Patent GB-436791-A (GB)
Title: Method of producing therapeutically active preparations
IPC: C07D487/22
Filed: 1934-04-13
Abstract: Products useful as tonics are obtained by treating crude or purified chlorophyll, or porphins or like complex organic compounds derived therefrom, with reagents yielding ions of both copper and iron.  The reaction may be effected in a solvent for at least one of the reagents, and the products may then be filtered and washed, e.g. with dilute acid and alcohol.  In an example, an alcoholic chlorophyll solution is treated with a solution of ferric chloride and copper sulphate acidified with hydrochloric acid; the mixture is heated and then filtered, a precipitate containing 2 per cent of iron and 2,5 per cent of copper being obtained; a similar product is obtainable from water-soluble commercial chlorophyll.  The Specification as open to inspection under Sect. 91 describes the manufacture of similar products by treating chlorophyll or its derivatives or compounds with compounds of copper or iron.  The following examples are given: (1) an alcoholic chlorophyll solution is warmed with a solution of copper acetate acidified with acetic acid; a precipitate containing 6--10 per cent of copper is obtained; a similar product is obtainable from water-soluble commercial chlorophyll; (2) an alcoholic chlorophyll solution is warmed with aqueous copper sulphate in the presence of hydrochloric acid; a precipitate containing about 4 per cent of copper is obtained.  This subject-matter does not appear in the Specification as accepted.ALSO:Products useful as tonics are obtained by treating crude or purified chlorophyll, or porphins or like complex organic compounds derived therefrom, with reagents yielding ions of both copper and iron.  The reaction may be effected in a solvent for at least one of the reagents, and the products may then be filtered and washed, e.g. with dilute acid and alcohol.  The purified products may then be dispersed in an inert liquid such as water or an oil, e.g. by treatment in a colloid mill and/or with the addition of an emulsifying agent such as gum arabic or gelatin; the products may also be dispersed in a fat with the aid of lecithin as a dispersing agent.  Alternatively, dispersions of the crude products may be obtained by adding an emulsifying agent to the reaction mixture.  In an example, an alcoholic chlorophyll solution is treated with a solution of ferric chloride and copper sulphate acidified with hydrochloric acid; the mixture is heated p  and then filtered, a precipitate containing 2 per cent of iron and 2,5 per cent of copper being obtained; a similar product is obtainable from watersoluble commercial chlorophyll.  The Specification as open to inspection under Sect. 91 describes the manufacture of similar products by treating chlorophyll or its derivatives or compounds with compounds of copper or iron.  The following examples are given: (1) an alcoholic chlorophyll solution is warmed with a solution of copper acetate acidified with acetic acid; a precipitate containing 6-10 per cent of copper is obtained; a similar product is obtainable from water-soluble commercial chlorophyll; (2) an alcoholic chlorophyll solution is warmed with aqueous copper sulphate in the presence of hydrochloric acid; a precipitate containing about 4 per cent of copper is obtained.  This subject-matter does not appear in the Specification as accepted.