baber/WOPTO huggingface dataset:
Patent WO-2019126039-A1 (WO)
Title: Dispositifs de commande de lumière et procédés de variation régionale d'informations visuelles et d'échantillonnage
Inventor: SERDAREVIC OLIVIA
IPC: G02B26/02
Filed: 2018-12-17
Abstract: L'invention concerne des dispositifs et des procédés de commande de lumière donnés à titre d'exemple, fournissant une variation régionale d'informations visuelles et d'échantillonnage ("V-VIS") d'un champ de vision oculaire qui améliore ou stabilise la vision, améliore un symptôme visuel, réduit le taux de perte de vision ou réduit la progression d'une affection, d'une maladie, d'une lésion ou d'un trouble ophtalmique ou neurologique. Les dispositifs et les procédés V-VIS peuvent déplacer optiquement, à une fréquence d'échantillonnage comprise entre 50 hertz et 50 kilohertz, une ou plusieurs ouvertures antérieures à une rétine, entre une ou plusieurs positions antérieures à la rétine qui sont non coaxiales avec un centre d'une pupille et une position antérieure à la rétine qui est coaxiale avec le centre de la pupille. Certains des dispositifs et procédés V-VIS peuvent être combinés à la réalité augmentée ou virtuelle, à la mesure de la vision, à la surveillance de la vision ou à d'autres thérapies comportant, mais sans s'y limiter, des thérapies pharmacologiques, géniques, de remplacement rétinien et de cellules souches.
Patent WO-2019136201-A1 (WO)
Inventor: KASPRZAK TIMOTHY PHILLIP
IPC: G06Q50/26
Filed: 2019-01-04
Abstract: A system and method for triaging vehicular accidents that utilizes various data collected from vehicles during a collision, and data collected from patient trauma grading of passengers in vehicular collisions, while patients are treated at hospitals or other trauma centers, to triage subsequent accident victims in real-time. The vehicle data is correlated with the patient data to generate a probability algorithm of the severity and type of injury likely resulting from a collision as indicated by the vehicle data. This predictive model can be generated for medical personnel and communities to use to intelligently triage passengers in a collision, i.e., dispatch appropriate response resources, alert nearby hospitals, etc. The vehicle is capable of automatically transmitting the probability of severity of injuries for the passengers to the community emergency response services so that medical personnel and communities may prioritize resources and the location to which said passengers are transported.
Patent WO-2019147820-A1 (WO)
Title: Eccentric reaming tool
Inventor: TEODORESCU SORIN
IPC: E21B10/16
Filed: 2019-01-24
Abstract: A reaming tool for use in a wellbore has an elongated tubular body with an outer surface. There are at least first and second reamer sections formed on the tubular body, with the first and second reamer sections (i) being positioned circumferentially opposite one another, and (ii) each having at least two blades. The first reamer section includes at least one rounded dome insert and a majority of cutting tooth inserts, while the second reamer section includes a majority of rounded dome inserts.
Patent WO-2019157428-A1 (WO)
Inventor: MATSUDA KAZUKO
IPC: A61P31/04
Filed: 2019-02-11
Abstract: L'invention concerne des méthodes de suppression de cellules suppressives myéloïdes (MDSC), de réduction de la suppression immunitaire, de réduction du nombre de lymphocytes T régulateurs et d'augmentation du nombre de lymphocytes T CD4+ chez des patients atteints d'un cancer en faisant appel à l'ibudilast.
Patent WO-2019160910-A1 (WO)
Title: Fibroblast growth factor analogs and uses thereof
Inventor: OKUNIEFF PAUL GERSON
IPC: C07K14/50
Filed: 2019-02-13
Abstract: Disclosed herein are peptide analogs of human FGF. These peptide analogs exhibit improved therapeutic activity and fewer side effects when used in humans. Also disclosed are pharmaceutical or cosmetic compositions comprising the FGF analogs and pharmaceutically or cosmetically acceptable carriers or excipients. Also provided are methods of treating or preventing a disease in a subject that involves administering to the subject the disclosed FGF analogs.
Patent WO-2019165168-A1 (WO)
Title: Novel cas9 orthologs
Inventor: HOU ZHENGLIN
IPC: C12N15/113
Filed: 2019-02-22
Abstract: Compositions and methods are provided for novel Cas9 orthologs, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The present disclosure also describes methods for creating a double strand break in a target polynucleotide, methods for genome modification of a target sequence under various in vivo and in vitro conditions, in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell. Also provided are nucleic acid constructs and cells having a modified target site or altered polynucleotide of interest produced by the methods described herein.
Patent WO-2019169015-A1 (WO)
Inventor: CONNELLY STEPHEN
IPC: C07K16/28
Filed: 2019-02-27
Abstract: The disclosure provides compositions and methods related to treating, ameliorating, and preventing asthma, and in particular steroid resistant or refractory severe asthma, with an anti-CD6 antibody, itolizumab, or an antigen binding portion thereof, alone or in combination with other agents useful in treating asthma.
Patent WO-2019173155-A1 (WO)
Title: Tailoring sensor emission power to map, vehicle state, and environment
Inventor: HERMALYN BRENDAN
IPC: G05D1/02
Filed: 2019-03-01
Abstract: The present disclosure relates to systems and methods that facilitate active sensor systems. An example method includes receiving information indicative of an operating context of a vehicle, wherein at least one Light Detection and Ranging (LIDAR) sensor or at least one radar sensor are coupled to the vehicle. The method also includes selecting, from a plurality of sensor power configurations, a desired sensor power configuration based on the operating context of the vehicle. The method further includes causing at least one of: the at least one LIDAR sensor to emit light pulses according to the desired sensor power configuration or the at least one radar sensor to emit radar energy according to the desired sensor power configuration.
Patent WO-2019169400-A1 (WO)
Inventor: O'SHEA TIM
IPC: G06N3/08
Filed: 2019-03-04
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over RF channels. In some implementations, information is obtained. An encoder network is used to process the information and generate a first RF signal. The first RF signal is transmitted through a first channel. A second RF signal is determined that represents the first RF signal having been altered by transmission through the first channel. Transmission of the first RF signal is simulated over a second channel implementing a machine-learning network, the second channel representing a model of the first channel. A simulated RF signal that represents the first RF signal having been altered by simulated transmission through the second channel is determined. A measure of distance between the second RF signal and the simulated RF signal is calculated. The machine-learning network is updated using the measure of distance.
Patent WO-2019173743-A1 (WO)
Title: Proteomic assay using quantum sensors
Inventor: CLEVELAND JASON PAUL
IPC: G01N21/78
Filed: 2019-03-08
Abstract: Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.
Patent WO-2019178468-A1 (WO)
Title: Baseball swing training device
Inventor: KIBBE ROBERT NICHOLAS
IPC: A63B69/40
Filed: 2019-03-15
Abstract: A baseball swing training device has a base, a support member adjustably connected to the base, and a suction assembly disposed in the base that extends through and out of the support member to hold a ball in a stationary position. The suction assembly includes a coil vacuum hose disposed within the support member, and connected to a vacuum pump assembly, and an elongated hose connected to the coil vacuum hose at one end, and removeably connected to a suction nozzle at an opposite end.
Patent WO-2020040816-A1 (WO)
Title: System and method for utilizing pressure decay to determine available fluid capacity in a negative pressure dressing
Inventor: LONG JUSTIN A
IPC: A61M1/00
Filed: 2019-03-25
Abstract: A negative pressure wound therapy system includes at least one sensor (126) coupled to a wound dressing (104) for a wound of a patient, and a processing circuit (146). The at least one sensor (126) is configured to output a measurement of the pressure in the wound dressing (104). The processing circuit (146) is configured to open a sealable aperture (118), receive the pressure measurements in the wound dressing (104), calculate a rate of pressure decay, correlate the rate of pressure decay in the wound dressing (104) to a wound dressing fluid absorbent capacity and other therapy parameters, and output the wound dressing fluid absorbent capacity and other therapy parameters to a remote electronic device.
Patent WO-2019199503-A1 (WO)
Title: Systems and methods of displaying virtual elements on a multipositional display
Inventor: GURR KAE-LING JACQULINE
IPC: G06F1/16
Filed: 2019-04-01
Abstract: A method of presenting visual information to a user includes detecting a position of a display relative to a surrounding environment, detecting movement of the display relative to the surrounding environment in real time, and updating a presentation of visual information on the display relative to a virtual reference frame updated in real time based upon the movement of the display relative to the surrounding environment.
Patent WO-2020204912-A1 (WO)
Title: Radio frequency power amplifier with adjustable power supply
Inventor: ZHENG YI
IPC: H03G3/10
Filed: 2019-04-02
Abstract: A semiconductor device includes at least one RF power amplifier (RFPA) and a voltage supply adjustment network coupled with the RFPA for providing an internal supply voltage to the RFPA based on an applied input voltage. The voltage supply adjustment network includes multiple resistors, multiple Zener diodes, a voltage return connection, an internal supply voltage connection coupled with the RFPA for conveying the supply voltage to the RFPA, an input voltage connection adapted to receive the input voltage, and a configurable connection network coupled with the resistors and Zener diodes. A subset of the resistors and Zener diodes are selectively connected together between the input voltage and the voltage return connections via corresponding conductive links to provide a prescribed output voltage to the internal supply voltage connection as a function of the applied input voltage. The connection network is configured by applying an energy source to a selected conductive link(s) in the connection network.
Patent WO-2019200043-A1 (WO)
Inventor: TARTIS MICHAELANN
IPC: A61K47/54
Filed: 2019-04-11
Abstract: La présente invention concerne la synthèse et l'utilisation de promédicaments lipidiques qui s'auto-assemblent en liposomes ou microbulles lipidiques. Les microbulles ou liposomes chargés de promédicament peuvent être activés de manière intracellulaire à l'aide d'un stimulus externe, par exemple, à l'aide d'ondes ultrasonores.
Patent WO-2019204594-A1 (WO)
Title: Cooling electronic devices in a data center
Inventor: EDWARDS WILLIAM
IPC: H05K7/20
Filed: 2019-04-18
Abstract: A data center cooling system includes a server rack sub-assembly that includes a motherboard mounted on a support member and a heat generating electronic devices mounted on the a motherboard; a cold plate positioned in thermal communication with at least a portion of the heat generating electronic devices, the cold plate configured to receive a flow of a cooling liquid circulated through a supply conduit fluidly coupled to a liquid inlet of the cold plate, through the cold plate, and through a return conduit fluidly coupled to a liquid outlet of the cold plate; and a modulating control valve attached to either of the motherboard or the support member and positioned in either of the supply conduit or the return conduit, the modulating control valve configured to adjust a rate of the flow of the cooling liquid based on an operating condition of at least one of the heat generating electronic devices.
Patent WO-2019209778-A1 (WO)
Title: Broadcast transmission by relay node
Inventor: KALHAN AMIT
IPC: H04L1/00
Filed: 2019-04-23
Abstract: A donor communication station transmits a unicast transmission comprising a plurality of device data sets where each device data set directed to each of a plurality of user equipment (UE) devices. A relay node receives the unicast transmission and retransmits the data sets in a broadcast transmission over a broadcast communication channel to the plurality of UE devices. In one example, the donor communication station encodes data for multiple user equipment (UE) devices by applying broadcast encoding to the data for each device before applying outer encoding to the data. The dual encoded data is transmitted to the relay node over a dedicated channel. The relay node applies outer decoding to the dual encoded data to retrieve the broadcast encoded data. The relay node then transmits the broadcast encoded device data in a broadcast transmission without outer encoding.
Patent WO-2019210042-A1 (WO)
Title: Expression of foxp3 in edited cd34+ cells
Inventor: RAWLINGS DAVID J
IPC: C07K14/47
Filed: 2019-04-25
Abstract: Aspects of the invention described herein concern the incorporation of a FOXP3 cDNA (e.g., full-length human codon-optimized cDNA) into a  FOXP3  gene or a non- FOXP3  locus so as to provide constitutive or regulated FOXP3 expression in a primary human CD34 +  cells or cells derived from edited CD34 +  cells. In some embodiments, guide RNA sequences that are directed to FOXP3, AAVS1, or other candidate loci are used for CRISPR/Cas9-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided.
Patent WO-2019217184-A1 (WO)
Title: Intramedullary nail
Inventor: GIORDANO MICHAEL
IPC: A61B17/17
Filed: 2019-05-02
Abstract: Apparatus and methods for an intramedullary nail. Preferably, the nail includes three components, including two longitudinal sections that are slidable relative to one another, so as to not restrain any growth of the bone. A third threaded member is rotatably coupled to one of the sliding pieces, and the other of the sliding pieces includes a threaded end. The nail is threadably coupled to a bone. Other embodiments include a bone fastener that can be coupled to different bones or bone fragments, maintaining the two different bone pieces rotationally stable relative to one another, but permitting growth between the two bones.
Patent WO-2019217415-A1 (WO)
Title: Connector assembly for an electrical stimulation system
Inventor: STINAUER ROBERT
IPC: A61N1/375
Filed: 2019-05-07
Abstract: A connector assembly for an implantable device includes a feedthrough interface having a ceramic feedthrough and a ferrule attached to, and forming a perimeter around, the ceramic feedthrough; a lower contact housing coupled to the feedthrough interface, where the lower contact housing and ceramic feedthrough define wire holes extending therethrough; an upper contact housing attached to the lower contact housing and collectively defining contact receptacles, each of the contact receptacles defining an opening for at least one of the wire holes; connector contacts with each connector contact disposed in a one of the contact receptacles; and wires with each of the wires coupled to one of the connector contacts and extending through one of the wire holes so that the respective wire extends out of the ceramic feedthrough.
Patent WO-2019226505-A1 (WO)
Title: Drill bit for use with intensified fluid pressures
Inventor: PORTWOOD GARY R
IPC: E21B41/00
Filed: 2019-05-20
Abstract: A cutting bit includes a bit body and high-pressure body with a high-pressure fluid conduit therethrough. The high-pressure body and bit body are joined together. The high-pressure fluid conduit is configured to convey a fluid at greater than 14.5 ksi, and in some embodiments greater than 40 ksi. The high-pressure fluid conduit may direct the fluid through a nozzle in a fluid jet to weaken material, such as an earth formation. The cutting bit includes at least one roller cone and/or blades with cutting elements thereon to remove the weakened material. A cutting bit includes both high and low-pressure fluid conduits, and high and low-pressure fluid nozzles. The high-pressure nozzles receive fluid flow from a downhole pressure intensifier, and a connection between the bit and the downhole pressure intensifier includes rigid connectors, flexible connectors, or a combination thereof.
Patent WO-2019222755-A1 (WO)
Title: Inverted heart valve for transcatheter valve replacement
Inventor: REED ANDREW
IPC: A61B17/34
Filed: 2019-05-20
Abstract: A system for endovascular heart valve repair, the system comprising: a delivery catheter comprising a retractable sheath and a tip near a distal end of the catheter; and a valve assembly disposed within the retractable sheath in a delivery position, the valve assembly comprising: an expandable stent having a proximal end and a distal end, the expandable stent having an outer surface and an inner surface defining a stent lumen; and a valve in an inverted orientation having a proximal end and a distal end, the proximal end of the valve connected to the distal end of the expandable stent, the valve having an outer surface and an inner surface defining a valve lumen, wherein the valve extends distally from the distal end of the expandable stent between the expandable stent and the tip when the valve assembly is in the delivery position.
Patent WO-2020005881-A1 (WO)
Title: Color capture system and device
Inventor: NICHOL JAMIE
IPC: G01J3/50
Filed: 2019-06-25
Abstract: Exemplary embodiments provide a simple, inexpensive, and easy-to- operate color capture device that can capture color information and transmit the captured color information to an interface device such as smartphone, where the captured color information is optionally processed and is then transmitted to a remote server for subsequent production of the customized cosmetic. The device comprisies at least one LED capable of selectively producing red light, green light, and blue light; a light sensor circuit; a loop antenna; and a microcontroller having a timer circuit, the microcontroller comprising stored computer program instructions that, when executed on the microcontroller, causes the microcontroller to implement computer processes for a color capture sequence.
Patent WO-2020010080-A1 (WO)
Title: Methods of producing recombinant proteins
Inventor: XU JIANLIN
IPC: C07K16/00
Filed: 2019-07-02
Abstract: In certain embodiments, this disclosure provides novel methods of increasing the viable cell density of an N-1 large-scale bioreactor cell culture, comprising culturing a host cell expressing a recombinant polypeptide of interest in a non-perfusion-based culture system, and wherein the viable cell density is increased to at least 5 × 10 6  cells/mL. In certain embodiments, the disclosure provides novel methods for large-scale production of a recombinant polypeptide of interest, comprising: (1) culturing a host cell expressing a recombinant polypeptide of interest in an N-1 stage in a non-perfusion-based culture system, wherein the viable cell density is increased to at least 5 × 10 6  cells/mL; and (2) culturing N fed-batch production cells in an enriched media with high-seed density at least 1.5 × 10 6  cells/mL, wherein the N fed-batch production cells are inoculated from the N-1 stage in a non-perfusion-based culture system.
Patent WO-2020018279-A1 (WO)
Title: Building ensembles for deep learning by parallel data splitting
Inventor: BAKER JAMES
IPC: G06N20/00
Filed: 2019-07-02
Abstract: Computer-implemented systems and methods build ensembles for deep learning through parallel data splitting by creating and training an ensemble of up to 2n ensemble members based on a single base network and a selection of n network elements. The ensemble members are created by the "blasting" process, in which training data are selected for each of the up to 2n ensemble members such that each of the ensemble members trains with updates in a different direction from each of the other ensemble members. The ensemble members may also be trained with joint optimization.
Patent WO-2020010139-A1 (WO)
Title: Methods of treating refractory inflammatory disease using transcriptomic and genetic risk signatures
Inventor: POTDAR ALKA
IPC: C12Q1/68
Filed: 2019-07-02
Abstract: Disclosed herein are methods, kits and compositions for treating an inflammatory disease. These methods, kits and compositions may be particularly useful for subjects carrying a risk genotype and/or expressing a transcriptomic risk signature that is indicative of severe inflammatory disease phenotypes for which existing treatment options are limited.
Patent WO-2020028481-A1 (WO)
Title: System for detecting eating with sensor mounted by the ear
Inventor: BI SHENGJIE
IPC: A61B5/103
Filed: 2019-07-31
Abstract: A wearable device for detecting eating episodes uses a contact microphone to provide audio signals through an analog front end to an analog-to-digital converter to digitize the audio and provide digitized audio to a processor; and a processor configured with firmware in a memory to extract features from the digitized audio. A classifier determines eating episodes from the extracted features. In embodiments, messages describing the detected eating episodes are transmitted to a cell phone, insulin pump, or camera configured to record video of the wearer's mouth.
Patent WO-2020033286-A1 (WO)
Title: Novel sesquiterpenoid analogs
Inventor: DAI MINGJI
IPC: A61P3/04
Filed: 2019-08-05
Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.
Patent WO-2020040966-A1 (WO)
Title: Smartphone, system and method comprising a radar system
Inventor: GIUSTI LEONARDO
IPC: G06F3/01
Filed: 2019-08-05
Abstract: This document describes techniques and systems that enable a smartphone, system and method comprising a radar system. The techniques and systems use a radar field to accurately determine three-dimensional (3D) gestures that can be used to interact with augmented-reality (AR) objects that are presented on a display of an electronic device, such as a smartphone. These techniques allow the user to make 3D gestures from a distance—the user does not have to hold the electronic device steady while touching the screen and the gestures do not obstruct the user's view of the AR objects presented on the display.
Patent WO-2020041075-A1 (WO)
Inventor: NEWMAN PHILLIP
IPC: G01S17/89
Filed: 2019-08-14
Abstract: Le nettoyage d'une piscine peut être facilité par des systèmes et des procédés permettant de cartographier un environnement de piscine. Une telle cartographie peut être réalisée le cas échéant dans les trois dimensions. Au moins certains des systèmes peuvent comprendre un appareil de détection de lumière et de télémétrie (LIDAR) (14) attaché à un dispositif automatique de nettoyage de piscine (18).