Patent SG-11201808911S-A (SG)
Title: Trispecific and/or trivalent binding proteins
Inventor: NABEL GARY
IPC: C07K16/32
Filed: 2017-04-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 010111010 III 011101E110111011111111111 01111E10 1111 00 1111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/180913 A3 19 October 2017 (19.10.2017) WIPO I PCT (51) International Patent Classification: Edward; c/o Sanofi, 55 Corporate Drive, Mail Code C07K 16/24 (2006.01) C07K 16/32 (2006.01) 55A-505A, Bridgewater, NJ 08807 (US). WEI, Ronnie; C07K 16/28 (2006.01) A61P 35/00 (2006.01) c/o Sanofi, 55 Corporate Drive, Mail Code 55A-505A, (21) International Application Number: Bridgewater, NJ 08807 (US). BENINGA, Jochen; c/o PCT/US2017/027488 Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt Am Main (DE). RAO, Ercole; c/o Sanofi-Aventis Deutschland (22) International Filing Date: GmbH, 65926 Frankfurt Am Main (DE). LEUSCHNER, 13 April 2017 (13.04.2017) Wulf Dirk; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt Am Main (DE). BELL, Christian; c/o Sanofi- (25) Filing Language: English Aventis Deutschland GmbH, 65926 Frankfurt Am Main (26) Publication Language: English (DE). LANGE, Christian; c/o Sanofi-Aventis Deutsch- land GmbH, 65926 Frankfurt Am Main (DE). CORVEY, (30) Priority Data: Carsten; c/o Sanofi-Aventis Deutschland GmbH, 65926 62/322,036 13 April 2016 (13.04.2016) US Frankfurt Am Main (DE). 62/331,191 03 May 2016 (03.05.2016) US 62/412,187 24 October 2016 (24.10.2016) US (74) Agent: JONES, Kevin et al.; Morrison & Foerster LLP, EP17305298.6 17 March 2017 (17.03.2017) EP 425 Market Street, San Francisco, CA 94105-2482 (US). (71) Applicant: SANOFI [FR/FR]; 54, Rue la Boetie, 75008 (81) Designated States (unless otherwise indicated, for every Paris (FR). kind of national protection available): AE, AG, AL, AM, (72) Inventor; and AO, CA, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, Applicant (for US only): YANG, Zhi-Yong [US/US]; c/o DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, (71) = = Sanofi, 55 Corporate Drive, Mail Code 55A-505A, Bridge HR, water, NJ 08807 (US). KW, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = — Inventors: NABEL, Gary, J.; c/o Sanofi, 55 Corpo- MK, (72) MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, rate Drive, Mail Code 55A-505A, Bridgewater, NJ 08807 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (US). WU, Lan; c/o Sanofi, 55 Corporate Drive, Mail SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, — Code 55A-505A, Bridgewater, NJ 08807 (US). SEUNG, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS = FIG. 1 A = = = P , , . CODV — = = = = = cr) .4 Knob-in-Ho e M ,-1 cn © (57) : The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three GC antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein 1-1 ----- possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein IN ,—I possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and 0 uses of such binding proteins. ei O [Continued on next page] WO 2017/180913 A3 MUNRO DOI 0101g010111311110 1101HOMMEMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 08 February 2018 (08.02.2018) (48) Date of publication of this corrected version: 23 November 2017 (23.11.2017) (15) Information about Correction: see Notice of 23 November 2017 (23.11.2017)