baber/WOPTO huggingface dataset:
Patent WO-2020037016-A1 (WO)
Title: Protein fragmentation control strategy by re-oxidation in downstream chromatography
Inventor: TAN ZHIJUN
IPC: C07K1/04
Filed: 2019-08-14
Abstract: Methods for the production of high purity recombinant protein such as monoclonal antibodies (mAb) using disulfide bond re-oxidation are provided. In particular, the present disclosure provides methods for converting partial molecules (e.g., antibody fragments) to full molecules (e.g., full antibodies) comprising admixing a starting solution comprising the partial molecules with a redox buffer comprising a redox pair which comprises at least one thiol reducing agent (e.g., cysteine) and at least one thiol oxidizing agent (e.g., cystine), wherein the redox buffer re-oxidizes the partial molecules to full molecules. The disclosed methods can be used, e.g., to prevent or mitigate the formation of partial molecules during protein purification, or to reprocess or rescue a solution comprising partial molecules (e.g., a partially degraded pharmaceutical formulation).
Patent WO-2020046793-A1 (WO)
Inventor: PASSNO CHRISTINA
IPC: C07K16/00
Filed: 2019-08-26
Abstract: In situ  Raman spectroscopy methods and systems for characterizing or quantifying a protein purification intermediate and/or final concentrated pool during production or manufacture are provided. In one embodiment,  in situ  Raman spectroscopy is used to characterize or quantify protein purification intermediates critical quality attributes during downstream processing (i.e., after harvest of the protein purification intermediate). For example, the disclosed  in situ  Raman spectroscopy methods and systems can be used to characterize and quantify protein purification intermediates as the protein purification intermediates are purified, condensed, or otherwise formulated into the final drug product to be sold or administered
Patent WO-2020047137-A1 (WO)
Inventor: PULEO CHRISTOPHER MICHAEL
IPC: A61N1/36
Filed: 2019-08-28
Abstract: The subject matter of the present disclosure generally relates to techniques for applying mechanical or ultrasound energy to a region of interest 44 in a subject to induce modulation of one or more nerve pathways. The region of interest may include at least a portion of a nerve ganglion.
Patent WO-2020060957-A1 (WO)
Inventor: BESTIC MICHAEL
IPC: G01F1/37
Filed: 2019-09-17
Abstract: A fluid monitoring module includes a flow sensing device and a controller disposed in an enclosure. The flow sensing device includes a body including an inlet port, an outlet port, an upstream sensor port, a downstream sensor port, and a flow passage disposed between the inlet port and the outlet port, and between the upstream sensor port and the downstream sensor port. A first fluid sensor is assembled with the upstream sensor port, and a second fluid sensor is assembled with the downstream sensor port, The controller is in circuit communication with the first and second fluid sensors for receiving at least one of pressure indicating signals and temperature indicating signals from each of the first and second fluid sensors, and for measuring fluid data based on the received signals.
Patent WO-2020072468-A1 (WO)
Inventor: ROCKLEY PAUL
IPC: A61N1/36
Filed: 2019-10-01
Abstract: Des procédés et des dispositifs illustratifs permettent de fournir un stimulus à l'œil pour traiter des troubles de la vision. L'invention concerne également des systèmes et des procédés de rétroaction concernant le stimulus lui-même, ainsi que l'effet dudit stimulus sur le patient. Divers exemples peuvent comprendre des thérapies pour des troubles de la vision qui peuvent évoluer jusqu'à la cécité, telles que la dégénérescence maculaire ou d'autres maladies et processus pathologiques.
Patent WO-2020077126-A1 (WO)
Inventor: ZEILER JEFFREY
IPC: A47L9/00
Filed: 2019-10-10
Abstract: A cell module assembly includes multiple lithium-ion battery cells connected in parallel and an electronic controller. The electronic controller is programmed to receive useful life data for a useful life indicator of the battery cells, save the life data to memory to create a life data history, determine a life measurement based on the life data history, compare the life measurement to a first end of life threshold, determine if the life measurement has met the first end of life threshold, provide a first end of life output indicating that the life measurement has met the first end of life threshold, compare the life measurement to a second end of life threshold, determine if the life measurement has met the second end of life threshold, and provide a second end of life output indicating that the life measurement has met the second end of life threshold.
Patent WO-2020081488-A1 (WO)
Title: Frame for auto interior display panel
Inventor: BADAR AMEY GANPAT
IPC: B60K35/00
Filed: 2019-10-15
Abstract: An automotive display module can include a mounting bracket, a display panel, a cover substrate, and a frame member. The mounting bracket can be securable to a component of an automobile. The display panel can be coupled to the mounting bracket and the frame member can be connected to a back side of the cover substrate.
Patent WO-2021076141-A1 (WO)
Title: Washout prevention element for expandable metal sealing elements
Inventor: FRIPP MICHAEL LINLEY
IPC: E21B33/126
Filed: 2019-10-17
Abstract: Methods for positioning an expandable metal sealing element in the wellbore. Am example method includes an expandable metal sealing element having a reactive metal and disposed in a location. The method further includes actuating a washout prevention element, contacting the expandable metal sealing element with a fluid that reacts with the reactive metal to produce a reaction product having a volume greater than the reactive metal, and allowing the washout prevention element to prevent at least a portion of the reaction product from flowing away from the location.
Patent WO-2020081898-A1 (WO)
Inventor: HOQUE MOHAMMAD O
IPC: C12Q1/686
Filed: 2019-10-18
Abstract: La présente invention concerne le domaine du cancer. Plus particulièrement, la présente invention porte sur des compositions et des procédés pour le dépistage du carcinome urothélial de la vessie. Dans un mode de réalisation, un procédé consiste à détecter CD24, CD49f et NANOG dans un échantillon d'urine chez un patient suspecté d'avoir un carcinome urothélial. Dans un mode de réalisation spécifique, l'étape de détection comprend une réaction en chaîne par polymérase (PCR). Dans certains modes de réalisation, l'étape de PCR utilise au moins une amorce comprenant les SEQ ID No : 1, 2, 23, 24, 13 et 14. Dans un autre mode de réalisation, le procédé comprend en outre le traitement du patient avec une ou plusieurs opérations de chirurgie, de radiothérapie, de chimiothérapie et d'immunothérapie.
Patent WO-2020263300-A1 (WO)
Title: Measuring quantum state purity
Inventor: KELLY JULIAN SHAW
IPC: G06N10/00
Filed: 2019-10-24
Abstract: Methods, systems and apparatus for measuring quantum state purity. In one aspect, a method for determining an average purity of multiple output quantum states, wherein the multiple output quantum states correspond to applications of respective random quantum circuits of a same circuit depth to a same initial quantum state, the method including: obtaining a plurality of data items, wherein each data item corresponds to a respective random quantum circuit of the same circuit depth and represents a probability that application of the respective random quantum circuit to the initial quantum state produces a respective measurement result; calculating a variance of a plurality of data items; determining a Porter-Thomas distribution having a dimension equal to a dimension of each output quantum state; and dividing the calculated variance by a variance of the Porter-Thomas distribution to determine the average purity.
Patent WO-2020101949-A1 (WO)
Title: Apparatus and methods for phase shifting
Inventor: DOMINO WILLIAM J
IPC: H01Q3/36
Filed: 2019-11-05
Abstract: Apparatus and methods for phase shifting are provided herein. In certain embodiments, a phase shifter includes a group of positive phase shifting circuits, a group of negative phase shifting circuits, and a group of selection switches for controlling selection of the positive phase shifting circuits and the negative phase shifting circuits. The selection switches are formed on a semiconductor die, and are operable to connect one or more selected positive phase shifting circuits and/or one or more selected negative phase shifting circuits between an input terminal and an output terminal, thereby controlling an overall phase shift provided by the phase shifter.
Patent WO-2020097170-A1 (WO)
Inventor: STOCKWELL BRENT R
IPC: C07D239/91
Filed: 2019-11-06
Abstract: The present disclosure provides,  inter alia , nanoparticle formulations comprising nanoparticles of a polymer loaded with a system x c 
 _  inhibitor, such as a nanoparticle formulation comprising nanoparticles of PEG-PLGA loaded with IKE or a pharmaceutically acceptable salt thereof. Methods of preparing such nanoparticle formulations, methods of treating cancers in a subject or selectively killing cancer cells using such nanoparticle formulations, and kits comprising such nanoparticle formulations are also provided.
Patent WO-2020097211-A1 (WO)
Inventor: COTE TIM
IPC: A61K8/49
Filed: 2019-11-06
Abstract: The disclosure provides topical compositions comprising pentoxifylline and methods of using the same.
Patent WO-2020102676-A1 (WO)
Inventor: BRIEVA THOMAS
IPC: C12N15/87
Filed: 2019-11-15
Abstract: Provided herein are improved methods of manufacturing cells, including T cells and CAR T cells. Also provided herein are methods of manufacturing cells, such as T cells and CAR T cells, obtainable from blood using a method incorporating membrane filtration and Ammonium-Chloride-Potassium (ACK) buffer to isolate the cells from other blood components.
Patent WO-2020117543-A1 (WO)
Title: Video frame brightness filter
Inventor: WOZNIAK MATTHEW RICHARD
IPC: G06T5/00
Filed: 2019-11-26
Abstract: A computing device (10) is provided, including a display (34) and a processor (14). The processor may, for each frame (42) of a plurality of frames included in a video (40), determine a brightness characterization (52) for a region of interest (46) of the frame. The processor may determine one or more additional brightness characterizations (52P, 52F) for the region of interest of one or more additional frames (42P, 42F) of the plurality of frames. The processor may determine that a high brightness condition (60) is present in the region of interest. The processor may generate a filter (58) for the frame based on the brightness characterization and the one or more additional brightness characterizations. The processor may apply the filter to the region of interest of the frame to generate a filtered frame (72). The high brightness condition is not present in the region of interest of the filtered frame. The processor may output the filtered frame for display at the display.
Patent WO-2020150383-A1 (WO)
Inventor: GAZERRO PETER
IPC: F21V21/00
Filed: 2020-01-15
Abstract: La présente invention concerne une armature qui comprend un support en L, un support en T et un ensemble de support de solive, ainsi que des procédés d'installation de l'armature qui éliminent le besoin d'installer une boîte de jonction électrique de service plus lourd et la difficulté d'enlèvement et de remise en place d'un câblage dans une nouvelle boîte de jonction électrique ou de fabriquer une structure de renforcement au niveau du chantier lors de la réalisation d'un rétromontage d'un ventilateur de plafond ou d'un appareil d'éclairage lourd. Les procédés d'installation et l'armature sont destinés à réduire le coût et la complexité de réalisation d'installations de rétromontage.
Patent WO-2020150587-A1 (WO)
Title: Laundry detergent compositions for eliminating, reducing, and/or inhibiting malodor
Inventor: CALDERON ALMA
IPC: C11D17/06
Filed: 2020-01-17
Abstract: A laundry detergent composition includes a detergent surfactant and saccharomyces ferment filtrate. The laundry detergent composition provides a benefit in the elimination, inhibition, and/or reduction of any malodor, for example dank malodor, body malodor, or food malodor.
Patent WO-2020185317-A1 (WO)
Inventor: SIMPSON LOGAN
IPC: B82Y10/00
Filed: 2020-01-29
Abstract: One embodiment is a method that includes generating drop pattern information. The method may comprise receiving pattern information. The pattern information may include one or both of: a substrate pattern of a representative substrate; and a template pattern of a representative template. The method may further comprise receiving offset information about a particular substrate that is representative of a measured state of the particular substrate relative to a reference state. The drop pattern information may represent a plurality of positions to place droplets of formable material on the particular substrate. The method may further comprise outputting the drop pattern information that is representative of the formable material that fills a volume between the template and the particular substrate that is in the measured state and the formable material does not spread into a border region at an edge of the particular substrate.
Patent WO-2020160107-A1 (WO)
Title: Vanne de compensation de température pour ressorts à gaz
Inventor: HERNDEN TYLER S
IPC: F16F9/34
Filed: 2020-01-29
Abstract: L'invention concerne un ensemble vanne de compensation de température, laquelle vanne comprend un ressort bimétallique qui se déforme d'une position fermée à une position ouverte en réponse à la température, et un corps de vanne monobloc ayant une ouverture à travers celui-ci et ayant une extrémité ouverte pour recevoir le ressort bimétallique. Le corps de vanne monobloc comprend des éléments de maintien intégrés pour maintenir le ressort bimétallique dans l'extrémité ouverte dans un emplacement tel que l'ouverture est bouchée par le ressort bimétallique quand elle est dans la position fermée et n'est pas bouchée par le ressort bimétallique quand elle est dans la position ouverte.
Patent WO-2020160305-A1 (WO)
Inventor: ZHAO XIN
IPC: H04N19/122
Filed: 2020-01-30
Abstract: L'invention concerne un procédé de décodage vidéo mis en œuvre dans un décodeur vidéo, ledit procédé consistant à recevoir un flux binaire vidéo codé comprenant une image actuelle. Le procédé consiste également à déterminer une taille de bloc d'un bloc actuel codé dans le mode de codage de sous-partitions intra (ISP). Le procédé consiste également à déterminer une direction et un nombre de partitions du bloc actuel d'après la taille de bloc déterminée. Le procédé consiste également à décoder le bloc actuel d'après la direction déterminée et le nombre de partitions du bloc actuel.
Patent WO-2020160366-A1 (WO)
Title: Adhésifs d'assemblage de produits comprenant des compositions d'agent poisseux faiblement volatil
Inventor: YUAN BING
IPC: C09J123/18
Filed: 2020-01-31
Abstract: L'invention concerne une composition d'agent poisseux comprenant au moins une résine d'hydrocarbure thermoplastique et une composition antioxydante ; une partie des composés organiques volatils dans la résine d'hydrocarbure thermoplastique ayant été éliminée ; la composition antioxydante comprenant au moins un antioxydant primaire et au moins un antioxydant secondaire ; et les niveaux de composé organique volatil individuel surveillés dans la composition d'agent poisseux étant inférieurs à environ 0,5 ppm tels que mesuré s par analyse de l'espace de tête GC/MS. L'invention concerne également des procédés de production de la composition d'agent poisseux ainsi que des adhésifs comprenant les compositions d'agent poisseux.
Patent WO-2020160470-A1 (WO)
Title: Method of using human spheroids for drug discovery
Inventor: CARROMEU CASSIANO
IPC: G01N33/50
Filed: 2020-01-31
Abstract: The present invention discloses, in one embodiment, a method of using human induced pluripotent stem cells to generate three-dimensional human organ tissue for therapeutic drug toxicity and discovery. In one embodiment, a high throughput microtiter plate is loaded with both wild type and Rett disease 3D spheroids and exposed to a drug library, and activity is measured and analyzed for disease rescue to wild type cell behavior.
Patent WO-2020167934-A1 (WO)
Title: Systèmes agricoles commandés et procédés de gestion de systèmes agricoles
Inventor: BONGARTZ TIMO
IPC: H04L29/06
Filed: 2020-02-12
Abstract: La présente invention concerne différentes techniques de commande d'un système agricole, comme par exemple un système agricole commandé, un appareil d'éclairage agricole et un procédé de gestion agricole. En outre, l'invention concerne un système agricole, qui comprend une pluralité de lignes de traitement de croissance de plantes d'un type de plante donné, une première ligne de traitement de la pluralité de lignes de traitement étant conçue pour déplacer une première pluralité de plantes à travers le système agricole le long d'un itinéraire ; et pour appliquer une première condition de croissance à la première pluralité de plantes de façon à satisfaire un premier paramètre d'agent actif pour la première pluralité de plantes.
Patent WO-2020167987-A1 (WO)
Inventor: WEI LILI
IPC: H04W92/12
Filed: 2020-02-12
Abstract: L'invention concerne une attribution de ressources à un réseau IAB (Integrated Access and Backhaul), une unité distribuée (DU) d'un IAB par exemple. Les procédés et les systèmes consistent à configurer une ou plusieurs ressources pour attribuer une disponibilité/utilisation de domaine temporel ou de domaine fréquentiel. Des configurations de ressources peuvent être alignées entre un ou plusieurs nœuds de sorte qu'une disponibilité de ressources d'un premier nœud peut être couplée à des ressources d'un second nœud. Les ressources attribuées peuvent comprendre des ressources de liaison montante, de liaison descendante, et des ressources flexibles. Des ressources attribuées peuvent être indiquées comme étant des types de ressources indisponibles, matérielles ou logicielles. Un motif de configuration peut indiquer une séquence de disponibilité de ressources de domaine temporel ou de ressources de domaine fréquentiel d'une DU dans le réseau IAB.
Patent WO-2020222892-A1 (WO)
Inventor: CADY ROGER
IPC: A61K39/00
Filed: 2020-02-18
Abstract: L'invention concerne des méthodes de soulagement immédiat de migraines ou de céphalées, comprenant l'administration d'un anticorps antagoniste anti-CGRP à un patient qui en a besoin. La présente invention concerne des méthodes de traitement de troubles de la céphalée, tels qu'une migraine, à l'aide d'anticorps et de fragments de ceux-ci (y compris des fragments Fab) qui se lient spécifiquement au peptide lié au gène de la calcitonine humaine (ci-après « CGRP »).
Patent WO-2020172334-A1 (WO)
Inventor: KIM YONG-CHUL
IPC: G06Q10/06
Filed: 2020-02-19
Abstract: L'invention concerne des systèmes et des procédés qui impliquent une application de retour, une application de traitement de retour, une application analytique et une application de modération d'événement. L'application de retour permet aux utilisateurs de soumettre un retour et affiche un retour reçu de manière anonyme à des destinataires de retour. L'application de traitement de retour anonymise le retour soumis et les données à extraire de l'application de traitement de retour et fournit le retour anonymisé et des données à l'application de retour. L'application de traitement de retour comprend une technologie pour protéger l'identité du donneur de retour et augmenter la vitesse d'anonymisation du retour et des données et fournir le retour anonymisé et des données à l'application de retour. L'application analytique examine le comportement d'envoi et de réception du retour de l'utilisateur et évalue son empathie et son authenticité de retour et son comportement d'apprentissage. L'application de modération d'événement peut contrôler l'application de retour et les données d'accès dans l'application de traitement de retour et l'application analytique.
Patent WO-2020185551-A1 (WO)
Title: Surprise assortment toy container with changeable configurations
Inventor: FALERNI JEFF
IPC: A63H13/16
Filed: 2020-03-06
Abstract: A collapsible and expandable toy container includes a base member configured for placement on a support surface, a sidewall extending upwards from the base member, a top member, and an interior space configured for holding one or more accessory items. A telescoping column supports the top member from the base member. The column is vertically extendible and retractable relative to the base member. At least one spring biases the column towards its extended position which raises the top member to access the interior space. Openable/closeable doors provides alternate access to the interior space. An optional intermediate platform may be arranged on the column between the top and base members. In the collapsed condition with doors closed, the container resembles a can and conceals any accessory items in the interior space. In the expanded condition, the container provides a multi-level play experience with play surfaces at different elevations for the child.
Patent WO-2021183120-A1 (WO)
Title: System and method for controlling a wind farm
Inventor: ROTBERT JAMES GREGORY
IPC: F03D7/02
Filed: 2020-03-11
Abstract: A system and method are provided for controlling a wind farm during low wind speeds. Accordingly, the farm controller designates at least one of the plurality of wind turbines of the wind farm as a designated turbine. The designated turbine is operating in a full auxiliary mode when the speed of the wind acting on the wind farm is below a wind speed threshold. The remaining wind turbines are operated in a reduced auxiliary mode. The reduced auxiliary mode includes the disabling of at least one of pitching and yawing of the remaining wind turbines. When a power output for the designated wind turbine exceeds a power threshold, the farm controller directs at least one group of the remaining wind turbines to transition from the reduced auxiliary mode to the full auxiliary mode. During certain grid conditions, the transition between auxiliary modes may be delayed.
Patent WO-2020191006-A1 (WO)
Title: Removable and convertible seat assembly
Inventor: EVANS CELYN
IPC: A61G1/06
Filed: 2020-03-18
Abstract: A removable and/or mountable seat assembly includes a seat back and a seat pan that are pivotally connected to each other via a locking device and rotate about at least one common axis of rotation. The locking device is in mechanical communication with the seat back and the seat pan and is configured to lock the seat back and the seat pan relative to each other about the at least one common axis of rotation. The locking device is configured to selectively lock the seat pan and the seat back such that the seat back and the seat pan lie along the common plane forming the stretcher or selectively lock the seat pan and the seat back such that the seat back and the seat pan form a seat. Additionally, the seat back and the seat pan may be locked in yet another position allowing for the easy transport and/or storage of the seat assembly.
Patent WO-2020206231-A1 (WO)
Inventor: GOODWIN TYLER
IPC: C12N5/0783
Filed: 2020-04-03
Abstract: The present disclosure provides methods for preparing a population of genetically- modified immune cells. The methods include contacting a population of immune cells with lipid nanoparticles in the presence of an apolipoprotein. The lipid nanoparticles include mRNA encoding an engineered nuclease having specificity for a recognition sequence in the genome of the immune cells. The mRNA is delivered into the immune cells and the engineered nuclease is expressed, generating a cleavage site at the recognition sequence. Further provided are populations of genetic ally-modified immune cells produced according to the disclosed methods, pharmaceutical compositions containing such cells, and methods of treating diseases with the genetically-modified immune cells.