baber/WOPTO huggingface dataset:
Patent EP-4218409-A2 (EP)
Title: Mice expressing a limited immunoglobulin light chain repertoire
Inventor: BABB ROBERT
IPC: A01K67/027
Filed: 2014-03-13
Abstract: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.
Patent EP-4239826-A2 (EP)
Inventor: SKLIUTAS JOHN PAUL
IPC: H02J3/38
Filed: 2023-02-15
Abstract: A power system (100) includes a turbine assembly (104) including a turbine (132) and a turbine shaft (134), a generator assembly (106) including a generator (114) and a generator shaft (116), an inertia assembly (108) including a flywheel (144) coupled to the generator shaft (116), and a clutch assembly (120) for coupling the turbine shaft (134) to the generator shaft (116). The clutch assembly (120) is transitionable between a closed state, in which the turbine shaft (134) is coupled to the generator shaft (116), and an open state, in which the turbine shaft (134) is decoupled from the generator shaft (116). The power system (100) is operable in a power generation mode when the clutch assembly (120) is in the closed state and a synchronous condenser mode when the clutch assembly (120) is in the open state.
Patent EP-4234571-A2 (EP)
Title: Viral vectors with modified transduction profiles and methods of making and using the same
Inventor: ASOKAN ARAVIND
IPC: C07K14/075
Filed: 2012-02-10
Abstract: The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
Patent EP-4234772-A2 (EP)
Inventor: BUENO MARCOS ROBERTO PAULINO
IPC: D01D1/02
Filed: 2015-12-02
Abstract: A polymeric yarn comprised of polyethylene, having a high microstructural order characterized by one or more of the following microstructural parameters, determined by a two-dimensional (2D) small-angle X-ray scattering (SAXS) diffractogram of the polymeric yarn: i) an average aspect ratio of nanopores, AR v , of greater than 50; ii) an angular dispersion of the nanopores, βv, of less than 40 mrad; iii) a drawability of the crystalline phase, Λ, of greater than 0.2; iv) an average aspect ratio of the crystallites, AR c , of greater than 1; and v) a short period lamellar microstructure fraction, f L , of less than 0.1.
Patent EP-4272765-A2 (EP)
Title: Adeno-associated virus (aav) clade f vector and uses therefor
Inventor: WILSON JAMES M
IPC: A61K48/00
Filed: 2018-02-27
Abstract: A recombinant adeno-associated virus (rAviV) vector comprising an AAVhu68 capsize produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsize comprises subpopulations of highly deamidated asparagine residues in asparagine - glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAviV and uses thereof. Additionally, rAviV having an engineered AAV capsize comprising at least one subpopulation of vpl or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vpl numbering are provided.
Patent EP-4273488-A2 (EP)
Title: Four à fort rendement énergétique
Inventor: DUPEUX GUILLAUME
IPC: F27D99/00
Filed: 2021-04-26
Abstract: L'invention concerne un une installation 1 pour la fusion d'une composition de matières premières, adaptée à l'obtention de laine de verre, de fils de verre textile et/ou de verre plat, qui comprend une chambre de fusion 2 équipée d'au moins un brûleur 3 de type immergé, caractérisée en ce que la chambre de fusion 2 est définie par des parois latérales 4 en matériau réfractaire et une sole 5 métallique nue parcourue d'un réseau de conduites adaptées pour la circulation d'un fluide de refroidissement, préférentiellement de l'eau.
Patent EP-4256986-A2 (EP)
Inventor: YAMADA MANABU
IPC: A24F40/30
Filed: 2019-10-30
Abstract: A power supply unit for an aerosol inhaler includes: a power supply that is able to discharge power to a load for generating an aerosol from an aerosol generation source; and a control unit that is configured to control at least one of charging and discharging of the power supply such that the power supply does not become one or both of a fully charged state and a discharging termination state.
Patent EP-4248915-A2 (EP)
Inventor: HARITON ILIA
IPC: A61F2/24
Filed: 2018-12-12
Abstract: Apparatus for use at a native valve of a heart of a subject comprises a delivery tool 100, comprising a shaft 106, having a shaft-axis ax2; a capsule 110, disposed at a distal portion 104 of the tool, and comprising an upstream capsule-portion 112 and a downstream capsule-portion 114, the capsule being openable by moving the upstream capsule-portion and the downstream capsule-portion apart; and a balloon 120, coupled to the shaft, and disposed within the capsule; and a prosthetic valve, comprising a tubular frame that circumscribes a longitudinal axis to define a lumen along the longitudinal axis, that is compressed around the balloon, and that is disposed within the capsule; and an outer frame, the outer frame comprising one or more shape-memory flanges, constrained within the downstream capsule-portion; and a shape-memory upstream support portion, constrained within the upstream capsule-portion. The flanges are configured to automatically deflect radially outward from the tubular frame upon exposure from the downstream capsule-portion, the upstream support portion is configured to automatically deflect radially outward upon exposure from the upstream capsule-portion, the tubular frame is configured to remain compressed around the balloon upon exposure of the tubular frame from the capsule, the outer frame is disposed radially outward from the tubular frame and longitudinally overlapping the tubular frame, and while the tubular frame is exposed from the capsule the tubular frame is configured to inhibit the outer frame from radially expanding, prior to inflation of the balloon, and inflation of the balloon plastically expands the tubular frame radially.
Patent EP-4306542-A2 (EP)
Inventor: NOVOTNY JAMES JR
IPC: C07K16/28
Filed: 2018-05-30
Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.
Patent EP-4283900-A2 (EP)
Inventor: KHOSHNEVISAN MOSTAFA
IPC: H04L1/1829
Filed: 2020-03-19
Abstract: Methods, systems, and devices for wireless communications are described that provide for group or one-shot acknowledgment (ACK) feedback reporting, in which feedback for a number of different downlink transmissions may be provided by a user equipment (UE) to a base station. A base station may trigger a one-shot feedback report that includes less than all of the ACK feedback that is available at the UE to provide in a report. The ACK feedback may include an indication of an ACK or a negative acknowledgement (NACK) along with information related to a data indicator associated with the downlink transmission. In some cases regular ACK feedback reports and one-shot feedback reports may be multiplexed and transmitted by a LTE. Further, a last downlink transmission to be included in a one-shot feedback report may be determined based on a receipt time of scheduling information or an ACK feedback timeline.
Patent EP-4289991-A2 (EP)
Inventor: DESAI MEHUL
IPC: C25B15/02
Filed: 2017-02-02
Abstract: An industrial system (20) for heating, drying, or curing, comprising an electrolyser (700) for producing hydrogen fuel from water; at least one heating element for using the hydrogen fuel; and a processor for controlling the at least one heating element such that the at least one heating element is adapted to use the hydrogen fuel under control of the processor; wherein the processor is connected to a network to enable communication to a server, the server having at least one module for providing at least one of monitoring or control of the operation of the system (20); and wherein the electrolyser (700) is controlled by the processor and adapted to generate the hydrogen fuel under control of the processor and responsive to an indication of use of the hydrogen fuel.
Patent EP-4294114-A2 (EP)
Title: Information reporting
Inventor: ZHENG QIAN
IPC: H04W76/27
Filed: 2019-09-02
Abstract: An information reporting method, a receiving method, user equipment, and a network device are provided. The information reporting method comprises: sending a RRC resume request message to a network device; receiving a first RRC message sent by the network device in response to the RRC resume request message; and sending a second RRC message in response to the first RRC message to the network device, wherein in a case that the user equipment is in an inactive mode, when a PLMN reselects to an EPLMN, or when PLMN reselects to EPLMN and RNA update conditions are met, the second RRC message carries the identity of EPLMN.
Patent EP-0004555-A2 (EP)
Title: Résine sensible aux électrons comportant un sel métallique d'un méthacrylate et application à la lithographie à faisceau d'électrons
Inventor: HATZAKIS MICHAEL
IPC: G03F7/004
Filed: 1979-03-02
Abstract: La présente invention concerne une résine sensible aux électrons, constituée par un polymère non réticulé qui comporte: a) des unités polymérisées de méthacrylate d'alkyle dans lesquelles le groupe alkyle contient de 1 à 4 atomes de carbone et b) des unités polymérisées d'un sel de l'acide méthacrylique et d'un métal, ce dernier étant choisi dans le groupe composé du baryum, du calcium, du strontium, et du plomb, la quantité des unités de type a) est comprise entre 50% et 99,99% en mole et la quantité des unités de type b) est comprise entre 50% et 0,01% en mole du nombre total de mole, tandis que le métal constitue de 0,001% à 10% en poids du polymère. Le métal préféré est le plomb. Cette résine trouve application dans les étapes lithographiques de la fabrication des circuits intégrés à semi-conducteurs, car elle présente en particulier un rapport de solubilité S/So (entre les parties exposées et non exposées) plus élevé que les résines classiques de type polyméthacrylate de méthyle (PMMA), pour une exposition donnée.
Patent EP-0013376-A2 (EP)
Inventor: KAMMERER FRIEDRICH-JOHANNES DR
IPC: C07D261/18
Filed: 1979-12-13
Abstract: 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid und Verfahren zu seiner Herstellung werden beschrieben. Die Verbindung wirkt antirheumatisch, antiphlogistisch, antipyretisch und analgetisch sowie gegen multiple Sklerose.
Patent EP-0027704-A2 (EP)
Inventor: CHAMNESS DALE L
IPC: A61B18/00
Filed: 1980-10-09
Abstract: A surgical cannula apparatus (Figure 1) includes a sheath (32) having proximal and distal ends, a flexible member (34) in the sheath and movable longitudinally therein, the member (34) having proximal and distal ends, and a surgical instrument (104) operable by movement of the member (34) with respect to the sheath. The apparatus further includes an operating device (10) comprising a body (12) which slidably receives a slide (48) for movement longitudinally of the body. The body (12) has a generally cylindrical interior and the slide (48) has a pair of longitudinally spaced walls (44,46) of circular shape. The walls have aligned apertures which rotatably receive a stem (70) which has proximal and distal ends, and the proximal end of the flexible member (34) is fixed to the distal end of the stem (70). The proximal end of the sheath (32) is fixed to the body (12). The stem has a thumbwheel (84) accessible through the wall of the body, the thumbwheel being manipulatable to rotate the member (34) in the sheath (32). The slide (48) includes a rack and the body supports an additional thumbwheel (58) having gear teeth which engage the rack. Manipulation of the second thumbwheel causes the slide (48) to move longitudinally within the body to move the flexible member (34) longitudinally in the sheath.
Patent EP-0035711-A2 (EP)
Inventor: STEINER GERD DR
IPC: A61K31/50
Filed: 1981-02-27
Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.
Patent EP-0046510-A2 (EP)
Inventor: STEINER HELMUT
IPC: F16D65/22
Filed: 1981-07-22
Abstract: 1. Support bearing for a brake shaft of brake with internal shoes having a support plate secured to the axle body and two sheet metal shells connected therewith together with a bearing bush clamped between the sheet metal shells, characterised in that, the bearing bush consists of rubber, the bearing bush (9) being pre-stressed with the sheet shells (7, 8) is secured against slipping on the brake shaft (4).
Patent EP-0057274-A2 (EP)
Inventor: MITCHELL JOAN LAVERNE
IPC: H04N1/417
Filed: 1981-11-25
Abstract: A system for encoding images by assigning variablelength code words to fixed positions in a dynamic stack. Each position in the dynamic stack is occupied by a representation of an encodable image feature, such as a run-length or a vertical correlation. These codes are arranged in order of their respective frequencies of occurrence. The order in which these features are stacked is varied dynamically by the system, in accordance with their respective frequencies of occurrence and a predetermined scheme. Thus, the system can adapt to different types of documents being scanned, or to changes of scanning resolution. A relationship extists between the code words and the stack positions, which are not permanently assigned to specific image features. This arrangement ensures that the lengths of code words will be inversely related to their frequencies of occurrence under all conditions.
Patent EP-0039107-A2 (EP)
Inventor: BEKOOIJ JURRIANUS
IPC: C08G59/14
Filed: 1981-04-10
Abstract: Resinous compounds, for aqueous thermosetting coating dispersions or solutions after neutralization, are prepared by reacting a diglycidyl ether of a dihydric phenol with a mono-carboxylic acid and dimerized unsaturated fatty acids, with epoxy equal to or in slight excess over carboxyl, below 150°C in the presence of an epoxy/carboxyl esterification catalyst to produce a non-acidic intermediate, and reacting the intermediate below 150°C with a polycarboxylic acid anhydride in amounts to provide an acid value from 5-35; aqueous dispersions are prepared by at least 50% neutralization of compounds having acid value 5-15.
Patent EP-0054330-A2 (EP)
Inventor: VERRIPS CORNELIS THEODORUS
IPC: C12N15/00
Filed: 1981-12-11
Abstract: The invention relates to DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles comprising said DNA sequences and their use in transforming microorganisms.
Patent EP-0037731-A2 (EP)
Inventor: FANTOZZI LOUIS J
IPC: G03G15/06
Filed: 1981-04-07
Abstract: The present invention relates to an electrostatographic machine having a toner dispensing control (using a sensor approach directly measuring developed images to eliminate toner mass variations), and a bias control maintaining optimum density images on the photoreceptor in spite of changing humidity conditions. Two test targets, each having two test patches, are selectively exposed to provide test data in the photoreceptor image area for suitable sensing and control of thetoner dispensing and bias control loops.
Patent EP-0037756-A2 (EP)
Inventor: SCHWEIGHOFER NORMAN JOHN
IPC: H01R13/432
Filed: 1981-03-16
Abstract: An electrical connector assembly (100) comprises a plurality of contacts (10) removably mounted in densely packed cavities (73) of a connector housing (70), each cavity having a contiguous keyway slot (74) and oppositely inwardly facing shoulders (75,76). Each contact (10) includes a resilient tine (20) having an edge (21) for engaging the rear shoulder (76) to prevent withdrawal from the cavity, a locator key (30) adapted to be received in the keyway slot (74) and for orienting the tine and engaging the forward shoulder (75) to limit inward placement of the contact in the cavity and a rolled shoulder (40) having an installation abutment surface (41) at the rear (14) end of the sleeve, proper orientation of the tine allowing dense packing of the cavities and their associated contacts.
Patent EP-0067316-A2 (EP)
Inventor: ABBATE GIAMPIERO
IPC: H04N7/01
Filed: 1982-05-14
Abstract: Digital scan converter for transforming into a standard television signal an input video signal having different scanning characteristics. it includes an analogue to digital converter (2) supplied with the input signal and driving a main memory (8) as determined by a write-address generator (27). The main memory drives an output digital to analogue converter (13) as determined by a read-address generator (37). A multiplexer (9) alternately connects the address generators with memory (8) according to a clock signal. 
     A FIFO memory (4) stores data from converter (2) at the scanning rate of the input signal and supplies them to the main memory at the clock signal rate. If the input signal scanning is other than a cartesian scanning, memory (8) is written by columns and read by rows. 
     A couple of parallel connected FIFO memories (11, 12) alternately connect the main memory to converter (13) and supply the output data with a timing which is variable in order to restore the input signal.
Patent EP-0070615-A2 (EP)
Inventor: STOCKMASTER EDWARD F
IPC: H05K7/14
Filed: 1982-05-20
Abstract: 57 A module mounting unit (10), formed from a pair of side plates (12a, 12b) and a series of U-shaped cross-members (14c, 14s) mounted between the side plates, slidably retains a series of printed circuit board modules (16) by sliding the modules in guideways (34a, 34b) provided in the module mounting unit. The modules (16) each have a resilient tab (32) having a prong with a tapered head. The module mounting unit (10) has a series of front apertures (26) formed to allow the head of each module to engage such an aperture upon full insertion of the module, thus precluding withdrawal of the module from the mounting unit. The cross-members (14c, 14s) each have a series of the spaced apertures (26) along one leg (28) of the U for engaging the tabs (32) of the modules and a series of alternately-spaced circular and oval apertures (40, 42) to facilitate mounting of the module guideways (34a, 34b) to the module mounting unit.
Patent EP-0091030-A2 (EP)
Inventor: GROHN WOLFGANG
IPC: B66C13/48
Filed: 1983-03-24
Abstract: 1. A speed controller for a remotely-controlled transporting device, in particular an articulated ship-board crane (2), wherein a top control lever (6) is mounted on a base control lever (4) rotatable about a stationary swivel joint (3) by a swivel joint (5), and wherein respective drives (3a, 5a) are provided for the base control lever (4) and the top control lever (6), each equipped with a respective speed regulator and wherein a computer (12) supplied with control signals dependent upon the actual value (beta) of the angle of rotation between the top control lever and the base control lever and control signals (V1 ; V2 ) from a theoretical value regulator (13) which is adjustable by a control lever (13a) and which possesses potentiometers (13b; 13c) which are spatially displaced by 90 degrees and serve to form the control signals (V1 ; V2 ) which are proportional to the amount and the deflection in the x- and y-direction of a coordinate system in order to provide a control signal (nA ) for the speed regulator (11) of the top control lever (6) and a control signal (nB ) for the speed regulator (10) of the base control lever (4), where for the speed control the two potentiometers (13b; 14b) are connected to voltage and the output of the one potentiometer (13b) is connected to calculating modules (22, 24, 25; 45 to 50) in order to solve the equation : nA = - V1 /sin beta . K and the output of the other potentiometer (13c) is connected to calculating modules (23 to 19) in order to solve the equation : nB = -nA (1-cos beta) - V2 . K ; where nA signifies the speed of rotation of the base control lever ; nB signifies the speed of rotation of the top control lever ; V1 signifies the load speed component in the direction of the top control lever ; V2 the load speed component at right angles to the top control lever ; beta is the angle between the base control lever and the top control lever ; and K represents a constant.
Patent EP-0093448-A2 (EP)
Inventor: SKOLAUDE WERNER DIPL-ING
IPC: F25J3/04
Filed: 1983-05-02
Abstract: Bei einem Verfahren zur Gewinnung von gasförmigem Sauerstoff unter erhöhtem Druck durch Tieftemperaturrektifikation von Luft wird die Luft 1 zunächst komprimiert 2, dann gereinigt 3, 4 und mindestens zum Teil in einer ersten Wärmetauscheinrichtung 6 in Wärmetausch mit Zerlegungsprodukt abgekühlt und in die Rektifikation geleitet. Ein zweiter Gasstrom 8 wird auf einen höheren Druck verdichtet, in einer zweiten Wärmetauscheinrichtung 10 in Wärmetausch mit Zerlegungsprodukt abgekühlt, entspannt 11 und ebenfalls in die Rektifikation geleitet. Sauerstoff 16 wird in flüssiger Form aus der Rektifikation entnommen, auf den gewünschten Druck gepumpt und im Wärmetausch mit dem auf höheren Druck verdichteten Gasstrom 8 verdampft und angewärmt. Ein dritter Teilstrom 12 der zu zerlegenden Luft wird in Wärmetausch mit Zerlegungsprodukt abgekühlt.
Patent EP-0101063-A2 (EP)
Inventor: SEIPKE GERHARD DR
IPC: C07K7/04
Filed: 1983-08-10
Abstract: The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm and an isoelectric point of 3.95+0.15 and a specific aminoacid composition, the N-terminal, if appropriate, carrying an acyl group or an acylglycyl group, processes for its isolation and purification, its use, agents containing this polypeptide, and its cleavage products, their use and agents containing them.