baber/WOPTO huggingface dataset:
Patent HU-E034553-T2 (HU)
Title: Optimization of human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
Inventor: LONBERG NILS
IPC: C07K16/28
Filed: 2013-07-02
Abstract: The present invention provides isolated monoclonal antibodies that specifically bind LAG-3, and have optimized functional properties compared to previously described anti-LAG-3 antibodies, such as antibody 25F7 (US 2011/0150892 A1). These properties include reduced deamidation sites, while still retaining high affinity binding to human LAG-3, and physical (i.e., thermal and chemical) stability. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided, as well as immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies. The present invention also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which the antibodies are co-administered with at least one additional immunostimulatory antibody, is also provided.
Patent TR-200000722-T2 (TR)
Inventor: LEHTOLA VELL-MATTI
IPC: A61K31/663
Filed: 1998-09-18
Abstract: Composition comprising a salt of dichloromethylene bisphosphonic acid (I; clodronate) and silicified microcrystalline cellulose as an oral solid dosage form, is new : Independent claims are also included for the manufacture of the oral dosage forms. ACTIVITY : Hypocalcemic.
Patent TR-200002660-T2 (TR)
Title: Durultma tanklarında yüzer maddenin toplanması için düzenek
Inventor: SUHR PATRICK
IPC: B01D21/24
Filed: 1999-02-09
Abstract: Bulusun konusu, artik su aritma tesislerinde durultma tanklari üzerinde olusan yüzer maddenin toplanmasi için tankin üstünde, bitimine takilan döner perdahlayici seklinde düzenektir; boylamasina yariga sahip ve bir ucunda kapali ve digerinde açik olan yüzen bir akis boru; akis borusunun boyunca kaynaklanmis batik, tercihen parçali kovan, boru ve kovan grubunu 360o boyunca, her bir eksensel dönüsünde yüzer maddenin kovan tarafindan toplanacagi sekilde devresel olarak hareket ettiren motordan olusmaktadir ki motorun yüzey akis borusuna göre konumu, yüzer maddenin boru içine borunun boylamasina yarigi araciligiyla dökülecegi ardindan yerçekimi altinda yüzen borunun açik ucundan uzaklastirilacagi sekildedir.
Patent TR-200003224-T2 (TR)
Title: İyi huylu prostat hiperplasianın tedavisinde alfa 1A reseptörü antagonistleri olarak yararlı olan ftalimido arilpiperazinler
Inventor: GEE-HONG KUO
IPC: A61P13/10
Filed: 1999-02-19
Abstract: Bu bulus bir ftalimido arilpiperazin türevleri serisi, bunlari içeren farmasötik bilesimler ve bunlarin yapiminda kullanilan islemler ve ara-bilesiklerle ilgilidir. Bulusun bilesikleri seçici olarak iyi huylu prostat hiperplasiada mevcut olan bir reseptör olan alfa 1a adrenerjik reseptörüne baglanmayi inhibe eder. Dolayisiyla bilesikler bu hastaligin tedavisinde potansiyel olarak yararlidir.
Patent TR-200102644-T2 (TR)
Title: Suda çözünür bir paket imal etme yöntemi.
Inventor: HARBOUR RICHARD
IPC: B65B11/50
Filed: 2000-03-07
Abstract: Söz konusu bulus isi tatbik edilerek meydana getirilen bir paket imal etme yöntemi ile ilgilidir. Yöntem öncelikle üzerinde asgari olarak bir tane oyuk bulunan bir biçim verme kalibi üzerine bir ilk film tabakasi yerlestirilmesi bunu takiben söz konusu filmin isitilmasi suretiyle filmin oyuk içinde bir bir bos alan yaratan bir kalip olusturulmasinin saglanmasi ve elde edilen bu asgari bir adet bos alan içine bir bilesim konulmasi ve bunu müteakip bu asgari bir oyuk üzerine bir ikinci tabaka film kapatilarak asgari bir adet kapali paket elde edilmesi basamaklarindan mürekkeptir. Tesekkül ettirilen her bir bos alan oyuklarin içinden tatbik edilen vakum vasitasi ile tesekkül ettirildigi ilk konumda sabit tutulur.
Patent TR-200401979-T2 (TR)
Inventor: FITZPATRICK P JOHN
IPC: B63B25/14
Filed: 2003-03-21
Abstract: A marine gas storage and transport system formed of small diameter steel pipe, which is coiled and stacked in a specific manner. The system is suitable for use on top of a barge or inside the holds of a ship, when contained within a secondary containment system. Various ways of stacking and coiling coiled pipe are disclosed. Specific materials for making the pipe are also disclosed.
Patent DE-602004000920-T2 (DE)
Inventor: HALLIDAY ANDREW
IPC: B65D85/804
Filed: 2004-01-23
Granted: 2006-12-07
Abstract: A cartridge (1) containing one or more beverage ingredients (200) and being formed from substantially air- and water-impermeable materials, the cartridge comprising an outer member (2) defining a storage chamber (130; 134) in which is stored the one or more beverage ingredients and an inner member (3) having a discharge spout (43) forming an outlet (122) for outflow of beverage formed from the one or more beverage ingredients, characterised in that the inner member (3) forms a load-bearing member. <IMAGE>
Patent DE-602004013037-T2 (DE)
Inventor: XIA ERNING
IPC: A61L12/08
Filed: 2004-11-29
Granted: 2009-05-14
Abstract: Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more saccharides in combination with one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.
Patent DE-3855921-T3 (DE)
Inventor: LAWN RICHARD MARK
IPC: C12N15/12
Filed: 1988-02-12
Granted: 2005-03-10
Abstract: DNA isolates coding for tissue factor protein and derivatives thereof and methods of obtaining such DNA and producing tissue factor protein and derivatives thereof using recombinant expression systems for use in therapeutic compositions for the treatment of coagulation disorders. <IMAGE>   <IMAGE>
Patent DE-60014360-T3 (DE)
Inventor: ANDERSEN JOHN G
IPC: F04B43/12
Filed: 2000-05-09
Granted: 2009-10-22
Abstract: A peristaltic fluid pump having a suction side and a pumping side. The pump includes a pump housing having a mainly arcuate support surface, a flexible tube extending along this surface, a rotor having two opposite rollers for during operation rolling over the flexible tube along an entrance section where the tube is successively compressed, a pumping section extending across an angle of an arc of less than 180°, and an exit section where the compression successively ends, and a motor for during operation making the rotor rotate. The arcuate support surface is shaped in such a way that the rearmost and foremost rollers do not operate in synchronous phase opposition during their passage of the entrance and exit section. The peristaltic fluid pump is capable of pumping a fluid with less pressure difference and compressive pulsations in the fluid than previously known, making it especially suitable for pumping a patient's blood through a dialyzer.
Patent DE-60104415-T3 (DE)
Inventor: LEISNER HENRIK
IPC: A61F5/449
Filed: 2001-05-08
Granted: 2013-09-05
Abstract: A carrier device including a flexible adhesive base plate with an opening for securing the carrier device to a user's skin around a stoma, and a substantially circumferential flange made of a flexible material and adapted for removable and adhesive connection with a coupling element of an ostomy collecting bag. The outer portion of the flange is free to move relative to the base plate and is more flexible than the inner portion of the flange. As a result, the outer portion can absorb movements between the carrier device and the collecting bag, thus protecting against peeling of the bond between the flange members as well as providing a cushioning effect against forces acting on the periphery of the flanges, while the less flexible inner portion can withstand deformations originating from the adhesive base plate.
Patent DE-69131692-T3 (DE)
Inventor: RATTAN SURESH
IPC: A61K31/52
Filed: 1991-05-16
Granted: 2004-09-23
Abstract: Ameliorating the adverse effects of ageing on mammalian cells comprises; contacting the cells with a compsn. that contains a 6-(substd. amino) purine cytokinin in a concn. sufficient to ameliorate the adverse effects of ageing. The rate of development of characteristics of ageing is reversed or slowed, and the growth rate and total proliferative capacity of the cells, after contact with the compsn., is the same as prior to contact. Pref. the cytokinin is of formula (I). In (I) R1 = furfuryl, phenyl, benzyl, 4-6C n-alkyl, cyclohexylmethyl, (3-hydroxymethyl-3-methyl)allyl or 3,3-dimethylallyl. (I) is most esp. furfuryladenine (kinetin).
Patent DE-69321611-T3 (DE)
Inventor: CALEY DAVID
IPC: F02M61/06
Filed: 1993-02-17
Granted: 2004-03-25
Abstract: PCT No. PCT/AU93/00074 Sec. 371 Date Jul. 19, 1994 Sec. 102(e) Date Jul. 19, 1994 PCT Filed Feb. 17, 1993 PCT Pub. No. WO93/16282 PCT Pub. Date Aug. 19, 1993An injector nozzle for a fuel injected internal combustion engine having a selectively openable nozzle for the delivery of fuel to the engine combustion chamber, the nozzle comprising a port having an internal annular surface and a valve member having an external annular surface coaxial with respect to the internal annular surface of the port. The valve member being axially movable relative to the port to selectively provide an annular passage therebetween for the delivery of the fuel or sealed contact therebetween to prevent the delivery of fuel. The valve member has a coaxial projection extending beyond the extremity of the external annular surface and positioned so the fuel plume issuing from the nozzle will follow a path based on the external surface of the projection and will pass therealong that external surface to issue from the lower extremity thereof in a substantially coaxial relation to the nozzle. The projection preferably is necked down immediately adjacent the valve member and thereafter is of a converging circular shape, generally of an inverted truncated conical shape. The projection provides a surface which aids in the control of the fuel plume shape and corrects disturbances to that shape caused by deposits in or on the surface of the nozzle port or valve member.
Patent DE-69401770-T3 (DE)
Inventor: FAVAROSSA EDOARDO
IPC: F16D1/033
Filed: 1994-11-04
Granted: 2004-07-01
Abstract: The present invention relates to a tubular element (2) for supporting washing brushes (20), which has been specifically designed for motor vehicle automatic washing systems, the main feature of which is that the tubular element (2) comprises an extruded tubular body (2), of circular, or square or polygonal cross-section, which defines integral longitudinal ribs (3) on the inner surface thereof, the longitudinal ribs (3) being hollow so as to define recesses (4) for engaging therein screws for connecting the coupling flange (10) of an electric motor (11) for rotatively driving the tubular body (2). <IMAGE>
Patent DK-1123823-T3 (DK)
Inventor: KUEHL MANFRED
IPC: F02C6/18
Filed: 2000-12-23
Granted: 2008-04-14
Abstract: The device has an auxiliary small energy generator (2) on the vehicle in the form of a gas turbine that produces hot air with a compressor on the turbine for the crew compartment (3) in the vehicle. The exhaust flow (13) from the turbine is fed via a pipeline (10) into the engine compartment (4) to heat up the engine compartment. The energy generator can contain an electricity generator as an auxiliary electricity supply for the vehicle.
Patent DK-1240852-T3 (DK)
Inventor: LAMBERTZ BERND
IPC: A47C27/14
Filed: 2001-03-15
Granted: 2005-03-14
Abstract: The mattress comprises a layer of visco-elastic foam (1). A first resilient fabric (2) partially covers a first face of the foam and a second fabric (3) partially covers the second opposite face of the foam. Sewing points (4) extending between the two fabrics pass through the foam layer.
Patent DK-1188014-T3 (DK)
Inventor: ESPINASSE PHILIPPE
IPC: F16L11/16
Filed: 2001-04-18
Granted: 2003-02-24
Abstract: A flexible metal tube with closed section and a flexible pipe comprising such a metal tube, comprising a strip with substantially constant thickness and wound helically around an axis, the strip includes at least a closed section having walls formed by portions of a common turn of the strip, the closed section includes an upper wall and a lower wall and the section is arranged at one end of said strip while the other end terminates in a free edge. The closed section is trapezoidal in cross-section. A bulge radially oriented towards the upper wall of the closed section is provided between the closed section and the free edge of the stirrup. The invention is in particular applicable to flexible tubular pipes.
Patent DK-1309355-T3 (DK)
Inventor: DARD MICHEL
IPC: A61P31/04
Filed: 2001-08-02
Granted: 2008-08-25
Abstract: The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO-CH2-(CH2)n-PO3H2)2(I), -Lys-[-Lys-(CO-CH2-(CH2)a-PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO-CH2-(CH2)n-PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
Patent DK-1404980-T3 (DK)
Inventor: FICH PREBEN BO
IPC: F16B12/44
Filed: 2001-09-11
Granted: 2006-06-12
Abstract: A connecting device (101) for releasable connection of a tube or rod members (102), comprises a nodal body part (103) having at least one projecting, at least partially wedge-shaped mandrel member (104) and an at least partially wedge-shaped insertion member (105) for form-fit mounting in a tubular section (102) to provide an expansion joint by axial traction of the insertion member (105) towards the mandrel member (104). The mandrel member (104) and the insertion member (105) may advantageously be designed as part-cylindrical shell members having longitudinal edge surfaces (11, 112, 117, 118) forming an angle (v) with the direction of generatrix of the part-cylindrical member. The traction means comprise a traction member (107) retained, secured against turning in the insertion member and engaging an elongate tightening member (106) having a head (108) for engagement by a tightening means introduced through the nodal body part (3), the tightening member (106) being retained against axial displacement with respect to the mandrel member (104).
Patent DK-1279779-T3 (DK)
Inventor: CELLI ROBERTO
IPC: E04F19/08
Filed: 2002-04-22
Granted: 2008-11-10
Abstract: In a plasterboard panel (1), an inspection opening (2) and a related closure element (3), comprising a first plasterboard plate (30) having dimensions substantially corresponding to those of the inspection opening (2) and thickness substantially equal to the thickness of the panel (1), are flared upwards and their respective lower faces (21, 31) have exactly the same shape and dimensions. The inspection opening (2) has segments (22) of inner peripheral edge (23) inclined by a predetermined minimum angle ( alpha ) relative to the perpendicular to the panel (1), for the abutment of corresponding, counter-shaped portions (32) of outer peripheral edge (33) of the closure element (3) inclined by the same angle ( alpha ), in order stably to support the element (3) in the position of insertion in the inspection opening (2) with its own lower face (31) substantially coplanar to a lower face (10) of the panel (1). Preferably, the segments (22) of the inner peripheral edge (23) are in mutual contact and together involve the whole inner peripheral edge (23), the portions (32) of the outer peripheral edge (33) being, correspondingly, also in mutual contact and together involving the whole outer peripheral edge (33) of the closure element (3). <IMAGE>
Patent DK-1366275-T3 (DK)
Inventor: VIITAMAEKI TAPIO
IPC: F02B53/00
Filed: 2002-01-29
Granted: 2009-08-31
Abstract: A rotary combustion engine includes a driving eccentric ring arranged between a non-rotary outer casing and a non-rotary inner casing for rotating a power shaft situated inside the inner casing. In order to drive the eccentric ring, a combustion chamber arrangement is provided between the inner and the outer non-rotary casings for burning a mixture of fuel and air supplied thereto, the power shaft being provided with an eccentric element. In order to minimize the number of rotating components, a second eccentric ring is mounted by a bearing around the power shaft inside the aforementioned non-rotary inner casing, this second ring being coaxial with and fixed to the driving eccentric ring, and the eccentric ring arrangement being a substantially non-rotary unit that only performs an eccentric motion, which makes the power shaft rotate.
Patent DK-1381869-T3 (DK)
Inventor: HOLTLUND JOSTEIN
IPC: G01N33/72
Filed: 2002-04-10
Granted: 2008-12-01
Abstract: The invention provides a kit for a glycated haemoglobin assay, said kit comprising: a porous membrane capable of retaining precipitated haemoglobin; a first reagent comprising zinc ions in aqueous basic solution or comprising a water soluble zinc compound; a second reagent comprising a chromophore-boronic acid conjugate; and optionally, an aqueous washing reagent; wherein at least one of the first and second reagents further comprises a surfactant capable of lysing erythrocytes, and wherein said second reagent if liquid is acidic.
Patent DK-1361882-T3 (DK)
Inventor: WOHLFART PAULUS
IPC: A61P11/06
Filed: 2002-02-12
Granted: 2007-03-12
Abstract: A method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan- 2-yl benzamide according to the formula (I)
Patent DK-1521744-T3 (DK)
Inventor: BONDOUX MICHEL
IPC: A61P37/08
Filed: 2003-06-12
Granted: 2009-07-13
Abstract: N-((N-(4-Amidinobenzyl)-N-methylcarbamoyl)-alkyl)-arylsulfonamides (I) are new.  Aryl sulfonamide derivatives of formula (I) and their acid addition salts are new. R1  =  aromatic nucleus (optionally substituted by one or more of halo, 1-3C alkyl, 1-3C alkoxy, NO2, CN, CF3 or OCF3);  R2  =  H or 1-4C alkyl (optionally substituted by phenyl, CONH2 or one or more F);  R3  =  H or OH;  R4  =  H;  or R3 + R4  =  -CH=N- or 2-4C alkylene;  R5  =  H or 1-3C alkyl;  R6  =  H or halo;  Y  =  optionally unsaturated 2-4C alkylene (optionally interrupted by O).  An Independent claim is included for the preparation of (I).
Patent DK-1444925-T3 (DK)
Inventor: GROENWEGHE RONALD JOSE
IPC: A47C27/14
Filed: 2004-01-28
Granted: 2007-07-09
Abstract: The piercing die (16) has several solid blocks (18) each provided with several holes (19). A punch (14) is provided opposite to the piercing die. Independent claims are included for the following: (1) series of perforations forming method; (2) mattress; and (3) usage of mattress.
Patent DK-1505381-T3 (DK)
Inventor: GRUEBLER ROBERT DR
IPC: G01F1/72
Filed: 2004-07-08
Granted: 2008-02-25
Abstract: The presence of gas bubbles within the measurement zone of an enclosed cell for determination of physical or chemical properties of a liquid is detected by also measuring the electrical conductivity S under two different pressure conditions, and comparing the value delta S = (S1-S2) / S1 against a permitted threshold value k. The presence of gas bubbles within the measurement zone of an enclosed cell for determination of physical or chemical properties of a liquid is detected by also measuring the electrical conductivity S under two different pressure conditions, and comparing the value delta S = (S1-S2) / S1 against a permitted threshold value k. Electrical conductivity measurements S1 and S2 are made at, respectively, atmospheric pressure and 100-400 mbar, preferably 250 mbar. Comparison of the standardised value delta S / S1 = (S1-S2) / S1 with a permitted threshhold value k for the liquid, provides indication of the validity of the subsequent measurements.
Patent DK-1677823-T3 (DK)
Inventor: BLUMENFELD ANDREW M
IPC: A61K38/48
Filed: 2004-10-26
Granted: 2009-02-16
Abstract: This application relates to methods and medicaments for preventing or treating neuropsychiatric disorder and/or neurological disorder including a neurological disorder mediated by the thalamus. Neuropsychiatric disorders and/or neurological disorders, including a thalamically mediated disorder can be treated by peripheral administration of a medicament containing a botulinum toxin to or to the vicinity of a trigeminal nerve, thereby preventing or treating a neurological disorder and/or neuropsychiatric disorder.
Patent DK-1618889-T3 (DK)
Inventor: D HONDT ERIK
IPC: A61K39/00
Filed: 2000-09-27
Granted: 2011-06-06
Abstract: The invention provides a monovalent influenza vaccine comprising a low dose of egg-derived influenza virus antigen from an influenza virus strain that is associated with a pandemic outbreak or has the potential to be associated with a pandemic outbreak, in combination with an aluminium adjuvant. The invention also provides vaccine kits comprising a combination of a parenteral and a mucosal influenza vaccine, wherein the combined dose of antigen is no more than the conventional antigen dose. Also provided are methods for preparing the vaccines.
Patent DK-1773856-T3 (DK)
Inventor: WANG PEIYUAN
IPC: C07B37/00
Filed: 2005-07-21
Granted: 2012-05-21
Abstract: The present invention provides a method to prepare anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-²-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
Patent DK-1827427-T3 (DK)
Inventor: FEENSTRA ROELOF W
IPC: C07D413/12
Filed: 2005-12-06
Granted: 2008-11-24
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
Patent DK-1927390-T3 (DK)
Inventor: SIRET BERNARD
IPC: B01D46/46
Filed: 2007-11-09
Granted: 2011-04-18
Abstract: The method involves acquiring a measurement of a pressure drop signal (DP) across a bag filter, and filtering the signal by digital or analog unit to obtain a filtered signal (DP *>). A measurement of the filtered signal corrected by a flow value is calculated using a savisky-golay algorithm. A declogging sequence is initiated, when DP is greater than DP3, a declogging is not initiated from tau minutes or DPc is greater than DP2, where the DP3 is chosen in a range of 1500-2500 Pascal, DP2 is chosen in a range of 1000-2000 Pascal, and tau is chosen in a range of 15-90 minutes.
Patent DK-2089343-T3 (DK)
Inventor: CARELL THOMAS
IPC: C07B61/00
Filed: 2007-10-31
Granted: 2011-10-24
Abstract: The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.