Patent SG-11201407711Q-A (SG)
Title: Process for the production of methyl methacrylate
Inventor: EASTHAM GRAHAM RONALD
IPC: C12N9/02
Filed: 2013-05-24
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/179005 A1 (51) International Patent Classification: C12P 7/62 (2006.01) C12N 9/02 (2006.01) (21) International Application Number: PCT/GB2013/051376 (22) International Filing Date: 24 May 2013 (24.05.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1209425.6 28 May 2012 (28.05.2012) GB (71) Applicant: LUCITE INTERNATIONAL UK LIMITED [GB/GB]; Cumberland House, 15-17 Cumberland Place, Southampton, Hampshire SO 15 2BG (GB). (72) Inventors: EASTHAM, Graham, Ronald; Wilton Centre, Wilton, Redcar TS10 4RF (GB). JOHNSON, David, Wil­ liam; Wilton Centre, Wilton, Redcar TS10 4RF (GB). STRAATHOF, Adrianus, Johannes, Jozef; Agatha van Leiderlaan 13, 2628 LG Delft (NL). FRAAIJE, Marco Wilhelmus; Molecular Enzymology Group, Biochemical Laboratory, Groningen Biomolecular Sciences and Bio­ technology Institute, University of Groningen, Nijenborgh 4 9749 AG Groningen (NL). WINTER, Remko, Tsjibbe; Molecular Enzymology Group, Biochemical Laboratory, Groningen Biomolecular Sciences and Biotechnology In­ stitute, University of Groningen, Nijenborgh 4 9747 AG Groningen (NL). (74) Agent: APPLEYARD LEES; 15 Clare Road, Halifax, West Yorkshire HX1 2HY (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: PROCESS FOR THE PRODUCTION OF METHYL METHACRYLATE Figure 1. Conversion of different concentrations of 2-butanone by 5 pM CHMO. Each reaction in 1 mL 50 mM Tris-HCI, pH 7.5, containing 100 uM NADPH and 10 mM Na HP0 2 3 at room temperature for 24 hours. Ratio Ethyl Acetate: Methyl Propionate formed by CHMO 4-5 I 4 • : \" f 2.5 2 • # # t 1.5 - * # 1 Q 200 400 600 800 1000 1 3 3'\"' in © | [2~Biitarione] (mM) Ov t l> i-H m i-H (57) Abstract: A process of producing methyl methacrylate or derivatives thereof described. The process includes is the steps of; (i) ® converting 2-butanone to methyl propionate using Baeyer-Villiger a monooxygenase, and (ii) treating the methyl propionate pro - ^ duced to obtain methyl methacrylate or derivatives thereof. A method of preparing polymers or copolymers of methyl methacrylate O or its derivatives also is described. WO 2013/179005 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll llll llll lllll lllll lllll lllllll llll llll Published: — with international search report (Art. 21(3))