baber/WOPTO huggingface dataset:
Patent IL-85806-A0 (IL)
Title: Apparatus for detachably connecting a tool to a manipulating device
IPC: B23B31/22
Filed: 1988-03-22
Abstract: The invention provides an apparatus for detachably connecting a tool to a manipulating device, e.g. an industrial robot. The apparatus includes a tool holder and a coupling member fastened to the robot. The coupling member has a free frontal surface on which the tool holder rests. A plurality of air channels and electric contacts merge into the free frontal surface in a peripheral region thereof. Four projecting centering pins are provided in the center of the free frontal surface. The tool holder is provided with correspondingly located air channels and electric contacts as well as with a centrally arranged centering disc which is rigid in circumferential direction and axially resilient. The disc has apertures in which the centering pins enter when the tool holder is fixed to the coupling member. Thus, the tool holder is precisely centered and all pneumatic and electric connections are automatically established.
Patent IL-93792-A0 (IL)
Title: Insulin compounds,their preparation and compositions comprising them
IPC: C12P21/04
Filed: 1990-03-19
Abstract: Novel insulin compounds having a desirably protracted insulin action and/or antigenicity are provided. The novel insulin compounds are represented by the formula II:   <IMAGE>    <IMAGE>    <IMAGE>    wherein E individually represents Glu or a neutral amino acid residue which can be coded for by nucleotide sequences, N represents an amino acid residue which can be coded for by nucleotide sequences, T represents Thr or Arg, X represents Thr, Ser, Ala or OH, and Y represents OR or NR1R2, where R, R1 and R2 individually represents hydrogen or lower alkyl, but is not present when X represents OH.
Patent IL-95320-A0 (IL)
Title: 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61P9/00
Filed: 1990-08-09
Abstract: The invention relates to 1-oxa-2-oxo-8-azasprio [4,5]decane derivatives of formula (I), <CHEM>  wherein  X represents an oxygen atom or an NR group,  wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6 cycloalkyl group, or a carbocyclic C6-10 aryl or carbocyclic C6-10 aryl-C1-14 alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4 alkoxy groups; R<1> and R<2> together represent a methylene group or, when X is a NR group, one of R<1> and R<2> additionally represents a hydroxyl group and the other additionally represents a methyl group; R<3> represents a hydrogen atom or a phenyl group optionally substituted by one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy or hydroxyl group; Ph represents a phenyl group unsubstituted or substituted by one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy, hydroxyl or trihalomethyl groups; and  n is 1, 2, 3; and optical isomers and mixtures thereof and all acid addition and quaternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess calcium, uptake-inhibiting, antihypoxic and antianoxic properties and a low toxicity. Thus, they are useful for the treatment of brain damage of various origin.
Patent IL-99755-A0 (IL)
Title: Hydroxymethyl(methylenecyclopentyl)purines and pyrimidines and pharmaceutical compositions containing the same
IPC: C07D473/32
Filed: 1991-10-15
Abstract: Antiviral activity is exhibited by compounds having the formula <CHEM> and its pharmaceutically acceptable salts. v
Patent IL-110228-A0 (IL)
Title: Device for holding and dispensing liquids
IPC: G01F11/02
Filed: 1994-07-06
Abstract: PCT No. PCT/EP94/02149 Sec. 371 Date Dec. 12, 1995 Sec. 102(e) Date Dec. 12, 1995 PCT Filed Jun. 30, 1994 PCT Pub. No. WO95/01924 PCT Pub. Date Jan. 19, 1995A childproof device (1) for holding and dispensing liquids, in particular medicines, that provides precise dosages of liquid, comprising a bottle (2), a cap (5) which is irremovable from the bottleneck (4), said cap being associated with a hollow cylinder (6) extending axially to near the bottle bottom (3) and a reciprocating dispenser comprising a barrel (8) and a plunger (9). The dispenser provides the only means of getting medicine out of the bottle since the cylinder associated with the cap prevents the contents of the bottle from being poured or shaken out. The device is easily assembled and can be stored, sold and used as supplied by the manufacturer.
Patent IL-110994-A0 (IL)
Title: A process for preparing imidazopyridine derivatives
IPC: C07D519/00
Filed: 1994-09-18
Abstract: A novel process for the preparation of imidazopyridines of the general formula <IMAGE> wherein the radicals R1 to R4 have the meaning indicated in the description, is described. In the key step of the process an alkoxyimidate of the formula <IMAGE> is cyclised with aminoacetonitrile and with a 1,3-dicarbonyl compound of the general formula <IMAGE>   The imidazopyridines are useful intermediates for the preparation of angiotensin II antagonists.
Patent IL-112461-A0 (IL)
Title: Preparation of recombinant adeno-associated viruses (aavs) and their use
IPC: C12N15/861
Filed: 1995-01-26
Abstract: PCT No. PCT/FR95/00054 Sec. 371 Date Jul. 25, 1996 Sec. 102(e) Date Jul. 25, 1996 PCT Filed Jan. 18, 1995 PCT Pub. No. WO95/20671 PCT Pub. Date Aug. 3, 1995A novel method for preparing vectors derived from adeno-associated viruses (AAV), cells used therefor, and the use of the resulting vectors, particularly in gene and/or cell therapy, are disclosed.
Patent IL-122832-A0 (IL)
Title: Method for detecting identifying isolating and selectively labelling and targeting TH1 lymphocytes by means of the LAG-3 protein
IPC: A61P31/00
Filed: 1996-07-19
Abstract: The lymphocyte ativation gene (LAG-3) is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. Surface LAG-3 expression correlated with IFN-gamma but not IL-4, production in antigen-stimulated T-cells and it was up-regulated by IL-12 and is preferentially associated with CD4+ T-cells producing Th1-type cytokines. The presence of LAG-3 on the surface of Th1 lymphocytes is used as a marker to detect and identify Th1 lymphocytes and differentiate them from Th2 lymphocytes. Monoclonal antibodies to LAG-3 are used in methods of detecting and isolating Th1 cells as well as methods of diagnosing Th1-mediated disease. The present invention also relates to methods of treating infectious diseases, cancer, and disorders assocated with Th1/Th2 imbalance.
Patent IL-129032-A0 (IL)
Title: A gastric band
IPC: A61F5/00
Filed: 1999-03-17
Abstract: A gastric band of a belt type is presented for attaching around a circumference of a patient's stomach, so as to define the diameter of the stomach opening. The band comprises outer and inner surfaces, wherein the inner surface engages the stomach, and at least the outer surface is formed by an elongated member substantially non-extendable along a longitudinal axis thereof. A through-going opening is made in the elongated member and is located so as to define an end portion of the band having a predetermined length. An opposite end portion of the band is shaped so as to be insertable into the through-going opening for adjusting a desired inner diameter of the band in its closed operating position and fastening the opposite end portion to the outer surface of the band. <IMAGE>
Patent IL-131962-A0 (IL)
Title: Antiviral protease inhibitors
IPC: A61K31/404
Filed: 1998-04-03
Abstract: Compounds of the formula  I :   
wherein: 
A' and A" are independently the same or different group of the formula  II :   
wherein:  R' is H, CH 3 , C(CH 3 ) 2 , -OR a , -N(R a ) 2 , -N(R a )OR a  or -DP  R''' is H or CH 3 ; R a  is H, C 1 -C 3  alkyl;  D is a bond, alkylene, -C(=O)-, -S(O)- or -S(O) 2 - ;  P is an optionally substituted, mono or bicyclic carbo- or heterocycle;  R" is H, any of the sidechains found in the natural amino acids, carboxacetamide, or a group (CH 2 ) n DP;  M is a bond or -C(=O)N(R''')-;  Q is absent, a bond, -CH(OH)- or -CH 2 -;  or R" together with Q , M and R' define an optionally substituted 5 or 6 membered carbo- or heterocyclic ring which is optionally fused with a further 5 or 6 membered carbo- or heterocyclic ring;  with the proviso that R' is -OR a , -N(R a ) 2 , -N(R a )OR a  or -DP, if M is a bond and Q is absent; X is H, OH, OCH 3 ;  Y is H, OH, OCH 3 , but X and Y are not both H;  Z' and Z" are independently -(CH 2 ) m P where P is as defined above;  n and m are independently 0,1 or 2;  and pharmaceutically acceptable salts and prodrugs thereof have utility as aspartyl protease inhibitors of HIV. They can be prepared in a facile two step synthesis from novel 2,5-di-O-benzyl-L-mannaro-1,4:6,3-dilactone intermediates.
Patent IL-133623-A0 (IL)
Title: Antithrombotic agents
IPC: A61K31/41
Filed: 1998-06-26
Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
Patent IL-134930-A0 (IL)
Title: Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing the same
IPC: A61P25/20
Filed: 1998-09-08
Abstract: Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.
Patent IL-145906-A0 (IL)
Title: A device for a pawn automat for bottles and cans
IPC: G07F1/04
Filed: 2000-04-11
Abstract: In a reverse vending machine the feed opening ( 22 ) in the front cover ( 14 ), for bottles and cans, is without a fixed connection to pipework, etc. At the same time, an opening ( 26 ) for emptying remnants is formed in the front cover ( 14 ), in the form of a bowl, which merges at the back side of the front cover into a drain pipe socket ( 28 ) positioned above an upwards open drain channel ( 30 ) in the interior of the machine, without a fixed connection between the drain pipe socket ( 28 ) and the channel ( 30 ). The front cover is possibly lockable and can be opened to the side by means of hinges ( 24 ), whereby the interior of the reverse vending machine is uncovered for inspection, maintenance or repair.
Patent IL-148982-A0 (IL)
Title: Iron fortification system
IPC: A23L2/00
Filed: 2000-03-01
Abstract: An iron-protein hydrolysate complex which may be used to fortify foods and beverages with iron. The complex is formed of ferrous ions chelated to partially hydrolyzed egg white protein. The hydrolyzed egg white protein has a molecular weight in the range of about 500 to about 10,000. The complexes are sufficiently stable as to be suitable for use in sterilized products, such as retorted products. Moreover, despite the stability, the iron in the complexes has substantially the same bioavailability as ferrous sulfate.
Patent IL-157639-A0 (IL)
Title: Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
IPC: C07K14/47
Filed: 2002-02-28
Abstract: A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged liver tissue region of the individual, at least one of the at least two distinct growth factors being an angiogenic factor.
Patent IL-166743-A0 (IL)
Title: Preparation for fixing to a natural piece of toothor to a tooth and corresponding fixing method
IPC: A61K6/083
Filed: 2005-02-08
Abstract: A preparation ( 10, 11,12,13 ) to be fixed to a natural tooth part or tooth, in particular for the replacement of a load-bearing tooth part, is for example a filling for a drilled-out tooth ( 1 ), a crown, bridge or prosthesis to be placed on a tooth stub, or a tooth pin to be fixed in a tooth root for fastening an artificial tooth, a bridge or a prosthesis. The preparation has surface regions which consist of a material with thermoplastic properties. The preparation ( 10, 11, 12,13 ) is designed in a manner such that it has oscillation properties with such low damping losses that for a liquefaction of the material with thermoplastic properties by way of oscillations there are local stress concentrations required, and in a manner such that such stress concentrations only occur in the region of the preparation surface. The preparation is positioned on a suitably prepared natural tooth part in a manner such that the material with the thermoplastic properties is in contact or may be brought into contact with the dentin surface and/or enamel surface. The preparation is then made to mechanically oscillate and is simultaneously pressed against the natural tooth part, whereby the material with the thermoplastic properties is at least partly liquefied and brought into intimate contact with the dentin or enamel surface in a manner such that after solidification it forms a positive fit and/or material fit connection. Teeth restored with such preparations have a high stability and a long life, which in particular is attributed to the fact that the thermoplastic material, in contrast to cements used for the same purpose, shrinks less and has the ability to relieve internal stress by creeping.
Patent IL-195213-A0 (IL)
Title: Protecting users from malicious pop-up advertisements
Filed: 2008-11-11
Abstract: The present invention is a solution for detecting a spoofed command button in a pop-up window. The solution tracks the creation process of a pop-up window, detects the presence of command buttons in the pop-up window, verifies the value labeled on each command button in the pop-up window and determines a follow-up action generated from selecting a command button on the pop-up window.
Patent RO-126028-A0 (RO)
Title: Aerohydrodynamic body with low head resistance and enhanced coandă effect
Inventor: PREOTU OCTAVIAN
IPC: B60V3/06
Filed: 2010-10-08
Abstract: The invention relates to an aerohydrodynamic body with low head resistance and enhanced Coandă effect, meant for air vehicles, as well as marine and river ships achieving low resistance to motion, while interfering with the flow of the fluid (air or water) by reducing turbulence. The body claimed by the invention comprises a central body (1) and a median body (2), supported by some struts (3) maintaining the space between the bodies, thereby forming a channel (a) adapted to the cruising speed of the air or naval vehicle, which transmits the low upstream pressure to the terminal part of the body, where a negative pressure suction area is formed, the fluid stream, previously deflected towards the body by the Coandă effect generated on the divergently curved terminal surface thereof, being sucked by means of the channel (a), the constructive shape thereof allowing the deviation of the fluid stream due to the Coandă effect to overlap the suction caused by the negative pressure area in the terminal part of the body, resulting in the enhancement of the Coandă effect.
Patent RO-135354-A0 (RO)
Title: Method of determining dental erosion
Inventor: BORŞ ANDREA-IZABELLA
IPC: G01B21/30
Filed: 2021-05-27
Abstract: The invention relates to a method for determining erosive lesions occurring in dental enamel. According to the invention, the method comprises a first step of selecting extracted permanent molars and sectioning them with a diamond disk, cleaning the fragments to remove excess and impurities, immersing the fragments in artificial saliva for 12 hours, keeping a reference surface at each enamel fragment, half of the surface of each sample being covered with colored varnish, to compare the change in roughness in the same sample, subjecting the enamel fragments to a cycle of immersion in potentially erosive beverages and, after the end of the cycle, the varnish is removed and the dental enamel roughness is measured for the exposed surface, as compared to the surface protected by the varnish, followed by performing five determinations for each enamel surface using a surfometer and calculating the roughness as an average of the five determinations, while making the difference between the roughness of the exposed surface and the roughness of the reference surface.
Patent AP-2002002549-A0 (AP)
Title: Attenuated microorganisms for the treatment of infection
Inventor: DOUGAN GORDON
IPC: C12N1/21
Filed: 2000-12-22
Abstract: Double mutant salmonella microorganisms help prevent reactivity of the microorganism while maintaining the effectiveness to elicit an immune response. Various specific combinations of mutants are beneficial.
Patent ZW-4294-A1 (ZW)
Title: Heterocyclic derivatives
Inventor: WAYNE MICHAEL GARTH
IPC: A61K31/4409
Filed: 1994-03-28
Abstract: RS 3-Methyl-4-Ä4-(4-pyridyl)piperazin-1-ylÜphenoxybutyric acid and metabolically labile ester or amides thereof, and pharmaceutically acceptable salts thereof useful as an inhibitor of the binding of fibrinogen to glycoprotein IIb/IIIa.
Patent ZW-5989-A1 (ZW)
Title: Heterocyclic compounds
Inventor: STEVEN PAUL BROWN
IPC: C07D333/62
Filed: 1989-04-28
Abstract: The invention concerns novel heterocyclic nitromethane derivatives of the formula 1 as defined hereinafter (and their non-toxic salts) wherein the heterocyclic moiety Q may bear a wide variety of optional substituents, together with pharmaceutical compositions containing them. The nitromethane derivatives are inhibitors of the enzyme aldose reductase and are of value in the treatment of certain complications of diabetes and galactosemia. The invention further concerns novel processes for the manufacture and use of said inhibitors.
Patent LU-86960-A1 (LU)
Inventor: MAIGNAN JEAN
IPC: C07D239/50
Filed: 1987-07-31
Abstract: A process for the preparation of 6-piperidino-2,4-diaminopyrimidine 3-oxide, characterised in that, in a first stage, at least one of the two amine functional groups of a compound of formula (I): 
<IMAGE>
 in which X denotes halogen or an OH group, is protected by an addition reaction of an isocyanate of formula:
 R-N=C=O
 in which R denotes an alkyl group, to one of the amine groups of the compound of formula (I), in that the resulting urea derivative is then oxidised to convert the compound into the corresponding N-oxide, the N-oxide then being reacted with piperidine and then subjected to a reaction for removing the protective group(s) by treatment with an organic or inorganic base, and the new intermediate compounds.
Patent MA-27800-A1 (MA)
Inventor: CASTRO MYLENE
IPC: A21C9/04
Filed: 2005-11-09
Abstract: Production of food products in sheet form by making a dough, optionally resting the dough, cooking sheets of the dough on one side and stacking the sheets before cooling and packaging comprises forming a moisture barrier on at least one side of the cooked sheets before stacking. Independent claims are also included for: (1) food product in sheet form produced as above with a film of powdered food product on at least one side; (2) food product in sheet form produced as above with a film of fatty food product on at least one side; (3) apparatus for carrying out the above process, comprising a dough preparation station (1), one or more cooking stations (3), a distributor (2) for delivering sheets of the dough to the cooking station, a stacking station (5), and a dusting station (4) or drying tunnel between the cooking station and the stacking station.
Patent MA-38885-A1 (MA)
Title: Dérivés d'éthynyle modulateurs allosteriques positifs (pam) du recepteur metabotropique du glutamate 4 (mglu4)
Inventor: VIEIRA ERIC
IPC: C07D513/04
Filed: 2014-09-22
Abstract: La présente invention porte sur des composés de formule i dans laquelle y représente n ou c-r1' ; g représente un noyau aromatique ou hétéroaromatique à 5 ou 6 chaînons contenant 0, 1, 2 ou 3 hétéroatomes, choisi dans le groupe constitué par les noyaux phényle, pyridinyle à différentes positions de n, imidazolyle, pyrazinyle, pyrimidinyle, thiophényle, thiazolyle, pyrazolyle ou thiadiazolyle, qui sont éventuellement substitués par 1, 2 ou 3 substituants, choisis dans le groupe constitué par les substituants halogéno, alkyle inférieur, alcoxy inférieur, alcoxy inférieur substitué par halogène ou nrr' ; r et r' sont chacun indépendamment de l'autre l'atome d'hydrogène ou un groupe alkyle inférieur ou ils peuvent former conjointement avec l'atome n auquel ils sont attachés un groupe hétérocyclique saturé à cinq ou six chaînons qui peut contenir un atome d'oxygène ou groupe nh ou n-(alkyle inférieur) supplémentaire ; r1 représente l'atome d'hydrogène, un atome d'halogène ou un groupe alkyle inférieur substitué par halogène ; r1' représente l'atome d'hydrogène, un atome d'halogène ou un groupe alkyle inférieur substitué par halogène ; r2 représente l'atome d'hydrogène ou un groupe alkyle inférieur, alcoxyalkyle inférieur, cycloalkyle ou hétérocycloalkyle ; ou r2 peut former conjointement avec l'atome de carbone le plus proche dans un groupe g un groupe (ia), a représentant -ch2-, -ch2ch2 ou -c(ch3)2- ; r3 est un groupe phényle ou pyridinyle, l'atome n dans le groupe pyridinyle pouvant être en différentes positions ; ou sur un sel ou sel d'addition d'acide pharmaceutiquement acceptable de ceux-ci, sur un mélange racémique de ceux-ci ou sur son énantiomère et/ou isomère optique et/ou stéréoisomère correspondant. Il a été trouvé de manière inattendue que les composés de formule générale i sont des modulateurs allostériques positifs (pam) du récepteur métabotropique du glutamate 4 (mglu4), utiles pour le traitement de la maladie de parkinson, de l'anxiété, de vomissements, d'un trouble obsessionnel-compulsif, de l'autisme, pour la neuroprotection et pour le traitement d'un cancer, d'une dépression et du diabète de type 2.
Patent MA-39438-A1 (MA)
Title: Banderole dotée de partie amovible intégrée
Inventor: RICK JEAN-LUC
IPC: C09J7/29
Filed: 2015-04-07
Abstract: La présente invention porte sur une banderole (1) ayant une structure multicouche. La structure multicouche comprend une couche d'impression (3), une première couche de support (5), une première couche adhésive (7), une seconde couche de support (9) et une seconde couche adhésive (11), ce par quoi la première couche adhésive (7) produit une adhérence pouvant être relâchée au moins sur une partie de la zone d'interface entre la première couche adhésive (7) et la seconde couche de support (9). A l'intérieur de la zone d'adhérence pouvant être relâchée, une partie amovible (13, 13') constituée par une partie de la couche d'impression (3), de la première couche de support (5) et de la première couche adhésive (7) est définie en taille et en forme par une ligne de déchirure continue (15) qui s'étend à travers la totalité de la couche d'impression (3), de la première couche de support (5) et de la première couche adhésive (7). L'adhérence pouvant être relâchée et la ligne de déchirure continue (15) facilitent le retrait de la partie amovible.
Patent MA-45504-A1 (MA)
Title: Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives
Inventor: STUART MONIC
IPC: A61P35/00
Filed: 2013-11-15
Abstract: La présente invention concerne des procédés pour réduire la prolifération de cellules progénitrices néoplasiques et soulager des symptômes associés chez des individus diagnostiqués avec ou suspectés d'avoir des troubles myéloprolifératifs, tels que la thrombocytémie essentielle (te). La présente invention concerne en outre des procédés d'utilisation d'inhibiteurs de télomérase pour maintenir les numérations plaquettaires sanguines dans des plages relativement normales dans le sang d'individus diagnostiqués avec ou suspectés d'avoir des troubles myéloprolifératifs, tels que te.