Patent AU-2012324029-B2 (AU)
Title: Polymorphs of CDDO ethyl ester and uses thereof
Inventor: ZHANG XIAOHONG
IPC: C07J63/00
Filed: 2012-12-06
Granted: 2015-05-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2014/048033 A1 3 April 2014 (03.04.2014) WI PO I P CT (51) International Patent Classification: C1O-1, BDA, 2 North Jingyuan St., Beijing 100176 (CN). C07J63/00 (2006.01) A61P3/04 (2006.01) HAN, Chunlei; C1O-1, BDA, 2 North Jingyuan St., A61K 31/56 (2006.01) A61P 9/12 (2006.01) Beijing 100176 (CN). A61P 35/00 (2006.01) A61P 9/10 (2006.01) (74) Agents: CHEN & PARTNERS et al.; B402, 4/F, Tower A61P 29/00 (2006.01) A61P 13/12 (2006.01) B, Beichen Huixin Plaza, 8 Beichen East Rd., Chaoyang A61P 19/02 (2006.01) A61P 25/00 (2006.01) District, Beijing 100101 (CN). A61P 1/00 (2006.01 ) A61P 27/02 (2006.01 )' ' A61P 9/00 (2006.01) A61P 3/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 3/10 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number. AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/CN2012/086045 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 6 December 2012 (06.12.2012) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. PCT/CN2012/082278 28 September 2012 (28.09.2012) CN (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: APPLIED PHARMACEUTICAL SCI- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, ENCE, INC. [CN/CN]; C1O-1, BDA, 2 North Jingyuan UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, St., Beijing 100176 (CN). WANG, Zhijian [CN/CN]; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, C10-1, BDA, 2 North Jingyuan St., Beijing 100176 (CN). EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventor; and MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (71) Applicant: ZHANG, Xiaohong [US/CN]; C1O-1, BDA, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 2 North Jingyuan St., Beijing 100176 (CN). ML, MR, NE, SN, TD, TG). (72) Inventors: LU, Song; C1O-1, BDA, 2 North Jingyuan St., Published: Beijing 100176 (CN). SUN, Wendong; C10-1, BDA, 2 - with international search report (Art. 21(3)) North Jingyuan St., Beijing 100176 (CN). LIU, Kaiyang; (54) Title: POLYMORPHS OF CDDO ETHYL ESTER AND USES THEREOF CO2Et NC (57) Abstract: The present invention relates to polymorphic forms of the compound of Formula (I) (i.e., ethyl 2-cyano-3,12-diox O oleana-1,9(ll)-dien-28-oate (CDDO ethyl ester)) and methods of using them for treating a variety of disease states such as cancer and condisitons associated with inflammation.