baber/WOPTO huggingface dataset:
Patent CA-2477981-A1 (CA)
Title: Intra-ventricular pressure sensing catheter
Inventor: ROSENBERG MEIR
IPC: A61M25/00
Filed: 2004-08-18
Abstract: An infra-ventricular pressure sensor device is provided that includes a catheter having a first lumen for receiving fluid flow therethrough, and a second, separate, fluid-filled, fluid-impermeable lumen extending between a pressure-sensitive component that is adapted to be exposed to an external pressure source, and a pressure sensor that is effective to measure pressure of the external pressure source in response to displacement of the pressure-sensitive component. The infra-ventricular pressure sensor device is particularly advantageous in that it allows a direct measurement of a patient's ventricular pressure to be obtained.
Patent CA-2479540-A1 (CA)
Inventor: AMATEAU MAURICE F
IPC: B23F5/00
Filed: 1993-08-19
Abstract: An apparatus and method are provided for the thermomechanical net shape finishing of precision gear tooth surfaces by controlled deformation into the metastable austenitic condition. To this end, an arrangement of a fixed axis through-feed motion of workpiece and moving axes in-feed motion of two opposed rolling dies are utilized. By means of process control methods and architecture for accomplishing precise mechanical motions, thermal and environmental control, and timely and automatic transfer of workpieces, high strength and high accuracy gear tooth surfaces can be produced.
Patent CA-2480009-A1 (CA)
Title: Bath apparatus with therapy centers
Inventor: TO ALEX WONG CHI
IPC: A61H7/00
Filed: 2003-03-28
Abstract: An apparatus (10) is provided for bathing body parts (F), such as the feet (F). The apparatus (10) includes a bath chamber (12) for containing fluid, such as water, and receiving the body (F) part therein. The bath chamber (12 ) includes a bottom surface (14) and a wall structure (16) extending upwardly therefrom. A hood (30) is attached to the wall structure (16) and is arrange d to at least partially cover the bath chamber (12), and a motor (62) is mount ed on an underside of the hood (30). At least two spaced therapy centers (31) a re disposed on the hood (30), where the therapy centers (31) are operably connected (66,68,70,72,74,76,78 ) to the motor (62) for providing therapy to the body part (F) when the body part (F) is placed on one of the therapy centers (31).
Patent CA-2484303-A1 (CA)
Inventor: CLEVELAND MARK VB
IPC: A61P1/10
Filed: 2003-04-28
Abstract: Dans le domaine du diagnostic et des procédures chirurgicales côloniques, le manque de moyens optimaux disponibles pour le nettoyage du côlon constitue un obstacle. Il a fallu trouver un compromis entre des solutions hyperosmotiques, solides ou à volume réduit, pratiques mais désagréables, qui provoquent d'importants déséquilibres fluidiques et électrolytiques chez les patients et des solutions iso-osmotiques, à grand volume, difficiles à consommer. L'invention décrit une solution hyperosmotique à volume réduit constituée de sels de sulfate avec et sans polyéthylèneglycol. Contrairement à ce qui était le cas dans la technique antérieure, cette composition est utile pour le nettoyage des intestins et, à volumes réduits, constitue un laxatif efficace, sans entraîner de changements significatifs du point de vue clinique dans la fonction corporelle.
Patent CA-2484827-A1 (CA)
Inventor: TARRO GIULIO
IPC: A61P31/14
Filed: 2003-05-05
Abstract: Glyoxal derivatives for use in the prevention and treatment ofRhinovirus infections are herein disclosed.
Patent CA-2487033-A1 (CA)
Title: Amide substituted xanthine derivatives with gluconeogenesis modulating activity
Inventor: PIETRANICO-COLE SHERRIE LYNN
IPC: C07D473/04
Filed: 2003-06-05
Abstract: The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
Patent CA-2488249-A1 (CA)
Inventor: MITCHELL LLOYD G
IPC: A61K31/7088
Filed: 2003-06-05
Abstract: La présente invention concerne des méthodes et des compositions permettant de générer de nouvelles molécules d'acides nucléiques par le biais du transépissage de l'ARN par épisséome ciblé dans des cellules souches. Ces compositions contiennent des cellules souches mises au point pour exprimer des molécules de pré-transépissage (PTM) élaborées pour interagir avec une molécule d'ARN messagère précurseur cible (pré-ARNm ciblé) et elles médient une réaction de transpéissage débouchant sur la génération de nouvelles molécules d'ARN recombinant (ARN recombinant). Notamment, les cellules souches de cette invention sont génétiquement modifiées pour exprimer une molécule de transépissage qui interagit avec un pré-ARNm cible spécifique exprimé au sein d'une cellule souche, à mesure qu'elle se différencie, afin de parvenir à la correction d'un défaut génétique responsable d'un trouble génétique. Ces méthodes consistent à transférer une molécule d'acide nucléique capable de coder une molécule de transépissage (PTM) d'intérêt dans une cellule souche suite à une transplantation de la cellule souche modifiée de la molécule de transépissage (PTM) dans un hôte. A mesure que la cellule souche se différencie, le pré-ARNm cible est exprimé, ce qui permet d'engendrer le substrat pour une réaction de transépissage. Ladite méthode de cette invention repose sur le transfert réussi et l'expression d'une molécule d'acide nucléique codant une molécule de transépissage (PTM) capable d'interagir avec un pré-ARNm régulateur de la conductance transmembranaire d'une fibrose cystique dans des cellules progénitrices des voies aériennes humaines primaires. Ces méthodes et ces compositions peuvent être utilisées pour corriger des défauts génétiques liés à une variété de troubles différents, tels que la fibrose cystique, l'hémophilie, la dépranocytose, la maladie de Tay-Sachs, les thalassémies, la maladie de rein polykystique, la dystrophie musculaire, pour en citer quelques uns.
Patent CA-2490545-A1 (CA)
Title: Transdermal drug delivery devices having coated microprotrusions
Inventor: DADDONA PETER E
IPC: A61K47/38
Filed: 2003-06-27
Abstract: Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.
Patent CA-2491826-A1 (CA)
Inventor: VENKATESAN RAMARATHNAM
IPC: G06T1/00
Filed: 2005-01-10
Abstract: A desynchronized fingerprinting method and system for identifying collaborators in the making of illegal copies of digital multimedia products.  The desynchronized fingerprinting system and method can be used for both audio and video applications. The method and system include an embedding feature and a detection and extraction feature. A different and unique key is assigned to each buyer of a copy of the digital data. The embedding feature includes applying a pseudo-random transformation to selected embedding regions. The key for the pseudo-random transform is user-specific. These regions are chosen by using a secure multimedia hash function. The detection and extraction feature includes a brute-force search in the key space of the buyers. If one of the keys is likely enough, then it can be said that that user was been involved in the production of an illegal copy.
Patent CA-2491906-A1 (CA)
Inventor: VAN DER VEEN H MONIQUE
IPC: A61B1/24
Filed: 2003-07-30
Abstract: Described are dental implements useful for inspecting tooth surfaces for abnormalities such as caries or plaque. Preferred implements of the invention include light-emitting diodes mounted on an implement body having a mirror for insertion into a user's mouth. Such implements also have on-board batteries mounted in chambers in the implement handle, and a switch for energizing and de-energizing the LED with the battery. Also described are methods for examining tooth surfaces for abnormal conditions indicative of plaque involving illuminating surfaces with radiation at a wavelength in the range of 390-450 nm wherein the radiation is effective to cause detectable fluorescence emissions from bacterial metabolites known to be associated with plaque-containing surfaces, and detecting the emissions.
Patent CA-2493849-A1 (CA)
Inventor: FISCHER ANDREW J
IPC: C12N5/02
Filed: 2003-07-11
Abstract: L'invention concerne un système de culture cellulaire se rapportant à la culture in vitro étendue de cellules neuronales matures, ainsi que des procédés de préparation de ce système. Dans un mode de réalisation préféré, l'invention concerne un système de culture cellulaire comprenant un mélange de cellules neuronales matures de la rétine et de cellules isolées d'un corps ciliaire. L'invention concerne également des procédés permettant d'identifier des agents bioactifs qui modifient la neurodégénération des cellules neuronales de la rétine.
Patent CA-2499150-A1 (CA)
Title: Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
Inventor: TAYLOR GAYLE E
IPC: A61K31/4162
Filed: 2003-09-17
Abstract: The present invention encompasses compounds of Formula I: or pharmaceuticall y acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
Patent CA-2501396-A1 (CA)
Title: Lens care composition and method
Inventor: TSAO FU-PAO
IPC: A61L12/08
Filed: 2003-12-12
Abstract: An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective against C. albicans within 15 minutes of contact.
Patent CA-2503869-A1 (CA)
Inventor: PIESCHEL FRANK
IPC: B62D63/06
Filed: 2005-04-07
Abstract: A dumping cart having an article retaining bed, a chassis, a front set of wheels, a rear set of wheels, and a mechanism for pulling. The article retaining bed has a front end, a rear end, a pair of sides that each extend between the front end and the rear end. The front set of wheels is operably attached to the chassis. The rear set of wheels is operably attached to the article retaining bed proximal to the rear end. The mechanism for pulling the dumping cart is operably attached to at least one of the article retaining bed and the chassis. The chassis is pivotally attached to the article retaining bed intermediate the front set of wheels and the rear set of wheels.
Patent CA-2507227-A1 (CA)
Title: Facsimile to e-mail communication system with local interface
Inventor: BLOOMFIELD MARK C
IPC: H04L12/54
Filed: 1997-10-07
Abstract: A fax to E-mail system and related method are shown, whereby a hardcopy document is sent via a fax device to its recipient via electronic mail through a data network (such as the Internet), and is delivered in such a manner that it can be retrieved by the recipient at an E-mail device, in the ordinary course of retrieving the E-mail, and displayed on the screen of the E-mail device. The invention provides for and accomplishes the delivery of a document, which begins as a hardcopy, as an electronic file retrieved through E-mail recipient's terminal and displayed on the computer screen of the E-mail recipient's terminal. The system and method also provides for an interface device which connects to a conventional fax device for communicating E-mail addresses and routing hardcopy documents to the E-mail network. The invention provides a means for embedding the functions of the interface device into conventional fax devices. The system can also be used in cooperation with Internet Web service for reporting, accounting, information services, and user interaction.
Patent CA-2508990-A1 (CA)
Inventor: NGUYEN-BA NGHE
IPC: A61K31/454
Filed: 2003-12-09
Abstract: L'invention concerne des nouveaux composés représentés par la formule (I) ou des sels acceptables sur le plan pharmaceutique de ceux-ci, qui sont utiles pour le traitement d'infections virales liées aux Flaviviridae.
Patent CA-2510244-A1 (CA)
Inventor: PAVLOV PAUL
IPC: A61F2/44
Filed: 2002-12-17
Abstract: L'invention concerne un implant intervertébral (1), en particulier un disque intervertébral artificiel, présentant un axe central (2), une partie supérieure (10) destinée à être placée contre la plaque de base d'un corps vertébral situé au-dessus, ainsi qu'une partie inférieure (20) destinée à être placée contre la plaque supérieure d'un corps vertébral situé au-dessous. La partie supérieure (10) présente un bord ventral (11), un bord dorsal (12), deux bords latéraux (13, 14), une face d'apposition supérieure (15) et une surface inférieure (16) et la partie inférieure (20) présente un bord ventral (21), un bord dorsal (22), deux bords latéraux (23, 24), une face d'apposition inférieure (25) et une surface supérieure (26). Les parties supérieure et inférieure (10, 20) peuvent être déplacées l'une par rapport à l'autre au moyen de deux articulations (38 ; 39) disposées entre lesdites parties. Chacune de ces articulations (38 ; 39) présente un axe de rotation (3 ; 4), les deux axes de rotation (3 ; 4) étant perpendiculaires l'un par rapport à l'autre. Les deux articulations (38 ; 39) sont réalisées au moyen de trois pièces d'articulation supérieure, centrale et inférieure (31 ; 32 ; 33). L'invention se caractérise en ce que chaque articulation (38 ; 39) comprend une première pièce d'articulation (31 ; 32 ; 33) pourvue d'une partie saillante (49 ; 50) présentant une arête (51 ; 53), une deuxième pièce d'articulation (31 ; 32 ; 33) pouvant être montée sur ladite partie saillante (49 ; 50) de façon basculante autour de l'axe de rotation (3 ; 4).
Patent CA-2510402-A1 (CA)
Inventor: ALLEN JEFFREY PETER
IPC: H01M8/24
Filed: 2004-01-12
Abstract: A fuel cell end plate configured to transmit substantially constant compressive forces along a surface of a fuel cell is provided. The fuel cell end plate is configured such that the compressive force is substantially constant along the surface of the fuel cell even when the surface of the fuel cell is non-parallel. The fuel cell end plate is also configured such that the surfaces of the end plate remain substantially parallel when the fuel cell end plate is in contact with a non-parallel surface of a fuel cell or fuel cell stack. The fuel cell end plate is also configured to act as a distribution manifold for the distribution of reactants and coolants to the fuel cell stack. Fuel cell assemblies including the fuel cell end plate and methods of assembling the fuel cell end plate are also disclosed.
Patent CA-2513557-A1 (CA)
Inventor: GANDON-PAIN SYLVIE
IPC: C10G49/02
Filed: 2004-01-19
Abstract: Method for producing a purified C5 fraction (A), enriched in isoprene (I) and suitable for selective catalytic polymerization of (I), starting from an initial C5 fraction (B) from a fluidized-bed catalytic cracker.  Method for producing a purified C5 fraction (A), enriched in isoprene (I) and suitable for selective catalytic polymerization of (I), starting from an initial C5 fraction (B) from a fluidized-bed catalytic cracker. The method comprises subjecting an intermediate C5 fraction (C), containing less than 30 wt.% methylbutenes (II) and derived from (B), to a dehydrogenation reaction, and purifying the product to produce (A), practically free of disubstituted alkynes, 'real' alkynes and cyclopentadiene. The catalyst for polymerization of (I) comprises a conjugated diene; a rare earth metal salt (X) of an organophosphoric acid, suspended in an inert, saturated hydrocarbon solvent; an alkylating agent (Y; trialkylaluminum or dialkylaluminum hydride) with mole ratio (Y):(X) 1-5; and an alkylaluminum halide (Z) as halogen donor.  An Independent claim is also included for a method for producing an isoprene homopolymer (HP) with content of cis-1,4 chains at least 98%, by using the specified catalyst system.
Patent CA-2516343-A1 (CA)
Title: Dual-chamber type prefilled syringe
Inventor: AKAGI YASABURO
IPC: A61M5/28
Filed: 2004-02-18
Abstract: A two chamber-type pre-filled syringe where a first chamber and a second chamber are formed by sealingly installing in a tube body a front plug body, a middle plug body, and an end plug body. A bypass (14) is formed in the inner face of a tube body (2). A first chamber (9) and a second chamber (10) are first communicated with each other through the bypass (14) when a middle plug body (7) moves to the position where the bypass (14) is formed. In a state at this position, or a liquid-movement start state (S), the volume (VS) in the tube body between a fore end (2a) of the tube body (2) and a rear end (6b) of a front plug body (6) is set to be 60% or more of the volume (VC) of a second received-component (12). This prevents, when a liquid-like received-component in the second chamber flows into the first chamber, a portion of the liquid-like received-component from passing through the first chamber and reaching a needle installation portion at the tip of the tube body.
Patent CA-2516622-A1 (CA)
Inventor: HEHL KARL
IPC: B29C45/10
Filed: 2004-02-19
Abstract: Disclosed is a mold-closing device for an injection molding machine used for processing plastic materials, in which the mold supports accommodating an injection mold therebetween and a support element (13) for a mold-closing mechanism (C) are mounted on the machine base (14). In order to be able to precisely align the mold supports, the first mold support is also mounted on the machine base (14) so as to be movable in the closing direction, the support element (13) is mounted on the machine base (14) or a part thereof via a stationary bearing, and a positioning mechanism (16) is provided for adjusting the angle between the support element (13) and the machine base (14).
Patent CA-2517151-A1 (CA)
Inventor: MARTIN ANDREW LOUIS
IPC: G01S15/58
Filed: 2004-02-26
Abstract: A method and system for acoustically sounding the lower atmosphere involves the transmitting of an acoustic chirp and the processing of returned echoes and interference using wavelet and matched filter techniques. A single transmitter and four receivers may be used, with receivers located equidistant from the transmitter on the cardinal points of the compass. N, S, E, & W  inputs are digitized and input to a wavelet filter (50) together with the transmitter chirp signal (R or D) for the attenuation of the direct signal and ambient noise signals. The interference-attenuated signals are then processed in a matched filter (52) to extract phase and amplitude outputs (54 and 56), the phase output being unwrapped (70). The N and S phase signals and the E and W phase signals are then separately differenced (74 and 80) and the results used to compute (86 and 92) wind speed and bearing. Extracted amplitude signals (56) are put through a second wavelet filter (58) to remove echo clutter before being stored, along with the wind speed and bearing data in a range gate (96).
Patent CA-2517839-A1 (CA)
Inventor: BACHMANN MARTIN F
IPC: C07K14/025
Filed: 2004-03-25
Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G  (CpGs), and particular peptides derived from MelanA linked thereto. Such CpG~VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA  peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
Patent CA-2519184-A1 (CA)
Title: Methode pour former rapidement un modele stochastique representatif de la distribution d`une grandeur physique dans un milieu heterogene par une selection appropriee de realisations geostatistiques
Inventor: MEZGHANI MOKHLES
IPC: G06F17/17
Filed: 2004-03-16
Abstract: Méthode pour former rapidement un modèle stochastique représentatif de la distribution d'une grandeur physique dans un milieu hétérogène poreux qui so it calé par rapport à des données dynamiques, par une sélection appropriée de réalisations géostatistiques à combiner linéairement. On utilise un processu s itératif de déformation graduelle où l'on combine linéairement à chaque itération, une réalisation géostatistique initiale (y) du milieu, et un nomb re (N-1) (N>1) autres réalisations (zi) i =1,~, (N-1), indépendantes de la réalisation initiale (y), en imposant des contraintes aux coefficients de combinaison linéaire des réalisations (y) et (zi) i =1,~, (N-1), et l'on minimise une fonction objectif (J) mesurant l'écart entre un jeu de données simulées déduites de la dite combinaison au moyen d'un simulateur, et les dites données dynamiques. Pour minimiser rapidement la fonction objectif, on calcule le multiplicateur de Lagrange (.lambda.), .lambda. .isin. RN-1 assoc ié à la contrainte portant sur les valeurs spécifiées des coefficients des réalisations (zi) i =1,..., (N -1) . La valeur absolue .lambda.i de la i-ièm e composante du multiplicateur .lambda. indique la sensibilité de la fonction objectif par rapport à la i-ième réalisation géostatistique (zi).
Patent CA-2520828-A1 (CA)
Inventor: MARTENYI FERENC
IPC: A61K/
Filed: 2004-04-01
Abstract: The present invention relates to a method for the treatment, including the maintenance treatment, of affective disorders, which comprises administering, especially every 20 to 28 hours, to said subject a therapeutically effective amount, especially an amount between about 500 and about 3000 mg, of a compound of formula (I) wherein R1 represents hydrogen or C1-C3alkyl carbonyl;  to the use of a compound of (I) or a pharmaceutically acceptable salt thereof for the manufacture of a pharmaceutical composition for the treatment of affective disorders; to a combination comprising: (a) a compound of formula (I); and (b) at least one compound selected from the group consisting of lithium, divalproex, conventional antipsychotics, atypical antipsychotics, lamotrigine and antidepressants; and to the use of such combination for the treatment of affective disorders.