baber/WOPTO huggingface dataset:
Patent AU-2019203813-A1 (AU)
Title: Simultaneous, Integrated Selection and Evolution of Antibody/Protein Performance and Expression in Production Hosts
Inventor: SHORT JAY MILTON
IPC: C12P21/06
Filed: 2019-05-31
Abstract: SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!TM) allows for simultaneous evolution of protein performance and expression optimization.
Patent AU-2019204959-A1 (AU)
Title: Residual current circuit breaker and method of testing same
Inventor: BEDETTI GINO MARK-ANTHONY
IPC: H02H3/16
Filed: 2019-07-10
Abstract: Abstract A residual current circuit breaker comprising a socket, the socket comprising at least first and second apertures configured to receive, removably, respective neutral and live pins of a plug connectable to an external residual current circuit breaker testing device. The residual current circuit breaker also comprises first and second conductors configured to connect, electrically, the neutral and live pins of the plug to respective neutral and live conductors of the residual current circuit breaker when the plug is in the socket. 14- - 12 Figure 1(a) 34i Figure 1 (b)
Patent AU-2019233446-A1 (AU)
Title: Thrombectomy device
Inventor: Bhogal Pervinder
IPC: A61B17/221
Filed: 2019-03-06
Abstract: The invention relates to a device (1) for removing thrombi from blood vessels, said device (1) having an expanded form, in which it is temporarily released in the blood vessel and a compressed form, in which it is inserted into and removed from the blood vessel through a microcatheter, wherein: the device (1) has a proximal portion (2), a central portion (3) and a distal portion (4), the central portion (3) being substantially cylindrical, the proximal portion (2) being coupled to an insertion aid (5), and the distal portion (4) having a substantially cylindrical main structure; and a narrowed section (6) is situated between the central portion (3) and the distal portion (4) and at least some of said distal portion (4) is provided with a covering in the form of a membrane (7). The device (1) according to the invention is characterised in that thrombus fragments that break free from the thrombus to be captured are captured securely and removed from the blood vessel.
Patent AU-2019262858-A1 (AU)
Title: System and method to maintain health using personal digital phenotypes
Inventor: NARAYAN SANJIV M
IPC: G06Q50/00
Filed: 2019-04-24
Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.
Patent AU-2019268193-A1 (AU)
Title: Conversion method, apparatus, computer device, and storage medium
Inventor: LIU SHAOLI
IPC: G06N3/06
Filed: 2019-03-29
Abstract: 769-1949831AU A model conversion method, apparatus, computer device, and storage device are disclosed. The method an convert an initial offline model to a target offline model. The model conversion method, apparatus, computer device, and storage device may greatly reduce data input of the computer device and have a simple conversion process, and may thus reduce an amount of data processing of the computer equipment, improve rocessing efficiency and reduce power consumption.
Patent AU-2019271922-A1 (AU)
Title: Biomarkers and methods of treating PD-1 and PD-L1 related conditions
Inventor: CHEN DANIEL SHIN-YU
IPC: G01N33/574
Filed: 2019-11-26
Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-i/PD-Li pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto. 11908978_1 (GHMatters) P100997.AU.2
Patent AU-2019298413-A1 (AU)
Title: Digital aroma dispersion system for predicting and mitigating motion sickness
Inventor: KELSEN KEITH
IPC: A61L9/03
Filed: 2019-08-07
Abstract: The present invention is directed to a digital aroma system that provides a scented air on demand in a vehicle to prevent or mitigate nausea. Fragrance cartridges are held in a fragrance module having a manifold and valves that are controlled by a processor. The system can open valves to direct an airflow through an anti-nausea fragrance cartridge in response to a user input, detected location of prior nausea, or detected nausea inducing vehicle motions.
Patent AU-2019302641-A1 (AU)
Title: Expandable medical device for use with a needle
Inventor: HARRIS COLBY
IPC: A61B17/34
Filed: 2019-07-10
Abstract: Medical devices, assemblies and methods for guarding sharp tips of medical needles are disclosed herein. Some embodiments include an expandable device configured to be at least partially disposed within the needle lumen. The device may include an expandable distal portion that is designed to shift between a first configuration in which the expandable distal portion has an outer diameter that is the same as or less than the inner diameter of the needle lumen and a second configuration in which the expandable distal portion has an outer diameter that is greater than the inner diameter of the needle lumen. An elongated inner member may be used to shift the expandable distal portion from the first configuration to the second configuration.
Patent AU-2019338674-A1 (AU)
Title: Bispecific antibody targeting IL-1R1 and NLRP3
Inventor: MCGILLIGAN VICTORIA
IPC: C07K16/18
Filed: 2019-09-16
Abstract: The present disclosure concerns modulators of the NLRP3 inflammasome pathway,in particular an NLRP3 inflammasome modulator which is capable of binding to both of IL-1R1 and NLRP3, for use in the treatment or prophylaxis of inflammatory eye diseases such as glaucoma.
Patent AU-2019339488-A1 (AU)
Title: Uses of plasminogen activator inhibitor 1 (PAI-1) inhibitors
Inventor: EDELSON JONATHAN
IPC: A61K31/4166
Filed: 2019-09-12
Abstract: The present disclosures provides surprising insight into new technologies for treatment and/or prevention of certain types of hair loss (also known as alopecia), including androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and senescent alopecia. Among other things, the present disclosure provides surprising insight that plasminogen activator inhibitor -1 (PAI-1) inhibitors may be surprisingly effective and/or useful in the treatment and/or prevention of certain types of hair loss, including androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and senescent alopecia. Furthermore, the present disclosure provides insight that provided new technologies may not be particularly effective and/or useful in the treatment and/or prevention of other types of alopecia such as radiation-induced alopecia, chemotherapy-induced alopecia, and alopecia due to chronic discoid lupus erythematosus.
Patent AU-2019370153-A1 (AU)
Title: Drag reduction and energy generation apparatus and method
Inventor: SHAH NASEEM Z
IPC: B62D37/02
Filed: 2019-10-08
Abstract: An apparatus and system provide drag reduction and energy efficiency for a transport vehicle. Cover sections (20) of transport vehicles (18) are formed to include solar arrays (300) and dielectric barrier discharge plasma actuator arrays (700). The vehicle cover (20) also generates electricity to charge onboard battery racks (410). The cover sections (20) are integral with and shaped to conform with areas such as a trunk lid (49) or roof (45). Fiber Bragg grating sensors (530) are placed to detect formation of a separation layer (2). Plasma actuator arrays (700) are actuated either to inhibit formation of the separation layer (2) or to create span-wise waves to reduce skin drag.
Patent AU-2019380703-A1 (AU)
Title: Monoclonal antibodies against AMBRA-1
Inventor: LOVAT PENNY
IPC: C07K14/47
Filed: 2019-11-04
Abstract: The present invention relates inter alia to the development of monoclonal antibodies against Ambra-1 and methods for determining whether a subject with melanoma has an increased risk of metastasis using said antibodies.
Patent AU-2019381776-A1 (AU)
Title: Therapeutic adeno-associated virus for treating Pompe disease
Inventor: O'CALLAGHAN MICHAEL W
IPC: C12N15/86
Filed: 2019-11-15
Abstract: Recombinant AAV (rAAV) vectors comprising a rAVV genome comprising a heterologous nucleic acid encoding a signal peptide and optionally a IGF-2 sequence, fused to an acid alpha-glucosidase (GAA) polypeptide, enabling the GAA polypeptide to be secreted from the liver and targeted to the lysosomes. Particular embodiments relate to a recombinant AAV (rAAV) vector encoding an alpha-glucosidase (GAA) polypeptide, having a liver secretory signal peptide and a targeting IGF2 sequence that binds human cation-independent mannose-6-phosphate receptor (CI-MPR) or to the IGF2 receptor, permitting proper subcellular localization of the GAA polypeptide to lysosomes. Also encompassed are cells, and methods to treat a glycogen storage disease type II (GSD II) disease and/or Pompe Disease with the rAAV vector.
Patent AU-2019423356-A1 (AU)
Title: Methanol production process from syngas produced by catalytic partial oxidation integrated with cracking
Inventor: CHINTA SIVADINARAYANA
IPC: C01B3/50
Filed: 2019-12-31
Abstract: A process for producing syngas and olefins comprising feeding a catalytic partial oxidation (CPO) reactant mixture (oxygen, first hydrocarbons, steam) to a CPO reactor (CPO catalyst); wherein the CPO reactant mixture reacts, via CPO reaction, in CPO reactor to produce a CPO reactor effluent (H
Patent AU-2019426692-A1 (AU)
Title: Unicondylar femoral prosthesis, tibia pad, and unicondylar replacement prosthesis
Inventor: SUN YANDONG
IPC: A61F2/38
Filed: 2019-12-23
Abstract: A unicondylar femoral prosthesis (100, 200, 200), a tibia pad (400), and a unicondylar replacement prosthesis. The unicondylar femoral prosthesis (100, 200, 300) comprises an osteotomy surface (120) for connecting to the femur and a joint surface (110) for abutting the tibia, the joint surface (110) comprising a distal end joint surface (111) and a posterior condyle joint surface (112). The distal end joint surface (111) has a first radius of curvature (Rd) on the sagittal plane (101) and the posterior condyle joint surface (112) has a second radius of curvature (Rp) on the sagittal plane, the range of the ratio of the first radius of curvature (Rd) to the second radius of curvature (Rp) being 1.4-2.1. The joint surface (110) has a third radius of curvature (Rc) on the coronal plane (102), the third radius of curvature (Rc) being equal to the first radius of curvature (Rd). The present unicondylar femoral prosthesis (100) better matches the anatomical structure of the human femoral joint surface, avoiding the problems of the insufficient coverage of the femoral distal end surface and excessive osteotomy, and improving the bearing performance of the joint surface (110) and the joint stability.
Patent AU-2019464406-A1 (AU)
Title: A method and system for the secure transmission of funds
Inventor: COOPER JOSEPH GORDON
IPC: G06Q40/04
Filed: 2019-09-02
Abstract: Method and system for transacting a secure money transfer which is operative to transfer funds, in a first currency, from a first sending bank account, at a first location, to a second recipient bank account at a second location. An aim of the invention is to provide a system that operates across borders and in real-time. Another aim of the invention is to provide a system that guarantees the existence of funds and ensures funds are transferred, thereby reducing the risk of banks of being exposed to Herstatt risk.
Patent WO-2020191446-A1 (WO)
Inventor: DICKSON MICHAEL
IPC: C02F1/24
Filed: 2020-03-26
Abstract: Disclosed herein is a method for remediating sewage that contains persistent contaminants. The method comprises ozofractionating the sewage under conditions whereby a foam fractionate comprising persistent contaminants is produced and separated from an ozofractionated wastewater, quiescing the ozofractionated wastewater, whereby a residual ozone content of the ozofractionated wastewater is reduced, and contacting the quiesced ozofractionated wastewater with a microorganism population under conditions effective to biologically remediate the ozofractionated wastewater.
Patent WO-2021016668-A1 (WO)
Inventor: CLARK GEORGINA JANE
IPC: A61K39/395
Filed: 2020-07-30
Abstract: La présente invention concerne un immunoconjugué comprenant un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie spécifiquement à CD300f, lié à au moins un agent cytotoxique, et des compositions comprenant l'immunoconjugué, et l'utilisation de l'immunoconjugué pour appauvrir des cellules souches et progénitrices hématopoïétiques, pour préparer un sujet pour une greffe de cellules souches hématopoïétiques, et pour le traitement d'états associés à CD300f.
Patent WO-2021087572-A1 (WO)
Inventor: MACEDO DAVID
IPC: G01N27/30
Filed: 2020-11-06
Abstract: L'invention concerne une électrode de référence à l'état solide qui comprend : un élément de référence en communication ionique avec un composite, le composite comprenant une matrice polymère perméable à l'eau chargée d'un sel inorganique solide comprenant un anion de référence ; une surface d'électrode permettant d'assurer une mise en contact avec un analyte ; et un matériau d'échange d'ions solide situé entre la surface d'électrode et l'élément de référence, le matériau d'échange d'ions solides comprenant un ou plusieurs ions non interférents ; lors de l'utilisation, le matériau d'échange d'ions solide immobilisant un ou plusieurs ions interférents, lorsqu'ils sont présents en solution dans l'analyte, par échange avec les ions non interférents.
Patent AU-2020200990-A1 (AU)
Title: Identification of MHC class I phospho-peptide antigens from breast cancer utilizing SHLA technology and complementary enrichment strategies
Inventor: HUNT DONALD F
IPC: C07K16/00
Filed: 2020-02-12
Abstract: IDENTIFICATION OF MHC CLASS 1 PHOSPHO-PEPTIDE ANTIGENS FROM BREAST CANCER UTILIZING SHLA TECHNOLOGY AND COMPLEMENTARY ENRICHMENT STRATEGIES Abstract The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.
Patent AU-2020214893-A1 (AU)
Title: Data compression method and base station
Inventor: HUANG QUFANG
IPC: H04L29/06
Filed: 2020-01-17
Abstract: Disclosed in the embodiments of the present application are a data compression method and a base station. The method comprises: a base station acquiring identification information of a data compression device and/or data decompression device; generating a dictionary according to the identification information; and sending the dictionary to the data compression device and the data decompression device, so that the data compression device and the data decompression device carry out data compression and data transmission according to the received dictionary. By using the embodiments of the present application, data packet compression can be implemented in an industrial private network on the basis of a UDC algorithm, and system operating efficiency can be improved.
Patent AU-2020223190-A1 (AU)
Title: Methods and apparatus for a magnetic propulsion system
Inventor: DANIEL THOMAS A
IPC: H02K53/00
Filed: 2020-02-14
Abstract: A propulsion system, comprising: a fan blade housing; a plurality of fan blades within the fan blade housing; one or more rows of permanent magnets, affixed to the outside of the fan blade housing; one or more fan blade bearings; one or more magnetic field generators affixed to the one or more fan blade bearings and corresponding to the one or more rows of permanent magnets, the magnetic field generators configured to cause the permanent magnets to be propelled forward in the same direction, thereby causing the fan blade housing to which they are attached, and the fan blades within, to spin.
Patent AU-2020239932-A1 (AU)
Title: Brake system for an articulated vehicle
Inventor: WALENTA CLAYTON D
IPC: B60T8/1764
Filed: 2020-02-06
Abstract: A brake system for an articulated vehicle is disclosed. The brake system includes a brake assembly (102) coupled to a traction device (14), the brake assembly being configured to apply a brake-assembly pressure (104) based on one of a hydro-mechanical pressure signal (106) and an electro-mechanical pressure signal (108). A blocking valve (118) is configured to block the hydro-mechanical pressure signal when closed. A brake controller (120), is configured to transmit an isolation signal (122) configured to close the blocking valve and transmit an ABS control signal (116) that is based on a commanded ABS brake pressure.
Patent AU-2020260940-A1 (AU)
Title: Composition comprising Actinidia polygama extract for alleviating skin damage or moisturizing skin
Inventor: PARK SU JIN
IPC: A61K36/185
Filed: 2020-04-24
Abstract: The present invention relates to a composition for alleviating ultraviolet ray-induced skin damage or for moisturizing the skin and, more particularly, to a composition comprising an Actinidia polygama extract as an active ingredient. The composition can alleviate the reduction of skin moisture caused by ultraviolet ray-induced skin barrier damage and the resultant skin dryness, reduced skin elasticity, and increased skin roughness and as such, can be applied to a food composition for alleviating ultraviolet ray-induced skin damage or for moisturizing the skin, and furthermore to a health functional food or pharmaceutical composition, an animal food composition, a pharmaceutical composition for animals, and a cosmetic composition.
Patent AU-2020273380-A1 (AU)
Title: Systems and methods for de-oxygenation of a closed container
Inventor: LUTZ THOMAS R
IPC: B65D39/00
Filed: 2020-11-20
Abstract: An oxygen scavenging device configured to scavenge oxygen from a headspace of a vessel, the oxygen 
scavenging device comprising: 
a stopper configured to be removably coupled to the vessel to seal an interior of the vessel, the 
stopper including structure defining an internal channel, the channel having a first end and a second 
end, the channel being in fluid communication with the headspace of the vessel when the stopper is 
coupled to the vessel; and 
an oxygen scavenging agent fluidly coupled to the first end of the channel, the oxygen 
scavenging agent being in fluidic contact with a headspace of the vessel via the channel when the 
oxygen scavenging device is coupled to the vessel to scavenge oxygen therefrom, wherein the oxygen 
scavenging agent is contained within a sachet.
Patent AU-2020280439-A1 (AU)
Title: Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
Inventor: ZHANG HONGYAN
IPC: A61K31/713
Filed: 2020-05-21
Abstract: An siRNA which inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression, a pharmaceutical composition containing the siRNA, and a conjugate. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The siRNA contains a sense strand and an antisense strand. The sense strand contains nucleotide sequence I, nucleotide sequence I having the same length as the nucleotide sequence shown in SEQ ID NO: 1, with no more than three nucleotide differences. The antisense strand contains nucleotide sequence II, nucleotide sequence II having the same length as the nucleotide sequence shown in SEQ ID NO: 2, with no more than three nucleotide differences. The siRNA, the pharmaceutical composition thereof and the conjugate can effectively treat and/or prevent hypercholesterolemia.
Patent AU-2020281762-A1 (AU)
Title: Rapid and deterministic generation of microglia from human pluripotent stem cells
Inventor: PAWLOWSKI MATTHIAS
IPC: C12N5/079
Filed: 2020-05-27
Abstract: The present invention relates to a method for the production of microglia from stem cells comprising the steps of a) targeted insertion of a nucleotide sequence encoding a transcriptional regulator protein into a first genomic safe harbour site; and b) targeted insertion of the coding sequence of the transcription factor PU.1 (SEQ ID NO: 1) into a second genomic safe harbour site, wherein the gene is operably linked to an inducible promoter, which is regulated by the transcriptional regulator protein; expression of PU.1 (SEQ ID NO: 2); and culturing the stem cells received from steps a) and b) with exposure to at least one growth factor or small molecule that mimics signaling during at least one stage of embryonic development of microglia or adult microglia proliferation, differentiation or polarization. Further, the present invention relates to the microglia obtained by the methods of the present invention and various uses thereof.
Patent AU-2020284151-A1 (AU)
Title: Baler with knife protection system
Inventor: VARLEY SEAMUS
IPC: A01F29/22
Filed: 2020-05-27
Abstract: An agricultural machine (1) comprises: a frame (10); a receiver (11), for receiving crops; a pick-up device (12), configured for picking-up the crops from a field; a feeding assembly (13), including a feeding channel (131) and a feeding rotor (132), rotating in a feeding direction (F), to push the crops; a cutting assembly (14), which is configured to cut the crops passing through the feeding channel (131). The cutting assembly (14) includes: a plurality of knives (141), each one pivoting around a respective knife rotation point (142), between an extracted position (E) and a retracted position (R); for each knife of the plurality (141) of knives, a knife protection system (15), configured to retract the respective knife (141), selectively with respect to the other knives of the plurality (141) of knives, in response to an external force (FE) applied to the respective knife (141). For each knife protection system (15), in the extracted position (E) of the knife (141), the driving point (DP) is spaced from the knife rotation point (142) of a first distance, and, in the retracted position (R) of the knife (141), the driving point (DP) is spaced from the knife rotation point (142) of a second distance. The second distance is smaller than the first distance.