disclosed is a compound of formula (I), wherein the substituents are as defined in the specification, and processes for its preparation. The compounds are inhibitors of histone deacetylases (HDACs) useful in the treatment of cancer.
Patent NZ-593248-A (NZ)
Title: Injection device with holding means to prevent unintentional movements of piston rod
Inventor: HAMBRECHT GERHARD
IPC: A61M5/315
Filed: 2009-12-01
Abstract: 593248 An injection device 10, comprising a housing being adapted to receive in its proximal housing portion 12 a container 16 with an injection fluid 18 and to receive in its distal housing portion 14 a dose setting and injection mechanism, where the mechanism includes a piston rod 28 that is axially displaceable with respect to the housing for dispensing injection fluid from the container, and a dose setting means comprising a threaded element 34, which threaded element 34 has an inner thread that is in engagement with the outer thread of the piston rod 28. The piston rod 28 has an outer thread and is arranged torque proof with respect to the housing. The dose setting means is designed so that its axial position relative to the housing is changeable, and is rotatable relative to the piston rod 28 and relative to the housing during setting of an injection dose. The threaded element 34 is held in torque proof manner relative to the piston rod 28 and to the housing during the injection of the beforehand set injection dose so that the threaded element 34 and the piston rod 28 are axially displaceable together with respect to the housing. The mechanism further comprises holding means in contact with the piston rod 28 and is designed such that the axial displacement of the piston rod 28 can be immobilized during use of the device except for the dispensing of the injection dose. The holding means are axially fixed with respect to the housing where the piston rod 28 has two longitudinal planar outer surfaces cut in the outer thread and arranged in parallel to each other on opposing sides of the piston rod 28. The holding means are in contact with both parallel outer planar surfaces of the piston rod 28 and exert a compressive force on the piston rod 28, and act as a clamp having two clamping portions each of which are in contact with a respective planar outer surface of the piston rod 28 to frictionally engage with the piston rod 28, and are made from a bent metal wire. The clamping portions have a curvature that is convex in direction to the piston rod 28, and the clamping portions of the holding means protrude with their respective convex wire portions in an opening of a guiding element 34 in which the piston rod 28 is axially guided and is held in torque proof manner due to an engagement of the outer planar surfaces of the piston rod 28 with corresponding planar surfaces of the opening of the guiding element.
Patent NZ-595029-A (NZ)
Title: Production of oil in microorganisms
Inventor: IM CHUNG-SOON
IPC: C12N1/00
Filed: 2008-06-02
Abstract: Disclosed is a microalgal cell comprising an exogenous gene encoding a sucrose invertase. Also disclosed is a method of producing a lipid comprising: culturing a recombinant microalgal cell comprising an exogenous sucrose invertase gene in a culture medium comprising a fixed carbon source until the recombinant microalgal cell accumulates at least 10% of its dry cell weight as lipid; and separating the lipid from the recombinant microalgal cell.
Patent NZ-596076-A (NZ)
Title: Beverage machine with retaining and actuation of hot water to capsule and opening of discharge controlled by common actuator, with capsule oriented vertically
Inventor: OZANNE MATTHIEU
IPC: A47J31/40
Filed: 2007-08-29
Abstract: 596076 A beverage machine has a device designed for brewing a beverage on the basis of ingredients contained in a capsule, the capsule having a cup-shaped housing closed by an overflow wall, the beverage brewing device having means for retaining the capsule in a defined position so that the overflow wall extends vertically, first opening means for opening a hot water inlet into the capsule while the capsule is retained in the defined position, second opening means for opening a beverage outlet from the capsule while the capsule is retained in the defined position, wherein the retaining means and the first and second opening means are controlled by a common actuator.
Patent NZ-597785-A (NZ)
Title: Compositions and method for preventing and treating fire blight
Inventor: ABELE ULF
IPC: A01N59/06
Filed: 2010-07-09
Abstract: 597785 Disclosed is a composition for treating and/or preventing fire blight, containing aluminum (III) ions in an aqueous solution at a concentration of from 15 to 60 mmol/L, wherein the pH of the composition is within the range of from 3.0 to 5.0, and additionally containing a humectant, wherein the humectant is selected from the list consisting of glycerin, propylene glycol, polyethylene glycol, sodium lactate, potassium lactate, calcium lactate, sorbitol, xylitol, glycerol, maltitol, invertase, polydextrose, magnesium chloride hexahydrate, ammonium chloride and their hydrates, calcium chloride and their hydrates, calcium nitrate and their hydrates or mixtures of two or more of these substances. Also disclosed are methods for treating fire blight comprising contacting a plant with the composition.
Patent NZ-597839-A (NZ)
Title: Process for the production of a cup and a plurality of cups
Inventor: MARSHALL NEIL
IPC: B65D1/26
Filed: 2010-07-06
Abstract: A process for the production of a container 1 having a bottom 8 and a sidewall 2 attached to the bottom 8, where the sidewall 2 comprises a rolled rim or other shape at its upper edge opposite to the bottom 8, and the container 1 comprises a single sidewall 2. The sidewall 2 is produced from a flat paper material or carton, which is subsequently formed into the sidewall 2. At least one shaping 5 is provided into the sidewall 2. The shaping 5 extends at least partially over the perimeter of the sidewall 2. The shaping 5 is inwardly and/or outwardly directed, and is compressed in its height.
Patent NZ-600707-A (NZ)
Title: 4-oxo-1h-quinoline-3-carboxamides as modulators of atp-binding cassette transporters
Inventor: VAN GOOR FREDRICK F
IPC: A61K31/47
Filed: 2010-12-10
Abstract: The present disclosure relates to 4-oxo-1H-quinoline-3-carboxamides as modulators of ATP-Binding Cassette (”ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present disclosure also relates to methods of treating ABC transporter mediated diseases using such modulators. 6,7-difluoro-N-(2-fluoro-5-hydroxy-4-tert-butyl-phenyl)-4-oxo-1H-quinoHne-3-carboxarnide; N-[4-(3,3-dimethylpyrrolidin-1-yl)-2-(trifluoromethyl)phenyl]-6-methyl-4-oxo-1H-quinoline-3-carboxamide; 8-cyano-N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinaline-3-carboxamide; and (2S,3S)-methyl 3-methyl-1-(4-(4-oxo-1,4-dihydroquinoline-3-carboxamide)-3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxylate. conditions which may be treated by the compounds of the disclosure include: cystic fibrosis, chronic bronchitis, recurrent bronchitis, acute bronchitis, male infertility caused by congenital bilateral absence of the vas deferens (CBAVD), female infertility caused by congenital absence of the uterus and vagina (CAUV), idiopathic chronic pancreatitis (ICP), idiopathic recurrent pancreatitis, idiopathic acute pancreatitis, chronic rhinosinusitis, primary sclerosing cholangitis, diabetes, dry eye, constipation, allergic bronchopulmonary aspergillosis (ABPA), bone diseases, and asthma
Patent NZ-604033-A (NZ)
Title: Glucagon analogues
Inventor: MEIER EDDI
IPC: A61P5/48
Filed: 2011-06-23
Abstract: Disclosed is a compound having the formula R1-X-Z-R2 wherein R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; R2 is OH or NH2; X is a peptide which has the formula I: His-X2-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-X16-X17-Arg-Ala-X20-Asp-Phe-Ile-Glu-Trp-Leu-X27-X28-X29 (I) wherein X2 is selected from Ser and Aib; X16 is selected from Glu and Y; X17 is selected from Arg and Y; X20 is selected from Lys and Y; X27 is selected from Leu and Y; X28 is selected from Ser and Y or absent; X29 is Ala or absent; wherein at least one of X16, X17, X20, X27 and X28 is Y; wherein each residue Y is independently selected from Lys, Cys and Orn; wherein the side chain of at least one amino acid residue Y of X is conjugated to a lipophilic substituent as described.
Patent NZ-605436-A (NZ)
Title: Crystalline forms of kinase inhibitors
Inventor: ZHANG GEOFF G Z
IPC: A61P35/00
Filed: 2011-06-08
Abstract: Disclosed herein are N-(4-{ 4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N’-(3-fluorophenyl)urea free base and crystalline forms thereof are suitable pharmaceutical ingredients for pharmaceutical compositions useful in the treatment of disease, for example, cancer. Additionally disclosed are processes for making said forms.
Patent NZ-605943-A (NZ)
Title: A lifting apparatus
Inventor: HAYTHORNE STEVEN
IPC: B62B3/06
Filed: 2011-10-21
Abstract: A lifting apparatus is disclosed. The lifting apparatus comprises a lifting mechanism, first and second drive wheels and one or more support wheels operatively coupled to the drive wheels. A sensor is provided to provide an output indicative of the load on the support wheel(s). A control system is configured to receive the output from the sensor and generate a signal for operating an actuation device to maintain the load on the support wheel(s) to substantially balance the lifting apparatus about the drive wheels.
Patent NZ-607854-A (NZ)
Title: High strength alpha/beta titanium alloy fasteners and fastener stock
Inventor: BRYAN DAVID J
IPC: C22F1/18
Filed: 2011-09-07
Abstract: An article of manufacture selected from a titanium alloy fastener and a titanium alloy fastener stock, the article of manufacture including a hot rolled, solution treated and aged alpha/beta titanium alloy comprising, in percent by weight 3.9 to 4.5 aluminium, 2.2 to 3.0 vanadium, 1.2 to 1.8 iron, 0.24 to 0.30 oxygen, up to 0.08 carbon, up to 0.05 nitrogen and up to a total of 0.30 of other elements. The up to a total of 0.3% of other elements includes one or more of less than 0.005 each of boron and yttrium, no greater than 0.10 each of tin, zirconium, molybdenum, chromium, nickel, silicon, copper, niobium, tantalum, manganese, and cobalt, and with the balance titanium and incidental impurities. The article of manufacture has an ultimate tensile strength of at least 170 ksi (1,172 MPa) and double shear strength of at least 103 ksi (701.2 MPa).
Patent NZ-624470-A (NZ)
Title: Cytotoxic peptides and antibody drug conjugates thereof
Inventor: DOROSKI MATTHEW DAVID
IPC: C07K7/02
Filed: 2012-11-07
Abstract: The disclosure relates to cytotoxic pentapeptides of general formula I. The disclosure also relates to antibody drug conjugates and their use in treating cancer. Example compounds include: 2-methylalanyl-N-[(3R,4S,5S)-l-{ (2S)-2-[(lR,2R)-3-({ (1S)-1-[(7S)-bicyclo[4.2.0]octa-1,3,5-trien-7-yl]-2-methoxy-2-oxoethyl} amino)-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl} -3-methoxy-S-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide 2-methylalanyl-N-[(3R,4S,5S)-1-{ (2S)-2-[(lR,2R)-3-({ (1S)-l-[(7R)-bicyclo[4.2.0]octa-1,3,5trien-7-yl]-2-methoxy-2-oxoethyl} amino)-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl} -3-methoxy-S-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide 2-methylalanyl-N-{ (3R,4S,5S)-1-[(2S)-2-{ (3R,4R,7S,12S)-7-benzyl-14-[3-chloro-4-(propan-2-yloxy)phenyl]-4-methyl-12-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)benzyl]-5,8,14-trioxo-2,9-dioxa-6,13-diazatetradecan-3-yl} pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl} -N-methyl-L-valinamide
Patent NZ-628481-A (NZ)
Title: Stabilising and analysing fatty acids in a biological sample stored on solid media
Inventor: GIBSON ROBERT
IPC: G01N33/92
Filed: 2013-01-11
Abstract: The invention relates to a method for stabilising fatty acids present in a sample such as bodily fluids (e.g. blood, saliva, breast milk, urine, semen, blood plasma and serum), using a solid medium (such as paper, a glass-based matrix, a paper-based matrix, a cellulose-based matrix, hydrophilic polymers, polytetrafluoroethylene, fibreglass and porous ceramics) comprising chelating agents (e.g. ethylenediamine-tetraacetic acid, ascorbic acid, citric acid, or salts thereof), antioxidants (e.g. butylated hydroxytoluene, butylated hydroxyanisole or t-butylhydroquinone) and less than than about 2 μg/cm2 of contaminants which is capable of stabilising fatty acids applied thereto, and a method for preparing such media. The invention further relates to a method for determining the fatty acid composition of a sample stored on such a medium.
Patent NZ-628728-A (NZ)
Title: Method of manufacturing flexible plastic film
Inventor: FRANK THOMAS GROSE
IPC: F16B5/08
Filed: 2014-08-13
Abstract: A method of manufacturing a flexible plastic film is disclosed. Plant for forming very wide plastic films is expensive and not widely available. If wide sheets are required they may be formed by joining smaller sheets rather than producing the wide sheet in one process step. The method comprises the steps of: i) Forming a length of first primary film (26) by a blown film extrusion process, wherein the first primary film comprises a first layer (26a) and a second layer (26b); ii) Forming a length of second primary film by a blown film extrusion process, wherein the second primary film comprises a first layer (26c) and a second layer (26d) ; and iii) Connecting an outer edge (24) of the second layer of the first primary film to an outer edge of the first layer of the second primary film by a substantially continuous heat sealing operation to form a secondary film having four layers, creating a join (25).
Patent NZ-702942-A (NZ)
Title: Method for producing a collagen membrane and uses thereof
Inventor: ZHENG MING-HAO
IPC: A61L27/24
Filed: 2013-06-12
Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen- containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen- containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.
Patent NZ-705077-A (NZ)
Title: Method and system for learning call analysis
Inventor: TAYLOR MATTHEW ALAN
IPC: H04M1/64
Filed: 2013-08-30
Abstract: A system and method are presented for learning call analysis. Audio fingerprinting may be employed to identify audio recordings that answer communications. In one embodiment, the system may generate a fingerprint of a candidate audio stream and compare it against known fingerprints within a database. The system may also search for a speech-like signal to determine if the end point contains a known audio recording. If a known audio recording is not encountered, a fingerprint may be computed for the contact and the communication routed to a human for handling. An indication may be made as to if the call is indeed an audio recording. The associated information may be saved and used for future identification purposes.
Patent NZ-712996-A (NZ)
Title: Container with pour spout
Inventor: BROZELL BRIAN
IPC: B65D23/10
Filed: 2014-04-09
Abstract: Known containers may not adequately control pouring of liquid from the container. A disclosed container (22, 122, 222, 322, 422, 522) includes a neck finish (34, 134, 234, 334, 434, 534) extending from a body (26, 126, 226, 326) and having at least two thickened wall portions (66, 266, 466, 566) circumferentially spaced apart and extending radially inwardly, and including interior surfaces (68, 468) disposed radially inwardly of a neck finish interior surface to at least partially establish an internal trough, and axially facing shoulders (48, 448, 548) axially recessed with respect to a sealing lip (54, 454) of the neck finish. The container provides a pour spout to direct flow of product through the pour spout and out of the container.
Patent NZ-713690-A (NZ)
Title: Dispenser cap arrangement
Inventor: DUIGNAN CATHAL
IPC: B65D39/00
Filed: 2012-10-31
Abstract: A dispenser cap arrangement for enclosing a portion of a dispenser of a medicament. In particular, the present invention relates to a dispenser cap arrangement, a dispenser cap a dispenser cap closure device, a method of closing a dispenser, and a closure arrangement. The dispenser cap arrangement comprises a dispenser cap comprising a hollow body having a lower open end for engaging with a body portion of a dispenser, and an upper open end for receiving a cap closure device for closing the upper open end, the upper open end comprising an engageable portion; and a cap closure device, comprising: an upper cap closure portion for engaging with the upper open end of the dispenser cap to close the upper open end of the dispenser cap; a lower cap closure portion for engaging with the engageable portion to secure the cap closure device to the dispenser cap; and a bistable portion (111, 112, 113) connecting the upper cap portion and the lower cap closure portion, the bistable portion being switchable between a first stable form in which the bistable portion is extended, and a second stable form in which the bistable portion is collapsed, wherein, when the bistable portion is in the second stable form, the upper cap closure portion engages with the upper open end of the dispenser cap to close the dispenser cap. The lower closure portion comprises a plurality of protrusions (103) extending radially outwards having an upper surface for engaging with the engageable portion of the hollow body. A lower surface of the lower lid closure portion is engageable with a surface of an article to be enclosed.
Patent NZ-717410-A (NZ)
Title: Heterocyclic containing entities, compositions and methods
Inventor: WILSON TROY EDWARD
IPC: C07D487/04
Filed: 2009-01-05
Abstract: Disclosed are tolylpyrido[2,3-d]pyrimidin derivatives of formula VIII-A wherein the substituents are as defined in the specification. Representative compound includes 2-(4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylpyrido[2,3-d]pyrimidin-4(3H)-one. Further disclosed is a composition comprising a pharmaceutically acceptable excipient and a compound as defined above, for use in treating of a disorder chosen from one or more of cancer, bone disorder, inflammatory disease, immune disease, nervous system disease, metabolic disease, respiratory disease, thrombosis, or cardiac disease, including inflammatory or an autoimmune disease, a respiratory disease, asthma, emphysema, allergy, dermatitis, rheumatoid arthritis, osteoarthritis, inflammatory bowel diseases, chronic obstructive pulmonary disorder, psoriasis, multiple sclerosis, disorders related to diabetic complications, lupus erythematosus, scleroderma, graft versus host disease, etc.
Patent NZ-720914-A (NZ)
Title: Linear gear shift mechanism
Inventor: HSIN-LIN CHENG
IPC: F16D15/00
Filed: 2016-06-07
Abstract: A linear gear shift mechanism includes a support rotator; transmission balls movably disposed at the support rotator and each provided with a cylindrical recess along radial direction thereof; driving posts with inward ends movably disposed in the cylindrical recesses along the radial direction of the support rotator; a gear shift unit movably connected to outward ends of the driving posts to drive the driving posts to rotate from the radial direction of the support rotator to but not reach the axial direction of the support rotator; an axial power input rotator having an inward-tilted power input annular surface; and an axial power output rotator having an inward-tilted power output annular surface, wherein the axial power input rotator and axial power output rotator flank and movably clamp the transmission balls between the inward-tilted power input annular surface, inward-tilted power output annular surface and outer circumferential surface of the support rotator.
Patent NZ-722492-A (NZ)
Title: Specific biomarker set for non-invasive diagnosis of liver cancer
Inventor: WONG BING LOU
IPC: G01N33/68
Filed: 2014-07-31
Abstract: Cells within liver tumour mass comprise a unique set of proteins/tumour antigens when compared to the normal liver tissues epithelial cells juxtaposed to the tumour. The presence of tumour antigens couples the production of auto-antibodies against these tumour antigens. The present invention relates to the identification and elucidation of a protein set that can act as a novel marker set for liver cancer diagnosis and prognosis. Specifically, it relates to a kit that enables diagnostic and prognostic measurement of auto-antibodies in serum of liver cancer patients. The present invention provides a non-invasive, specific, sensitive, and cost effective detection and quantification method by evaluating a set of validated liver cancer proteins/tumour antigens, which includes Bmi-1, VCC1, SUMO-4, RhoA, TXN, ET-1, UBE2C, HDGF2, FGF21, LECT2, SOD1, STMN4, Midkine, IL-17A or IL26, to complement the conventional diagnostic methods. In particular, the present invention relates to measuring auto-antibodies in serum of HCC patients against HDGF2.
Patent NZ-724638-A (NZ)
Title: A device management system
Inventor: TRIGGER BENJAMIN SHAUN DIXON
IPC: H04L12/24
Filed: 2015-04-08
Abstract: A system for managing usage of at least one network enabled device comprising a policy storage separately located relative to the user device, the policy database arranged to store information indicative of at least one usage policy set applicable to at least one respective user device, each usage policy set defining usage permissions and/or usage restrictions for a respective user device. Also arranged to store user device identification information for each user device, the information being indicative of and unique to a user device associated with the system and stored separately relative to the device. Also arranged to associate a usage policy set with a user device using the device identification information unique to the device. Also arranged to determine a usage request from a user device and to allow or deny the request based on the at least one usage policy set associated with the user device.
Patent NZ-728515-A (NZ)
Title: Organ care solution for ex-vivo machine perfusion of donor lungs
Inventor: HASSANEIN WALEED
IPC: A61M16/00
Filed: 2012-04-13
Abstract: Discloses a method of perfusing a donor lung at or near physiologic conditions comprising: flowing perfusion liquid through the lung, the perfusion liquid being at a physiologic temperature, the perfusion liquid comprising a nutrient, a colloid, a hormone, a steroid, a buffer, magnesium sulfate anhydrate, an antimicrobial agent and at least one selective phosphodiesterase inhibitor and at least one nitrate.