baber/WOPTO huggingface dataset:
Patent RU-2415134-C9 (RU)
Title: Способ лечения или профилактики физиологических и/или патофизиологических состояний, опосредуемых рецепторами, стимулирующими секрецию гормона роста, триазолы и фармацевтическая композиция на их основе
Inventor: BEGLEN DAM EN
IPC: C07D401/14
Filed: 2006-08-11
Granted: 2011-05-27
Abstract: Настоящее изобретение относится к использованию соответствующих формуле (I) новых производных триазола в качестве грелин-подобных лигандов рецепторов, стимулирующих секрецию гормона роста (ССГР рецепторы), что может быть полезно при лечении или профилактике физиологических и/или патофизиологических состояний у млекопитающих, предпочтительно, людей, которые опосредуются ССГР рецепторами. 
     формула (I): 
     
       
     
     где 
     R1 выбирают из группы, включающей атом водорода, (С1-С12)алкил фенил, нафтил, (С5-С14)фенил(С1-С12)алкил, индолилалкил, которые могут содержать до 3 заместителей, независимо выбранных из группы, включающей галоген, -F, -Сl, -Br, -I, -NO 2 , (С1-С12)алкил, фенил, нафтил, -O-(С1-С12)алкил; R2 выбирают из группы, включающей (С1-С12)алкил, фенил, нафтил, (С5-С14)фенил(С1-С12)алкил, индолилалкил, которые могут содержать до 3 заместителей, независимо выбранных из группы, включающей галоген, -F, -Сl, -Br, -I, -NО 2 , (С1-С12)алкил, фенил, нафтил, -O-(С1-С12)алкил; один из радикалов R3 и R4 представляет собой атом водорода, а другой радикал выбирают из группы, включающей атом водорода, фенил, нафтил, индолилалкил; R5 выбирают из группы, включающей атом водорода, фенил, нафтил, -СО-(С3-С8)циклоалкил, -СО-фенил, -СО-(С5-С7)гетероарил, содержащий 1, 2 атома азота, -СО-(С3-С7)гетероарил(С1-С4)алкил, содержащий 1, 2 атома азота, -СО-(С5-С6)гетероциклил, содержащий 1, 2 атома азота или кислорода, - CO-C*(R9R10)-NH 2 , -CO-CH 2 -C*(R9R10)-NH 2 , -CO-C*(R9R10)-CH 2 -NH 2 , фенилсульфонил, которые могут содержат до 3 заместителей, независимо выбранных из группы, включающей галоген, -F, -Сl, -Вr, -I, -N 3 , -CN, -NR7R8, -ОН, -NO 2 , (С1-С4)алкил; R6 представляет собой атом водорода; R7 и R8 представляют собой атом водорода; R9 и R10 независимо выбирают из группы, включающей атом водорода и (С1-С4)алкил; m соответствует 0, 1 или 2, и, предпочтительно, 0; и * означает атом углерода в R или S конфигурации, если он хирален. Настоящее изобретение также относится к антагонистам и агонистам ССГР рецепторов, которые могут использоваться для модуляции этих рецепторов и полезны для лечения указанных выше состояний, в особенности, замедление роста, кахексию, краткосрочное, среднесрочное и/или долгосрочное регулирование баланса энергии; краткосрочное, среднесрочное и/или долгосрочное регулирование (стимулирование и/или ингибирование) потребления пищи; адипогенез, тучность и/или ожирение; увеличение и/или снижение веса тела у млекопитающих. 3 н. и 19 з.п. ф-лы, 6 табл., 46 ил.
Patent DK-39286-D0 (DK)
Inventor: CALDERON PIEDAD
IPC: C07D233/58
Filed: 1986-01-27
Abstract: Derivatives of imidezole corresponding to formula I 
<CHEM>
 wherein X<1>, X<2>, Y<1> and Y<2>, whether or not identical can have different significancies, R<1> is hydrogen, a methyl or phenyl group, R<2> and R<3>, whether or not identical represent hydrogen, a hydroxyl, alkyl or alkoxy group, it being possible for R<1> and R<2> together to represent a carbon-carbon bond, R<4> and R<5>, whether or not identical, being hydrogen or alkyl, and the tautomers and salts of these compounds, also the pharmaceutical compositions containing them. 
<??>The compounds are endowed with  alpha 2-blocking and/or anti-convulsive activities and are utilisable as therapeutic agents for man.
Patent DK-50588-D0 (DK)
Inventor: SKEIE EINAR
IPC: A61B17/11
Filed: 1988-02-01
Abstract: A prosthesis for use in joining hollow, e.g. tubular, organ parts or systems, said prosthesis comprising a fragmentable body defining outer organ-supporting surface parts thereon adapted to be arranged in abutting relationship with inner surface parts of the organs to be joined, said body having a compressive strength sufficiently low to allow fragmentation of the body by application of a pressure to the outer surface of the tubular organs subsequently to the joining of the same, said pressure being below a pressure causing any substantial lesion of the tissue of the tubular organ parts. The material of the prosthesis is preferably one or more degradable and/or erodable and/or water-soluble, essentially non-toxic materials which are solid at a temperature of 40 DEG C or higher, in particular 60 DEG C or higher, the material preferably being a polyether, more preferably a polyglycol, in particular polyethylene glycol such as polyethylene glycol with an average molecular weight of from 10,000 to 35,000, especially about 20,000. As shown in Fig. 3, the prosthesis (1) may have tapered outer ends (3) as well as an intermediary portion (4) between the organ-supporting parts and having a smaller diameter. In another embodiment as shown in Fig. 9 or Fig. 13, the end portions may consist of longitudinally and inwardly radially extending fins (11) to give the prosthesis tapering end portions. In a further embodiment, the prosthesis may be a section of tubing with ends cut at an oblique or right angle.
Patent DK-83891-D0 (DK)
Inventor: POULSEN OLAF BROENDEN
IPC: D06F58/50
Filed: 1991-05-07
Abstract: The clogging of the lint filter of a tumbler dryer with lint and fluff from the laundry being dried causes a reduction of the air transport exceeding that caused by the filling with laundry. This necessitates more frequent regulation of the input temperature (27) to the drum of the tumbler dryer than if the lint filter were clean or totally removed. It is therefore possible to measure the frequency of regulation and compare it to a value obtained by experience gained by drying operations with a clean lint filter. If the frequency of regulation is too high an alarm is triggered, indicating the requirement for cleaning the lint filter. <IMAGE>
Patent DK-181783-D0 (DK)
Inventor: KALINA VLADIMIR
IPC: C12M1/04
Filed: 1983-04-25
Abstract: Alcohol is produced by continuous fermentation process in which must is fermented in a vat. Fresh must is introduced into the vat and fermented must is withdrawn from the vat. Fermented must withdrawn from the vat is pumped from the vat in a pumping column of a circuit extending above the vat in which carbon dioxide exerts mammoth pumping action. A back pressure is maintained and adjusted in an upper portion of the vat which is connected with the pumping column for concentrating carbon dioxide in the vat and for controlling the flow rate of the mammoth pumping column and the circulation speed of the must in the circuit. The pumping column is connected with a pipe which is connected to a lower portion of the vat which completes the circuit and which is disposed for effecting a turbulent flow of the carbon dioxide depleted must and for returning recycled must to the vat. Carbon dioxide is separated from the must in the pumping column and exerts the mammoth pumping action. A mixture of oxygen and inert gas is introduced into the turbulent flow of must in an upper portion of the return pipe.
Patent DK-211786-D0 (DK)
Inventor: SAVENIJE FRANCISCUS GERHARDUS
IPC: A47C20/04
Filed: 1986-05-07
Abstract: Locakable piston-cylinder assembly to be mounted between two parts being movable relative to each other such as a frame and top or foot end of a bed structure. The two chambers (7, 8) resulting from the division of piston (2) in cylinder (1) are interconnected by a hollow piston rod (3) provided with openings (9 and 10). At least one of these openings can be closed by valve member (4) arranged in said piston rod and so connection between these chambers (7, 8) is controlled. Valve member (4) is actuatable from one end of piston rod (3) outside cylinder (1). For obviating undesired pressure build up in space (20) or for controlling the pressure in this space a connection (14) is provided to the exterior of cylinder (1).
Patent DK-250084-D0 (DK)
Inventor: HUTCHISON ALAN JEFFREY
IPC: C07D487/10
Filed: 1984-05-22
Abstract: A series of novel spiro-oxindole imidazolidinedione derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductose inhibitors for the control of certain chronic diabetic complications. Preferred compounds include 6'-amino-spiro- [imidazolidine-4,3'-indoline] -2,2', 5-trione, 5'-chloro -7'-amino-spiro [imidazolidine-4,3'-indofine) -2,2', 5-trione, 1'- (3-pyridylmethyl) -5'-fluoro-spiro [imidazolidine-4,3'-indoline) -2,2',5-trione, 1'- (3-pyridylmethyl) -5',7'-dichloro-spiro- [imidazolidine-4,3'( indoline] -2,2',5-trione and spiro- [imidazolidine-4,3'- (6- azaindoline)1 -2,2',5-trione. Methods for preparing these compounds from known starting materials are provided.
Patent DK-311889-D0 (DK)
Inventor: SCHEIDSTEGER OLAF
IPC: B01J23/24
Filed: 1989-06-23
Abstract: In a process for eliminating nitrogen oxides from combustion exhaust gases which contain arsenic compounds as impurities, by selective catalytic reduction with ammonia, a catalyst is used which essentially contains titanium oxide and catalytically effective quantities of compounds of vanadium, molybdenum, tungsten and zinc. The catalyst contains A) titanium in the form of oxides, B) vanadium in the form of oxides or sulphates, C) molybdenum and/or tungsten in the form of oxides and D) zinc in the form of oxides or sulphates, with the proviso that the metal components A to D are present in the A/B/C/D atomic ratios of 1/0.0022-0.0165/0.021-0.21/0.009-0.028.
Patent DK-379483-D0 (DK)
Inventor: HOEGLUND INGOLF
IPC: F15B15/14
Filed: 1983-08-19
Abstract: A pressure fluid cylinder without a piston rod and of the kind having a slotted cylinder tube (1) and a piston displaceable therein, said piston being connected to a movement transfer device, which extends radially through the slot. The slot is sealed axially on each side of the piston by means of internal and external sealing strips (31,32) consisting of a flexible sealing band (37, 38) as well as retention means (44,45) extending into the slot and securing a releasable mechanical engagement with each other or, by friction, with the side walls of the slot.
Patent DK-493989-D0 (DK)
Inventor: SPENCER KENNETH G
IPC: A23L17/60
Filed: 1989-10-06
Abstract: Pigment compositions useful for supplementing marine animal feeds comprise comminuted Haematococcus cells treated to degradation of carotenoids, typically by coating or by combination with an anti-oxidant. Encysted Haematococcus cells are ground at cryogenic temperatures, typically by combining the cells with liquid nitrogen in a suitable impact mill. The resulting powder has an average particle size below about 5  mu m. Usually, the Haematococcus will be grown in large-scale culture ponds under controlled conditions.
Patent DK-571683-D0 (DK)
Inventor: QUINLAN JAMES MICHAEL
IPC: A61K9/08
Filed: 1983-12-12
Abstract: This invention relates to aqueous gels, which remain gelatinous in a temperature range as low as -270 DEG C containing dl- or 1-6-phenyl-2,3,5,6-tetrahydro-(-)imidazo [2,1-b]thiazole, acylamino derivatives thereof and pharmaceutically acceptable salts thereof, characterized by gelation and preparation at ambient temperatures (20-60 DEG C), under vacuum, without additional heating or cooling in their preparation.
Patent DK-585687-D0 (DK)
Inventor: HALVERSON HENRY J
IPC: F42B14/06
Filed: 1987-11-09
Abstract: A high velocity ammunition sabot (16) of brittle material which has sufficient strength to withstand the forces of being launched from a rifled gun barrel but which fragments almost immediately upon exit from the barrel due to centrifugal forces. A polyetherimide material is preferred, although materials of equivalent properties could be used.
Patent HU-911895-D0 (HU)
Title: Process for producing (1-aryl-pyrrolidine-2yl)-methyl-piperazine derivatives and pharmaceutical prepartives containing these compounds
Inventor: GEORGE PASCAL
IPC: A61K31/495
Filed: 1991-06-06
Abstract: [(1-Arylpyrrolidin-2-yl)methyl]piperazine compounds corresponding to the formula   <IMAGE> (I)  in which Z denotes a group of formula N-R1 in which R1 is either a hydrogen atom or a C1-3 alkyl group or a group of formula Ar-CnH2n in which n denotes 0, 1 or 2 and Ar denotes a phenyl group optionally substituted by one or more halogen atoms and/or C1-3 alkyl or C1-3 alkoxy radicals, or a group of formula COR2 in which R2 denotes the CH3, C6H5, CH2C6H5 or OC2H5 group and their salts of addition to pharmaceutically acceptable acids. The compounds are useful for the treatment of neurological disorders.
Patent HU-912515-D0 (HU)
Title: Process for the production of biofunctional cosmid for cloning dna of aktinomicetic origin
Inventor: RYAN MICHAEL J
IPC: C12N15/55
Filed: 1991-07-26
Abstract: The present invention relates to novel and useful cosmids for cloning and expressing the isolated DNA gene cluster which directs the synthesis of tetracycline and chlortetracycline, in a heterologous host such as Streptomyces lividans. The claimed plasmids (cosmids) are isolated by screening a cosmid library, constructed in Escherichia coli, for the expression of tetracycline resistance in S. lividans. Plasmids LP<2>127 and LP<2>128 are recovered from such tetracycline-resistant S. lividans isolates shown by HPLC analysis of agar and broth fermentations to direct the synthesis of tetracycline and chlortetracycline.
Patent NO-914768-D0 (NO)
Inventor: DOEMER JOSEF
IPC: H04B17/40
Filed: 1991-12-04
Abstract: For the monitoring information transmitted via a teleaction channel also to be provided to the processor units of repeater stations without address-controlled call-up, the monitoring information from all operating stations is continuously kept available in all processor units and at least a predetermined part of the stored monitoring information is sequentially sent out to the adjoining processor units. <IMAGE>
Patent NO-930524-D0 (NO)
Inventor: GLANSK LEIF
IPC: F24H9/12
Filed: 1993-02-15
Abstract: A combined control and regulating valve (1) having a housing (2) with an inlet (3) and an outlet (4) as well as a partition (5) between said inlet and outlet and having a seat (6) designed for an interaction with a main valve body (7), which is adjustable from outside. To said inlet and said outlet are connected a measuring nipple each (50 and 74, respectively) via a bore (30, 31 and 40, 41 respectively) for the measurement and the control of temperature and/or pressure. One of the measuring nipples is designed as a multiple function nipple (50) having a cut-off-valve permitting tapping and filling of the medium, which is to be controlled/regulated. In order to enhance reliability in operation, to provide even more precise and reliable measuring results, to reduce the risk of clogging of the cavities leading to the measuring nipples, to reduce costs for manufacturing and/or fitting, to provide preconditions for various conditions of operation and for partial changes as well as for being able to affect other valve properties, like sealing properties and use of differently designed or dimensioned valve bodies, at least one bore (30, 31) is extended axially to communicate with a so extended portion (110) with a zone of the medium channel (73) downstream of said seat (6) via an area immediately above said valve body (7) or around said seat (6) by means of a casing provided with a groove.
Patent NO-944999-D0 (NO)
Inventor: BUSCH FRANK ROBERT
IPC: C07J71/00
Filed: 1994-12-23
Abstract: PCT No. PCT/US93/02812 Sec. 371 Date Dec. 20, 1994 Sec. 102(e) Date Dec. 20, 1994 PCT Filed Apr. 2, 1993 PCT Pub. No. WO94/00479 PCT Pub. Date Jan. 6, 1994Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting  alpha -cellobiosyl bromide heptaalkanoate and  beta -tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl  beta -O-cellobioside heptaalkanoate. The analogous preparations of hecogenin  beta -O-cellobioside heptaalkanoate 11-ketotigogenin  beta -O-cellobioside heptaalkanoate, and diosgenin  beta -O-cellobioside heptaalkanoate are also disclosed. The process provides both high  beta -anomeric selectivity and high yields.
Patent NO-962064-D0 (NO)
Inventor: COLLOMB JOELLE
IPC: C08F10/00
Filed: 1996-05-21
Abstract: The present invention relates to a process for preparation of a catalyst of Ziegler-Natta type comprising a refractory oxide support. The process comprises the following stages: (a) and (b) contacting the support in the course of two separate stages with a dialkylmagnesium and with an organoaluminium compound in any order, (c) contacting the product resulting from (a) and (b) with an organic halogen compound, and (d) contacting the solid resulting from (c) with at least one tetravalent titanium compound. The invention also relates to an olefin polymerization process using the catalyst. The resulting polymers have an improved bulk density.
Patent NO-972152-D0 (NO)
Inventor: BROWN DEARG SUTHERLAND
IPC: C07D401/12
Filed: 1997-05-09
Abstract: PCT No. PCT/GB95/02606 Sec. 371 Date May 12, 1997 Sec. 102(e) Date May 12, 1997 PCT Filed Nov. 8, 1995 PCT Pub. No. WO96/15118 PCT Pub. Date May 23, 1996The invention concerns aniline derivatives of formula I    <IMAGE>  (I)  wherein m is 1, 2 or 3, n is 0, 1, 2 or 3, Q is phenyl or naphthyl or a 5- or 6-membered heteroaryl moiety containing 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, and X, R1 and R2 are defined in the claims; or pharmaceutical compositions containing them, and the methods of using the compounds as tyrosine kinase inhibitors and for the treatment of proliferative diseases such as cancer.
Patent NO-974650-D0 (NO)
Inventor: BLOT ESTELLE
IPC: C09D135/02
Filed: 1997-10-08
Abstract: PCT No. PCT/FR96/00610 Sec. 371 Date Oct. 20, 1997 Sec. 102(e) Date Oct. 20, 1997 PCT Filed Apr. 22, 1997 PCT Pub. No. WO96/33241 PCT Pub. Date Oct. 24, 1996The invention concerns paint compositions for providing road markings, in particular on wet roadways. The paint compositions essentially comprise: at least one unsaturated polyester; at least one ethylenically unsaturated monomer; at least one polymerization accelerator selected from toluidine derivatives; at least one colored pigment; at least one compound which can exude at the surface of the paint and prevent oxygen in the air from inhibiting polymerization; glass beads and dibenzoyl peroxide.
Patent NO-980884-D0 (NO)
Inventor: EKLUND ANDERS
IPC: E05C9/04
Filed: 1998-02-27
Abstract: PCT No. PCT/SE96/01078 Sec. 371 Date Apr. 7, 1998 Sec. 102(e) Date Apr. 7, 1998 PCT Filed Aug. 30, 1996 PCT Pub. No. WO97/08043 PCT Pub. Date Mar. 6, 1997The invention relates to a lock system for locking theft attractive property to fixed, preferably immovable objects (3), such as buildings, posts, etc., with the aid of an anchoring member (2) and a user-carried separate lock (6). The anchoring member (2) includes a first end (2a) which may be connected fixedly to the fixed object or the property. The anchoring member (2) also includes a second end (2b) which with the aid of the lock (6) may be locked either directly to a part of the property or to the fixed object subsequent to having passed an intermediate part (2c) of the anchoring member around a part of the property.
Patent NO-980925-D0 (NO)
Inventor: DOBSON JR JAMES W
IPC: C09K8/52
Filed: 1998-03-04
Abstract: The invention provides: (1) a process to enhance the removal of solids such as clays, clay-like solids, and shale solids-drill solids-from the surface of a borehole, the solids being deposited from well drilling, completion, or workover fluids during well servicing operations; and (2) a process to enhance the removal of such solids from screens or other sand control devices present in a borehole. The process comprises contacting the solids with an acidic soak solution containing a polyglycol or mono ether derivative thereof and thereafter contacting the surface of the borehole with a wash solution to remove the solids from the borehole.
Patent GB-0105148-D0 (GB)
Title: Active Matrix Display Device
IPC: G02F1/133
Filed: 2001-03-02
Abstract: A display has circuitry (50) which generates all possible pixel drive signal levels on separate signal level lines. A buffer (54) is associated with each signal level line. The outputs of the buffers are selectably switchable onto the columns. The signal levels for each column are stored in a memory (72) and the buffers are controlled in dependence on the stored signal levels. The response of the buffers is heavily dependent on the output load, and there is a very large variation in the output load of the buffers (54), as a function of the number of columns to which the buffer output is to be provided. The buffers are controlled in dependence on stored signal levels to ensure stability of the buffers for any output load.
Patent GB-0130955-D0 (GB)
Title: Expression system
IPC: A61P31/14
Filed: 2001-12-24
Abstract: The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine residues. The invention also provides for vectors, cells and non-human transgenic animal comprising the polynucleotides of the invention as well as their use in medicaments for various conditions.
Patent GB-0215384-D0 (GB)
Title: Improvements in metal salts
IPC: C07C51/487
Filed: 2002-07-04
Abstract: Alkali metal carboxylate salt brines, such as cesium formate brine, are used in oil and gas drilling procedures. Contamination with chloride ions can be controlled by treatment with a silver salt solution, and removing silver chloride formed. High density brines can be obtained, suitable for re-use.
Patent GB-0300056-D0 (GB)
Title: Image sensor
IPC: H04N3/15
Filed: 2003-01-03
Abstract: An image sensor has a plurality of pixels, each pixel having a photodiode (12), a voltage amplifier (16) having gain greater than 1 and a sampling capacitor (18) charged by the voltage amplifier. In this arrangement, each pixel provides gain through voltage amplification. This enables the sampling capacitor (18) to be kept to a low size, so that the pixel circuitry occupies the smallest possible space, thereby enabling large aperture pixels to be formed.
Patent GB-0325668-D0 (GB)
Title: Intensified and minaturized gasifier with multiple air injection and catalytic bed
IPC: C10J3/66
Filed: 2003-11-04
Abstract: A method for the gasification of solid fuel to produce combustible effluent, comprising the steps of: partially oxidizing a biomass fuel in a first oxidation zone to produce char; reducing the char in a reduction zone to form ash; further oxidizing any char residue ash in a second oxidation zone; and extracting the combustible effluent produced in the above steps, by a discharge pipe wherein in the first oxidation zone the gas flow is in the same direction as fuel flow and in the second oxidation zone the gas flow is in the opposite direction to the fuel flow.
Patent GB-0518117-D0 (GB)
Title: Apparatus and method of controlling motion and vibration of a sensor in a drilling assembly
IPC: E21B47/01
Filed: 2004-03-10
Abstract: A system for controlling sensor motion during a time-dependent measurement, comprising a drilling assembly having a drill bit at one end and engaged with a drill string extending to a surface location at an opposite end thereof. A sensor is disposed in the drilling assembly for making a measurement of a formation parameter of interest. A non-rotating stabilizer is disposed in the drilling assembly proximate the sensor. The non-rotating stabilizer is adapted to reduce motion of the sensor below a predetermined level during the measurement. In one embodiment the rotational axis of the stabilizer is eccentric with respect to the borehole. In another embodiment, the non-rotating stabilizer has an extendable rib for changing the effective diameter of the stabilizer.