baber/WOPTO huggingface dataset:
Patent DE-69320187-T2 (DE)
Inventor: DANSEREAU SUSAN
IPC: C07F9/547
Filed: 1993-05-26
Granted: 1999-02-11
Abstract: The present invention relates to phosphonosulfonates and the pharmaceutically-acceptable salts and esters thereof, having the structure according to formula (I). The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism in humans or other mammals, including treating or preventing osteoporosis and arthritis, especially rheumatoid arthritis and osteoarthritis. This method comprises administering to a human or other mammal in need of such treatment of a safe and effective amount of a compound or composition of the present invention.
Patent DE-69326046-T2 (DE)
Inventor: CHIOU SHANG-JAW
IPC: C08J5/00
Filed: 1993-07-08
Granted: 2000-04-13
Abstract: A process for preparing large dimension emulsion polymer particles and the polymer products of the process are disclosed. In one embodiment, the invention provides particles having a high aspect ratio, having a shape described by a long axis and an intersecting short axis. These particles range in shape from egg-like, through rod-like, up to extended filaments. In another embodiment, the invention relates to large, nearly spherical emulsion polymer particles. <IMAGE>
Patent DE-69331069-T2 (DE)
Inventor: MAYER DAVID W
IPC: A61F2/00
Filed: 1993-11-23
Granted: 2002-07-04
Abstract: A body compatible stent is formed of multiple filaments arranged in at least two sets of oppositely directed helical windings interwoven with one another in a braided configuration. Each of the filaments is a composite including a central core and a case surrounding the core. In the more preferred version, the core is formed of a radiopaque and relatively ductile material, e.g. tantalum or platinum. The outer case is formed of a relatively resilient material, e.g. a cobalt/chromium based alloy. Favorable mechanical characteristics of the stent are determined by the case, while the core enables in vivo imaging of the stent. The composite filaments are formed by a drawn filled tubing process in which the core is inserted into a tubular case of a diameter substantially more than the intended final filament diameter. The composite filament is cold-worked in several steps to reduce its diameter, and annealed between successive cold working steps. After the final cold working step, the composite filament is formed into the desired shape and age hardened. Alternative composite filaments employ an intermediate barrier layer between the case and core, a biocompatible cover layer surrounding the case, and a radiopaque case surrounding a structural core.
Patent DE-69400654-T2 (DE)
Inventor: PETERS HENRICUS JOHANNES
IPC: B41F15/42
Filed: 1994-02-22
Granted: 1997-03-06
Abstract: A device for suspending a squeegee in a cylindrical screen (1) of a rotary screen printing machine, in which the cylindrical screen is accommodated with both ends in drive and support units, and in which the squeegee extends in the lengthwise direction inside the cylindrical screen, comprises two squeegee supports, each disposed near one of the drive and support units, and each provided with an accommodation opening for the accommodation of one end of the squeegee. At the side facing the inside of the cylindrical screen (1), one of the squeegee supports (10) is provided with a guide element (13) for guiding an end of a squeegee into the accommodation opening (12) when the squeegee is being mounted in the cylindrical screen. <IMAGE>
Patent DE-69407444-T2 (DE)
Inventor: AZKONA OLLACARIZQUETA MANUEL
IPC: B21D7/06
Filed: 1994-02-18
Granted: 1998-08-13
Abstract: Electrical apparatus for bending tubes (pipes), of the type of those using a transmission system consisting of a reducing-gear electric motor (gear motor) actuating, as the rotation element, a shaped shoe (block) or last, being characterised in that it is coaxial with the revolution element over which has been placed an end-of-travel cap with stationary limit-stop means which are angularly arranged so as to form a stop mechanism, during its rotation, with a peg (pin) of a rod sliding on the rotor (armature) of the apparatus which drives, by means of its movement, the displacement of the working control member (7) of the transmission system. <IMAGE>
Patent DE-69411394-T2 (DE)
Inventor: PROTO PASQUALE
IPC: A45D8/00
Filed: 1994-10-31
Granted: 1999-05-27
Abstract: A clip for use when colouring discrete hair strands comprises two elongate gripper members (1, 2) joined by a hinge (3) and including at their free ends means (5) for selectively connecting one gripper member to the other, and a strip of flexible impervious material (9) carried by each gripper member. The gripper members are preferably produced from a plastics material, the hinge comprising a resilient plastics strip joining one gripper member to the other.
Patent DE-69417625-T2 (DE)
Inventor: BARQ PHILIPPE
IPC: B29C65/78
Filed: 1994-05-31
Granted: 1999-12-30
Abstract: The invention relates to a device for holding in place on a tube, during a welding operation and during the consecutive cooling period, a heat-weldable connector which has the shape of half a cylinder and which contains at least one heating element for the purpose of welding on to the tube by a thermal method. This device is characterised in that it comprises a strap (9) which is made of a flexible substance and which is provided at each of its ends with a fastening means (10, 11) making it possible to fix it removably to the said heat-weldable connector (2) by passing around the said tube (3), at least one of the said fastening means including means for altering the distance between the said heat-weldable connector (2) and the corresponding end of the said strap (9). Application to tappings on mains intended for conveying fluid. <IMAGE>
Patent DE-69418339-T2 (DE)
Inventor: CAUSTON BRIAN EDWARD
IPC: A61K8/891
Filed: 1994-11-08
Granted: 1999-12-16
Abstract: PCT No. PCT/GB94/02447 Sec. 371 Date May 7, 1996 Sec. 102(e) Date May 7, 1996 PCT Filed Nov. 8, 1994 PCT Pub. No. WO95/13046 PCT Pub. Date May 18, 1995A water-insoluble porous cross-linked polymeric matrix contains an antiperspirant in its pores, the pores being interconnected to permit the antiperspirant to be leached therefrom with water, with zero order release without change in pore geometry. The pores may additionally contain one or more other materials such as deodorants, moisturizers, lubricants and perfumes. The matrix can be shaped for application to the skin. An antiperspirant dispenser can comprise a matrix of the invention with a water reservoir therefor.
Patent DE-69426892-T2 (DE)
Inventor: ST CLAIR RONALD
IPC: B65B9/02
Filed: 1994-12-30
Granted: 2001-07-26
Abstract: A method and apparatus for manufacturing mattresses, including the steps of forming a coil spring from wire, conditioning said coil spring to reduce stresses formed therein, placing said coil spring within pockets to create elongate strings of pocketed coil springs, attaching said elongate strings to create innerspring constructions.
Patent DE-69432076-T2 (DE)
Inventor: BENGTSSON INGA SIV
IPC: A61K31/4439
Filed: 1994-07-08
Granted: 2003-10-16
Abstract: PCT No. PCT/SE94/00681 Sec. 371 Date Sep. 27, 1994 Sec. 102(e) Date Sep. 27, 1994 PCT Filed Jul. 8, 1994 PCT Pub. No. WO95/01783 PCT Pub. Date Jan. 19, 1995A new oral pharmaceutical formulation containing a novel physical form of a magnesium salt of omeprazole, a method for the manufacture of such a formulation, and the use of such a formulation in medicine.
Patent DE-69510056-T2 (DE)
Inventor: PIANTELLI FRANCESCO
IPC: G21B3/00
Filed: 1995-01-27
Granted: 2000-02-03
Abstract: A process of energy generation and an energy generator by means of anharmonic stimulate fusion of hydrogen isotopes absorbed on metal comprising a charging step on a metallic core (1) of a quantity of hydrogen isotopes H and D; a heating step in which said core (1) is heated (9) to reach a temperature higher than Debye's temperature of the material composing the core; a startup step wherein a vibrational stress is produced with a rise time less than 0.1 seconds which activates a nuclear fusion of said hydrogen isotopes; a stationary step during which it is exchanged (3,5) the heat produced by the H+D nuclear fusion reaction which occurs in the core (1) because of a steady keeping of a coherent multimodal system of stationary oscillations.
Patent DE-69510460-T2 (DE)
Inventor: LE LEM GAEL
IPC: C07C231/02
Filed: 1995-09-20
Granted: 2000-01-13
Abstract: PCT No. PCT/FR95/01212 Sec. 371 Date Mar. 21, 1997 Sec. 102(e) Date Mar. 21, 1997 PCT Filed Sep. 20, 1995 PCT Pub. No. WO96/09280 PCT Pub. Date Mar. 28, 1996The invention relates to compounds of formula:   <IMAGE>    <IMAGE>   in which Ti, Vi, T'i and V'i with i=0, 1 or 2, represent O, COND or NDCO, D being H, alkyl or (poly)hydroxyalkyl; Qi and Q'i with i=0, 1 or 2, represent alkylene or (poly)hydroxyalkylene; Ari and Ar'i with i=1 or 2, represent   <IMAGE>   in which R, R3, R4 are COOH and R', R'3, R'4 are CONR'1R'2 or N(R'1)COR'2, R' and R'2 being H, alkyl or (poly)hydroxyalkyl such that R'1 and R'2 together comprise at least 4 hydroxyl groups, or Ri and R'i with i=nothing, 3 or 4 represent CONR'1R'2 or N(R'1)COR'2, R'1 and R'2 together comprising at least 6 hydroxyl groups, or else Ri and R'i with i=3 or 4 represent T-Q-V-Ar, T, Q and V being as defined above for Ti, Qi and Vi and Ar having formula II, and A is a biocompatible radical of molecular weight less than 1200 having two valences such as to give with To and T'o an amide or ether group.
Patent DE-69516085-T2 (DE)
Inventor: DICKSON DUDLEY TREVOR
IPC: F16L55/18
Filed: 1995-06-07
Granted: 2000-12-21
Abstract: A corrugated plastic service pipe 20 is inserted together with a flexible guide assembly 22 through an accessible end 11 of a steel service pipe 14, 10, which extends from the end 11 to a main 18. The flexible guide assembly 22 comprises a flexible guide element 24 and a flexible spring guide 26. The element 24 extends through a nose-piece 32 having an outer part secured to the pipe 20 and an inner part 36. The spring guide 26 carries a sensor 60 at its tip which emits a signal when the sensor enters the main 18. When the pipe 20 is correctly positioned fluid sealant 70 is injected into the space between the pipe 20 and the pipe 14, 10. When the sealant has solidified sufficiently, the guide assembly 22 is withdrawn through the pipe 20, the inner part 36 being separated from the outer part 34 to allow withdrawal of the spring guide 26.
Patent DE-69524773-T2 (DE)
Inventor: SCHMIDT-HANSEN HANS
IPC: F16L23/08
Filed: 1995-09-07
Granted: 2002-06-13
Abstract: PCT No. PCT/SE95/01001 Sec. 371 Date Mar. 5, 1997 Sec. 102(e) Date Mar. 5, 1997 PCT Filed Sep. 7, 1995 PCT Pub. No. WO96/07848 PCT Pub. Date Mar. 14, 1996A device for coupling two pipe sections comprises a clamping band of U-shaped cross-section with two inwardly directed flanges for encompassing end beads of the pipe sections which are to be coupled. The ends of the clamping band have cylindrical pockets each accommodating a cylindrical element which is rotatable about its own axis in the pocket. The clamping band is clamped by means of a threaded screw which is passed through an unthreaded hole in one cylindrical element and unthreaded holes in the ends of the clamping band, whereupon the screw is in threaded engagement with the other cylindrical element.
Patent DE-69526206-T2 (DE)
Inventor: WOLF F
IPC: A61K38/20
Filed: 1995-01-20
Granted: 2002-11-21
Abstract: The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed.
Patent DE-69534452-T2 (DE)
Inventor: NI JIAN
IPC: A61P19/10
Filed: 1995-12-19
Granted: 2006-06-22
Abstract: A human OAP polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide as an antiviral agent, for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation and for osteoporosis. Also disclosed are agonists and antagonists to the polypeptide of the present invention which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma osteopetrusis, osteoporosis and osteoblastoma. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
Patent DE-69606001-T2 (DE)
Inventor: BIGAY YVES
IPC: B23K35/00
Filed: 1996-10-03
Granted: 2000-06-08
Abstract: Two pieces of intermetallic compound such as TiAl are bonded together, or one such piece is coated or repaired, by mixing the corresponding metal powders to approximately the same formula as in said piece(s) and compacting an intermediate or coating section from the mixture, then placing the section between or in contact with the piece(s) and heating the assembly to reactively sinter the section and bond it to the piece(s) by diffusion. Pref. the heating involves a first sintering stage followed by bonding at a higher temp.
Patent DE-69606322-T2 (DE)
Inventor: FARTHING HOWARD JOHN
IPC: B67D7/42
Filed: 1996-11-21
Granted: 2000-08-10
Abstract: PCT No. PCT/GB96/02868 Sec. 371 Date May 20, 1998 Sec. 102(e) Date May 20, 1998 PCT Filed Nov. 21, 1996 PCT Pub. No. WO97/19015 PCT Pub. Date May 29, 1997A collar for fitting over at least a portion of the housing of a fuel delivery nozzle. The collar comprises a main body, an arrangement for securing the main body to the housing, and a collar portion shaped to mateably engage around a portion of the housing and arranged to engage the main body.
Patent DE-69700137-T2 (DE)
Inventor: RICHARD HERVE
IPC: A61K8/00
Filed: 1997-01-15
Granted: 1999-07-01
Abstract: Insoluble s-triazine compounds (I) of the following formula are new: in which R1, R1' and R1" are: where -R2 and R2' are 1-3C alkyl groups; -R3 is H, an 1-4C alkyl group, or a 1-4C alkoxy group; -R4 is a 1-12C alkyl group; -X1 is H or a phenyl group, possibly substituted by a halogen, a 1-4C alkyl group or a 1-4C alkoxy group. Also claimed is a composition (IV) to protect sensitive materials from UV radiation comprising (I). Also claimed is a method (V) of protecting sensitive materials from UV radiation comprising the application of (IV) to, or the incorporation of (IV) in, the sensitive material.
Patent DE-69702057-T2 (DE)
Inventor: NESBITT CHARLES
IPC: B60K5/02
Filed: 1997-06-05
Granted: 2000-11-09
Abstract: A motor vehicle power train includes an engine (26) mounted longitudinally in the vehicle adjacent one end, a change speed transmission (28) spaced from and drivably connected to the engine through an input propshaft (31) and a transfer transmission (29) mounted on the change speed transmission and drivably connected to a front differential through a front propshaft (34) and to a rear differential through a rear propshaft (35). The change speed transmission has an input shaft (39) to receive drive at one end from the engine and an output shaft (41) axially offset from the input shaft and having a drive output at the opposite end. The transfer transmission is arranged at the opposite end of the change speed transmission and includes a center differential (56) having differential output shafts (57, 58) drivably connected to the front and rear propshafts and axially offset from the input shaft and the change speed transmission output shaft.
Patent DE-69705740-T2 (DE)
Inventor: ANDRE JEAN-LUC
IPC: B60P7/08
Filed: 1997-12-09
Granted: 2002-05-23
Abstract: The flexible link is a securing strap (2) which rests on the tire (5) and is tightened with respect to two fixed points on a carrying structure (7) by which the ends of the strap are retained with fixing pieces. The surface in contact with the running tread comprises successive groups (25) of a plurality of transversal support elements (26) in the form of rollers with a central rod and widened ringed tips (28) and (29) forming contiguous rail wheels by which the strap rests on the tire. This invention is applicable in the field of transport when the load consists of road vehicles.
Patent DE-69707505-T2 (DE)
Inventor: MOONEY CHARLES
IPC: A61B17/00
Filed: 1997-11-21
Granted: 2002-06-13
Abstract: A multiple lumen access device for use in providing a single entry port into the human body for selectively introducing medical implements therethrough and for providing simultaneous auxiliary access into the body. The multiple lumen access device (10, 400, 500, 520, 550) includes a multiple lumen sheath (404, 506, 530) which may have an outer tube (12, 422) and structure defining a device lumen (30, 31, 130, 230, 330, 426, 574, 582, 586) located therein. The inner structure may be an inner tube (24, 124, 224, 324, 432). The outer tube and inner structure are located so as to define at least one auxiliary lumen (36, 37, 48, 49, 138, 140, 142, 236, 248, 336, 428, 584, 588) which may be located between the exterior surface of the inner tube and the interior surface of the outer tube. Embodiments include flexible inner tubes which can be flexed between relaxed and expanded/contracted positions wherein the relative cross-sectional areas of the device lumen and auxiliary lumens are varied. The access device further includes a valve (70, 418, 502, 514, 528, 532, 554) which provides sealing of the device lumen. The valve may be provided in a lumen junction housing (56, 402), or separate from the housing either permanently or removably connected with the device lumen. Alternatively, a multiple lumen sheath (560) may be passed through a valve (554) leading to a conventional introducer (564). The valve may also be molded separately as a rigid insert (418) and retained in a cavity (450) formed in a flexible junction housing. <IMAGE>
Patent DE-69709294-T2 (DE)
Inventor: BUCHY MICHEL
IPC: B21D13/06
Filed: 1997-11-10
Granted: 2002-08-08
Abstract: The continuous re-profiling machine consists of supporting bars (7) for the corrugated material, driven in a direction perpendicular to their lengthwise orientation, and re-profiling bars (2) connected to a rotating endless chain (11) and moved relative to it. It also has counter-forming bars (6) connected to a second rotating endless chain (16) and moved relative to it. The cross-sectional shape of the counter-form bars is complementary to that of the re-profiling bars, and the re-profiling and counter-form bars are located on either side of the layer of supporting bars (7) so that they face one another and move perpendicular to the plane of the supporting bars.
Patent DE-69717076-T2 (DE)
Inventor: TIFFIN DAVID
IPC: C07D491/10
Filed: 1997-01-06
Granted: 2003-07-17
Abstract: PCT No. PCT/GB97/00023 Sec. 371 Date Jul. 2, 1998 Sec. 102(e) Date Jul. 2, 1998 PCT Filed Jan. 6, 1997 PCT Pub. No. WO97/25330 PCT Pub. Date Jul. 17, 1997The subject invention concerns a process for the preparation of enantiomerically-enriched galanthamine from racemic galanthamine, and a process for increasing the enantiomeric excess of enantiomerically-enriched galanthamine, by direct crystallization of galanthamine salts.
Patent DE-69717167-T2 (DE)
Inventor: PRUSINER B
IPC: A61K38/00
Filed: 1997-04-15
Granted: 2003-07-24
Abstract: The invention includes deleting codon segments from DNA expressing a native protein (e.g., PrPSc) in order to obtain a shorter, soluble protein which mimics characteristics of an insoluble native (e.g., PrPSc) protein. Soluble proteins of the invention are characterized by: (1) having less amino acids than the full length native protein; (2) having a higher degree of solubility than the native protein; (3) retaining the basic biological characteristics of the native protein such as (a) not being subject to enzymatic digestion and (b) causing disease. Soluble proteins of the invention are obtained by providing a DNA sequence which encodes a native protein and systematically removing codons, making copies of the shortened versions of DNA which are then expressed to provide the shortened proteins. The shortened proteins are then tested for solubility. Soluble proteins are then further tested to confirm that they retain the biological characteristics of the native protein. The soluble form can also be created by adding amino acids, binding a hydrophilic moiety to the native protein or combinations of deleting, adding, and binding hydrophilic moieties to the protein.
Patent DE-69727379-T2 (DE)
Inventor: SHAFFER ROY
IPC: F16F9/30
Filed: 1997-05-23
Granted: 2004-11-04
Abstract: A method of and apparatus for damping vibration such as sound in a vibration generating device such as an appliance. A constraining layer and an adhering layer are provided. The adhering layer including a viscosity enhancing material such as a cellulose fiber, and an adhesive material. The constraining layer is adhered to a surface of an device with the adhering layer.
Patent DE-69727848-T2 (DE)
Inventor: KATO KEIGO
IPC: F16K11/07
Filed: 1997-01-13
Granted: 2005-03-24
Abstract: Disclosed are a spool valve which comprises: a shaft (1) having plural small diameter portions (2) formed at required intervals on the circumferential surface of the shaft; a pair of circular convex portions (3) having a diameter larger than the inner diameter of a collar (4), provided on the outer circumferential faces of each small diameter portion; and the collar (4) subjected to quenching processing, arranged between the circular convex portions (3) so that the side faces of the circular convex portions are in close contact with circular concave portions (6) formed at both ends of a center hole of the collar (4) or both side faces themselves of the collar (4), and a process for manufacturing the same. <IMAGE>
Patent DE-69732342-T2 (DE)
Inventor: TRANCHAND ALAIN
IPC: H02H3/22
Filed: 1997-12-10
Granted: 2005-12-22
Abstract: The motor (MO), which is continuous current, is fed through a dipole (SS). This dipole may comprise a number of circuits using transistors, resistors and capacitors as well as an integrated threshold circuit and a zener diode. The dipole is able to detect overcurrents which are not transient and to interrupt them and it uses filtering and memorisation circuits to suppress the effect of motor starting currents. Overcurrent detection is achieved by an integrated threshold circuit (CI) which produces an output voltage (S) when the voltage drop on a load carrying resistor (R2) becomes too great. The output voltage then blocks the power transistors (T1,T3,T4) reducing the motor current to virtually zero.
Patent DE-69734096-T2 (DE)
Inventor: CHANG MING-SHI
IPC: A61P3/10
Filed: 1997-01-02
Granted: 2006-06-29
Abstract: The present invention relates to a novel class of protein receptors, herein denominated "OB protein receptors" or "OB receptors", which are thought to selectively bind OB protein. As such, the novel OB protein receptor family is provided, as well as novel members of such family. Also provided are nucleic acids, vectors and host cells containing such nucleic acids, related antisense nucleic acids, molecules which selectively bind to the OB protein receptor, and related compositions of matter, such as OB receptor protein/OB protein complexes and pharmaceutical compositions. In other aspects, the present inventon relates to methods of using the above compositions, such as therapeutic and/or diagnostic methods, and methods for preparing OB receptor ligands.