baber/WOPTO huggingface dataset:
Patent TW-I409051-B (TW)
Title: A device and a method of improved estimation of pressure at remote site by brachial oscillometric waveform analysis
Inventor: CHEN CHEN HUAN
IPC: A61B5/021
Filed: 2007-12-10
Granted: 2013-09-21
Abstract: The present invention relates to a device and a method for estimating central systolic blood pressure based on oscillometric signals from brachial artery by the use of a pressure cuff.
Patent TW-I459505-B (TW)
Title: Electrical interconnect structure and method
Inventor: BUCHWALTER STEPHEN LESLIE
IPC: H01L21/768
Filed: 2008-04-03
Granted: 2014-11-01
Abstract: An electrical interconnect forming method. The electrical interconnect includes a first substrate comprising a first electrically conductive pad, a second substrate comprising a second electrically conductive pad, and an interconnect structure electrically and mechanically connecting the first electrically conductive pad to the second electrically conductive pad. The interconnect structure comprises a non-solder metallic core structure, a first solder structure, and a second solder structure. The first solder structure electrically and mechanically connects a first portion of the non-solder metallic core structure to the first electrically conductive pad. The second solder structure electrically and mechanically connects a second portion of the non-solder metallic core structure to the second electrically conductive pad.
Patent TW-I415690-B (TW)
Title: Die coater, die coater adjusting method, and method for production of optical films
Inventor: KOMATSUBARA MAKOTO
IPC: B29C48/31
Filed: 2008-04-23
Granted: 2013-11-21
Abstract: An object of the present invention is to provide a die coater that is capable of applying a coating liquid to a uniform thickness, while employing a relatively simple structure and reducing the frequency of readjustment necessitated due to the change over time. A die coater includes a first block and a second block disposed opposite to each other with a slit formed in a leading end thereof acting as an ejecting port for ejecting a coating liquid, and a shim held between the first block and the second block, in which the width of the slit is adjustable according to the thickness of the shim, and the shim has surfaces in which recessed portions are formed partially in a longitudinal direction of the slit.
Patent TW-I345544-B (TW)
Title: Carton packaging with film internal container and prefabricated carton unit for the production thereof
Inventor: RAUPACH ROLAND
IPC: B31B50/00
Filed: 2008-07-11
Granted: 2011-07-21
Abstract: In carton packaging having an outer folding carton and an inner folding carton which surrounds a film internal container, the inner folding carton is adhesively bonded by means of one of its carton body walls (14) to an adjacent carton body wall (6) of the outer folding carton. The outer folding carton and the inner folding carton surround the film internal container essentially completely. The film internal container consists of a flexible film internal bag provided with a withdrawal closure. The carton body walls (13, 14, 15, 16) of the inner folding carton are connected to one another in a foldable manner at the body edges (17, 18, 19, 20) via carton bridges, each bridging an edge slot. The lid flaps of the inner folding carton are angled in the finished carton packaging. The inner folding carton and the outer folding carton consist of a joint carton blank or each consist of a separate carton blank or each consist of a plurality of carton blanks.
Patent TW-I404641-B (TW)
Title: Racing vehicle seat
Inventor: CHANG CHIA CHIEH
IPC: B60N2/90
Filed: 2008-11-10
Granted: 2013-08-11
Abstract: A racing vehicle seat and an acting method thereof are provided. The racing vehicle seat includes a body, at least a pressure sensor, at least a pneumatic bag, and a pneumatic bag control system. The pressure sensor is disposed on the body. The pneumatic bag is disposed in the body, and the pneumatic bag control system is connected with the pneumatic bag. The pressure sensor detects a loading applied on the body, and outputs a signal accordingly. The pneumatic bag control system receives the signal and replenishes or exhausts air of the pneumatic bag according to the signal.
Patent TW-I413355-B (TW)
IPC: H02M7/04
Filed: 2008-11-27
Granted: 2013-10-21
Abstract: A power adapter architecture is disclosed, the power adapter at least obtaining an AC input power and converting the same into a DC main output power. The power adapter comprises a power factor correction circuit for obtaining the AC input power and converting the same into a modulated power, an insulation step-down circuit connected with the power factor correction circuit for modulating and performing step-down on the modulated power to form a modulated step-down power, a switchable regulation circuit connected with insulation step-down circuit and obtaining the modulated step-down power, and a stabilization modulation circuit connected with the switchable regulation circuit. The switchable regulation circuit presets constant rating output level and modulates the modulated step-down power to the rating output level to form a rating power. The stabilization modulation circuit modulates the rating power to the main output power and supplies the main output power to a main output end.
Patent TW-I415438-B (TW)
Title: Portable electronic device
Inventor: WANG CHIH KUANG
IPC: H04M1/02
Filed: 2009-04-06
Granted: 2013-11-11
Abstract: A portable electronic device (100) includes a first body (110), a second body (120), a motion assembly (130), a connector (140), and an ejector (150). The second body has a hollow portion (122), and the first body is movable disposed on the second body to cover the hollow portion. The motion assembly is disposed between the first body and the second body, so that the first body is able to move relatively to the second body. The connector is movably disposed in the hollow portion. The ejector is disposed between the connector and the second body. When the first body moves relatively to the second body to expose the hollow portion of the second body, the ejector is capable of driving the connector to move out of the hollow portion.
Patent TW-I405198-B (TW)
Title: Data read-out system and method for current reduction
Inventor: HSIEH BING YU
IPC: G11B7/005
Filed: 2009-11-05
Granted: 2013-08-11
Abstract: The invention provides a method for current reduction for an analog circuit in a data read-out system. First, a performance indicator, indicating a performance of the data read-out system is generated. The performance indicator is then compared with a performance threshold level to generate a switch signal. A level of a current source biasing the analog circuit is then adjusted according to the switch signal.
Patent TW-I410621-B (TW)
Title: Trace detection device of biological and chemical analytes and diction method applying the same
Inventor: LIN DING ZHENG
IPC: G01N21/65
Filed: 2009-11-06
Granted: 2013-10-01
Abstract: Disclosed is a trace detection device of a biological and chemical analyte, including a metal substrate, a periodic metal nanostructure on the metallic substrate, a dielectric layer on the periodic metal nanostructure, and a continuous metal film on the dielectric layer. Tuning the thickness of the dielectric layer and/or the continuous metal film to meet the laser wavelength can shift the absorption peak wavelength of the sensor, thereby further enhancing the Raman signals of the analyte molecules.
Patent TW-I408345-B (TW)
Title: Adjustable standard low luminance device
Inventor: CHEN CHENG HSIEN
IPC: G01J1/10
Filed: 2009-12-10
Granted: 2013-09-11
Abstract: The present invention provides an adjustable standard low luminance device which utilizes a low illuminance light detector to detect the illuminance, transforms the detected illuminance into the luminance via a standard white board and then controls the output of the luminance through a luminance output regulator.
Patent TW-I396358-B (TW)
Title: Battery management systems,circuits for monitoring battery cells,and methods for managing battery cells
Inventor: KAO HAN JUNG
IPC: G01R31/36
Filed: 2009-12-18
Granted: 2013-05-11
Abstract: A battery management system (200A) with synchronized data sampling for a battery pack including multiple battery cells (2101,2102,...) is disclosed. The battery management system (200A) includes a plurality of local monitors (2081,2082,...) coupled to a plurality of battery cells (2101,2102,...) and operable for sampling status information for the battery cells. The battery management system (200A) further includes a central controller (214) coupled to the local monitors (2081,2082,...) and operable for broadcasting a sample command to the local monitor synchronously, wherein the local monitors start to sample the status information for the battery cells in response to the sample command.
Patent TW-I401269-B (TW)
Title: Epoxy resin composition, and prepreg and printed wiring board using the same
Inventor: CHEN HSIEN TE
IPC: C08G59/40
Filed: 2010-06-14
Granted: 2013-07-11
Abstract: Disclosed is an epoxy resin composition for printed circuit board, which includes (A) an epoxy resin; (B) a composite curing agent, including amino-triazine-novolac resin, diaminodiphenylsulfone, and dicyandiamide mixed in a certain proportion; (C) a curing accelerator; and (D) an optional inorganic filler.
Patent TW-I414527-B (TW)
Title: Isosorbide derivatives and liquid crystal displays comprising the same
Inventor: WU CHUN MING
IPC: C07D493/04
Filed: 2010-10-06
Granted: 2013-11-11
Abstract: An isosorbide derivative of Formula (I) is provided. In Formula (I), Z is —CH2—CH2—, —CH═CH—, —C≡C—, —CH2—O—, —CH2—S—, —CH═N—O—, —CO—O—, —CO—S—, single bond, -ph-, —CO—O-ph- or —CO—O-ph-CO—O—, and ph represents benzene, R1 and R2 are, independently, C1-25 alkyl, —CN, —NCS, —CX3 or —OCX3, and X represents halogen, and m and n are, independently, 0, 1 or 2. The invention also provides a liquid crystal display including the isosorbide derivative.
Patent GB-2486789-B (GB)
Title: Wading vehicle advisory speed display
Inventor: TRAN THUY-YUNG
IPC: G01S15/931
Filed: 2011-12-15
Granted: 2013-06-12
Abstract: A wading vehicle (100) having a water level sensor (114) comprising a hydrostatic pressure sensor.
Patent GB-2492008-B (GB)
Title: Shredder and gauging device arrangement
Inventor: ARIES PAUL ARTHUR
IPC: B02C18/00
Filed: 2007-08-02
Granted: 2013-02-06
Abstract: A shredding machine for domestic or office use having a feed passage 3 leading to a cutting mechanism 10, 11 powered by an electric motor 19, has a thickness measuring /gauging device 15 for measuring the thickness of bundles of paper fed through the feed passage 3 and the machine is controlled by a microprocessor which receives signals from the thickness measuring device 15 and prevents the cutting mechanism 10, 11 from being energised if the thickness measured is above a threshold determined by the microprocessor. Device 15 may be deactivated during shredding (see figure 8 stages 441 and 443) so that any paper which ripples or flaps during shredding within passage 3 does not cause arm 17 or probe 300 (figure 6) to move and thereby cause false thickness readings. Furthermore, the microprocessor varies the threshold in accordance with a sensed variable parameter such as electrical supply voltage, the electric motor temperature and the electric current drawn by the motor during a previous shredding operation, so that the maximum thickness the shredder will accept can be reduced automatically when motor temperature increases or as the effectiveness of the machine deteriorates throughout its working life.
Patent GR-7531-B (GR)
Title: Μεθοδος τη βοηθεια σπαθιδος (σπατουλας) η ψεκαστηρος προς αποκτησιν μιας τοιχωδους επενδυσεως, δυναμενη να πλυνεται και ν' αντεχη εις τας καιρικας μεταβολας, εις το φως, το ψυχος και τας αλυσιβας εχουσης οψιν ομοιαζουσα προς ασβεστολιθον κοχλιοφορονη ..
Inventor: BODE HANS
Filed: 1938-06-06
Abstract: έθοδος εις μαχαίριον ή έις πιστόλιον δια την απόκτησιν ενός στρώματος τοιχοειδούς και δυνάμενο να πλυθή, δυναμένου να αντέχει εις δυσκρασίας εις το φως, εις την ψύξη εις αλισίβας και ομοιαζούσης εις μίαν όψιν παρομοιάζουσα εις το ασβεστούχο κοχυλοειδές ή υπολείμματα ασβεστούχων ειδών, χαρακτηρισθείσης δια του γεγονότος ότι μία ακριβές ανάμιξης τσιμέντου, λεπτής άμμου, φθορίου αμιάντόυ, ερίου, υάλου, ή σκωριάς, μεταλλευμάτων (οξοδίου)μερικά έλαιακαι ύδατος εφαρμόζονται εις παχέα ανώμαλα στρώματα ένα αντέχοντα πυθμένα, χαλίκια οξιδίου διαφόρου χρώματος ή ορυκτά μεταλλεύματα διαφόρων κοκκων, ή ασβεστούχα χαλίκια ή ακόμη η χρησιμοποίησα μάζα δια την κατασκευή του ρηθέντος επιχρίσματος, πλήν διαφόρους χρωματισμένων προβαλλόμενης κατόπιν ή είταεφαρμοζόμενης, σύμφωνος ενός ορισμένου σχεδίου ή πρωτοτύπου. Δια να δύσωμεν εις το σκληρυνθέν επίχρισμα μία όψιν ομοιάζουσα της των ασβεστούχων ειδών, προστρίβεται η επιφάνεια και λειαίνεται κατά τονγνωστό τρόπο ή προστρίβετε και επενδύεται δι' επιχρίσματος αχρού εκ φθορίου ή τεχνητών ρητινών.
Patent GR-19124-B (GR)
Title: Μεθοδος παρασκευης αμινων παραγωγων της διμεθυλο - σουλφανιδο - 3 - φαινοθειαζινης υποκατεστημενων.
Filed: 1957-06-17
Abstract: παρούσα εφεύρεσις αφορά εις:
1. Εν τη ιδιότητί των ως νέων βιομηχανικών προϊόντων:
α. τα παράγωγα της φαινοθειαζίνης του γενικού τύπου:
[*]
εις τον οποίον το Υ παριστά άτομον θείου ή ρίζαν SO ή SO2,το Ζ μονο- ή διαλκαλαμινομάδα, εις ήν τ' αλκύλια περιέχουν 1 έως 5 άτομα άνθρακος, ή ρίζαν κακλικήςαμίνης, ουχί αρωματικής και το Α δισθενή ρίζαν αλειφατικού υδρογονάνθρακος με άλυσσον ευθείαν ή διακεκλαδισμένην ενέχουσαν 2 έως 5 άτομα άνθρακος, υποκατεστημένην ή μη υπό ρίζης -Β-Ζ', όπου το Βπαριστά απλούν δεσμόν ή μεθυλένιον και το Ζ' εκλέγεται από την ίδιαν ομάδα σωμάτων εις ήν ανήκει και το Ζ, τα δε άτομα αζώτου του φαινοθειαζινυκού πυρήνος και του Ζ χωρίζονται μετξύ των υπό δύο τουλάχιστονατόμων άνθρακος.
β. τα άλατα και τα παράγωγα της τεταρτοταγούς αμμωνιοβάσεως των παραγώγων της φαινοθειαζίνης της αξιώσεως α.
2. Την παρασκευήν των παραγώγων της αξιώσεως 1 α δια μιας των επομένων μεθόδων:
α. Δι' επιδράσεως επί της καταλλήλου διμεθυλοσουλφαμιδο-3 φαινοθειαζίνης εστέρος αμιναλκοόληςΧ-Α-Ζ (Χ-άτομον αλογόνου ή ρίζα θειϊκού ή σουλφονικού εστέρος).
β. Δι' επιδράσεως αμίνης Η-Ζ επί εστέρος του γενικού τύπου:
[*]
Patent GR-23219-B (GR)
Title: Βελτιωσεις εις η εν σχεσει προς την παραγωγην ενωσεων τετρακυκλινης.
Inventor: HLAVKA JOSEPH JOHN
Filed: 1962-03-13
Abstract: ία μέθοδος παρασκευής μιας ενώσεως του γενικού τύπου:
[*]
και των μη τοξικών, δια προσθήκης οξέων αλάτων αυτών, ένθα, εις τον ανωτέρω τύπον, τα R1 και R2 είναι υδρογόνον, ρίζαι αζιδο, κατώτεραι αλκανοϋλοξύρίζαι, αλογονο-αλκανοϋλοξύ-ρίζαι και κατώτεραι αλκοξυθειοκαρβονυλοθειο-ρίζαι, υπό τον όρον ότιαμφότερα δεν δύνανται να είναι υδρογόνον και το R3 είναι υδρογόνον ή μεθύλιον, χαρακτηριζομένη εκ τούτου, ότι φέρομεν την αντίστοιχον μετά διαζωνίου ένωσιν της 6-δεοξυτετρακυκλίνης εις αντίδρασιν με μίαν ένωσιν ήτις ελευθερώνει υδραζωϊκόν οξύ, εν κατώτερον αλκυλο-ξυνθικόν οξύ, εν κατώτερον κεκορεσμένον αλειφατικόν καρβοξυλικόν οξύ ή εν κατώτερον αλογονο-αλκυλοκαρβοξυλικόν οξύ.
Patent GR-37150-B (GR)
Title: Μεθοδος δια την παρασκευην ενος 9β, 10α - στεροειδους.
Filed: 1967-05-16
Abstract: έθοδος δια την παρασκευήν 17α-μεθυλ-9β, 10α-πρεγν-4-εν-3, 20-διόνης χαρακτηριζομένη εκ του ότι μεθυλιούμεν αναγωγικώς την 9β, 10α-πρεγνα-4, 16-διεν-3, 20-διόνην προστατεύοντες (συγχρόνως) την 3-κετοομάδα και εκ του προϊόντος της αντιδράσεως αποσπώμεν την προστατευτικήν ομάδα.
Patent GR-74047-B (GR)
IPC: E03F3/04
Filed: 1979-12-03
Abstract: PCT No. PCT/SE79/00245 Sec. 371 Date Jul. 25, 1980 Sec. 102(e) Date Jul. 25, 1980 PCT Filed Dec. 3, 1979 PCT Pub. No. WO80/01180 PCT Pub. Date Jun. 12, 1980.A drain pipe consisting of an outer pipe casing, which downwardly or on the lower surface is provided in the longitudinal direction with a recess, from which two partition walls extend upward and are connected at the upper end to the inside of the pipe casing via extensions of the partition walls resembling inclined roofs. In the inclined roof shaped extensions, which are connected in a line at the inside of the pipe casing, overflow openings are milled in a single operation.
Patent GR-862698-B (GR)
Title: Cephalosporin derivatives and method for preparing them
Inventor: RUDOLF LATTRELL DR
IPC: C07D501/46
Filed: 1986-11-10
Abstract: Cephalosporin derivatives of the formula <IMAGE> pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the production of the pharmaceutical preparations and use of the cephem derivatives for combating bacterial infections.
Patent GR-1000483-B (GR)
Inventor: BENIGNI A DANIEL
IPC: C07H19/16
Filed: 1988-07-08
Abstract: Αποκαλύπτεται νέα μέθοδος για να παράγεται εκλεκτικά β-2, 3-διδεοξυϊνοσίνη σε υψηλές αποδόσεις.  Η β-2, 3- διδεοξυϊνοσίνη που παράγεται με τον τρόπο αυτό είναι χρήσιμη σαν αντιϊογενής και αντιβιοτικός παράγων. ω
Patent GR-1001911-B (GR)
Title: Visually clear gel dentifrice.
Inventor: COLLINS MICHAEL ALAN
IPC: A61K8/81
Filed: 1992-12-18
Abstract: A visually clear gel dentifrice comprising a polishing agent having a refractive index of about 1.41 to 1.47, a water-swellable synthetic anionic polycarboxylate polymer and a liquid vehicle of about 25-30% by weight water and 30-45% by weight of neat humectant wherein at least about 30% by weight of said dentifrice is neat sorbitol.
Patent IN-167606-B (IN)
Inventor: HIDEKI MIKI
IPC: C07D521/00
Filed: 1988-08-22
Abstract: This invention relates to a process for producing a compound of the formula (I) as shown below. <CHEM> wherein Q is a condensed heterocyclic group having a nitrogen atom in the bridgehead position which may optionally be substituted, R1 and R2 each are an alkyl group, an alkoxy group or halogen and Z is CH or N, or a salt thereof. The compound (I) or a salt thereof is novel and of value as agricultural chemicals. According to the process of this invention the compound (I) or a salt thereof can be produced in good yield and high purity.
Patent IN-155013-B (IN)
Inventor: MANTELLE JEAN
IPC: F16L15/00
Filed: 1980-11-24
Abstract: A joint for pipes in which externally threaded male members are screwed into an internally threaded sleeve. The ends of the male members have sealing surfaces thereon and are substantially cylindrical and thread-free. The ends are so formed that upon abutment they will be urged radially outwardly. The threaded sleeve has a substantially thread-free cylindrical sealing surface intermediate its ends. When the male members are screwed into the sleeve the ends abut causing the sealing surfaces of the male members to be forced radially outwardly into tighter sealing engagement with the sealing surface of the sleeve.
Patent RS-51891-B (RS)
Inventor: BOUZIDA DJAMAL
IPC: A61K31/437
Filed: 2005-12-28
Abstract: PIROLOPIRAZOLI, POTENTNI INHIBITORI KINAZE. Jedinjenje formule I.naznačeno time što:R1 je izabran od 5-12 člane heteroaril i 5-12 člane heteroaril grupe supstituisane sa 1 do 6 R5, pri čemu bilo koja dva susedna R5, zajedno sa atomima za koje su vezani, mogu da formiraju spojeni 4-7 člani prsten, a ovaj spojeni prstenje opciono dalje supstituisan sa 1-3 Rf;R2 i R3 su svaki nezavisno izabrani od -H, C1-C6 perfluoroalkil, C1-C6 alkil, C3-C8 cikloalkil, -(C1-C3 alkilen)-(C3-C6 cikloalkil), C2-C6 alkenil, C2-C6 alkinil, C1-C6 alkoksi, -(L)m-halid, -(L)m-CN, -(L)m-OH, -(L)m-NH2, -(L)m-(C1-C6 monoalkilamino) i -(L)m-(C2-C8 dialkilamino) grupe, pod uslovom da Rx i R3 nisu oba H; ili R2 i R3 mogu da formiraju prsten izabran od C3-C8 cikloalkil, C4-C8 cikloalkenil i 3-6 članog heterociklil prstena, ovaj prstenje dalje supstituisan sa 1 do 2 grupe izabrane od C1-C3 alkil, C1-C3 perfluoroalkil, C1-C3 alkoksi, okso, -(C1-C3 alkilen)m-halid, -(C1-C3 -alkilen)m-CN, -(C1-C3 alkilen)m-OH, -(C1-C3 alkilen)m-NH2, -C1-C3 alkilen)m-(C1-C8 monoalkilamino) and-(C1-C3 alkilen)m-(C2-C8 dialkilamino) grupe; R4 je izabran od Ra, -C(O)Ra, -C(O)NRaRb, -C(O)ORa, -C (O)CH(Rt)Ra, -C (O)NHCH(Ra)Rb,-C (O)OCH(Ra) Rb, -C(O)CH(Rj)CH(Ra)Rb, -C(O)SRa, -S (O)Ra, -S (O)NRaRb, -S(O)ORa, -S(O)2Ra, - S (O)2NRaRb i -S  (O)2ORa grupe, pri čemu je Rl H ili C1-C3 alkil grupa;svaki R6 je nezavisno izabran od Rc, -(L)m-halid, -(L)m-CN, -(L)m-C (O)Rc, -(L)m-C (O)ORc, - L)m-C(O) NRcRd, -(L)m-C (O)SRc, -(L)m-ORc, -(L)m-OC (O)Rc, -(L)m-OC (O)NRcRd, -(L)m-O-C(O)ORc, -(L)mNO2, -(L)m-NRcRd, -(L)m-N(Rc)C (O)Rd, -(L)m-N(Rc)C(O)ORd, -(L)m-NRcS (O)Rd, -(L)m-NRcS (O)ORd, -(L)m-NRcS (O)2Rd, -(L)m-NRcS (O);ORd, -(L)m-SRC, -(L)m-S (O)Rc, -(L)m-S (O)ORc, -(L)m-S (O)2RC, -(L)m-S (O)2ORc. -(L)m-S (O)NRcRd, -(L)m-S (O)2NRcRd, -(L)m-O-L-NRcRd, -(L)m-O-L-ORc i -(L)m-NRc-L-ORd grupe;svaki Ra, Rb, Rc i Rd je nezavisno izabran od H, -(L)m-(C1-C6 perfluoroalkil), C1-C12 alkil, -(C1-C3 alkilen)m-(C3-C12 cikloalkil), -(C3-C5 cikloalkilen)m-(C2-C12 alkenil), -(L)m-(C4-C12 cikloalkenil), -(C3-C5 cikloalkilen)m-(C2-C12 alkinil), -(L)m-(3-12 člani heterociklil), -(L)m-(C6-C10 aril) i -(L)m-(5-12 člane heteroaril) grupe, svaki Ra, Rb, Rc i Rd je nezavisno opciono dalje supstituisan sa 1-6 Rf; Ra i Rb, ili Rc i Rd, zajedno sa atomom za koji su vezani, mogu opciono da formiraju prsten izabran od 3-12 članog heterociklil i 5-12 članog heteroaril prstena, ovaj prstenje dalje supstituisan sa 1-6 Rf; svaki R je nezavisno izabran od okso, -(C1-C3 alkilen)m-( C1-C6 perfluoroalkil), C1-C12 alkil, C2-C6 alkenil, C2-C6 alkinil, -(C1-C3 alkilen)m-(C3-C7 cikloalkil), -(C1-C3 alkilen)m-(3-7 člane heterociklil), -(C1-C3 alkilen)m-(5-7 člane heteroaril),-(L)m-halid, -(L)m-CN, -(L)m-C (O)Rk, -(L)m-C (O)ORk, -(L)m-C (O) NRkRJ, -(L)m-ORk, -(L)m-OC (O)Rk, -(L)m-NO2, -(L)m-NRkRj, -(L)m-N(Rk)C (O)Rk -(L)m-O-L-NRkRj, -(L)m-SRk, -(L)m-S (O)Rk, -(L)m-S (
Patent RS-53406-B (RS)
Inventor: MENET CHRISTEL JEANNE MARIE
IPC: C07D471/04
Filed: 2009-07-24
Abstract: Jedinjenje prema Formuli III:naznačeno time štoL1 je izabran od jednostruke veze. -O-, -N(R4a)-, -C(O)-, C$=N(R4a)]-, -CON(R4a)-. -SO2N(R4a)-, -S(O)2-, -N(R4a)SO2- i -N(R4a)CO-; n1 je 0, 1, 2, 3, ili 4; i R3b je supstituisan ili nesupstituisan C6-10 aril, supstituisan ili nesupstituisan 5-10 člani heteroaril koji sadrži 1 do 3 heteroatoma izabrana od N, O, ili S, supstituisan ili nesupstituisan C3-C7 cikloalkil, supstituisan ili nesupstituisan 4-7 člani heterocikloalkil koji sadrži 1 do 3 heteroatoma izabrana od N, O, ili S,R4a je H, supstituisan ili nesupstituisan C1-C4 alkil, supstituisan ili nesupstituisan C1-C4 alkoksi,pri čemu su supstituenti za izraz "supstituisan" u definiciji R3b, i R4a izabrani iz grupe koja sadrži:halo, cijano, nitro, trifluorometil, trifluorometoksi, azido, -NR'"SO2R, -SO2NR"R", -C(O)R",-C(O)OR", -OC(O)R", -NR"'C(O)R", -C(O)NR"R'", -NR'R'", -(CR"'R"')mOR"', pri čemu, svaki R" je nezavisno izabran od H, C1-C8 alkil, -(CH2)t(C6-C10 aril), -(CH2)t(5-10 člani heteroaril koji sadrži 1 do 3 heteroatoma izabrana od N, O, ili S), -(CH2), (C3-C10 cikloalkil), i -(CH2)t(4-10 člani heterocikloalkil koji sadrži 1 do 3 heteroatoma izabrana od N, O, ili S), pri čemu t je celi broj od 0 do 4; i- bilo koje alkil grupe koje su prisutne, mogu i same biti supstituisane sa halo ili hidroksi; i- bilo koje aril, heteroaril, cikloalkil ili heterocikloalkil grupe koje su prisutne, mogu i same biti supstituisane s nesupstituisanim C1-C4 alkilom, halo, nesupstituisanim C1-C4 alkoksi. nesupstituisanim C1-C4 haloalkilom, nesupstituisanim C1-C4 hidroksialkilom, ili nesupstituisanim C1-C4 haloalkoksi ili hidroksilom;svaki R'" nezavisno predstavlja H ili C1-C6alkil; i uz uslov da i) kada L1 je -O-, -N(R4)-, -CON(R4a)-, ili -SO2N(R4a)-, i R3b je različit od cikloalkila, arila ili 5-10 članog heteroarila, tada n1 je 1, 2, 3, ili 4;ili njihova farmaceutski prihvatljiva so, za upotrebu za lečenje i/ili sprečavanje- reumatoidnog artritisa, osteoartritisa, alergijskih bolesti disajnih putova, inflamatornih bolesti creva- hronične opstruktivne plućne bolesti, astme, sistemskog eritemskog lupusa- Castlemanove bolesti ili mezangijskog proliferativnog glomerulonefritisa endotoksinom pokretanih bolesnih stanja, bolesti koje uključuju pogoršanje promjena u hrskavici, kongenitalnih malformacija hrskavice, te odbacivanja transplantata.Prijava sadrži još 10 patentnih zahteva.