baber/WOPTO huggingface dataset:
Patent CA-3017551-A1 (CA)
Title: 3d-tissue culture based method to assess mitochondrial impairment
Inventor: KELM JENS
IPC: G01N33/50
Filed: 2017-03-14
Abstract: The present invention relates to a method and/or assay for the assessment of the metabolic effect of a candidate compound. The method and/or assay comprises exposing one or more 3- dimensional cell culture or tissue to one or more candidate compounds, and measuring, in at least one 3-dimensional cell culture or tissue, the effect of such exposure on the 3-dimensional cell culture or tissue-specific respiration rate (MTSRR).
Patent CA-3019018-A1 (CA)
Inventor: KILIAN GERD
IPC: H04L27/26
Filed: 2016-03-31
Abstract: Embodiments provide a receiver comprising a receiving unit and a synchronization unit. The receiving unit is configured to receive a data packet comprising a pilot sequence. The synchronization unit is configured to separately correlate the pilot sequence with at least two partial reference sequences corresponding to a reference sequence for the pilot sequence of the data packet, in order to obtain a partial correlation result for each of the at least two partial reference sequences, wherein the synchronization unit is configured to non-coherently add the partial correlation results in order to obtain a coarse correlation result for the data packet.
Patent CA-3020363-A1 (CA)
Inventor: BERGQVIST MATTIAS
IPC: C08K3/04
Filed: 2017-03-30
Abstract: A crosslinked polymer composition based on a plastomer, which is suitable for producing at least one layer of cable accessories like cable joints, bushings or terminations; its use for preparing such a layer and the cable accessory comprising the composition.
Patent CA-3021690-A1 (CA)
Title: Methodes et compositions permettant de modifier la composition du microbiome de la peau a l'aide de melanges complexes de souches bacteriennes
Inventor: PATZOLD BERNHARD
IPC: C12Q1/00
Filed: 2016-04-20
Abstract: Des aspects de l'invention concernent des compositions comprenant une ou plusieurs souches bactériennes vivantes destinées à une administration topique sur la peau, les une ou plusieurs souches bactériennes vivantes étant des souches bactériennes Propionibacterium acnes (P. acnes), et des procédés d'utilisation.
Patent CA-3021931-A1 (CA)
Title: Pipe forming method
Inventor: ROBERTS RICHARD DAMON GOODMAN
IPC: B29C70/32
Filed: 2016-04-28
Abstract: A method for forming a composite fluid conduit comprises providing an inner pipe (2) having a variation in cross-section between at least two different longitudinal sections thereof, and applying a fibre reinforced composite material (30) to the inner pipe (2). In some disclosed examples the variation in cross section may be provided intermediate opposing ends of the inner pipe (2). In other disclosed examples the variation in cross section may be provided at an end region of the inner pipe (2).
Patent CA-3022108-A1 (CA)
Title: System for reducing noise in a hydraulic fracturing fleet
Inventor: OEHRING JARED
IPC: G10K11/16
Filed: 2016-01-14
Abstract: Noise generated by a hydraulic fracturing system is abated by locating noise reduction equipment at strategic locations, and also by routing inlet and exit air along designated paths. Noise insulation panels are disposed around trailer mounted machinery to attenuate and redirect the noise generated by the machinery. The panels extend a distance above the machinery so that the noise is directed upward and away from operations personnel proximate the machinery. Air handling equipment having air inlets and exits that are formed to reduce turbulence, and thus noise, as well as redirect the flow of air to attenuate noise generated by its flow within the inlets and exits.
Patent CA-3022438-A1 (CA)
Inventor: PALUSHI JETMIR
IPC: A61B18/04
Filed: 2018-10-29
Abstract: A surgical instrument includes an elongate body configured to be inserted through the nasal cavity of a patient, and a plurality of electrodes spaced circumferentially about an exterior of the elongate body. The electrodes may be arranged at a distal end of the elongate body, and are configured to deliver bipolar RF energy to tissue for sealing the tissue. The elongate body may be in the form of a shaft having a lumen configured to draw fluid proximally through the surgical instrument with suction.
Patent CA-3025117-A1 (CA)
Inventor: BEISSON FREDERIC
IPC: C12N9/02
Filed: 2017-05-19
Abstract: The present invention relates to the identification of a new class of fatty acid decarboxylases and its uses, in particular for producing alkanes/alkenes from fatty acids.
Patent CA-3029801-A1 (CA)
Title: Housing element for a writing instrument and writing instrument
Inventor: MOECK GERHARD
IPC: B25F1/00
Filed: 2019-01-11
Abstract: A housing element (1) for a writing instrument comprises a hollow, sleeve-shaped, elongated base body (2) that has an opening (8) for receiving the writing instrument or a pencil lead of the writing instrument at a first longitudinal end (6) and which has a second longitudinal end (14), which is opposite the first longitudinal end (6) and has a retaining recess (16) that is formed with a polygonal cross section for directly or indirectly retaining a bit (18) in a rotationally fixed manner.
Patent CA-3031737-A1 (CA)
Title: Efficacy of anti-hla-dr antibody drug conjugate immu-140 (hl243-cl2a-sn-38) in hla-dr positive cancers
Inventor: GOVINDAN SERENGULAM V
IPC: A61K39/395
Filed: 2017-08-04
Abstract: The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-HLA-DR antibody or antigen-binding antibody fragment. The immunoconjugate may be administered at a dosage of between 3 mg/kg and 18 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg, more preferably 8, 10 or 12 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. The methods and compositions are particularly useful for treating AML, ALL or multiple myeloma.
Patent CA-3037230-A1 (CA)
Title: Diagnostic anti-pd-l1 antibody and use thereof
Inventor: WILM CLAUDIA
IPC: C07K16/28
Filed: 2017-09-20
Abstract: The present invention provides for an antibody or antigen-binding fragment thereof which binds to an epitope within human PD-L1 with high specificity and reproducibility. The inventive antibody or antigen-binding fragment thereof may be used in assessing PD-L1 expression in tissue samples to aid in patient stratification. The present invention further provides methods of producing the inventive antibody.
Patent CA-3038849-A1 (CA)
Inventor: VRZIC SOPHIE
IPC: H04W4/00
Filed: 2017-09-29
Abstract: Methods and systems in which a UE can establish and maintain a data connection to a plurality of Radio Access Nodes for the creation of redundant data links is disclosed. Methods of implementing packet duplication as well as methods of determining when to activate or deactivate packet duplication are also disclosed.
Patent CA-3040225-A1 (CA)
Inventor: FRUEH KLAUS
IPC: A61P35/00
Filed: 2011-05-16
Abstract: Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.
Patent CA-3041704-A1 (CA)
Title: Spoonable smoothie and methods of production thereof
Inventor: GREGG-ALBERS JULIA LEE
IPC: A23C9/133
Filed: 2019-04-30
Abstract: Disclosed is a spoonable smoothie with fibrous, non-chalky, non-gritty texture.  The spoonable smoothie has more than 34% by weight of a combination of fruit and vegetable sources, a texturant, a protein source, a vitamin source, and a mineral source.  In some embodiments, the spoonable smoothie may be produced via high-pressure processing or thermal processing. In some embodiments in which high-pressure processing is employed, acid whey may be used to help obtain the non-chalky, non-gritty texture. In other embodiments in which thermal processing is employed, order of ingredients may be used to help obtain the non-chalky, non-gritty texture. In those thermally processed embodiments, the texturant and the protein source may be separately hydrated to control the competition for water absorption between the texturant and the protein source.
Patent CA-3043357-A1 (CA)
Title: Conveying device and method for mounting a cable conduit on a conveying device
Inventor: BINDER ARTHUR
IPC: H02G3/30
Filed: 2017-10-02
Abstract: The invention relates to a conveying device (1) for conveying containers (5) or container closures (6) and to a method for mounting a cable conduit (30; 300) on a conveying device (1). The conveying device (1) has a conveying element (11, 12; 19) for making contact with at least one part of the containers (5) or container closures (6), at least in some sections or temporarily, while they are conveyed in a predefined conveying direction (TR), the conveying element (11, 12; 19) being supported on a frame (10), and at least one cable conduit holder (20; 200; 2000) for holding a cable conduit (30; 300), wherein the at least one cable conduit holder (20; 200; 2000) is designed to mount the cable conduit holder (20; 200; 2000) on the conveying device (1) without tools and to accommodate the cable conduit (30; 300) without tools.
Patent CA-3044659-A1 (CA)
Title: Prostate specific membrane antigen binding protein
Inventor: BAEUERLE PATRICK
IPC: C07K16/46
Filed: 2017-11-22
Abstract: Disclosed herein are PSMA binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins comprising a PSMA binding protein according to the instant disclosure. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are further provided.
Patent CA-3046247-A1 (CA)
Title: Data platform for automated data extraction, transformation, and/or loading
Inventor: SUNDARARAMAN ARUN
IPC: H04L12/16
Filed: 2019-06-12
Abstract: A data platform may receive data files from an electronic data interchange (EDI). The data files may be received in multiple different data formats. The data platform may convert the data files to a common data format, extract data elements from the data files converted to the common data format, and assign the data elements extracted from the data files to file identifiers. The data platform may assign the data elements extracted from the data files to attribute identifiers that identify types of data represented by the data elements, aggregate the data elements to create a standardized data set, and map the data elements in the standardized data set to functions. The data platform may generate values based on mapping the data elements to the functions, determine a metric based on combining the values according to a metric definition, and post the metric to the EDI for consumption.
Patent CA-3046716-A1 (CA)
Inventor: ZENG CHENGUANG
IPC: A61L31/06
Filed: 2017-12-14
Abstract: A high-strength absorbable internal fixation bone screw for fractures. The bone screw is made of a degradable oriented polylactic acid section. A raw material for the oriented polylactic acid section is a poly(L-lactic acid). The specific optical rotation of the poly(L-lactic acid) is -155° to -160°. The section is made of the poly(L-lactic acid), and the process comprises: making a billet, orientation strengthening, and quenching, in that order. The method for making the billet is plastic injection molding. The method for orientation strengthening is forging press or extrusion. The section is turned, finely milled, or directly molded into the bone screw. The bone screw has high strength and a low rate of mechanical strength loss, ensures mechanical support during bone healing and sufficient healing time for an injured bone, has good biocompatibility, and can be degraded and absorbed.
Patent CA-3047991-A1 (CA)
Inventor: QI CHAO
IPC: A61P37/00
Filed: 2017-12-21
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
Patent CA-3050160-A1 (CA)
Title: Fuel-soluble synergistic cleaning mixture for high pressure gasoline engines
Inventor: SHANAHAN CHARLES
IPC: F02B77/04
Filed: 2019-07-19
Abstract: The present disclosure relates to methods and fuel compositions for reducing fuel injector deposits in gasoline engines operated at high fuel pressures. The fuel compositions include hydrocarbons boiling in the gasoline range and a synergistic fuel injector cleaning mixture.
Patent CA-3055654-A1 (CA)
Inventor: GLINER VADIM
IPC: A61B34/20
Filed: 2019-09-17
Abstract: A method includes transmitting electrical signals between one or more pairs of body-surface electrodes attached to a body of a patient. Electrical potentials resulting from the transmitted electrical signals are acquired by an outer-facing electrode and an inner-facing electrode of a medical probe inserted in an organ of the patient. A proximity of the medical probe to surface tissue of the organ is estimated based on the electrical potentials acquired by the outer-facing electrode. A position of the medical probe within the organ is estimated based on the electrical potentials acquired by the inner-facing electrode.
Patent CA-3056359-A1 (CA)
Title: System and method for intent based traffic management
Inventor: SRIDHAR KAMAKSHI
IPC: H04L47/22
Filed: 2019-09-23
Abstract: A system and a method for traffic management on a network. The method including:  determining a desired outcome for a network operator's traffic; determining a set of classes for a traffic flow through a link; determining a minimum and target bandwidth for each class in the set of class based on the desired outcome; measure user score and bandwidth use for each class; allocate a bandwidth per class based on the minimum and target bandwidth and measured user score; and shape the traffic flow to the allocated bandwidth.
Patent CA-3056928-A1 (CA)
Title: System and method for forecasting snowfall probability distributions
Inventor: DEPODWIN DAN
IPC: G01W1/14
Filed: 2018-03-30
Abstract: Currently available weather forecasts, which include a specific snowfall accumulation or range, do not convey the probability that snowfall will be within the forecasted snowfall accumulation range, probabilities of other snowfall accumulation amounts, or a forecaster's level of confidence. A snowfall probability distribution forecasting system is disclosed that uses a rules-based process to leverage third party weather forecasts, including members of ensemble forecasts, to generate snowfall probability distributions forecasting the most likely snowfall accumulation range, the probability that snowfall accumulation will be within the most likely snowfall accumulation range, and probabilities that snowfall accumulation will be outside of the most likely snowfall accumulation range. To ensure consistency with the deterministic forecast, the snowfall probability distribution may be shifted based on a deterministic forecast. Because third party weather forecasts can produce a non-normal distribution of snowfall accumulation forecasts, the snowfall probability distribution may be normalized.
Patent CA-3058847-A1 (CA)
Title: Device for sequentially introducing additives in a polymer granulate and use of the device
Inventor: GINSTER MATTHIAS
IPC: B01F7/08
Filed: 2019-01-30
Abstract: The invention relates to a device for the successive introduction of additives into a polymer granulate and use of the device for mixing the polymer granulates with the additives. The device consists of a mixer with a housing which contains at least one mixer shaft with non-continuous conveying moulded parts which are secured thereto in a helical arrangement and which are rotated by a drive for transport. The mixer has an inlet for the polymer granulate to be mixed in the housing, and a plurality of successive inlets for the additive and outlets for the polymer granulate mixed with the additive, and each inlet for the additive follows an outlet for the polymer granulate mixed with the additive follows so that two or more mixing zones are formed in the mixer. One section with a continuous conveyor screw is arranged between at least two mixing zones on the surface of the mixing shafts instead of the non-continuous conveying moulded parts, this section being impermeable to returning solids from the following mixing zone.
Patent CA-3061129-A1 (CA)
Title: Reduced arc windshield wiper system for a vehicle
Inventor: SHEPHERD RICHARD
IPC: B60S1/34
Filed: 2018-03-30
Abstract: A windshield wiper system (100) includes a pivoting wiper arm (110); a wiper blade (120) for wiping a surface (102); and a connector assembly (128) coupling the pivoting wiper arm (110) to the wiper blade (120), the connector assembly (128) comprising a gear drive (130) including at least one drive gear (132) and at least one positioning cog (136), wherein the gear drive (130) rotates the wiper blade (120) based on an angular position of the pivoting wiper arm (110) such that an arc of a motion path (320) of the wiper blade (120) is reduced.
Patent CA-3062388-A1 (CA)
Inventor: MERK DANIEL
IPC: A61P1/16
Filed: 2018-05-24
Abstract: La présente invention concerne de nouveaux modulateurs doubles du récepteur farnésoïde X (FXR) et de l'époxyde hydrolase soluble (sEH). Les modulateurs de l'invention ont été conçus pour fournir des composés qui abritent une double activité en tant qu'agonistes de FXR et inhibiteurs (antagonistes) de sEH. L'invention concerne également des méthodes de traitement de sujets souffrant de maladies associées à FXR et sEH, tels que des troubles métaboliques, en particulier une stéatose hépatique non alcoolique ou une stéatohépatite non alcoolique (NASH).
Patent CA-3068092-A1 (CA)
Title: Crushing tool for a roll crusher
Inventor: IRMAK BARIS
IPC: B02C4/30
Filed: 2018-06-20
Abstract: The present invention relates to a crushing tool (12) for attachment to a crushing roller (10) of a roll crusher, comprising a fastening segment (14), which can be connected to the crushing roller (10), and a wear segment (16) that is connected to the fastening segment, the wear segment (16) being made of a chromium steel.
Patent CA-3068292-A1 (CA)
Title: Clostridial neurotoxin formulations and use
Inventor: ABEL KENTON
IPC: A61K39/08
Filed: 2018-06-26
Abstract: Disclosed herein are compositions and methods for use in neurotoxin treatments.
Patent CA-3068852-A1 (CA)
Title: Nouveaux peptides et combinaison de peptides a utiliser dans l'immunotherapie du cancer du poumon, y compris le cpnpc, le cppc et d'autres cancers
Inventor: FRITSCHE JENS
IPC: C07K14/47
Filed: 2018-07-03
Abstract: La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules destinés à être utilisés dans des méthodes immunothérapeutiques. En particulier, la présente invention concerne l'immunothérapie du cancer. La présente invention concerne, en outre, des épitopes peptidiques des lymphocytes T associés à une tumeur, seuls ou en combinaison avec d'autres peptides associés à une tumeur, qui peuvent, par exemple, servir de principes actifs pharmaceutiques pour des compositions vaccinales qui stimulent des réponses immunitaires antitumorales, ou pour stimuler des lymphocytes T ex vivo et les transférer aux patients. Des peptides liés à des molécules du complexe majeur d'histocompatibilité (CMH), ou des peptides en tant que tels, peuvent également être des cibles d'anticorps, des récepteurs des lymphocytes T solubles et d'autres molécules de liaison.
Patent CA-3069794-A1 (CA)
Title: Radio-wave detection device
Inventor: YAMADA TETSUTARO
IPC: G01S7/38
Filed: 2017-07-28
Abstract: A device incudes: a prediction unit for predicting a feature amount that is likely to be extracted in the future by a feature amount extracting unit using a prediction model of a feature amount; and a hypothesis generation unit for generating a hypothesis that assumes a transmission source of a radio wave detected by a reception unit using a plurality of feature amounts extracted by the feature amount extracting unit and the feature amount predicted by the prediction unit.
Patent CA-3071225-A1 (CA)
Title: Apparatuses, methods and systems for persisting values in a computing environment
Inventor: KOHN DAVID
IPC: G06F9/448
Filed: 2018-08-07
Abstract: The present disclosure is directed to persisting values in a computing environment, particularly using computer programs that are configured to run on a virtual machine. An illustrative method includes first launching a computer program, preferably within the environment of a virtual machine. The method further includes loading a plurality of classes associated with the computer program into memory by way of a specially configured class loader. This class loader is configured to scan at least one class of classes loaded into memory for at least one persistence-annotated field within that class.  The specially configured class loader is further configured to write byte code into a class that contains the at least one persistence-annotated field. The byte code that is added to the class is configured to cause a first object that is later instantiated from the at least one class to have the persistence-annotated field.
Patent CA-3073009-A1 (CA)
Title: Customized ophthalmic surgical profiles
Inventor: HEGEDUS IMRE
IPC: A61F9/008
Filed: 2018-10-04
Abstract: A customized surgical profile is validated for execution on a surgical system. In some aspects, a customized ophthalmic surgical profile, which includes a surgical pattern and at least one parameter associated with the surgical pattern, is obtained. A pattern definition file executable by a laser-based ophthalmic surgical system is generated based on the customized ophthalmic surgical profile. Execution of the customized ophthalmic surgical profile on the laser-based ophthalmic surgical system is simulated based on the pattern definition file, and the pattern definition file is validated based on an output of the simulation.
Patent CA-3073802-A1 (CA)
Inventor: VAYA JACOB
IPC: C07C229/10
Filed: 2018-08-22
Abstract: The present invention relates to lyso-diacylglyceryltrimethylhomoserine (lyso- DGTS) or derivatives thereof for use in the treatment of atherosclerotic cardiovascular disease, and further provides particular such lyso-DGTS derivatives.