baber/WOPTO huggingface dataset:
Patent AU-2020229436-A1 (AU)
Title: Novel fusion proteins specific for CD137 and GPC3
Inventor: BEL AIBA RACHIDA SIHAM
IPC: A61K38/00
Filed: 2020-02-25
Abstract: The disclosure provides fusion proteins specific for both CD137 and GPC3, which fusion protein can be used to co-stimulate lymphocyte activation in a GPC3-target-dependent manner. Such fusion proteins can be used in many pharmaceutical applications, for example, as anti-cancer agents and/or immune modulators for the treatment or prevention of human diseases such as a variety of tumors. The present disclosure also concerns methods of making the fusion proteins described herein as well as compositions comprising such fusion proteins. The present disclosure further relates to nucleic acid molecules encoding such fusion proteins and to methods for generation of such fusion proteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of such fusion proteins as well as compositions comprising one or more of such fusion proteins.
Patent AU-2020257086-A1 (AU)
Title: External ear canal pressure regulation device
Inventor: GEORGE DAVID
IPC: A61F11/00
Filed: 2020-10-21
Abstract: An external ear canal pressure regulation device including a fluid flow generator, an 
earpiece having an axial earpiece bore, and a valved conduit fluidicly coupled to the fluid flow 
generator and the axial earpiece bore, whereby the earpiece has a compliant earpiece external 
5 surface configured to sealably engage an external ear canal as a barrier between an external ear 
canal pressure and an ambient pressure.
Patent AU-2020266302-A1 (AU)
Title: Online payment system
Inventor: BALDWIN THOMAS
IPC: G06Q20/12
Filed: 2020-04-30
Abstract: A system and method for facilitating an online transaction between a customer and a merchant, wherein receipt of an input from a merchant server defining a specified payment transaction causes a link generation module to generate a URL link uniquely associated with an online data capture resource for the specified transaction, such that activation of said link by a customer device facilitates a data capture process causing payment data to be provided to a payment module for completion of said specified financial transaction via a payment service provider.
Patent AU-2020266874-A1 (AU)
Title: An autonomous, integrated computer-enabled method, system, and computer program utilising an artificial intelligence engine for dynamic allocation and optimisation of space, furniture, equipment and/or services
Inventor: PETROULAS PETER
IPC: G06Q10/04
Filed: 2020-04-28
Abstract: In one aspect, there is provided a computer-enabled method for optimising and allocating bookings to one or more spaces, the method optimising bookings to increase the probability of achieving a selected outcome. In one embodiment, the invention is directed to an online restaurant booking system that utilises an artificial intelligence engine to optimise the use of space, time, and other operational considerations of a restaurant in order to optimise desired outcomes which may include optimising capacity, ambiance, preferred seating allocation, extended booking duration times, variable and dynamic pricing options, menu and course options and other quantitative and qualitative criteria.
Patent AU-2020273347-A1 (AU)
Title: Bispecific antibodies against CD3epsilon and BCMA
Inventor: VU MINH DIEM
IPC: C07K16/28
Filed: 2020-11-20
Abstract: BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND BCMA 
ABSTRACT 
A bispecific bi- or trivalent antibody specifically binding to the two targets which are 
extracellular domain of human B cell maturation antigen (BCMA) and human CD3epsilon, 
wherein the variable domains VL and VH in a light chain and the respective heavy chain are 
replaced by each other, characterized in comprising a constant domain CL wherein the amino 
acid at position 124 is substituted independently by lysine (K), arginine (R) or histidine (H) 
(numbering according to Kabat), and in the respective constant domain CH1 the amino acid at 
position 147 and the mino acid at position 213 is substituted independently by glutamic acid (E), 
or aspartic acid (D) (numbering according to Kabat). Also the manufacture and use of said 
antibody.
Patent AU-2020276500-A1 (AU)
Title: Humanized anti-CD137 antibodies and uses thereof
Inventor: WANG JIEYI
IPC: A61K39/395
Filed: 2020-05-08
Abstract: Disclosed herein are humanized anti-CD 137 antibodies and methods of using such for eliciting CD 137 signaling, thereby enhancing immune responses such as T cell functions. The antibodies disclosed within may be used to treat diseases, such as cancer and immune disorders.
Patent AU-2020281075-A1 (AU)
Title: Mammalian cell culture
Inventor: FOLLSTAD BRIAN D
IPC: C12N5/10
Filed: 2020-12-03
Abstract: The invention provides a method for culturing mammalian cells. The method provides 
greater control over cell growth to achieve high product titer cell cultures.
Patent AU-2020286172-A1 (AU)
Title: Antibacterial biomedical implants and associated materials, apparatus, and methods
Inventor: DAVIS KEVIN
IPC: C04B35/58
Filed: 2020-12-07
Abstract: Methods for improving the antibacterial characteristics of biomedical implants and related 
implants manufactured according to such methods. In some implementations, a biomedical 
implant comprising a silicon nitride ceramic material may be subjected to a surface roughening 
treatment so as to increase a surface roughness of at least a portion of the biomedical implant 
to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some 
implementations, a coating may be applied to a biomedical implant. Such a coating may 
comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, 
the surface roughening treatment process. See Figs. 1A to IC.
WO 2018/182835 PCT/US2018/014781 
1/13 
113 112 100 
FIG. 1A 110 
1020 
108 
113 112 100 
110 
FIG. 1B 1102 
.10 
104 
,< 113 112 100 
110 
FIG. 1C 11102 
114 
0 o o108 
114 
104
Patent AU-2020310626-A1 (AU)
Title: Method and package for evenly roasting seeds in a microwave
Inventor: ALMOG YAACOV
IPC: B65D81/34
Filed: 2020-07-09
Abstract: The present invention provides packages pre-packed with nuts/seeds for roasting thereof in a microwave.
Patent AU-2020311780-A1 (AU)
Title: Vacuum adiabatic body, refrigerator, and method for fabricating the refrigerator
Inventor: BAE JAEHYUN
IPC: F16L59/065
Filed: 2020-07-08
Abstract: Provided is a vacuum adiabatic body. The vacuum adiabatic body includes a thin pipe passing through the main body to connect an inside of the accommodation space to an outside of the accommodation portion, a drain pipe provided inside the thin pipe to discharge the defrosting water, and an adiabatic material having an extension extending along the drain pipe to block heat transfer between the drain pipe and the thin pipe and a head provided at one side of both sides of the extension, which is close to the accommodation space.
Patent AU-2020322415-A1 (AU)
Title: KLF induced cardiomyogenesis
Inventor: KIKUCHI KAZU
IPC: C12N5/071
Filed: 2020-07-30
Abstract: The technology relates to a method for inducing cardiomyogenesis comprising administering a therapeutically effective amount of either or both of KLF1 and KLF2b to increase the level of KLF1 and/or KLF2b in the cardiomyocytes thereby inducing cardiomyogenesis.
Patent AU-2020337958-A1 (AU)
Title: Methods for the treatment of thyroid eye disease
Inventor: SHERMAN JEFFREY
IPC: A61K39/395
Filed: 2020-08-28
Abstract: Provided herein are methods of treating or reducing the severity of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.
Patent AU-2020345560-A1 (AU)
Title: Catheter system to facilitate blood sampling and related methods
Inventor: KUNARDI LINDA
IPC: A61B5/15
Filed: 2020-08-20
Abstract: A catheter system (10) may include a catheter assembly (12), which may include a catheter adapter (14) and a catheter (16) extending distally from a distal end of the catheter adapter. The catheter system may also include a needle assembly (22), which may include a needle hub (24) and an introducer needle (25). The needle hub may include: a distal end coupled to the proximal end of the catheter adapter; a proximal end; a wall disposed between the distal end of the needle hub and the proximal end of the needle hub; and a flashback chamber proximate the wall. The introducer needle may be press-fit within a through-hole of the wall. The catheter system may also include a plug coupled to the proximal end of the needle hub. A blood collection device may be coupled to a proximal end of the plug to collect blood from a patient.
Patent AU-2020360042-A1 (AU)
Title: Pull-out cabinet unit
Inventor: STORCK HOLGER
IPC: A47B88/42
Filed: 2020-09-22
Abstract: The invention relates to a cabinet drawer (1), in particular for tall cabinets, comprising a frame (4) which is to be arranged in the interior of the cabinet body (2) and has a cabinet door (3) or a similar cabinet covering on the front face on a vertical longitudinal support (6). The frame (4), which has a respective support base (7), can be moved out of a first operating position, which lies within the cabinet body (2), into a pull-out position, which lies in front of the cabinet body (2), as a second operating position in a translational manner, and the frame (4), which has an upper (8) and a lower (9) pull-out rail, can be converted into the second operating position using a rear vertical longitudinal support (5) such that the frame (4) can be pivoted about a vertical pivot axis in the second operating position. The cabinet drawer (1) is paired with a blocking device (13) which prevents the frame (4) from carrying out a pivoting movement before reaching the second operating position and releases the frame (4) to carry out a pivoting movement in the second operating position. The aim of the invention is to improve such a cabinet drawer (1). This is achieved in that the blocking device (13) has a slotted gate part (14) which can be pivoted about a vertical axis and comprises a guide path (15), the slotted gate part (14) together with the frame (4) can be moved into the second operating position, a guide part (16) of the frame (4) is guided in the guide path (15) of the slotted gate part (14) during a part of the pivoting movement of the frame, and the slotted gate part (14) is arranged within the blocking device (13) in the course of the translational movement of the frame (4) into the second operating position so as to be prevented from carrying out a pivoting movement.
Patent AU-2020384729-A1 (AU)
Title: NPY2 receptor agonists
Inventor: HAEBEL PETER WILHELM
IPC: A61P3/00
Filed: 2020-11-09
Abstract: The invention relates to PYY analogues having alanine at position 4, lysine at position 7, QRY as the C-terminal end and a half-life extending group. The analogues of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogues, and to the medical use of the analogues.
Patent AU-2020388049-A1 (AU)
Title: Shielding of electronics from magnetic fields
Inventor: KYAW PHYO AUNG
IPC: H01F27/02
Filed: 2020-11-18
Abstract: Some aspects relate to an apparatus, comprising: a coil; an electronic circuit; and an electrically conductive shield positioned between the coil and the electronic circuit. Some aspects relate to an apparatus, comprising: a coil; an electronic circuit; and a magnetic core magnetically coupled to the coil, the magnetic core having an overhang protruding on a side of the magnetic core facing the electronic circuit.
Patent AU-2020397366-A1 (AU)
Title: Method and device for controlling generator-side terminal voltage of converter, and controller of converter
Inventor: WANG JINPENG
IPC: H02P9/14
Filed: 2020-05-26
Abstract: Provided are a method and device for controlling the generator-side terminal voltage of a converter, and a controller of a converter. The method comprises: on the basis of a current voltage value of a DC bus of a converter, determining the upper limit of a target value of the generator-side terminal voltage, the generator-side terminal voltage being the terminal voltage of a generator whose output terminal is connected to the converter; determining a current target value of the generator-side terminal voltage which can minimize the generator-side current, and taking the target value of the generator-side terminal voltage to be an optimal target value of the generator-side terminal voltage, the generator-side current being the output current of the generator; on the basis of the determined upper limit of the target value of the generator-side terminal voltage and the optimal target value of the generator-side terminal voltage, setting the target value of the generator-side terminal voltage.
Patent AU-2020414489-A1 (AU)
Title: Method for purifying biologically active peptide by using protein a affinity chromatography
Inventor: SONG DAEHAE
IPC: C07K16/18
Filed: 2020-12-24
Abstract: The present invention provides a method for purifying an Fc-containing biologically active peptide mixture by using an affinity column comprising an affinity matrix that contains a protein A ligand, the mixture comprising a first Fc-containing biologically active peptide and a second Fc-containing biologically active peptide, wherein the second Fc-containing biologically active peptide comprises at least one more human VH3 domain than the first Fc-containing biologically active peptide. According to the purification method, biologically active peptides having the same or similar structures can be precisely separated with high purity, while process simplification is achieved.
Patent WO-2022047539-A1 (WO)
Title: Nerve stimulation system
Inventor: FRANK PAUL CLINTON
IPC: A61N1/36
Filed: 2021-09-03
Abstract: A nerve stimulation system for stimulating occipital and/or cervical nerves in a biological subject. The system incorporates a lead including a lead body having a first portion positioned proximate a distal end of the lead body, a second portion spaced from the first portion and a connecting portion interconnecting the first and second portions. First electrode(s) carried by the first portion are provided proximate an occipital nerve, with second electrode(s) carried by the second portion being provided proximate a cervical nerve. First signals are applied to the first electrode(s) to modulate the occipital nerve and second signals that are applied to the second electrode(s) to thereby modulate the cervical nerve.
Patent AU-2021202311-A1 (AU)
Title: Systems and methods for improved maintenance of patient-associated problem lists
Inventor: ZASOWSKI JEREMY M
IPC: G16H10/60
Filed: 2021-04-16
Abstract: SYSTEMS AND METHODS FOR IMPROVED MAINTENANCE OF PATIENT
ASSOCIATED PROBLEM LISTS 
ABSTRACT 
This disclosure describes systems, devices, and techniques for managing medical 
documentation associated with a patient. In one example, a computerized system for 
managing medical information associated with a patient may include one or more 
computing devices configured to identify one or more potential medical problems with the 
patient from encounter-related information associated with the patient, generate a list 
comprising the one or more potential medical problems, and output, for display, the list.  
The one or more computing devices may also be configured to receive an indication of 
selection input from a user and associated with at least one of the potential medical 
problems and update the list of potential medical problems according to the indication of 
the selection input.
Patent AU-2021204475-A1 (AU)
Title: Tagged chimeric effector molecules and receptors thereof
Inventor: RIDDELL STANLEY R
IPC: A61K35/17
Filed: 2021-06-29
Abstract: TAGGED CHIMERIC EFFECTOR MOLECULES AND RECEPTORS 
THEREOF 
ABSTRACT 
The application concerns tagged chimeric effector molecules and receptor molecules thereof for 
genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, 
sorted, induced to proliferate, tracked or eliminated using the tag. In particular, the application 
concerns chimeric antigen receptors (eARs) having an extracellular domain comprising a binding 
domain for a target, a hinge region and a tag cassette, a hydrophobic portion as a transmembrane 
domain and, an intracellular part with an effector domain. The preferred target is CD19 and the 
preferred tag is a Step- tag. T cells recombinantly modified for expression of such molecules 
may be used in adoptive immunotherapy.
Patent AU-2021209620-A1 (AU)
Title: Lumen reinforcement and anchoring system
Inventor: BESSLER MARC
IPC: A61F2/20
Filed: 2021-01-20
Abstract: A tissue wall of a biological lumen may be reinforced by embedding a material or structure into the tissue wall. The reinforcement material or structure may embed by application of outwardly directed force along an interior side of the tissue wall, threading, or injection. The reinforcement material or structure may act as an embedded scaffold that limits expansion or contraction of the tissue wall to pushing or pulling forces. An anchor device, such as a medical device, may anchor to the reinforced portion of the tissue wall.
Patent AU-2021216630-A1 (AU)
Title: Testosterone containing pharmaceutical composition
Inventor: WHITAKER MARTIN
IPC: A61K47/44
Filed: 2021-01-18
Abstract: A pharmaceutical composition for adapted for oral administration comprising at least 10 % w/w native testosterone, at least 36% w/w sesame oil, at least 28% w/w propylene glycol monolaurate, at least 9 % w/w ethanol and at least 14 % w/w benzyl alcohol. A dosage regimen for use in a human subject comprising administering at least a first and a second pharmaceutical compositions wherein, the first composition comprises between 2.5-7.5 % w/w native testosterone, sesame oil, propylene glycol monolaurate, ethanol and benzyl alcohol; and the second composition comprises at least 9% w/w native testosterone, sesame oil, propylene glycol monolaurate, ethanol and benzyl alcohol; wherein said first and second compositions are administered orally at least once in a 24- hour period to said human subject to normalise serum testosterone. A process to produce a composition comprising native testosterone comprising i) forming a homogeneous preparation comprising sesame oil, propylene glycol monolaurate, benzyl alcohol and ethanol; ii) adding native testosterone at a concentration of about 13% w/w to said homogeneous preparation to form a combined testosterone preparation; and iii) mixing the combined preparation to dissolve testosterone to form a substantially clear preparation.
Patent AU-2021217210-A1 (AU)
Title: Estimation of crop type and/or sowing date
Inventor: TEWARI MUKUL
IPC: G06Q50/02
Filed: 2021-01-26
Abstract: Method, apparatus, and computer program product are provided for estimating crop type and/or sowing date. A historical crop growth time series and a plurality of simulated crop growth time series are determined, and the historical time series is matched against each simulated time series to determine an estimated crop type and/or sowing date. For example, one simulated time series may be determined for each crop type/sowing date combination within a set of one or more crop types and one or more sowing dates based on historical crop data. Each time series represents crop growth in an area of interest and comprises element(s) including crop-specific parameter(s), such as leaf area index (LAI). The historical time series may be determined based on remote sensor data. Each simulated time series may be determined using a crop growth simulation model and based on historical crop data, geospatial data, and weather data.
Patent AU-2021218005-A1 (AU)
Title: Electrosurgical device and methods
Inventor: GILBERT JAMES A
IPC: A61B18/00
Filed: 2021-08-16
Abstract: A tissue segmentation device, controller, and methods therefore are disclosed. The 
device has an active electrode, a return electrode, a mechanical force application mechanism, 
voltage and current sensors, and a controller. The controller is configured to control a power 
output of the segmentation device. The controller has a processing component, responsive to 
the sensors, configured to execute the following: (a) derive a power factor of power applied 
to the at least one electrode; and (b) responsive to the deriving a power factor, assign a circuit 
status to a circuit comprising the at least one electrode. IF (PF ~ 0) and ((Vrms/Irms);> T), 
THEN the circuit status is "open". IF (PF ~ 0) and ((Vrms/Irms) < T), THEN the circuit 
status is "short". PF is the power factor. T is a threshold value.
Patent AU-2021220916-A1 (AU)
Title: Assembly apparatus for implementing assembly steps on a wall and method for arranging a magazine component on an assembly apparatus
Inventor: CAMBRUZZI ANDREA
IPC: B66B19/00
Filed: 2021-02-01
Abstract: The invention relates to an assembly apparatus for implementing assembly steps on a wall and to a method for arranging a magazine component on a magazine-receiving apparatus of an assembly apparatus. The assembly apparatus has a mobile assembly frame (14), a mechatronic installation component, a magazine-receiving apparatus (10), a magazine component (18a, 18b, 18c) and a securing device (42). The magazine-receiving apparatus (10) is intended to receive the magazine component (18a, 18b, 18c) with assembly means received therein. The securing device (42) is designed, and arranged, in such a manner that, in a securing state, it establishes a connection between the magazine component (18a, 18b, 18c) and the assembly frame (14) and thereby secures the magazine component (18a, 18b, 18c), once received in the magazine-receiving apparatus (10), against displacement in relation to the assembly frame (14). The magazine component (18a, 18b, 18c) has a first coupling element and the securing device (42) has a second coupling element. The first coupling element and the second coupling element are designed, and arranged, in such a manner that, by means of the two coupling elements, the securing device (42) can be coupled in a releasable manner to the magazine component (18a, 18b, 18c).
Patent AU-2021224778-A1 (AU)
Title: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
Inventor: TREMBLAY FREDERIC
IPC: A61K31/713
Filed: 2021-02-12
Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the apolipoprotein C3 gene (APOC3). The invention also relates to methods of using such RNAi agents to inhibit expression of an APOC3 gene and to methods of preventing and treating an APOC3-associated disorder, e.g., hypertriglyceridemia, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, polycystic ovary syndrome, kidney disease, obesity, type 2 diabetes mellitus (insulin resistance), hypertension, artherosclerosis and pancreatitis.
Patent AU-2021227230-A1 (AU)
Title: Use of cyclosporine analogues for treating cancer
Inventor: URE DAREN R
IPC: A61P35/00
Filed: 2021-02-24
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in preventing and treating proliferative diseases such as cancer. The methods comprise administering to a subject in need thereof a composition comprising a cyclosporine analogue (e.g., CRV431), or a pharmaceutically acceptable salt, solvate, stereoisomer thereof. The compositions and kits comprise a cyclosporine analogue (e.g., CRV431), or a pharmaceutically acceptable salt, solvate, stereoisomer thereof.