baber/WOPTO huggingface dataset:
Patent CA-3062770-A1 (CA)
Title: Use of a cyp3a4 substrate drug with a cyp3a4 substrate inhibitor
Inventor: SRINIVASAN SUNDAR
IPC: A61K31/496
Filed: 2017-05-16
Abstract: The present disclosure provides for methods of treating a patient with a CYP3A4 substrate drug contraindicated for concomitant administration with a strong CYP3A4 inhibitor, wherein the patient is treated with multiple doses of posaconazole, stops posaconazole treatment, and then is treated with the CYP3A4 substrate drug. In some embodiments, treatment with the CYP3A4 substrate drug is delayed for about 2-21 after stopping posaconazole. In some embodiments, the patient is treated with or prescribed a reduced dose of the CYP3A4 substrate drug for about 2-21 after stopping posaconazole.
Patent CA-3064715-A1 (CA)
Inventor: COTE RIC
IPC: A61B17/12
Filed: 2018-05-01
Abstract: L'invention concerne un système attaché pour un traitement cryogénique dans lequel une pièce à main ayant une sonde allongée ayant une pointe distale et une longueur flexible, au moins une lumière de perfusion positionnée à travers la sonde allongée ou le long de celle-ci, et une doublure, peut être attachée à une station de base ayant un réservoir d'un fluide de cryoablation par l'intermédiaire d'une connexion ayant un corps flexible allongé. La connexion définit au moins une lumière de fluide pour l'administration du fluide de cryoablation depuis le réservoir et vers la lumière de perfusion à l'intérieur de la pièce à main.
Patent CA-3068617-A1 (CA)
Title: Fiber optic connectors and connectorization employing adhesive admitting adapters
Inventor: ROSSON JOEL CHRISTOPHER
IPC: G02B6/38
Filed: 2018-06-22
Abstract: Fiber optic connectors, connector housings, connectorized cable assemblies, and methods for the connectorization of cable assemblies are provided with particular cable adapter features, adapter extensions, multi-diametrical sealing flexures, subcutaneous sealing elements, and combinations thereof, for improved connector and cable performance, integrity, and durability.
Patent CA-3069651-A1 (CA)
Title: Steel sheet for crown cap, crown cap and method for producing steel sheet for crown cap
Inventor: UENO TAKASHI
IPC: C21D9/46
Filed: 2018-07-25
Abstract: A steel sheet for crown cap having excellent formability from which a crown cap having an excellent pressure resistance can be produced without an expensive soft liner even if the steel sheet is subjected to sheet metal thinning, the steel sheet having: a chemical composition containing, in mass%, C: more than 0.006 % and 0.012 % or less, Si: 0.02 % or less, Mn: 0.10 % or more and 0.60 % or less, P: 0.020 % or less, S: 0.020 % or less, Al: 0.01 % or more and 0.07 % or less, and N: 0.0080 % or more and 0.0200 % or less, with the balance being Fe and inevitable impurities; and a percentage of a region of more than 0 % and less than 20 % at a position of 1/2 of a sheet thickness, the region having a dislocation density of 1 x 10 14 m -2 or less.
Patent CA-3070262-A1 (CA)
Title: Procede de fabrication d'une preparation pharmaceutique
Inventor: CHAVEZ ELIZABETH SERRANO
IPC: C07K7/16
Filed: 2018-08-10
Abstract: La présente invention concerne des formes cristallines de carbétocine, un procédé pour leur fabrication et des préparations pharmaceutiques de celles-ci.
Patent CA-3071650-A1 (CA)
Inventor: OZINGA DAVID G
IPC: A61B17/3211
Filed: 2018-08-13
Abstract: L'invention concerne un outil chirurgical comprenant un boîtier (102) ayant un dispositif d'entraînement et une lame chirurgicale (106) configurée pour être tournée de manière bidirectionnelle par le conducteur. L'outil chirurgical comprend également une plaque d'appui (108) configurée pour recevoir la lame chirurgicale. La plaque d'appui comprend une partie inférieure (702) configurée pour reposer sur un tissu oculaire de l'oeil d'un patient. La partie inférieure comprend une fente (704, 706) configurée pour permettre le passage d'une partie de la lame chirurgicale à travers la partie inférieure de la plaque d'appui et dans le tissu oculaire de l'oeil du patient. La plaque d'appui comprend également de multiples parois (712, 714, 716) ayant de multiples ouvertures (718, 722). Les ouvertures sont configurées pour recevoir des parties supplémentaires de la lame chirurgicale de telle sorte que la lame chirurgicale peut tourner par rapport à la plaque d'appui. La plaque d'appui comprend en outre une ouverture supplémentaire (720) ou un côté ouvert configuré pour permettre la visualisation de la lame chirurgicale et de la fente pendant l'utilisation.
Patent CA-3073676-A1 (CA)
Title: Systems and methods for operating a data center based on a generated machine learning pipeline
Inventor: PARMENTIER LAURENT
IPC: G06N20/00
Filed: 2020-02-25
Abstract: A system and a method for operating a data center. The operating comprising executing predictive maintenance of the data center or network monitoring of the data center. The operating being based on a generated machine learning (ML) pipeline, the method comprising accessing data relating to operations of the data center, the data being suitable for evaluating respective performances of the plurality of ML pipelines. The method comprises generating the plurality of ML pipelines, selecting a sub-set of ML pipelines from the plurality of ML pipelines, evolving the sub-set of ML pipelines to generate evolved ML pipelines, selecting a sub-set of evolved ML pipelines from the evolved ML pipelines and iterating until determination is made that iterating is to be stopped. The method also involves operating, by an operation monitoring system of the data center, at least one of the ML pipelines from the sub-set of evolved ML  pipelines.
Patent CA-3074530-A1 (CA)
Inventor: Ramos Flavio de Barros
IPC: B65D6/02
Filed: 2020-03-05
Abstract: This invention describes an interchangeable dismountable hinged box (C) for storing core samples, particularly used in the field of the collection of mineral materials, deriving from geological exploration activities, for subsequent analysis. The invention reveals a box (C) comprising modular walls (2 and 3) that can be fitted interchangeably with a base (1), allowing for the hinging of these walls (2 and 3) between a parallel position and a position perpendicular to the base (1). The box (C) comprises at least one storage compartment (C1) for core samples (T) defined between two modular transversal walls (2) and two modular longitudinal walls (3), and may comprise additional storage compartments (C1), obtained by interlocking interchangeable partitions (4) with modular walls (2). The box (C) is adaptable as it meets the need for storing core samples (T) of varying diameters.
Patent CA-3076689-A1 (CA)
Inventor: VAHEDI HANI
IPC: H02M7/04
Filed: 2018-10-12
Abstract: A battery charger capable of receiving single-phase AC power and delivering both AC and DC power to an electric power storage battery in accordance to different embodiments disclosed herein. An AC input receives single phase power from an electrical entry, a switch is connected to the AC input further connecting it either to an AC output or to a power converter which responds to a charge voltage value and a desired charge current value to convert power to a variable DC voltage at a variable current not exceeding a desired charge current value for a DC load. The power converter has at least one high voltage capacitor for storing power at a voltage boosted above a peak voltage of the AC input.
Patent CA-3076928-A1 (CA)
Inventor: CORTEZ FELINO V
IPC: A61B17/04
Filed: 2018-10-22
Abstract: Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post- deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.
Patent CA-3078525-A1 (CA)
Title: Tissue products with variations in mechanical properties and methods of treatment
Inventor: DAUNCH WILLIAM A
IPC: A61F2/00
Filed: 2018-10-19
Abstract: Devices with improved biomechanical properties and methods for treating tissue are provided. The compositions may comprise a cellular tissue matrices specifically shaped and sized for facial and neck implantation and having variations in mechanical and/or biological properties. Also provided are methods for treating tissue using these devices.
Patent CA-3078640-A1 (CA)
Inventor: KRAUSE HANS JUERG
IPC: B06B1/06
Filed: 2019-04-03
Abstract: An ultrasonic system for treating a submerged surface of a target structure, the system including: an ultrasonic generator for generating electrical energy to drive first and second ultrasonic transducers, the electrical energy including at least two different frequencies including a first and second operation frequency; first ultrasonic transducers configured to be mounted as a first array to the target structure, and connectable to the ultrasonic generator and operable to generate a first ultrasound signal from the first operation frequency; and second ultrasonic transducers configured to be mounted as a second array to the target structure, and connectable to the ultrasonic generator and operable to generate a second ultrasound signal from the second operation frequency, wherein the first and second ultrasonic transducers are spaceable from one another to produce guided ultrasonic waveforms through the target structure including heterodyned frequencies from the first ultrasound signal and the second ultrasound signal.
Patent CA-3078899-A1 (CA)
Title: Method and system for the air conditioning of closed environments, in particular for vertical farms
Inventor: TRAVAGLINI LUCA
IPC: F24F11/00
Filed: 2018-10-19
Abstract: The present invention discloses a method for the air conditioning of closed environments (314), particularly for vertical farms, comprising the steps of: - conditioning the air by means of an air treatment unit (301); - distributing and taking the conditioned air into the closed environment (314) through a plurality of channels (303, 305, 306, 307, 308, 309) connected to said air treatment unit (301); - generating a flow of conditioned air exiting, through a plurality of openings (316), from a first vertical wall (317) and taken in, through a plurality of openings (316), from the opposite vertical wall (315) of the closed environment (314); - alternatively inverting the delivery direction of the conditioned air along a substantially parallel direction with respect to the floor of the closed environment (314) so as to hit the inside of the closed environment (314) alternatively from one direction and subsequently from the opposite direction of the two vertical walls (318a, 318b). The invention also discloses a system for implementing the described method.
Patent CA-3080634-A1 (CA)
Title: Agent prophylactique et/ou therapeutique contre la demence
Inventor: ONO HIROHISA
IPC: A61K33/00
Filed: 2018-05-14
Abstract: La présente invention concerne un agent prophylactique et/ou thérapeutique contre la démence. L'agent prophylactique et/ou thérapeutique contre la démence contient de l'hydrogène gazeux utilisé comme principe actif.
Patent CA-3081043-A1 (CA)
Inventor: ZHANG XIANG
IPC: G06F16/906
Filed: 2020-05-21
Abstract: A method and a system for training a machine learning algorithm (MLA) for object classification. The machine learning algorithm includes an embedding layer and a classification layer. A set of embedding indices representing a reference object is received. The set of embedding indices has been generated based on a byte representation of the reference object. A label associated with the reference object indicative of a reference class the objects belongs to is received. The MLA is iteratively trained to classify objects by embedding the set of embedding indices to obtain an input vector and by predicting an estimated class based on the input vector, and updating a parameter of at least one of the embedding layer and the updated embedding layer. The set of embedding indices is generated by parsing the byte representation to obtain byte n-grams and by applying a hash function on the byte n-grams.
Patent CA-3081375-A1 (CA)
Title: Single-domain antibodies and variants thereof against pd-l1
Inventor: ZHANG YAFENG
IPC: C12N5/10
Filed: 2018-11-13
Abstract: Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
Patent CA-3082878-A1 (CA)
Title: A method for treating damaged peripheral nerves using x-ray microbeam irradiation
Inventor: DILMANIAN F
IPC: A61N5/00
Filed: 2018-11-16
Abstract: A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least.05 mm, and optionally administering Schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.
Patent CA-3084263-A1 (CA)
Inventor: TRACEWELL CARA
IPC: C12P5/00
Filed: 2018-12-06
Abstract: La présente invention concerne la manipulation de cellules microbiennes pour la production par fermentation de (6E)-8-hydroxygéraniol et concerne de nouvelles cultures et cellules microbiennes manipulées, ainsi qu'un procédé de production de (6E)-8-hydroxygéraniol.
Patent CA-3084979-A1 (CA)
Inventor: JOHNSON AUSTIN
IPC: E21B33/12
Filed: 2018-12-11
Abstract: L'invention concerne un procédé de surveillance d'état de joint d'étanchéité, lequel procédé peut déterminer l'état du joint d'étanchéité annulaire, l'état d'un ou plusieurs éléments d'étanchéité, entreprendre des actions pour assurer l'entretien du joint d'étanchéité annulaire pendant qu'un ou plusieurs éléments d'étanchéité passent d'un état neuf à un état usé, et fournir une notification à l'avance de la défaillance imminente d'un ou plusieurs éléments d'étanchéité de façon à éviter une défaillance catastrophique de joint annulaire pendant que la colonne montante marine est sous pression. Avantageusement, les opérations peuvent être effectuées de manière proactive plutôt que réactive, et un ou plusieurs éléments d'étanchéité peuvent être remplacés longtemps avant une défaillance, mais potentiellement plus tard qu'un calendrier de maintenance classique ne le prescrirait. Lesdits éléments d'étanchéité défaillants peuvent être remplacés de manière proactive sans dépressurisation de la colonne montante marine, avant une défaillance, ou un remplacement de joint d'étanchéité peut être planifié longtemps à l'avance et coordonné avec d'autres opérations d'appareil de forage afin d'améliorer l'efficacité et de garantir la sécurité de l'appareil de forage et du personnel.
Patent CA-3086944-A1 (CA)
Inventor: DAVIES MICHAEL
IPC: G01T1/00
Filed: 2019-02-08
Abstract: A system for surveying a surface (2) to measure a physical or chemical property associated with the surface. The system includes a handheld probe (4) measuring a physical or chemical property at locations over a surface (2). The video camera (12) captures video data of a user (6) using the handheld probe (4) to survey the surface. The depth sensing device (14) measures the distance to the handheld probe (4). Processing circuitry identifies the handheld probe from the video data and determines the position of the handheld probe (4) relative to the surface (2). A data recorder and/or a data transmitter records and/or transmits data representative of the physical or chemical property measured by the handheld probe (4) and data representative of the associated position of the handheld probe, when the handheld probe (4) is determined to be less than a threshold distance from the surface (2) being surveyed.
Patent CA-3087943-A1 (CA)
Inventor: WALLACE DEBRA JANE
IPC: C07D413/14
Filed: 2019-01-10
Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
Patent CA-3088199-A1 (CA)
Title: Subcutaneous dosing of anti-cd38 antibodies
Inventor: DAHL MARTIN
IPC: A61K39/395
Filed: 2019-01-14
Abstract: Methods of administering isolated anti-CD38 antibodies at low dosages subcutaneously are disclosed. The methods provide an effective treatment for autoimmune diseases and cancers, including hematologic diseases. Also disclosed are unit dosage forms for the anti-CD38 antibodies.
Patent CA-3088959-A1 (CA)
Inventor: BAKER DAVID
IPC: A61K31/137
Filed: 2018-02-06
Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.
Patent CA-3092439-A1 (CA)
Title: Ventilation control device and ventilation system
Inventor: KOBAYASHI KAZUYUKI
IPC: F24F11/77
Filed: 2019-03-11
Abstract: A ventilation control device (2) equipped with a total exhaust air volume reading unit (16), an exhaust device specification reading unit (17), an exhaust air volume allocation unit (18), and an exhaust air volume instruction unit (19). The total exhaust air volume reading unit (16) reads a total exhaust air volume that is set for a building. The exhaust device specification reading unit (17) reads the maximum exhaust air volume for each of a plurality of exhaust devices (3), as a specification for each of the exhaust devices (3). The exhaust air volume allocation unit (18) allocates the exhaust air volume read by the total exhaust air volume reading unit (16) in accordance with the maximum exhaust air volume for each exhaust device (3) as read by the exhaust device specification reading unit (17), thereby setting the exhaust air volume for each of the plurality of exhaust devices (3). The exhaust air volume instruction unit (19) provides an instruction to each of the plurality of exhaust devices (3) regarding the exhaust air volume that has been set by the exhaust air volume allocation unit (18).
Patent CA-3092599-A1 (CA)
Title: Seed inductor apparatus
Inventor: RIEDER JAMI
IPC: B65G53/06
Filed: 2018-09-05
Abstract: An inductor apparatus includes an inductor assembly mounted under a seed container such that seeds flow into a reservoir. An air conduit carrying pressurized air extends along the reservoir. Seed channels extend from an inlet located above a pickup air opening in the air conduit to an outlet, and a bypass channel extends downward from each seed channel through an upper wall of the air conduit. A pickup air stream flowing out the pickup air opening forms a seed air stream entrained with seeds flowing into each seed channel inlet and a bypass air stream flows from the air conduit through each bypass channel into each seed channel and the combined seed and bypass air streams flow out the seed channel outlets. The seed channel outlets can be arranged along each side of the inductor assembly, and the rate of flow of the bypass air stream can be adjusted.
Patent CA-3094891-A1 (CA)
Title: Preparations de cyclosporine destinees au traitement du syndrome de bronchiolite obliterante (sbo)
Inventor: DENK OLIVER
IPC: A61P11/00
Filed: 2019-04-09
Abstract: La présente invention concerne une composition comportant de la cyclosporine A (CsA), destinée à être utilisée dans la prévention du syndrome de bronchiolite oblitérante (SBO) chez le patient ayant bénéficié d'une double greffe pulmonaire, ou pour traiter le SBO ou pour prévenir ou retarder la progression du SBO chez un patient qui a bénéficié d'une double greffe pulmonaire et chez qui un SBO a été diagnostiqué, la composition étant administrée audit patient par inhalation de ladite composition sous forme d'aérosol comportant une dose thérapeutiquement efficace de cyclosporine A.
Patent CA-3097083-A1 (CA)
Inventor: CAMPBELL MEGHAN KERRISK
IPC: A61P25/00
Filed: 2019-05-14
Abstract: Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include inhibitors or antagonists of leukotriene A4 hydrolase ("LTA4H") with efficacy in treating and/or preventing aging-related conditions such as neurocognitive disorders.
Patent CA-3097385-A1 (CA)
Title: Ensemble de desaccouplement de differentiel
Inventor: SWINGER EVAN
IPC: B60K17/16
Filed: 2019-04-16
Abstract: L'invention concerne un différentiel amélioré pour un véhicule qui comprend un ensemble de désaccouplement en prise entre une couronne dentée et des engrenages à pignons et/ou un logement d'engrenage associé aux engrenages à pignons, l'ensemble de désaccouplement étant apte à désaccoupler une charge de couple de torsion entre la couronne dentée et les engrenages à pignons du différentiel. L'ensemble de désaccouplement accouple et désaccouple sélectivement la couronne dentée et les engrenages à pignons en se désaccouplant de préférence du logement d'engrenage disposé entre celles-ci. Le désaccouplement de la couronne dentée et des engrenages à pignons permet à la couronne dentée, au carter de différentiel, aux paliers et au reste de la boîte de transmission de s'arrêter de tourner tandis que les roues du véhicule tournent. Les engrenages à pignons du différentiel sont reliés mécaniquement au logement d'engrenage de sorte que le couple peut être transféré du logement d'engrenage du différentiel à l'engrenage à pignons du différentiel, puis aux engrenages latéraux du différentiel. Une bague cannelée est supportée à l'intérieur du carter de différentiel et définit une liaison mécanique qui verrouille la couronne dentée et le logement d'engrenage pour transférer un couple entre ceux-ci, la liaison mécanique pouvant être désaccouplée pour déverrouiller la couronne dentée et le logement d'engrenage et déconnecter une telle charge de torsion afin de permettre la rotation des engrenages latéraux et des engrenages à pignons indépendamment de la couronne dentée.
Patent CA-3098316-A1 (CA)
Inventor: HEIKENFELD JASON CHARLES
IPC: B01D61/38
Filed: 2019-05-03
Abstract: A sensing device for detecting a characteristic of an analyte in a sample solution and method of making the same is provided. The device includes one or more sensors configured to measure a characteristic of an analyte in a sample. The device further includes a sample solution that contains the analyte and one or more interfering solutes, wherein the interfering solute reduces a performance characteristic of the one or more sensors. The device further includes a sensor solution in fluidic communication with the one or more sensors. The device further includes a hydrophobic barrier that separates the sample solution from the one or more sensors, wherein the hydrophobic barrier is permeable to the analyte and impermeable to the interfering solute, and wherein the hydrophobic barrier is in fluidic communication with the sample solution and the sensor solution.