Patent GB-1397624-A (GB)
Title: Composition ror oral administration for counteracting the  greasy appearance of the head of hair and or the skin
IPC: A61K31/195
Filed: 1972-04-21
Abstract: 1397624 Pharmaceutical compositions L'OREAL 21 April 1972 [23 April 1971] 34611/74 Divided out of 1397621 Heading A5B A composition suitable for oral application comprises an orally acceptable vehicle and at least one active compound corresponding to the formula: in which: 1) n is 0 or 1 such that: if n=0 R 1  and R 2  each independently represent a hydrogen atom or a methyl radical; if n=1 R 1  and R 2  each represent a hydrogen atom. 2) R 3  represents (i) an -OH radical, (ii) an alkoxy radical with 1 to 5 carbon atoms, (iii) a radical of the formula: in which y' and y" each independently represents an alkyl radical with 1 to 3 carbon atoms or, together with the nitrogen atom to which they are attached form a morpholino, piperidino, pyrrolidino or N'-methyl-piperizino radical, (iv) a -NHOH radical, 3) A is chosen from either under definition (a) in which: A represents a hydrogen atom, a nicotinoyl radical, or a radical of the formula -COR 4  or -SO 2 R 4  in which R 4  represents: (i) an alkyl radical with 1 to 6 carbon atoms, or (ii) a radical of the formula: in which R 5  represents a hydrogen atom, a methyl radical, an alkoxy radical with I to 4 carbon atoms or an acetamido radical, or under definition (b) in which A represents a -CONH 2  radical, an isonicotinoyl group, a picolinoyl group, a -COR 6  radical wherein R 6  represents: a hydrogen atom, an alkyl radical with 7 to 18 carbon atoms, an alkenyl radical with 2 to 18 carbon atoms, a radical of the formula: a radical of the formula: a radical of the formula: or a -CH 2 CH 2 COOH radical, or a radical of the formula: wherein R 7  represents an alkyl radical with 2 to 4 carbon atoms or a halogen atom 4) t is 1 or 2 such that: if t=1, R is chosen from: either under definition (a) in which R represents:- -C(C 6 H 5 ) 3 , -CH(C 6 H 5 ) 2 , -(CH 2 ) 8  COR 7  in which s is from I to 4, and R 7  represents either -OH or an alkoxy radical with 1 to 5 carbon atoms; or under definition (b) in which R represents: (i) a linear or branched alkyl radical with 1 to 18 carbon atoms, (ii) an alkenyl radical with 3 to 18 carbon atoms, (iii) an alkyl radical with 2 to 4 carbon atoms substituted by 1 to 2 hydroxy radicals, (iv) a radical of the formula: in which R 3  is as defined above and A 1  is as defined under A, (v) a radical of the formula: -CH 2 -CH 2 -NH A 1  in which A 1  is as defined above, (vi) a radical of the formula: (vii) a radical of the formula: in which m is 1 or 2, R"' represents an alkyl radical with 1 to 4 carbon atoms and B represents a divalent radical: (viii) a radical of the formula: -(CH 2 ) p -R 9 , in which p is 0, 1 or 2 such that if p=0, R 9  represents either a 1-naphthyl or a 2-naphthyl radical; if p=1, R 9  represents a 1-naphthyl or 2-naphthyl radical, a 2-thienyl radical, a 2-tetrahydrofuryl radical, a 2-furyl radical or a 2-pyridyl-N-oxide radical; and, in addition, if p=0, 1 or 2, R 9  represents a 2-pyridyl radical (ix) a radical of the formula: in which q is 1, 2 or 3, x is 0 or 1, and R 12  represents a halogen atom, a hydrogen atom, an alkoxy radical with 1 to 5 carbon atoms or a branched or unbranched alkyl radical with 1 to 4 carbon atoms, such that, in addition, if q is 1, R 12  represents a dialkylamino radical, the alkyl groups having 1 to 5 carbon atoms, an amino radical, a phenoxy radical, a cyclohexyl radical, an acetamido radical, a methylenedioxy radical, a nitro radical, a phenyl radical or a trifluoromethyl radical with the proviso that R 12  does not represent a hydrogen atom if x is 1; (x) a radical of the formula: -CH 2 -CH 2 -C 6 H 5  (xi) a radical of the formula: -CH(C 6 H 4p -OCH 3 ) 2  (xii) a radical of the formula: -C(CH 3 ) 2 C 6 H 4p -OCH 3  (xiii) a radical of the formula: -(CH 2 ) z COR 10  in which z represents an integer from 1 to 5 and R 10  represents a glucosamine radical, a -N(CH 2 CH 2 OH) 2  radical or a radical of the formula: wherein y' and y" are as defined above; if t=2, R represents an alkylene radical with 2 to 4 carbon atoms or an alkylene radical substituted by 1 or 2 OH radicals, or a butenylene radical or a radical of the formula: -(CH 2 ) 2 -SO 2 -(CH 2 ) 2 - with the proviso that if t=1 and n=0 at least one of the radicals A and R is defined under a definition (b) except that when A represents a hydrogen atom R may be a radical of the formula: in which R 8  represents a halogen atom or an alkoxy radical, or an acid addition salt thereof.