baber/WOPTO huggingface dataset:
Patent CA-2198470-A1 (CA)
Title: Luciferase labelling method
Inventor: SQUIRRELL DAVID JAMES
IPC: C12Q1/68
Filed: 1995-08-30
Abstract: A method is provided for conjugating luciferase to a chemical entity, particularly to a specific binding agent such as m antibody, antigen or a nucleic acid, and more particularly an antibody, comprising (a) mixing the luciferase with one or more of D-luciferin, magnesium ions and adenosine triphosphate and (b) performing a covalent coupling reaction between the luciferase and the binding reagent using a covalent coupling reagent wherein the amount of D-luciferin, magnesium ions and/or adenosine triphosphate is sufficient to protect the luciferase activity against inhibition by the covalent coupling reagent.  Preferably the step (a) is carried out by mixing the luciferase with its substrates in solution and preferably both magnesium and adenosine triphosphate are present as magnesium adenosine triphosphate (Mg2+ATP), optionally together with D-luciferin. In a second aspect of the invention there is provided a labelled chemical entity comprising a chemical entity conjugated to active luciferase as provided by the method of the present invention. Preferably the chemical entity is a specific binding agent suitable for use in a specific binding assay, preferably being an antibody, antigen or nucleic acid. When the binding agent is a nucleic acid, it is preferably an oligonucleotide, but may be a polynucleotide or a nucleoside, and may be used as a hybridisation probe or a chain extension primer e.g. a PCR primer. Most advantageously the entity is an antibody as previous attempts to couple antibodies to luciferase have resulted in inactivity. Test kits are further provided.
Patent CA-2198815-A1 (CA)
Title: Process for the separation of high-boiling materials from the reaction mixture generated during the production of diaminotoluene
Inventor: WITT HARRO
IPC: C07C209/84
Filed: 1997-02-28
Abstract: Amine mixtures generated during the production of diaminotoluene by hydrogenating dinitrated aromatic compounds are treated to separate high boiling materials from the desired amine products. In this process, any water of reaction and any solvent are first removed from the diaminotoluene isomer mixture (TDA mixture). The low-boiling TDA isomers are then separated using a TDA isomer distillation column. In the process of the present invention, the bottom phase remaining after the initial distillation contains a mixture of m-TDA and high-boiling materials. This bottom phase is separated and concentrated until the high-boiling material content is from approximately 25 to 60 wt.%. This concentrated bottom phase is then mixed with o-TDA in a ratio of 1:1 to 1:5 and a m-/o-TDA mixture is removed by distillation. The m-/o-TDA mixture thus recovered is then returned to the TDA isomer distillation column.
Patent CA-2200243-A1 (CA)
Title: Method for producing highly active, stable metallocene catalyst systems,and formulations produced thereby
Inventor: RIEGER RAINER
IPC: C08F4/6592
Filed: 1997-03-18
Abstract: Disclosed are a method for the production of homogeneous, highly active, stable formulations, consisting essentially of one or more organometallic catalyst components in paraffins, and formulations produced according to this method.
Patent CA-2203440-A1 (CA)
Title: Device for tilting the top end and/or bottom end of a bed
Inventor: NEIGE JEAN-FRANCOIS
IPC: A47C20/04
Filed: 1995-10-24
Abstract: A device for tilting the top end and/or bottom end of a bed, including two hingedly connected frames and a control unit operably connected thereto for adjusting the spacing therebetween, wherein one, fixed frame is supported on the bed base while the other, movable frame supports one end of a mattress. The fixed frame comprises two parallel coplanar tubes (109) and the movable frame consists of a U-shaped frame (105) pivotably mounted on and between said tubes (109). Said control unit is attached to the fixed frame and controls the longitudinal translation of slide blocks (110) by means of worm screws (111), said blocks being slidable along said tubes (109) to tilt the movable frame relative to the fixed frame. The worm screws (111) are mounted in said two tubes (109) and the control unit is located outside the area encompassed by the fixed frame.
Patent CA-2203657-A1 (CA)
Title: Center masking illumination system and method
Inventor: GREENBERG GARY
IPC: G02B21/08
Filed: 1995-10-23
Abstract: Methods and apparatus for center masking a condenser lens of a transmitted light microscope to simultaneously maximize resolution, contrast and depth of field utilizing at a conjugate plane of the aperture plane where an image of the rear aperture of the condenser lens has been created, a plurality of light sources to illuminate two or more of the faces of a multi-face mirror in the shape of a pyramid which moves relative to the light sources to vary the amount of center masking continuously over a range including zero while directing multiple oblique beams of light onto the objective lens.
Patent CA-2204936-A1 (CA)
Title: Catalyst for powder coatings
Inventor: EKLUND WAYNE G
IPC: C08G59/68
Filed: 1997-05-09
Abstract: A powder coating composition prepared by combining components comprising a bisphenol A epoxy resin, a carboxylic acid-functional polyester compound, and a catalytic salt prepared from a mono- or di-carboxylic acid having at least one acid group with a pKa greater than about 2.9 and an amount of an imidazoline-based compound sufficient to react with the acid group having a pKa greater than about 2.9 and further, a powder coating composition prepared by combining components comprising, triglycidyl isocyanurate; a carboxylic acid-functional polyester compound; and a catalytic salt of a mono- or di-carboxylic acid having at least one acid group with a pKa greater than about 2.9 and an amount of an imidazoline-based compound sufficient to react with the acid group having a pKa greater than about 2.9.
Patent CA-2208161-A1 (CA)
Title: Method for the manufacture of a roll for use in the production of paper, roll for use in the production of paper, and coating for a roll for use in the production of paper
Inventor: TELAMA ARI
IPC: C23C4/11
Filed: 1996-10-17
Abstract: A roll for use in the production of paper having a frame and a roll coating produced by thermal spraying. The coating is sealed by crystals formed out of a sealing-agent solution after the elimination of water therefrom. A coating for a roll for use in the production of paper produced by thermal spraying and having pores. In order to seal the coating, a sealing agent is crystallized in the pores in the coating.
Patent CA-2209704-A1 (CA)
Title: Printable heat transfer material having cold release properties
Inventor: KRONZER FRANCIS JOSEPH
IPC: B41M5/42
Filed: 1997-07-11
Abstract: A printable heat transfer material having cold release properties, which material includes a flexible first layer having first and second surfaces. The first layer typically will be a film or a cellulosic nonwoven web. A second layer overlays the first surface of the first layer and includes a thermoplastic polymer, such as a hard acrylic polymer or a poly(vinyl acetate). A third layer overlays the second layer and includes a thermoplastic polymer which melts in a range of from about 65°C to about 180°C. The first layer may be a cellulosic nonwoven web, such as a latex-impregnated paper. The thermoplastic polymer of which the second layer is composed may have a glass transition temperature of at least about 25°C. The second layer also may include an effective amount of a release-enhancing additive, such as a divalent metal ion salt of a fatty acid, a polyethylene glycol, or a mixture thereof. The third layer may include a film-forming binder, which binder may include a powdered thermoplastic polymer. For an ink jet printable heat transfer material, a fourth layer may overlay the third layer, which fourth layer includes a film-forming binder and a powdered thermoplastic polymer. If desired, a fifth layer may overlay the second layer, thereby being located between the second layer and the third layer. The fifth layer may include a film-forming binder which melts in a range of from about 65°C to about 180°C.
Patent CA-2210169-A1 (CA)
Title: Composition comprenant l'association d'un compose volatil et d'un copolymere de polyvinylpyrrolidone et d'alpha-olefines, et utilisation de ladite association
Inventor: ARNAUD PASCAL
IPC: A61K8/00
Filed: 1997-07-16
Abstract: La présente demande concerne une composition cosmétique, dermatologique, hygiéni que et/ou pharmaceutique, sans transfert, comprenant un composé volatif et un polymè re dérivé de polyvinylpyrrolidone. L'invention concerne également l'utilisation de cette association pour limiter, diminuer et/ou supprimer le transfert et/ou la migration de ladite composition.
Patent CA-2210230-A1 (CA)
Title: Process for preparing alkyl tertiary-alkyl ether
Inventor: SIMONS THEODOOR JOHAN LEONARD
IPC: C07C43/04
Filed: 1996-01-11
Abstract: The invention relates to a process for preparing an alkyl tertiary-alkyl ether b y (a) feeding an iso-olefin reagent-containing stream and an alcohol reagent via inlet (11) to reactor (1) and allowing these reagents to react under etherification conditions to form an alkyl tertiary-alkyl ether-containing reaction mixture, (b) passing the reaction mixtu re produced in (a) via pipe (12) and a hydrocarbon feed stream via inlet (21) to distillation column (2), (c) fractionating the reaction mixture and hydrocarbons to obtain a stream comprising alkyl tertiary-alkyl ether at outlet (24) at the bottom of the distillation column (2) and a stream comprising alcohol and hydrocarbons at outlet (22) at the top of the distillation column (2), and (d) recycling at least part of the overhead mixture obtained at outlet (22) to the reactor (1), wherein the hydrocarbon feed stream comprises iso-olefin reagent, and where in at least part of the iso-olefin reagent-containing stream supplied into the reactor is formed by the overhead mixture.
Patent CA-2210594-A1 (CA)
Title: Attachment system for mounting road-maintenance equipment on a vehicle
Inventor: MCMILLAN PERRY DARRELL
IPC: E02F9/00
Filed: 1997-07-16
Abstract: An attachment system for mounting road-maintenance equipment on a vehicle such as a motor grader includes a frame for mounting on the nose plateof the vehicle to support the conditioning equipment forwardly and partly outboard of the vehicle.  The system includes pivotal attachment mounts for the front andrear ends of a draft frame of the conditioning equipment together with a strut for supporting the draft frame at a desired orientation during operation, and for raising the draft frame and surface conditioning equipment to a retracted position when not in use.  A mast on the attachment system frame directs a cable to the rear end of the draft frame to effect raising movement of the latter to the transportposition.
Patent CA-2211521-A1 (CA)
Title: Novel paroxetine hydrochlorine anhydrate forms
Inventor: JACEWICZ VICTOR WITOLD
IPC: A61K31/445
Filed: 1996-02-05
Abstract: The present invention relates to paroxetine hydrochloride anhydrate substantially free of bound propan-2-ol, several forms of the above, processes for preparing the above, new intermediates useful in preparing the above and methods of treating and/or preventing certain diseases by administering the compounds of the invention to a sufferer in need thereof.
Patent CA-2213029-A1 (CA)
Title: System architecture for television information services
Inventor: SODHI ERICK
IPC: H04N7/16
Filed: 1997-08-14
Abstract: A system architecture for television information services includes screen elements for defining what appears in each area of a television screen, a screen layout editor for allowing an operator to create templates defining the location and attributes of the screen elements, a scheduler for allowing an operator to schedule the use of the templates, and a renderer for executing a schedule.   The system architecture provides the means for information service operators to streamline the implementation and management of their television information services.
Patent CA-2218805-A1 (CA)
Title: Passenger, baggage, and cargo reconciliation system
Inventor: SHOBER R ANTHONY
IPC: G07B15/04
Filed: 1997-10-21
Abstract: In accordance with the present invention, a radio frequency identification system, using modulated backscatter radio communications, is disclosed which supports the automated reconciliation of passengers, baggage, and cargo on a transport. A baggage tag is attached to each piece of checked baggage, where the baggage tag is a read-only tag with modulated backscatter radio capability. Thus, each piece of checked baggage can be identified for sortation, and also identified to ascertain if it has been loaded onto a particular aircraft. Pieces of baggage can be either loaded directly onto an aircraft, or loaded onto a cargo container; where a cargo tag is attached to the cargo container, the cargo tag is a read-write tag with modulated backscatter radio capability. The aircraft itself may be equipped with aircraft tags, which could be read-only or read-write tags withmodulated backscatter radio capability. Aircraft tags allow a positive association between the identity of the baggage or cargo container being loaded, the aircraft on which it is being loaded, and the cargo bay doorway through which it is being loaded. To identify passengers, several alternatives are disclosed. In one embodiment, a magnetic boarding pass can be used with a magnetic stripe containing information about this passenger. In this embodiment, the passenger is responsible for inserting the magnetic boarding pass into a magnetic card reader as the passenger boards the flight. In another embodiment, a radio boarding pass could be used. The radio boarding pass resembles a conventional boarding pass, however it has read-only modulated backscatter radio capability, perhaps identical with the technology used for the baggage tag. The radio boarding pass can be read as the passenger boards the aircraft. In an alternate embodiment, the passenger can have a passenger card, which is a read-write tag with modulated backscatter capability. The passenger card can be read as the passenger boards the aircraft, to identify the passenger. Alternately, the passenger card can be used for a number of enhanced passenger service applications in a generalized transportation environment.
Patent CA-2219646-A1 (CA)
Title: Falling film evaporator with vapor-liquid separator
Inventor: SANBORN DUANE F
IPC: F25B39/02
Filed: 1996-04-22
Abstract: Compression refrigeration apparatus (1) for removing heat from a heat load using a falling film evaporator (8), operated with an azeotropic refrigerant and utilizing a vapor-liquid separator (35), preferably inside the evaporator vessel (47). In one embodiment, two types of heat exchange surfaces (38) are utilized: one (68) for maximizing the axial distribution of refrigerant film on a heat exchange surface; the other (69) for encouraging liquid refrigerant in contact with a heat exchange surface to boil and evaporate. The apparatus allows for efficient recovery of lubricant deposited in the evaporator (8) without redistributing the lubricant within the evaporator (8).
Patent CA-2221662-A1 (CA)
Title: Connecting cable, communication device and communication method
Inventor: YOSHINO KAZUO
IPC: H01R13/719
Filed: 1997-11-20
Abstract: In a 6-pin cable according to an IEEE-1394 standard, power lines and two pairs of signal conductors are built and connected to a head part provided with six electric joints not shown corresponding to six conductors (total six consisting of two power lines and total four signal conductors). Ferrite beads respectively forming a closed magnetic circuit around the signal conductors are respectively provided to the signal conductors of the 6-pin cable. As a result, crosstalk between the signal conductors in a common mode is inhibited.
Patent CA-2222296-A1 (CA)
Inventor: DEIGIN VLADISLAV ISAKOVICH
IPC: A61K38/08
Filed: 1996-05-06
Abstract: The invention pertains to medicine, specifically to methods of obtaining biologically active substances with immunoregulatory properties, and can be used in medicine, veterinary science and experimental biochemistry. The problem addressed by the invention is that of producing a novel synthetic biologically active peptide with immunoregulatory properties of formula X-A-D-Trp-Y, in which A is D-Glu, iD-GLu; X is H or Gly, Ala, Leu, Ile, Val, Nval, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, DTrp, .gamma.-aminobutyric acid, -aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, Nval, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, DTyr, D-Phe, D-Trp, .gamma.-aminobutyric acid, -aminocaproic acid, -OH or substituted amide (C1-C3). The method of producing the peptide involves the synthesis of glutamil-containing peptides in solution by scission of an internal anhydride of tributyloxycarbonyl glutamic (D or L) acid with the appropriate k-salt of D-Trp-Y. This is followed by chromatographic separation of the .alpha.- and .gamma. isomers. Further synthesis was carried out by building up a peptide chain using activated esters of tributyloxycarbonylamino acids.
Patent CA-2222706-A1 (CA)
Title: Radiation treatment of the vascular system
Inventor: HALPERN DAVID S
IPC: A61F2/958
Filed: 1997-04-04
Abstract: Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.
Patent CA-2225406-A1 (CA)
Title: Techniques de traitement et de prevention du diabete
Inventor: GAUR AMITABH
IPC: C07K14/47
Filed: 1996-06-24
Abstract: La présente invention décrit des peptides et des analogues de peptides de l'isoforme 65 kD de décarboxylase d'acide glutamique chez l'homme, à utiliser dans le traitement et la prévention du diabète. Les analogues de peptides contiennent généralement de une à trois modifications d'acide aminé. Les peptides et analogues peuvent être utilisés dans le diagnostic du diabète et la détection d'une propension au diabète.
Patent CA-2227103-A1 (CA)
Inventor: CAMPBELL SCOTT DOUGLAS
IPC: G16H20/70
Filed: 1998-01-16
Abstract: Wellness plan administration software provides a user interface to enable users to learn about and select a wellness plan. The software tracks wellness plan service items for patients and dynamically estimates discounts forservice items offered to patients during visits to a medical facility. When a patient's visit is complete, the software can generate an invoice automatically and analyze the product and service items provided during the visit to determine theappropriate discount. The software includes additional features for recording promotional activities associated with wellness plans and computing employee bonuses.
Patent CA-2227989-A1 (CA)
Title: Liposomal oligonucleotide compositions
Inventor: NICKLIN PAUL LESLIE
IPC: C12N15/09
Filed: 1996-07-24
Abstract: A pharmaceutical composition comprising (A) an oligonucleotide 8 to 50 nucleotides in length, which is targeted to mRNA encoding human raf and is capable of inhibiting raf expression, entrapped in (B) sterically stabilised liposomes.
Patent CA-2228311-A1 (CA)
Inventor: GEISSBUHLER MICHAEL
IPC: E04B1/82
Filed: 1996-06-22
Abstract: The invention relates to a sound-damping partition, especially for the internal equipment of buildings. The partition consists essentially of a timber sub-frame (10) and two sets of planking (18, 20) on either wide side (12, 14) of the sub-frame (10) leaving a hollow space (16) filled with air and damping materials (36). To obtain improved airborne sound damping using simple means, the invention proposes that one of the sets of planking (20) be secured to the sub-frame (10) by means of thick-walled, soft elastic beads of adhesive (32) while the other set of planking (18) is rigidly clamped to said sub-frame (10).
Patent CA-2231535-A1 (CA)
Title: Imidazole derivatives having affinity for alpha2 receptors activity
Inventor: KARJALAINEN ARTO
IPC: C07D233/56
Filed: 1996-10-02
Abstract: Imidazole derivatives of formula (I), wherein n is 0 or 1, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen or R2 and R3 together form a double bond, R3 is hydrogen or C1-C4-alkyl or R2 and R3 together form a double bond, R4 is hydrogen, C1-C4-alkyl, hydroxy or C1-C4-alkoxy, R5 is hydrogen or C1-C4-alkyl or R4 and R5 together with the carbon atom to which they are attached form a carbonyl group, R6, R7 and R8 are each the same or different and are independently hydrogen, C1-C4-alkyl or C2-C4-alkenyl, C3-C7-cycloalkyl, hydroxy, C1-C4-alkoxy, C1-C4-hydroxyalkyl, thiol, C1-4-alkylthio, Ct_a-alkylthiol, halogen, trifluoromethyl, nitro or optionally substituted amino, X is -CHR9-(CHR10)m-, m is 0 or 1, and R9 and R10 are each the same or different and are independently hydrogen or C1-C4-alkyl; or a pharmaceutically acceptable ester or salt thereof, their preparation, use and pharmaceutical compositions comprising them are described. The compounds have affinity for alpha2 receptors and are useful e.g. in the treatment of hypertension, glaucoma, chronic or acute pain, migraine, diarrhea, common cold, ischemia, addiction to chemical substances, anxiety, especially preoperative anxiety and different neurological, musculoskeletal, psychiatric and cognition disorders or as adjuncts to anesthesia.
Patent CA-2232278-A1 (CA)
Inventor: SCHWIMMER ROBERT
IPC: B62D7/00
Filed: 1998-03-18
Abstract: A spindle grease cap for use with a truck axle is a plug having a top surface, a bottom surface, and a central portion between the top surface and the bottom surface.  There is a threaded opening extending from the top surface through the central portion and to the bottom surface.  A threaded fastener insert fits within the threaded opening for mating engagement therewith in order to close this opening.  An O-ring is located around the central portion.  A threaded retractor is for withdrawing the spindle grease cap from the truck axle.
Patent CA-2234247-A1 (CA)
Inventor: SHINOHARA HISASHI
IPC: A61K31/4704
Filed: 1996-10-01
Abstract: The present invention provides an agent for curing ophthalmological diseases which contains, as the active ingredient, a carbostyril derivative or salt thereof represented by general formula (I), wherein R is a halogen atom, particularly the invention provides effective agent for curing xerophalmia (dry eye) syndrome.
Patent CA-2236755-A1 (CA)
Inventor: CURIAL TODD B
IPC: G01N1/10
Filed: 1998-05-05
Abstract: An apparatus is provided for sampling a liquid flow stream during a dump cycle from a vessel in communication with an oil well production stream in which a sampler receives a continuous sample stream of from the liquid flow stream during the entire duration of the dump cycle to provide a representative sample of the flow stream.
Patent CA-2237311-A1 (CA)
Inventor: BODICK NEIL CLAYTON
IPC: A61K31/55
Filed: 1996-11-08
Abstract: Cette invention porte sur une méthode de traitement de l'anxiété faisant intervenir des composés à base de pyrazine azacyclique et azabicyclique.
Patent CA-2238522-A1 (CA)
Inventor: KUEPPER ANTON
IPC: A61L2/26
Filed: 1996-11-20
Abstract: A test pack, for use in testing the efficiency of a sterilization cycle in a sterilizer, includes a challenge medium (7) in the form of a particulate or sintered material. The challenge medium is contained in an enclosure (4), which is generally-conical in shape. The enclosure (4) has an opening (6) at the wide end for the entry of sterilant and a sterilant sensor (8) at the other end.