Patent SG-11201408340S-A (SG)
Title: Angiopoietin-like 4 antibody and a method of its use in cancer treatment
Inventor: LESCAR JULIEN
IPC: A61P35/04
Filed: 2013-08-06
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 February 2014 (20.02.2014) WIPOIPCT (10) International Publication Number WO 2014/027959 A1 (51) International Patent Classification: C07K16/18 (2006.01) A61P 35/04 (2006.01) A61K39/395 (2006.01) (21) International Application Number: (72) (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/SG2013/000331 6 August 2013 (06.08.2013) English English (30) Priority Data: 61/682,920 14 August 2012 (14.08.2012) US (71) Applicant: NANYANG TECHNOLOGICAL UNIVER­ SITY [SG/SG]; 50 Nanyang Avenue, Singapore 639798 (SG). Inventors: LESCAR, Julien; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). WONG, Yee Hwa; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). CHUA, Wei Min Edmond; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). TAN, Nguan Soon Andrew; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). CHONG, Han Chung Kelvin; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). TAN, Ming Jie; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). HUANG, Roy- ston-Luke; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). [Continued on next page] (54) Title: ANGIOPOIETIN-LIKE 4 ANTIBODY AND A METHOD OF ITS USE IN CANCER TREATMENT goc akc gag ctc ocfc cag tct c 1 2 3 4 S 5 7 0 I E L T Q S l get tct ttg get gtg tct eta ggg <og agg gee occ 9 1® 11 12 13 14 15 l« 17 IS 19 2& ASLAVSLCQRAT (57) Abstract: An antibody that binds C terminal region of angiopoietin like protein its use and methods 4 of treating can­ cer with the same. otc ice tgc esg get age caa ogt gtt gat tot gat ggt got ogt tat ttg aac tgg tfcc 21 22 23 24 25 26 17 2S 2fl 3® 31 32 33 iM SS 56 3? tt 39 4& ISCXASQSVDfDCOSYLtlHF • Li - caa cag aaa c eg gga cag cca ccc ao a ctc ctc ctc tat oct gca tcc act eta gca tct 41 42 43 44 -15 46 4 7 43 49 SB 31 52 S3 54 55 56 S? 58 59 68 4QKPGQPPKILIYTASNLES < 12 §ga ate cca gcc agg tfct ogt ggc: agt ggg tct ggg oca gar, ttc occ etc aac otc est 62 63 (A S5 66 6? 68 69 TO ?1 12 73 74 75 76 77 78 79 fi» CSPARPSGSC. SCTOFTLMIK cCt gtg g<% &Q gag gat get gca acc tat tac tgt oag cos agt oat gag got ccg tg$ SI 82 S3 W SS 84 4? S3 89 S& 91 93 W 95 9® £7 98 99 1M PYEEEOfiATVyCQQSNEDPW 13 ocg tic ggt §ga ggc ate oag ttg gca atfl <aaa egg Ifll 182 103 184 185 106 US? 163 1B9 110 111 112 TF6GGTKLE2KS Heavy chain cag gfcg caa ctg cog gag tct gac cct ggg eta ttg aag ccc tea cag acc ctc agt ctg i 2 3 4 5 6 7 3 9 1» U 12 13 14 15 16 17 18 13 itt QV QlQfSGP&ZlKPSQTLSL <jct tgt tct ttc tct ggg ttt tco ctg age set tct ggt atg ggt gto ggc tgg ott tgt 21 22 23 24 25 26 27 2S 29 3& 31 32 33 34 35 .36 37 38 39 4ft TCSFSCFSLSTSGMGVGHIR Hi > cog cct tea ggg aag ggt ctg gag tgg ctg gca cac att tgg tgg gat got got cog tac 41 42 43 44 45 +6 47 48 49 5& 51 52 S3 S4 55 56 57 58 59 £0 QPS&KCLE ffLAH ItfHODDKy < H2 tat aac cca tcc ctg aag age cag ctc aco ate tee asg 61 62 63 64 6S £6 67 S2 63 ?& 72 72 73 VNPSLKSQiTISS $at acc tcc aga aac cag gto 74 75 76 77 74 ?3 I® £> T S ft H $ V ir. o\ i> rs o ttc ctc aag ate ate ogt gtg gac act gca gat act gcc act toe tac tgt get cga add B1 82 83 34 85 S6 &7 &Z S9 3d il «2 93 54 95 S6 37 9S 93 ICS FLKttSVftTAOTATYVCik'ftK gac tac gge agt ogt tac ©ac toe tgg ggc cca ggg occ acg gtc acc gtc tcc Ifll 102 m M 105 106 107 IdS 169 110 111 112 113 114 115 116 117 118 0*6 SSYfiyWGfiCTTVTyS H3 > O CJ o & WO 2014/027959 A11II llll IIII III III Hill III III III Hill 111 II lllll llll 111 mill llll 111 llll (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa­ pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))