baber/WOPTO huggingface dataset:
Patent IL-85914-A0 (IL)
Title: 1,2,4-trioxane derivatives
IPC: A61K31/357
Filed: 1988-03-29
Abstract: 1,2,4-trioxane derivatives of formula: <CHEM>  (wherein      each of the subscripts m and n is equal to 0 or 1; the symbol Z represents an epoxide oxygen atom at the 5,6 or 6,7 positions, or a pair of electrons forming a double bond at the 5,6 or 6,7 positions; each of the symbols Ar<1> and Ar<2>, being the same or different, represents an aromatic group which is optionally substituted; each of the symbols R<1> and R<2>, being the same or different, represents a linear or branched alkyl group, which is optionally substituted, or R<1> and R<2>, taken together with the carbon atom to which they are attached, form an alicyclic group which is optionally interrupted by one or more oxygen, sulphur or nitrogen atoms and which group is optionally substituted with one or more alkyl or aryl groups, or one or more functional groups; and each of X and Y, being the same or different, represents a hydrogen atom or a functional group which contains oxygen, nitrogen or sulphur) are of use in the treatment of tropical diseases including malaria and have other physiological activities.
Patent IL-91046-A0 (IL)
Title: Macrocyclic polyaza derivatives,processes for the preparation thereof and pharmaceutical and diagnostic compositions containing the same
IPC: A61K49/04
Filed: 1989-07-19
Abstract: Macrocyclic compounds of the general formula I <IMAGE>  in which  @is a single or double bond,  q is the numbers 0-5, A and B, which are identical or different, are each a straight-chain or branched alkylene group with 2 to 6 carbon atoms, D is a nitrogen, oxygen atom, the group =C=O, =NR<2> with R<2> being a hydrogen atom or a C1-C6-alkyl group, the group <IMAGE> with R<3> being a hydrogen or halogen atom, a phenyl, a C1-C6-alkyl group which is optionally substituted by one or more phenyl and/or hydroxyl group(s), being the radical OR<5> where R<5> is a C1-C6-alkyl radical which is optionally substituted by 1 to 3 hydroxyl groups, being the substituent <IMAGE> where l is the numbers 0 and 1 and R<6> and R<7> are, independently of one another, hydrogen atoms, the radical R<5>, phenyl or benzyl radicals which are optionally substituted by 1 to 3 hydroxyl groups, or R<6> and R<7> are, together with the nitrogen atom, a saturated or unsaturated, 5- or 6-membered ring which optionally contains another nitrogen, oxygen, sulphur atom or a carbonyl group and which is optionally substituted by 1 to 3 radicals R<5>, or one of the substituents R<6> or R<7> is the radical <IMAGE> or being the substituent G where G is a second macrocycle which is bonded via a direct bond, a bis(carbonylamino) group (-NH-CO-CO-NH-) or via a C1-C20-alkylene group which optionally carries at the ends carbonyl (> CO) or carbonylamino (-NH-CO-) groups or oxygen atoms and optionally contains one or more oxygen atom(s), Z-, acyl- or hydroxyacyl-substituted imino groups or one to two C-C double and/or C-C triple bonds, and has the general formula II <IMAGE> in which D<1> has the same meaning as D with the exception that D<1> does not contain the substituent G, or is the radical -CH-, =C- or -N- and F<1> has the same meaning as F with the exception that F<1> does not contain the substituent G, or is the radical -CH-, or =C-,  E is a nitrogen, sulphur, oxygen atom, the <IMAGE> or >NR<4> group with R<4> being a hydroxyl group, being R<2> or being an optionally hydroxylated or carboxylated C1-C6-alkyl group, F is (-CHR<8>-)n or (=CR<8>)n with n being the numbers 0 or 1 and R<8> being R<1> or G,  R<1> is a hydrogen or halogen atom or a C1-C6-alkyl group, Z is a hydrogen atom or the group -CH2COOY with Y being a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83, with the proviso that at least two of the substituents Z are the radical -CH2COOY and that the macrocyclic compound of the general formula I does not contain more than one radical G, and the salts thereof with inorganic and/or organic bases, amino acids or amino amides are valuable diagnostic and therapeutic agents.
Patent IL-92178-A0 (IL)
Title: Process for the preparation of an insulin precursor in streptomycetes
IPC: C07K14/36
Filed: 1989-11-01
Abstract: A gene for a truncated proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construct is inserted into an expression vector, and the latter is used to transform a Streptomycetes host cell, with the result that the corresponding fusion protein is expressed and secreted. The fusion protein can easily be cleaved to give insulin precursors.
Patent IL-98127-A0 (IL)
Title: Process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate from chloromaleate or chlorofumarate or mixtures thereof
IPC: C07D213/803
Filed: 1991-05-13
Abstract: There is provided a process for the preparation of dialkyl pyridinedicarboxylate compounds and derivatives thereof by reacting a dialkyl chloromaleate or chlorofumarate or a mixture thereof with an ammonium salt optionally in the presence of ammonia and an appropiately substituted  alpha , beta -unsaturated aldehyde or ketone.
Patent AU-PO322396-A0 (AU)
Title: A method of measuring cardiac output by pulmonary exchange of oxygen and an inert gas with the blood utilising a divided airway
IPC: A61B/
Filed: 1996-10-25
Abstract: A method and apparatus for measuring pulmonary blood flow in a subject by pulmonary exchange of oxygen and an inert gas with the blood using a divided respiratory system. One method of isolating two or more divisions of the respiratory system uses a multi-lumen cuffed endobronchial catheter. In one embodiment, a triple-lumen cuffed endobronchial catheter is provided. In another embodiment, gas mixtures are supplied to each lumen using a bag-in-a-box type ventilator for each breathing system for synchronizing the rate and pressure of mixed gas supplied to the lumens.
Patent FI-20070157-A0 (FI)
Inventor: FORSBERG DAN
Filed: 2007-02-23
Abstract: The present invention performs a Binding Update or a Location Update message authentication independently and terminal-specifically in a home SAE gateway. A key, which is derived in a home AAA server from an initially set long term key, is given to a visited network for encrypting the update messages in Proxy Mobile IP. In Client Mobile IP, the key is transmitted to a mobile node for update message encryption. When the update message is received in the home SAE gateway, the key can be derived independently in the home SAE gateway without any key requests between the gateway and the home AAA server. Thus, it is possible to authenticate the binding or location update messages by verifying the two signatures. The present invention can also be implemented on a lower hierarchy of the system. The invention can be implemented in 3GPP standard releases enhanced with LTE technology, for instance.
Patent FI-20075381-A0 (FI)
Inventor: SUNDHOLM GOERAN
Filed: 2007-05-28
Abstract: A method in the fire protection of a warehouse, particularly a high-rise warehouse, which warehouse comprises at least one shelving in which there are shelves (2) one on the other and vertical supports (3) which form storage positions (4) for loads (5), in connection with which shelving, there is at least one vertical space (8) which in a fire situation functions as a flue space. In a fire situation, extinguishing medium mist is sprayed by at least one spraying head (10) such that the mist spray penetrates said flue space (8). The invention also relates to a fire-extinguishing apparatus.
Patent IL-106332-A0 (IL)
Title: Preparation of edible neem oil
IPC: A61K36/58
Filed: 1993-07-14
Abstract: This invention relates to a new process for refining and deodorizing the oil from the seeds of the neem tree by refining a neem oil solution with an alkaline solution of hydrogen peroxide to provide an edible grade of vegetable oil.
Patent IL-106622-A0 (IL)
Title: Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61P43/00
Filed: 1993-08-09
Abstract: 2-Substituted quinolylmethoxyphenylacetic acid derivatives of the general formula (I) <IMAGE>  in which     A, B, D, E, G and L are identical or different and stand for hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or for straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, or for aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R<1> stands for halogen, cyano, nitro, azido, hydroxyl, carboxyl, trifluoromethyl, trifluoromethoxy or trifluoromethylthio, or for straight-chain or branched alkenyl or alkynyl in each case having up to 8 carbon atoms, each of which is optionally substituted by phenyl or cycloalkyl having 3 to 8 carbon atoms, or for cycloalkyl having 3 to 8 carbon atoms or phenyl, or for straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 6 carbon atoms, R<2> stands for hydrogen or for straight-chain or branched alkyl having up to 6 carbon atoms, or  for cycloalkyl having 3 to 12 carbon atoms, R<3> stands for hydroxyl, for straight-chain or branched alkoxy having up to 8 carbon atoms or phenyl, or  for a group of the formula -NR<4>SO2R<5> or -NR<6>R<7>,  in which R<4>, R<6> and R<7> are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, phenyl or benzyl, R<5> denotes trifluoromethyl or phenyl which is optionally substituted by halogen, cyano, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl which, for its part, can be substitued by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, hydroxyl or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms  and their salts. 2-Substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of appropriately substituted phenols with quinolylmethyl halides or by reaction of unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The 2-substituted quinolylmethoxyphenylacetic acid derivatives can be employed as active compounds in medicaments. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.
Patent IL-127687-A0 (IL)
Title: The preparation of 3-pyrroline-2-carboxylic acid derivatives
IPC: C07D401/12
Filed: 1997-07-14
Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II
Patent IL-130206-A0 (IL)
Title: Container having two or more compartments
IPC: A61J1/00
Filed: 1997-12-25
Abstract: A container for storing two components separately and then mixing them prior to use includes a housing having an opening and a neck portion, a displaceable member, and a closure member. The housing is formed with a first compartment and a second compartment intercommunicating at the neck portion. The displaceable member has a partition wall for sealing the neck portion. The displaceable member is formed such that the partition wall moves from a non-sealing position in which the first and second compartments intercommunicate to a sealing position in which the neck portion is sealed. The displaceable member also may feature at least one conduit for allowing introduction of a component through the opening into the housing. The closure member seals the at least one conduit of the displaceable member and/or the opening of the housing. The displaceable member may be moved by rotating, pushing or pulling and may be moveable by a portion exterior to the housing. The seal formed by the partition wall of the displaceable member may be reformable, i.e., capable of being resealed. A pre-packaged, single use, two compartment container according to some embodiments of the invention have an unremovable closure member, an unreformable seal, an unfastenable closure member after it has been removed or is constructed in a manner or of materials which allow only a single use. The two-compartment container may also include a dosing assembly for dispensing a predetermined quantity of mixed formulation.
Patent IL-138118-A0 (IL)
Title: Method and device for producing an embossed web material and product made in this way
IPC: B31F1/07
Filed: 1999-03-01
Abstract: For the production of a sheet product including at least two layers (V 1 , V 2 ) it is suggested, among other things, an embossing device including a first pressure roller ( 5; 105 ) interacting with a first and a second embossing cylinder ( 1, 3; 101, 103 ) provided with respective points ( 1 P, 3 P; 101 P, 103 P) on their cylindrical surface.
Patent IL-140821-A0 (IL)
Title: Intraurethral magnetic valve
IPC: F16K31/08
Filed: 1999-07-09
Abstract: An intraurethral magnetic valve for insertion in the human urethra of a person suffering from incontinence. The intraurethral magnetic valve includes a nonferromagnetic cylindrical housing, a valve seat assembly attached to one end of the housing, a spherical magnetic valve element disposed for universal movement in the housing, and a ring for retaining the valve element which is attached at the other end of the housing. The valve seat assembly has a nonferromagnetic valve seat sealing surface and ferromagnetic ring, each having concentric apertures for passage of fluid. The valve element is maintained in closed check position against the valve seat by attraction to the ferromagnetic ring, restricting the flow of fluid through the valve. An external magnet is used to impart magnetic torque and attraction to the valve element displacing it from the valve seat and opening the valve for fluid flow. On removal of the external magnet, the valve element returns to its closed check position on the valve seat. The intraurethral magnetic valve may further include a mechanism for relieving excessive fluid pressure at the end of the housing having the valve seat assembly, in which the valve seat assembly is axially slidable within the housing, rather than being attached to the housing. The mechanism has a spring disposed in the housing on the side of the valve seat assembly opposite the valve element, between another retaining ring and the valve seat assembly. The spring pushes the valve seat assembly against an annular flange attached to the housing. Under normal conditions, the valve seat assembly engages the annular flange. During excessive hydrostatic pressure, the pressure against the valve element and valve seat assembly compresses the spring to disengage the seat assembly from the annular flange and permit slow release of fluid through a passageway around the valve seat assembly until the excessive pressure is reduced.
Patent IL-144587-A0 (IL)
Title: Towing vehicle for persons moving on rollers or sliding bodies
Inventor: TIMM ANTONIO
IPC: B63B35/81
Filed: 2000-01-22
Abstract: The invention relates to a towing vehicle which moves on rollers or sliding bodies, for towing persons. The towing vehicle is provided with a motor drive which drives a driving wheel (1) that is mounted in a chassis (2). The towing vehicle can be controlled by the person through a steering column (8). According to the invention, the chassis (2) also has a supporting wheel (4) which is located behind the driving wheel (1). The steering column (8) is fixed to the chassis by a pitch joint (7) running parallel to the axis of rotation of the driving wheel (1), said pitch joint being situated in front of the axis of the driving wheel (1). The invention enables the towing vehicle to be used especially for towing inline skaters at high speeds.
Patent IL-146687-A0 (IL)
Title: Improved brush-seal designs for turbines and similar rotary apparatus
IPC: F16J15/32
Filed: 2001-04-05
Abstract: An axial flow turbine is provided with retractable packing and brush seals between stages. The retractable packing is provided with separate packing segments (201) which form a ring when closed during normal operation and expand to a larger clearance during start-up and shut-down. A brush seal segment (217,219) is provided on each packing segment (201), such that when segments are closed during normal operation, the brush seal likewise forms a ring. The ends of the packing segments are cut along radii extending from the central shaft, and the ends of the brush seal segments are canted so as not to be parallel with the ends of the packing segments in which they lie.
Patent IL-150615-A0 (IL)
Title: Method and apparatus for exchange of information in a communication network
IPC: H04L12/66
Filed: 2000-09-03
Abstract: A technique for connecting a dialed B-party number to a data object is described. The connecting of a B-party number to a specific data object, hereafter referred to as phonepage, will allow an A-party direct access to information that a B-party wishes to display to a calling party. The phonepage resides in a memory in a telecommunications network, or in a memory in a data-communications network connected thereto. The phonepage may have a similar appearance to an Internet web page, but may also take other appearances. The displaying of the phonepage may be made dependent upon the capabilities of the A-party user equipment.
Patent IL-158699-A0 (IL)
Title: Method for producing components for electronic devices
IPC: H05K3/46
Filed: 2002-05-15
Abstract: Method for the production of components for electronic apparatuses from a sheet-like substrate material, which has through-holes and indentations on at least one surface, an intermediate layer on at least one surface of the substrate material, and a metal foil adhering to said layer, comprising the steps (a) coating of a sheet-like substrate with a composition forming the intermediate layer, (b) application of the metal foil to the coating and (c) bonding of the parts by pressure and heating. The method is characterized by the use of a liquid, solvent-containing and heat-curable two-component system comprising at least one curing agent and at least one curable compound, which system is applied as the layer to at least one surface of a substrate material and then dried. A metal foil is then laminated with the resulting solid and dry layer under pressure and at elevated temperature and the layer is cured. Particularly preferably, circuit boards are produced by the method according to the invention.
Patent IL-165196-A0 (IL)
Title: Closure devise comprising tamper-proof security seal
IPC: B65D41/34
Filed: 2004-11-14
Abstract: The stopper incorporates a cylindrical body (1) attachable to the edge of the container or bottle, and a cover (2) with a hinge (3) for attachment to it, in the upper part of such a body (1) a mouthpiece (4) blockable by means of a neck of the cover (2), is incorporated, through which mouthpiece (4) the pouring and/or the direct consumption of the contents of the bottle in which said stopper is applied can be carried out. On the body of the stopper (1) near to its edge and in correspondence with a sector of its surround, it has a sealing strip (5) joined by breakable points (6), to the body (1). In said strip in-cuts (7) are established for the retaining of corresponding projections (9) in the cover (2), in its closed position, this sealing strip (5) being provided with end wings (8) that are positioned in depressions (10) of the side surface of the cover (2), without projecting from this, the positioning of a shield (14) of the cover (2) in a depression (15) of the upper edge of the sealing strip (5), assisting in the tamper-proofing, as well as a number of vertical ribbings (12) of the strip (5) and the mouthpiece (4) that are out-of-line with respect of the centre of the stopper, with a displacement towards the sealing strip (5) area. <IMAGE>
Patent IL-180920-A0 (IL)
Title: Device for clamping a tool insert in a grinding machine
IPC: B24D99/00
Filed: 2007-01-24
Abstract: The device has a support (9) with receiving sides to receive a plate (2). A simple movement of a piston (35) in a spindle of a headstock (1) drives a cam (32) such that a clamping lever (13) moves by introducing its jaw in the plate`s hole. The jaw draws the plate towards rear that is then pressed against the support`s vertical side. The plate is also pressed against the support`s horizontal side under the effect of a safety jaw (14).
Patent IL-181131-A0 (IL)
Title: USE OF C3a AND DERIVATIVES THEREOF AS A BIOMARKER FOR COLORECTAL ADEMONA AND/OR CARCINOMA; DIAGNOSIS METHOD AND TEST SYSTEM USING THE SAME
Filed: 2007-02-01
Abstract: The invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of transthyretin in said isolated sample material, and c)comparing the determined level of transthyretin with a reference value. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of transthyretin as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual.
Patent RO-127914-A0 (RO)
Title: Ventilation device with heat exchanger
Inventor: EPURAN ION-HORIA
IPC: D06C27/00
Filed: 2012-03-05
Abstract: The invention relates to a ventilation device with heat exchanger intended to ventilate rooms while a heat exchange takes place between the air current coming out from the room and the air entering the room from the exterior, with a view to saving the energy required for maintaining thermal comfort. According to the invention, the device comprises a housing () made of a thermally insulating material wherein there is placed a partition wall () for thermal transfer, two channels () being formed due to the shape of the wall () and the housing (), namely a fresh air intake channel and a used air outlet channel, respectively, and two fans () which generate the air currents for ventilation being mounted in order to provide the desired air flow rate.
Patent RO-134367-A0 (RO)
Title: 4-isopropyl-1,3-oxazol-5()-one derivatives containing in second position a diarylsulphonyl substitute with antimicrobial action
Inventor: APOSTOL THEODORA - VENERA
IPC: C07D471/06
Filed: 2019-10-23
Abstract: The invention relates to 4-isopropyl-1,3-oxazol-5(4H) -one derivative compounds to be used in antimicrobial therapy and to a process for preparing the same. According to the invention, the compounds have the general formula I, where X is H, Cl or Br. The process, as claimed, consists in cyclization of acyclic intermediates of the N-acyl- α-amino acid class under the action of ethyl chloroformate, in the presence of N-methylmorpholine.