Patent RU-2214602-C1 (RU)
Title: Method for predicting addition of inflammatory complications in acute period of cranial trauma and method for their prophylaxis
Inventor: SUMNAJA D B
IPC: G01N33/52
Filed: 2002-09-09
Granted: 2003-10-20
Abstract: FIELD: medicine, neurosurgery, neurology, immunology. SUBSTANCE: one should detect the value of humoral blood response taking into consideration the presence of functional asymmetry syndrome in immune response at dextro- and levohemispheral localization of lesion foci. Moreover, one should additionally detect the value of patient's humoral liquor response, also, taking into account the presence of functional asymmetry syndrome in immune response at dextro- and levohemispheral localization of lesion foci, moreover, as value of humoral response of blood and liquor one should apply cytokinic response of proinflammatory interleukin- 1beta and addition of inflammatory complication at dextro-and levohemispheral localization of lesion foci is predicted since 1st till 14th d after the onset of cranial trauma at the following values of this parameter in blood and liquor, at dextrohemispheral localization of lesion focus: in blood: above 350pg/ml, and, also, below 150 pg/ml during 1st-3d d, above 150 pg/ml during 4th-7th d and above 62 pg/ml during 8th-14th d; in liquor: above 80 pg/ml, and, also, below 30 pg/ml during 1st-3d d, above 71 pg/ml during 4th-7th d and at no normalization of its values to the end of 8th-14th d, and at levohemispheral localization of lesion focus: in blood: above 200 pg/ml, and, also, below 40 pg/ml during 1st-3d d, above 240 pg/ml during 4th-7th d and above 120 pg/ml during 8th-14th d; in liquor: above 17 pg/ml, and, also, below 5 pg/ml during 1st-3d d, above 48 pg/ml during 4th- 7th d and at no normalization of its values to the end of 8th- 14th d. For prophylaxis of addition of inflammatory complications in acute period of cranial trauma it is necessary to conduct immunocorrecting therapy according to the results of prediction for addition of inflammatory complications in acute period of cranial trauma, moreover, it is carried out since 4th-14th d after cranial trauma appeared at all the values of parameter tested at predicting addition of inflammatory complications in acute period of cranial trauma - proinflammatory interleukin-1beta - in blood and liquor, except values during 1st-3d d after the onset of cranial trauma for dextrohemispheral localization of lesion focus - in blood - above 350 pg/ml and in liquor - above 80 pg/ml, and for levohemispheral localization of lesion focus - in blood - above 200 pg/ml and in liquor - above 17 pg/ml, moreover, patient is injected with immunostimulating preparation -betaleukin (recombinant IL-1beta) daily for 7 d per 5 ng/kg yield of antiphlogistic cytokin as interleukin-1beta or contactly affected with immunomodeling low-intensity laser radiation at 0.89 mcm wave length onto carotid and vertebral arteries from both sides, onto projections of right and left adrenal glands, ethmoid bone and mastoid process from the side of lesion, at the following modes of impact: onto carotid arteries - daily for 10 d per 1-3 min/each one at radiation at 1500- 3000 Hz impulse frequency and impulse power of 5-10 W; onto vertebral arteries - daily, for 10 d per 5-3 min/each one at radiation at impulse frequency of 80-150 Hz and impulse power of 5-10 W; onto projections of right and left adrenal glands - daily, for 5-7 d per 1-2 min/each, at radiation at impulse frequency of 80-150 Hz and impulse power of 3-7 W; onto projection of ethmoid bone - daily, for 5-7 d per 5 min at impulse frequency of 1500- 3000 Hz and impulse power of 3-7 W, onto projection of mastoid process - daily, for 5-7 d per 3-5 min at impulse frequency of 1500-3000 Hz and impulse power of 3-7 W. EFFECT: higher accuracy of prediction. 2 cl, 10 ex, 2 tbl _