baber/WOPTO huggingface dataset:
Patent CA-3050332-A1 (CA)
Title: Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor
Inventor: CARDILLO THOMAS M
IPC: C07K16/30
Filed: 2018-03-20
Abstract: The present invention relates to treatment of Trop-2 postive cancers with the combination of anti-Trop-2 ADC and a Rad51 inhibitor. Preferably the drug conjugated to the antibody is SN-38, and the ADC is sacituzumab govitecan. The ADC may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg. When administered at specified dosages and schedules, the combination of ADC and Rad51 inhibitor can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the combination is effective to treat cancers that are refractory to or relapsed from irinotecan or topotecan.
Patent CA-3050679-A1 (CA)
Title: Psilocybin and/or psilocin in combination with cannabinoids and/or terpenes
Inventor: KUCUKSEN MURAT
IPC: A61K31/404
Filed: 2018-01-18
Abstract: The present invention relates to the use of one or more cannabinoids and/or terpenes in combination with psilocybin and/or psilocin for use in the prevention or treatment of psychological or brain disorders. Preferably the one or more cannabinoids are taken from the group cannabidiol (CBD); cannabidiolic acid (CBDA); tetrahydrocannbidivarin (THCV); tetrahydrocannbidivarinin acid (THCVA); cannabichromene (CBC); cannabichromenic acid (CBCA); cannabigerol (CBG) and cannabigerolic acid (CBGA).
Patent CA-3053939-A1 (CA)
Inventor: NISTOR GABRIEL
IPC: C07K14/47
Filed: 2018-02-16
Abstract: La présente invention concerne des méthodes destinées à accroître la teneur antigénique, en particulier en antigènes associés aux tumeurs (TAA), et l'immunogénicité des cellules cancéreuses ; des méthodes destinées à améliorer la présentation croisée dans les cellules dendritiques, des compositions contenant lesdites cellules manipulées dérivées de patients individuels atteints de cancer ; et des procédés d'utilisation desdites compositions à titre de produit immunothérapeutique personnel pour traiter le cancer du patient donneur.
Patent CA-3053956-A1 (CA)
Inventor: GEIER MICHAEL
IPC: A61P3/00
Filed: 2018-03-02
Abstract: The present disclosure provides solid forms, including a salt or co-crystal, of Compound I which exhibits Acetyl-CoA carboxylase ("ACC") inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
Patent CA-3056023-A1 (CA)
Title: Tamping unit for tamping sleepers of a track
Inventor: MATZINGER NIKOLAUS
IPC: E01B27/16
Filed: 2018-04-05
Abstract: The invention relates to a tamping unit (1) for tamping sleepers (2) of a track (3), comprising a lowerable tool holder (4) and tamping tools (5) lying opposite one another, each tamping tool (5) being connected by a pivot arm (6) to a squeeze drive (7) in order to produce a squeezing action and to an electric vibratory drive (8) in order to produce a vibratory action. The electric vibratory drive (8) comprises an eccentric shaft (14) which is mounted together with a rotor (21) of an electric motor (22) exclusively in an eccentric housing (12), and a stator (24) of the electric motor (22) is flange-mounted by a motor housing (11) to the eccentric housing (12).
Patent CA-3056651-A1 (CA)
Inventor: DADKHAH TEHRANI MOHAMMAD
IPC: C09J9/00
Filed: 2018-03-16
Abstract: Provided are systems and methods for the post-treatment of dry adhesive microstructures. The microstructures may be post-treated to comprise mushroom-like flaps at their tips to interface with the contact surface. In some aspects, a change in material composition of the microstructures in a dry adhesive may affect mechanical properties to enhance or diminish overall adhesive performance. For example, conductive additives can be added to the material to improve adhesive performance. In other aspects, microstructures comprising conductive material may allow for pre-load engagement sensing systems to be integrated into the microstructures.
Patent CA-3057029-A1 (CA)
Inventor: REYNOLDS AARON
IPC: A47K5/12
Filed: 2009-12-28
Abstract: Une méthode pour établir et contrôler les paramètres de fonctionnement dun distributeur qui utilise des cartouches contenant du matériel à distribuer comporte les étapes suivantes : installer une première cartouche pour la première fois dans le distributeur; permettre un mode dapprentissage à un contrôleur de distributeur; lire des données dune première étiquette sur la première cartouche; déterminer au moins un paramètre de fonctionnement de la première étiquette; stocker le ou les paramètres de fonctionnement de la première étiquette; installer une deuxième cartouche dans le distributeur; lire des données dune deuxième étiquette de la deuxième cartouche; permettre le fonctionnement du distributeur avec la deuxième cartouche si un paramètre de fonctionnement déterminé dans les données lues de la deuxième cartouche correspond à au moins un du ou des paramètres de fonctionnement stockés dans le distributeur; et contrôler lopération du distributeur conformément à au moins un des paramètres de fonctionnement stockés dans le distributeur.
Patent CA-3060001-A1 (CA)
Title: Improved use of the residual gas from a pressure swing adsorption plant
Inventor: LEITMAYR WERNER
IPC: C01B3/34
Filed: 2018-04-27
Abstract: The invention relates to a process for providing a fuel gas (4) which is generated at regeneration pressure as residual gas (3) during the regeneration of a pressure swing adsorption plant (D) used for fractionation of synthesis gas (1) and after an intermediate storage in a buffering vessel (P) is passed through a control valve (Z1) in order to be passed to a burner (B) with a controlled mass flow. The characterizing feature here is that by specification of a manipulated variable (8) determined by the load on the pressure swing adsorption plant (D) the control valve (Z1) is positioned at an operating point wherein the pressure in the buffering vessel (P) is in a defined range.
Patent CA-3061687-A1 (CA)
Title: Beverage preparation machine with capsule recognition
Inventor: GUYON BERTRAND
IPC: A47J31/44
Filed: 2018-06-13
Abstract: A machine (1) for preparing and dispensing a beverage (2) has: a capsule extraction unit (10) having a first part (11) and a second part (12) that are relatively movable between a distant position for inserting a capsule (3) and a close position for extracting such capsule (3); a control unit (40) for controlling the extraction unit (10) to extract such capsule (3); an outlet (20) for dispensing said beverage (2) formed by extracting such capsule (3) to a user- receptacle (4) located in a receptacle placing area; and a capsule recognition arrangement (30) connected to the control unit (40) for recognizing the colour of at least part of a capsule inserted in the machine (1).
Patent CA-3064211-A1 (CA)
Inventor: SU WEN-HONG
IPC: A01K63/06
Filed: 2019-12-08
Abstract: A glass-tube heater includes a glass tube, a cap, and a temperature display unit. The glass tube is provided therein with an off-water protection sensor or a tipping switch, a control circuit board, one of a TRIAC and a relay, and a heating element. The control circuit board includes a control unit (which is an MCU or a comparator). All the components that are disposed in the glass tube are electrically connected to form a control circuit. Devices for temperature control, detection, and heating are all disposed inside the glass tube. The off-water protection sensor is operable to detect if being removed out of water for controlling the heating element to carry out heating or not, thereby ensuring quick termination of heating upon removal out of water. The tipping switch is operable to control the heating element from heating in case of excessive tipping of the heater.
Patent CA-3064426-A1 (CA)
Title: Food and drink holder
Inventor: JAECKEL DAVID
IPC: A47G23/06
Filed: 2018-05-22
Abstract: In one embodiment of the invention, a food and drink holder configured to be removably mounted to a cup holder attached to seats or an arm rest is provided that includes a drink receptacle. The drink receptacle includes a generally cylindrical sidewall having a central axis, and the sidewall is configured to be removably mounted in an opening in the cup holder. The food and drink holder also includes a food receptacle having a pair of sidewalls, a front wall, an end wall, a bottom wall, and a top end.
Patent CA-3067221-A1 (CA)
Title: Colorimetric sensors and methods of manufacturing the same
Inventor: HU MIN
IPC: G01N21/45
Filed: 2018-06-13
Abstract: A colorimetric sensor for detecting an analyte of interest that includes multiple surfaces and a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. Each surface defines a void (e.g., a pore or a nanohole) and at least one surface defines a fluid inlet. The sensor is configured such that, when an analyte contacts the molecularly imprinted polymer and becomes disposed within the cavity, a wettability of at least one of the surfaces changes thereby to cause a detectable color change in the sensor. Optionally, the sensor may also include a metal layer at a bottom of each void or nanohole and outside a top of each void or nanohole for use as a plasmon resonance-type sensor.
Patent CA-3071832-A1 (CA)
Title: Irradiation par isotopes de canal de combustible a pleine puissance de fonctionnement
Inventor: FISHER BENJAMIN D
IPC: G21C23/00
Filed: 2018-08-02
Abstract: Cette invention concerne un procédé d'irradiation d'un matériau cible dans un réacteur à eau lourde pour la production d'un isotope, comprenant les étapes consistant à fournir une cible composée d'un matériau approprié pour produire l'isotope au moyen d'un événement de capture de neutrons, placer la cible dans un côté fluide primaire du réacteur à eau lourde, et irradier la cible.
Patent CA-3072240-A1 (CA)
Inventor: ZHANG YAMIN
IPC: A61K31/403
Filed: 2018-08-10
Abstract: La présente invention concerne des formes solides de 3-(5-fluorobenzofuran-3-yl)-4-(5-méthyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, leurs procédés de préparation, des compositions pharmaceutiques en comprenant et leurs utilisations dans le traitement de maladies.
Patent CA-3074881-A1 (CA)
Inventor: YANG NING
IPC: H04W16/28
Filed: 2017-09-12
Abstract: Disclosed are an information processing method, a high-level functional entity and a computer storage medium. The method comprises: a high-level functional entity receiving a first pre-set number of pieces of beam recovery failure indication information, and starting a first timer according to the first pre-set number of pieces of beam recovery failure indication information, wherein the first pre-set number is one or at least two.
Patent CA-3076529-A1 (CA)
Title: Circuit d'etage de puissance de carte de calcul, unite de groupe d'alimentation electrique, et carte de calcul
Inventor: CHANG XIN
IPC: H02M3/00
Filed: 2018-09-21
Abstract: Selon des modes de réalisation, la présente invention concerne un circuit d'étage de puissance, un groupe d'alimentation électrique et une carte de calcul. Le circuit d'étage de puissance inclut un circuit d'entrée et un circuit de sortie. Le circuit d'entrée et le circuit de sortie sont connectés électriquement. Le circuit d'étage de puissance inclut également une pluralité de broches de groupe. La pluralité de broches de groupe sont connectées respectivement au circuit d'entrée, au circuit de sortie, et à une unité de groupe d'alimentation électrique.
Patent CA-3077343-A1 (CA)
Inventor: OKANO HIROSHI
IPC: B01J20/34
Filed: 2019-08-02
Abstract: [Problem] The purpose of the present invention is to provide a gas adsorbent that has the capacity to recover carbon dioxide gas at a high yield by the thermal swing method and concentrate the gas to a high level, that has high durability and relatively low pressure loss, that can be reduced in size, and that can be produced at a relatively reduced cost, and a carbon dioxide concentration device. [Solution] The present invention relates to a laminate adsorbent comprising a particle-like adsorbent material adhesive sheet and a carbon dioxide gas recovery/concentration device using the adsorbent. The carbon dioxide gas recovery/concentration device can solve the drawbacks of filled layers of fixed bed, moving bed and fluidized bed types and the high cost of a honeycomb rotor type while simultaneously having the characteristics of these types. Additionally, this device adsorbs carbon dioxide gas in a state where the adsorbent is wet, thereby remarkably enhancing adsorption capacity due to the evaporative cooling effect of water. Desorption is achieved by regenerative desorption using low-temperature saturated steam containing carbon dioxide gas and water vapor mixed therein, thereby leading to energy saving.
Patent CA-3083082-A1 (CA)
Title: Paire de ciseaux pour couteau de poche multifonctionnel
Inventor: HUG PETER
IPC: B26B11/00
Filed: 2018-11-06
Abstract: Le couteau de poche multifonctionnel (1) se compose d'un manche (2) formé de deux flancs solidaires (3, 3') ménageant au moins un espace de rangement (4) pour des outils rabattables (6) pivotant chacun autour des axes de liaison (5) respectivement (5') disposés à chaque extrémité du manche (2). L'un des outils (6) consiste en une paire de ciseaux (8) se déployant selon l'axe longitudinal du couteau (1) et se composant de deux lames planes (9, 9') comportant chacune une arrête coupante (10, 10') et pivotant toutes deux autour d'un même axe (5). Paire de ciseaux (8) destinée à être incorporée à un couteau de poche multifonctionnel (1).
Patent CA-3084023-A1 (CA)
Inventor: HAYWOOD JOHN HERBERT
IPC: G01B9/02
Filed: 2018-11-30
Abstract: Disclosed herein is a system (10) for interrogating an interferometer. The system (10) comprises an optical signals generation system (14) for concurrently generating a plurality of optical signals that each have a modulation parameter that the other of the plurality of optical signals d not have. The optical signals generation system (14) is for optically coupling each of the plurality of optical signals to a plurality of optical ports (16, 18, 20) of the interferometer (12) for ingress of the plurality of optical signals into the interferometer (12). The system (10) comprises an interferometer output processing system (22). Also disclosed herein is an interferometric system and a method for interrogating an interferometer
Patent CA-3085221-A1 (CA)
Title: Procedes de traitement de lesions residuelles d'anomalies vasculaires
Inventor: DEKLOTZ CYNTHIA MARIE CARVER
IPC: A61K9/08
Filed: 2018-12-17
Abstract: L'invention concerne des compositions comprenant des acides biliaires ou des sels de ceux-ci, ainsi que des procédés d'utilisation de ces compositions pour le traitement de lésions résiduelles d'anomalies vasculaires.
Patent CA-3086262-A1 (CA)
Inventor: BRAUN MARTIN
IPC: A61K39/085
Filed: 2018-12-19
Abstract: The present invention discloses modified Staphylococcus aureus HIa proteins which show reduced tendency to aggregate, improving protein stability and yield. Said modified HIa proteins optionally also contain glycosylation site consensus sequences. The invention also discloses a conjugate comprising a modified HIa protein and an antigen (for example a Staphylococcus aureus saccharide antigen), wherein the antigen is linked to an amino acid residue of the modified HIa protein.
Patent CA-3089354-A1 (CA)
Inventor: KALANTARI MASOUD
IPC: E21B43/00
Filed: 2019-01-30
Abstract: A method of optimizing operation one or more tubing strings in a hydrocarbon well, apparatus and system for same. Each tubing string is located in a hydrocarbon well and has a plurality of valves. Each valve is actuatable between a fully open position and a fully closed position, and is in communication with a respective zone of a formation defining a reservoir containing hydrocarbon material. The method comprises: characterizing an injectivity of one or more zones of the formation in accordance with pressure data associated with each of the one or more zones of the formation; and determining an optimal operating schedule in accordance with the characterization of the one or more zones of the formation and one or more performance objectives, wherein the optimal operating schedule comprises one or more valve configurations and an operating duration for each of the one or more valve configurations, wherein each valve configuration is defined by a condition of the valves in which each valve in the plurality of valves is in either the fully open position or the fully closed position.
Patent CA-3090921-A1 (CA)
Title: Pivoting unit for a tracking apparatus for solar modules
Inventor: DECHANT GABRIEL
IPC: F24S30/425
Filed: 2018-03-23
Abstract: The present invention relates to a pivoting unit (10) for a tracking apparatus (NV) for solar modules (20), comprising: at least one cross member (22) pivotable about a pivot axis (S), at least one drive arch (24), which is connected to the at least one cross member (22) and has a plurality of drive recesses (42) and a plurality of retaining recesses (44), and at least one rotatably mounted drive unit (38), the rotatably mounted drive unit (38) being designed such that it engages in at least one of the drive recesses (42) of the drive arch (24) in order to pivot the at least one cross member (22). The drive unit (38) is designed in such a way that it engages in at least one of the retaining recesses (44) in order to hold the cross member (22) in a pivoted position.
Patent CA-3091669-A1 (CA)
Title: Systemes et procedes de detection d'allergenes
Inventor: GILBOA-GEFFEN ADI
IPC: G01N33/53
Filed: 2019-02-21
Abstract: La présente invention concerne des dispositifs et des systèmes de détection d'allergènes dans des échantillons alimentaires. Le système de détection d'allergènes comprend une cartouche d'analyse jetable et un dispositif de détection avec un système optique optimisé.
Patent CA-3091947-A1 (CA)
Title: Drilling fluid comprising a lubricant
Inventor: DAVIES CRAIG ALLAN
IPC: C09K8/03
Filed: 2019-03-05
Abstract: The present invention provides a drilling fluid comprising a compound c) which comprises a dimer and/or trimer fatty acid residue and an alkyleneoxy chain comprising a first ethyleneoxy section, a second ethyleneoxy section and a propyleneoxy section located between said first and second ethyleneoxy sections, wherein the propyleneoxy section comprises from 1 to 20 propyleneoxy groups. Use of such a drilling fluid to lubricate a drill bit, and a method of drilling a well bore comprising circulating such a drilling fluid, are also provided.
Patent CA-3094305-A1 (CA)
Inventor: CREW ANDREW P
IPC: C07D417/14
Filed: 2019-04-01
Abstract: La présente divulgation concerne des composés bifonctionnels de la structure chimique suivante : dans laquelle PTM, L et ULM peuvent représenter divers groupes utiles comme modulateurs de SMARCA2 ou BRM (protéine cible). Plus précisément, la présente divulgation concerne des composés bifonctionnels qui contiennent, à une extrémité, un ligand se liant à l'ubiquitine ligase E3 de Von Hippel-Lindau et, à l'autre extrémité, un groupe liant la protéine cible, de sorte que cette dernière soit placée à proximité de l'ubiquitine ligase pour influencer la détérioration (et l'inhibition) de la protéine cible. La présente divulgation présente une large gamme d'activités pharmacologiques associées à la détérioration/inhibition de la protéine cible. Les maladies et les troubles découlant du regroupement ou de l'accumulation de la protéine cible sont traités ou prévenus au moyen des composés et des compositions de la présente divulgation.
Patent CA-3095217-A1 (CA)
Inventor: MAACK FRANK
IPC: F24D19/00
Filed: 2019-07-01
Abstract: Specified is a water supply apparatus, a mixing apparatus (1) being provided for mixing, in a mixing container (3), water conveyed in the mixing apparatus (1). Arranged relative to the mixing container (3) is a base apparatus (2) which has a base chamber (9) that is hydraulically connected to a water pipe (11, 12, 13) of the water supply apparatus and has an opening to the surroundings. A sealing device (10) is installed in the base chamber (9) for the purpose of closing off the opening of the base chamber (9) from the surroundings. The sealing device (10) has a weak point wall region (17) whose pressure strength is lower than the pressure strength of wall regions of all the other components of the water supply apparatus which, in the operating state, enclose cavities that can be filled with water, and which separate these cavities that can be filled with water from the surroundings.
Patent CA-3095626-A1 (CA)
Inventor: GANIREDDY GOVARDHAN
IPC: H02M1/12
Filed: 2019-04-04
Abstract: Systems and methods for operating a power system having a doubly fed induction generator are provided. In example implementations, an electrical power system (100) connected to a power grid (190) can include a generator (120) comprising a stator and a rotor, the stator connected to the power grid via a stator power path, and a power converter (130). The power converter (130) can include a line-side converter (134) coupled to the power grid (190) via a converter power path and a rotor-side converter (132) coupled to a rotor bus (124) of the rotor and the line-side converter (134) via a DC link, the rotor-side converter (132) configured to convert a DC power on the DC link to an AC signal for the rotor bus (124). The power system (100) can also include an active filter (250) comprising one or more active controlled components, the active filter (250) being coupled in parallel with the rotor-side converter (132) to reduce harmonics of the electrical power system (100).
Patent CA-3098151-A1 (CA)
Inventor: MADDUX TODD
IPC: C07D413/14
Filed: 2019-05-07
Abstract: La présente invention concerne des depsipeptides cycliques endoparasitiques de formule (1). L1 et L2 sont pareils ou L1 est absent, L1 et L2 sont des cycloalkyles en C1-C4, des aryles en C1-C4, des hétérocycles en C1-C4 ou des hétéroaryles en C1-C4, chacun facultativement substitué, et chacun de R1, R2, R3 et R4 étant séparément et indépendamment sélectionné de H et de l'alkyle en C1-C6 pour le traitement des animaux contre les endoparasitoses.
Patent CA-3099757-A1 (CA)
Title: Modulation de la phagocytose cellulaire dependant de l'anticorps
Inventor: KUHNS SCOTT T
IPC: C07K16/28
Filed: 2019-06-05
Abstract: L'invention concerne des procédés de modulation de l'activité de phagocytose cellulaire dépendant de l'anticorps (AD CP) d'une composition d'anticorps. Dans des modes de réalisation donnés à titre d'exemple, le procédé comprend la modulation de la quantité des (a) glycanes galactosylés de l'anticorps, (b) des glycanes afucosylés de l'anticorps, (c) des glycanes à haute teneur en mannose de l'anticorps, ou (d) d'une combinaison de ceux-ci, pour moduler l'activité de l'ADCP de l'anticorps.