baber/WOPTO huggingface dataset:
Patent EA-009373-B1 (EA)
Title: 8-chloro-2,3-benzodiazepine derivatives
Inventor: BARKOCZY JOSEF
IPC: C07D243/02
Filed: 2004-07-29
Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I),wherein R stands for a lower alkyl group or a group of the general formula -NH-R', wherein R' stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives.The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
Patent EA-013149-B1 (EA)
Title: Safety cap for a bottle
Inventor: ZAETS VLADIMIR VLADIMIROVICH
IPC: B65D50/00
Filed: 2008-01-24
Abstract: The invention relates to closures for containers with liquids having a means of indicating of opening. A safety cap for a bottle includes a cover fastened by means of the thread on an outer bush, which is connected by edges to an inner bush forming the passes, a metal casing consisting of two parts, one part of which is installed on the cover, and another is installed on the outer bush. A checking indicator collar is made along the perimeter of the lower edge of the cover, the adjacent edges of the parts of the metal casing are folded in the checking indicator collar with the possibility of releasing one of the casing edges when the cover is being turned on. Along the perimeter of the lower edge of the cover from the inner part thereof on the level of the indicator collar an additional collar is made, which thickness exceeds the thickness of the indicator collar, and the indicator collar and the additional collar are made as a whole with the cover forming a gap between the edges of the indicator collar and the additional collar. The width of said gap, after the releasing one of the metal casing edges when the cover is being turned on, exceeds the width of said gap when the cover is initially closed. The invention provides to improve the reliability of the protection of the bottle from the adulteration of the content of the bottle corked up by the safety cap, and also to improve the reliability of the repeated closing in partial use of the liquid in the bottle.
Patent EA-012802-B1 (EA)
Title: Glycosylated il-7, preparation and uses
Inventor: MORRE MICHEL
IPC: C07K14/54
Filed: 2006-07-19
Abstract: The present invention relates to new and improved interleukin-7 polypeptides, as well as compositions comprising the same, their preparation and uses. The invention more particularly relates to hyperglycosylated IL-7 polypeptides having improved properties, as well as their manufacture and therapeutic uses. The invention also discloses novel IL-7 polypeptides having modified amino acid sequences containing artificially created glycosylation site(s), as well as corresponding nucleic acid molecules, vectors and recombinant host cells. The invention also relates to the use of such polypeptides, cells or nucleic acids for curative or preventive treatment of mammalian subjects, including human subjects.
Patent EA-022309-B1 (EA)
Title: USE OF POTASSIUM 2-(1-HYDROXYPENTYL)BENZOATE (dl-PHPB) FOR PREVENTING AND TREATING ALZHEIMER'S DISEASE
Inventor: WANG XIAOLIANG
IPC: A61P43/00
Filed: 2008-07-08
Abstract: The present invention discloses the use of potassium dl-2-(1-hydroxypentyl)benzoate in the manufacture of medicaments for preventing, relieving or treating senile dementia diseases or symptoms. The present invention also discloses a pharmaceutical composition comprising potassium dl-2-(1-hydroxypentyl)benzoate in prophylactically or therapeutically effective dose, optionally, a pharmaceutically acceptable carrier and/or adjuvant.
Patent EA-018933-B1 (EA)
Title: Benzodiazepine derivative for the treatment of hematopoietic neoplasm and leukemia
Inventor: CHEDID MARCIO
IPC: A61K31/5517
Filed: 2010-04-08
Abstract: A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproloferative disorder, or non-MLL based acoute lymphoid leukemia is provided, wherein the active agent used is the GSK-3 inhibitor 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk]-[1,4]benzodiazepine or a pharmaceutically acceptable salt or salvate thereof.
Patent EA-019875-B1 (EA)
Title: Slurry bed fischer-tropsch catalysts with silica/alumina structural promoters
Inventor: DUVENHAGE DAVID J
IPC: B01J23/78
Filed: 2010-05-28
Abstract: A method of producing a Fischer-Tropsch catalyst by preparing a nitrate solution, wherein preparing comprises forming at least one metal slurry and combining the at least one metal slurry with a nitric acid solution; combining the nitrate solution with a basic solution to form a precipitate; promoting the precipitate to form a promoted mixture, wherein promoting comprises combining the precipitate with (a) silicic acid and one or more selected from the group consisting of non-crystalline silicas, crystalline silicas, and sources of kaolin or (b) at least one selected from non-crystalline silicas and sources of kaolin, in the absence of silicic acid; and spray drying the promoted mixture to produce catalyst having a desired particle size. Catalyst produced by the disclosed method is also described.
Patent EA-019332-B1 (EA)
Title: Oral care compositions containing human recombinant interleukin-1
Inventor: PETROPAVLOV IGOR ARTUROVICH
IPC: A61K9/00
Filed: 2009-09-29
Abstract: The present invention relates to oral care compositions comprising human recombinant interleukin-1 and methods thereof for keeping oral cavity in a good condition, reducing oral malodor, and/or preventing or treating periodontal diseases. Preferably, the human recombinant interleukin-1 is human recombinant interleukin-1 alpha or beta.
Patent EA-029378-B1 (EA)
Title: Apparatus for tightening threaded fasteners
Inventor: BONAS CALVIN A
IPC: B25H1/00
Filed: 2012-02-17
Abstract: Apparatus for use with a tool assembly in operations of tightening or loosening threaded fasteners about an axis is disclosed, and in one example includes a lower clamp assembly; an upper clamp assembly; a reaction adaptor assembly; and a spring assembly formed between the upper clamp assembly and the reaction adaptor assembly. Advantageously an operator can tighten or loosen ail fasteners without having to change the initial setup of the apparatus. The lower clamp assembly eliminates the need for extra operators and heavy and bulky equipment to hold the apparatus near the fasteners. The upper clamp allows the operator to rotate the apparatus around with ease. The spring assembly stabilizes and eases vertical height adjustment of the apparatus. The reaction adaptor substantially negates reaction turning forces of the tool assembly during the operations. Drive knobs provide easy alignment of and quick and safe mounting of the tool assembly on the fasteners. Bolting operations about an axis are completed faster, cheaper and with little or no risk of operator injury.
Patent EA-032730-B1 (EA)
Title: Method for prognosticating the disease outcome of a patient diagnosed with multiple myeloma
Inventor: KUIPER ROWAN
IPC: C12Q1/68
Filed: 2012-07-12
Abstract: The invention relates to a method for prognosticating the disease outcome of a patient diagnosed with multiple myeloma by classifying said patient into a high risk or a low risk category basing on the analysis of expression of 92 gene set which includes providing a set of nucleic acid probes according to table 1 for detection of each of 92 genes corresponding to them according to table 1, contacting of the said nucleic acid probe set with a sample comprising mRNA obtained from patient's plasma cells, determining the expression levels of each individual gene from the 92 genes in the sample, normalizing the expression levels of each individual gene of 92 genes using mean/variance normalization, multiplying the normalized value for each individual gene with the beta value for each individual gene to obtain the calculated value for each individual gene, summation of the calculated values for each individual gene to obtain a single score for all genes together, classification of a patient into a high risk or low risk category basing on the fact that a score above a predetermined threshold indicates that the patient is to be classified in the high risk category and a score at or below the predetermined threshold indicates that the patient is to be classified in the low risk category. The analysis of gene expression is preferably carried out on gene chips. The beta value for each individual gene is preferably beta value according to table 1. The predetermined threshold value is preferably 0.827.
Patent EA-028069-B1 (EA)
Title: Peptide having nootropic action, compositions based thereon and methods of application thereof
Inventor: MALYSHEV ANTON VIKTOROVICH
IPC: A61P25/28
Filed: 2014-05-30
Abstract: The invention relates to medicine, in particular to peptide agents having nootropic properties. The invention is directed to broadening the range of agents for protecting central nervous system having nootropic action, effective and safe both in using in adults and children including infants. For this purpose human beta-casomorphin-7 of formula Tyr-Pro-Phe-Val-Glu-Pro-Ile is used. The invention can be used for preparing a composition for administration to newborns, babies and preschool- and school-aged children, and also for application in adolescents and adults. The invention can also be used for preparing a pharmaceutical composition, a biologically active food additive, functional nutrition products or foods for particular nutritional uses.
Patent EA-038899-B1 (EA)
Title: Vesicular formulations
Inventor: MAYO JOHN
IPC: A61P17/00
Filed: 2013-03-28
Abstract: The invention relates to the use of a vesicular formulation for the treatment of rosacea, comprising one or more phospholipids and one or more nonionic surfactants, wherein the (molar) ratio of phospholipid to surfactant is 1:3 to 30:1, wherein the formulation does not contain a nonlipid, nonsurfactant, pharmaceutically active agent, and wherein the formulation contains one or more of the following ingredients: water, co-solvents, a helating agent, a bufer, an antioxidant, a preservative, an antimicrobial agent, bactericide, a softerner, a humidifier, a lubricant and a thickening agent. The invention also relates to a method of treating rosacea comprising administering a vesicular formulation according to the invention.
Patent EA-031097-B1 (EA)
Title: Transportation apparatus and guide device
Inventor: MCCORMICK STEPHEN PETER
IPC: F16L55/18
Filed: 2013-11-15
Abstract: A sensor transportation apparatus to convey an elongate sensor assembly through a wellbore. The apparatus comprises an engagement structure to connect the sensor transportation apparatus to the sensor assembly, and one or more wheels arranged to rotate about an axis of rotation substantially perpendicular to a longitudinal axis of the sensor assembly when the transportation apparatus is connected to the sensor assembly. An orientation structure defines a form having a transverse outline which has a rotational centre, wherein the rotational centre is offset from a centroidal axis of the elongate sensor assembly.
Patent EA-036290-B1 (EA)
Title: High temperature quench system and process
Inventor: SHAFE PETER
IPC: B01J19/00
Filed: 2014-06-26
Abstract: A quench system and process for cooling high temperature gases are described. The quench system includes a frustum, or conic, shaped section having an inlet at the smaller end of the quench section and the outlet at the larger end of the quench section. The system includes spray nozzles having openings flush with the wall of the quench section. The process includes spraying a large volume of liquid in small droplets for rapid heat transfer and vaporization of the quench liquid.
Patent EA-039087-B1 (EA)
Title: Crop-protective agricultural foam and methods of using same
Inventor: MARTIN TIMOTHY M
IPC: C05G3/60
Filed: 2014-09-30
Abstract: Provided are a crop-protective agricultural foam and a method of applying said agricultural foam to seeds during planting the seeds in furrow. The agricultural foam allows improved delivery of active ingredients by the ability to deliver high amounts of an active ingredient with a low volume of a formulation used.
Patent EA-031104-B1 (EA)
Title: Pyrazole compounds and their use as t-type calcium channel blockers
Inventor: SIEGRIST ROMAIN
IPC: C07D471/04
Filed: 2015-06-02
Abstract: The invention relates to compounds of formula (I)wherein X, Y, R, R, (R)and (R)are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as T-type calcium channel blockers.
Patent EA-039414-B1 (EA)
Title: Herbicidal combination and weed control method
Inventor: SHROFF JAIDEV RAJNIKANT
IPC: A01P13/00
Filed: 2017-12-27
Abstract: The invention presents methods of controlling weeds at a particular locus using a synergistic combination of metamitron and chlorpropham.
Patent EA-033791-B1 (EA)
Title: Three-pole switch
Inventor: PONOMAREV ALEXANDER ANATOLIEVICH
IPC: H02B11/133
Filed: 2018-05-22
Abstract: The invention relates to electrical engineering, in particular to the basic elements of electrical equipment, and can be used in three-pole switches constructions mounted on trucks. The technical result is the invention of the three-pole switch of a relatively simple construction, with reduced dimensions with a greater ease of use. Three-pole switch contains three poles, a drive and a truck designed to install a switch on it and to move it inside a switchgear cubicle and comprising an electric motor having an axis, a gear, a drive shaft disposed along the axis of symmetry of the truck, coaxially with the direction of movement thereof, blocking unit of the switch movement, the electric motor with the gear is installed in a horizontal plane in a central part of the truck in such a way that the axis of the electric motor is parallel to the drive shaft, the plane of the gear coincides with a top plane of the truck, and the drive shaft is connected to the gear by means of a gear train mounted on the drive shaft.
Patent EA-037013-B1 (EA)
Title: Device for monitoring the spatial and temporal dynamics of thrombin
Inventor: KARAMZIN SERGEY SERGEEVICH
IPC: G01N33/86
Filed: 2017-11-12
Abstract: A device for monitoring the spatial and temporal dynamics of thrombin, comprising a temperature-controlled sealed chamber with a transparent window and a light trap, said chamber being filled with a fluid medium and being designed to be capable of accommodating a cuvette containing a study sample of blood plasma, and into which a clot activating insert is introduced having a substance which initiates the clotting process applied to the lower end thereof, at least one means for lighting the sample, which is designed to be capable of receiving a light scattering signal from the sample, and at least one first irradiating means designed to be capable of exciting a fluorescence signal of a special marker which forms in the sample during the cleavage of a fluorogenic substrate, pre-added to the sample, by one of the proteolytic enzymes of the clotting system, a means for optically photo/video recording light scattering/radiation from the sample, and a means for adjusting the pressure in the temperature-controlled sealed chamber, which is designed to be capable of maintaining a pressure in the chamber which is greater than atmospheric pressure, wherein the device comprises at least one second means for irradiating the sample, designed to be capable of exciting a fluorescence signal of the said marker, and wherein the at least one first irradiating means allows the sample to be irradiated in a direction perpendicular to the plane of the cuvette, and the at least one second irradiating means allows the sample to be irradiated at an angle to the plane of the cuvette.
Patent ES-2167267-B1 (ES)
Title: Dispositivo de seguridad en el acceso de monedas al validador de un telefono publico y similares.
Inventor: MARTIN GOMEZ DAMASO
IPC: G07F1/02
Filed: 2000-09-26
Granted: 2003-10-16
Abstract: Dispositivo de seguridad en el acceso de monedas al validador de un teléfono público y similares. El dispositivo incluye tres módulos (1), (2) y (3) el primero de ellos con una ranura (4) para introducción de la moneda (5), mientras que el módulo (2), que se fijo al igual que el anterior, presenta una ranura (6) para el acceso de la moneda al correspondiente validador (9) del teléfono, siendo el módulo (3) móvil y dotado de una ranura (8) susceptible de enfrentarse a la ranura (4) y a la ranura (6), quedando en desfase respecto a la otra, para permitir la introducción de la moneda y/o acceso al validador (9), impidiendo la introducción de elementos fraudulentos a través de la ranura opuesta del paso de la moneda. El dispositivo incorpora medios de detección de presencia (16) de la moneda (5) y medios de detección de posición (18) que posibilita regular de manera precisa el movimiento del módulo móvil (3).
Patent ES-2178604-B1 (ES)
Title: Encofrado curvo.
Inventor: XAMMAR BOVE PEDRO
IPC: E04G11/06
Filed: 2001-04-27
Granted: 2004-10-01
Abstract: "Encofrado curvo". Está constituido por paneles (1), formados por una placa (2) y por montantes y travesaños, y adquiere una forma combada mediante múltiples elementos tensores intermedios (8), situados entre montantes interiores (3) consecutivos, y mediante múltiples elementos tensores extremos (9), situados entre un montante final (4) y el primer montante interior (5). Los elementos tensores extremos están constituidos por una estructura en doble triángulo con dos brazos rígidos (11), que vinculan articuladamente el canto externo del montante final con el canto interno del primer montante interior asociado, y un brazo extensible telescópicamente (12), dispuesto cruzado entre los brazos rígidos. Los elementos tensores intermedios son sendas vigas extensibles, compuestas por un primer cilindro (20), aterrajado interiormente y articulado por un extremo a un montante (3), y por un vástago (35) solidario por el extremo contrario de otro montante y dotado de un filete de rosca externa (24), quequeda totalmente oculto introducido en el primer cilindro. Aplicable a la construcción de muros y paredes curvos de hormigón.
Patent ES-2190340-B1 (ES)
Inventor: MANDALUNIZ BILBAO JOSEBA
IPC: B60K15/05
Filed: 2001-05-24
Granted: 2004-12-16
Abstract: A fuel lid unit preferably used as a fuel lid for motor vehicles, which, when consisting of a body-base (2, 4), a lid (3) and a spring (8), functions efficiently. <IMAGE>
Patent ES-2185508-B1 (ES)
Title: Disposicion de seguridad integral sobre aeronaves para la proteccion de la tripulacion y el pasaje.
Inventor: VILLANUEVA GRANA JOSE RAMON
IPC: B64D45/00
Filed: 2001-10-05
Granted: 2005-03-01
Abstract: Disposición de seguridad integral sobre aeronaves para la protección de la tripulación y el pasaje. Disposición de seguridad integral sobre aeronaves para la protección de la tripulación y el pasaje, que consiste en hermetizar la cabina (2) mediante tabiques transversales (9) de seguridad, incorporando un aseo (3) en el interior de la cabina y medios de emisión a la zona del pasaje a través de boquillas (4) de un gas adormecedor receptable por el pasaje y no por la tripulación incorporada y protegida en el interior de la cabina (2) por medio del tabique (9).
Patent ES-2303737-B1 (ES)
Title: Procedimiento de diseño y fabricacion de elementos pretensados de armadura pretesa hibridos.
Inventor: MARTINEZ ABELLA FERNANDO
IPC: B28B23/02
Filed: 2003-06-02
Granted: 2009-05-01
Abstract: Procedimiento de diseño y fabricación de
elementos pretensados de  armadura pretesa híbridos, caracterizado
por el empleo de hormigones  genéricos (hormigones objetivo) en todo
el elemento salvo en las zonas  criticas. El objetivo es resolver la
patología frecuente (fisuración,  deformación o pérdidas de
pretensado excesivas) que surge al fabricar  elementos pretensados
con hormigones genéricos: hormigones  convencionales de
características mecánicas moderadas, y hormigones  no convencionales
(por ejemplo hormigones ligeros o de áridos  reciclados). De esta
forma se fabrican los elementos pretensados con los  hormigones
objetivo, exceptuando las zonas criticas, que se proyectan 
empleando un hormigón (que denominaremos hormigón de anclaje), que 
haya demostrado la suficiente capacidad resistente para asegurar el 
anclaje estable de la armadura activa y pasiva, sin que se produzca 
fisuración que pueda comprometer su durabilidad. La interfase entre 
ambos hormigones se diseña a fin de que se transmitan de forma
efectiva  las tensiones normales y rasantes entre ambos
materiales.
Patent ES-2238161-B1 (ES)
Title: Bobinado de dos polos para estator de dieciseis ranuras.
Inventor: MADORELL COSTA ROGER
IPC: H02K3/28
Filed: 2003-10-31
Granted: 2006-11-01
Abstract: Bobinado de dos polos para estator de dieciséis ranuras para la fabricación de máquinas tanto monofásicas como bifásicas de dos polos que realizado sobre un estator de dieciséis ranuras, que tiene dos polos, con un total de 8 bobinas, cuatro para trabajo y cuatro bobinas para arranque, hay un total de cuatro grupos de bobinas, siendo el número de ranuras por polo y fase de ocho, y en donde el paso de todas las bobinas es de 1/6 quedando imbricadas entre sí las bobinas tanto las bobinas de arranque como de trabajo, todo ello de forma que la altura de la cabeza del bobinado entre dos ranuras consecutivas no precisa más superficie que la equivalente a tres ranuras, por lo que es posible el bobinado de forma automática y no manual, siendo dicho bobinado seguro, eficaz consiguiendo con el presente bobinado una mejora en el rendimiento máximo gracias una nueva distribución de armónicos.
Patent ES-2284294-B1 (ES)
Title: Maquina exprimidora de frutos citricos de tamaño reducido.
Inventor: MENGUAL MENGUAL JOAQUIN
IPC: B30B9/02
Filed: 2003-10-31
Granted: 2009-04-16
Abstract: Máquina exprimidora de frutos cítricos de tamaño
reducido, de las que utilizan juegos de tambores rotatorios 
macho-hembra, caracterizada por estar compuesta por
un único tambor hembra y un único tambor macho, por una  cuchilla de
orientación automática y por un sistema de péndulo retenedor - pieza
volteadora, que es el que evita el uso  del segundo juego de
tambores, al voltear el medio fruto restante después del corte hasta
la siguiente oquedad superior  del tambor hembra. La máquina, además
de mantener las prestaciones de servicio que sus hermanas de mayor
tamaño,  mejora las condiciones higiénicas, debido a una disposición
adecuada del péndulo retenedor, una puerta nervada de  entrada de
frutos y un depósito de cortezas y jarra de zumo de diseño integrado
aislados del exterior, todo lo cual la  hacen especialmente idónea
para locales de hostelería que no cuentan con gran espacio.
Patent ES-2246689-B1 (ES)
Title: Escuadra perfeccionada de sujecion o ensamblaje para carpinteria de aluminio.
Inventor: BLAZQUEZ CANO MANUEL
IPC: E06B3/96
Filed: 2004-03-05
Granted: 2007-05-16
Abstract: Escuadra perfeccionada de sujeción o ensamblaje
para carpintería de aluminio constituida a partir de la escuadra
propiamente dicha (1), de una sola pieza, dotada de una caja
configurada con una determinada inclinación, para permitir el
desplazamiento en su interior de la pieza de apriete (2); al subir o
bajar ésta, se desplaza, permitiendo la sujeción de los perfiles, al
encajarse en la caja (4) dispuesta a tal efecto en dichos perfiles,
para, posteriormente, apretar la pieza de apriete (2) mediante unos
tornillos convencionales. 
     La pieza de apriete (2), opcionalmente, puede
llevar incorporado un muelle de tipo convencional (5) para facilitar
la subida y bajada automática de la misma en la caja de la
escuadra.