Patent SG-11201805331Q-A (SG)
Title: Cocrystal, production method thereof, and medicament containing cocrystal
Inventor: Kimoto Koya
IPC: C07D401/14
Filed: 2016-12-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPOIPCT (10) International Publication Number WO 2017/111179 A1 (51) International Patent Classification: C07D 401/14 (2006.01) A61K31/4725 (2006.01) A61P 35/00 (2006.01) C07C 65/05 (2006.01) C07C 65/10 (2006.01) C07C 55/08 (2006.01) C07C 57/145 (2006.01) C07C 59/245 (2006.01) C07C 59/265 (2006.01) C07C 59/54 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/JP2016/089224 22 December 2016 (22.12.2016) English (30) Priority Data: 2015-252658 24 December 2015 (24.12.2015) English JP (71) Applicant: TAKEDA PHARMACEUTICAL COM­ PANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: KIMOTO, Koya; c/o TAKEDA PHARMA­ CEUTICAL COMPANY LIMITED, 26-1, Muraoka-Hi- gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). YAMAMOTO, Mitsuo; c/o TAKEDA PHARMACEUT­ ICAL COMPANY LIMITED, 26-1, Muraoka-Higashi 2- chome, Fujisawa-shi, Kanagawa, 2510012 (JP). KITAYAMA, Masato; c/o TAKEDA PHARMACEUTIC­ AL COMPANY LIMITED, 17-85, Jusohonmachi 2- chome, Yodogawa-ku, Osaka-shi, Osaka 5320024 (JP). SAWAI, Yasuhiro; c/o TAKEDA PHARMACEUTICAL COMPANY LIMITED, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka-shi, Osaka 5320024 (JP). HO- HOKABE, Miyuki; c/o TAKEDA PHARMACEUTICAL COMPANY LIMITED, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka-shi, Osaka 5320024 (JP). IWATA, Kentaro; c/o TAKEDA PHARMACEUTICAL COM­ PANY LIMITED, 26-1, Muraoka-Higashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). (74) Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- ku, Osaka-shi, Osaka 5410044 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 0\ l> o CJ (54) Title: COCRYSTAL, PRODUCTION METHOD THEREOF, AND MEDICAMENT CONTAINING COCRYSTAL (57) : The present invention provides a cocrystal of (S)-3-(l-((l-acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-lH-l,2,4- triazol-5(4H)-one and an organic acid capable of forming a cocrystal with the compound. Specific cocrystals prepared are cocrystals with gentisic acid, salicylic acid, maleic acid, malonic acid, malic acid, mandelic acid and citric acid.