baber/WOPTO huggingface dataset:
Patent NZ-560354-A (NZ)
Title: Androgen receptor modulator compounds and methods
Inventor: PEDRAM BIJAN
IPC: A61K31/4745
Filed: 2006-06-12
Abstract: Disclosed is a 3, 6-dihydropyrrolo[3,2-f]quinoline compound of Formula I wherein, R1 and R3 each independently is selected from among hydrogen, alkyl, heteroalkyl, haloalkyl, heteroaryl, aryl or R1 and R3 taken together form a carbocyclic ring, R2 and R4 are each hydrogen or R2 and R4 taken together form a bond, R5 is selected from among hydrogen, alkyl, haloalkyl, heteroalkyl, arylalkyl, and heteroarylalkyl andmR6 is hydrogen or F and pharmaceutically acceptable salts, enol ethers, enol esters, acetals, ketals, orthoesters, hemiacetals, hemiketals, acids, bases, solvates and hydrates thereof. Also disclosed is an in vitro method for identifying a compound that modulates the activity of an androgen receptor comprising said compound, a composition comprising said compound and the use of the compound for the formulation of a medicament for the treatment of a disease that us modulated by an androgen receptor e.g. high blood pressure.
Patent NZ-560563-A (NZ)
Title: Dielectric heating apparatus for heating water
Inventor: YATES RICHARD EDGAR
IPC: F24H1/10
Filed: 2008-11-17
Abstract: A dielectric, instantaneous, water heating apparatus is disclosed. The dielectric, instantaneous, water heating apparatus comprises an inlet (1) and outlet (2), first and second electrically non-conducting spacers (3, 4) which couple to and separate first and second electrode structures (5, 6), first and second electrically non-conducting outer cover plates which couple to each side of the electrode structures (5, 6), and an alternating voltage source (10). A water path (9) is defined between the electrode structures (5, 6) and the cover plates through which water flows from the inlet (1), through the apparatus where it is heated, to the outlet (2). The first and second electrode structures (5, 6) are connected to an alternating voltage source that creates an alternating electric field between the first and second electrode structures (5, 6) that permeates the water in water path (9) which leads to heating of the water as it flows through the apparatus from the inlet (1) to the outlet (2).
Patent NZ-561569-A (NZ)
Title: Novel liposome compositions comprising SuccNomegaPE:NomegaPE:additional lipids and TF-NomegaPE:NomegaPE:additional lipids
Inventor: OKADA KAZUSHI
IPC: A61K9/127
Filed: 2006-03-08
Abstract: Disclosed is a targeted liposome comprising one or more phosphatidylcholines, an N-(omega)·dicarboxylic acid-derivatized phosphatidyl ethanolamine, a targeting factor-modified N-(omega)-dicarboxylic acid-derivatized phosphatidyl ethanolamine comprising a targeting ligand other than an intact antibody linked to a second N-(omega)-dicarboxylic acid-derivatized phosphatidyl ethanolamine, an encapsulated drug, and at least one additional lipid consisting of a cholesterol or a cholesterol derivative. The N-(omega)-dicarboxylic acid-derivatized phosphatidyl ethanolamine is represented by Formula 1 and the second N-(omega)-dicarboxylic acid-derivatized phosphatidyl ethanolamine is represented by Formula 3 wherein the substituents are as defined in the specification.
Patent NZ-565557-A (NZ)
Title: Process for determining usage data for a portable hand-activated apparatus and the device for implementing the process
Inventor: CALVET PIERRICK
IPC: B25C1/14
Filed: 2006-07-01
Abstract: A process for adaptively operating a portable hand-activated apparatus that is indirectly fired by a drive piston, where the apparatus further includes a piston propelling motor 3 and a piston damper 18, and the process includes the steps of determining usage data of the apparatus, adapting the power of the apparatus in real time using the usage data and alerting the operator to under-power or over-power firings.
Patent NZ-566396-A (NZ)
Title: Antisense modulation of insulin-like growth factor binding protein 5 expressions
Inventor: FREIER SUSAN M
Filed: 2002-10-07
Abstract: Disclosed is an antisense oligonucleotide 8 to 50 nucleobases in length targeted to nucleobases 580 through 599 or nucleobases 676 through 728 of a coding region, nucleobases 676 through 728 of a coding region, nucleobases 996 through 1205 or nucleobases 1579 through 1598 of a 3' untranslated region of a nucleic acid molecule (SEQ ID NO: 3) encoding insulin-like growth factor binding protein 5, wherein said oligonucleotide specifically hybridizes with one of said regions and inhibits the expression of insulin-like growth factor binding protein 5 when the antisense molecule has at least a 70% complementary sequence to the said targeted nucleobases.
Patent NZ-569782-A (NZ)
Title: Releasably interlocking container covers with a central engagement lug having a drainage channel
Inventor: COONCE RYAN J
IPC: B65D21/02
Filed: 2007-01-16
Abstract: Disclosed is a cover for a plastic container. The cover includes centre panel, a peripheral first closure portion surrounding the centre panel, and an engagement portion. The engagement portion includes an engagement lug and a drainage channel. The engagement lug of is releasably lockable with an engagement lug of a second cover. The first closure portion of the cover is sealingly engageable with a second closure portion of a base so that when the first closure portion and the second closure portion are sealingly engaged with each other, the cover and the base define a sealed storage area.
Patent NZ-578516-A (NZ)
Title: Film dispenser including a lid which when opened presents film to the user
Inventor: NOTTINGHAM ANTHONY
IPC: B65H37/00
Filed: 2009-07-21
Abstract: A film dispenser is disclosed. The film dispenser includes a housing configured to receive and hold a roll of film. The housing has a dispensing opening through which a section of film can pass and a lid movable between an open position, where the dispensing opening is open, and a closed position, in which the dispensing opening is substantially closed. The lid has a film presentation member that is positioned to contact and hold a portion of the film when the lid is in the closed position and to present the portion of film within the dispensing opening for grasping when the lid is moved to the open position.
Patent NZ-585448-A (NZ)
Title: Polyamide film coated with vinylidene chloride copolymer mixture and method for producing the same
Inventor: KUWATA HIDEKI
IPC: C08J7/052
Filed: 2008-11-28
Abstract: Disclosed is a polyamide film coated with a vinylidene chloride copolymer mixture, wherein: on at least one side of a biaxially stretched polyamide film, a vinylidene chloride copolymer mixture layer in which no thermal crosslinking agent is copolymerized is formed by coating without through an intermediary of a primer layer; the vinylidene chloride copolymer mixture is a mixture comprising two or more vinylidene chloride copolymers; and one of the vinylidene chloride copolymers has a crystal melting point in the range of 170 degrees C to 210 degrees C and is present in an amount of 35 to 45 parts by mass in relation to 100 parts by mass of the vinylidene chloride copolymer mixture.
Patent NZ-588854-A (NZ)
Title: Factor ix-polyethylene conjugates with extended half-lives
Inventor: HENRY WILLIAM
IPC: A61P7/04
Filed: 2009-04-24
Abstract: Disclosed is a Factor IX-polyethylene glycol (FIX-PEG) conjugate, wherein one or more polyethlylene glycol groups are bound to Factor IX through a PEG containing moiety which bridges two cysteine residues which form a disulfide bond in Factor IX. Also disclosed is a Factor IX-polyethylene glycol (FIX-PEG) conjugate, wherein one or more polyethlylene glycol groups are bound to Factor IX through a PEG containing moiety which bridges one or more reduced cysteine disulfide bonds. Further disclosed is the use of the FIX-PEG conjugates a pharmaceutically acceptable diluent, adjuvant or carrier in the manufacture of a pharmaceutical composition for treating hemophilia B.
Patent NZ-591372-A (NZ)
Title: container with compartments for extemporaneously preparing a hot beverage from a soluble powder
Inventor: BRIZIO ADRIANA
IPC: A47J31/30
Filed: 2008-10-24
Abstract: Disclosed is a device (101) for extemporaneously preparing a hot beverage from with the use of a soluble powder. The device comprises a container (10) which is divided into an upper hollow space (12) and a lower hollow space (14) by a baffle (28). The lower hollow space contains a quantity of drinkable liquid (32) and the upper hollow space a quantity of soluble powder (30) able to produce the beverage. An elongated hollow element (16, 26) is provided, which is open at its two ends and which connects the lower and the upper hollow spaces. The container has sealing means for sealing the connection between the upper and the lower hollow spaces through the elongated element. The sealing means can be made ineffective by intervention of the user or once a predetermined pressure inside the liquid or a predetermined temperature of the liquid has been reached.
Patent NZ-592152-A (NZ)
Title: Stable emulsions for producing polymer modified asphalt binders or cements
Inventor: BAUMGARDNER GAYLON
IPC: C08K5/53
Filed: 2009-10-01
Abstract: An asphalt binder comprising a stable emulsion formed from a polyphosphoric-based-acid modified asphalt binder, a reaction product of an amine and a phosphorous-based acid and water, and a method of forming an emulsified asphalt binder material is disclosed, wherein the method comprises the steps of: (i) forming a base asphalt binder material by combining an asphalt binder and polyphosphoric acid; (ii) mixing an amine compound and a phosphorous-based acid in water to form an emulsifier solution including a reaction product of an amine and a phosphorous-based acid; and (iii) mixing the base asphalt binder and the base emulsion to form the emulsified asphalt binder.
Patent NZ-595169-A (NZ)
Title: Electrical heating device
Inventor: RAGG CHRISTOPHER WILLIAM
IPC: F24H1/20
Filed: 2010-02-09
Abstract: 595169 Disclosed is an electrical heating device (10) for heating water. The heating device (10) includes a plurality of heating elements (20, 30) operable to heat water stored within a vessel. The plurality of heating elements (20, 30) are all arranged to be in thermal contact with a single thermostat (40) adapted to cut off the supply of electrical power to said plurality of heating elements (20, 30) when the temperature of the thermostat (40) exceeds a predetermined maximum temperature that indicates overheating of at least one of the heating elements (20, 30). The plurality of heating elements (20, 30) are mounted on a common support plate (50). The thermostat (40) is mounted on the common support plate (50), and at least a portion of each heating element (20, 30) remote from the ends of the heating element (20, 30) is in contact with the support plate (50) adjacent the thermostat (40).
Patent NZ-596236-A (NZ)
Title: Inhibitors of human immunodeficiency virus replication
Inventor: SIMONEAU BRUNO
IPC: C07D413/00
Filed: 2010-05-13
Abstract: 596236 Disclosed herein are compounds of formula (I), wherein the variables are defined in the specification, and their use in the treatment of an HIV infection. Exemplary compounds include: (2S)-tert-butoxy-[2,5-methyl-4-(6-chromanyl)-5-(3-bromophenyl)-pyridin-3-yl]acetic acid; (2S)-tert-butoxy-(2,5-methyl-4-(4-chlorophenyl)-5-(N-2-methoxy-4-chlorobenzamide)-pyridin-3-yl)acetic acid; and (2S)-tert-butoxy-(2,5-methyl-4-(4-chlorophenyl)-5-(3-methyl-imidazo[1,2-a]pyridin-2-yl)-pyridin-3-yl)acetic acid.
Patent NZ-596263-A (NZ)
Title: Water-based personal moisturizers and lubricants for use as vaginal lubricants
Inventor: GUPTA VIBHA
IPC: A61K9/06
Filed: 2011-11-07
Abstract: ABSTRACT - 596263 Disclosed herein is a composition comprising: (a) an aqueous lubricant base comprising a combination of lubricious agents in an aqueous balanced salt solution wherein the combination comprises methylparaben and one or more of: a glycerol, arabinogalactan, PACGH, dextran, polyacrylic acid, carbomer, polyethylene oxide, copolymers of ethylene oxide and propylene oxide, methylcellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, polyethylene glycol, propylene glycol, hydroxypropyl guar, or a plant oil; and (b) a viability-maintaining agent comprising a combination of calcium, sodium, potassium, and magnesium ions; wherein the composition is a lubricant composition formulated for vaginal use which excludes therapeutic drugs, has a pH in the range of 5.0-9.0, an osmolality in the range of 200 to 700 mOsm/kg, and kills less than about 1% of the spermatozoa that are exposed to the composition. This aqueous lubricant composition is suitable as a personal moisturizer and lubricant that relive vaginal dryness and may promote binding of sperm to eggs, and/or facilitate the process of fertilization of an oocyte.
Patent NZ-601602-A (NZ)
Title: Water heating system with flow directable between starage tank, solar heater and instantaneous heater using pump and diverter valve
Inventor: PUSSELL PATRICK
IPC: F24D17/00
Filed: 2009-11-03
Abstract: Disclosed is a hot water system (120) comprising a water storage tank (16), an instantaneous-type water heater (12), a pump (122), a diverter valve (124), at least one solar panel (98) and a controller (42). The storage tank (16) has first (134) and second (150) inlets and first (138) and second (30) outlets. The instantaneous-type water heater (12) has an inlet (18) and an outlet (20) in fluid communication with the first inlet (134) of the tank (16) and is adapted to energise in response to a flow of water through the water heater (12). The pump (122) has an inlet (142), in fluid communication with the first outlet (138) of the tank (16) and with a mains water supply (26), and an outlet (144). The diverter valve (124) has an inlet (126) in fluid communication with the outlet (144) of the pump (122), a first outlet (128) in fluid communication with the inlet (18) of the water heater (12) and a second outlet (130). The at least one solar panel (98) has an inlet (104), in fluid communication with the second outlet (130) of the diverter valve (124), and an outlet (108), in fluid communication the second inlet (150) of the tank (16). The controller (42) is adapted to selectively energise the pump (122) and to control the diverter valve (124) to direct water to the first outlet (128) of the diverter valve (124) for circulating water between the water heater (12) and the tank (16) or to direct water to the second outlet (130) of the diverter valve (124) for circulating water between the at least one solar panel (98) and the tank (16).
Patent NZ-602213-A (NZ)
Title: Lifting unit for lifting a rotor of a wind energy installation
Inventor: LULKER FRANK
IPC: B66C1/12
Filed: 2011-03-23
Abstract: A lifting unit for lifting a rotor of a wind power installation with at least one rotor blade, comprising at least one first sling 100, at least one transverse strut 900, at least one first and second strut or sling portion 300,400 and at least one first and second hinge unit 200,210. The first and second struts or sling portions extend between the first and second hinge units 200,210 and the transverse strut 900. There is also at least one second sling having first and second sling portions 510,520 and a strut. The first ends of the first and second sling portions 510,520 are fixed to the first and second hinge units 300,400.
Patent NZ-607224-A (NZ)
Title: Non-lipidated variants of neisseria meningitidis orf2086 antigens
Inventor: ANDERSON ANNALIESA SYBIL
IPC: C07K14/22
Filed: 2011-09-08
Abstract: Disclosed is a composition comprising an isolated non-pyruvylated non-lipidated ORF2086 polypeptide. The disclosed polypeptides comprising a non-pyruvylated non-lipidated ORF2086 polypeptide has the cys at position 1 deleted, such as SEQ ID NOs: 44, 49 or 50. Further disclosed are nucleic acids encoding said polypeptides and methods of use thereof.
Patent NZ-610851-A (NZ)
Title: Compounds and compositions for the treatment of cancer
Inventor: GAGNON LYNE
IPC: C07C323/62
Filed: 2011-10-26
Abstract: Disclosed herein is the use of compounds of formula IC or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cancer. Also disclosed is the use of these compounds in combination with another known anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
Patent NZ-616198-A (NZ)
Title: Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
Inventor: MILITZER HANS-CHRISTIAN
IPC: C07D487/04
Filed: 2012-03-29
Abstract: Disclosed are 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salts of formula (II) : or a tautomer, solvate or hydrate thereof; methods of preparing said dihydrochloride salt; said dihydrochloride salt for the treatment and/or prophylaxis of a disease; the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer; a pharmaceutical composition comprising said dihydrochloride salt; and a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
Patent NZ-616457-A (NZ)
Title: Fused imidazole derivatives useful as ido inhibitors
Inventor: MAUTINO MARIO
IPC: C07D487/04
Filed: 2012-04-12
Abstract: Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated inimunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. In one embodiment the compound is 1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-I-yl)-2-(3-hydroxyphenyl)ethanone.
Patent NZ-617430-A (NZ)
Title: Taxane and abeo-taxane analogs
Inventor: MCCHESNEY JAMES D
IPC: C07D309/00
Filed: 2012-04-06
Abstract: The disclosure relates to abeo-taxane derivatives of general formula I and II, wherein the unspecified groups are defined in the specification. The disclosure also relates to pharmaceutical compositions comprising these compounds and their use in the treatment of cancer. Example compounds include: 10-alpha abeo-taxane-2-methylpropenyl acetal. 10-alpha abeo-taxane-2,6-dimethyl-1,5-heptadienyl acetal. 10-alpha abeo-taxane benzylidene acetal. The disclosure also relates to taxane derivates.
Patent NZ-618801-A (NZ)
Title: Substituted cinnamamide derivative, preparation method and use thereof
Inventor: MA XIAOHUI
IPC: C07D317/64
Filed: 2012-06-26
Abstract: Disclosed herein are substituted cinnamamide derivatives of formula I where the substituents are as defined herein. Also disclosed is a method for preparing the substituted cinnamamides of the present invention and salt derivatives thereof by using the substituted piperonal derivatives as raw materials via a Wittig reaction and an acid-amine condensation reaction. Further disclosed is the use of the compounds in the manufacture of a medicament for the treatment of mental diseases such as depression. Examples of the compounds of formula I include N-isobutyl-5’-nitro-3’,4’-methylenedioxy cinnamamide and 1-(5-trifluoromethyl-3,4-methylenedioxy benzoyl)-piperidine.
Patent NZ-702345-A (NZ)
Title: Lentiviral vectors containing an mhc class i promoter
Inventor: SARRY EMELINE
IPC: C12N15/86
Filed: 2013-04-30
Abstract: The present invention relates to the insertion of a promoter sequence from an MHC class I gene promoter into a lentiviral vector in order to direct the transcription of a transgene, which preferably encodes an immunogenic polypeptide to be expressed in a mammalian cell host, preferably APC (DCs). The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.
Patent NZ-702712-A (NZ)
Title: Flame-retardant mineral fillers and flame-retardant polymer compositions
Inventor: LORGOUILLOUX MARION
IPC: C09K21/02
Filed: 2013-07-12
Abstract: A powdery mineral filler comprising a calcium compound and a magnesium compound, comprising a semi-hydrated dolomite of general formula aCaCO3.bCa(OH)2.cMg(OH)2.dMg0.eCaO, a, b, c, d and e being molar fractions with (a + b + e)/(c + d) between 0.8 and 1.2, and comprising particle agglomerates, a flame-retardant polymer composition containing same, production methods and use of such mineral fillers.
Patent NZ-708079-A (NZ)
Title: Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as cetp inhibitors
Inventor: LEE JAE KWANG
IPC: C07D413/10
Filed: 2014-01-29
Abstract: The present invention provides biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds of Formula I, stereoisomers thereof, or pharmaceutically acceptable salts. The compounds of the invention show a CETP inhibitory effect that increases HDL-cholesterol levels and reduces LDL-cholesterol levels. Pharmaceutical compositions comprising the compounds are useful for the prevention or treatment of dyslipidemia or dyslipidemia-related diseases.
Patent NZ-708682-A (NZ)
Title: Dosator apparatus for filling a capsule with dry powder
Inventor: PENACHIO ERNEST D
IPC: B65B43/42
Filed: 2013-11-08
Abstract: The present invention provides a dosator for filling a capsule with dry powder when used in an inhalation device comprising: a tube which tapers from the top of the dosator to the bottom of the dosator having an axial passage therein forming an elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen having a mesh size that is smaller than the mass median diameter (D50) of the dry powder disposed between the stationary plunger and the bottom of the dosator; a dosator chamber defined between the mesh screen and the bottom of the dosator of a predetermined height for receiving powder from a powder source and holding the powder until it is expelled into the capsule; at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density; at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator; and wherein the dry powder is characterised by a fine particle fraction of 40% or more and the mass diameter of the particles is between 5 micrometers and 18 micrometers.
Patent NZ-714571-A (NZ)
Title: Systems and methods for multi-user multi-lingual communications
Inventor: LEYDON GABRIEL
IPC: G06F17/28
Filed: 2014-06-03
Abstract: Various embodiments described herein facilitate multi-lingual communications. The systems and methods of some embodiments enable multi-lingual communications through different modes of communication including, for example, Internet-based chat, e-mail, text- based mobile phone communications, postings to online forums, postings to online social media services, and the like. Certain embodiments implement communication systems and methods that translate text between two or more languages. Users of the systems and methods may be incentivized to submit corrections for inaccurate or erroneous translations, and may receive a reward for these submissions. Systems and methods for assessing the accuracy of translations are described.