Patent SG-11201807188V-A (SG)
Title: Modified cells for immunotherapy
Inventor: DOTTI GIANPIETRO
IPC: C12N5/10
Filed: 2017-02-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111 HO 11111011101011101111101111111001111101111 MI International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/147383 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) C12N 5/10 (2006.01) kind A61K 35/17 (2015.01) AO, BZ, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/019301 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, 24 February 2017 (24.02.2017) MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, ZA, ZM, ZW. TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: 16020057.2 25 February 2016 (25.02.2016) EP (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: CELL MEDICA SWITZERLAND AG GM, [CH/CH]; Wagistrasse 27, 8952 Schlieren (CH). THE TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, UNIVERSITY OF NORTH CAROLINA AT CHAPEL TJ, HILL [US/US]; 100 Europa Drive, Suite 430, Chapel Hill, DK, NC 27517 (US). LV, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — (72) Inventors: DOTTI, Gianpietro; 111 Quaiview Dr., SM, Chapel Hill, NC 27516 (US). LANDONI, Elisa; 469 GW, KM, ML, MR, NE, SN, TD, TG). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Melanie Ct., Chapel Hill, NC 27514 (US). SHAMSHIEV, Declarations under Rule 4.17: Abdij apar; Buchzelgstrasse 64, 8053 Zurich (CH). — of inventorship (Rule 4.17(iv)) KRETZSCHMAR, Titus; Sonnhaldenstrasse 63b, 6331 Hunenberg (CH). DROSTE, Miriam; Grunaustrasse 14, Published: = 8953 Diietikon (CH). PHILIPS, Douglas; c/o Cell Medica with Switzerland AG, Wagistrasse 27, 8952 Schlieren (CH). international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) — (74) Agents: ELMORE, Carolyn, S. et al.; Elmore Patent Law = Group, P.C., 484 Groton Rd., Westford, MA 01886 (US). = = = = = = = = = Il M GC M IN 7r 11 IN 11 © (54) Title: MODIFIED CELLS FOR IMMUNOTHERAPY ei , (57) : The present invention relates to engineered immune cells expressing antigen receptors, such as a T cell receptor (TCR) or a chimeric antigen receptor (CAR), as well as antibody targeting PD-Ll. Also provided are related nucleic acids, vectors, compositions and method for enhancing the immune response towards cancers and pathogens.