baber/WOPTO huggingface dataset:
Patent DE-69406284-D1 (DE)
Inventor: HEYKANTS Jozef
IPC: A61K31/428
Filed: 1994-06-06
Granted: 1997-11-20
Abstract: PCT No. PCT/EP94/01849 Sec. 371 Date Nov. 16, 1995 Sec. 102(e) Date Nov. 16, 1995 PCT Filed Jun. 6, 1994 PCT Pub. No. WO94/29305 PCT Pub. Date Dec. 22, 19942-[[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]methylamino]-benzothiazololes    <IMAGE>  (I)  variable always being hydrogen, and the pharmaceutically acceptable acid addition salts thereof. Novel compounds, pharmaceutical compositions, as well as their use as a class III antiarrhythmicum is disclosed.
Patent DE-69407807-D1 (DE)
Inventor: TSUCHIYA SHINJI TOKYO TANABE C
IPC: C07D403/06
Filed: 1994-09-30
Granted: 1998-02-12
Abstract: Indoline compounds represented by the general formula: <CHEM>  wherein R<1> represents the group <CHEM> R<2> represents a phenyl group which may be substituted or an aromatic heterocyclic group, and R<3> represents hydrogen, a halogen, or a lower alkyl group, hydroxyl group, lower alkoxy group, carbamoyl group or lower alkoxycarbonyl group, and physiologically acceptable salts thereof, and their solvates, as well as 5-HT3 receptor antagonists containing them as effective components. The indoline compounds of the invention have stronger antagonism against intestinal 5-HT3 receptors than known 5-HT3 receptor antagonists and also have excellent sustained action, making then useful as prophylactic or therapeutic agents against vomiting or irritancy induced by chemotherapy or radiation, irritable bowel syndrome, diarrhea, and the like.
Patent DE-69419780-D1 (DE)
Inventor: RYGAARD JORGEN
IPC: A61B18/24
Filed: 1994-04-12
Granted: 1999-09-02
Abstract: PCT No. PCT/DK94/00148 Sec. 371 Date Aug. 22, 1996 Sec. 102(e) Date Aug. 22, 1996 PCT Filed Apr. 12, 1994 PCT Pub. No. WO95/17127 PCT Pub. Date Jun. 29, 1995A method of locating a constriction in a coronary artery and performing an arteriotomy distally thereof which comprises locating the site of a constriction in a coronary artery by scanning the artery with a non-invasive sensing instrument capable of detecting the constriction. The sensing instrument has associated therewith a cutting instrument comprised of a cutter and member for moving the cutter into a position for making an incision. After the constriction is located, the cutting member is moved into a cutting position distal of the constriction and an incision is made through the wall of the artery into the lumen thereof.
Patent DE-69420536-D1 (DE)
Inventor: HOLLOWAY THOMAS
IPC: A45D40/06
Filed: 1994-07-05
Granted: 1999-10-14
Abstract: Containers for cosmetics such as lipstick, with refill cartridges that must be used with the whole container, avoid problems such as separation during normal use. The refill cartridge comprises a cosmetic holder including: a tubular innerbody, a tubular cam sleeve surrounding substantially the entire length of the innerbody; and an elevator cup within the innerbody. The extension of the cam sleeve over the innerbody, inhibits the relative movement of these two elements, unless a base member configured to fit between them and impart relative torque is in place. A retaining means is provided to hold the refill and the base member together.
Patent DE-69425152-D1 (DE)
Inventor: ANDERSSON HJALMAR
IPC: A61K31/4422
Filed: 1994-11-03
Granted: 2000-08-10
Abstract: PCT No. PCT/SE94/01031 Sec. 371 Date Dec. 14, 1994 Sec. 102(e) Date Dec. 14, 1994 PCT Filed Nov. 3, 1994 PCT Pub. No. WO95/12578 PCT Pub. Date May 11, 1995Compounds of the general formula    <IMAGE>  I  wherein R1 and R2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano, trifluoromethyl, and R3 and R4 are independently selected from straight or branched lower (1-5 carbon atoms) alkyl groups, and including all optical isomers, provided that when R3 is methyl and R4 is tert.-butyl, then R1/R2 are not hydrogen/hydrogen, hydrogen/2'-trifluormethyl, 2'-chloro/3'-chloro, and when R3 is methyl and R1/R2 is hydrogen/3'-nitro, then R4 are not methyl, ethyl, propyl, iso-propyl, tert.-butyl, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in lowering the blood pressure.
Patent DE-69431202-D1 (DE)
Inventor: BORNHORST F
IPC: B44B3/04
Filed: 1994-05-04
Granted: 2002-09-26
Abstract: A method and apparatus for automated loading and unloading of a cylinder in an engraver. The method and apparatus permit the engraver to accommodate cylinders of differing geometries, including a range of lengths, diameters and mounting configurations. The engraver includes a headstock and a tailstock which cooperate to rotatably support a cylinder at an engraving station in the engraver. The engraver includes a cylinder handling system having at least one cylinder supporting the cylinder between the headstock and the tailstock during the loading and unloading of the cylinder. The cylinder handling system includes a driver for driving the cylinder support towards and away from the engraving station until the headstock and the tailstock engage and rotatably support the cylinder. Once the cylinder is rotatably supported between the headstock and the tailstock, then the cylinder support is retracted. The cylinder support includes a telescoping support member having a support nest for engaging and supporting the cylinder at the engraving station.
Patent DE-69503769-D1 (DE)
Inventor: COHAN VICTORIA
IPC: A61P37/04
Filed: 1995-02-03
Granted: 1998-09-03
Abstract: This invention relates to isoxazoline compounds which are inhibitors of tumor necrosis factor (TNF). The isoxazoline compounds are useful for inhibiting TNF in a mammal in need thereof and in the treatment or alleviation of inflammatory conditions or disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tuberculosis, graft versus host disease and cachexia associated with AIDS or cancer. This invention also relates to pharmaceutical compositions useful therefor comprising such compounds.
Patent DE-69518832-D1 (DE)
Inventor: SVENSSON STIG
IPC: A61B6/00
Filed: 1995-04-07
Granted: 2000-10-19
Abstract: PCT No. PCT/FI95/00193 Sec. 371 Date Dec. 4, 1996 Sec. 102(e) Date Dec. 4, 1996 PCT Filed Apr. 7, 1995 PCT Pub. No. WO95/27922 PCT Pub. Date Oct. 19, 1995An apparatus for making X-ray images includes an X-ray source which is controlled by an X-ray source control. A luminescent screen provides a visible image based upon X-rays transmitted by the X-ray source. A CCD camera receives and stores the visible image. Imaging optics including a mirror reflect the visible image to the camera without splitting the visible image into parts. A photosensor is in optical communication with the luminescent screen and is separate from the CCD camera. The photosensor is positioned such that an illumination power of the luminescent screen falls on the photosensor practically from within an area of an entire portion of the visible image. A computer and control connectable to the X-ray source control for adjusting exposure of the apparatus is connected to the photosensor.
Patent DE-69525467-D1 (DE)
Inventor: STRINGER DR
IPC: C12N5/10
Filed: 1995-11-03
Granted: 2002-03-21
Abstract: The invention relates to a method of producing nerve cell-lines comprising a homogenous population of nerve cells having preselected biochemical/functional characteristics. In addition, the invention also concerns the provision of a homogeneous population of cells which can be selectively made to undergo apoptosis. Finally, the invention also concerns nerve cell-lines provided by the method of the invention.
Patent DE-69527346-D1 (DE)
Inventor: NICOLAOU C
IPC: C07D409/14
Filed: 1995-01-11
Granted: 2002-08-14
Abstract: Onium salts of taxo-diterpenoid-Cn,2-O-aza-arenes form water soluble self-assembling nanostructures above a critical aggregation concentration. The onium salt of aza-arene includes a delocalized charge which renders derivatized taxo-diterpenoids amphoteric, enhances their solubility in water, and promotes self-assembly of water soluble nanostructures, e.g., helical fibular structures and spherical micellular structures. These same onium salts of taxo-diterpenoid-Cn,2-O-aza-arenes are employed as water soluble prodrugs. For example, taxol-2'-methylpyridinium tosylate (MPT) is characterized by an elevated aqueous solubility, rapid activation by serum protein, good stability in most other aqueous solutions, formation of a protein:taxol intermediate and good retention within the circulatory system. The toxicity of the activated form is comparable or greater than underivatized taxol. Furthermore, taxol-2'-MPT can be synthesized by a simple one step reaction between taxol and 2-fluoro-1-MPT. The invention is applicable to taxol and taxol memetics having hydroxyls that are reactive with onium salts of 2-halogenated-aza-arenes. For example, taxol, C-2 substituted taxol and Taxotere each have reactive hydroxyls at the 2' and 7 positions. The invention is also applicable to a wide array of 2-halogenated-aza-arenes.
Patent DE-69530589-D1 (DE)
Inventor: MAHONEY J
IPC: A61K9/70
Filed: 1995-07-14
Granted: 2003-06-05
Abstract: PCT No. PCT/EP95/02772 Sec. 371 Date Jul. 7, 1997 Sec. 102(e) Date Jul. 7, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02285 PCT Pub. Date Feb. 1, 1996A non-immunogenic, bioerodible implantation composition which comprises alginate fibres.
Patent DE-69531682-D1 (DE)
Inventor: BYSKOV GRETE
IPC: A61K31/575
Filed: 1995-06-23
Granted: 2003-10-09
Abstract: The present invention relates to certain sterol derivatives for use as medicaments.
Patent DE-69532766-D1 (DE)
Inventor: HOBART M
IPC: A61K47/44
Filed: 1995-11-28
Granted: 2004-04-29
Abstract: The present invention relates to plasmids suitable for IL-2 expression, particularly, human IL-2 expression, and related methods. The plasmid consists essentially of an expression facilitating sequence derived from the immediate-early promoter region of CMV, an expression facilitating sequence derived from the transcriptional termination/polyadenylation signal sequence of the BGH gene, a sequence coding for the eukaryotic expression of an IL-2, possessing a bioactivity of the complete IL-2, operably linked to both of said expression facilitating augments eukaryotic expression compared to a wild-type IL-2 leader peptide. Optionally, the plasmid also includes a non-mammalian origin of replication and a sequence operably encoding a selectable marker.
Patent DE-69535890-D1 (DE)
Inventor: CRAIN STANLEY M
IPC: G01N33/94
Filed: 1995-07-18
Granted: 2009-01-02
Abstract: This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side effects caused by the chronic administration of said bimodally-acting opioid agonists comprising the coadministration of a bimodally-acting opioid agonist which activates both inhibitory and excitatory opioid receptor-mediated functions of neurons in the nociceptive (pain) pathways of the nervous system and an opioid receptor antagonist which selectively inactivates excitatory opioid receptor-mediated side effects. This invention also relates to a method of using excitatory opioid receptor antagonists alone to block the undesirable excitatory side effects of endogenous bimodally-acting opioid agonists which may be markedly elevated during chronic pain. This invention further relates to a method of long-term treatment of previously detoxified opiate, cocaine and alcohol addicts utilizing said excitatory opioid receptor antagonists, either alone or in combination with low-dose methadone, to prevent protracted physical dependence, and to compositions comprising an excitatory opioid receptor antagonist of the invention and a bimodally-acting opioid agonist.
Patent DE-69607523-D1 (DE)
Inventor: OUSLEY BENSON III
IPC: B63H21/32
Filed: 1996-01-04
Granted: 2000-05-11
Abstract: An improved marine engine exhaust system for discharging engine exhaust above the water line when at idle or low speeds, and below the surface of the water at high speed in a submerged turbulent region generated by a hydrodynamic fitting fixed to a the undersurface of the vessel hull, wherein the gas is maintained for a period of time, until the low pressure area following the vessel has passed.
Patent DE-69623406-D1 (DE)
Inventor: ROBERTS JEFFREY B
IPC: H02H3/40
Filed: 1996-10-11
Granted: 2002-10-10
Abstract: A directional element (40) which produces a quantity  zeta o related to the zero sequence source impedance of a power system relative to the location of the directional element (40), from values of zero sequence current (IR) and an adjusted value of zero sequence voltage (3Vo). The impedance quantity ( zeta o) is then compared against first and second threshold quantities (ZOF and ZOR) to identify the direction of a fault. Further, the zero sequence voltage-polarized directional element can be combined with other individual directional elements, induding a zero sequence current-polarized directional element and a negative sequence voltage-polarized directional element to form a universal directional element for unbalanced faults, in which the individual directional elements operate in a particular sequence, with the other directional elements being blocked from operating if a prior directional element in the sequence provides a direction indication. <IMAGE>
Patent DE-69635706-D1 (DE)
Inventor: BAICHWAL R
IPC: A61K9/00
Filed: 1996-04-04
Granted: 2006-03-30
Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.
Patent DE-69702981-D1 (DE)
Inventor: SHAH JAYESH
IPC: B32B27/08
Filed: 1997-06-18
Granted: 2000-10-05
Abstract: Aminoplast and phenoplast particles are obtained by providing an aqueous solution of such a resin having a water tolerance level, adding a particulate core-forming material in solid form, e.g. mineral particles or cured resin particles, as well as a mixture of water and a stabilizing agent, the amount of water being sufficient to exceed the water tolerance level of the aminoplast or phenoplast, and thus forming an emulsion or suspension of the resin coated particles in water, and advancing cure of the resin to form partially or fully cured resin coatings having a thickness preferably about 5-75  mu m encapsulating the particulate core-forming material.
Patent DE-69737147-D1 (DE)
Inventor: FUKUI TOMIO
IPC: E02D17/20
Filed: 1997-10-20
Granted: 2007-02-08
Abstract: Erosion or collapse of a stream or a river is prevented by mooring timber, stones, or the like with a longitudinal cable (steel cable) (1). Barrier-like members (3) such as timber and stones moored by using the longitudinal cable (1) are arranged substantially stepwise or parallel to each other on the ground near the eroded or collapsed place to prevent mountain landslides. <IMAGE>
Patent DE-69807250-D1 (DE)
Inventor: NIELSEN MARINUS
IPC: C02F3/12
Filed: 1998-09-16
Granted: 2002-09-19
Abstract: A process for biological purification of waste water by the activated sludge method wherein the waste water is continuously passed through one or more treatment zones and a clarification zone, wherein the waste water treated in the last treatment zone at the outlet from the zone under suitable control of aeration and stirring is continuously divided into a predominantly aqueous fraction and a sludge-containing fraction, and wherein a portion of the sludge fraction is recirculated and mixed with non-treated waste water, of which the former is subjected to clarification, and the latter is recirculated to the same or a preceding treatment zone.
Patent DE-69815205-D1 (DE)
Inventor: GENIN THIERRY
IPC: E06B9/80
Filed: 1998-03-31
Granted: 2003-07-10
Abstract: The motorised roller blind or shutter is driven by an electric motor, and is fitted with an automatic detector to switch off the supply to the motor when the blind or shutter reaches the end of its travel. The detector senses the change in the weight of the blind when it makes contact with an object. The roller is supported at its two ends by an arm connected to a fixed support. A spring compensates the weight of the roller mechanism. The orientation of the arm varies with the weight of the roller mechanism, with the raising of the arm operating the contacts that initiate switching of the supply.
Patent DE-69826488-D1 (DE)
Inventor: THIERRY ALAIN
IPC: A61K48/00
Filed: 1998-07-30
Granted: 2004-10-28
Abstract: This invention concerns stable particulate complexes with a neutral or negative global charge of lamellar structure made consisting of at least one globally anionic biologically active substance and mixture of a cationic constituent and an anionic constituent. The invention also concerns unilamellar vesicles for preparation of these complexes as well as their preparation and utilisation.
Patent DE-69828631-D1 (DE)
Inventor: ARQUETTE JAMES
IPC: A61K8/891
Filed: 1998-10-15
Granted: 2005-02-17
Abstract: An emollient composition is derived from jojoba oil comprises: at least 10% by weight fatty alcohols comprising:R1CH2-OHat least 10% by weight of alkyl esters comprising:R1-COO-R4andwax esters selected from the group consisting of:R1-COO-CH2-R2andR2-COO-CH2-R1,wherein R4 comprises an alkyl or other aliphatic group, R1 comprises CH3-(CH2)7-CH=CH-CH2-(CH2)x-, and R2 comprises CH3-(CH2)y wherein x is 6, 8, 10 and 12, and y is 16, 18, 20 and 22. These emollient compositions may be used as emollient carriers for various materials to be externally applied to the skin.
Patent DE-69831971-D1 (DE)
Inventor: WEINER L
IPC: A61K38/17
Filed: 1998-12-03
Granted: 2006-03-02
Abstract: Methods are provided for treating or preventing Alzheimer's disease comprising mucosally administering  beta -amyloid peptide or a fragment or analog thereof in an oral or other mucosal dosage form. Also disclosed herein are pharmaceutical formulation or dosage forms for use in these methods.
Patent DE-69832530-D1 (DE)
Inventor: ERIKSSON SOEREN
IPC: G02F1/1343
Filed: 1998-12-02
Granted: 2005-12-29
Abstract: The present invention relates to a display (10; 11; 12) which comprises an electrode layer (21), a substrate (30), which on the surface facing the electrode layer (21) is covered with a set of electrode elements (31), and a layer of electro-optic material (40) which is arranged between the electrode layer (21) and the substrate (30). The substrate (30) is arranged behind the layer (40) of electro-optic material in relation to the viewing direction and supports, on the one hand, electronic components (33) for controlling the electrode elements and, on the other, conductive patterns (34) for connecting the electronic components (33) to the ele ctrode elements (31). The electrode elements (31) form picture elements in the display (10; 11; 12) in cooperation with the electrode layer (21) and the layer of electro-optic material (40). According to the invention, the electrode elements (31) are connected to the conductive pattern (34) by means of connections emanating backwards from the electrode elements (31) and mutually positioned in such a manner that they form a substantially continuous surface of electrode elements.
Patent DE-69837684-D1 (DE)
Inventor: HOLTON ROBERT A
IPC: C07D305/14
Filed: 1998-08-17
Granted: 2007-06-06
Abstract: A process is described for converting the C(7) hydroxy group of a 10-acyloxy-7-hydroxytaxane to an acetal or ketal, the process comprising treating the 10-acyloxy-7-hydroxytaxane with a ketalizing agent in the presence of an acid catalyst to form a C(7) ketalized taxane of the formula or wherein either X<sup>31</sup> or X<sup>32</sup> represents the 10-acyloxy-7-hydroxytaxane moiety and the other of X<sup>31</sup> and X<sup>32</sup> as well as X<sup>33</sup> and X<sup>34</sup> are independently hydrocarbyl, substituted hydrocarbyl or heteroaryl moieties. Taxanes having a ketalized C(7) hydroxy group are also described.
Patent DE-69904055-D1 (DE)
Inventor: SYMONS WINDSOR
IPC: B29C41/00
Filed: 1999-07-28
Granted: 2003-01-02
Abstract: A process for manufacturing a moulding such as an architectural moulding or a picture or photo frame, includes the steps of providing a substrate such as a polymeric extrusion; providing a paste comprising a thermoplastic elastomer, a thermoplastic polymer, an inorganic particulate filler and an amount of a solvent to dissolve or wet the various components to form the paste; applying to the substrate a layer of the paste; shaping the paste to a desired shape; and allowing the paste to dry so that it adheres to the substrate to form the moulding.
Patent DE-69907023-D1 (DE)
Inventor: PALTIN ELI
IPC: A01M15/00
Filed: 1999-11-16
Granted: 2003-05-22
Abstract: A mobile soil-disinfecting device (10) comprising a cultivating unit (20), a soil treating chamber (23), a bellows (28), a heat exchanger (56), and a heat-generating unit (26). The cultivating unit (20) comprises one or more cultivating members adapted for breaking the soil and throwing it upwardly into the soil treating chamber (23), and the heat exchanger (56) being in thermal communication with the heat generating unit (26), the bellows (28) adapted for drawing ambient air, passing the air through the heat exchanger (56) and throwing hot air into the soil treating chamber (23).
Patent DE-69908322-D1 (DE)
Inventor: CAMERON STANLEY
IPC: B01J39/04
Filed: 1999-03-16
Granted: 2003-07-03
Abstract: A method of removing ammonium ions or amines from contaminated water includes treating the water with sodium tetraphenylborate under acidic conditions. Advantageously, the tetraphenylborate is immobilized on polymer beads and the water is contacted with the beads or passed through a bed of the beads.
Patent DE-69918711-D1 (DE)
Inventor: FELGNER L
IPC: C07C311/64
Filed: 1999-11-24
Granted: 2004-08-19
Abstract: Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.
Patent DE-69919003-D1 (DE)
Inventor: ANAEBONAM O
IPC: A61K9/50
Filed: 1999-09-03
Granted: 2004-09-02
Abstract: An extended release acetaminophen composition comprises particles containing acetaminophen coated on sugar/starch seeds. The particles are present as a blend of both an immediate release and a controlled release form. The composition, when contained within a gelatin capsule and assayed in a USP Apparatus I rotating basket at 50 rpm in 900 mL of phosphate buffer at pH 5.8 and a temperature of 37 °C, exhibits about 40 percent acetaminophen dissolution at one-half hour, about 55 percent acetaminophen dissolution at one hour, and substantially complete dissolution of acetaminophen at six hours. A process for treating a human patient with the extended release acetaminophen composition is also disclosed.
Patent DE-69919753-D1 (DE)
Inventor: YANG BYUNG
IPC: C08F10/02
Filed: 1999-10-23
Granted: 2004-09-30
Abstract: The present invention relates to a catalyst for homo-polymerization or co-polymerization of ethylene, or more particularly to a solid complex titanium catalyst for homo-polymerization or co-polymerization of ethylene. The catalyst may be produced by preparing a magnesium solution by contact-rcacting a magnesium halide compound with alcohol. Reacting the solution with an ester compoound and a silicon compound. Then reacting the solution with a mixture of a titanium compound and a silicon compound.