baber/WOPTO huggingface dataset:
Patent IL-114909-A0 (IL)
Title: Immunoconjugates and humahized antibodies specific for b-cell lymphoma and leukemia cells
IPC: C07K16/30
Filed: 1995-08-11
Abstract: A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kappa and IgG<SUB>1 </SUB>constant region domains, respectively, which retains the immunospecificity and B-cell lymphoma and leukemia cell internalization capacity of the parental murine LL2 monoclonal antibody, and which has the potential of exhibiting reduced human anti-mouse antibody production activity. A humanized LL2 monoclonal antibody is described in which the CDRs of the light and heavy chains have been recombinantly joined to a framework sequence of human light and heavy chains variable regions, respectively, and subsequently linked to human kappa and IgG<SUB>1 </SUB>constant region domains, respectively, which retains the immunospecificity and B-lymphoma and leukemia cell internalization capacities of the parental murine and chimeric LL2 monoclonal antibodies, and which has the potential for exhibiting reduced human anti-mouse antibody production activity. Vectors for producing recombinant chimeric and humanized chimeric monoclonal antibodies are provided. Isolated DNAs encoding the amino acid sequences of the LL2 variable light and heavy chain and CDR framework regions are described. Conjugates of chimeric and humanized chimeric LL2 antibodies with cytotoxic agents or labels find use in therapy and diagnosis of B-cell lymphomas and leukemias.
Patent IL-129547-A0 (IL)
Title: Pharmaceutical compositions comprising a macrolide and an acid
IPC: A61K31/435
Filed: 1999-04-22
Abstract: This invention provides a microemulsion pre-concentrate comprising a difficultly soluble agent and a carrier medium comprising: 1) a hydrophilic phase which comprises dimethyisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporine or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.
Patent IL-133257-A0 (IL)
Title: Systems for treating fractured or diseased bone using expandable bodies
IPC: A61M25/00
Filed: 1998-06-01
Abstract: A system for treating a vertebral body having an interior volume occupied, at least in part, by cancellous bone is described. The system comprises a first access tool that is sized and configured to establish a first percutaneous access path into the interior volume of the vertebral body, and a second access tool that is sized and configured to establish a second percutaneous access path to the interior volume of the same vertebral body, the second access path being different than the first access path. At least one void forming tool is provided that is sized and configured to be introduced individually through a selected one of the first and second access tools into the interior volume to be enlarged to form a first void in the cancellous bone after introduction through the first access tool and to form a second void in the cancellous bone different than the first void after introduction through the second access tool.
Patent IL-138353-A0 (IL)
Title: Assay methods
IPC: C12N1/19
Filed: 1999-03-26
Abstract: The present invention relates to an automated format for the yeast two hybrid assay for protein-protein interactions.
Patent IL-139757-A0 (IL)
Title: Tantalum-silicon alloys and products containing the same and processes of making the same
IPC: C22F1/00
Filed: 1999-05-20
Abstract: An alloy comprising tantalum and silicon is described. The tantalum is the predominant metal present. The alloy also has a uniformity of tensile strength when formed into a wire, such that the maximum population standard deviation of tensile strength for the wire is about 3 KSI for an unannealed wire at finish diameter and about 2 KSI for an annealed wire at finish diameter. Also described is a process of making a Ta-Si alloy which includes reducing a silicon-containing solid and a tantalum-containing solid into a liquid state and mixing the liquids to form a liquid blend and forming a solid alloy from the liquid blend. Another process of making a Ta-Si alloy is described which involves blending powders containing tantalum or an oxide thereof with powders containing silicon or a silicon-containing compound to form a blend and then reducing the blend to a liquid state and forming a solid alloy from the liquid state. Also, a method of increasing the uniformity of tensile strength in tantalum metal, a method of reducing embrittlement of tantalum metal, and a method of imparting a controlled mechanical tensile strength in tantalum metal are described which involve adding silicon to tantalum metal so as to form a Ta-Si alloy.
Patent IL-143561-A0 (IL)
Title: Improved process for preparing substituted pyridines
IPC: C07D213/80
Filed: 2001-06-05
Abstract: A process for the production of substituted pyridines comprises reaction of a substituted 1,4-dihydropyridine with methylnitrite in the presence of acids that contain less than 20 wt.% oxidizing components. A process for the production of substituted pyridines of formula (I) comprises reaction of a substituted 1,4-dihydropyridine of formula (II) with methylnitrite in the presence of acids that contain less than 20 wt.% oxidizing components. R<1>, R<5> = 1-10C alkyl or 6-10C aryl; R<2>, R<4> = H, 1-10C alkyl, CN or COOR<6>; R<3> = H, 1-10C alkyl optionally substituted by halo, NO2, COOR<6>, CN or 1-10C alkyl substituted 6-10C aryl; and R<6> = 1-10C alkyl.
Patent IL-146240-A0 (IL)
Title: Integrated multipane window unit and sash assembly and method for manufacturing the same
IPC: E06B3/24
Filed: 2000-05-05
Abstract: A multipane window unit is provided in which a sash frame is formed having an integral spacing structure (24) upon which glazing panes (30) are affixed directly thereto. The integral spacing structure (24) is formed integral with the sash frame forms at vertical internal glazing surfaces (26). Adhesive (28) can be affixed to the vertical internal glazing surface (26) to attach the glazing panes (30). In this manner, a rigid, structural sash frame can be formed prior to attachment of the glazing panes (30), thereby eliminating the need for using separately manufactured insulating glass units while obtaining similar and improved benefits. <IMAGE>
Patent IL-149890-A0 (IL)
Title: Tnt-alpha antagonist and lfa-1 antagonist for treating lfa-1 or tnf-alpha mediated
IPC: A61P9/00
Filed: 2000-12-14
Abstract: The present invention relates to a method for the treating an LFA-1 mediated disorder or a TNF-alpha mediated disorder by administering effective amounts of an LFA-1 antagonist and a TNF-alpha antagonist.
Patent IL-150443-A0 (IL)
Title: Antiseptic tampon and preparation method
IPC: A61L15/50
Filed: 2000-12-26
Abstract: The invention relates to an antiseptic tampon and a method of preparing it, which method consists of introducing metered quantities of a liquid mixture of antiseptic product and hydrophobic excipient into individual sheaths ( 14 ) for packaging tampons, then introducing standard tampons ( 22 ) into said sheaths ( 14 ) so that their lower ends are immersed in the mixture of antiseptic product and excipient, and then closing and sealing said sheaths ( 14 ).
Patent IL-150481-A0 (IL)
Title: 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors
IPC: C07D213/89
Filed: 2001-01-25
Abstract: The invention relates to the use of 2-amino-nicotinamide derivatives of formula I   
wherein n is from 1 up to and including 6; 
W is O or S; 
R 1  and R 3  represent independently of each other hydrogen, lower alkyl or lower acyl; 
R 2  represents a cycloalkyl group, an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; 
R and R' are independently of each other hydrogen or lower alkyl; 
X represents an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; 
or a N-oxide, a possible tautomer thereof or a pharmaceutically acceptable salt of such a compound, 
alone or in combination with one or more other pharmaceutically active compounds for the preparation of a pharmaceutical composition for use for therapy of a disease which responds to an inhibition of the VEGF-receptor tyrosine kinase activity; 
and to new 2-amino-nicotinamide derivatives of formula I and processes for the preparation thereof.
Patent IL-152328-A0 (IL)
Title: Mixture of defibrotide and g-csf and its use for activating haematopoietic progenitors
IPC: A61K38/19
Filed: 2001-04-10
Abstract: A description is given of a method of increasing the amount of stem cells and progenitor cells in the peripheral blood of a mammal; the method is characterised by the administration of defibrotide in combination or in temporal proximity with at least one haematopoietic factor, (preferably G-CSF) having the capacity to mobilise haematopoietic progenitors.
Patent IL-160437-A0 (IL)
Title: INDENO [1,2-c] ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IPC: A61K31/5377
Filed: 2002-08-30
Abstract: The invention provides novel classes of substituted indeno[1,2-c]isoquinoline compounds. Pharmaceutical compositions and methods of making and using the compounds are also described.
Patent IL-181406-A0 (IL)
Title: Multichannel decorrelation in spatial audio coding
Filed: 2007-02-18
Abstract: Each of N audio signals are filtered with a unique decorrelating filter (38) characteristic, the characteristic being a causal linear time-invariant characteristic in the time domain or the equivalent thereof in the frequency domain, and, for each decorrelating filter characteristic, combining (40, 44, 46), in a time and frequency varying manner, its input (Zi) and output (Z-i) signals to provide a set of N processed signals (X i). The set of decorrelation filter characteristics are designed so that all of the input and output signals are approximately mutually decorrelated. The set of N audio signals may be synthesized from M audio signals by upmixing (36), where M is one or more and N is greater than M.
Patent IL-182952-A0 (IL)
Title: Apparatus for applying a liquid to a passing web
Filed: 2007-05-03
Abstract: Shield straps (4) are interposed between the contact region (3) of a coating roller (2) and the surface of a web (1). An adjusting device (5) moves the straps in a direction perpendicular to the web running direction (D) so that the straps serially adjoin, space apart, or partly overlap with each other. At the adjoining positions, the straps block application of coating liquid from the roller to the web surface. The straps are also attached to installation clips (7).
Patent RO-129016-A0 (RO)
Title: Process and installation for producing energy and for energy charging of masses with a post-compressed air stream
Inventor: PROFIR CONSTANTIN
IPC: F02C6/00
Filed: 2013-07-17
Abstract: The invention relates to a process and an installation for producing energy and for energy charging of some masses with a post-compressed air stream, said energy being used to produce mechanical work. According to the invention, the process consists in producing mechanical and hydraulic energy and charging with energy some masses, in special installations, with a post-compressed air stream resulting from its own post-compression, the air stream being used in closed circuit, and the driving fluid, i.e. the post-compressed air, acting upon the working fluid, i.e. the mass, either directly or by means of some liquids, after use the air stream being recycled by decompression, while the controls and monitoring are provided by a computer-assisted electronic equipment. The claimed installation for carrying out the process comprises a compressor (1) for the post-compression of air, a reservoir (2) wherein there is made an intake air cushion, a reservoir (3) wherein the working pressure is achieved, a pipe network (4), some fittings (5) and an energy generator (10), where the compressor (1) intakes air from the reservoir (2), post-compresses and injects the same into the generator (10), through the reservoir (3), and, from the generator (10), the air stream is discharged into the reservoir (2).
Patent RO-133928-A0 (RO)
Title: Process for preparing a dye as powder based on carboxyhemoglobin (), to be used for obtaining common meat preparations
Inventor: ALEXE PETRU
IPC: A23L5/43
Filed: 2018-12-13
Abstract: The invention relates to a process for obtaining a carboxyhemoglobin-based dye for common meat preparations. The claimed process consists in complexing the hemoglobin from an erythrocyte concentrate with carbon oxide in a controlled manner, said concentrate being brought to the blood concentration by replacing the plasma with an isotonic sodium chloride solution and lyophilizing the so-obtained mixture, resulting in a dye as bright red fine powder.
Patent RO-134489-A0 (RO)
Title: Single-jet/multijet direct interior cooling networks for modular milling cutters
Inventor: ROŞCA DORIN - MIRCEA
IPC: B23C5/28
Filed: 2020-06-19
Abstract: The invention relates to a single-jet/multijet direct interior cooling network for a modular milling cutter, to be used in the chip-removal cutting field. According to the invention, the network has several sections wherein a cooling-lubricating liquid enters through an area (A) into an annular space (a) between a grooved shaft (1) of a modular facing mill and a screw (4), passes through some radial holes (b) of the central shaft (1) and reaches to some elementary cutting discs (2) which are provided with a network of precisely oriented holes so that when the cutting liquid exits through some orifices (c), every jet reaches in the middle area of the active cutting edges of all the cutting plates, the proper operation and the sealing being achieved by means of spacing rings (3) and an annular rubber gasket (5) .
Patent MC-1833-A1 (MC)
Inventor: HARRY ALBRECHT
IPC: C07D501/34
Filed: 1987-07-02
Abstract: Cephalosporin derivatives of the formula <IMAGE> in which m represents 0, 1 or 2, R<1> represents hydrogen or an acyl group, R<2> represents hydrogen, lower alkoxy, amino, lower alkylthio or lower alkanoylamino, R<3><1> represents hydrogen, lower alkyl, lower alkenyl, C3-C7-cycloalkyl, halogen-lower alkyl or halophenyl; Z represents R<3><0>-C or nitrogen, R<3><0> represents hydrogen or halogen, or R<3><0> and R<3><1> together represent a C3-C5-alkylene group, a C2-C4-alkylene- monooxy group or a C1-C2-alkylenedioxy group, R<3><2> represents hydrogen, halogen, lower alkyl or an optionally substituted 5- or 6-membered heterocyclic ring having one, two or three oxygen, nitrogen and/or sulphur atoms and R<3><3> represents hydrogen or halogen or R<3><2> and R<3><3> together represent a C1-C4-alkylenedioxy group, and easily hydrolysable esters and salts of these compounds and hydrates of the compounds of the formula I or of their esters and salts are described. The products have antimicrobial activity.
Patent ZW-2293-A1 (ZW)
Title: Herbicides
Inventor: PAUL ALFRED CAIN
IPC: A01N43/80
Filed: 1993-02-04
Abstract: 4-Benzoyl isoxazole derivatives of general formula (I): <CHEM>     wherein     R represents a hydrogen atom or a group -CO2R<5>; R<1> represents methyl, isopropyl, cyclopropyl or 1-methylcyclopropyl;     R<2> represents -S(O)nR<5><1>; R<3> represents a chlorine, bromine or fluorine atom, a straight- or branched- chain alkyl, alkoxy, haloalkyl or haloalkoxy group, an alkenyl group or a methyl or ethyl ester group; R<4> represents a chlorine, bromine or fluorine atom; an alkyl, alkoxy haloalkyl, haloalkoxy, -S(O)pR<5><3> or cyano group;     R<5> represents an alkyl or haloalkyl group;     R<5><1> and R<5><3> independently represent an alkyl group, and     n and p independently represent zero, one or two, and their use as herbicides is described.
Patent ZW-5793-A1 (ZW)
Title: Synergistic composition and process for selective weed control
Inventor: HANS GUT
IPC: A01N47/36
Filed: 1993-05-05
Abstract: Herbicidal composition comprising N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-urea of the formula I    <IMAGE>  (I)  or agrochemically tolerated salts thereof, and a synergistic amount of another active substance 3,5-dibromo-4-hydroxybenzonitrile of the formula II    <IMAGE>  (II)
Patent MA-27013-A1 (MA)
Title: Nouveaux derives de l' imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
Inventor: RAULT SYLVAIN
IPC: A61K31/402
Filed: 2003-10-09
Abstract: NOUVEAUX DERIVES DE L'IMIDAZOLINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composés de formule (I) : dans laquelle : - R1 représente un groupement hétéroaryle éventuellement substitué, - R2 représente un groupement cycloalkyle éventuellement substitué, - R3 représente un atome d'hydrogène ou un groupement alkyle, - R4 et R sont tels que définis dans la description, leurs énantiomères, diastéréoisomères, tautomères, ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Médicaments.
Patent MA-27626-A1 (MA)
Title: Nouveaux derives de 2-pyridinecarboxamide
Inventor: NISHIMURA TERUYUKI
IPC: A61P25/00
Filed: 2005-08-24
Abstract: La présente invention concerne un composé qui a un effet activateur de la glucokinase et est utile comme agent thérapeutique contre le diabète sucré, étant représenté par une formule (I): [dans laquelle X1 représente un atome d'azote, atome de soufre, atome d'oxygène ou ceux semblables; R1 représente un groupement aryle de 6 à 10 éléments, groupement hétéroaryle de 5 à 7 éléments ou ceux semblables; D représente un atome d'oxygène ou atome de soufre; R2 et R3 sont les mêmes ou différents, chacun représentant un atome d'hydrogène, groupement alkyle inférieur ou ceux semblables; une formule (II) représente un groupement hétéroaryle facultativement substitué de 5 à 7 éléments ou ceux semblables; une formule (III) représente un groupement monocyclique ou bicyclique] ou un sel pharmaceutiquement acceptable de celui-ci.
Patent MA-39349-A1 (MA)
Title: Système de gestion de l'intégrité permettant de gérer et de commander des données entre des entités dans une chaîne d'alimentation en pétrole et gaz
Inventor: FINKEL CHARLES
IPC: G06Q40/00
Filed: 2015-06-08
Abstract: L'invention se rapporte d'une manière générale à un système et à un procédé permettant de gérer et de commander des données entre des entités dans une chaîne d'alimentation en pétrole et gaz et, en particulier, à un système de gestion d'accise et à un procédé permettant d'identifier et de concilier des enregistrements fiscaux, des volumes de production et des rapports d'exploitation. Un système de gestion de données collecte des premières données capturées depuis un capteur ou un collecteur de données et des secondes données fournies par une filiale ou franchise ou un prestataire tiers. Le système de gestion de données fixe et regroupe les premières données pour générer un rapport fiscal sécurisé ou une estimation des taxes ou des informations fiscales se rapportant à un indicateur de performance clé (kpi pour key performance indicator) et fixe et regroupe les secondes données pour générer des données sécurisées ou un rapport financier sécurisé associé à la filiale ou à la franchise ou au contractant tiers ou à la chaîne d'alimentation en pétrole et gaz.
Patent MA-39684-A1 (MA)
Title: Module de câblage
Inventor: TOYA KAZUMASA
IPC: H01L31/054
Filed: 2015-07-06
Abstract: La présente invention concerne un module de câblage (49) qui comprend : une carte de câblage (69) ; une partie de base (38) sur laquelle est agencée la carte de câblage (69) ; et une couche d'adhérence (59) qui fait adhérer la carte de câblage (69) à la partie de base (38). La carte de câblage (69) comprend : une partie pastille (60) sur laquelle est monté un élément de génération de puissance (19) ; et une partie de câblage (63) qui est électriquement connectée à l'élément de génération de puissance (19). La couche d'adhérence (59) possède : une région d'adhérence (50) de pastille qui fait adhérer la partie pastille (60) à la partie de base (38) ; et une région d'adhérence (53) de câblage qui fait adhérer la partie de câblage (63) à la partie de base (38). La largeur de la région d'adhérence (53) de câblage est plus petite que la largeur de la région d'adhérence (50) de pastille.
Patent MA-58728-A1 (MA)
Title: Unité de chauffage
Inventor: KOHEN YUSUF
IPC: F28D1/00
Filed: 2021-05-06
Abstract: La présente invention concerne une unité de chauffage (30) pour chauffer des chambres de transport (20), un fluide transport pouvant y être stocké, et qui peut transporter un fluide d'un emplacement à un autre emplacement au moyen d'un véhicule. L'amélioration repose sur le fait que l'unité de chauffage de matière (30) comprend au moins un corps souple (31), pouvant être rempli de vapeur chaude, et au moins un élément de support (37) positionné dans ledit corps souple (31) ; pour être positionné entre la chambre de transport (20) et la paroi interne du contenant (10).
Patent UY-23848-A1 (UY)
Title: Articulo absorbente el cual incluye material superabsorbente y fibras hidrofilicas localizadas en bolsas discretas
Inventor: WILLIAN SEAL POMPLUN
IPC: A61F13/53
Filed: 1994-10-28
Abstract: Artículo absorbente, que comprende: una primera capa portadora permeable al líquido y por lo menos una segunda capa portadora; unos medios de sujeción de portador para asegurar juntas las capas portadoras para proporcionar zonas virtualmente sujetas y zonas virtualmente no sujetadas de las mismas, dichas zonas virtualmente no sujetadas proporcionan una pluralidad de regiones de bolsas; un material de alta absorbencia localizado dentro de cada una de las regiones de bolsa para proporcionar un laminado absorbente; y fibras de matriz por aire dispersadas dentro del material de alta absorbencia en dichas regiones de bolsa, dichas fibras de matriz están presentes en una cantidad promedio la cual es de 0,1 - 10% por peso. En particular la presente invención se refiere a artículos absorbentes, particularmente a productos absorbentes para el cuidado personal, más particularmente a prendas desechables las cuales incluyen bolsas discretas de un material de polímero superabsorbente mantenido entre un par de hojas portadoras.
Patent UY-24360-A1 (UY)
Title: Sistema de estructuracion interna de establecimientos para la comercializacion de servicios de telecomunicacion.
Inventor: ANTONIO CANTON GONGORA
IPC: A47F10/00
Filed: 1996-10-31
Abstract: Sistema de estructuración interna de establecimientos para la comercialización de servicios de telecomunicación que consiste en un conjunto de elementos que configuran un establecimiento comercial en el que se contempla la suseción repetitiva de una pluralidad de pòrticos idénticos, que estructuran el espacio útil del local, estando constituídos los pórticos por columnas y vigas luminarias soportadas por las columnas a las que se incorporan módulos diferentes que estructuran una división de áreas a modos de atención al cliente, identificándose un escaparate, una zona de presentación de servicioos, zona de promoción o enfatización de los servicios, una zona o área de atención personalizada al cliente y un área de exhibición de equipos disponibles.