baber/WOPTO huggingface dataset:
Patent CA-2506331-A1 (CA)
Title: Protein specific to pancreatic beta cells in islets of langerhans and applications thereof
Inventor: FAVIER ALAIN
IPC: C12Q1/68
Filed: 2003-11-18
Abstract: Isolated nucleic acid (I) comprises, or correspond to, a 1110 bp human sequence (1), reproduced, or its derivatives. Isolated nucleic acid (I) comprises, or correspond to: (i) a 1110 bp human sequence (1); (ii) a fragment of (1) containing at least 15 consecutive nucleotides (nt) other than the expressed sequence tags GenBank BM565129, BM310003, BM875526, BG655918, BQ417284, BQ267316, BU072134, BQ267526, BQ270198, BU581447, BU070173 and BQ631692; (iii) a sequence at least 80% identical with (i) or (ii), after optimal alignment; (iv) a sequence that hybridizes under stringent conditions with (i) or (ii); or (v) the complement, sense or antisense, of (i)-(iv). Independent claims are also included for: (1) probes for detecting, identifying or determining the corresponding nucleic acid in other organisms consisting of (I); (2) primers for amplification of the corresponding nucleic acid in other organisms consisting of (I); (3) polynucleotide (Ia) obtained by amplification with the primers of (2); (4) determining the transcription profile, or alteration in this, of the gene corresponding to (I); (5) method for detecting the gene corresponding to (I), its allelic variants and functional alterations in it; (6) reagent kit for methods (4) and (5); (7) DNA chip comprising at least one (I); (8) isolated protein (II) having a 369 amino acid sequence (2), reproduced, its analogs, fragments and variants, or any protein encoded by (I); (9) protein chip containing at least one (II); (10) cloning and/or expression vector containing (I); (11) cell transformed by at least one (I) or the vector of (10); (12) non-human transgenic organism in which at least some cells contain (I) or the vector of (10), in free or integrated form; (13) preparing (II) by culturing cells of (11) or organisms of (12); (14) protein (IIa) produced by method (13); (15) mono- or poly-clonal antibodies (Ab) that recognize (II) or (IIa) specifically; (16) protein chip containing at least one Ab; (17) kit for performing method (17); (18) selecting beta -cells of the islets of Langerhans using Ab; (19) monitoring differentiation of stem cells into pancreatic islet cells and beta -cells, using Ab; and (20) screening for (bio)chemicals that interact, in vitro or in vivo, directly or indirectly, with (I), (Ia), (II) or (IIa). ACTIVITY : Antidiabetic. No details of tests for antidiabetic activity are given. MECHANISM OF ACTION : Modulating activity or expression of the zinc transporter ZnT-8, implicated in maturation and exocytosis of insulin.
Patent CA-2508682-A1 (CA)
Title: Locking cross bar
Inventor: KONSTANT ANTHONY N
IPC: A47B47/00
Filed: 2005-05-30
Abstract: A cross bar forming a support surface between parallel deck beams of rack-type storage systems to create storage shelves, the cross bars being lockable and readily removable and reusable.
Patent CA-2509088-A1 (CA)
Inventor: DE BOECK BENOIT CHRISTIAN ALBE
IPC: C07D401/14
Filed: 2003-12-17
Abstract: La présente invention concerne des dérivés 1-pipéridin-3-yl-4-pipéridin-4-yl-pipérazine substituée présentant une activité antagoniste envers la neurokinine, notamment une activité antagoniste NK¿1?, une activité antagoniste combinée NK¿1?/NK¿3? et une activité antagoniste combinée NK¿1?/NK¿2?/NK¿3, ?la préparation de ces dérivés, des compositions renfermant ces dérivés et leur utilisation en tant que médicament, notamment pour le traitement de la schizophrénie, des vomissements, de l'anxiété et de la dépression, du syndrome du colon irritable, des perturbations du rythme circadien, des douleurs viscérales, de l'inflammation neuropathique, de l'asthme, des troubles de la miction tels que l'incontinence urinaire et la nociception. Les composés selon l'invention peuvent être représentés par la formule (I) et l'invention concerne également les sels d'addition basique ou acide pharmaceutiquement acceptables de ces derniers, les formes stéréochimiquement isomères de ces derniers, la forme <I>N-</I>oxyde et les précurseurs de médicaments de ces derniers, dans lesquels tous les substituants sont tels que définis dans la revendication numéro 1. Du fait de leur capacité à jouer un rôle antagoniste contre les effets des tachykinines par le blocage des récepteurs de neurokinine et notamment par leur action antagoniste contre les effets de la substance P, et de la Neurokinine A et de la Neurokinine B par le blocage des récepteurs NK¿1?, NK¿2? et NK¿3?, les composés selon l'invention sont utiles en tant que médicament, notamment dans le traitement prophylactique et thérapeutique des états induits par la tachykinine, tels que, par exemple, les troubles du système nerveux central, plus particulièrement les troubles schizo-affectifs, la dépression, les troubles de l'anxiété, les troubles liés au stress, les troubles du sommeil, les troubles de la connaissance, les troubles de la personnalité, les troubles de l'alimentation, les maladies neurodégénératives, les troubles de l'addiction, les troubles de l'humeur, les dysfonctionnements sexuels, la douleur et d'autres états liés au système nerveux central; les inflammations; les troubles allergiques; les vomissements; les troubles gastro-intestinaux, notamment le syndrome du côlon irritable; les troubles cutanés; les maladies vasospastiques; les maladies fibrosantes et liées au collagène; les troubles liés à l'augmentation ou à la diminution de la réponse immunitaire et les maladies rhumatismales ainsi que le contrôle de la masse corporelle.Formule (I)
Patent CA-2512485-A1 (CA)
Title: Tool for measuring perforation tunnel depth
Inventor: BROOKS JAMES E
IPC: E21B47/047
Filed: 2005-07-19
Abstract: Various systems and methods are disclosed herein for determining the depth of a cavity in a wellbore using the Helmholtz Effect.
Patent CA-2515035-A1 (CA)
Inventor: GERMAIN FRANTZ
IPC: H02H3/33
Filed: 2004-01-30
Abstract: A GFCI device (10) which has reverse wiring protection is provided where no power is present at the face terminals (32, 34) even when the device is reversed wired. The device has a pair of movable bridges connected to its terminals. The terminal bridge pair makes contact with the load and the face terminals (32, 34) providing power to these terminals when the device is reset. The device also has a reset lockout feature that prevents it from being reset after having been tripped if the circuit interrupting portion of the device is non-operational.
Patent CA-2517596-A1 (CA)
Title: Vapour diffusing device
Inventor: MCGEE THOMAS
IPC: A01M29/12
Filed: 2004-02-26
Abstract: A device adapted to provide volatile liquid material to an atmosphere comprising a reservoir (1) containing volatile liquid material, a rod-like transfer member (3, 4) extending therefrom and adapted to transfer liquid from the reservoir, and at least one diffusion surface (7) adapted to receive the liquid from the transfer member and facilitate its evaporation into the atmosphere, the diffusion surface extending essentially laterally from the transfer member and comprising at least one non-integral, non-porous sheet bearing a surface capillarity (9), which sheet has an extent and a capillarity sufficient to allow an appropriate evaporation. The device is cheap and easy to construct, versatile and diffuses odour without major changes of the odour over time.
Patent CA-2518899-A1 (CA)
Inventor: SCHOENDORFER DON
IPC: A61M1/26
Filed: 2004-03-10
Abstract: Preferred aspects of the present invention relate to a device (10) for filtration comprising at least one rotor (14) configured to create Taylor vortices on at least one side of a filtration membrane (18), thereby providing substantially enhanced mass or heat transfer across the membrane (18).
Patent CA-2519599-A1 (CA)
Title: Laser modification
Inventor: HOLLANDER MILTON BERNARD
IPC: G01J5/02
Filed: 2005-09-12
Abstract: A method and device are described for controlling and/or attenuating aiming laser beam brightness in a hand held radiometer.      The beam from the laser is directed at a target measurement surface and a transversely movable element member is interposed between the laser and the target to change the beam brightness on the target.      In a preferred device a slidable or rotatable element intercepts the beam between the laser and target and a calibrated opening in the element of selected size and/or shape allows part of the beam to pass through the element to provide a safe brightness at the target.
Patent CA-2519856-A1 (CA)
Title: Chocolate fountain apparatus with output port
Inventor: ESNAULT MICHEL
IPC: B05B17/08
Filed: 2005-09-15
Abstract: A fountain apparatus for use with a flowable food media includes a recipient for receiving the food media therein and an output port. The recipient is heatable within a predetermined temperature range for maintaining the food media within the temperature range. The output port connects to the recipient and has a passageway extending there through for receiving the food media. The passageway defines an inlet opening that is in fluid communication with the recipient and an outlet opening that has an opening mechanism to selectively control the opening thereof. A heating member is thermally connected to the output port for warming up the same to maintain the food media therein within the temperature range.
Patent CA-2520826-A1 (CA)
Title: Led light bar assembly
Inventor: BEAUCHAMP PIERRE J
IPC: F21S4/28
Filed: 2005-09-23
Abstract: An LED (light emitting diode) light bar assembly is comprised of an elongated casing having an elongated cavity of substantially U-shape cross-section. The casing has a base wall, opposed side walls and an elongated open end between the side walls. One or more elongated heat sink LED modules each having two or more LEDs and electrical component parts thereof are retained in each of the modules.      The LEDs are exposed in a spaced-apart relationship in a common wall of the modules. The casing is configured to removably receive and retain one or more of the modules therein in end-to-end relationship. The casing defines in combination with the one or more modules, at least one internal channel for the passage of wiring which is non-visible exteriorly of the module. At least one end connector is detachably securable to an end of the casing for securing the casing to a support structure. The connector has an internal passage for receiving wiring from the modules retained in the casing.
Patent CA-2521486-A1 (CA)
Inventor: HASHEMI BRIAN
IPC: G01N33/569
Filed: 2004-04-02
Abstract: The present invention relates to the analysis of cells, their cytoskeletal protein, and uses thereof. More particularly, the present invention relates to methods of analyzing cytoskeletal protein for a range of applications including, methods of measuring cellular responses and methods of identifying biomolecular signatures.
Patent CA-2529835-A1 (CA)
Title: Adjustable tool station
Inventor: WIXEY BARRY D
IPC: B27B5/16
Filed: 1995-01-13
Abstract: An adjustable tool station is disclosed which includes a subframe, a table portion rotatably attached to the subframe, wherein the table portion includes an upper surface defining a work support plane, a tool mounted to the table portion, and a fence fixed to the subframe and extending above the work support plane, wherein the fence includes a first side and a second, opposite side. The first side constitutes a workpiece guide surface, and defines a workpiece guide area which includes all points which are closer to the first side than the second side. All portions of the subframe located within the workpiece guide area are located below the work support plane.
Patent CA-2531031-A1 (CA)
Title: Subsea compressor module and a method for controlling the pressure in such a subsea compressor module
Inventor: STINESSEN KJELL OLAV
IPC: F04D25/06
Filed: 2004-07-01
Abstract: A subsea gas compressor module having a housing comprising a sealing element (14) generally defining within said pressure housing at first compartment holding as compressor (2) and a second compartment holding an electric motor (1), said compressor and motor being driveably connected by at least one shaft (13). The first compartment is connected to an inlet line (11) and an outlet line for sealing hydro carbon gas and for discharging gas. The second compartment comprises magnetic bearings (12) for supporting said at least one shaft, and a pressure and volume regulator io is fluidly connected to said second department and a gas supply (5; 11) of gas, and comprises means for sense in respective pressures in the inlet and outlet lines were by, based on a magnitude of said sense pressure, the pressure and volume regulator controls the pressure at which gas is injected into said second compartment. The subsea gas compressor module is for ever characterised in that at least one shaft is supported by is magnetic bearings controlled by control unit (16), where the bearings and control unit are placed in at least one pressure housing comprising a fluid having a controlled pressure, whereby said bearing and control unit are protected from the ingress of the sea water.
Patent CA-2531728-A1 (CA)
Inventor: HONEYMAN LAURA
IPC: C07C275/28
Filed: 2004-06-25
Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
Patent CA-2531945-A1 (CA)
Inventor: BUELTER CHRISTOPH
IPC: F16K27/00
Filed: 2006-01-04
Abstract: A distributor for liquids has a base me tuber having an intake and at least two outlets. At least one branch member is connected to one of the at least two outlets in a position that is changeable relative to the base member. The at least one branch member has an outlet opening. A distributor kit has a distributor, a closure element for closing one of the at least two outlets of the base member of the distributor, and branch elements for each one the outlets that is not closed off by the closure element.
Patent CA-2533000-A1 (CA)
Inventor: RODRIAN JAMES A
IPC: B67D7/08
Filed: 2006-01-16
Abstract: Automatic dispensers, proximity detectors and user-detection methods. A proximity detector can be used to trigger operation of the dispenser to dispense products such as towel, tissue, wipes, sheet-form materials, soap, shaving cream, fragrances and personal care products.
Patent CA-2536237-A1 (CA)
Inventor: HILL JOHN L III
IPC: E21B10/44
Filed: 2004-08-18
Abstract: A helical drag bit provided with spirally/helically positioned cutting arms. The arms can create a spiral trench geometry in the sidewall of a predrilled pilot hole. The cutting arms can terminate in scoring cutting blades. The helical drag bit can be incorporated into a system and method for measuring geo-tech characteristics. The helical drag bit can be used in a system and method for improving the holding capacity of rock bolts and similar devices for use in the mining industry or in any circumstances where a particulate substrate may benefit from support. Novel rock bolts having new structures can be used with this improved hole geometry or may form such improved hole geometry.
Patent CA-2536274-A1 (CA)
Title: Resealable nurser liner
Inventor: KNUTH ROSEMARY F
IPC: A61J9/00
Filed: 2004-08-19
Abstract: There is provided a nurser liner (10) having a closure member (200) for selectively sealing the liner. The closure member has a size and shape that facilitates engagement with the open upper end of a holder (300).
Patent CA-2536554-A1 (CA)
Inventor: IMLER DAVID L
IPC: F16L37/56
Filed: 2006-02-14
Abstract: A breakaway coupling for a fuel supply hose includes a male tubular valve body interfitting with or female tubular valve body and defining a fuel supply passage, and the valve bodies enclose axially moveable spring biased valve members. The valve bodies are connected by releasable connecting means which provide for moving the valve bodies from a connected position to a disconnected position in response to a substantial axial tension force on the valve bodies. The valve bodies have cooperating peripherally extending and opposing cam surfaces effective to move the valve bodies from the connected position to the disconnected position in response to relative rotation of the valve bodies and cam surfaces. The valve bodies may also define a vapor return passage with an axially movable valve member and disposed either radially outboard or inboard of the fuel supply passage.
Patent CA-2536996-A1 (CA)
Title: Drinking vessel megaphone
Inventor: BAKTI TYRONE T
IPC: G10K11/02
Filed: 2006-02-21
Abstract: The present invention provides a novel mug that includes a vessel portion and a megaphone portion. The vessel portion is essentially suspended in the megaphone portion by attachment at the drinking rim.
Patent CA-2537254-A1 (CA)
Inventor: STAUDT LOUIS M
IPC: G16B40/20
Filed: 2004-09-03
Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing iymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
Patent CA-2538619-A1 (CA)
Inventor: FOSTER KEITH
IPC: A61K47/48
Filed: 2004-09-13
Abstract: The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties, to re-target a toxin to a cell of therapeutic interest. In particular, the present invention describes a method for designing a toxin conjugate, and describes therapeutic applications of said conjugates to inhibit or reduce cellular processes. Even more particularly, the present invention describes a method for designing toxin conjugates based upon non- cytotoxic toxins able to inhibit exocytosis, such as clostridial neurotoxins, and describes therapeutic applications of said conjugates to inhibit or reduce exocytosis (for example secretion, or the delivery of proteins such as receptors, transporters, and membrane channels to the plasma membrane of a cell).
Patent CA-2539236-A1 (CA)
Title: Office chair
Inventor: HENDRICK POTAPPEL WILLEM
IPC: B62K5/003
Filed: 2006-03-10
Abstract: An office chair includes a base and a height adjustable seat mounted to the base and having a front end. The base includes a pair of centrally positioned, laterally spaced apart drive wheels that are manually operated by a user or which are motorized.
Patent CA-2541473-A1 (CA)
Inventor: SKLAN ELLA
IPC: C12Q1/46
Filed: 2004-10-10
Abstract: The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.
Patent CA-2541540-A1 (CA)
Title: Para-xylene process using perm-selective separations
Inventor: MILLER JEFFREY T
IPC: C07C15/08
Filed: 2004-07-15
Abstract: Processes and apparatus are disclosed for recovery of purified products from a fluid mixture by means of integrated perm-~selective separations with purified product recovery operations. More particularly, integrated processes of the invention comprise separations by means of one or more devices using polymeric membranes coupled with recovery of purified products by means of fractional crystallization and/or selective sorption. Processes of the invention are particularly useful for recovery of a very pure aromatic isomer when processing aromatic starting materials, for example, a pure para-xylene product from liquid mixtures even containing ethylbenzene as well as the three xylene isomers.
Patent CA-2543177-A1 (CA)
Title: Compositions and dosage forms for enhanced absorption of metformin
Inventor: WONG PATRICK S L
IPC: A61K9/24
Filed: 2004-10-29
Abstract: A complex comprised of metformin and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of the drug through a period of ten to twenty-four hours, thus enabling a once-daily dosage form for metformin.
Patent CA-2544410-A1 (CA)
Inventor: HATT ROLF
IPC: D06F58/00
Filed: 2004-01-19
Abstract: The invention relates to a device ( 1 ) which is used to store and dry sports equipment. Said device comprises two vertical supports ( 2 ) which are connected together in a communicating manner by means of a transversal carrier ( 3 ). Several tubular elements ( 12, 13, 18, 20 ) are strapped to the two vertical supports ( 2 ) which also communicate therewith. The above-mentioned tubular elements comprise air outlets ( 30 ). Air is blown through said air outlets ( 30 ), said air being introduced into the communicating tubes by means of a ventilator ( 31 ). A flange element ( 32 ), which is embodied in the form of a T in the transversal carrier ( 3 ) is used in order to mount the ventilator ( 31 ). The individual tubular elements are formed in such a manner that they can be adapted, in a particularly precise manner, to the various elements of sports equipment.
Patent CA-2544874-A1 (CA)
Title: Rouge free pharmaceutical water for injection (wfi) water system
Inventor: LIVINGSTON ROBERT C
IPC: C02F1/20
Filed: 2004-09-20
Abstract: The present invention relates to rouge (corrosion) free pharmaceutical Water for Injection (WFI) systems. These systems are usually made of 316 stainless steel. Rouge is prevented by using a controlled atmosphere which does not contain carbon dioxide. Preferably, this controlled atmosphere is a mixture of about 80% nitrogen and about 20% oxygen.
Patent CA-2546381-A1 (CA)
Title: Use of bis-amines to enhance the antimicrobial activity of aqueous compositions
Inventor: MEADOWS DAVID L
IPC: A01N33/04
Filed: 2004-12-09
Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are of general formula (I):   (see formula I) wherein R1, R2, R3, R4, R5 and R6 are as described, herein. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.