Patent SG-11201804714X-A (SG)
Title: Electrode integration into organs on chip devices
Inventor: HENRY OLIVIER
IPC: B01L3/00
Filed: 2016-12-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 111111111111110 III OE III OE III II III 11111111111111111111 OE HIRE 1111111H (10) International Publication Number WO 2017/106727 Al WIPO I PCT (43) International Publication Date 22 June 2017 (22.06.2017) (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 5/07 (2010.01) G01N 27/40 (2006.01) kind of national protection available): AE, AG, AL, AM, C12M 3/04 (2006.01) GO1N 33/50 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BOIL 3/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: PCT/US2016/067294 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 16 December 2016 (16.12.2016) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, English (25) Filing Language: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (26) Publication Language: (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/268,454 16 December 2015 (16.12.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/297,659 19 February 2016 (19.02.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: PRESIDENT AND FELLOWS OF HAR- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VARD COLLEGE [US/US]; 17 Quincy Street, Cam- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, bridge, Massachusetts 02138 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: HENRY, Olivier; 519 Washington Street, Apt. GW, KM, ML, MR, NE, SN, TD, TG). 15, Brookline, Massachusetts 02446 (US). VAN DER MEER, Andries; Renbaanstraat 18, 7523 ZW Enschede Declarations under Rule 4.17: (NL). INGBER, Donald, E.; 162 W. Canton St., Boston, as to applicant's entitlement to apply for and be granted a Massachusetts 02118 (US). patent (Rule 4.170) (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, as to the applicant's entitlement to claim the priority of the 70 W. Madison St., Suite 3500, Chicago, Illinois 60602- earlier application (Rule 4.17 (iii)) 4224 (US). [Continued on next page] (54) Title: ELECTRODE INTEGRATION INTO ORGANS ON CHIP DEVICES 120 c 134 1 130 32 109 I 107 126 128 126 128 121 122 104 101 124 102 133 108 106 127 110 108 W O 20 17 / 1067 27 Al 106 129 FIG. lE (57) : A method of fabricating electrodes includes foiining a first metallic film layer on an upper surface of a first material substrate, and attaching a first polymeric layer to the upper surface of the first material substrate to fon]] a first opened microchannel. The method further includes forming a second metallic film layer on a portion of a lower surface of a second material substrate, and attaching a second polymeric layer to the lower surface of the second material substrate to form a second opened microchannel. The method also includes attaching the first opened microchannel to a bottom side of the membrane and the second opened microchannel to the top side of the membrane. The first metallic film layer and the second metallic film layer each constitute transparent electrodes and are positioned with the membrane therebetween. WO 2017/106727 Al MIDEDIMOMONIIMOID130101101100MOIMMOVOIMIE Published: — before the expiration of the time limit for amending the — with international search report (Art. 21(3)) claims and to be republished in the event of receipt of amendments (Rule 48.2(h))