baber/WOPTO huggingface dataset:
Patent WO-2021119034-A1 (WO)
Inventor: WU BIN
IPC: C12N15/113
Filed: 2020-12-08
Abstract: The present invention relates to RNAi constructs for reducing expression of the  LPA  gene, which encodes apolipoprotein(a), a component of lipoprotein(a) (Lp(a)) particles. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease, peripheral artery disease, stroke, and myocardial infarction, and to reduce serum Lp(a) levels are also described.
Patent WO-2021119545-A1 (WO)
Title: Vaccination durable
Inventor: JOOSS KARIN
IPC: A61K48/00
Filed: 2020-12-11
Abstract: L'invention concerne des compositions qui comprennent des peptides antigéniques et/ou des séquences d'acides nucléiques codant pour des antigènes. L'invention concerne également des nucléotides, des cellules et des méthodes associées à ces compositions, y compris leur utilisation en tant que vaccins, notamment des vecteurs et des méthodes pour une stratégie hétérologue de primovaccination/rappel. L'invention concerne également une méthode pour stimuler la réponse immunitaire chez un patient.
Patent WO-2021133644-A1 (WO)
Title: Co-agonistes triazole agrafés de récepteurs du glucagon et du glp-1
Inventor: BIANCHI ELISABETTA
IPC: C12N15/16
Filed: 2020-12-18
Abstract: Les peptides agrafés selon la présente invention, et des sels pharmaceutiquement acceptables de ceux-ci, sont des co-agonistes de récepteurs du glucagon et de GLP-1, et peuvent être utiles dans le traitement, la prévention et la suppression de maladies médiées par le récepteur du glucagon et le récepteur de GLP-1, comprenant, mais non exclusivement, des troubles métaboliques tels que le diabète, la stéatose hépatique non alcoolique (SHNA), la stéatohépatite non alcoolique (NASH) et l'obésité.
Patent WO-2021127601-A1 (WO)
Inventor: SOBINOV ANTON
IPC: A61F2/00
Filed: 2020-12-19
Abstract: L'invention concerne un système et un procédé de commande d'un dispositif, tel qu'une réalité virtuelle (VR) et/ou une prothèse de membre. Un dispositif de commande biomimétique du système comprend un processeur de signal et un modèle musculosquelettique. Le processeur de signal traite M signaux biologiques reçus d'un membre résiduel pour transformer les M signaux biologiques en N signaux d'activation, M et N étant des nombres entiers et M étant inférieur à N. Le modèle musculosquelettique transforme les N signaux d'activation en signaux de mouvement prévus. Un dispositif de commande de prothèse transforme les signaux de mouvement prévus en trois signaux de commande ou plus qui sont émis par un orifice de sortie du dispositif de commande de prothèse. Un dispositif commandé reçoit les signaux de commande et effectue une ou plusieurs tâches en fonction des signaux de commande.
Patent WO-2021138156-A1 (WO)
Title: Biofilm prevention and treatment
Inventor: ALBERT KRISTINA
IPC: A61P13/00
Filed: 2020-12-22
Abstract: A method for preventing and treating internal infections, e.g., urinary tract infections, caused by catheters is provided, in particular by reduction in catheter-associated biofilms. A coating composition is used to treat the catheter and applied through the catheter into the bladder or other body urinary tract organ to kill or neutralize microorganisms, including biofilms therein. The composition comprises a humectant and an antimicrobial with the antimicrobial including a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof. The coating layer has antimicrobial cidal or static activity for at least about one hour.
Patent WO-2021141829-A1 (WO)
Title: Actuator for package
Inventor: WELSH JAMES
IPC: B05B7/30
Filed: 2020-12-31
Abstract: A product-dispenser system includes a canister formed to include a product-storage region therein. The canister includes a canister body and a valve coupled to the canister body. The product-dispenser system further includes a cap unit that includes an adaptor fixed to the canister and a reusable actuator configured to be coupled to the adaptor.
Patent WO-2021062427-A1 (WO)
Inventor: CHEN JIANJUN
IPC: G06F16/27
Filed: 2020-04-30
Abstract: L'invention concerne un procédé mis en oeuvre par ordinateur pour effectuer une gestion de cohérence de données d'application parmi une pluralité de dispositifs informatiques à l'intérieur d'un réseau de communication, le procédé comprenant une étape consistant à récupérer par un premier dispositif des données d'application en provenance d'un second dispositif. Les données d'application comprennent un ID d'application et un premier numéro de version d'application d'une application installée sur le second dispositif. Une première table de base de données est mise à jour à l'aide d'un type d'objet associé à l'ID d'application et au premier numéro de version d'application. Le type d'objet identifie un schéma de table de base de données d'un objet de données utilisé par l'application et une pluralité de champs de données de l'objet de données. Des données stockées par un ou plusieurs de la pluralité de champs de données sont synchronisées avec un troisième dispositif en fonction d'un second numéro de version d'application de l'application installée sur le troisième dispositif et la première table de base de données.
Patent WO-2021158327-A1 (WO)
Title: High frequency silicone dampening gel
Inventor: LEE GYUYOUNG
IPC: C08G77/00
Filed: 2021-01-07
Abstract: A composition contains 45-65 weight-percent (wt%) of a linear polyorganosiloxane with terminal vinyl functionality, 39 wt% to less than 50 wt% alkenyl-free polyorganosiloxane resin comprising R 3 SiO 1/2  and SiO 4/2  siloxane units at an average molar ratio of greater than zero to 10; where R is independently in each occurrence selected from a group consisting of alkyl groups containing from one to 10 carbon atoms; 0.5-15 wt% mercapto-functional linear polyorganosiloxane crosslinker; 0.01-0.1 wt% radical stabilizer; 0.01-3 wt% thiol-ene photopolymerization initiator; 0-10 wt% fumed silica; and 0-5 wt% polydimethylsiloxane; wherein weight-percent values are relative to composition weight, the composition has a molar ratio of SiH/vinyl functional groups that is greater than 0.3 and at the same time less than 0.8 and wherein the composition is free of alkenyl functional polyorganosiloxane resin, free of alkoxysilyl containing components, and free of polysiloxane comprising R SH SiO 3/2  siloxane units, where R SH  is a mercapto-group containing hydrocarbyl.
Patent WO-2021150907-A1 (WO)
Title: Locking cargo restraint with multiple retracting cables
Inventor: QUEENER MONTY
IPC: B60P7/08
Filed: 2021-01-22
Abstract: A locking cargo restraint with multiple retracting cables is provided for securing cargo to a base, surface, or object. The locking cargo restraint is generally composed of a housing, retractable cables, and spools. The cables may be spooled within the housing to take up slack for storage of the device or to provide tension when cargo is being secured. The spools are spring biased to assist the user in pulling the cables into the housing. The cables are independently operable, allowing the operator to secure symmetrical or irregularly shaped objects. The locking cargo restraint also features a mode selection knob that can effectuate different modes of operation of the device such that the cables may be extended from the housing, retracted into the housing, or tightened about cargo. Further, the device includes a lock mechanism that, when engaged, limits the operation of the mode selection knob.
Patent WO-2021151106-A1 (WO)
Inventor: ATEFI ALI
IPC: H04W74/02
Filed: 2021-01-26
Abstract: Plusieurs aspects concernent divers appareils, divers procédés et un support lisible par ordinateur. Certains aspects concernent la communication sans fil entre divers appareils, qui peuvent comprendre un ou plusieurs points d'accès (AP) et/ou une ou plusieurs stations (STA). Le ou les AP et/ou la ou les STA peuvent comporter une ou plusieurs radios. Certains autres aspects concernent diverses caractéristiques associées à cette radio ou à ces radios. Certains aspects encore concernent certaines technologies associées à une ou plusieurs communications en liaison montante (UL) et/ou à une ou plusieurs communications en liaison descendante (DL). La description écrite et les dessins annexés fournissent des descriptions détaillées concernant ces aspects et de nombreux autres aspects.
Patent WO-2021158438-A1 (WO)
Title: Systems and methods for booting from nand flash using squashfs to maximize memory
Inventor: ANDERES WALTER H
IPC: G06F8/61
Filed: 2021-01-29
Abstract: Embodiments of the systems and methods disclosed herein includes a NAND flash memory having a boot volume. The boot volume can include a primary boot partition, a secondary boot partition, and a rootdisk partition. The primary boot partition can be configured to receive a kernel component of a file. The secondary boot partition can be configured to receive a copy of the kernel component of the file. The rootdisk partition can be configured to receive a root filesystem of the file.
Patent WO-2021162902-A1 (WO)
Title: Improved hydrocarbon production through acid placement
Inventor: OMDAL EDVARD
IPC: C09K8/80
Filed: 2021-02-03
Abstract: The invention relates to the completion of hydrocarbon wells using acid. It is known to create cavities in the formation using acid, which then collapse to leave a highly permeable region for production of hydrocarbons. An issue with this technique can be that the wellbore/tubing adjacent the cavity is damaged. The invention involves passing thin conduits through the formation transversely of the main wellbore, through which conduits acid is delivered to create unstable cavities at a distance from the main wellbore thereby stimulating production without risking instability of the main wellbore.
Patent WO-2021168283-A1 (WO)
Title: Therapeutic methods and compositions for treating cancer using braf and/or mek inhibitor combination therapy
Inventor: AUDOLY LAURENT
IPC: A61K31/50
Filed: 2021-02-19
Abstract: The invention provides methods, compositions, and medical kits for treating cancer using combination therapy including a BRAF and/or MEK inhibitor and at least one additional therapeutic agent that inhibits at least one target impacting oxidation state of the cancer.
Patent WO-2021168435-A1 (WO)
Title: Automated identification of training data candidates for perception systems
Inventor: KOOPMAN PHILIP J
IPC: G06N20/00
Filed: 2021-02-22
Abstract: Methods are described for automatically identifying perception weaknesses for training data to be used in improving the performance of perception systems. Deficiencies in simulated data are also identified. The methods, which can be incorporated into a system or into instructions placed on storage media, include comparing perception system results between baseline results and results with augmented inputs and identifying perception weaknesses responsive to that comparison. The perception system is retrained using the relabeled data and is improved thereby.
Patent WO-2022191852-A1 (WO)
Title: Variability characterization with truncated ordered sample simulation
Inventor: COOPER JAMES
IPC: G06F30/367
Filed: 2021-03-12
Abstract: A computing system implementing a design characterization tool can sample a distribution of values describing manufacturing variation for an integrated circuit described by a circuit design. The design characterization tool can utilize a set of the samples to generate a surrogate model of the circuit design, and can order another set of the samples based on predicted outputs of the surrogate model. The design characterization tool can simulate the surrogate model or the circuit design utilizing the ordered samples, and stop the simulations prior to all of the samples from the distribution having been utilized in the simulations. The design characterization tool can utilize a confidence interval stopping condition or a drought stopping condition to determine when to stop the simulations. The design characterization tool can utilize results of the simulations to characterize operational variation of the circuit design to the manufacturing variation described in the distribution of the values.
Patent WO-2021188733-A1 (WO)
Title: Lazarev reactor 1: production of films of two-dimensional polymers
Inventor: LAZAREV PAVEL IVAN
IPC: C08F10/02
Filed: 2021-03-17
Abstract: The present disclosure provides Lazarev reactor that sustains reaction of two dimensional polymerization on the interface of two immiscible solutions A and B carrying components of reaction to the interface where reaction takes place and produces film of two dimensional polymer layers that are pulled out of reactor and rolled up on roll after drying excess of solvent out.
Patent WO-2021194997-A1 (WO)
Inventor: CHAN JASON
IPC: G09B23/28
Filed: 2021-03-22
Abstract: Exemplary embodiments include systems and methods for simulating a medical procedure. The simulator may approximate a portion of the body including the vasculature for providing simulation of accessing the vasculature in the medical procedure. The simulator may therefore include any combination of pump(s), conduit(s), reservoir(s), valve(s), body material, coverings, etc.
Patent WO-2021195119-A1 (WO)
Inventor: MORAITIS ANDREAS
IPC: C12Q1/37
Filed: 2021-03-23
Abstract: Coronavirus infection is mediated by the glucocorticoid-modulated host receptor proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Glucocorticoid receptor antagonists (GRAs) may be administered to reduce ACE2 or TMPRSS2 numbers, expression and activity, and to enhance the immune response in a patient. GRA administration can be used to treat coronavirus infection. Treatments for coronavirus infections, including SARS-CoV-2 infections (COVID-19 disease), comprise administering a GRA effective to reduce ACE2 or TMPRSS2 levels, and to enhance the immune response in the patient. These methods may be combined with administration of other agents and treatments. The methods include prophylactic methods effective to reduce the risk of infection and therapeutic methods effective to reduce the severity and duration of viral infections. The GRA may be steroidal (e.g., mifepristone), and may be non-steroidal, e.g., a comprising a fused azadecalin structure; a heteroaryl-ketone fused azadecalin structure; or an octahydro fused azadecalin structure.
Patent WO-2021202253-A1 (WO)
Title: Perception-based alignment system and method for a loading machine
Inventor: BERRY JEFFREY K
IPC: E02F3/43
Filed: 2021-03-26
Abstract: A perception-based alignment system (210) can assist in aligning a loading machine (110) with a material receptacle (150). The perception-based alignment system (210) can be associated with a visual sensor network (220) that can capture an image of the material receptacle (150). A fiducial marker (224) is associated with the material receptacle (150). In an aspect, the perception-based alignment system (210) can record an alignment data record (232) of a loading operation and associate the alignment data record (232) with the fiducial marker (224) and, in another aspect, the perception-based alignment system (210) can retrieve and execute the alignment data record (232) to assist with a subsequent loading operation.
Patent WO-2021211794-A1 (WO)
Inventor: DANIEL RONALD
IPC: G06N3/04
Filed: 2021-04-15
Abstract: A system to maintain a knowledge base including a device to: (i) generate a first interface to: receive a query for transmission to a question-answer system and provide a response including one or more proposed triple in a list, (ii) after selection of a particular triple, generate a second interface to: provide at least one evidence record including a span of text in support of the particular triple, and provide one or more control element associated with each evidence record including at least one of: a first control element selectable to cite its corresponding evidence record and span of text as supporting the particular triple, or a second control element selectable to prevent its corresponding evidence record and span of text from being cited as supporting the particular triple, and (iii) generate a data structure, based on selections of the one or more control element, to update the knowledge base.
Patent WO-2021216511-A1 (WO)
Inventor: RUTBERG MICHAEL
IPC: G06T7/20
Filed: 2021-04-20
Abstract: Non-contact sensors include an image sensor configured to capture image data of a portion of a surface of a rotatable shaft and an electronic control unit communicatively coupled to the image sensor. The electronic control unit is configured to receive image data having a plurality of frames from the image sensor and store the image data in a memory component of the electronic control unit, determine a transformation in image space between one or more surface features that appear in a first frame of the image data and the same one or more surface features that appear in a second frame of the image data, determine a rotational position of the rotatable shaft at a time of capture of the second frame of the image data based on the transformation and a quantitatively characterized relationship between image space and object space, and store the rotational position of the rotatable shaft.
Patent WO-2021216780-A1 (WO)
Inventor: LADERMAN ELISABETH
IPC: G01N33/53
Filed: 2021-04-21
Abstract: The present disclosure provides a device for collecting a biological sample from a subject suspected or having a viral infection, the device comprising: a sample collection portion, comprising an absorbent pad capable of receiving a biological sample, a flexible card flap that is dimensionally suited to completely seal the sample collection portion, and a non-absorbent solid support, wherein the device is suitable for maintaining the stability of the sample.
Patent WO-2022005570-A1 (WO)
Title: Logging operations based on memory mapping in a logging system
Inventor: JOSHI DHRUV
IPC: G06F11/34
Filed: 2021-04-23
Abstract: Methods, systems, and computer storage media for providing log files using logging system operations in a logging system. The logging system operations support memory mapping log files and asynchronously managing file operations. The logging system operations support selectively mapping segments of log files during write operations. The logging operations also support performing file operations (e.g., closing, opening, deleting and serializing files) advantageously as background processes. Selective memory mapping specifically includes incrementally mapping new segments of a log file up to a predetermined log file size limit. The logging operations support processing spare files using spare file memory mapping. A spare file replaces an existing log file to continue writing logging data using the spare file. Based on the memory mapping, additional logging system operations of the logging system can be performed including persisting the log file data even when the application crashes, minimizing of forced flushes, and asynchronous file management.
Patent WO-2021217025-A1 (WO)
Inventor: OZDOGANLAR O BURAK
IPC: A61F13/38
Filed: 2021-04-23
Abstract: A device to collect a biological sample may generally include an elongated rod having a handle and terminating in a tip; and a core and a plurality of projections extending in a radial direction from a surface of the core. The projections may have curved geometric pattern, such as a sinusoidal pattern, a circular arc pattern, and/or a helical pattern, for example. The device may include a layer of fibers disposed on a surface of the projections by flocking. Method of making and using the device are also described.
Patent WO-2022231589-A1 (WO)
Inventor: WEI JISHANG
IPC: A61B5/24
Filed: 2021-04-29
Abstract: An example method includes generating, with sensors of a wearable device, a plurality of physiological measures of a user of the wearable device. The method includes processing, with an inference engine of the wearable device, the plurality of physiological measures. The method includes generating a parametric distribution with the inference engine based on the processed physiological measures, wherein the parametric distribution includes a first parameter representing a predicted value of a current mental state characteristic of the user, and a second parameter representing an uncertainty quantification for the predicted value.
Patent WO-2022231619-A1 (WO)
Title: Method and systems for storing data in a storage pool using memory semantics with applications interacting with emulated block devices
Inventor: BONO JEAN-PIERRE
IPC: G06F3/06
Filed: 2021-04-30
Abstract: A method for storing data, comprising receiving, by a file system (FS) client executing on an offload component, a first request from a translation module, wherein the translation module translated a second request that was to be performed on an emulated block device into the first request, wherein the first request is specified using file semantics, wherein the first request is associated with data, wherein the offload component is located in a hardware layer of a client application node, and wherein the translation module is located on the offload component, and processing the first request by the FS client and a memory hypervisor module, wherein the FS client and the memory hypervisor module are executing in a modified client FS container on the offload component, wherein processing the first request results in at least a portion of the data being stored in a location in a storage pool.
Patent WO-2021222881-A1 (WO)
Inventor: GROMAN BOAZ
IPC: F04B19/04
Filed: 2021-05-03
Abstract: A medical ventilator (200) comprising two pistons (104i, 104e) moving in unison with one another within respective two (a "first" and a "second") cylinders (100i, 100e). During an exhale phase of a breathing cycle, the first cylinder (100i) receives pressurized air which causes both pistons to move (upward). In the second cylinder (100e), this creates a negative pressure to extract exhaled air from a patient's lungs. During an inhale phase of the breathing cycle, a weight acting on a link (220) between the two pistons causes both pistons to move in an opposite (downward) direction, whereupon (i) the first piston delivers the pressurized air to the patient and (ii) the second piston vents the exhaled air. The second cylinder may have a larger bore or a larger stroke than the first cylinder, or may comprise multiple (a bank of) smaller cylinders.
Patent WO-2022250693-A1 (WO)
Inventor: HUANG CHIH JEN
IPC: H05K7/10
Filed: 2021-05-28
Abstract: In some examples, a connection apparatus includes a first connector assembly to engage with a second connector assembly, where the first connector assembly is included in one of a support stand and an electronic device, and the second connector assembly is included in another one of the support stand and the electronic device. The first connector assembly includes a floating connector block, an electrical contact on the floating connector block, and a biasing assembly engaged with the floating connector block to urge the floating connector block towards the second connector assembly when the second connector assembly is engaged with the first connector assembly to achieve a spring-loaded engagement of the electrical contact with an electrical contact of the second connector assembly.
Patent WO-2021243276-A1 (WO)
Title: Crispr/cas chain reaction systems and methods for amplifying the detection sensitivity of crispr-based target detection
Inventor: RANANAWARE SANTOSH R
IPC: C12N15/11
Filed: 2021-05-28
Abstract: The present disclosure provides CRISPR/Cas chain reaction (CCR) systems and methods for amplifying the detection sensitivity of a primary CRISPR-based target detection (CBTD) system for detecting targets. Also described are methods of using CCR systems to amplify the detection sensitivity of primary CBTD systems to detect a target without a target preamplification step. Multiplexed CBTD systems for detecting a target using two different Cas enzyme systems are provided.