Patent GB-445739-A (GB)
Title: Process for the manufacture of mercury compounds containing nitrogen
IPC: C07F3/10
Filed: 1934-07-13
Abstract: Organo-mercury compounds, in which the mercury is connected on the one hand to an alkoxyalkyl residue and on the other to a nitrogen atom, are prepared by reacting an alkoxyalkyl mercury hydroxide or salt, preferably in a solvent, with a nitrogenous compound having attached to a nitrogen atom a hydrogen atom which is replaceable by or is replaced by an alkali or other metal.  The organo-mercury starting material may be produced in situ.  The products may be made up into bactericidal and fungicidal preparations for use as preservatives or coatings for ship bottoms, and for disinfection, combating parasites, preserving wood, or immunizing seed grain.  In some cases, the preparations may contain a mixture of the reacting materials which then interact in the presence of moisture.  The examples describe the interaction of: (1) methoxyethyl-mercury chloride and potassium phthalimide or sodium p-toluene-sulphochloroamide; (2) methoxyethylmercury chloride or bromide with sodium 5 : 5-diethylbarbiturate, with or without the presence of talc; (3) methoxyethylmercury hydroxide and 5 : 5-diethylbarbituric acid; (4) methoxyethylmercury acetate or bromide with sodium 5-phenyl-5-ethyl-barbiturate, or the mercury hydroxide with the barbituric acid; (5) methoxyethylmercuric hydroxide and o-benzoic acid sulphimide; (6) methoxyethylmercuric hydroxide and p-toluenesulphamide, cyanamide (\ba1/2\be mol.), dicyandiamide, hydrazoic acid or carbazole; the hydrazoic acid may be replaced by its sodium salt, in which case the mercury acetate is used; (7) methoxyethylmercury chloride with sodamide or the sodium compounds of aniline, toluidine, naphthylamine and diphenylamine.  In the above examples water, ether and benzene are employed as solvents, except in a few cases where no solvent is present.  An example is also given, according to which ethylene is introduced into a methyl alcohol solution of mercury acetate and sodium 5 : 5-diethylbarbiturate dissolved in caustic soda then added; the product comprises methoxyethylmercury-5 : 5-diethylbarbituric acid.ALSO:Organo-mercury compounds, in which the mercury is connected on the one hand to an alkoxyalkyl residue and on the other to a nitrogen atom, are prepared by reacting an alkoxyalkyl mercury hydroxide or salt, preferably in a solvent, with a nitrogenous compound having attached to a nitrogen atom a hydrogen atom which is replaceable by or is replaced by an alkali or other metal.  The organo-mercury starting material may be produced in situ.  The products may be made up into bactericidal and fungicidal preparations for use as preservatives or coatings for ship bottoms, and for disinfection, combating parasites, preserving wood, or immunizing seed grain.  In some cases, the preparations may contain a mixture of the reacting materials which then interact in the presence of moisture.  The examples describe the interaction of (1) methoxyethylmercury chloride and potassium phthalimide or sodium p-toluene-sulphochloroamide; (2) methoxyethylmercury chloride or bromide with sodium 5 : 5- diethylbarbiturate, with or without the presence of talc; (3) methoxyethylmercury hydroxide and 5 : 5-diethylbarbituric acid; (4) methoxyethylmercury acetate or bromide with sodium 5-phenyl-5-ethyl-barbiturate, or the mercury hydroxide with the barbituric acid; (5) methoxyethylmercuric hydroxide and o-benzoic acid sulphimide; (6) methoxyethylmercuric hydroxide and p-toluenesulphamide, cyanamide (\ba1/2\be mol), dicyandiamide, hydrazoic acid or carbazole; the hydrazoic acid may be replaced by its sodium salt, in which case the mercury acetate is used; (7) methoxyethylmercury chloride with sodamide or the sodium compounds of aniline, toluidine, naphthylamine and diphenylamine. In the above examples water, ether and benzene are employed as solvents, except in a few cases where no solvent is present.  An example is also given, according to which ethylene is introduced into a methyl alcohol solution of mercury acetate and sodium 5 : 5-diethylbarbiturate dissolved in caustic soda when added; the product comprises methoxyethylmercury-5 : 5-diethylbarbituric acid.ALSO:Organo-mercury compounds, in which the mercury is connected on the one hand to an alkoxyalkyl residue and on the other to a nitrogen atom, are prepared by reacting an alkoxyalkyl mercury hydroxide or salt, preferably in a solvent, with a nitrogenous compound having attached to a nitrogen atom a hydrogen atom which is replaceable by or is replaced by an alkali or other metal.  The organo-mercury starting material may be produced in situ.  The products may be made up into bactericidal and fungicidal preparations for use as preservatives, and for disinfection, combating parasites, preserving wood, or immunizing seed grain. In some cases, the preparations may contain a mixture of the reacting materials which then interact in the presence of moisture during use.  The examples describe the interaction of (1) methoxyethylmercury chloride and potassium phthalimide or sodium p-toluene-sulphochloramide; (2) methoxy-ethyl-mercury chloride or bromide with sodium 5 : 5-diethylbarbiturate, with or without the presence of talc; (3) methoxyethylmercury hydroxide and 5 : 5-diethylbarbituric acid; (4) methoxyethylmercury acetate or bromide with sodium 5-phenyl-5-ethyl-barbiturate, or the mercury hydroxide with the barbituric acid; (5) methoxyethylmercuric hydroxide and o-benzoic acid sulphimide; (6) methoxyethylmercuric hydroxide and p-toluenesulphamide, cyanamide ( 1/2 mol), dicyandiamide, hydrazoic acid or carbazole; the hydrazoic acid may be replaced by its sodium salt, in which case the mercury acetate is used; (7) methoxyethylmercury chloride with sodamide or the sodium compounds of aniline, toluidine, naphthylamine and diphenylamine.  In the above examples water, ether and benzene are employed as solvents, except in a few cases where no solvent is present.  An example is also given, according to which ethylene is introduced into a methyl alcohol solution of mercury acetate and sodium 5 : 5-diethylbarbiturate dissolved in caustic soda then added; the product comprises methoxyethylmercury-5 : 5-diethylbarbituric acid.