Patent SG-11201908932S-A (SG)
Title: Process for making arylomyin ring analogs
Inventor: PETRONIJEVIC FILIP
IPC: A61P31/04
Filed: 2018-03-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit °nolo monium mu Imo oimIE (10) International Publication Number WO 2018/183198 Al (51) International Patent Classification: C07D 245/02 (2006.01) A61P 31/04 (2006.01) A61K 31/395 (2006.01) (21) International Application Number: PCT/US2018/024351 (22) International Filing Date: 26 March 2018 (26.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/477,268 27 March 2017 (27.03.2017) US (71) Applicant (for US only): GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080 (US). (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 BASEL (CH). (72) Inventors: PETRONIJEVIC, Filip; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). LIM, Ngiap-Kie; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). WONG, Nicholas; c/o Genentech, Inc., 1 DNA Way, South San Francisco, Cal- ifornia 94080 (US). HONG, Allen; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). HOU, Haiyun; 1321 Orleans Street, Apt. 1814, Detroit, Michigan 48207 (US). LINGHU, Xin; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). GOSSELIN, Francis; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). (74) Agent: HALL, Robert C. et al.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) (54) Title: PROCESS FOR MAKING ARYLOMYIN RING ANALOGS O c (57) : Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R 1 , R 2 , R7, R8, R 9 , R 5 , R10 and t• —gi are as defined herein. R 3 , R, R 4 5 , R6,