baber/WOPTO huggingface dataset:
Patent AU-2021318589-B2 (AU)
Title: Use of CD44 antibody in preparation of medicine for treating Parkinson's disease
Inventor: SUN CHENG
IPC: A61K39/395
Filed: 2021-09-05
Granted: 2022-06-02
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(54) Title: USE OF CD44 ANTIBODY IN PREPARATION OF MEDICINE FOR TREATING PARKINSON'S DISEASE 
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(57) Abstract: Provided is use of a CD44 antibody in preparation of a med
A BB DD icine for treating Parkinson's disease (PD). By means of a stereotactic injec
tion method, the CD44 antibody (anti-CD44) is injected into the cortex part of 
AA x EE Parkinson's disease model mice, and it is found that the antibody can signif
cc icantly alleviate PD-related symptoms, such as improve the movement func
B Mig FF C 2% GG tions of the mice, restore the number of dopaminergic neurons in the substan
tia nigra part and inhibit neuroinflammation.  
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BB Behavioral training 
CC MPTP mo eling 
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EE Morphology and protein testing 
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Patent AU-2022203856-B2 (AU)
Title: High gain and large bandwidth antenna incorporating a built-in differential feeding scheme
Inventor: TEHRAN HAMID REZA MEMAR ZADEH
IPC: H01Q9/04
Filed: 2022-06-03
Granted: 2023-07-06
Abstract: ] 
The present disclosure relates to a communication method and system for 
converging a 5th-Generation (5G) communication system for supporting higher data 
rates beyond a 4th-Generation (4G) system with a technology for Internet of Things 
5 (IoT). The present disclosure may be applied to intelligent services based on the 5G 
communication technology and the IoT-related technology, such as smart home, smart 
building, smart city, smart car, connected car, health care, digital education, smart 
retail, security and safety services. An antenna and a base station including the antenna.  
The antenna includes a sub-array that includes first and second unit cells and a feed 
0 network. The first and second unit cells comprise first and second patches, respectively, 
having quadrilateral shapes. The feed network comprises a first transmission line 
terminating below first corners of the first and second patches, respectively; a second 
transmission line terminating below third corners of the first and second patches, 
respectively; a third transmission line terminating below a second corner of the first 
5 patch and a fourth corner of the second patch; and a fourth transmission line 
terminating below a fourth corner of the first patch and a second corner of the second 
patch. The first corners are opposite the third corners on the respective first and 
second patches and the second corners are opposite the fourth corners on the 
respective first and second patches.  
20 
18775025_1 (GHMatters) P115044.AU.1
Patent JP-3991300-B2 (JP)
IPC: H01L21/762
Filed: 2000-04-28
Granted: 2007-10-17
Abstract: The present invention provides a method for producing a bonded dielectric separation wafer in which an auto-alignment can be carried out with reference to the orientation flat of a supporting substrate wafer after the wafer bonding step, and also an apparatus to be used for bonding wafers. When wafers are placed one upon another, the silicon wafers 10, 20 are irradiated with transmission light in order to capture the transmission images thereof. The positions of the pattern of dielectric isolation grooves 13 in the silicon wafer 10 and the orientation flat 20a of the silicon wafer 20 are determined from the images and the bonding position of the wafers 10, 20 is determined based on the determined positions. Auto-alignment of the bonded dielectric separation wafer can thereby be carried out with reference to the orientation flat 20a of the silicon wafer 20 after the wafer bonding step. <IMAGE>
Patent JP-3631944-B2 (JP)
IPC: A61C19/04
Filed: 2000-06-22
Granted: 2005-03-23
Abstract: The display (32) shows the diagram of a tooth, with several fields. Further such diagrams may be shown. Preferred features: The diagram is divided into several fields distributed over several teeth. There is especially a field for each tooth. Fields correspond with tooth locations for which the relevant program is suited. Fields in the tooth diagram symbolize indicative locations. Additional fields of the display (32) indicate the mode of unit (10) operation, especially as an abbreviation. Additional fields can be used repeatedly, especially to show the type of operation. The unit has single-button (18) operation. The button is operated sequentially to show different types of operation, each symbolized by additional fields. In a similar arrangement, the unit is also switched on using the button. The dental unit is constructed for light-hardening of dental polymers. It is especially a hand unit, with relevant program(s) for the light-hardening operation. A field of the tooth diagram can be activated by the program, to given an indication of the relevant program. Additional numerical fields display hardening time and/or remaining hardening time. At least one display field shows light intensity as a bar display. The display section is mounted on a rearward sloping surface (30) of the hand unit, to be in the dentist's field of vision during treatment. Pulsed operation is signaled by a flashing display field.
Patent JP-4723722-B2 (JP)
IPC: A61K39/39
Filed: 1998-07-23
Granted: 2011-07-13
Abstract: The present invention concerns a use of a MHC class II ligand, such as CD4 and LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune response, as well as the use of LAG-3 in cancer-immunotherapy. The invention also concerns a pharmaceutical composition comprising an effective amount of an antigen able to induce an antigen-specific immune response together with an effective amount of MHC class II ligand wherein said MHC class II ligand is present as an adjuvant-like agent.
Patent JP-3390741-B2 (JP)
IPC: C07D239/94
Filed: 1999-01-08
Granted: 2003-03-31
Abstract: Compounds of formula (I) and salts or solvates thereof are disclosed <CHEM> wherein Y is CR<1> and V is N; or Y is CR<1> and V is CR<2>; R<1> represents CH3SO2CH2CH2NHCH2-Ar-, wherein Ar is furan or thiazole, each of which may optionally be substituted by one or two halo, C1-4 alkyl or C1-4 alkoxy groups; R<2> is hydrogen C1-4 alkoxy or halo; R<3> is benzyl, halo-, dihalo- or trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- or trihalobenzyloxy or benzenesulphonyl; R<4> is halo or C1-4 alkoxy or is not present; and wherein either (a) R<3> represents 3-fluorobenzyloxy; and/or (b) R<4> is halo and is substituted in the 3-position of the phenyl ring; and wherein halo represents fluoro, chloro or bromo. <??>Processes for the preparation of the compounds, pharmaceutical formulations of the compounds, the use of the compounds in therapy, and methods of treatment of inter alia cancer and malignant tumours by administration of the compounds is also disclosed.
Patent JP-4397122-B2 (JP)
IPC: G01N33/60
Filed: 1999-04-13
Granted: 2010-01-13
Abstract: The present invention provides a method for screening substances that promote oligomerization of receptor protein molecules or peptide fragments thereof, which comprises determining whether the receptor protein molecules or peptide fragments thereof are oligomerized when contacted with a test substance; a test kit for screening substances that promote the oligomerization of the receptor protein molecules or peptide fragments thereof, which comprises the receptor protein molecules or peptide fragments thereof and a buffer, and a substance identified by the above method, which promotes the oligomerization of the receptor protein molecules or peptide fragments thereof.
Patent JP-4153166-B2 (JP)
IPC: F04B43/00
Filed: 1999-05-22
Granted: 2008-09-17
Abstract: The invention relates to a diaphragm pump with a device for controlling the position of a diaphragm separating the conveying chamber from the displacement chamber. As a replacement of the mechanical control of the refilling process, a pressure sensor is arranged in the displacement chamber, which is connected with an evaluation unit designed for generating a refill signal, which is switched so it actuates a refill valve through an operative connection. Advantageously, a second sensor for detecting the piston travel is provided, whose signal is linked with the signal from the pressure sensor. The invention furthermore relates to a method for controlling the position of a diaphragm.
Patent JP-4668421-B2 (JP)
IPC: A61B5/0245
Filed: 2000-02-11
Granted: 2011-04-13
Abstract: A method for obtaining continuously and non-invasively one or more parameters relating to the cardiovascular system of a subject. The parameters obtainable by the method are systolic blood pressure, diastolic blood pressure, young modulus of an artery, cardiac output, relative changes in vascular resistance, and relative changes in vascular compliance. In accordance with the method, the ratio,  kappa  of the subject's blood flow velocity to the propagation speed of the subject's pulse wave is obtained continuously and non-invasively.  kappa  is then processed so as to obtain the instantaneous values of the desired parameters.
Patent JP-5046437-B2 (JP)
IPC: C01C1/04
Filed: 2001-02-07
Granted: 2012-10-10
Abstract: Process and reactor for the preparation of ammonia at elevated pressure and temperature in an ammonia reactor, wherein a process stream of ammonia synthesis gas is successively passed through at least three catalyst beds with intermediate cooling of partially reacted synthesis gas leaving the catalyst beds by heat exchange in heat exchangers arranged between each catalyst bed. The process stream is obtained by combining prior to introduction into a first catalyst bed, a first feed stream of synthesis gas having been preheated through indirect heat exchange during the intermediate cooling of the partially converted synthesis gas and a second feed stream of synthesis gas for adjustment of temperature of the process stream. The first feed stream is passed successively through the interbed heat exchangers for cooling the partially converted synthesis gas and space velocity of the synthesis gas is adjusted to be substantially in the same range in all catalyst beds.
Patent JP-3764084-B2 (JP)
IPC: A01N1/02
Filed: 2001-10-24
Granted: 2006-04-05
Abstract: An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solution movement, and structure to heat the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.
Patent JP-3907165-B2 (JP)
IPC: H01L21/027
Filed: 2001-11-05
Granted: 2007-04-18
Abstract: PROBLEM TO BE SOLVED: To provide a positive resist composition in which the change rate in line width due to the change in the film thickness of a resist on a highly reflective substrate having a rough surface is significantly suppressed. SOLUTION: The positive resist composition is characterized in containing (A) a resin which has a structural unit containing an acid-decomposing group having a specified structure and which is decomposed by the effect of an acid to increase the solubility with an alkali developing solution and/or (B) a resin which has a structural unit containing an acid-decomposing group having another specified structure and which is decomposed by the effect of an acid to increase the solubility with an alkali developing solution, a compound which generates an acid by irradiation of active rays or radiation, and a specified vinylether compound.
Patent JP-4907815-B2 (JP)
IPC: H01L29/792
Filed: 2000-10-16
Granted: 2012-04-04
Abstract: A process for fabricating an ONO floating-gate electrode in a two-bit EEPROM device includes the formation of a top oxide layer using a high-temperature-oxide (HTO) deposition process in which the HTO process is carried out at a temperature of about 700 to about 800° C. by either an LPCVD or RTCVD deposition processor. The process further includes the sequential formation of a silicon nitride layer and a top oxide layer using an in-situ LPCVD or RTCVD deposition process in which the silicon nitride layer is not exposed to ambient atmosphere prior to the formation of the top oxide layer. The formation of the top oxide layer using an HTO deposition process provides an improved two-bit EEPROM memory device by reducing charge leakage in the ONO floating-gate electrode.
Patent JP-4953540-B2 (JP)
IPC: A61B17/00
Filed: 2001-02-26
Granted: 2012-06-13
Abstract: A tissue closure device has an elongate body with a first portion and a second portion. A wound closure member is also provided. In operation, a wound closure member is releasably held on a distal end of the first portion. The wound closure member is advanced within the patient until it is placed on top of and over a wound in tissue. Flowable adhesive is injected through a lume of the second portion onto the wound closure member and tissue surrounding the wound closure member. The wound closure member applicator holds the wound closure member in place, allowing the adhesive to at least partially set. The applicator is then removed from the wound closure member. Thus, an adhesive wound closure member is attached to close an opening in tissue.
Patent JP-4909483-B2 (JP)
IPC: G01R29/08
Filed: 2001-04-05
Granted: 2012-04-04
Abstract: A testing device for measuring radiation, immunity and electromagnetic characteristics of an object to be tested (1), includes a conductive structure (53) enclosing a testing volume where the object can be placed, the structure being provided with an opening (56) capable of being closed. The testing device further includes a set of internal conductors called septa (52), at least two in number, each septum defining in the testing volume, by its configuration in the structure, an electromagnetic coupling with the object; at least a septum is arranged in such a way that its electromagnetic plane is separate and not parallel to the electromagnetic plane of at least another septum.
Patent JP-4116309-B2 (JP)
IPC: H01G11/42
Filed: 2002-03-20
Granted: 2008-07-09
Abstract: <P>PROBLEM TO BE SOLVED: To provide an electrolyte for an electrochemical capacitor which hardly deteriorates a sealing performance of a sealer and improves withstand voltage of the electrochemical capacitor.  <P>SOLUTION: An electrochemical capacitor electrolyte is composed of an electrolyte (A) consisting of an amidinium cation (a1) and an anion (a2), and a mixed solvent (B) consisting of a carboxylate (b1) and another non-aqueous solvent (b2).  <P>COPYRIGHT: (C)2003,JPO
Patent JP-3746458-B2 (JP)
IPC: B29C51/08
Filed: 2002-03-28
Granted: 2006-02-15
Abstract: A process of manufacturing a thermoforming mould with an interior vacuum chamber which includes forming an impression of the mould in a casting media, suspending a vacuum line or vacuum cabinet within the impression and pouring molten material around the vacuum line or vacuum cabinet to form the mould at least partially surrounding the vacuum line or vacuum cabinet. Vacuum holes are drilled through the mould from the mould face to the vacuum chamber. <??>Such a mould (108) with an internal vacuum chamber (111) can be used in a thermoforming apparatus comprising a quench for cooling a thermoplastic sheet 104 while it remains on the mould. Because the quench cools the sheet, conventional cooling lines are eliminated from the mould. <IMAGE>
Patent JP-4170009-B2 (JP)
IPC: H01L21/02
Filed: 2002-03-29
Granted: 2008-10-22
Abstract: <P>PROBLEM TO BE SOLVED: To solve the problem that some wafers have identification marks on a front face while others have them on a rear face and all the wafers are mixed up together, and moreover, since a read apparatus is fixed in a loader chamber, an operator has to manually change a way in which an OCR is installed in conformity with a face attached with the identification mark to make the identification mark readable by the OCR.  <P>SOLUTION: The read apparatus 10 is provided with the OCR 11 for reading a bar code BC and a motor 14 for inverting the OCR 11 in conformity with the front face or rear face of a wafer W which is attached with the bar code BC. Whether the OCR 11 is inverted or not is detected by a photomicrosensor 15 and a shutter 16.  <P>COPYRIGHT: (C)2004,JPO
Patent JP-3946592-B2 (JP)
IPC: B41J29/00
Filed: 2002-07-18
Granted: 2007-07-18
Abstract: Provided are a user interfacing display apparatus having improved operability without confusing the user as to setting displayed on a pop-up screen, and an image forming apparatus. When a copy ratio key as a detail setting key is selected on an LCD as a display section provided in the user interfacing display apparatus mounted on an image forming apparatus, the pop-up screen is displayed. At the same time, a display state of an interruption key is changed, so as to be displayed to inform that the interruption key is unavailable. While the pop-up screen is being displayed, a user is not allowed to select the interruption key. Thus, for example, on contrary to a case where process is switched to an interruption mode while the pop-up screen is being displayed, there will be no confusion as to the detail setting displayed on the pop-up screen before switching to the interruption mode.
Patent JP-4079770-B2 (JP)
IPC: H04M11/00
Filed: 2001-06-19
Granted: 2008-04-23
Abstract: The invention relates to a method for processing and transmitting digital data in a mobile telephone network, particularly using the GSM standard, and more particularly for applications using the so-called SIM Toolkit standard stores in a smart card of the so-called SIM Type of a unit of mobile equipment ( 1 ). According to the method, so-called master applications (30M) are remoted to a remote server ( 3 ) with which the mobile equipment ( 1 ) communicates. These applications (30M) communicate with the SIM smart card ( 2 ) via the circuits of the mobile equipment ( 10 ) and first and second types of so-called "reporter" SIM Toolkit applications, respectively called "reporter" ( 21 ) and "slave" ( 22 ). The invention also concerns an embedded microchip system, particularly a smart card of the so-called SIM type.
Patent JP-4191478-B2 (JP)
IPC: A61B10/02
Filed: 2001-06-14
Granted: 2008-12-03
Abstract: A single-use biopsy instrument for mounting at a multiple-use biopsy apparatus, comprises a cartridge enclosing proximal end portions of a canula, a finger tube slidingly disposed on the canula, and a stylet slidingly disposed in the canula. The canula and the finger tube have proximal holding portions and are displaceable in regard of the cartridge by displacement means disposed in the biopsy apparatus engaging with the holding portions through one or several engagement openings in one wall of the cartridge. Also disclosed is a corresponding biopsy apparatus.
Patent JP-4615186-B2 (JP)
IPC: A62B9/00
Filed: 2001-02-07
Granted: 2011-01-19
Abstract: The present invention relates to a fan-forced positive pressure breathing apparatus commonly known as a Powered Air Purifying Respirators (PAPR) system, and specifically concerns the connecting of the breathing components of such equipment. The invention is a method and apparatus for rapid engagement of PAPR breathing components (such as air supply lines and filter elements to a blower housing). The invention also provides for indicating and/or monitoring whether the relative components have been aligned and coupled in sealed engagement.
Patent JP-3771218-B2 (JP)
IPC: A61K48/00
Filed: 2001-07-06
Granted: 2006-04-26
Abstract: The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.
Patent JP-4601249-B2 (JP)
IPC: A61P43/00
Filed: 2001-11-02
Granted: 2010-12-22
Abstract: The present invention provides a peptide derivative of formula (I) wherein X is -CHOH- or -CO-; R<SUP>1 </SUP>and R<SUP>2 </SUP>are hydrogen or substituted oxycarbonyl; R<SUP>3 </SUP>is substituted oxycarbonyl; R<SUP>4 </SUP>is hydroxyl, lower alkoxy, optionally substituted piperazinyl or the like; R<SUP>5 </SUP>is a R-group side chain of an alpha-amino acid optionally protected by a protective group, R<SUP>6 </SUP>is hydroxyl, lower alkoxy or the like; m is 0 or 1; and n is an integer of 2 to 6; or a pharmaceutically acceptable salt thereof. The present invention further provides a production process and use thereof.