Patent SG-11201408700U-A (SG)
Title: Cyanoguanidines and their use as antiviral agents
Inventor: GOMTSIAN ARTOUR
IPC: C07D417/04
Filed: 2013-06-28
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/005129 A1 (51) International Patent Classification: C07D 401/14 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 417/04 (2006.01) C07D 241/26 (2006.01) C07D 241/44 (2006.01) C07D 471/04 (2006.01) A61K31/4995 (2006.01) A61K 31/517 (2006.01) A61K31/4985 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/048789 28 June 2013 (28.06.2013) English English (30) Priority Data: 61/665,797 28 June 2012 (28.06.2012) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, Illinois 60064 (US). (72) Inventors: GOMTSIAN, Artour; 104 Adair Court, Ver- nont Hills, IL 60064 (US). DEKHTYAR, Tatyana; 1220 Briarwood Lane, Libertyville, IL 60064 (US). FRANK, Kristine E.; 364 Gatewood Lane, Grayslake, IL 60064 (US). FRIEDMAN, Michael M.; 34 Garrison Road, Apt. 2, Brookline, MA 02445 (US). JOSEPHSOHN, Nathan; 217 West Springfield, #4, Boston, MA 02118 (US). MOLLA, M-Akhteruzz; 1249 Vista Drive, Gurnee, IL 60031 (US). VASUDEVAN, Anil; 105 13th Avenue, Un­ ion grove, WI 53182 (US). NG, Teresa; 3229 N. Walker E„ Arlington Heights, IL 60004 (US). SHAFEEV, Mikhail; 9-Gogoliya St., Apt 73, Khimki, Moseow region, 141401 (RU). (74) Agents: DAVIS, Bradley E. et al.; AbbVie Inc. 1 North Waukegan Road, AP34-2/V377, North Chicago, Illinois 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 0\ CJ i-H © o o CJ (54) Title: CYANOGUANIDINES AND THEIR USE AS ANTIVIRAL AGENTS (57) Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.