Patent SG-11201408228Q-A (SG)
Title: Dual receptor antagonistic antigen-binding proteins and uses thereof
Inventor: HAN HUIQUAN
IPC: C07H21/04
Filed: 2013-06-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188448 A3 (51) International Patent Classification: C12P 21/08 (2006.01) C07H 21/04 (2006.01) C07K16/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/045245 11 June 2013 (11.06.2013) English (30) Priority Data: 61/658,237 11 June 2012 (11.06.2012) English US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). (72) Inventors: HAN, Huiquan; C/o Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). ZHOU, Xiaolan; C/o Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). CHEN, Qing; C/o Amgen Inc., One Amgen Center Drive, Thou­ sand Oaks, CA 91320-1799 (US). TSAI, Mei-Mei; C/o Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). (74) Agents: HUBL, Susan et al.; Fenwick & West LLP, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) [Continued on next page] (54) Title: DUAL RECEPTOR ANTAGONISTIC ANTIGEN-BINDING PROTEINS AND USES THEREOF FIG 4 A 00 00 00 28n 24- * 20- 16- •12- £ 8- I 1 2 3 Time (week) 1x/wk, SC, 4 wks n=8 per group *: p<0.05 P<0.01 ***: p<0.QQ1 24% 1 17% 1 3 rrsg/Ky iUrog/KQ 30mg/kg 23% T 27% t T-H o CJ O (57) Abstract: This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases. The dual receptor antibodies may comprise an antibody ActRII to receptors and may be used to treat pathological condition. The pathological conditions can comprise muscle wasting diseases or any disease that requires stimulation of muscle growth. WO 2013/188448 A3 I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll llll lllll lllll lllllll llll llll llll (88) Date of publication of the international search report: 10 April 2014