baber/WOPTO huggingface dataset:
Patent CA-3068377-A1 (CA)
Title: Compounds comprising stapled or stitched peptides for improved drug delivery
Inventor: FOSTER KEITH
IPC: A61P21/00
Filed: 2018-06-28
Abstract: The invention relates to improvements in drug delivery and to the use of Cell Penetrating Agents (CPA's) or Cell Penetrating Peptides (CPP's) which have been stabilized by, for example: i) stapling two amino acids to form Stapled CPP's (StaP's) or ii) stitching three or more amino acids to form stitched CPP's (StiP's). More particularly there is provided a drug carrying cell penetrating molecule (DCCPM) comprising: a biologically active compound (BAC), and a cell penetrating agent (CPA), which BAC and CPA are linked directly or via a bi-functional linker (BFL). The CPA is a stabilized peptide (CPP) which has a conformation imposed upon it by stapling to form a stapled peptide (StaP) or stitching to form a stitched peptide (StiP). The StiP or StaP comprise a cross link or bridge between at least two amino acids of the peptide and the cross link or bridge provides a cyclisation between at least two amino acids which are not formed by an olefin metathesis. Cyclisation may be achieved by one or more of: condensation of an aldehyde or ketone with a hydrazine or protected hydrazine; a thiol-ene Michael addition; a di-sulfide formation; a Huisgen 1, 3 di-polar cycloaddition; a reaction between an amine and carboxylic acid; a singlet or triplet based carbine reaction; or a Suzuki or Sonogashira coupling.
Patent CA-3070474-A1 (CA)
Inventor: LI CHUCK
IPC: C12N5/0735
Filed: 2018-08-07
Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.
Patent CA-3074811-A1 (CA)
Title: Temperature regulation system for vehicle hydraulic system
Inventor: CLIFTON CODY D
IPC: F15B21/0427
Filed: 2020-03-06
Abstract: A vehicle includes a chassis, a controllable vehicle component, a hydraulic circuit, a heater, a temperature sensor, and a controller. The hydraulic circuit includes a reservoir configured to store hydraulic fluid, a pump positioned to drive the hydraulic fluid from the reservoir and throughout the hydraulic circuit, and an actuator positioned to selectively receive the hydraulic fluid from the pump to selectively operate the controllable vehicle component.  The heater is positioned to facilitate selectively heating the hydraulic fluid. The temperature sensor is positioned to acquire temperature data indicative of a temperature of the hydraulic fluid. The controller is configured to monitor the temperature of the hydraulic fluid and selectively activate at least one of the heater or the pump to thermally regulate the hydraulic fluid (i) to maintain the hydraulic fluid within a target temperature range and (ii) independent of (a) an operator input and (b) engagement of the actuator.
Patent CA-3076298-A1 (CA)
Inventor: COUSINEAU CHRISTIAN
IPC: G02B6/44
Filed: 2020-03-19
Abstract: The present disclosure describes an optical fiber splice closure for joining two fiber optic cables. The optical fiber splice closure comprises a strain relief assembly that securely holds the two fiber optic cables being connected, and an enclosure that houses the strain relief assembly. The configuration of the strain relief assembly allows for securing the two fiber optic cables in a compact space, thus permitting a compact enclosure of the optical fiber splice closure, while also providing quick and easy installation in the field. A method of installing fiber optic cables using the optical fiber splice closure is also disclosed. The optical fiber splice closure and ease of installation also facilitates repairing damaged fiber optic cable. A method of repairing existing fiber optic cable is disclosed.
Patent CA-3077395-A1 (CA)
Inventor: FAN PINGCHEN
IPC: A61K31/5377
Filed: 2018-10-29
Abstract: Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Patent CA-3078014-A1 (CA)
Title: System and method for placement of railroad tie plate
Inventor: HARMAN JEFFREY KYLE
IPC: E01B9/02
Filed: 2020-04-15
Abstract: A railroad tie plate placement system facilitates or enables a railroad crew to minimize interaction with railroad tie plates while placing railroad tie plates in a proper orientation on a railroad or railway track in preparation for insertion under a rail. Thus, the described railroad tie plate placement system reduces labor costs and decreases risk of injury while providing for consistent placement of tie plates.
Patent CA-3079805-A1 (CA)
Inventor: MATSUURA RYO
IPC: A61K6/889
Filed: 2018-10-22
Abstract: The present invention provides a dental composition exhibiting high adhesiveness to both a tooth and a dental restorative material such as porcelain. The present invention pertains to a one-liquid type dental composition containing: a compound (A) represented by general formula (1), Y-SiRnX(3-n) (in the formula, Y represents a monovalent organic group having a polymerizable group, R represents a group selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group, X represents a hydroxyl group or a hydrolyzable group, and n represents an integer of 1 or 2. The plurality of R's may identical or different, and the plurality of X's may identical or different); a monomer (B) having an acidic group; and 1.0-50 mass% of water (C).
Patent CA-3082431-A1 (CA)
Inventor: SCHREIBER WALTER
IPC: E06B3/677
Filed: 2018-11-29
Abstract: The invention relates to an insulating glazing, which has a pressure equalization body, which comprises a capillary and a membrane, wherein: a first pane (12) is mounted on a first pane contact surface (2.1) of the spacer (1) and a second pane (13) is mounted on a second pane contact surface (2.2) of the spacer (1); the first pane (12), the second pane (13) and the glazing interior surface (3) of the spacer (1) enclose an inner pane intermediate space (15); the first pane (12), the second pane (13) and the outer surface (4) of the spacer (1) enclose an outer pane intermediate space (16); the pressure equalization body (8) is inserted into an opening (17) at the outer surface (4) of the spacer (1); the pressure equalization body (8) contains at least one gas-permeable membrane (9) and at least one capillary (10); the inner pane intermediate space (15) is gas-permeably connected to the atmosphere via the capillary (10) and the membrane (9); and the capillary (10) has a diameter of less than or equal to 1.2 mm in at least one section (19).
Patent CA-3082479-A1 (CA)
Inventor: BARBEE KRISTOPHER
IPC: B01F29/60
Filed: 2018-11-16
Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.
Patent CA-3088202-A1 (CA)
Title: Emergency station and method of use
Inventor: FLASTER MICHAEL LEONARD
IPC: F04B17/03
Filed: 2019-01-29
Abstract: An integrated, portable, battery-powered, variable-pressure electric liquid pump and power emergency station comprising a chassis; one or more wheels supporting the chassis; an electrically powered, variable-pressure liquid pump carried by the chassis; one or more rechargeable batteries powering the variable-pressure liquid pump to transfer liquid at variable pressures from a liquid source to a liquid destination; and one or more AC outlets carried by the chassis and powered by the one or more rechargeable batteries to provide emergency back-up power during power outage.
Patent CA-3089606-A1 (CA)
Inventor: LINDSEY QUENTIN
IPC: G06K9/34
Filed: 2019-01-25
Abstract: A method and system including: defining a geographic area (220, 502); receiving a plurality of images (202, 204, 206, 208, 210, 212, 214, 216); determining a plurality of image points (510); partitioning the geographic area into a plurality of image regions (512) based on the plurality of image points; and stitching the plurality of images into a combined image (520) based on the plurality of image regions.
Patent CA-3090963-A1 (CA)
Inventor: RAMAEKERS NICKY JOSEPH GERARDUS
IPC: E01F15/10
Filed: 2020-08-24
Abstract: The present invention relates to a roadblock for temporary installation to block traffic and/or as a security precaution, comprising: an elongated casing with two opposing longitudinal side walls and an, the two side walls joining, upper wall; and at least one casing support structure located in the elongate casing and connecting to both the side walls; supports for resting on the ground/surface connected to the lower side of the elongate casing and/or the lower side of the casing support structure, and plural stabilisation arms protruding from one of the longitudinal side walls.
Patent CA-3091943-A1 (CA)
Title: Variants of porcine trypsin
Inventor: STILLGER THOMAS
IPC: C07K14/62
Filed: 2019-02-22
Abstract: The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.
Patent CA-3092426-A1 (CA)
Title: Continuous synthesus of n-alkyl-nitratoethylnitramines at elevated pressures
Inventor: NIEDER ANIAN
IPC: C07C241/00
Filed: 2019-03-14
Abstract: The present invention relates to a continuous process for the preparation of N-alkyl- nitratoethylnitramines (e.g. NENA compounds, DINA).
Patent CA-3094725-A1 (CA)
Inventor: EHLIS THOMAS
IPC: C08K5/3475
Filed: 2019-04-01
Abstract: Use of an ultraviolet radiation absorbing composition as a light stabilizer for a shaped artificial polymer article, wherein the polymer is a synthetic polymer and/or a natural elastomer and wherein the ultraviolet radiation absorbing composition comprises the compound of the general formula (I) wherein n and m, independently from each other, are a number from 0 to 20, and at least one of m and n is = 1; and X1, X2, X3, X4 and X5 are the same or different and are independently selected from H, C(O)R1 with R1 being C8-C24-alkyl, or a group of the general formula (II) with R2 being H or halogen.
Patent CA-3096438-A1 (CA)
Inventor: FEITH RAYMOND
IPC: A61M5/165
Filed: 2019-04-04
Abstract: A check valve includes an upper housing having an inlet of the check valve, a lower housing axially coupled to the upper housing and having an outlet of the check valve, a valve portion cooperatively formed by the upper and lower housings, a passageway extending between the inlet and outlet, a first filter included in the upper housing to limit passage of undesirable matter in fluid flowing through the check valve, a second filter included in the lower housing to limit passage of undesirable matter in fluid flowing through the check valve, each of the first filter and the second filter including a plurality of vertical structures disposed in the valve portion and extending axially and radially in the valve portion, and a valve member positioned in the valve portion to selectively permit fluid to flow through the check valve.
Patent CA-3097820-A1 (CA)
Inventor: VRANCKEN PEETERS MARK-PAUL FRANCISCUS MARIA
IPC: A61B17/062
Filed: 2019-04-25
Abstract: The invention relates to a needle-suture combination comprising: a needle having a first needle end and a second needle end opposite to the first needle end, and a suture connected to the needle between the first needle end and the second needle end, wherein each of the first needle end and the second needle end comprises a needle point and a locking groove to receive a locking element of a needle holder, haractererized in that the first needle end and the second needle end each comprise a needle end stop surface between the groove and the needle point, wherein the needle end stop surface is arranged to cooperate with a needle channel stop surface of a needle channel of a needle holder.
Patent CA-3101227-A1 (CA)
Inventor: GAO PENG
IPC: A61K31/4196
Filed: 2019-05-28
Abstract: An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.
Patent CA-3102397-A1 (CA)
Title: Portable multi-purpose contact lens unit
Inventor: DEWAR ERIC
IPC: F21V33/00
Filed: 2020-12-11
Abstract: A portable multi-purpose contact lens unit ideal for removing or applying contact lenses while travelling in a convenient and hygienic manner. The unit consists of a reservoir to hold contact lens cleaning solution, a detachable contact lens case, a detachable top compai anent for sanitizing utensils and used liquid disposal, and a mirror on the bottom of the unit, making contact lens removal or insertion easy. The reservoir comprises a built-in manual spring-loaded push-valve allowing the flow of clean solution into the detachable lens case.
Patent CA-3102969-A1 (CA)
Title: High viscosity index comb polymer viscosity modifiers and methods of modifying lubricant viscosity using same
Inventor: GALBRAITH EWAN
IPC: C10M119/12
Filed: 2020-12-16
Abstract: ABSTRACT  A comb copolymer viscosity modifier may be made by polymerization comprising at least, or consisting essentially of, the following monomers: (a) a hydrogenated polybutadiene-based (alk)acrylate ester macromonomer (which repeat units may comprise from 7.0 wt% to 18 wt% of the repeat units of the comb copolymer viscosity modifier); (b) a C3-C8 alkyl (alk)acrylate ester monomer (which repeat units may comprise from 40 wt% to 71 wt% or from 45 wt% to 64 wt% of the repeat units of the comb copolymer viscosity modifier); and (c) a C12-C24 alkyl (alk)acrylate ester monomer, wherein repeat units based on the C12-C24 alkyl (alk)acrylate ester monomer comprise at least 21.0 wt% (and optionally up to 35.0 wt%) of repeat units of the comb copolymer viscosity modifier.  Lubricant compositions comprising the comb copolymer viscosity modifier, as well as uses thereof and methods for modifying viscosity, are also contemplated herein. Date Recue/Date Received 2020-12-16
Patent CA-3105610-A1 (CA)
Title: Gadolinium bearing pcta-based contrast agents
Inventor: NAPOLITANO ROBERTA
IPC: C07D471/08
Filed: 2019-08-06
Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
Patent CA-3105992-A1 (CA)
Inventor: GONZALEZ VICTOR MANUEL
IPC: A63B60/62
Filed: 2019-06-11
Abstract: There is provided a golf club head cover with golf ball holders on the outside comprising of a golf club head cover, golf ball holders attached to the outside of the golf club head cover and fasteners that attach the golf ball holders to the golf club head cover. The golf ball holders may form an animal or character feature such as an eye.
Patent CA-3106007-A1 (CA)
Title: Dental wrap, dental kit comprising the same, method of using the same, and method for whitening teeth using the same
Inventor: BANG SEONG-EUN
IPC: A61C19/00
Filed: 2021-01-13
Abstract: ABSTRACT  A dental wrap is provided. The dental wrap includes an adhesive layer and a backing layer, which is characterized in that it does not contain an active ingredient. The present invention can improve the user's feeling of use by applying various flavors that were difficult to use in the tooth whitening agent. Date Recue/Date Received 2021-01-13
Patent CA-3106369-A1 (CA)
Inventor: SHARMA SEAN
IPC: H04N21/234
Filed: 2019-11-12
Abstract: The disclosed computer-implemented method includes determining that audio quality is to be adjusted for a multimedia streaming connection over which audio data and video data are being streamed to a content player. The audio data is streamed at a specified audio quality level and the video data is streamed at a specified video quality level. The method also includes determining that a specified minimum video quality level is to be maintained while adjusting the audio quality level. Still further, the method includes dynamically adjusting the audio quality level of the multimedia streaming connection while maintaining the video quality level of the multimedia streaming connection at at least the specified minimum video quality level. Various other methods, systems, and computer-readable media are also disclosed.
Patent CA-3108572-A1 (CA)
Title: Crisp proteinaceous food product
Inventor: STESSEN ANGELA
IPC: A23J3/14
Filed: 2021-02-10
Abstract: A crisp proteinaceous food product provided from ingredients in which egg white proteins constitute the majority of total proteins present is described. Other ingredients include water, expanded starch(es), vegetable flour(s), and at least one source of vegetable protein. The protein can be labeled as being more than 50% (w/w) protein, and at least 50%  (w/w) of those denatured proteins can be ovalbumin (or trace their origin to ovalbumin).
Patent CA-3112134-A1 (CA)
Inventor: FERRAZ DE SOUZA WLADMIR
IPC: B01J35/10
Filed: 2019-08-02
Abstract: The present invention describes a mixture comprising carbonaceous raw material of low value as a fuel and a nanocatalyst. The catalytic mixture comprises from 1% to 50% by weight of a nanocatalyst; and from 99% to 50% by weight of carbonaceous raw material selected from petroleum coke, coal, petroleum residual heavy fraction, or a mixture thereof. The nanocatalyst comprises a carbon nanomaterial in a concentration of between 99.99% and 80% by weight and at least one alkali metal in a concentration of between 0.01% and 20% by weight, based on the total weight of the nanocatalyst, and the specific surface area of the nanocatalyst varies between 400 and 1300 m2/g. Furthermore, the present invention also describes a process of gasification of the catalytic mixture which comprises the steps of placing the mixture in a gasifier; heating the mixture in the presence of an oxidizing agent selected from air, pure oxygen, carbon dioxide, water vapour, or a mixture thereof at a temperature that varies between 200 and 1300ºC; and obtaining a gaseous product comprising H2, CO, CO2, CH4.
Patent CA-3112266-A1 (CA)
Inventor: CHOINIERE ERIC
IPC: H04B17/309
Filed: 2019-09-10
Abstract: Systems, methods and techniques are presented for discovering optimal solutions to satisfy communication traffic demands to a NGSO and GSO satellite constellations used for telecommunication. When multiple ground demands (mobile and stationary) are present, a satellite constellation requires an assignment of satellite resources to optimally match the ground demands. The systems, methods and techniques presented can utilize an optimization structure to maximize the objective function, using linear programming in combination with simulation and predictive features. The techniques presented determine optimal or quasi-optimal allocation of scarce and highly constrained satellite resources in an efficient manner. These techniques take into account maximizing capacity while protecting other geostationary and non-geostationary networks.
Patent CA-3113943-A1 (CA)
Inventor: MOORE STEPHEN TREY
IPC: G16H15/00
Filed: 2013-04-16
Abstract: Implementations provide methods including actions of processing patient data to generate one or more graphical representations of the patient data, at least one graphical representation of the one or more graphical representations including a waveform, displaying at least one waveform segment of the waveform, and displaying calipers associated with the at least one waveform segment, each caliper being associated with an interval, where displaying the calipers includes, for each caliper: receiving a measurement value of the interval associated with the caliper, determining respective positions of a first handle and a second handle of the caliper based on the measurement, and displaying the first handle and the second handle in the respective positions relative to the at least one waveform segment.
Patent CA-3114270-A1 (CA)
Title: Method for detecting silica
Inventor: PUUPPONEN SALLA
IPC: G01N21/64
Filed: 2019-09-27
Abstract: The present invention relates to utilization of lanthanide time resolved fluorescence for determining silica concentration. In the method sample comprising silica is admixed with a reagent comprising a lanthanide (lll) ion and optionally a chelating agent, silica in the sample is allowed to interact with the reagent comprising the lanthanide (lll) ion, followed by exciting the sample and detecting a signal deriving from the lanthanide (lll) ion, and determining the concentration of the silica in the sample by using the detected signal.
Patent CA-3114328-A1 (CA)
Inventor: UCHIDA Tomotake
IPC: B60C11/00
Filed: 2018-09-28
Abstract: Present invention provides a tire comprising a tread, at least one carcass ply placed radially inward of the tread and at least one ply placed radially inbetween the tread and the at least one carcass ply, the tread having a contact face of a contact width CW, the tread being axially divided into 3 regions, 2 shoulder regions located axially outward of the tread being composed of a shoulder rubber composition and a center region axially sandwiched by the 2 shoulder regions being composed of a center rubber composition different than the shoulder rubber composition, the at least one ply comprises a plurality of reinforcing cords extending with an angle A in a range from 35 to 55 degrees relative to circumferential orientation, a glass transition temperature of the center rubber composition is at least equal to 10°C higher than a glass transition temperature of the shoulder rubber composition.
Patent CA-3114567-A1 (CA)
Title: Anti-cd40 binding molecules having engineered fc domains and therapeutic uses thereof
Inventor: WANG JIEYI
IPC: C07K19/00
Filed: 2019-09-27
Abstract: The disclosure provides CD40-binding molecules comprising engineered human IgG domains, for example, human IgG1, IgG2, and IgG4 variants having mutations in the hinge domain, which exhibit altered binding activity to one or more Fey receptors. Also described herein are methods for selectively activating or inhibiting immune responses in a subject using the CD40-binding molecules.