baber/WOPTO huggingface dataset:
Patent EP-4096782-A1 (EP)
Inventor: XU ZHEN
IPC: A61P35/04
Filed: 2021-01-28
Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.
Patent EP-4182121-A1 (EP)
Inventor: TREVISAN PIERGIORGIO
IPC: B24D5/06
Filed: 2021-06-28
Abstract: Described is a tool-holder cylinder (100; 300) for supporting abrasive tools, designed to be attached to a head (71 ) of a machine tool for surface machining of ceramic and/or stone materials, wherein said head (71 ) is configured to rotate about a first axis (x) substantially parallel to a surface to be machined and coinciding with the axis of central symmetry of said cylinder (100; 300), said cylinder (100; 300) comprising an upper surface (120; 320), a lower surface (130; 330), and a side surface (160; 360) parallel to the first axis (x) and on which are formed a plurality of seats (111; 311 ) designed to house said abrasive tools by means of a dovetail coupling, characterised in that said seats (111; 311 ) have a first tapering which extends perpendicularly and away from the first axis (x), and a second tapering parallel to the first axis (x). The invention further relates to an abrasive unit comprising a cylinder of the said type and to a machine comprising said abrasive unit.
Patent EP-4171719-A1 (EP)
Title: Medical stopcock assembly with position detection
Inventor: PICOT JOHN
IPC: A61M39/22
Filed: 2021-06-29
Abstract: A medical stopcock assembly with position detection includes a medical stopcock and a sensor. The medical stopcock may include a main body and a valve body. The valve body may define a valve passageway and be moveable relative to the main body between a first position where a first input port and an output port are in fluid communication via the valve passageway, a second position where a second input port and the output port are in fluid communication via the valve passageway, and a third position where the second input port and the first input port are in fluid communication via the valve passageway. An external surface of the valve body may include a position structure. The sensor may be configured to sense the position structure to determine whether the valve body is in the first position, the second position, or the third position.
Patent EP-4106620-A1 (EP)
Inventor: ADLER MARK A
IPC: A61B5/02
Filed: 2021-02-17
Abstract: A system that provides an independent and agnostic cardiovascular sensing ability that can be deployed prior to the standard treatment methods for blocked cardiovascular arteries, and placed in the zone of a vascular lesion for treatment, placing sensors that can monitor blood and vessel specificity to manage the acute and long term biologic reaction to the treatment zone communicating information for analytical management and decision processing to an external or internal receiving station.
Patent EP-4192952-A1 (EP)
Inventor: BAO YI
IPC: A61K31/7088
Filed: 2021-08-09
Abstract: L'invention concerne des procédés de traitement ou de soulagement d'une maladie ou d'une affection dégénérative de la rétine chez un sujet en ayant besoin. Dans certains modes de réalisation décrits ici, les procédés comprennent l'administration au sujet d'une quantité thérapeutiquement efficace d'un inhibiteur de gène I inductible par l'acide rétinoïque (RIG-I).
Patent EP-4197258-A1 (EP)
Title: Incremental signaling method for cross-slot scheduling and bursty traffic
Inventor: KARANUKARAN PRASANTH
IPC: H04W72/04
Filed: 2021-08-16
Abstract: Embodiments provide a transceiver [e.g., UE] of a wireless communication system, wherein the transceiver is configured to receive a first control message [e.g., in a first slot or subframe, such as slot or subframe n] [e.g., comprising a first control information or control configuration], wherein the transceiver is configured to receive a second control message [e.g., in a second slot or subframe, such as slot or subframe n+koff-Δ] [e.g., comprising a second control information or control configuration], wherein the second control message is linked [e.g., refers] to the first control message by an identifier, ID [e.g., DCI/base grant ID], or indication, wherein one out of the first control message, the first control message and the second control message together, the second control message, grant or assign a resource to the transceiver for a communication of the transceiver.
Patent EP-4110922-A1 (EP)
Title: Methods and compositions for targeting pd-l1
Inventor: BEIGELMAN LEONID
IPC: A61P35/00
Filed: 2021-02-25
Abstract: The present disclosure relates to small interfering RNA (siRNA) molecules directed to mRNA transcripts of CD274 to cause downregulation of programmed death-ligand 1 (PD-L1) expression in humans. The siRNA can be constructed of unmodified nucleotides or modified nucleotides that exhibit modified sugars, nucleobases, linkages, or covalently bound targeting moieties. Also disclosed herein are pharmaceutical compositions of siRNAs and uses of or methods of using the siRNAs for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.
Patent EP-4116266-A1 (EP)
Title: System for purifying a liquid
Inventor: SHMIDT JOSEPH L
IPC: C02F1/44
Filed: 2021-02-03
Abstract: The invention relates to liquid purification systems with purified water mineralization, which uses predominantly water from various resources. 
     The main problem of existing liquid purification systems, particularly membrane systems, is that during the purification process not only dangerous debris (residual oil, pesticides, herbicides, heavy metals, bacteria, viruses, mechanical particles and other) are removed, but even the minerals necessary for human (calcium, potassium, magnesium, sodium and other), so a mineralization step is needed after the purification step to normalize mineral composition. In the state of the art, there are known liquid purification systems with integral mineralization means and also devices for mineralization which can be connected to liquid purification systems. The working principle of the systems known in the state of the art is that purified liquid flows through a vessel with mineralization additive, which is partly dissolved and the liquid becomes mineralized. The main drawback of the systems known in the state of the art is that due to peculiarities of the dissolving process and/or mineralization additive content, it is impossible to control the mineralization process, so the mineralization level is minor, and the pH is higher than the permitted value. 
     The liquid purification system contains a raw liquid line, a liquid purification unit, a mineralization unit, a purified liquid line is characterized in that mineralization of liquid is performed by controlled dispensing of a mineralization solution obtained by selective purification of raw or drainage liquids, or a mixture thereof.
Patent EP-4114463-A1 (EP)
Inventor: CAMPBELL JOHN D
IPC: A61K39/215
Filed: 2021-03-01
Abstract: The present disclosure relates to immunogenic compositions comprising a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen, and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against a SARS-CoV-2 in an individual in need thereof.
Patent EP-4118156-A1 (EP)
Title: A composite coating for increasing atmospheric condensation on a surface of a substrate
Inventor: NETO CHIARA
IPC: C09D5/02
Filed: 2021-03-12
Abstract: Composite coatings that passively cool when exposed to the sky are provided. The composite coatings are suitable for increasing atmospheric condensation on a surface of a substrate. In particular, the composite coatings may be suitable for capturing atmospheric water. Also provided are methods for producing the composites coatings, methods for coating the surface of substrates with the composite coatings, methods for condensing and collecting atmospheric water, and systems for collecting condensed atmospheric water.
Patent EP-4118268-A1 (EP)
Title: Système de passage de poissons pour barrages à haute et moyenne hauteur
Inventor: OBERMEYER HENRY K
IPC: A01K79/00
Filed: 2021-03-12
Abstract: La présente invention concerne un système de passage de poisson destiné à être utilisé dans des barrages. Il peut incorporer une ou plusieurs turbines à pompe réversibles pour commander et générer de l'énergie à partir d'un écoulement en aval d'eau et de poissons et pour pomper de l'eau et des poissons en amont. Pour des modes de réalisation à basse pression, le système peut utiliser de l'eau stockée au-dessus de l'élévation de l'eau de tête au lieu d'une turbine de pompe réversible pour déplacer le poisson et l'eau à partir de l'eau de fond vers l'eau de tête.
Patent EP-4189244-A1 (EP)
Inventor: SCHNITTGER THORSTEN
IPC: F04C2/107
Filed: 2021-08-27
Abstract: The invention relates to a method for operating a conveyor (1) having an eccentric screw pump (2) for conveying viscous construction materials (BM).
Patent EP-4134293-A1 (EP)
Inventor: HASHIMOTO NAOKI
IPC: E01B35/00
Filed: 2021-03-30
Abstract: A maintenance apparatus (10) transmits a pulse signal from a predetermined observation point (P) of rails (R), observes an observation signal that appears at the observation point (P) after transmission of the pulse signal, compares an observation history of the observation signals and the observation signal received this time, and detects occurrence of abnormality in any one of the rails (R) and at least one electric apparatus (20) connected to the rails (R).
Patent EP-4113875-A1 (EP)
Inventor: ZHENG JUAN
IPC: H04W72/04
Filed: 2021-04-08
Abstract: Embodiments of this application provide a control information transmission method, an apparatus, and a system, relate to the field of communication technologies, and can resolve a technical problem that when a terminal device performs bandwidth part BWP switching, a large quantity of downlink control information DCI formats are detected, detection complexity is high, and power consumption is high, which is not helpful in power saving. The method includes: A first terminal device receives, from a network device, DCI used for indicating a BWP. A quantity of bits in the DCI is a fixed quantity of bits. The DCI is used for scheduling a physical data channel. The BWP is used to transmit the physical data channel.
Patent EP-4138035-A1 (EP)
Inventor: YAMAMOTO SHUHEI
IPC: G06T7/00
Filed: 2021-02-03
Abstract: Disclosed is a cell image analysis device 2 including: a display unit 52; a storage unit 31 which stores learning data which is a set of data of a cell image and data of an analyzed image in which a region of interest included in the cell image is specified, and a discriminator which is created using a learning model constructed by machine learning using the learning data; a test data input receiver 36 configured to receive an input of test data; a discriminator evaluation unit 37 configured to evaluate the discriminator using the test data; an evaluation result storing unit 38 configured to store evaluation data including an evaluation result of the discriminator and the test data used for the evaluation in association with the discriminator; and a display processor 39 configured to display the test data and/or the evaluation result associated with the discriminator on a screen of the display unit in response to an input for selecting the discriminator.
Patent EP-4142862-A1 (EP)
Inventor: TELFEIAN ALBERT
IPC: A61N1/02
Filed: 2021-04-28
Abstract: La présente invention divulgue un réseau d'électrodes comprenant une gaine externe amovible, une couche d'isolation, la gaine externe entourant la couche d'isolation, et une lumière centrale entourée de la couche d'isolation, la lumière centrale comprenant un alliage métallique de nickel et de titane ou un polymère thermodurci à mémoire de forme. Le réseau est utilisé dans le cadre de la stimulation et de l'enregistrement à effraction minimale de la moelle épinière et du cerveau.
Patent EP-4147228-A1 (EP)
Inventor: SHARMA DUSHYANT
IPC: G10L15/20
Filed: 2021-05-10
Abstract: L'invention concerne un procédé, un produit-programme d'ordinateur et un système informatique permettant de recevoir une pluralité de faisceaux prédéfinis associés à un réseau de microphones. Une pluralité de valeurs nulles prédéfinies associées au réseau de microphones peuvent être reçues. Un ou plusieurs faisceaux prédéfinis parmi la pluralité de faisceaux prédéfinis ou une ou plusieurs valeurs nulles prédéfinies parmi la pluralité de valeurs nulles prédéfinies peuvent être sélectionnés. Un réseau de microphones peut obtenir des informations de rencontre audio, par l'intermédiaire du réseau de microphones, à l'aide d'au moins l'un parmi le ou les faisceaux sélectionnés et la ou les valeurs nulles sélectionnées.
Patent EP-4240761-A1 (EP)
Inventor: ALLALI SLIMANE
IPC: C07K16/24
Filed: 2021-11-04
Abstract: Acute chest syndrome (ACS) is a common and potentially lethal form of acute lung injury in sickle cell disease (SCD). Because pathophysiology remains unclear, therapeutic options are limited to supportive care with empiric antibiotics and red cell transfusion in case of aggravation. A role of inflammation mediated by endothelial and immune cells has been suspected but the levels of pro-inflammatory cytokines and chemokines in the lungs during ACS have not yet been investigated. Here the inventors report dramatically high levels of IL-6, unlike IL-1β and TNF-α, in the sputum from SCD children during ACS (n=12) compared with non-ACS sputum (n=6). By contrast, plasma IL-6 levels were not significantly increased during ACS (n=12), compared with vaso-occlusive crisis (n=12), steady state (n=12) and healthy controls (n=9). IL-6 levels were more than 150-fold higher in sputum than in plasma, suggesting increased local production by inflammatory cells during ACS. Sputum levels of IL-8, CCL2 and CCL3 chemokines were also increased during ACS, which may contribute to the recruitment of innate immune cells, such as neutrophils and monocytes, in the lungs. The results strongly suggest an involvement of these inflammatory mediators in ACS pathophysiology and open new therapeutic perspectives, in particular with IL-6 inhibitors.
Patent EP-4151236-A1 (EP)
Inventor: PARK JUN HONG
IPC: A61K47/69
Filed: 2021-05-13
Abstract: The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.
Patent EP-4251896-A1 (EP)
Title: Dispositif et procédé d'installation d'un joint d'étanchéité sur une bague de roulement d'un roulement
Inventor: FRATILA BOGDAN
IPC: F16C43/04
Filed: 2021-11-03
Abstract: L'invention concerne un dispositif d'installation d'un joint d'étanchéité (11) sur une bague de roulement (5, 6) d'un roulement (4) qui comporte une bague intérieure (5) et une bague extérieure (6), comprenant une table d'installation (3) qui est conçue pour fixer l'une des bagues de roulement (5, 6) tout en faisant tourner simultanément l'autre bague de roulement (6, 5). Le dispositif d'installation comprend en outre un dispositif d'alimentation (2) qui est conçu pour presser un joint en forme de brin (11) dans une rainure (9, 10) située dans la bague de roulement rotative (5, 6) en un processus continu.
Patent EP-4158491-A1 (EP)
Inventor: MAU SANDRA
IPC: G06F16/00
Filed: 2021-05-28
Abstract: A method for searching an image database, comprising receiving an adulterated image of an object, the adulterated image including object annotations for visual reference, applying a first neural network to the adulterated image, correlating a result of the applying the first neural network with each image of a reference database of images, the result including an edited image of the object and each image of the reference database of images including a reference object, and selecting, as a matching image, at least one image of the reference database of images having correlation values above a threshold correlation value. The method may include applying a masking to the adulterated image. The masking may include performing, via a second neural network, object recognition on the adulterated image, applying, based on the object recognition, computer vision to detect callout features relative to bounding boxes, and generating a contour mask of the object.
Patent EP-4116709-A1 (EP)
Title: Insulin detection method and detection kit
Inventor: FUNABASHI HISAKAGE
IPC: G01N27/02
Filed: 2021-05-14
Abstract: The invention provides a method capable of detecting a trace amount of insulin contained in a sample. 
The invention relates to an insulin detection method including: adding a sample to an electrode having an insulin binding protein immobilized on a surface of the electrode, the insulin binding protein specifically recognizing a site of insulin; and detecting an electrochemical change associated with formation of a complex of the insulin and the insulin binding protein. The insulin binding protein includes a first region that includes an α-CT segment of an insulin receptor and does not include a β subunit of the insulin receptor and a second region that includes an L1 domain of the insulin receptor and does not include the β subunit of the insulin receptor, and one of the first region and the second region is immobilized on the surface of the electrode.
Patent EP-4237453-A1 (EP)
Title: Vectorized tnf-alpha antagonists for ocular indications
Inventor: WANG XU
IPC: C07K19/00
Filed: 2021-10-29
Abstract: Provided are methods and compositions for the delivery of fully human post-translationally modified therapeutic TNF receptor Fc fusions. The fully human post-translationally modified therapeutic TNF receptor Fc fusions may be delivered by gene therapy methods, e.g., as a recombinant adeno-associated virus (rAAV) vector to the appropriate tissue. Also provided are methods of treating ocular indications such as non-infectious uveitis with the fully human post-translationally modified therapeutic TNF receptor Fc fusions.
Patent EP-4166001-A1 (EP)
Inventor: LEE SUNG EUN
IPC: A23B9/10
Filed: 2021-06-02
Abstract: The present disclosure relates to a method for producing fermented green coffee beans and fermented green coffee beans produced thereby, the method including: (A) a step of freezing green coffee beans at -10 to -25 °C; (B) a step of immersing the frozen green coffee beans in water for 3 to 10 hours; (C) a step of taking out the green coffee beans immersed in the water, removing the water and leaving the beans to stand for 5 to 15 hours while supplying air at 20 to 30 °C; (D) a step of sterilizing the green coffee beans and then inoculating the same with a strain to anaerobically ferment the same; and (E) a step of sterilizing and then drying the anaerobically fermented green coffee beans. When the fermented green coffee beans are roasted into coffee beans, aroma and taste may be improved and odor may be removed.
Patent EP-4161603-A1 (EP)
Inventor: SZERESZEWSKI KAMA
IPC: A61L27/52
Filed: 2021-06-08
Abstract: Provided herein are dermal fillers including decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed; as well as methods and uses thereof for cosmetic and/or reconstructive applications. Also provided are methods for preparing such dermal fillers, and dermal filler kits.
Patent EP-4152122-A1 (EP)
Inventor: PARK GYEONGTAE
IPC: G06F3/0354
Filed: 2021-06-10
Abstract: Disclosed is an electronic device. The electronic device includes a base housing, a sliding housing that at least partially overlaps the base housing and that is coupled to the base housing so as to slide, a folding housing that at least partially overlaps the base housing and that is connected to the sliding housing, a display disposed on the folding housing and the sliding housing, at least a portion of the display being located inside the base housing, a rolling module that is coupled to a rear surface of the display and that has one side connected to the sliding housing and an opposite side extending into an inner space of the base housing, and a hinge module connected to the folding housing and the sliding housing such that the sliding housing rotates about a first rotational axis and the folding housing rotates about a second rotational axis. The electronic device is configured to be capable of a sliding operation in which the folding housing and the sliding housing move in a sliding direction to extend or retract a display region of the electronic device and a folding operation in which the folding housing is folded or unfolded relative to the sliding housing to fold or unfold a portion of the display region. Besides, it may be permissible to prepare various other embodiments speculated through the specification.
Patent EP-4071615-A1 (EP)
Inventor: Zheng Yicong
IPC: G06N10/00
Filed: 2021-09-09
Abstract: This application discloses a quantum error correction (QEC) decoding system and method, a fault-tolerant quantum error correction (FTQEC) system, and a chip, and relates to the field of quantum technologies. The QEC decoding system includes a plurality of error correction chips. The error correction chips are configured to: obtain error syndrome information of a quantum circuit; and decode the error syndrome information by running neural network decoders, to obtain error result information, a core operation of the neural network decoders being a multiply accumulate (MA) operation of unsigned fixed-point numbers obtained through numerical quantization. According to his application, for the system that uses the neural network decoders for QEC decoding, the core operation of the neural network decoders is the MA operation of unsigned fixed-point numbers obtained through numerical quantization, thereby minimizing the data volume and the calculation amount desirable by the neural network decoders, so as to better meet the requirement of real-time error correction.
Patent EP-4256346-A1 (EP)
Inventor: JULKUNEN HELI
IPC: G01N33/68
Filed: 2021-12-02
Abstract: L'invention concerne une méthode permettant de déterminer si un patient présente un risque de développer une anémie et/ou un état métabolique liés à l'état nutritionnel et/ou à l'équilibre fluidique du sang.
Patent EP-4259227-A1 (EP)
Inventor: BENTVELSEN PETRUS HENRICUS CORNELIUS
IPC: A61M1/06
Filed: 2021-12-10
Abstract: :A breast pump comprises an expression system. Audible and/or tactile feedback is generated for a user of the breast pump by controlling the expression system.