baber/WOPTO huggingface dataset:
Patent BR-PI1015088-B1 (BR)
Title: Peptídeo antigênico modificado, composição farmacêutica e uso dos mesmos
Inventor: ANDREA PFEIFER
IPC: C07K14/47
Filed: 2010-04-01
Abstract: peptídeo ou fragmento antigênico obtenível a partir da proteína tau,uso do referido peptídeo, anticorpo,composição farmacêutica, uso da referida composição, métodos para diagnosticar uma doença, distúrbio ou condição ou uma predisposição a doença, distúrbio ou condição associado a proteína tau, para monitorar doença a residual mínima em um paciente, para prever a responsividade de um paciente ao tratamento, e de uso dos referidos peptídeo ou fragmento, ou anticorpo ou composição farmacêutica, kit de teste, epítopo, e, linhagem celular a presente invenção diz respeito a métodos e composições farmacêuticas para uso terapêutico e diagnóstico no tratamento de doenças e distúrbios que são causados por ou associados com emaranhados neurofibrilares. em particular,a invenção diz respeito a composição farmacêutica que compreende um peptídeo antigênico, particularmente um fosfo-peptídeo antigênico que imita um fosfo-epítopo patológico de proteína tau, para o uso terapêutico e diagnóstico no tratamento de tauopatias incluindo mal de alzheimer.
Patent BR-PI1105337-B1 (BR)
Title: Processo de remoção de água solúvel e/ou emulsionada de combustíveis liquidos; material absorvente a base de homopolímero aperfeiçoado; processo de regeneração do material absorvente e dispositivo para remoção de água solúvel e/ou emulsionada de combustíveis líquidos
Inventor: MARIA REGINA WOLF MACIEL
IPC: B01J20/26
Filed: 2011-12-20
Abstract: processo de remoção de água solúvel e/ou emulsionada de combustíveis líquidos; material absorvente a base de homopolímero aperfeiçoado; processo de regeneração do material absorvente e dispositivo para remoção de água solúvel e/ou emulsionada de combustível líquidos. a presente invenção se refere a um processo de remoção de água nas suas formas livre, solúvel e emulsionada presente em combustíveis líquidos, tais como hidrocarbonetos derivados de petróleo, biocombustíveis como o biodiesel e misturas de diesel/biodiesel, utilizando materiais absorventes, tal como a poliacrilamida. a presenta invenção também se refere aos dispositivos onde o material absorventes é inserido e ao processo de regeneração do material absorvente para uso contínuo do mesmo material no dito processo de remoção de água.
Patent EA-006684-B1 (EA)
Title: Combined therapy against tumors comprising using substituted acryloyl distamycin derivatives and topoisomerase i and ii inhibitors
Inventor: GERONI MARIA CRISTINA ROSA
IPC: A61K31/7048
Filed: 2001-06-20
Abstract: The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha -bromo- and alpha -chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antineoplastic topoisomerase I or II inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
Patent EA-005088-B1 (EA)
Title: Method for detecting micro spacing by x ray method between stomatological implant and abutment
IPC: A61C8/00
Filed: 2003-05-07
Abstract: 1. A method for detecting micro spaces between stomatological implant and an abutment by an X ray method, comprising intraoral periapical radiography with an orthogonal projection of the abutment using a radiographic stent, characterized in that parallelism is provided between the implant-abutment surface and the cone of the X ray tube, X ray are produced at angles of 0, 5, 10, 15 and 20 degrees to the implant-abutment surface with different intervals of micro space 0, 100 and 200 mkm and evaluate the implant-abutment surface. 2. The method of claim 1, characterized in that for providing parallelism between the implant-abutment surface, the upper part of a radiographic stent film holder is cut.
Patent EA-007667-B1 (EA)
Title: Method for joining itm materials using partially or fully transient liquid phase
Inventor: BUTT DARRYL P
IPC: B32B7/00
Filed: 2004-03-19
Abstract: A method of forming a composite structure comprises: (1) providing a first and a second sintered bodies comprising a first and a second multicomponent metallic oxides having similar a first and a second crystal structures, which are a perovskite and a fluorite; (2) providing a joint material comprising at least one metal oxide, which (a) comprises (i) at least one metal of an identical Group of the IUPAC periodic table as at least one sintered body metal in one of the first multicomponent metallic oxide, (ii) a first row D-Block transition metal not contained in the first multicomponent metallic oxides and/or (iii) a lanthanide not contained in the first multicomponent metallic oxides; (b) is free of metals contained in the first multicomponent metallic oxides; (c) is free of cations of boron, silicon, germanium, tin, lead, arsenic, antimony, phosphorous, and tellurium; and (d) has a melting point below the sintering temperatures of said sintered bodies; and (3) heating the sintered bodies and the joint material to a joining temperature above the melting point and below the sintering temperatures.
Patent EA-006728-B1 (EA)
Title: Low-bench rock-cutting machine
Inventor: GARMS ANDREY YAKOVLEVICH
IPC: E21C47/10
Filed: 2005-01-11
Abstract: The invention relates to mining industry and can be used for cutting masonry units, namely wall building blocks in open quarries.The inventive result is directed at simplifying design of low-bench rock-cutting machine, increasing its reliability and decreasing its dimensions.The low-bench rock-cutting machine comprises a chassis 1, with open rollers 2, a mechanism 3 for moving the chassis (fig. 2), vertical saws 4 with drives designed as a hingedly-mounted relative to the chassis 1 reduction gear 5 with a conic gearing 6 (fig. 3) the vertical saws are mounted on an output shaft of the reduction gear which is connected to a hydro cylinder 8, the other end of which is arranged on the chassis 1.The low-bench rock-cutting machine comprises horizontal saws 9 with a drive 10 and a means for horizontal and vertical displacement of the horizontal saws 9 made as a lever 11 and a screw pair (fig. 4). The lever 11 is mounted on the chassis 1 rotatably relative to a vertical axis 12 (fig.4) and is coupled with the hydro cylinder 13 for the horizontal displacement of the horizontal saws 9. A vertical bushing 14 is mounted on the lever end, a drive 10 for rotating the horizontal saws 9 and adapted to a vertical displacement is arranged in the bushing. A bracket 14 is mounted on the vertical bushing 14 with a threaded hole 16 made on the bracket end.The screw pair comprises a screw 17 mounted on the drive 1o for rotating the horizontal saws 9 and the bracket 15 with the threaded hole 16. During starting to avoid turning the drive 10 a stopper 18 is used mounted on the drive 10 and interacting with the hole 19 made in the bracket 15 of the vertical bushing 14.The low-bench rock-cutting machine comprises a control board 20 and a hydraulic station 21 mounted on the chassis 1 and connected to hydro cylinders 8 and 13. The vertical 4 and horizontal 9 saws are provided with a protective housing 22 and 23 correspondingly. Rails 24 and a gauge (not shown on the drawing) are used for cross-cutting by the low-bench rock-cutting machine.
Patent EA-011823-B1 (EA)
Title: Bacterial selection system and use thereof
Inventor: TENSON TANEL
IPC: C12N15/70
Filed: 2004-09-15
Abstract: A selection system comprising a bacterial cell deficient of an araD gene encoding L-ribulose-5-phosphate 4-epimerase gene (EC 5.1. 3.4.), in which a vector is inserted as a selection marker carrying the araD gene encoding active L-ribulose-5-phosphate 4-epimerase gene. A method of selecting the bacterial cells transformed with the vector carrying the araD gene encoding active L-ribulose-5-phosphate 4-epimerase gene as the selection marker and gene of interest, wherein said method comprising inserting the vector into the host cell deficient of an araD gene encoding L-ribulose-5-phosphate 4-epimerase gene and growing the cells in a growth medium containing arabinose. The non-antibiotic selection marker makes the system suitable for producing therapeutics. The araD gene is not essential for growth of the host but manipulation of it affects the growth under certain selective conditions. Deletion of araD leads to accumulation of substance which is toxic to the host but not to humans. The araD gene is relatively small and therefore a small vector may be constructed, which requires less energy for replication, and leads to increased growth rate and yield.
Patent EA-011991-B1 (EA)
Title: Ostenidine-containing lozenges used against inflammatory oral and pharyngeal diseases
Inventor: MIETHING HOLGER
IPC: A61P31/04
Filed: 2005-08-19
Abstract: The invention relates to a lozenge, especially based on caramel, which is suitable for the topical treatment of inflammatory oral and pharyngeal diseases. Said lozenge contains octenidine, preferably in the form of octenidine dihydrochloride, as an active substance such that a therapeutically effective amount of octenidine, preferably octenidine dihydrochloride, is released during sucking when the lozenge is administered and sucked in a patient's oral and pharyngeal cavity.
Patent EA-017620-B1 (EA)
Title: Potash-magnesium fertilizer
Inventor: ILIIN VIKTOR PAVLOVICH
IPC: C05D1/04
Filed: 2009-08-28
Abstract: The invention relates to producing and application of mineral fertilizers, in particular to potash-magnesium fertilizers (solid and liquid) produced from natural raw materials and comprising potassium, magnesium and natural microelements. In a result of carnallite extraction by underground dissolution through a borehole the fertilizer comprises recirculated brine of the following composition, mass%: MgCl– 10.2-21.2; KCl – 8.5-3.5; NaCl – 5.8-2.1; setting salt separating on the surface from recirculated brine, mass%: KCl – 63.49-97.20; MgCl– 14.49-0.26; NaCl – 6.23-0.25; CaCl– 0.03-0.11; CaSO– 0.11-0.05; crystallization HO – 16.45-0.53; hydroscopic HO – 26.9-0.11; insoluble residue – 0.06-1.60, and also slurry mixed salt precipitating in the underground cell of dissolution and recovered to the surface by hydromining devices with content of NaCl - 40-50; KCl - 50-40; MgCl– 4.0-0.5, the insoluble residue - 10-20; hydroscopic HO up to 35.0.
Patent EA-016859-B1 (EA)
Title: Flexible wet-sheet package
Inventor: KAKURA YOSHIKAZU
IPC: A47K7/00
Filed: 2008-10-31
Abstract: The invention relates to a flexible wet-sheet package (1) which comprises wet sheets (2) impregnated with a liquid, a flexible film bag (3) in which the wet sheets (2) are packaged and which has a sheet takeout opening (31), and a label (5) with which the sheet takeout opening (31) is covered and which is separably adherent to a surface of the film bag (3). Upon peeling the label (5) off the film bag (3), the sheet takeout opening (31) becomes open and a pressure-sensitive adhesive layer (53) is exposed in an area which is in the surface of the film bag (3) and surrounds the sheet takeout opening (31). A substrate (54) is interposed between the pressure-sensitive adhesive layer (53) and the surface of the film bag (3). The substrate (54) is made of a film having higher compression strength than the film constituting the film bag (3).
Patent EA-021305-B1 (EA)
Title: Method of eye treatment for prevention of presbyopia and glaucoma, and means for carrying out said treatment
Inventor: FILIPPELLO MASSIMO
IPC: A61N1/36
Filed: 2009-06-11
Abstract: A method of eye treatment for prevention of presbyopia and glaucoma envisages stimulation of the ciliary body to determine contraction thereof via a low-voltage d.c. current sent in the form of pulse trains. This contraction, if applied in a rhythmic way at a constant frequency, subjects the ciliary muscle to a passive gymnastics increasing the force of contraction thereof, the dimensions, and the efficiency. This increase of force enables the crystalline to be moved with greater efficiency and consequently increases the power of accommodation thereof. Likewise, the contraction of the ciliary muscle stretches the tendinous formation in direct contact with the sclero-corneal trabeculate and increases the distance between the lamellae of the sclero-corneal angle, restoring the natural function of the trabeculate and thus preventing glaucoma. Stimulation of the anatomical area corresponding to the ciliary body occurs through the use of conductive electrodes positioned in direct contact with the bulbar conjunctiva at an appropriate distance from the corneal limbus. A contact lens is described containing four electrodes, which facilitates contact of the electrodes in both eyes and facilitates the work of the operator.
Patent EA-022803-B1 (EA)
Title: Polymeric conjugates of paclitaxel and docetaxel with ph-controlled releasing of the cancerostatic agent
Inventor: ETRYCH TOMAS
IPC: A61P35/00
Filed: 2010-02-09
Abstract: The present invention describes a polymeric conjugate consisting of a derivative of a cytostatic agent selected from the group of taxanes, in particular paclitaxel (PTX), docetaxel (DTX) or larotaxel (LTX), and a polymeric carrier prepared on the basis of a linear or biodegradable grafted copolymer consisting of units of the basic copolymer N-(2-hydroxypropyl)methacroylamide (HPMA) and units containing methacryloylated hydrazones of amino acids or oligopeptides. The invention also deals with a method of preparation of the above mentioned polymeric conjugate, in which the polymeric carrier is subjected to polymer-analogous transformation of the carrier by reaction with an ester of the oxo acid and the cytostatic agent. The polymeric conjugate is used for the preparation of a medicament for treatment of tumour diseases.
Patent EA-028219-B1 (EA)
Title: Sustainable method and system for treating water bodies affected by bacteria and microalgae at low cost
Inventor: FISCHMANN T FERNANDO
IPC: C02F1/68
Filed: 2011-09-12
Abstract: A system for treating and maintaining bodies of water for low density recreational use is disclosed. A system of the invention generally includes containing means, coordination means, chemical application means, non-intrusive mobile suction means, and filtration means. The coordinating means can receive information regarding controlled water quality parameters, and can timely activate the processes necessary to adjust the water quality parameters within their respective limits. The disclosed system filters only a small fraction of the total water volume, up to 200 times less per day than the flow filtered by conventional swimming pool filtration systems. The disclosed methods and system also use less chemicals than conventional swimming pool water treatment systems. The system of the present invention can be used to treat recreational water bodies and provide sustainable methods for producing water that meets Environmental Protection Agency (EPA) requirements for recreational water, for bathing with full body contact.
Patent EA-028880-B1 (EA)
Title: Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
Inventor: BERKHOUT MICHAEL PETRUS JOZEF
IPC: C12P19/14
Filed: 2013-11-07
Abstract: The invention relates to a process for the preparation of a sugar product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; and d) optionally recovery of a sugar product; wherein during part of the time of the enzymatic hydrolysis, oxygen is added to the ligno-cellulosic material and during part of the time of the enzymatic hydrolysis less oxygen is added to the ligno-cellulosic material compared to the other part of the time of the enzymatic hydrolysis, preferably no oxygen is added to the ligno-cellulosic material.
Patent EA-025960-B1 (EA)
Title: Stabilization of tiotropium solvates
Inventor: CERNA IGOR
IPC: A61P11/06
Filed: 2012-11-05
Abstract: A method for stabilization of micronized or milled solvates of tiotropium bromide, in which the solvates are deposited in a saturated atmosphere of the adequate solvent for the time period sufficient for recovery of the original amount of solvent in the solvate. A stable tiotropium bromide solvate with 1,3-propanediol.
Patent EA-031746-B1 (EA)
Title: STIMULATORS OF sGC
Inventor: NAKAI TAKASHI
IPC: C07D495/04
Filed: 2014-03-14
Abstract: The present invention relates to a compound of Formulaor a pharmaceutically acceptable salt thereof. A pharmaceutical composition as a stimulator of soluble guanylate cyclase (sGC), comprising the above mentioned compound or a pharmaceutically acceptable salt thereof and one or more inert excipients is also the object of the present invention.
Patent EA-028077-B1 (EA)
Title: N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use
Inventor: PATEL LISA
IPC: C07D213/61
Filed: 2014-06-24
Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (COPD); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; Sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or Paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as Behcet's disease. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.
Patent EA-030916-B1 (EA)
Title: Method for producing inverted honey concentrate
Inventor: MKRTCHYAN OVIK LEONARDOVICH
IPC: C12P19/24
Filed: 2014-11-04
Abstract: The invention relates to biotechnology and medicine, and specifically to methods for enzymatic hydrolysis of natural honey, and can be used in agriculture, food industry, pharmaceutics and cosmetics. The technical result of the proposed method is production of a safe and cheaper product and widening of its application area. The method comprises dissolution of honey in purified water in a ratio of 4.8:5.0, respectively, elevation of temperature to 45°C, and conduction of hydrolysis by honey own enzymes. pH of the solution is brought to 6.0, and every 10 min during 50-60 min the pH value is corrected until a stabilized pH value within 4.5-5.0 is achieved. The honey concentrate is cooled to room temperature, stirred, 96% ethyl alcohol in an amount of 2% of the total volume of the honey concentrate produced is added as a stabilizer, the concentrate is stirred and allowed to settle during 60 min.
Patent EA-030328-B1 (EA)
Title: Soap bar formulations with improved skin softness comprising nonionic polymer structuring system
Inventor: BORTOLAI GISLENE SPLENDORE
IPC: C11D9/48
Filed: 2014-11-19
Abstract: The present invention relates to bars which provide specific combinations and amounts of nonionic polymer, polyol, short chain fatty acid and solid particles. These specific combinations provide both improved sensory and improved fragrance delivery.
Patent EA-034605-B1 (EA)
Title: Novel rig-i ligands and methods for producing them
Inventor: GOLDECK MARION
IPC: C07H21/02
Filed: 2013-09-26
Abstract: The present invention provides new triphosphate-modified oligonucleotides which may be used as RIG-I ligands, as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
Patent EA-038560-B1 (EA)
Title: Method for the diagnostics of the left ventricle diastolic dysfunction type iii in a patient with sinus rhythm without primary mitral regurgitation and mitral stenosis
Inventor: ZHERKO OLGA MIKHAILOVNA
IPC: G01N33/49
Filed: 2019-03-06
Abstract: The invention relates to medicine and can be used in ultrasonic investigation for the diagnostics of the left ventricle diastolic dysfunction type III (restrictive, severe type) in a patient with a sinus rhythm without primary mitral regurgitation and mitral stenosis. The objective of this invention consists in providing a possibility of diagnostics of the left ventricle diastolic dysfunction type III in patients with sinus rhythm. The said objective is attained by the method for the diagnostics of the left ventricle diastolic dysfunction type III in a patient with sinus rhythm without primary mitral regurgitation and mitral stenosis, comprising the determination of the level of NT-proBNP in blood serum; determination of the ratio of E and A (E/A) peak speeds of the transmitral flow, time of E peak deceleration in the transmitral flow (DTE), left ventricular ejection fraction (LV EF) in the pulsed wave doppler mode, and in case the NT-proBNP value exceeding 408 pg/ml, E/A value exceeding 1.86, DTE value equal to 146 ms or less, LV EF value equal to 49.51% or less, the left ventricle diastolic dysfunction type III is diagnosed.
Patent ES-2166328-B1 (ES)
Title: Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos
Inventor: MARTINEZ GIL ANA
IPC: A61K31/4015
Filed: 2000-05-11
Granted: 2003-09-16
Abstract: Inhibidores heterocíclicos del enzima GSK 3 útiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos La invención describe la inhibición del enzima glucógeno sintasa quinasa 3 (GSK 3) por una serie de 1,2,4-tiadiazolidin-3,5-dionas con posible aplicación dentro del ámbito de la industria farmacéutica, fundamentalmente como fármacos para detener o paliar procesos neurodegenerativos como la enfermedad de Alzheimer, la diabetes mellitus no insulina dependiente y procesos hiperproliferativos como el cáncer.
Patent ES-2220157-B1 (ES)
Title: Grupo de plantas, metodo para plantar arboles y metodo para cultivar plantas.
Inventor: NIWA KOZO
IPC: A01H7/00
Filed: 2003-03-14
Granted: 2006-01-16
Abstract: Grupo de plantas, método para plantar árboles y método para cultivar plantas. Inhibición de los daños a los bosques causados por rayos ultravioleta. Esto se realiza mediante la selección por cochicina de tipo triploides o tetraploides de cromosomas y mediante la repoblación para formar un grupo de plantas resistente a los rayos ultravioleta creando un bosque artificial.