Patent EA-004059-B1 (EA)
Title: 3-deoxy-desmycosin derivatives
Inventor: NARANDJA AMALIJA
IPC: C07D321/00
Filed: 2000-05-02
Abstract: 1. 3-deoxy-desmycosin derivatives of the formula I, wherein R represents CHO or CH(OCH3)2, R<1> and R<2> represent H or acetyl, R<3> represents H or OH, R<4> represents N(CH3)2 or N-O(CH3)2, the line --- represents a single or a double bond, the line ....... represents or a double or a single bond, and the line , provided that when A represents CH, , represents a double bond in position 2,3 and R<1> and R<2> are not acetyl. 2. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1> and R<2> represent acetyl, R<3> represents H, R<4> represents N(CH3)2, A represents a carbonyl group, the lines --- and ....... represent double bonds and the line represents a single bond. 3. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1> and R<3> represent H, R<2> represents acetyl, R<4> represents N(CH3)2, the lines --- and .... represent double bonds and the line represents a single bond. 4. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, the lines --- and represent double bonds and the line represents a single bond. 5. A compound according to claim 1 of the formula I, characterized in that R represents CHO, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, the lines --- and .... represent a double bond and the line represents a single bond. 6. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1> and R<2> represent acetyl, R<3> represents H, R<4> represents N(CH3)2, A represents a carbonyl group and the lines ---, .... and represent single bonds. 7. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1> and R<3> represent H, R<2> represents acetyl, R<4> represents N(CH3)2, and the lines ---, ... and represent single bonds. 8. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, and the lines ---, .... and represent single bonds. 9. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1> and R<2> represent acetyl, R<3> represents H, R<4> represents N-O(CH3)2, A represents a carbonyl group, the line --- represents a double bond, the line .... represents and the line represents a single bond. 10. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1> and R<3> represent H, R<2> represents acetyl, R<4> represents N-O(CH3)2, the line --- represents a double bond, the line ....... represents and the line represents a single bond. 11. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N-O(CH3)2, a represents a carbonyl group, the line ---- represents a double bond, the line .... represents and the line represents a single bond. 12. A compound according to claim 1 of the formula I, characterized in that R represents CH(OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, A represents a carbonyl group, the line --- represents a single bond, the line .... represents and the line represents a single bond. 13. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1> and R<3> represent H, R<2> represents acetyl, R<4> represents N(CH3)2, A represents a carbonyl group, the line --- represents a single bond, the line .... represents and the line represents a single bond. 14. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1> and R<2> represent H, R<3> represents OH, R<4> represents N (CH3)2, A represents a carbonyl group, the lines --- and ... represent single bonds and the line represents a double bond. 15. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N-O (CH3)2, A represents CH, the line --- represents a double bond, the line .... represents , and the line represents a single bond. 16. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1>, R<2> represent H, and R<3> represent OH, R<4> represents N(CH3)2, A represents CH, the lines --- and .... represent single bonds and the line represents a double bond. 17. A compound according to claim 1 of the formula I, characterized in that R represents CH (OCH3)2, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, and the lines ---, .... and represent single bonds in position 11, 12 and a double bond in position 2,3. 18. A compound according to claim 1 of the formula I, characterized in that R represents CHO, R<1>, R<2> and R<3> represent H, R<4> represents N(CH3)2, and the lines ---, .... and represent single bonds in position 11, 12 and a double bond in position 2,3.