Patent AU-2013203619-B2 (AU)
Title: Antibodies to matrix metalloproteinase 9
Inventor: ADAMKEWICZ JOANNE I
IPC: A61P35/00
Filed: 2013-02-28
Granted: 2015-02-26
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/130905 Al 6 September 2013 (06.09.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 39/395 (2006.01) A61K38/16 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K38/17(2006.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, ) .a BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, PCT/US2013/028456 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 28 February 2013 (28.02.2013) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: PCT/US2012/027160 (84) Designated States (unless otherwise indicated, for every 29 February 2012 (29.02.2012) US kind of regional protection available): ARIPO (BW, GH, 61/605,181 29 February 2012 (29.02.2012) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 61/755,444 22 January 2013 (22.01.2013) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: GILEAD BIOLOGICS, INC. [US/US]; 333 EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Lakeside Drive, Foster City, CA 94404 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventors: ADAMKEWICZ, Joanne I.; 333 Lakeside TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Drive, Foster City, CA 94404 (US). SMITH, Victoria; ML, MR, NE, SN, TD, TG). 333 Lakeside Drive, Foster City, CA 94404 (US). THAI, Published: Zung; 333 Lakeside Drive, Foster City, CA 94404 (US). - with international search report (Art. 21(3)) HAWKINS, Michael, J.; 333 Lakeside Drive, Foster City, CA 94404 (US). - before the expiration of the time limit for amending the claims and to be republished in the event of receipt of - (74) Agents: MULLEN, James J. et al.; Morrison & Foerster amendments (Rule 48.2 (h)) LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US). (54) Title: ANTIBODIES TO MATRIX METALLOPROTEINASE 9 Peptidase M10 (Zn Dependent Metalloproteinase) Signal Peptidoglycan Propeptide Collagen AHEXGHXXGXXH Hemopexin Peptide Binding Leavage Site Binding (Zn Binding Site) Domains Domain PRCGXPD Domains -111------- PGBD ---- --IF -f-R 92 x-- Tetrapeptde Repeats nfl(No resentin Other MMPs) (57) Abstract: The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and an O tigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).