baber/WOPTO huggingface dataset:
Patent BG-64388-B1 (BG)
Title: Water soluble azoles as broad-spectrum antifungals
Inventor: MEERPOEL LIEVEN
IPC: A61K31/495
Filed: 2000-08-28
Abstract: The present invention concerns novel compounds of formula the N-oxide forms, the pharmaceutically acceptable salts and stereochemically isometyric forms thereof, wherein L represents a radical of formulae or wherein each Alk independently represents an optionally substituted C1-6alkanediyl; n is 1, 2 or 3; Y is O, S or NR2; R1 represents aryl, Het1, or an optionally substituted C1-6alkyl; R2 represents hydrogen; or in case R1 and R2 are attached to the same nitrogen atom, they may be taken together to form a heterocyclic radical; or they may be taken together to form an azido radical; each R3independently represents hydrogen, hydroxy or C1-4alkyly; aryl represents phenyl, naphthalenyl, 1,2,3,4-tetrahydronaphthalenyl, indenyl or indanyl; each of said aryl groups may optionally be substituted; Het1 represents an optionally substituted monocyclic or bicyclic heterocyclic radical; Het2 is the same as Het1 an d may also be piperazinyl, homopiperazinyl, 1,4-dioxanyl, morphonlinyl, thiomorpholinyl; R6 represents hydrogen or C 1-4alkyl; R7 represents hydrogen or C1-4alkyl; or R6 and R7 taken together form a bivalent radical of formula -N=CH-(i), -CH=N-(ii), -CH=CH-(iii), -CH2-CH2(iv), wherein one hydrogen atom in the radicals (I) and (ii) may be replaced with a C-4alkyl radical and one or more hydrogen atoms in radicals (iii) and (iv) may be replaced by a C1-4alkyl radical, and D represents a trisubstituted tetrahydrofuran derivative; as antifungals; their processes for preparation, compositions containing them and their use as a medicine.
Patent BG-65151-B1 (BG)
Title: Use of 4-h-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation
Inventor: PATTERSON WINSTON CAMPBELL
IPC: A61P21/00
Filed: 2001-07-27
Abstract: Smooth muscle cells (SMC) proliferation is a critical component of neointimal formation in many animal models of vascular injury, and in many human lesions as well. Cell cycle inhibition by gene transfer techniques can block SMC proliferation and lesion formation in many animal models, although these methods are not yet applicable to the treatment of human disease. The invention relates to the effects of flavopiridol, a recently identified cyclin-dependent kinase inhibitor on CMC growth in vitro and in vivo. Flavopiridol (75 nmol/L) potently blocked SMC proliferation, an effect that was associated with downregulation of cyclin-dependent kinase activity and cell cycle-related gene expression. The invention also relates to the effects of flavopiridol on the CMC proliferation in vivo in the rat carotid injury model. Flavopiridol (5 mg/kg) decreased neointimal size by 35 % and 39% at 7 and 14 days, respectively, after balloon injury. Flavopiradol may be a potential therapeutic tool in the treatment of SMC-rich vascular lesions. 4-H-1-benzopyran-4-one derivatives with general formula inhibit smooth muscle cell proliferation at low dosage levels.
Patent BG-65348-B1 (BG)
Title: Eye-prosthesis and method for its fabrication
Inventor: BALKANSKI EMIL
IPC: A61F2/00
Filed: 2003-08-18
Abstract: The prosthesis and the method of its fabrication find application in the maxillofacial surgery for making cosmetic-physiological substitute of impaired organs of sight of living organisms - men and animals. The prosthesis has multilayer, relief and 3-dimensional image of the iris of individual, unique implementation, different for each individual patient, with improved precision of the form. One gets the impression that its diameter is changing at different lighting, as is with the healthy eye, and further on certain imitation effect is created for the presence of red gleam in the pupil, thuse liminating the unfavourable photographic effect in photographing using a flashlight. By the method the eye prosthesis is fabricated with improved precision after taking an imprint by means of a plastic model of the residual muscle mass of the impaired eye. After the surgical intervention performed, maximum mobility is ensured of the remaining muscle tissue in the eyeball of the impaired eye and the mobility of the prosthesis is ensured. Optimum contact is established between the eye prosthesis and the existing muscle tissue in the eyeball of the impaired eye. The prosthesis comprises sclera on which blood vessels, iris and pupil are formed which are made as a multilayer 3-dimensional body. The pupil is fitted in the iris in a changeable horizontal plane and is coloured by a reflection on the red spectrum of the light spectrum.
Patent BG-66583-B1 (BG)
Title: Micro tape short antenna with back radiation with circular polarization
Inventor: KIROV GEORGI
IPC: H01Q19/185
Filed: 2011-12-06
Abstract: Invention relates to the design of micro tape short antenna with back radiation with circular polarization, which can be used separately and as a component in multi element antenna arrays in communication, radio navigation, radiolocation and radio and television equipment in the UHF and centimeter ranges. It is a compact antenna structure with good electrical and mechanical properties. It consists of a rectangular metallic radiating element (1), five circular dielectric pads (2, 6, 8, 9, 12), the general round metal base (3) with a cross-shaped cut out in it crevice (4), a peripheral cylindrical metal screen ( 5), a small rectangular metal reflector (7), round metal screen (13) and excitation micro tape line connected to the coaxial connector. The presence of two resonances in the impedance characteristic of antenna and impedance coordination between dielectric pads and free space leads to expansion of the impedance bandwidth, and by an appropriate choice of the size of crevice, radiating element and the small reflector, achieves expansion of polarization bandwidth. The antenna structure is compact and high mechanical strength due to the absence therein of air gaps, and dielectric materials with lower mechanical properties.
Patent CH-714207-B1 (CH)
Title: Vorrichtung zum Entmagnetisieren lang ausgestalteter Bauteile und Verfahren zur Entmagnetisierung solcher Bauteile.
Inventor: DR SC TECH URS B MEYER
IPC: H01F13/00
Filed: 2018-09-14
Abstract: Die Erfindung betrifft eine Vorrichtung (1) zum Entmagnetisieren eines ferromagnetischen, lang ausgestalteten Bauteils (2) beliebiger Länge mit gleichförmigem Profil, das einseitig entlang seiner Länge eine zugängliche Oberfläche (6) aufweist. Die Vorrichtung (1) umfasst einen stabförmigen, ferromagnetischen Kern (7) mit einer umlaufenden Mantelfläche (8), welche von einer vorderen Stirnfläche (9) und einer hinteren Stirnfläche (10) abgeschlossen wird, wobei diese Stirnflächen (9, 10) voneinander abgewandt ausgerichtet sind. Um die Mantelfläche (8) ist mindestens eine Spule (12) gewickelt, welche mit einer Stromquelle (15) verbunden ist, die einen Wechselstrom (AC) erzeugen kann, wodurch ein Magnetwechselfluss (18) in den ferromagnetischen Kern (7) induziert wird, der an den beiden Stirnflächen (9, 10) ein- und austritt. Erfindungsgemäss ist eine Spule (12, 13) um die Mantelfläche (8) des ferromagnetischen Kerns (7) gewickelt, welche mit einer Stromquelle (15, 16) verbunden ist, die einen Gleichstrom (DC) erzeugen kann, zum Überlagern des Magnetwechselflusses (18) mit einem dadurch induzierten gleichförmigen Magnetgleichfluss (19) durch den ferromagnetischen Kern (7), der an den beiden Stirnflächen (9, 10) ein- resp. austritt. Beim erfindungsgemässen Verfahren zum Entmagnetisieren eines solchen Bauteils (2) fährt der ferromagnetische Kern (7) mit gleichbleibendem Abstand a das Bauteil ab, während der Magnetwechselfluss (18) und der Magnetgleichfluss (19) konstant gehalten werden.
Patent CH-716775-B1 (CH)
Title: Aufzug, insbesondere ein Person- und / oder Warenaufzug.
Inventor: DANIEL TÜRLER
IPC: B66B7/02
Filed: 2019-11-07
Abstract: Ein Aufzug, insbesondere ein Personen- und/oder Warenaufzug, umfasst eine verfahrbare Kabine und vorzugsweise ein mit dieser verbundenes Gegengewicht (4), die in Längsführungen (6, 7) gleitende Führungselemente (9a) aufweisen, welche in einem Liftschacht in Fahrtrichtung der Kabine verlaufend befestigbar sind. Diese Längsführungen (6, 7) sind zumindest für die Kabine durch Blechprofilschienen (11) mit jeweils einem U-förmigen Querschnitt gebildet, die jeweils vorstehende Schenkel (13, 14) mit Gleitflächen (13a, 13b, 13c) für die Führungselemente (9a) der Kabine aufweisen. Vorzugsweise ist der eine vorstehende Schenkel (13) der jeweiligen Blechprofilschiene (11) mit einem abgewinkelten Schienenteil (15) für die Führung des Gegengewichtes (4) und der andere vorstehende Schenkel (14) der Blechprofilschiene (11) mit einem abgewinkelten Schienenteil (16) für den Eingriff in einer Fangvorrichtung (17) für die Kabineversehen. Damit wird nebst der einfachen Ausführung eine sehr steife und absolut laufruhige Führung der Kabine ermöglicht.
Patent CH-705475-B1 (CH)
Title: Verfahren zum Auftragen von Klebstoff auf ein Substrat.
Inventor: STALDER ROLAND
IPC: H05K13/04
Filed: 2011-09-09
Abstract: Das erfindungsgemässe Verfahren betrifft das Auftragen von Klebstoff auf ein Substrat (1), bei dem die mit Klebstoff zu versehenden Substratplätze (5) entlang von parallel verlaufenden, geraden Linien (6) angeordnet sind, wobei jede Linie (6) eine vorbestimmte Anzahl n von Substratplätzen (5) enthält, denen die Nummern 1 bis n zugeordnet sind. Es wird Linie (6) um Linie (6) abgearbeitet, um Klebstoff auf die Substratplätze (5) einer Linie (6) aufzutragen. Das Auftragen von Klebstoff auf die Substratplätze (5) einer Linie (6), denen die Nummern k=m+1 bis k=n–m–1 zugeordnet sind, wobei m eine Ganzzahl ist, erfolgt gemäss den folgenden Schritten: Bewegen der Dispensdüse (2) vom Substratplatz (5) mit der Nummer k–1 in eine Position, in der sich die Dispensdüse (2) an ihrer Startposition über dem Substratplatz (5) mit der Nummer k befindet, und sofern erforderlich, Bewegen der Kamera an eine Position, in der zumindest die drei Substratplätze (5) mit den Nummern k–m, k und k+m im Blickfeld (4) der Kamera sind, Aufnehmen eines Bildes und überprüfen, ob der auf dem Substratplatz (5) mit der Nummer k–m aufgetragene Klebstoff die gestellten Anforderungen erfüllt, und Ermitteln der Lage des Substratplatzes (5) mit der Nummer k+m, und Auftragen von Klebstoff auf den Substratplatz (5) mit der Nummer k.
Patent CH-708553-B1 (CH)
Title: Mobile horloger à rattrapage de jeu.
Inventor: FRÉDÉRIC MAIER
IPC: G04B35/00
Filed: 2013-09-03
Abstract: L’invention concerne un mobile horloger à rattrapage de jeu constitué par un ensemble monobloc comprenant un moyeu (1.2, 2.2), une première serge dentée (1.1) reliée de façon rigide au moyeu (1.2, 2.2) et une seconde serge dentée (2.1) reliée au moyeu (1.2, 2.2) par au moins un second bras déformable élastiquement (2.3) permettant un déplacement angulaire de la seconde serge (2.1) par rapport à la première serge (1.1).
Patent CH-714461-B1 (CH)
Title: Fermoir pour bracelet avec mise à l'aise.
Inventor: ALEXIS VILLER
IPC: A44C5/24
Filed: 2017-12-19
Abstract: L'invention se rapporte à un fermoir (1) pour bracelet comprenant au moins des première et deuxième lames (2, 3), la première lame (2) étant articulée à la deuxième lame (3) par une première extrémité, entre une position fermée, dite position de porter, dans laquelle la deuxième lame (3) est repliée sur la première lame (2), et une position ouverte dans laquelle la deuxième lame est dégagée de la première lame, la deuxième lame (3) portant à une seconde extrémité un organe de fixation pour un premier brin de bracelet, la première lame (2) étant apte à être reliée indirectement à un second brin de bracelet, le fermoir (1) comprenant en outre : des moyens de verrouillage aptes à maintenir la première lame dans sa position fermée, des moyens de réglage de la longueur utile du bracelet, les moyens de réglage comprenant un capot (6) monté sur une plaque de base (7) assujettie à la seconde extrémité de la deuxième lame (3), et ledit organe de fixation pour le premier brin de bracelet étant apte à coulisser entre le capot (6) et la plaque de base (7), Selon l'invention, l'organe de fixation est monté mobile et coulissant suivant une direction longitudinale du fermoir entre au moins une première position, vers au moins une seconde position dans laquelle l'organe de fixation est dégagé du capot du fermoir en exerçant une pression sur le capot selon une direction perpendiculaire au fermoir pour le faire coulisser, et en ce que l'organe de fixation comprend au moins un premier cran et un deuxième cran, l'organe de fixation étant agencé pour passer d'une première position dans laquelle le premier cran est en prise avec un pion solidaire de la plaque base, à une seconde position dans laquelle le deuxième cran est en prise avec ledit pion.
Patent EP-1030536-B1 (EP)
Inventor: SCHILLING WILFRIED
IPC: H05B3/74
Filed: 2000-01-24
Granted: 2003-11-12
Abstract: The touch-control switch has a sensor element (11) with a sensor surface (12) provided by a flat material extending acros the top of a housing (22) for a light display (23), provided with a cut-out corresponding in shape to the light display. A elastic conductive contact plate (13) can be inserted between the sensor surface and the underside of an overlying cover plate (16), e.g. a hob surface.
Patent EP-1053858-B1 (EP)
Inventor: KUEPPER RUDOLF
IPC: B29C49/04
Filed: 2000-03-24
Granted: 2006-08-02
Abstract: Continuous or non-continuous extrusion or coextrusion of a preform (6) is performed simultaneously with, but separate from, preform suction blowing stage to increase efficiency. An Independent claim is made for the process equipment which comprises a two part tool(8) with slides(24,25) closing the ca ends and an extrusion head(2) from preforms are removed and fed to the molding cavity(20) by a tube feeder(10).
Patent EP-1164091-B1 (EP)
Inventor: HOMER STEPHAN
IPC: B32B5/18
Filed: 2000-07-14
Granted: 2004-12-29
Abstract: Deep-drawn packaging tray comprises a sandwich of absorbent inner layer (I), firmly bonded between liquid-impermeable bottom and top outer layers (IIA, IIB). Top layer (IIB) is perforated so liquid can pass into layer (I). All layers are based on styrene polymers. Layers (II) consist of closed-cell foam foil and layer (I) consists of foam foil with (partly) open cells. The boundary between layers (II) and layer (I) is cellular and densified to the density of layer (II). Independent claims are also included for: (a) the production of the (partly) open cell foam foil for this tray; and (b) the production of deep-drawn packaging trays from a laminate with the (partly) open-cell foam foil.
Patent EP-1092524-B1 (EP)
Inventor: HERBST RICHARD
IPC: B29C45/14
Filed: 2000-09-25
Granted: 2003-11-26
Abstract: Handling system for injection molding machine, comprises, an arm (19) which extracts moldings (14) from the tool cavities in a first plane (43) and moves in this plane. A conveying unit in a second plane (28) removes the extracted moldings and a transfer station (40) moves the moldings between the two planes. Handling system for injection molding machine, comprises, an arm (19) which extracts moldings (14) from the tool cavities in a first plane (43) and moves in this plane. A conveying unit in a second plane (28) removes the extracted moldings and a transfer station (40) moves the moldings between the two planes. The transfer station has a molding transfer plate (41) which moves along a given path (53) from one position in the first plane to another position in the second plane, the path lying outside the first plane.
Patent EP-1086694-B1 (EP)
Inventor: LOPEZ CABRERA ANTONIO
IPC: A61K9/20
Filed: 2000-09-13
Granted: 2006-08-02
Abstract: The pharmaceutical formulation consists of a number of pellets that comprise an inert nucleus, a layer with the active ingredient, one or more intermediate layers that comprise at least a system of modified release, and an external layer of enteric coating. These pellets can be obtained applying the different layers by means of fluid bed coaling techniques using aqueous solutions or suspensions of the components of such layers. The pharmaceutical formulations can be hard gelatin capsules or tablets and are suitable for use in the prevention and treatment of disorders related to abnormal gastric acid secretion.
Patent EP-1067093-B1 (EP)
Inventor: BELLIS D
IPC: C01C1/24
Filed: 2000-07-07
Granted: 2004-12-15
Abstract: A new method for the preparation of granular ammonium sulphate that is free-flowing and does not clump, with a minimum title of 20.5% and a granular composition and hardness similar to common granular fertilisers.  The method is characterised by the combined use of the classic reaction tank and the tubular reactor (without excluding the use of either element alone). It uses sulphuric acid, liquid or gaseous ammonia and the water from the washing of the tail gases from the reaction. The liquor produced in the reaction tank and in the tubular reactor is of temperature, pressure, humidity, concentration and pH such that upon entering the granulator it is transformed into granules of the desired size and hardness. The proper feeding distribution of raw materials and water at both stages of production is an important factor in the success of the method.  The method is used for the rapid production, with minimal impact on the environment, of a fertiliser with good quality characteristics. <IMAGE>   <IMAGE>
Patent EP-1147077-B1 (EP)
Title: Method for preparing azoiminoethers
Inventor: BOURDAUDUCQ PAUL
IPC: C07C257/06
Filed: 2000-01-07
Granted: 2008-07-23
Abstract: The invention concerns a method for preparing an azoiminoether hydrochloride which consists in reacting an azonitrile with an alcohol and hydrochloric acid in an aromatic solvent, wherein the molar ratio R=HCl/azonitrile is >2 when the alcohol is methanol and >3 when the alcohol is ethanol or a higher alcohol. The invention also concerns a method for preparing an azocarboxylic acid ester which consists in the synthesis of an azoiminoether hydrochloride by the inventive method and, hydrolysis in the presence of the resulting azoiminoether hydrochloride. Said methods enable to obtain liquid composition of azocarboxylic acid esters. The invention further concerns mixed azoiminoether salts of formula (II'). The invention also concerns mixed azoiminocarboxylic acid esters corresponding to the formula (III').
Patent EP-1154700-B1 (EP)
Inventor: HUSS MANFRED
IPC: A23C21/00
Filed: 2000-02-06
Granted: 2003-05-07
Abstract: The invention relates to a method for preparing a concentrate of denatured whey protein aggregate preferably having a mean aggregate size (median) of between 1 and 4 mum. Said method consists of the following steps: a) an aqueous solution enriched to a maximum protein content of 4% by weight, containing whey protein and having a pH of between 5.0 and 7.0 is thermally denatured to [<=80%] <=90%, in relation to the protein content, under substantially non-shear conditions at a temperature of between 75 and 150° C. and by means of a holding period; and b) the resulting product is concentrated, preferably to a denatured whey protein concentration of between 5 and 20%.
Patent EP-1151568-B1 (EP)
Inventor: LEISCHING PATRICK
IPC: H04J14/02
Filed: 2000-02-08
Granted: 2006-05-03
Abstract: L'invention concerne une configuration dans laquelle les fonctions d'insertion-extraction sont réparties dans deux modules, ce qui permet le remplacement d'un des modules sans interruption des liaisons.
Patent EP-1177061-B1 (EP)
Inventor: GILL JEFFREY STEVEN
IPC: B23B47/04
Filed: 2000-03-08
Granted: 2006-06-21
Abstract: The present invention is a low profile self-adhering drill having a feed mechanism having an axis of rotation, which is generally perpendicular to the axis of rotation of the drill motor. The feed mechanism includes a quill housing which houses a quill. A spindle is disposed within the quill for holding the tool. The spindle is in engagement with the quill and rotates about the travel axis of the quill relative to the quill and is moveable along the axis with the quill. A rack on the quill is parallel to the travel axis and engages a feed gear such than when the feed gear is rotated the rack and quill move along the travel axis.
Patent EP-1197735-B1 (EP)
Inventor: MIZUNO SEIICHIRO
IPC: H01L31/02
Filed: 2000-04-27
Granted: 2010-05-05
Abstract: La présente invention concerne une photodiode (PD) qui produit un courant de signal de sortie correspondant à la quantité de lumière reçue. Un montage intégrateur (10) stocke une charge correspondant au courant de signal et produit une tension de signal correspondant au montant de la charge stockée. Dans un circuit CDS (20), la tension de signal en provenance du montage intégrateur (10) est appliquée à des condensateurs (C22, C23) par des commutateurs (SW21 à SW23). Un amplificateur différentiel (30) détermine la différence entre les charges stockée dans les condensateurs (C22, C23) du circuit CDS (20), et produit une tension de signal correspondant à cette différence.
Patent EP-1173172-B1 (EP)
Inventor: MASON R PRESTON
IPC: A61K31/4422
Filed: 2000-04-18
Granted: 2006-01-04
Abstract: La combinaison d'amlodipine avec de l'atorvastatine ou un métabolite d'atorvastatine produit un effet antioxydant synergique sur la peroxydation lipidique dans les lipoprotéines de basse densité et les vésicules membranaires humaines enrichies avec des acides gras polyinsaturés. On a observé que cette combinaison médicamenteuse inhibait l'activité nuisible des radicaux hydroxy à des niveaux thérapeutiques, propriété impossible à reproduire par la combinaison d'amlodipine avec d'autres statines ou avec la vitamine E, antioxydant naturel. On attribue cette puissante activité aux structures chimiques de ces composés et à leurs interactions moléculaires avec des molécules phospholipidiques, comme l'ont montré les analyses par diffraction de rayons X. Cette polythérapie peut servir à traiter les troubles cardiovasculaires, et notamment la coronaropathie, grâce à l'augmentation de la résistance des lipoprotéines de basse densité et des membranes cellulaires vasculaires aux modifications oxydatives.
Patent EP-1180121-B1 (EP)
Inventor: BRIDON DOMINIQUE P
IPC: C07K14/16
Filed: 2000-05-17
Granted: 2003-10-22
Abstract: Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a blood protein. Conjugates are prepared from anti-angiogenic peptides, particularly kringle 5 peptides, by combining the peptide with a reactive functional group with a blood protein. The conjugates may be formed in vivo or ex vivo. The conjugates are administered to patients to provide an anti-angiogenic effect.
Patent EP-1196743-B1 (EP)
Inventor: BROWN GEORGE ALBERT
IPC: E21B47/10
Filed: 2000-07-06
Granted: 2003-09-17
Abstract: A fiber optic sensor system provides sufficient thermal information to determine the mass flow rates of produced fluids within a well bore, using an optical fiber placed within or adjacent to the well bore without interference with production or prejudicing the integrity of the well. Mass flow rates of fluid in a conduit ( 20 ) located in a heat sink differing in temperature from the fluid are determined by obtaining a distributed temperature profile ( 32 ) of fluid flowing along a length of conduit ( 15 ) by using optical data obtained from a length of optical fiber in thermal contact therewith, obtaining a profile of the heat sink temperature external to the conduit, and deriving mass flow rates of fluids in the conduit from the said profiles and from measured thermal transfer parameters.