Patent SG-11201810765P-A (SG)
Title: Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
Inventor: VERDIN ERIC
IPC: G02B1/08
Filed: 2017-06-02
Abstract: CBHB Q.41 millimoles 04. C6-BHB 0.21 C8-BHB 0.35 rniiiirnoles C8-BHB 0.18 millimales BHB 025 miltimoles 4- Fasting (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT 0111111010 0111 inn Holm nacnum (10) International Publication Number WO 2017/213999 Al (51) International Patent Classification: G02F 1/1368 (2006.01) G02F 1/13363 (2006.01) G02B 1/08 (2006.01) G02F 1/1335 (2006.01) G02B 5/30 (2006.01) (21) International Application Number: PCT/US2017/035826 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/346,975 07 June 2016 (07.06.2016) US (71) Applicants: THE J. DAVID GLADSTONE INSTI- TUTES [US/US]; 1650 Owens Street, San Francis- co, California 94158 (US). THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor, Oakland, California 94607 (US). ITHACA COLLEGE [US/US]; 953 Danby Road, Ithaca, New York 14850 (US). (72) Inventors: VERDIN, Eric; 141 Tamalpais Avenue, Mill Valley, California 94941 (US). ULRICH, Scott; 649 Val- ley Rd., Brooktondate, New York 14817 (US). NEWMAN, John; 545 Burnett Ave., Apt 102, San Francisco, California 94131 (US). (74) Agent: RUBIN, Michael B.; Bozicevic, Field & Francis LLP, 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (54) Title: MEDIUM CHAIN FATTY ACID ESTERS OF BETA-HYDROXYBUTYRATE AND BUTANEDIOL AND COM- POSITIONS AND METHODS FOR USING SAME BHB vs BHB-esters alter injection Figure 6c (57) : Aspects of the present disclosure include fatty acid [3-hydroxyester compounds (e.g., fatty acid esters of (3-hydroxybu- tyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid [3-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described. [Continued on next page] WO 2017/213999 Al MIDEDIMOMOIMIRMEM0011010CMCHIMINHOIS SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))