Patent GB-622274-A (GB)
Title: Improvements in or relating to surgical sutures
IPC: A61L17/08
Filed: 1944-10-20
Abstract: In the production of a surgical suture, a h moglobin solution may be introduced as part of a rayon spinning solution, or as part of the setting solution.  Or a suture may consist entirely or largely of blood constituents, consisting of h moglobin, and cell wall tissue reduced to a state of dissolution.  Thus, an acid salt such as sodium sulphide may be added to produce a solution of suitable viscosity, which may be extruded into a 15-20 per cent caustic soda solution, the filaments produced being washed with 5-10 per cent sulphuric acid and tanned with hydroquinone or 2-5 per cent formalin (40 per cent solution of formaldehyde).  25 per cent glucose may be added to the treatment baths.  The h moglobin solution may be formed by washing blood cells, which may be animal or human, in saline solution, centrifuging, breaking by washing with an ether-alcohol solution, centrifuging, filtering the liquid, dialysing, filtering, and, if desired, removing the ether by vacuum.  A 15 per cent h moglobin solution remains. Alternatively, the cell walls may be broken by freezing at -75 DEG  to -85 DEG  F. before centrifuging the ether solution.ALSO:A h moglobin solution for use in the production of surgical sutures is prepared by washing blood cells, which may be animal or human, in saline solution, centrifuging, breaking by washing with an ether-alcohol solution, centrifuging, filtering the liquid, dialyzing, filtering, and, if desired, removing the ether by vacuum.  A 15 per cent h moglobin solution remains. Alternatively, the cell walls may be broken by freezing at - 75 DEG  to - 85 DEG  F. before centrifuging the ether solution.ALSO:A surgical suture contains h moglobin which has been released from red blood corpuscles.  Thus, an organic suture, e.g. catgut, linen, silk, cotton, synthetic organic material, may be impregnated with h moglobin solution, which is defined as a liquid comprising the liquid normally contained in the red corpuscles and which may be prepared by breaking them up, and filtering.  A certain amount of the cellular structure may also be present in dissolved form, as may be serum or plasma.  The sutures may be preserved dry, in blood, or in vacuo, or used wet. The h moglobin may be present as oxyh moglobin, or meth moglobin, and the solution may be formed by washing blood cells, which may be animal or human, in saline solution, centrifuging, breaking by washing with an ether-alcohol solution, stirring, centrifuging, filtering the liquid, dialyzing, filtering, and, if desired, removing the ether by vacuum.  A 15 per cent h moglobin solution remains.  Alternatively, the cell walls may be broken by freezing at -75 DEG  to -85 DEG F. before centrifuging the ether solution.  The h moglobin solution may alternatively be introduced as a part of a rayon spinning solution, or as part of the setting solution.  Finally, the suture may consist entirely or largely of blood constituents, consisting of h moglobin, and cell wall tissue reduced to a state of dissolution.  Thus, an acid salt, e.g. sodium sulphide, may be added to produce a solution of suitable viscosity, which may be extended into a 15-20 per cent caustic soda solution, the filaments produced being washed with 5-10 per cent sulphuric acid and tanned with hydroquinone or 2-5 per cent formalin (40 per cent solution of formaldehyde), 25 per cent glucose may be added to the treatment baths.