Patent SG-11201901700U-A (SG)
Title: Biaryl compounds useful as immunomodulators
Inventor: YEUNG KAP-SUN
IPC: C07D417/12
Filed: 2017-08-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1#11101111 0 11101 HOE HI 1 0 011101 111011111011011 HMI MAMIE International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2018/044963 Al 08 March 2018 (08.03.2018) WIP0 I PCT (51) International Patent Classification: Connecticut 06473 (US). SAULNIER, Mark G.; c/o Bris- CO7D 403/12 (2006.01) C07D 401/04 (2006.01) tol-Myers Squibb Company, 5 Research Parkway, Walling- C07D 401/12 (2006.01) C07D 239/26 (2006.01) ford, Connecticut 06492 (US). FRENNESSON, David C07D 207/12 (2006.01) C07D 405/06 (2006.01) B.; c/o Bristol-Myers Squibb Company, 5 Research Park- C07C 211/08 (2006.01) C07C 235/74 (2006.01) CO7D 211/22 (2006.01) CO7D 277/28 (2006.01) way, Wallingford, Connecticut 06492 (US). LANGLEY, David R.; c/o Bristol-Myers Squibb Company, 5 Re- CO7D 213/38 (2006.01) CO7D 417/12 (2006.01) search Parkway, Wallingford, Connecticut 06492 (US). CO7C 211/06 (2006.01) A61K 31/496 (2006.01) HEWAWASAM, Piyasena; 31 Brookview Lane, Middle- CO7C 237/08 (2006.01) A61K 31/4025 (2006.01) town, Connecticut 06457 (US). WANG, Tao; c/o Bris- CO7D 211/46 (2006.01) A61K 31/454 (2006.01) tol-Myers Squibb Company, 5 Research Parkway, Walling- CO7D 211/58 (2006.01) A61K 31/4725 (2006.01) ford, Connecticut 06492 (US). ZHANG, Zhongxing; c/ CO7D 211/60 (2006.01) A61K 31/5377 (2006.01) CO7D 211/66 (2006.01) A61K 31/4439 (2006.01) o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). MENG, Zhaoxing; CO7D 213/85 (2006.01) A61K 31/4155 (2006.01) C07C 211/26 (2006.01) A61K 31/4409 (2006.01) c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 (US). SUN, Li-Qiang; CO7C 211/35 (2006.01) A61K 31/4178 (2006.01) c/o Bristol-Myers Squibb Company, 5 Research Park- CO7D 405/12 (2006.01) A61K 31/397 (2006.01) way, Wallingford, Connecticut 06492 (US). MULL, Er- CO7D 205/04 (2006.01) A61K 31/415 (2006.01) ic; c/o Bristol-Myers Squibb Company, 5 Research Park- CO7D 213/42 (2006.01) A61K 31/505 (2006.01) way, Wallingford, Connecticut 06492 (US). SCOLA, Paul CO7D 401/14 (2006.01) A61K 31/426 (2006.01) Michael; c/o Bristol-Myers Squibb Company, 5 Research C07C 211/29 (2006.01) A61K 31/541 (2006.01) Parkway, Wallingford, Connecticut 06492 (US). CO7D 207/14 (2006.01) A61P 35/00 (2006.01) CO7D 213/55 (2006.01) A61P 35/02 (2006.01) Agent: MINGO, Pamela A. Bristol-Myers Squibb (74) et al.; CO7D 231/12 (2006.01) A61P 37/04 (2006.01) Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (21) International Application Number: PCT/US2017/049252 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, International Filing Date: 30 August 2017 (30.08.2017) (22) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, Priority Data: 62/382,480 01 September 2016 (01.09.2016) US 15/689,115 29 August 2017 (29.08.2017) US (30) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY (84) Designated States (unless otherwise indicated, for every [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: YEUNG, Kap-Sun; c/o Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecti- cut 06492 (US). GRANT-YOUNG, Katharine A.; 1343 Boston Post Road, Unit 208, Madison, Connecticut 06443 (US). ZHU, Juliang; 22 Windsor Road East, North Haven, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 (54) Title: BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS (57) : The present disclosure generally relates to compounds useful as immunomodulators. en V;) R Provided herein are compounds, compositions comprising such compounds, and methods of their 01 j use. The disclosure further pertains to pharmaceutical compositions comprising at least one com- 71' pound according to the disclosure that are useful for the treatment of various diseases, including 71' 0 --.... cancer and infectious diseases. 1-1 (1) 0 ei C [Continued on next page] WO 2018/044963 Al MIDEDIMOMOIDEIREEMOMMEM0110110MOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))