Patent SG-11201806750W-A (SG)
Title: Substituted 1,2,3-triazoles as nr2b-selective nmda modulators
Inventor: CHEN GANG
IPC: C07D409/14
Filed: 2017-02-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/139428 Al 17 August 2017 (17.08.2017) WIPO I PCT 111111111111110111011111111111010111110 011101111110111110111110111111111110111111 (51) International Patent Classification: CO7D 401/12 (2006.01) A61P 25/24 (2006.01) CO7D 401/14 (2006.01) A61P 25/28 (2006.01) CO7D 403/12 (2006.01) A61P 25/06 (2006.01) CO7D 403/14 (2006.01) A61P 25/02 (2006.01) CO7D 405/14 (2006.01) A61P 25/04 (2006.01) CO7D 409/14 (2006.01) A61P 25/30 (2006.01) A61K 31/4192 (2006.01) A61P 9/10 (2006.01) A61P 25/16 (2006.01) (21) International Application Number: PCT/US2017/017093 (22) International Filing Date: 9 February 2017 (09.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/293,680 10 February 2016 (10.02.2016) US (71) Applicant: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30, 2340 BEERSE (BE). (72) Inventors: CHEN, Gang; 3210 Merryfield Row, San Diego, California 92121 (US). CHROVIAN, Christa C.; 3210 Merryfield Row, San Diego, California 92121 (US). COATE, Heather R.; 3210 Merryfield Row, San Diego, California 92121 (US). DVORAK, Curt A.; 3210 Merry- field Row, San Diego, California 92121 (US). GELIN, Christine F.; 3210 Merryfield Row, San Diego, California 92121 (US). HISCOX, Afton; 3210 Merryfield Row, San Diego, California 92121 (US). LETAVIC, Michael A.; 3210 Merryfield Row, San Diego, California 92121 (US). RECH, Jason C.; 3210 Merryfield Row, San Diego, Cali- fornia 92121 (US). SOYODE-JOHNSON, Akinola; 3210 Merryfield Row, San Diego, California 92121 (US). STENNE, Brice; 3210 Merryfield Row, San Diego, Cali- fornia 92121 (US). WALL, Jessica L.; 3210 Merryfield Row, San Diego, California 92121 (US). ZHANG, Wei; 3210 Merryfield Row, San Diego, California 92121 (US). (74) Agents: ATKINS, Michael J. et al.; JOHNSON & JOHN- SON, One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 17 / 139 428 Al (54) Title: SUBSTITUTED 1,2,3-TRIAZOLES AS NR2B-SELECTIVE NMDA MODULATORS (57) : Substituted 1,2,3-triazoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by NR2B re- ceptor activity.