Patent SG-11201407875U-A (SG)
Title: Compostions and methods for cancer immunotherapy
Inventor: DUBENSKY THOMAS W
IPC: A61K39/00
Filed: 2013-06-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185052 Al (51) International Patent Classification: A61P 37/04 ( 2006.01) (21) International Application Number: PCT/US2013/044744 (22) International Filing Date: 7 June 2013 (07.06.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/657,574 8 June 2012 (08.06.2012) US (71) Applicants: ADURO BIOTECH [US/US]; 626 Bancroft Way, Suite 3C, Berkeley, CA 94710-2225 (US). THE JOHN HOPKINS UNIVERSITY [US/US]; 100 North Charles Street, 5th Floor, Johns Hopkins Technology Transfer, Baltimore, MD 21201-3894 (US). (72) Inventors: DUBENSKY, Thomas, W.; 15 King Avenue, Piedmont, CA 94611 (US). LEONG, Meredith, Lia Ling; 6615 Saroni Drive, Oakland, CA 94611 (US). PARDOLL, Drew, M.; 19400 James Creek Court, Brookeville, MD 20833 (US). KIM, Young, Jun; 3302 Governor Carroll Court, Ellicott City, MD 21043 (US). (74) Agents: WHITTAKER, Michael, A. et al.; Acuity Law Group, P.C., 12707 High Bluff Drive, Suite 200, San Diego, CA 92130 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: COMPOSTIONS AND METHODS FOR CANCER IMMUNOTHERAPY (57) Abstract: The present invention provides a combination therapy which relies on a small molecule immune stimulator - cyclic-di-nucleotide (CDN) - that activates DCs via recently a discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and pro­ liferation, coupled with a potent DC activation stimulus. *> Cycllc-dl-GMP C[G(3',5')|jG(3',5')p] c[G(2',5')pA(3',5')p] Fig. 1 Bacteria Protozoa Viruses -5 . CDG „ t s WO 2013/185052 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll llll llll lllll lllll lllllll llll llll u ls e ' — before the expiration of the time limit for amending the — with international search report (Art. 21(3)) claims and to be republished in the event of receipt of amendments (Rule 48.2(h))