Patent EP-2202232-A1 (EP)
Inventor: GIULIO MATASSA VICTOR
IPC: A61P25/00
Filed: 2008-12-26
Abstract: New derivatives of general formula (I), or pharmaceutically acceptable salts or N-oxides thereof wherein, 
A is selected from the group consisting of -N-, -O- and -S-; 
B and C are independently selected from the group consisting of-N- and -O-, with the proviso that at least two of A, B and C are nitrogen atoms; 
G 1  is selected from the group consisting of -CH 2 -, -NH- and -O-; 
G 2  is selected from the group consisting of -NR 4 - and -O-; 
R 1  represents: 
➢ a 8 to 10 membered bicyclic N-containing heteroaryl group optionally substituted with a C 1-4  carboxyalkyl group or a C 1-4  aminoalkyl group, 
➢ a pyridyl group optionally substituted with one or more substituents selected from hydroxy groups, C 1-4  alkyl groups, C 1-4  carboxyalkyl groups, C 1-4  haloalkyl groups, C 1-4  alkoxy groups, amino groups, C 1-4  aminoalkyl groups and C 1-4  aminoalkoxy groups, 
➢ a pyridone group substituted with one or more C 1-4  alkyl groups; C 1-4  haloalkyl groups or C 1-4  aminoalkyl groups, or 
➢ a group of formula:
     
wherein: 
• R a  represents a hydrogen atom, a halogen atom, a C 1-4  alkyl group, C 3-4  cycloalkyl group or a -CF 3  group; 
• R b  represents a hydrogen atom, a halogen atom, a C 14  alkyl group, a -CF 3  group or a C 1-4  alkoxy group; 
• R d  represents a hydrogen atom, a C 1-4  alkyl group or a C 1-4  alkoxy group; 
• R c  represents: 
○ a hydrogen atom, a C 1-4  hydroxyalkyl group, a C 1-4  aminoalkyl group which is optionally substituted with one or more substituents selected from halogen atoms, hydroxy groups and -CF 3  groups; 
○ a 4 to 6-membered saturated N-containing heterocyclic ring optionally substituted with a C 1-2  carboxyalkyl group; 
○ -(CH 2 ) (0-4) -C(O)OR', -(CH 2 ) (0-4) -C(O)NR'R", -(CH 2 ) (0-4) -NHC(O)R", -S(O) 2 NR'R", -O-(CH 2 ) (2-4) NR'R", -O-(CH 2 ) (1-4) C(O)OR", -O-(CH 2 ) (1-4) -C(O)NR'R", -(CH 2 ) (0-4) -NR'R", -(CH 2 ) (0-4) -CONHS(O) 2 R', -(CH 2 ) (0-4) -NHS(O) 2 R' or -(CH 2 ) (0-3) -N H-(CH 2 ) (1-3) -(NH) (0-1) S(O) 2 R' wherein, 
■ R' represents a hydrogen atom or a C 1-4  alkyl group, 
■ R" represents a hydrogen atom, a C 1-4  alkyl group, a C 3-4  cycloalkyl group, a C 1-4  carboxyalkyl group, a C 1-4  haloalkyl group, a C 1-4  hydroxyalkyl group or a 6 membered, saturated N-containing heterocyclic ring, or 
■ R' and R" together with the nitrogen atom to which they are attached from a 4 to 6 membered heterocyclic group which contains, as heteroatoms, one N atom and, optionally, one further atom selected from N and O, and which is optionally substituted with a carboxy or a C 1-4  carboxyalkyl group, 
 
or R c  together with R d  form a C 5-6  cycloalkyl group optionally substituted by a -NHR f  group, wherein R f  is selected from the group consisting of a hydrogen atom and a carboxymethyl group; 
 
R 2  and R 3  are independently selected from the group consisting of hydrogen atoms, halogen atoms and C 1-4  alkyl groups; and 
R 4  is selected from the group consisting of a hydrogen atom, a phenyl group, a C 3-4  cycloalkyl-C 1-4  alkyl group, C 1-4  aminoalkyl group, C 1-4  haloalkyl group and a linear or branched C 1-4  alkyl group which is optionally substituted by a phenyl or a pyridyl group.