Patent SG-11201810837Q-A (SG)
Title: Biarylmethyl heterocycles
Inventor: PRIESTLEY ELDON
IPC: C07D417/14
Filed: 2017-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) WIPO I PCT oimitia °nolo olon Emu Imo oimIE (10) International Publication Number WO 2018/005591 Al (51) International Patent Classification: CO7D 401/14 (2006.01) CO7D 413/10 (2006.01) CO7D 405/14 (2006.01) CO7D 417/14 (2006.01) CO7D 413/14 (2006.01) CO7D 471/04 (2006.01) CO7D 233/90 (2006.01) CO7D 257/04 (2006.01) CO7D 401/10 (2006.01) CO7D 498/10 (2006.01) CO7D 235/26 (2006.01) A61K 31/437 (2006.01) C07D 403/10 (2006.01) A61P 9/00 (2006.01) C07D 403/14 (2006.01) (21) International Application Number: PCT/US2017/039646 (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: - with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 28 June 2017 (28.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/356,215 29 June 2016 (29.06.2016) US (71) Applicants: UNIVERSITE DE MONTREAL [CA/CA]; 2900 Edouard-Montpetit Boulevard, Montreal, Quebec H3T 1J4 (CA). BRISTOL-MYERS SQUIBB COMPA- NY [US/US]; P.O. Box 4000, Route 206 and Province Line Road, Princeton, NJ 08543-4000 (US). = (72) Inventors: PRIESTLEY, Eldon, Scott; 350 Carter Road, Hopewell, NJ 08540 (US). REZNIK, Samuel, Kaye; 15 Alton Ct. Apt. 3, Brookline, MA 02446 (US). RUEDIGER, Edward, H.; 2900 Edouard-Montpetit Boulevard, Montre- al, Quebec, H3T 1J4 (CA). GILLARD, James, R.; 2900 Edouard-Montpetit Boulevard, Montreal, Quebec, H3T 1J4 (CA). HALPERN, Oz, Scott; 350 Carter Road, Hopewell, NJ 08540 (US). JIANG, Wen; 350 Carter Road, Hopewell, NJ 08540 (US). RICHTER, Jeremy; 350 Carter Road, Hopewell, NJ 08540 (US). RUEL, Rejean; 2900 Edouard- Montpetit Boulevard, Montreal, Quebec, H3T 1J4 (CA). TRIPATHY, Sasmita; 2900 Edouard-Montpetit Boule- vard, Montreal, Quebec, H3T 1J4 (CA). YANG, Wu; 350 Carter Road, Hopewell, NJ 08540 (US). ZHANG, Xiaojun; 350 Carter Road, Hopewell, NJ 08540 (US). (74) Agent: KALYANARAMAN, Palaiyur, S. et al.; Hoff- mann & Baron, LLP, 6900 Jericho Turnpike, Syosset, NY 11791 (US). O O 00 O C (54) Title: BIARYLMETHYL HETEROCYCLES (57) : The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or [3-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments. (I)