Patent SG-11201810801Q-A (SG)
Title: Brain delivery protein
Inventor: LANNFELT LARS
IPC: A61K39/00
Filed: 2017-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111110111011111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/011353 Al 18 January 2018 (18.01.2018) W I P0 I PC T (51) International Patent Classification: (74) Agent: AWAPATENT AB; Box 45086, 104 30 Stockholm CO7K 16/18 (2006.01) A61K 39/00 (2006.01) (SE). C07K 16/28 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2017/067727 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 13 July 2017 (13.07.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (25) Filing Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, WV, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 1651065-3 14 July 2016 (14.07.2016) SE TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: BIOARCTIC AB [SE/SE]; Warfvinges vag 35, (84) Designated States (unless otherwise indicated, for every 112 51 Stockholm (SE). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: LANNFELT, Lars; c/o BioArctic AB, War- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, fvinges vag 35, 112 51 Stockholm (SE). SEHLIN, Dag; TM), European (AL, AT, BE, BG, DE, DK, — CH, CY, CZ, Basarbovagen 1, 752 73 Uppsala (SE). HULTQVIST, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Uppsala (SE). Greta; Hjalmar Brantingsgatan 2b, 753 27 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, SYVANEN, Stina; Akerholmsvagen 14, 755 98 Uppsala TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — (SE). KM, ML, MR, NE, SN, TD, TG). = = Title: BRAIN DELIVERY PROTEIN (54) = al = = = = = = = = = A B 1-1 .4 in en Figure 1 M Il (57) : The present invention relates to a brain delivery protein, comprising a target binding antibody which binds to a target 1-1 O in a mammalian brain; two carrier moieties, each of which being capable of monovalent interaction with a protein expressed on a -- -- GC blood brain barrier (BBB) endothelial cell, wherein each of said carrier moieties is linked to a C-terminal end of the target binding antibody. The present invention moreover relates to use of such brain delivery proteins in therapy or diagnosis or for research of e.g. 0 neurodegenerative disorders, and other brain diseases. ei C [Continued on next page] WO 2018/011353 Al DIII Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of