Patent GB-1388149-A (GB)
Title: Cosmetic compositions and methods comprising or employing glutathion derivatives
IPC: C07D213/70
Filed: 1972-09-19
Abstract: 1388149 Cosmetic compositions L'OREAL 19 Sept 1972 [20 Sept 1971] 43363/72 Heading A5B Compositions for counteracting the greasy appearance of hair and skin comprise a topically acceptable or orally administrable carrier and a compound of the formula: in which R' represents a hydrogen atom, or a -CONH 2  or -COA radical, wherein A represents an alkyl radical with 1 to 18 carbon atoms or an alkenyl radical with 2 to 18 carbon atoms and t is 1 or 2, such that: 1) when t = 1 R represents either: a linear or branched alkyl radical with 1 to 18 carbon atoms, an alkenyl radical with 3 to 18 carbon atoms, an alkyl radical with 2 to 4 carbon atoms substituted by one or two OH groups, a radical of the formula: or a radical of the formula: in which m is 1 or 2, R" represents an alkyl radical with 1 to 4 carbon atoms and B represents either the radical -(CH 2 ) 2 - or the radical a radical of the formula: in which R"' represents a -CONH 2  or COA radical, A being as defined above, a radical of the formula: in which n is 2 or 3 and R, represents a hydrogen atom, or a -CONH 2 , -COR@ or -SO 2 R 3  radical, R 2  being a hydrogen atom, an alkyl radical with 1 to 18 carbon atoms, an alkenyl radical with 2 to 18 carbon atoms, or a -CF 3  -CH 2 C 6 H 5  or a radical of the formula III: R 7  being a hydrogen atom, an alkyl radical with 1 to 4 carbon atoms an alkoxy radical with 1 to 4 carbon atoms or a halogen atom and R 3  being an alkyl radical with 1 to 4 carbon atoms or a radical of the formula III above, a radical of the formula -(CH 2 ) n -R 4 , in which p is 0, 1 or 2 and R, can represent a 1-naphthyl radical when p=0 or 1, a 2- naphthyl radical when p=0 or 1, a 2-thienyl radical when p=1, a 2-tetrahydrofuryl radical when p=1, a 2-furyl radical when p=1 and a 2-pyridyl radical, optionally substituted by a nitro group or an alkyl group with 1 to 4 carbon atoms, or a 2-pyridyl-N-oxide radical, when p=0, 1 or 2, or a radical of the formula: when p=0, 1 or 2 and in which: if q is 1, 2 or 3: R 5  can represent a hydrogen or halogen atom, an alkoxy radical with I to 5 carbon atoms or a branched or unbranched alkyl radical with up to 4 carbon atoms, and if q is 1 only: R 5  can also represent a dialkylamino radical, the alkyl radical having 1 to 3 carbon atoms, a phenoxy, amino, methylenedioxy, phenyl or alkylthio radical, the alkyl radical having 1 to 5 carbon atoms, an alkylsulphinyl radical, the alkyl radical having 1 to 5 carbon atoms, and a trifluoromethyl radical, or a --CH 2 -CH 2 - CH 2 -C 6 H 5 , -CH(C 6 H 5 ) 2 , -CH 2 -CH=CHC 6 H 5 , -CH(C 6 H 4 p-OCH 3 ) 2 , -C(CH 3 ) 2 (C 6 H 4 p -OCH 3 ) or -(CH 2 ) s -COR 6  radical in which s is an integer from 1 to 4 and R 6  is an -OH, morpholino, pyrrolidono, N-methyl-piperazino, -NH 2 , diethylamino, dimethylamino or 1, 2- dicarboxy-ethyl radical, 2) when t=2 R represents a radical of the formula: in which n is 1, 2 or 3, optionally substituted by 1 or 2 OH groups, a butenylene radical or a radical of the formula: The compositions may be in such forms as creams, lotions, hair dressing compositions including shampoos and permanent waving preparations, gels, dermatological blocks, aerosol foams, solutions, granules, pills, dragees and capsules all of which may contain conventional ingredients.