baber/WOPTO huggingface dataset:
Patent DE-69623597-T2 (DE)
Inventor: TOURNIER HERVE
IPC: C07C237/46
Filed: 1996-12-19
Granted: 2003-05-22
Abstract: The invention relates to non-ionic triiodo aromatic compounds and compositions comprising triiodo aromatic polymers useful for X-ray imaging of gastro-intestinal tract. Disclosed compounds are acrylic acid esters of triiodobenzenes with a different degree of reticulation and their polymers/homopolymers. A method of making the polymers, method of making X-ray contrast agents using the polymers and use of the contrast agents is also disclosed.
Patent DE-69624919-T2 (DE)
Inventor: SISK P
IPC: C07K1/22
Filed: 1996-06-03
Granted: 2003-09-04
Abstract: The extracellular domain, or fragment thereof, of a gonadotropin glycoprotein hormone receptor is expressed and secreted in a soluble and functionally hormone-binding form. A recombinant baculovirus transfer vector is constructed to include a gene segment encoding the extracellular domain, or fragment thereof, of the glycoprotein hormone receptor joined in frame with a gene segment encoding a baculovirus signal peptide and operably linked to a baculovirus promoter. Recombinant baculovirus generated by transfection or co-transfection of insect cells are then used to infect insect host cells for the expression and secretion of soluble receptor.
Patent DE-69633023-T2 (DE)
Inventor: OGDEN R
IPC: A62B18/08
Filed: 1996-12-06
Granted: 2005-01-05
Abstract: A facial mask assembly has a rigid shell (3), a flexible hose (12), and a swivel hose coupling (10) for connecting the rigid shell (3) to the flexible hose (12), the coupling (10) having first (14) and second (16) rigid sections. The first rigid section (14) is mounted to the rigid shell (3), for rotation relative to the rigid shell (3) about a first rotational axis (18). The second rigid section (16) is mounted to the flexible hose (12) for rotation relative to the flexible hose (12) about a second rotational axis (22). The coupling (10) further includes means for mounting the first (14) and second (16) rigid sections for rotation relative to each other about a third rotational axis (24). <IMAGE>
Patent DE-69700308-T2 (DE)
Inventor: STACK DOUGLAS RICHARD
IPC: A61K38/00
Filed: 1997-04-08
Granted: 1999-11-18
Abstract: The present invention is directed to certain glycopeptide dimers in which two glycopeptide units are covalently linked to one another through a modifiable amine on a saccharide. These dimers are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant-enterococci ("VRE").
Patent DE-69701753-T2 (DE)
Inventor: BERTELEAU GERARD
IPC: C01B13/02
Filed: 1997-01-23
Granted: 2001-02-22
Abstract: Ammonium nitrate (AN) stabilised by potassium nitrate (PN), contains (by weight) 1-7 % PN and 0.1-1% of an organic dye (I) containing at least one arylsulphonate (i.e. benzenesulphonate or naphthalenesulphonate) group. Also claimed is a method for suppressing the 32 degrees C transition point of AN, by incorporating 1-7% PN and 0.1-1% (I).
Patent DE-69703413-T2 (DE)
Inventor: GALLAGHER PETER THADDEUS
IPC: C07D413/14
Filed: 1997-06-25
Granted: 2001-03-15
Abstract: A pharmaceutical compound of the formula <CHEM> in which X is -CR'R"- or -C(O)- where R' and R" are each hydrogen, C1-6 alkyl or optionally substituted phenyl, Y is oxygen or sulphur, R<1>, R<2> and R<7> are each selected from halo, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, nitro, cyano, amino, phenyl, phenoxy, benzyl, benzyloxy, acylamino, C1-4 alkylsulphonylamino, C1-4 alkylthio, C1-4 alkylsulphonyl, carboxamido, sulphonamido, hydroxy, methylenedioxy, carboxy, and heteroaryl, R<3>, R<4>, R<5> and R<6> are each hydrogen, C1-6 alkyl or optionally substituted phenyl, n, m and p are each 0, 1, 2 or 3; or a salt or ester thereof.w
Patent DE-69706135-T2 (DE)
Inventor: KUMAR YATENDRA
IPC: C07D309/30
Filed: 1997-07-04
Granted: 2002-05-02
Abstract: Preparation of simvastatin of formula (I) comprises (i) treating a compound of formula (I') with an alkyl amide of formula R3NH2 to produce a compound of formula (III): R = a group of formula (a) or (b): R2 = H, Na, K or NH4; R3 = 3-6C n-alkyl or cycloalkyl; (ii) treating (III) with a methylating agent to produce a compound of formula (IV) and (iii) removing R3 and closing the pyranone ring to produce simvastatin. In step (iii) the R3 group is preferably cleaved by treating (IV) with a strong base e.g. sodium hydroxide followed by treatment with ammonium hydroxide and then treating with an organic solvent e.g. toluene and heating to give (IIa). The methylating agent in step (ii) is a methyl halide e.g. methyl iodide and methylation is in the presence of a base e.g. lithium pyrrolidide.
Patent DE-69706183-T2 (DE)
Inventor: O'NEILL A
IPC: C12Q1/68
Filed: 1997-10-02
Granted: 2002-04-11
Abstract: The invention relates to methods and compositions for simultaneously generating a plurality of polynucleotide sequencing ladders or PCR amplification products. Each sequencing ladder is generated from a recoverable primer, i.e., an oligonucleotide primer comprising a recovery tag. The recovery tag may be an oligonucleotide. Each sequencing ladder has a unique recovery tag. After the generation of the multiple sequencing ladders, the different sequencing ladders are separated from one another, i.e., purified, by binding to recovery tag binding compounds that have been immobilized on one or more solid supports. The recovery tag binding compounds are immobilized on the solid support in an addressable manner, i.e., the recovery tag binding compounds have distinct locations on the solid support. The binding of the sequencing ladders to the recovery tag binding compounds serves to separate the different polynucleotide sequencing ladders present in a given solution. The separated sequencing ladders may then be released from the immobilized recovery tag binding compounds and subsequently resolved into individual components of the sequencing ladders or PCR products. The subject methods of separating sequencing ladders simultaneously generated in the same vessel may readily be adapted to separate a plurality of simultaneously generated polynucleotide amplification products. Other aspects of the invention are kits for the generation or recovery of a plurality of polynucleotide sequencing ladders or amplification products. The kits comprise a plurality of recoverable primers having unique recovery tags. Preferably, the recovery tags are polynucleotides that have substantially the same denaturation temperature when bound to appropriate recovery tag binding compounds, i.e., the primers comprise an integrated set. The kits may further comprise recovery tag binding compounds. The kits may further comprise labeled chain terminators. Other aspects of the invention include polynucleotide recovery devices.
Patent DE-69713744-T2 (DE)
Inventor: JANSSON CONNY
IPC: B25G1/10
Filed: 1997-03-12
Granted: 2003-03-06
Abstract: PCT No. PCT/SE97/00423 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Mar. 12, 1997 PCT Pub. No. WO97/33724 PCT Pub. Date Sep. 18, 1997Handle for tools such as screwdrivers, cormprising a core of hard plastic material around a metal shaft and a gripping surface (14) of soft material covering parts of the core, where the core within the regions covered by the gripping surface is made with a multitude of protruding lower blocks (17) with flat tops, and the soft material filling the space between lower blocks to the level of the tops of lower blocks (17) to form base surface (16) and a multitude of blocks (15) raised from the base surface, arranged in a repetitive pattern with voids where the lower blocks protrude.
Patent DE-69715687-T2 (DE)
Inventor: DE ROOIJ WILHELMUS
IPC: G01N33/49
Filed: 1997-02-10
Granted: 2003-01-30
Abstract: A method and kit for separating plasma from small quantities of whole blood. A mixture of less than 100 mul of whole blood, a blood anticoagulant and a diluent, is formed in a container provided with a sealing cap. The mixture is forced through a filter containing glass fibers by applying sub-atmospheric pressure to a side of the filter opposite the mixture. The method can be performed in a hypodermic syringe, or in a capillary.
Patent DE-69720057-T2 (DE)
Inventor: THEEUWES FELIX
IPC: A61N1/30
Filed: 1997-12-16
Granted: 2003-09-25
Abstract: An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.
Patent DE-69721020-T2 (DE)
Inventor: DUGGER A
IPC: A61L15/44
Filed: 1997-02-21
Granted: 2003-12-04
Abstract: A buccal aerosol spray using a non-polar solvent has now been developed which provides nitroglycerin for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal aerosol spray of the invention comprises: propellant 50-95%, non-polar solvent 5-50%, nitroglycerin 0.001-15%, flavoring agent 0.05-5%.
Patent DE-69733024-T2 (DE)
Inventor: MORRIS G
IPC: A23L29/269
Filed: 1997-11-13
Granted: 2006-02-16
Abstract: Liquid, nutritionally complete formulas are disclosed with improved physical stability. The nutritionally complete formulas are pourable, yet are able to hold minerals, insoluble fiber and flavoring agents such as cocoa powder in suspension without the formation of a sediment that is not readily redispersible. The invention comprises the use of gellan gum at a concentration of between 10-500 parts per million. Although gellan gum alone is sufficient, the nutritionally complete formula may also comprise other stabilizers such as carrageenan and/or carboxymethylcellulose.
Patent DE-69735116-T2 (DE)
Inventor: VEZZA THOMAS F
IPC: C04B35/63
Filed: 1997-09-24
Granted: 2006-08-31
Abstract: This invention relates to cement-free refractories exhibiting high green strength, improved corrosion resistance, and improved magnesium oxide hydration resistance useful as refractory castables for steel ladles, slag contact areas, ladle sidewalls and bottoms, and the like and as precast refractory shapes, such as well blocks, nest blocks, and the like. More particularly, this invention is directed hydraulically-bonded monolithic refractories containing a calcium oxide-free binder comprised of a hydratable alumina source and magnesium oxide and which exhibit high green strength, improved corrosion resistance, improved magnesium oxide hydration resistance, and controllable work and set times.
Patent DE-69805507-T2 (DE)
Inventor: COOK JOHN
IPC: B41M5/00
Filed: 1998-02-16
Granted: 2003-01-16
Abstract: A transfer film (14) for transferring an ink comprising at least one liquid component. The film comprises a heat-activatable adhesive and an ink absorber, and may be mounted on a carrier film (12). The heat-activatable adhesive is in the form of a porous matrix bound together by the ink absorber. When an image is printed on the film, the film will absorb ink from the printer without spreading and blurring of the image. The surface of the film is then placed on the article (20) on which the image is to be transferred and heat applied. The activated adhesive then binds the film (14) to the article (20).
Patent DE-69806361-T2 (DE)
Inventor: FAGEBAUME OLIVIER
IPC: C04B35/52
Filed: 1998-03-25
Granted: 2003-02-13
Abstract: Methods for producing by electrochemical reduction a carbon-containing material with its surface modified by organic groups, in particular functionalized organic groups. Certain embodiments of the methods include contacting the carbon-containing material with an organic diazonium salt in solvent, optionally in the presence of an electrolyte and negatively polarizing the carbon-containing material relative to an anode also in contact with an electrolytic solution separate from said diazonium salt solution, wherein the electrochemical reduction is carried out on an organic diazonium salt in protic solvent in an acid medium. Carbon-containing materials with a surface modified by organic groups and the use of these modified materials, for example for producing composite materials or for fixing molecules of biological interest, are taught.
Patent DE-69812008-T2 (DE)
Inventor: ROHAUT SERGE
IPC: E06B9/84
Filed: 1998-07-27
Granted: 2004-01-15
Abstract: The anti-drop mechanism for a roller shutter door mounted on a horizontal shaft (1) comprises a fixed flange on the shaft and an adjacent rotary flange fixed to the shutter so that it rotates relative to the fixed flange as the shutter moves. The rotary flange has a number of centrifugal locking elements (25,26,27) in the form of spring-loaded and pivoted levers with end claws (25a) which engage with apertures (16,17) in a rim (12) on the fixed flange surrounding the levers when the normal operating speed of the shutter is exceeded.
Patent DE-69821415-T2 (DE)
Inventor: BENE BERNARD
IPC: A61M1/16
Filed: 1998-08-07
Granted: 2005-03-03
Abstract: The procedure for regulating the concentration of sodium in a dialysis fluid at a predetermined level so that the fluid inside the patient tends towards a desired concentration as the patient's blood and dialysis fluid are circulated on either side of a semi-permeable membrane (4) in a dialyser (1) consists of determining the concentration of sodium in the dialysis fluid, the desired concentration, the perfusion flow rate and the concentration in the perfusion fluid and adjusting the dialysis fluid concentration accordingly. The concentration of sodium in the dialysis fluid is determined from a set formula based on the desired concentration, the concentration in the perfusion fluid, the fluid flow rate and the dialyser separating capacity. The separating capacity is determined by circulating at least two dialysis fluids with different conductivities, taking two or more conductivity measurements before and after the dialyser, and calculating the separation capacity from the values obtained, using a second formula.
Patent DE-69829222-T2 (DE)
Inventor: BROWN J
IPC: B65B11/04
Filed: 1998-12-03
Granted: 2006-04-06
Abstract: Apparatus for stacking bales of hay into large bundles such as, for example, three bales high and seven bales wide, positions bands about the stacked array to provide a tightly bound, compressed stack of bales. The stacking apparatus compresses the stacked bales during banding with a greater force applied to the same facing portions of the bales as applied during formation of the bales to form a solid, rigid, self-supporting large bundle made up of small bales. Parallel spaced compression zones extending inwardly are formed in the upper and lower rows of bales in the least compressed portion of the bales for receiving the bands which are applied without high tension so as not to damage the hay in holding the bundle of hay bales together. This arrangement prevents the bands from cutting into the hay bales as well as severing the binding of the individual bales, allows the hay bundle to be easily moved by pallet forks, and maintains the banding out of contact with the ground to avoid band damage and deterioration from the elements as well as from rodents. The apparatus is computer controlled and fully automated from the input of individual bales to the discharge of a tightly banded and compressed bundle of hay bales and can be used in "on the go" as the apparatus traverses a field containing the individual hay bales.
Patent DE-69830855-T2 (DE)
Inventor: BIEDERMANN ELFI
IPC: A61K31/4439
Filed: 1998-12-16
Granted: 2006-05-24
Abstract: The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.
Patent DE-69833157-T2 (DE)
Inventor: THACHARODI DILIP KUMAR
IPC: A61K47/32
Filed: 1998-12-07
Granted: 2006-08-31
Abstract: A pharmaceutical composition which is stable and suitable for oral administration to a patient comprises a mixture of a substituted pyridyl sulfinyl benzimidazole having gastric acid secretion inhibitory activity (such as omeprazole, lansoprazole, or pantoprazole), and a pharmaceutically acceptable carrier. The carrier comprises a polymer having vinyl pyrrolidone monomeric units, such as polyvinylpyrrolidone or a vinyl pyrrolidone-vinyl acetate copolymer. Surprisingly, it has been found that the vinylpyrrolidone polymer acts as a stabilizing excipient on the substituted pyridyl sulfinyl benzimidazole so that the composition need not include any alkaline components to prevent degradation of the active ingredient. In a preferred embodiment, the composition is in the form of a capsule, whereby the mixture of the substituted pyridyl sulfinyl benzimidazole and the vinyl pyrrolidone polymer in the form of a powder blend or granules, is contained within a capsule shell, which capsule shell is made from an enteric material or is coated with an enteric material. A process for preparing the stable pharmaceutical composition is also disclosed.
Patent DE-69902761-T2 (DE)
Inventor: FRANKE G
IPC: B29C48/09
Filed: 1999-03-04
Granted: 2003-05-15
Abstract: Biodegradable sorghum meal-based extruded shaped products or articles and methods of manufacturing the same. In particular, extruded sorghum meal-based products processed by compression, stretching or compression and stretching provide excellent flexibility, pliability, dimensional stability, resiliency, abrasion resistance and other properties making them attractive for use as packaging materials.
Patent DE-69903316-T2 (DE)
Inventor: VOULAND PATRICE
IPC: B25B5/12
Filed: 1999-07-19
Granted: 2003-06-18
Abstract: The device includes a hollow pilot equipped with at least two retractable hooks and driven by a piston provided with a groove, the whole assembly being mounted on a supporting nosepiece. The piston is locked in clamping position by a three-point system actuated by a pneumatic cylinder. The device assembly is integrated in a housing. The device is designed to equip fixed or mobile posts for assembling vehicles, or clamping arms.
Patent DE-69904813-T2 (DE)
Inventor: LUDTKE A
IPC: H04L29/06
Filed: 1999-04-29
Granted: 2003-10-02
Abstract: A media manager provides data flow management and other services for client applications on devices coupled together within a network. Preferably, these devices are coupled together within an IEEE 1394-1995 serial bus network. A device control module is generated for each available device for providing an abstraction for all of the capabilities and requirements of the device including the appropriate control protocol, physical connections and connection capabilities for the device. The media manager also manages the flow and format of data transfers between the devices on the network. Through an interface, a user accesses the media manager and enters functions which are to be completed using the devices coupled together on the network. If the appropriate devices are available, the media manager controls and manages the completion of the requested task. If the appropriate devices are not available, but the required subdevices are available in multiple devices, the media manager forms a virtual device from subdevices in multiple devices in order to complete the requested task. Once the appropriate devices and subdevices are assigned to a task, the media manager determines if the data to be transmitted needs to be converted from one format into another format. If necessary, the media manager will also control the format conversion during the data transfer operation. The media manager also provides network enumeration and registry searching capabilities for client applications to find available services, physical devices and virtual devices.
Patent DE-69907923-T2 (DE)
Inventor: MERCHANT KEVIN JOHN
IPC: A61K31/5025
Filed: 1999-08-20
Granted: 2004-02-12
Abstract: A compound of formula I, or a salt or prodrug thereof:wherein:Z represents C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, aryl, C3-7 heterocycloalkyl, heteroaryl or di(C1-6)alkylamino, any of which groups may be optionally substituted;R1 represents an optionally substituted five-membered heteroaromatic ring selected from oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; orR1 represents an optionally substituted six-membered heteroaromatic ring selected from pyrazine, pyrimidine and pyridazine; andR2 represents cyano(C1-6)alkyl, hydroxy(C1-6)alkyl, C3-7 cycloalkyl(C1-6)alky, propargyl, C3-7 heterocycloalkylcarbonyl(C1-6)alkyl, aryl(C1-6)alkyl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted; its use in treating anxiety and pharmaceutical compositions comprising it; a subclass of compounds which are useful in enhancing cognition, such as Alzheimer's Disease, is also disclosed.
Patent DE-69916816-T2 (DE)
Inventor: EXNER THOMAS
IPC: C12Q1/56
Filed: 1999-02-01
Granted: 2004-09-30
Abstract: A method of determining the coagulation potential of a plasma sample be pre-incubating the plasma sample with a reagent such that endogenous protein C in the plasma is at least partially converted into activated protein C by the reagent, adding factor Xa which is progressively inactivated by antithrombin III/heparin cofactor 2 during the preincubation, adding an exogenous reagent which activates factor X to Xa or prothrombin to thrombin in a factor V-dependent manner, monitoring a reaction indicative of the rate of coagulation of the plasma sample, comparing that rate of coagulation control, or the equivalent rate determined for an individual without impaired coagulation control, or the equivalent rate determined for the plasma sample in the absence of protein C activator, and determining the coagulation potential of the plasma sample from one or other of the compairsons.
Patent DE-69917918-T2 (DE)
Inventor: RAGHU SURYA
IPC: F15C1/22
Filed: 1999-10-15
Granted: 2005-06-23
Abstract: A fluidic oscillator includes a member having an oscillation inducing chamber, at least one source of fluid under pressure, at least a pair of power nozzles connected to the at least one source of fluid under pressure for projecting at least a pair of fluid jets into the oscillation chamber, and at least one outlet from the oscillation chamber for issuing a pulsating or oscillating jet of fluid to a point of utilization or ambient. A common fluid manifold connected to said at least a pair of power nozzles. The shape of the power nozzle manifold forms one of the walls of the interaction or oscillation chamber. In some of the fluidic circuits, the length can be matched to fit existing housings. The power nozzle can have offsets which produce yaw angles in a liquid spray fan angle to the left or right depending on the direction desired. In some embodiments, the exit throat is off axis (off the central axis of the symmetry) by a small fraction to the left or right to move the leftward or rightward yaw angles in the spray. The outlet throat may be offset along the longitudinal axis by a small amount to produce a yaw angle of predetermined degree to the left or right depending on what is desired. Thus, one can construct circuits for yaw using a combination of the techniques described above which suits most applications.