baber/WOPTO huggingface dataset:
Patent CA-2269659-A1 (CA)
Title: Hydrolase binding assay
Inventor: SKOREY KATHRYN
IPC: C07K5/08
Filed: 1997-11-03
Abstract: Disclosed is a binding assay for proteases and phosphatases, which contain cysteine in their binding sites or as a necessary structural component for enzymatic binding. The sulfhydryl group of cysteine is the nucleophilic group in the enzyme's mechanistic proteolytic and hydrolytic properties. The assay can be used to determine the ability of new, unknown ligands and mixtures of compounds to competitively bind with the enzyme versus a known binding agent for the enzyme, e.g., a known enzyme inhibitor. By the use of a mutant form of the natural or native wild-type enzyme, in which serine, or another amino acid, e.g., alanine, replaces cysteine, the problem of interference from extraneous oxidizing and alkylating agents in the assay procedure is overcome.  The interference arises because of oxidation or alkylation of the sulfhydryl, -SH (or -S-), in the cysteine, which then adversely affects the binding ability of the enzyme. Specifically disclosed is an assay for tyrosine phosphatases and cysteine proteases, including capsases and cathepsins, e.g., Cathepsin K(O2), utilizing scintillation proximity assay (SPA) technology. The assay has important applications in the discovery of compouds for the treatment and study of, for example, diabetes, immunosuppression, cancer, Alzheimer's disease and osteoporosis. The novel feature of the use of a mutant enzyme can be extended to its use in a wide variety of conventional colorimetric, photometric, spectrophotometric, radioimmunoassay and ligand-binding competitive assays.
Patent CA-2273016-A1 (CA)
Inventor: LIN YNG-LANG
IPC: F04B27/04
Filed: 1997-11-24
Abstract: This invention relates to a gas compressor including several compression units that can respectively compress air and generate a lot of compressed gas with little power. These compression units are mounted on the rotary or rotated assemblies and are able to rotate therewith, and the air is compressed while the said units are turning down with the aid of gravity.
Patent CA-2275550-A1 (CA)
Title: Magnetometer and dielectrometer detection of subsurface objects
Inventor: ZAHN MARKUS
IPC: G01V3/08
Filed: 1998-01-06
Abstract: A detection apparatus discriminates between metallic mines and other buried objects by detecting the depth of the object, the size, the shape and the orientation of the object and the electrical properties of the object. A dielectric sensor having a first electrode and a second electrode is used in one embodiment. The first electrode is driven with a varying voltage to establish a varying electric field through the ground to the second electrode. The voltage magnitude and phase of the second electrode are measured. Another apparatus, a magnetometer sensor, detects objects containing metal located below the surface of the ground. This apparatus has a plurality of parallel, spaced linear conductor sets disposed in proximity to the ground. An electromagnetic field is imposed in the ground with a dominant spatial wavelength through the conductor elements. A resulting electromagnetic response of the object in the ground to the imposed magnetic field is sensed.      The conductor sets may have varying number of individual conductors.
Patent CA-2278643-A1 (CA)
Title: Solid electrolytic capacitor and method for producing the same
Inventor: KONUMA HIROSHI
IPC: H01G9/04
Filed: 1998-11-27
Abstract: A solid electrolytic capacitor provided with a solid electrolyte layer on the dielectric film formed on the surface of a valve-action microporous metal sheet, wherein at least part of the solid electrolyte layer takes a layer structure. Particularly, a solid electrolytic capacitor having (1) a solid electrolyte layer made of a conductive polymer having specific fused-ring structures in which sulfoquinone anions having both sulfo anion groups and quinone structures and other anions are contained and (2) a solid electrolyte layer made of a conductive polymer having specific fused-ring structures in which anthracenesulfonic acids and other anions are contained.
Patent CA-2280680-A1 (CA)
Inventor: HARTMANN REINHARD WILHELM
IPC: G09F11/12
Filed: 1999-08-25
Abstract: The invention relates to a display device with a housing and at least one endless traction means which is guided over several deflection devices and movable via a driving device, with several display units which are rotatingly arranged at the traction means, and at least one device for rotating the display units, wherein each display unit comprises a plurality of display bodies which are rotatingly supported at a display support which in turn is rotatingly supported at the traction means. Display units of such a construction enable a quick change of at least four different picture displays which results in an increase of the total display surface and thus to a faster amortisation of the costs of the purchase of the display device.
Patent CA-2282201-A1 (CA)
Inventor: STIMPL JOHANN
IPC: D03C3/20
Filed: 1999-09-15
Abstract: There is described an apparatus for forming sheds for a jacquard machine by means of hooks (7), which are movably guided in a frame between a high position and a low position, and a lifting means (9) for the hooks (7) which can each selectively be coupled with associated driver stops (11) of the lifting means (9) via a control element (14) that is mounted in the frame and is adjustable transverse to the path of movement of the hooks (7) by means of a control means. To create advantageous constructional conditions it is proposed that the driver stops (11) of the lifting means (9) can be swivelled from a stop-limited drive position into a rest position outside the path of movement of the counter-stops (13) of the hooks (7), and that the control elements (14) on the one hand have a cam track (21, 22) for swivelling the driver stops (11) of the lifting means (9) and on the other hand a holding stop (18) for the hooks (7) in the high position.
Patent CA-2282527-A1 (CA)
Title: Method for making soft magnetic parts from particulate ferrous material, and parts made therefrom
Inventor: LASHMORE DAVID S
IPC: B22F1/17
Filed: 1998-02-27
Abstract: A method is provided for making soft magnetic parts from particulates of ferrous material. The methods includes the following steps. Providing a plurality of ferrous particles and coating at least one substantially uniform layer of from about 0 wt.% to about 15 wt.% of a metal onto each of the particles. The coated particles are consolidated to form a part, and the part is heated at a temperature and for a time period sufficient to promote the formation of intermetallic phases between the metal layer and the ferrous particle at the boundary therebetween. The intermetallic phases have an electrical resistivity of greater than about 100 ohms/mil-ft.
Patent CA-2287266-A1 (CA)
Inventor: HENNEMANN PASCAL
IPC: B05B11/00
Filed: 1998-04-28
Abstract: Distributeur de produits conditionnés sous forme de liquide, crème ou gel, particulièrement destinés à des applications cosmétiques, dermatologiques, pharmaceutiques, ophtalmiques ou en parfumerie, du type comprenant un réservoir (1) de produit (2) raccordé par l'une de ses extrémités à une tête pourvue d'une pompe (4) équipée d'un moyen d'obturation contrôlée de l'évent (40) réalisé sur le corps (41) de ladite pompe (4) et d'une douille (3) de fixation caractérisé en ce que ledit moyen d'obturation comprend un élément de diffusion (6) perméable à l'air et contenant des agents non migrants pour le traitement bactériologique et/ou chimique de l'air par contact; ledit élément (6) étant emboîté sur le corps (41) de pompe, et retenu par serrage radial périphérique étanche d'au moins une zone annulaire, d'une part, et par engagement de sa partie haute dans la douille (3) de fixation, d'autre part.
Patent CA-2288741-A1 (CA)
Title: 4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
Inventor: STEALEY MICHAEL A
IPC: A61P43/00
Filed: 1998-05-22
Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (I), wherein R1 and R2 are as described in the specification; and Ar1 is aryl optionally substituted with one or more radicals independently selected from halo, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkyldioxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, aminocarbonyl, cyano, alkoxycarbonyl, formyl, aminosulfonyl, alkylamino, nitro, arylamino, alkylcarbonylamino, halosulfonyl, aminoalkyl, and haloalkyl; and HetAr2 is pyridinyl, pyrimidinyl or quinolinyl optionally substituted with one or more radicals independently selected from alkylthio, alkylsulfonyl, alkylsulfinyl, halo, alkyl, heterocyclyl, alkoxy, aralkoxy, haloalkyl, amino, cyano, aralkyl, alkylamino, cycloalkylamino, cycloalkenylamino, arylamino, alkynylamino, and aralkylamino; or a pharmaceutically-acceptable salt or a tautomer thereof.
Patent CA-2290911-A1 (CA)
Inventor: LAPRADE PAUL KEVIN
IPC: G01B5/255
Filed: 1999-11-29
Abstract: A method for adjusting the camber of a vehicle wheel having an axis of rotation and having camber adjustment means comprising the steps of loosening the wheel camber adjustment means while the wheel bears part of the motor vehicle's sprung mass, applying a clamp tool substantially vertically to the wheel whereby the tool straddles the wheel perpendicular to the axis of rotation, pivoting the tool and the wheel attached thereto perpendicular to the axis of rotation to a desired camber, and tightening said camber adjustment means. The clamp tool comprises a clamp having opposed inner and outer arms for engaging the respective inner and outer sidewalls of the wheel, at least one of the inner and outer clamp arms being extensible for engaging a wheel sidewall, means for adjusting the tool for snug engagement of the inner and outer arms with the wheel sidewalk, and lever means detachably connected to the tool for pivoting the tool and the wheel engaged by the tool.
Patent CA-2293096-A1 (CA)
Inventor: VANI CAROLE
IPC: A63F3/00
Filed: 1999-12-16
Abstract: Jeu de Société : Marque "Change de Job" comprend - 1 plateau - 2 dés - 6 pions - 4 paquets de cartes en couleurs : "Change de Job", "Situation de Famille", "Achat-Vente", "Chance." - 11 paquets de billets en couleurs, valeur en dollars : 1$, 5$, 100$, 200$, 500$, 1.000$, 5.000$, 10.000$.   - Jeu de société : marque : "Change de Job" comprend - 1 plateau couleur en carton, dimension (52cm x 47cm) comportant 33 cases numérotées. - 2 dés - 4 jeux de cartes en couleur : "Change de Job" -"Situation de Famille"-  "Achat/Vente" - "Chance".   - 45 cartes "Change de Job" (orange).   - 35 cartes "Situation de Famille"(jaune).   - 35 cartes "Achat/Vente" (grise).   - 35 cartes "Chance" (bleu).   - 5 cartes gagnantes sur lesquelles figurent les maisons  (n.degree. 1 à 4).    11 paquets de billets en couleurs, valeur en $,  dimention: 10cm x 5cm.   - 50 billets de   10 000$              - 80 billets de         50$  - 50 billets de   5 000$             - 80 billets de            20$   - 100 billets de  1 000$              - 80 billets de         10$   - 100 billets de  500$               - 80 billets de           5$   - 100 billets de   200$                - 80 billets de          1$   - 100 billets de    100$
Patent CA-2298033-A1 (CA)
Inventor: MUGRAGE BENJAMIN BIRO
IPC: C07C229/42
Filed: 1998-08-26
Abstract: Disclosed are the compounds of formula (I), wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro;  R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable prodrug esters thereof; as selective COX-2 cyclooxygenase inhibitors.
Patent CA-2299812-A1 (CA)
Title: Photo-thermal treatment device
Inventor: SUTTON DAVID B
IPC: A61N5/06
Filed: 2000-03-01
Abstract: An improved photo-thermal treatment device is disclosed which is ergonomically shaped to facilitate photo-thermal treatment of a wide variety of surface portions of the human anatomy. The device incorporates a plurality of spaced infrared diodes which are actuated sequentially so as to inhibit body adaptation which may reduce the effectiveness of the treatment. Additionally, a single point diode is provided at one end of the device which is specifically designed for localized point treatment of other body surface areas.
Patent CA-2300094-A1 (CA)
Title: Apparatus for cleaning a suspension, preferably a fiber mass suspension
Inventor: HAUTALA JOUKO
IPC: B03D1/14
Filed: 1998-09-17
Abstract: An apparatus for cleaning a fiber mass suspension, the apparatus comprising a receptacle (1) and an inlet channel (2) and an outlet channel (3) for feeding the suspension into and for discharging it from the receptacle. In addition, the apparatus comprises air feed means for feeding air into the lower portion of the receptacle (1). The apparatus comprises at least one partition wall (4) dividing the receptacle into spaces in such a way that the supension may flow between the spaces at the lower portion and the upper portion of the partition wall, respectively. The air feeding means are positioned to feed air into one aeration space (5a), whereby the air separates impurities from the suspension and makes the suspension flow on different sides of the partition wall (4) upwards and downwards, respectively, so that a spiral flow is created around the partition wall from the inlet channel (2) into the outlet channel (3).
Patent CA-2303252-A1 (CA)
Title: Internal combustion engines
Inventor: EHRLICH JOSEF
IPC: F01B9/02
Filed: 1998-09-03
Abstract: An internal combustion engine includes one or more pistons (4), each of which is mounted to reciprocate in a respective cylinder (2) and is pivotally connected to a connecting rod (6) which is connected to a respective crank (10) on a crankshaft (7). The connecting rod (6) is pivotally connected to one end (11) of an elongate link (14) which is pivotally connected to an associated crank (10) at a point intermediate its ends and whose other end constitutes a rod (18) which is restrained by a mounting (20, 26) such that it may pivot about a pivotal axis (21) parallel to the axis (8) of the crankshaft (7). The mounting includes a first movable mounting member (20) connected to a second movable mounting member (26) to be pivotable with respect thereto about the pivotal axis (21).      The first movable mounting (20) is connected to the rod (18) by a connection which permits only relative sliding movement in the direction of the rod (8). Actuating means (30, 32) is connected to the mounting and is arranged to move the mounting selectively in a first direction 32 perpendicular to the axis (8) of the crankshaft (7) and in a second direction perpendicular thereto.
Patent CA-2305596-A1 (CA)
Title: Guidewire compatible port and method for inserting same
Inventor: HAARALA BRETT
IPC: A61M25/09
Filed: 1998-10-01
Abstract: An access port assembly having an attachable catheter allows for inserting a guidewire into the catheter to aid in the placement of the integral catheter while still attached to the access port assembly. A  method is described for placing an access port fixedly attached to a catheter into a patient using a guidewire inserted into the catheter.
Patent CA-2306172-A1 (CA)
Title: Apparatus and method for automatically configuring settings of software application in a portable intelligent communications device
Inventor: BARATT MANON
IPC: H04Q7/32
Filed: 1998-10-22
Abstract: An apparatus and method for automatically configuring settings for a software application in a portable intelligent communications device, where the software application settings are dependent on certain geographical location information. The method includes the steps of determining a current geographical location for the portable intelligent communications device or setting a default location therefor, determining a geographical location for a party with whom the portable intelligent communications device is currently having an active voice conversation or with whom the portable intelligent communications device most recently had an active voice conversation, and integrating the geographical location information determined to automatically configure the settings of the software application.
Patent CA-2311882-A1 (CA)
Inventor: NAGAMINE MASAYUKI
IPC: H01M10/05
Filed: 2000-06-16
Abstract: A nonaqueous electrolyte battery having improved characteristics under a heavy load environment and incorporating nonaqueous electrolytic solution which contains vinylene carbonate in a proper quantity to improve conductivity of the nonaqueous electrolytic solution so that doping/dedoping of lithium ions is performed smoothly and, therefore, the internal resistance is decreased. Hence it follows that the initial capacity of the battery is enlarged and satisfactory heavy load characteristics are realized.
Patent CA-2312873-A1 (CA)
Title: Mold block with air flow control
Inventor: LUPKE MANFRED A A
IPC: B29C48/09
Filed: 1999-02-05
Abstract: A mold block which is used in a moving mold tunnel comprises first and second mold block sections (3, 5) which meet at their parting faces (4, 6) to close the mold block. Each mold block section has a product shaping interior surface (15, 35) and an air movement passage (11, 30). An air flow controller is provided in each mold block section (3, 5). Through various different positionings of the two air flow controllers, the mold block can be operated in any one of four different modes including a first vacuum forming mode in which air is withdrawn from the mold block through both of the mold block sections (3, 5), a second vacuum forming mode in which air is withdrawn from the mold block through only one of the mold block sections, a third cooling mode in which air is introduced into the mold block through one of the mold block sections and is then withdrawn from the other of the mold block sections and a fourth blow molding mode in which pressure within the mold block is released through both mold block sections (3, 5).
Patent CA-2313320-A1 (CA)
Title: Reversible electrochemical mirror
Inventor: WARREN LESLIE F JR
IPC: G02F1/1506
Filed: 1998-12-15
Abstract: An electrochemical mirror includes a transparent first electrode (106) and a second electrode (110) distributed in localized areas. An electrolytic solution (112) is disposed between the first and second electrodes and contains ions (116) of a metal which can electrodeposit on the first and second electrodes. A negative electrical potential (118) applied to the first electrode causes deposited metal to be dissolved from the second electrode into the electrolytic solution and to be electrodeposited from the solution onto the first electrode, thereby affecting the propagation of electromagnetic radiation through the mirror. A surface modification layer (108) applied to the first electrode ensures that the electrodeposit is substantially uniform, resulting in a mirror layer which increases the reflectivity of the mirror.  Conversely, a positive electrical potential (118) applied to the first electrode causes deposited metal to be dissolved from the first electrode and electrodeposited from the solution onto the second electrode, thereby increasing the transmissivity of the mirror.
Patent CA-2314985-A1 (CA)
Title: Computer method and apparatus for interacting with a physical system
Inventor: SCHMIDT CHRIS
IPC: A63F9/24
Filed: 1998-12-15
Abstract: A computer interface system and method is described which includes a way of interfacing with a physical game system (300, 105). The game system (300, 105) may include a platform having a plurality of regions and a plurality of lots, a plurality of environmental objects (302, 304, 306, 308, 310, 312, 314, 316, 318, 320) positioned within an associated lot of the platform, and a movable object (326) near at least one region. Additionally, each environmental object has an environmental identifier and is a global type or a local type, and each region has a region identifier and a plurality of subregions. The method includes the act of scanning the environmental objects and the movable object to extract data (503), where the extracted data includes a movable object position of the movable object and an environmental position for each environmental object and associated environmental identifier. The method also includes an act of determining which region is nearest to the movable object by analyzing the extracted data and computing the distance between the movable object and each region that is proximal to the movable object (504, 601). Additionally the method includes an act of determining which region identifier is associated with the nearest region to the movable object by analyzing the extracted data, determining whether any of the environmental objects are associated with the nearest region by analyzing the extracted data (504, 602), and determining whether any environmental identifiers are associated with the nearest region by analyzing the extracted data (504, 603). The method further includes the act of running an audiovisual program based at least on the determinations of the region identifier associated with the nearest region and any environmental objects that are associated with the nearest region (505).
Patent CA-2315237-A1 (CA)
Inventor: MANTELLE JUAN
IPC: A61K9/70
Filed: 1998-12-14
Abstract: The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein the methylphenidate is present in an amount sufficient to achieve substantially zero order kinetics for delivery to the skin or mucosa of a patient in need thereof over a period of time at least 10 hours.
Patent CA-2316548-A1 (CA)
Title: Surface stabilization of silicon rich silica glass using increased post deposition delay
Inventor: FORTIN VINCENT
IPC: H01L21/316
Filed: 2000-08-21
Abstract: A dielectric layer of silica glass by is formed plasma enhanced chemical vapour deposition (PECVD) wherein a gaseous precursor of the dielectric layer is supplied to a deposition chamber in the presence of an electromagnetic field. The supply of the gaseous precursor while continuing to maintain the electromagnetic field for a delay time exceeding 0.5 seconds after the discontinuation of the supply of the gaseous precursor. This improves the hydrophilic properties of said film. A siloxane-based SOG  film is deposited on the dielectric layer.
Patent CA-2316824-A1 (CA)
Inventor: PICHOT CHRISTIAN
IPC: G01N33/553
Filed: 1999-01-06
Abstract: The invention concerns magnetic and heat-sensitive particles having a predetermined size between 0.05 and 10 µm, each particle comprising: an inner composite core consisting of a solid organic or inorganic particle, containing within it a magnetic filler; an outer coating based on a polymer capable of interacting with at least a biological molecule, the outer polymer is heat-sensitive and has a predetermined low critical solubility temperature (LCST) ranging between 10 and 100 ·C and preferably between 20 and 60 ·C. The invention also concerns methods for obtaining said particles and their uses. The particles are characterised in that there is an intermediate layer between the inner core and the outer layer isolating said inner core magnetic filler with respect to said functionalised outer layer. Said invention is particularly useful for separating proteins and/or nucleic acids.