baber/WOPTO huggingface dataset:
Patent AU-PR540301-A0 (AU)
Title: A method of purification of cells
IPC: A61P25/00
Filed: 2001-06-01
Abstract: The present invention relates generally to a method for the generation of a substantially homogeneous population of undifferentiated cells. More particularly, the present invention relates to the purification of a substantially homogeneous population of stem cells and their progenitor or precursor cells. Even more particularly, the present invention provides a population of neural stem cells (NSCs). The subject invention is particularly directed to NSCs and precursor cells with the capacity to differentiate into cells and cell lineages required for the development, maintenance or repair of the central nervous system in an animal such as a mammal. The present invention is further directed to NSCs and progenitor and/or precursor cells which are capable of proliferation and differentiation into multiple cell lineages, such as but not limited to neurons, oligodendrocytes, glia and astrocytes. The subject invention further contemplates the use of NSCs and/or precursor cells for the repair or regeneration of tissue, such as tissue associated with the central nervous system, in an animal including a mammal. The NSCs of the present invention may be used to identify naturally occurring molecules such as cytokines as well as molecules obtained from natural product screening or screening of chemical libraries which induce proliferation of the NSCs. Such molecules are useful in the development of therapeutics.
Patent FI-20040207-A0 (FI)
Inventor: PILTONEN HARRI
IPC: H01Q1/08
Filed: 2004-02-11
Abstract: The invention relates to a directional antenna mechanism of a mobile radio tracking receiver, comprising four antenna elements (12), which are fastened by a pivot pin (14) to the body (10) of the radio tracking receiver. For the duration of the use, the antenna elements are turned to an operating position, in which they are pointed away from the body. After use, the antenna elements can be turned to a transport position, in which the antenna elements are placed inside the body in the direction of the longitudinal axis of the body. In the invention, at least two antenna elements are connected to each other by a mechanism in a way that moving the first antenna element to the operating position or the transport position also causes the second antenna element to move to the same position simultaneously. Preferably, all the antenna elements are connected to each other by a mechanism in a way that moving one antenna element to the operating position or the transport position causes all the antenna elements to move to a corresponding position simultaneously. The mechanism according to the invention comprises a movable transmission rod (16) arranged inside the body, with toothings (26) and toothed discs (22) fastened to the ends of the antenna elements, contacting to the toothings of the transmission rod. The transmission rod is moved either manually by a lever (28) fastened to the transmission rod or by an actuator, such as an electric motor, arranged inside the body. <IMAGE>
Patent FI-20060486-A0 (FI)
Inventor: LEE KUN-HUNG
IPC: H04M/
Filed: 2006-05-18
Abstract: A communication system, a method for extending stand-by time, and a computer readable medium therefor are provided. The communication system includes a mobile communication apparatus and a core network. The method and the computer readable medium therefor perform the following steps. When the mobile communication apparatus is in a low battery situation or required to enter a power saving mode by a user, it sends a signal to the core network to request to enter the power saving mode. After receiving the signal, the core network reduces a data quantity transmitted to the mobile communication apparatus, and thereby the purpose of extending stand-by time is achieved.
Patent IL-101648-A0 (IL)
Title: Bradykinin antagonist peptides
IPC: C07K7/18
Filed: 1992-04-19
Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention further includes the intermediate compounds and additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
Patent IL-107560-A0 (IL)
Title: Kit for preparing radiopharmaceutical compositions containing a technetium-99m complex
IPC: A61K51/00
Filed: 1993-11-10
Abstract: The invention relates to a technetium-99m complex of the general formula    <IMAGE>  (I)  wherein Z is a sulphur atom or an amino group of the general formula R17-N-(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1-R16; each of the symbols R1-R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkly group having 0-4 carbon atoms; and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom; Tc represents technetium-99m; t is 0 or 1; and n is 0 or 1; with the provisos that (a) if R15, R16, R17 and/or R18 are/is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms; (b) at least one of the symbols R1-R18 is ACOOH; and (c) if t is 1, at least two of the symbols R1-R18 are ACOOH; or a pharmaceutically acceptable salt of this compound. The invention further relates to a radiopharmaceutical composition comprising said complex, to the use of this composition for examining the renal function, and to a kit for preparing such a composition.
Patent IL-113307-A0 (IL)
Title: Saf promoter and expression method for expressing foreign dna sequences in streptomyces
IPC: C12R1/465
Filed: 1990-05-17
Abstract: The cloning and characterization of a newly isolated gene, referred to as saf (secondary metabolism activation factor) is disclosed. This gene encodes a new amino acid polypeptide, referred to as the SAF polypeptide, which directly or indirectly modulates the expression of extracellular enzymes in Streptomyces. DNA units or fragments which encode the SAF polypeptides are also disclosed, as are vectors containing said DNA, host organisms transformed with such vectors, and processes for preparing extracellular enzymes or heterologous polypeptides by culturing such host organisms.
Patent IL-116557-A0 (IL)
Title: Antiherpes peptidomimetic compounds their preparation and pharmaceutical compositions containing them
IPC: C07C273/18
Filed: 1995-12-26
Abstract: Disclosed herein are compounds of formula (1), wherein R<1> is (1-3C)alkyl, R<2> is hydrogen or (1-3C)alkyl and R<3> is (1-3C)alkyl, or a therapeutically acceptable salt thereof. The compounds are useful for treating herpes infections.
Patent IL-123500-A0 (IL)
Title: Composite biomaterials for preventing post-surgical adhesions of tissues
IPC: A61L31/10
Filed: 1996-08-29
Abstract: A composite biomaterial (I) for preventing surgical tissue adhesions comprises at least one hyaluronic acid (HA) deriv. selected from (a) benzyl esters of HA in which 75-100% of the COOH gps. of HA are esterified with benzyl and up to 25% are esterified with 10-20C alkyl, provided that at least 80% of the COOH gps. are esterified; and (b) self-crosslinked HA derivs., in which 0.5-20% of the COOH gps. of HA are crosslinked to OH gps. of the same or different HA molecules. Also claimed is the use of (I) for preventing surgical adhesions and a method for preventing tissue adhesions using (I).
Patent IL-132708-A0 (IL)
Title: Packaging method and apparatus
IPC: B65B31/02
Filed: 1999-11-02
Abstract: A method for packaging a product in a hermetically sealed container having a cup-shaped rigid or semi-rigid body with a rim fitted with a closure, the method comprising introducing the product into the cup-like shaped body. Forming an isolated space with a gas inlet and a gas outlet, the space defined between the body and a closure-forming member adjacent to and with a clearance from the rim. Introducing a replacement gas through the inlet to replace at least a substantial portion of gas originally contained in the isolated space, and displacing at least one of the body or the closure-forming member towards the other of the two members to close the clearance and to attach the closure-forming member to the rim, and hermetically attaching the two to one another to form a gas-tight steel.
Patent IL-135319-A0 (IL)
Title: Apolipoprotein a-i agonists and their use to treat dyslipidemic disorders
IPC: A61P3/06
Filed: 1998-09-28
Abstract: The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or diluent are also provided. These pharmaceutical are useful to treat a variety of disorders associated with dyslipidemia.
Patent IL-137138-A0 (IL)
Title: Process for the preparation, preferably from waste materials, of silicate foam with closed pores and the product produced by the process
IPC: C03C11/00
Filed: 1999-03-05
Abstract: The process of the invention characterized in that to 100 parts by weight of a silicate powder having 2000-8000 m2/g specific surface, 1-10 parts by weight of gas-forming material with particle size of 10-100 mum and 0.5-15 parts by weight of montmorillonite, 0.5-2 parts by weight of alkali hydrogen phosphate or alkali dihydrogen phosphate or a mixture of alkali metal phosphate and sodium silicate in form of aqueous solution, 0.01-5 parts by weight of rare earth metal oxide or a mixture of such oxides were added, then the mixture obtained is homogenized, pre-dried, coated with 1-5 parts by weight of titanium oxide and/or titanium oxide hydroxide and/or aluminum oxide hydroxide, then subjected to heat treatment at 720-1000° C., and the mixture obtained is molded. The subject of the invention: also the product of the above process.
Patent IL-158555-A0 (IL)
Title: Human breast milk lipid mimetic as dietary supplement
IPC: A23C11/00
Filed: 2003-10-22
Abstract: The invention provides an enzymatically-prepared fat base composition which comprises a mixture of vegetable-derived triglycerides. The fat base composition has a total palmitic acid residues content of at most 38% of the total fatty acid residues, and at least 60%, preferably 62% of the fatty acid moieties at the sn-2 position of the glycerol backbone are palmitic acid residues, at least 70% of the fatty acid moieties at the sn-1 and sn-3 positions of the glycerol backbone are unsaturated, at least 40%, preferably 40-60%, of the unsaturated fatty acid moieties at the sn-1 and sn-3 positions are oleic acid moieties, and at least 6%, preferably 6-17%, of the unsaturated fatty acid moieties at the sn-1 and sn-3 positions are linoleic acid moieties. The invention also provides preparation and various uses of the fat base composition in the field of infant nutrition.
Patent IL-164389-A0 (IL)
Title: Methods and compositions for killing spores
IPC: A01N63/50
Filed: 2003-04-25
Abstract: The invention provides a sporocidal composition comprising a laccase or a compound exhibiting laccase activity, a source of oxygen, a source of iodide ions and an enhancing agenL A method of killing or inactivating spores and a method of decontaminating a location, which has been exposed to spores, are also disclosed.
Patent IL-172358-A0 (IL)
Title: Colchicoside analogues
IPC: A61K31/704
Filed: 2005-12-05
Abstract: The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
Patent IL-178720-A0 (IL)
Title: Method and apparatus for programably treating water in a water cooler
IPC: B67D7/76
Filed: 2006-10-18
Abstract: An apparatus for a programmable self sanitizing water dispenser apparatus with a digital computer as well as a programmable method for generating ozone for cleaning the reservoir and the water contained within it.
Patent RO-135913-A0 (RO)
Title: Footwear with thick high heel
Inventor: INVENTATORI NEDECLARAŢI
IPC: A43B21/36
Filed: 2021-06-24
Abstract: The invention relates to a footwear article with a thick and high heel, which gives the appearance of a stiletto heel, with a structure of nail-shaped heel of variable height. According to the invention, the footwear article is made up of an insole (1), an upper part (2) which can have various configurations, such as a sandal, a closed shoe or a shoe without a heel counter stiffener, a metal shank (3), a heel (6), a sheep skin (11) and a sole (4) which is applied on the insole (1) up to the heel (6) which is arranged directly on the insole (1) and ends at the back with a cloth (5) which covers the two ends of the lining (8) of the heel (6).
Patent IE-910277-A1 (IE)
Title: Molecules with antibody combining sites that catalyze¹hydrolysis reactions
IPC: C07C229/54
Filed: 1991-01-25
Abstract: An antibody molecule or molecule containing antibody combining site portions (catalytic molecule) that catalytically hydrolyzes a preselected carboxylic acid amide or ester bond of a reactant ligand, methods of making and using the catalytic molecule, and cells that produce those molecules are disclosed. The catalytic molecules bind to a reactant ligand containing the bond to be hydrolyzed and also to a haptenic ligand. The haptenic ligand is structurally analogous to the reactant ligand and contains a tetrahedral carbon atom that is bonded to a hydroxyl group and to a saturated carbon atom at a position in the haptenic ligand that corresponds to position of the carbonyl group and its bonded heteroatom of the reactant ligand. The haptenic ligand also contains a group that bears an ionic charge in aqueous solution at physiological pH values that is not present at a corresponding position of the reactant ligand. The ionic charge-bearing group is located in the hapten within 7  ANGSTROM ngstroms of the tetrahedral carbon atom.
Patent IE-20000331-A1 (IE)
Title: Humanized Immunoglobulins and their production and use
Inventor: SELICK HAROLD E
IPC: C07K16/46
Filed: 1989-12-28
Abstract: The invention provides, inter alia, the use of first nucleotide sequences coding for framework regions from human acceptor Ig light and heavy chains and second nucleotide sequences coding for CDR's from a donor Ig in the production of expressible polynucleotides which encode a humanized immunoglobulin; which immunoglobulin is one obtainable by a method comprising: (a) comparing the framework or variable region amino acid sequences of the donor Ig light and heavy chains with corresponding sequences in a collection of human Ig chains;(b) selecting, to provide the human acceptor Ig light and heavy chain frameworks, sequences from the collection which have at least 65% identity with the respective donor framework sequences; and (c) combining CDR's from the donor Ig and frameworks from the selected acceptor sequences. The invention further includes the provision of humanized immunoglobulin, and in another aspect provides a method of designing a humanized immunoglobulin (Ig) chain having one or more CDR's from a donor Ig and a framework regions from a human Ig, said method comprising: comparing the framework or variable region amino acid sequence of the donor Ig light or heavy chain with corresponding sequences in a collection of human Ig chains; and selecting to provide the human Ig light or heavy chain framework one of the 3-5 most homologous sequences from the collection.
Patent IE-900569-A1 (IE)
Title: Window with an externally positioned, dismantleable glass¹retaining strip
IPC: E06B3/00
Filed: 1990-02-15
Abstract: Window with a window profile and at least one glass plate, as well as adismantleable glass retaining strip arranged on the outside of said glass plate and which is detachably locked to the window profile, characterized in that between the glass stop (6) of the window profile (2), the glass retaining strip (4) and the glass plate (8) is provided at least one glass plate securing element (10) with at least two legs (10a, 10b) , in which one leg (10a) engages behind the outside of the glass plate (8) and at least one further leg (10b) is detachably secured in the window profile (2).
Patent LU-73013-A1 (LU)
IPC: E05D15/48
Filed: 1975-07-18
Abstract: 1485043 Alternative motion windows J H BIERLICH 18 July 1975 [19 July 1974] 32163/74 Heading E1J An alternative motion window assembly comprises a sash 1 coupled to members 7, 9 by hinges 10, 11. The members -7, 9 arecoupled to the jambs 13, 14 by studs 15, 16 and slots 17, 18 and by stays 19, 20 which are pivotally connected 22 to the jambs and by sliding pivots 23 to the members. The locking mechanism located in the sash comprises a handle 28, straight bolts 30, 31 and curved bolts (54, 55). In the first position of the handle. the bolts 30, 31 project and bolts (54, 55) are withdrawn; in the second position of the handle the bolt positions are reversed. Bolts 30, 31 engage the upper rail of the main frame and bolts (54, 55) engage the insets 60, 61 locking members 7, 9 to the sash. Pegs 24, 25 on the lower rail engage sockets 24a, 25a on the sash. With the sash closed and the handle in the first position the window is locked; moving the handle to the second position allows the sash to be opened to the ventilating position Fig. 2; returning the handle to the first position permits the sash to be reversed for cleaning Fig. 3.
Patent MA-27075-A1 (MA)
Title: Formulations pharmaceutiques pour la liberation controlee de la 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl) - quinazoline
Inventor: JOHN DOUGLAS DAVIS
IPC: A61K9/22
Filed: 2004-04-08
Abstract: DEPOSANT Société dite: PFIZER INC. REVENDICATION DE PRIORITES GB 11 Octobre 2001 0124455.7 Voir en annexe le titre de l'invention et le texte de l'abrégé Formulations pharmaceutiques pour la libération contrôlée de la 4-amino-6,7-diméthoxy-2-(5-méthanesulfonamido-1,2,3, 4-tétrahydroisoquinol-2-yl)-5-(2-pyridyl)-quinazoline La présente invention propose une formulation pharmaceutique à libération contrôlée pour administration orale, comprenant de la 4-amino-6,7-diméthoxy-2-(5-méthanesulfonamido-1,2,3,4-tétrahydroisoquinol-2-yl)-5-(2-pyridyl)-quinazoline, ou un de ses sels pharmaceutiquement acceptables, et un adjuvant, diluant ou support pharmaceutiquement acceptable, ladite formulation étant caractérisée en ce qu'elle est adaptée a libérer au moins 50 % en poids de la 4-amino-6,7-diméthoxy-2-(5-méthane-sulfonamido-1,2,3,4-tétrahydroisoquinol-2-yl)-5-(2-pyridyl)-quinazoline, ou de son sel pharmaceutiquement acceptable, au bout de 6 heures dans l'Appareil 1 décrit dans la Pharmacopée des Etats-Unis d'Amérique 24 (2000), pages 1941-1943, comprenant des récipients de 1 litre, des paniers à mailles no. 40 (ouvertures de 0,4 mm), à une vitesse de rotation de 100 tr/min, et avec un milieu de dissolution consistant en 900 ml d'acide chlorhydrique 0,01 M contenant 0,7 % en poids / volume de chlorure de sodium à 37o.C. Les formulations conformes à la présente invention conviennent au traitement de l'hyperplasie prostatique bénigne (HPB).
Patent MA-40291-A1 (MA)
Title: Aimant à base de nanoparticules de ferrite spinelle
Inventor: HAMEDOUN MOHAMMED
IPC: H01F1/34
Filed: 2017-05-05
Abstract: La présente invention concerne la fabrication d’un matériau composite à base de ferrite spinelle et hexaferrites ayant une valeur bhmax avoisinant celle obtenue par les terres rares. Des matériaux à bases de ferrite a1-xfe2+xo4 et composites de ferrite-hexaferrites (a1- xfe2+xo4 + y%bfe12o19 avec 1
Patent UY-27854-A1 (UY)
Title: Preparaciones acidas de insulina con estabilidad mejorada
Inventor: BRUNNER-SCHWARZ DR ANETTE
IPC: A61K47/36
Filed: 2003-06-16
Abstract: Preparaciones ácidas de insulina con estabilidad mejorada. La invención se refiere a una formulación farmacéutica que comprende un polipé´tido seleccionado de un grupo que comprende insulina, un metabolito de insulina, un análogo de insulina, un derivado de insulina o combinaciones de los mismos; un tensioactivo o combinaciones de dos o más tensioactivos; opcionalmente, un conservante o combinaciones de dos o más conservantes; y, opcionalmente, un agente de isotonía, tampones u otros excipientes adicionales, o combinaciones de los mismos, teniendo la formulación farmacéutica un pH en el intervalo ácido.
Patent UY-29057-A1 (UY)
Title: Derivados de triazolopiridinilsulfanilo como inhibidores de quinasa map p38
Inventor: LEWTHWAITE RUSSELL ANDREW
IPC: A61K31/4155
Filed: 2005-08-11
Abstract: Un compuestos de fórmula (I), o una sal y/o solvato (incluyendo un hidrato) farmacéuticamente aceptable del mismo; y el uso de un compuesto de fórmula (I) en el tratamiento de una enfermedad, trastorno o afección mediada por TNF, o una enfermedad, trastorno o afección mediada por p38, en particular las enfermedades alérgicas y no alérgicas de las vías respiratorias, más particularmente enfemedades obstructivas o inflamatorias de las vías respiratorias, preferiblemente la enfermedad pulmonar obstructiva crónica.
Patent UY-29123-A1 (UY)
Title: Compuestos de 4-amino-sustituido-2-sustituido-1,2,3,4-tetrahidroquinolina
Inventor: SHANKER RAVI MYSORE
IPC: C07D257/06
Filed: 2005-09-20
Abstract: Compuestos de 4-amino sustituido-2-sustituido-1,2,3,4-tetrahidroquinolina, composiciones farmacéuticas que contienen tales compuestos y el uso de tales compuestos para elevar determinados niveles de lípidos en plasma, incluido lipoproteínas de alta densidad-colesterol, y para disminuir determinados otros niveles de lípidos en el plasma, tales como LDL-colesterol y triglicéridos y, por consiguiente, para tratar enfermedades que están excerbadas por bajos niveles de HDL-colesterol y/o altos niveles de LDL-colesterol y triglicéridos, tales como aterosclerosis y enfermedades cardiovasculares en algunos mamíferos, incluídos seres humanos.
Patent CH-714542-A1 (CH)
Title: Sicherheitsnetzwerk und Sicherheitssensor.
Inventor: ROMAN STEINER
IPC: H04L12/40
Filed: 2018-01-09
Abstract: Dargestellt und beschrieben ist ein Sicherheitsnetzwerk mit mehreren Sicherheitssensoren (21, 21´, 21´´, 21´´´), welche über einen ersten und über einen zweiten Datenbus (23, 25) miteinander verbunden sind, wobei der erste Datenbus (23) für die Übertragung von nicht-sicherheitsrelevanten Daten ausgebildet ist und der zweite Datenbus (25) für die Übertragung von sicherheitsrelevanten Daten ausgebildet ist. Ausserdem ist vorgesehen, dass wenigstens einer der Sicherheitssensoren eine Schnittstelle zu einem dritten Datenbus (31) aufweist und mit diesem verbunden ist, wobei der Datenbus (31) dazu ausgebildet ist, eine fehlersichere Übertragung von Daten von diesem Sicherheitssensor an ein Steuergerät sicherzustellen.
Patent ES-184289-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN DE DISAZOCOLORANTES CONTENIENDO COBRE
Filed: 1948-06-25
Abstract: Procedimiento para la obtención de disazocolorantes conteniendo cobre caracterizado esencialmente por el hecho de hacer reaccionar con disazocolorantes de **(ver fórmula)** en la cual significan R un radical difenilo engarzado en posición -4 y -4' a los grupos azo el cual lleva en posición -3 y -3' sendos grupos alcoxi y R1 el radical de un ácido 1 8-dioxinaftalin-sulfónico engarzado en posición -2 al grupo azo medios que ceden cobre hasta que los grupos alcoxi hayan quedado disociados.