baber/WOPTO huggingface dataset:
Patent BR-112023002420-A2 (BR)
Title: Embalagem dispensadora e método para liberação controlada de uma composição viscosa
Inventor: BILLY GONZALES ABERGAS
IPC: A45D40/26
Filed: 2021-08-09
Abstract: EMBALAGEM DISPENSADORA E MÉTODO PARA LIBERAÇÃO CONTROLADA DE UMA COMPOSIÇÃO VISCOSA. Trata-se de embalagem dispensadora para liberação controlada de uma composição viscosa em uma superfície-alvo. A embalagem dispensadora inclui um aplicador dispensador com uma câmara interna contendo uma composição viscosa e um cabeçote dispensador disposto em torno de pelo menos uma porção do recipiente para definir uma extremidade externa do recipiente. O cabeçote dispensador tem uma superfície frontal com um centroide da superfície frontal e uma superfície traseira oposta com um centroide da superfície traseira e uma pluralidade de orifícios de dispensação que se estendem através do mesmo. Cada um dentre a pluralidade de orifícios de dispensação inclui uma extremidade frontal aberta com um centroide frontal na superfície frontal, uma extremidade traseira aberta com um centroide traseiro na superfície traseira e um eixo geométrico de orifício de dispensação que se estende através dos centroides frontal e traseiro. Um eixo geométrico central se estende através do centroide da superfície frontal e do centroide da superfície traseira e um plano que se estende ao longo do eixo geométrico central. Um primeiro orifício de dispensação dentre a pluralidade de orifícios de dispensação tem um primeiro eixo geométrico de orifício de dispensação inclinado em um primeiro ângulo agudo de orifício a1 (graus) em relação ao plano, de modo a cruzar o plano em um primeiro ponto acima da superfície frontal.
Patent BR-112023005426-A2 (BR)
Title: Métodos para aumentar a expressão do polipeptídeo heterólogo, para produzir um polipeptídeo heterólogo e para produzir uma célula de mamífero recombinante
Inventor: SIMON AUSLAENDER
IPC: C12N15/90
Filed: 2021-09-23
Abstract: MÉTODOS PARA AUMENTAR A EXPRESSÃO DO POLIPEPTÍDEO HETERÓLOGO, PARA PRODUZIR UM POLIPEPTÍDEO HETERÓLOGO E PARA PRODUZIR UMA CÉLULA DE MAMÍFERO RECOMBINANTE. Neste documento é relatado um método para gerar uma célula de mamífero recombinante que expressa um polipeptídeo heterólogo e um método para produzir um polipeptídeo heterólogo usando a referida célula de mamífero recombinante, em que na célula recombinante a expressão do pelo menos o gene endógeno MYC foi reduzida. Verificou-se que o nocaute de pelo menos o gene endógeno MYC em células de mamíferos, por exemplo células CHO, melhora a produtividade recombinante pelas células.
Patent BR-112023005555-A2 (BR)
Title: Determinação da capacidade do equipamento do usuário para medir um sinal de referência de posicionamento de ligação descendente através de uma pluralidade de saltos de frequência
Inventor: ALEXANDROS MANOLAKOS
IPC: H04W72/00
Filed: 2021-08-18
Abstract: DETERMINAÇÃO DA CAPACIDADE DO EQUIPAMENTO DO USUÁRIO PARA MEDIR UM SINAL DE REFERÊNCIA DE POSICIONAMENTO DE LIGAÇÃO DESCENDENTE ATRAVÉS DE UMA PLURALIDADE DE SALTOS DE FREQUÊNCIA. A presente invenção refere-se, em um aspecto, a um componente de rede (por exemplo, BS, LMF, etc.) que determina uma capacidade do UE realizar salto de frequência de recepção para medir um sinal de referência de posicionamento de ligação descendente (DL-PRS) através de uma pluralidade de saltos de frequência, o DL-PRS transmitido através de uma pluralidade de símbolos multiplexados por divisão de frequência ortogonal (OFDM) em uma mesma largura de banda de transmissão (por exemplo, sem salto de frequência), e cada um da pluralidade de saltos de frequência associados a uma sub-banda da largura de banda de transmissão do DL-PRS, e configura um ou mais parâmetros associados ao posicionamento do UE com base, pelo menos em parte, na capacidade. Em alguns designs, o UE pode enviar uma indicação da capacidade ao componente de rede para facilitar a determinação, enquanto em outros designs o componente de rede pode determinar a capacidade por meio de outro mecanismo.
Patent BR-112023015584-A2 (BR)
Title: Antagonistas de gpr84 e usos dos mesmos
Inventor: LARIVÉE ALEXANDRE
IPC: C07D213/89
Filed: 2022-02-02
Abstract: antagonistas de gpr84 e usos dos mesmos. a presente invenção fornece compostos da fórmula i, composições dos mesmos e métodos de uso dos mesmos para a inibição de gpr84 e o tratamento de distúrbios mediados por gpr84.
Patent BR-112023016121-A2 (BR)
Title: Anticorpo triespecífico que direciona bcma, gprc5d e cd3
Inventor: DANLIN DAN QING YANG
IPC: C07K16/28
Filed: 2022-02-15
Abstract: anticorpo triespecífico que direciona bcma, gprc5d e cd3. são aqui fornecidos anticorpos multiespecíficos que se ligam especificamente a bcma, gprc5d e cd3 e fragmentos de ligação ao antígeno multiespecíficos dos mesmos. também são descritos polinucleotídeos relacionados capazes de codificar os anticorpos multiespecíficos ou fragmentos de ligação ao antígeno multiespecíficos fornecidos, células que expressam os anticorpos multiespecíficos ou fragmentos de ligação ao antígeno multiespecíficos fornecidos, assim como vetores associados e anticorpos multiespecíficos ou fragmentos de ligação ao antígeno multiespecíficos detectavelmente marcados. além disso, são descritos métodos de produção e uso dos anticorpos multiespecíficos e fragmentos de ligação ao antígeno fornecidos. são também aqui fornecidos anticorpos que se ligam ao bcma e fragmentos de ligação ao antígeno dos mesmos. são também descritos polinucleotídeos relacionados capazes de codificarem os anticorpos ou fragmentos de ligação ao antígeno específicos para bcma fornecidos, células expressando os anticorpos ou fragmentos de ligação ao antígeno fornecidos, bem como vetores associados e anticorpos específicos para bcma ou fragmentos de ligação ao antígeno detectavelmente marcados. além disso, são descritos métodos de produção e uso dos anticorpos específicos para bcma e fragmentos de ligação ao antígeno fornecidos.
Patent CZ-20141-A3 (CZ)
Inventor: KARAS FILIP
IPC: C04B35/505
Filed: 2014-01-02
Abstract: ﻿Vynález se týká přípravy a výroby membrán pro vysokoteplotní elektrolýzu vody. V tomto procesu slouží jako separátor a pevný elektrolyt keramická membrána, která je tvořena polykrystalem zirkonia, jenž je stabilizovaná yttriem v kubické struktuře. Tyto membrány jsou v průběhu výroby vystaveny teplotám nad 1000 .degree.C, kdy jedním z důležitých parametrů jsou jejich povrchové vlastnosti z důvodu dosažení optimálního třífázového kontaktu. Povrchové vlastnosti membrány se podařilo vylepšit aplikací modifikující suspenze tvořené směsí obsahující 0,13 % hmotn. oxidu zirkoničitého 0,02 % hmotn. oxidu yttritého a 99,85 % hmotn. ethanolu, kdy po odpaření ethanolu při teplotě 20 .degree.C a tlaku par ethanolu 5000 až 5200 Pa, dojde k výpalu membrány. Teplota výpalu nesmí být příliš nízká, aby došlo ke spojení materiálu membrány s modifikující suspenzí a zároveň příliš vysoká, aby nedošlo k opětovné tvorbě povrchu skelného charakteru. Z tohoto důvodu je teplota výpalu zpravidla 1200 až 1400 .degree.C. Podobný vliv na kvalitu nově vytvořeného třífázového kontaktu má i doba, po kterou dochází k výpalu, jenž se pohybuje od 1 do 5 hodin.
Patent CZ-37396-A3 (CZ)
Title: Substituted dihydropyranopyridines per se and for the use in medicine, process and intermediates for their preparation, pharmaceutical compositions based thereon and process of their preparation
Inventor: VAN LOMMEN GUY ROSALIA EUGENE
IPC: A61K31/35
Filed: 1994-08-12
Abstract: PCT No. PCT/EP94/02700 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05381 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds of formula    <IMAGE>  (I)  the pharmaceutically acceptable acid addition salts thereof, the +E,uns N+EE -oxides thereof and the stereochemically isomeric forms thereof, wherein =a1-a2=a3-a4= is a bivalent radical of formula:=N-CH=CH-CH=(a),=CH-N=CH-CH=(b),=CH-CH=N-CH=(c),=CH-CH=CH-N=(d),wherein in said bivalent radicals one or two hydrogen atoms can be substituted by halo, hydroxy, C1-6alkyl or C1-6alkyloxy; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; Alk1 is C1-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a five- or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula    <IMAGE>  (aa)  wherein R4 is hydrogen, cyano, aminocarbonyl or C1-6alkyl; R5 is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl; R6 is hydrogen or C1-6alkyl; or R5 and R6 taken together may form a bivalent radical of formula -(CH2)4- or -(CH2)5-. Pharmaceutical compositions, preparations and use as a medicine are described.
Patent CZ-60094-A3 (CZ)
Inventor: VONDRACEK FRANTISEK
IPC: F16L47/00
Filed: 1994-03-16
Abstract: Plastové Sroubení pro rozebíratelné spojení plastového
potrubí, případné pro připojení armatury má ve válcovém
tělese (9) Sroubení upraven zálitek (2), jehož krček (1) má
menší vnitřní průměr (5) než je vnitřní průměr (6) zálitku
(2). Na krčku (1) je vytvořena vnější kruhová přítlačná plocha
(4).
Patent CZ-82197-A3 (CZ)
Title: Inhibitors of 5 alpha reductase
Inventor: AUDIA JAMES EDMUND
IPC: A61P15/00
Filed: 1995-09-14
Abstract: A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5 alpha -reductase. The compounds have the formula <CHEM>  wherein  R and R<1> both represent hydrogen or combine to form a bond;     R<2> represents hydrogen or C1-C3 alkyl;     R<3> represents methyl or ethyl;     R<4> and -X-R<5> each occupies one of the 7-, 8-and 9-positions;     R<4> represents hydrogen, halo, methyl or ethyl; X represents C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, a bond, -SO-, -SO2-, -CO-Y-(CH2)n-, -Y-CO-(CH2)n, -CO-, -Z-(CH2)n-, or -SO3-; wherein X groups which are not symmetrical may be in either orientation;     Y represents -S-, -O-, or -NH-;     Z represents -O- or -S-;     n represents 0-3; R<5> represents phenyl, naphthalenyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, anthracenyl, acenaphthalenyl, thiazolyl, benzimidazolyl, indazolyl, thiophenyl, phenanthrenyl, quinolinyl, fluorenyl, isoquinolinyl, indanyl, benzopyranyl, indolyl, benzisoquinolinyl, benzindolyl, benzothiazolyl, benzothiophenyl, quinoxalinyl, benzoxazolyl, tetrazolyl, naphthothiazolyl, quinazolinyl, thiazolopyridinyl, pyridazinoquinazolinyl, benzisothiazolyl, benzodioxolyl, benzodioxinyl, diphenylmethyl or triphenylmethyl; the above R<5> groups are unsubstituted or substituted with 1-3 groups chosen from the group consisting of halo, trifluoromethyl, trifluoroethoxy, C1-C4 alkyl, trifluoromethoxy, hydroxy, C1-C3 alkoxy, nitro, C1-C3 alkylthio, C1-C6 alkanoyl, phenyl, oxo, phenoxy, phenylthio, C1-C3 alkylsulfinyl, C1-C3 alkylsulfonyl, cyano, amino, C1-C3 alkylamino, diphenylmethylamino, triphenylmethylamino, benzyloxy, benzylthio, (mono-halo, nitro or CF3)benzyl(oxy or thio), di(C1-C3 alkyl, C3-C6 cycloalkyl, or C4-C8 cycloalkylalkyl)amino, (mono-C1-C3 alkyl, C1-C3 alkoxy or halo)-(phenyl, phenoxy, phenylthio, phenylsulfonyl or phenoxysulfonyl), C2-C6 alkanoylamino, benzoylamino, diphenylmethylamino(C1-C3 alkyl), aminocarbonyl, C1-C3 alkylaminocarbonyl, di(C1-C3 alkyl)aminocarbonyl, halo-C1-C6 alkanoyl, aminosulfonyl, C1-C3 alkylaminosulfonyl, di(C1-C3 alkyl)aminosulfonyl, phenyl(oxy or thio)(C1-C3 alkyl), (halo, C1-C3 alkyl or C1-C3 alkoxy)phenyl(oxy or thio) (C1-C3 alkyl), benzoyl, or (amino, C1-C3 alkylamino or di(C1-C3 alkyl)amino)(C1-C3 alkyl); or an above R<5> group is substituted with a morpholino(C1-C3 alkyl) group, a phenyl(C1-C3 alkyl)piperidinyl group, a phenyl(C1-C3 alkyl)-Piperidinylaminocarbonyl group, a C2-C6 alkanoylaminothiophenyl group, or a (amino, C1-C3 alkylamino or di(C1-C3 alkyl)amino)naphthalenylsulfonylamino group;     or R<5> is a perhalophenyl group; or a pharmaceutically acceptable salt thereof.
Patent SK-21499-A3 (SK)
Title: Arylsulfonylamino hydroxamic acid derivatives
Inventor: BLUMENKOPF TODD A
IPC: A61P1/04
Filed: 1997-07-25
Abstract: A compound of formula (I) wherein n, X, R<3>, R<4> and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
Patent SK-33396-A3 (SK)
Title: Fusion protein with specific bond to human interleukin-4 and pharmaceutical composition containing its
Inventor: HOLMES STEPHEN D
IPC: C12P21/08
Filed: 1994-09-07
Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
Patent SK-53598-A3 (SK)
Title: Radar altimeter with frequency modulation "i" for low hights
Inventor: LABUN JAN
IPC: G01S13/34
Filed: 1998-04-24
Abstract: The invention relates to the broadband radar altimeter of low altitudes that works with the frequency modulation with measuring the period of the differential signal. The circuitry has behind the balanced mixer connected the shaping circuit for rectangular shaping of the differential signal and the selection of the suitable periods of the differential signal out of the rotation areas of the phase in 180°, behind which there is a decoding circuit for measuring the period of the differential signal and its transformation to the voltage directly proportional to the altitude is connected. The device of shaping and decoding circuit of the period of differential frequency causes total removing of the classic methodic error of the radar altimeter.
Patent SK-75298-A3 (SK)
Inventor: SISKA JOZEF
IPC: F03B17/06
Filed: 1998-06-05
Abstract: Na otáčavej vertikálnej osi (11) vsadenej v ložiskách
(21) prichytených v pevnom ráme (31) sú pohyblivo
prichytené hnacie lopatky (41) pomocou ložísk (51) na
nosných osiach (61) takým spôsobom, aby zarážacie
prvky (71) pripevnené k osi (11) umožňovali hnacím
lopatkám (41) vychýlenie iba v jednom výkyvnom
smere. Na zamedzenie prípadného preklopenia hnacích
lopatiek (41) slúžia pevné zábrany (81).
Patent SK-92995-A3 (SK)
Title: 4-phenoxycoumarins, method of their preparation and their use as herbicidal agents
Inventor: ALVARADO SERGIO I
IPC: A01N47/22
Filed: 1995-07-21
Abstract: Compounds of formula I <CHEM>  wherein   X and X'   are each independently halogen, C1-C4alkyl, or C2-C4alkenyl; W, Y and Z   are each independently O or S; and R and R1   are as defined in Claim 1, methods for their preparation, herbicidal compositions containing them, and methods for the control of monocotyledenous plants, in particular of monocotyledenous weeds in the presence of cereal crops, by applying them.
Patent CH-648180G-A3 (CH)
IPC: H03K3/354
Filed: 1981-07-15
Abstract: A very low current Pierce oscillator has two pairs of complementary field-effect transistors (FET's) and a two-terminal quartz crystal. The gates of the first complementary FET pair are coupled through individual capacitors to one terminal of the quartz crystal, their drains being connected together and to the other quartz crystal terminal. Current flow through the crystal oscillator is minimized by a novel oscillator bias loop connected between the gates of the first FET pair. Amplification is provided by the second FET pair which have a commonly connected drain comprising the oscillator output node. The gates of the second FET pair are each connected to a respective one of the gates of the first FET pair. The oscillator bias loop minimizes the source-to-drain current through the first FET pair by reducing the P-channel FET gate voltage in response to the source-to-drain current. The oscillator bias loop assures reliable start-up by permitting the oscillation of the source-to-drain current to increase freely to some large magnitude and then operates to reduce the amplitude of the oscillation and also the dc bias level of the current to an equilibrium condition. Means are provided for preventing elements within the oscillator bias loop from overloading the oscillator or otherwise preventing the initiation of oscillation at start-up.
Patent CZ-326992-A3 (CZ)
Title: Biosynthetic process for preparing chemical substances
Inventor: ENTIAN KARL-DIETER
IPC: C12R1/625
Filed: 1992-10-30
Abstract: Novel recombinant DNA molecule (I) has a sequence corresp. to one or more DNA sequences contd. in a Bgl II fragment of the 54 Rpb episomal element pTii32 from staphylococcus epidermis and codes for at least one protein having EpiB, EpiC, EpiD, EpiP or EpiQ enzymatic activity; or (I) is capable of hybridising to the BglII fragment and codes for at least one protein with the above enzymatic activities. Also claimed are: the protein EpiB, EpiC, EpiD, EpiP or EpiQ in the absence of impurities with which it is normally associated; a fusion protein compising one of EpiB, C, D, P or Q and an auxiliary protein, a fusion protein in which one of the Epi B, C, D, P or Q is fused to an auxiliary protein such that the junction between the Epi protein and the auxiliary protein can be cleaved by an enzyme; and a method of producing a protein with at least one of the structural features of a lantibiotic. In the novel method comprising inserting a DNA sequence coding for a predetermined aminoacid sequence in a vector plasmid such that it is under the control of a regulator promoter, transforming the resulting plasmid vector into a host and cultivating the host so as to express the DNA and isolating the protein, the improvement comprises also transforming the host by a DNA sequence or sequences comprising functionally operable genes coding for EpiB, C, D, P or Q (or an active variant), the genes being expressed during cultivation of the host so that the resulting protein has at least one of the structural features of a lantibiotic.
Patent CZ-355991-A3 (CZ)
Inventor: SKVARIL PETR ING
IPC: B65H54/06
Filed: 1991-11-25
Abstract: Zařízení pro navíjení cívek, zejména na textilních strojích, obsahující odklopný držák navíjené cívky a jí přiřazený otáčející se odvalovací drážkový rozváděči válec (1), spojený s vnějším pohonem a uspořádaný otočně na pevném hřídeli (4), má drážkový rozváděči válec (1) na pevném hřídeli (4) uložený vratně axiálně posuvně
Patent CZ-371992-A3 (CZ)
Title: Aqueous filling composition
Inventor: EXNER REINER
IPC: C08G63/68
Filed: 1992-12-17
Abstract: An aqueous filler composition containing a polyester resin which is built up from the starting materials (a), (b), (c), (d) and (e) or ester-forming derivatives thereof, where the sum of the reactants corresponds to 100 mol% and the ratio between the sum of the hydroxyl equivalents (eq of OH) and the sum of the carboxyl equivalents in the reactants is between 0.5 and 2.0, where   (a) is at least one dicarboxylic acid which is not a sulpho or phosphorus monomer, (b) from 0 to 15 mol% of at least one difunctional sulpho or phosphono monomer whose functional groups are carboxyl or hydroxyl groups, containing at least one sulphonate or phosphonate group, (c) at least one difunctional compound which is derived from a glycol containing two -C(R)2-OH groups, (d) up to 40 mol% of a higher-functional compound (functionality > 2) whose functional groups comprise hydroxyl and/or carboxyl groups, and   (e) from 0 to 20 mol% of a monofunctional carboxylic acid, where the radicals R in (c) may be, independently of one another, hydrogen, C1-C4-alkyl or C6-C10-aryl, the amounts of free hydroxyl groups are between 30 and 350 milliequivalents of OH/100 g, preferably between 100 and 250 meq of OH/100 g, and the content of free neutralised and/or neutralisable acid groups, in particular sulphonic, phosphonic or carboxyl groups, is between 5 and 350 meq of acid groups/100 g, preferably between 9 and 120 meq of acid groups/100 g.
Patent CZ-403792-A3 (CZ)
Title: Cleansing agent and process for producing thereof
Inventor: DZURNAK MARCEL
IPC: C11D1/10
Filed: 1992-12-31
Abstract: A cleaning agent contains from 6 to 8 percent by weight of diethyleneglycol, 9 to 11 percent by weight of tenside, 3 to 5 percent of triethanol-amine and/or diethanoleamine, 27 to 33 percent by weight of ethylenediaminetetraacetic acid salt, 0.3 to 0.5 percent by weight of formaldehyde, 1 to 2 percent by weight of spirit, 1.5 to 2.5 % by weight of fragrance, and water. One portion of water, which is heated to 30 - 40 degrees Celsius, is added with ethylenediaminetetraacetic acid salt and thus obtained mixture is cooled down to 12 - 18 degrees Celsius, preferably to 15 degrees Celsius, whilst diethyleneglycol, tenside, diethanolamine and/or triethanolamine are gradually added thereto. Formaldehyde is added to the second part of water. The fragrance is added to an aqueous mixture of spirit. Thus prepared mixture is subjected at 10 - 20 degrees Celsius to ultrasound with 9 - 11 Hz frequency during 30 - 60 min and consequently the mixture is exposed to the light with 500 - 100,000 lux intensity.
Patent CZ-109997-A3 (CZ)
Title: Polyesterpolyol, polyurethane foam obtained from such polyesterpolyol as well as use thereof
Inventor: GHESQUIERE DENIS
IPC: C08L67/00
Filed: 1997-04-10
Abstract: Polyol polyester is obtained by reaction between acid (A), containing at least one aliphatic or aromatic polyacid, with hydroxy composition (P2), containing at least one di-functional polyol, and second hydroxy composition (P3) containing at least one polyol with functionality ≥ 3. (P2) consists of monoethyleneglycol and (P3) contains at least 3 oxyalkylene groups with 2-4C alkylene oxide. Also claimed is a polyurethane foam, for use in car interiors, obtained by reaction of polyol polyester with polyisocyanate.
Patent CZ-122697-A3 (CZ)
Title: Preparations and methods of treating disseminated sclerosis
Inventor: SMILEK DAWN
IPC: C12N/
Filed: 1995-10-25
Abstract: The present invention provides isolated peptides and combinations of peptides derived form myelin autoantigens such as MBP, MOG, PLP, and MAG suitable for treating multiple sclerosis, including prophylactic and therapeutic compositions and methods for preventing or treating multiple sclerosis. Preferred compositions of the invention comprise at least one isolated, purified peptide, free from all other polypeptides or contaminants, the peptide comprising an amino acid sequence, the myelin autoantigen which has T cell activity. A therapeutic composition of the invention is capable of down regulating the autoantigen specific immune response to the myelin autoantigen in a population of humans suffering from, or susceptible to multiple sclerosis, such that disease symptoms are reduced, eliminated, or reversed and/or the onset or progression of disease symptoms is prevented or slowed. Additionally, compositions and methods of the instant invention when administered in an advanced stage of disease, reverse ongoing paralysis or other signs of disease when administered during the acute phase of disease or prevents relapse when administered during remission.
Patent CZ-134493-A3 (CZ)
Title: Apparatus for recovery of fuel vapors within a re-filling station
Inventor: BERGAMINI GIORGIO
IPC: B67D7/04
Filed: 1993-07-02
Abstract: A system for vapour recovery in fuel filling installations without the use of seal members between the delivery gun (11) and the filler pipe (3) of the vehicle to be refuelled, comprising control means (15) which in response to electrical signals indicative of the volumetric fuel delivery rate render the volumetric draw-in rate of said recovery means always greater than said volumetric fuel delivery rate; a preferred embodiment of said control means is also described.