baber/WOPTO huggingface dataset:
Patent CZ-22296-A3 (CZ)
Title: Compression spring for disk brakes
Inventor: GERHARDT WINFRIED
IPC: F16D65/097
Filed: 1994-07-08
Abstract: In disk brakes with two brake linings (3, 4) arranged in the shaft of a calliper (1) and which are secured by two holding pins (5, 6) which extend across the shaft, a substantially cross-shaped holding-down spring (13) is provided for preventing the brake linings (3, 4) from clattering. The holding-down spring (13) has a clamping hoop (14) arranged in the circumferential direction of the brake disk (2) that engages the holding pins (5, 6) from behind and a holding-down hoop (15) arranged transversely to the clamping hoop (14) that lies on the the brake linings (3, 4). The ends (16, 17) of the clamping hoop (14) are provided with recesses (18, 19) into which a mounting tool (20) may be inserted. The mounting tool (20) is radially set on the clamping hoop (14) in a simple manner and is pushed further in the same direction (22) until the clamping hoop (14) is elastically expanded. The holding pins (5, 6) may then be inserted without problems without contacting the holding-down spring (13). Once the holding pins (5, 6) are inserted, the mounting tool (20) is removed, so that the ends (16, 17) of the clamping hoop (14) lie one again on the holding pins (5, 6). The mounting operation is thus ended.
Patent CZ-39093-A3 (CZ)
Title: Oligosaccharide and pharmaceutical preparation in which it is comprised
Inventor: SAU-CHI BETTY YAN PH D
IPC: A61K47/06
Filed: 1993-03-10
Abstract: The invention relates to oligosaccharides with the sequence GalNAc beta (1-4) (Fuc alpha (1-3) GlcNAc. They are produced by incubating Human Kidney 293 cells and isolating the novel oligosaccharides from the peptide produced. oligosaccharides can be used to act as high affinity ligands of certain cell adhesion receptors, and may be used to prevent or reduce cell adhesion and inflammation.
Patent CZ-70194-A3 (CZ)
Title: Apparatus for treating foodstuff by air
Inventor: ROTHSTEIN SVEN-OLLE
IPC: F25D13/06
Filed: 1992-10-02
Abstract: An air treatment plant for foodstuffs comprises a housing, an elongate trough provided therein for receiving the foodstuff to be treated, a heat exchanger and a fan assembly for producing an air flow circulating through the heat exchanger, up through the trough and back to the heat exchanger. The housing comprises a plurality of substantially identical modular units (11) extending transversely of the longitudinal direction of the trough and having self-supporting bottom and sidewall panels (14-16; 17, 18), each having a layer of insulating material and, provided on the inside thereof, a layer of stainless steel or similar material. Each modular unit comprises two submodules (12, 13), each having a bottom panel (15, 16) forming part of the bottom of the housing (1), and a sidewall panel (17, 18) forming part of a respective one of the sidewalls of the housing.
Patent CZ-92897-A3 (CZ)
Title: Process for producing rough forging of a connecting rod
Inventor: MORGEN PAUL
IPC: B21K5/18
Filed: 1997-03-26
Abstract: Manufacturing a forged rod of the type incorporating a head, a body and a foot comprises: (a) the fabrication of a forged blank rod (33) free from lateral burrs and incorporating, on its head and foot, at least one reaming scarf; and (b) the continuous calibration of the forged blank rod (33) by squashing the forged blank rod (33) between two inserts (57, 58) inside a die (55) to produce the final forged rod. Also claimed is a forged and trimmed rod fabricated by the above method.
Patent CZ-98598-A3 (CZ)
Title: Molecule of antibody against fas and process for preparing thereof
Inventor: SERIZAWA NOBUFUSA
IPC: C07K14/705
Filed: 1998-04-01
Abstract: Anti-human Fas antibodies which are cross-reactive with mouse and human Fas are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system.
Patent SK-12000-A3 (SK)
Title: Device for cutting the food products equipped with a mechanism preventing its accidental switching
Inventor: BIADUN ANDRZEJ
IPC: B26D7/24
Filed: 2000-01-03
Abstract: The arrangement has a safety arrangement against inadvertent switch-on, whereby the on button (2) can be locked in the off position and released from the lock by a maneuvering knob (4) that is accessible on the on button.
Patent SK-15995-A3 (SK)
Title: Detergent mixtures
Inventor: HELLIWELL JOHN F
IPC: A61Q5/02
Filed: 1993-08-03
Abstract: Shower gel compositions in the form of a liquid or gel comprising 5-50 % wt of a detergent comprising 30-100 % wt (on total detergent) of a fatty acyl isethionate and 0-70 % wt (on total detergent) of other detergent, 0.01-5 % on product of cationic polymer and 0.5-15 % wt by weight of silicone. The compositions show enhanced silicone deposition as compared with composition employing other surfactants.
Patent SK-24194-A3 (SK)
Title: Method of preparation of aqueous solution of nicotinealdehyde
Inventor: SIEGRIST URS
IPC: C07D401/04
Filed: 1994-02-28
Abstract: A process for the preparation of an aqueous medium of nicotinaldehyde by the catalytic reduction of 3-cyanopyridine under hydrogen in the presence of Raney-nickel.
Patent SK-59797-A3 (SK)
Title: A polynucleotide, a vaccine and their use
Inventor: LIU MARGARET A
IPC: A61K48/00
Filed: 1995-11-13
Abstract: Genes encoding Mycobacterium tuberculosis (M.tb, proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were immunised by injection of these DNA constructs, termed polynucleotide vaccines or PNV, into their muscles. Immune antisera was produced against M.tb antigens. Specific T-cell responses were detected in spleen cells of vaccinated mice and the profile of cytokine secretion in response to antigen (85) was indicative of a Th1 type of helper T-cell response (i.e., high IL-2 and IFN-'gamma'). Protective efficacy of an M.tb DNA vaccine was demonstrated in mice after challenge with M.bovis BCG, as measured by a reduction in mycobacterial multiplication in the spleens and lungs of M.tb DNA-vaccinated mice compared to control DNA-vaccinated mice or primary infection in naive mice.
Patent SK-69094-A3 (SK)
Title: Optical isomers of leukotriene antagonists and method of their separation
Inventor: MILLS ROBERT J
IPC: C07D407/10
Filed: 1992-12-11
Abstract: This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.
Patent SK-77496-A3 (SK)
Title: Bottle carrier
Inventor: BAKX MARTINUS
IPC: B65D71/00
Filed: 1994-12-14
Abstract: A top gripping carrier (11) packaging necked articles such as bottles (B) comprises top (18, 28), side (20, 26) and bottom (22, 24) walls, neck receiving apertures (38) and article retaining means (60) disposed intermediate the bottom and top wall adapted to retain the top of the associated article (B) within the carrier obscured from view from above and from the sides of the carton.
Patent SK-81999-A3 (SK)
Title: Intranasal formulations for treating sexual disorders
Inventor: BILLOTTE ANNE
IPC: C07D487/04
Filed: 1999-06-17
Abstract: Intranasal formulations of sildenafil mesylate for the treatment of male erectile dysfunction or female sexual disorders.
Patent AT-515381-A3 (AT)
Title: Unterdecke, welche ein Trageprofil und daran eingehängte Paneele aufweist
Inventor: PEER ROBERT
IPC: E04B9/26
Filed: 2015-01-15
Abstract: Die Erfindung betrifft eine Unterdecke, welche parallel und in einem Abstand zueinander angeordnete Trageprofile (1, 30) aufweist, welche eine nach unten hin offene Einhängenut (4, 32) aufweisen in welche Paneele (2) mit einem hakenförmig gekrümmten Seitenwandbereich von unten her eingehängt sind. Ein Trageprofil (1, 30) weist beidseits seitlich neben der Einhängenut (4, 32) jeweils eine Haltenut (18, 33) auf, in welcher ein Element (28, 19), welches der Befestigung des Trageprofils (1, 30) dient, verankert ist. Ein Abklapphaken (3, 13, 31), welcher schwenkbar mit dem am Paneel (2) verbunden ist und mit einer die Einhängenut (4, 32) seitlich begrenzenden Wand verhakbar ist, ist so geformt, dass die Verhakung auch während des Schwenkens des Abklapphakens von der Vertikalen in die Horizontale immer aufrecht bleibt.
Patent CZ-256392-A3 (CZ)
Title: Control device for outlet valve of a flushing cistern
Inventor: RIEHM THOMAS
IPC: E03D1/34
Filed: 1992-08-20
Abstract: The actuating device has a tilt button (4) which is mounted on a holder (3) and is connected to the valve body (8) of a discharge valve, via a two-armed lever (6), such that, when the tilt button (4) is pivoted, the valve body (8) can be lifted in order to open the discharge valve. The lever (6) is mounted in a frame (7), an engagement part of the lever (6) rolling, without sliding, on a rolling-contact curve (7b) of the frame (7) when the tilt button (4) is actuated. In this arrangement, the turning point of the lever (6) is displaced such that the comparatively large initial force reduction decreases continuously and the path reduction increases. As a result, the discharge valve can be opened by a small amount of force, with a relatively small button displacement. <IMAGE>
Patent CZ-310691-A3 (CZ)
Inventor: SVORCIK VACLAV ING CSC
IPC: C09J5/02
Filed: 1991-10-14
Abstract: Způsob zvýšení smáčivosti a lepivosti polyolefinů spočívá
v tom, že se exponují ve vodném roztoku chloridů sodíku,
draslíku, lithia nebo jejich směsí, s výhodou o koncentraci
1,5 až 10 mol.l"1 pří teplotě varu.
Patent CZ-379891-A3 (CZ)
Title: Electrolytic source of pressurized hydrogen
Inventor: DOUSEK FRANTISEK RNDR CSC
IPC: C25B1/04
Filed: 1991-12-13
Abstract: The compressed hydrogen electrolytic source is formed by electrolytic cells (1) electrically connected in series and an electrolyte reservoir (4) connected with individual cells (1) by the inlet distribution and output collection channel (3, 2). The electrolyte reservoir (4), in relation to the system of electrolytic cells (1), is positioned so as to achieve the given minimum height of the oxygen column in the mixture with electrolyte in the oxygen inlet pipe, formed by the outlet interconnecting and collection channel (6,2), whose inner diameter does not exceed 6 mm. In this way the conditions for continual circulation of electrolyte (5) in the system are created.<IMAGE>
Patent CZ-494588-A3 (CZ)
Title: tilting gate of lock chambers upper cutwater with direct filling
Inventor: MALIK OTO ING
IPC: E02B7/20
Filed: 1988-07-08
Abstract: Flap (1) with leveled or hydraulic rounded fence wall (6) reinforced by beams (7) and bonded to carrier pipe (3) is through pull-out pins (19) is placed in shaft (18) respectively on the opposite side in the bearing anchored in pier.  She is operated by double-acting hydraulic motor (10) located in the side pier by shaft (18) witch is fixed with level hydraulic motor (13) and operating level (16). Pushed in piston bar (28) of hydraulic motor (10) responds to raised flap opposite to the course of water, when is filling opening, limited by filling console (4) and sealing sill (23) is maximal. By partially push-out piston bar (15) is the flap is inclined to the course of water, while filling console (4) is still sealing on the sill (23) and by completely push-out piston bar (27) is the flap completely folded down in the course of water.
Patent CZ-647390-A3 (CZ)
Inventor: BEBR KAMIL ING
IPC: F02M39/02
Filed: 1990-12-20
Abstract: Ovládací zařízení, zvláště pro výtlačné jednotky (9) spalovacího
motoru, se vstřikováním paliva do spalovacího
prostoru prostřednictvím vstřikovací trysky (14) a s výtlačnou
jednotkou (9) uspořádanou vzlášť pro jednotlivé válce
a s vačkovým hřídelem (1) společně ovládajícím výtlačné
jednotky (9) a ventilový rozvod, má výtlačnou jednotku (9)
uloženou ve vývrtu (6) hlavy (8) válce a její spodní část má
opatřenou ovládací tyčkou (5), která je spodnínm koncem
opřena v zahloubení vahadla (3), spočívajícím svojí kladkou
(24) na vačce vačkového hřídele (1) ventilového rozvodu,
uspořádaného v bloku (17) válců.
Patent CZ-103494-A3 (CZ)
Title: Process for preparing 4-methyl-5-(2-chloroalkyl)thiazole derivative and 4-thiocyanato-5-chloro-2-alkanone employed as intermediate during said process
Inventor: PALOSI ENDRE
IPC: A61K31/00
Filed: 1992-10-30
Abstract: The invention relates to 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazoles of the general formula I, <CHEM>  wherein R is a straight-chain 2-chloro-C2-5-alkyl group  and a process for their preparation, which is characterized by     (A1) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the general formula IV <CHEM> in an organic solvent with gaseous hydrogen chloride to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the general formula II   <CHEM>  or   (A2) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C2-5-alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III <CHEM> and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above formula II,  and   (B) hydrogenating the compound of the general formula II to obtain the 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above general formula I.   The invention further relates to intermediates for the above process, and pharmaceutical compositions comprising the compounds of formula I.
Patent CZ-124298-A3 (CZ)
Title: Process for preparing multilayer of medicaments in solid form for oral or rectal administration
Inventor: BREITENBACH JORG DR
IPC: A61K31/192
Filed: 1996-10-23
Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
Patent CZ-174096-A3 (CZ)
Title: Process for preparing aromatic amines by hydrogenation in gaseous phase and a catalyst for making the same
Inventor: LANGER REINHARD DR
IPC: C07C209/36
Filed: 1996-06-13
Abstract: Prodn. of an aromatic amine of formula Ar-NH2 (I) comprises gas phase hydrogenation of a nitroaromatic of formula ArNO2 (II) with H2 over a stationary catalyst (C). The H2 supply to the catalyst is 30-6000 equiv. per NO2 gp. equiv. Ar = phenyl (substd. by R1 and R2); R1 = H, Me or Et; R2 = H, Me, Et, NH2. (C) comprises Pd and Pb on a graphite or graphitised coke support with a BET surface area of 0.2-10 m<2>/g, contg. 0.001-7 wt.% Pd w.r.t. total catalyst and 0.1-50 wt.% Pb w.r.t. Pd. Also claimed is (C), esp. for the hydrogenation of nitro-aromatics.
Patent CZ-196395-A3 (CZ)
Title: Process for preparing ethylene and alpha-olefin interpolymers
Inventor: KOLTHAMMER BRIAN W
IPC: C08L23/08
Filed: 1994-01-28
Abstract: Processes for polymerizing ethylene/a-olefin interpolymer compositions are disclosed. The interpolymer compositions have a controlled composition and a controlled molecular weight distribution. The processes utilize a highly-efficient homogeneous catalyst composition in at least one reactor to produce a first interpolymer having a narrow composition distribution and a narrow molecular weight distribution, and a highly-efficient heterogeneous Ziegler catalyst in at least one other reactor. The reactors can be operated sequentially or separately, depending upon the desired product. The novel compositions have good optical properties (e.g., clarity and haze) and good physical properties (e.g., modulus, yield strength, toughness and tear). Useful products which can be formed from these compositions include film, molded articles and fiber.
Patent CZ-200640-A3 (CZ)
Inventor: MARYSKA MARTIN
IPC: A61K33/06
Filed: 2006-01-19
Abstract: Prípravek pro prevenci a lécbu iniciálního zubního kazu, který je tvoren fosfátovápenatým gelem s hmotnostním pomerem Ca/P v rozmezí 1,2 az 2,2 a s vazebnou energií elektronu 2p fosforu 131 eV az 136eV a prípadne alespon jednou dentální pomocnou látkou. Prípravek výhodne dále obsahuje vodný roztokmethylcelulózy nebo/a glukonátu chlorhexidinu.
Patent CZ-268798-A3 (CZ)
Title: Railway vehicle with body casing and process for producing thereof
Inventor: BERTLING LUTZ
IPC: B61D17/00
Filed: 1997-02-08
Abstract: In a rail vehicle with a modular-construction body (2), individual major modules (5-8) like floor, roof and side-wall modules and possibly end-wall modules or a driving cab are first made, assembled and fitted out, operationally tested and then joined together in the region of adjacent side edges (19) by a cold or low-heat method.
Patent CZ-375896-A3 (CZ)
Title: Metal-cutting center
Inventor: GRUNER MAGNUS
IPC: B23Q7/14
Filed: 1995-06-20
Abstract: The proposal is for a machining centre for machining workpieces (26). It has at least one working unit (22) with a rotary tool (24) for machining a workpiece (26) arranged in a machining section (28). The workpiece (26) is firmly clamped on a workpiece holder (15) fitted with a clamping device (25) for that purpose. The workpiece holder (15) can be taken to a workpiece changing station (35) where the workpiece can be changed. During this process the workpieces (26) are taken up and laid down from above by the clamping device (25). During machining the workpiece (26) is secured in suspension from the workpiece holder (15). The machining centre ensures high productivity with the smallest operating effort.
Patent CZ-488188-A3 (CZ)
Inventor: BOFFELLI PIER CARLO
IPC: B23B29/32
Filed: 1988-07-05
Abstract: Nástrojováhlava májednak hnací motor (12,54), připojený k
ozubené diferenciální převodovéjednotce, tvořené třemi
členy, přičemž první člen (15,47,57) ozubené diferenciální
převodovéjednotkyje připojen k hnacímu motoru (12,54),
druhý člen (18,64) ozubené diferenciální převodovéjednotky
je připojen k rotačnímu členu (4,51) a třetí člen (20,66)
ozubené diferenciální převodovéjednotkyje připojen před
vačkové převodové prostředky (21,23,71,72) k neotočnému
axiálně pohyblivému členu (7, 73), jednak obsahuje blokovací
prostředky (29,42, 80) rotačního členu (4,51), blokovací
prostředky (34,35,40,41,76,77) projeden z členů ozubené
diferenciální převodovéjednotky a výstupek (97,116) spojený
s neotočným axiálně pohyblivýmčlenem(7,73).
Patent ES-183432-A3 (ES)
Title: Un separador magnético.
IPC: B03C1/033
Filed: 1946-02-04
Abstract: Mejora en la fabricación de artículos abrasivos tales como papel de lija, correas abrasivas, discos abrasivos y lo semejante, que comprenden granos abrasivos pegados a un material de respaldo flexible por una composición adhesiva o pegados con una composición adhesiva y cubiertos con una capa de encolado de una composición adhesiva, según la cual dicha composición adhesiva comprende esencialmente un adhesivo coloide soluble en agua y una cantidad menor pero considerable de un material orgánico insoluble en agua finamente dividido dispersado, basada sobre el peso en seco de dicha composición adhesiva, constituyendo dicho adhesivo coloide la fase continua, y dicho material orgánico la fase dispersa, teniendo dicho material orgánico un punto de fusión suficientemente elevado de modo que normalmente sea sólido a la temperatura ambiente.
Patent ES-193446-A3 (ES)
Title: PUN ROCEDIMIENTO PARA LA FABRICACIoN DE ENVOLTURAS ARTIFICIALES PARA EMBUTIDOS, ESPECIALMENTE DE TRIPAS DE CALIBRE ESTRECHO, A PARTIR DE UNA MASA FIBROSA INCHABLE DE ORIGEN ANIMAL
Filed: 1950-06-15
Abstract: Procedimiento para la fabricación de envolturas artificiales par embutidos, especialmente de tripas de calibre estrecho a partir de una masa fibrosa hinchable de origen animal mediante extrusión de la masa desde una tobera anular y desecación del tubo formado, caracterizado porque el tubo recien formado, en forma de una cinta plegada plana, se deposita sobre una base sólida lisa, por ejemplo planchas planas, tubos rodillos, tambores, cintas sinfín, se seca en este estado, después de la desecación se retira de al base y de manera conocida en sí, se endurece, se lava y se trata ulteriormente.
Patent ES-199696-A3 (ES)
Title: Perfeccionamientos en los sistemas de textura con telares especiales
Filed: 1951-09-11
Abstract: Perfeccionamientos en los sistemas de textura con telares especiales que consisten esencialmente en disponer en los órganos suministradores de los hilos fibras textiles de distintas clases y condiciones y en utilizar para la confección de los soportes o alma de los productos que en cada caso se podrán obtener determinados efectos relacionados con la resistencia mecánica o con otras características condiciones físicas como capilaridad especial incombustibilidad u otras que quieran obtenerse con los productos que se fabrican.
Patent ES-8506738-A3 (ES)
Title: Heterocyclic thiophosphoric -onic acid esters
IPC: C07F9/165
Filed: 1984-04-02
Abstract: Prepn. of heterocyclic thiophosphoric and thiophosphonic acid esters R1 = C1-4 alkyl-, phenyl-; lower alkoxy- which may be subst. by halor lower alkoxy- R2 = C1-4 alkyl which may be subst. by hal- or lower alkoxy X = O or S Het= 1,2,3-benzotriazin-4(3H)-on-(3)-yl- or a heterocyclic 5-membered ring which may contain 1 or 2 N-atoms, may be subst. or condensed, have another heteroatom in the ring, a double bond, or a -CO- or -CS- gp. next to the -NH- e.g. benzoxazolones and -thiones, benzthiazolones and -thiones, 1,3,4-oxadiazolones and thiones, 1,3,4-thiodiazalones and thiones, or a 5-membered NH-ring which may be subst. or condensed, may contain two -CO- gps. adjacent to the N, or -CO and/or SO2- and a double bond e.g. phthalimide, 1,2-benzisothiazol 1-3(3H)-on-1,1-dioxide. - Insecticides. O,O-dimethyl-s-(phthalimidomethyl)-dithiophosphate.
Patent SK-118199-A3 (SK)
Inventor: NEMCEK MILAN
IPC: E06B3/04
Filed: 1999-08-27
Abstract: Otvorová výplň s úpravou zabezpečujúcou regulované
vetranie a súčasne tlmenie zvuku pozostáva z rámu (1)
a krídla (2) otvorovej výplne, má na interiérovej strane
na profile krídla upevnenú vetracia jednotku (3). Spojenie
vetracej jednotky s exteriérom je uskutočnené cez
potrubie (8) umiestnené v medzere medzi stenou a profilom
rámu (1) alebo cez profily (1) a (2). Vetranie prebieha
pri zatvorenej polohe krídla. Množstvo pretečeného
vzduchu sa reguluje nastavením škrtiacej klapky a
spúšťaním ventilátora (6). Medzi dve vetracie jednotky
môže byť vložený výmenník, ktorý umožňuje recykláciu
tepla.
Patent SK-125494-A3 (SK)
Title: Ornament
Inventor: NAKAMA HIROSHI
IPC: A44C27/00
Filed: 1994-10-13
Abstract: An ornament of the present invention is composed of a light transmission material having a plurality of facets (21), and a plurality of fine grooves (23) are formed on these facets, thereby to increase brilliancy, dispersion and scintillation effects of rays of light so as to heighten the ornamental property. <IMAGE>
Patent SK-145397-A3 (SK)
Title: Genetic sequences and proteins related to alzheimer's disease, and uses therefor
Inventor: RAE PATRICIA A
IPC: C12N15/12
Filed: 1996-04-29
Abstract: The present invention describes the identification, isolation, sequencing and characterization of two human presenilin genes, PS-1 and PS-2, mutations which lead to Familial Alzheimer's Disease. Also identified are presenilin gene homologues in mice,  C. elegans  and  D. melanogaster.  Nucleic acids and proteins comprising or derived from the presenilins are useful in screening and diagnosing Alzheimer's Disease, in identifying and developing therapeutics for treatment of Alzheimer's Disease, and in producing cell lines and transgenic animals useful as models of Alzheimer's Disease.