Patent SG-11201408791T-A (SG)
Title: Dihydropyrimidine compounds and their application in pharmaceuticals
Inventor: ZHANG YINGJUN
IPC: C07D403/14
Filed: 2013-08-23
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 February 2014 (27.02.2014) WIPOIPCT (10) International Publication Number WO 2014/029193 A1 (51) International Patent Classification: C07D 401/00 (2006.01) C07D 401/14 (2006.01) C07D 401/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 409/14 (2006.01) C07D 407/14 (2006.01) C07D 405/14 (2006.01) C07D 403/14 (2006.01) A61K31/506 (2006.01) A61K31/505 (2006.01) A61P 31/12 (2006.01) (21) International Application Number: PCT/CN2013/001001 23 August 2013 (23.08.2013) (22) International Filing Date: (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201210303033.4 24 August 2012 (24.08.2012) CN 201310116949.3 3 April 2013 (03.04.2013) CN (71) Applicant: SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; LIN, Taoxi, Northern Industrial Area, Songshan Lake, Dongguan, Guangdong (CN). (72) Inventors: ZHANG, Yingjun; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, Dongguan, Guangdong 523871 (CN). REN, Qingyun; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, Dongguan, Guangdong 523871 (CN). LIU, Xinchang; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, Dongguan, Guangdong 523871 (CN). SIEGFRIED, Gold- mann; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, Dongguan, Guang­ dong 523871 (CN). (74) Agent: CN-KNOWHOW INTELLECTUAL PROP­ ERTY AGENT LIMITED; 18th Floor, Tower B, CEC Plaza, No.3 Dan Ling Street, Haidian District, Beijing 100080 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS o\ i-H o\ CJ o o CJ o & N R 4 (I) O R 1 '\"Yi* (la) (57) Abstract: Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically,provided herein are compounds having Formula (I) or (la), or an enantiomer, a diastereoisomer, tautomer, hydrate, solvate, a a a or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (la), or an enantiomer, a diastereoisomer, tautomer, a a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV dis -