Patent SG-11201803994V-A (SG)
Title: Microfluidic particle manipulation
Inventor: AI YE
IPC: H03H9/145
Filed: 2016-11-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau r5)1 (43) International Publication Date .... .....r ....) 18 May 2017 (18.05.2017) WIPO I PCT ID Hit (10) WO International 2017/082828 111111111111111111IIIIII1111111111111111111111111111111111111MIIIIIII0IIIIII Publication Al Number (51) International Patent Classification: AO, HO3H 9/145 (2006.01) G01N 29/02 (2006.01) BZ, (21) International Application Number: HN, PCT/SG2016/050560 KW, (22) International Filing Date: MG, 11 November 2016 (11.11.2016) OM, (25) Filing Language: English TN, (26) Publication Language: English ZW. (30) Priority Data: (84) Designated 10201509280Y 11 November 2015 (11.11.2015) SG kind (71) Applicant: SINGAPORE UNIVERSITY OF TECHNO- TZ, LOGY AND DESIGN [SG/SG]; 8 Somapah Road, #05- TJ, 302 Building 3, Level 5, Singapore 487372 (SG). DK, (72) Inventors: AI, Ye; 53 Changi South Avenue 1, #10-10, LV, Singapore 485996 (SG). COLLINS, David John; c/o SM, Singapore University of Technology and Design, 8 GW, KM, ML, MR, NE, SN, TD, TG). Somapah Road, #05-302 Building 3, Level 5, Singapore Declarations 487372 (SG). DO, SC, GM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, States (unless otherwise indicated, for every of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, under Rule 4.17: of inventorship (Rule 4.17(iv)) (74) Agent: AMICA LAW LLC; 30 Raffles Place, #14-01 Published: Chevron House, Singapore 048622 (SG). — with international search report (Art 21(3)) Designated States indicated, (81) (unless otherwise for every kind of national available): AE, AG, AL, AM, protection (54) Title: MICROFLUIDIC PARTICLE MANIPULATION (57) : The present invention relates to the for use of acoustic waves the manipulation and 35 40 sorting of and cells. In an embodiment, particles there is provided a microfluidic device for manipu- 25 35 30n 45 lating in fluid device a particle a suspension, the comprising: (a) a substrate; (b) a channel defined in the substrate, the channel having an inlet for re- ceiving the fluid suspension and an outlet for dis- charging the fluid suspension; and (c) an acoustic A source configured to deliver a travelling surface n 1 / 4 k\‘ acoustic wave ' Ms sheat ' transverse the flow of the fluid sus - - v v .., w, pension in the channel, wherein the acoustic source area 4 , \ fi etz , ,, , ,V„‘ . is interdigital IDT an transducer (IDT), the com- k tlet z t k .4, having prises a plurality of concentric circular arcs a tapered end directed at the channel, and the %, 1/4%1 , fl, , i n a s be t ween l. t tapered r e d m end ?ri aperture alternative 4* a l device mand eembodiment, of a l an t e r na the 4 11 15 comprises a second channel disposed intermediate .4t the first channel and the acoustic source wherein the first and second channels are connected by a GC 50 20 50 10 pumping channel. N GC N GC Figure 1 C ---.... IN li C N O