Patent SG-11201808237U-A (SG)
Title: Substituted indole compound derivatives as dengue viral replication inhibitors
Inventor: BARDIOT DOROTHÉE ALICE MARIE-EVE
IPC: C07D491/048
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111 HO 11111 0111011110011111H101011111110111011 1111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/167952 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (74) Agent: VERBERCKMOES, Mr. Filip; J&J Patent Law A61K 31/404 (2006.01) C07F 9/00 (2006.01) Department Turnhoutseweg 30, 2340 Beerse (BE). A61P 31/12 (2006.01) C07D 491/048 (2006.01) C07D 209/14 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/EP2017/057662 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 31 March 2017 (31.03.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 16163482.9 1 April 2016 (01.04.2016) EP ZA, ZM, ZW. (71) Applicants: JANSSEN PHARMACEUTICALS, INC. (84) Designated States (unless otherwise indicated, for every [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ kind of regional protection available): ARIPO (BW, GH, New Jersey 08560 (US). KATHOLIEKE UNI- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, VERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 3000 Leuven (BE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: BARDIOT, Dorothee Alice Marie-Eve; c/o LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — Cistim Leuven vzw Gaston Geenslaan 2, 3001 Leuven SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, _ (Heverlee) (BE). BONFANTI, Jean-Francois; c/o GW, KM, ML, MR, NE, SN, TD, TG). Janssen-Cilag 1 rue Camille Desmoulins, TSA 91003, = 92787 Issy-les-Moulineaux Cedex 9 (FR). COESEMANS, Declarations under Rule 4.17: Erwin; Janssen Pharmaceutica NV Turnhoutseweg 30, — be c/o as to applicant's entitlement to apply for and granted a 2340 Beerse (BE). KESTELEYN, Bart Rudolf Romanie; patent (Rule 4.1700) = c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 — Beerse (BE). MARCHAND, Arnaud Didier M; c/o Cis- Published: Leuven Gaston Geenslaan 2, 3001 Leuven — international 21(3)) tim vzw (Hever- with search report (Art. lee) (BE). RABOISSON, Pierre Jean-Marie Bernard; with sequence listing part of description (Rule 5.2(a)) = c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 = Beerse (BE). = = = = = = = = 1-1 ei kr) 0\ IN 1-1 (54) Title: SUBSTITUTED INDOLE COMPOUND DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS 1-1 © (57) : The present invention concerns substituted indole compounds, methods to prevent or treat dengue viral infections by N using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or 0 prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara- tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.