baber/WOPTO huggingface dataset:
Patent CA-2911292-C (CA)
Inventor: GALETTO ROMAN
IPC: C12N15/63
Filed: 2014-05-12
Granted: 2023-01-03
Abstract: The present invention relates to chimeric antigen receptors (CAR). CARs are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties. In particular, the present invention relates to a Chimeric Antigen Receptor in which extracellular ligand binding is a scFV derived from a CD19 monoclonal antibody, preferably 4G7. The present invention also relates to polynucleotides, vectors encoding said CAR and isolated cells expressing said CAR at their surface. The present invention also relates to methods for engineering immune cells expressing 4G7-CAR at their surface which confers a prolonged "activated" state on the transduced cell. The present invention is particularly useful for the treatment of B-cells lymphomas and leukemia.
Patent CA-2915914-C (CA)
Inventor: ELDUAYEN MADARIAGA JUAN ANDRES
IPC: F16L55/132
Filed: 2014-05-26
Granted: 2018-02-27
Abstract: Sealing plug (1) comprising an elastic body (2) and a stem (3) coaxially assembled to one another. The elastic body (2) comprises a main body (2a) which is suitable for being expanded radially when pulling on the free end (3a) of the stem (3) which emergences out of said elastic body (2). Said elastic body (2) also comprises a head (2b) attached to the main body (2a), said head (2b) comprising a compressive strength less than that comprised in the main body (2a).
Patent CA-2916564-C (CA)
Title: Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
Inventor: LI ZHE
IPC: A61K31/4439
Filed: 2015-02-05
Granted: 2023-02-28
Abstract: Disclosed are crystalline free base ansolvate and solvate forms of 2-hydroxy-6-((2-1-isopropy1-1H-pyrazol-5-yl)pyridine-3-yl)methoxy)benzaldehyde (or Compound 1), such as the free base Form I, Form 11 and Material N. These forms are used to prepare the solid crystalline free base of Compound 1 which may be used to increase oxygen affinity of hemoglobin in a subject, treating a disorder mediated by hemoglobin, or treating sickle cell disease.
Patent CA-2918392-C (CA)
Title: Multiple parts reed valve and method of manufacturing
Inventor: ROSA JOSE UBALDINO
IPC: F04B39/10
Filed: 2014-07-24
Granted: 2021-11-09
Abstract: An improved membrane valve and method for manufacturing such membrane valve. The improved membrane valve can be used for transferring fluids or gases in hermetic or semi-hermetic compressors, including a method and system for manufacturing a membrane valve and a membrane valve with applications for use in several motors, particularly in hermetic or semi-hermetic compressors which use, as a refrigeration fluid, an appropriate type of gas thus promoting the refrigeration physical affect. A body and a membrane of the membrane valve are produced from substantially thin metallic plates separately in accordance to an available process and can be subjected to rounding in order to eliminate live comers, and then juxtaposed thus composing the valve, with the above mentioned membrane on one side, fitted to the body which is fixed through a connection process and, on the other side, left free to oscillate
Patent CA-2926085-C (CA)
Inventor: ZHANG MENG
IPC: D21H17/00
Filed: 2014-10-13
Granted: 2023-02-14
Abstract: The invention provides a dialdehyde modified acrylamide type polymer for paper making, which is obtained by reacting a dialdehyde with an acrylamide type base polymer, wherein the acrylamide type base polymer is formed by copolymerization of an acrylamide type monomer, a cationic monomer and/or an anionic monomer and a cross linking agent. The invention further provides a method for preparing said dialdehyde modified acrylamide type polymer. The dialdehyde modified acrylamide type polymer according to the invention has improved stability while maintains excellent enhanced performance.
Patent CA-2926456-C (CA)
Title: Interrupteur unipolaire bidirectionnel ou bipolaire bidirectionnel avec combinaison de relais unipolaires bidirectionnels pour une utilisation dans la domotique
Inventor: ELBERBAUM DAVID
IPC: H01H50/16
Filed: 2014-10-01
Granted: 2017-08-22
Abstract: L'invention porte sur un procédé et un appareil permettant d'intégrer un interrupteur unique parmi une pluralité d'interrupteurs hybrides unipolaires bidirectionnels ou bipolaires bidirectionnels avec l'un des relais unipolaires bidirectionnels et bipolaires bidirectionnels, via des contacteurs structurés pour connecter les pôles du relais et l'interrupteur directement ou par le biais de structures conductrices, notamment un ensemble de carte de circuits imprimés, afin de faire fonctionner des appareils électriques grâce à la clé manuelle de l'interrupteur et à distance en alimentant la bobine de relais dotée ou non d'une armature de verrouillage, avec un programme informatique fournissant la clé manuelle et les clés manuelles de chaque interrupteur unipolaire bidirectionnel ou bipolaire bidirectionnel connecté par une ligne mobile au relais d'interrupteurs intégré, dans le but de mettre en marche et d'arrêter un groupe de charges et toutes les charges du réseau domotique via un câble optique, une télécommande RF ou IR en ligne de visée et un bus.
Patent CA-2929034-C (CA)
Inventor: NOWAK ANDREW P
IPC: C08K7/16
Filed: 2016-05-03
Granted: 2021-06-01
Abstract: A composition comprises a copolymer made from a thiol terminated hydrocarbon monomer and at least one additional monomer chosen from the compounds of i) a terminally unsaturated hydrocarbon monomer, ii) an isocyanate functionalized hydrocarbon monomer and iii) a silane monomer substituted with two or more C2 to C8 terminally unsaturated alkenyl groups or C2 to C8 terminally unsaturated alkynyl groups. The composition also includes a particulate filler dispersed in the copolymer and a solvent. lf the terminally unsaturated hydrocarbon monomer is polybutadiene, the polybutadiene contains from about 0 mol % to about 30 mol % of polymer units in a cis-1,4-butadiene form. Composites made from the composition and methods for making composite panels are also disclosed.
Patent CA-2939626-C (CA)
Title: Anticorps anti-composant c5 de du systeme de complement
Inventor: BACIU PETER C
IPC: C07K16/18
Filed: 2015-02-19
Granted: 2023-01-17
Abstract: La présente invention concerne des anticorps et des polynucléotides codant pour ceux-ci, pouvant être utilisés pour l'inhibition, la régulation ou la réduction de l'activité de la voie de signalisation du système de complément. L'invention concerne également des compositions et des procédés pour le diagnostic et le traitement de maladies médiées par ou impliquant un C5 du système de complément. D'une manière spécifique, l'invention se rapporte à des anticorps anti-C5.
Patent CA-2940823-C (CA)
Inventor: FUSSEY SHELLEY P M
IPC: G01N33/50
Filed: 2015-02-27
Granted: 2017-03-28
Abstract: Disclosed are surprising new methods and compositions for isolating extracellular microvesicles such as exosomes, particularly disease-related and phosphatidylserine (PS)-positive extracellular microvesicles as exemplified by tumor- and viral-derived exosomes. The methods of the invention are rapid, efficient, cost-effective and, importantly, are suitable for use with large volumes of biological fluids and produce antigenically intact extracellular microvesicles and exosomes. The methods and compositions are based on the surprising use of acetate buffers to isolate large quantities of extracellular microvesicles, particularly tumor-derived exosomes, from solution, without damaging their morphological or functional properties or antigenicity.
Patent CA-2941258-C (CA)
Title: Methods and systems for token-based application management
Inventor: ABBATE ALAIN D
IPC: G06F9/46
Filed: 2015-02-27
Granted: 2019-02-26
Abstract: Disclosed herein are methods and systems for token-based application management. In an embodiment, requests are received from applications for tokens that can be active or inactive. A token-interaction-directive pool is maintained in data storage, each directive having a triggering token, a target token, and one or both of triggering-token actions and target-token actions. Responsive to receiving a token request from an application, any directives having their triggering token equal the requested token and having their target token active are identified. A response plan that includes the actions in the identified directives is generated. Any triggering-token actions in the response plan are communicated to the requesting application, and any target-token actions in the response plan are communicated to each application that is authorized to access the corresponding target token.
Patent CA-2941740-C (CA)
Title: Membrane casing and membrane component
Inventor: WATANABE KEISHI
IPC: B01D63/00
Filed: 2015-03-10
Granted: 2022-01-04
Abstract: A non-cylindrical membrane casing watertightly houses a non-cylindical membrane element for filtering raw water. The membrane casing comprises a non-cylindrical casing main body, a lid body fitting an opening end of the casing main body and movable in an axial direction of the casing main body, a pressing mechanism pressing and holding the membrane element. The pressing mechanism comprises a supporting unit supported by the casing main body, a maintaining unit adjustably maintaining relative positions of the supporting unit and the lid body along the axial direction. The lid body is fitted to an opening end of the casing main body, a seal is disposed on an outer peripheral edge surface of the lid body to ensure watertightness with an inner peripheral face of the casing main body and the inner peripheral face of the casing main body is smooth at least in a moving range of the seal.
Patent CA-2942310-C (CA)
Inventor: LUMMIS WESLEY
IPC: A61F9/008
Filed: 2008-11-26
Granted: 2017-07-04
Abstract: An ophthalmic patient interface system includes an interface device and an ocular device. The interface device includes a frame having a first end and a second end, a lens disposed at the first end, and a skirt affixed to the first end. The second end is adapted to couple with a surgical laser system, and the skirt is adapted to seal against an anterior surface of an eye. The ocular device includes magnifying optics and is adapted to be removably seated within the second end. The magnifying optics image a region on a corneal side of the lens when the ocular device is seated within the second end.
Patent CA-2944261-C (CA)
Title: Additive concentrates for the formulation of lubricating oil compositions
Inventor: CLARKE DEAN B
IPC: C10M133/16
Filed: 2016-10-05
Granted: 2022-03-15
Abstract: A lubricant additive concentrate containing (i) dispersant that is the polybutenyl succinimide reaction product of a polyamine and polybutenyl succinic anhydride (PIBSA) derived from polybutene having a number average molecular weight (Mn) of from about 1300 to about 2500 daltons and a terminal vinylidene content of at least about 50% and maleic anhydride via an ene maleation process; (ii) overbased magnesium colloidal detergent having a total base number (TBN) of from about 300 to about 900 mg KOH/g; and (iii) organic friction modifier selected from hydroxyalkyl alkyl amines of C14 tO C24 hydrocarbons, at least one hydroxyalkyl alkyl ether amines of C13 to C24 hydrocarbons, at least one alkyl ester amine derived from triethanol amine having a C13 to C24 hydrocarbyl substituent, at least one non-basic, fatty acid amide, or a mixture thereof; wherein the combined mass% of dispersant (i) and overbased magnesium colloidal detergent (ii) in said concentrate is from about 15 to about 50 mass%: the mass ratio of (i):(ii) is from about 1:1 to about 6:1; and the concentrate contains from about 2 to about 10 mass% of organic friction modifier (iii); the remainder of the concentrate being composed of base oil and additives other than dispersant (i), overbased magnesium colloidal detergent (ii) and organic friction modifier (iii).
Patent CA-2947244-C (CA)
Inventor: PATEL SANJIV
IPC: G10K9/13
Filed: 2014-05-01
Granted: 2021-04-13
Abstract: An apparatus related to a contactless sound device, such as a horn, which may be configured to output different and/or multiple pitches using a replaceable, or interchangeable, electronic integrated circuit ("IC") module is disclosed. The electronic IC module may include one or more sequencers electrically connected via one or more relays to at least one signal generator which is electrically connected to an output driver. Each signal generator is configured to generate at least one frequency signal, and optionally multiple frequency signals. The electronic IC module may be physically attached to an IC connection interface located on the exterior of the contactless horn body. The IC connection interface electrically connects the electronic IC module to an electromagnet that drives the diaphragm of the contactless horn to create the selected preconfigured frequency sound.
Patent CA-2949376-C (CA)
Title: Detection de cellules independante de la croissance.
Inventor: REY DIEGO ARIEL
IPC: C12N7/00
Filed: 2015-06-12
Granted: 2021-06-29
Abstract: La présente invention porte sur divers procédés, systèmes et compositions pour la détection indépendante de la croissance de cellules telles que des micro-organismes, notamment des bactéries. Alors que les méthodologies de détection cellulaire existantes tirent avantage de la croissance de cellules, les procédés, systèmes et compositions selon la présente invention présentent des modes de réalisation qui sont indépendants de la croissance de cellules tout en permettant encore la détection à base de cellules.
Patent CA-2950374-C (CA)
Title: Compounds for treating brain cancer
Inventor: MEHRLING THOMAS JORG
IPC: A61K31/4184
Filed: 2015-03-26
Granted: 2023-10-03
Abstract: There is provided a compound of formula I or a pharmacologically acceptable salt thereof: for use in the treatment of a brain cancer selected from a MGMT positive astrocytic brain tumour, a metastatic brain cancer and primary CNS lymphoma and a method of treating said brain cancers in a patient in need thereof comprising administering to the patient said compound of formula I or a pharmacologically acceptable salt thereof.
Patent CA-2950911-C (CA)
Inventor: PACHE LARS
IPC: A61K31/554
Filed: 2015-06-04
Granted: 2023-10-10
Abstract: Provided herein are uses of at least one inhibitor of apoptosis proteins (IAP) antagonist for treatment of human immunodeficiency virus (HIV); wherein the IAP antagonist is a small molecule that has the following structure of Fonnula B-I, or pharmaceutically acceptable salt, N-oxide, racemate or stereoisomer thereof: Also provided are uses of the IAP antagonist for reducing dormant, replication competent human immunodeficiency virus (HIV), making dormant, replication competent human immunodeficiency virus (HIV) susceptible to immune system clearance, making dormant, replication competent human immunodeficiency virus (HIV) susceptible to the effects of antiretroviral therapy, eliminating replication competent human immunodeficiency virus (HIV), inducing long term control of human immunodeficiency virus (HIV) replication and growth in the absence of antiretroviral therapy, activating human immunodeficiency virus (HIV) transcription in latently infected cells, or reducing human immunodeficiency virus (HIV) reservoirs of latently infected cells in an individual in need thereof.
Patent CA-2956850-C (CA)
Title: A method of manual surface cleaning using cleaning textiles and of washing said cleaning textiles
Inventor: LEUCHTEN ELKE
IPC: A47L13/17
Filed: 2014-08-01
Granted: 2021-07-06
Abstract: The present invention refers to a method of manual surface cleaning comprising the steps of: a) wet wiping a surface with cleaning textiles wetted with a use solution of a detergent composition A; b) washing the cleaning textiles soiled in step a) by mechanically and automatically washing in a use solution of the detergent composition A; c) wet wiping a surface with cleaning textiles obtained in step b) and wetted with the use solution of the detergent composition A; d) optionally repeating steps b) and c) at least once. The present invention further refers to the use of a detergent composition A for manual surface cleaning involving the use of cleaning textiles and for washing said cleaning textiles soiled by said manual surface cleaning, wherein the detergent composition A comprises at least one surfactant and the washing of said cleaning textiles is carried out in the presence of a preserving agent or preserving composition. The present invention also provides a system comprising the following a) to c): a) detergent composition A; b) one or more cleaning textiles; c) a portable washing machine or countertop washing machine.
Patent CA-2959467-C (CA)
Inventor: YAMAGUCHI TAKASHI
IPC: G02B6/02
Filed: 2015-08-19
Granted: 2019-03-12
Abstract: An optical fiber connection structure is provided, in Which a first optical fiber and a second optical fiber, which is optically connected to the first optical fiber via a solid refractive index-matching material which is provided on a tip surface of the first optical fiber, are held and fixed between a base member and a cover member, a tip of the second optical fiber is disposed so as to come into contact with the solid refractive index matching material or separated from the solid refractive index-matching material, and the entire solid refractive index matching material and the tip of the second optical fiber are disposed in a liquid refractive index matching agent which is provided between the base member and the cover member.
Patent CA-2961757-C (CA)
Inventor: BURNETT DANIEL R
IPC: A61B5/20
Filed: 2015-09-28
Granted: 2023-10-03
Abstract: L'invention concerne des systèmes, des dispositifs et des procédés pour détecter des données physiologiques et drainer et analyser des fluides corporels, qui sont aptes à détecter des données physiologiques sur la base de capteurs incorporés dans un cathéter conçu pour résider dans l'un quelconque d'un tractus urinaire, d'un tractus gastro-intestinal, d'un emplacement rectal, d'un espace pré-péritonéal, d'un espace pleural ou d'une autre cavité corporelle. Les dispositifs aident à vider la vessie, mesurer une sortie d'urine et divers paramètres d'urine, tels que la tension en oxygène, la conductance d'urine et la gravité spécifique d'urine, surveiller une fonction rénale, analyser des paramètres d'urine, y compris le contenu d'urine, comprenant la présence d'infection, et suivre et/ou réguler l'administration de fluide.
Patent CA-2961834-C (CA)
Title: Conception coaxiale pour unite secondaire
Inventor: FLURI ROLF
IPC: G01R15/06
Filed: 2015-07-15
Granted: 2019-08-06
Abstract: L'invention concerne un diviseur de tension RC (1) comprenant une partie secondaire (2) reliée à une partie primaire (3), la partie secondaire (2) comprenant une construction coaxiale.
Patent CA-2965877-C (CA)
Inventor: KLOTZ FRANCK
IPC: G07C3/00
Filed: 2014-10-30
Granted: 2023-07-04
Abstract: Méthode de suivi en temps réel d'une ligne de traitement (1) comprenant une succession de postes (2) de traitement de produits, ainsi qu'une pluralité d'accumulateurs (3) entre lesdits postes (2), ladite méthode comprenant surveiller en temps réel le fonctionnement de la ligne de traitement (1), ainsi que rendre compte de ce fonctionnement sur un moyen d'affichage (5). Méthode caractérisée par une étape consistant essentiellement à calculer une durée pour un poste (2) de traitement, ladite durée étant calculée de façon additive à partir du temps d'accumulation (TA) que représente l'état instantané de l'accumulateur (3) ou de chaque accumulateur (3) présent entre ledit poste (2) et un autre poste (2) prédéfini de la ligne de traitement (1), dit poste de référence (4), et par une étape consistant essentiellement à afficher cette durée sur un moyen d'affichage (5). L'invention a aussi pour objet un dispositif adapté. Application notamment aux lignes multipostes de conditionnement de bouteilles et flacons.
Patent CA-2968801-C (CA)
Title: Frein dynamique a poignee rotative
Inventor: FLEMING WESLEY
IPC: B62B5/04
Filed: 2017-05-31
Granted: 2022-10-11
Abstract: Un porte-bébé (100) comprend un guidon (200) et un actionneur de frein rotatif (300) disposé le long dun axe longitudinal du guidon (200). Un premier câble (302) ayant une première et une deuxième extrémité est couplé à lactionneur de frein rotatif (300). Un premier frein de roue (105) dune première roue (104a) est couplé à la première extrémité du premier câble (302). La rotation de lactionneur de frein rotatif (300) autour de laxe longitudinal du guidon (200) active le premier frein de roue (105).
Patent CA-2969622-C (CA)
Title: Apparatus for and method of estimating dimensions of an object associated with a code in automatic response to reading the code
Inventor: WILLIAMS JAY J
IPC: G01B21/04
Filed: 2015-10-16
Granted: 2019-08-06
Abstract: Dimensions of an object associated with an electro-optically readable code are estimated by aiming a handheld device at a scene containing the object supported on a base surface. A scanner on the device scans the scene over a field of view to obtain a position of a reference point of the code associated with the object, and reads the code. A dimensioning sensor on the device captures a three-dimensional (3D) point cloud of data points of the scene in automatic response to the reading of the code. A controller clusters the point cloud into data clusters, locates the reference point of the code in one of the data clusters, extracts from the point cloud the data points of the one data cluster belonging to the object, and processes the extracted data points belonging to the object to estimate the dimensions of the object.
Patent CA-2973457-C (CA)
Title: Reamer guide systems
Inventor: ROCCI MIRKO
IPC: A61B17/16
Filed: 2011-01-28
Granted: 2020-10-27
Abstract: A reamer guide system is described in various embodiments, the reamer guide including a guide base having a base body that is configured to be positioned adjacent to at least two bones, wherein the at least two bones are selected from the group consisting of a lunate, a capitate, a hamate, and a triquetrum, the guide base defining a guide aperture that extends through the base body and is configured to receive a reamer and directs the reamer towards the at least two bones when the base body is positioned adjacent to the at least two bones, and at least two bores that extend through the base body at a location so as to be aligned with each of the at least two bones, respectively, when the base body is positioned adjacent to the at least two bones.
Patent CA-2973877-C (CA)
Title: Secure storage box for autorack car
Inventor: HUCK KENNETH W
IPC: B61D3/18
Filed: 2017-07-18
Granted: 2023-09-19
Abstract: According to some embodiments, a railcar comprises a railcar door for accessing an interior of the railcar, and a storage box comprising an access opening. The storage box is disposed such that when the railcar door is in a closed position, the railcar door prevents access to the storage box access opening, and when the railcar door is in an open position, the storage box access opening is accessible. In some embodiments the railcar door comprises a double door, and the storage box comprises a first portion coupled to a first door and a second portion coupled to a second door and adjacent to the first portion of the storage box. The first portion of the storage box prevents access to the second portion when the double doors are in a closed position. In some embodiments, the storage box is recessed into the railcar floor beneath the railcar door.