Patent SG-11201908880W-A (SG)
Title: MODELING miRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM
Inventor: SEDGEWICK ANDREW
IPC: G16B45/00
Filed: 2018-03-27
Abstract: logrank p., xz 71' co 00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) Wi P 0 I PCT IiiimmomiolollmonolomoninooliolionoiommIE (10) International Publication Number WO 2018/183363 A4 (51) International Patent Classification: C07K 14/47 (2006.01) GOOF 19/12 (2011.01) C12Q 1/68 (2018.01) GOOF 19/18 (2011.01) G01N 33/48 (2006.01) GOOF 19/26 (2011.01) GOOF 19/10 (2011.01) (21) International Application Number: PCT/US2018/024615 (22) International Filing Date: 27 March 2018 (27.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/477,929 28 March 2017 (28.03.2017) US (71) Applicants: NANTOMICS, LLC [US/US]; 9920 Jeffer- son Boulevard, Culver City, California 90232 (US). NANT HOLDINGS IP, LLC [US/US]; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (72) Inventors: SEDGEWICK, Andrew; 9920 Jeffer- son Boulevard, Culver City, California 90232 (US). RABIZADEH, Shahrooz; 9920 Jefferson Boulevard, Culver City, California 90232 (US). SOON-SHIONG, Patrick; 9920 Jefferson Boulevard, Culver City, Califor- nia 90232 (US). VASKE, Charles Joseph; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (74) Agent: FESSENMAIER, Martin et al.; UMBERG ZIPSER LLP, 1920 Main Street, Suite 750, Irvine, Califor- nia 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: MODELING miRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM Time Figure 4 (57) : A probabilistic graphical pathway model is modified to include miRNA regulation by adding RISC as a regulatory factor. Most preferably, the pathway model is built using factor graphs, and the RISC includes DICER, TARBP2, and AGO2 or AGO1/3/4. So constructed pathway models can be used to infer RISC activity, which can be associated with various clinically relevant parameters to build various predictors or diagnostic tests. [Continued on next page] WO 2018/183363 A4 MIDEDIMOMOIDEIREEM31111010011011001MION TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with amended claims (Art. 19(1)) Date of publication of the amended claims: 08 November 2018 (08.11.2018)