baber/WOPTO huggingface dataset:
Patent JP-3723589-B2 (JP)
IPC: C07D261/18
Filed: 1994-09-29
Granted: 2005-12-07
Abstract: The compounds of formula (I): <IMAGE>  [in which   R1 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms;   R2 represents a cycloalkyl group containing 3 to 6 carbon atoms; R4 represents a halogen atom, a nitrile group, a nitro group, an -SCH3 group, a C1-6 alkylcarbonyl group, a C3-6 cycloalkylcarbonyl group, a -CX3 group, a -WCX3 group, a -(CH2)nCX3 group, a -(CX2)n CX3 group, a -W(CX2)nCX3 group or a -W(CH2)nCX3 group, in which X represents a halogen atom, W represents an oxygen or sulphur atom and n represents 1, 2 or 3; and R5 represents a hydrogen atom, an alkyl group containing 1 to 3 carbon atoms or a cycloalkyl group containing 3 to 6 carbon atoms; provided that, if R5 represents a hydrogen atom, R4 does not represent an -SCH3 or -CF3 group]; and their salts have an anti-proliferative, anti-inflammatory and anti-tumour activity. A description is also given of processes for their preparation, of the compositions which contain them and of their use in therapeutics.
Patent JP-H0641465-B2 (JP)
Inventor: ANDORIYUU CHIYAARUZU BUREISUTE
IPC: C07D417/12
Filed: 1988-10-26
Abstract: A series of novel oxyethyl derivatives of certain select enolic oxicam compounds are disclosed, including certain novel oxyethyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (piroxicam). These particular compounds are useful in therapy as prodrug forms of the known anti-inflammatory and analgesic oxicams. Typical and preferred member compounds include 4-(2-hydroxyethyloxy)-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3- carboxamid e 1,1-dioxide, 4-(2-hydroxyethyloxy)-2-methyl-N-(6-methyl-2-pyridinyl)-2H-1,2-benzoth iazine-Y# 3-carboxamide 1,1-dioxide and N-[1-(2-hydroxyethyl)-2-pyridinium]-2-methyl-2H-1,2-benzothiazine-3-ca rboxamide 1,1-dioxide 4-enolate. Methods for preparing these compounds from known starting materials are provided.
Patent JP-H0570237-B2 (JP)
Inventor: INASAWA KATSUZUMI
IPC: G11B20/10
Filed: 1984-12-24
Abstract: 57 In a recording/reproducing apparatus, a program identifying number is recorded in a beginning portion of each of a sequence of programs recorded on a record medium (2) during a first recording operation, and a program start signal is recorded in a beginning portion of each program recorded in a second recording operation and thereafter. Subsequently, in a renumbering operation, each of the recorded program identifying numbers and/or program start signals is detected, with high speed movement of the record medium (2) therebetween, and the previously existing recorded program identifying numbers and/or program start signals are replaced by a properly ordered sequence of program identifying numbers on the record medium (2).
Patent JP-H0651171-B2 (JP)
IPC: B05D3/10
Filed: 1990-10-15
Abstract: Organic composite coated steel strips having improved corrosion resistance, weldability and coating adherence are obtained when an organic composite layer is applied to a chromate layer on a zinc or zinc base alloy plated steel substrate. The chromate layer containing up to 70% of Cr<6><+> based on the total chromium weight is coated in a weight of 5 to 500 mg/m<2> of Cr. The organic composite layer is formed to a dry weight of 0.2 to 3.0 g/m<2> from a coating composition comprising (A) a silica sol having silica dispersed in an organic solvent with a water content of up to 3.0%, the silica having an organic deposit on its surface in an amount of up to 5.0% of C based on the total silica weight, the silica having an average particle size of 0.05 to 3.0  mu m and a specific surface area of 50 to 800 m<2>/g, and (B) an organic resin binder having a number average molecular weight of at least 2,000. The coated strips are suitable for use as automobile bodies by press forming.
Patent JP-4110347-B2 (JP)
IPC: A61K31/513
Filed: 1999-11-05
Granted: 2008-07-02
Abstract: The present invention provides:   an anti-HIV composition comprising at least one member selected from the group consisting of trifluridine and derivatives thereof, and a pharmaceutically acceptable carrier; an anti-HIV composition comprising (a) at least one member selected from the group consisting of trifluridine and derivatives thereof, (b) a thymidine phosphorylase inhibitor, and a pharmaceutically acceptable carrier; and a composition for potentiating the anti-HIV activity of trifluridine and derivatives thereof, comprising a thymidine phosphorylase inhibitor and a pharmaceutically acceptable carrier.
Patent JP-2506866-B2 (JP)
IPC: A61K31/19
Filed: 1987-12-16
Granted: 1996-06-12
Abstract: To enrich in biologically active polyunsaturated fatty acids a fatty substance of plant or animal origin which contains these, an inclusion complex of the fatty acids is formed with a complexant in solution and the solution is cooled by being passed through a line containing 1 to 5 scraped-surface heat exchangers, and an enriched fraction is then collected in the liquid phase. 
<??>The enriched fractions, optionally combined with glycerol and converted into a form which is appropriate to their use, can constitute nutrient, cosmetic, dermatological or pharmaceutical products or may be used as a starting material in the synthesis of dihomo-gamma-linolenic acid.
Patent JP-4491102-B2 (JP)
IPC: B29C35/02
Filed: 1999-11-18
Granted: 2010-06-30
Abstract: A vulcanizing mold for a pneumatic tire has two crowns for the tire rims. Each crown has axial parting lines extending out from the center of the mold and two axially adjacent annular sections supporting the tire. One section supports the rim when the tire is filled with a vulcanizing fluid. The second section ensures the mold is fluid tight. An Independent claim is included for the following: (a) vulcanizing a tire using a mold as above by placing the tire on one of the crowns and bringing the other crown into contact. The tire is made to conform to the shape of the mold and vulcanized by directly contacting the tire interior with a vulcanizing fluid. Preferred Features: The second annular section in axial section has a cylindrical section, a circumferential groove 0.5 - 4 mm deep and an annular section. The mold has a third section at 5 degrees to the mold axis and which is an extension of the first annular section.
Patent JP-2664089-B2 (JP)
IPC: H01R24/38
Filed: 1988-12-12
Granted: 1997-10-15
Abstract: PCT No. PCT/EP88/01142 Sec. 371 Date Nov. 22, 1991 Sec. 102(e) Date Nov. 22, 1991 PCT Filed Dec. 12, 1988 PCT Pub. No. WO89/06057 PCT Pub. Date Jun. 29, 1989.A connecting arrangement in which a connector and a mating element are connectable to a cable which has at least one electrically conducting core. This core is surrounded by a light-transmitting electrical insulating layer. The connector and mating element each have at least one electrical contact and one optical contact, through which the connector and the mating element are optically coupled for light transmission at a location where the insulating layer lies against the cable. The connector and mating element conduct both electrical and optical signals.
Patent JP-3224540-B2 (JP)
IPC: G01N21/35
Filed: 1992-01-29
Granted: 2001-10-29
Abstract: To determine glucose or other constituents of the human or animal body, a stabilized near-infrared radiation beam (D) containing two alternating wavelengths that have approximately equal extinction coefficients in the tissue, is directed onto the sample area (18), the transmitted signal (E) alternating component is zeroed by tuning one of the wavelengths, the extracellular-to-intracellular fluid ratio of the tissue is changed by exerting varying mechanical pressure on the tissue, or the ratio is allowed to change as a result of the natural pulsation. The alternating component of the transmitted beam power is measured in the changed fluid ratio state. The amplitude of the alternating-current (AC) signal given by the detector (19), is taken to represent glucose concentration or the difference from a preset reference concentration.
Patent JP-H0737443-B2 (JP)
IPC: A61P19/10
Filed: 1990-02-16
Abstract: The invention provides a new vitamin D2 compound, 1 alpha -hydroxy-24-epi-vitamin D2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intestinal calcium transport and little or no activity in inducing bone calcium mobilization or the differentiation of undifferentiated cells in culture, thereby evincing utility in the treatment of diseases characterized by loss of bone mass.
Patent JP-3337686-B2 (JP)
IPC: G04G99/00
Filed: 1992-09-03
Granted: 2002-10-21
Abstract: A programmable clock includes a memory for storing times, dates and messages for subsequent read-out and display in providing a reminder of a birthday, anniversary, doctor's appointment, meeting, etc. The clock is adapted for prominent display by mounting to a wall or other support structure and provides a user with a visual display of stored reminder messages, as well as an indication of the content of the reminder message, over a given future time period, i.e., all stored reminder messages for today, tomorrow, or some other selected day in the future. The reminder clock also includes a speaker and an audio recorder for providing a reminder message in the user's own voice, as well as a printer for providing more extensive reminder messages as well as a list of all stored reminder messages. The reminder clock makes use of any one of several analog and combined analog and digital time displays which are easily read and understood, including a display presenting an analog representation of hours and a digital display of minutes. Various audio and/or video alarms are provided to indicate the read-out and display of a reminder message. An electronic pendulum is provided to indicate proper operation of the reminder clock as is a calendar indicating the days and times when stored reminder messages are to be recalled from memory and displayed.
Patent JP-2742953-B2 (JP)
IPC: G01N33/543
Filed: 1989-05-10
Granted: 1998-04-22
Abstract: A method for the flow cytometric assay of an analyte using monodisperse particles carrying a specific binding partner, the analyte and binding partner being selected from the group consisting of (a) antigen and specific antibody, (b) hormone and hormone receptor, (c) hapten and antihapten, (d) polynucleotide and polynucleotide binding protein, (e) biotin and avidin or streptavidin, (f) enzyme and enzyme cofactor and (g) lectin and specific carbohydrate, and the method comprising the steps of adding to the aqueous sample a predetermined amount of particles and a predeterminded amount of a labelled ligand having affinity for the analyte or the binding partner and detecting and quantifying the resulting labelled ligand-carrying particles by a flow cytometer, the method using a pair of different particle types which are distinguishable from each other by the flow cytometer and which respectively carry binding partners having the same specificity but different binding affinity for the analyte and independently but simultaneously detecting the two types of labelled ligand-carrying particles by the flow cytometer.
Patent JP-3088015-B2 (JP)
IPC: C07D233/61
Filed: 1992-03-17
Granted: 2000-09-18
Abstract: PCT No. PCT/EP92/00591 Sec. 371 Date Apr. 20, 1994 Sec. 102(e) Date Apr. 20, 1994 PCT Filed Mar. 17, 1992 PCT Pub. No. WO92/17451 PCT Pub. Date Oct. 15, 1992.    <IMAGE>  (I)  Compounds of formula (I) or a biolabile ester thereof, or a pharmaceutically acceptable salt of either, wherein Rl, R2, R3 and R4 are each independently selected from H or C1-C4 alkyl; R5 is (CH2)mSO2R6, (CH2)mNHSO2R6 or (CH2)mNHCOR7; R6 and R7 are C1-C6 alkyl, C1-C3 perfluoroalkyl(CH2)n, C3-C6 cycloalkyl(CH2)n, aryl(CH2)n or heteroaryl(CH2)n; or R6 is NR8R9; R8 is H or C1-C4 alkyl; R9 is C1-C6 alkyl, C3-C6 cycloalkyl(CH2)n, aryl(CH2)n or heteroaryl(CH2)n; or R8 and R9 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring which may optionally incorporate a carbon-carbon double bond or a further hetero atom linkage selected from O, S, NH, N(C1-C4 alkyl) and N(C1-C5 alkanoyl), and which may optionally be substituted with one to three substituents each independently selected from C1-C4 alkyl and C1-C4 alkoxy, and which may optionally be benzo-fused; X is CH2, CHCH3, C(OH)CH3, C=CH2 or O; m is 0 or 1; n is 0, 1, 2 or 3; and Het is 3- or 4-pyridyl or 1-imidazolyl; with the proviso that when Het is 1-imidazolyl then X is CH2 or CHCH3, are combined thromboxane A2 synthetase inhibitors and thromboxane A2/endoperoxide antagonists of utility in the treatment of disease conditions in which thromboxane A2 is a causative agent.
Patent JP-3650110-B2 (JP)
IPC: A61P1/16
Filed: 1994-08-01
Granted: 2005-05-18
Abstract: Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.
Patent JP-3681392-B2 (JP)
IPC: A61M5/36
Filed: 1995-06-28
Granted: 2005-08-10
Abstract: PCT No. PCT/SE95/00797 Sec. 371 Date Mar. 31, 1997 Sec. 102(e) Date Mar. 31, 1997 PCT Filed Jun. 28, 1995 PCT Pub. No. WO96/04944 PCT Pub. Date Feb. 22, 1996Drip chamber heads are disclosed for attachment to drip chambers in which the drip chamber head includes a vertical body, a first connector for connecting the body to a blood supply, and a drip tube disposed within the body including a depending lower portion, the upper portion of the drip tube being in communication with the first connector so that blood may be supplied to the drip chamber through the first connector and the drip tube, thereby providing the blood at an adjustable level within the drip chamber with an air filled region thereabove, a second connector disposed at the upper portion of the body for communicating with the air filled region of the drip chamber, and an air permeable filter disposed at the upper portion of the body between the second connector and the adjustable level of blood within the drip chamber whereby the air pressure within the air filter region of the drip chamber can be sensed through the second connector.
Patent JP-3418401-B2 (JP)
IPC: C12Q1/689
Filed: 1994-08-18
Granted: 2003-06-23
Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.
Patent JP-3164370-B2 (JP)
IPC: C08L27/16
Filed: 1994-09-28
Granted: 2001-05-08
Abstract: PCT No. PCT/EP94/03239 Sec. 371 Date May 26, 1995 Sec. 102(e) Date May 26, 1995 PCT Filed Sep. 28, 1994 PCT Pub. No. WO95/09081 PCT Pub. Date Apr. 6, 1995The present invention relates to polyamide/polyvinylidine fluoride blends and multilayer tubes made therefrom. The blends have spherical morphology and a polyamide matrix with dispersed polyvinylidine fluoride phases; with the polyamide of the polyamide/polyvinylidine fluoride blend having a shear viscosity of 1.5 to 7 times greater than that of the polyvinylidine fluoride of blend.
Patent JP-4026855-B2 (JP)
IPC: E05F15/72
Filed: 1997-04-25
Granted: 2007-12-26
Abstract: A pneumatic cylinder for actuating fume extraction valves in fume and heat extraction plants has a piston (2) that may be actuated from both sides with at least one working surface and that can be made to slide by pressurised air in a cylinder (1) with at least one working chamber (4), as well as an energy accumulator with regulating means. The regulating means can be controlled by control means to open or keep open the fume extraction valves. In order to obtain a compact pneumatic cylinder for a fume and heat extraction plant which is easy to install, a storage chamber in which air or pressurised air is stored as compressible pressure medium is provided as energy accumulator. The storage chamber is in communication with a compression surface (7) of the piston (2), at its side opposite to the working surface (7), so that pressure medium may flow between the storage chamber and the compression surface (7). The controller actuates a venting valve in communication with the working chamber (4) so that pressurised air may flow between the venting valve and the working chamber (4).
Patent JP-3755897-B2 (JP)
IPC: A61K38/44
Filed: 1996-09-25
Granted: 2006-03-15
Abstract: The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumours based on this protein as a marker, and to the possibility of tumour therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells: (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.
Patent JP-3029045-B2 (JP)
IPC: B23K26/00
Filed: 1991-08-14
Granted: 2000-04-04
Abstract: A method and apparatus for providing a body of material (14) with sub-surface marking in the form of an area of increased opacity to electromagnetic radiation. The method includes directing at a surface of the body (14) a high energy density beam (12, 26) to which the material (14) is transparent, and bringing the beam (12,26) to a focus at a location spaced from the surface and within the body (14) so as to cause localized ionization of the material (14). In a prefered embodiment the apparatus includes a laser (10) as a high energy density beam source and provides means (36, 38) to move the focus of the beam (12,26) relative to the body (14) so as to enable the mark to be of a predetermined shape.
Patent JP-4303785-B2 (JP)
IPC: C07F9/30
Filed: 1995-02-24
Granted: 2009-07-29
Abstract: The title compounds are obtained by racemate resolution of D,L-homoalanin-4-yl(methyl)phosphinic acid via precipitation of one of the diastereomeric salts using chiral bases such as quinine or cinchonine. It is possible to increase the yield of desired enantiomer by transformed racemate resolution when the precipitation of the diastereomeric salt takes place with the racemization of the undesired enantiomer in the presence of (hetero)-aromatic aldehydes. The racemization method is also suitable for structurally different optically active amino acids.
Patent JP-2961195-B2 (JP)
IPC: H01J61/82
Filed: 1995-04-04
Granted: 1999-10-12
Abstract: A metal halide lamp includes a discharge vessel with a ceramic wall and a filling which comprises besides mercury and a halogen also Na, Tl and one or several of the elements from the group formed by Sc, Y and lanthanides. The filling also contains Mg to improve lumen maintenance.
Patent JP-4260879-B2 (JP)
IPC: A61P31/04
Filed: 1995-04-20
Granted: 2009-04-30
Abstract: Compositions comprising outer membrane protein "E", and peptides and oligopeptides thereof, of Moraxella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide, or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide, or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines for insertions into attenuated bacteria in constructing a recombinant bacterial vaccine and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding E as primers and/or probes in molecular diagnostic assays for the detection of M. catarrhalis.
Patent JP-3914260-B2 (JP)
IPC: A61B17/11
Filed: 1996-05-16
Granted: 2007-05-16
Abstract: The present invention relates to a balloon trocar (15) to be inserted through a small incision in the body for dissecting, separating or retracting body tissue. Said ballon trocar comprises a balloon housing portion (18) which is connected to a trocar portion (17) at a first end thereof and which accomodates a balloon (16) which is sealingly connected to the proximal end of the balloon housing and to the trocar portion (17) at its second distal end. The balloon extends from said second distal end back through the trocar to the proximal balloon housing portion (18), wherein the balloon trocar (15) is fitted with an inflation port (21) so as to be able to inject an inflation medium into the ballon trocar (15) to inflate the balloon (16) such that the balloon is forced to evert out through the trocar portion (17). <IMAGE>
Patent JP-4050329-B2 (JP)
IPC: A23L27/21
Filed: 1998-05-12
Granted: 2008-02-20
Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
Patent PL-151508-B2 (PL)
Title: Rolling bearing, particularly useful for motor vehicle steering wheel guards.
IPC: F16C19/14
Filed: 1988-11-16
Abstract: The bearing consists of an external ring (1) with an acutely restored arch shaped track (4, 5) and internal rings (2, 3) with respective rectilinear or arched tracks (6, 7). This enables equal value load transfers whether it is transversely or axially. The pad is especially useful in motor vehicle steering wheel guards, but can be used in any application where it is necessary to contemporarily transfer the load of a rotating component either around an axis or in a radial sense.
Patent ES-2444014-B2 (ES)
Title: Ajuste de cobertura en redes E-UTRA.
Inventor: CHOU JOEY
IPC: H04W24/10
Filed: 2013-08-02
Granted: 2015-10-08
Abstract: Ajuste de cobertura en redes E-Utra.#Se describen realizaciones de sistemas y técnicas para ajuste de cobertura en redes de acceso radio terrestre universal (E-UTRAN). En algunas realizaciones, un aparato de gestión de red (NM) puede recibir datos representativos de un primer y un segundo informe de fallo de radioenlace (RLF) que incluyen información relacionada con desconexiones respectivas de un primer y un segundo equipo de usuario (UE) de una E-UTRAN. El aparato de NM puede identificar un hueco en un, área de cobertura de la E-UTRAN basándose al menos en parte en el primer y el segundo informes de RLF, y puede realizar una acción de optimización de cobertura y capacidad (CCO) automatizada para reconfigurar los recursos celulares de la E-UTRAN basándose en el hueco identificado. Pueden describirse y reivindicarse otras realizaciones.
Patent ES-2556253-B2 (ES)
Title: Preparaciones antifúngicas destinadas al tratamiento local de onicomicosis
Inventor: VIANT PASCAL
IPC: A61P31/10
Filed: 2015-07-10
Granted: 2016-09-19
Abstract: Preparaciones antifúngicas destinadas al tratamiento local de onicomicosis.#La invención se refiere a las preparaciones antifúngicas en disolución en gamma-butirolactona, útiles para el tratamiento local de onicomicosis.#El efecto terapéutico puede reforzarse mediante la acción queratolítica del ácido salicílico y que puede hacerse que sean ventajosamente viscosas, gelificadas o filmógenas, con o sin coloración.