Patent RU-2526173-C1 (RU)
Inventor: KESJAN GURGEN ABAVENOVICH
IPC: G01N33/53
Filed: 2013-03-28
Granted: 2014-08-20
Abstract: FIELD: medicine.SUBSTANCE: invention describes a method of predicting post-operative regeneration in patients with false joints of long tubular bones, which includes analysis of the patient's venous blood, analysis of results of its analysis with formulation of a prediction of post-operative regeneration by selected parameters; in the patient's blood plasma determined are: a level of content of diene conjugates (DC) and double bonds (DB) in blood plasma lipids, quantity of lipids in the patient's blood plasma, quantity of "acute phase" protein -ceruloplasmin, as well as the percent content of highly stable erythrocytes in the patient's blood; integral indices of change of condition of molecular-biological processes in the equilibrium system of lipid peroxidation (LP) of the patient's blood plasma and its antioxidant protection (AOP). A product of content of diene conjugates (DC) and double bonds (DB) in the patient's blood plasma lipids is chosen as a criterion of development of a disbalance in the "LP-AOP" system of the patient's blood plasma, then, in case if the measured parameter of content of double bonds (DB) constitutes (29.6-37)10M/mg of lipids, the measured parameter of content of diene conjugates (DK) constitutes (2.34-2.76)10conventional units, calculated by the results of measurements integral index in the form of DB×DC product constitutes (69.3-102.1)10conventional units, quantity of lipids in the patient's blood plasma constitutes 6.2-8.6 mg/ml, quantity of "acute phase" protein - ceruloplasmin in the patient's blood plasma constitutes 29.6-36.8 conventional units, and percent content of highly stable erythrocytes in the erythrocyte population in the patient's blood plasma constitutes (14.3-17.3)%, processes, accompanied by impairment of the structure of erythrocyte membranes with manifestation of retarded consolidation of an injured element of the musculoskeletal system with formation of a false joint, non-complicated by inflammatory processes, are predicted, and in case if the measured parameter of content of double bonds (DB) constitutes (41.6-49.4)10M/mg of lipids, the measured parameter of content of diene conjugates (DC) constitutes (3.16-3.54)10conventional units, calculated by the results of measurements integral index in the form of DB×DC product constitutes (131.5-174.9)10conventional units, quantity of lipids in the patient's blood plasma constitutes 2.6-5.8 mg/ml, quantity of "acute phase" protein - ceruloplasmin in the patient's blood plasma constitutes 41.6-49.4 conventional units, and percent content of highly stable erythrocytes in the erythrocyte population in the patient's blood plasma constitutes (4.6-6.0)%, a process of impairment of the structure of erythrocyte membranes with manifestation of retarded consolidation of the injured element of the musculoskeletal system element with formation of a complicated with suppuration false joint is predicted.EFFECT: considerable increase of efficiency, self-descriptiveness, and objectivity of prediction in the patients with false joints of long tubular bones.2 cl, 4 ex