Patent SG-11201902876T-A (SG)
Title: New antimicrobial agents against enterococcus bacteria
Inventor: BIEBL MANFRED
IPC: C12N9/36
Filed: 2017-10-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111111111111111111001111110111101111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/073416 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: A61K 38/47 (2006.01) Cl 2N 9/36 (2006.01) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (21) International Application Number: PCT/EP2017/076861 Published: — with international search report (Art. 21(3)) (22) International Filing Date: — with sequence listing part of description (Rule 5.2(a)) 20 October 2017 (20.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16194788.2 20 October 2016 (20.10.2016) EP (71) Applicant: LYSANDO AG [LI/LI]; Wangerbergstr. 91, 9497 Triesenberg (LI). (72) Inventors: BIEBL, Manfred; Am Dietlmeierhof 10, 93083 Obertraubling (DE). SCHIRMEIER, Eva; Brun- huberstr. 8, 93053 Regensburg (DE). GRIESSL, Martin; Scambachring 7, 93155 Hohenschambach (DE). (74) Agent: RUCKERL, Florian; Dehmel & Bettenhausen — Patentanwalte PartmbB, HerzogspitalstraBe 11, 80331 = Miinchen (DE). = _ (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, —= HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = — KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, — = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind ARIPO GH, = of regional protection available): (BW, _ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, _ = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, HR, HU, IE, IS, IT, LT, LU, LV, GB, GR, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = — TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = KM, ML, MR, NE, SN, TD, TG). 1-1 (54) Title: NEW ANTIMICROBIAL AGENTS AGAINST ENTEROCOCCUS BACTERIA 1-1 i v (57) : The present invention relates to the field of antimicrobial agents active against Enterococcus bacteria. In particular, the M present invention relates to a polypeptide comprising a first and a second amino acid sequence, wherein the first amino acid sequence C is a sequence selected from SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 5; and derivatives thereof; and wherein the second amino acid ---- sequence is an antimicrobial peptide, amphipathic peptide, cationic peptide, hydrophobic peptide, sushi peptide or defensin. In addition, *1 : the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding 1-1 © host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, ei in particular in the pharmaceutical field. C