Patent SG-11201804191T-A (SG)
Title: System and method for mapping functional nerves innervating wall of arteries,3-d mapping and catheters for same
Inventor: WANG JIE
IPC: A61N1/00
Filed: 2016-12-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau imi d e j. , 00 ) (43) International Publication Date ..., ....r .,„01 8 June 2017 (08.06.2017) W I P0 1 PCT (10) WO International 411141311114114110011111NEHEIIEHIMMEMIE 2017/093926 Publication Number Al (51) International Patent Classification: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, A61B 18/14 (2006.01) A61N 1/00 (2006.01) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (21) International Application Number: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, PCT/IB2016/057258 ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 1 December 2016 (01.12.2016) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (26) Publication Language: English TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (30) Priority Data: DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 14/956,350 1 December 2015 (01.12.2015) US LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant: SYMAP MEDICAL (SUZHOU), LTD GW, KM, ML, MR, NE, SN, TD, TG). [CN/CN]; Unit 601, Building B3, 218 Xinghu Street, Su- zhou Industrial Park, Suzhou, Jiangsu 215123 (CN). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(0) (72) Inventor: WANG, Tie; 329 Casper Road, Englewood Cliffs, NJ 07632 (US). — as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, — as to the applicant's entitlement to claim the priority of the AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, earlier application (Rule 4.17(iii)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Published: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, — with international search report (Art 21(3)) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) Title: SYSTEM AND METHOD FOR MAPPING FUNCTIONAL NERVES INNERVATING WALL OF ARTERIES,3-D MAPPING AND CATHETERS FOR SAME Figure 25 2520 .72510 1. 11 .4t ei cr\ M cr\ o (57) : Disclosed herein are system and method for locating and identifying nerves innervating the wall of arteries such as ---- the renal artery. The system identifies area on vessel wall innervated with nerves; provides indication on whether energy is delivered L 3 / 4 - accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The ::::; method includes evaluating a change in physiological parameters after energy is delivered to arterial wall; and determining the type N of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system in - 0 dudes at least a device (101) for delivering energy to the wall of blood vessel; sensor (103) for detecting physiological signals from a subject; and indicator (105) to display results obtained using said method. Also provided are catheters (2510, 2520) for performing the mapping and ablating functions.