Patent SG-11201803956U-A (SG)
Title: Anti-dr5 antibodies and methods of use thereof
Inventor: OVERDIJK MARIJE
IPC: C12N15/13
Filed: 2016-12-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ..... ...s,„,„1 (43) International Publication Date r 8 June 2017 (08.06.2017) W I P0 1 PCT ID Hit (10) 1111111111111111111 WO International Ell 1111111111 2017/093448 Publication 11111111111111111111111RIIIIIIIIIIIIIII Number Al (51) International Patent Classification: (74) Agent: GENMAB A/S; Bredgade 34 E, 1260 Copenhagen C07K 16/28 (2006.01) A61K 39/395 (2006.01) K (DK). C07K 16/30 (2006.01) C12N 15/13 (2006.01) CO7K 16/46 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/EP2016/079518 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 1 December 2016 (01.12.2016) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (25) Filing Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (30) Priority Data: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, PA 2015 00771 1 December 2015 (01.12.2015) DK ZW. PA 2015 00787 7 December 2015 (07.12.2015) DK (84) Designated States (unless otherwise indicated, for every PA 2015 00788 7 December 2015 (07.12.2015) DK kind of regional protection available): ARIPO (BW, GH, PA 2016 00701 10 November 2016 (10.11.2016) DK GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, PA 2016 00702 10 November 2016 (10.11.2016) DK TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: GENMAB B.V. [NL/NL]; Yalelaan 60, 3584- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, CM Utrecht (NL). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — (72) Inventors: OVERDIJK, Marije; C/O Genmab B.V., SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Yalelan 60, NL 3584-CM Utrecht (NL). STRUMANE, GW, KM, ML, MR, NE, SN, TD, TG). Kristin; C/O Genmab B.V., Yalelaan 60, 3584-CM Published: Utrecht (NL). RADEMAKER, Rik; C/O Genmab B.V., Yalelaan 60, 3584-CM Utrecht (NL). BREIJ, Esther; C/O — with international search report (Art 21(3)) Genmab B.V., Yalelaan 60, 3584-CM Utrecht (NL). — before the expiration of the time limit for amending the SCHUURMAN, Janine; c/o Genmab B.V., Yalelaan 60, claims and to be republished in the event of receipt of 3584 CM Utrecht (NL). PARREN, Paul; C/O Genmab amendments (Rule 48.2(h)) B.V., Yalelaan 60, 3584-CM Utrecht (NL). — with sequence listing part of description (Rule 5.2(a)) Il .4t GC i t i t M Cr \ O (54) Title: ANTI-DRS ANTIBODIES AND METHODS OF USE THEREOF IN (57) : The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DRS 1-1 c:::, antigen. The invention relates in particular to DRS-specific antibody molecules of the IgG1 isotype having a mutation in the Fc re - N gion that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DRS signalling, apop - 0 tosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DRS. The in - vention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these composi - 5. tions.