baber/WOPTO huggingface dataset:
Patent CR-20170109-A (CR)
Title: Diacuerpos monovalentes biespecificos que son capaces de unir cd19 y cd3, y usos de los mismos
Inventor: LAM CHIA-YING KAO
IPC: C07K16/28
Filed: 2015-09-22
Abstract: Los diacuerpos monovalentes bi-específicos CD19 x CD3, y particularmente, anticuerpos Fc monovalentes bi-específicos CD19 x CD3, son capaces de unirse simultáneamente a CD19 y CD3, y se utilizan en el tratamiento de neoplasias hematológicas.
Patent CR-20170195-A (CR)
Title: Espiro-tiazolonas
Inventor: FASCHING BERNHARD
IPC: C07D491/20
Filed: 2015-11-11
Abstract: La presente invención proporciona espiro-tiazolonas, que actúan como moduladores del receptor V1a, y en particular, como antagonistas del receptor V1a, su fabricación, a composiciones farmacéuticas que los contienen y a su uso como medicamentos. Los presentes compuestos son útiles como agentes terapéuticos que actúan de manera periférica y central en condiciones de secreción inadecuada de vasopresina, ansiedad, trastornos depresivos, trastorno obsesivo-compulsivo, trastornos del espectro autista, esquizofrenia, comportamiento agresivo y trastornos del sueño por cambio de fase, en particular, descompensación horaria.
Patent CR-20170316-A (CR)
Title: Compuestos de pirazina para el tratamiento de enfermedades infecciosas
Inventor: YAN SHIXIANG
IPC: C07D487/04
Filed: 2016-01-13
Abstract: La presente invención se refiere a compuestos de la fórmula (I), o sales, un enantiómero o diastereómero farmacéuticamente aceptables de los mismos, en la que R1 a R4 son como se ha descrito anteriormente. Los compuestos pueden ser útiles para el tratamiento o profilaxis de la infección por el virus de la hepatitis B.
Patent CR-20190040-A (CR)
Title: Sustituciones nucleotídicas predeterminadas
Inventor: THOMSEN HANNE CECILIE
IPC: C12N15/10
Filed: 2017-06-23
Abstract: En los enfoques de mejoramiento de plantas tradicionales, puede utilizarse mutagénesis química para introducir sustituciones nucleotídicas aleatoriamente en el genoma de una planta, es decir sin posibilidades de controlar los sitios de los cambios nucleotídicos. A causa de las complejidades genómicas, la probabilidad estadística es extremadamente baja en cuanto a hallar una sustitución nucleotídica predeterminada. La presente invención, sin embargo, demuestra cómo se desarrolla un uso novedoso, alternativo, de la reacción en cadena de polimerasa digital (dPCR), preferiblemente dPCR en gotas (ddPCR), para explotar el hallazgo de sustituciones nucleotídicas específicas en genes mutados. La plataforma completa comprende un método de relevamiento con una biblioteca de organismos mutagenizados, sistemas basados en PCR digital y una configuración para propagar y analizar organismos mutados identificados.
Patent EC-SP014124-A (EC)
Title: Proceso para elaboracion de asfaltos a partir de desechos de petroleo
Inventor: ARIAS BASANTES MANUEL RAMON
IPC: C01B33/06
Filed: 2001-07-24
Abstract: Los desechos de petróleo no pueden ser utilizados directamente como materia prima para elaborar asfaltos debido a que sus características físicas y químicas no posibilitan este proceso. La tecnología objeto de está invención acondiciona las características del petróleo de desecho por medio de procesos físico-químicos para convertirlo en asfalto de buena calidad. Esta tecnología también puede ser utilizada como matriz para deposición de residuos de procesos industriales. Los productos utilizados en el proceso de acondicionamiento son una mezcla de minerales naturales que actúan sinergéticamente con el objeto de inmovilizar los componentes tóxicos contenidos en el petróleo de desecho e incrementar la adhesión y cohesión del asfalto final. Los procesos físico-químicos que tienen lugar durante el acondicionamiento son la adsorción selectiva, el intercambio iónico, la formación de grupos funcionales de superficie y el desparafinado.
Patent EC-SP066797-A (EC)
Title: Procedimientos para la preparacion de halogenuros de aril- y heteroarilalquilsulfonilo
Inventor: GHOSH MOUSUMI
IPC: C07C303/20
Filed: 2006-08-25
Abstract: La presente invención provee procedimientos de preparación de halogenuros de arilalquilsulfonilo y halogenuros de heteroarilalquilsulfonilo de la fórmula Ar-R-SO2-X, que son útiles como intermediarios en la preparación de agentes farmacéuticos.
Patent EC-SP078004-A (EC)
Title: PREPARACIÓN y USO DE COMPUESTOS COMO INHIBIDORES DE PROTEASAS
Inventor: ZHU ZHAONING
IPC: A61K31/519
Filed: 2007-12-12
Abstract: Se revelan los compuestos de la fórmula I Io un estereoisómero, tautómero o sal o solvato del mismo aceptable para uso farmacéutico, donde Q es un enlace o -N(R5)-;T es un enlace , -O-, -C(O)-, S, -N(R5)- o -C(R6'R7');U es un enlace o -C(R6)(R7)-; Y es C o N;Z es C o N;el anillo A, que incluye las variables Y y Z, es un anillo cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilarilo y heteroarilo de tres a nueve miembros que tiene 0 a 4, con preferencia 0 a 2, heteroátomos seleccionados independientemente del grupo que consiste en O, S, N y -N(R)-, donde el anillo A está no sustituido o sustituido con 1 a 5 residuos R1 seleccionados independientemente y/u oxo cuando el anillo A es cicloalquilo, cicloalquenilo, heterociclilo o heterociclenilo;	 y R, R1, R2, R3, R4, R5, R6, R6, R7 y R7' son tal como se definen en la memoria descriptiva; composiciones farmacéuticas que comprenden los compuestos de la fórmula I y el método para inhibir aspartil proteasas y, en particular, los métodos para tratar enfermedades cardiovasculares, enfermedades cognitivas y neurodegenerativas .
Patent EC-SP972147-A (EC)
Title: Metodo y aparato para producir un carton corrugado de multiples capas
Inventor: KIM DO WOOK
IPC: B31F1/20
Filed: 1997-06-16
Abstract: Un mejoramiento en el método y aparato para producir cartones corrugados de múltiples capas por laminación ordenada de medios corrugados de múltiples capas entre lineados superiores e inferiores de un cartón corrugado de múltiples capas y con ello haciendo más delgado el cartón y mejorando la resistencia compresiva del mismo para reducir sustancialmente el volumen del paquete. El cartón corrugado de múltiples capas producido por medio de este método y por el aparato de esta invención, efectivamente resiste a los golpes externos aplicados al paquete, protegiendo asi los artículos empacados.
Patent EC-SP993102-A (EC)
Title: Composiciones farmaceuticas
Inventor: HADVARY PAUL
IPC: A61K31/35
Filed: 1999-08-13
Abstract: Composición farmacéutica de administración oral que contiene un inhibidor de lipasas gastrointestinales, uno (o más) compuesto (s) adicional (es) del grupo consistente en quitosán, sus derivados y sales de los mismos, y exipientes auxiliares.
Patent FI-20001702-A (FI)
Inventor: HALME MATTI
IPC: H04L12/24
Filed: 2000-07-24
Abstract: The invention relates to methods for controlling of transmission of data in IP networks. According to the invention, the sequence numbers and sending times of transmitted IPSec packets are stored, acknowledgement is sent for every N:th received IPSec packet or after any IPSec packet if T seconds have elapsed after sending a previous acknowledgement packet, the acknowledgement comprising the sequence number of the particular IPSec packet after the reception of which the acknowledgement is sent and the counter values indicating the number of packets and bytes received, and at least the round trip time, packet success rate and throughput value are determined from the reception time of the acknowledgement and the stored sending time associated with the sequence number in the acknowledgement and the counter values indicating the number of packets and bytes received.
Patent FI-20002715-A (FI)
Inventor: LOCK CHRISTOPHER COLIN
IPC: H04R7/04
Filed: 2000-12-11
Abstract: A flat panel rectangular or elliptical loudspeaker has one or more anisotropic diaphragms 14, 15, made of double skinned fluted polypropylene copolymer (core flute) or corrugated cardboards having a longitudinal bending strength greater than the transverse bending strength. The diaphragm is vibrated by a driver unit 16 which comprises a magnet 17 and voice coil 18. In this version the magnet 17 is mounted on the rear diaphragm 15 and the voice coil 18 is mounted on the front diaphragm 14. The two diaphragms 14, 15 are mounted at their edges to a frame 11 with the driver unit 16 mounted in the space enclosed by the frame and the diaphragms.
Patent FI-20050768-A (FI)
Inventor: PLANMAN TUOMAS
IPC: A61B5/00
Filed: 2005-07-19
Abstract: The present invention relates to a health monitoring device for measuring blood or tissue indicators and a strip cassette. The device comprises a body having first and second openings, a piercing means being connected to the body and having a piercing head, the piercing means being arranged to extend from the first opening and cockable and releasable for piercing the skin with the piercing head, and a space into which a number of sensor strips can be arranged so that the strips can be brought out from the body one at a time. The device further comprises a shutter that is functionally connected to the body and has a first position arranged to tightly close the first and second openings, and a second position for allowing one sensor strip to be pushed from the first opening into sampling position and for exposing the first and second openings.
Patent FR-1603312-A (FR)
Title: Injectable vaccine prepns
IPC: A61K9/113
Filed: 1964-10-23
Granted: 1971-04-05
Abstract: Method for prepn. of vaccines (I). A multiple emulsion is prepared in which an aqueous medium containing the antigen(s), is dispersed in an oil (e.g. Drakeol 6VR, Bayol F, or Arachis) with the aid of an emulsifying agent (5-15% Arlacel A), the particle size being 1-7 mu. This is then dispersed in a second aqueous phase, the ratio (oil:water) being between 3:1 and 1:10, by the use of a suitable emulsifying agent (e.g.Tween 80), and a homogeniser, or ultra-sonic vibration (18000-20000 Hz). The size of the oil particles is 10-50 mu. A more stable emulsion is produced by the addition of 1% agar. Any type of antigen may be used, including influenza virus, Newcastle disease virus, tetanus toxoid, polio virus, Bordetella pertussis bacteria, measles virus, and diptheria toxoid. (1) Low viscosity (2) I is rapidly transported through the body (3) Multiple dose containers can be used.
Patent GB-1050437-A (GB)
IPC: H01P1/26
Abstract: 1,050,437. Waveguide attenuators. ASSOCIATED ELECTRICAL INDUSTRIES Ltd. Oct. 4, 1963 [Oct. 19. 1962], No. 39703/62. Heading H1W. A waveguide attenuator comprises a dissipative member, e.g. a water conduit 3, rigidly secured at one end to an end wall 2 of the waveguide and extending at the other end through a longitudinal wall of the waveguide on to a support slidable upon the wall. The sliding of the support allows thermal expansion of the dissipative member. As shown, the support consists of two parts 9, 10 which when drawn together by screws 11 clamp the end of tube 5 within an 0-ring 12. A hollow space 15 within the part 9 communicates with a water inlet or outlet. Transverse movement of the sliding member is prevented by the sides of a U-shaped housing 18 secured to the side walls of the waveguide.
Patent GB-1051429-A (GB)
IPC: B21D15/06
Abstract: 1,051,429. Corrugating. PHELPS DODGE COPPER PRODUCTS CORPORATION. Oct. 19, 1964 [Oct. 30, 1963], No. 42483/64. Heading B3E. A method of corrugating a tube comprises the steps of pressing the tube periphery radially inwardly simultaneously at a series of pressing locations spaced lengthwise along the tube and to depths which progressively increase from a first to a last location of the series, advancing the tube at constant speed lengthwise during the multiple pressings and rotating the pressing locations as a unit at a constant speed around the advancing tube while maintaining the pressing locations in positions to press successive turns simultaneously. As shown, a tube 11 is advanced at constant speed through a first rotary pressing head comprising five helically grooved rollers 12 equally spaced about the tube axis. The roller axles 14 are journalled in plates 9, 9a which are rotated by means of a motor-driven pulley 5. The tube corrugated at 11a then passes through a second pressing head movable longitudinally of the tube and comprising rollers 57 mounted on plates 55, 55a rotatable in the opposite direction to the first head to counteract torsional stress. Synchronous rotation of the rollers 57 is achieved through idler gears 109 meshing with a toothed flange on each roller. Similar idler gears 19 are provided for the rollers 12. The axis of the rollers is angularly adjustable relative to the axis of the tube 11 to cause the rollers to form progressively deeper corrugations in the tube (Fig. 5, not shown) by means of screws 93 (Fig. 3, not shown) bearing on the roller axles. Adjustable stops such as nuts 63 limit this inward movement. The driving means for advancing the tube is connected through variable-speed transmission to the driving pulley for the first pressing head and the tube is advanced at the same speed as the rollers are rotated so that each turn of the helical pressing element of the rollers forms an annular groove which is progressively deepened by engagement of subsequent turns of the helical element. In an alternative embodiment, Fig. 6 (not shown), for forming a helical corrugation in the tube a single pressing head comprises rollers which carry annular grooves and are flared in the direction of tube advancement to achieve progressive deepening of the corrugation whilst the roller axis remains parallel to the tube axis.
Patent GB-1052691-A (GB)
IPC: A61G7/00
Abstract: 1,052,691. Bed-rests. COX OF WATFORD Ltd. March 25, 1965 [March 25, 1964], No. 12642/64. Heading A4J. A pillow rest frame 4 is pivoted to a supporting strut 5 which is pivoted at 8 to a head frame 2 of a bed. The pillow rest frame is attached to the head frame 2 by screw and nut mechanism 10, 13, Fig. 2 (not shown) so that its angle of inclination may be varied by means of a handle 12.
Patent GB-1143597-A (GB)
IPC: F16L23/10
Abstract: 1,143,597. Pipe couplings; pipe stoppers. H. K. PORTER CO. (GREAT BRITAIN) Ltd. 30 Nov., 1966 [21 Oct., 1965], No. 44653/65. Headings F2G and F2P. A pipe coupling for connecting stainless steel pipes or a pipe to another fitting such as a blanking off cap, comprises coupling parts 1 and 2, each having an annular joint face 3 for cooperation with the joint face of the other member and an external flange 5 extending outwardly and rearwardly from the joint face, and a channel-section clamping ring 6 embracing said flanges, said ring exerting a radial force on the remote ends of the flanges to deflect them radially inwards whilst constraining movement of said flanges in opposed axial directions so that the joint faces are forced axially towards each other. Pipe ends may be welded into each coupling part. The flanges are of general frustoconical shape and preferably extend at 20 degrees to the pipe axis, opposite flange surfaces being parallel, convergent, convex, or concave. The flanges may also be continuous or discontinuous. The clamping ring comprises a series of arcuate U-section members 7 spot-welded to a flexible metal strap 8, the ends of which are bent back to hold co-operating T-shape bolt and a T-shaped bolt receiving member, Figs. 2-4 (not shown). Alternatively a clamping ring having a toggle fastening may be used. Specifications 890,006, 885,996, 835,005, 790,625, 781,761, 735,271, 736,879, 732,442 are referred to with respect to clamping ring constructions. A gasket may be interposed between the joint faces or, an 0- ring seal may be seated in a recess in one or both joint faces.
Patent GB-1225995-A (GB)
IPC: B21C3/08
Filed: 1968-06-10
Abstract: 1,225,995. Drawing; rolling. NORTH AMERICAN ROCKWELL CORP. 10 June, 1968 [29 June, 1967], No. 27545/68. Headings B3M and B3P. A tapering die apparatus comprises at least three rotatable disc dies, means for causing relative movement between a workpiece and the dies such that the workpiece is drawn through the die orifice with a speed equal to the peripheral speed of the dies and means for maintaining the workpiece under tension. In one embodiment, Fig. 1, the workpiece is mtaintained under tension and a die carriage containing the disc dies 40 is moved over the workpiece. The disc dies 40 are connected to spur gears 25 and are rotated by the simultaneous movement of racks 20, or alternatively by the movement of the die carriage over stationary racks. The die peripheries may be shaped so as to form a workpiece having a maximum diameter at its ends and a minimum diameter intermediate thereof, or a workpiece having a non-constant taper. In another embodiment, Fig. 5, a disc die 63 is rotated by a drive shaft 73 to cause by bevel gearing 71 an adjacent pair of disc dies 61, 62 to synchronously rotate therewith. A tapered workpiece of triangular section is formed by the dies 61-63 or eight dies may be arranged to form a workpiece of octagonal section. The drive means of the two embodiments may be interchanged. A mandrel may be disposed within a tubular workpiece. In a further embodiment (Fig. 7, not shown), a tubular or solid workpiece (81) is pulled from a supply reel (83) through a pretensioning device (87), and through a die apparatus (91) by a drawing mechanism (85). The workpiece is finally cut into lengths by a saw (93).
Patent GB-1227173-A (GB)
IPC: H01L41/09
Filed: 1968-05-10
Abstract: 1,227,173. Oscillating motors; piezoelectric motors. CENTRE ELECTRONIQUE HORLOGER S.A. 10 May, 1968 [12 May, 1967], No. 22267/68. Heading H2A. [Also in Division G3] An electromechanical means for driving a timepiece comprises a mechanical resonator consisting of a rigid arm 4 carrying spaced masses 2, 3 and connected by at least one resilient arm to a fixed mounting member 13 for oscillation about an axis 20, and a pawl 15, 16 for converting the oscillatory motion of the resonator to a rotary motion of a ratchet wheel 17, and so arranged that a shock applied perpendicular to the axis 20 has a negligible effect on the motion of the pawl 15, 16. In the embodiment illustrated in Fig. 2 the pawl 15, 16 is secured by a pin 14 to the arm 4 to extend substantially parallel to the latter, and the arm 4 is connected by two parallel resilient arms 9, 10 to the mounting member 13. The mass 2 is constituted by a magnet which co-operates with an electromagnet 6 to oscillate the arm 4, the electromagnet 6 having coils 7, 8 energized either by alternating current or direct pulses, the frequency of which may be controlled by a quartz crystal oscillator and a frequency divider. The mass 3 has a part-circular periphery and a flat side 23 and is rotatable to adjust the position of its centre of gravity and thereby the natural frequency of oscillation of the resonator. In further embodiments (Figs. 3 and 4, not shown) the resonator is connected to its mounting by a single resilient arm. In another embodiment the electromagnetic device driving the resonator comprises a coil 75 (Fig. 6, not shown) carried by the resonator and co-operating with two fixed permanent magnets. A further construction constitutes a piezo-electric motor having a compound strip 96, Fig. 8, of polarized piezoelectric material held in a support 97 at one end where it has current supply leads 101, 102. The other end of the strip 96 carries a mass 103 connected by an arm 104 to a counterweight 105 carrying a pawl 106, 107 for driving a ratchetwheel 108. Excessive deformation of the strip 96 by a shock is prevented by a member 116 carried by the arm 104 and having an elongated hole 117 which receives a pin 118 secured to a fixed platen 95 (Fig. 7, not shown).
Patent GB-1228704-A (GB)
IPC: B29C65/74
Filed: 1969-01-09
Abstract: 1,228,704. Rotary cutters. CHAS. THRELFALL Ltd. 29 Dec., 1969 [9 Jan., 1969], No. 1367/69. Heading B4B. A rotary cutter comprises a cutting edge 13, electric heating element 14, the electricity being conducted through brushes 16 acting on slip rings 15 from an arm 10. The cutter may be rotated on a roller, needle, ball or gas bearing, the gas being supplied through a connection 10A, and cooling holes 20 may be provided. There may be more than one heating element Fig. 2 (not shown) or the heating element may be rectangular in cross-section Fig. 3 (not shown). The heating element may be made of Monel (Registered Trade Mark) metal or a copper-beryllium alloy and the cutting edge may be serrated or buckled to provide fluting. A covering 17 of asbestos may be provided. The arm 10 may carry a sensor for detecting the temperature of the edge 13 and appropriately controlling the supply of electrical energy. The arm 10 may be in the form of a handle for manual operation.
Patent GB-1228973-A (GB)
IPC: E02B13/00
Filed: 1968-08-06
Abstract: 1,228,973. Sluice gates. ESCHER WYSS Ltd. 6 Aug., 1968, No. 37493/68. Heading E1H. A sluice gate 3 slides vertically in recesses 4 in the side walls 11, 15, 14, 22 of a channel 1, 2 and has a flow separation edge 10 on the underside of the gate in the vertical plane 88 containing the edges 8 between the recesses and the side walls 11, 15 on the upstream side of the gate. Downstream of the recesses 4 each side wall 14, 22 of the channel may be either in or further from the channel axis than a vertical plane 13 containing the corresponding edge 8, the plane diverging downstream at an angle α of 45‹ to the stream axis. The bottom 11 of the channel upstream of the gate may also have a flow separation edge, formed by a step 77, in the vertical plane containing the loaded downstream surfaces 7 of the recesses 4, the width of which may be kept to a minimum to provide adequate strength for the flanges 6 of the gate. The upstream surface 9 of the gate is upstream of the plane 88.
Patent GB-1229651-A (GB)
IPC: C07D405/04
Filed: 1968-03-14
Abstract: 1,229,651. Isoindoles and isoindolines. AMERICAN HOME PRODUCTS CORP. 14 March, 1968 [14 March, 1967], No. 12411/68. Heading C2C. The invention comprises (subject to disclaimers with respect to Specifications 1,097,168,1,144,060 and 1,162,835) (1) compounds of formulµ and their addition salts with pharmaceutically acceptable acids, (2) a process for making the isoindoles by reacting a compound of formula with LiAlH 4 , and (3) processes for making the isoindolines by (a) reducing a phthalimidine of formula with LiAlH 4 , (b) (when R<SP>4</SP> = H and n= 3) catalytically reducing the corresponding isoindoles, or (c) (when R<SP>4</SP> = tosyl and n = 2 or 3) reducing a compound of formula where p = 2 or 3, with LiAlH 4 . In these formulµ, R<SP>1</SP> is C 1-6 , alkyl, Ph (possibly substituted by CF 3 , 1-2 halogen atoms or 1-2 C 1-6  alkyl or alkoxy groups), Ph-C 1-6  alkyl, thienyl, pyridyl, furyl or 5,6,7,8 - tetrahydro - 2 - naphthyl, R<SP>2</SP> are both H, halogen or C 1-6  alkyl or akoxy, or R<SP>2</SP> is H and R<SP>3</SP> is NH 2 , C 1-6 -alkyl NH, halogen or C 1-6  alkyl or alkoxy, R<SP>4</SP> is H or tosyl, R<SP>5</SP> is C 1-6  alkyl, m is 2 or 3, and n is 2-7. Therapeutic compositions for oral or parenteral administration comprise compounds of the first two formulµ above, which have anorexiant and antidepressant activity.