Patent SG-11201811152Y-A (SG)
Title: Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
Inventor: GÖRGENS ANDRÉ
IPC: A61K39/395
Filed: 2017-07-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H1110111111111111111101111101001111110111H1111111111110111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/015539 Al 25 January 2018 (25.01.2018) WI P0 I P C T (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 39/395 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (21) International Application Number: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, PCT/EP2017/068486 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 21 July 2017 (21.07.2017) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1612643.5 21 July 2016 (21.07.2016) GB UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: EVOX THERAPEUTICS LTD [GB/GB]; EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 2nd Floor, King Charles Hosue, Park End Street, Oxford MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Oxfordshire OX1 1JD (GB). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: GORGENS, Andre; Domarvagen 18, KM, ML, MR, NE, SN, TD, TG). SE-14162 Huddinge (SE). GUPTA, Dhanu; Myrstuguva- gen 147, Varby, Huddinge, 143 32 Stockholm (SE). WIK- Published: _ LANDER, Oscar; Greta Garbos vag 21B, Solna, 16940 — with international search report (Art. 21(3)) Sweden (SE). — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of = (74) Agent: COOLEY (UK) LLP; Dashwood, 69 Old Broad amendments (Rule 48.2(h)) Street, London Greater London EC2M 1QS (GB). — with sequence listing part of description (Rule 5.2(a)) = (81) Designated States (unless otherwise indicated, for every = kind of national protection available): AE, AG, AL, AM, = = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = (54) Title: USES OF EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY (57) : The present invention pertains to engineered extracel- = _ lular vesicles(EVs) for use in a variety of research, diagnostic, imag- Fc binder domain ing and therapeutic applications. The EVs are engineered to enable in- corporation and surface display of various proteins of interest, which = = — Exosomal protein may be exogenous and/or endogenous in nature. The coating of EVs is achieved through inventive protein engineering of EV polypeptides, and the present invention thus relates to methods for coating of EVs, EVs per se, as well kits, detection methods, diagnostic applications, • „„\‘ imaging and delivery methods based on said engineered EVs. — = _ _ = = `, i f — = = \ / / \ \ _ \ \ ,,,z Lipid bilayer 1-1 \ .4 Lumen 01 en ir) ir) Extracellular vesicle Il 0 _.... ,—, c:::, Figure 1 ei 0