baber/WOPTO huggingface dataset:
Patent EC-SP12011643-A (EC)
Title: Formulación subcutánea de anticuerpo anti-her2
Inventor: MAHLER HANNS-CHRISTIAN
IPC: A61K9/00
Filed: 2012-01-31
Abstract: La presente invención está relacionada con una formulación farmacéutica altamente concentrada y estable de un anticuerpo anti-HER2 farmacéuticamente activo, como por ejemplo el Trastuzumab (HERCEPIN), Pertuzumab o T-DM1, o una mezcla de tales moléculas de anticuerpo para la inyección subcutánea. En particular, la presente invención está relacionada con formulaciones que comprenden, además de una cantidad adecuada del anticuerpo anti-HER2, una cantidad efectiva de al menos una enzima hialuronidasa como una formulación combinada o para su utilización en forma de una co-formulación. Dichas formulaciones comprenden adicionalmente al menos un agente tamponante, como por ejemplo un tampón histidina, un estabilizante o una mezcla de dos o más estabilizantes (por ejemplo un sacárido, como por ejemplo la ?,?-trehalosa dihidratada o la sacarosa, y opcionalmente metionina como segundo estabilizante), un tensioactivo no iónico y una cantidad efectiva de al menos una enzima hialuronidasa. También se proporcionan los métodos para preparar tales formulaciones y la utilización de las mismas.
Patent GB-189606751-A (GB)
Title: Improvements in or appertaining to Carbons for Electrical Purposes.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1896-03-27
Granted: 1897-01-30
Abstract: 6751. Thompson, W. P., [Lessing, A.]. March 27. Drawings to Specification. Tapping holes in carbon. Carbons for electrical purposes are prepared to receive screw terminals by making screw-threads in them before heating, by means of a tap large enough to allow for the shrinkage in heating.
Patent GB-189701228-A (GB)
Title: Process for the Decoration of China, Earthenware, Glass, Papiermache, Iron, Tin, Leather, Wood, Japanned, and other Goods.
Inventor: RATAUD PAUL
Filed: 1897-01-16
Granted: 1897-11-20
Abstract: 1228. Rataud, P. Jan. 16. Transfers.-In the process of decorating china, earthenware, glass, papier mÔchÚ, iron, tin, leather, wood, and japanned and other goods, transfers of a special kind are employed. These transfers are printed in ink or colour mixed with varnish made of boiled linseed oil, boiled beef suet, ceramic colours, and flux, by blocks or plates of copper, zinc, wood, or other substance, prepared by means of photochromy, heliochromy, lithography, electrotypy, or grained paper transfers. The paper used for making the transfers is a good tissue paper or duplex transfer paper. The tissue paper is coated with flour or starch paste or the like, and when dry is rolled by a calendering-machine ; the paper is next coated with dextrin or best gum arabic, or the like, and is again calendered when dry. The paper, thus prepared, is printed upon, the darkest colours being first applied. If desired, the printing may be done in boiled linseed oil, upon which the colours are afterwards dusted. The printed design is coated with a varnish by means of a stencil. For the decoration of wood, leather, or other goods that do not require to be fired, best printing-inks are used, instead of ceramic colours, for the transfers. In applying the transfers to the china &c. articles, these are either heated or sized with a varnish.
Patent GB-189702393-A (GB)
Title: A New and Improved System of Assurance.
Inventor: DAVIES HENRY
Filed: 1897-01-29
Granted: 1897-12-04
Abstract: 2393. Davies, H. Jan. 29. Insurance.-In order to diminish the risk of non-payment on the part of debtors, or of non- fulfilment of contracts, a policy of insurance is taken out by debtors, creditors, or contractors, for the whole, or part, of the debts or other liabilities.
Patent GB-189716952-A (GB)
Title: Improvements in Methods of Preventing the Bursting of Bottles and other Receptacles while Substances Enclosed therein are being Sterilised, and in Apparatus therefor.
Inventor: ROCKSTROM AXEL LEONARD
Filed: 1897-07-17
Granted: 1897-09-11
Abstract: 16,952. Rockstr÷m, A. L. July 17. Liquids, sterilizing.-Relates to a process and apparatus for preventing the bursting of bottles &c. containing beer or other liquid while their contents are being sterilized. This object is effected by regulating the external pressure on the bottles to equal the internal pressure. The bottles are sterilized in the chamber D, which is connected by pipes Q, e<1> to a smaller chamber E<1> above, connected by the pipe c' to the pressure regulator S, A. The regulator comprises a vessel A, of a material having the same coefficient of expansion as the bottles, encased in the chamber D, and connected through the valve chamber S and pipe d<1> with a reservoir of compressed gas. The vessel A is filled with the same liquid as that to be sterilized. The spindle of the valves in the chamber S is connected to a flexible diaphragm, and during the sterilizing process the valves are automatically opened or closed by the increase or decrease of pressure in the vessel A, the admission of the compressed gas through the pipes d<1>, c', chamber E<1>, and pipes Q, e' to the chamber, or the escape of the gas during cooling, being thus automatically regulated. The admission of the gas to the chamber D may also be controlled by hand, in which case the pressure regulator is dispensed with.
Patent GB-189719331-A (GB)
Title: Improvements in the Driving Gear of Cycles.
Inventor: WYLIE JOHN
Filed: 1897-08-21
Granted: 1898-07-09
Abstract: 19,331. Wylie, J., and O'Neill, H. Aug.21. Driving-mechanism for bicycles, tricycles, &c., consisting of epicyclic gearing arranged to cause the chain-wheels to be driven at twice the speed of the cranks. Each crank H works in conjunction with a chain-wheel D, which is geared by a chain to a pinion on the driving-wheel or axle. A spindle A is fixed in the frame B, C, and on it are loosely mounted chain - wheels D, bevel pinions E, and blocks F carrying bevel pinions K. The pinions E are fixed to, or combined with, the chain-wheels D, and they gear with the pinions K and also with stationary pinions G fixed to the spindle A. The blocks F are connected by arms J to the cranks H, or the cranks H may be dispensed with and the pedals fixed to the arms J. When the cranks are rotated, the chain-wheels Dare caused to rotate at twice the rate of the cranks through the action of the epicyclic gearing.
Patent GB-189722648-A (GB)
Title: Improvements in and connected with Apparatus for the Generation and Combustion of Acetylene Gas.
Inventor: AGERON JULES ALBERT
Filed: 1897-10-02
Granted: 1898-10-01
Abstract: 22,648. Ageron, J. A., and Wirth, L. P. Oct. 2. Regulator.- Relates to the combustion of acetylene gas in an oxidizing atmosphere. The application to street lamps is described, in which cylinders containing the gases are placed in the base of the lamp. A pressure regulator, Fig. 16, is placed above each cylinder and on the gas outlet tube, and consists of a bellows 48, the upper end of which is fixed and the lower end attached to one end of a lever 49. The lever 49 is keyed upon the cock 50 which controls the passage of the gas into the bellows, from whence it passes to the burners.
Patent GB-189723517-A (GB)
Title: Utensil for Making Tea or coffee in the Cup.
Inventor: STEPHENS ALBERT FRANKLIN
Filed: 1897-10-13
Granted: 1897-11-13
Abstract: 23,517. Stephens, A. F., and Connell, R. T. Oct. 13. Tea &c. making apparatus.-A receptacle of fine wire gauze 10, for containing sufficient tea or coffee for one cup, is held between the bottom and cover of a perforated bowl 1 which is provided with a handle 3. Boiling water is poured into the cup containing the appliance, and, when the tea or coffee has been sufficiently infused, the appliance is withdrawn from the cup.
Patent GB-189726511-A (GB)
Title: Certain Improvements in Animal Traps.
Inventor: SIDEBOTHAM WILLIAM
Filed: 1897-11-13
Granted: 1898-10-01
Abstract: 26,511. Sidebotham, W., and Sidebotham, G., [trading as Sidebotham,W. & G.]. Nov. 13. Traps.-Relates to spring-jaw traps for catching rats or rabbits. The jaws, which are pivoted and operated in the usual way, are covered with blocks F<1> and F<2> of rubber. The blocks F<1> and F<2> are secured to the jaws by rivets or similar fastenings and are formed with grooves or ribs f<2> to assist in retaining the animal caught.
Patent GB-189730504-A (GB)
Title: Improvements in or relating to Gasaliers.
Inventor: EDGE JAMES SIMEON
Filed: 1897-12-24
Granted: 1898-12-17
Abstract: 30,504. Edge, J. S., and Wright, J. H. Dec. 24. Gasaliers.-A valve G supportedand actuated by a float K is provided in order to prevent the escape of gas when the water level in the slide tubes C and E falls, owing to a defective tube or otherwise. When in its uppermost position the valve engages a recess M in the cam B ; it may be closed by operating this cam.
Patent GB-189801279-A (GB)
Title: Improvements in Trousers or Breeches.
Inventor: FISHER JOHN SAMUEL
Filed: 1898-01-17
Granted: 1898-04-09
Abstract: 1279. Fisher, J. S. Jan. 17. Breeches; trousers.- Trousers or breeches for men's or women's wear are made with an opening d in each leg just below the knee, the edges of which are provided with h fastenings so that the trousers can be tightly fastened around the calf of the leg to prevent them from working upwards when the wearer is riding or cycling. The opening may extend down to the bottom of the trouser legs.
Patent GB-189806174-A (GB)
Title: Improvements in Incandescent Light Burners for Liquid Hydro-carbon.
Inventor: POLLAK HUGO
Filed: 1898-03-14
Granted: 1899-02-11
Abstract: 6174. Pollak, H. March 14. Incandescent vapour lamps.- A pad saturated with spirit is ignited beneath the chamber f to start the vaporization from the #-shaped wick b. The vapour generated then traverses the tube d, which is closed at its upper end, and the tube e, from which it passes under the control of the valve m to the chamber f. Thence it escapes through the opening g to the interior of the Bunsen tube n, to which air is admitted through apertures p, and the mixture of air and vapour is ignited above a gauze s, which is retained between the upper ends of the burner tubes n, r. The air-supply apertures p are protected by a bell q resting upon the valve casing h; and the transmission of heat from the wicktube a to the oil reservoir A is prevented by the use of a well-chamber w.
Patent GB-189813313-A (GB)
Title: Improvements in and connected with Bicycle Driving Gear.
Inventor: FARFAN JOSEPH FRANCIS AMBROSE
Filed: 1898-06-14
Granted: 1899-04-22
Abstract: 13,313. Fairfan, J. F. A. June 14. Driving-mechanism for bicycles. The treadlelevers 17 are loosely mounted upon the axle 16, and have sheaves 22 mounted upon the bosses 18 thereof. A cord 26 passes round and is secured to each sheave, and is carried through the stays 8, 8<a> to a corresponding sheave 27 which is connected by clutch mechanism to the rear-wheel hub. The upper stays 8 are connected together by a brace 12 and by a strut 13 to the frame member 6, and the lower stays 8<a> are connected by a brace 14 and a strut 15 to the bottom bracket. Each of the sheaves 27 runs upon ball bearings in a ball cup 29, which is attached to the wheel hub 30. Spring- controlled dogs 33, which have their ends seated in notches 32 in the sheave, are provided with notches to receive a rib 31 mounted upon a flange 28 of the ball cup 29. By this arrangement the dogs bind upon the rib in one direction, and serve to propel -the bicycle and run freely upon the rib in the opposite direction. The treadle-lever bosses 18 are provided with recesses 19 which engage projections 20 on the bottom bracket to limit the motion of the treadle-levers. The sheaves 22 are connected by a cord 23 passing over a pulley 24 mounted in a spring frame 25 to cause the treadlelevers to swing alternately. In a modification, a clutch is mounted upon the crank axle, and motion is transmitted to the rear wheel by chain gearing. In another modification, a single length of cord is used which passes from one sheave on the crank axle to the rear clutch, through the rear stay tubes, and over a spring-controlled idle pulley to the other rear clutch, and from there to the corresponding sheave on the crank axle. An adjusting- screw may replace the spring in the idle pulley. Other forms of clutch may be used, such as ball &c. clutches, and clutches of the type described may be used in connection with the rear sprocket-wheel of an ordinary bicycle.
Patent GB-189813919-A (GB)
Title: Improvements in Water Wheels and Turbines.
Inventor: BARR ARCHIBALD
Filed: 1898-06-23
Granted: 1899-06-02
Abstract: 13,919. Barr, A. June 23. Turbines and reaction-wheels.-The power or speed of Pelton wheels &c. is regulated by passing the motive fluid through a nozzle having a part A of india-rubber or other elastic or flexible material. The flow of fluid is regulated by varying the pressure in the chamber F. As shown in the Figures, fluid passes by a passage G, controlled by a screw H, to the chamber F, whence the flow by way of a pipe I is controlled by a valve K operated by a centrifugal governor. A pump or other means may be used to control the said pressure. In a modification, a vacuum is produced in the chamber F by means of a nozzle arranged centrally within or in the wall of the nozzle A, and a regulable amount of fluid is passed by another passage to the chamber. In one form, a drum which has one or more pockets is driven by the engine and transfers a certain amount of air to the chamber F at each rotation.
Patent GB-189825398-A (GB)
Title: An Improved Sociable Tricycle.
Inventor: DORIGNY PAUL
Filed: 1898-12-01
Granted: 1899-09-30
Abstract: 25,398. Dorigny, P. Dec. 1. Motor road vehicles. -Relates to the form of front-steering sociable tricycle in which two bicycle driving-wheels are arranged side by side, and consists in the addition of a cross-frame &c. to allow the tricycle to be driven by a motor. Fig. 3 shows a plan of the tricycle, and Figs. 4 and 5 show in sectional and end elevation the cross-frame. The inner fork ends are connected by three cross-tubes N, and also carry a balance-geared axle H which is geared through pinions F, G with the hubs A of the driving-wheels. The chain-wheels are connected to the hubs of pawls and ratchet - wheels so that, when the motor is in use, the driving-wheels over-run. The motor, such as a rotary steam engine and its accessories, are detachably mounted on the cross-frame. The tricycle is fitted with the usual chain gearing, as shown in Fig. 3.
Patent GB-189903054-A (GB)
Title: Improvements in the Construction of Hollow Concrete Floors, Walls and the like.
Inventor: BREMER JOHANN CHRISTOPH AUGUST
Filed: 1899-02-10
Granted: 1899-03-18
Abstract: 3054. Bremer, J. C. A. Feb. 10. Building-blocks.-Hollow blocks A for walls &c. are produced by inserting pipes R in a mould, and filling in the mould with concrete.
Patent GB-189904902-A (GB)
Title: Process for Raising the Point of Fusion or Preventing the Liquefaction of Resins, Wax and Wax-like Substances, Pitch, and Tar.
Inventor: GENTZSCH ADOLF
Filed: 1899-03-06
Granted: 1899-04-08
Abstract: 4902. Gentzsch, A. March 6. Resins and resinous compounds.-Relates to means for raising the melting-points of resins and similar materials. The resin &c. is melted and heated to a temperature of 100‹ to 200‹ C., and water is allowed to fall drop by drop from a suitable height into the hot mass until the liquid becomes sufficiently viscous, when the supply of water is stopped and the mass is heated to remove all aqueous particles. The duration of the operation is shortened if water containing an excess of the substances, such as carbonate of calcium &c., usually found in water is used.
Patent GB-189905260-A (GB)
Title: Improvements in Hubs for Vehicle Wheels.
Inventor: JONES RICHARD
Filed: 1899-03-10
Granted: 1899-04-29
Abstract: 5260. Jones, R. March 10. Axle-boxes; hubs; spokes, securing. Relates to metallic hubs and to means for securing the spokes. The axle-box f is flanged at its inner end k, and a spoke ring c butts against the flange. The spoke ring is connected by means of the tube d to a second spoke ring c<1>, which screws on to the outer end of the axle box, and which is locked in position by a lock-nut h. Each spoke ring has a series of projections b which are internally screw-threaded to receive the screwed ends of the spokes a. A cap e and rings g are provided.
Patent GB-189905341-A (GB)
Title: Improvements in Tumbler Switches for Electrical purposes.
Inventor: WATSON ALFRED
Filed: 1899-03-11
Granted: 1899-07-08
Abstract: 5341. Watson, A., [trading as Watson & Co., A.]. March 11. Switches.- Tumbler switches are provided with a shutter which in the off position is interposed between the contacts and the contact - lever and so prevents arcing. Figs. 1 and 3 show a switch in the ' on ' and ' off ' positions respectively. The contact c is mounted on an arm c<1> pivoted at c<2>. The lower end of the lever handle e rubs over the top of the arm C', which is fitted with a stop c<5> and also with a depending finger. This finger works in a slot in the sliding shutter, and forces it back against a spring g when the switch is moved ' on.' When the switch is moved ' off,' the spring forces the shutter forward and gives a quick break.
Patent GB-189906153-A (GB)
Title: Improvements in Fluid Motor Especially Suitable as Water Meters.
Inventor: BURRELL LEONARD
Filed: 1899-03-21
Granted: 1899-05-06
Abstract: 6153. Burrell, L. March 21 Liquid meters.-Relates to improvements in the meters described in Specification No. 9899, A.D. 1898. Two double-acting cylinders a, b, with pistons a, a', b<1>, b<1>, are controlled by a single valve k which is rotated by the reciprocation of the pistons. The motion is communicated by means of racks d and loose pinions e, connected by crown ratchets g with the shaft f of the valve. The cylinders work alternately, the pistons of one being at the end of their stroke, while those of the other are at the middle of their stroke. India-rubber buffers Z are fixed to the covers a<2>, b<2>. The water enters the valve chamber at m, and leaves at l. The valve has two ports, as shown in sectional plan in Fig. 7, and the valve face four ports. The joint between the admission space m' and the exhaust space l<1> is made by a packing-ring t, which rotates with the valve ; a second packing-ring v, held up by a spring u and also rotating with the valve, prevents leakage into the chamber w containing the counter-mechanism. This chamber is provided with a hinged lid x.
Patent GB-189907769-A (GB)
Title: Improvements applicable to the "Nosing Motion" of Self-acting Mules.
Inventor: HARGREAVES JONATHAN
Filed: 1899-04-13
Granted: 1900-02-17
Abstract: 7769. Hargreaves, J. April 13. Mules. - The toothed quadrant b is made separate from the arm c, and the two are connected together by a spring f in such a manner that the arm is normally pressed against a stop b<x> on the quadrant. As the carriage approaches the end of the stretch, the lower arm of a lever h carried by a bracket g on the arm c engages with a cam-shaped stop l secured on the rod connecting the copping-plates, whereby the arm c is moved in the direction of the arrow independently of the quadrant. In a modification, the bracket g is carried by the quadrant, and the lower end of the lever h carries a pulley. The rotation of the pulley in one direction is blocked by a ratchet arrangement, and it is connected by a chain to the carriage square, so that the chain is tightened as the stretch is completed. The ratchet pulley may be adjusted by band as the cops are built up, or it may be connected by a second chain to a bracket on the rod connecting the copping-plates.
Patent GB-189909671-A (GB)
Title: New or Improved Process and Material for Impregnating Wood and the like.
Inventor: SCHENKEL JULIUS
Filed: 1899-05-08
Granted: 1899-06-24
Abstract: 9671. Schenkel, J. May 8. Wood, fireproofing.-Relates to a process of and material for impregnating wood to reduce its combustibility, without disintegrating the fibres. 50 to 100 parts of burnt lime are dissolved in solution containing 100 parts of fused calcium chloride in 350 parts of water, or in a 15 to 20 per cent. of lye of calcium chloride. The wood, which may have been previously dried or placed in a vacuum, is soaked in this solution without boiling.
Patent GB-189912329-A (GB)
Title: Improvements in Appliances for Severing the Ears from Sheaves of Corn Preparatory to Thrashing.
Inventor: HARPER CHARLES
Filed: 1899-06-13
Granted: 1899-09-02
Abstract: 12,329. Harper, C. June 13. Ears, severing from straw before thrashing.-Relates to apparatus for severing the ears from sheaves ot corn preparatory to thrashing to prevent The necessity of passing all the straw through the thrashing-machine. The apparatus may be applied to any form of thrashing-machine, or may be used independentlv. A circular cutter A with serrated edge, or. if desired, a band saw, is mounted so that its edge works in a slot in a cutting table F. The sheaves are fed from a platform B to a conveyer having prongs E which hold the sheaves and press them against the cutter A. The ears fall into a hopper not shown in Fig. 1, and are conveyed to the thrashing-drum. The sheaves after passing the cutter A fall upon a conveyer J, by which they are removed to any required place.
Patent GB-189923328-A (GB)
Title: Grippers for Cable Cars.
Inventor: FRASER SIMON ALBERT
Filed: 1899-11-22
Granted: 1900-01-27
Abstract: 23,328. Fraser, S. A. Nov. 22. Rope grips.- The jaws 5, 5<1> are carried by the pivoted levers 1, 1<1>, which are operated by the toggle-lever and links 8, 8', 10, a stop 15 holding them after passing the centre line. The lever 10 has a square 13 for turning it, and a second pair of holes for attaching the links 8, 8<1>.
Patent GB-189924326-A (GB)
Title: An Improved Method of Extracting Liquid Contents from a Bottle or like Vessel and Means therefor.
Inventor: WHITING EDWARD HERCULES
Filed: 1899-12-06
Granted: 1900-08-04
Abstract: 24,326. Whiting, E. H. Dec. 6. Emptying bottles &c.-Relates to siphon apparatus for withdrawing the contents of bottles &c. The shorter leg a of the siphon a, b is passed through a central perforation in a cork or plug, which is inserted in the neck of the bottle &c. after the ordinary cork has been withdrawn, or the end of the leg a may be formed or fitted with an integral or detachable corkscrew or other piercing-instrument, by means of which it can be passed through the ordinary cork &c. In the arrangement shown in Fig. 7, the corkscrew c falls away from the leg a, after it has passed through the cork. The discharge end of the siphon may also be formed with a socket to fit the corkscrew &c. The cork or plug may be formed with venting-apertures, or vent grooves or tubes f may be formed in or attached to the siphon tube. The longer leg b of the siphon is. provided with a discharge valve t. In the form shown in Fig. 1, the valve consists of a tube x of rubber &c., and a spiral spring n connected to two blocks m on the leg b and discharge tube w. In the normal position, as shown, the spring n holds the tube x in a bent or "kinked " position, so that it prevents the passage of the liquid. The tube x is closed by pulling down the discharge tube w against the action of the spring n, and is closed automatically when the tube w is released. In the modification shown in Fig. 1<A>, the spring n<1> is connected to the lower end of a rigid bulb or chamber i', the upper end of which screws on a ferrule i<3> on the siphon tube b. By adjusting the bulb on the ferrule, it can be made to hold the valve open, with any desired amount of opening, or any slackness in the tube x can be taken up. A conical plug cock, having a milled thumb disc at each end, may be employed instead of the valves described. In the form shown in Fig. 10, the spindle j of the cock is formed with an aperture through which the rubber tube x is passed. By rotating the spindle into the position shown, the tube x is doubly bent and so closed. A bridge-piece l on the spindle engages with a spring catch k on the casing i, to hold the cock in the closed position.