baber/WOPTO huggingface dataset:
Patent CA-2509403-A1 (CA)
Title: Pyrazole compounds
Inventor: DRYSDALE MARTIN JAMES
IPC: C07D405/10
Filed: 2003-12-18
Abstract: Compounds of formula (IA) or (IB) or a salt, N-oxide, hydrate or solvate thereof are inhibitors of HSP90, and are of value in the treatment of diseas es responsive to HSP90 inhibition such as cancers. In the formulae, Ar is an aryl, aryl(C1-C6 alkyl), aryl(C1-C6 alkyl), heteroaryl, heteroarylaryl(C1-C6 alkyl), or heteroarylaryl(C1-C6 alkyl) group, any of which being optionally substituted in the aryl or heteroaryl part thereof; R1, is hydrogen or optionally substituted Cl-C6 alkyl; R2 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6 alkenyl, or Cl-C6 alkynyl; or a carboxyl, carboxamide or carboxyl ester group; and ring A is a non aromatic carbocyclic or heterocyclic ring wherein (i) a ring carbon is optionally substituted, and/or (ii) a ring nitrogen is optionally substituted by a grou p of formula -(Alk1)p (Cyc)n-(Alk3)m-(Z)r (Alk2)s Q where Alk1, Alk2 and Alk3 are optionally substituted C1-C3 alkyl, Cyc is an optionally substituted carbocyclic or heterocyclic radical; m, n, p, r and s are independently 0 or 1, Z is -0-, -S-, -(C=O)-, -S02-, -C(=O)O-, -OC(=O)-, -NW-, -C(=O)NRA-, - NRAC(=O)-, -SO2NRA- , or -NRASO2- wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical .
Patent CA-2509894-A1 (CA)
Title: Clip storage for endoscopic clip applier
Inventor: KORTENBACH JUERGEN A
IPC: A61B17/12
Filed: 2005-06-14
Abstract: A flexible endoscopic clip applier includes a flexible coil with a manual actuator coupled to one end and a jaw assembly coupled to the other end. A store of clips is arranged adjacent to the jaw assembly and a clip pusher is arranged adjacent to the store of clips. The actuator includes a lever for opening and closing the jaws, a knob for rotating the jaw assembly, and a crank for dispensing clips.      The knob and the lever are coupled to a single control member which extends through the coil to a joiner where it is joined to a pair of pull wires coupled to the jaws. The crank is coupled to a second control member which is threaded along a distal portion. The threaded portion engages a threaded member near the pusher and is coupled to the pusher such that rotation of the threaded control member by the crank causes the pusher to be moved distally.
Patent CA-2512796-A1 (CA)
Inventor: HANSEN DARRYL P
IPC: B65D81/20
Filed: 1999-03-26
Abstract: A modified atmosphere package includes first and second compartments separated by a partition member that is substantially permeable to oxygen. The first compartment contains an oxygen scavenger activated with an oxygen scavenger accelerator. The second compartment contains a retail cut of raw meat. Various techniques are employed to rapidly reduce the oxygen level in the second compartment below pigment sensitive levels so that the growth of metmyoglobin is inhibited. Some of these techniques increase the flow of oxygen from the second compartment to the first compartment through the partition member, while other techniques directly absorb oxygen within the second compartment.
Patent CA-2517731-A1 (CA)
Title: Photo-catalytic reactor
Inventor: MACPHEE DONALD ELLIOT
IPC: H01M8/10
Filed: 2004-02-27
Abstract: A photocatalytic reactor, capable of generating an electric current by consumption of a fuel containing organic material, comprises a direct oxidation fuel cell including an anode and a cathode, wherein the anode is a photocatalysis-assisted anode which comprises a photocatalyst on a surface of an electrically-conductive substrate so arranged as to be receptive to light, and a light-transmissive proton-conductive membrane arranged between said anode and the cathode, such that light passes through said membrane as a final stage in the optical path to the photocatalyst, the said photocatalyst being capable of promoting the oxidation of organic material and generating electron-hole pairs, said reactor being configured to support multiple cells in a stacked array, is provided with means for introducing said fuel and means for connection to an external electrical circuit.
Patent CA-2519771-A1 (CA)
Title: Implantable nerve signal sensing and stimulation device for treating foot drop and other neurological disorders
Inventor: HOFFER JOAQUIN ANDRES
IPC: A61N1/36
Filed: 2004-04-02
Abstract: A fully implantable nerve stimulation system includes an event-triggered, closed loop control unit (50) that detects physiological events, e.g.  occurrence of heel contact or toe lift event, from nerve signals through one or more nerve cuff electrodes and delivers stimulation pulses to a nerve to produce a desired physiological response, The stimulation system includes a low-noise, low-power nerve signal amplifier (180), accelerometers (156) that detect the orientation angle of a patient~s thigh and a battery powered processor (150) that selectively powers components in the system to detect said physiological events and deliver said stimulation pulses with a minimum of battery power.
Patent CA-2521353-A1 (CA)
Title: Upside-down square-up valve stem seal
Inventor: HEGEMIER TIMOTHY A
IPC: F01L3/08
Filed: 2005-09-27
Abstract: A valve stem seal of an internal combustion engine is described wherein the valve stem seal includes an outer peripheral surface and an inner sealing surface. The inner sealing surface minimizes ingress of a liquid upwardly from an intake port area into an overhead engine area by having at least one sealing lip disposed on an upper portion of the inner sealing surface and extending away from the inner sealing surface.  The sealing lip includes a generally square lower corner.
Patent CA-2525325-A1 (CA)
Inventor: KORT MICHAEL E
IPC: C07D401/04
Filed: 2004-04-29
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.
Patent CA-2526446-A1 (CA)
Title: Biofilm growth prevention
Inventor: KRITZLER STEVEN
IPC: A61L2/18
Filed: 2004-05-18
Abstract: A biostatic coating comprising a coating composition which on drying produces an intrinsically hydrophobic film. The coating composition includes a biocidal complex A-B in which A is a phenolic biocide and B is selected from polyvinylpyrrolidone ("PVP"), PVP polymers, PVP copolymers and mixtures thereof. The coating composition for example is selected from acrylic and methacrylic polymer based compositions, acrylic and methacrylic copolymer based compositions, vinyl polymer based compositions, vinyl copolymer based compositions, epoxy resins, epoxy esters, and mixtures thereof. Suitable biocides for use in the invention include, but are not limited to complexes of PVP or PVP copolymer with triclosan; diclosan; dichlorophen;  orthophenylphenol; orthobenzylparachlorophenol, cresols, xylols, and substituted diphenyl ethers.
Patent CA-2527430-A1 (CA)
Inventor: JOHNS PETER GAMMON
IPC: C23F11/16
Filed: 2004-06-01
Abstract: A firestain and tarnish-resistant ternary alloy of silver, copper and germanium contains from more than 93.5 wt% to 95.5 wt% Ag, from 0.5 to 3 wt%  Ge and the remainder, apart from incidental ingredients (if any), impurities and grain refiner, copper. In order to further protect an article made from the alloy, it may be surface treated with an alkanethiol, alkyl thioglycollate, dialkyl sulphide or dialkyl disulphide.
Patent CA-2528744-A1 (CA)
Title: Composition for treating hair and scalp and method for preparing same
Inventor: STASS DIRK
IPC: A61K8/97
Filed: 2005-12-02
Abstract: An herbal composition for the re-growth of human hair includes the combination of hypercium perforatum, veronica beccabunga, veronica officinalis; and equisetum arvense wherein the combination is infused in water and adapted to be applied to the scalp of a user.
Patent CA-2533648-A1 (CA)
Inventor: GRANT ROBERT BRUCE
IPC: G01N33/00
Filed: 2004-09-23
Abstract: An organic contaminant molecule sensor is described for use in a low oxygen concentration monitored environment. The sensor comprises an electrochemical call comprising a solid state oxygen anion conductor (14) in which oxygen anion conduction occurs at or above a critical temperature Tc, an active measurement electrode (10) formed on a first surface (12) of the conductor for exposure to the monitored environment, the measurement electrode comprising material for catalysing the oxidation of an organic contaminant molecule to carbon dioxide and water, an inert measurement electrode (18), formed on the first surface (12) of the conductor adjacent to and independent from the active measurement electrode, for exposure to the monitored environment, the inert measurement electrode comprising material that is catalytically inert to the oxidation of an organic contaminant molecule, and a reference electrode (20) formed on a second surface (22) of the conductor for exposure to a reference environment, the reference electrode comprising material for catalysing the dissociative adsorption of oxygen. Means (30, 32) are provided for controlling and monitoring the temperature of the cell. Means (34) are also provided for controlling the electrical current la flowing between the reference electrode and the active measurement electrode and the electrical current li flowing between the reference electrode and the inert measurement electrode, thereby to control the flux of oxygen anions flowing between the reference electrode and the active and inert measurement electrodes respectively. The potential difference between the active measurement electrode and the inert electrode is monitored (36), whereby in the absence of organic contaminant molecules the potential difference Vsense between the active and inert measurement electrodes assumes a base value Vb and in the presence of organic contaminant molecules the potential difference Vsense between the active and inert measurement electrodes assumes a measurement value Vm, the value Vm - Vb being indicative of the concentration of organic contaminant molecules present in the monitored environment.
Patent CA-2534336-A1 (CA)
Title: Multiple high-resolution serum proteomic features for ovarian cancer detection
Inventor: HITT BEN A
IPC: G16B40/10
Filed: 2004-07-30
Abstract: A well-controlled serum study set (n = 248) from women being followed and evaluated for the presence of ovarian cancer was used to extend serum proteomic pattern analysis to a higher resolution mass spectrometer instrument platform to explore the existence of multiple distinct highly accurate diagnostic sets of features present in the same mass spectrum. Multiple highly accurate diagnostic proteomic feature sets exist within human sera mass spectra. Using high-resolution mass spectral data, at least 56 different patterns were discovered that achieve greater than 85 % sensitivity and specificity in testing and validation. Four of those feature sets exhibited 100 % sensitivity and specificity in blinded validation. The sensitivity and specificity of diagnostic models generated from high-resolution mass spectral data were superior (P < 0.00001) than those generated from low-resolution mass spectral data using the same input sample.
Patent CA-2535502-A1 (CA)
Inventor: MOLL BRADLEY JON
IPC: A61M37/00
Filed: 2004-07-14
Abstract: A method of alerting medical personnel of a problem during hemodialysis includes providing an active, fail-to-se site sensor (180) for a fistula needle (150) at an access site during hemodialysis; and automatically alerting medical personnel of a problem during hemodialysis using the active, fail-to-safe site sensor during at least the following: failing of the active, fail-to-safe site sensor; insufficient powering to the active, fail-to-safe site sensor; partial fistula needle dislodging from the access site; and complete needle dislodging from the access site.
Patent CA-2544546-A1 (CA)
Inventor: SIOUI PHIL
IPC: A41D13/05
Filed: 2006-04-21
Abstract: An impact resistant insert for a protective pad and having a stiffener layer of impact resistant, thermoformable material retaining a preset curve at ambient temperature such as to substantially return to the preset curve upon deformation, the stiffener layer becoming temporarily more flexible under heat such that the preset curve can be modified to a different preset curve with the stiffener layer subsequently maintaining the different preset curve at ambient temperature. Also, an impact resistant insert for a protective pad and having a front layer of flexible material, a stiffener layer of multi-cell material having front and rear surfaces with the front surface being connected to the front layer, the stiffener layer being substantially resistant to impact forces, retaining a preset curve and substantially returning to the preset curve upon deformation, and a rear layer of flexible material connected to the rear surface of the stiffener layer.
Patent CA-2545426-A1 (CA)
Inventor: YIN XUEFENG
IPC: G01N33/50
Filed: 2006-05-24
Abstract: Methods for testing and assessing whether an agent that inhibits cdk activity produces a therapeutic response in a mammal, with a focus on detecting the inhibition of phosphorylation of the retinoblastoma protein (Rb) at putative phosphorylation sites, are disclosed. Also disclosed are methods for monitoring pharmacodynamic drug action of a cdk inhibitor in a surrogate tissue(s) of a mammal, preferably a rat, mouse or human.
Patent CA-2548456-A1 (CA)
Title: Combination therapy
Inventor: JOHNSTON PATRICK GERARD
IPC: A61K39/395
Filed: 2004-11-26
Abstract: The invention provides combination therapies and methods for the treatment of cancers associates with p53 mutations. The method comprises the separate, sequential or simultaneous administration of a therapeutically effective amount of a) a specific binding member, for example CH-11, which binds to a cell death receptor, for example Fas, or a nucleic acid encoding said binding member and b) a chemotherapeutic agent, wherein the chemotherapeutic agent is a topoisomerase inhibitor, for example CPT-1 or a thymidylate synthase inhibitor, for example TDX. Synergistic cytotoxic effects have been demonstrated using such combinations.
Patent CA-2549427-A1 (CA)
Inventor: BHAN OPINDER KISHAN
IPC: B01J37/02
Filed: 2004-12-16
Abstract: Contact of a crude feed with one or more catalysts produces a total product that include a crude product. The crude product is a liquid mixture at 25 ~C  and 0.101 MPa. One or more other properties of the crude product may be changed by at least 10% relative to the respective properties of the crude feed.
Patent CA-2550099-A1 (CA)
Title: Two-stage catalytic process for recovering sulfur from an h2s containing gas stream
Inventor: KELLER ALFRED E
IPC: B01D53/86
Filed: 2005-01-13
Abstract: Apparatus and process for recovering elemental sulfur from a H2S-containing waste gas stream are disclosed. The apparatus preferably comprises a first reaction zone (30) for carrying out the catalytic partial oxidation of H2S, a second reaction zone for (40) the catalytic partial reduction of any incidental SO2 produced in the first reaction zone (30), and a cooling zone (320) including a sulfur condenser (380). According to a preferred embodiment of the process, a mixture of H2S and O2 contacts a catalyst in the first reaction zone very briefly (i.e, less than about 200 milliseconds) producing primarily S0 and H2O. Some SO2is also present in the first stage product gas mixture. A reductant gas (e.g, CO, or CH4 or natural gas) is fed together with the first stage product gas mixture to a second catalytic reaction zone where the partial reduction of the SO2 component to elemental sulfur and CO2 is carried out.
Patent CA-2553330-A1 (CA)
Title: Polyformals and copolyformals as a protective layer against hydrolysis on polycarbonate
Inventor: HUFEN RALF
IPC: B65D23/02
Filed: 2005-01-07
Abstract: The invention relates to a multilayered products which are protected against hydrolysis, comprising at least one layer containing a thermoplast and at least one layer containing at least one polyformal or copolyformal, in addition to compositions containing polyformal or copolyformals and possible additives, in addition to the use of polyformals or copolyformals in the production of a layer which protects against hydrolysis.
Patent CA-2554690-A1 (CA)
Inventor: TETHER DAVID EUGENE
IPC: B60W10/08
Filed: 2005-01-28
Abstract: A vehicle or watercraft regeneration system includes at least one electric motor capable of generating electricity and a controller for the at least on e motor; wherein the controller to optimize the efficiency of the regeneration . The controller can optimize efficiency by including comprises circuitry for biasing the electric motor during regeneration. Also provided is a regeneration system that further comprises an electricity storage device suc h as a battery, a capacitor, an electrolysis unit that generates hydrogen from water, and a flywheel. In addition, an efficiency enhancing system for a watercraft or vehicle includes at least one electric motor capable of generating electricity; a controller for the at least one motor; and an electrical connection between the at least one motor and the controller, whe re in the controller adjust one or more magnetic fields of the electric motor during regeneration to optimize the efficiency of the regeneration. Methods for increasing efficiency of regeneration of a watercraft of vehicle powered by at least one electric motor are also disclosed.
Patent CA-2556814-A1 (CA)
Inventor: BERGER MARY
IPC: H01J61/34
Filed: 2006-08-23
Abstract: A metal halide arc discharge lamp (10) having a lamp envelope (12) and an arc tube (14) mounted within the envelope; a shroud (20) surrounding the arc tube (14);  electrical lead-ins (26, 28) for supplying electrical energy to the arc tube (14); and a chemical fill within the arc tube to produce light when an arc is formed within the arc tube; the improvement comprising: the shroud (20) having a given thickness T and a given inside diameter ID  having a relationship such that T is less than 2 mm and ID/T is less than 22.
Patent CA-2561039-A1 (CA)
Title: System and method for determining barrier motor parameters without using sensors
Inventor: GREGORI ERIC MICHAEL
IPC: E05F15/10
Filed: 2006-09-27
Abstract: A barrier operator comprises a first measuring apparatus for measuring a current used by a direct current (dc) motor to move a barrier and a second measuring apparatus for measuring a generated voltage of the dc motor. A controller is coupled to the first measuring apparatus and the second measuring apparatus. The controller is programmed to calculate a torque of the dc motor by using the current and to determine when an obstruction exists in the path of the barrier based upon the calculated torque.
Patent CA-2561697-A1 (CA)
Inventor: NAESS JON ALEKSANDER
IPC: G09B19/00
Filed: 2005-03-30
Abstract: Toilet training aides, toilet training kits and related bathroom training aides and kits are disclosed. Toilet training aides may take the form of a multiple page booklet such a passport like booklet. The pages of the booklet may have a series of iconic images each depicting a toilet activity to a pre-literate or semi-literate child. Associated with each iconic image is a progress indicating area in which success indicating means may be placed for successful completion of the represented activity. Kits can include personal hygiene products ergonomically adapted to be used by a child. The aides and kits disclosed motivate and instruct a toddler or young child on all aspects of toilet training in both a comprehensive and focused manner.
Patent CA-2562343-A1 (CA)
Inventor: MENDRICK DONNA
IPC: G01N33/52
Filed: 2005-04-07
Abstract: The present invention includes methods of predicting hepatotoxicity of test agents and methods of generating hepatotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.
Patent CA-2562789-A1 (CA)
Title: Herbal composition
Inventor: HILTERMAN KARINA ANNA
IPC: A61K36/00
Filed: 2004-04-14
Abstract: The invention relates to a herbal composition comprising extracts from Thuja, Bupleurum, Echinacea, Calendula, Licorice and Hypercum; formulations containing the herbal composition; and use of the herbal composition for alleviating, treating and/or preventing sypmtoms associated with or caused by viral infections
Patent CA-2563684-A1 (CA)
Title: Preventive and/or therapeutic agent for chronic sinusitis
Inventor: SUGIMACHI NAHO
IPC: C07D313/12
Filed: 2005-04-21
Abstract: A preventive and/or therapeutic agent for chronic sinusitis which contains as an active ingredient a dibenzo[b,e]oxepine derivative represented by the following formula (I) (wherein R1, R2, and R3 are the same or different and each represents hydrogen or lower alkyl; and m and n are the same or different and each is an integer of 1-4) or a pharmacologically acceptable salt of the derivative. (I)
Patent CA-2565344-A1 (CA)
Inventor: NOCCA DAVID JEAN-MARIE
IPC: A61F2/04
Filed: 2005-05-17
Abstract: The inventive strip is made of a resorbable material and colonisable by fibroblasts comprises a closure for connecting two ends, thereby securing an anastomosis.
Patent CA-2566665-A1 (CA)
Title: Reduction of the shrinkage force of tooth fillings
Inventor: HOFFMANN MARCUS
IPC: A61K6/884
Filed: 2006-10-27
Abstract: A self-curing or dual-curing, low viscosity composite is used for the fabrication of a dental liner capable of polymerization in 2 stages with 2 curing times and delayed polymerization character-istics that is designed for use at the cavity wall in the form of a thin layer.
Patent CA-2567066-A1 (CA)
Inventor: SMITH RICHARD PETER
IPC: H01L29/778
Filed: 2005-02-09
Abstract: Transistor fabrication includes forming a nitride-based channel layer on a substrate, forming a barrier layer on the nitride-based channel layer, forming a contact recess in the barrier layer to expose a contact region of the nitride-based channel layer, forming a contact layer on the exposed contact region of the nitride-based channel layer, for example, using a low temperature deposition process, forming an ohmic contact on the contact layer and forming a gate contact disposed on the barrier layer adjacent the ohmic contact. A high electron mobility transistor (HEMT) and methods of fabricating a HEMT are also provided. The HEMT includes a nitride-based channel layer on a substrate, a barrier layer on the nitride-based channel layer, a contact recess in the barrier layer that extends into the channel layer, an n-type nitride-based semiconductor material contact region on the nitride-based channel layer in the contact recess, an ohmic contact on the nitride-based contact region and a gate contact disposed on the barrier layer adjacent the ohmic contact. The n-type nitride-based semiconductor material contact region and the nitride-based channel layer include a surface area enlargement structure.
Patent CA-2570363-A1 (CA)
Title: Indoles useful in the treatment of inflammation
Inventor: KATKEVICS MARTINS
IPC: A61P29/00
Filed: 2005-06-17
Abstract: There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.