Patent SG-11201906519R-A (SG)
Title: Neisseria meningitidis compositions and methods thereof
Inventor: JANSEN KATHRIN UTE
IPC: A61K39/095
Filed: 2018-01-30
Abstract: FIGSubfamily B Protein Subfamily A Protein 45 40 35 30 `6 25 20 15 10 7.5 10 12.5 5 17.5 20 W O 20 18/ 142280 A2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT omit VIII °nolo VIII Ill Oil OH mo lio iflo ois (10) International Publication Number WO 2018/142280 A2 (51) International Patent Classification: CO7K 14/22 (2006.01) (21) International Application Number: PCT/IB2018/050563 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,963 31 January 2017 (31.01.2017) US 62/503,295 08 May 2017 (08.05.2017) US 62/613,945 05 January 2018 (05.01.2018) US 62/623,233 29 January 2018 (29.01.2018) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). (72) Inventors: JANSEN, Kathrin Ute; 160 East 65th Street, New York, NY 10065 (US). ANDERSON, Annaliesa Sy- bil; 49 Hillcrest Drive, Upper Saddle River, NJ 07458 (US). ABSALON, Judith; 55 West 116th Street, New York, NY 10026 (US). BEESLAAR, Johannes Frederik; Pfiz- er Limited, Ramsgate Road, Sandwich Kent CT13 9NJ (GB). FARLEY, John Erwin; 101 Michaels Way, Chapel Hill, NC 27516 (US). FLETCHER, Leah Diane; 37 Se- cond Street, Geneseo, NY 14454 (US). HARRIS, Shan- non Lea; 142 West Prospect Street, Nanuet, NY 10954 (US). JONES, Thomas Richard; 4 Fieldcrest Drive, New City, NY 10956 (US). KHANDKE, Lakshmi; 120 East Allison Avenue, Nanuet, NY 10954 (US). LIBERATOR, Paul; 37 Hillcrest Road, Holmdel, NJ 07733 (US). PEREZ, John Lance; 59-33 Corrigan Road, Doylestown, PA 18902 (US). PHELAN, Lynn Marie; 15 Sheffield Street, Lake Hiawatha, NJ 07034 (US). ZLOTNICK, Gary Warren; 915 Steubing Oaks, San Antonio, TX 78258 (US). COOP- ER, David; 9 Webb Farm Road, Monroe, NY 10950 (US). ASTE-AMEZAGA, Jose Miguel; 293 Stormfield Drive, Harleysville, PA 19438 (US). KANEVSKY, Isis; 157 West 79th Street, New York, NY 10024 (US). (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). (54) Title: NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF min MnB rLP2086 without MenACVVY-TT MnB rLP2086 MenACWY-TT (57) : In one aspect, the invention relates to a composition including a factor H binding protein (ffIBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants. [Continued on next page] WO 2018/142280 A2 lilillEHEIMIREIHOMMIEHEE0110ThiMill (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) with sequence listing part of description (Rule 5.2(a))