baber/WOPTO huggingface dataset:
Patent WO-2018226685-A3 (WO)
Title: Methods for sensitizing cancer cells to t cell-mediated killing by modulating molecular pathways
Inventor: PAN DENG
IPC: A61P35/00
Filed: 2018-06-05
Abstract: The present invention is based, in part, on the identification of novel biomarkers, and methods of modulate thereof, for sensitizing cancer cells to T cell-mediated killing. Provided is a method of sensitizing cancer cells in a subject afflicted with a cancer to cytotoxic T cell-mediated killing comprising administering to the subject a therapeutically effective amount of an agent that modulates the copy number, amount, and/or activity of at least one biomarker. Further provided is a method of sensitizing cancer cells to cytotoxic T cell-mediated killing comprising contacting the cancer cells with 1 ) an agent that modulates the copy number, amount, and/or activity of at least one biomarker in the cancer cells and 2) cytotoxic T cells, thereby sensitizing the cancer cells to cytotoxic T cell-mediated killing, is provided. The present invention also encompasses kits for detecting and/or modulating biomarkers described herein.
Patent WO-2019023558-A3 (WO)
Title: Fat-based filling comprising micronized bran
Inventor: FOUCAULT MICHAEL
IPC: A23D7/005
Filed: 2018-07-27
Abstract: The present invention relates to a fat-based filling comprising fat, sugar and micronized cereal bran, preferably micronized wheat bran. In particular the invention relates to a sugar reduced fat-based filling comprising fat, sugar and micronized cereal bran, preferably micronized wheat bran. The present invention further relates to a food composition comprising the fat-based filling of the present invention. The present invention further relates to the use of micronized cereal bran, in particular micronized wheat bran, to reduce sugar content of a fat-based filling.
Patent WO-2020131875-A3 (WO)
Title: Microcapsules préparées à partir de protéines
Inventor: SASAKI TAKASHI
IPC: C11D17/08
Filed: 2019-12-17
Abstract: L'invention concerne des compositions de microcapsules comportant une microcapsule dispersée dans une phase aqueuse. La microcapsule comprend un noyau de microcapsule et une paroi de microcapsule. Le noyau de microcapsule contient une substance active. La paroi de microcapsule encapsule le noyau de microcapsule et est formée d'un réseau polymère ayant une fraction protéique, une fraction électrophile multifonctionnelle et une troisième fraction dérivée d'un agent chaotropique, d'un nucléophile multifonctionnel, ou d'une combinaison de ceux-ci. L'invention concerne également un procédé de préparation et des produits de consommation contenant la composition de microcapsule.
Patent WO-2020185399-A3 (WO)
Inventor: PANESCU DORIN
IPC: A61B18/14
Filed: 2020-02-26
Abstract: A system for treatment of a target region of lung tissue including: a flow regulator configured to be interposed between a conductive fluid source and a conductive fluid outlet positionable at or in proximity of the target region of lung tissue, the flow regulator being further configured for controlling a flow rate or a bolus quantity of conductive fluid coming from the fluid source and delivered to the conductive fluid outlet; and a controller communicatively connectable with said flow regulator and with at least one sensor, with the at least one sensor being configured for detecting values taken by at least one control parameter representative of a physical property, wherein the physical property is one of temperature (T), pressure (p), electric impedance (Z), or electric conductivity (C) of material present at or in proximity of the target region of lung tissue. A solution which may be delivered using the system is also disclosed.
Patent WO-2020180908-A3 (WO)
Inventor: CHISHOLM BRIAN
IPC: B29C64/264
Filed: 2020-03-04
Abstract: This disclosure describes container(s) having an ultraviolet (UV)-cured matrix and methods to create the same. For example, a glass container (10) according to this disclosure has a bottom (16) and a body (14) extending in a direction away from the bottom along a longitudinal axis (LA). The body has a surface (18) having an UV-cured matrix (20) including UV-curable varnish drops (30) arranged in a plurality of layers (50, 52) and having voids (32) existing therebetween to form a porous matrix structure (24). One method to form the glass container is to apply a layer of UV-curable varnish to an outer surface of the glass container as a plurality of varnish drops, so as to establish a plurality of voids between the varnish drops, cure the layer of UV-curable varnish, apply one or more additional layers of UV-curable varnish, and cure the additional layer(s) of UV-curable varnish, wherein all of the varnish drops and the voids form the UV-cured matrix.
Patent WO-2021007583-A3 (WO)
Inventor: SARTORI PHILIPPE
IPC: H04W76/14
Filed: 2020-10-02
Abstract: Example sidelink communication methods and apparatus are described. One example method includes determining resources for potential transmission from a resource pool on a sidelink by a terminal device. The terminal device transmits a resource indication message on the sidelink, where the resource indication message includes a configuration of the resources that are determined for potential transmission. The configuration of the resources indicates a subset of the resources that are usable by first type of user equipments (UEs) and a subset of the resources that are usable by second type of UEs. The resource indication message is sent in a sidelink control information (SCI) message. The terminal device receives an indication of selected resources from at least one second type of UE, and transmits the indication of selected resources to at least another UE.
Patent WO-2021236251-A3 (WO)
Title: Neural network-based system for flight condition analysis and communication
Inventor: HWU TIFFANY
IPC: B64D43/00
Filed: 2021-04-09
Abstract: A pilot support system includes: a processing circuit; and memory storing instructions that, when executed by the processing circuit, cause the processing circuit to: receive input data regarding a current state of a vehicle; encode the input data to generate encoded input data; supply the encoded input data to a trained statistical model; compute a current context of the vehicle based on the input data using the trained statistical model; compute one or more pilot feedback indicators based on the current context using the trained statistical model; and provide the one or more pilot feedback indicators to a cockpit of the vehicle.
Patent WO-2021212021-A3 (WO)
Inventor: MARASCO WAYNE A
IPC: C07K16/10
Filed: 2021-04-16
Abstract: La présente invention concerne des anticorps monoclonaux qui neutralisent le SRAS-CoV2 et des procédés d'utilisation de ceux-ci. Les anticorps selon l'invention peuvent être utilisés pour traiter des infections par le SRAS-CoV2 et leurs symptômes.
Patent WO-2021178982-A3 (WO)
Title: External marking material for medical imaging procedures
Inventor: KASSAB GHASSAN
IPC: A61B90/00
Filed: 2021-05-03
Abstract: The invention comprises a substance suitable for external marking of a patient's skin during a radiographic procedure, such as angiography and endovascular procedures. The substance comprises a volume of radiopaque marking substance suitable for creating a rapidly stable and precise image on a radiographic medical device when said material is placed externally on a patient and imaged by the radiographic medical device. The substance comprises a volume of forming material for combination with the radiopaque material. An associated dispenser is also disclosed.
Patent WO-2021247840-A3 (WO)
Title: Systems and methods for improved machine-learned compression
Inventor: AGUSTSSON EIRIKUR THOR
IPC: H03M7/30
Filed: 2021-06-03
Abstract: A computer-implemented method for compressing computer-readable data having improved efficiency can include obtaining, by a computing system including one or more computing devices, input data associated with the computing system; and encoding, by the computing system, the input data and added noise from a noisy channel to produce encoded data based at least in part on an encoder model, wherein encoding the input data and added noise includes additively combining the added noise and the input data to obtain noisy input data and rounding the noisy input data by a soft rounding function, the soft rounding function having a sharpness, to produce the encoded data, wherein the machine-learned encoder model is trained on training data, wherein the training data is encoded with the added noise from the noisy channel.
Patent WO-2022108931-A3 (WO)
Inventor: PETERSON SCOTT
IPC: A61P35/00
Filed: 2021-11-16
Abstract: L'invention concerne des méthodes de traitement de tumeurs solides au moyen d'une association de tucatinib, ou d'un sel ou solvate de celui-ci, et d'un anticorps anti-PD-1, ou d'un fragment liant l'antigène de celui-ci. L'invention concerne également des méthodes de traitement de tumeurs solides au moyen d'une association de tucatinib, ou d'un sel ou solvate de celui-ci, et d'un anticorps anti-PD-L1, ou d'un fragment liant l'antigène de celui-ci.
Patent WO-2022155506-A3 (WO)
Inventor: MORIDI ATIEH
IPC: C22C1/00
Filed: 2022-01-14
Abstract: The technologies disclosed herein relate to systems and methods of manufacturing an alloy. In accordance with various embodiments, the alloy produced via the disclosed systems and/or methods include engineering of duplex microstructures in the alloy to improve poor mechanical performance of additive manufactured metals. In various embodiments, the alloy may be subjected to thermo-mechanical treatment where simultaneous heat and pressure is applied with a deliberately high density of fusion defects. In accordance with various embodiments, the systems and methods disclosed in the present application have the potential to improve damage tolerance of critical structures experiencing fatigue loading and impact loading.
Patent WO-2023044042-A3 (WO)
Title: Machine à rainer les tuyaux
Inventor: MAKSIMOWSKI JOSEPH
IPC: B21D15/06
Filed: 2022-09-16
Abstract: L'invention concerne une machine à rainer les tuyaux qui comprend un ensemble de base ; une plaque de broche fixée à l'ensemble de base mais conçue pour tourner autour d'un axe par rapport à l'ensemble de base ; et une pluralité d'ensembles rouleaux fixés à la plaque de broche, chacun des ensembles rouleaux comprenant une paire de rouleaux conçus pour former une rainure dans un tuyau à proximité d'une extrémité du tuyau.
Patent WO-2023023588-A3 (WO)
Title: Methods and compositions of inhibiting asprosin mediated orexigenesis and/or glucogenesis
Inventor: CHOPRA ATUL
IPC: C07K14/005
Filed: 2022-08-18
Abstract: A method of inhibiting asprosin mediated orexigenesis and/or glucogenesis in a subject in need thereof includes administering to the subject a therapeutic peptide that includes an amino acid sequence substantially identical to an extracellular portion of the amino acid sequence of protein tyrosine phosphatase receptor type δ (PTPRD) that binds to asprosin.
Patent WO-2023147145-A3 (WO)
Inventor: DUTT NIDHI
IPC: H04W12/06
Filed: 2023-01-30
Abstract: The present invention is a system and method for secure electronic document exchange and execution of contracts and digital consent via a secure electronic platform with biometric access verification. A user receives a one-time password (OTP) via a short message service (SMS) on a mobile phone. Within a secure system, this unique temporary code is fused with the user's biometric data to create a secure tokenized digital identity which the user can utilize to electronically sign a document or provide digital consent in a mobile-first environment. Any document signed, or consent process completed, by the individual is stored within the present invention's secure servers. The user accesses the platform's secure web-based system to view, download and share via instant message, email or any other digital communication method all documents and consent materials they are a party to anywhere, anytime, in perpetuity. The present invention provides improved accessibility to digitally sign documents and provide consent.
Patent AT-521957-A4 (AT)
Title: Schonbezug für ein Sitzteil eines Kraftfahrzeugsitzes
IPC: B60N2/60
Filed: 2019-05-22
Abstract: Ein Schonbezug für ein Sitzteil (1) eines Kraftfahrzeugsitzes umfasst einen Bezugsstoff (3) zum Überdecken einer Sitzfläche des Sitzteils (1) und Spannriemen (4a, 4b) zum Befestigen des Schonbezuges am Kraftfahrzeugsitz. Der Schonbezug weist zumindest eine Öffnung (5) für an einer der seitlichen Schmalseiten des Sitzteils (1) angeordnete Funktionselemente (8) des Sitzteils (1) auf, wobei die Öffnung (5) zwischen einem Rand (3d) des Bezugsstoffs (3) und einem, vorzugsweise gummielastisch dehnbar ausgebildeten, Spannriemen (4a) liegt, welcher im Abstand unterhalb des Randes (3d) des Bezugsstoffs (3) zur Rückseite des Kraftfahrzeugsitzes verläuft.
Patent AT-518554-A4 (AT)
Title: Steuerbarer Rettungsfallschirm, Bauart Kreuzkappe
Inventor: ING THOMAS GRABNER
IPC: B64D17/34
Filed: 2016-04-28
Abstract: Der steuerbare Rettungsschirm von der Bauart einer Kreuzkappe ist ein kostengünstiges Rettungssystem, das einfach in der Handhabung ist (Steuerbarkeit) ohne der Gefahr eines unerwünschten Stalls (aerodynamischer Strömungsabriss) und einfach in der Wartung (geringer Aufwand beim regelmäßig erforderlichen Packen). Die Basis ist eine Kreuzkappe, die in konventioneller Bauart nicht als steuerbares System ausgelegt ist. Durch Diagonalanordnung über dem Piloten mit getrennten Aufhängepunkten und separaten Steuergurten entsteht ein neues steuerbares System.
Patent AT-523908-A4 (AT)
Title: Halter
Inventor: HANS-JÜRG KOWATSCH
IPC: A47J43/28
Filed: 2020-11-12
Abstract: Ein Halter (1) für einen länglichen Gegenstand, wie einen Besteckteil oder ein Küchenwerkzeug ist ein Bügel (2). An den Schenkeln (3) des Bügels sind Haken (4) vorgesehen, mit welchen der Halter (1) an dem Rand eines Gefäßes eingehängt werden kann. Ein Besteckteil oder ein Küchenwerkzeug wird auf den Steg (5) des Bügels (2) gelegt und mit einem Ende auf den oberen Rand des Gefäßes aufgelegt. Die den gekrümmten Steg (5) tragenden Enden (6) der Schenkel (3) weisen schlaufenartig abgebogene Bereiche (9) auf. Die Haken (4) haben eine abgeflachte Querschnittsform.
Patent BE-1001618-A4 (BE)
Title: Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments.
IPC: C07C239/00
Filed: 1987-07-27
Granted: 1989-12-19
Abstract: L'invention a pour objet les composés de formule dans laquelle A est l'hydrogène ou un substituant, B représente un groupe hydroxy ou un substituant, au moins un des symboles A et B devant représenter un reste peptidique, et R, R1 à R6 représentent des groupes variés, et leurs formes isostères. Les composés peuvent etre utilisés en thérapeutique comme inhibiteurs de la rénine.
Patent EP-1192562-A4 (EP)
Title: Method and apparatus for efficient proximity searching
Inventor: GOLDENSHER CHARLES
IPC: G06F17/30
Filed: 2000-01-21
Abstract: An area containing a population of points is subdivided into a plurality of regions at index time. The population of points and the regions are textual keyed. Attribute(s) are determined corresponding to at least a subset of points from the population (110). Each attribute or pair of attributes is assigned a bitmap, the bitmap having entries corresponding to the regions in the area (114). Each entry of the bitmap corresponding to a region having at least one point to which the attribute applies is set (118). The attribute is then stored in an index with its bitmap. At query time, scanning the bitmap for set bits identifies all potentially relevant regions. These regions may be searched in increasing distance from a spatial origin without incurring the cost of searching fruitless regions. <IMAGE>
Patent EP-1164863-A4 (EP)
Title: Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals
Inventor: BUI LINH M
IPC: A23K1/18
Filed: 2000-03-21
Abstract: A pet food product and process for producing the pet food product for use in maintenance of healthy joints and alleviation of arthritic symptoms in companion animals, the pet food comprising an effective amount of an active extract of Perna canaliculus. The extract can be either a powder or lipid extract. Preferably in an amount that provides for a dosage range of generally 0.18 to 114 mg of a powder extract/kg of body weight/day in a companion animal or an amount of generally 1.5 to 1000 mg of a powder extract of Perna canaliculus per 400 kcal of pet food product.
Patent EP-1180933-A4 (EP)
Title: Compositions and process for nematode control
Inventor: RODRIGUEZ-KABANA RODRIGO
IPC: A01N35/04
Filed: 2000-04-03
Abstract: Chemical compositions having superior nematicidal properties are formulated. The compositions contain one or more selected aldehydes as the major component and one or more aliphatic or cyclic isothiocyanates as a minor component. Preferred mixtures contain furfural and one or both of methyl isothiocyanate and allyl isothiocyanate. Plant-parasitic nematodes are controlled by contacting the nematodes with the nematicidal compositions, by, for example, applying the compositions to soil or other plant growth media containing the nematodes.
Patent EP-1105023-A4 (EP)
Title: Integral mounting base support for components
Inventor: LODI FRANK
IPC: F16B21/09
Filed: 2000-04-10
Abstract: A mounting support and a component integral with the support for secured mounting in a panel having a keyhole aperture, wherein the keyhole aperture has a smaller aperture intersecting with a larger aperture, and the support has a base for seating on the panel, a finger extending from the base which spans the keyhole aperture, a channel depending from the base which enters the keyhole aperture and slides from the larger aperture into the smaller aperture, a flange having a dimension no greater than the larger aperture but greater than the smaller aperture and which overlays the bottom of the panel, and an engaging member on the finger which releasably locks the support in the keyhole aperture and secures the component on the panel when the base is slid over the smaller aperture.
Patent EP-1187605-A4 (EP)
Inventor: KLOOG YOEL
IPC: A61K31/21
Filed: 2000-06-19
Abstract: L'invention concerne une méthode permettant d'inhiber la prolifération cellulaire induite ou régulée par Ras, associée à une maladie, à un trouble ou à un état pathologique non malins. Cette méthode consiste à administrer à un patient un antagoniste de Ras en quantité suffisante pour inhiber la prolifération. Cette méthode convient en particulier pour les maladies qui se caractérisent par une prolifération de lymphocytes T, telles que les maladies auto-immunes, par exemple le diabète de type I, le lupus et la sclérose en plaques, ainsi que pour des états pathologiques tels que les rejets de greffe induits par la présentation d'un antigène étranger dans le cas d'une greffe  réalisée suite à un état pathologique (p. ex. insuffisance rénale). D'autres pathologies non malignes caractérisées par une prolifération cellulaire comprennent notamment la cirrhose du foie ou la resténose. Les antagonistes de Ras préférés sont l'acide S-trans-trans farnésylthiosalicylique (FTS) et des composés structurellement voisins (ou analogues) de ce dernier.
Patent EP-1115088-A4 (EP)
Title: Method and device for displaying or searching for object in image and computer-readable storage medium
Inventor: BOBER MIROSLAW Z
IPC: G06V10/46
Filed: 2000-07-12
Abstract: A method of representing an object appearing in an image or sequence of images, by processing signals corresponding to the image or images, comprises deriving a curvature scale space (CSS) representation of the object outline by smoothing the object outline, characterised by deriving an additional parameter which represents the shape or mass distribution of a smoothed version, corresponding to a peak in the CSS image, of the original object outline, and associating the CSS representation and the additional parameter to form a shape descriptor of the object.
Patent EP-1284781-A4 (EP)
Inventor: SHEMER ITSIK
IPC: A61B5/042
Filed: 2001-05-03
Abstract: L'invention concerne un appareil (18) servant à appliquer un signal au coeur (20) d'un être humain. Cet appareil comprend au moins une électrode (98) conçue pour être couplée à la cloison interventriculaire droite. Une unité de commande (90) de l'appareil est conçue pour commander l'électrode ou les électrodes de sorte qu'elle(s) applique(nt) un signal de commande de tissu excitable (ETC) à la cloison interventriculaire (22). De préférence, l'unité de commande est conçue pour configurer le signal de sorte que ce dernier puisse modifier la contractilité d'une partie du coeur.
Patent EP-1281759-A4 (EP)
Title: Method of inhibiting the formation of by-product in the production of genetically modified polypeptide
Inventor: YABUTA MASAYUKI
IPC: C07K14/58
Filed: 2001-05-10
Abstract: A method for reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium in a method for producing a polypeptide containing a serine residue by culturing transformed cells, and a method for producing a polypeptide containing a serine residue by culturing transformed cells, characterized by reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium.
Patent EP-1305768-A4 (EP)
Inventor: GUTKOWICZ-KRUSIN DINA
IPC: A61B5/103
Filed: 2001-06-27
Abstract: Une image lumineuse est transmise à partir d'un tissu biologique interne, au moyen d'un système optique souple, à un récepteur d'images, où elle est convertie en une forme lui permettant d'être introduite dans un ordinateur. L'ordinateur segmente l'image en générant un masque de segmentation définissant la limite d'une région appropriée dans au moins une bande spectrale, estime au moins une mesure statistique invariante, en rotation et en translation, des coefficients de distribution des représentations maxima en ondelettes de grandeurs multiples d'images numériques dans au moins une bande spectrale, caractérise l'état du tissu sur la base des valeurs estimées et fournit en sortie la caractérisation de l'état du tissu.
Patent EP-1332605-A4 (EP)
Inventor: QUIBRIA NASREEN
IPC: H04M3/493
Filed: 2001-10-16
Abstract: Un système (12) d'exploitation d'une application de reconnaissance vocale téléphonique comporte un dispositif téléphonique automatisé (14) pour effectuer une liaison téléphonique avec un récepteur et un dispositif de reconnaissance vocale (16) qui, lors de la liaison téléphonique (18), présente au récepteur au moins un message-guide préliminaire auquel le récepteur doit répondre; reçoit une réponse parlée à partir du récepteur; et effectue une analyse de reconnaissance vocale sur la réponse parlée en vue de déterminer une capacité du récepteur de compléter l'application. Si le dispositif de reconnaissance vocale, en fonction de la réponse parlée au message-guide préliminaire, détermine que le récepteur est capable de compléter l'application, le dispositif de reconnaissance vocale présente au moins une message-guide d'application au récepteur. Si le dispositif de reconnaissance vocale, en fonction de la réponse parlée au message-guide préliminaire, détermine que le récepteur n'est pas capable de compléter l'application, le système de reconnaissance vocale présente des instructions concernant la mise en oeuvre de l'application au récepteur.
Patent EP-1265931-A4 (EP)
Inventor: QI HELENA
IPC: C08B37/16
Filed: 2001-12-19
Abstract: L'invention concerne un procédé destiné à porter la concentration de cyclodextrine à une valeur supérieure ou égale à 15 % en poids de façon à former des complexes au moyen d'une opération de précipitation. Ce procédé permet d'augmenter le rendement de ces complexes, d'augmenter la teneur en molécules hôtes complexées et de réduire la dimension des particules desdits complexes.