Patent SG-11201808388Q-A (SG)
Title: Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Inventor: BOYLAN JOHN
IPC: C07D473/26
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/173206 Al 5 October 2017 (05.10.2017) WIPO I PCT 111111111111110111010101111101011111011101011111011101011011111111111111110111111 (51) International Patent Classification: A61K 31/52 (2006.01) CO7D 473/02 (2006.01) A61K 31/505 (2006.01) CO7D 473/26 (2006.01) A61K 31/519 (2006.01) CO7D 473/32 (2006.01) (21) International Application Number: PCT/US2017/025252 (22) International Filing Date: 31 March 2017 (31.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/317,412 1 April 2016 (01.04.2016) US (71) Applicant: SIGNAL PHARMACEUTICALS, LLC [US/US]; 10300 Campus Point Drive, Suite 100, San Diego, CA 92121 (US). (72) Inventors: BOYLAN, John, F.; 10486 Harvest View Way, San Diego, CA 92128 (US). BRAY, Gordon, L.; 301 Main Street, Unit 8c, San Francisco, CA 94105 (US). FILVAROFF, Ellen; 538 18th Avenue, San Francisco, CA 94121 (US). HUBBARD, Robert; 7684 Marker Road, San Diego, CA 92087 (US). MIKOLON, David; 6140 Calle Empinada, San Diego, CA 92120 (US). RAYMON, Heather; 3520 Vista de la Orilla, San Diego, CA 92117 (US). SHI, Tao; 4650 Tarantella Lane, San Diego, CA 92130 (US). TRAN, Tam, M.; 8953 Libra Drive, San Diego, CA 92126 (US). TSUJI, Toshiya; 4171 Donald Court, San Diego, CA 92117 (US). WONG, Lilly, L.; 871 Viva Court, Solana Beach, CA 92075 (US). XU, Suichan; 9650 Deer Trail Place, San Diego, CA 92127 (US). ZHU, Dan; 4432 Calle Mar De Armonia, San Diego, CA 92130 (US). (74) Agents: BRUNER, Michael, J. et al.; Jones Day, 250 Ve- sey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, [Continued on next page] (54) Title: SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH (57) : Provided herein are methods for treating or preventing a cancer, including solid tumors and hematologic- al cancers, comprising administering an effective amount of aminopurine compounds of formula (I), and compositions comprising an effective amount of such compounds. (I) W O 20 1717 / 3 206 Al FIG. 1 WO 2017/173206 Al MIDEDIMOMOIDEIRMEMOMMEIIMMIMERVOIMIE NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))