baber/WOPTO huggingface dataset:
Patent DE-69924864-T2 (DE)
Inventor: MICHELSON GARY KARLIN
IPC: A61F2/28
Filed: 1999-10-29
Granted: 2006-02-23
Abstract: An interbody spinal fusion implant (20) for insertion across a disc space between adjacent vertebral bodies of a human spine has a body (22) two top side and two bottom side junctions, with at least a pair of diagonally opposed junctions having a distance therebetween that does not significantly exceed the implant body height. The implant (20) also includes one or more bone penetrating protrusions (36) extending outwardly from at least the upper and lower walls of the implant. The implant (20) is inserted on its side (28,28') between adjacent vertebral bodies and then rotated 90 degrees into place. The protrusions (36) penetrate the endplates upon rotation, thereby securing the implant (36) within the spine. The implant (20) has at least one passage (38,38') therethrough from the upper wall (30) to the lower wall (30') to promote fusion through the implant (20). Because of the specialized opposed junctions overdistraction between the adjacent vertebral bodies is avoided when the implant (20) is rotated from an initial insertion position to a final deployed position. <IMAGE>
Patent DE-69927507-T2 (DE)
Inventor: LEO PHARMA A S BALLERUP
IPC: A61P17/00
Filed: 1999-07-13
Granted: 2006-03-23
Abstract: A composition is described comprising a vitamin D analog and a retinoid, wherein: (a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and (b) the retinoid is selected from the group consisting of a compound capable of binding a retinoic acid receptor, retinol in a concentration of at least about 0.1% and a compound in a concentration of at least about 0.% capable of being converted in vivo into retinol. Further, methods of treating disorders characterized by abnormal cell-proliferation and/or cell-differentiation are also described.
Patent DE-69930535-T2 (DE)
Inventor: BERREKLOUW ERIC
IPC: A61L33/00
Filed: 1999-10-23
Granted: 2007-01-18
Abstract: The invention relates to an anastomotic device for joining one end of a graft vessel to a target vessel at an opening made in the wall thereof The anastomotic device comprises a tubular body on which an outer flange, which comes into contact with the outside of the wall of the target vessel around the opening, and an inner flange, which comes into contact with the inside of the wall of the target vessel around the opening, are arranged. The inner flange is made up of a number of arms which are able to move from an extended position, located in the extension of the tubular body, under the influence of a pretension into a position extending in the lateral direction with respect to the tubular body, after the pretension has been released, in order to form the inner flange. The invention further relates to an anastomotic device comprising a tubular body with an outer flange and an inner flange thereon, the outer flange and optionally also the inner flange being cylindrically curved with a radius of curvature approximately equal to the radius of curvature of the target vessel.
Patent HU-E028830-T2 (HU)
Title: Human anti-b7rp1 neutralizing antibodies
Inventor: SIU GERALD
IPC: G01N33/68
Filed: 2006-07-18
Abstract: This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
Patent MD-3191511-T2 (MD)
Inventor: BUYSE MARIE-ANGE
IPC: C07K16/24
Filed: 2016-11-14
Abstract: Prezenta invenţie se referă la domeniile variabile unice ale catenei grele de imunoglobulină (denumite în continuare "ISV" sau "ISVD"- immunoglobulin single variable domains) care se leagă la factorul de necroză tumorală alfa conform revendicării anexate. Alte aspecte, variante de realizare, caracteristici, utilizări şi avantaje ale invenţiei vor fi evidente pentru persoana de specialitate pe baza dezvăluirii de faţă.
Patent MD-3233862-T2 (MD)
Inventor: MEVELLEC LAURENCE ANNE
IPC: C07D487/04
Filed: 2015-12-18
Abstract: Prezenta invenţie se referă la derivaţi de imidazopiridazină substituiţi cu Formula (I), în care variabilele au sensul definit în revendicări. Compuşii conform prezentei invenţii sunt utili ca inhibitori pI3K beta. Invenţia se referă, de asemenea, la procedee de preparare a unor astfel de compuşi noi, la compoziţii farmaceutice care cuprind compuşii menţionaţi ca ingredient activ, precum şi la utilizarea compuşilor menţionaţi ca medicament.
Patent TR-200000619-T2 (TR)
Title: Bileşik kapı çerçeveleri
Inventor: ZEN VIC DE
IPC: E06B1/70
Filed: 1998-08-26
Abstract: Kapilara ve benzerlerine takilmaya mahsus bir çerçeve montaji (1) olup, bir çift yan kenarlar (2,3) ve sözü edilen yan kenarlari birlestirmek için bir baslik bölümü (4), ve, talep edildiginde, bir esik, sözü edilen yan kenarlarin her birinin ve baslik bölümününe esigin (5), talep edildiginde, bir termoplastik yapistirici tarafindan bir arada yapistirilmis dolgu malzemesi'nden, artik'tan, ya da geri dönüstürülmüs parçacikli madde malzemesi'nden olan sikistirmali pervaz olmalari, sözü edilen yan kenarlar'in (2,3) her birinin ve baslik bölümü'nün (4), monte edildiklerinde, sözü edilen çerçeve montaji içine takilacak bir kapiyi alacak bir genisligin içeri dogru olarak bakmakta olan bir düzlemsel yüzeyini ve sözü edilen düzlemsel yüzeyin içine dogru olarak çikinti teskil eden, içeri dogru olarak ikinti teskil etmekte olan bir kapi durdurucusunu sunmakta olmalarini ihtiva etmektedir.
Patent TR-200102388-T2 (TR)
Title: Kronik viral enfeksiyonların m. vaccae ile tedavisi.
Inventor: STANFORD JOHN LAWSON
IPC: A61K35/74
Filed: 2000-02-16
Abstract: Bu bulus bir HIV enfeksiyonu hariç olmak üzere, kronik bir viral enfeksiyonun tedavisinde kullanima yönelik bir ilacin imali için bir m. vaccae preparatinin kullanilmasini ortaya koymaktadir. Kronik viral enfeksiyonlar HPV enfeksiyonunu (örnegin servikal displazi ile ilgili  HPV enfeksiyonu gibi), herpes virüsü enfeksiyonunu, sub-akut sklerozlu pan-ansefaliti ve hepatit virüsü enfeksiyonunu içerir.
Patent TR-200200690-T2 (TR)
Title: Bir çukur kapağı elemanı.
Inventor: VINCENT BYRNE DAVID
IPC: E02D17/10
Filed: 2000-09-18
Abstract: Geçici bir çukur kapagi önceden hazirlanmis ve pik metal yapida olan birkaç kapak elemanindan (1) olusur. Benzer kapak elemanlarini düzenek üzerinde birbirine baglamak için olan ara baglanti araçlari bir uçta bir erkek kafa bölümü (35) ve karsi uçta bir disi yarik içerir. Erkek bölüm (35), düzenek üzerindeki bitisik kapak elemanlari arasinda hem yatay hem de dikey düzlemlerde kisitli kontrollü nispi harekete izin verecek sekilde disi yariga geçer. Bu sekilde, kapak elemanlari çukur üzerinde esit bir yüzey saglayarak çukurun kazildigi yer hatlarina kolaylikla uyum saglar ve düzenek üzerinde bir kapak elemaninin yetkisiz olarak çikarilmasini önler.
Patent DE-602004005911-T2 (DE)
Inventor: LEMAIRE VINCENT
IPC: G09F3/02
Filed: 2004-04-01
Granted: 2008-01-17
Abstract: The label (10) consists of a main layer (20) of paper or polymer that has an adhesive coating (30) on the back and a protective layer (40) that is removed before attaching the label to the container. The front of the label has a detachable promotional coupon (50) attached to it by an adhesive (60) that allows the coupon to be removed and used e.g. to claim a partial refund of the cost of the product. The adhesive can be one that dries once the coupon is detached. The label (10) consists of a main layer (20) of paper or polymer that has an adhesive coating (30) on the back and a protective layer (40) that is removed before attaching the label to the container. The front of the label has a detachable promotional coupon (50) attached to it by an adhesive (60) that allows the coupon to be removed and used e.g. to claim a partial refund of the cost of the product. The adhesive can be one that dries once the coupon is detached. The main layer of the label has a small zone (C) on the back that is not coated with adhesive, enabling the whole label to be removed from the container when necessary.
Patent DE-602004006196-T2 (DE)
Inventor: VAIANI GIORGIO SIG
IPC: C12N1/16
Filed: 2004-06-18
Granted: 2008-01-10
Abstract: Pre-packed, long-life preparation including flour, yeast and salt to be completed with just the addition of water, which uses a new yeast formed of a mixture, opportunely treated in subsequent phases, of natural yeast, compressed yeast or dried brewer's yeast and eventual separation liquid obrained from the production of natural yeast where said new yeast may be conveniently dosed and mixed uniformly with the flour and salt and placed in containers of various shapes and sizes, so that said mixture of yeast, flour and salt may be preserved for a long time and may be used directly by the user with just the addition of water.
Patent DE-602004008233-T2 (DE)
Inventor: RICCARDI NICOLA
IPC: B01D47/06
Filed: 2004-03-12
Granted: 2008-05-15
Abstract: In order to provide a phase detector and a method of phase detection which are distinguished by greater sensitivity and simple implementability, at least one differential signal of two input signals (Ua; Ub) may be formed over at least one predefined period by means of a first subtracter (12), at least one maximum value of the at least one differential signal may be detected by means of a first peak detector (16) and at least one minimum value of the at least one differential signal may be detected by means of a second peak detector (18) and at least one further differential signal (UOut) may be formed from the at least one maximum value and the at least one minimum value by means of a second subtracter (14).
Patent DE-60209505-T3 (DE)
Inventor: PEARSON TERENCE
IPC: B29C45/76
Filed: 2002-07-10
Granted: 2012-10-25
Abstract: A process and apparatus for plastics injection moulding comprises injecting a quantity of molten plastics material into a mould cavity (30) and injecting pressurised gas (52) or pressurised liquid into the plastics material in the mould cavity. After holding the pressure of the gas or liquid on the plastics material in the mould cavity for a period of time in order to apply a packing pressure to the plastics material, a portion of the molten plastics material is expelled into one or more secondary cavities (32) or expelled back into the barrel (22) of the injection moulding machine. The step of injecting the plastics material may be effected with or without packing of the plastics material prior to the injection of the pressurised gas or liquid.
Patent DE-60305490-T3 (DE)
Inventor: THOMSON DAVID W
IPC: B65D55/08
Filed: 2003-05-21
Granted: 2011-05-05
Abstract: There is disclosed an improved closure assembly or tamper-evident device(5) adapted to be applied to a mouth and neck portion (10,11) of a container (15) for liquid. There is a need to provide such devices with tamper-indicating features, which, while not acting in any refilling preventive role, give a clear irremovable and/or irreversible indication that a bottle has been opened since being originally filled with genuine contents. Such clear indicators have been somewhat lacking in previous closure designs. Accordingly the invention provides a closure assembly (5) comprising a sleeve (20) adapted to lie substantially concentrically with respect to the mouth (10) and provided with means for fixing the sleeve (20) on the container (15), the closure assembly (5) further comprising a first outer sleeve (25) being a substantially tight fit with the sleeve (20) but rotatable with respect thereto, and a second outer sleeve (30) separate from the first outer sleeve and associated with a container closure member (35), and wherein there are provided means for spacing apart initially adjacent portions of the first and second outer sleeves (25,30) upon reclosure of the assembly (5) after an initial opening of the container (15). The closure assembly also provides a non-refillable device (90).
Patent DE-69228482-T3 (DE)
Inventor: COLLINS BRIAN
IPC: C03C17/22
Filed: 1992-10-12
Granted: 2010-09-16
Abstract: PCT No. PCT/GB92/01858 Sec. 371 Date Apr. 8, 1994 Sec. 102(e) Date Apr. 8, 1994 PCT Filed Oct. 12, 1992 PCT Pub. No. WO93/07099 PCT Pub. Date Apr. 15, 1993Sheet glass (2) is rendered fire resistant such that it will not shatter under a build-up of heat to 900 DEG  C., by providing a thin coating (1) on one or both its surfaces, the coating being stable and adherent to the glass at up to 900 DEG  C., the coating preferably comprising an oxide, nitride, oxynitride or fluoride of a metal or of silicon, or a metal silicide, the sheet having been toughened by tempering before or after coating and having its edges (3) ground and polished before the tempering step to remove all imperfections therefrom.
Patent DE-69319219-T3 (DE)
Inventor: EISENBARTH CHRISTOPH
IPC: G06V30/224
Filed: 1993-08-20
Granted: 2004-05-06
Abstract: Sheets with images are scanned to determine if the images are acceptable. Sheets with unacceptable images are marked with a reject mark. The images may define banknotes, securities, traveler checks, stamps, and so on.
Patent DK-1038863-T3 (DK)
Inventor: LESIEUR DANIEL
IPC: C07C231/12
Filed: 2000-03-24
Granted: 2003-09-22
Abstract: Compounds (I) selected from alkylenedioxybisnaphthalene derivatives and related compounds are new.  Compounds of formula (I) other than diethyl 2-acetylamino-2-(5-(3-(2-acetylamino-3-ethoxy-2-ethoxycarbonyl-3-oxopr opyl)-1H-indol-5-ylmethyl)-1H-indol-3-ylmethyl)malonate and N-(2-(5-(3-(2-acetylaminoethyl)-1H-indol-5-ylmethyl)-1H-indol-3-yl)eth yl)acetamide are new.  A = NR<1>-C(Q)-R<2>, NR<1>-C(Q)-NR<2>R<3> or C(Q)-NR<2>R<3>;  Q = O or S;  R<1> - R<3> = H or R; or  NR<2>R<3> = 1-piperazinyl, piperidino or pyrrolidino;  R = optionally Q'-substituted 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl or (3-8C cycloalkyl)-(1-6C alkyl); 1-6C polyhaloalkyl; or optionally Q-substituted aryl, aryl(1-6C alkyl), aryl(2-6C alkenyl), heteroaryl, heteroaryl-(1-6C alkyl) or heteroaryl-(2-6C alkenyl);  B = NR<1>-C(Q)-R<2>, NR<1>-C(Q)-NR<2>R<3>, C(Q)-NR<2>R<3>, C(Q)-OR<1>, NR<1>-C(Q)-OR<2> or NR<2>R<3>;  G1, G3 = 1-4C alkylene optionally substituted by one or more of OH, COOH, CHO, R, OR, C(O)OR or C(O)R; Cy = a group of formula (i) in which G2 is attached to the benzene ring and G1 or G3 is attached to the other ring, or a group of formula (ii) in which G2 is attached to the D ring and G1 or G3 is attached to the other ring:  X, Y' = S, O, C, CH or CH2;  R<4> = H, halogen, CF3, OH, COOH, CHO, NH2, NHR, NRR', NHC(O)R, C(O)NHR, R, OR, C(O)R or COOR;  R' = R;  Z' = S, O, CH, CH2, NH, NSO2-phenyl or NR; D' = a benzene or pyridine ring;  G2 = an optionally substituted W1(CH2)nW2(CH2)mW3 group containing no adjacent heteroatoms;  W1-W3 = bond, O, S, CH2, CHR, NH or NR;  n, m = 0 - 6;  Q' = one or more of OH, 1-6C alkoxy, 1-6C polyhaloalkyl, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen;  aryl = naphthyl, phenyl or biphenylyl; heteroaryl = a saturated or unsaturated mono- or bicyclic group containing 5-10 C atoms and 1-3 heteroatoms selected from N, S and O; and  Q = OH, COOH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CHO, CN, NO2, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen. Independent claims are also included for the following:  (1) a process for preparing (I); and  (2) compounds of formula (II) other than N-(2-(5-(2-hydroxyethoxy)-1H-indol-3-yl)ethyl)acetamide.  W4 = O, S, NH or NR; and  E' = OH or halogen;  provided that W4-(CH2)n-W2-(CH2)m is not oxyalkylene when Cy is naphthylene and G1-A is (CH2)2-NR<1>CQR<2> or (CH2)2-NR<1>CQNR<2>R<3>.
Patent DK-1142446-T3 (DK)
Inventor: OXFORD J CRAIG
IPC: H04R1/40
Filed: 2000-01-06
Granted: 2003-11-17
Abstract: A speaker system comprises a housing that includes a front wall with a plurality of openings, and first and second exterior sidewalls. A plurality of vertically arranged speakers are each placed into an associated one of the plurality of openings and secured to the housing. A hemispherical concave interior wall is positioned in back of the plurality of speakers and within said first and second sidewalls to disperse and attenuate audio waves within the housing. The housing may also include a tuned, dampening bisector that is mounted to the hemispherical concave interior wall positioned in back of said plurality of speakers and within the first and second sidewalls. The bisector is preferably located at the center of the hemispherical concave interior wall. A rear exterior wall defines a back of the speaker system and the front wall defines a front of the speaker system. The first and second interior sidewalls extend from front to back and preferably taper inward from back to front of the speaker system, wherein the first and second interior sidewalls each mate with the hemispherical concave interior wall. The plurality of speakers preferably include mid-range drivers and tweeters. For example there may be two tweeters associated with every mid-range driver. In one embodiment there are for example twenty-one mid-range driver and forty-two tweeters, wherein two tweeter openings are adjacent to an associated one of the mid-range openings. The speakers are arranged electrically in a series/parallel configuration. For example, several mid-range speakers/drivers are arranged in a series configuration to provide a mid-range subarray, and the number of mid-range drivers placed into each sub-array is selected such that the total Q factor for the sub-array is approximately one.
Patent DK-1280639-T3 (DK)
Inventor: KUKKONEN MATTI
IPC: E04F15/00
Filed: 2001-03-16
Granted: 2007-02-12
Abstract: An object of the invention is an coating assemblage, which comprises a coating (3) that is arranged above a supporting structure (1) and selectively an intermediate layer (2), which is arranged above the supporting structure and under the coating. According to the invention, for receiving a heating means there is formed heat transfer channels (4"') at least to the bottom surface of the coating by means of grooves (48), a form of the cross section profile of which heating means corresponds at least part of the form of the outer circumference defining - the channel.
Patent DK-1297106-T3 (DK)
Inventor: STROH NORBERT
IPC: C12M3/06
Filed: 2001-04-14
Granted: 2005-01-31
Abstract: The present invention relates to a reactor module constructed of hollow fibers and cells as well as to reactors comprising this reactor module.
Patent DK-1343789-T3 (DK)
Inventor: GIANNINI GIUSEPPE
IPC: A61K31/407
Filed: 2001-10-16
Granted: 2005-12-27
Abstract: Compounds of formula useful for treating tumors, particularly mammary carcinoma and colon carcinoma.
Patent DK-1426355-T3 (DK)
Inventor: ISAWA HIDETOSHI
IPC: A61K31/216
Filed: 2002-08-27
Granted: 2009-02-23
Abstract: The present invention provides ethyl (-)-2-Ä4-Ä2-ÄÄ(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylÜaminoÜethylÜ-2,5-dimethylphenoxyÜacetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent  beta 3-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.
Patent DK-1468635-T3 (DK)
Inventor: TIMM EBERHARD
IPC: A47J31/10
Filed: 2003-04-17
Granted: 2005-10-24
Abstract: The appliance for the preparation of hot beverages and soups and the like, in a beaker (15), has a container (1) for the liquid (2) which can be closed by a swing lid (6), fitted with an electrical immersion heater (3). When the liquid is hot, it is emptied into the beaker when a valve (10) is opened at the container. A disk (17) with a projection (18), and passage openings, is inserted into the beaker at a gap from its base, so that the projection opens the valve when the hot liquid container is placed in the beaker. The locking slide (8) for the swing lid acts as the switch (9) for the heater.
Patent DK-1483162-T3 (DK)
Inventor: HAUGEN MATHIAS BAKKE
IPC: B65D41/32
Filed: 2003-02-12
Granted: 2006-10-09
Abstract: A device for repeatedly opening and closure of a container is described. The device comprises a base member ( 1, 20 ) and a top member ( 2, 21 ), where a central bore ( 9, 31 ) is provided in the base member ( 1, 20 ), and where the top member is adapted to be fastened to the basis member ( 1, 20 ) and close the central bore ( 9, 31 ). The top member ( 2, 21 ) is fastened to the base member ( 1, 20 ) by means of retainers ( 11, 27 ) that are forced into interaction with the basic member ( 1, 29 ) by means of a press member ( 19, 24 ).
Patent DK-1527100-T3 (DK)
Inventor: GREENFEDER SCOTT
IPC: C12P21/08
Filed: 2003-03-27
Granted: 2009-09-07
Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Patent DK-1476048-T3 (DK)
Inventor: WALTER HERBERT
IPC: A47F11/10
Filed: 2003-02-24
Granted: 2008-11-17
Abstract: The profiled rail ( 1 ) is designed for a suspension device having carriers ( 6 ) which can be plugged into the profiled rail ( 1 ) and on which articles can be suspended or set down. The profiled rail ( 1 ) is fastened horizontally on a carrying structure ( 9 ) and has a passage ( 10 ) which extends from a front entry point and into which the carriers ( 6 ) can be plugged. Arranged within the profiled rail ( 1 ) is a conductor rail ( 2 ) with current conductors ( 24,27 ) which is supplied with electricity via a power supply ( 3 ), the current conductors being accessible from the passage ( 10 ) for the purpose of tapping electricity for supplying a consuming unit ( 7 ) which can be connected via a feed line ( 46 ). The current conductors ( 24,27 ) can be tapped in an uninterrupted manner over their entire axial extent by means of an adapter ( 4 ) which can be pushed into the passage ( 10 ), can be positioned along the profiled rail ( 1 ) and can be connected and disconnected. The electrification of the profiled rail ( 1 ) gives rise to extended design possibilities for furniture, shop and trade-fair construction, and for outfitting systems, as a result of the integration of electric current.
Patent DK-1505965-T3 (DK)
Inventor: MALININ ALEX
IPC: A61K31/4184
Filed: 2003-05-13
Granted: 2006-11-13
Abstract: The invention relates to a method of inhibiting platelet aggregation comprising administering a therapeutically effective amount of an ARB or its metabolite, especially Valsartan or its metabolite valeryl 4-hydroxy valsartan. Conditions to be treated by inhibition of platelet aggregation include acute myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA (transient ischemic attacks, or acute cerebrovascular syndromes), heart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of any vessel, catheter thrombotic occlusion or reocclusion.