Patent SG-11201811446S-A (SG)
Title: Process for recovering viral products using functionalised chromatography media
Inventor: SCANLON IAN
IPC: C12N7/00
Filed: 2017-07-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111101 11111111111111 111E1111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/011599 A3 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: C12N 7/02 (2006.01) C12N 7/00 (2006.01) Published: 1301.1 20/285 (2006.01) A61K 48/00 (2006.01) — with international search report (Art 21(3)) — before the expiration of the time limit for amending the (21) International Application Number: claims and to be republished in the event of receipt of PCT/GB2017/052084 amendments (Rule 48.2(h)) (22) International Filing Date: (88) Date of publication of the international search report: 14 July 2017 (14.07.2017) 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1612248.3 14 July 2016 (14.07.2016) GB (71) Applicant: PURIDIFY LTD. [GB/GB]; Stevenage Bio- science Catalyst, Gunnels Wood Road, Stevenage Hertford- shire SG1 2FX (GB). (72) Inventor: SCANLON, Ian; 21 Hayfield Avenue, Sawston Cambridgeshire CB22 3JZ (GB). Agent: NEWMAN, Alastair James Morley; 14 South (74) Square, Gray's Inn, London Greater London WC1R 5JJ (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NE NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) = Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) M ON (54) Title: PROCESS FOR RECOVERING VIRAL PRODUCTS USING FUNCTIONALISED CHROMATOGRAPHY MEDIA 01 in (57) : The present invention provides a process for recovering a viral product from a composition comprising said product 1-1 and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium 1 8 comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral ---. cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which GC ., contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, 1:::: ) virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or N proviruses, each of which is substantially devoid of polynucleotides. O