Patent SG-11201808705X-A (SG)
Title: Particle manipulation
Inventor: AI YE
IPC: G01N29/02
Filed: 2017-04-04
Abstract: IDT Micro-pillar 25 LiNb0 3 Substrate 10 15 Pressure Y-displacement (kPa) (nm) 40 0.2 20 0.1 0 0 -20 -40 -0.2 • LiNbO, Substrate TSAW W O 20 1717 / 6 211 Al PDMS (b) Fluid Figure 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/176211 Al 12 October 2017 (12.10.2017) WIPO I PCT 1111111111111101110111111111110101111101110101111111101110111011111111111110111111 (51) International Patent Classification: G01N 29/02 (2006.01) BOIL 3/00 (2006.01) (21) International Application Number: PCT/SG2017/050192 (22) International Filing Date: 4 April 2017 (04.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201602719V 6 April 2016 (06.04.2016) SG (71) Applicant: SINGAPORE UNIVERSITY OF TECHNO- LOGY AND DESIGN [SG/SG]; 8 Somapah Road #05- 302, Singapore University Of Technology And Design, Singapore 487372 (SG). (72) Inventors: AI, Ye; Block 53, Changi South Avenue 1, #10-10, Singapore 485996 (SG). MA, Zhichao; Block 57 Changi South Avenue 1, #04-71, Singapore 485998 (SG). (74) Agent: AMICA LAW LLC; 30 Raffles Place, #14-01 Chevron House, Singapore 048622 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: PARTICLE MANIPULATION (57) : The present invention relates to the manipulation and, more particularly, to the sorting of particles. Still more particularly, the present in- vention relates to the use of acoustic waves, in- cluding surface acoustic waves, for the manipula- tion and sorting of particles. In an example, the present invention may be used for the sorting of cells. In an aspect of the invention, there is provided a device for manipulating a particle in a fluid suspension, the device comprising: (a) a sub- strate having a surface; (b) an acoustic source con- figured to generate and deliver an acoustic wave within a region of the substrate surface; and (c) a pillar disposed on the surface of the substrate and the pillar is configured to receive a channel, the channel configured to receive the fluid suspension, wherein the acoustic wave delivered within the re- gion of the substrate surface is delivered to the flu- id suspension in the channel through the pillar. A method using the device of the invention is also disclosed.