Patent SG-11201806120W-A (SG)
Title: Ror1 antibody compositions and related methods
Inventor: RADER CHRISTOPH
IPC: C07K16/28
Filed: 2017-01-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011101011111110110011111111101111011111 International Bureau ... .1 j ..... .....1 (10) International Publication Number (43) International Publication Date WO 2017/127664 Al 27 July 2017 (27.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) A61K 39/395 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 14/725 (2006.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/014311 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 20 January 2017 (20.01.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/280,843 20 January 2016 (20.01.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: THE SCRIPPS RESEARCH INSTITUTE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 10550 North Torrey Pines Road, La Jolla, CA TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 92037 (US). NBE-THERAPEUTICS AG [CH/CH]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Hochbergerstr, 60c, CH-4057 Basel (CH). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: RADER, Christoph; 144 Victorian Lane, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Jupiter, FL 33458 (US). PENG, Haiyong; 1200 Town SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Center, #312, Jupiter, FL 33458 (US). BEERLI, Roger; GW, KM, ML, MR, NE, SN, TD, TG). Rebrainstrasse 34, CH-8106 Adlikon (CH). WALDMEI- Published: ER, Lorenz; Peter-rot-strasse 74, CH-4058 Basel (CH). — with international search report (Art. 21(3)) GRAWUNDER, Ulf; Weidweg 1, CH-4423 Hersberg — with sequence listing of description (Rule 5.2(a)) (CH). part (74) Agents: FITTING, Thomas et al.; The Scripps Research Institute, 10550 North Torrey Pines Road, Tpc-8, La Jolla, CA 92037 (US). (54) Title: ROR1 ANTIBODY COMPOSITIONS AND RELATED METHODS ROR1 mobs Vr F1 CDR: Paz CDA2 SR3 CDR3 PR4 21 tit 88 90 10' ' ,14SMICM21,1 Ma: 324 iTLIlagTHR: GIMIK 141 -71 (7M1 *MC Lai245gM1ll4 Fmcantul, 11M-111E40 DIragTHMI ?.T1144 gi111S1DST 1.h M AS Mf. , Hmr. IMMIT1IIVIA FOMMIF VI, CORI CDR3 FRI 23 98 107 'X961.-4D1 — 'Sal -Aux [MIMS. WHAM, PI:kit -01PM. M1-301 Mg 30C MI MI vl MAK ' IlitTC G • ERNI me ni_____... . EaRI oim: , 4 iSi1 GOROM.414. .IMM, 4•GL.Ln - — MU 1OH4 51M1LUMMOMM GMMICMI— 1191MOLARILI WISCV. , -- ' Alrft: '' IT PH PR2 CP.2 MI -402 Il Elik1-30' .4 1211i1-3 Ml. 7r IN el 1-1 FIG. 1 IN 1-1 (57) : ROR1 Antibody Compositions and Related Methods The disclosure provides antibodies, antibody drug conjugates, N antibody-based fragments or antibody fragments (antigen-binding fragments), as well as antibody drug conjugates (ADCs) and chi- meric antigen receptors (CARs), that specifically recognize human ROR1 and related compositions. Also provided in the disclosure C are methods of using such antibodies in various diagnostic and therapeutic applications.