Patent SG-11201807903T-A (SG)
Title: A bioreactor system and method thereof
Inventor: Patel Ravindrakumar Dhirubhai
IPC: C12M3/00
Filed: 2016-10-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111011110110110111011111101111011111 International Bureau 0.. .... .. ..... ..or::,,,, (10) International Publication Number (43) International Publication Date WO 2017/158611 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12M 1/00 (2006.01) C12M 1/12 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, C12M 3/00 (2006.01) C12M 1/02 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/IN2016/050336 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (22) International Filing Date: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 4 October 2016 (04.10.2016) ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 201621008865 14 March 2016 (14.03.2016) IN TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventor; and LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant : PATEL, Ravindrakumar Dhirubhai SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [IN/IN]; B-202, Royal Residency, Nr. Vandematram City, GW, KM, ML, MR, NE, SN, TD, TG). Nr. Gota Railway Crossing, Gota, Ahmedabad, Gujarat 382421 (IN). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) (74) Agents: ACHARYA, Rajeshkumar H. et al.; H K ACHARYA & COMPANY, Advocates•Patent & Trade- — as to applicant's entitlement to apply for and be granted a — marks Attorneys, HK Avenue, 19, Swastik Society Nav- patent (Rule 4.17(U)) — rangpura, Ahmedabad, Gujarat 380009 (IN). — of inventorship (Rule 4.17(iv)) Designated States indicated, (81) (unless otherwise for every Published: kind AE, AG, AL, AM, of national protection available): AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, — with international search report (Art. 21(3)) = BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = = = (54) Title: A BIOREACTOR SYSTEM AND METHOD THEREOF = N. 2 = = ... ..... .......... = = 4\: '4k.,,,,, 1(b) i I/ 1 . :a ---- 19 = 5 3-, st, \ Il ,0.--,........ ‘‘k, Il 1-1 Fig.1 (a) GC iln (57) : The present invention relates to bioreactor system and method thereof wherein support matrix (2) comprises at last 1-1 --... one central shaft and plurality of peripheral shaft being radially surrounds central shaft. Arrays of discs (11) are mounted along the IN 1-1 shaft by defining interspatial vicinities between two successive plates. Thus, discs mounted on peripheral shafts are rotated within C the interspatial vicinity of discs of central shaft to ensures sufficient mixing and avoid stagnant fluidic zones which is created when N discs are mounted closely apart from each other on shafts. Further, plurality of deflector vanes that are axially provided along the Olength of the central shaft to redirect substantially co-axial direction fluid flow into interior of culture vessel and more specifically ,1. towards the central axis. Thus, bioreactor system provides scalable and disposable bioreactor with efficient mixing and homogen- eous conditions and thereby supports high density growth and maintenance of cells and other biological material.