baber/WOPTO huggingface dataset:
Patent CA-3172600-A1 (CA)
Title: Rna particles comprising polysarcosine
Inventor: HAAS HEINRICH
IPC: C12N15/88
Filed: 2021-03-24
Abstract: The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The RNA particles in one embodiment comprise single-stranded RNA such as mRNA which encodes a peptide or protein of interest, such as a pharmaceutically active peptide or protein. The RNA is taken up by cells of a target tissue and the RNA is translated into the encoded peptide or protein, which may exhibit its physiological activity.
Patent CA-3173658-A1 (CA)
Title: Advantageous therapies for disorders mediated by ikaros or aiolos
Inventor: PROIA DAVID
IPC: A61K31/403
Filed: 2021-08-06
Abstract: New treatments for Ikaros and/or Aiolos mediated disorders are provided that comprise administering an effective amount of a cereblon binder that degrades Ikaros or Aiolos by the ubiquitin proteasome pathway.
Patent CA-3174364-A1 (CA)
Title: Caspase inhibition to enhance regeneration and repair after skin or gut injury and to treat bacterial and viral infections
Inventor: GARZA LUIS
IPC: A61P31/14
Filed: 2021-03-30
Abstract: The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.
Patent CA-3174577-A1 (CA)
Title: A vehicle with a protective warning system
Inventor: MANKOWSKI PETER
IPC: B60W50/14
Filed: 2021-02-26
Abstract: A protective warning system for a vehicle is provided. A device comprises: a long-range camera and a stereoscopic camera positioned in a housing to image external objects in a rear-facing direction when the housing is mounted to a vehicle. A controller detects, using images from the long-range camera, an external object in the rear-facing direction and process stereoscopic images from the stereoscopic camera to determine when the external object is located with a first zone or a second zone extending in the rear-facing direction, the second zone being closer to the stereoscopic camera than the first zone. In response to determining that the external object is located with the first zone or the second zone, the controller controls the one or more notification devices to provide one or more first or second notifications associated with a first or second urgency level.
Patent CA-3176007-A1 (CA)
Inventor: EDWARDS BRIAN
IPC: F28F25/08
Filed: 2020-12-04
Abstract: A fill sheet for cooling heat transfer fluid in a cooling tower includes an air intake end, an air outlet end, a top edge and a bottom edge. The air outlet end is positioned opposite the air intake end along a lateral axis. The top edge connects the air intake end and the air outlet end and the bottom edge also connects the air intake end and the air outlet end. The bottom edge is positioned opposite the top edge along a vertical axis. A plurality of flutes extends generally parallel to the lateral axis between the air intake end and the air outlet end. An offset extends generally parallel to the vertical axis. A first flute of the plurality of flutes transitions from a first peak at a first side of the offset to a first valley at a second side of the offset.
Patent CA-3176939-A1 (CA)
Inventor: BULLWINKEL WILLIAM H
IPC: A47B96/06
Filed: 2022-09-27
Abstract: Devices, systems and methods for hanging and securing items for display are provided.  Hanger devices of the present disclosure are self-locking, secure and do not require special tools to install and/or remove. A hanger for displaying at least one item of merchandise relative to a structure includes a first hanger member and a second hanger member that are removably coupled to each other, the first hanger member and second hanger member forming a retaining portion that retains the hanger to a structure and a hanging portion that enable items of merchandise to be placed thereon and be displayed. Additionally, a hanger capture device is provided to be mounted to a slatwall to prevent hangers from being removed from the slatwall.
Patent CA-3177654-A1 (CA)
Inventor: MOLNAR DENNIS
IPC: C07C219/20
Filed: 2021-05-04
Abstract: L'invention concerne des formes polymorphes de (R)-oxybutynine HC1, y compris trois formes cristallines, qui sont préparées et caractérisées. L'invention concerne également des utilisations des différentes formes polymorphes de (R)-oxybutynine HC1 pour le traitement de l'apnée obstructive du sommeil (OS A).
Patent CA-3178103-A1 (CA)
Title: Image processing apparatus, image processing method, program, and image processing system
Inventor: KONO KENICHI
IPC: A61B6/12
Filed: 2021-05-07
Abstract: The present disclosure pertains to a feature for supporting a healthcare worker during a catheter examination or medical treatment of a blood vessel so as to facilitate concentration on work in an area of attention and provide support in making a determination regarding the area of attention. More specifically, in an image processing device 1, an image acquisition unit 110 acquires an X-ray image, created on the basis of an absorption rate of X-rays, where at least a blood vessel and a device for examining or medically treating the inside of the blood vessel is included in a photographic subject. A region-of-interest acquisition unit 111 receives, as a region-of-interest, one or a plurality of regions including at least a portion of the device included in the X-ray image. A tracing unit 112 traces each region-of-interest in the X-ray image. If at least any one region-of-interest satisfies a condition established for each region-of-interest, a notification unit 113 notifies a user of the image processing device 1 regarding such. The present disclosure also includes recording actions during a surgery and displaying a list of tools that are used.
Patent CA-3178559-A1 (CA)
Title: Orthogonally linked multimeric oligonucleotides
Inventor: BROWN JONATHAN MILES
IPC: C12N15/87
Filed: 2021-05-18
Abstract: Orthogonally linked multi-conjugates (such as multimeric oligonucleotides) are disclosed, along with methods of synthesizing them using orthogonal linking strategies to join together subunits that are biological moieties.
Patent CA-3180089-A1 (CA)
Title: Noyau pour ski et ski incluant un tel noyau
Inventor: MIETTE PHILIPPE
IPC: A63C5/00
Filed: 2022-10-26
Abstract: Ski (1) comprenant un noyau (4) comportant ¨ un chant latéral gauche (42G), ¨ un chant latéral droit (42D) et, ¨ au moins une âme centrale (44, 44G, 442D) placée entre les deux chants latéraux. Le noyau comprend également ¨ une pluralité d'ailettes gauches (46G) disposée entre au moins une âme centrale (44, 44G) et le chant latéral gauche (42G), chaque ailette gauche faisant un angle compris entre 5 et 85 ou entre 95 et 175 avec l'axe longitudinal X, ¨ une pluralité d'ailettes droite (46D) est disposée entre au moins une âme centrale (44, 44D) et le chant latéral droit (42D), chaque ailette droite faisant un angle compris entre 5 et 85 ou entre 95 et 175 avec l'axe longitudinal X.
Patent CA-3180682-A1 (CA)
Title: Porous material for removing impurities in feedstocks
Inventor: WEISE CHRISTIAN FREDERIK
IPC: B01J20/08
Filed: 2021-07-06
Abstract: The invention relates to a porous material comprising alumina, said alumina comprising alpha-alumina, said porous material comprising one or more metals selected from Co, Mo, Ni, W and combinations thereof, and said porous material having a BET-surface area of 1-110 m2/g, a total pore volume of 0.50-0.80 ml/g, as measured by mercury intrusion porosimetry, and a pore size distribution (PSD) with at least 30 vol% of the total pore volume being in pores with a radius ? 400 Å, suitably pores with a radius ? 500 Å, such as pores with a radius up to 5000 Å. The invention relates also to a process for removing impurities such as phosphorous (P) from a feedstock such as a renewable feed, by contacting said feedstock with a guard bed comprising the above porous material. The invention further relates to a guard bed for a hydrotreatment system comprising the porous material, a hydrotreatment system comprising a guard bed which comprises the porous material and a downstream hydrotreatment section comprising at least one hydrotreatment catalyst, as well as to the use of the porous material as a phosphorus guard in a hydrotreatment process.
Patent CA-3181054-A1 (CA)
Title: Carbon dioxide reduction catalyst and carbon dioxide reduction method
Inventor: MURAYAMA TORU
IPC: B01J23/89
Filed: 2021-04-19
Abstract: The present invention provides a carbon dioxide reduction catalyst that is used in reduction reactions of carbon dioxide and that has high methanol selectivity. A carbon dioxide reduction catalyst according to the present invention is used in producing methanol by reduction reactions of carbon dioxide, and contains Au and Cu as catalyst components and ZnO as a carrier. It is preferable that the catalyst components contain 7-25 mol% of Au as a catalyst component. This makes it possible to obtain high methanol selectivity for example, selectivity of not less than 80%. The carbon dioxide reduction catalyst makes it possible to obtain high methanol selectivity even under the conditions of not more than 240°C and not more than 50 bar.
Patent CA-3183172-A1 (CA)
Title: Selection de patient a base de biomarqueur de traitement par inhibiteur de proteasome
Inventor: WINTER JACOB M
IPC: C12Q1/6886
Filed: 2021-06-17
Abstract: L'invention divulgue une méthode ou une composition quelconque parmi les méthodes ou les compositions de l'invention. L'invention divulgue des méthodes de traitement d'un sujet atteint d'un cancer consistant à administrer un inhibiteur de protéasome au sujet atteint d'un cancer, le sujet ayant un cancer ayant un gène AT ADI non fonctionnel. L'invention divulgue des méthodes de diagnostic et de traitement du cancer, la méthode consistant à : diagnostiquer un sujet comme étant sensible à un traitement par un inhibiteur de protéasome ; et administrer un inhibiteur de protéasome au sujet.
Patent CA-3184163-A1 (CA)
Inventor: KVALE SVEIN
IPC: A61P31/04
Filed: 2021-05-27
Abstract: The present invention relates to ultrasound mediated delivery of antimicrobial agents to sites of infection, and particularly for treatment of infections. Thus, the invention provides a cluster composition and a pharmaceutical composition, for use in delivery and preparation for administration of antimicrobial agents and treatment of infections.
Patent CA-3185874-A1 (CA)
Title: System and method for automated document generation
Inventor: BRECQUE CHARLES
IPC: G06F16/34
Filed: 2021-06-08
Abstract: A semantic document generation system is described. The semantic document generation system receives an indication of a type of a document to be generated and plurality of terms for the document from a plurality of sources. The terms are converted into triples. A plurality of rules governing the terms of the document is applied to the triples to generate a knowledge graph and determine whether terms from the different parties are compatible. The terms are determined to be compatible in a case where the plurality of rules governing terms of the document is satisfied. If at least one set of terms is non-compatible, the system reconciles the non-compatible terms in the generated knowledge graph until all the terms are compatible, and generates the document based at least on the reconciled knowledge graph.
Patent CA-3186985-A1 (CA)
Title: Electrode pour l'evolution electrochimique d'hydrogene
Inventor: CALDERARA ALICE
IPC: C25B1/46
Filed: 2021-06-22
Abstract: La présente invention concerne une électrode et, en particulier, une électrode appropriée pour être utilisée en tant que cathode pour le développement d'hydrogène dans des procédés électrolytiques industriels, pourvue d'un revêtement catalytique comprenant une couche externe contenant du ruthénium et du sélénium ; et un procédé de production de celle-ci.
Patent CA-3187564-A1 (CA)
Inventor: HUNG Ju-Sung
IPC: C12Q1/6844
Filed: 2021-06-21
Abstract: La présente divulgation concerne des procédé et des systèmes d'identification d'acide nucléique. L'identification d'une molécule d'acide nucléique peut comprendre la génération, dans une pluralité de chambres, d'une pluralité de molécules d'acide nucléique double brin, la dénaturation des molécules d'acide nucléique double brin et la détection de signaux de la dénaturation pour générer un ou plusieurs profils de dénaturation. Le ou les profils de dénaturation peuvent être utilisables pour identifier des molécules d'acide nucléique. Les procédés et le système décrits ici peuvent permettre l'identification de multiples molécules d'acide nucléique à partir d'une seule analyse.
Patent CA-3188204-A1 (CA)
Inventor: GRINBERG ASYA
IPC: C07K16/28
Filed: 2021-08-05
Abstract: Sont divulguées des protéines comprenant des domaines variables de chaîne lourde et de chaîne légère d'anticorps qui peuvent être appariés pour former un site de liaison à l'antigène ciblant EGFR sur une cellule, des compositions pharmaceutiques comprenant de telles protéines, et des méthodes thérapeutiques faisant appel à de telles protéines et compositions pharmaceutiques, notamment pour le traitement du cancer.
Patent CA-3188956-A1 (CA)
Title: Novel aav capsids and compositions containing same
Inventor: WILSON JAMES M
IPC: A61K48/00
Filed: 2021-08-13
Abstract: Provided herein are novel AAV capsids and recombinant AAV vectors comprising the same. In one embodiment, vectors employing a novel AAV capsid show increased transduction of a selected target tissue as compared to a prior art AAV.
Patent CA-3189717-A1 (CA)
Inventor: LAMBLE RALPH
IPC: B01L3/00
Filed: 2021-08-26
Abstract: A device containing a retaining mechanism comprising: a resiliently biased latch member adapted for motion between at least three positions; a fusible retaining member having at least one engagement surface configured to engage with and act as a stop to the motion of the latch member between two of said positions; and a heating member positioned adjacent to the retaining member; wherein one motion of the latch member between said positions causes it to engage with the fusible retaining member and stop said motion, and activation of the heating member affects at least a portion of the fusible retaining member causing it to soften, melt, weaken or break allowing the latch member to move so as to release the latch member for a further motion between said positions
Patent CA-3192503-A1 (CA)
Inventor: ADAMO ROBERTO
IPC: A61K39/095
Filed: 2021-08-23
Abstract: The inventors have identified a combined vaccine for immunisation against bacterial meningitis caused by multiple pathogens.
Patent CA-3193452-A1 (CA)
Inventor: RAJASEKHARAN RAJAKRISHNAN P
IPC: G06Q50/08
Filed: 2021-09-01
Abstract: A method and system for monitoring operations of a machine (100) operating at a worksite, is provided. The machine (100) includes an implement (118) for performing one or more implement operations and is powered by an engine (109). The method includes determining a first parameter corresponding to an engine speed associated with the engine (109), a second parameter indicative of vibrations detected inside the operator cabin and a third parameter indicative of a machine speed associated with the machine (100). The method further includes determining a machine operation as one of the loading operation (404), the dumping operation (408) and a travelling operation (412) based on one or more of the determined first parameter, second parameter and the third parameter.
Patent CA-3199421-A1 (CA)
Inventor: BRADLEY WILLIAM D
IPC: A61K45/06
Filed: 2021-11-18
Abstract: L'invention concerne des méthodes de traitement d'un cancer de la prostate ayant au moins une mutation du RA pathogène à l'aide de 7-chloro-2-(4-(3-méthoxyazétidin-1-yl)cyclohexyl)-2,4-diméthyl-N-((6-méthyl-4-(méthylthio)-2-oxo-1,2-dihydropyridin-3-yl)méthyl)benzo[d][1,3]dioxole-5- carboxamide, ou d'un sel pharmaceutiquement acceptable de ce composé, seul ou en combinaison avec une quantité thérapeutiquement efficace d'un inhibiteur de la signalisation du récepteur des androgènes (ARSI), tel que l'enzalutamide.
Patent CA-3201551-A1 (CA)
Inventor: FREEMAN JOHN J
IPC: A61K9/00
Filed: 2021-12-07
Abstract: A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprise diketopiperazine particles for pulmonary inhalation.
Patent CA-3201672-A1 (CA)
Title: Procede de synthese d'electrolyte solide, composition d'electrolyte a l'etat solide et cellule electrochimique
Inventor: CARLSON BENJAMIN
IPC: H01M10/0562
Filed: 2021-12-10
Abstract: Procédé de synthèse d'un électrolyte à l'état solide dans lequel P2S5, Na2S et LiCl sont dissous dans un ou plusieurs solvants; lors de la réaction du mélange, le NaCl est précipité hors de la solution et éliminé de cette dernière; le solvant est éliminé; et l'électrolyte à l'état solide de sulfure est séché, puis cristallisé pour être utilisé dans une batterie à l'état solide. L'invention concerne également une batterie à l'état solide comprenant l'électrolyte solide à base de sulfure produit.
Patent CA-3201794-A1 (CA)
Inventor: XIE YONGHUI
IPC: F25B41/00
Filed: 2021-12-08
Abstract: L'invention concerne un dispositif et un procédé de stockage d'énergie reposant sur un changement de phase gaz-liquide de dioxyde de carbone. Le dispositif de stockage d'énergie reposant sur un changement de phase gaz-liquide de dioxyde de carbone comprend : un stockage de gaz (100) ; un réservoir de stockage de liquide (200) ; un ensemble de stockage d'énergie (300), l'ensemble de stockage d'énergie (300) étant agencé entre le réservoir de gaz (100) et le réservoir de stockage de liquide (200), et le dioxyde de carbone étant changé d'un état gazeux à un état liquide à travers l'ensemble de stockage d'énergie (300) ; un ensemble de libération d'énergie (400), l'ensemble de libération d'énergie (400) étant agencé entre le stockage de gaz (100) et le réservoir de stockage de liquide (200), et le dioxyde de carbone étant changé de l'état liquide à l'état gazeux par l'intermédiaire de l'ensemble de libération d'énergie (400) ; un ensemble d'échange de chaleur (500), l'ensemble de stockage d'énergie (300) et l'ensemble de libération d'énergie (400) étant tous deux reliés à l'ensemble d'échange de chaleur (500), et l'ensemble d'échange de chaleur (500) étant apte à transférer une partie de l'énergie générée dans l'ensemble de stockage d'énergie (300) à l'ensemble de libération d'énergie (400) ; et un ensemble de récupération de chaleur, au moins l'une de l'énergie libérée lorsque le dioxyde de carbone est changé de l'état gazeux à l'état liquide, l'énergie libérée lorsque le dioxyde de carbone est refroidi avant d'entrer dans le stockage de gaz (100) et l'énergie libérée lorsqu'un milieu d'échange de chaleur est refroidi est récupérée par l'ensemble de récupération de chaleur et utilisée pour l'évaporation du dioxyde de carbone. Le dispositif peut réduire les déchets d'énergie dans des processus de stockage et de libération et améliorer le taux d'utilisation d'énergie.
Patent CA-3201976-A1 (CA)
Title: Electric-powered locomotive apparatus and method
Inventor: MULLIGAN KYLE R
IPC: B61C3/00
Filed: 2022-08-19
Abstract: A locomotive has DC or AC traction motors, powered by a hydrogen fuel cell, and optionally other sources such as regenerative braking. The traction motors of the locomotive may be connected to a set of independent DC choppers or AC inverters, linked via a common DC bus, configured to regulate power from the one or more power sources. A manager module, among other functions, may receive inputs and signals to coordinate delivery of electricity from the sources to the motor.  A method for retrofitting a legacy locomotive may include removing a generator and a control apparatus configured for diesel fuel, and installing a kit of apparatus configured to be powered by a hydrogen fuel cell. A railway system for use by locomotives powered by hydrogen has one or more hydrogen-generation stations deployed near a track of the railway system.
Patent CA-3202773-A1 (CA)
Inventor: NALLS MIKE
IPC: C07D471/12
Filed: 2021-10-25
Abstract: L'invention concerne des méthodes de traitement de patients atteints de la maladie de Parkinson (MP) associée à LRRK2 de type sauvage. L'invention reconnaît que l'analyse de modificateurs génétiques de LRRK2 chez de tels patients permet l'identification des patients qui répondront à des inhibiteurs de LRRK2. Ainsi, l'invention concerne des procédés d'identification de patients MP qui répondront à des inhibiteurs de LRRK2, ainsi que des méthodes de traitement de tels patients.
Patent CA-3205189-A1 (CA)
Inventor: MAGNELL GREGORY P
IPC: B31B50/14
Filed: 2022-01-13
Abstract: A system comprises a corrugator single facer configured to receive a first web and a second web, to corrugate the first web and adhere the first web in a corrugated state to the second web in an uncorrugated state to form a single face corrugated web as output. The system also includes a folder gluer operatively connected to receive the single face corrugated web from the corrugated single facer. The folder gluer is configured to fold and adhere the single-face corrugated web into a tube.
Patent CA-3206533-A1 (CA)
Inventor: RIVERA JOSE S
IPC: A61F2/36
Filed: 2022-01-20
Abstract: L'invention concerne un outil et un procédé associé pour retirer un implant prothétique. Bien qu'il puisse être utilisé pour retirer une grande variété d'implants prothétiques différents, cet outil est mis en application en particulier pour le retrait d'implants fémoraux. Dans un mode de réalisation, on utilise à la fois un outil latéral et un outil médial. L'outil latéral présente une forme généralement arquée avec des parois latérales verticales qui définissent un intérieur arqué. L'outil latéral est ainsi dimensionné pour suivre le contour du côté latéral d'un implant fémoral. L'outil médial comprend des parois latérales opposées qui définissent une ouverture intérieure. L'ouverture est dimensionnée pour recevoir le col de l'implant fémoral, ce qui permet à l'outil de suivre étroitement l'interface os/implant médiale.
Patent CA-3206918-A1 (CA)
Inventor: RIZZI ENRICO
IPC: B01J8/02
Filed: 2022-02-09
Abstract: L'invention concerne un réacteur de synthèse catalytique, ledit réacteur comprenant un lit catalytique ayant une forme cylindrique annulaire délimitée par un collecteur d'entrée de gaz et un collecteur de sortie de gaz, au moins l'un desdits collecteurs ayant une structure à parois multiples comprenant une plaque perforée externe (1) ayant une fonction de support de charge, une plaque métallique expansée (2) servant d'élément d'espacement, et une mince plaque micro-perforée (3) faisant face au catalyseur et ayant une fonction de retenue du catalyseur.
Patent CA-3207299-A1 (CA)
Inventor: HAJJAR ROGER J
IPC: A61P21/00
Filed: 2021-01-08
Abstract: Some embodiments of the methods and compositions provided herein relate to treating, inhibiting or ameliorating a skeletal muscular dystrophy with a polynucleotide encoding a SERCA2a polypeptide. In some embodiments, the muscular dystrophy comprises Duchenne muscular dystrophy (DMD) or Becker's muscular dystrophy (BMD). In some embodiments, the polynucleotide comprises a viral vector, such as an adeno-associated viral (AAV) vector. More embodiments include methods and compositions to screen for a therapeutic agent to treat, inhibit or ameliorate a skeletal muscular dystrophy in which the screen comprises an in vitro ventricular cardiac tissue model.