Patent SG-11201903753Q-A (SG)
Title: Zinc-?-pga compositions and methods for treating cancer
Inventor: CHUNG JINHYUK FRED
IPC: A61K47/64
Filed: 2017-10-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) -., (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......'\"' WO 2018/084806 Al 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, A61K 33/30 (2006.01) A61P 35/00 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, A61K 47/64 (2017.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/SG2017/050545 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 31 October 2017 (31.10.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 10201609131Y 01 November 2016 (01.11.2016) SG MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant: XYLONIX IP HOLDINGS PTE. LTD. KM, ML, MR, NE, SN, TD, TG). [SG/SG]; 10 Anson Road, #28-05A, International Plaza, Singapore 079903 (SG). Declarations under Rule 4.17: (72) Inventor: CHUNG, Jinhyuk Fred; 31 Poole Road, Singa- — of inventorship (Rule 4.17(iv)) pore 437522 (SG). Published: (74) Agent: PIZZEYS PTE LTD; 152 Beach Road, #04-08 — with international search report (Art. 21(3)) — Gateway East, Singapore 189721 (SG). = (81) Designated States (unless otherwise indicated, for every = _ kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (54) Title: = ZINC-y-PGA COMPOSITIONS AND METHODS FOR TREATING CANCER (57) : The invention relates to pharmaceutical compositions FIGURE 2 comprising a zinc salt and a y-polyglutamic acid carrier, and, option- 2+ ally, an NF-kB inhibitor as a tumor-sensitizing agent, and methods for using such compositions to treat tumors in patients. Methods include NCI H460 lung cancer cell: administering a liquid dosage form or a solid dosage form of a thera- WT p53, no drug resistance traits lly effective amount of a Zn(ll) salt and a y-polyglutamic acid = = '\"\"''''' r= rN\"r\". ze o 7::t - ,,\",:= \"cr— :=1; carrier to a patient in need thereof. Methods of treating a broad spectrum of human tumors, including tumors with a drug-resistant phenotype, us- ing the disclosed compositions are Tumors that respond to the provided. = _ ..-. .,.g: ...... ,,,.:;:l .—., v „::: .... : u. !7! y _, pharmaceutical compositions disclosed herein include neuroendocrine = — 04 — ' = E M ES-SA Dx5 P-glycoprotein human sarcoma: (neuroblastoma), gastric, uterine, and lung tumors. expression, WT p53 w 'a 0 '' Ar= N \"'''' ,, N = \"\"\"' =:‘ 1 '''''' Ne 7::‘ ,- 1 g of , ,.,, Lin rolls E Li se .ells fatty _ Early sells Pa%psis 0- 0 L- C> GC T98G human neuroblastoma: Mul4drug Resistance Protein 1 (MRP1) expression, p53 defects 8/08 4 7— Llve apog LIve cells Earl Early 1 ApcgtI: ] r il. celk LEarl 14,1 , ' se is msls Il 0 Annexin V - FITC binding N C