Patent SG-11201908893U-A (SG)
Title: Signature-hash for multi-sequence files
Inventor: SANBORN JOHN ZACHARY
IPC: C12Q1/6888
Filed: 2018-03-28
Abstract: e229ap014319EESKS1911919E£1,9199 , 9123: • 851 , 9189121991..12292.3, : 01E12111119992 :•• 212919121 , 009•59931010i2A2,3,1;;; 11201H.1681E1196F11991E...WEI , • . 11111009919A91211.EF1.AinatiVX29 40,49 , E.1991.91.1.2910982F.19129 . 18£12/0 , , •51F.4119.4...: 3b,0b9h.2122:3s. lelf)e 51 mmiter§ .7040.M.80-9416.50.100 • : : : MILE 21.11494R:111•21,3S.11.1.1•19.1 :261. •IEEEEZ 219341 191/.3.11:: IOW • • •0911111a919EF.P , 9115E99M , 22:00.8: 1.1.10142.92/.1M18061G1193.11F • 19101081.11E29103.13078221.1112181.1:19F8181.6111.121: .1.1119.SEEIE81122212 • 9P.3/4.12171rtlif IF119.94.3E1DBE211111.121Af.£112142112512293.919 133f 42100,300=050000201110.30..000.001111.•94141121119110.9F1991a, . , 19 A.2, , ,Z1211212202103A291126611W1191 , 1021SRAE: 8600291 1E012 il<101.A1OPS11.1 22 ..... 611RZAtilla1:504119399091A2a9603318213222224, F?Fi..9111.1311FEADEM12.2.922211.61.132.16 7,1.11.1.9111121.1.A12993FEIAir 101199E2112999SP 120 122 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT oimiolollm °nolo mol imam ono OII IIII (10) International Publication Number WO 2018/183493 Al (51) International Patent Classification: GOOF 19/22 (2011.01) C12Q 1/6888 (2018.01) GOOF 19/18 (2011.01) (21) International Application Number: PCT/US2018/024838 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/478,531 29 March 2017 (29.03.2017) US (71) Applicant: NANTOMICS, LLC [US/US]; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (72) Inventors: SANBORN, John Zachary; 9920 Jefferson Boulevard, Culver City, California 90232 (US). BENZ, Stephen Charles; 9920 Jefferson Boulevard, Culver City, California 90232 (US). PARULKAR, Rahul; 9920 Jeffer- son Boulevard, Culver City, California 90232 (US). (74) Agent: FESSENMAIER, Martin et al.; UMBERG ZIPSER LLP, 1920 Main Street, Suite 750, Irvine, Califor- nia 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: SIGNATURE-HASH FOR MULTI-SEQUENCE FILES 130 1-1 co 00 O C ..2.= •1WS911S11,_ . .16.301 , 11911297. 9LillA1402190RF1/81,1 ... • 12469891219919211% • .58921.“121ADITII,V12- .. ;;;. i•OFRA711 , 91 . 11F112EFAA121 IMEKkI , J.9829181191-51... • 123 EFAle1193n192MF01819.C... J420,1$E \"*.114.10.11020AESLANMEIAAOSIAEE31632FA.48xMlek._:_, i 110.3101220FERF1.911819111M8.92321A001.0 SICAE9N1103641A1.1F.1.1.RE... 11227711023E110.EIM11101 • • • • . • • • • +111111` .1133322. i111111WW1011112111111E11 !101111111' 2111111..1110111211111W```` • • • :MI I lz •2111222223.1190311131121331311311::0. ill111.1.110.1.11:211111.22 ... • 1211181 111111121111111105 . ...\" ,. • , 11319\",..611191111000111122111150 . ::1132 L111 .....11.12! ..311991191.1211100:.: ....... : .. 111......1112•12 1.1.123.11.3.1.212.0.132 iC003.81.111.3.3.1 .1M1 . ,.1.1.1.111.102111 .1.21.1.1.0.1101 • Ini1112111121111011..1 UMW. .. .1.1111111111112r • • ..,10111111111111411. 104 -, 111 t121111111111111111111 '11111111 .11000113311 '13Z0.111111111181 I IWI , EamYeiiinn 111211.111E11MM 1330 . 11121A11,0991 • '11.22€12 • 1,1111122112102 ...MAW '1E111 ' 1.9.1111111... . ‘ ..1.1.1.111%. 9 1 ' 'n1110121:11 1 ,1210.111111:111 111111`• 11111= .. ..'..;111 .31211 .00.100 ,, Di1.10•31M , EFFFFIEM£3330MEEEFEIF012322.i112.1E21401,: MEMS142.343E111.1.2ENTEYMPF12111112.11120,2 11 , 113.£ , MIMEFIN Figure 1 (57) : A unique hash representing patient omics data is constructed using results for known SNP positions and their respective allele frequencies in the patient's omics data. In most preferred aspects, the known SNP positions are selected for specific factors (e.g., ethnicity, sex, etc.) and the allele fraction is represented in values of a non-linear scale. Typically, the hash comprises a header/metadata relating to the known SNP positions and non-linear scale and further includes the actual hash string. [Continued on next page] WO 2018/183493 Al MIDEDIMOIMEMIHINOMOINIIIMIBIMMOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1))