baber/WOPTO huggingface dataset:
Patent NZ-598131-A (NZ)
Title: Anti-angiogenesis therapy for the treatment of previously treated breast cancer
Inventor: HAMBLETON JULIE
IPC: G16H20/10
Filed: 2010-08-11
Abstract: Disclosed is the use of an anti-VEGF antibody in the manufacture of a medicament for treating a patient diagnosed with previously treated metastatic triple negative breast cancer, wherein the patient must have received a chemotherapy for the metastatic disease in a first-line setting, wherein the patient is subjected to a treatment regimen combining a chemotherapy as a second-line therapy for treating previously treated metastatic breast cancer with the administration of an effective amount of an anti-VEGF antibody, wherein the anti-VEGF antibody comprises a heavy chain of SEQ ID 1 and a light chain of SEQ ID 2; wherein the sequences are as disclosed in the specification, and wherein the chemotherapy of the treatment regimen in the second-line therapy comprises administration of at least one chemotherapeutic agent, selected from the group consisting of taxane therapy, capecitabine, gemcitabine and vinorelbine, and wherein the treatment regimen effectively extends the progression free survival of the patient.
Patent NZ-618954-A (NZ)
Title: Processing biomass
Inventor: MEDOFF MARSHALL
IPC: C12P19/02
Filed: 2010-05-18
Abstract: A method for fermenting a low molecular weight sugar to a product comprising: contacting a low molecular weight sugar, in a medium, with a sheet comprising functionalized lignocellulosic fibers and fermenting microorganisms immobilized on the fibers; fermenting the low molecular weight sugar under conditions suitable for converting said sugar to a product by the fermenting microorganisms; recovering the lignocellulosic fibers after conversion; and reusing the fibers in a second, subsequent conversion process.
Patent NZ-630921-A (NZ)
Title: Compounds and methods for enhanced cellular uptake
Inventor: BHAT BALKRISHEN
IPC: C12N15/113
Filed: 2014-04-30
Abstract: Disclosed herein are conjugated modified oligonucleotides of formula (I) that are complementary to a target RNA, wherein each N of Nm is, independently, a modified or unmodified nucleoside and m is 1 or 2; X1 and X2 are each, independently, a phosphodiester linkage or a phosphorothioate linkage; and MO is a modified oligonucleotide consisting of 8 to 25 linked nucleosides and comprising at least one nucleoside with a cEt modified sugar moiety, wherein the nucleobase sequence of the modified oligonucleotide is complementary to a microRNA. The conjugate facilitates cellular uptake of the modified oligonucleotide, resulting improved potency.
Patent NZ-702351-A (NZ)
Title: A system for piercing a sealing membrane
Inventor: BRISEBRAT JEAN-MICHEL
IPC: H01T19/04
Filed: 2013-05-31
Abstract: The invention relates to a system for piercing a membrane (18) closing a cavity (14) of a container, said system comprises a piercing member (110) configured to perforate the membrane (18) and an ionizing device for neutralizing electrostatic charge liable to be carried by said cavity (14). According to the invention, this ionizing device comprises the piercing member (110), which is designed to have ionizing properties. The invention also relates to a method for piercing at least one membrane (18) closing at least one cavity (14) of a container, involving piercing the membrane (18) in order to open said cavity (14), and neutralizing electrostatic charge liable to be carried by said cavity (14), in which the piercing of the membrane (18) and the neutralization of the electrostatic charge are achieved using one and the same piercing membrane (110) designed to have ionizing properties.
Patent NZ-702981-A (NZ)
Title: Selenium-enriched dietary supplement and method of manufacture thereof
Inventor: DUOGONG ZHU
IPC: A61K33/04
Filed: 2014-12-15
Abstract: A method of manufacture of a selenium enriched dietary supplement comprising: (a) obtaining a quantity of a wheat grain; (b) sprouting the quantity of wheat grain from step (a) on a selenium growth media; (c) growing the sprouted quantity of wheat grain from step (b) in a selenium growth media; and (d) producing a selenium-enriched liquid extract from the grown quantity of wheat grain cereal crop plant grain from step (c); (e) producing a liquid flavanol-enriched extract from at least one organic source of flavanols; and (f) mixing the selenium-enriched liquid extract from step (d) and the liquid flavanol-enriched extract from step (e).
Patent NZ-706813-A (NZ)
Title: Container having a dispense indicator
Inventor: HERMAN MEGAN
IPC: B67B1/06
Filed: 2013-10-03
Abstract: A product includes a dissolvable dispense indicator (14; 114; 214; 314; 414) carried by a container (12; 112; 212; 312; 412).
Patent NZ-712167-A (NZ)
Title: Boron-containing diacylhydrazines
Inventor: CHELLAPPAN SHEELA
IPC: C07F5/02
Filed: 2014-03-14
Abstract: The regulation of foreign gene expression can be problematic due to issues including non-specific effects on other (non-target) genes, leakiness, instability, toxicity, and/or undesirable side effects to the host. Improved ecdysone receptor-based gene regulation systems (e.g. those using diacylhydrazine (DAH) compounds) having superior physiochemical and/or pharmacological properties are desirable. The present disclosure provides boron-containing diacylhydrazines of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The compounds of the present invention can be beneficial in the precise control of gene expression by way of interacting with gene switches comprising a suitable binding domain for the compounds. The compounds can be used in pharmaceutical compositions and are advantageous in the treatment of diseases (e.g. various forms of cancer) due to their capacity to regulate gene expression via gene switches.
Patent NZ-714546-A (NZ)
Title: Methods and compositions for templated assembly of nucleic acid specific heterocompounds
Inventor: DUNN IAN
IPC: C12N15/11
Filed: 2014-06-04
Abstract: The present disclosure is directed methods and products for synthesizing and using targeted templated assembly reactants comprising at least one nucleic acid recognition moiety, at least one selectively-reactive moiety, and at least one effector partial moiety. The nucleic acid recognition moiety can bind a target nucleic acid sequence within a sample. The nucleic acid recognition moiety also can bind the selectively-reactive moiety. Additionally, the effector partial moiety can bind the selectively-reactive moiety to produce an active effector structure. Also disclosed are methods of delivering the targeted templated assembly reactants and active effector structures formed from the targeted templated assembly reactants.
Patent NZ-725399-A (NZ)
Title: Macrocylic pyrimidine derivatives
Inventor: MEERPOEL LIEVEN
IPC: C07D498/22
Filed: 2015-04-02
Abstract: The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Patent NZ-729608-A (NZ)
Title: Surgical eye shield
Inventor: WALLIS ANDREW
IPC: A61F9/02
Filed: 2015-08-21
Abstract: An eye shield for overlaying the orbital rims of a patient’s face, including a resiliently deformable base (20) having first and second apertures (22, 24) corresponding to the position of the eyes. The base includes an adhesive layer (26) on an underside for attachment to the face. The eye shield also includes a curved, flexible, transparent cover plate (32) attached to an upper surface of the base and extending over the first and second apertures. The cover plate includes first and second eye cover portions (36, 38) joined by an integral hinge member (40), wherein the eye cover portions are configured to pivot relative to each other around said hinge member and flex along at least a part of their respective spans to generally conform to the shape of the face. The cover plate is of unitary construction, the hinge member extending down the cover plate, from a top end to a bottom end at a mid region corresponding to the position of the bridge of the patient’s nose. The invention provides an shield that inhibits direct pressure being applied to a patient’s eyes during surgical procedures, thus avoiding injury, while simultaneously allowing a medical practitioner to maintain visibility of the eyes.
Patent NZ-730759-A (NZ)
Title: 1,2-benzothiazole compounds for the treatment of kidney disorders
Inventor: GENIN MICHAEL JAMES
IPC: C07D417/06
Filed: 2015-11-13
Abstract: The present invention provides 1,2-benzothiazole compounds particularly useful in the treatment of diabetic nephropathy and other chronic kidney disorders and other diabetic complications.
Patent NZ-737576-A (NZ)
Title: Device and corresponding method for producing honeycombs for apiculture
Inventor: FERRER VIDAL CARLOS
IPC: A01K47/04
Filed: 2016-02-29
Abstract: The invention relates to a device and corresponding method for producing honeycombs for apiculture by moulding a continuous honeycomb element from which the honeycombs for installation in the beehives are individually cut. The device comprises two continuous belts disposed in parallel and carrying opposing cores, the belts acting on wax in a liquid state which is inserted into the entry of the device, with both moving belts in opposition. The entry comprises, successively: a scraping zone disposed straight with respect to the band; a zone for opening the cores, which has a certain curvature designed to receive the first injection of wax; and a third straight zone for sealing and expelling the excess wax, and the exit, the longest length of the upper belt, comprises multiple groups of magnetic and non-magnetic rollers for the local curving of the belt to progressively release the honeycomb. The device is intended to overcome the shortcomings of a previous device i.e. relative slowness of the process, the possible contamination by the iron powder, the difficulty of producing effective magnetic pulses, because the strip is separated at the beginning and requires a very powerful field, and the loss of magnetic energy due to the dispersion of the field and the relative fragility of the honeycombs produced.
Patent NZ-740678-A (NZ)
Title: Flexible package and method of making the same
Inventor: SANFILIPPO JAMES
IPC: B65D75/44
Filed: 2013-10-25
Abstract: An apparatus for making flexible packages each having a plurality of walls and leading and trailing seals is disclosed. The apparatus includes a folding and edge sealing station to fold a web of flexible material around a forming tube such that a perimeter edge of the flexible material is sealed and a portion of the plurality of walls of the package are defined, the sealing station comprises tuckers a seal bar and a cutting device to separate the packages. A support structure is located downstream of the sealing station, wherein once the first package is cut from the second package, the second package travels downstream and engages with the support structures such that the leading seal of the second package rests against the support structure in a configuration in which it is folded over against a wall of the second package from which the leading seal extends. A flap folding station is located upstream of the support structure and comprises a retaining structure and one or more pressure plates to engage the trailing seal of the second package and fold the trailing seal over towards the wall of the second package from which it extends.
Patent NZ-743487-A (NZ)
Title: Controlled-release cnp agonists with increased nep stability
Inventor: RAU HARALD
IPC: A61K47/50
Filed: 2017-01-05
Abstract: The present invention relates to controlled-release CNP agonists having an at least 5-fold longer degradation half-life in an in vitro NEP degradation assay than the corresponding released CNP agonist, where the controlled-release CNP agonists comprise a CNP moiety conjugated to a PEG-based hydrogel via a reversible prodrug linker of formula (V). Also disclosed are pharmaceutical compositions comprising said controlled-release CNP agonist, their use and to methods of treatment.
Patent NZ-752353-A (NZ)
Title: Antifungal dry powders
Inventor: SUNG JEAN C
IPC: A61K9/14
Filed: 2017-10-13
Abstract: The presently claimed invention relates to dry powder formulations comprising respirable dry particles that contain 1) itraconazole in crystalline particulate form, b) a stabilizer, and c) leucine.
Patent NZ-757510-A (NZ)
Title: Refrigerator
Inventor: ZUO LIHUA
IPC: F25D23/12
Filed: 2018-10-12
Abstract: A refrigerator, comprising a box body, a door body and a drinking water apparatus (100). The drinking water apparatus (100) comprises a water container (10), water discharge tubes (1, 2), a beverage preparation chamber (14) and a dispenser (3), the beverage preparation chamber (14) being connected to the dispenser (3). The drinking water apparatus (100) also comprises an integration module (17) arranged between the water container (10) and the beverage preparation chamber (14), the integration module (17) comprising a water pump (12) to produce pressurized water and a heater (13) to produce hot water. There are two selector switches the first to control the flow of hot water to the dispenser or the beverage preparation chamber, and the second to control the flow of pressurized water to the beverage preparation chamber or the heater. The refrigerator provided with the integration module (17) can be selected for beverage warming, pressurisation and/or concentration adjustment during beverage preparation, so as to enable a user to prepare beverages in a variety of flavours, and implement the diversification of refrigerator drinking water functions.
Patent NZ-760241-A (NZ)
Title: A Structural Laminated Post
Inventor: JOHN DENNIS WOODMAN
IPC: B32B7/00
Filed: 2018-12-17
Abstract: A difficulty with glued laminated timber is maintaining durability and strength when used for in-ground situations. Described herein is a structural laminated post, the post manufactured from a combination of shooks, the shooks having a generally planar shape with random length and ending and a width, the shooks being laminated together about their planar surfaces to collectively form the post shape, the post further comprising an above ground portion and an in-ground portion. In one aspect, at least the external surface of the in-ground portion of the post is chemically sealed. In an alternative aspect, the shooks of the above ground and in-ground portions are adhered together using at least one common adhesive and no sealing is required. Methods of manufacturing the posts are also described. The configurations described provide a structural laminated post for in ground applications for strength and longevity that meets code of compliance.
Patent PT-101516-A (PT)
Title: Room air-conditioning installation - has heating and cooling sources connected to common heat transfer device through which preheating, further heating and cooling occurs
Inventor: ROLIN INGMAR
IPC: F24F3/00
Filed: 1994-05-12
Abstract: The air conditioning installation includes heating (11) and cooling (14) sources connected to a circulation pipeline system (9) of the heat transfer device through a valve controlled by an air temperature sensor. The heat transfer device preheats the supply air (A) by transferring heat from exhaust air (B) into the supply air. Heating and cooling sources heat and cool the supply air and are controlled on the basis of the temperature of the air sensed by an adjusting device. The system allows selectively only heat transfer fluid (c) and/or further heating fluid (D) in an adjustable ratio or only cooling fluid (E) to enter a second heat exchanger.
Patent PT-103843-A (PT)
Title: Método de isolamento de células precursoras a partir do cordão umbilical humano
Inventor: SOARES RITA ISABEL GANCHAS
IPC: C12N5/22
Filed: 2007-10-04
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM MÉTODO OPTÍMIZADO E DEFINIDO DE ISOLAMENTO E PRESERVAÇÃO DE CÉLULAS PRECURSORAS, A PARTIR DO CORDÃO UMBILICAL HUMANO. PARA ALÉM DE SER REPRODUTÍVEL E 100% EFICAZ, EM TERMOS DE NÚMERO DE AMOSTRAS PROCESSADAS, O PRESENTE MÉTODO PERMITE ISOLAR UM ELEVADO NÚMERO, DEFINIDO, DE CÉLULAS COM CARACTERÍSTICAS PRECURSORAS, A SUA MAIORIA APÓS APENAS UMA FASE DE ADESÃO E EXPANSÃO/MULTIPLICAÇÃO EX VIVO (GARANTINDO ASSIM A SUA IDENTIDADE FENOTIPÍCA), NUM INTERVALO DE TEMPO MAIS CURTO QUE OS ANTERIORMENTE DESCRITOS NO ESTADO DA ARTE. COM ESTE MÉTODO É POSSÍVEL OBTER, EM 9 DIAS, APÓS CONGELAÇÃO DIRECTA DUMA FRACÇÃO DAS CÉLULAS, E APÓS UMA FASE DE ADESÃO E EXPANSÃO/MULTIPLICAÇÃO EX VIVO (FINAL DE PO), DA MAIORIA DAS MESMAS, RENDIMENTOS NA ORDEM DAS 8,6(±0,L)X105 CÉLULAS/GRAMA DE CORDÃO UMBILICAL PROCESSADO. AS CARACTERÍSTICAS DAS CÉLULAS PERMITEM, POR EXEMPLO, E AO FINAL DE 35 DIAS, OBTER UMA MÉDIA DE 7,7X1015 CÉLULAS COM CARACTERÍSTICAS PRECURSORAS, A PARTIR DE 100% DAS AMOSTRAS DE CORDÃO UMBILICAL PROCESSADAS. O MÉTODO OBJECTO DA PRESENTE INVENÇÃO, POR SER SIMPLES ,ROBUSTO, E 100% EFICAZ, PODE SER APLICADO SOB BOAS PRÁTICAS DE FABRICO (GMP) EM LABORATÓRIOS DE SERVIÇOS DEDICADOS À TERAPIA CELULAR EM HUMANOS. PARA ALÉM DISSO, O MÉTODO TEM APLICAÇÃO NAS ÁREAS FARMACÊUTICA, COSMÉTICA E DA BIOTECNOLOGIA.
Patent PT-115247-A (PT)
Title: Sistema de componentes para montagem modular de ''zonas húmidas artificiais''
Inventor: HENRIQUE JOAQUIM DE OLIVEIRA PINHO
IPC: C02F3/32
Filed: 2019-01-08
Abstract: A PRESENTE INVENÇÃO DIZ RESPEITO A UM DISPOSITIVO PARA MONTAGEM DE ZONAS HÚMIDAS ARTIFICIAIS (ZHAS) MODULARES AMOVÍVEIS E DE FORMA E DIMENSÕES ADAPTÁVEIS, CUJA UTILIZAÇÃO PERMITE A INSTALAÇÃO DE ZHAS SEM NECESSIDADE DE INFRAESTRUTURAS PERMANENTES E A ADAPTAÇÃO DAS ÁREAS DAS ZHAS ÀS NECESSIDADES TEMPORAIS/SAZONAIS ESPECÍFICAS E/OU LOCAIS. PARA ESSE EFEITO, SÃO DESENVOLVIDOS COMPONENTES ESTRUTURAIS INDIVIDUAIS (9), QUE PODEM SER TODOS IGUAIS, OU POSSUIR LIGEIRAS MODIFICAÇÕES, OS QUAIS, QUANDO LIGADOS ENTRE SI, RESULTAM EM ZHAS MODULARES DE DIMENSÃO E FORMA VARIÁVEIS E MODIFICÁVEIS. CADA COMPONENTE ESTRUTURAL (9)COMPREENDE UM DETERMINADO NÚMER O DE TRAVESSAS HORIZONTAIS (3) E DE BARRAS VERTICAIS (1), FURAÇÕES E/OU OUTROS ELEMENTOS DE LIGAÇÃO (2) ENTRE COMPONENTES, PARA PERMITIR CRIAR AS ZHAS MODULARES. O CONJUNTO DOS COMPONENTES ESTRUTURAIS, LIGADOS ENTRE SI, REVESTIDOS POR UMA TELA IMPERMEÁVEL(4), ONDE SºAO COLOCADOS OS TUBOS DE ENTRADA E SAÍDA DE ÁGUA (5), CONSTIUEM A ZHA MODULAR. A GEOMETRIA E DIMENSÃO DE CADA ZHA MODULAR, CONSTRUÍDA PELA LIGAÇÃO DOS COMPONENTES ESTRUTURAIS, E REVESTIDA PELA TELA IMPERMEÁVEL (4) PODE VARIAR EM FUNÇÃO DA APLICAÇÃO DESEJADA, PERMITINDO QUE AÁREA ÚTIL DE TRATAMENTO SEJA VARIÁVEL E ASSIM, ADADPTADA ÀS NECESSIDADES. DESTA FORMA, A PRESENTE INVENÇÃO ENCONTRA- SE NO DOMÍNIO DO TRATAMENTO DE ÁGUAS RESIDUAIS COM RECURSO A ZONAS HÚMIDAS ARTIFICIAIS (ZHAS).
Patent RU-94011957-A (RU)
Inventor: ISUPOV V P
IPC: C01F7/04
Filed: 1994-04-05
Abstract: FIELD: composition materials. SUBSTANCE: source of parental compounds containing aluminium and transient metal is an intercalating compound of aluminium hydroxide of the following composition: MeMe•ЭДТА•4Аl(OH)•pHO where Me- lithium or two-charge metal cation of the raw: Mg, Zn, Ni, Co; Me- Cu or Co or Ni. Method involves the heating under vacuum at 350-450 C for at least 0.5 hr, not less. EFFECT: simplified and accelerated process.
Patent RU-94018895-A (RU)
Inventor: BELOBRATOV JU A
IPC: B24B7/02
Filed: 1994-05-25
Abstract: FIELD: machine engineering. SUBSTANCE: flat grinding electromechanical machine tool, including frame 1, a cross-like rest with carriage 3 and longitudinal table 2, a spindle strut with a grinding head, electromechanical drive units 4 for lengthwise and cross motions of the table, a reduction gear and a drive unit for vertical motion of the grinding head, mechanisms for manual motion of the table and the grinding head, also includes electromechanical drive unit 4 for longitudinal motion of the table with hollow driven pulley 5, through which spline shaft 6 is passed. One end of the shaft 6 is freely joined with gear wheel-pulley 7 of the reduction gear longitudinal motion of the table 2, the pulley 7 is mounted on the carriage 3. Another end of the shaft is stationary joined in axial direction and connected with flywheel 9 of the mechanism 10 for manual motion of the longitudinal table 2, the flywheel is arranged in the frame 1. The gear wheel-pulley is embraced by a rope, for example by toothed belt 11, whose outlet ends, resting upon additional rollers, mounted in an upper portion of the reduction gear, are rigidly jammed at both end sides of the longitudinal table. The reduction gear for vertical motion of the grinding head is provided by a braking device, having two solenoid-type couplings, mounted on a drive shaft of the reduction gear and connected one with a driven pulley of the drive unit, and another - with a body of the reduction gear 22. The couplings are mutually joined by remote control fashion with pickups of a cross-type switch-over, mounted on the side of the machine tool. EFFECT: enhanced structure of the machine tool.
Patent RU-94022697-A (RU)
Inventor: KUTUKOV A V
IPC: F01L21/00
Filed: 1994-06-10
Abstract: FIELD: mechanical engineering; engines. SUBSTANCE: in offered version, after working stroke of piston and scavenging of cylinder, compression of fresh charge takes place. But, as distinct from two-stroke engine, fuel is not delivered to cylinder and piston does not execute its working stroke. Having passed over TDC, piston moves downwards, and compressed charge expands and, like spring, returns power taken for its compression. Then second scavenging of cylinder is effected, fresh charge is compressed and working stroke of piston takes place. So engine has four strokes: working stroke with subsequent scavenging, compression of fresh charge, return stroke of piston with second scavenging and compression of fresh charge. Quality of gas exchange is enhanced owing to second scavenging. Offered invention makes it possible to create four-stroke engine with high quality of gas exchange on base of two stroke internal combustion engine with contour gas exchange system in which quality of gas exchange is not sufficiently high. EFFECT: simple design and reliable construction without the use of valve timing gear. 2 cl
Patent RU-94023635-A (RU)
Inventor: KOLESNIKOV I M
IPC: C10G35/095
Filed: 1994-06-21
Abstract: SUBSTANCE: zeolite-containing catalyst is treated with solution that is the modifying agent-complex of siloxane with metal. Treatment is carried out by passing solution through the catalyst at volume rate 0.5-1.5 $$$, at 70-80 C for 1-3 h. Then gasoline fraction reforming is carried out on the treated catalyst. EFFECT: improved method of treatment.