baber/WOPTO huggingface dataset:
Patent PT-732078-E (PT)
Inventor: STEFANCHIK DAVID
IPC: A61B17/128
Filed: 1995-09-01
Abstract: A clip applier and method for ligating a tissue structure is provided. The applier has a two stage actuation. In the first stage, a tissue structure is positioned into the jaws of the clip applier The jaws close and lock to a preset force to compress and temporarily occlude the tissue structure. If satisfactorily positioned, the second stage is initiated in which a clip is advanced through the shaft of the clip applier in a closed position. At the distal end of the clip applier, the clip is opened slightly to capture the pre-compressed tissue structure, and is placed over the structure. The clip is then dissociated from the business end of the instrument. Preferably the clip comprises two leg members disposed in close proximity to one another joined from opposing directions by a connecting element. The connecting element restricts separation of the leg members with opposing spring members so as to provide substantially uniform parallel deflection of the leg members from each other. <IMAGE>
Patent PT-681444-E (PT)
Inventor: MARAFANTE GENTILE
IPC: A47L9/06
Filed: 1994-11-25
Abstract: PCT No. PCT/EP94/03898 Sec. 371 Date Jul. 21, 1995 Sec. 102(e) Date Jul. 21, 1995 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/14421 PCT Pub. Date Jun. 1, 1995A floor care appliance, in particular a vacuum cleaning appliance, for example a vacuum cleaner (1) or a floor polisher, with downwardly directed bristles (11) arranged preferably around its outer periphery, the bristles (11) being fixed in a mounting strip (13), and the mounting strip (13) being positively held in a downwardly open receiving groove portion (14) of sidewalls (16, 19) inwardly extending projections (17, 24) being disposed on the sidewalls (16, 19). In order to enable force-free installation and removal of the mounting strip fitted with the bristles, the projections (24) of one sidewall (19) are displaceable into a release disposition for the mounting strip (13).
Patent PT-744947-E (PT)
Inventor: DESAI SUBHASH
IPC: A61K9/20
Filed: 1995-01-04
Abstract: Pharmaceutical compositions having a modified release profile for once daily dosing of metronidazole, methods for making the pharmaceutical compositions, and methods for treating a microbial infection with once daily dosing of the pharmaceutical compositions of the invention are provided. The compositions given once daily exhibit substantial bioequivalence to immediate release metronidazole given three times per day. The compositions of the invention comprise: (a) a first portion of metronidazole which is about 59 wt % to about 79 wt % metronidazole; (b) about 1.5 wt % to about 3.0 wt % of an aqueous insoluble poly(meth)acrylic acid ester copolymer which is aqueous permeable, aqueous expandable and pH-independent; (c) about 0.1 wt % to about 2.0 wt % detackifier; (d) 0 to about 23 wt % of a first aqueous soluble pharmaceutical diluent; (e) 0 to about 23 wt % of a second aqueous soluble diluent which is suitable for forming a pharmaceutical tablet when compressed with the granules of (a), the second aqueous soluble diluent being the same as or different from the first aqueous soluble diluent; (f) 0 to about 20 wt % of a second portion of metronidazole; (g) 0 to about 0.2 wt % glidant; and (h) 0 to about 2 wt % lubricant; wherein the composition comprises metronidazole containing granules comprising (a), (b), (c) and (d), wherein the sum of the weight percentages of metronidazole provided by (a) and (f) is between about 72 wt % and about 79 wt %, and wherein the sum of the weight percentages of the aqueous soluble diluent provided by (d) and (e) is between about 16 wt % and about 23 wt %.
Patent PT-763049-E (PT)
Inventor: ZILCH HARALD
IPC: C07H19/04
Filed: 1995-05-23
Abstract: The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) <CHEM>     wherein   R<1>   may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R<2>   may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X   represents sulfur, a sulfinyl or sulfonyl group;and   Nucl. represents     2',3'-Didesoxy-2',3'-difluorothymidine     2'-Desoxy-2'-aminoadenosine     2'-Desoxy-2'-azidoadenosine     2'-Desoxy-2'-azidocytidine     2'-Desoxy-5-fluorouridine     2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.
Patent PT-800505-E (PT)
Inventor: SHIRE MARY
IPC: A61K31/195
Filed: 1995-11-20
Abstract: Novel aryl amides are inhibitors of tumor necrosis factor  alpha  and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide.
Patent PT-815041-E (PT)
Inventor: LAIDLER KEVIN OSWALD
IPC: B05B15/525
Filed: 1996-02-28
Abstract: A hollow body having a nozzle opening to discharge fluid as a jet or spray; the body comprising a first part having an inlet to admit fluid under pressure into the first part, and a second part movable relative to the first part and said first and second parts are relatively movable from an abutting position in which they define therebetween the nozzle opening and a fluid feed passage in the body and leading to the nozzle opening, and a cleaning position in which the fluid feed passage is split open longitudinally and the nozzle opening is split open to expose the nozzle and passage defining and abutting surfaces of said parts, for cleaning.
Patent PT-833636-E (PT)
Title: Method for inhibiting neoplastic disease in mammals
Inventor: MEIER ALBERT H
IPC: A61K45/00
Filed: 1996-06-05
Abstract: This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
Patent PT-830130-E (PT)
Inventor: BLACK ROY A
IPC: C12N1/15
Filed: 1996-06-03
Abstract: A metalloprotease that converts TNF- alpha  from the 26kD cell form to the cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
Patent PT-842014-E (PT)
Inventor: ACKERET PETER
IPC: B25C5/02
Filed: 1996-07-29
Abstract: The pocket tool kit, mainly for office use, has a first component (20) and a second component (22), movably connected to each other to move between a first position forming a basically rectangular body, and a second position in which a free space between them is accessible. Each of the main components is itself in the shape of an elongated rectangular body. These body components are hollow, with a base surface (2/3), a cover surface (4, 5), two side surfaces (6/8, 7/9) and two endface surfaces (10/12, 11/13). (This covers the first two claims; there are 185 further claims).
Patent PT-1018897-E (PT)
Inventor: ULRIK RUBOW
IPC: A61L2/07
Filed: 1996-12-03
Abstract: PCT No. PCT/DK96/00505 Sec. 371 Date Jun. 2, 1999 Sec. 102(e) Date Jun. 2, 1999 PCT Filed Dec. 3, 1996 PCT Pub. No. WO98/24333 PCT Pub. Date Jun. 11, 1998A method and installation for disinfection or sterilization of food articles or machinery, in which the item of food or machinery to be disinfected or sterilized is electrically grounded, and vapor from water or other liquid substance is generated and directed through an electrostatic potential field of defined shape generated with an electrostatic high voltage, whereby the vapor assumes the shape of the field with an electrostatic potential imposed thereon. The grounded item is exposed to the charged vapor for a predetermined time at a temperature above 50 DEG  C.
Patent PT-868500-E (PT)
Inventor: MULLER HEINZ
IPC: C09K17/22
Filed: 1996-12-13
Abstract: PCT No. PCT/EP96/05602 Sec. 371 Date Dec. 22, 1998 Sec. 102(e) Date Dec. 22, 1998 PCT Filed Dec. 13, 1996 PCT Pub. No. WO97/23579 PCT Pub. Date Jul. 3, 1997The invention relates to a process for intensifying the surface stabilization of soil susceptible to erosion by introduction of water-based adhesion-promoting impregnating compounds based on esters of polyvinyl alcohol with C1-5 monocarboxylic acids and mixtures thereof with higher monocarboxylic acids (binders) using surface-active and biologiclly compatible wetting agents. The process is characterized in that impregnation of the soil is carried out in several stages and in that an aqueous preparation containing the wetting agents is used at least in the first impregnating stage. Binder is preferably used in a comparatively small quantity in this pre-impregnation stage.
Patent PT-876561-E (PT)
Inventor: HOOGENBERG HEERKE
IPC: F16H15/54
Filed: 1997-11-19
Abstract: PCT No. PCT/NL97/00632 Sec. 371 Date Dec. 1, 1998 Sec. 102(e) Date Dec. 1, 1998 PCT Filed Nov. 19, 1997 PCT Pub. No. WO98/22729 PCT Pub. Date May 28, 1998The invention relates to a mechanical transmission, which transmission includes guide members for realizing a rotational translating movement of a wheel which is connected to an output shaft and which makes contact with an endless belt of mutually abutting push links, which guide members are assembled from at least two linear guide tracks received mutually perpendicularly in the same plate and guide elements co-acting with the linear guide tracks, wherein guide elements are connected to the wheel for rotational translation and guide elements are rigidly connected to the frame whereby the plate is movable in linear manner relative to the frame and the wheel is displaceable in linear manner relative to the plate.
Patent PT-912611-E (PT)
Inventor: DAGAN SHLOMO
IPC: A61K39/00
Filed: 1997-06-10
Abstract: Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines, and antibodies produced by the cell lines. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are engrafted into normal strains of mice which were lethally irradiated and radioprotected with SCID bone marrow. After immunization of such chimeric mice with HBVsAg, human cells are obtained from the mice spleens and fused in vitro with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.
Patent PT-952823-E (PT)
Inventor: TOTH ANTAL
IPC: A61K38/55
Filed: 1997-12-15
Abstract: The invention relates to pharmaceutical compositions of enalapril maleate stabilized by maleic acid.
Patent PT-994963-E (PT)
Inventor: LO YUK-MING
IPC: C12Q1/6879
Filed: 1998-03-04
Abstract: The invention relates to a detection method performed on a maternal serum or plasma sample from a pregnant female, which method comprises detecting the presence of a nucleic acid of foetal origin in the sample. The invention enables non-invasive prenatal diagnosis including for example sex determination, blood typing and other genotyping, and detection of pre-eclampsia in the mother.
Patent PT-986753-E (PT)
Inventor: THASTRUP OLE
IPC: G01N33/50
Filed: 1998-04-07
Abstract: Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Fluorescent Protein (GFP,EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent protein kinase, a cyclin-, calmodulin- or phospholipid-dependent or mitogen-activated serine/threonin protein kinase, a tyrosine protein kinase, or a protein phosphatase (e.g. PKA, PKC, Erk, Smad, VASP, actin, p38, Jnk1, PKG, IkappB, CDK2, Grk5, Zap70. p85, protein-tyrosine phosphatase 1C, stat5, NFAT, NFkappaB, RhoA, PKB). An influence modulates the intracellular signaling pathway in such a way that the luminophore is being redistributed or translocated with the component in living cells in a manner experimentally determined to be correlated to the degree of influence. Measurement of redistribution is performed by recording of light intensity, fluorescense lifetime, polarization, wavelength shift, resonance energy transfer, or other properties by an apparatus consisting of e.g. a fluorescence microscope and a CCD camera. Data stored as digital images are processed to numbers representing the degree of redistribution. The method can be used as a screening program for identifying a compound that modulates a component and is capable of treating a disease related to the function of the component.
Patent PT-998493-E (PT)
Inventor: PETER BURNIE JAMES
IPC: A61K39/00
Filed: 1998-07-17
Abstract: The present invention concerns immunogenic epitopes of Shigella-like toxins (SLTs), particularly the Shigella-like toxin of E. coli 0157:H7, their use as immunogens and in treatment or diagnosis, agents (for example antibodies and antigen-binding fragments) which specifically neutralise them, their use in treatment and diagnosis, and methods for same.
Patent PT-1082291-E (PT)
Inventor: MARZI MAURO
IPC: C07C227/32
Filed: 1999-05-18
Abstract: A process is described for the stereoselective synthesis of R-(-)-carnitine in which the characterizing step is condensation of glycerol with an amine of (-)camphorsulfonic acid.
Patent PT-1112231-E (PT)
Inventor: FRANCOIS VIRLOGET
IPC: C02F3/06
Filed: 1999-08-11
Abstract: The invention concerns a method for treating effluents in small communities, that is communities consisting of about 200 to 2000 inh.eq (inhabitant equivalent), characterised in that it consists in: carrying out a biological treatment of the effluent using a trickling filter eliminating matters suspended in the treated effluent, and, simultaneously performing a treatment of the sludge by filtering-composting on filters planted with reeds.
Patent SG-65983-G (SG)
Title: Hair curler
IPC: A45D2/24
Filed: 1983-11-02
Abstract: A hairdressing implement, especially a hair curler which can be electrically heated, comprises a handle from which a curling mandrel extends, this mandrel being provided with a plurality of combs each having a pivotal bar parallel to the mandrel axis and disposed in angularly equispaced relationship therearound so that a free space is provided to accommodate a heater. A sleeve through which the tines of the combs pass, is rotatable relative to the mandrel body to swing the tines beneath the surface of the sleeve to release the hair. Fingers adjacent the opening of the sleeve serve to cam the tines outwardly upon rotation in the opposite sense.
Patent IE-40598-L (IE)
Title: Piperidine derivatives
IPC: C08L67/00
Filed: 1975-02-12
Abstract: Compounds of the following general formula are useful as antihistamine agents, antiallergy agents and bronchodilators:
[US3946022A]
Patent IE-41407-L (IE)
Title: Prostanoic acid analogues
IPC: A61P43/00
Filed: 1975-02-14
Abstract: Novel analogues of prostanoic acids, which have the accompanying formula I, in which the symbols R1 to R3 have the meaning given in Patent Claim 1, are prepared by removing the tetrahydropyranyl ether protective group and the ketal grouping simultaneously or successively from an appropriately substituted 3-tetrahydropyranyloxy- 1,5-dioxaspiro compound. The corresponding compounds in which, instead of the keto group in the cyclopentyl radical, hydrogen and a hydroxy group are present, are obtained by reduction with a complex metal hydride. The compounds can then be converted into their physiologically tolerable salts or esters. The compounds are distinguished, even in the form of their epimer mixtures, by a good general spasmolytic, in particular bronchodilatory, action. They additionally have a hypotensive action and can also be employed in some cases in gastrointestinal disorders. <IMAGE>
[GB1507501A]
Patent IE-34079-L (IE)
Title: Catalytic epoxidation of olefins.
IPC: B01J23/00
Filed: 1970-04-01
Abstract: 1,248,185. Oxidation catalysts. SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ N.V. 1 April, 1970 [2 April, 1969], No. 15374/70. Heading B1E. [Also in Division C2] Catalysts for converting olefinic compounds to oxiame compounds by treatment with an organic hydroperoxide comprise an oxide of molybdenum and a solid support material consisting of oxides containing a major proportion of silica and/or alumina. The catalyst may contain bismuth oxide and/or one or more rare earth oxides. Suitable rare earth metal oxides are those of lanthanium, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium and lutebium. Commercial didymium (a complex mixture consisting mainly of oxides of lanthanum and neodymium) is particularly suitable.
[GB1248185A]
Patent IE-34283-L (IE)
Title: Sulphonamido-anthranilic acid derivatives
IPC: C07D213/65
Filed: 1970-04-07
Abstract: 1,260,155. Antihypertensive &c compositions. LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB. 17 April, 1970 [29 April, 1969], No. 21890/69. Heading A5B. [Also in Division C2] Pharmaceutical preparations, especially suitable for treating hypertension and oedemas contain I (including salts, esters and hydrates thereof) as active ingredient (A signifies R 4 O, R 4 S, R 4 SO or R 4 SO 2 , R 1 to R 4 are aliphatic, cycloaliphatic or aromatically, cycloaliphatically or heterocyclically substituted aliphatic radicals, R 1 to R 3 can also signify H, provided that when one or both of R 1 and R 2 are H or an aliphatic radical then A is not aliphatic R 4 O, R 3 and R 4 can also be aromatic or heterocyclic radicals and R 3 may also be acyl or optionally substituted carbamoyl). The preparations may also contain, hydralazin, methyldopa, reserpine, rescinnamine or protoveratrine and other Rauwolfia or Veratrum alkaloids and/or tranquilizers, e.g. meprobamate, and/or other diuretics and saluretics such as the benzothiadiazines, e.g. hydroflumethiazide or bendroflumethiazide; potassium-sparing compounds, e.g. triamterene or 3, 5-diamino-6-chloropyrazinoyl-guanidine, carboanhydrase inhibitors and aldosterone antagonists, e.g. spironolactone, may also be utilised. Administration may be orally, enterally or parenterally.
[GB1260155A]
Patent FI-820544-L (FI)
Inventor: FLORVALL GOESTA LENNART
IPC: A61P25/18
Filed: 1982-02-18
Abstract: Novel therapeutically active compounds of the formula   <IMAGE> I wherein R1 and R2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group or an acyl group, R3 is a lower alkyl group; an alkenyl group; or a benzyl group optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, A1 and A2 are the same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group, an alkoxycarbonyl group or a dialkylcarbamyl group, provided that when A1 and A2 are the same lower alkyl group and R3 is ethyl, R1 or R2 or both are selected among cyano, lower alkyl and acyl; or a physiologically acceptable salt or optical isomers thereof, methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.
Patent FI-843694-L (FI)
Inventor: SCHNEID JOSEF
IPC: F16C13/00
Filed: 1984-09-20
Abstract: The calender comprises a predetermined number of rolls and at least one of the rolls, for example, the outer roll or the lowest roll of such predetermined number of rolls is structured as a tubular roll or controlled deflection roll comprising a stationary roll support member or beam and a roll shell which rotates about the stationary roll support member and is supported thereat. A position sensor determines the position of the roll shell which is regulated with respect to predetermined reference values by a regulating device. A pre-selected number of different reference values for the position of the roll shell are provided and by selecting an appropriate one of these reference values there is achieved the result that different numbers of the predetermined number of rolls are operative while the remaining rolls of such predetermined number of rolls bear against related stops so that their related roll nips or gaps remain open.
Patent FI-854089-L (FI)
Inventor: WITHIAM MICHAEL C
IPC: C08K3/00
Filed: 1985-10-21
Abstract: 57 Alkaline earth metal alumino silicates of the formula:wherein Me is an alkaline earth metal, B is an alkali metal, and X is an integer of 1 to 3, are amorphous very high structure absorbents. The products are prepared by reaction of a reactive clay with an alkaline earth metal or hydroxide.
Patent IE-781000-L (IE)
Title: Ostomy composition
IPC: A61F5/443
Filed: 1978-05-18
Abstract: A composition adapted for use around the stoma consisting of a homogeneous mixture of a pressure sensitive adhesive component, mineral oil, and hydrocolloid gums or cohesive strengthening agents or a mixture of hydrocolloid gums and cohesive strengthening agents. By controlling the amount of mineral oil the resulting composition can be easily shaped according to the particular need.[US4166051A]
Patent IE-781071-L (IE)
Title: Pyridobenzodiazepinones
IPC: A61K31/00
Filed: 1978-05-29
Abstract: Compounds of the formula  wherein R1 is alkyl of 3 to 12 carbon atoms; unsaturated aliphatic hydrocarbyl of 3 to 20 carbon atoms comprising 1 to 3 double bonds and/or one triple bond; phenyl(alkyl of 2 to 4 carbon atoms); methylenedioxybenzyl; chlorobenzyl; indan-5-ylmethyl; indan-3-ylmethyl; phenyl(alkenyl of 2 to 4 carbon atoms); cycloalkyl of 5 to 7 carbon atoms; (cycloalkyl of 3 to 10 carbon atoms)methyl; (methylcycloalkyl of 4 to 11 carbon atoms)methyl; morpholino(alkyl of 2 to 3 carbon atoms); pyrrolidino(alkyl of 2 to 3 carbon atoms); piperidino (alkyl of 2 to 3 carbon atoms); 4-methylpiperazino(alkyl of 2 to 3 carbon atoms); or, when R3 and/or R4 are methyl or ethyl, also methyl or ethyl; R2 is hydrogen, methyl or ethyl; and R3 and R4 are each hydrogen, methyl or ethyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as anti-ulcerogenics and secretion inhibitors. (From US4213984 A) [FR2392993A1]
Patent IE-801192-L (IE)
Title: Bottle package
IPC: B65D71/50
Filed: 1980-06-10
Abstract: A highly stretched tubular sleeve 14 of resilient, elastic, biaxially oriented plastics material is positioned about an array of two or more bottles 12. The wall thickness of the sleeve is less than 0.004 inch (0.10 mm) and the unstretched circumferential dimension of the sleeve is at least 20% smaller than the maximum circumferential dimension of the array. The sleeve in unstretched condition has a distorted legend printed thereon, the distortion being removed when the sleeve is in position about the array of bottles. <IMAGE>
[GB2120197A]
Patent IE-811363-L (IE)
Title: Smoking article
IPC: A24D1/00
Filed: 1981-06-19
Abstract: Smoking articles, e.g. cigarettes, are disclosed into the fuel rod of which particulate smoke-modifying agent has been introduced in such a manner that the concentration of the agent is greater at one or each end of the fuel rod than that at the middle region of the fuel rod. The result of this variation in concentration of the smoke-modifying agent is that the amount of agent released into the smoke varies as the article is smoked. Various forms of smoking article are disclosed together with methods of production.
[US4434804A]
Patent IE-43794-L (IE)
Title: Pharmaceutical compositions
IPC: C07D217/02
Filed: 1976-06-25
Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.
[US4062961A]