baber/WOPTO huggingface dataset:
Patent EP-3774845-A1 (EP)
Title: Macrocyclization of peptidomimetics
Inventor: SHIPMAN MICHAEL
IPC: C07K7/02
Filed: 2019-03-28
Abstract: The invention provides an improved method of macrocyclization of peptidomimetics, as measured by isolated yields and product distribution, which comprises substitution of one or more of the backbone amide C=O bonds with a turn-inducing motif. The method is general with enhancements seen across a range of ring sizes (e.g. tri-, tetra-, penta- and hexapeptides). Specifically, the invention provides a peptidomimetic macrocycle comprising a carbonyl bioisosteric turn-inducing element having the structure: (I) wherein X is a heteroatom; and wherein R 1  to R 6  are each independently selected from alkyl, aryl, heteroaryl and H.
Patent EP-3768678-A1 (EP)
Inventor: HADIAN KAMYAR
IPC: A61K31/5025
Filed: 2019-03-22
Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.
Patent EP-3774932-A1 (EP)
Inventor: SZUL JOHN F
IPC: C08F2/34
Filed: 2019-03-20
Abstract: Embodiments of the present disclosure are directed towards methods of adjusting melt index and/or density utilizing a metallocene complex represented by Formula (I): wherein each n-Pr is n-propyl, and each X is independently CH 3 , CI, Br, or F.
Patent EP-3790380-A1 (EP)
Title: Transportsystem für ein tier zur aufnahme in einem kraftfahrzeug
Inventor: KAMLAGE KARL-HEINZ
IPC: A01K1/02
Filed: 2019-05-06
Abstract: Erfindungsgemäß wird ein Transportsystem vorgeschlagen, das aufweist, einen auf einer Transportfläche (7) des Kraftfahrzeugs (3) aufnehmbaren Träger und eine Einstiegshilfe (6, 6', 6", 6"'), wobei die Einstiegshilfe mindestens ein erstes und zweites Trittelement (11) umfasst, wobei das erste Trittelement (10) derart verschwenkbar an dem Träger angelenkt ist, dass die Einstiegshilfe aus einer Transportposition in eine Einstiegsposition bewegbar ist, wobei die Einstiegshilfe in der Transportposition auf einer ersten Seite einer von dem Träger aufgespannten Ebene (9) angeordnet ist, so dass dann, wenn das Transportsystem in dem Kraftfahrzeug aufgenommen ist, die Einstiegshilfe ein Hindernis für das Tier bildet, wobei die Einstiegshilfe in der Einstiegsposition auf einer zweiten Seite der von dem Träger aufgespannten Ebene angeordnet ist, so dass dann, wenn das Transportsystem in dem Kraftfahrzeug aufgenommen ist, das Tier das Kraftfahrzeug über die Einstiegshilfe verlassen kann, wobei das erste Trittelement derart mit dem zweiten Trittelement verbunden ist, dass das erste Trittelement und das zweite Trittelement relativ zueinander zwischen einem ausgestreckten Zustand und einem verstauten Zustand bewegbar sind, und wobei das erste Trittelement und das zweite Trittelement derart mechanisch miteinander gekoppelt sind, dass ein Verschwenken der Einstiegshilfe gegenüber dem Träger aus der Transportposition in die Einstiegsposition zu einer Bewegung des ersten Trittelements gegenüber dem zweiten Trittelement aus dem verstauten Zustand in den ausgestreckten Zustand führt.
Patent EP-3797499-A1 (EP)
Inventor: IRAZABAL JERONIMO
IPC: H04L29/08
Filed: 2019-05-13
Abstract: Un exemple de fonctionnement peut inclure un ou plusieurs procédés pour fournir une soumission de transaction en une seule étape dans un réseau de chaines de blocs, consistant à envoyer une proposition de transaction, par un nœud client, à un ou plusieurs pairs d'une pluralité de pairs, simulant une transaction associée à cette proposition de transaction, par au moins un pair de la pluralité de pairs, à évaluer, par un pair approbateur, si une politique d'approbation a été réalisée et, lorsque la politique d'approbation a été réalisée, à envoyer la transaction à au moins un nœud prescripteur pour être inscrite au registre par ce pair approbateur.
Patent EP-3785400-A1 (EP)
Inventor: TEBOULLE HENRI
IPC: H04L12/10
Filed: 2019-05-27
Abstract: Un modem d'un compteur électrique intelligent (120) obtient, suite à un enregistrement dans le réseau de communication par courants porteurs en ligne (101) de type ad hoc des informations de routage ainsi que des informations de chiffrement, par échanges de messages dans le réseau de communication par courants porteurs en ligne (101). Le compteur électrique intelligent (120) sauvegarde en mémoire non volatile les informations de routage et les informations de chiffrement, les informations de routage étant sauvegardées en association avec une information représentative d'un instant auquel la sauvegarde est effectuée. Lors d'un réenregistrement ultérieur du compteur électrique intelligent (120) suite à une déconnexion du réseau de communication par courants porteurs en ligne (101), le compteur électrique intelligent (120) récupère (508, 509) les informations de routage et de chiffrement précédemment sauvegardées dans la mémoire non volatile (310), les met à jour en y supprimant toute information de route périmée, et les utilise pour communiquer dans le réseau de communication par courants porteurs en ligne (101).
Patent EP-3802137-A1 (EP)
Inventor: TAYLOR BRADLEY K
IPC: B41M1/04
Filed: 2019-05-22
Abstract: The present invention relates to a printing form for flexographic printing. The printing form contains microcell patterns on its relief printing surface. The presence of these microcell patterns allows for printing with a higher anilox roll volume. Also disclosed are five specific microcell patterns.
Patent EP-3818318-A1 (EP)
Inventor: NOGLI THORSTEN
IPC: F27D19/00
Filed: 2019-07-01
Abstract: Die vorliegende Erfindung betrifft ein Verfahren und eine Einrichtung zum Betreiben einer Produktionsanlage, in der wenigstens ein elektrische Energie intensiv verbrauchender Produktionsprozess zur Herstellung eines Produktes durchgeführt wird, welcher wenigstens zwei Prozessstufen umfasst, wobei in der jeweiligen Prozessstufe (100) erzeugte Zwischenprodukte in wenigstens einem Zwischenlager gelagert werden können, wobei insbesondere vorgesehen ist, dass die elektrische Versorgung der Produktionsanlage mittels wenigstens einer zeitlich fluktuierenden, z.B. regenerativen Energiequelle erfolgt, dass eine für den Produktionsprozess gemäß einer der wenigstens zwei Prozessstufen ausreichende elektrische Versorgung geprüft wird (105), dass bei einer ausreichenden elektrischen Versorgung der Produktionsprozess gemäß einer der wenigstens zwei Prozessstufen durchgeführt wird (110), und dass bei einer für den Produktionsprozess gemäß der einen Prozessstufe nicht ausreichenden elektrischen Versorgung des Produktionsprozesses ein in dem Produktionsprozess gemäß der einen Prozessstufe hergestelltes Zwischenprodukt zwischengelagert wird (115).
Patent EP-3810964-A1 (EP)
Inventor: GIORDANO BRUNO
IPC: F16K27/02
Filed: 2019-05-31
Abstract: Valve (1) for fluids, preferably for gases, comprising an inlet passage (2) for a fluid; an outlet passage (3) for the fluid; a shutter (4) interposed between the inlet passage (2) and the outlet passage (3) and movable along a movement direction (L) between an open position and a closed position; first magnetic attraction means (5) operatively active on the shutter (4) for attracting and/or keeping the shutter (4) itself towards the open position; a box-shaped body (7) containing the first magnetic attraction means (5) and extending along the movement direction (L) between an outer face and an inner face with respect to an inner volume (V) of the valve (1) interposed between the inlet passage (2) and the outlet passage (3). The box- shaped body (7) further comprises a dividing wall (10) for isolating the first magnetic attraction means (5) from the inner volume (V).
Patent EP-3807384-A1 (EP)
Title: Amine-functionalized organosilane / organophosphate combination systems as ep agents / corrosion inhibitors in compositions for treating metal surfaces
Inventor: KIM HOON
IPC: C10M139/04
Filed: 2019-06-13
Abstract: According to the present invention, the composition treating a metal surface, especially a metalworking fluid, comprising the reaction product of at least one amine-functionalized organosilane and at least one organophosphate and/or at least one oligomer or polymer of said reaction product, wherein the molar ratio of the amino group/s of the at least one amine-functionalized and of the at least one organophosphate is 1.0 : 0.4 to 1.0 : 1.2, and wherein the at least one amine-functionalized organosilane is linked to the at least one organophosphate by at least one phosphoric acid/amine salt bond. The present invention also includes a method for producing said composition, the use of the composition as well as a method for treating a metal surface.
Patent EP-3755406-A1 (EP)
Inventor: LYNCH CORMAC
IPC: A61M5/32
Filed: 2019-01-30
Abstract: A cover (50) is configured to enclose a pen needle or a safety pen needle (10). The cover (50) comprises a proximal end (52) in communication with an opening (58), the pen needle or the safety pen needle (10) disposed in the opening (58), a first seal (72) disposed at the proximal end (52) of the cover (50) to seal the opening (58), a cavity (56) disposed at a distal end (54) of the cover (50), a swab (60) disposed in the cavity (56), and a second seal (70) disposed at the distal end (54) of the cover (50) to seal the swab (60) in the cavity (56). The swab (60) contains at least one of an alcohol antiseptic, a non-alcohol antiseptic, and a numbing agent.
Patent EP-3759400-A1 (EP)
Inventor: SELLÖ MARTIN
IPC: F24F13/068
Filed: 2019-02-27
Abstract: The invention refers to a device for creating a variable flow in air and climate products, which can serve as air supplying means and exhaust units in a ventilation system, which device comprises two cooperating flow guiding means, a first means and a second means, wherein the first means comprises at least one first nozzle defined by inclining walls forming an opening in the bottom and an opening at the top, and the second means comprises at least one second nozzle defined by inclining walls forming an opening in the bottom and an opening at the top, and wherein the at least one first nozzle and the at least one second nozzle together forms at least one mutual nozzle whereby the airflow can be regulated by displacing at least one of the first and second means in relation to the other in a lengthwise direction, and wherein the at least one first nozzle is further provided with a tab on one end wall, forming an inner end wall of the mutual nozzle when the second means is dislocated.. The invention further refers to a ventilation system comprising such a device.
Patent EP-3764371-A1 (EP)
Inventor: URUSHIHARA MAKOTO
IPC: H01F5/00
Filed: 2019-03-01
Abstract: There is provided an insulated flat rectangular conductor (10, 20) including: a flat rectangular conductor (11); and an insulating film (15) coating the flat rectangular conductor (11), in which the flat rectangular conductor (11) has a first surface (12a) and a second surface (12b) opposite to the first surface (12a), and the first surface (12a) is rougher than the second surface (12b).
Patent EP-3766965-A1 (EP)
Inventor: FAN JING
IPC: C12N5/079
Filed: 2019-03-11
Abstract: The present invention provides a method for preparing 3D brain organoids, comprising the following steps: neurospheres obtained by the RONA method are dissociated into single cells by accutase, plated on a cell culture plate after being counted, cultured in medium A until day 7; neurospheres are cultured in medium B until day 25∼35, and then they are encapsulated by Matrigel; neurospheres are further cultured in media B until day 55∼65, and then they are encapsulated by Matrigel for the second time and cultured continually afterwards. The present invention also provides a medium for culturing 3D brain organoids. The present invention begins with highly purified neurospheres obtained by the RONA method, and neuronal stem cells can be controlled and cultured to achieve true 3D brain organoids with uniform size and structure by this relatively simple method. The 3D brain organoids have six-layered cortical structure of the brain and various subtypes of inhibitory interneuron cells, which are suitable for disease research  in vitro,  drug screening,  etc.,  and are of great significance in industrialization.
Patent EP-3863921-A1 (EP)
Inventor: DUBOSC GRÉGORY
IPC: B64C1/14
Filed: 2019-10-07
Abstract: This invention concerns a door (3) of an aircraft (1) equipped with an opening/closing mechanism, the movement of which in a main horizontal plane (P) of the aircraft (1) is controlled by coupling between the door (3) and the frame (4) on a control (7) and on two front (AV) and rear (AR) guides (8, 9), arranged between the respective front (AV) and rear (AR) door parts (3), and the frame (4) coupled to at least one handling arm (5, 6) hinged in rotation on a front side (AV) of the frame (4) and to the door (3) via a forearm (5b, 6b).
Patent EP-3773695-A1 (EP)
Title: Stable antibody formulation
Inventor: JAYARAMAN MURALI
IPC: A61K47/00
Filed: 2019-04-10
Abstract: The present invention discloses a stable pharmaceutical formulation of an antibody, wherein the formulation contains buffer, surfactant and salt, and wherein the formulation is devoid of free amino acids. The disclosed antibody formulations are liquid formulations that are also suitable for lyophilization.
Patent EP-3861424-A1 (EP)
Inventor: HAJIMIRZA NAVID
IPC: G06F3/01
Filed: 2019-10-03
Abstract: Systems and methods for collecting visual attention information are described. The methods comprise the steps of displaying a browser window on a display (210); estimating a user's (220) gaze point within the display (210); transforming the geometry of the estimated gaze point and/or the geometry of the browser window to a common coordinate system; identifying an object (215) in the browser window that corresponds to the estimated gaze point; and storing the estimated gaze point and data corresponding to the identified object (215).
Patent EP-3852843-A1 (EP)
Inventor: BARMAIMON EYAL
IPC: A61M5/315
Filed: 2019-10-11
Abstract: An automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the insertion needle, and a drive system configured to cause linear movement of the plunger to force the pharmaceutical product into the fluid path. The passive drive system has a movable element. The movable element has a shape memory alloy and is configured to change shape to move the plunger.
Patent EP-3787096-A1 (EP)
Inventor: OKUMURA MASASHI
IPC: H01M10/48
Filed: 2019-04-05
Abstract: Disclosed is a power supply device including a battery having an exhaust valve that opens when an internal pressure becomes higher than a set pressure, the battery being housed in a case, a temperature sensor that detects a temperature in the case, and a detection circuit that detects opening of the exhaust valve at a detected temperature detected by the temperature sensor. In this power supply device, the detection circuit detects that a high temperature time (t1) from a timing at which a rate of rise (ΔT/Δt) of the temperature detected by the temperature sensor is higher than a rise rate set value and exceeds the rise rate set value to a timing at which the detected temperature falls to less than or equal to a reference temperature is longer than a high temperature time set value, and detects the opening of the exhaust valve.
Patent EP-3714331-A1 (EP)
Inventor: KAZIEV BORIS
IPC: C07C11/04
Filed: 2019-04-30
Abstract: La présente invention concerne un procédé d'impression électrophotographique comprenant l'impression électrophotographique d'une composition électrophotographique liquide sur un substrat. La composition électrophotographique liquide comprend un adjuvant de charge et un copolymère a) d'éthylène et b) d'acide méthacrylique et/ou d'acide acrylique, 80 à 95 % en poids des unités dudit copolymère étant dérivés de l'éthylène. Le substrat imprimé est ensuite soumis à un rayonnement de faisceau d'électrons (EB).
Patent EP-3874092-A1 (EP)
Title: Breitstreckwalze
Inventor: ROSSENBACH ANDREAS
IPC: D21F1/40
Filed: 2019-10-31
Abstract: Vorrichtung mit einer Breitstreckwalze (2), die ein Walzenrohr (3) aufweist, über das eine Materialbahn geführt ist, wobei diese durch eine Verbiegung der Breitstreckwalze (2) um ihre Längsachse breitsteckbar ist, mit zwei Lagerzapfen (4), die mit dem Walzenrohr (3) in Wirkverbindung stehen und in einem Maschinengestell (1) schwenkbar angelenkt sind, wobei die Lagerzapfen (4) mittels schwenkbarer Lager (6) am Maschinengestell (1) gelagert sind und diese die Lager (6) überragende Längszapfen (5) aufweisen, an deren Enden radial angreifende Verstellmittel (7) angeordnet sind.
Patent EP-3867046-A1 (EP)
Inventor: REESE RILEY
IPC: B29C70/34
Filed: 2019-10-15
Abstract: Rib-and-sheet structures include a rib comprising continuous, aligned fibers. The rib is fabricated via compression molding from continuous, aligned fiber, thereby providing an aligned, continuously reinforced rib. In one embodiment, rib-and-sheet structures are produced in a two-step compression-molding process, wherein a near net-shape rib is molded, in a first mold, from fiber-bundle based preforms, and then a rib-and-sheet part is molded by placing, in a second mold, the rib with either: (i) a preformed sheet, (ii) plies that form a laminate/sheet or (iii) chopped fibers that form a sheet during the molding process. In another embodiment, rib-and-sheet structures are fabricated in a one-step compression- molding process, wherein fiber-bundle-based preforms and (i) a preformed sheet, (ii) plies that form a laminate/sheet, or (iii) chopped fibers are combined in a single mold and molded in a single step.
Patent EP-3792996-A1 (EP)
Inventor: TSURUTA SHOGO
IPC: H01M50/569
Filed: 2019-04-24
Abstract: An energy storage apparatus (10) includes an energy storage device (21) having terminals (27, 28), a bus bar (33A) connected to the terminals (27, 28), and a circuit board (78) electrically connected to the bus bar (33A). The bus bar (33A) has a bus bar body (36) fixed to the terminals (27, 28), a protruding portion (39) protruding from the bus bar body (36), and a board connecting part (49) protruding from the protruding portion (39) and fixed to the circuit board (78). A lateral width (W1) of the board connecting part (49) is narrower than a lateral width (W3) of the protruding portion (39). At a base end of the board connecting part (49), a seat (50) is formed whose lateral width is gradually narrowed from the protruding portion (39) toward a tip end of the board connecting part (49).
Patent EP-3877799-A1 (EP)
Inventor: TAJAN FLORENT
IPC: G02B26/08
Filed: 2019-11-07
Abstract: The invention proposes a pointing device (1) comprising: - a first mirror (10) arranged to reflect rays respectively from or to a fixed point; - a first actuator (12) adapted to rotate the first mirror about a first axis (X-X) directed towards the fixed point; - a second mirror (20) arranged to reflect rays reflected by the first mirror towards a moving target; and - a second actuator (22) adapted to rotate the second mirror about a second axis (Y-Y), oriented towards the first mirror, the first actuator being adapted to rotate the second actuator and the second mirror about the first axis, at least one actuator being disposed on the opposite side of the mirror that it drives relative to its main reflective face, and the axes of the two mirrors together forming an angle of between 60° and 75°.
Patent EP-3809107-A1 (EP)
Inventor: SHINODA SHIGEKI
IPC: F17D5/06
Filed: 2019-06-13
Abstract: The present invention more efficiently discriminates between the presence and absence of leakage. An oscillation measurement unit (32) measures an oscillatory waveform for a measurement time using a measurement time determination unit (31) and at least two sensors provided to piping, a cross-correlation function calculation unit (33) calculates a cross-correlation function of the measured oscillatory waveform, a peak detection unit (34) detects a peak of the cross-correlation function two or more times in the measurement time, and a leakage discrimination unit (35) discriminates that leakage is present when a peak is repeatedly detected for the measurement time.
Patent EP-3809144-A1 (EP)
Inventor: INOUE YASUHIKO
IPC: G01R19/175
Filed: 2019-04-10
Abstract: Sampling timings at a plurality of measurement points at which waveform data of a power line is sampled are easily synchronized to each other. A measurement device includes: a sampling unit configured to sample a waveform of at least one of a voltage and a current at a measurement point of a power line at a predetermined sampling timing; a processing unit configured to execute processing of the waveform sampled by the sampling unit; a time information acquisition unit configured to acquire time information from a time information provision device that is communicatively connected through a network; and an adjustment unit configured to adjust a processing timing of the processing on the basis of the time information acquired by the time information acquisition unit.
Patent EP-3811060-A1 (EP)
Inventor: CHENG KA WING
IPC: A61K49/00
Filed: 2019-06-21
Abstract: L'invention concerne un procédé de distinction mutuelle de cellules cancéreuses et de cellules saines d'un sujet l'un comprenant les étapes suivantes : (i) mettre en contact une région de tissu d'un sujet suspecté de porter au moins certaines cellules cancéreuses avec une pluralité de nanodiamants, la pluralité de nanodiamants comprenant une première pluralité de conjugués, les conjugués de la première pluralité de conjugués étant constitués de premiers nanodiamants et d'au moins un agent ciblant des cellules cancéreuses, les premiers nanodiamants ayant un premier type de centre coloré, et une seconde pluralité de conjugués, les conjugués de la seconde pluralité de conjugués étant constitués de seconds nanodiamants et d'au moins un agent de ciblage de cellules saines, les seconds nanodiamants ayant un second type de centre coloré ; et (ii) appliquer une lumière d'une première longueur d'onde, de façon à exciter le premier type de centre coloré, et appliquer une lumière d'une seconde longueur d'onde, de façon à exciter le second type de centre coloré, et lors de la mise en contact de la région de tissu avec la pluralité de nanodiamants, des cellules cancéreuses sont collées à la première pluralité de conjugués tandis que des cellules saines sont collées à la seconde pluralité de conjugués ; et lors de l'application de lumière à la région de tissu, les centres colorés des nanodiamants de la première pluralité de conjugués adhérant aux cellules cancéreuses émettent une fluorescence à une première longueur d'onde tandis que les centres colorés des nanodiamants de la seconde pluralité de conjugués adhérant à des cellules saines émettent une fluorescence à une seconde longueur d'onde ; et le contraste de couleur entre les deux longueurs d'onde et les positions de conjugués respectifs délimitent la zone de cellules cancéreuses et la zone de cellules saines l'une de l'autre.
Patent EP-3809240-A1 (EP)
Inventor: YOKOYAMA RYO
IPC: G06F3/01
Filed: 2019-06-05
Abstract: The present disclosure relates to an information processing apparatus, an information processing method, and a program that can efficiently transmit a tactile signal for a plurality of tactile presentation units. 
     A transmission apparatus breaks up a tactile signal included in content into a base tactile signal group, converts the base tactile signal group into encoded data including parameters defined for each of the broken up base tactile signals, and transmits the encoded data. A reception apparatus restores and combines the base tactile signals based on the parameters included in the encoded data to restore the tactile signal and makes a tactile presentation. The present disclosure can be applied to a content reproduction system including a tactile presentation apparatus.