baber/WOPTO huggingface dataset:
Patent CA-2464199-A1 (CA)
Inventor: SCHWARTZ ROBERT J
IPC: C07K14/60
Filed: 2002-10-25
Abstract: The present invention pertains to a method for decreasing the body fat proportion, increasing lean body mass ("LBM"), increasing bone density, or improving the rate of bone healing, or all, of a subject. Overall, the embodiments of the invention can be accomplished by delivering a heterologous nucleic acid sequence encoding GHRH or functional biological equivalent thereof into the cells of the subject and allowing expression of the encoded gene to occur while the modified cells are within the subject. For instance, when such a nucleic acid sequence is delivered into the specific cells of the subject tissue specific constitutive expression is achieved. Furthermore, external regulation of the GHRH or functional biological equivalent thereof gene can be accomplished by utilizing inducible promoters that are regulated by molecular switch molecules, which are given to the subject. The preferred method to deliver the constitutive or inducible nucleic acid encoding sequences of GHRH or the functional biological equivalents thereof is directly into the cells of the subject by the process of in vivo electroporation. A  decrease the body fat proportion and an increase in lean body mass ("LBM"), or both of a subject is achieved by the delivery of GHRH or functional biological equivalent thereof as described herein by into the subject as recombinant proteins. In addition, an increase in bone density and improvement in the rate of bone healing is also achieved.
Patent CA-2465400-A1 (CA)
Title: Percussion device with a control valve for two alternately striking pistons
Inventor: RANTALA ESA
IPC: B25D9/18
Filed: 2002-11-07
Abstract: The invention relates to a percussion device comprising two percussion pistons alternately making a percussion motion and a control valve for controlling the percussion pistons The control valve comprises a slide affected by a force so that the slide is generally in a first position, but moves at the end of the percussion motion of the first percussion piston from the first position to a second position and correspondingly back to the first position at the end of the percussion motion of the second percussion piston.
Patent CA-2466998-A1 (CA)
Inventor: WARD KEVIN L
IPC: A61K9/22
Filed: 2002-11-12
Abstract: L'invention concerne une nouvelle série de polymères préparés par mélange de polymères ou de copolymères biodégradables, biocompatibles hydrophobes, tels que le poly(lactide-co-glycolide), et un copolymère biocompatible, amphipathique ayant un taux d'absorption d'eau d'environ 2 ou moins. L'invention concerne également un procédé de préparation desdits mélanges de polymères et de compositions à libération retardée comprenant les nouveaux mélanges de polymères. En outre, les compositions à libération retardée peuvent être utilisées pour délivrer à un patient, en cas de besoin, un produit biologiquement actif ayant un profil de libération désirable, avec action retardée.
Patent CA-2468710-A1 (CA)
Title: Chromosomal saturation mutagenesis
Inventor: CAYOUETTE MICHELLE
IPC: C12Q1/68
Filed: 2002-12-03
Abstract: In One aspect, the invention provides methods for Chromosomal Saturation Mutagenesis (CSM) comprising generating randomly mutated, overlapping segments for an entire chromosome using error-prone PCR or other techniques, and libraries of nucleic acids made by these methods.
Patent CA-2472483-A1 (CA)
Title: Stapler with bending arms which cut the staple legs against a pad
Inventor: JOHANSSON PETER
IPC: B25C5/02
Filed: 2002-12-04
Abstract: A stapler comprising a base, an operating arm constructed and disposed for engagement with a user's hand to produce manual operational movement of the operating arm relative to the base, a stapling unit constructed to drive a staple into a workpiece; and a bending and cutting mechanism comprising bending arms and a cutting pad, the bending arms and the cutting pad configured to bend legs of the staple against the workpiece and engage to cut off an excess length of the legs when the staple is driven into the workpiece, wherein the stapling unit is coupled to the operating arm to drive the staple into the workpiece in response to manual operational movement of the operating arm, and wherein the bending and cutting mechanism is coupled to the manual operational movement of the operating arm to bend the legs of the driven staple and to cut off excess length of the legs of the driven staple.
Patent CA-2472614-A1 (CA)
Inventor: ROCHEFORT OSCAR
IPC: B65D5/74
Filed: 2003-01-09
Abstract: A dispensing container (10, 110) for fluent material, which container is intended to be hung vertically from a support, such as a hook, is provided.  The dispensing container has a tubular body, with a bottom dispensing region that is configured to promote the collection of the fluent material and guidance of the fluent material toward the inlet aperture of a dispensing nozzle (50) that is received in the side (30, 130) of the bottom dispensing region. The dispensing container (10, 110) is preferably fabricated from corrugated paperboard or similar material, and is preferably configured to serve as the shipping container for the fluent material as well, so as to reduce or eliminate the need for a further outer shipping container. The fluent material may be contained within a separate liner structure, within the surrounding tubular body, in a ""bag-in-box" type of container arrangement.
Patent CA-2474028-A1 (CA)
Title: Riser control device with vertical actuator
Inventor: EDWARDS JEFFREY CHARLES
IPC: E21B33/064
Filed: 2003-01-15
Abstract: Riser control device, particularly designed to be used in connection with spool or horizontal production trees (12) for wells in sub-sea oil and gas installations. Within a housing (1, 2) of the device is provided, in opposed direction, radially movable pair of rams (6) for isolating (sealing off) the well and simultaniously, in opposed direction radially movable pair of shear blades (7) for cutting off an intervention string or the like. The rams (6) and blades (7) are driven by means of a within the housing (1, 2) vertically provided actuator (8, 9, 23). The actuator may be in the form of a hydralically driven annulor piston (23) / annular chamber (29, 30) device, which via piston rods (14) and translation beams (8) transforms the movement of the piston (23) to open or close the rams (6) and shear blades (7).
Patent CA-2475736-A1 (CA)
Title: Vibrio cholerae lps detoxified derivatives and immunogenic compositions containing them
Inventor: GRANDJEAN CYRILLE
IPC: C07K16/12
Filed: 2004-07-23
Abstract: The presence of a free amino group on the D-glucosamine residue of the detoxified lipopolysaccharide (LPS) of Vibrio cholerae is exploited for the site-specific derivatization of this polysaccharide. The invention allows the preparation of V. cholerae LPS derivatives useful for the immuno-detection. The invention also provides a convenient way to prepare detoxified LPS of V. cholerae (and especially V. cholerae O1, serotype Inaba)-immunogenic carrier conjugates. Thanks to the single modification introduced following the adopted strategy, all derivatives of the detoxified LPS can be fully analyzed in term of purity and identity. This leads to an improved characterization of the conjugates and a better control of their preparation processes.
Patent CA-2476187-A1 (CA)
Title: Method for manufacturing fuel cell separator plates under low shear strain
Inventor: CHOPRA DIVYA
IPC: H01B1/24
Filed: 2003-02-13
Abstract: An improved process for fabricating an electrically conductive shaped articl e is disclosed. The process includes one or more process stages selected from the group consisting of: preparing one or more feeds of the plastic and fillers; feeding the plastic and fillers to a melt compounding stage wherein a homogeneous melt of the composition is obtained; transferring the homogeneou s melt ; and subjecting the homogeneous melt to a moulding process to produce the conductive shaped article. One or more of the process stages is conducte d under low shear strain conditions so that the article has a through-plane resistivity of less than about 600 ÁOhm-m. Also disclosed are the conductive plates having improved performance properties such as flexural strength, conductivity and surface smoothness.
Patent CA-2477904-A1 (CA)
Title: Accoustical apparatus and method for measuring water level in a ground water well
Inventor: CARKNER STEVE
IPC: E21B47/04
Filed: 2004-08-16
Abstract: An acoustic distance measuring device adapted to measure the level of water in a ground water well by first emitting a sonic low frequency acoustic pulse and measuring the time-of-flight for each reflected pulse from the surface of the water in the well. Each reflected pulse must have an amplitude greater than a threshold amplitude or it will be rejected. Based on time-of-flight measurements from the first low frequency sonic pulse reception windows are established for a second higher frequency sonic pulse. To refine the time-of-flight measurements for the second pulse only those reflected pulses whose reception times fall within the reception windows are accepted. A more accurate calculation of the distance from the sonic pulse emitter to the surface of the water is accomplished by using the refined time-of-flight measurements from the second higher frequency pulse.
Patent CA-2478686-A1 (CA)
Inventor: ASHBURN WILLIAM L
IPC: G01T1/00
Filed: 2003-03-06
Abstract: A laser localizer may include a laser pointer on handle to be placed co-parallel against the surface of a detector head of a gamma camera and a mirror angled to direct the laser beam normal with respect to the detector head surface. The source of radiation may be a button containing Co-57 or other radioactive material placed under the mirror. When the image of the radioactive material in the laser localizer is superimposed on an image of a source of radioactive uptake in the patient on a system monitor, the laser beam will automatically point to the source within the body.
Patent CA-2479666-A1 (CA)
Title: (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
Inventor: MAN HON-WAH
IPC: A61P17/06
Filed: 2003-03-20
Abstract: Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discused. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4.
Patent CA-2479703-A1 (CA)
Title: Fuels compositions and methods for using same
Inventor: COLUCCI WILLIAM J
IPC: C10L1/224
Filed: 2004-08-31
Abstract: A fuel composition and methods for using it for controlling deposit formation in a spark-ignition internal combustion engine, such as a direct injection engine, comprising a spark-ignition fuel, a detergent, and a deposit inhibitor compound.
Patent CA-2485717-A1 (CA)
Inventor: SITTI METIN
IPC: C09J7/00
Filed: 2003-05-13
Abstract: A fabricated microstructure (10) comprising at least one protrusion (18) capable of providing an adhesive force at a surface of between about 60 and 2000 nano-Newtons. A stalk (12) supports the protrusion (18) at an oblique angle relative to a supporting surface. The microstructure can adhere to different surfaces.
Patent CA-2487424-A1 (CA)
Inventor: FOKIN VALERY
IPC: C07D249/06
Filed: 2003-05-30
Abstract: A metal catalyzed click chemistry ligation process is employed to bind azide s and terminal acetylenes to give triazoles. In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give on ly 1,4-disubstituted ~1,2,3~-triazoles.
Patent CA-2488554-A1 (CA)
Title: Air-bubble-monitoring medication assembly, medical system and method
Inventor: KATZ HAL H
IPC: A61M5/00
Filed: 2004-11-26
Abstract: An air-bubble-monitoring medication assembly includes a drug infusion subassembly having a tube for administering therein a liquid to a patient, a bubble-size determinator which is positioned to sense an air bubble entrained in the liquid in the tube and which determines the volume of the air bubble, and an analyzer. The analyzer logs the time the detector senses an air bubble and the volume of the air bubble, calculates a running sum of a total air volume of all air bubbles sensed over a time interval, compares the running sum with a preselected limit, and generates an output when the running sum exceeds the preselected limit. The medical system additionally includes a controller assembly which determines a delivery schedule for administering the liquid and which controls the drug infusion subassembly to administer the liquid in accordance with the determined delivery schedule. The method performs the analyzer functions.
Patent CA-2490614-A1 (CA)
Inventor: MONTEYNE DONALD
IPC: H04N7/16
Filed: 2004-12-22
Abstract: A system and method for creating, scheduling, and managing time slots for installation appointments. Embodiments of the present invention permit a trading partner to over a customer the ability to schedule installation of cable services on-line. A cable operator maintains an inventory of time slots, One or more time slots from the time slot inventor are offered to a customer based on ordering information received from the customer. A customer selects a time slot from the one or more offered time slots. A cable operator then assigns an installation appointment to the customer within the time slot selected by the customer. A cable operator may also determine the status of the inventory of time slots (e.g., time slots allocated, time slots consumed, and time slots available) for a system, a location, or a trading partner.
Patent CA-2491437-A1 (CA)
Inventor: LOISY JEAN
IPC: F02C3/113
Filed: 2005-01-05
Abstract: The invention relates to a turbine engine (1) with a semi-fixed turbine, particularly for aircraft driving a receiver (2) controlled so as to preserve a roughly constant rotation speed. The turbine engine, in particular via a gear system (20), drives the receiver and an LP compressor (6) with an LP turbine (14). According to the invention, the gear system has a torque control system (26) maintaining a constant ratio between the drive torque of the receiver transmitted by the gear system and the drive torque of the LP compressor transmitted by this same gear system.
Patent CA-2491854-A1 (CA)
Title: A fluid actuator
Inventor: NEWTON STEVEN R
IPC: F16D65/28
Filed: 2005-01-07
Abstract: An actuator responsive to fluid signals to retract and extend a piston. The actuator includes a cylinder and a pressure piston carried inside the cylinder. Also included is a shaft, and a rod connected to the pressure piston. The actuator further includes a first port for receiving a fluid pressure to move the pressure piston to a first position. The actuator also has a locking mechanism. The locking mechanism has a first and second surface, and both surfaces are movable in response to the fluid pressure at the first port. The surfaces lock the pressure piston in a first position upon removal of the fluid pressure at the first port.
Patent CA-2492409-A1 (CA)
Title: Head restraint guide system
Inventor: RUNDE DAVID M
IPC: B60N2/48
Filed: 2005-01-13
Abstract: A head restraint guide system is provided to reduce or eliminate contact points between an armature of a head restraint and a housing in a vehicle seat assembly. The housing extends through a seat back frame. In a first embodiment, a retainer is secured to the housing and a washer is seated within the retainer. A retaining cap closes and maintains the washer within the retainer. The armature extends through the guide system contacting only the washer, thus eliminating vibrations and noise due to contact between the armature and the attachment tube. The washer comprises a non-rigid material, preferably felt.  In a second embodiment, an elongated sleeve comprising a non-rigid material, preferably felt, is seated within the housing. The sleeve receives and surrounds the armature to eliminate contact points between the armature and the housing, thereby eliminating vibrations and noise therebetween.
Patent CA-2495179-A1 (CA)
Title: Compounds having an activity at metabotropic glutamate receptors
Inventor: ARORA JALAJ
IPC: A61P25/00
Filed: 2003-08-08
Abstract: The present invention relates to new compounds of formula I, wherein P Q X1 X2 X3 X4 X5 R R1 R2 R3 R4R5 G M1 M2 M3 m and n are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
Patent CA-2495880-A1 (CA)
Inventor: EATHERTON ANDREW JOHN
IPC: C07D401/06
Filed: 2003-08-19
Abstract: This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
Patent CA-2496696-A1 (CA)
Inventor: HAENGGI PETER
IPC: C10M133/50
Filed: 2003-09-11
Abstract: L'invention concerne des compositions améliorées à base de lubrifiants contenant des semi-amides d'acide succinique et l'utilisation de ces compositions lubrifiantes dans l'amélioration des propriétés d'utilisation de lubrifiants, tels que des fluides hydrauliques ou de travail de métaux, des graisses, des huiles pour engrenages ou des huiles pour moteurs.
Patent CA-2497395-A1 (CA)
Inventor: UENO TAKASHI
IPC: H01L23/498
Filed: 2003-09-03
Abstract: L'invention concerne une pièce électronique, un équipement électronique, un alliage métallique destiné à être utilisé dans ces pièces, un procédé destiné au façonnage d'un matériau électronique ou métallique, ainsi qu'une pièce optoélectronique. Par exemple, un alliage métallique destiné à des pièces électroniques pouvant être utilisées dans des écran à cristaux liquides, divers produits ou pièces à semi-conducteurs, des cartes imprimées et d'autres matériaux tels que des composants de microcircuits intégrés. Cet alliage possède une résistivité inférieure à celle des articles classiques, présente un avantage dans le processus de fabrication, est sûr et a une excellente aptitude au façonnage. L'invention concerne également une pièce électronique et un équipement électronique fabriqués à partir dudit alliage métallique. Un alliage comprend principalement du Cu et entre 0,1 et 3,0 % en masse de Mo et un total compris entre 0,1 et 3,0 % en masse d'un ou plusieurs éléments sélectionnés dans le groupe comprenant Al, Au, Ag, Ti, Ni, Co et Si utilisés comme matériau métallique. Dans ce matériau métallique, le Mo est ajouté au Cu pour obtenir un mélange homogène au niveau du joint de grain du Mo dans le Cu, ce qui augmente la résistance aux intempéries de l'ensemble du corps du Cu.
Patent CA-2498325-A1 (CA)
Inventor: DIENER JOHN L
IPC: C12Q1/68
Filed: 2003-09-17
Abstract: Cette invention concerne des substances et des méthodes pour le traitement prophylactique du VIH. Sont décrites des compositions thérapeutiques, dont des compositions thérapeutiques régulées par des aptamères à spécificité pour des composants de la maladie transmise par le VIH ainsi que des méthodes d'administration de ces compositions thérapeutiques sous forme de vaccins contre l'infection par le VIH.
Patent CA-2499581-A1 (CA)
Title: Critical phase alkylation process
Inventor: BUTLER JAMES R
IPC: C07C6/12
Filed: 2003-09-25
Abstract: A process for the production of ethylbenzene by the ethylation of benzene in the critical phase over a molecular sieve aromatic alkylation catalyst comprising cerium-promoted zeolite beta. An aromatic feedstock having a benzene content of at least 90 wt.% is supplied into a reaction zone and int o contact with the cerium-promoted zeolite beta having a silica/alumina mole ratio within the range of 50-150 and a cerium-aluminum ratio of 0.5-1.5. Ethylene is supplied to the alkylation reaction zone in an amount to provide a benzene/ethylene mole ratio of 1-15. The reaction zone is operated at temperature and pressure conditions in which benzene is in the super critica l phase to cause ethylation of the benzene in the presence of the cerium zeoli te beta alkylation catalyst. An alkylation product is produced containing ethylbenzene as a primary product with the attendant production of heavier alkylated by-products of no more than 60 wt.% of the ethylbenzene. The critical phase alkylation reaction may be followed by the transalkylation of a polyalkylated aromatic component.
Patent CA-2501077-A1 (CA)
Inventor: MAIRA-LITRAN TOMAS
IPC: A61K39/085
Filed: 2003-11-12
Abstract: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo.The invention also relates to the use of dPNAG  as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.
Patent CA-2502642-A1 (CA)
Inventor: BELANGER GERMAIN
IPC: A63B59/70
Filed: 2005-03-29
Abstract: The invention relates to hockey stick shafts having properties varying along a length thereof and to a method for fabrication thereof, by providing at least one of longitudinally oriented high tensile strength wires and fibers on at least one part of at least one plane surface thereof.
Patent CA-2503813-A1 (CA)
Title: Tool holder and metal cutting insert with chip breaking surfaces
Inventor: SIMPSON VANDELL III
IPC: B23B27/04
Filed: 2003-10-17
Abstract: A metal cutting insert (10) having a pair of cutting portions (10a, 10b) disposed on either end of a shank portion (10c), each cutting portion having a front clearance face (20), the upper boundary of which defines a cutting edge (14). A pair of spaced apart chip breaking surfaces (26a, 26b, 28a, 28b) commence at or near the cutting edge and extend away from the cutting edge. A pair of secondary chip breaking surfaces (44a, 44b, 46a, 46b, 48a, 48b, 50a, 50b) are located downstream of the first chip breaking surfaces and are interconnected with associated first chip breaking surfaces by transition surfaces. A center channel (30) is located between the chip breaking surfaces and includes an entry portion (30a). A tool holder (100) includes a base (102) and clamping arm (104) which together define a gap (106) for receiving one of the cutting portions of the insert.
Patent CA-2504554-A1 (CA)
Inventor: CROOKE STANELY T
IPC: C12Q1/68
Filed: 2003-11-04
Abstract: Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at leas t a portion of the second oligomer, at least a portion of the first oligomer i s complementary to and capable of hybridizing to a selected target nucleic aci d, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2' substituent group on a sugar moiety that is not H or OH. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.