baber/WOPTO huggingface dataset:
Patent DK-1415659-T3 (DK)
Inventor: BROWNING JEFFREY
IPC: C07D401/04
Filed: 2000-01-25
Granted: 2011-10-03
Abstract: Stimulating B-cell growth, immunoglobulin production, or dendritic cell-induced B-cell growth and maturation, or co-stimulating B-cell growth and immunoglobulin production, comprising administering a composition containing the tumor necrosis factor family B cell activating factor (BAFF) or its active fragment, and optionally an anti-Micro antibody, a CD40 ligand or an anti-CD40 ligand, is new. An independent claim is also included for a method of inhibiting B-cell growth, immunoglobulin production, or dendritic cell-induced B-cell growth, or co-inhibiting B-cell growth and immunoglobulin production, comprising administering an anti-BAFF ligand molecule, a recombinant, inoperative BAFF ligand molecule, an antibody specific for BAFF ligand, active fragments of the molecules, or an antibody specific for BAFF ligand receptor, or an epitope of it. ACTIVITY : Immunosuppressive; virucide; antiinflammatory; hypotensive; nephrotropic; cardiant; cytostatic. No biological data is given. MECHANISM OF ACTION : B-cell growth and/or immunoglobulin production stimulators or inhibitors.
Patent DK-1579728-T3 (DK)
Inventor: RASMUSSEN KARSTEN BO
IPC: H04R3/00
Filed: 2003-12-18
Granted: 2008-02-11
Abstract: Hearing aid with a microphone system for providing a directional response by generating a fixed forward pointing directivity pattern and a fixed backward pointing directivity pattern and where the forward and backward directivity pattern signals are mixed at a ratio, which ensures energy minimization of the output signal, and where the fixed directivity patterns are set for optimized directivity when the microphone system is located near or at an object.
Patent DK-1527179-T3 (DK)
Inventor: MORRE MICHEL CHRISTIAN
IPC: A61K38/20
Filed: 2003-08-06
Granted: 2011-01-03
Abstract: The present invention relates, generally, to the fields of immunology and molecular biology. The invention discloses, more particularly, new and improved interleukin-7 drug substances, corresponding specific immunoreactive antibodies, as well as compositions comprising the same, their preparation and uses. The invention also discloses methods to characterize the impurity profile of a r-hlL-7 drug substance used for therapeutic purpose, as well as optimized nucleotide sequences encoding mammalian IL-7, recombinant expression vectors and methods for preparing and purifying said polypeptides. The present invention stems from the unexpected discovery that the long term activity of recombinant IL-7 is mostly expressed by a specific conformer and that other conformers, potential product-related substances, product-related impurities, and process-related impurities, which would normally be included in the specification of the drug substance and/or drug product, although bioactive, should be strictly minimized because they are able to trigger an immune reaction against the desired IL-7 molecule.
Patent DK-1570592-T3 (DK)
Inventor: KARABINIS PETER D
IPC: H04B7/185
Filed: 2003-08-15
Granted: 2008-06-02
Abstract: The capacity of a terrestrial wireless communications system that uses a terrestrial frequency band for communications with wireless terminals is expanded by utilizing a satellite frequency band for terrestrially receiving terrestrial communications from the wireless terminals. Since the wireless terminals are configured to transmit communications to a space-based component such as a satellite via a satellite frequency band, these transmissions also may be picked up (received) terrestrially. Thus, terrestrial base stations can be equipped with satellite frequency band receivers that can receive communications from the wireless terminals over a satellite frequency band. By using the satellite frequency band receiver in a terrestrial base station, additional capacity and/or quality of service may be provided for a terrestrial and/or satellite communications system.
Patent DK-1672987-T3 (DK)
Inventor: STAHL BERND
IPC: A23L33/00
Filed: 2004-06-22
Granted: 2007-10-01
Abstract: The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA),; and at least two distinct oligosaccharides.
Patent DK-1653994-T3 (DK)
Inventor: LUYTEN FRANK
IPC: A61K35/32
Filed: 2004-08-12
Granted: 2010-03-15
Abstract: The present invention disclosed the expression of CXCL6 by cells which are able to form stable cartilage. The invention describes the use of these cells and of CXCL6 to promote cartilage (and underlying bone) formation e.g. in the repair of cartilage or osteochondral defects. The invention further describes the use of chemokines in the modulation of progenitor cell differentiation.
Patent DK-1667522-T3 (DK)
Inventor: GRYAZNOV SERGEI
IPC: C12N15/113
Filed: 2004-09-09
Granted: 2018-03-05
Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
Patent DK-1589276-T3 (DK)
Inventor: JACKSON COLOMER INES
IPC: E04B5/02
Filed: 2005-04-19
Granted: 2007-09-17
Abstract: "Device for the construction of bases"  of the type composed of two elements, concrete slabs (1) and slab union elements formed by two plates, one lower (2) and another upper (3), characterised essentially because the lower plate (2) has at least two perforations both with threads suitable to receive a bolt or stud for their fixing to the upper plate (3), which is formed by two parts united by a dovetail joint, each with a perforation to match those of the lower plate (2).
Patent DK-1808135-T3 (DK)
Inventor: SUYKER WILHELMUS JOSEPH LEONARDUS
IPC: A61B17/08
Filed: 1998-10-22
Granted: 2009-10-05
Abstract: A system for making anastomoses between hollow structures by mechanical means is provided with a device in the shape of an annular or tubular element comprising circumferentially provided means, such as pin-shaped elements, for joining the abutting walls of the hollow structures together. An applicator is intended for moving said annular or tubular element in position and activating the joining means thereof, so as to make the anastomosis.
Patent DK-2171168-T3 (DK)
Inventor: MAISCH CHRISTOF
IPC: E04B2/78
Filed: 2008-07-09
Granted: 2010-11-29
Abstract: The invention relates to a profile element, in particular a construction profile, for example a dry construction profile, a profile for facades or a rendering profile, comprising, in particular a metallic profile body (17, 18) and at least one sealing element (9, 10, 11). Said sealing element is fixed. at least to a longitudinal side of the profile body and is made of a plastic. Openings (13) are embodied in. the longitudinal side of the profile body and the sealing element comprises projections (12) that are embodied as a single piece with the sealing elements for fixing to the profile body (17, 18, 20) on the side of said sealing elements that face the profile body (17, 18, 20), said projections protruding through the openings. The invention also relates to a method for producing said type of profile element.
Patent DK-2498611-T3 (DK)
Inventor: MARTINBOROUGH ESTHER
IPC: A61K31/41
Filed: 2010-11-15
Granted: 2018-04-16
Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
Patent DK-2575884-T3 (DK)
Inventor: OKUN MARTIN M
IPC: C07K16/24
Filed: 2011-06-03
Granted: 2018-09-03
Abstract: The disclosure provides methods and compositions for the treatment of hidradenitis suppurativa. The disclosure describes the methods and uses for treating hidradenitis suppurativa in a subject using a TNFa inhibitor, such as a human TNFa antibody, or an antigen-binding portion thereof. Also described are methods for determining the efficacy of a TNPa inhibitor for treating hidradenitis suppurativa in a subject.
Patent DK-2632885-T3 (DK)
Inventor: ZACHARIE BOULOS
IPC: C07C323/62
Filed: 2011-10-26
Granted: 2018-04-16
Abstract: Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH( OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A snd B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=l-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.
Patent DK-2903699-T3 (DK)
Inventor: KENNEY PETER SINKJÆR
IPC: A62B23/06
Filed: 2013-10-07
Granted: 2018-01-29
Abstract: A nasal filter (1) comprising a frame (2) with a right and a left frame portion (2a, 2b) dimensioned for placement inside a left and right nostril, respective, and optionally connected via a U-shaped bridge (4). Each frame portion (2a, 2b) comprises an anterior support section (6a) towards the front of the nose and a posterior support section (6b) towards the back of the nose, the support sections supporting a filter element (3). Resilient means (8′,9′) connect the anterior support section (6a) with the posterior support section (6b) for flexible change of distance between the anterior support section (6a) and the posterior support section (6b).
Patent DK-0416327-T3 (DK)
Inventor: PHILLIPSON DOUGLAS WAYNE
IPC: A61P31/04
Filed: 1990-08-10
Granted: 1996-01-22
Abstract: Derivatives of antibiotics derived from the microorganism streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta (formula I), are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections. <CHEM> t
Patent DK-0389187-T3 (DK)
Inventor: OCONNOR SEAN PATRICK
IPC: C10M135/02
Filed: 1990-03-15
Granted: 1993-08-02
Abstract: A lubricating oil additive suitable as an extreme pressure/anti-wear additive comprises the product obtainable by reacting at elevated temperature a mixture comprising (i) sulphur, (ii) at least one C10 to C100 unsaturated carboxylic acid, or amide or acid salt thereof and (iii) at least one hydrocarbyl-substituted phenol, the amount of (iii) in the mixture being 15 to 65% w/w based on the combined weight of (i) (ii) and (iii). The reaction mixture can further comprise an olefin and/or, a mercaptan and/or a lubricating oil. The additive is also useful as an anti-oxidant. Additive concentrates and lubricating oil compositions comprise a lubricating oil and the additives of the present invention.
Patent DK-0407262-T3 (DK)
Inventor: PERSELLO JACQUES
IPC: C01B33/193
Filed: 1990-06-26
Granted: 1994-07-04
Abstract: Precipitated silica with controlled porosity and process for obtaining it. The silica of the invention has the following characteristics:     - B.E.T. specific surface of between 20 and 300 m<2>/g,   - C.T.A.B. specific surface of between 10 and 200 m<2>/g,   - oil (DBP) uptake of between 80 and 400 cm<3>/100 g,   - pore volume of 1 to 10 cm<3>/g,   - mean pore diameter varying between 10 nm and 50 nm. n
Patent DK-0449087-T3 (DK)
Inventor: DENICOLA ANTHONY J JR
IPC: C08L51/06
Filed: 1991-03-19
Granted: 1998-04-14
Abstract: A compsn. comprises (a) a resin, consisting of (i) a polyphenylene ether resin, (ii) a styrene resfn, or (iii) mixts. of (i) and (ii); (b) a styrenic grafted propylene polymer; (c) monoalkenyl aromatic hydrocarbon-conjugated diene block copolymers, hydrogenated prods. or mixts.; and (d) a propylene polymer. Amts. of (a), (b), (c) and (d) are 10-65 (pref. 20-60) wt.%, 5-30 (pref. 10-25) wt.%, 1-15 (pref. 4-12) wt.% and 1-70 (pref. 5-55) wt.% respectively. (iii) has 2-98 wt.% of (ii) based on the total amt. of (i) and (ii). The styrenic monomer content of (b) is 5-70 (pref. 10-55) wt.%. The total amt. of (a) + (b) + (c) + (d) is 100%.
Patent DK-0506741-T3 (DK)
Inventor: SPITZ ROBERT A
IPC: C01B17/90
Filed: 1990-11-19
Granted: 1999-06-07
Abstract: The present invention discloses a process for rejuvenation of strip acid employed in the reclamation of expended lead-acid battery acid through extraction and filtration for removing metallic impurities from the battery acid. In the process of removing impurities from battery acid through extraction, the extractant becomes loaded with impurities and loses its effectiveness. Extractant may be regenerated by contacting it with an strip acid. In the present invention, a reduction process is employed to regenerate the strip acid so that it may be used repeatedly. By recycling the extractant and the strip acid in the present invention, the present process further increases the effectiveness of battery acid regeneration-producing a reclaimed battery acid fluid which performs very well in new batteries and substantially reducing by-product waste in the regeneration of the battery acid.
Patent DK-0550580-T3 (DK)
Inventor: RAHIM SAAD GEORGE LANGLEY COUR
IPC: A61K31/505
Filed: 1991-09-25
Granted: 2000-12-04
Abstract: Use of uracilreductase inactivator (I) which is a 5 substd. or 5,6-dihydro-5-substd. uracil deriv. opt. in conjunction with 5-fluorocuracil or their prodrugs in medical therapy is new. The 5-substit. is Br, CN, halo 1-4C alkyl, 2-6C alkenyl, 1-halo 2-6C alkenyl, 2-6C alkynyl or halo 2-6C alkynyl. Also claimed is 5-propynyluracil.
Patent DK-0527285-T3 (DK)
Inventor: GERMANN ALBRECHT JOSEF
IPC: G06T7/00
Filed: 1992-01-23
Granted: 1998-03-30
Abstract: A method is indicated for the evaluation of the quality of printed sheets, which comprises the allocation of a dedicated tolerance band to each of the multiplicity of picture elements, which each consist of a random number of pixels.
Patent DK-0537711-T3 (DK)
Inventor: IMHOF ERICH
IPC: F16L37/092
Filed: 1992-10-14
Granted: 1995-04-10
Abstract: The shear-protected plug-in collar connection is intended for mouldings and for socketed pipes (1) which are produced using the centrifugal casting process and in the case of which the tip end (3) of the one pipe can be pushed into the collar end (2) of the other pipe with radial play. Arranged in the collar end are a sealing ring (8) and a clamping ring (14) which is constructed separately therefrom and has a large number of clamping segments (15) which are arranged with a mutual separation in the circumferential direction and have an outer jacket surface (17) of spherical construction and, on their inner surface (18), in each case one tooth system (19) which, when axial forces occur as a result of the interaction of the spherical jacket surface (17) with an inner surface (18) of the pipe collar (which tapers conically to the end), press radially against the tip end (3). An elastomeric retaining part (20), which can be fixed on the collar end and supports it, is integrally formed on the clamping ring (14). A design which ensures correct retention is achieved even in the case of relatively large nominal widths if the annular-disc-shaped section (23) of the retaining part, which comes to rest on the collar end surface (22), comprises in the region of the inner edge of the collar end surface (22) a transition region (26) which is of reinforced construction and has a higher bending strength, and from which the connecting section (24) which leads to the clamping ring (15) originates, and if the collar end surface (22) has, on the inner-edge side, a recess region which is matched to the cross-section of the transition region (26) which is of reinforced construction. In this case, a steel ring (28) which increases the bending strength and can possibly be inserted through an axial insertion gap (29) is allocated to the transition region (26) of the retaining part, which region is of reinforced construction. 
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Patent DK-0579672-T3 (DK)
Inventor: SCHUELEIN MARTIN
IPC: A23K20/189
Filed: 1992-03-27
Granted: 1999-09-20
Abstract: The xylanase is characterized by several partial amino acid sequences and is immunoreactive with an antibody raised against a purified xylanase derived from Humicola insolens, DSM 1800. This xylanase preparation is practically free of cellulase and is well suited for treatment of paper pulp, as a baking agent and as an additive to fodder.
Patent DK-0563813-T3 (DK)
Inventor: KWON KIM H
IPC: A61K9/00
Filed: 1993-03-26
Granted: 2000-05-22
Abstract: Novel compositions comprising an antiandrogenic compound of the formula <CHEM> wherein R is COR1 wherein R1 is loweralkyl and a vehicle comprising a metabolism modulator and a polar organic solvent, are disclosed.
Patent DK-0612483-T3 (DK)
Inventor: SPERBER GERHARD
IPC: A42B3/06
Filed: 1993-12-08
Granted: 1999-01-11
Abstract: The present invention relates to a helmet, especially a plastic protective helmet for cyclists, and to a method of manufacturing it. To achieve the object of the invention, to provide a plastic helmet which can be produced at a considerably lower manufacturing cost, but with increased resistance to loading, it is proposed to manufacture the helmet in dual-wall (2, 3) construction from blow-moulded plastic. Furthermore, means are to be provided, which bring about a reinforcement of the walls (2, 3) of the helmet (1) relative to one another under compression loading, it being possible for these means to be implemented, preferably, in the form of openings (e.g. 30). <IMAGE>
Patent DK-0571317-T3 (DK)
Inventor: DERLETH HELMUT
IPC: B01J37/03
Filed: 1993-05-18
Granted: 2000-01-03
Abstract: A process is described for preparing fracture-resistant sol-gel particles containing silicon dioxide, which process involves admixing the aqueous solution of an alkali metal silicate, employed in the preparation process, and/or the aqueous solution of an acid with a highly disperse filler.
Patent DK-0609401-T3 (DK)
Inventor: VELZEN DANIEL VAN
IPC: B01D53/77
Filed: 1992-10-15
Granted: 1995-12-27
Abstract: PCT No. PCT/EP92/02381 Sec. 371 Date Apr. 21, 1994 Sec. 102(e) Date Apr. 21, 1994 PCT Filed Oct. 15, 1992 PCT Pub. No. WO93/08121 PCT Pub. Date Apr. 29, 1993.A process and device are disclosed for preparing hydroxylamine from NOx-containing flue gases. Nitrogen removal from the NOx-containing flue gases by absorption in an aqueous solution of FeII-EDTA and by desorption through vapor stripping of the NA from the thus obtained FeII(NO)-EDTA solution, with admixture of hydrogen, leading to the recovery of an NO/H2 gaseous mixture, is combined with hydroxylamine synthesis by catalytic reduction of NO with hydrogen.
Patent DK-0639074-T3 (DK)
Inventor: HAIKALA HEIMO OLAVI
IPC: C07D237/08
Filed: 1993-05-05
Granted: 2000-10-09
Abstract: PCT No. PCT/FI93/00191 Sec. 371 Date Nov. 22, 1994 Sec. 102(e) Date Nov. 22, 1994 PCT Filed May 5, 1993 PCT Pub. No. WO93/21921 PCT Pub. Date Nov. 11, 1993.A method for preventing or treating myocardial ischemia in a mammalian organism is disclosed. The compound [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile or its enantiomer or a pharmaceutically acceptable salt there is administered to a mammalian organism in need of such prevention or treatment. The compound may be administered in its racemic form or in a form which is substantially free of the (+)-enantiomer or substantially free of the (-)-enantiomer.
Patent DK-0720582-T3 (DK)
Inventor: HANSEN ERIK
IPC: B65H29/04
Filed: 1994-08-03
Granted: 1999-06-23
Abstract: PCT No. PCT/DK94/00298 Sec. 371 Date Feb. 5, 1996 Sec. 102(e) Date Feb. 5, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/03989 PCT Pub. Date Feb. 9, 1995A system for conveying flat products, such as folded newspapers. The products are received in imbricated formation on a first conveyor and passed to an intermediate or transfer conveyor, the receiving and of which is at a lower level than the discharge end of the first conveyor. The transfer conveyor accelerates the products to a conveyor which has gripping members that receive the leading edges of the products and which moves at a slower speed than the transfer conveyor. The acceleration of the products on the transfer conveyor assures that the leading edges are received within the gripping members.
Patent DK-0713365-T3 (DK)
Inventor: WASSERMANN LUDWIG
IPC: A23L7/10
Filed: 1994-07-28
Granted: 1998-08-10
Abstract: The invention concerns rye-flours with either less than 7 wt% protein or with more than 12 wt% protein. These flours can be obtained as the result of classification of rye-flour with 7-12 wt% protein.
Patent DK-0666276-T3 (DK)
Inventor: SCHMALSTIEG LUTZ DR
IPC: C08G18/78
Filed: 1995-01-23
Granted: 1999-11-01
Abstract: Polyisocyanate mixts. (I) based on 4,4'-MDI, which are liq. at temps. above 5 degrees C, have (A) a NCO content of 14.5-24 wt.% and (B) an allophanate gp. content of 7.7-14.5 wt.% (calculated as C2HN2O3; mol. wt. = 101). Also claimed is a process for the prodn. of (I) by reacting 4,4'-MDI with 4-16C monohydric alcohols at up to 160 degrees C, with a NCO/OH equiv. ratio of (5:1)-(8.5:1), in the presence of a catalyst for allophanate prodn. (II) which is added at the latest after formation of the intermediate urethane.
Patent DK-0702057-T3 (DK)
Inventor: JAKOB MARTIN DR
IPC: C08L31/04
Filed: 1995-08-24
Granted: 2002-08-26
Abstract: Heterogeneous, solvent- and plasticiser-free polyvinyl esters (I) with a min. film-forming temp. (MFT) of below 10 degrees C, in dispersion or powder form and stabilised with protective colloids, contain (A) a homo- or copolymer with a Tg of above 20 degrees C, derived from (a1) 85-100 wt.% vinyl 1-18 carboxylate ester(s), (a2) 0-5 wt.%  alpha , beta -unsatd. carboxylic acid(s), (a3) 0-5 wt.% mono-unsatd. cpd(s). with amino or amide gp(s). and (a4) 0-5 wt.% polyunsatd. monomer(s); and (B) a copolymer with a Tg of below 20 degrees C, derived from (b1) 45-98 wt.% vinyl ester(s) as for (a1), (b2) 2-50 wt.% 1-4C  alpha -monoolefin(s) and (b3) 0-5 wt.% polyunsatd. monomer(s). Also claimed is a process for the prodn. of (I) by mixing a dispersion of (co)polymer (A) with a dispersion of (B), then opt. spray drying and opt. re-dispersing in water.
Patent DK-0723435-T3 (DK)
Inventor: BAICHWAL ANAND R
IPC: A61K31/135
Filed: 1995-04-06
Granted: 2002-02-11
Abstract: A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release matrix and a pharmaceutical diluent. The formulation provides release of metoprolol for at least about 24 hours. Methods of preparation are also disclosed.
Patent DK-0728744-T3 (DK)
Inventor: RODUIT JEAN-PAUL DR
IPC: C07D213/79
Filed: 1994-05-31
Granted: 2002-07-29
Abstract: Prepn. of carboxylic acids of N-contg. aromatic heterocycles comprises: (a) reaction of an N-contg. aromatic heterocycle with formamide in the presence of a strong acid; and (b) conversion of the resulting carboxamide cpd. into the carboxylic acid by alkaline hydrolysis. The reaction step (a) is carried out in the presence of peroxodisulphuric acid or a peroxodisulphate.