baber/WOPTO huggingface dataset:
Patent CR-20190147-A (CR)
Title: CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
Inventor: SEBHAT IYASSU K
IPC: C07D491/18
Filed: 2017-09-25
Abstract: The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected from (II), (III), (IV), and (V), and ring B, n, R1, R2, R2A, R3, and R3A are as defined herein. The compounds of the invention are useful as mGluR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild congnitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.La presente invención proporciona ciertos compuestos de cromano, isocromano y dihidroisobenzofurano sustituidos de fórmula (I): o una sal farmacéuticamente aceptable de los mismos, en la que el anillo A es un resto seleccionado de: y el anillo B, n, R1, R2, R2A, R3 y R3A son como se definen en la presente memoria. Los compuestos de la invención son útiles como 10 inhibidores de mGluR2, o moduladores alostéricos negativos de mGluR2 (NAM), y pueden ser útiles en procedimientos de tratamiento de un paciente para enfermedades o trastornos en los que está implicado el receptor mGluR2-NAM, tales como la enfermedad de Alzheimer, deterioro cognitivo, deterioro cognitivo leve, esquizofrenia y otros trastornos del estado de ánimo, trastornos del dolor y trastornos del sueño, mediante la administración al paciente de una cantidad 15 terapéuticamente eficaz de un compuesto de la invención, o una sal farmacéuticamente aceptable del mismo. La invención también se refiere a composiciones farmacéuticas que comprenden un compuesto de la invención, o una sal farmacéuticamente aceptable del mismo, (opcionalmente en combinación con uno o más ingredientes activos adicionales), y un vehículo farmacéuticamente aceptable, y al uso de los compuestos y composiciones farmacéuticas de la invención en el 20 tratamiento de tales enfermedades
Patent EC-SP982754-A (EC)
Title: Protocolo para mensajes de voz
Inventor: BRYAN DAVID C
IPC: H04L1/08
Filed: 1998-11-25
Abstract: El presente invento proporciona un protocolo para mensaje de voz y proporciona un método y aparato para transmitir y recibir un mensaje selectivo de llamada que incluye un indicador de señal indicativo de por lo menos un receptor y una señal de datos destinada al receptor. El método transmite en primera instancia el indicador de señal (722) y retrasos a intervalos de tiempo previamente determinados. Subsecuentemente, el método transmite (706) por lo menos una parte del primer indicador de señal y una señal de mensaje para el receptor en una primera vez. Por ende, el presente invento proporciona una diversidad de tiempo para el indicador de señal antes de que se realice la transmición del mensaje en si. El médico podra utilizar una señal de alerta (es decir, un solo bit) (100) indicativo de un receptor asi como una dirección (202, 204) correspondientes al receptor. El presente invento presta apoyo a varios tipos de mensajes de grupo que podrían utilizarse simultáneamente con la transmisión de mensajes individuales mediante la fijación y transmición de señales de alerta adicionales (412, 16), señales de dirección (414, 418, 420), y señales de mensaje (408) (que pudieran ser intercaladas y distribuidas al pseudo-azar dentro de una sección de información de voz que forma parte de un marco, por ejemplo). Podrán adoptarse pasos alternos para transmitir mensajes a grupos de receptores. Por ejemplo, para grupos receptores que no cuentan con una dirección común, podrá fijarse un método y transmitirse bits independientes de alerta (108) correspondientes a los receptores de grupo, que se fijen y transmitan a cada dirección (228, 238) para cada receptor incluido en el grupo, y luego transmitir la señal de mensaje destinado para cada recptor dentro del grupo.
Patent FI-20055397-A (FI)
Inventor: KEMPPAINEN MATTI
IPC: B65H18/26
Filed: 2005-07-08
Abstract: A method in a belt reeler in which a reeling nip (7) is formed by a reeling core (6) or a growing machine reel (4) and at least one endless supporting member (3) travelling at least via a first wire guiding roll (1), and a second wire guiding roll (2). In the method several parameters are adjusted simultaneously to adjust the reeling process, of which parameters at least the first parameter and the second parameter are one of the following: web tension (P1), wire tension (P2), distance of the machine reel from the wire turning roll (P3), depression of the wire/machine reel (P4), surface draw (P5, P5', P5"), peripheral force (P6).
Patent FI-20125573-A (FI)
Inventor: YLI-KOSKI ESKO
IPC: F16B21/18
Filed: 2012-05-28
Abstract: The invention relates to an attachment ring (1)for attaching an object (4) in a flow channel (2). The attachment ring (1) has a first surface (5) for contacting the object (4) and a second surface (6) for contacting a surface of a shoulder (7). An expansion member (9) expands the attachment ring (1) by pushing the ends (11, 12) away from each other when the expansion member (9) is moved into the opening (10). At least one of the second surface (6) of the attachment ring (1) and the surface (7) of the shoulder is inclined in order to wedge the attachment ring(1) between the surface (7) of the shoulder and the object (4) when the attachment ring (1) is expanded by the expansion member (9).
Patent FR-1605065-A (FR)
Title: 6,13-dihydroquinacridone prepn in alpha crystal form - - from dialkyl 2,5-dianilino-3,6-dihydro terephthalate
IPC: C09B48/00
Filed: 1966-08-18
Granted: 1973-01-12
Abstract: Title cpds. are prepd. by heating the dialkyl 2,5-dianilino-3,6-dihydroterephthalate in the presence of a low boiling aromatic hydrocarbon at 200 to 300 degrees C at 8kg/cm2 pref. in the absence of O2 and then removing the solvent to give the prod. which is an intermediate in the prepn. of the pigment quinacridone formed by oxidn.
Patent GB-1051381-A (GB)
IPC: B65D71/70
Abstract: 1,051,381. Boxes for bottles &c. KEYES FIBRE CO. Feb. 8, 1965 [March 13, 1964], No. 5455/65. Heading B8P. A box for articles such as bottles comprises side walls 12, 14 and end walls 16, 18 each having hinged top and bottom flaps 24, 26, 28, 30 for folding inwardly and extending less than one half the distance to the opposite side or end of the box, there being top and bottom wall panels 20, 22 moulded with article-receiving pockets and being secured to at least some of the flaps. The top panel 20 has recessed pockets 34 to overlie the top of bottles B, each pocket being formed to one of three depths: first those adjacent the end walls 16, 18 have flat upper surfaces 36 (Figs. 3, 4, 5, not shown), secondly those adjacent the side walls 12, 14 and between the end rows have raised portions 40 raised to a depth above the surfaces 36 equal to the thickness of the end wall flaps 28, and thirdly the centre pockets have higher portions 38 raised to a depth equivalent to the combined thickness of the end wall flaps 28 and the side wall flaps 24. Thus when the box is closed end wall flaps rest on pocket surfaces 36, side wall flaps 24 rest on portions 40 and the exposed centre pocket uppermost surfaces are in the same plane as the upper surfaces of the side walls flaps (Figs. 3, 4). The bottom wall panel 22 (Fig. 5) has pockets 42 separated by upstanding posts 44 and is shaped to accommodate the thickness of the end wall bottom flaps 30 and the side wall bottom flaps 26 (Figs. 3, 4) in a similar way to the top panel 20 such that the bottom surfaces of the centre pockets 42 lie in the same plane as the outer surface of the side wall bottom flaps 26. The end walls 16 may have handles 32 and ventilation openings (not shown) may also be included. The top panel 20 may have a perforated score line 50 which is torn on opening, the box having been closed by glue spots 41 or stitching. In another embodiment to facilitate stacking the top panel 20 is shaped to protrude above the flaps 24 and the bottom wall 22 is recessed inwardly from the flaps 26.
Patent GB-1052243-A (GB)
IPC: C23C8/52
Abstract: 1,052,243. Surface hardening titanium. JOSEPH LUCAS (INDUSTRIES) Ltd. Sept. 4, 1963 [Sept. 12, 1962], No.34801/62. Heading C7U. Titanium is surface hardened by heating it at 550‹ to 800‹ C. in a fused salt mixture containing potassium and/or sodium cyanide and cyanate whereby a layer of nitride and oxide is formed. For temperatures in the range 550‹ to 650‹ the salt mixture may contain 5-10% of cyanate and 10-30% cyanide by weight, while above 650‹ C. the cyanate content may range up to 30%. The balance may be alkaline earth metal chlorides, carbonates or oxides.
Patent GB-1225200-A (GB)
IPC: A41G7/00
Filed: 1968-07-30
Abstract: 1,225,200. Fancy dress. TRENDON Ltd. 23 June, 1969 [30 July, 1968], No. 36246/68. Heading A3V. [Also in Division A6] Fancy dress comprises a paper sack 1 which is adapted to be worn inverted over the wearer's head and comprises front and rear panels 2, 12 connected by gussets 8, the front panel being formed with an opening 7 for the wearer to see through and the gussets with openings 6 for arms, the panels being decorated to give the article the appearance of an animal, e.g. zebra as illustrated in Fig. 2, or a person or other characteristic or futuristic figure. The fancy dress is made from a blank, Fig. 7, the side edges of which are then joined to form a tube and then the top closed, there being folds at the corners of the top at 20, 21, 22 and cut-outs 16 to give the appearance of "ears". The paper is preferably non-toxic and flame-proof.
Patent GB-1229275-A (GB)
IPC: F16K17/19
Filed: 1968-11-05
Abstract: 1,229,275. Valves. A/S TEKNOVA. 5 Nov., 1968 [8 Nov., 1967], No. 52440/68. Heading F2V. A discharge valve for a water separator tank (1, Fig. 1, not shown) in a compressed air system comprises a diaphragm 8 which forms a closure member for outlet seat 12, and which divides the valve body into an annular chamber 10 communicating through bores 11 with the water in the tank, and a chamber 9 which communicates with the upper part of the tank through a nozzle 15 and filter 17. A further nozzle 18 is provided to connect chamber 9 with outlet 14. In operation the compressed air supplied through nozzle 15 holds diaphragm 8 on seat 12 until the water level rises sufficiently for a small quantity, e.g. one drop, to flow into and temporarily block nozzle 15 whereupon the pressure in chamber 9 exhausts through nozzle 18 and the water pressure in chamber 10, together with spring 23, raises the diaphragm to permit some of the water in the tank to flow through bores 11 to outlet 14. This continues for about one second until the air pressure clears nozzle 15 and the pressure in chamber 9 reseats the diaphragm until the water level again reaches the top of cap 7. Nozzle 18 is provided with a silencing disc 22 which is urged towards shoe 19 by a light spring 23 which is easily overcome to permit fluid to flow through nozzle 18.
Patent GB-1230019-A (GB)
IPC: H01J29/76
Filed: 1968-06-25
Abstract: 1,230,019. Electron beam deflecting systems. MATSUSHITA ELECTRIC INDUSTRIAL CO. Ltd. 25 June, 1968 [11 July, 1967], No. 30248/68. Heading H1D. In a cathode-ray tube provided with a magnetic deflecting coil 2 adapted to be energized at high frequency, and including an internal conductive coating acting as an electrostatic screen, the coating is provided with gaps to reduce currents induced by the deflecting coil, these gaps extending over a greater length than the length of the coil. In Fig. 1, the coating is continuous at the end portions 6 and 7 and is provided with a helical gap in the portion 5 adjacent the coil 2. In a modification, Fig. 2 (not shown), there are a plurality of gaps running parallel to the axis of the tube, and in a further modification, Fig. 3 (not shown), the gaps are of zig-zag form. The coating may be formed by evaporation through a mask. The tube may be of the type wherein the electron beam density is modulated in accordance with the speed of deflection or of the type used for high-speed recording.
Patent GB-1232429-A (GB)
IPC: C01B39/02
Filed: 1968-07-29
Abstract: 1,232,429. Sodium aluminium silicates. SWISS ALUMINIUM Ltd. 29 July, 1968 [9 Aug., 1967], No. 36089/68. Heading C1A. Sodium aluminium silicates are prepared by adding a sodium silicate solution having a SiO 2  content of 0À15-3À5 mols./l. and an Na 2 O: SiO 2  molar ratio of not more than 0À5:1, over a period of at least 10 minutes, to a vigorously agitated sodium aluminate solution with an Al 2 O 3  content of 0À05-2À5 mols./l., an Na 2 O: Al 2 O 3  molar ratio not exceeding 10:1, with resultant precipitation of the sodium aluminium silicate. By using specific values of the above variables, at a specific temperature, e.g. between 0‹ and 100‹ C., products with different physical and chemical properties may be obtained. The aluminate solution may be a liquor drawn from the production of alumina, and the solution from which sodium aluminium silicate has been precipitated returned for use in the production of alumina.
Patent GB-1232452-A (GB)
IPC: E04C2/38
Filed: 1968-01-23
Abstract: 1,232,452. Laminated wallboards. BPB INDUSTRIES Ltd. 10 April, 1968 [23 Jan., 1968], No. 17171/68. Divided out of 1,232,451. Heading B5N. [Also in Divisions E1-E2] In a double-walled partition structure incorporating a runner and stud assembly as set out in Specification 1,232,451, each wall is formed of panels comprising a pair of wallboards laminated together only over spaced portions of their opposed faces which overlap to define rabbeted edges for interengagement with adjacent panels. The panels may be made of plasterboard or cellulosic material and incorporate a spacer strip laminated therebetween. For dimensions, sound insulating properties and specific examples of panels, the Specification should be referred to.
Patent GB-1232859-A (GB)
IPC: B65H51/28
Filed: 1968-08-08
Abstract: 1,232,859. Unreeling wire. NEWEY GOODMAN Ltd. 5 Nov., 1969 [8 Aug., l968], No. 37947/68. Heading D1J. Wire 33 that is drawn off a reel 12 passes over a driven pulley 17, a movable pulley 26 and then back over the pulley 17 again before being drawn off through guide means 37, 39, 40. The pulley 26 is biassed away from the driven pulley 17. If no tension is applied to the wire leaving the guide means 40 the frictional engagement between the driven pulley 17 and the wire 33 is insufficient to cause the wire to be unreeled, but if a tension greater than a predetermined minimum tension is applied to the wire the pulleys 17, 26 are urged towards each other and the increased friction between the wire 33 and the driven pulley 17 causes the wire to be unreeled. There may be more than one loop of wire between the pulleys 17, 26. If the pulley 26 approaches too close to the pulley 17 an arm 44 moving with the pulley 26 actuates a limit switch 43 to switch off the motor 25 that drives the pulley 17. An adjustable disc brake prevents free rotation of the reel 12. (For Figure see next column)
Patent GB-1233589-A (GB)
IPC: C10M133/52
Filed: 1968-08-12
Abstract: 1,233,589. Formamido compounds. ROHM & HAAS CO. 12 Aug., 1968 [11 Aug., 1967], No. 38478/68. Heading C2C. [Also in Divisions C3 and C4-C5] Formamido compounds may be prepared by reacting amines with formic acid or ethyl formate. In examples (B) 3,6,9,12-tetraazaformyl-4,7,10-trimethyl eicosyl alcohol is prepared by reacting octylamine with 2 mols. of propylene imine, one mol. of ethylene oxide and then formic acid; (C) N-(2-hydroxyethyl)-N- ethylformamide is prepared by reacting 2- aminoethanol with ethyl chloride and then ethyl formate; (D) diethanol formamide is prepared by reacting diethanolamine with ethyl formate; (E) N-hydroxyethyl-N<SP>1</SP>-formylpiperazine is prepared by reacting 1-piperazinoethanol with ethyl formate; and (F) product E is further reacted with an average of 2À9 mols. of ethylene oxide.
Patent GB-1238279-A (GB)
IPC: F01K13/02
Filed: 1969-10-30
Abstract: 1,238,279. Automatic control. WESTINGHOUSE ELECTRIC CORP. Oct.30, 1969 [Nov.26, 1968], No.53211/69. Heading G3R. In a nuclear reactor-steam turbine power plant, the reactor power and the turbine inlet and by-pass valves are automatically controlled by electrical signals dependent on turbine inlet steam pressure, turbine load and turbine speed errors. In Fig. 1, heat produced in the fuel rods of a nuclear boiling- water reactor 16 is transferred to the coolant which flows along the rods. Steam is collected at the top of a pressure vessel and directed through a conduit 38 to inlet valves 24 of the high-pressure section 20 of a multi-stage axial flow turbine 14 having a low-pressure section 22 on a common shaft 18 driving a synchronous electrical generator 12 connected to a power network. Exhaust steam from low-pressure section 22 and steam by-passing the turbine through valves 32 is condensed at 30, demineralized at 34, re-heated at 26 by steam passing between the high and low-pressure sections, and finally returned by pumps 36 to the pressure vessel. Electrical control signals are derived in dependence on turbine inlet pressure at 72, turbine load pressure at 66 and turbine speed at 64, and compared with reference values, which may be digital, for the purpose of controlling (a) the settings of closed-loop positional follow-up electrohydraulic control systems 54, 58 adjusting inlet and by-pass valves 24, 32 respectively. (b) regulator 48 which adjusts the settings of closedloop flow control systems associated with recirculating pumps 38, 40 and, for larger power changes, as well as in accordance with a programme, operates a drive 50 to alter the position of rods 46. Arrangements are described in which the control signals are subject to variation, limiting and the addition of integral components. Inter-connections between the controlling and controlled variables are changed, automatically and without shock, according to conditions such as starting-up, running, synchronizing and the magnitude of error. In one modification, an additional control signal dependent on the ratio of turbine load pressure to inlet pressure is introduced.
Patent GB-1238344-A (GB)
IPC: G01P15/02
Filed: 1968-07-04
Abstract: 1,238,344. Support for electric transducer. PHILIPS ELECTRONIC & ASSOCIATED INDUSTRIES Ltd. July 4, 1968 [July 7, 1967], No. 31916/68. Heading G1N. [Also in Division F2] A holder for supporting a coil, capacitor or pneumatic valve forming part of an instrument, such as an accelerometer, gravimeter or seismograph, comprises two end pieces 1, 2 inter-connected by leaf springs 3, 4, 5 or a torsional rod, together with flexible wires or strips 6-11 which attach the end pieces to a support 14 and are each disposed at a prescribed angle 12 to the radius through the attachment point and such that the torque exerted on one end piece is in the opposite direction to the torque on the other end piece. The arrangement allows movement of assembly 1-5 along the common axis through the end pieces and restrains displacement in a direction transverse the axis to an extent determined by the stress in members 6-11. The manner of attaching members 6-11 ensures a minimum variation in stress in response to displacements brought about by mechanical or temperature effects so as to minimize the production of an undesirable component of movement along the axis where members 6-11 do not lie exactly in planes perpendicular to the axis.
Patent GB-1250615-A (GB)
IPC: C10G21/00
Filed: 1968-05-02
Abstract: 1,250,615. Extracting aromatics. R. L. IRVINE. 1 Aug., 1969 [2 May, 1968], No. 20945/68. Heading C5E. The aromatics fraction of a hydrocracking product is extracted with a solvent of boiling- point below that of the hydrocrackate by introducing the latter into an extractor as the upper feed, introducing a middle feed comprising benzene and heavier hydrocarbons and some toluene, derived by distillation from a light reformate, introducing as a bottom feed a reformate fraction which is constituted by toluene and heavier fractions and is free from cyclohexane, and passing the aromatics-rich extract to an aromatics-solvent splitter. The upper feed may boil up to 410‹ F. if diethylene glycol solvent is used, or up to 425‹ F. for a sulpholane; methyl pyrrolidone is an alternative solvent. The bottom feed preferably has an end-point not exceeding 318‹ F. The aromaticssolvent splitter may be a steam heated reboiler. Water extraction is used for solvent recovery in both the raffinate and extract products.
Patent GB-1258591-A (GB)
IPC: B60W10/10
Filed: 1969-05-12
Abstract: 1,258,591. Hydrostatic transmission. ROBERT BOSCH G.m.b.H. 12 May, 1969 [11 May, 1968; 5 June, 1968], No. 23958/69. Heading F2D.  In a vehicle hydrostatic transmission driven by an I.C. engine 22, adjustment of the pump 23 and the motor 24, and control of the engine fuel supply at 21, are effected by three separate cam surfaces (30), (31) and (32), Fig. 2 (not shown), on a cam 4 rotated by a manually operated lever (17) acting through a collar 15 and spring 16, and moved axially by the high pressure 27 in the hydrostatic transmission acting on one end of the cam against a spring 12. The cam surfaces are designed to give optimum efficiency of the transmission and engine. A feed pump, pressure limiting valve, and a bypass valve may be provided. The pump and motor are reversible and may be of the axial piston type having swashplates or pear-shaped housings, or of the radial piston or vane type with adjustable stroke rings. Followers 18, (19), (20) for the cam 4 are connected to their respective engine, motor and pump controls through power amplifiers, the followers being constructed as pilot control slides for hydraulic servos, or providing electrical pulses for electromagnet or hydraulic servo control. The engine regulator 21 may be a fuel injection pump for a diesel engine, or a throttle valve for a petrol engine. The cam surfaces may be axially spaced on a common shaft, Fig. 3 (not shown). Again, Fig. 5 (not shown), the engine fuel supply is controlled by an electronic speed governor (R 1 ) which receives an actual speed signal from an engine-driven tacho (52) and a desired speed signal from the cam. The cam control lever (17<SP>1</SP>) is positioned by a second speed governor (R 2 ) which receives an actual speed signal from an output-driven tacho (53) and a desired speed signal from a manual lever (54). Also, Fig. 7 (not shown), the pump and motor are non- reversible, and the second governor (R 2 ) and tacho (53) are omitted, lever (17) being directly manually positioned. In Fig. 6 (not shown) the speed of the engine is again controlled by the speed governor (R 1 ), but the lever (17<SP>1</SP>) is positioned by a torque governor (R<SP>1</SP> 2 ) which receives actual torque signals from the motor displacement position and from the high pressure in the transmission, and a desired torque signal from a manual lever (54).