Patent GB-1115844-A (GB)
Title: Growth inhibition of microbiological organisms
Inventor: HERSCHLER ROBERT JOHN
IPC: A01N37/42
Filed: 1965-08-23
Abstract: A composition suitable for addition to water, and especially to circulating water systems, to inhibit the growth of slime, comprises a halogenated levulinic acid of the formula <FORM:1115844/C1/1> wherein R is a hydrogen, bromine or chlorine atom, and wherein at least one and up to four occurrences of R is chlorine or bromine, or a metal or amine salt or an alkyl or phenyl ester or an amide of said acid, in admixture with a carrier.  Except when the composition contains 4 parts per million to 25% by weight of the halogenated levulinic acid or derivative thereof, the use as sole carrier of water, or other chemical solvents usually employed in the preparation of halogenated levulinic acid or derivatives thereof, is excluded. The composition may contain another biocidal agent, either as the carrier or in addition thereto, preferably at least one phenol compound having the formula <FORM:1115844/C1/2> wherein R is a C1-C10 alkyl group or a phenyl group, X is a chlorine or bromine atom or a nitro group, a is 0 or 1, b is 0, 1 or 2, and c is a integer from 0 to 5 - (a + b) with no more than three nitro groups, or a sodium or potassium salt thereof, or hexachlorophene.ALSO:Halogenated crude levulinic acid is prepared by chlorinating or brominating the crude product obtained by hydrolysing cellulosic material in dilute acidic solution, optionally in the presence of an acid catalyst, and concentrating the hydrolysed product to give a product containing predominately levulinic acid and a minor amount of lactones and other lowvolatile, soluble compounds.ALSO:A composition suitable for addition to papermaking slurry, to p  inhibit the growth of slime, comprises a halogenated levulinic acid of the formula:- <FORM:1115844/D1-D2/1> wherein R is a hydrogen, bromine or chlorine atom, and wherein at least one and up to four occurrences of R is chlorine or bromine, or a metal or amine salt or an alkyl or phenyl ester or an amine of said acid, in admixture with a carrier.  Except when the composition contains 4 parts per million to 25% by weight of the halogenated levulinic acid or derivative thereof, the use as sole carrier of water, or other chemical solvents usually employed in the preparation of halogenated levulinic acid or derivatives thereof, is excluded.  The composition may contain another biocidal agent, either as the carrier or in addition thereto, preferably at least one phenol compound having the formula:-  <FORM:1115844/D1-D2/2> wherein R is a C1 - C10 alkyl group or a phenyl group, X is a chlorine or bromine atom or a nitro group, a is 0 or 1, b is 0, 1 or 2 and c is an integer from 0 to 5-(a+b) with no more than three nitro groups, or a sodium or potassium salt thereof, or hexachlorophene.ALSO:Anti-microbial compositions comprise a halogenated levuline acid of the formula:  <FORM:1115844/A5-A6/1> wherein R is a hydrogen, bromine or clorine atom, and wherein at least one and up to four occurences of R is chlorine or bromine, or a metal or amine salt or an alkyl or phenyl ester or an amide of said acid, in admixture with a carrier.  Except when the compositions contain 4 parts per million to 25% by weight of the halogenated levulinic acid or derivative thereof, the use as sole carrier of water, or other chemical solvents usually employed in the preparation of halogenated levulinic acid or derivatives thereof is excluded. The compositions may contain another biocidal agent, either as the carrier or in addition thereto, preferably at least one phenol compound having the formula:  <FORM:1115844/A5-A6/2> wherein R is a C1 - C10 alkyl group or a phenyl group, X is a chlorine or bromine atom or a nitro group, a is 0 or 1, b is 0, 1 or 2, and c is an integer from 0 to 5- (a + b) with no more than three nitro groups, or a sodium or potassium salt thereof, or hexachlorophene.  The compositions may be in the form of liquids, solids, vapours, fumigants, emulsions and dispersions.  The compositions may be used as a wood-preservative and as rot proofing agents for fabrics.