Patent SG-11201809554V-A (SG)
Title: Methods of treating skin cancer by administering a pd-1 inhibitor
Inventor: LOWY ISRAEL
IPC: C07K16/28
Filed: 2017-05-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 November 2017 (16.11.2017) WIPO I PCT omit VIII Hot 0 Oil mom VIII 10110111110 oimIE (10) International Publication Number WO 2017/197263 Al (51) International Patent Classification: C07K 16/28 (2006.01) A61N 5/10 (2006.01) A61N 5/00 (2006.01) (21) International Application Number: PCT/US2017/032408 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 12 May 2017 (12.05.2017) with international search report (Art. 21(3)) (25) Filing Language: English with sequence listing part of description (Rule 5.2(a)) (26) Publication Language: English (30) Priority Data: 62/335,743 13 May 2016 (13.05.2016) US 62/340,142 23 May 2016 (23.05.2016) US 62/348,546 10 June 2016 (10.06.2016) US 62/350,305 15 June 2016 (15.06.2016) US 62/364,920 21 July 2016 (21.07.2016) US 62/374,020 12 August 2016 (12.08.2016) US 62/451,274 27 January 2017 (27.01.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (72) Inventors: LOWY, Israel; c/o Regeneron Pharmaceuti- cals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). SIMS, Tasha, N.; c/o Regeneron Pharmaceu- ticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). FURY, Matthew, G.; c/o Regeneron Pharma- ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (74) Agent: KOWALCHYK, Katherine, M.; Merchant & Gould P.C., P.O. Box 2903, Minneapolis, MN 55402-0903 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, N 1-1 (54) Title: METHODS OF TREATING SKIN CANCER BY ADMINISTERING A PD-1 INHIBITOR (57) : The present disclosure provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin O cancer). The methods of the present disclosure comprise administering to a subject in need thereof a therapeutically effective amount of \" a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous 0 cell carcinoma or basal cell carcinoma.