baber/WOPTO huggingface dataset:
Patent IL-92828-A0 (IL)
Title: Diol metabolites of 7-phenyl-1,2,4-triazolo(2,3-c)pyrimidines-5-amines and pharmaceutical compositions containing them
IPC: A61P9/12
Filed: 1989-12-21
Abstract: A glycol of a triazolopyrimidine diuretic of formula (I) which is a metabolite and which exhibits fewer cardiotoxic side effects than the parent compound, but with no decrease in diuretic activity. The invention further provides for compositions incorporating the metabolite, and methods of its use as well as pharmaceutically acceptable salts thereof. <CHEM>
Patent AU-PP628298-A0 (AU)
Title: Improved footwear garment
IPC: D04B1/26
Filed: 1998-10-01
Abstract: A sock type garment adapted for wearing on a wearer foot including a sole (3), partial upper foot (5), a heel (8, 9) and a toe (11, 12) wherein said heel and toe are shaped to assist accommodation of the respective parts of the wearers foot characterised in that an opening (4) for insertion of the wearers foot is provided intermediate of said heel and toe in the region of the partial upper foot.
Patent IL-102468-A0 (IL)
Title: Retractable antenna
IPC: H01Q1/24
Filed: 1992-07-10
Abstract: An antenna assembly comprises an elongate antenna element (11) mounted in a support (5) and movable between a retracted position (see Figure 2) and an extended position (see Figure 1). A helical antenna element (12) is carried at one end of the elongate element. The support (5) comprises a pair of concentric conductors (9,10) which provide a coaxial feed to the antenna elements (11, 12). Suitably the support (5) comprises a dielectric tube (6) having respective conductive portions (9,10) provided on the inner and outer faces thereof. The elongate antenna element is slidably mounted within the central conductor (9). In the retracted position both ends of the elongate antenna element are electrically connected to the central conductor (9). The elongate antenna element is thus rendered inactive as a radiating element and essentially becomes part of the central coaxial feed coupled directly to the helical antenna element. The invention provides a compact and convenient dual antenna arrangement ideally suited for use in a portable cellular radio telephone. <IMAGE>
Patent IL-106519-A0 (IL)
Title: 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/58
Filed: 1993-07-29
Abstract: A compound of formula (I):    <IMAGE>  (I)  wherein R is a hydrogen atom or a C1-C4 alkyl group; A is a single bond or a straight or branched C1-C6 alkylene chain; R1 is a hydrogen atom or a C1-C6 alkyl group; R2 is a C1-C6 alkyl group, a C5-C7 cycloalkyl or a C6-C10 cycloalkylalkyl group, aryl or a C7-C10 arylalkyl group, or a C6-C10 heterocyclylalkyl group; R3 is hydrogen, a C1-C4 alkyl group or an aryl or a C7-C10 arylalkyl group; Z is a C1-C6 alkyl group, an -OR5 group wherein R5 is a C1-C6 alkyl group,   <IMAGE>   group wherein each of R6 and R7 is hydrogen, C1-C6 alkyl, C5-C7 cycloalkyl, phenyl or R6 and R7 taken together with the nitrogen to which they are linked form a pentatomic or hexatomic saturated heteromonocyclic ring; and the symbol   represents a single or a double bond, is a testosterone 68 5 alpha -reductase inhibitor and is therapeutically useful in benign prostatic hyperplasia, prostatic and breast cancers, seborrhoea, female hirsutism and male pattern baldness.
Patent IL-106872-A0 (IL)
Title: Manufacture of cinnamic acid derivatives
IPC: B01J23/44
Filed: 1993-09-02
Abstract: PCT No. PCT/EP93/02317 Sec. 371 Date Apr. 28, 1994 Sec. 102(e) Date Apr. 28, 1994 PCT Filed Aug. 27, 1993 PCT Pub. No. WO94/05621 PCT Pub. Date Mar. 17, 1994.A novel process for the manufacture of a cinnamic acid derivative of the formula    <IMAGE>  I  wherein R1 signifies hydrogen or C1-8-alkyl and R2 signifies hydrogen, C1-10-alkyl, C1-10-hydroxyalkyl or C1-4-alkoxy-C1-10-alkyl, is described in which a 4-R1O-halobenzene is reacted with acrylic add or an acrylic acid ester CH2=CHCOOR2 using a heterogeneous palladium catalyst in the presence of the alkanoic acid ammonium salt formed from a C2-5-alkanoic acid and an aliphatic mono-, di- or trialkylamine or heterocyclic amine. In the case of the manufacture of the cinnamic acid derivative I in which R2 signifies hydrogen, the reaction can be carried out in the presence of the amine in place of the alkanoic acid ammonium salt. A further aspect of the described invention comprises reacting the 4-R1O-iodobenzene with the product of the Michael addition of an acrylic acid ester CH2=CHCOOR2', wherein R2' has the above significance of R2 except hydrogen, with an aliphatic or heterocyclic primary of secondary amine using a heterogeneous palladium catalyst and in the presence of a C2-5-alkanoic add in order to manufacture the above cinnamic add derivatives with the exception of the substituted cinnamic acid itself. In view of their UV-B absorbing properties the thus-manufactured cinnamic acid derivatives are suitable as UV-B filters for cosmetic agents, e.g. sunscreen agents.
Patent IL-110787-A0 (IL)
Title: Biodegradable polymer, its preparation and pharmaceutical composition containing it
IPC: C08L101/16
Filed: 1994-08-25
Abstract: This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF á, e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
Patent IL-111849-A0 (IL)
Title: Dithiocarbonimide derivative, fungicidal/insecticidal/acaricidal composition containing said derivative as active ingredient, intermediate for use in production of said derivative and process for producing said derivative from said intermediate
IPC: C07D307/52
Filed: 1994-12-02
Abstract: There is disclosed a dithiocarbonimide derivative of the formula:   <CHEM> wherein B is a C1-C6 alkyl group; X is an NH group or an oxygen atom and Y is a nitrogen atom or a CH group, A is a phenyl group, a heterocyclic group, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a bicycloalkyl group or a tricycloalkyl group, all of which may be substituted. Also disclosed are a fungicidal/insecticidal/acaricidal agent containing the dithiocarbonimide derivative as an active ingredient, an intermediate for use in the production of the dithiocarbonimide derivative, and a process for producing the dithiocarbonimide derivative from the intermediate.
Patent IL-122960-A0 (IL)
Title: Pharmaceutical compositions for use in the treatment of colonic adenomas
IPC: A61K31/5415
Filed: 1996-07-15
Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.
Patent IL-125726-A0 (IL)
Title: Service provision system for use in distributed processng environments
IPC: G06F9/44
Filed: 1997-02-12
Abstract: An agent (50) in a distributed computing environment includes a negotiation management module (NMM) (51) which is invoked when it is necessary to form a contract with another external agent for providing a particular service, a resource management module (RMM) (52) which manages resources controlled by the agent, a service/task management module (SMM) (53) which launches and controls services and tasks associated with the agent, and a communications module (CM) (56) which is the focus for both incoming and outgoing messages to and from the agent. The agent (50) is also provided with an acquaintance model (AM) (55) which provides an overall picture of services offered by other agents in the environment and a self model (SM) (54) which maintains a representation of the services which the agent (50) can itself provide. When requested to provide a service, the NMM (51) negotiates with the requestor, via the CM (56), on the basis of information provided by the RMM (52) relating to resources available to the agent (50). When a contract is finalised, the RMM (52) oversees the management of the resources controlled by the agent and the SMM (53) controls the services and tasks required by the agent (50) to complete the contract.
Patent IL-128546-A0 (IL)
Title: Cycloalkyl inhibitors of protein farnesyltransferase
IPC: C07K5/06
Filed: 1997-12-16
Abstract: Novel inhibitors of protein farnesyltransferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer, restenosis, atherosclerosis, psoriasis and endometriosis.
Patent IL-133733-A0 (IL)
Title: Bioprocess for preparing 7-aca
IPC: C12R1/82
Filed: 1999-12-27
Abstract: Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:   1) an expandase gene, e.g., from Cephalosporium acremonium, whose expression product converts the adipoyl-6-APA by ring expansion to adipoyl-7-ADCA; 2) an hydroxylase gene whose expression product converts the 3-methyl side chain of adipoyl-7-ADCA to 3-hydroxymethyl, to give the first product, adipoyl-7-aminodeacetylcephalosporanic acid (7-ADAC); and 3) an acetyltransferase gene whose expression product converts the 3-hydroxymethyl side chain to the 3-acetyloxymethyl side chain of adipoyl-7-ACA. The final product, 7-ACA, is then prepared by cleavage of the adipoyl side chain using an adipoyl acylase. The entire synthesis, accordingly, is carried out using bioprocesses, and is efficient and economical.
Patent IL-139304-A0 (IL)
Title: Optical window assembly for use in a supersonic platform
IPC: B64C1/14
Filed: 2000-10-26
Abstract: An optical window assembly including an outer window, an inner window and a housing. The outer window and the inner window are mounted in the housing, holding the outer window and the inner window apart, forming an intervening space between the outer window and the inner window. <IMAGE>
Patent IL-140044-A0 (IL)
Title: Compounds with growth hormone releasing properties
IPC: A61K38/05
Filed: 1999-06-29
Abstract: The invention relates to novel compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
Patent IL-149433-A0 (IL)
Title: Sms automatic reply and automatic handling
IPC: H04M3/53
Filed: 2002-05-01
Abstract: A system and method for enabling improved management of SMS messages, and in particular automatic replies, forwarding, filtering, saving and deleting of SMS messages on a wireless handset or alternative SMS enabled device. An SMS Center is used for managing SMS messages, an Auto-Reply Message Server (ARMS) stores Auto-Reply Messages and allows a message receiver to set up, change, or delete Auto-Reply Messages, and an SMS Automatic Handling Server (SAHS) handles message instructions for a message receiver. The ARMS and SAHS may be separate components, a unified component, and may be operational such that only one of them may be included in the system. <IMAGE>
Patent IL-150624-A0 (IL)
Title: Method of reducing the vapour pressure of ethanol-containing motor fuels for spark ignition combustion engines
IPC: C10L1/02
Filed: 2001-01-24
Abstract: Method of reducing the vapour pressure of a C3 to C12 hydrocarbon-based motor fuel mixture containing 0.1 to 20 % by volume of ethanol for conventional spark ignition internal combustion engines, wherein, in addition to an ethanol component (b) and a C3 to C12 hydrocarbon component (a), an oxygen-containing additive (c) selected from at least one of the following types of compounds: alcohol other than ethanol, ketone, ether, ester, hydroxy ketone, ketone ester, and a heterocyclic containing oxygen, is used in the fuel mixture in an amount of at least 0.05 by volume of the total fuel, is disclosed. A mixture of fuel grade ethanol (b) and oxygen-containing additive (c) usable in the method of the invention is also disclosed. <IMAGE>
Patent IL-163453-A0 (IL)
Title: Enzyme inhibitor in leukemia
Filed: 2004-08-10
Abstract: The invention relates to the use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia, preferably acute leukemia and more preferably for the treatment of AML
Patent IL-165829-A0 (IL)
Title: N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
IPC: A61K31/444
Filed: 2003-06-27
Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are bridged analogues of N-heteroaryl diazaspirocyclic compounds, or prodrugs or metabolites of these compounds. The aryl group can be a five or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic cholinergic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain. The compounds can (i) alter the number of nicotinic cholinergic receptors in the brain of the patient, (ii) exhibit neuroprotective effects and (iii) when employed in effective amounts, not result in appreciable side effects (e.g. side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastrointestinal tract, and significant effects upon skeletal muscle).
Patent IL-185234-A0 (IL)
Title: Aircraft engine fuel supply
Filed: 2007-08-13
Abstract: A centrifugal pump driven by mechanical coupling with an engine has a low pressure inlet receiving fuel from a fuel circuit of an aircraft, a high pressure outlet connected to a regulator circuit for regulating the flow rate of fuel supplied to the engine, and an assistance pump unit that is electrically controlled, having an inlet connected to the aircraft fuel circuit and an outlet connected to the flow rate regulator circuit so as to deliver, via its outlet, fuel that is at a predetermined minimum pressure, the pressure of the fuel supplied to the regulator circuit being the higher of the pressures delivered by the centrifugal pump and the assistance pump unit.
Patent IL-210671-A0 (IL)
Title: Machine- readable form configuration and system and method for interpreting at least one user mark
Filed: 2011-01-16
Abstract: Method and system for detecting user marks, comprising placing a form in a field of view of a camera, wherein the form includes thereon at least a first fiducial mark and a second fiducial mark; wherein the fiducial marks both comprise an outline portion and an interior portion; detecting the first and second fiducial marks; utilizing the camera to generate an electronic image of at least a portion of the form; calculating a distance between at least the first fiducial mark and the second fiducial mark; detecting at least a first user marking cell on the form based at least in part upon the calculated distance between the first fiducial mark and the second fiducial mark; calculating a displacement vector of the detected first user marking cell versus an ideal planar position of the detected first user marking cell; detecting at least a second user marking cell on the form, wherein the second user marking cell is detected based at least in part upon the displacement vector of the detected first user marking cell; determining evidence of at the first and second user marks based at least in part upon a degree of brightness similarity between: (a) at least a portion of the electronic image surrounding the indicium bounding the respective user marking cell; and (b) at least a portion of the electronic image included inside the indicium bounding the respectiveuser marking cell.
Patent IL-211084-A0 (IL)
Title: Single use module
Filed: 2011-02-06
Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
Patent RO-135988-A0 (RO)
Title: Process for preparing multi-element alloys from the alloy class alcrfeni
Inventor: SCUTELNICU ELENA
IPC: C22C30/00
Filed: 2022-04-21
Abstract: The invention relates to a process for preparing multi-element alloys of the AlCrFeNi class, also microalloyed with other chemical elements such as C, Nb, Mn, Mo, Ta or W, by electric arc melting of a bundle of rods/wires and the deposition of the resulting multi-element material on various metal substrates, the structures of multi-element alloys characterized by special properties of resistance to wear, oxidation, corrosion and impact being meant to be used in the chemical, petrochemical, military, naval, machine building, transport and mining industries. According to the invention, the process consists in depositing a melt of a bundle (4) of rods on a substrate (5) using TIG welding in a protective Ar atmosphere (2), the rods (4) having various chemical compositions, depending on the desired recipe of multi-element alloy (3), with identical or different diameters, the parameters of the melting regime being established in such a way as to ensure the complete and uniform melting of the rod materials by positioning the rods with the higher melting temperature in the upper zone of the bundle, under the direct action of the electric arc, finally obtaining a homogeneous layer of multi-element alloy (3) consisting of a plurality of adjacent partially overlapping layers, where the increase of the degree of chemical homogenization and the improvement of the properties of the alloy deposited by welding can be obtained by remelting the deposits in different directions: transverse, longitudinal or combined transverse and longitudinal, in relation to the initial direction of deposition, using the TIG process without filler material.
Patent LU-68214-A1 (LU)
IPC: C08F220/04
Filed: 1973-08-13
Abstract: 1437176 Copolymers containing anhydride units IMPERIAL CHEMICAL INDUSTRIES Ltd 18 July 1973 [14 Aug 1972 13 June 1973] 37804/72 and 28170/73 Heading C3P A thermoplastic copolymer comprising from 50 to 99% by weight of the copolymer of units derived from a main ethylenically unsaturated monomer which monomer is either an alkyl methacrylate having from 1 to 4 carbon atoms in the alkyl group or styrene optionally containing up to 15% by weight of the main monomer used of other of other copolymerizable ethylenically unsaturated monomers excluding ethylenically unsaturated carboxylic acids, and correspondingly from 1 to 50% by weight of the copolymer of a mixture of ethylenically unsaturated carboxylic acid and carboxylic acid anhydride units derived from an α-substituted acrylic acid, at least 5% by weight of the mixture being in the form of anhydride units and wherein the copolymer has a melt flow index of at least 0À1 may be prepared by treating the polymerization product of a main ethylenically unsaturated monomer and an α-substituted acrylic acid at a temperature above its full Vicat softening point until at least 5% by weight of the copolymerized α- substituted acrylic acid has been converted to carboxylic acid anhydride units. In the examples copolymers of methacrylic acid, methyl methacrylate, styrene and n-butyl acrylate are extruded into lace using an extruder fitted with a vacuum degassing vent system.
Patent MA-27481-A1 (MA)
Title: Derives de proline presentant une affinite pour la sous-unite alpha-2-delta du canal calcium
Inventor: RAWSON DAVID JAMES
IPC: C07D405/12
Filed: 2005-04-29
Abstract: DEPOSANT Société  dite : PFIZER  INC. REVENDICATION DE PRIORITES GB 31 Octobre 2002 0225379.7 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de proline présentant une affinité pour la sous-unité  alpha-2-delta du canal calcium Les composés de formule (I) ou un de leurs sels, produits de solvatation ou précurseurs médicamenteux pharmaceutiquement acceptables sont des dérivés de proline utiles dans le traitement de l'épilepsie, d'attaques de lipothymie, de 1'hypokinésie, de troubles cr??niens, de troubles neurodégénératifs, de la dépression, de l'anxiété, de la panique, de la douleur, de la fibromyalgie, de l'arthrite, de troubles neuro-pathologiques, de troubles du sommeil, de troubles douloureux viscéraux et de troubles gastro-intestinaux. Des procédés pour la préparation des produits finals et des intermédiaires utiles dans le procédé sont inclus. Des compositions pharmaceutiques contenant un ou plusieurs des composés sont également incluses. Formule dans laquelle soit X représente un atome de O ou S, un groupe NH ou CH2 et Y  représente un groupe CH2 ou une liaison directe, soit Y représente un atome de 0 ou S ou un groupe NH, et X représente un groupe CH2 ; et R représente un groupe cycloalkyle tri- à dodécagonal, hétérocycloalkyle tétra- à dodécagonal, hétéroaryle ou aryle, n'importe quel noyau pouvant être facultativement substitué avec un ou plusieurs substituants choisis indépendamment entre des substituants halogéno, hydroxy, cyano, nitro, amino, hydroxycarbonyle, alkyle en C1 à C6, alcényle en C1 à C6, alcynyle en C1 à C6, alkoxy en C1 à C6, hydroxyalkyle en C1 à C6, (alkoxy en C1 à C6) (alkyle en C1 à C6) , perfluoralkyle en C1 à C6, perfluoralkoxy en C1 à C6, alkylamino en C1 à C6, di(alkyle en C1 à C6) amino, aminoalkyle en C1 à C6, (alkyle en C1 à C6) amino (alkyle en C1 à C6) , di (alkyle en C1 à C6) amino (alkyle en C1 à C6) , acyle en C1 à C6, acyloxy en C1 à C6, (acyle en C1 à C6) oxy (alkyle en C1 à C6) , acylamino en C1 à C6, alkylthio en C1 à C6, (alkyle en C1 à C6) thiocarbonyle, alkylthioxo en C1 à C6, (alkoxy en C1 à C6)carbonyle, alkylsulfonyle en C1 à C6, alkylsulfonylamino en C1 à C6, aminosulfonyle, alkylaminosulfonyle en C1 à C6, di(alkyle en C1 à C6)aminosulfonyle, cycloalkyle tri- à octogonal, hétérocycloalkyle tétra- à octogonal, phényle et hétéroaryle monocyclique ; ou un sel, produit de solvatation ou précurseur médicamenteux pharmaceutiquement acceptable de ces composés.
Patent MA-27501-A1 (MA)
Title: Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3
Inventor: ARANYI PETER
IPC: A61P17/00
Filed: 2005-06-13
Abstract: L'invention concerne des composés de formule (I), dans laquelle X, Z, R1 -R10, m, n, o, p, r sont, comme dans la description, de préférence de forts antagonistes des ligands récepteurs de l'adénosine A3.
Patent MA-27802-A1 (MA)
Title: Composes d'acide benzoique 1,2,4-oxadiazole et utilisation de ceux-ci dans la suppression non-sens et le traitement de maladies.
Inventor: KARP GARY MITCHELL
IPC: C07D413/04
Filed: 2005-11-09
Abstract: L'invention concerne des composés d'acide benzoïque 1,2,4-oxadiazoIe, des procédés d'utilisation et des compositions pharmaceutiques renfermant un dérivé de l'acide benzoïque 1,2,4-oxadiazole. Parmi les procédés d'utilisation, on peut citer des méthodes de traitement ou de prévention d'une maladie améliorée par la modulation de la fin précoce de la translation ou de la dégradation des ARNm induite par non-sens ou d'amélioration d'un ou plusieurs symptômes associés à celle-ci.