baber/WOPTO huggingface dataset:
Patent AT-E239242-T1 (AT)
Inventor: PISCHEL JOCHEN
IPC: G05B19/418
Filed: 1999-01-13
Granted: 2003-05-15
Abstract: A method for allocating industrial or technical resources within technical systems, in particular to avert malfunctions, the system's operational state being represented by at least two parameter values, in such manner that as regards at least three different system operational states (Examples) at each of which at least one predetermined system function has been attained, the parameter value associated with the particular operational state is detected by detectors and is stored in a memory and in that, by means of pairwise comparison each time of two operational states and represented by the associated parameter values, a gauge is ascertained for the effect of the individual parameters on system function. The method of the invention allows quick and efficient resource allocation within technical systems, malfunctioning of such systems being reliably avoidable. Equipment of the invention operates on the principle of the method of the invention.
Patent AT-E274104-T1 (AT)
Inventor: KYTOENEN PAULI
IPC: D21G1/00
Filed: 1999-06-24
Granted: 2004-09-15
Abstract: A method and apparatus for calendering paper or board in the manufacture of coated grades of paper or board. At least one of the surfaces of an uncoated base material web is calendered, at least one layer of coating mix being applied onto said surface, and at least the coated surface of the base web is calendered again. The uncoated surface of the base web is calendered by means of a shoe calender having a nip length of at least 50 mm, and the coated surface of the base web is calendered by means of a calender having a nip length of 50 mm at the most.
Patent AT-E302632-T1 (AT)
Inventor: ORTH MICHAEL J
IPC: A61M25/08
Filed: 1999-06-29
Granted: 2005-09-15
Abstract: Methods, systems, and kits for subcutaneously implanting articles, such as drug inserts and reservoirs. The methods rely on percutaneously forming a tissue tract and radially dilating the tract to a diameter which permits introduction of the article. By fully expanding the lumenal diameter of the tissue tract prior to introduction of the article, damage to the article resulting from passage through a partially expanded tissue tract can be avoided. In the exemplary embodiment, a radially expandable sleeve is first percutaneously introduced to the subcutaneous target site. An assembly of a cannula and dilator is then passed through the sleeve, effecting radial expansion. The dilator is removed and the article is then introduced through a lumen of the cannula.
Patent AT-E254776-T1 (AT)
Inventor: ENGLEFIELD PAUL JONATHAN
IPC: G06F9/44
Filed: 1999-07-21
Granted: 2003-12-15
Abstract: A set of software components, a system and a method provide to a user of a data processing system per-value interpretative information relating to application data values. The method includes the following steps: in response to user selection of a set of an application component's data values, generating per-value interpretation information corresponding to the selected data values; and, in response to subsequent movement of an input device pointer into a display screen area associated with a data value within the set, presenting the interpretation information to the user via an output device connected to the data processing system. A processing component selectable by the user from set of processing components preferably responds to user selection of both the operation to be performed and a set of application data by performing the processing operation on the set of data to produce a result, and then generating per-value interpretation information corresponding to that result. The presentation of interpretation information to the user preferably uses a flyover text box in a GUI, as is known in the art for application-specific Bubble Help.
Patent AT-E256338-T1 (AT)
Inventor: BURKHARDT KLAUS
IPC: H01J3/02
Filed: 1999-06-01
Granted: 2003-12-15
Abstract: The invention is directed to an extremely low-capacitance device for shaping an electron beam. The device is based on a ceramic body having a monolithic multi-layer structure. The manufacture of the ceramic body ensues with the assistance of LTCC technology, whereby this method is designationally modified. The body is constructed of pre-sintered ceramic layers whose lateral shrinkage is suppressed. The through apertures of the electrodes for the electron beam are thus arranged exactly coaxially, and the tolerances of the electrode dimensions are decoupled from the shrinkage during sintering. The electron beam of an electron gun is focused and the intensity thereof is modulated with the assistance of such a device.
Patent AT-E276999-T1 (AT)
Inventor: BAIKER ALFONS
IPC: B01J23/755
Filed: 1999-07-13
Granted: 2004-10-15
Abstract: A single-stage process is described for the preparation of primary aliphatic polyamines of the formulain which R1 and R2 independently of one another are hydrogen, methyl, ethyl or aminomethyl, by reaction of polyalcohols on a Co/Ni catalyst with supercritical ammonia in the presence of hydrogen.
Patent AT-E279225-T1 (AT)
Inventor: RENNEBECK KLAUS
IPC: A61M1/36
Filed: 1999-07-26
Granted: 2004-10-15
Abstract: The invention relates to a bionic organ replacement which has a structure consisting of three groups of textile hollow microfibers. The hollow microfibers of each group run into in a liquid conductor which is central respectively. The hollow microfibers of the first group (1) are made from a proton-conducting material and have perforations (2) for draining bile into the area inside the fibers (1). One of the surfaces in essentially every hollow microfiber (1) of the first group (1) is hydrophilic and lipophilic whilst the other surface is hydrophobic and lipophobic. Cell cultures can be grown on the outer surfaces of all of the hollow microfibers.
Patent AT-E327460-T1 (AT)
Inventor: STAGGS WILLIAM A
IPC: F16K3/00
Filed: 1999-08-12
Granted: 2006-06-15
Abstract: An isolation gate valve (10, 10a, 10b, 124, 146, 210) is provided which has a valve body (12, 126, 212) presenting a passageway (14, 214) therethrough; a shiftable, apertured gate member (18, 224) is located within the body (12, 126, 212) and is shiftable between a valve open position permitting flow through the passageway (14, 214) and a valve closed position wherein the member (18, 224) is shifted into a flow-blocking relationship relative to the passageway (14, 214). A valve actuator (20, 130, 220) is provided which includes a gas-generating cartridge unit (22, 22a, 22b, 222) which, upon actuation, generates a charge of high pressure subsonic gas for shifting the gate member (18, 224) at a velocity of about 0.2 to about 0.33 in./msec. Preferably, the actuator includes a piston housing (56, 56a, 56b, 256) having a piston (72, 72a, 72b, 272) therein with a piston rod (71, 71a, 71b, 271) coupled between the piston (72, 72a, 72b, 272) and the gate member (18, 224). In the valve open position, the piston (72, 72a, 72b, 272) is adjacent the cartridge unit (22, 22a, 22b, 222) and is oriented so that the pressurized gas from the cartridge unit (22, 22a, 22b, 222) shifts the piston (72, 72a, 72b, 272) thereby closing the valve (10, 10a, 10b, 124, 146, 212). A dampener unit (99, 299) is provided in a association with the gate member (18, 224) to effect predetermined, controlled deceleration thereof as the gate member approaches its fully actuated position.
Patent AT-E369429-T1 (AT)
Inventor: WESTON JONATHAN
IPC: G01N33/569
Filed: 1999-05-06
Granted: 2007-08-15
Abstract: The present invention relates to the structural proteins of the causative agent of Pancreatic Disease in fish, nucleotide sequences encoding said proteins, vaccines comprising said proteins or nucleotide sequences and diagnostic kits comprising said proteins or nucleotide sequences.
Patent AT-E246958-T1 (AT)
Inventor: KUZEE HENDRIKA CORNELIA
IPC: C09C3/10
Filed: 1999-06-09
Granted: 2003-08-15
Abstract: Dispersions of pigment, such as calcium carbonate, titanium dioxide and types of clay, can be effectively stabilized by the use of carboxyl-containing fructan in an amount of 0.05-10% by weight, based on the dispersion, which fructan contains 0.5-3 carboxyl groups per mono-saccharide unit. The carboxyalkyl groups are in particular carboxymethyl groups, but the carboxyl groups can also be carboxyl groups obtained entirely or partially by oxidation. The carboxymethylfructan gives results which are comparable to or better than those obtained with the polyacrylates which are less desirable from the standpoint of health and environment.
Patent AT-E290501-T1 (AT)
Inventor: DANVILLE DAVID ROY
IPC: B65D75/36
Filed: 1999-10-20
Granted: 2005-03-15
Abstract: The package is designed to require a sequence of opening steps too complex for a child to perform, but simple enough for an adult to perform. The package is formed from a top having a surface that projects from one face of the top sheet and forms a recess in the opposite face of the top sheet, a bottom sheet overlying the opposite face of the top sheet, arranged to enclose the recess, a sealed portion and an unsealed portion formed between the top sheet and the bottom sheet, wherein each recess is associated with a sealed portion and an unsealed portion, and a tear slit located between the unsealed portion and an edge of the package, wherein the tear slit does not contact any edge of the package.
Patent AT-E260967-T1 (AT)
Inventor: WERNICKE TODD MICHAEL
IPC: D06L1/20
Filed: 1999-10-22
Granted: 2004-03-15
Abstract: A product and process for laundering delicate or dry-clean only garments in a conventional home washing machine. The process represents a home version of the commercial wet-cleaning processes for cleaning of delicate garments. The product comprises a liquid combination washing/conditioning composition and optionally a wash pretreatment composition, a flexible wrap container within which the garments are contained during washing and a pretreatment applicator.
Patent AT-E275237-T1 (AT)
Inventor: MULLINS ALBERT AUGUSTUS
IPC: E21B21/10
Filed: 1999-11-12
Granted: 2004-09-15
Abstract: A casing or tubular fill and circulator assembly is indicated, wherein a singular valve is used for filling and circulating the casing as well as providing for pressure equalization when the singular valve is in the open position. The valve is constructed so that it is opened upon being inserted into the upper end of the casing. For filling the casing, only the valve is inserted into the upper end of the casing whereupon the valve is fully opened so that fluid can be pumped into the casing without a pressure drop or erosion of any of the valve members. For circulation, the apparatus is advanced further into the casing until a cup seal closes off the top of the casing. Once flow is initiated in that condition, internal pressure in the casing, at very low applied pressures, will begin the circulation through the casing. With the valve in the fully open position, erosive effects from flow are eliminated during filling and circulation. Additionally, with the cup seal in the casing and the valve fully open, the pumps can be stopped and pressure equalization will occur through the fully opened valve without restriction or delay.
Patent DE-14760712-T1 (DE)
Title: Pyridopyrimidin- oder Pyrimidopyrimidlnverbindung, Herstellungsverfahren, PharmazeutischeZusammensetzung und Verwendung davon
Inventor: SHEN JINGKANG
IPC: C07D519/00
Filed: 2014-02-28
Abstract: Pyridopyrimidin- oder Pyrimidopyrimidinverbindung, welche durch Formel (Ia) dargestellt ist, deren Isomer, pharmazeutisch annehmbares Salz, Ester, Prodrug oder Solvat:wobei R1 und R2 jeweils unabhängig 3-Oxa-8-azabicyclo[3.2.1]octanyl, 8-Oxa-3-azabicyclo[3.2.1]octanyl oder NRARB sind, und mindestens einer von R1 und R2 3-Oxa-8-azabicyclo[3.2.1]octanyl oder 8-Oxa-3-azabicyclo[3.2.1]octanyl ist; wobei, RA und RB jeweils unabhängig H, C1-C6-Alkyl, das unsubstituiert oder mit C1-C6-Alkoxy oder Halogen substituiert ist, oder C1-C6-Alkoxy, das unsubstituiert oder mit Halogen substituiert ist, sind, oder RA und RB, gemeinsam mit dem N, an welches sie gebunden sind, einen stickstoffhaltigen gesättigten heterocyclischen Ring mit 4 bis 8 Ringatomen bilden, welcher unsubstituiert oder mit C1-C6-Alkyl, C1-C6-Alkoxy oder Halogen substituiert ist, wobei der stickstoffhaltige gesättigte heterocyclische Ring ein Piperidinring, Morpholinring, Piperazinring, N-Methylpiperazinring, Homomorpholinring oder Homopiperazinring ist; und R3 Phenyl oder Pyridyl, das unsubstituiert oder mit 1 bis 5 Substituenten substituiert ist, wobei der Substituent Halogen; Hydroxyl; Cyano, C1-C7-Alkyl, das unsubstituiert oder mit C1-C7-Alkoxy, Halogen oder Hydroxy substituiert ist; C1-C7-Alkoxy; -NHS(=O)2C1-C7-Alkyl; -NH2; C5-C6-Arylamino; C1-C7-Alkylamino; Di(C1-C7-alkyl)amino; -C(O)NH2; oder -C(O)NHC1-C3-Alkyl ist.
Patent DE-16842407-T1 (DE)
Title: Verfahren zur reinigung einer flüssigkeit
Inventor: SHMIDT JOSEPH LVOVICH
IPC: B01D61/00
Filed: 2016-07-21
Abstract: Flüssigkeitsreinigungssystem, umfassend eine Rohflüssigkeitszufuhrleitung mit einem darauf montierten Rohflüssigkeitszufuhrventil, das mit einer Filtrationseinheit verbunden ist, die ein Flüssigkeitsreinigungsmittel mit einem Einlass für Rohflüssigkeit und Auslässen für gereinigte Flüssigkeit und Ablaufflüssigkeit, eine Flüssigkeitsmischvorrichtung, ein Druckaufrechterhaltungsmittel, eine Leitung zum Zuführen einer Mischung aus Rohflüssigkeit und dem im Flüssigkeitsreinigungsprozess in dem Flüssigkeitsreinigungsmittel gebildeten Konzentrat, eine Kreislaufleitung, eine Gereinigtflüssigkeitsleitung, eine Ablaufflüssigkeitsleitung und eine mit dem Druckaufrechterhaltungsmittel und einem Druckänderungsüberwachungsmittel gekoppelte Steuereinheit sowie das Rohflüssigkeitszufuhrventil beinhaltet, dadurch gekennzeichnet, dass die Filtrationseinheit angepasst ist, um den Druck in dem Flüssigkeitsreinigungsmittel mit periodischer Entleerung der Flüssigkeitsströmung mit einer Ablaufflüssigkeitsgeschwindigkeit, die die Leistung der in der Rohflüssigkeitszufuhrleitung stromaufwärts des Flüssigkeitsmischvorrichtung angeordneten Druckaufrechterhaltungsmittels übersteigt, in Form eines mit der Leitung zum Mischen der Rohflüssigkeit und des im Filtrationsprozess gebildeten Konzentrats verbundenen Drucktanks zu stabilisieren, und gleichzeitig die Menge der konzentrierten Flüssigkeit in der Flüssigkeitsmischvorrichtung durch die Kopplung der Steuereinheit mit dem Druckaufrechterhaltungsmittel in der Flüssigkeitsmischvorrichtung in Form eines Drucktanks und mit einem Flüssigkeitskreislaufströmung-Aufrechterhaltungsmittel, das in der Rohflüssigkeits-/Konzentratzufuhrleitung stromaufwärts des Flüssigkeitsreinigungsmittels angeordnet ist, einzustellen, und mit einem in der Ablaufflüssigkeitsleitung angeordneten Ablaufauslassventil.
Patent DE-22199371-T1 (DE)
Title: Verfahren zur beurteilung des risikos der entwicklung einer viruserkrankung unter verwendung eines genetischen tests
Inventor: HATCHWELL ELI
IPC: C12Q1/6883
Filed: 2019-08-08
Abstract: Immunsuppressives Medikament zur Verwendung bei der Behandlung eines Leidens bei einem Subjekt, das einer Therapie mit einem immunsuppressiven Medikament bedarf,wobei ein verringerte Risiko einer progressiven multifokalen Leukoenzephalopathie (PML) bei dem Subjekt auf eine Infektion des Gehirns durch das John-Cunningham-Virus (JCV) zurückzuführen ist,wobei das verringerte Risiko des Subjekts auf das Fehlen einer genomischen Variation ausgewählt aus der Gruppe bestehend aus Folgendem zurückzuführen ist: chr9:137779251, G>A und chr1:160769595, AG>A,wobei die Chromosomenposition der genomischen Variation in Bezug auf UCSC hg19 definiert ist.
Patent DE-570027-T1 (DE)
Inventor: DAVIS MARK M
IPC: C07K16/00
Filed: 1985-02-28
Abstract: The invention includes an isolated polypeptide which comprises an amino acid sequence unique to an  alpha -subunit of a T-cell antigen receptor and antibodies which bind thereto. The polypeptide and antibodies thereto may be used as a therapeutic agent or as a diagnostic agent. <IMAGE>   <IMAGE>
Patent ES-2201947-T1 (ES)
Title: Dispositivo de arrastre de puerta de garaje o similar.
Inventor: DUPIELET NORBERT
IPC: E05F15/16
Filed: 2001-11-27
Abstract: Dispositivo de arrastre de puerta de garaje o similar, guiada en su movimiento con medios de guiado, que comprende un motor (4; 39; 48; 64) y una conexión mecánica entre el motor y la puerta, caracterizado porque la conexión mecánica está constituida por un brazo extensible (5; 37; 43a, 43b...; 60a, 60b...).
Patent ES-2118672-T1 (ES)
Title: Detector de presion absoluta de tipo capacitivo y su metodo de formacion.
Inventor: KO WEN H
IPC: G01L7/08
Filed: 1995-11-09
Abstract: UN SENSOR CAPACITIVO DE PRESION ABSOLUTA (10) INCLUYE UN SUSTRATO (14) QUE TIENE UN ELECTRODO (24) DEPOSITADO SOBRE EL MISMO Y UN DIAFRAGMA (12) DISPUESTO SOBRE EL SUSTRATO (14). A MEDIDA QUE AUMENTA LA PRESION, EL DIAFRAGMA (16) SE DOBLA, TOCA EL ELECTRODO (24) (EN EL MODO DE CONTACTO) Y CAMBIA LA CAPACITANCIA DEL SENSOR (10). SE DETECTA EL CAMBIO DE CAPACITANCIA Y CON ELLO LOS CAMBIOS DE PRESION. SE UTILIZA UNA CONDUCCION ENTERRADA PARA DETECTAR EL CAMBIO DE LA CAPACITANCIA EN UN ELEMENTO (34) POR DEBAJO DEL DIAFRAGMA (16) Y DETERMINAR DE ESTA FORMA LA PRESION DETECTADA. SE MANTIENE UN VACIO EN LA CAMARA (34) MEDIANTE LA SELECCION APROPIADA DEL GROSOR DE UN ELECTRODO DE DETECCION Y DE UNA CAPA DE AISLAMIENTO (32), MEDIANTE LA EXPOSICION DE LOS MISMOS A UN CICLO TERMICO Y MEDIANTE LA UNION HERMETICA DEL CONJUNTO DE DIAFRAGMA (12) CON EL SUSTRATO (14).
Patent ES-2116249-T1 (ES)
Title: Envolvente de embalaje cerrado por unos papillotes y procedimiento de embalaje.
Inventor: DAELMANS EDDY
IPC: B65D65/14
Filed: 1996-10-08
Abstract: ENVOLTURA DE EMBALAJE CONSTITUIDA POR UNA PELICULA (10, 40) DESTINADA A CERRARSE MEDIANTE DOS RULOS (18) SITUADOS A UNO Y OTRO LADO DE UN ARTICULO A EMBALAR (12) Y QUE COMPRENDE, POR EL LADO INTERIOR CON RESPECTO AL ARTICULO A EMBALAR (12), UNA CAPA DE SELLADO DISPUESTA EN DOS BANDAS TRANSVERSALES (20A, 20B) Y (46A, 46B) A UNO Y OTRO LADO DEL ARTICULO A EMBALAR (12) Y QUE SE EXTIENDEN PARALELAMENTE A UN EJE QUE PASA POR LOS DOS RULOS (18). EL PROCEDIMIENTO DE EMBALAJE CONSISTE EN SELLAR EL EMBALAJE A LA ALTURA DE LAS BANDAS TRANSVERSALES.
Patent ES-2098214-T1 (ES)
Title: Circuito de control de refrigerante altamente latente para sistema de aire acondicionado.
Inventor: BUSSJAGER RUDDY C
IPC: F25B29/00
Filed: 1996-08-23
Abstract: UN MONTAJE DE CONTROL DE UN REFRIGERANTE ALTAMENTE LATENTE PARA UN SISTEMA DE AIRE ACONDICIONADO POR EXPANSION-COMPRESION UTILIZA UNA BOBINA SUBREFRIGERADORA (44) COLOCADA EN EL LADO DE LA SALIDA DEL AIRE DE LA BOBINA EVAPORADORA DEL AIRE INTERIOR (22). UNA RAMA DEL CONDUCTO DEL LIQUIDO (42) SUMINISTRA UN REFRIGERANTE LIQUIDO CONDENSADO DESDE EL CONDENSADOR (16) HASTA LA BOBINA SUBREFRIGERADORA (44), Y UN LIMITADOR DE CORRIENTE, QUE PUEDE SER UN TXV, DISMINUYE LA PRESION DEL LIQUIDO SUBREFRIGERADO ANTES DE QUE EL REFRIGERANTE ALCANCE EL DISPOSITIVO DE EXPANSION (20) ASOCIADO CON LA BOBINA EVAPORADORA (22). UN TUBO DE DERIVACION (50) CONECTA EL CONDENSADOR (16) CON EL DISPOSITIVO DE EXPANSION (20), Y TIENE UNA VALVULA ACCIONADA POR UN SOLENOIDE DE UN TUBO DE UN LIQUIDO (32) QUE ES ACCIONADA POR UN HUMIDISTATO. CUANDO SE REQUIERE UNA DESHUMIDIFACION, EL SOLENOIDE ES CERRADO Y EL REFRIGERANTE FLUYE A TRAVES DE BOBINA SUBREFRIFGERADORA (44). CUANDO SE SATISFACE EL HUMIDISTATO, EL SOLENOIDE SE ABRE Y EL RECORRIDO DEL REFRIGERANTE DERIVA LA BOBINA SUBREFRIGERADORA (44). EL MONTAJE SUBREFRIGERADOR ALTAMENTE LATENTE (40) PUEDE SER MONTADO O ACTUALIZADO EN UN APARATO DE AIRE ACONDICIONADO EXISTENTE.
Patent ES-2129385-T1 (ES)
Title: Unidad de accionamiento para aparato elevador.
Inventor: FISCHER HUBERT
IPC: B66B11/08
Filed: 1998-06-03
Abstract: LA INVENCION SE REFIERE A UNA UNIDAD MOTRIZ PARA UN EQUIPO ELEVADOR, ESPECIALMENTE UN ASCENSOR, QUE CONSTA DE UN MOTOR (6), UN ENGRANAJE (2), UNA INSTALACION DE FRENADO (4) Y UNA CARCASA (8). LA UNIDAD SE CARACTERIZA POR LLEVAR JUNTOS EN LA CARCASA (8) EL MOTOR (6) Y LA INSTALACION DE FRENADO. ADEMAS, EN LA CARCASA (8) PUEDE ESTAR INSTALADA AL MENOS UNA PARTE DEL ENGRANAJE (2) EN CALIDAD DE ENGRANAJE AUXILIAR O INCORPORADO, DE MANERA QUE LA CARCASA (8) CONSTITUYE TAMBIEN EN GRAN MEDIDA LA CAJA DEL ENGRANAJE.
Patent CY-1108255-T1 (CY)
Title: Μεθοδος για τη συνθεση μιας ενωσης βενζιμιδαζολης
Inventor: GUSTAVSSON ANDERS
IPC: C07D401/12
Filed: 2008-08-12
Abstract: Μια διαδικασία για την παρασκευή ομεπραζόλης ή εσωμεπραζόλης από πυρμεθυλ αλκοόλη μέσω χλωριούχου πυρμεθυλ και πυρματαζόλης που χαρακτηρίζεται από το ότι ολόκληρη η αλληλουχία αντίδρασης εκτελείται χωρίς κάποια απομόνωση ή καθαρισμό των ενδιάμεσων. Περαιτέρω, η αντίδραση εκτελείται σ’ ένα σύστημα διαλύτη κοινό για ολόκληρη την αλληλουχία αντίδρασης και αδρανή στα αντιδραστήρια που χρησιμοποιούνται στη διάρκεια της διαδικασίας και περιλαμβάνει έναν οργανικό διαλύτη μη αναμίξιμο με νερό και μία καθορισμένη ποσότητα νερού.
Patent CY-1109296-T1 (CY)
Title: Ανυδρο κρυσταλλικο παραγωγο της ημιθειικης αζιδο κυτοσινης
Inventor: CONNOLLY TERRENCE JOSEPH
IPC: A61K31/70
Filed: 2009-07-24
Abstract: Η παρούσα εφεύρεση σχετίζεται με το ημιθειικό άλας της 1-[4(S)-αξιδο-2(S),3(R)-διυδροξυ-4-(υδροξυμεθυλο)-1(R)-κυκλοπεντυλο]κυτοσίνης (Ιa) με βελτιωμένη σταθερότητα και φυσικές ιδιότητες που διευκολύνουν την παρασκευή, το χειρισμό και τη μορφοποίηση της ένωσης του τύπου Ι και των πολυμορφικών κρυσταλλικών μορφών αυτής.
Patent CY-1115605-T1 (CY)
Title: Ενωσεις για την αναστολη του ενζυμου πρωτεασωματος
Inventor: SMYTH MARK S
IPC: C07K5/062
Filed: 2014-10-07
Abstract: Ενώσεις που βασίζονται σε πεπτίδια, οι οποίες περιλαμβάνουν τριμελείς δακτυλίους που περιέχουν ετεροάτομα, αναστέλλουν αποτελεσματικά και εκλεκτικά τις ειδικές δραστικότητες των Ν-τερματικών πυρηνόφιλων (Ntn) υδρολασών. Οι δραστικότητες εκείνων των Ntn που έχουν πολλαπλές δραστικότητες μπορούν να αναστέλλονται διαφορικά από τις ενώσεις που περιγράφονται. Παραδείγματος χάριν, η όμοια με χυμοθρυψίνη δραστικότητα του πρωτεασώματος 20S μπορεί να αναστέλλεται εκλεκτικά με τις ενώσεις της εφεύρεσης. Οι ενώσεις που βασίζονται σε πεπτίδια περιλαμβάνουν ένα εποξείδιο ή αζιριδίνη και επεξεργασία με χαρακτηριστική ένωση στο Ν-τέρμα. Μεταξύ άλλων θεραπευτικών χρησιμοτήτων, οι ενώσεις που βασίζονται σε πεπτίδια αναμένεται να επιδεικνύουν αντιφλεγμονώδεις ιδιότητες και αναστολή του κυτταρικού πολλαπλασιασμού.
Patent CY-1117254-T1 (CY)
Title: Μεθοδοι τροποποιησης ευκαρυωτικων κυτταρων
Inventor: MURPHY ANDREW J
IPC: C12P21/06
Filed: 2015-12-22
Abstract: Μέθοδος τεχνητής επαγωγής και αξιοποίησης ευμεγεθών φορέων DNA οι οποίοι, μέσω ομόλογου ανασυνδυασμού, στοχεύουν και τροποποιούν, κατ' οποιονδήποτε επιθυμητό τρόπο, ενδογενή γονίδια και χρωμοσωμικούς τόπους ευκαρυωτικών κυττάρων. Αυτοί οι ευμεγέθεις φορείς DNA που στοχεύουν ευκαρυωτικά κύτταρα, αποκαλούμενοι LTVEC, προέρχονται από θραύσματα κλωνοποιημένου γενωμικού DNA που είναι πιο ευμεγέθη από εκείνα που χρησιμοποιούνται τυπικά σε άλλες προσεγγίσεις ομόλογης στόχευσης ευκαρυωτικών κυττάρων. Επίσης παρέχεται μία ταχεία και ευχερής μέθοδος ανίχνευσης των ευκαρυωτικών κυττάρων στα οποία ο LTVEC έχει στοχεύσει και τροποποιήσει το επιθυμητό ενδογενές γονίδιο ή γονίδια ή χρωμοσωμικό τόπο ή τόπους ορθώς, καθώς επίσης παρέχεται και η χρήση αυτών των κυττάρων προς παραγωγή οργανισμών που φέρουν τη γενετική τροποποίηση.
Patent CY-1117986-T1 (CY)
Title: Ενωσεις αρυλ- ή ετεροαρυλ-υποκατεστημενου βενζολιου
Inventor: KUNTZ KEVIN WAYNE
IPC: C07D491/08
Filed: 2016-09-07
Abstract: Η παρούσα εφεύρεση αφορά ενώσεις αρυλ- ή ετεροαρυλ -υποκατεστημένου βενζολίου. Η παρούσα εφεύρεση αφορά επίσης φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις και μεθόδους θεραπευτικής αγωγής καρκίνου μέσω χορήγησης αυτών των ενώσεων και φαρμακευτικών συνθέσεων σε υποκείμενα που τις χρειάζονται. Η παρούσα εφεύρεση αφορά επίσης τη χρήση τέτοιων ενώσεων για ερευνητικούς ή άλλους μη θεραπευτικούς σκοπούς.