Patent EA-003321-B1 (EA)
Title: Substituted aminocycloalkylpyrrolidine derivatives
Inventor: TAKAHASHI HISASHI
IPC: A23K20/195
Filed: 1996-11-22
Abstract: 1. A compound represented by formula (I): wherein substituent R<1> represents a hydrogen atom; substituent R<2> represents a hydrogen atom, substituent R<2> represents a hydrogen atom, substituents R<4> and R<5>, each independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms which can be substituted by hydroxy group. n has the entire values from 1 to 3; and Q represents partial structure of formula (II): wherein R<8> represents an alkyl group having 1 to 6 carbon atoms, a halogen alkyl group having 1 to 6 carbon atoms and cyclic alkyl structure having 3 to 6 carbon atoms, which can have substituents(and), substituent R<9> represents hydrogen atom; substituent X<1> represents halogen atom or hydrogen. A<1> represents a nitrogen atom, or a partial structure represented by formula (III): wherein X<2> represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxyl group having 1 to 6 carbon atoms, X<2> and R<8> may be combined to form a cyclic structure including a part of the mother nucleus, and the ring may contain an oxygen atom as a ring constituting atom and may further have an alkyl group having 1 to 6 carbon atoms; and substituent Y<1> represents a hydrogen atom, or a partial structure represented by formula (IV): wherein substituent R<11> represents an alkyl group having 1 to 6 carbon atoms, a halogenoalkyl group having 1 to 6 carbon atoms, or a cyclic alkyl group having 3 to 6 carbon atoms which may have a substituent(s), an aryl group which may have a substituent(s), a heteroaryl group which may have a substituent(s); substituent R<12> represents a hydrogen atom, an amino group, substituent X<3> represents a hydrogen atom, a halogen atom; A<2> represents a nitrogen atom or a partial structure represented by formula (V): wherein X<4> represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxyl group having 1 to 6 carbon atoms, and substituent Y<2> represents a hydrogen atom and its salts and hydrates thereof. 2. The compound, its salts and hydrates thereof according to claim 1, wherein Q in the formula (I) has a structure represented by the formula (III). 3. The compound, its salts and hydrates thereof according to claim 2, wherein R<8> is a halogenocyclopropyl group. 4. The compound, its salts and hydrates thereof according to claim 1, wherein the halogenocyclopropyl group in the formula (I) is a 1,2-cis-2-halogenocyclopropyl group. 5. The compound, its salts and hydrates thereof according to claim 2, 3 or 4, wherein the halogenocyclopropyl group in the formula (I) is a stereochemically pure substituent. 6. The compound, its salts and hydrates thereof according to claim 5, wherein the halogenocyclopropyl group in the formula (I) is a (1R, 2S)-2-halogenocyclopropyl group. 7. The compound, its salts and hydrates thereof according to claim 6, wherein the halogen atom of the halogenocyclopropyl group in the formula (I) is a fluorine atom. 8. The compound, its salts and hydrates thereof according to claim 7, wherein the compound of the formula (I) is a stereochemically pure compound. 9. A compound, its salt or a hydrate thereof disclosed in claim 1 with structural formula wherein Q is selected from partial structure, selected from 10. A compound, its salt or a hydrate thereof disclosed in claim 1 with structural formula. wherein Q represents partial structure 11. A pharmaceutical preparation, which comprises the compound, its salt or a hydrate thereof disclosed in claim 1 as an active ingredient. 12. An antibacterial drug which comprises the compound, its salt or a hydrate thereof disclosed in claim 1 as an active ingredient.