Patent SG-11201809642T-A (SG)
Title: Anti-factor ix padua antibodies
Inventor: VOELKEL DIRK
IPC: G01N33/50
Filed: 2017-05-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111101111111111101111111011110111111 Organization - - - ' International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\") WO 2017/200981 Al 23 November 2017 (23.11.2017) WIPO I PCT — (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) (72) International Patent Classification: (74) Agent: SULLIVAN, Nicole, R.; Troutman Sanders LLP, C07K 16/00 (2006.01) C07K 16/36 (2006.01) 875 Third Avenue, New York, NY 10022 (US). C07K 16/34 (2006.01) G01N 33/50 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, PCT/US2017/032808 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 16 May 2017 (16.05.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Priority Data: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 62/337,118 16 May 2016 (16.05.2016) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/340,834 24 May 2016 (24.05.2016) US (84) Designated States (unless otherwise indicated, for every Applicant: BAXALTA INCORPORATED [US/US]; kind of regional protection available): ARIPO (BW, GH, 1200 Lakeside Drive, Bannockburn, IL 60015 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventors: VOELKEL, Dirk; Stadlbreitener Anger 17, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A-1220 Vienna (AT). PACHLINGER, Robert; Toeller-EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, gasse 42/4/26, A-1220 Vienna (AT). ROTTENSTEINER, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Hanspeter; Haidgasse 10/17, A-1020 Vienna (AT). WE- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, BER, Alfred; Skraupstrasse 24/42/8, A-1210 Vienna (AT). KM, ML, MR, NE, SN, TD, TG). = Title: ANTI-FACTOR IX PADUA ANTIBODIES FIR SIGNAL PEPTIDE PROPEPTIDE LIGHT CHAIN ir IOLLSYLLSAECCULDHENANKILBEMYNKKLEEFKMERECEM (54) EEE (OFEEAREVEENTEPTTEFIET77\"7 0 =IFGGSCITD=NSYECWC7CFEMCELDVTCNI! IItl = PC , , 'MT: - \" - ''''F r 'PVP : PC,GRVSVSQS,1511377F1 7 71711§ ACTIVATION PEPTIDE _ 1. - r ,,,- I . TATCGGSIV11KWI,,i?Aii it \"C'vt(1 IVEIT F ,E; - TriF 9.1.''E-\"- : '\"' LELDETT,UNSW?ICTADYne HEAVY CHAIN ENIZLE666YVVEKGRSALVLULRULVDRA7C116717IYNNMFCAGFHEGGES4 IGDSGGP3VTEVEGTSELTG - ISFGErAMKGEG - YTKVSTIVNN - F 7 KTKL7i FIX.PADUA: VI; :I=NAESPG=LLSYLLSAECTVELDENANICLNESPINSGKLEONGSLERECEEK CSFEERFEENTER7EFEQYVDGIVESUCLKGSCEDINSYECW,OP7FEMICELDVTONI ITGRCEUCKNSADNKTVCSCHGYPIAINQKSCEPAVHKGRVSVSTSKLIRLEITPDVIMS TEAETILDNITQSTOFNDF7RVVGGEDAITTOKTVLNGINJAFCGGSTVNEKWIVTAAHCVETG VETVVAGERKEETEHTENRNVIRIPENYNAAINENHDIALLELDEPPLNSYVTP=C:EKE 71171,KFSSMSGWGRVFHERSALTORWLVDPATOLLSTFT7YMNI 7 CASFHEGGRDSCQ GDSGG?HVIEVEGTSFLTGESKEECAMKGEG:YTKVSRYVNWIFIKTKLT PADUAULITANT: REPLACEMENT OF THE AMINO ACID ARGINI NE (R) TO LEUCINE (L) AT POSITION 384 LEADS TO A' YPERFUNCTIONAL FIX ACTIVITY (310X). POSITION 3841S POSITION 338 OF THE MATURE PEPTIDE SEQUENCE WHICH EXCLUDES SIGNAL PEPTIDE AND PROPEPTIDE. FIGURE 1 : Provided herein are anti-Factor IX Padua binding constructs, e.g., antibodies and antigen-binding fragments thereof. polypeptides, conjugates and kits are also provided. The inventions may be used in methods of detecting Factor IX Padua in sample. = = = --- = = = = = = --- = — 1-1 1-1 GC 01 © r'l IN (57) 1-1 cz Related N a O [Continued on next page] WO 2017/200981 Al MIDEDIM01101010111010111001010101101MERHI1110VOIMIE Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))