Patent SG-11201908267X-A (SG)
Title: Anticancer compounds
Inventor: CAÑEDO HERNÁNDEZ LIBRADA MARÍA
IPC: A61K31/351
Filed: 2018-03-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT onion °nolo momioomi olomoilowo oimIE (10) International Publication Number WO 2018/167270 Al (51) International Patent Classification: C07D 407/12 (2006.01) A61P 35/00 (2006.01) A61K 31/351 (2006.01) (21) International Application Number: PCT/EP2018/056665 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17382140.6 17 March 2017 (17.03.2017) EP (71) Applicant: PHARMA MAR, S.A. [ES/ES]; Avenida de los Reyes, 1, E-28770 Colmenar Viejo-Madrid (ES). (72) Inventors: CASEDO HERNANDEZ, Librada Maria; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). DE LA CALLE VERDU, Fernando; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industri- al La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). RODRIGUEZ RAMOS, Maria Pilar; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mi- na-Norte, E-28770 Colmenar Viejo-Madrid (ES). SCH- LEISSNER SANCHEZ, Maria del Carmen; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). ZUNI- GA GIRON, Paz; PHARMA MAR, S.A., Avenida de los Reyes, 1 Poligono Industrial La Mina-Norte, E-28770 Col- menar Viejo-Madrid (ES). (74) Agent: BERNARDO NORIEGA, Francisco; ABG PATENTES, S.L., Avda. de Burgos, 16D , Edificio EURO- MOR, E-28036 Madrid (ES). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) (54) Title: ANTICANCER COMPOUNDS 1-1 O N OR 1 OR2 Me0 OR 4 H Me (3?) Me 0 OR 3 CZ CZ 0 Me0 C (57) : Anticancer compounds of general formula (I), wherein R1 to R4 take various meanings, for use in the treatment of cancer. A novel Labrenziasp. strain named PHM005 with Accession Deposit Number CECT-9225, a method of producing compounds of the invention and analogues thereof by using the PHM005 strain and the Lab gene cluster codifying the biosynthesis of pederin-like and onnamide-like compounds are also provided.