baber/WOPTO huggingface dataset:
Patent NZ-500007-A (NZ)
Title: Anticoagulant fusion protein anchored to cell membrane to prevent organ rejection after a transplant
Inventor: RIESBECK KRISTIAN
IPC: H04W4/00
Filed: 1998-03-26
Abstract: A chimeric protein with an anchor region and anticoagulant activity is described.  Expression of these proteins renders cells, tissues and organs less vulnerable to rejection after transplantation (e.g. after xenotransplantation).  These anticoagulant proteins are prevented from being constitutively expressed at the cell surface. In particular, expression at the cell surface is regulated according to cell activation. The anchor region can be any entity capable to attaching the protein to the cell lipid bilayer.  These regions can be the transmembrane sequences from membrane proteins such as the HLA class I or CD4 proteins.  Alternatively, the anchor region might be a sequence conferring on the protein the ability to associate extracellularly with a membrane protein without the protein itself being inserted into the cell membrane. The anticoagulant can comprise the sequence of any anticoagulant polypeptide such as heparin, TAPs (tick anticoagulant peptides), antithrombin, hirudins, TFPIs (tissue factor pathway inhibitors) and snake venom factors. The protein further comprises a targeting sequence that prevents the protein from being constitutively expressed at the cell surface.  The targeting sequence is a polypeptide sequence that can target a nascent polypeptide to a secretory granule that does not fuse with the cell's plasma membrane until the cell is suitably stimulated.  For example, Weibel-Palade bodies do not fuse with the plasma membrane until the endothelial cell surface is stimulated by a secretagogue, such as thrombin or fibrin. Figure 1 shows maps of hirudin-CD4 chimeric proteins and constructs.  (A) HLA-hirudin-CD4 constructs with glycine linkers. (B) HLA-hirudin-CD4 construct with human P-selectin C-terminal, with the specific targeting sequence underlined.
Patent NZ-502988-A (NZ)
Title: 5-Acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene useful for treating influenza
Inventor: LIU HATONGA
IPC: C07C311/14
Filed: 1998-09-15
Abstract: A composition comprises an enterically protected 5-acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene of formula (I), which is useful for inhibiting the activity of neuraminidase or for treating or the prophylaxis of an influenza infection.
Patent NZ-505856-A (NZ)
Title: (1,4-benzoquinonyl)alkanoic acid ester derivatives and pharmaceuticals thereof; useful for the production of an anti-proliferative effect in a warm-blooded animal
Inventor: BOYLE FRANCIS THOMAS
IPC: C07D295/135
Filed: 1999-03-16
Abstract: An anti-tumour agent of the formula I, wherein: R1, R2 and R3 are independently selected from H, alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, pyrrolidin-1-ylalkyl, piperidinoalkyl, morpholinoalkyl, piperazin-1-yl-alkyl, 4-alkylpiperazin-1-ylalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, N-alkylcarbamoyl-alkyl, N,N-dialkylcarbamoylalkyl, amino, alkylamino, alkenylamino, alkynylamino, dialkylamino, dialkenylamino, dialkynylamino, pyrrolidin-1-yl, piperidino, morpholino, piperazin-1-yl, 4-alkylpiperazin-1-yl, hydroxyalkylamino, alkoxyalkylamino, aminoalkylamino, alkylaminoalkylamino, dialkylaminoalkylamino, pyrrolidin-1-yl-alkylamino, piperidinoalkylamino, morpholino-alkylamino, piperazin-1-yl-alkylamino, 4-alkylpiperazin-1-yl-alkylamino, alkanoylamino, alkanoylaminoalkylamino, carboxyalkylamino, alkoxycarbonylalkylamino, carbamoylalkylamino, N-alkylcarbamoylalkylamino, N,N-dialkylcarbamoylalkylamino, hydroxy, alkoxy, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, pyrrolidin-1-yl-alkoxy, piperidino-alkoxy, morpholino-alkoxy, piperazin-1-yl-alkoxy or 4-alkylpiperazin-1-yl-alkoxy; R4 is alkyl; R5 is alkyl; R6 is H or alkyl; R7 is H or alkyl; X is oxygen; m is 1 or 2 and each R8 is independently H, halogeno, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkyl, alkenyl, alkynyl, amino, alkylamino, dialkylamino, cyano, alkanoylamino, carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or N,N-dialkylcarbamoyl; Y1 is halogeno, alkanesulphonyloxy, benzenesulphonyloxy or phenylalkanesulphonyloxy; Y2 is halogeno, alkanesulphonyloxy, benzenesulphonyloxy or phenylalkanesulphonyloxy; Any heterocyclic group in R1, R2 or R3 is optionally substituted with 1, 2 or 3 alkyl substituents, and wherein any phenyl group in Y1 or Y2 when Y1 and Y2 is benzenesulphonyloxy or phenylalkanesulphonyloxy is optionally substituted with 1, 2 or 3 substituents selected from halogeno, nitro, cyano, trifluoromethyl, hydroxy, amino, alkyl, alkoxy, alkylamino and dialkylamino; With the proviso that at least one of R1, R2 and R3 is other than hydrogen. Also described is a pharmaceutical composition comprising the compound of formula I. The compound of formula I is useful for producing an anti-proliferative effect in a warm-blooded animal.
Patent NZ-508787-A (NZ)
Title: Method for controlling a coating process by performing spectrometric measurements on the coating
Inventor: FOLESTAD STAFFAN
IPC: G01N21/35
Filed: 1999-07-07
Abstract: This invention relates to a method for controlling the process of manufacturing a coating of a pharmaceutical product, comprising the steps of: performing a spectrometric measurement on said coating; generating a sample vector of measurement values from said spectrometric measurement; condensing said measurement values into at least one principal parameter; comparing said at least one principal parameter to a predetermined corresponding model parameter; determining deviations of said at least one principal parameter from said corresponding model parameter and extracting information directly related to the quality of said coating; and controlling the process on basis, at least partly, of said information.
Patent NZ-512251-A (NZ)
Title: Composition for optimizing muscle performance during exercise containing ciwuija
Inventor: PORTMAN ROBERT
IPC: A23L33/00
Filed: 1999-11-11
Abstract: A dry powder nutritional composition for optimizing muscle performance during exercise and for enhancing muscle cell repair and recovery following the cessation of exercise comprises (by weight): a) 68.00% to 88.00% of one or more sugars for providing energy during exercise with 50.00% to 70.0% being high glycemic sugars and 8.00% to 20.00% being low glycemic sugars; b) 17.00% to 22.00% of one or more proteins for stimulating the release of insulin to the muscle cells during exercise and for repairing muscle cells after exercise; c) 0.50% to 2.00% of glutamine for reducing muscle stress by stimulating the immune system and for stimulating muscle cell recovery after exercise; d) 1.00% to 3.00% of arginine for stimulating the release of insulin within the muscle cells in order to facilitate the transport of glucose into the muscle cells during exercise and for the synthesis of glucose into glycogen; e) 0.50% to 2.00% of vitamin C for use as an anti-oxidant for preventing free radical formation during exercise and for protecting muscle cell integrity during exercise; f) 0.50% to 2.00% of vitamin E for use as an anti-oxidant for preventing free radical formation during exercise and for protecting muscle cell integrity during exercise; g) 0.10% to 2.00% of a sodium ion (Na+) compounds for replenishing electrolytes lost during exercise and for facilitating intestinal reabsorption of fluids; h) 0.10% to 2.00%  of a potassium ion  (K+) for replenishing electrolytes lost during exercise and for facilitating intestinal reabsorption of fluids; i) 0.10% to 2.00% of a magnesium ion (Mg2+) for replenishing electrolytes lost during exercise and for facilitating energy dependent processes; j) 0.50% to 3.00% of ciwujia for enhancing the immune system, reducing muscle stress, and decreasing heart rate during exercise; and k) 2.00% to 5.00% of one or more of leucine, isoleucine or valine for providing energy during exercise and for repairing muscle cell damage after exercise. The nutritional composition described above can be in the form a liquid further containing 80-85% by weight of water or juice providing a liquid carrier for the dry powder.
Patent NZ-512521-A (NZ)
Title: Selection system and method for animals for milking and for managing their movement around grazing area
Inventor: COPEMAN PETER JAMES ALBERT
IPC: A01J5/017
Filed: 2001-06-21
Abstract: A selection system (10) for animals comprises: a milking area (20) arranged to enable milking of one or more lactating animals; an attractant station (40) located in a grazing area (50) in a position external to, and remote from the milking area (20), the attractant station includes an attractant configured to attract an animal from the grazing area; an entry race (70) connecting the drinking station and the milking area; and a control mechanism (60) configured to permit entry of a lactating animal meeting a predefined criterion into the entry race from the attraction station.
Patent NZ-517221-A (NZ)
Title: Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
Inventor: MOE SCOTT T
IPC: A61K31/4725
Filed: 2000-08-18
Abstract: Compound of formula (II) wherein X, Y, and Z are N and Ar1 and Ar2 optionally substituted phenyl 2-pyridyl. The compounds act as antagonists at metabotropic glutamate receptors, and are useful for treating neurological diseases and disorders.
Patent NZ-517401-A (NZ)
Title: A leak proof, resealable container and cap assembly, cap attached to the container by a hinge
Inventor: BUCHOLTZ MICHAEL
IPC: B65D43/16
Filed: 2000-08-31
Abstract: A leak proof, resealable container and cap assembly (10) is disclosed, which consists of a container (20) having a rim (22) at its upper portion and a cap (30) having a hinge (40) attached to the container and a circular base (31) with an outer periphery, a cylindrical tubular skirt (33) having an inner wall with at least one recess (32) having at least two angular plane surfaces has opposing ends, a thumb tab (36) for facilitating the opening and closing of the container (20), the thumb tab (36) and the hinge (40) being positioned on opposing ends of the cap and extending perpendicularly and outwardly from the skirt of the cap (30); and in a closed position, the skirt (33) of the cap overlies the container (30) and the rim (22) of the container (30) is situated within the recess (32) of the inner wall of the skirt (33) of the cap (30) that results in a leak proof container, wherein the container is capable of being sealed and resealed by applying in a singular motion, a frontal, downward pressure upon the thumb tab to obtain a leak proof seal.
Patent NZ-521616-A (NZ)
Title: Method of associating tracers of image-based items with an entry and associating with item with logical group of tracer if entry is not found
Inventor: RUSSELL GRAHAM
IPC: G06F19/00
Filed: 2001-09-04
Abstract: The method is directed towards operating an image-based item processing system. In the first step, the method determines whether physical tracer items are associated with an entry. If the determination yields a negative, the entry is associated with a logical group of tracer items.
Patent NZ-522212-A (NZ)
Title: Downhole electrical well heating system and method
Inventor: DE ROUFFIGNAC ERIC
IPC: E21B43/24
Filed: 2001-04-24
Abstract: A system for heating an underground hydrocarbon containing formation (516) comprises an electrical conductor disposed within a heater well (514) traversing the formation to provide radiant heat to at least a portion of the formation to initiate pyrolysis of hydrocarbons, wherein the electrical conductor comprises one or more elongate electrically conductive heater members (600) which are each suspended in a fluid filled section of a heater well by a support member (604). The heater members may be bare metal strips or rods and may be arranged in an uncased section of the heater well in which a pressurized fluid, such as air, is circulated to remove hydrocarbon deposits from the heater members.
Patent NZ-524973-A (NZ)
Title: Process for the production of chiral compounds
Inventor: GERLACH MATTHIAS
IPC: C07C323/60
Filed: 2001-09-14
Abstract: Disclosed are compounds and processes for the production of compounds of formula 31, wherein: R1, R2 and R3 are independently selected from alkyl, and R4 is alkyl, cycloalkyl, aryl or heteroaryl.
Patent NZ-526265-A (NZ)
Title: Dairy product and process
Inventor: HONORE CRAIG GRAHAM
IPC: A23C19/08
Filed: 2003-06-04
Abstract: A method for producing a particulate cheese curd suitable for the preparation of a processed cheese comprising the steps of: forming a coagulum of cheese curd from milk, salting said coagulum and draining whey therefrom to form a curd, forming said curd into particles with a particle size suitable for drying, and drying said formed curd particles to a moisture level between 5% and 30% (W/W). A particulate cheese curd having a particle size no greater than 20 mm mesh and having a moisture content between 5% and 30% (W/W) is also disclosed.
Patent NZ-526533-A (NZ)
Title: Culturing tissue using magnetically generated mechanical stresses
Inventor: EL-HAJ ALICIA JENNIFER HAFEEZA
IPC: C12N5/07
Filed: 2001-12-19
Abstract: A method of culturing tissue comprises growing tissue forming cells whilst subjecting the tissue forming cells to mechanical stresses which are generated magnetically.
Patent NZ-530495-A (NZ)
Title: Thienopyrimidinediones and their use in the modulation of autoimmune disease
Inventor: REYNOLDS HEULWEN RACHEL
IPC: A61P9/10
Filed: 2002-07-24
Abstract: Thienopyrimidinedione compounds of formula (1)and their use in the modulation of autoimmune disease are disclosed; wherein: R1 and R2 each independently represent a C1-6 alkyl, C3-6 alkenyl, C3-6 cycloalkyl C1-3 alkyl or C3-6 cycloalkyl, each of which may be optionally substituted by 1 to 3 halogen atoms; R3 is isoxyzolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is CO- or C(R4)(R5)- (wherein R4 is a hydrogen atom or C1-4 alkyl and R5 is a hydrogen atom or hydroxy group); Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. Methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease are also described.
Patent NZ-531651-A (NZ)
Title: Phenethanolamine derivatives for treatment of respiratory diseases
Inventor: BOX PHILIP CHARLES
IPC: C07C317/14
Filed: 2002-09-11
Abstract: Compounds of formula (I), a process for their manufacture, pharmaceutical formulations comprising such compounds and their use in the manufacture of a medicament for the prophylaxis or treatment of a clinical condition for which a selective Beta-adrenoreceptor agonist is indicated.
Patent NZ-533653-A (NZ)
Title: Polymer particles with select pendant groups and aqueous compositions prepared therefrom
Inventor: BROWN WARD THOMAS
IPC: C08F265/06
Filed: 2003-08-29
Abstract: Polymer particles having select functional or absorbing groups are disclosed. The polymer particles are useful for preparing organic-inorganic composite particles that are suitable for providing dried coatings with improved hiding. Aqueous compositions containing these composite particles are also provided. The select absorbing groups include phosphorus acid groups, phosphorus acid full-ester groups, polyacid sidechain groups, and salts thereof. The select functional groups are capable of forming covalently bonded composite particles. The composite particles formed from the multistage polymer particles having the select functional or absorbing groups are useful for preparing dried coatings with a combination of improved hiding, increased gloss, and good film properties. (62) Divided out of 527905
Patent NZ-534497-A (NZ)
Title: Bi-directional thruster pig apparatus and method of utilizing same
Inventor: CRAWFORD JAMES R
IPC: E21B37/00
Filed: 2002-11-05
Abstract: A retrievable pig apparatus (10) having a substantially cylindrical body portion (32), the body portion (32) having a central flow bore (34) therethrough, and secured to coiled tubing (22), including a central fluid flow bore (34) in fluid communication with the interior bore of the coiled tubing (35); a plurality of flow bores (40) spaced equally apart within the body, with the flow bores (40) allowing fluid flow to be injected at a certain predetermined pressure through the flow bores (40), so as to be emitted on the front end of the pig for defining a high pressure spray of fluid or the like material to break up blockages of debris (70) in the pipeline, such as paraffin or the like; the debris (70) retrieved through the central bore (34) back into the coiled tubing (35) to be stored in a tank (157) or the like on the surface. There is further included a plurality of flexible cups (24), spaced apart along the outer wall of the pig body (25), each cup (24) secured to an interior metallic ring (26) around the body (25) of the pig, with the flexible cups (24) making contact with the wall (13) of the pipeline so as to provide a continuous fluid seal between the wall (13) of the pipeline and the ends of the plurality of flexible cups (24). Intermediate each cup (24) there is provided a compressible safety ring (28), which will compress under excess pipeline pressure, thus allowing the fluid to flow past the plurality of flexible cups (24), reducing the pressure in the pipeline. Further there is provided within the plurality of six flow bores (40) around the interior flow bore (34), for adjusting the force that is allowed to flow through the plurality of bores (40) in either direction by providing a first and second thruster springs (42, 44) of a pre-determined compressible force for allowing the springs (42, 44) to be compressed and effecting fluid flow therethrough in the direction in which the flow is to travel in the bores (40).
Patent NZ-545454-A (NZ)
Title: 1-(2-amino-benzoyl)-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
Inventor: ALBERATI-GIANI DANIELA
IPC: A61K31/496
Filed: 2004-08-30
Abstract: Disclosed is a compound of formula (I) wherein the substituents are described in the specifications for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
Patent NZ-548454-A (NZ)
Title: Pharmaceutical compositions comprising midazolam in a high concentration
Inventor: MERKUS FRANCISCUS WILHELMUS HENRICUS MARIA
IPC: A61K9/00
Filed: 2005-01-13
Abstract: Disclosed is a pharmaceutical composition for intranasal administration, which composition is an aqueous solution comprising midazolam in a concentration of at least 35 mg/mL and a solubiliser selected from propylene glycol, glycerol, polyethylene glycol, povidone, ethanol and combination thereof, wherein the pH of the composition is at least 2.5 and less than 4.
Patent NZ-554386-A (NZ)
Title: Gastric inhibtory polypeptide (GIP) antigen arrays with VLPs and uses thereof
Inventor: BACHMANN MARTIN
IPC: A61P3/04
Filed: 2005-10-25
Abstract: A composition comprising: (a) a virus-like particle (VLP) with at least one first attachment site; wherein said VLP is a VLP of an RNA-phage; and (b) at least one antigen with at least one second attachment site, wherein said at least one antigen is a Gastric Inhibitory Peptide (GlP) protein or a GIP fragment, wherein said antigen is selected for its ability to induce an immune response against GIP when linked to said VLP; and wherein (a) and (b) are linked through said at least one first and said at least one second attachment site.
Patent NZ-555098-A (NZ)
Title: Articulating crack curing lamp and method
Inventor: BEVERIDGE KEITH A
IPC: B29C35/08
Filed: 2005-11-02
Abstract: Disclosed is a curing lamp apparatus which is mounted to a work surface (11) with a suction cup (24). A base (12) is mounted to the suction cup and defines a hinge point (28) for a first bar (38). At a distal end of the first bar, a second bar (56) is hingedly mounted to the first bar. A first lamp element (16) is hingedly mounted to one end of the second bar. A second lamp element (18) is hingedly mounted to a second end of the second bar. The first and second lamp elements are positionable in a variety of positions to follow the path of a crack (13) in a surface to be repaired. The lamp elements are also foldable into a storage position.
Patent NZ-563344-A (NZ)
Title: Management and analysis of cargo shipments
Inventor: TRELLEVIK KNUT ARNE
IPC: G06Q50/00
Filed: 2006-06-05
Abstract: A method for collecting and managing information related to the shipping and condition of a cargo during a cargo voyage from a source to a destination is disclosed. An electronic cargo voyage folder (ECVF) associated with the cargo is created, including a cargo id, cargo contents and shipping methods for the cargo voyage. At the source a first assessment of an initial cargo condition is requested and the first assessment of the cargo condition, a first place of assessment and a first time of assessment is recorded in the ECVF. The events occurring during the cargo voyage are also recorded in the ECVF. At the destination, a second assessment of the cargo condition is requested and a second assessment of the cargo condition, a second place of assessment and a second time of assessment is recorded in the ECVF.
Patent NZ-564362-A (NZ)
Title: Process for improving shelf life of refrigerated foods
Inventor: WARNE DARIAN
Filed: 2006-06-13
Abstract: A process for producing a food product having an extended refrigerated shelf life of at least six months comprising: sealing food in a container prior to heating to inactivate undesirable microorganisms; heating the food in the sealed container at a temperature to achieve a minimum Fp value equivalent to about 20 minutes at 90 degrees C to inactivate undesirable microorganisms likely to be present in the food; and rapidly cooling the heated food at a rate of at least about 2 degrees C per minute to substantially prevent germination of undesirable microbial spores likely to be present in the food.
Patent NZ-566804-A (NZ)
Title: New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of alzheimer's disease
Inventor: ANDERSSON LARS
IPC: A61K31/506
Filed: 2006-10-02
Abstract: Disclosed is the use of the compound of formula I or a salt thereof, where the substituents are as defined in the specification, for prevention or treatment of dementia, Alzheimer's Disease, Parkinson's Disease, Frontotemporal dementia Parkinson's Type, Parkinson dementia complex of Guam, HIV dementia, diseases with associated neurofibrillar tangle pathologies and dementia pugilistica. Also disclosed are specific compounds of formula I where R6 is tetrahydropyran and wherein the other substituents are as defined in the specification. Also disclosed is a process for synthesising a compound of formula I.
Patent NZ-566817-A (NZ)
Title: Modified chaperonin 10, wherein the N-terminus comprises a single additional glycine residue compared to a corresponding mammalian wild-type
Inventor: NAYLOR DEAN JASON
IPC: C07K16/44
Filed: 2006-08-31
Abstract: Disclosed is an isolated Chaperonin 10 (Cpn10) polypeptide, wherein the N-terminus of said polypeptide comprises a single additional glycine residue compared to a corresponding mammalian wild-type Cpn10 polypeptide. Also disclosed is the use of the Cpn10 polypeptide for the manufacture of a medicament for treating a disease, disorder or condition selected from acute or chronic inflammatory diseases, asthma, allergy, multiple sclerosis, GVHD, an autoimmune disease or an infectious disease.