Patent SG-11201808621T-A (SG)
Title: Heterocyclic amides useful as protein modulators
Inventor: CHARNLEY ADAM KENNETH
IPC: C07D413/14
Filed: 2017-04-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111 0111010111 1011 0101110111111101111011# International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ...... ... WO 2017/175147 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (72) Inventors: CHARNLEY, Adam Kenneth; 1250 South C07D 405/14 (2006.01) COIF 9/09 (2006.01) Collegeville Road, Collegeville, PA 19426 (US). DARCY, CO7D 413/14 (2006.01) A61K 31/4184 (2006.01) Michael G.; 709 Swedeland Road, King of Prussia, PA CO7D 403/14 (2006.01) A61P 31/08 (2006.01) 19406 (US). DODSON, Jason W.; 709 Swedeland Road, CO7D 487/22 (2006.01) A61P 35/00 (2006.01) King of Prussia, PA 19406 (US). DONG, Xiaoyang; 1250 CO7D 493/10 (2006.01) A61P 37/00 (2006.01) South Collegeville Road, Collegeville, PA 19426 (US). CO7D 498/18 (2006.01) HUGHES, Terry V.; 1705 Glenn Lane, Blue Bell, PA (21) International Application Number: PCT/IB2017/051945 19422 (US). KANG, Jianxing; 1250 South Collegeville Road, Collegeville, PA 19426 (US). LEISTER, Lara Kathryn; 1250 South Collegeville Road, Collegeville, PA (22) International Filing Date: 19426 (US). LIAN, Yiqian; 1250 South Collegeville 5 April 2017 (05.04.2017) (25) Filing Language: English Road, Collegeville, PA 19426 (US). LI, Yue; 709 Swede- land Road, King of Prussia, PA 19406 (US). MEHL- MANN, John F.; 1250 South Collegeville Road, Col- (26) Publication Language: English legeville, PA 19426 (US). NEVINS, Neysa; 1250 Col- legeville Road, Collegeville, PA 19426 (US). RAMANJU- (30) Priority Data: LU, Joshi M.; 1250 South Collegeville Road, Collegeville, 62/319,358 7 April 2016 (07.04.2016) US PA 19426 (US). ROMANO, Joseph J.; 1250 Collegeville 62/461,301 21 February 2017 (21.02.2017) US Road, Collegeville, PA 19426 (US). WANG, Gren Z.; 62/461,975 22 February 2017 (22.02.2017) US 1250 Collegeville Road, Collegeville, PA 19426 (US). YE, (71) Applicant: GLAXOSMITHKLINE INTELLECTUAL Guosen; 1250 Collegeville Road, Collegeville, PA 19426 — PROPERTY DEVELOPMENT LIMITED [GB/GB]; (US). ZHANG, Daohua; 1250 South Collegeville Road, = 980 Great West Road, Brentford, Middlesex TW8 9GS Collegeville, PA 19426 (US). (GB). — [Continued on next page] = (54) Title: HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS R 4 R14 (57) : Disclosed are compounds having the formula (I-N), wherein q, r, s, A, B, C, R A1 , R A2 , R , R , R , R , R B1 B2 cl c2 3 , 12 4 , R, R, R 5 6 14 , R 15 N , R 16 , and R 17 , are as defined herein, or a tautomer = = — 3 I R \ NH ) N -.....,N thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof. = = '------N I 1 _ ) \ — — RA1 R ei 0 R16 = = Rci / = = (A) q (B)1 (C) s \ RB2 RA2 RC2 = 1-1 R 5 ....... ., ..-N \ NH > NI N I N K% ------ N ) \ 71- 1—I lin IN R6 0 R17 R16 (I-N) 1-1 IN 1-1 0 ei 0 WO 2017/175147 Al 1#11101113IIMEMEMOMOMMOIDIMOVOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, (84) DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) — of inventorship (Rule 4.17(iv)) Published: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, with international search report (Art. 21(3))