Patent SG-11201810816Q-A (SG)
Title: Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto
Inventor: PARINDER LEIF KARLSSON
IPC: A61K48/00
Filed: 2017-06-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111011101111111101011111001111110101111101011111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/214175 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07K 14/52 (2006.01) A61K 31/7088 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A61K 47/02 (2006.01) A61K 39/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 48/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/US2017/036188 Published: — with international search report (Art. 21(3)) (22) International Filing Date: — before the expiration of the time limit for amending the 06 June 2017 (06.06.2017) claims and to be republished in the event of receipt of (25) Filing Language: English amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (26) Publication Language: English (30) Priority Data: 62/346,979 07 June 2016 (07.06.2016) US 62/411,091 21 October 2016 (21.10.2016) US 62/432,005 09 December 2016 (09.12.2016) US (71) Applicant: MODERNATX, INC. [US/US]; 200 Technol- ogy Square, Cambridge, Massachusetts 02139 (US). (72) Inventors: PARINDER, Leif Karlsson; AstraZeneca AB, SE-431 83 Molndal (SE). FRITSCHE DANIELSON, Regina Desiree; AstraZeneca AB, SE-431 83 Molndal (SE). HANSSON, Kenny Mikael; AstraZeneca AB, SE-431 83 Molndal (SE). GAN, Li Ming; AstraZeneca AB, SE-431 83 Molndal (SE). CLARKE, Jonathan; Karolin- ska Institutet, 35 Berzelius Vag, 171 65 Stockholm (SE). EGNELL, Ann-Charlotte Eva; AstraZeneca AB, SE-431 83 Molndal (SE). CHIEN, Kenneth Randall; Karolinska Institutet, 35 Berzelius Vag, SE 171 65 Stockholm (SE). Agent: CHAPMAN, Ernest F. et al.; Finnegan, Hender- son, Farabow, Garrett & Dunner, LLP, 901 New York Av- enue, N.W., Washington, District of Columbia 20001-4413 (74) (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) ,_ 1 (84) ir) IN Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 71' 1-1 ei N (54) Title: MODIFIED RNA ENCODING VEGF-A POLYPEPTIDES, FORMULATIONS, AND USES RELATING THERETO 1-1 0 (57) : The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the ei modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in 0 treating subjects suffering from diseases responsive to VEGF-A therapy.