baber/WOPTO huggingface dataset:
Patent DO-P2009000201-A (DO)
Title: Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h, 4h, 6h)carbaldehido como inhibidores pkc
Inventor: NUKUI SEIJI
IPC: C07D487/04
Filed: 2009-08-07
Abstract: La presente invención se refiere a compuestos y sales farmaceuticamente aceptables de formula A y B: En las que A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 son como se han definido anteriormente. La invención también se refiere a composiciones farmacéuticas que comprenden los compuestos y sales farmaceuticamente aceptables y a procedimientos de tratamiento de la diabetes mellitus y sus complicaciones, cáncer, isquemia, inflamación, trastornos del sistema nervioso central, enfermedad cardiovascular, enfermedad de Alzheimer y presión de enfermedad dermatológica, enfermedad virales, trastornos inflamatorios o enfermedades en las que el hígado es un órgano diana.
Patent DO-P2013000039-A (DO)
Title: Composiciones de anticuerpo anti-vegfr-3
Inventor: PYTOWSKI BRONISLAW
Filed: 2013-02-14
Abstract: La presente invención se refiere a anticuerpos monoclonales antiVEGFR-3, composiciones farmacéuticas que contienen los anticuerpos y usos de los anticuerpos en el tratamiento de enfermedades.
Patent DO-P2019000312-A (DO)
Title: Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas
Inventor: MICHAEL P LISANTI
IPC: C07D209/04
Filed: 2019-12-19
Abstract: La presente descripción se refiere a compuestos que se enlazan a por lo menos una de ACAT1/2 y OXCT1/2 e inhiben la producción mitocondrial de ATP, referidos en este documento como mitocetoscinas. Se dan a conocer métodos de prospección de compuestos por la inhibición mitocondrial y propiedades anticancerosas. También se describen métodos para usar mitocetoscinas para prevenir o tratar cáncer, infecciones bacterianas y levadura patógena, así como también métodos para usar mitocetoscinas para proporcionar beneficios anti-envejecimiento. También se dan a conocer compuestos de mitocetoscina específicos.
Patent EC-SP10010432-A (EC)
Title: Método para la mejora de la recuperación de hidrocarburos pesados
Inventor: HART PAUL R
IPC: E21B43/22
Filed: 2010-08-30
Abstract: Las aminas o amoniaco y aminas se pueden utilizar para mejorar la recuperación de hidrocarburos pesados. Las aminas o amoniaco y aminas únicamente o con agua, vapor o un disolvente de petróleo se combinan con los hidrocarburos pesados en favor del transporte de los hidrocarburos pesados. Las aminas o amoniaco y aminas se pueden inyectar hacia el fondo de pozo o mezclado con hidrocarburos pesados que contengan un mineral en la superficie, de manera opcional con agua o vapor. El amoníaco se puede usar solo con vapor de alta calidad.Cabe destacar que este resumen se ofrece para dar cumplimiento a la norma que exige un resumen que permita a un buscador o a otro lector para determinar rápidamente el tema de la descripción técnica. Se afirma en el entendimiento de que no serán utilizados para interpretar o limitar el alcance o el sentido de las reivindicaciones
Patent EE-200200660-A (EE)
Inventor: GERONI MARIA CRISTINA ROSA
IPC: A61K33/243
Filed: 2001-06-20
Abstract: Compounds which are alpha-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.
Patent GB-189702268-A (GB)
Title: An Improved Medicinal Preparation.
Inventor: COATES EDWIN
Filed: 1897-01-28
Granted: 1897-12-04
Abstract: 2268. Coates, E. Jan. 28. Dentifrices. - Carbolic-acid crystals, spirits of camphor, oil of cinnamon, and oil of gaultherium are mixed together in specified proportions.
Patent GB-189702277-A (GB)
Title: Improvements in Hermetically Sealed Sheet Metal Cans.
Inventor: CLERIHEW GEORGE WILLIAM
Filed: 1897-01-28
Granted: 1897-04-03
Abstract: 2277. Clerihew, G. W. Jan. 28. Cans, opening.-The vertical rim or flange b of can lids B are made with a bead 4 forming a shoulder 5 against which the top edge a of the can bears. A weakening or tearing line b<11> is formed on the inside or outside of the can, which is opened by pulling the projecting tongue b<1>. The lid may be made without the bead 4 as shown in Fig. 5.
Patent GB-189703957-A (GB)
Title: Improvements in the Manufacture or Preparation of Dichloroxypurine.
Inventor: JOHNSON JAMES YATE
Filed: 1897-02-13
Granted: 1897-12-11
Abstract: 3957. Johnson, J. Y., [Boehringer & S÷hne, C. F.]. Feb. 13. Dichloroxypurine.-Dichloroxypurine is produced by heating a dry salt of uric acid, such as the acid potassium, sodium, ammonium, magnesium, calcium, or barium salt, or uric acid itself, with phosphorus oxychloride in a closed vessel at 160‹-175‹ C. After distilling off the remaining phosphorus oxychloride, the residue is purified by treatment with nitric acid and forming the ammonium salt, or by recrystallizing from alcohol and decolorizing with nitric acid. Dichloroxypurine differs from uric acid in its stability against oxidizing-agents, such as nitric acid, and in forming a stable silver salt. On methylation it yields Fischer's dichloroxydimethylpurine, and is therefore regarded as 2 ; 6- dichlor-8-oxypurine.
Patent GB-189705488-A (GB)
Title: Improvements in and connected with Pipes for Smokers.
Inventor: WATSON GEORGE WILLIAM
Filed: 1897-03-02
Granted: 1897-04-17
Abstract: 5488. W a t s o n, G. W. March 2. Tobacco pipes.-T h e bowl a of a tobacco pipe is provided with a removable inner bowl c, which is perforated at the bottom. The supplementary bowl c may be attached to the bowl a by a thread b or by other means.
Patent GB-189706800-A (GB)
Title: An Improved Method of and Means for the Production of Motive Power by the Combustion of Oil, or Gas, or Solid Fuel
Inventor: MARTIN HAROLD MEDWAY
Filed: 1897-03-16
Granted: 1898-02-26
Abstract: 6800. Martin, H. M. March 16. Air and gas engine furnaces. - Relates to apparatus for producing a jet of gas of high velocity for driving a turbine, and consisting of a furnace or combustion chamber into which gas, oil, or powdered fuel is injected through a pipe h, and air to support combustion through openings f. A steam injector g forces in the air for combustion and maintains a high pressure in the chamber, so that a jet of high velocity passes out by the orifice c. The chamber is lined with refractory material e. The steam for the injector g may be generated in a coil passing through the furnace, and when oil fuel is used it may be vaporized in a similar manner.
Patent GB-189707145-A (GB)
Title: A New or Improved Device for Collecting Fur or Deposit in Kettles and Boilers.
Inventor: OAKFORD JOHN WILLIAM
Filed: 1897-03-19
Granted: 1897-06-05
Abstract: 7145. Oakford, J. W. March 19. Drawings to Specification. Incrustation, removing. - A series of plates, radiating star-wise, are mounted upon a weighted base and immersed in the kettle, boiler, or other vessel from which the fur or deposit is to be collected.
Patent GB-189713899-A (GB)
Title: Improvements in the Manufacture of Incandescing Media for Lighting Purposes.
Inventor: LANGHANS RUDOLF
Filed: 1897-06-05
Granted: 1898-04-16
Abstract: 13,899. Langhans, R. June 5. Incandescent gas lamps.-Relates to the methods of manufacturing incandescent bodies, described in Specifications No. 14,845, A.D. 1896, and No. 501, A.D. 1897. Such bodies are made from vanadiferous zirconia or vanadiferous thoria and an alkali salt. They may be made by adding, to an aqueous solution of zirconium or thorium nitrate, calcium hydroxide or other suitable alkaline-earth oxide, hydrate, carbonate, or formate. In another method, a mixed vanadiferous solution of zirconium or thorium nitrate and an alkaline-earth nitrate is combined with ammonia, aniline, or an organic base, or with carbonate or formate or zirconium or thorium ; or a vanadiferous solution of an alkalineearth salt is added to an aqueous solution of zirconium or thorium oxychloride. Strontium or barium oxide may be used in addition to the calcium oxide referred to above.
Patent GB-189715949-A (GB)
Title: Improvements in the Suspension of Motors and the Transmission Gearing for Motor Road Vehicles.
Inventor: POPE ALBERT AUGUSTUS
Filed: 1897-07-05
Granted: 1897-08-07
Abstract: 15,949. Pope, A. A. July 5. Motor road vehicles. -The carriage body x, Fig. 1, and motor platform y are independently supported on the underframing a, the former on transverse springs a<4>, a<4>, and the latter on springs a<5>. The form of gearing preferred for transmitting motion from the motor shaft m to the driving - axle c<12> is shown in Fig. 3. This is arranged and supported so as not to be effected by the motion of the motor platform on its springs. The f i r s t intermediate shaft m<2> is supported in bearings o n t h e platform, and the second m<11> by links m<12>, m<13>, by which it is kept at a fixed distance from each of the shafts m<2> and c<12>,
Patent GB-189720918-A (GB)
Title: Improvement in Wheel Tires for Bicycles.
Inventor: ROSS ERNEST SYDNEY
Filed: 1897-09-11
Granted: 1897-10-30
Abstract: 20,918. Ross, E. S. Sept. 11. Tyres, pneumatic, preventing puncture of. Between the inner and outer tubes of a pneumatic tyre is situated a puncture-proof device, consisting of a backing, preferably of wire gauze, to which are attached a series of overlapping plates e'. Each plate is provided with two holes e' through which pass the attaching-loops e<3>.
Patent GB-189722985-A (GB)
Title: Handle Bar for Cycles in General.
Inventor: VANN THOMAS
Filed: 1897-10-07
Granted: 1898-01-15
Abstract: 22,985. Vann, T. Oct. 7. Handle bars are constructed so that the position of the handles may be adjusted &c. Two curved arms 8 carrying handles 9 are formed at their ends into split clamping-sockets 11, 12 and adjustably fixed on to the ends of a T-piece 6, 7. The ends of the bar 7 are provided with holes 10 with which engage the ends 14 of springs 13 encircling the clamping-bolts 12. Or the ends of the bar may be serrated and lugs formed on the clips. Handles 9<a> may be placed on the bar 7.
Patent GB-189723875-A (GB)
Title: Improvements in or relating to the Manufacture of Lactose or Sugar of Milk.
Inventor: HIGGINS HUBERT
Filed: 1897-10-16
Granted: 1898-09-03
Abstract: 23,875. Higgins, H. Oct. 16. Glucose and like carbohydrates.-The waste liquid resulting from the precipitation of caseinogen, by means of acids, from separated milk is neutralized by adding carbonate of lime, and is then treated according to ordinary methods for the production of lactose. Any suitable substance capable of forming a soluble salt with the acid may be employed instead of carbonate of lime.
Patent GB-189724023-A (GB)
Title: Improvements in the Method of Securing or Fastening the Ends of Solid Rubber Cords.
Inventor: WHITTY WILLIAM REGINALD READ
Filed: 1897-10-19
Granted: 1898-09-24
Abstract: 24,023. Whitty, W. R. R. Oct. 19. Couplings for cords. On the end of an indiarubber cord, which has been previously stretched, is placed a tapered metal or other tube b, Figs. 1 and 2, and, inside this tube, a tapered tube c is made in two or more sections. The tube b is connected to a handle or other fitting by a pin passing through holes b<1>, b<1> or by a flange b<2>, as shown in Fig. 3.
Patent GB-189801521-A (GB)
Title: Improvements in Water Tube Steam Generators.
Filed: 1898-01-19
Granted: 1898-02-19
Abstract: 1521. Simpson, Strickland, & Co. and Strickland, F. Jan. 19. Water-tube boilers.-The tubes of a boiler of the Thornycroft type are arranged in such a way that any single tube can be withdrawn and replaced without a disturbance of other tubes. In addition, to ensure a better distribution of the heating gases, some of the water-tubes are crowded together below the funnel. Fig. 4 shows one form of boiler with the improvements applied thereto, and Fig. 6 an enlarged developed view of part of the lower water drum B. From Fig. 6 it will be seen that the spaces s between the straight rows of the tubes T<1> &c. are sufficiently large to allow tubes to be taken therethrough without disturbance to others. To crowd the tubes below the uptake, the tubes p in that position are raised into a line with the outermost row of tubes.
Patent GB-189804616-A (GB)
Title: A Shoe for Horses, Donkeys, or other Animals, to be Fixed without Nails.
Inventor: PRICE HENRY ADDIS
Filed: 1898-02-24
Granted: 1898-04-02
Abstract: 4616. Price, H. A., and Payne, E. Feb. 24. Right of patent relinquished. Fixing.-The shoe A is fixed by clips B and screws D. The clips are dovetailed &c. to the shoe, and have sharp prongs to enter the hoof; the screws pass through the shoe and clips and also enter the hoof.
Patent GB-189808500-A (GB)
Title: Improvements in and relating to the Machinery for Inserting Metallic Fastenings in Making Boots, Shoes, and the like.
Inventor: BROOKES ALFRED GEORGE
Filed: 1898-04-12
Granted: 1899-04-12
Abstract: 8500. Brookes, A. G., [Brooks, J. W.]. April 12. Nailing.-Relates to improvements on the machine described in Specification No. 1492, A.D. 1893. The wire grippers consist of three serrated wheels h<10>, Figs. 10 and 12, having conical journals rotating in the annular recess F<2>. When the sleeve F is depressed by the ring D<10> the feedwheels are pressed inwards to grip the wire. As shown in Fig. 1, the horn-depressing rod B<8> is pivoted to a toothed bar d<2> engaging a similarly-toothed bar d<6> coupled to the horndepressing lever in the base of the standard. To start the wire feeding and cutting mechanism, the operator by means of a treadle raises the lever f<7> and by means of a spring f<6> rocks the vertically-reciprocated latch e<22>. The part t or t<1> then strikes the projection e<27> or e<28> on the lever e<26> shown separately in Fig. 4<a>. By this means the stop e<31> is withdrawn from the lever B<9> and the lever f<22> is rotated to bring its upper end 3 in the path of the projections C', C<2>. These projections depress the lever f and the lever C to which it is pivoted, and operate the wire cutters. At the same time the lever B<9> drops so that the roller B<10> comes into contact with a cam actuating the feed-mechanism. The movement of the lever e<26> also actuates the block g<9> to allow the measuring-rod G<3> to come into action. The pin securing the wire spool in the top of the spindle, as shown in Fig. 9<a>, raises a slide 85 so that it clears a projection 86 when inserted to the required distance. If not so inserted the spindle cannot be rotated.
Patent GB-189819851-A (GB)
Title: Improvements in Railway and Tramway Wheels.
Filed: 1898-09-19
Granted: 1899-02-04
Abstract: 19,851. Hyde, R., and Tozer Stanton Wheel Co. Sept. 19. Making wheels.-Relates to disc wheels in which the discs A are spaced on the hub by a ring C, and consists in drilling a number of holes E on the inside of the ring C to receive metal from the hub B during the manufacture of the latter, and thus to bind the two parts together.
Patent GB-189826513-A (GB)
Title: Improvements in and in connection with Bungs for Casks.
Inventor: ASH ARTHUR DAVID
Filed: 1898-12-15
Granted: 1899-10-21
Abstract: 26,513. Ash, A. D. Dec. 15. Bungs; vent pegs and venting.-The threaded bushing A fitted into the bunghole of the barrel is adapted to receive a threaded bung B having an aperture for the stem of a spring vent peg or valve E, which normally covers a vent aperture G in the bung. The valve is lifted by being turned, when it rides on inclines.
Patent GB-189826644-A (GB)
Title: Improvements relating to Pipe Joints.
Inventor: PUTZEYS EMMANUEL
Filed: 1898-12-16
Granted: 1899-10-21
Abstract: 26,644. Putzeys, E. Dec. 16. Joint - making packing; spigot- and-socket joints.- Packing for spigot- and - socket and similar joints of water mains, sewers, and the like is made in the form of one or more fusible rings C. The rings are made of an insulating-composition, such as a mixture of terracotta, sulphur, and tar. Spiral metal conductors D, connected to terminals 1, 2, 3, 4, are embedded in the rings, which are inserted in the joint and fused by passing an electric current through the conductors.
Patent GB-189827203-A (GB)
Title: Improvements in and connected with Engine-valves.
Inventor: STUMPF JOHANN
Filed: 1898-12-23
Granted: 1899-12-16
Abstract: 27,203. Stumpf, J. Dec. 23. Valves, distributing. -Relates to the cushioning of lift or beat valves on closure. Fig. 1 shows the invention applied to double-beat admission or exhaust valves. Each seat is of stepped formation, so that, after closure, but before the valve has reached its seat, a portion of the motive fluid is enclosed in one or more annular spaces. These spaces may be connected by a passage k either with one another or with some other space. A regulating-screw l for restricting the passage may be provided.
Patent GB-189907168-A (GB)
Title: Automatic Apparatus for Feeding Sheets of Paper to Quick Printing, Calendering Machines, Foldind Machines, and the like.
Inventor: GOLBY FREDERICK WILLIAM
Filed: 1899-04-05
Granted: 1900-02-17
Abstract: 7168. Golby, F. W., [K÷nig, A.]. April 5. Feeding sheets.-Relates to means for separating and feeding sheets from a pile to printing, calendering, folding, and like machines. The sheets are fed forward from the pile to a light contactspring d<2> by means of rounded blocks H of polished horn on the ends of springs fixed to angle levers m pivoted on the ends of arms attached to a disc mounted to rotate on a shaft c. This disc is normally driven by pins on a disc, sliding on but rotating with the shaft c, and having attached to it electromagnets which draw the pins out of engagement when the electric circuit of the magnets is closed. The magnets are attracted by an iron disc fixed on the shaft c. The circuit is closed when the sheet moves the spring d<2> to the contact d<1>, and the rotation of the blocks H then stops until the circuit is broken. The angle levers m are provided with rollers running over a fixed cam O. Two sets of feedarms and blocks H &c., independently stopped by their electric circuits &c., are preferably provided on the shaft c, one operating upon each side of the sheet.
Patent GB-189907490-A (GB)
Title: Improvements in Hoisting Mechanism.
Inventor: HUNT CHARLES WALLACE
Filed: 1899-04-10
Granted: 1900-03-10
Abstract: 7490. Hunt, C. W. April 10. Cranes; winding-drums.-Fig. 1 shows a section of the winding - drums. The drums A and B, mounted loosely on the shaft H, are fitted with end bevel-wheels d and e, which mutually engage with pinions D on radial axes carried by a spurwheel C, gearing with a pinion I on the power shaft K, thrown in and out of gear by a clutch 31. Frictional clutches 25 and 30 at the outer end of the drums engage with spur-wheels 22 and 17 on the shaft K. In the case of the drum B, an intermediate pinion 23 is employed to reverse the motion. The drums A and B and the wheel C are fitted with band brakes, to lock them when the clutches are out of gear. The drums can thus be driven differentially in a number of ways. Thus, when the clutch 31 is thrown out and the clutches 25 and 30 in gear, the drums A and B are driven in opposite directions while, when the clutches 25 and 30 are out of gear and the clutch 31 in, the drums will be driven in the same direction with a relative speed depending upon the relative tensions of the two ropes. The epicyclic train may be made up of plain toothed gearing instead of the bevel gearing shown. The drum B may also be fixed on the shaft H, and the clutch 25 thus dispensed with. Fig. 6 shows the application to a jib-crane. The jib is attached to the frame at 43 by a universal joint, and is hinged at 44, so that by hauling on the rope 45, it folds into the position shown in broken lines. Fig. 12 shows diagrammatically the application to an overhead traveller. The ropes A', B<1> pass round guidepulleys to the scoop N, one acting to raise and lower it, and the other to open and close it. The scoop may also be supported by a third rope 8, which is wound round a third drum F on the axle H of the drums A and B.
Patent GB-189908218-A (GB)
Title: Improvements in Collar Studs, Solitaires and the like.
Inventor: WILSON DOUGLAS JAMES
Filed: 1899-04-19
Granted: 1899-06-10
Abstract: 8218. Wilson, D. J. April 19. Studs and solitaires.-The head C screws into the hollow stem B on the base A.
Patent GB-189910406-A (GB)
Title: Improvements in Wireless Telegraphy.
Inventor: MILLER LESLIE BRADLEY
Filed: 1899-05-17
Granted: 1900-04-14
Abstract: 10,406. Miller, L. B. May 17. Wireless telegraphy.-The coherer C, Fig. 1, is mounted on the armature B of a decohering magnet A, the contact E being in the coherer circuit and the coils of the magnet A in the relay circuit. The contacts may be shunted by selfinductances, and the receiver coils may be in parallel with the decoherer. The coherer, Fig. 2, is constructed with two electrodes separated by insulating-material, and has wires fused into one end of the glass tube. The electrodes may be side by side, or, as shown, may be concentric ; the outer tubular electrode is shown closed by a screw cap, and the tube is exhausted. The granules are preferably non-magnetic.
Patent GB-189910774-A (GB)
Title: An Improved Slide Rest for Lathes and other Machinery.
Inventor: WILKE FRIEDRICH GUSTAV
Filed: 1899-05-23
Granted: 1899-07-08
Abstract: 10,774. Wilke, F. G. May 23. Lathes.-The tool slide is made in two parts c, d with inclined surfaces. The upper part d is moved by a screw f to adjust the height of the tool e. The work blank may be clamped on the slide and operated on by a rotating cutter. The slide-rest is applicable to lathes or other metal or wood working machinery.
Patent GB-189915733-A (GB)
Title: A High Speed Engine.
Inventor: HOYT GABRIEL PURDY BETTS
Filed: 1899-08-01
Granted: 1899-09-23
Abstract: 15,733. Hoyt, G. P. B. Aug. 1. High-speed engines.-A piston B working in a cylinder A has a slot B<1>, in which work the pins D, D<1> of crank shafts F, F<1>. The shafts are parallel, and are geared together at both ends so that they rotate in opposite directions, and each of them carries a flywheel H. The arrangement tends to secure balancing, so that the engine can be run at high speeds. Motive fluid is admitted alternately to either end of the cylinder by a cam on one of the crank shafts which actuates a link I<1>, but other devices may be used. The distributing-valves are shown at C, and may either oscillate or slide. Fig. 1 shows a cylinder of large diameter having a piston of short stroke, but a longer stroke with a piston of less diameter may be used, the arrangement being the same, excepting that the piston has an enlargement in the middle to accommodate the cranks.