baber/WOPTO huggingface dataset:
Patent WO-2021014019-A1 (WO)
Title: Saponin derivatives with improved therapeutic window
Inventor: POSTEL RUBEN
IPC: A61K31/7034
Filed: 2020-07-24
Abstract: The invention relates to a saponin derivative based on a saponin comprising a triterpene aglycone and a first saccharide chain and/or a second saccharide chain, and comprising: an aglycone core structure comprising an aldehyde group which has been derivatised; and/or the first saccharide chain wherein the first saccharide chain comprises a carboxyl group, which has been derivatised; and/or the second saccharide chain wherein the second saccharide chain comprises at least one acetoxy group which has been derivatised. The invention also relates to a first pharmaceutical composition comprising the saponin derivative of the invention. In addition, the invention relates to a pharmaceutical combination comprising the first pharmaceutical composition of the invention and a second pharmaceutical composition comprising any one or more of an antibody-toxin conjugate, a receptor-ligand – toxin conjugate, an antibody-drug conjugate, a receptor-ligand – drug conjugate, an antibody-oligonucleotide conjugate or a receptor-ligand – oligonucleotide conjugate. The invention also relates to the first pharmaceutical composition or the pharmaceutical combination of the invention, for use as a medicament, or use in the treatment or prophylaxis of a cancer, an infectious disease, viral infection, hypercholesterolemia, primary hyperoxaluria, haemophilia A, haemophilia B, alpha-1 antitrypsin related liver disease, acute hepatic porphyria, transthyretin-mediated amyloidosis, or an auto-immune disease. Furthermore, the invention relates to an in vitro or ex vivo method for transferring a molecule from outside a cell to inside said cell, comprising contacting said cell with the molecule and with a saponin derivative of the invention.
Patent WO-2021032552-A1 (WO)
Title: Method for manufacturing a timepiece bearing
Inventor: CARRENO WILLIAM
IPC: G04B31/06
Filed: 2020-08-12
Abstract: Disclosed is a method for manufacturing a pivot bearing (1) for the pivoting of a timepiece component (2), in particular a pivot stone, characterised in that it comprises the following steps: - Boring (E1) a hole (10a) in a bearing (1) blank (1a) along an axis (A1) intended for the pivoting of a timepiece component (2), this hole (10a) forming a start point (13a) of a first pivot zone (13) of the bearing (1), then - Laser engraving (E2), in the blank (1a), in particular using a femtosecond laser, a second clearance zone (14) of the bearing (1), juxtaposed with the start point (13a) of a first pivot zone (13), this second clearance zone (14) of the bearing (1) opening at a first face (11a) of the bearing (1) blank (1a), then - Removing material by means of wear (E3), in particular by olive-cutting, at the start point (13a) of a first pivot zone (13) of the bearing (1) and a boundary zone (14a) between the start point (13a) of a first pivot zone (13) of the bearing (1) and the second clearance zone (14) of the bearing (1) in order to form a first pivot zone (13) and a second clearance zone (14) of the bearing (1) that are juxtaposed, being connected to each other by a rounded connection.
Patent WO-2021037968-A1 (WO)
Title: Partial vehicle diagnostics
Inventor: PALAI DIBYENDU
IPC: H04L29/08
Filed: 2020-08-27
Abstract: The present disclosure relates to a control system (2) for a vehicle. The control system is configured to receive a request to initiate a diagnostic conversation, and attempt to initiate the requested diagnostic conversation while the vehicle is in a sleep state. The control system is further configured to determine one or more target participants that are required for participation in a requested diagnostic conversation, to determine an on-board energy status of the vehicle, and to energise the target participants without energising the entire vehicle and initiate the requested diagnostic conversation in dependence on the onboard energy status of the vehicle being sufficient to conduct the requested diagnostic conversation.
Patent WO-2021048429-A1 (WO)
Title: A modular system for monitoring and controlling the homeostasis in cavities, and a method for generating a volume of fluid in a cavity
Inventor: DÍAZ CAMBRONERO ÓSCAR
IPC: A61M13/00
Filed: 2020-09-12
Abstract: A modular system (1) for the monitoring of the homeostasis in cavities for endoscopic procedures comprises: - an intracavity device (2) with an insertable portion having on its outer surface a sensor module (3) which comprises at least one sensor of temperature, humidity or both; - a variable output humidifier and heating module (12); - a fluid insufflation module (7); - a second group of sensors comprising at least a volume sensor (16), a pressure sensor (17) or both, wherein the fluid flows through the volume and/or pressure sensors; and - a monitoring and control of the homeostasis module (4) connected to the sensor module and to the second group of sensors and which comprises a processing unit (6). The method comprises insufflating fluid into the cavity, to maintain a working volume and maintain the homeostasis of the cavity in a continuous manner, in particular the distensibility, temperature and humidity.
Patent WO-2021139912-A1 (WO)
Title: Verfahren zur steuerung der inbetriebnahme eines elektrisch ansteuerbaren aktors in einem kraftfahrzeug und elektronisches steuergerät zur durchführung dieses verfahrens
Inventor: BRAEUCHLE GOETZ
IPC: B60T17/22
Filed: 2020-11-05
Abstract: Die Erfindung betrifft ein Verfahren zur Steuerung der Inbetriebnahme eines elektrisch ansteuerbaren Aktors in einem Kraftfahrzeug (10), insbesondere zum Zweck einer Überprüfung seiner Funktionstüchtigkeit sowie ein elektronisches Steuergerät (16) zur Durchführung dieses Verfahrens. Moderne Kraftfahrzeuge sind ausgestattet mit einem elektrisch ansteuerbaren ersten Aktor (12) und einem elektrisch ansteuerbaren und redundant zum ersten Aktor (12) vorhandenen zweiten Aktor (14), sowie mit wenigstens einem elektronischen Steuergerät (16) zur elektrischen Ansteuerung der Aktoren (12, 14). Erfindungsgemäß erfolgt eine Inbetriebnahme des zweiten Aktors (14) durch das elektronische Steuergerät (16) in Abhängigkeit einer Signalinformation, welche ein in einem Fahrgastraum (26) des Kraftfahrzeugs (10) vorherrschendes Geräuschniveau repräsentiert.
Patent WO-2021110595-A1 (WO)
Inventor: OGIEN JONAS
IPC: G01N21/45
Filed: 2020-11-30
Abstract: The present description relates to a device (200) for line-scanning optical-coherence-tomography microscopy. The device comprises an interferometric microscope (201) comprising a reference arm, an object arm configured to receive an object (10), a beam splitter (204) coupling said object and reference arms to a light source (210) and to a detector (222), and a first microscope objective (202) arranged on said object arm. The device further comprises a one-dimensional confocal spatial filtering device configured to interact with the light source in order to illuminate the object along a focal line located in an object space of the first microscope objective, and a device (235, 237) for scanning the focal line in one direction, which device is arranged on the object arm upstream of the first microscope objective and configured to scan the focal line in a lateral direction (y) substantially perpendicular to an optical axis (z) of said first microscope objective.
Patent WO-2021122116-A1 (WO)
Inventor: LIGAJ MARTA
IPC: B32B9/00
Filed: 2020-12-07
Abstract: The invention relates to a packaging material having antimicrobial properties in form of a layered composite. The packaging material has a support layer with an outer surface and an inner surface intended for contacting the package contents. At least a part of the inner surface of the support layer is provided with a nanocomposite coating comprising zerovalent iron nanoparticles dispersed in a polymer matrix. The invention further relates to a method for producing a packaging material and to use of a nanocomposite containing zerovalent iron nanoparticles dispersed in a polymer matrix for producing a coating having antimicrobial properties on an inner surface of a support layer of the packaging material.
Patent WO-2021122483-A1 (WO)
Title: Procédé de découpe en continu de bandes métalliques
Inventor: FOLKE THOMAS
IPC: B23K26/352
Filed: 2020-12-14
Abstract: L'invention concerne un procédé de découpe d'aciers à haute résistance (3), dans lequel procédé, dans une première étape avant l'étape de découpe, la résistance de l'acier à haute résistance (3) est réduite de manière permanente au moyen d'un traitement thermique local (7) de la future ligne de coupe (9), et l'étape de coupe (4) a lieu par découpe le long de la ligne de coupe (9) de résistance réduite de manière permanente.
Patent WO-2021122862-A1 (WO)
Title: Systèmes et procédés d'atténuation d'aberration chromatique
Inventor: REN YAN
IPC: H01J37/26
Filed: 2020-12-16
Abstract: La présente invention concerne un procédé de réduction d'aberration comprenant la séparation (830) des particules chargées d'un faisceau (811) sur la base de l'énergie (810) des particules chargées pour former des petits faisceaux (812-814), chaque petit faisceau étant conçu pour contenir les particules chargées à un niveau d'énergie central; et la déviation (950) des petits faisceaux de manière à ce que les petits faisceaux ayant différents niveaux d^'énergie centrale soient déviés différemment. Un correcteur d'aberration comprend un élément dispersant (830) (éventuellement 820) conçu pour amener les parties constituantes d'un faisceau (811) (p.ex. un faisceau de particules chargées) à s'étaler sur la base de l'énergie (810); un réseau d'ouverture (840) conçu pour former des petits faisceaux (812-814) à partir du faisceau étalé; et un réseau déflecteur (950) conçu pour dévier différemment les petits faisceaux sur la base des niveaux d'énergie centrale de particules qui constituent les petits faisceaux.
Patent WO-2021170290-A1 (WO)
Inventor: SETZ CHRISTIAN
IPC: A61P31/14
Filed: 2021-02-26
Abstract: The present application relates to small molecule inhibitors of human deubiquitinases for use in the prevention or treatment of a coronaviral infection. It relates in particular to small molecule inhibitors of USP7 and USP47. Pharmaceutical compositions, respective advantageous formulation techniques and a method of treatment are disclosed.
Patent WO-2021175695-A1 (WO)
Inventor: BORKAR RAKESH RAMESH
IPC: H02J3/32
Filed: 2021-02-25
Abstract: A vessel power distribution system for controlling power supply to and from a propulsion system (10, 20) of a vessel, the propulsion system comprising at least two drive shafts, each having a propeller and each propulsion system comprising a motor/generator unit (34) adapted to receive power from a prime mover (31) of the vessel and supply it to the drive shaft (32), or to receive power from an alternative energy source and supply power to the shaft. The power distribution system further comprises a converter unit (39) comprising for the first drive shaft, two shaft generator converters and a first energy storage unit coupled to a first DC bus; and for the second drive shaft, two shaft generator converters and a second energy storage unit coupled to a second DC bus; each of the DC buses being coupled together by a switching device. The switching device comprises two pairs of controllable semiconductor devices (61) in parallel with diodes (62) arranged such that current flow between the first and second DC buses (44, 45) is inhibited when at least one of the semiconductor devices is non-conducting; whereby power from one prime mover may be switched from a first drive shaft (32) to a second drive shaft (32), or vice versa; or power from an alternative energy source may be directed to one of the first and second drive shafts.
Patent WO-2021180764-A1 (WO)
Title: Chair
Inventor: RINGGENBERG MARIANO
IPC: A47C3/025
Filed: 2021-03-10
Abstract: The invention is directed to a chair comprising a seat carrier (1) and a seat, wherein the seat carrier (1) is equipped with a support face part (2), a movement mechanics (10) coupled to the support face part (2) and a drive unit (20) coupled to the movement mechanics (10). The seat is mounted to the support face part (2) of the seat carrier (1). The movement mechanics (10) of the seat carrier (1) is configured to repeatedly tilt the support face part (2), and the drive unit (20) is configured to induce the movement mechanics (10) to repeatedly tilt the support face part (2).
Patent WO-2021190971-A1 (WO)
Title: Source de lumière et procédé de fonctionnement d'une source de lumière
Inventor: HEROLD MARCO
IPC: B05D3/06
Filed: 2021-03-15
Abstract: L'invention se rapporte à une source de lumière (1) comprenant au moins un composant électroluminescent (11, 13, 15), en particulier un composant émettant de la lumière ultraviolette et/ou un composant semi-conducteur, et un système de conduites (103) à travers lequel un fluide de refroidissement peut s'écouler dans un sens d'écoulement (F) afin de réguler la température du ou des composants électroluminescents, et un premier et un second capteur de pression de fluide de refroidissement (21, 22) qui sont disposés dans le système de conduites (103) les uns derrière les autres dans le sens d'écoulement (F) ; et une unité électronique (3) connectée au premier et au second capteur de pression de fluide de refroidissement (21, 22), laquelle unité électronique est conçue pour déterminer au moins une valeur de diagnostic, une valeur de commande en boucle ouverte et/ou une valeur de commande en boucle fermée sur la base des pressions (p1, p2) détectées par le premier capteur de pression de fluide de refroidissement (21) et par le second capteur de pression de fluide de refroidissement (22).
Patent WO-2021198180-A1 (WO)
Title: Système de perforation avec revêtement de tubage intégré et revêtement de protection contre l'érosion
Inventor: LOEHKEN JOERN
IPC: F42B1/028
Filed: 2021-03-29
Abstract: Revêtement de charge creuse pouvant comprendre une partie sommet et une partie de jupe s'étendant à partir de la partie sommet. La partie de jupe peut comprendre un corps relié à la partie sommet, un périmètre espacé de la partie de sommet, et une couche de carbure s'étendant entre le périmètre et la partie de sommet et espacée de ceux-ci. Une charge creuse pour créer un trou de perforation dans un tubage de puits de forage peut comprendre un revêtement de charge creuse ayant au moins un matériau ayant une dureté qui est supérieure à une dureté correspondante du tubage de puits de forage. Le ou les matériaux sont configurés pour se lier à une surface externe et/ou une surface interne du trou de perforation lors de la détonation de la charge creuse et de la pénétration du tubage par un jet de perforation.
Patent WO-2021239325-A1 (WO)
Inventor: FRANCKE JÜRGEN
IPC: G01D11/26
Filed: 2021-04-16
Abstract: Die Erfindung betrifft ein Sensormodul (1) für ein Schienenfahrzeug (7). Es umfasst ein kastenförmiges Modulgehäuse (2) mit einer eine Frontöffnung (4) aufweisenden Gehäusewand (3). Ferner umfasst es ein oder mehrere im Modulgehäuse (2) angeordnete Umfeldsensoren (6) zur Erfassung von durch die Frontöffnung (4) wahrnehmbaren Umfelddaten. Außerdem umfasst es eine oder mehrere die Frontöffnung (4) verschließende Frontfenster (5) mit jeweils einer Fensterscheibe (51). Hierdurch kann die Integration von Umfeldsensoren (6) in Schienenfahrzeuge (7), insbesondere für den Hochgeschwindigkeitsbetrieb, optimiert werden. Die Erfindung betrifft auch ein Schienenfahrzeug (7) mit einem solchen Sensormodul (1).
Patent WO-2021224275-A1 (WO)
Title: Baugruppe für ein fahrzeug
Inventor: GÜNTHER ALEXANDER
IPC: B60K35/00
Filed: 2021-05-04
Abstract: Beschrieben ist eine Baugruppe (1) für ein Fahrzeug umfassend einen Querträger (2), vorgesehen zum Anschluss an zwei aneinander bezüglich der x-z- Ebene des Fahrzeuges gegenüberliegende Säulen, eine an den Querträger (2) angeschlossene und in radialer Richtung von diesem abragende, zwei in y-Richtung voneinander beabstandete Halter (4, 4.1) umfassende Halterung (3) mit endseitigen Anschlussmitteln (17, 17.1, 18) und ein an die Anschlussmittel (17, 17.1, 18) der Halterung (3) mit Abstand zu seinem oberen Abschluss angeschlossenes tafelförmiges Instrument, das derart gehalten ist, dass seine Bedienoberfläche in x-Richtung in den Fahrgastraum des Fahrzeuges weist. Die beiden Halter (4, 4.1) sind als Tragwerkhalter mit jeweils einem oberen Gurt (8) und einem unteren Gurt (9) ausgeführt, welche beiden Gurte (8, 9) jeweils zwei winklig aneinander grenzende Schenkel (12, 13, 12.1, 13.1) aufweisen, von denen einer in der y-z-Ebene und der andere in der x-y- Ebene liegt, und geneigt zueinander angeordnet sind, damit diese instrumentenanschlussseitig einen größeren Abstand voneinander aufweisen als an ihrem zum Querträger (2) weisenden Ende. Zumindest einer der beiden Gurte (8, 9) weist zwischen seinen beiden Anbindungspunkten zumindest eine durch seine Geometrie bereitgestellte Sollknickstelle S 1 -S 3  auf, an der bei einer Beanspruchung (x-Richtung) dieser Gurt (8, 9) in z- und/oder in y- Richtung einknickt.
Patent WO-2021228938-A1 (WO)
Inventor: GIRARD ARNAUD
IPC: G04B19/28
Filed: 2021-05-12
Abstract: The present invention relates to a watch case (1) comprising at least one middle (2), a concentric rotating element (8) mounted on the middle (2), being in communication with the interior of the watch case (1) and arranged so as to be able to be moved in rotation in a transverse plane of the watch case (1), and a sealing device arranged to seal the watch case (1), at least between the middle (2), the rotating element (8) and the interior of the watch case (1). According to the invention, said sealing device comprises at least a first concentric ring (14) that is as one with the rotating element (8) and a second concentric ring (16) that is as one with the middle (2), said first ring (14) and second ring (16) being positioned with respect to one another so as to respectively have a first face (14a) and a second face (16a) in contact with one another, said first face (14a) and second face (16a) respectively having a first contact surface and a second contact surface, these being in contact with one another and arranged so as to form sealing surfaces that establish a seal between said first ring (14) and second ring (16) while allowing these rings to slide with respect to one another.
Patent WO-2021239738-A1 (WO)
Title: Apparatus and method for processing plant material
Inventor: SCREMIN JERONIMO
IPC: A24B1/00
Filed: 2021-05-25
Abstract: A method and apparatus are provided for processing plant material to remove leaves from a plant stalk. The apparatus comprises a conveyor for transporting a plant with leaves hanging down from the stalk; and a defoliator mechanism having two opposing surfaces, the opposing surfaces being movable between (i) a disengaged position for receiving leaves hanging down from the conveyor, and (ii) an engaged position in which the opposing surfaces are configured to grip leaves received by the defoliator mechanism; wherein the opposed surfaces act in the engaged position to apply a force on the gripped leaves to separate them from the stalk.
Patent WO-2022253423-A1 (WO)
Inventor: GERLACH DANIELA
IPC: C07F7/12
Filed: 2021-06-02
Abstract: La présente invention concerne un procédé de préparation de triméthylchlorosilane (M3) et de méthyltrichlorosilane (M1) par dismutation du diméthyldichlorosilane (M2) en présence d'un catalyseur Al2O3 qui, avant la dismutation, est activé avec du chlorosilane de formule (I), RxSiCl4-x, les radicaux R étant indépendamment sélectionnés dans le groupe constitué par (i) un hydrogène et (ii) un radical alkyle en C1-C5, et l'indice x prend les valeurs 1, 2 ou 3, le diméthyldichlorosilane (M2) étant utilisé sous la forme d'un mélange de silane contenant au moins 80 % en poids de diméthyldichlorosilane (M2), la différence par rapport à 100 % comprenant M1 et M3.
Patent WO-2022033877-A1 (WO)
Title: Two step carbonation hardening of hydraulic cement based concrete
Inventor: ZAJAC MACIEJ
IPC: C04B28/04
Filed: 2021-07-28
Abstract: HZ 8301 EP Abstract Method for manufacturing concrete parts comprising the steps: - providing a hydraulic cement and aggregate - mixing the cement and aggregate with water to provide a fresh concrete - introducing CO2 into the fresh concrete in an amount resulting in a carbonation degree of more than 0.5 wt.-% and less than 5 wt.-% of the total carbonatable Ca and Mg phases which are calculated as 0.785 × (CaO - 0.56 CaCO3 - 0.7 SO3 ) + 1.091 × (MgO - 0.479 MgCO3) for a first carbonation step - curing the fresh concrete until at least 15 wt.-% of the calcium aluminates are hydrated to provide a green concrete part - subjecting the green concrete part to CO2 in an amount resulting in a carbonation degree of more than 10 wt.-% of the total carbonatable Ca and Mg phases which are calculated as 0.785 × (CaO - 0.56 CaCO3 - 0.7 SO3 ) + 1.091 × (MgO - 0.479 MgCO3) for a final carbonation step, and - storing the part for 0.5 hours to 28 days for further hydration of not-yet carbonated, not-yet hydrated cement to provide the concrete part. and concrete parts obtainable with the method.
Patent WO-2022053529-A1 (WO)
Title: Piles for self-closing flood barrier
Inventor: FEMONT ANTHONY
IPC: E04H9/14
Filed: 2021-09-08
Abstract: A pile mechanism to support water barrier elements in a self-closing flood barrier is described. The pile mechanism comprises a pile (1) that is arranged substantially beneath ground level when the water level is below the ground level, and that is automatically positioned above the ground level when the water level rises above the ground level. In some embodiments, the pile mechanism comprises a central float (12) that is suited to cause the pile (1) to rise at a water level that is higher than the ground level, a cover element (11) suited to provide a water-tight seal between the pile and at least one water barrier element of the self-closing flood barrier, and a well (2) having at least one flotation compartment (26) from which the pile (1) rises by means of the central float (12) positioned in the flotation compartment (26).
Patent WO-2022063725-A1 (WO)
Inventor: ROL BAPTISTE
IPC: G01R31/42
Filed: 2021-09-20
Abstract: A method for detecting a short circuit in an H-bridge electronic circuit (1), comprising the following steps: - activating a current source (17) on a first test branch; - taking a first potential measurement of one of the output terminals (6); - if the first potential measurement is substantially different from the potential of the supply terminal (3) to which the first test branch is connected, activating a current source (16) on a second, diametrically opposite test branch; - taking a second potential measurement of each output terminal (6, 7); - signalling the detection of a localised short-circuit on the output terminal whose potential resulting from the second potential measurement is closest to the potential resulting from the first potential measurement.
Patent WO-2022090281-A1 (WO)
Inventor: SESTIGIANI LUCA
IPC: F16B5/07
Filed: 2021-10-27
Abstract: Die Erfindung betrifft ein Verfahren zum Verbinden von mindestens zwei Holzbaupaneele (400, 401) zur akustischen und/oder thermischen Isolierung. Erfindungsgemäß wird in einem ersten Schritt eine Metallplatte oder ein Metallstreifen (100) mit einer Dicke gleich oder weniger als 1,5 mm mit Zähnen, die der Oberfläche des mindestens einen Holzpaneels (400) zugewandt sind, in einer Richtung im Wesentlichen senkrecht zur Oberfläche der Metallplatte oder des Metallstreifens angeordnet, -Anbringen eines isolierenden Elements (410, ) auf der zweiten Oberfläche der Holzbaupaneels mit Zähnen, -Anbringen einer zweiten Metallplatte oder Metallstreifens (200) mit einer Dicke von 1,5 mm oder weniger auf dem (isolierenden Elements (410), -Anbringen eines dritten Elements einer Holzbaupaneel (400, 401) auf der zweiten Oberfläche der zweiten Metallplatte oder des Metallstreifens (200) mit Zähnen, -Einführung der Schrauben durch mindestens ein Element (400) und mindestens eine Platte und dass beim Einführen der Schrauben diese Schrauben (500) die Metallplatte oder den Metallstreifen (100, 200, 300) durchbohrt.