baber/WOPTO huggingface dataset:
Patent DO-P2006000203-A (DO)
Title: Derivados de fenil-1,2,4-oxadiazolona, procesos para su preparación y su uso como compuestos farmacéuticos
Inventor: URMANN MATTHIAS
Filed: 2006-09-27
Abstract: Derivados de fenil-1,2,4-oxadiazolona, procesos para su preparacion y su use como compuestos farmaceuticos La invención se refiere a derivados de fenil-1,2,4-oxadiazolona en todas sus formas estereoisomericas y mezclas en cualquier relation, y sus sales fisiologicamente aceptables y formas tautomericas que muestran actividad agonista de PPARdelta. Lo que se describe son compuestos de la formula I, Donde los radicales son como se han definido, y sus sales fisiológicamente aceptables y procesos para su preparacion. Los compuestos son adecuados para el tratamiento y/o prevention de trastornos de metabolismo de acidos grasos y trastornos de utilization de la glucosa asi como de trastornos en los que esta implicada la resistencia a la insulina y la desmielinización y otros trastornos neurodegenerativos del sistema nervioso central y periferico.
Patent EC-SP11011126-A (EC)
Title: Anticuerpos anti-igf
Inventor: BORGES ERIC
IPC: A61K33/243
Filed: 2011-06-13
Abstract: Moléculas de anticuerpos, en particular anticuerpos completamente de ser humano que se unen a IGF-1 de ser humano y que tienen reactividad cruzada con IGF-2 tal que se impide la unión de IGF-1 e IGF-2 al receptor de IGF-1 y se inhibe la transmisión de señales mediada por el receptor de IGF-1. Los anticuerpos no se unen a la insulina y de este modo no afectan a las propiedades mitogénicas de la insulina que son mediadas por su enlace a los receptores de la insulina. Los anticuerpos son útiles para el tratamiento de enfermedades hiperproliferativas, en particular el cáncer.
Patent EE-200100491-A (EE)
Inventor: OWEN SIMON NEIL
IPC: A61P25/22
Filed: 2000-03-16
Abstract: The present invention relates to compounds of the formula (I):wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis and postherpetic neuralgia.
Patent GB-189702536-A (GB)
Title: Improvements in or relating to Galvanometers.
Inventor: BROWN FREDERICK
Filed: 1897-01-30
Granted: 1897-12-04
Abstract: 2536. Brown, F. Jan. 30. Casings for voltmeters and other galvanometers are con structed as shown in section. The instrument is screwed to the back of a rectangular or other box c, closed at the top and sides, but open in front and below; the top carries the insulated terminals m. The box is secured by screws d<7> on a base d<2>, and against a sheet of transparent material g in a recessed front d thereon, the upper part of the front being open to show the pointer and scale g<2>.
Patent GB-189703173-A (GB)
Title: Improvements in Means for Securing Bamboo Parts or other like Bodies together.
Inventor: NEEDHAM FREDERICK WILLIAM
Filed: 1897-02-06
Granted: 1898-02-05
Abstract: 3173. Needham, F. W. Feb. 6. Furniture, bamboo and like.-Means are described for connecting bamboo rods or like parts in the manufacture of bedsteads, furniture, &c. Reference is made to Specification No. 2383, A.D. 1888. Figs. 1 and 2 show a method of uniting a vertical post or pillar 7 to a horizontal rail. To the upright 7 is secured a metal sleeve 9, which, along with the said upright, is perforated to receive the rail 8, on which is fitted a metal sleeve 10. The two sleeves 9 and 10 are soldered together round the opening 11 in the former. Fig. 3 shows the method of uniting two rails 8 and 8<a> with an upright 7, and Figs. 4 and 5 a method of uniting four rails to an upright, one rail passing through the upright.
Patent GB-189703300-A (GB)
Title: Improved Automatic Apparatus for Extinguishing the Flame in Hydrocarbon Oil Burners.
Inventor: SWIFT HENRY
Filed: 1897-02-08
Granted: 1897-04-10
Abstract: 3300. Swift, H. Feb. 8. Extinguishing oil lamps.-The extinguishing flap or hood a is mounted by the split end h of the arm c upon a squared portion f of the wick-raising spindle. When the wick is raised or lowered, the extinguisher is simultaneously removed from or projected over the wick-tube. The invention may be adapted to duplex and other flat-flame burners.
Patent GB-189706042-A (GB)
Title: Improvements in Apparatus for Printing Photographs from Negatives.
Inventor: SHAW CHARLES
Filed: 1897-03-08
Granted: 1898-03-08
Abstract: 6042. Shaw, C. March 8. Printing; vignetting.-Relates to a printing-frame consisting of a board or pad of papier mÔchÚ, cardboard, or the like, divided into two parts which are hinged together at K", Fig. 3. The sensitive paper and negative are clamped on the short piece by an angled plate B" which is forced down on the negative by springs acting on a lever D" pivoted to the plate. The plate B" can be raised by the lever D" for the purpose of inserting or removing the negative and paper. The paper and negative are clamped at the other end by a sliding bolt H". When it is desired to examine the print the bolt H" is slid back and the frame or pad turned on the hinge K<11>. In the Provisional Specification a vignetting-frame is described which is hinged to one end of the pad and can be brought over the negative when required.
Patent GB-189729275-A (GB)
Title: Improvements in Fence Posts.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-12-10
Granted: 1898-01-22
Abstract: 29,275. Thompson, W. P., [Bracey, B. G.]. Dec. 10. Fencing.-An angle-iron standard 4 is supported in a terra-cotta base 1. Two forms of section of the latter are shown to a larger scale in Figs. 2 and 6. The angle iron is placed in a suitable position in the central square hole 3, and the spaces are filled in with cement. Holes 6 are made in the sides and ribs of the base to form a tie for the cement.
Patent GB-189729332-A (GB)
Title: Improvements in or connected with Filtering the Feed Water of Steam Generators.
Inventor: DOWNIE THOMAS
Filed: 1897-12-11
Granted: 1898-12-10
Abstract: 29,332. Downie, T. Dec. 11. Filters for steanz generators.-A filter for feedwater, especially for the water from the hot-well of a condensing engine, consists of a vessel f containing filtering-material. The vessel f is enclosed in a casing a and held in place by the cover h. Its upper part is perforated for the admission of the water, and its base is perforated for its discharge. The filter is shown mounted on a heater with a steam coil l terminating in a perforated close end l<1>, but the heater forms no part of the invention. The apparatus is preferably arranged so that the water flows through it from the hot-well by gravity on its way to the feed-pump. The filtering- material may be cleaned or renewed without interrupting the working of the apparatus.
Patent GB-189800289-A (GB)
Title: Improvements in Valves for Pneumatic Tyres, principally for Common Road Vehicles.
Inventor: SANGSTER CHARLES THOMAS BROCK
Filed: 1898-01-05
Granted: 1898-11-26
Abstract: 289. Sangster, C. T. B. Jan. 5. Tyres, pneumatic.-An inflating-valve is shown in section in Fig. 1, and with the parts dissociated in Fig. 4. The tubular valve stem a is connected with an inner conical end a<5> by a narrow part a<2> which has a series of grooves a. The valve stalk d has a conical head d<2> over which is sprung a rubber cap e, and the stalk is prevented from rotating by a wing d' which takes in one of the grooves a<1>. The screwed outer end of the stalk receives a washer nut f, against which bears one end of a spiral spring g encircling the valve-stalk and bearing, at its other end, against the narrow part a<2>. The dust cap i has a middle plug i<1> which screws on to the head of the valve-stalk. The stem is secured by nuts b, c, and the washer h prevents rotation of the stem. In a modification, the end a<5> and cap e may have flat extensions and the dust cap may screw on to the valve stem.
Patent GB-189801676-A (GB)
Title: An Improved Ratchet Pulley.
Inventor: HOLDOM ALFRED EDWARD
Filed: 1898-01-21
Granted: 1898-03-05
Abstract: 1676. Holdom, A. E. Jan. 21. Window blinds.- The runner C has two side springs g, h which engage with side ratchets i.
Patent GB-189804045-A (GB)
Title: Manufacture and Production of Intermediate Products, and of Colouring Matters therefrom.
Filed: 1898-02-17
Granted: 1899-01-07
Abstract: 4045. Green, A. G., Levy, R., and Clayton Aniline Co. Feb. 17. p-Substituted benzaldehyde-o-sulphonic acids are produced from p-diamidostilbene o-disulphonic acid by first substituting for the amido groups, by means of Sandmeyer's reaction, chlorine, cyanogen, ethoxy, methoxy, carboxylic, sulphinic or sulphonic groups, and then oxidizing these stilbene derivatives. Thus, on saturating the diazotized p-diamidostilbene disulphonic acid with sulphurous acid and adding copper dust, stilbenep-disulphinico-disulphonic acid is produced, the solution of which, after being freed from sulphurous acid by means of a stream of air, and from copper by adding sodium sulphide, is oxidized by slowly adding cold permanganate solution to form benzaldehyde o-p-disulphonic acid, the sulphinic group being oxidized to the sulphonic group simultaneously with the destruction of the ethylene linkage. Dyes, artificial, of the triphenylmethane group, which are fast to alkalies, are produced by condensing one of the foregoing p-substituted derivatives of benzaldehyde-o-sulphonic acid with secondary or tertiary aromatic amines, or sulphonic acids thereof, and then oxidizing the resulting leuco compound by means of lead peroxide or the like. For example, when the benzaldehyde-o-pdisulphonic acid described above is condensed with dimethylaniline, and the leuco product is oxidized, a dye is obtained which yields bright greenish-blue shades on silk and wool, fast to alkalies.
Patent GB-189814700-A (GB)
Title: Improved Brake Blocks.
Inventor: THOMSON ROBERT
Filed: 1898-07-04
Granted: 1899-04-29
Abstract: 14,700. Thomson, R. July 4. Brakes.-Brake blocks for vehicles having rubber and like tyres are made of tough lead glass in order to diminish wear on the tyre.
Patent GB-189817651-A (GB)
Title: Improvements in Elastic Tyres for Wheels.
Inventor: BOGUSLAVSKY ALEXANDER
Filed: 1898-08-16
Granted: 1899-08-16
Abstract: 17,651. Boguslavsky, A., and Gunn, L. Aug. 16. Tyres, elastic other tha n pneumatic.-The elastic tyre, shown in section, comprises two U-shaped rubber rings A, A', placed face to face and secured t ogether by steel or similar rings B, B<1>, which are connected to the flanges a, a<1> by any means such as bolts d. The space between the rubber rings is filled with wood or other tough pieces S, which are preferably cemented to inner rubber rings c'. Leather or similar strips c may be interposed between the pieces S, and parts S<1> may be cut away to allow of radial motion. The parts b<2> of the rings B, B<1> are connected by transverse bolts b<3> which pass through slots s in the pieces S. In a modification, the flanges a, a' are in contact. Spokes, securing. The bolts d may screw on to the ends of the spokes e.
Patent GB-189818009-A (GB)
Title: Improved Method of Corrugating, Fluting, or Imparting an Ornamental Shape to Sheet Metal and other Objects.
Inventor: BOULT ALFRED JULIUS
Filed: 1898-08-22
Granted: 1899-02-11
Abstract: 18,009. Boult, A. J., [Pollak, L.]. Aug. 22. Bending; corrugating; metal, sheet, beading.-Sharply-outlined projections, corrugations, beadings, mouldings, flutings, and ornamentations are formed on sheet metal, cylindrical hollow articles such as tins, &c., by subjecting the metal while being acted upon by the shaping &c. rolls to a pressure acting on its edges in the direction of the axes of the rolls. Fig. 1 shows an elevation of a machine, for shaping tins C, provided with two rolls B, B<1> driven by pulleys 1, 2 and gearing 4, 5, the spindle b<1> of the roll B' being carried in an oscillating bearing 3. The edge of the tin C is received in a stepped ring E supported eccentrically to the shaft b<1> on rollers 13 carried in slides 11 adjustably fixed on a plate 9 vertically adjustable on a cross-bar 7 extending between the shafts b, b<1> and mounted on rods 6 which can be clamped in lugs a. Pressure is applied to the bottom of the tin by the disc F on a shaft f movable by treadle &c. mechanism. The shaft f is mounted in a vertically-adjustable bracket D', and is driven by gearing 24, 25 from the prolonged shaft b of the top roll.
Patent GB-189822443-A (GB)
Title: Improved Impermeable Leather.
Inventor: STRACHOCINSKI JOSEPH
Filed: 1898-10-25
Granted: 1898-11-26
Abstract: 22,443. Strachocinski, J., and Stoldt, C. Oct. 25. Leather prepared from stomachs.-Leather impervious to water is prepared by tanning animal stomachs. The rough inner side is treated with alum, and the irregularities removed by the usual processes employed in leather manufacture The stomach is afterwards tanned, dried by exposure to air, and finished in the usual way.
Patent GB-189823694-A (GB)
Title: Improvements in Typewriting Machines.
Inventor: BRACKELSBERG ERNST WILHELM
Filed: 1898-11-10
Granted: 1899-01-07
Abstract: 23,694. Brackelsberg, E. W. Nov. 10. Type-writers.-Relates to machines having a number of typesegments placed side by side. Each segment a<2>, a<3> is fixed on a separate shaft b<2>, b<3>, &c., and is connected by a link c<2>, c<3>, &c. to a lever e<2>, e<3>, &c. The levers e<2> &c. are placed side by side, and each is operated by one or more rows of keys h which, when depressed, engage the plates f of the levers e<2> &c. To position the segments properly when printing, a bar j is caused to engage notches in the rear sides of the segments, as shown.
Patent GB-189825286-A (GB)
Title: Improvements in the Manufacture of Compositions having as a Basis Oxidized Oil or Oxidized Oil and Fibrous Material.
Inventor: GRIST CHARLES JAMES
Filed: 1898-11-30
Granted: 1899-11-25
Abstract: 25,286. Grist, C. J. Nov. 30. Joint making packing.-Relates to the preparation of compositions such as are described in Specifications Nos. 21,742 and 22,574, A.D. 1895. Linseed oil is partially oxidized by heating, after litharge or the like has been added. Fibres of jute, hemp, cotton, &c., or animal fibres, in a clean and dry condition, are dipped in the oil and then placed in a hydro-extractor. Alternatively the loose fibre may be placed in the extractor and oil poured over it. When the surplus oil has been removed, by the action of the extractor, the fibres are spread out on wire gauze or the like, and the oxidization of the adhering particles of oil is completed by currents of heated air. The process of dipping, removing surplus oil, and oxidizing is repeated from six to ten times, or even more, the speed of the extractor being greatly increased during the later repetitions of the process, as otherwise the oxidization of the oil is not sufficiently complete. The material is next masticated or ground between rolls, and colouring or hardening materials such as French chalk, ochre, asbestos, &c. are worked in. A quantity of sulphur is next worked into the mixture, and in some cases resin, whitening; plumbago, india-rubber, gutta-percha, waste vulcanized rubber, slate dust, &c. are incorporated with it, either for cheapening the product or for improving it for the special purpose to which it is to be put. When used for packing, the material is rolled out into sheets.
Patent GB-189827361-A (GB)
Title: Improvements relating to the Manufacture of "Crepon" or Crinkled Cotton Fabrics.
Filed: 1898-12-28
Granted: 1899-10-14
Abstract: 27,361. Kay, W. E., and Thornliebank Co. Dec. 28. Crimped cotton fabrics. - Crepon or crinkled cotton fabrics are produced by weaving yarns which have been previously silked or lustred by mercerization under tension, and protected by suitable resists against the action of caustic alkali, in combination with yarns which have not been so protected, and afterwards treating the cloth with a solution of caustic alkali for the purpose of shrinking or mercerizing the non-protected parts.
Patent GB-189902617-A (GB)
Title: Improvements in Water-gauge Cocks.
Inventor: WARREN JOHN HARLOW
Filed: 1899-02-06
Granted: 1899-03-18
Abstract: 2617. Warren, J. H. Feb. 6. Gauge cocks.-The closing-spring D of the cock is situated outside the casing, so as not to be exposed to the heating action of steam and water. When the valve c is opened, by depressing the end of the bent lever E, the valve face b engages a seat 7 and prevents leakage. Annular recesses b<1> are formed in the extension B, and in these the small amount of steam which does leak is condensed and forms a water packing. The outlet a is situated between the two valve seats in the diaphragms 3 and 4, as shown.
Patent GB-189902883-A (GB)
Title: Improvements in the Treatment and Roasting of Grain for Use in Coloring and Increasing the Palate Fullness of Beer.
Filed: 1899-02-09
Granted: 1900-01-06
Abstract: 2883. Johnson's Saccharum Co. and O'Neill, E. H. Feb. 9. Processes of treating grain; roasting grain; flake products, obtaining.-Relates to a process for treating grain for use in brewing ale and stout. The grain is mixed with sucrose, glucose, dextrose, lµvulose, maltose, glycyrrhizin, dextrin, or caramel, and roasted, preferably with the addition of a small quantity of carbonate of ammonia to lower the caramelizing temperature. The roasted grain is steamed and flaked between smooth rolls. The product is used for colouring and increasing the palate fullness of the beer.
Patent GB-189906314-A (GB)
Title: Improvements in Corsets.
Inventor: TINSLEY JANE
Filed: 1899-03-23
Granted: 1900-01-20
Abstract: 6314. Tinsley, J. March 23. Corsets are constructed so that the part covering the abdomen can be regulated in size as required. The busks A are prolonged at the lower ends and made more pointed than usual at this part, and the lower part of the corset is cut so as to form two flaps B, C, which are laced together to any required degree of tightness.
Patent GB-189908984-A (GB)
Title: An Improved Method and Means for Refining and Strengthening Iron and Steel for Casting or Founding purposes.
Inventor: EVANS JAMES
Filed: 1899-04-29
Granted: 1899-06-24
Abstract: 8984. Evans, J., and Smith, R. A April 29. Casting, treating iron or steel for. A mixture of oxide of lead, bicarbonate of soda, and nitrate of potash is introduced into molten iron or steel for casting or founding purposes. The mixture may be used either alone, or together with bauxite, sand, or other suitable medium. The metal may be treated during any of its processes of manufacture.
Patent GB-189910107-A (GB)
Title: Improvements relating to Mixing and Grinding Mills for the Manufacture of White Lead, Paints, and other Substances.
Inventor: TORRANCE THOMAS
Filed: 1899-05-13
Granted: 1899-07-01
Abstract: 10,107. Torrance, T., and Torrance, J. R. May 13. Edge-runners and pans for mixing and grinding white lead, paints, &c. Relates to improvements in the mill described in Specification No. 6263. A.D. 1890. The head a of the rotating shaft of the mill supports an annular vessel d, into which oil is fed by a pipe h and from which it is delivered in a circular path in the pan of the mill by another pipe i. The white lead &c. is fed by a pipe e into the centre of the annular vessel, and is delivered into the pan by a pipe f<1>. A door k in the pan is opened, after the material has been sufficiently treated, to allow of its being discharged into a receiver m provided with a conveyer n and with an adjustable outlet p through which it passes to the granite-roller mill r.
Patent GB-189911572-A (GB)
Title: Improvements in and relating to Rotary Engines.
Inventor: TULLOCH DAVID
Filed: 1899-06-05
Granted: 1900-06-05
Abstract: 11,572. Tulloch, D. June 5. Annular-chamber type.-A wheel A is centrally mounted, on a shaft A', inside the chamber B, and carries a vane A<2>, which rotates in the annular chamber B<1>. Sliding abutments G, worked by external eccentrics or by the wheel A, divide the annular chamber into two parts, into which steam is admitted and exhausted through steam valves e and corresponding exhaust valves. The valves are controlled by cams H acting on arms H<1> on the valve spindles. The engine can be worked expansively, and is made reversible by duplicating the valves and steam passages.
Patent GB-189911724-A (GB)
Title: Improvements in and relating to Boiler Furnaces.
Inventor: FROEHLICH BERNHARD
Filed: 1899-06-06
Granted: 1899-07-22
Abstract: 11,724. Fr÷hlich, B. June 6. Smoke-consuming.-In a boiler furnace, a cellular or equivalent air-heating device a is arranged within the substance of the firebridge, and provided with an inlet opening and door c so constructed that air can enter only at or near the top of the ashpit.
Patent GB-189912331-A (GB)
Title: Improvements in Bicycles.
Inventor: MORANDI GIUSEPPE
Filed: 1899-06-13
Granted: 1900-04-07
Abstract: 12,331. Morandi, G. June 13. Bicycles are formed with the front wheel smaller than the rear wheel and a shorter frame. Collapsable and folding bicycles.-The invention is shown as applied to a lady's bicycle. The front and rear frames B, B are connected by a hinge piece with a vertical pivot A, Fig. 5, and when in the normal position are locked by teeth D carried on a vertically-sliding spring piece C engaging recesses E in the movable jaw of the hinge. When the piece C is depressed, the bicycles can be folded as shown in Fig. 2, and the parts may be retained in position by a spring catch. Instead of connecting the front and rear frames by a hinge, they may be made with interfitting parts as shown in Fig. 9, which can be locked together by a rotating flanged collar which turns on one part and engages wedgeshaped projections on the other part. Handle-bars, folding. The handle-bars are arranged to fold as shown in Fig. 15, and are locked in position by a spring piece similar to that used for the frame. The folded bars are locked by a spring catch n, o. Saddle supports; brakes.-The saddle is carried by a bracket b, Fig. 17, mounted on a tube y which fits on the tube x and is locked by a spring sliding piece y' which carries teeth engaging slots in the tube y. When the piece y<1> is pushed forward, the saddle can be folded as shown in Fig. 2. In order to apply a brake to the back wheel when the bicycle is folded, the saddle support is lowered, causing a plate e to strike a projection f and thus depress a rod carrying a brake shoe. The brake is taken out of action by a spring. A spring m and rod l serve to determine the height of the saddle.
Patent GB-189915171-A (GB)
Title: Improvements in Automatic Couplers for Railway and like Vehicles.
Inventor: OLIVER MARWOOD JOHN
Filed: 1899-07-24
Granted: 1900-05-26
Abstract: 15,171. Oliver, M. J. July 24. Couplings, automatic. - Fig. 2 shows a side elevation, and Fig. 3 a plan. The link b, pivoted to the draw-hook a, has lateral arms c and a pivoted shackle f, which is free to fall backward of, but not forward of, the centre line of the link. When the buffer plates d strike the arms c, the shackle is swung over into engagement with the adjacent hook. The vehicles are uncoupled by depressing one of the arms c.
Patent GB-189916514-A (GB)
Title: Improvements in the Production of Copper Alloys.
Inventor: PALIS GUSTAV
Filed: 1899-08-14
Granted: 1900-08-11
Abstract: 16,514. Palis, G., and R³gge, H. Aug. 14. Alloys.-Copper, iron, and manganese are melted together with or without the addition of nickel or cobalt, and to the mixture a suitable de-oxidizing material is added. This material consist of a combination or preparation of phosphorus, ammonium chloride, soda, magnesium, and boracic acid. As soon as this addition is absorbed by the fluid metal bath, zinc is introduced and the melting process continued. The gases and oxides still remaining in the molten alloy are eliminated by placing the alloy in a rotating apparatus, which has also a reciprocating motion.