Patent SG-11201807038U-A (SG)
Title: Rodents having a humanized tmprss gene
Inventor: Purcell Ngambo Lisa
IPC: C12N9/64
Filed: 2017-02-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIMI41101110101011111 HO 11111011101 Ell 01011111101100111110 1111 III International Bureau 0.. .... .. (10) International Publication Number ..... ...,/ (43) International Publication Date WO 2017/151453 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, AO1K 67/027 (2006.01) Cl 2N 9/64 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/019574 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 27 February 2017 (27.02.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/301,023 29 February 2016 (29.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: REGENERON PHARMACEUTICALS, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, New York 10591-6707 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) L Inventors: PURCELL NGAMBO, Lisa; c/o Regeneron V, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Pharmaceuticals, Inc., 777 Old Saw Mill River Road, GW, KM, ML, MR, NE, SN, TD, TG). Tarrytown, New York 10591-6707 (US). MUJICA, Alex- ander 0.; c/o Regeneron Pharmaceuticals, Inc., 777 Old Declarations under Rule 4.17: Saw Mill River Road, Tarrytown, New York 10591-6707 — as to applicant's entitlement to apply for and be a granted (US). TANG, Yajun; c/o Regeneron Pharmaceuticals, patent (Rule 4.17(ii)) Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Agent: GROLZ, Edward W.; Scully, Scott, Murphy & (74) Presser, 400 Garden City Plaza, Suite 300, Garden City, Published: New York 11530 (US). — with international search report (Art. 21(3)) Designated States (unless otherwise indicated, for every _ with sequence listing part of description (Rule 5.2(a)) kind of national protection available): AE, AG, AL, AM, (81) Il M kir) 71- 1-1 kir) 1-1 IN 1-1 © (54) ei Title: RODENTS HAVING A HUMANIZED TMPRSS GENE 0 (57) : Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss 1 1 d gene.