Patent SG-11201908994R-A (SG)
Title: Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
Inventor: WARDELL SETH
IPC: C12M1/04
Filed: 2018-01-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT onion °nolo OH 1101 H mum° oimIE (10) International Publication Number WO 2018/182817 Al (51) International Patent Classification: C12N 5/0783 (2010.01) C12M 1/04 (2006.01) (21) International Application Number: PCT/US2018/012633 (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/478,506 62/539,410 62/548,306 62/554,538 62/559,374 62/567,121 62/577,655 62/582,874 62/596,374 05 January 2018 (05.01.2018) English English Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) 29 March 2017 (29.03.2017) US 31 July 2017 (31.07.2017) US 21 August 2017 (21.08.2017) US 05 September 2017 (05.09.2017) US 15 September 2017 (15.09.2017) US 02 October 2017 (02.10.2017) US 26 October 2017 (26.10.2017) US 07 November 2017 (07.11.2017) US 08 December 2017 (08.12.2017) US Applicant: IOVANCE BIOTHERAPEUTICS, INC. [US/US]; 999 Skyway Road, Suite 150, San Carlos, CA 94070 (US). Inventors; and Applicants: WARDELL, Seth [US/US]; 30204 USF Hol- ly Drive, Tampa, FL 33620 (US). BENDER, James [US/US]; 3 Cloverdale, Rancho Santa Margarita, CA 92688 (US). LOTZE, Michael, T. [US/US]; 5134 Westminster Place, Pittsburgh, PA 15232 (US). Agent: MACDOUGALL, Christina, A. et al.; Morgan, Lewis, & Bockius LLP, One Market, Spear Tower, San Fan- cisco, CA 94105 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, N GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, co co (54) Title: PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IM- MUNOTHERAPY 00 (57) : The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic O populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as C well as decreased costs. Such TILs fmd use in therapeutic treatment regimens.