baber/WOPTO huggingface dataset:
Patent CA-3064322-A1 (CA)
Title: Recombinant measles virus expressing zika virus proteins and their applications
Inventor: TANGY FREDERIC
IPC: A61K39/00
Filed: 2018-06-06
Abstract: The present invention relates to recombinant measles virus expressing Zika virus proteins and their applications, in particular in inducing preventive protection against Zika virus. The present invention is directed to recombinant measles virus (MV) expressing at least (i) the precursor of membrane (prM) protein of a Zika virus (ZIKV), and the envelope (E) protein of a ZIKV or a truncated version thereof, or (ii) the E protein of a ZIKVor a truncated version thereof, and concerns recombinant infectious particles of said MV-ZIKV able to replicate in a host after an administration, and also Virus Like Particles (VLPs) that contain these ZIKV proteins at their surface. The present invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce these recombinant infectious particles and VLPs. The present invention also relates to the use of these recombinant infectious particles and/ or VLPs, in particular under the form of a composition, more particularly in a vaccine formulation, for the prevention of an infection by ZIKV or for the preventive protection against clinical outcomes of ZIKV infection.
Patent CA-3066758-A1 (CA)
Inventor: WATANABE MASAO
IPC: B25B23/04
Filed: 2020-01-07
Abstract: According to one implementation, a tool feeding mechanism for a handheld tool rotating device, having a holder and a first air motor, includes a coupler, a fixing member, a moving mechanism and a second air motor. The holder chucks and holds a rotating tool. The first air motor rotates the holder.  The tool feeding mechanism is attached to the tool rotating device. The coupler is attached to the tool rotating device. The fixing member is attached directly or indirectly to a workpiece of hole processing using the rotating tool.  The moving mechanism moves the coupler relatively to the fixing member in a tool axis direction. The second air motor powers the moving mechanism.
Patent CA-3067138-A1 (CA)
Inventor: MANGA JOSEPH
IPC: B05B1/18
Filed: 2020-01-09
Abstract: A handshower assembly includes a docking station with a first portion and a removable second portion. The docking station is configured to mount to a grab bar of a tub or shower and move relative to the grab bar for a user to position a handshower as desired.
Patent CA-3068942-A1 (CA)
Inventor: HOJER SVANTE
IPC: A61B5/097
Filed: 2018-07-04
Abstract: The disclosure pertains to a system 100 and method for collecting and measuring particles in exhaled air. The system 100 is arranged to allow for examination of the full or substantially the full volume of each exhalation of a subject.
Patent CA-3070347-A1 (CA)
Title: Electrolyte composition, electrolyte film, and battery
Inventor: KANAMURA KIYOSHI
IPC: H01M10/056
Filed: 2018-07-24
Abstract: [Problem] To provide: an electrolyte film having a practical film thickness, an excellent mechanical strength, and electrochemical characteristics; an electrolyte composition making it possible to obtain the electrolyte film; and a cell in which the electrolyte film is used. [Solution] An electrolyte composition characterized in comprising an electrolyte powder, a binder, and an ion-conductive material; the electrolyte powder being an oxide-based ceramic electrolyte powder; the binder being a polymer compound that is stable with respect to metal ions; the ion-conductive material being a solvated ion-conductive material or an ion-conductive solution having a metal ion-based compound. An electrolyte film characterized in being provided with an electrolyte powder and a composite material in which a binder and an ion-conductive material are made into a composite.
Patent CA-3073052-A1 (CA)
Title: Method for calibrating the performance range of a pneumatically sealed trocar
Inventor: VARNER KENNETH
IPC: A61B17/00
Filed: 2018-09-04
Abstract: A method and assembly for calibrating the pneumatic performance range of a system for delivering pneumatic power to a trocar, which includes the steps of: supplying pneumatic power to a trocar to achieve a desired cavity pressure; measuring the pneumatic power and cavity pressure over a time period, as the system attempts to maintain the desired cavity pressure; calculating performance characteristics of the trocar based on the measured cavity pressure and pneumatic power values; and adjusting the pneumatic power supplied to the trocar based upon the performance characteristics of the trocar.
Patent CA-3073073-A1 (CA)
Title: Diagnostic and therapeutic methods for cancer
Inventor: KLIJN CHRISTIAAN NICOLAAS
IPC: C12Q1/6886
Filed: 2018-09-07
Abstract: The present invention provides diagnostic and therapeutic methods and compositions for cancer. The invention provides methods of determining whether an individual having a cancer is likely to respond to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of predicting responsiveness of an individual having a cancer to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of selecting a therapy for an individual having a cancer, and methods of treating an individual having cancer based on the presence of a biomarker of the invention (e.g., a KRAS activating mutation, e.g., a KRAS-G13D mutation, or an NRAS activating mutation).
Patent CA-3077606-A1 (CA)
Title: Polytherapie pour la prevention d'une addiction
Inventor: BLACKBURN BRENT
IPC: A61K31/4418
Filed: 2018-10-15
Abstract: La présente invention concerne une nouvelle polythérapie pour réduire ou prévenir l'acquisition d'une réponse conditionnée chez un mammifère, comprenant l'administration au mammifère d'une quantité thérapeutiquement efficace d'un composé inhibiteur d'aldéhyde déshydrogénase (ALDH-2), tel qu'un composé de formule (I), en combinaison avec une substance qui produit la réponse conditionnée, telle qu'un médicament contenant un agent de production de dopamine tel qu'un opioïde, de sorte que la combinaison agisse de façon à réduire ou prévenir l'acquisition d'une réponse conditionnée, et l'effet secondaire délétère de l'usage abusif, la dépendance, l'abus et/ou la dépendance.
Patent CA-3078960-A1 (CA)
Title: Methods for treating hepatitis b infection
Inventor: KOSER MARTIN
IPC: A61K31/7105
Filed: 2018-10-19
Abstract: The disclosure relate to improved oligonucleotide-based compositions and related methods for treating HBV infection in a subject. In some embodiments, the disclosure relates to the development of potent oligonucleotides that produce durable knockdown of HBV surface antigen (HBsAg) expression. The oligonucleotide induce RNA interference (RNAi)-mediated recognition and destruction of mRNA which encodes all forms of HBsAg in hepatocytes. The present disclosure provides oligonucleotides for reducing expression of hepatitis B virus surface antigen (HBsAg) mRNA, the oligonucleotide comprising an antisense strand. In some embodiments, the oligonucleotide further comprises a sense strand, wherein the sense strand forms a duplex region with the antisense strand.
Patent CA-3081586-A1 (CA)
Inventor: LIVENGOOD JILL A
IPC: A61K39/12
Filed: 2018-11-05
Abstract: The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
Patent CA-3082037-A1 (CA)
Inventor: SULCHEK TODD
IPC: B01L3/00
Filed: 2017-11-08
Abstract: Des modes de réalisation de la présente invention peuvent comprendre un procédé d'administration intracellulaire par convection consistant: à fournir des cellules et des molécules à un microcanal ayant des surfaces de compression, les surfaces de compression définissant des espaces de compression ayant une hauteur de 20 à 80 % du diamètre de cellule moyen; une pluralité d'espaces de relaxation disposés entre les surfaces de compression; à faire circuler le milieu cellulaire à travers le microcanal, le milieu cellulaire s'écoulant à travers le microcanal. La pluralité de cellules subissent un processus d'administration intracellulaire par convection consistant: à comprimer la pluralité de cellules, la compression amenant la pluralité de cellules à subir une perte de volume intracellulaire (Vperte); à faire passer la pluralité de cellules dans un premier espace de relaxation, la pluralité de cellules subissant un gain en volume (Vgain) et à absorber une partie de la pluralité de molécules.
Patent CA-3083824-A1 (CA)
Inventor: MIETHING WERNER
IPC: B60R1/00
Filed: 2018-11-27
Abstract: The invention relates to a camera arm (100) of a camera-based mirror substitute system for a motor vehicle, the arm having a first structural element (110) for connecting the camera arm (100) to a motor vehicle and a second structural element (120) which has at least one camera (180). In order to provide a fixation system for cameras of camera-monitor systems acting as mirror substitutes in motor vehicles, which offers improved protection against external damage to the fixation or the camera arm and to all elements, devices and modules located thereon, in particular to cameras, and which allows the camera to have an optimal image range, according to the invention the camera arm (100) has, in addition, a volume-variable fluid container (150) which connects the first structural element (110) and the second structural element (120) and at least one restoring element (155) which connects the first structural element (110) and the second structural element (120) and draws the second structural element (120) towards the first structural element (110), such that the second structural element (120) can be moved relative to the first structural element (110) by varying the quantity of fluid in the fluid container (150).
Patent CA-3086648-A1 (CA)
Title: Container weighing system method and apparatus
Inventor: DOKKEN JOEL
IPC: G01G19/22
Filed: 2020-07-13
Abstract: A mobile apparatus for carrying and weighing a load includes a mobile frame supported by a plurality of wheels. At least one container is supported on the mobile frame for carrying a load. A plurality of sensor assemblies are coupled between the frame and the container, the sensor assemblies resistive to a weight force exerted by the container towards the frame in a generally vertical sensing direction for sensing a weight of the load, and the sensor assemblies non-resistive to error forces exerted generally orthogonally to the sensing direction for filtering out the error forces from the sensed weight. A stabilizing assembly is coupled between the container and the frame, the stabilizing assembly freely accommodating transfer of the force exerted by the container towards the frame in the sensing direction, and simultaneously inhibiting shifting of the container relative to the frame in one or more shifting directions perpendicular to the sensing direction.
Patent CA-3090982-A1 (CA)
Inventor: SEUSS JOHN
IPC: H02H7/26
Filed: 2018-12-19
Abstract: Methods and systems are provided for automatically coordinating protection settings for relays within an electrical power distribution network. A method includes using a graph traversal mechanism to analyze geographical-based equipment data that contains information about overcurrent relays within the electrical power distribution network. A customizable rule base is applied to protection guidelines. Protection settings are determined based upon the applied customizable rule base and the direction of fault current flow from each source. The determined protection settings are used for the overcurrent relays to control switches in the electrical power distribution network in response to a detected fault.
Patent CA-3094158-A1 (CA)
Title: Article de fermeture a element de fixation auxiliaire
Inventor: MILBRANDT JAY
IPC: B65D33/16
Filed: 2019-03-19
Abstract: Selon un aspect, un article (20) est conçu pour fermer un premier produit (104) et se fixer à un second produit (106). L'article (20) comprend une étiquette (22) et un élément de fixation (24). L'étiquette (22) présente un périmètre. L'étiquette (22) comprend une ouverture (52) et une première découpe (50) reliant l'ouverture (52) et le périmètre.. L'ouverture (52) et la première découpe (50) sont conçues pour accepter une partie du premier produit (104). L'élément de fixation (24) est relié à l'étiquette au niveau d'un élément de jonction (26), l'élément de fixation (24) étant conçu pour se fixer au second produit (106).
Patent CA-3095352-A1 (CA)
Title: Composition for treating parasites infestations
Inventor: GUIMBERTEAU FLORENCE
IPC: A01N43/90
Filed: 2018-11-23
Abstract: The present invention relates to a veterinary or pharmaceutical composition comprising: (i) about 1-65 % w/v of a pyrethroid, or a salt thereof, (ii) a macrocyclic lactone, or a salt thereof, (iii) at least one alkalizing agent, (iv) at least one non aqueous solvent, wherein the pH of the composition is comprised between about 6.5 and 8.5, when measured by adding 25% of water to an aliquot of said composition. The invention further relates to the use of such composition for preventing and/or treating parasites infestations.
Patent CA-3096135-A1 (CA)
Title: Outil a main comportant une piece d'outil telescopique
Inventor: LI YUEMING
IPC: B25B7/06
Filed: 2018-04-09
Abstract: L'invention concerne un outil à main comportant une pièce d'outil télescopique, comprenant une poignée et un élément de liaison. La poignée comprend une partie poignée (1) et une partie poignée (2) ; l'élément de liaison comprend une extrémité d'outil (31) et une extrémité de poignée (32) ; la pièce d'outil est conçue pour être entraînée par les poignées et l'élément de liaison et peut se déplacer de manière télescopique entre un état de fonctionnement et un état rétracté par rapport aux poignées ; et dans l'état de fonctionnement, la pièce d'outil s'étend hors des extrémités proximales (11, 21) des poignées, et dans l'état plié, la pièce d'outil est rétractée dans les poignées et située entre les extrémités proximales (11, 21) et les extrémités distales (21, 22) des poignées.
Patent CA-3100663-A1 (CA)
Inventor: PETERSON STEPHANIE
IPC: G06F16/31
Filed: 2019-05-09
Abstract: A method and apparatus for managing and integrating lead sources for a marketing/advertisement campaign on a platform that allocates and optimizes lead source budgets and provides a customer service and payment processing function. The present technology as disclosed and claimed herein provides a platform that is a customer retention and customer management system that is automated to provide lead estimations and optimizations to allocate and optimize lead source budgets where the system has a learning function that improves over time.
Patent CA-3101181-A1 (CA)
Inventor: SMITH SEAN WESLEY
IPC: C07D401/14
Filed: 2019-05-24
Abstract: Amino-pyrazinecarboxamide compounds of formula (I), conjugates, and pharmaceutical compositions for use in the treatment of disease such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGFpR2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
Patent CA-3101315-A1 (CA)
Title: Plaque de friction humide et dispositif d'embrayage a disques multiples humides pourvu d'une plaque de friction humide
Inventor: UEHARA KAZUYA
IPC: F16D13/74
Filed: 2019-05-24
Abstract: L'invention concerne une plaque de friction humide qui est capable d'améliorer les performances de décharge d'une huile de lubrification adhérant à la surface d'un élément de friction, et un dispositif d'embrayage à disques multiples humides pourvu de la plaque de friction humide. Une plaque de friction humide (200) est configurée en étant pourvue de rainures à huile (203) et d'éléments de friction (210) sur un métal de cur annulaire en forme de plaque plate (201). Les éléments de friction (210) possèdent chacun une surface de glissement de friction (213) et des évidements à huile de lubrification (214) formés sur la surface d'une couche poreuse (211). Une pluralité d'évidements à huile de lubrification (214) sont formés sur une surface continuellement lisse n'ayant aucune portion acérée de formes pointues telles que des coins, et sont en retrait par rapport à la surface de glissement de friction (213). La couche poreuse (211) possède des cavités (212) formées dans une zone constituant la surface de glissement de friction (213) et dans une zone constituant les évidements à huile de lubrification (214), les vitesses de formation dans les deux zones étant identiques.
Patent CA-3103692-A1 (CA)
Inventor: VAN GANSEN MATHIEU DANIEL MARIE
IPC: F01D17/10
Filed: 2019-07-02
Abstract: A turbomachine for an aircraft extending axially along an axis X comprising a primary flow path in which an air stream flows intended for the combustion chamber (102) and a secondary flow path in which an air stream flows intended for propulsion, the compressor (101) comprising a plurality of first variable bypass valves (1A), a plurality of second variable bypass valves (1B), the turbomachine comprising a first control system (2A) configured to control the movement of the plurality of first variable bypass valves (1A) and a second control system (2B) configured to control the movement of the plurality of second variable bypass valves (1B), the first control system (2A) and the second control system (2B) being separate.
Patent CA-3104728-A1 (CA)
Title: A led lighted beauty fridge with a mirror
Inventor: ZHIHAO YAO
IPC: A47G1/02
Filed: 2020-12-31
Abstract: The present utility model is related to the technical field of skincare, in particular, it refers to a LED lighted beauty fridge with a mirror, which can store skincare products and also increase the convenience of the customer; it includes the fridge body and its respective door, the fridge door has a pivot hinge on the front which connects to the body of the fridge, the fridge door has a mirror and a control circuit, the mirror is embedded with LED light strips; the mirror has a touch switch button, and the LED light strips are electrically connected to the touch switch button through the control circuit.
Patent CA-3106860-A1 (CA)
Title: Composes de 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol et de 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol et leur utilisation therapeutique
Inventor: PATEL LISA
IPC: A61P35/00
Filed: 2019-08-15
Abstract: La présente divulgation s'applique de manière générale au domaine des composés thérapeutiques, y compris les composés correspondant à la formule suivante : Plus précisément, la présente divulgation concerne certains composés de 1-méthyl-4-[(4-phénylphenyl)sulfonylméthyl]cyclohexanol et de 1-méthyl-4-[[4-(2-pyridyl)phényl] sulfonylméthyl]cyclohexanol substitués (ci-après désignés collectivement en tant que composés de CHMSA) qui sont utiles, par exemple, pour le traitement de troubles (c.-à-d. maladies) comprenant, par exemple, le myélome multiple, le lymphome diffus à grandes cellules B, la leucémie myéloblastique aiguë, la leucémie à éosinophiles, le glioblastome multiforme, le mélanome, le cancer des ovaires, le cancer résistant à la chimiothérapie, le cancer résistant aux traitements par rayonnement, la polyarthrite inflammatoire, la polyarthrite rhumatoïde, la polyarthrite psoriasique, le psoriasis, la colite ulcéreuse, la maladie de Crohn, le lupus érythémateux disséminé, la néphropathie lupique, l'asthme, la bronchopneumopathie chronique obstructive, la stéatose hépatique non alcoolique, la stéatohépatite non alcoolique, l'hépatite chronique active auto-immune, l'hidrosadénite suppurée, etc. La présente invention concerne également des compositions pharmaceutiques comprenant ces composés, et l'utilisation de ces composés et compositions, par exemple, dans le cadre de thérapies.
Patent CA-3109037-A1 (CA)
Title: Methods and systems for cache optimization
Inventor: LINTZ CHRISTOPHER
IPC: H04N21/231
Filed: 2021-02-12
Abstract: Methods and systems for cache optimization are described. Content items served to client devices of a content distribution network may be associated with a cache value. The cache value for a content item may cause a cache device to cache the content item for a period of time. The cache value for the content item may be updated based on increasing or decreasing popularity. The content item may be encoded at a plurality of bitrates, and cache values may vary across the plurality of bitrates such that multiple copies of the content item may each be cached for varying periods of time depending on a corresponding bitrate.
Patent CA-3110622-A1 (CA)
Inventor: YASUOKA TOMOMICHI
IPC: B23K26/064
Filed: 2019-09-04
Abstract: L'invention concerne un procédé de soudage comprenant une étape consistant à irradier une pièce à travailler avec un faisceau laser tout en déplaçant le faisceau laser et la pièce à travailler l'un par rapport à l'autre, et à balayer le faisceau laser sur la pièce à travailler tout en faisant fondre et en soudant la partie irradiée de la pièce à travailler. Le faisceau laser est constitué d'une région de puissance principale et d'une région de puissance secondaire qui est au moins partiellement sur le côté direction de balayage de la région de puissance principale. La densité de puissance de la région de puissance principale est égale ou supérieure à la densité de puissance de la région de puissance secondaire, et est une densité de puissance qui est au moins apte à générer des trous de serrure.
Patent CA-3112325-A1 (CA)
Inventor: MCDANIEL MAX P
IPC: B01J20/06
Filed: 2019-09-25
Abstract: Disclosed herein are methods for preparing fluorided solid oxides by contacting an acidic fluorine-containing compound with an inorganic base to form an aqueous mixture having a pH of at least 4, followed by contacting a solid oxide with the aqueous mixture to produce the fluorided solid oxide. Also disclosed are methods for preparing fluorided solid oxides by contacting an acidic fluorine-containing compound with a solid oxide to produce a mixture, followed by contacting the mixture with a inorganic base to produce the fluorided solid oxide at a pH of at least about 4. The fluorided solid oxide can be used as an activator component in a catalyst system for the polymerization of olefins.
Patent CA-3113667-A1 (CA)
Inventor: FATHEREE PAUL R
IPC: A61P27/02
Filed: 2019-10-18
Abstract: The invention provides a compound of formula 1 or a pharmaceutically-acceptable salt thereof, that is useful as a JAK inhibitor. The invention also provides pharmaceutical compositions comprising the compound, methods of using the compound to treat diseases amenable to a JAK inhibitor, and processes useful for preparing the compound.
Patent CA-3115390-A1 (CA)
Title: Procede et dispositif de communication sans fil
Inventor: XU YANG
IPC: H04W28/06
Filed: 2018-10-15
Abstract: Les modes de réalisation de la présente invention concernent un procédé et un dispositif de communication sans fil, qui peuvent faire la distinction entre des clés secrètes utilisées pour des paquets de données de sorte qu'une extrémité réceptrice et une extrémité transmettant des paquets de données utilisent la même clé secrète pour traiter le même paquet de données. Ledit procédé comprend : au moyen d'une première pile de protocoles, le traitement d'un premier paquet de données transmis, à l'aide d'une première clé secrète; et au moyen d'une seconde pile de protocoles, le traitement d'un second paquet de données transmis, à l'aide d'une seconde clé secrète, la première pile de protocoles et la seconde pile de protocoles partageant au moins une couche de protocole.