baber/WOPTO huggingface dataset:
Patent JP-2023541478-A (JP)
Title: メタン熱分解のための溶融塩反応器システム
IPC: C01B3/26
Filed: 2021-09-15
Abstract: 有効な条件でメタンを熱分解するのに活性であり、溶融塩媒体及び反応容器を含む、反応器システムであって、溶融塩が、メタンが容器を通過するときに、熱分解反応を引き起こす触媒と接触し、それによって、二酸化炭素排出量を削減して水素分子を生成するように、容器内の触媒分布の様々な方法を使用して、反応容器内に含まれている、反応器システム。触媒は、懸濁粒子として、又は構造化充填形態のいずれかで、反応容器内に配置され得る。
Patent JP-2023551399-A (JP)
Title: 加熱硬化可能なポリウレタン組成物
IPC: C08G18/38
Filed: 2021-11-30
Abstract: 少なくとも１種のポリイソシアネートと少なくとも１種のポリオールとから作成されたイソシアネート末端基を有するプレポリマーを含む、加熱硬化可能な一成分系ポリウレタン組成物における熱硬化のための硬化剤として使用される少なくとも６５℃の融点を有する窒素化合物であって、ポリアミン、ヒドラジド、又はそれらの混合物から選択される固体の窒素化合物に関する。
Patent JP-2024501926-A (JP)
Title: 力の推論の方法、順伝播型ニューラルネットワークの訓練方法、力の推論のモジュール及びセンサの構成
IPC: G01L5/166
Filed: 2021-01-08
Abstract: 【課題】ロボティクス向けセンサの構成を改良する。【解決手段】本発明は、画像データを使うセンサの構成の力の推論の方法と、対応する順伝播型ニューラルネットワークの訓練方法と、対応する力の推論のモジュールと、対応するセンサの構成に関する。
Patent JP-2024500969-A (JP)
Title: 高導電性パッシベーション層及び高アスペクト比プラズマエッチング中にそれを形成する方法
IPC: H01L21/3065
Filed: 2021-12-16
Abstract: 【解決手段】 反応チャンバー内の基板に高アスペクト比（ＨＡＲ）エッチングプロセス中にＨＡＲ構造を形成する方法が開示され、この方法は、ハイドロフルオロカーボン又はフルオロカーボン化合物と添加剤化合物とを含むエッチャントの蒸気に基板を逐次的に又は同時に曝露することであって、基板が、その上に配置された膜と、膜上に配置されたパターン化されたマスク層とを有すること；プラズマを活性化して、活性化されたハイドロフルオロカーボン又はフルオロカーボン化合物と活性化された添加剤化合物とを生成すること；及びパターン化されたマスク層によって覆われていない膜と、活性化されたハイドロフルオロカーボン又はフルオロカーボン化合物及び活性化された添加剤化合物との間でエッチング反応を進行させて、パターン化されたマスク層から膜を選択的にエッチングし、それによってＨＡＲパターン化構造を形成すること；を含む。【選択図】図５
Patent JP-2024500491-A (JP)
Title: 情報伝送方法及び装置
IPC: H04W72/0453
Filed: 2021-12-02
Abstract: 本願は、通信技術の分野に関し、情報伝送方法及び装置を提供し、３２０ＭＨｚ帯域幅における伝送のためにＰＰＤＵのＰＡＰＲを低減する。情報伝送方法は、送信デバイスが、３２０ＭＨｚ帯域幅のＰＰＤＵを生成する段階を備え、ここで、ＰＰＤＵの一部又は全部のフィールドは、回転ファクタシーケンスに基づいて３２０ＭＨｚ帯域幅において回転され、３２０ＭＨｚ帯域幅は、１６個の２０ＭＨｚサブチャネルを含み、回転ファクタシーケンスは、１６個の回転ファクタを含み、各２０ＭＨｚサブチャネルは、１個の回転ファクタに対応する。送信デバイスはＰＰＤＵを送信する。例えば、回転ファクタシーケンスは、［１，１，１，１，１，－１，１，１，－１，－１，－１，１，１，－１，１，－１］であり得る。
Patent JP-2024502422-A (JP)
Title: 電子機器及びその撮像モジュール
IPC: H04N23/50
Filed: 2021-12-29
Abstract: 本出願は、電子機器及びその撮像モジュールを開示し、撮像モジュールは、感光チップと、第一のレンズと、第二のレンズと、複数の反射部材とを含み、感光チップは、ベイヤ配列センサであり、感光チップは、行列状に配列される複数の画素領域を含み、各画素領域は、いずれも四つのサブ画素領域を含み、第一のレンズと第二のレンズの視野は、同じであり、第一のレンズと第二のレンズは、いずれも複数の反射部材を介して感光チップと組み合わせ、第一のレンズから入射される光線は、感光チップの第一のサブ画素領域によって第一の画像を形成し、第二のレンズから入射される光線は、感光チップの第二のサブ画素領域によって第二の画像を形成し、第一の画像と第二の画像の内容は、同じであり、第一のサブ画素領域と第二のサブ画素領域が同一の画素領域内における等価サブ画素領域は、この画素領域のうちのいずれか二つのサブ画素領域である。
Patent JP-2024502449-A (JP)
Title: 炭化水素からの水素の生成
IPC: C01B3/24
Filed: 2022-01-07
Abstract: 【解決手段】水素を生成する方法は、金属およびハロゲン化物を含む金属塩を昇華させて、金属およびハロゲン化物を含む気相金属塩を生じさせるステップと、気相金属塩を気相炭化水素と接触させて、元素形態の金属、元素形態の炭素、水素ガス、およびハロゲン化物を含むハロゲン化水素を生じさせるステップと、を含む。【選択図】図７
Patent JP-2023550212-A (JP)
Title: 医薬品コードを決定するための方法、装置、電子機器及びコンピュータ媒体
IPC: G06F16/31
Filed: 2021-12-15
Abstract: 医薬品コードを決定するための方法と装置であって、人工知能技術の分野に関する。当該方法は、医薬品の説明書テキストを取得するステップ（２０１）と、説明書テキスト中の医薬品のキー情報を抽出するステップ（２０２）と、予め作成されたコード転置インデックスに基づいて、医薬品のキー情報に関連する少なくとも１つのコード及び各コードに対応する成分を得るステップ（２０３）と、医薬品のキー情報及び各コードに対応する成分に基づいて、少なくとも１つのコードをスクリーニングすることで、医薬品の解剖治療化学分類システムコードを得るステップ（２０４）と、を含む。当該方法は、医薬品のコードを検索する効率を向上させることができる。【選択図】図２
Patent MX-2007000289-A (MX)
Title: Substituted heteroaryl- and phenylsulfamoyl compounds.
Inventor: HAMANAKA ERNEST SEIICHI
IPC: A61K31/00
Filed: 2005-06-17
Abstract: The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds,pharmaceutical compositions containing such compounds and the use of such compoundsas peroxisome proliferator activator receptor (PPAR) agonists. PPAR alphaactivators, pharmaceutical compositions containing such compounds and theuse of such compounds to elevate certain plasma lipid levels, including highdensity lipoprotein-cholesterol and to lower certain other plasma lipid levels,such as LDL-cholesterol and triglycerides and accordingly to treat diseaseswhich are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesteroland triglycerides, such as atherosclerosis and cardiovascular diseases, inmammals, including humans. The compounds are also useful for the treatment ofnegative energy balance (NEB) and associated diseases in ruminants.
Patent MX-2007001340-A (MX)
Title: Process for the preparation 2-substituted-derivatives of estrone and estradiol.
Inventor: STOELWINDER JOHANNES
IPC: C07J75/00
Filed: 2005-08-01
Abstract: The invention provides a process for the preparation of 2- substituted-derivatives ofestrone and estradiol comprising i) the preparation of a compound of general formula(II) by reacting a compound of general formula (I) in one or more steps to a compoundof general formula II wherein Rl is a C1-C10 alkyl, alkenyl or aryl group; -C1,-Br, -I, -F; -CN; -OH; or a -OR2, -O(CO)R2 or -R2-OH group, wherein R2 is an alkylor alkylene group having 1-6 C atoms; and the bonding between atoms 9 and 10 is asingle or a double bond. ii) aromatization of the compound of general formulaII to a compound of general formula III wherein Rl and R2 have the above definedmeanings; and iii) optionally, reduction of the compound of general formulaIII to a compound of general formula IV wherein Rl and R2 have the above definedmeanings . Furthermore the invention provides several novel compounds, whichcan be intermediates in the above process, and processes to prepare these novelcompounds . The invention also provi des 2-alkoxy-estrone, 2-alkoxy- estradiolor mixtures thereof essentially free from other estrogenic intermediates.
Patent MX-2007003346-A (MX)
Title: Double-chamber ampoule.
Inventor: HANSEN BERND
IPC: A61J1/00
Filed: 2005-07-26
Abstract: The invention relates to a receptacle comprised of an elastically flexible plasticmaterial, comprising a dosing chamber (10), inside of which a medium to be dischargedis located. One end of the dosing chamber (10) has a discharge opening (18), andthe opposite end is connected via a junction point (20) to a compressible receptaclepart (22) inside of which an, in particular, gaseous propelling medium is located.When compressing the receptacle part (22), the propelling medium forces, atleast in part, the medium to be discharged out of the dosing chamber (10) via thedischarge opening (18). An increased functional reliability in every applicationis ensured by virtue of the fact that the junction point (20) between the dosingchamber (10) and the receptacle part (22) is formed by a bottleneck provided forcreating a capillary effect that, independent of the spatial position of thereceptacle, prevents a transfer of the medium to be discharged from the dosingchamber (10) into the receptacle par t (22) containing the propelling medium.
Patent MX-2007009917-A (MX)
Title: Radial expansion of a wellbore casing against a formation.
Inventor: COSTA SCOTT
IPC: E21B47/00
Filed: 2006-02-09
Abstract: Radial expansion of a wellbore casing against a formation.
Patent MX-2007010319-A (MX)
Title: Bonded hybrid structure.
Inventor: NAUGHTON PADRAIG J
IPC: B60R19/03
Filed: 2006-02-24
Abstract: The present invention includes devices and methods of forming a structural component of a transportation vehicle and preferably an automotive vehicle. The invention includes a hybrid structure, preferably formed of two or more components that are bonded together with an adhesive to form a structural component that is lighter in weight than that of traditional components formed out of metal. The hybrid component is also substantially free of an over-molding process. Advantageously, one or more snap-fits or the like may be used to position and maintain spatial relationship of the two or more components during assembly, and compression and curing of the adhesive.
Patent MX-2007011128-A (MX)
Title: Improved method for preparing metal-matrix composite and device for implementing said method.
Inventor: TSCHOFEN JACQUES
IPC: C22C1/10
Filed: 2006-03-14
Abstract: The invention mainly concerns a method for preparing metal-matrix composites including at least steps of cold-process isostatic compaction of previously mixed powders (5) and of hot-process uniaxial pressing of the compact (12) resulting from the previous step. The inventive method enables metal-matrix composites with improved properties to be obtained. The invention also concerns a device for implementing in particular the isostatic compaction step comprising a latex sheath (1) wherein the mixture of powders (5) is poured, a perforated cylindrical container (2) wherein is arranged the latex sheath (1), and means (7, 10, 11) for sealed insulation of the mixture of powders (2) contained in the sheath (1).
Patent MX-2007012585-A (MX)
Title: Apparatus and method for recovering oil-based drilling mud.
Inventor: BROWNE NEALE
IPC: E21B21/00
Filed: 2006-04-11
Abstract: An apparatus for preparing used oil-based drilling fluid for recovery includes a first dosing pump dispensing a predetermined amount of surfactant into the oil-based drilling fluid, a first static mixer mixing the oil-based drilling fluid and the surfactant to form a surfactant treated drilling fluid, a second dosing pump dispensing a predetermined amount of flocculating polymer into the surfactant treated drilling fluid, and a plurality of serially aligned mixers mixing the surfactant treated drilling fluid and the flocculating polymer.
Patent MX-2007015954-A (MX)
Title: Pantoprazole multiparticulate formulations.
Inventor: PETEREIT HANS-ULRICH
IPC: A61K31/522
Filed: 2006-04-05
Abstract: Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
Patent MX-2008001991-A (MX)
Title: Oxidizing hair coloring agents containing m-aminophenol derivatives.
Inventor: CHASSOT LAURENT
IPC: A61Q5/06
Filed: 2006-08-09
Abstract: The object of the present patent application are agents for the oxidative coloring of keratin fibers, particularly hair, based on a developer substance-coupler substance combination, characterized in that they contain at least one meta-aminophenol derivative of general formula (I) , wherein Rl denotes hydrogen, a C1-C6 alkyl group, a C2-C4 hydroxyalkyl group, a C2-C4 dihydroxyalkyl group, a C1-C4 alkoxy group or a halogen atom; and R2 denotes hydrogen, a hydroxy group, a carboxylic group, an aminocarbonyl group or a hydroxymethyl group.
Patent MX-2008004170-A (MX)
Title: Long-lasting cosmetic composition, method for using, and process for making.
Inventor: HANNA FIFI G
IPC: A61Q1/10
Filed: 2005-09-30
Abstract: There is a cosmetic composition that has an anhydrous gel phase having a gellant and an organic solvent, an aqueous phase having a hydrophilic film former and water, and a wax phase having a wax and a hydrophilized lanolin derivative. The anhydrous gel phase, the aqueous phase, and the wax phase are substantially homogeneously admixed. The hydrophilized lanolin derivative is present in an amount sufficient to adsorb the aqueous phase. There is also a method of imparting curl, length, thickness, and/or color to eyelashes. There is further a process for making a cosmetic composition.
Patent MX-2008004372-A (MX)
Title: Method of feeding young monogastric mammals and composition fed to young monogastric mammals.
Inventor: MILLER BILL L
IPC: A23K1/00
Filed: 2008-04-01
Abstract: A method of feeding a monogastric mammal, the method including feeding the monogastric mammal a milk replacer during a feeding period and feeding the monogastric mammal a psyllium composition during the feeding period.
Patent MX-2008014522-A (MX)
Title: Diagnostic test media and methods for the manufacture thereof.
Inventor: WEGNER GRETA
IPC: B41M3/00
Filed: 2007-05-03
Abstract: The present disclosure relates to the manufacture of diagnostic test media used for measuring the concentration of anaiytes in a sample fluid. More specifically, the disclosure relates to using a method of microcontact printing or mlcrotransfer molding for the manufacture of diagnostic test media.
Patent MX-2008014940-A (MX)
Title: Pipe insert.
Inventor: BELFORD JAMES WALLACE
IPC: F16L33/22
Filed: 2007-05-30
Abstract: There is provided an insert to be sealingly mounted into a plug hole of a pipe having a sealing area surrounding the plug hole. The insert comprises an internal unit (20) and a fastener (30). The internal unit and the fastener have corresponding cooperating sealing portions and mounting portions. The sealing portion of the internal unit is formed with a flange (22) adapted to be forced into the plug hole. The flange and the sealing portion of the fastener have corresponding sealing surfaces. These surfaces are adapted to sealingly clamp therebetween the sealing area of the pipe, when the insert is mounted into the plug hole. One of the sealing surfaces being in the form of a sealing edge (23) and the other being in the form of a conical surface (32). When the fastener is mounted onto the internal unit, the sealing portions of the internal unit and the fastener form therebetween a chamber. The chamber is in fluid communication with the outside environment, allowing atmospheric pressure within the chamber.
Patent MX-2009000480-A (MX)
Title: Benzyl amines, a process for their production and their use as anti-inflammatory agents.
Inventor: BERGER MARKUS
IPC: C07D401/12
Filed: 2007-07-16
Abstract: The present invention relates to the compounds of formula (I), processes for their production and their use as anti-inflammatory agents.
Patent MX-2009001360-A (MX)
Title: Fired refractory ceramic product.
Inventor: REITERER FRANZ
IPC: C04B35/66
Filed: 2007-08-08
Abstract: The invention relates to a fired refractory ceramic product. According to the invention, this generic term encompasses both shaped and unshaped products. Shaped products are ones which have a defined shape so that they can be manufactured in finished form on the premises of the manufacturer. Shaped products include: bricks, nozzles, tubes, stoppers, plates, etc. The term unshaped products includes ones which are usually produced by the user from a corresponding composition. They include bases for furnaces which are cast from a composition but also repair compositions, etc.
Patent MX-2009002294-A (MX)
Title: Network jitter smoothing with reduced delay.
Inventor: WANG TIAN
IPC: H04L47/30
Filed: 2007-08-28
Abstract: A method of compensating for jitter in a packet stream is described. The method comprises placing undecoded frames extracted from packets in the packet stream into a jitter buffer while decoding frames from the jitter buffer and placing the decoded frames into a sample buffer at a rate determined using an average playout delay. The average playout delay is the running average of the playout delay calculated for each packet as each packet becomes available. The playout delay for each packet is the sum of a sample buffer delay and a jitter buffer delay. As each packet is received, the average playout delay is adjusted based on a comparison of the playout delay associated with the received packet to the current average playout delay.
Patent MX-2009002428-A (MX)
Title: Peel-to-open packages.
Inventor: MILLER CHRISTOPHER MILES
IPC: B65D75/20
Filed: 2007-08-30
Abstract: Improved peel-to-open packages (1000) including sachets, pouches, and the like are disclosed. The packages are made of substrate layers (10, 20) removably adhered together using an adhesive pattern of seal(s) that are characterized by peel forces. The adhesive pattern is designed to provide for controlled opening of the packages, in some embodiments to a predetermined stopping point, such that any product (s) contained therein are presented to the consumer for removal. Further design features include, but are not limited to, offset tabs (700A, 700B), textures, color variations and text, which may further provide for easy, intuitive opening.
Patent MX-2009006040-A (MX)
Title: Method for obtaining a porous structure based on silicon carbide.
Inventor: ANDY PATRICIA
IPC: C04B38/00
Filed: 2007-12-13
Abstract: The invention relates to a method for obtaining a structure made from a porous ceramic material containing at least 95% silicon carbide SiC, said method being characterised in that the structure is obtained from a mixture of SiC grains comprising at least: a first fraction of Î±-SiC grains having a median diameter of less than 5 micrometers, a second fraction of Î±-SiC grains having a median diameter which is at least twice that of the first fraction of Î±-SiC grains and is greater than or equal to 5 micrometers, and a fraction of Î²-SiC grains or at least one precursor of Î²-SiC grains. The invention also relates to the resulting porous structure.
Patent MX-2009006213-A (MX)
Title: Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors.
Inventor: PETERS DAN
IPC: C07D451/06
Filed: 2007-12-18
Abstract: This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Patent MX-2009006706-A (MX)
Title: Bicyclic heterocyclic compounds as fgfr inhibitors.
Inventor: CONGREVE MILES STUART
IPC: C07D471/04
Filed: 2007-12-21
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Patent MX-2009007103-A (MX)
Title: Precipitated silica materials exhibiting high compatibility with cetylpyridinium chloride.
Inventor: MCGILL PATRICK
IPC: A61K8/00
Filed: 2007-11-08
Abstract: Precipitated silica comprising porous silica particles having a cumulative surface area for all pores having diameters greater than 500 Ã¿ of less than 6 m2/g, as measured by mercury intrusion, and a percentage cetylpyridinium chloride (% CPC) Compatibility of greater than about 85%. The precipitated silica product is especially well-adapted for use in dentifrices containing cetylpyridinium chloride, which do not attach to the low surface area silica product in a meaningful level and thus remain available for antimicrobial action. Processes for making the silica product including the introduction of sodium sulfate powder during different process steps in order to enhance such a compatibility with CPC are provided.
Patent MX-2009009788-A (MX)
Title: Method for improving the draining performance by starting and stopping the hydraulic pump in washing machines.
Inventor: JAIME EMMANUEL RODRIGUEZ DECANINI
IPC: D06F51/00
Filed: 2009-09-11
Abstract: The present invention presents a novel method for improving the draining performance by starting and stopping the hydraulic pump in washing machines. The method, in a general manner, consists in detecting and monitoring the revolutions per minute at which the main engine of the tub is rotated; according to that information the suitable moment for stopping the hydraulic pump is detected so as to remove the air bubble that damages the draining performance.
Patent MX-2010001939-A (MX)
Title: Method for fabric treatment at low ph.
Inventor: GHOSH TIRTHANKAR
IPC: D06M11/83
Filed: 2010-02-18
Abstract: A composition useful for treating fabrics. The composition contains a silver-containing copolymer having polymerized units of a monomer X which is an ethylenically unsaturated compound having a substituent group selected from an unsaturated or aromatic heterocyclic group having at least one nitrogen atom and polymerized units of a monomer Y which is an ethylenically unsaturated compound selected from carboxylic acids, organosulfuric acids, sulfonic acids, phosphonic acids and esters comprising polymerized units of ethylene oxide.
Patent MX-2010004626-A (MX)
Title: A multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said rocedure.
Inventor: BARROS CARLOS DE BAEREMAECKER
IPC: A61K39/00
Filed: 2008-10-30
Abstract: The main objective of the present invention is to obtain a vaccine against the Chagas disease, capable of stimulating the immune response against the trans- sialidase virulence factor of the Trypanosoma Cruzi parasite, distinguished by the fact that said vaccine comprises a multicomponent vaccine for the Chagas disease (tripanosomiasis americana) distinguished by the fact that it comprises: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, both portions for the Trypanosoma Cruzi derivates (i.e., T. Cruzi and or a conserved region common to many of them) where the vaccine administration is a protection against the parasite infection, eliminates it or reduces the clinical consequences of said infection. Another objective of the present invention is a monocomponent vaccine against the Chagas disease comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions that codifying one or more immunogenic polypeptides derived from Trypanosoma Cruzi (i.e. a T. Cruzi and /or a conserved region common to many of them) where the immunogenic portion or the polynucleotides group stimulates an antibody response, of CD4+ Th1 biased T cells or CD8+ T cells against the Trypanosoma Cruzi. This invention also includes: the pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
Patent MX-2010007618-A (MX)
Title: Method and apparatus for providing a positive pressure in the headspace of a plastic container.
Inventor: LIVINGSTON DARREN D
IPC: B65D53/00
Filed: 2009-01-09
Abstract: The present invention is directed to a method and apparatus for accommodating the pressure decrease of the fluid in a hot-filled plastic container.
Patent MX-2010008654-A (MX)
Title: Fermentation media comprising urea-like nitrogen sources and its use for the production of secondary metabolits, enzymes and recombinant proteias.
Inventor: GOEL ANUJ
IPC: C12N1/20
Filed: 2009-02-05
Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.
Patent MX-2010014235-A (MX)
Title: 4-(pyridin-4-yl)-1h-(1, 3, 5)triazin-2-one derivatives as gsk3-beta inhibitors for the treatment of neurodegenerative diseases.
Inventor: SAADY MOURAD
IPC: A61P35/00
Filed: 2009-06-25
Abstract: A triazinone derivative represented by formula (I) wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a Ci-Î² alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. The compounds of the present invention have GSK3Î² inhibitory activity and are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activity of GSK3Î² and more particularly of neurodegenerative diseases.