baber/WOPTO huggingface dataset:
Patent IL-75639-A0 (IL)
Title: Preparation of n-phenyl(pyridyl)-sulfonyldiamides
IPC: C07C301/00
Filed: 1985-06-26
Abstract: A process for the preparation of N-phenyl(pyridyl)sulfonyldiamides by reacting a 2-aminobenzoic acid (nicotinic acid) derivative with sulfur trioxide, chlorosulfonic acid or an adduct of sulfur trioxide with a tertiary amine in the presence of a diluent and of a tertiary amine, and reacting the resulting sulfamate with a primary amine and a phosphorus halide, or by reacting a 2-aminobenzoic acid (nicotinic acid) derivatives with an N-alkyl(cycloalkyl)sulfamic acid or a salt of this acid in the presence of a diluent and of a phosphorus halide.
Patent IL-78175-A0 (IL)
Title: Azolylmethyloxiranes,their preparation and their use as crop protection agents
IPC: A01N43/653
Filed: 1986-03-17
Abstract: There are described compounds of the formula 
<IMAGE>
 where R, Hal and Z are as defined in the description, and their preparation. The compounds are suitable as fungicides.
Patent IL-79710-A0 (IL)
Title: Substituted benzoate esters of estrogens,their preparation and pharmaceutical compositions containing them
IPC: C07J41/00
Filed: 1986-08-13
Abstract: Substituted benzoate ester prodrugs of β-estradiol and ethynyl estradiol are provided which have improved bioavailability and extended duration of action when administered orally.
Patent IL-92180-A0 (IL)
Title: Method of preventing or reducing eosinophilia
IPC: C07K16/24
Filed: 1989-11-01
Abstract: A method of preventing or reducing eosinophilia associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-5. Preferably, the antagonist is a blocking monoclonal antibody specific for human interleukin-5, or a fragment or binding composition derived therefrom.
Patent IL-93325-A0 (IL)
Title: Isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them
IPC: A61K31/4725
Filed: 1990-02-08
Abstract: The present invention provides intermediates for novel bicyclic derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.
Patent IL-93609-A0 (IL)
Title: Yeast processing system
IPC: C12N15/62
Filed: 1990-03-02
Abstract: A polypeptide for production in yeast comprises a fusion of a signal peptide, a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amino acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein, or both. The heterologous protein may, for instance, be aprotinin or insulin precursor or an analogue thereof.
Patent SE-8701402-A0 (SE)
Title: Anordning vid luftbehandlingsanläggningar
Inventor: TORSTEN SCHÖNFELDT
IPC: F24F13/28
Filed: 1987-04-03
Abstract: i 6 , SAMMANFATTNING. I luftbehandlingsanlaggningar dr det onskvart att fOrbattra: verkningsgraden och Itinsamheten for atervinningsanlaggningar genom battre temperaturutnyttjande och rationellare installation. luftkvalite n genom bortfiltrering av icke bundna foreningar varvid aven risken for belaggning i varmeackumuleringsenheterna minskar komforten i rummens vistelsezoner genom lagre lufthastighet och battre stromningsbilder oavsett karaktamii av nyttjande MOjligheterna till energisparande aven i den provisoriska uppvarmningen och uttorkningen exernpelvis under byggskedet. Detta har i fOreliggande ansOkan lOsts genom att: utnyttja varmelackaget till ouppvarmda byggnadsdelar (delpatent 1 och 3, ritning 1 o.2, "Luftvagsregulator") Minimera antalet tak- och vagg-genomfOringar (delpatent 2, ritning 2, "1nstallationsstosen") filtrera ventilationsluften saval vid friskluftsintaget som vid franluf tsdon intill fororeningskallan. (delpatent 4, variant A - D, ritning 3 - utnyttja "Sackfilterdonet" som kombinerat filter- och luftdon och darigenom nd lagre lufthastighet och battre strOmningsbild. (delpatent 4, variant E, ritning 7) tillfora den kilmatbehandlade luf ten rumsomslutande i en "spaltsockel" som samtidigt utgor luf tvag, tilluftsdon och golvsockel. (delpatent 5, ritning 8 - 10)
Patent FI-20010996-A0 (FI)
Inventor: MAELKKI YRJOE
IPC: A23C19/05
Filed: 2001-05-11
Abstract: The invention relates to a method for preparing low-fat, hard or semi-hard cheese in a way to prevent occurrence of a rubbery texture. According to the method, starch is included in the cheese by adding small-sized starch granules in the milk to be curdled in a way, that the granules remain in the curdle and in the cheese grains obtained from it, which then are pressed to cheese. Starch granules can be added as such, or being preswelled in a way to avoid gelatinization, or amylose on the surface of the granules and transferred into the solution is complexed using a monoglyceride or other polar lipids. Starch can also be impregnated with flavour or aroma compounds or enzymes, or precoated or partly precoated with a lipid to improve the taste and mouthfeel of the cheese.
Patent FI-20021719-A0 (FI)
Inventor: NISSINEN VILHO
IPC: B05B1/04
Filed: 2002-09-26
Abstract: The invention relates to a nozzle and method for use in the coating of a web-like material by means of high-pressure spraying techniques and to a method for coating web-like material using such a nozzle. The nozzle comprises a preliminary nozzle (2) and a secondary nozzle (1), the area of the flow orifice of the preliminary nozzle (2) being at the most 1.1 times the transverse area of the flow orifice of the secondary nozzle (1).
Patent IL-103603-A0 (IL)
Title: Biosynthetic process for the preparation of chemical compounds
IPC: C07K1/113
Filed: 1992-10-30
Abstract: Novel recombinant DNA molecule (I) has a sequence corresp. to one or more DNA sequences contd. in a Bgl II fragment of the 54 Rpb episomal element pTii32 from staphylococcus epidermis and codes for at least one protein having EpiB, EpiC, EpiD, EpiP or EpiQ enzymatic activity; or (I) is capable of hybridising to the BglII fragment and codes for at least one protein with the above enzymatic activities. Also claimed are: the protein EpiB, EpiC, EpiD, EpiP or EpiQ in the absence of impurities with which it is normally associated; a fusion protein compising one of EpiB, C, D, P or Q and an auxiliary protein, a fusion protein in which one of the Epi B, C, D, P or Q is fused to an auxiliary protein such that the junction between the Epi protein and the auxiliary protein can be cleaved by an enzyme; and a method of producing a protein with at least one of the structural features of a lantibiotic. In the novel method comprising inserting a DNA sequence coding for a predetermined aminoacid sequence in a vector plasmid such that it is under the control of a regulator promoter, transforming the resulting plasmid vector into a host and cultivating the host so as to express the DNA and isolating the protein, the improvement comprises also transforming the host by a DNA sequence or sequences comprising functionally operable genes coding for EpiB, C, D, P or Q (or an active variant), the genes being expressed during cultivation of the host so that the resulting protein has at least one of the structural features of a lantibiotic.
Patent IL-106846-A0 (IL)
Title: Roll formed metal member with reinforcement indentations
IPC: E04C3/09
Filed: 1993-08-31
Abstract: PCT No. PCT/CA92/00514 Sec. 371 Date Mar. 1, 1995 Sec. 102(e) Date Mar. 1, 1995 PCT Filed Nov. 25, 1992 PCT Pub. No. WO94/05872 PCT Pub. Date Mar. 17, 1994.A metal member having at least one edge formation, and a web extending from the edge formation, a plurality of generally triangular openings formed in the web at spaced intervals, the triangular formations being alternately reversed relative to one another, a plurality of generally diagonal struts extending between adjacent triangular openings, edge portions along either edge of the web portion, with the struts extending from one said edge portion to the other and merging integrally therewith, flange formations formed from the web around the generally triangular openings, and lying at an angle thereto, whereby to form the diagonal struts with a generally channel shaped cross section, and forming intermittent flanges along the web edges at the base of each triangular opening, the triangular openings defining generally curved corners, and, generally three-sided indentations formed in the web edge at the roots of each of the diagonal struts.
Patent IL-115185-A0 (IL)
Title: Pyrimido (5,4-d) pyrimidines pharmaceutical compositions containing them their use and processes for their preparation
IPC: A61P29/00
Filed: 1995-09-06
Abstract: The present invention relates to pyrimido[5,4-d]pyrimidines of the general formula    <IMAGE>  (I)  in which Ra to Rc are as defined herein, their tautomers, their stereoisomers and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibiting action on signal transduction mediated by tyrosine kinases, their use for the treatment of diseases, in particular tumor diseases.
Patent IL-141550-A0 (IL)
Title: Methods and compositions for the prevention or treatment of cancer
IPC: A61K47/48
Filed: 1999-09-03
Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
Patent IL-143141-A0 (IL)
Title: Thermostable enzyme promoting the fidelity of thermostable dna polymerases-for improvement of nucleic acid synthesis and amplification in vitro
IPC: C12Q1/686
Filed: 2000-09-27
Abstract: A purified thermostable enzyme is derived form the thermophilic archaebacterium Archaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3'-5'exonuclease and cleaves to produce 5'-mononucleotides. Thermostable exonucleases are useful in many recombinant DNA techniques, in combination with a thermostable DNA polymerase like Taq especially for nucleic acid amplification by the polymerase chain reaction (PCR). <IMAGE>
Patent IL-152690-A0 (IL)
Title: Communication apparatus
IPC: H04L12/28
Filed: 2001-05-11
Abstract: A communication unit comprised a first and second splitting/combining device, each having terminals for receiving and transmitting a CATV signal and a data signal, respectively, means for combining the CATV signal and the data signal and a third terminal for receiving and transmitting the combined signal. The first terminals of the splitting/combining devices are interconnected through a device for extracting said CATV signals and each of the second terminals is connected to a switch controlled in such a way that the second terminals are either connected to each other directly or connected to a connection device for connection to a computer. The data signal can bypass flats desiring no data connection. Also, the communication unit may be implemented in two parts: one wall mounted part and one adapter connectable to the wall mounted part and comprising the connection unit, which is needed only where a data connection is wanted.
Patent IL-156845-A0 (IL)
Title: Graft rejection suppressors
IPC: A61P37/06
Filed: 2002-02-05
Abstract: It was found that antibodies against AILIM (also known as ICOS and 8F4) and AILIM-Ig have significant therapeutic effects towards the suppression and prevention of graft rejection. Graft rejection is a serious problem associated with tissue or organ transplantation (allotransplantation or xenotransplantation), performed to treat various organ failures (liver, heart, lung, kidney, pancreas, etc.) .
Patent IL-159140-A0 (IL)
Title: Precisely aligned lens structure and a method for its fabrication
IPC: G02B3/00
Filed: 2002-12-13
Abstract: A lens structure includes a nonplastic first lens having a first-lens central optical region lying in the light path, and a first-lens rim between the first-lens central optical region and a first-lens periphery of the first lens. The first-lens rim includes a first-lens mating surface. A nonplastic second lens has a second-lens central optical region lying in the light path, and a second-lens rim between the second-lens central optical region and a second-lens periphery of the second lens. The second-lens rim includes a second-lens first mating surface conformable to the first-lens mating surface and in a facing and contacting relation to the first-lens mating surface. The first lens and the second lens are aligned to within a first-lens/second-lens tolerance of not greater than about 0.00005 inch. The first-lens first mating structure and the second-lens first mating surface may be diamond-point machined to the high tolerances, and then assembled.
Patent IL-163976-A0 (IL)
Title: Pharmaceutical combination for the treatment of benign prosttic hyperplasia or for the long-term prevention of acute urinary retention
IPC: A61K31/56
Filed: 2003-04-17
Abstract: The present invention relates to a new pharmaceutical combination for treating benign prostatic hyperplasia (BPH) or for the long-term prevention of acute urinary retention (AUR).
Patent IL-169364-A0 (IL)
Title: Non-pegylated long-circulating liposomes
IPC: A61K9/127
Filed: 2005-06-23
Abstract: Long circulating non-pegylated liposomes are formed by hydrating lipids formed from a lipid solution comprising a phospholipid, sterol and a solvent with 10 to 35 ml aqueous hydration medium per mmole of phospholipid. The hydration can be carried out before or after solvent removal. Preferably, the hydration medium comprises ammonium sulphate and sucrose and extraliposomal ammonium sulphate is removed using a sucrose-histidine buffer solution. The liposomes can be loaded with a therapeutic or diagnostic agent, especially doxorubicin hydrochloride.
Patent IL-205428-A0 (IL)
Title: An insonification device that includes a three - dimensional network of emitters arranged in at least two concentric spirals, which are designed to generate a beam of high - intensity focussed waves
Filed: 2010-04-29
Abstract: The invention concerns a device (1) for the insonification of an environment or medium, which is designed to generate a beam of focussed waves around a point in a so-called focus zone (20), used for imaging the medium or changing the properties of the medium, with the insonification device (1) having an intrinsic or extrinsic support structure on which is installed a network of a predetermined number of ultrasound transducers (12) that are designed to be controlled independently for generation of the focussed wave beam. According to the invention, the transducers (12) used for the generation of the focussed wave beam are located in a homogeneous spatial distribution along at least two concentric spirals (11) that are wound onto a three-dimensional concave area (10) whose shape and size are chosen to allow optimal focusing of the beam at a predetermined focal length, and whose concave side is oriented toward the focus zone (20).
Patent RO-128862-A0 (RO)
Title: Process for registering and recognizing an image reproduced by oscillations in frequency or period range
Inventor: DONTU Zaharia
IPC: G01D1/16
Filed: 2013-01-29
Abstract: The invention relates to a process for registering and recognizing the image reproduced by mechanical oscillations in frequency and period range. According to the invention, the process consists in selecting three points (B, C and D), characteristic to the oscillations in frequency or period range, connecting the points to one another, projecting them on the axis of ordinates of the coordinate system to which they are connected, the obtained triangle (6) being intersected by the projection lines on the same axis of points (A, B, and C') which reproduce the amplitude in frequency or period range of the characteristics relating to the studied process, and form the actual picture for each object which is registered and stored and then extracted by the variation of the relative positions of the three points (B, C and D), but also by the variation of the distances between them on the axis of ordinates, there being obtained several significations by means of which there can be created symbol variants for a computer memory.
Patent CU-21903-A1 (CU)
Title: Accionamiento de maquinita de lizos para telar
Inventor: MAKACHEV ALEKXANDR NIKOLAEVICH
IPC: D03C1/00
Filed: 1985-12-05
Abstract: El accionamiento de maquinita de lizos para telar posee un mecanismo de levas, levas 6 y contralevas 7 que están colocadas fijas e interaccionan con los rodillos 8 ajustados al satélite 2 del mecanismo diferencial cuyo disco de mando 4 está unido al eje principal de la máquina herramienta.
Patent MA-18463-A1 (MA)
Inventor: PETRUS FRANCISCUS ALPHONSUS MA
IPC: C01B25/28
Filed: 1979-05-31
Abstract: Process and device for the preparation of a product containing ammonium orthophosphate, and product obtained by this process. Phosphoric acid and gaseous ammonia are put together by means of a two-phase spraying device A provided with two coaxial ducts 1 and 2 through the outer one 1 of which the ammonia and through the inner one 2 of which the phosphoric acid is passed. The axial outflow rate of the phosphoric acid from the spraying device is from 1-10 m/sec. the axial outflow rate of the ammonia therefrom is from 200-1000 m/sec. (N.T.P.) and the two flows are discharged within a cylindrical reaction zone B which is coaxial with the spraying device and has a diameter D of 2-4 times the diameter of the outer ammonia discharge durt of the spraying device and a length of 10-25 times said diameter D. The reaction zone debouches in a collecting space. A homogeneous product substantially free of ammonium polyphosphate is obtained.
Patent MA-27946-A1 (MA)
Title: Omega-carboxyaryldiphenyluree fluoro-substituee pour le traitement et la prevention de maladies et d'etats pathologiques.
Inventor: DUMAS JACQUES
IPC: A61K31/675
Filed: 2006-02-13
Abstract: Extrait Un composé de Formule (I) ou un sel, ou une prodrogue ou un métabolite, des compositions contenant de tels composés et l'utilisation de ces composés pour traiter des maladies assistées par raf, VEGFR, PDGFR, p. 38 et flt-3.
Patent MA-28041-A1 (MA)
Title: Molecules de liaison therapeutiques
Inventor: KOLBINGER FRANK
IPC: C12N15/13
Filed: 2006-03-14
Abstract: L'invention concerne une molécule comprenant au moins un site de liaison antigène, comprenant en séquences des régions hypervariables CDR1, CDR2 et CDR3, ladite CDR1 présentant une séquence d'aminoacides Asn-Tyr-Ile-IIe-His (NYIIH), ladite CDR2 présentant une séquence d'aminoacide Tyr-Phe-Asn-Pro-Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe -Lys-GIy (YFNPYNHGTKYNEKFKG) et ladite CDR3 présentant une séquence d'aminoacide Ser-Gly-Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT) ; par exemple comprenant, de plus, en séquences les régions hypervariables CDR1', CDR2' et CDR3', CDR1' présentant la séquence d'aminoacide Arg-Ala-Ser-Gln-Asn-Ile-Gly-Thr-Ser-IIe-Gln (RASQNIGTSIQ) ; CDR2' présentant la séquence d'aminoacide Ser-Ser-Ser-Glu-Ser-Ile-Ser (SSSESIS) et CDR31 présentant la séquence d'aminoacide Gln-GIn-Ser-Asn-Thr-Trp- Pro-Phe-Thr (QQSNTWPFT), par exemple un anticorps chimère ou humanisé, utilisé en tant que produit pharmaceutique.
Patent MA-28176-A1 (MA)
Inventor: BUCHDUNGER ELISABETH
IPC: A61K31/506
Filed: 2006-05-24
Abstract: The present invention relates to the treatment of KIT dependent diseases that are characterized by a mutant form of KIT whereby the mutant KIT is identified and an appropriate inhibitor of the mutant KIT is administered.
Patent UY-23740-A1 (UY)
Title: Dispositivo intrauterino bovino
IPC: A01K29/00
Filed: 1994-03-10
Abstract: La presente invención se refiere a un dispositivo capaz de ser implantado en el interior del útero bovino con el objeto de aumentar el ritmo de engorde y facilitar el manejo de vacas y vaquillonas hembras, caracterizado porque comprende un cuerpo constituido por un material sintético en forma de V invertida, sobre el cual se halla enrollado un filamento de cobre y además posee una cola constituido por nylon. Dicho material sintético comprende un nylon.
Patent UY-25237-A1 (UY)
Title: Lapicera esferografica
Inventor: RICHARD DIETER BUSCHLE
IPC: B43K7/00
Filed: 1998-11-06
Abstract: LA PRESENTE INVENCION SE REFIERE A UNA LAPICERA ESFEROGRAFICA QUE POSEE UN CUERPO TUBULAR, UN TUBO DE CARGA CONTENIENDO UNA CARGA DE TINTA, UNA PUNTERA ESFEROGRAFICA Y UN ELEMENTO DE CONEXIÓN PROPORCIONANDO COMUNICACIÓN ENTRE EL INTERIOR DEL TUBO DE CARGA Y LA PUNTERA ACOPLADO AL CUERPO TUBULAR EN RELACION DE ENCAJE, EN QUE EL ELEMENTO DE CONEXIÓN POSEE UNA EXTREMIDAD FORMADA CON UNA PORCION DE ENCAJE EXTERNA ENCAJADA SOBRE LA EXTREMIDAD DE ESCRITURA DEL CUERPO TUBULAR Y UNA PORCION DE ENCAJE INTERNA ENCAJADA EN EL INTERIOR DE LA EXTREMIDAD DE ESCRITURA DEL TUBO DE CARGA. Esta invención esta destinada a evitar los inconvenientes tales como: quebradura del cuerpo de la lapicera, evitar la pérdida de tinta por tene un elemento de conexión para estancamiento y evitar que se perjudique la determinación visual en el momento que la tinta este próxima a terminarse.
Patent UY-26357-A1 (UY)
Title: Compuestos para el tratamiento de la isquemia
Inventor: MASAMUNE HIROKO
Filed: 2000-09-27
Abstract: Agonistas de A, procedimientos para usar tales agonistas de A3 y composiciones farmacéuticas que contienen tales agonistas de A3. Los agonistas de A3 son útiles para la reducción de lesiones de tejidos producidas por isquemia o hipoxia de los tejidos.
Patent UY-27202-A1 (UY)
Title: Amidas de ácidos carboxílicos antitrombóticas, su preparación y su empleo como medicamentos
Inventor: RIES DR UWE
IPC: C07D239/70
Filed: 2002-03-11
Abstract: La presente invención se refiere a amidas de ácidos carboxílicos de la fórmula (I), en la que R1a R4, Het, Z1, A, Ar y m se definen como en la reivindicación 1. A sus tautómeros, sus estereoisómeros, sus mezclas, sus profármacos y sus sales, que presentan valiosas propiedades. Los compuestos de la fórmula I anterior, en los que R4 representa un grupo ciano, representan valiosos productos intermedios para la preparación de los restantes compuestos de la fórmula general I, y los compuestos de la fórmula general I, en los que R4 representa uno de los grupos amidino mencionados en la reivindicación 1 presentan valiosas propiedades farmacológicas, en particular un efecto antitrombótico y un efecto inhibidor del factor Xa.
Patent UY-28762-A1 (UY)
Title: Nuevos compuestos
Inventor: MARTIN-MALMSTROM JOHANSSON
IPC: C07D401/14
Filed: 2005-02-18
Abstract: Nuevos compuestos, un proceso para su preparación, su uso en terapia y composiciones farmacéuticas que comprenden dichos nuevos compuestos.
Patent UY-28864-A1 (UY)
Title: Derivados de piridoindolona substituidos en -6, su preparación y su aplicación en terapéutica.
Inventor: BERNARD BOURRIE
IPC: A61K31/4412
Filed: 2005-04-21
Abstract: La presente invención tiene por objeto compuestos que responden a la fórmula : en la cual: - R1 representa un átomo de hidrógeno; un grupo alquilo (C1-C4); un grupo -(CH2)mOH; un grupo -(CH2)mCN; un grupo -(CH2)mNR9R10; - R2 representa un átomo de hidrógeno o un grupo alquilo (C1-C4); - R3 representa un fenilo substituido por R6, R7, R8; - R4 representa : R11 . un grupo -C=N-OR12; .un grupo heterocíclico elegido entre: - R5 representa un átomo de hidrógeno o un grupo alquilo (C1-C4). Procedimiento de preparación y aplicación en terapéutica.