Patent SG-11201811829Q-A (SG)
Title: Ethynyl derivatives
Inventor: BIEMANS BARBARA
IPC: C07D487/10
Filed: 2017-07-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111 111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/015235 Al 25 January 2018 (25.01.2018) WI P0 I P C T (51) International Patent Classification: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, CO7D 487/10 (2006.01) A61P 25/16 (2006.01) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, A61K 31/527 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/EP2017/067495 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 12 July 2017 (12.07.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 16179837.6 18 July 2016 (18.07.2016) EP Declarations under Rule 4.17: (71) Applicant (for all designated States except US): F. HOFF- — of inventorship (Rule 4.17(iv)) MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). Published: — with international search report (Art. 21(3)) (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- — sey 07424 (US). = (72) Inventors: BIEMANS, Barbara; Grenzacherstrasse 124, = 4070 Basel (CH). JAESCHKE, Georg; Grenzacherstrasse _ 124, 4070 Basel (CH). RICCI, Antonio; Grenzacherstrasse 124, 4070 Basel (CH). RUEHER, Daniel; Grenzacher- strasse 124, 4070 Basel (CH). O'HARA, Fionn; Grenzach- erstrasse 124, 4070 Basel (CH). = (74) Agent: POPPE, Regina; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every _ kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, _ _ KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = (54) Title: ETHYNYL DERIVATIVES = _ 10 ir) 110 M ei ir) Il © --.... 1101 O Il O el ...---, (57) : The present invention relates to compounds of formulas IA and IB IA IB or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to / its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The com- pounds may be used in the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2. uo, -----. - IB C