baber/WOPTO huggingface dataset:
Patent CR-20150436-A (CR)
Title: Nuevos octahidro-pirrolo[3,4-c]-pirrol y -piridina-fenilo
Inventor: HERT JÉRÔME
IPC: A61K31/5517
Filed: 2015-08-24
Abstract: La invención proporciona nuevos compuestos que tienen la fórmula general (I) en la que R1, Y, A, W, R2, m, n, p y q tienen los significados aquí definidos, composiciones que contienen los compuestos y métodos de uso de los compuestos.
Patent CR-20170022-A (CR)
Title: Anticuerpos biespecíficos anti-il4-il13
Inventor: SOUBRANE CHRISTINA
IPC: A61K39/395
Filed: 2015-06-26
Abstract: En el presente documento se desvelan dosis seguras de proteínas de unión de tipo anticuerpo de doble región Vo fragmentos de las mismas, así como métodos para evaluar la unión de proteínas de tipo anticuerpo de doble región V o fragmentos de las mismas a sus dianas y métodos para tratar la fibrosis pulmonar idiopática (FPI) mediante la administración de dosis seguras de proteínas de unión de tipo anticuerpo de doble región V o fragmentos de las mismas. En algunas realizaciones, las proteínas de unión de tipo anticuerpo de doble región V o fragmentos de las mismas se unen tanto a la IL-4 como a la IL-13.
Patent CR-20190280-A (CR)
Inventor: WAGNER CLAUDIA
IPC: C12N15/09
Filed: 2017-12-06
Abstract: La presente invención se relaciona con cadenas a o ß modificadas de receptor de célula T (TCR), o heterodímeros que comprenden las mismas, en donde en el dominio variable de dicha cadena a o ß modificada, se sustituye un aminoácido en la posición 44 de acuerdo con la numeración de IMGT por otro aminoácido adecuado con el objetivo de mejorar el apareamiento de cadenas deseadas.The present invention relates to modified T cell receptor (TCR) a or ß chains, or heterodimers comprising the same, wherein in the variable domain of said modified a or ß chain, an amino acid at position 44 according to the IMGT numbering is substituted by another suitable amino acid in order to improve pairing of desired chains.
Patent CR-20210026-A (CR)
Title: Crystal modifications of odevixibat
Inventor: BRYLAND RIKARD
IPC: C07D285/36
Filed: 2019-06-20
Abstract: <p>The present invention relates to crystal modifications of 1,1-dioxo-3,3-dibutyl-5-phenyl-7- methylthio-8-(N-{(R)-α-[N-((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)- 2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine (odevixibat), more specifically crystal modifications and 2 of odevixibat. The invention also relates toa process for the preparation of crystal modification 1 of odevixibat, toa pharmaceutical composition comprising crystal modification 1, and to the use of this crystal modification in the treatment of various conditionsas described herein.</p>
Patent EC-SP045241-A (EC)
Title: Producto de inhala­ción en polvo que contiene el antagonista de CGRP, BIBN4096, y procedimiento para su preparación
Inventor: TRUNK MICHAEL
IPC: A61K9/72
Filed: 2004-08-20
Abstract: La invención se refiere a un producto de inhalación en polvo para el tratamiento de la migraña, que abraca el antagonista de CGRP 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihidro-2(1H)-oxoquinazolin-3-il)-1-piperidinil]carbonil]-D-tirosil]-L-lisil]-4-(4-piridinil)-piperazina [BIBN4096] de la fórmula I como base de principio activo en forma de partículas con una nanoestructura esférica, así como a un procedimiento para su preparación.
Patent EC-SP055930-A (EC)
Title: Conjugados polimericos de interferon-beta con potencia biologica aumentada
Inventor: MARTINEZ ALEXA
IPC: A61K47/48
Filed: 2005-07-20
Abstract: Se suministran métodos para la síntesis de conjugados poliméricos de citoquinas y sus antagonistas de unión al receptor, especialmente un interferón-beta no glicosilado, conjugados que retienen una potencia biológica inusualmente elevada. La preparación de conjugados poliméricos de acuerdo con los métodos de la presente invención reduce o evita la inhibición estérica de interacciones receptor-ligando que comúnmente se producen a partir de la unión de polímeros a las regiones de unión al receptor de las citoquinas, como así también a sus análogos agonistas y antagonistas. La invención suministra, además, conjugados y composiciones producidos por tales métodos. Los conjugados de la presente invención retienen un elevado nivel de potencia biológica comparados con los producidos por los métodos tradicionales de acoplamiento de polímeros que no se han orientado para evitar los dominios de unión al receptor de citoquinas. En ensayos in vitro, la potencia biológica de los conjugados de interferón-beta no glicosilado de la presente invención es sustancialmente mayor que la del interferón-beta no conjugado y es similar a la del interferón-beta-1a glicosilado. Los conjugados de la presente invención muestran además mayor vida media in vivo comparados con la correspondiente citoquina no conjugada. La presente invención suministra, además, kits que comprenden tales conjugados y/o composiciones, y métodos de uso de tales conjugados y composiciones en una variedad de aplicaciones diagnósticas, profilácticas y terapéuticas, incluyendo el tratamiento de la esclerosis múltiple.
Patent EC-SP056185-A (EC)
Inventor: KOIVUSAARI RAUNO
IPC: F03B13/14
Filed: 2005-11-24
Abstract: A production installation ( 1 ) for utilizing wave energy in which production installation there are two or more production units ( 4 ) and the water mass (V) of the water basin is adapted to actuate production units ( 4 ) or their parts located at the bottom (P) of the water basin or in close vicinity, and the production units ( 4 ) can be used to transform the kinetic energy of the water mass into some other form of energy like electric energy and/or kinetic energy and/or pressure of the intermediate agent. The production units ( 4 ) are attached directly or indirectly to the bottom of the water basin at intermediate water region (B). The production units ( 4 ) are totally submerged under water surface. The transfer equipment of the energy of the production units ( 4 ) or of the intermediate substance is connected in series or parallel in relation to each other.
Patent EC-SP066582-A (EC)
Title: Sistema integral resistente a la intrusión, provisto con un dispositivo óptico con el objeto de medir remotamente el consumo de energía eléctrica en la red de distribución, y un dispositivo resistente a intrusiones para operar el sistema
Inventor: SAMPAIO SEVERO
IPC: G01D/
Filed: 2006-05-24
Abstract: Un sistema integral resistente a las intrusiones, provisto con un dispositivo óptico para se pueda leer remotamente el consumo medido de energía eléctrica en la red de distribución, y un dispositivo resistente a las intrusiones para operar el sistema que está comprendido por dispositivos para medir el consumo de energía eléctrica debidamente acoplado a la red de distribución local; el sistema hace posible leer el valor medido de una unidad de consumo remotamente a través de un ensamble óptico que hace posible expandir dicha lectura por medio de lentes, además evita que se derive el sistema y mantenga un ajuste sustancial del mismo aún cuando se requiera la conexión y/o reconexión al usuario del suministro de energía eléctrica.
Patent EC-SP088757-A (EC)
Title: Sistema seguro de transacciones electrónicas
Inventor: SANCHEZ JAVIER
IPC: G06Q20/00
Filed: 2008-09-22
Abstract: Los sistemas y los métodos para el procesamiento seguro de las transacciones electrónicas son divulgados. En acuerdo con una inclusión de ejemplo, un sistema y un método para el procesamiento seguro de las transacciones electrónicas comprende: recibir, por un terminal POS, la información para una tarjeta de transacciones financieras; recibir, por un terminal POS, la información para una transacción financiera; encriptar, por el terminal POS, la información financiera de la tarjeta y la información financiera de la transacción dentro de un primer mensaje encriptado; transmitir el primer mensaje encriptado a un chasis regional; encriptar, por el chasis regional, el primer mensaje encriptado dentro de un segundo mensaje encriptado; transmitir el segundo mensaje encriptado a un chasis central; desencriptar, por el chasis central, el segundo mensaje encriptado dentro de un mensaje desencriptado y; transmitir el mensaje desencriptado a un procesador del huésped para la autorización.
Patent EC-SP961679-A (EC)
Title: Cerradura de cilindro mecanicamente cambiable y llave con pasadores rotativos
Inventor: DOLEV MOSHE
IPC: E05B17/04
Filed: 1996-03-05
Abstract: El invento se refiere a uan cerradura de cilindro que tiene una combinación de llave modificable, incluyendo la cerradura de cilindro: una caja cilíndrica que define un calibre, un cilindro dispuesto en calibre para definir un bocacalle y por lo menos un pasador de cilindro dispuesto en el cilindro a lo largo de por lo menos un eje de pasador de cilindro y en comunicación con la bocacalle. Conatndo dicho pasador cilindrico de una cara terminal de ajuste de llave de tal manera que la rotación del pasador de cilindro alrededor del eje pasador de cilindro efectue un cambio en la combinación de llave de la cerradura de cilindro. También se decsriben y reivindican diversas llaves adecuadas para utilizarse con la cerradura.
Patent EC-SP972040-A (EC)
Title: Metodo para eregir paredes de concreto vaciado
Inventor: DE ZEN VITTORIO
IPC: E04B2/00
Filed: 1997-02-27
Abstract: Un método de erección de paredes estructurales reforzadas con concreto encampsulado comprendiendo el ensable de una variedad de componentes huecos termoplásticos entrelazados en por lo menos dos secciones de pared huecas entrelazadas dispuesta una en relación a la otra de tal manera que puedan ser unidas y soportar una plataforma colocada sobre ellas, con dichos componentes entrelazados de pared abierto en la parte superior de dicha pared y entrando en comunicación interna para el flujo de concreto entre si y con dicha plataforma facilitando acceso para el vaciado de concretodentro de algunos de dichos componentes entrelazados que forman la pared, luego vaciando concreto dentro de algunos de estos componentes entrelazados para que fluya entre dichos componentes.
Patent EC-SP982804-A (EC)
Title: Beta- lipotropina y usos de la misma
Inventor: HALE JOHN EDWARD
IPC: A61K38/33
Filed: 1998-12-21
Abstract: Una proteína sustancialmente pura que tiene una secuencia de aminoácidos seleccionada entre grupo constituido por la SEQ ID NO: 2, SEQ ID NO:5, SEQ ID NO:6 Y SEQ ID NO:7
Patent FI-20001156-A (FI)
Inventor: TAKALA ROOPE
IPC: G06F3/0488
Filed: 2000-05-15
Abstract: A device and method for implementing a key, in which a field applied to a layer comprising a material whose volume is responsive to the magnitude of field is altered at a specified position to create a key in said position; said field being one of the following: electric field, magnetic field, both of the above.
Patent FI-20115758-A (FI)
Inventor: MAUNSELL CARK
IPC: A23L29/20
Filed: 2011-07-18
Abstract: This invention relates to novel cereal products, especially natural cereal products of colloidal nature such as oats. The invention also relates production and uses of colloidal cereal products. Further the invention relates to cosmetic formulations containing cereal products.
Patent FI-20115861-A (FI)
Inventor: RIIVARI PETTERI
Filed: 2011-09-02
Abstract: A disc filter comprises a supply box (11) and a vat (8), whereby fibre pulp suspension to be supplied into the disc filter (1) is supplied to the vat (8) through the supply box (11). The disc filter (1) comprises at least one flow control element (30, 32, 44, 49) arranged to act on at least part of the flow (F) of the fibre pulp suspension to be supplied through the supply box (11) to the vat (8).  Also a method for supplying fibre pulp suspension into a disc filter (1).
Patent GB-1050760-A (GB)
IPC: D06M11/53
Abstract: 1,050,760. Polyacrylonitrile. FARBENFABRIKEN BAYER A.G. Nov. 9, 1965 [Nov. 9, 1964], No. 47459/65. Heading DIP. An article of homo-or co-polyacrylonitrile is rendered fire-proof and resistant to abrasion by treatment with a hot aqueous ammonium polysulphide solution. Acrylonitrile may have been copolymerised with methyl acrylate or styrene. The article is in the form of fibre, filament, foil, or knitted or woven material. The treatment may be at 80 or 180‹C under reflux. The treating solution may contain dimethyl formamide as swelling agent.
Patent GB-1085068-A (GB)
IPC: D01H5/26
Abstract: 1,085,068. Drafting. DEERING MILLIKEN RESEARCH CORPORATION. May 10, 1965 [May 8, 1964; Aug. 14, 1964; Feb. 3, 1965], No. 19730/65. Heading D1D. A cradle assembly for a pair of drafting rolls each having an apron thereabout comprises an element 26, 28 which has surfaces on either side of a nose 52 to guide and clean the apron running about its associated roll (14) (Figs. 1 and 2 not shown) and a surface 46 to clean said roll, wall members 32, 34 attached to the element 26, 28, and an element 30 which guides and cleans the apron (24) passing about the other roll (16), the element 30 having connecting means 85, 86 on each side to engage slots 88 in the walls 32, 34 and maintain the separation of the walls constant. As shown the element 26, 28 is preferably in two, push fit parts to facilitate the moulding of the cradle and its assembly. In other forms (Figs. 4, 5, 6 and 13 not shown) each wall member is a push fit on a central, hollow part. When mounted in a drafting assembly the cradle is positioned (see Fig. 2 not shown) so that the element 30 bears against the fibre contacting run of the belt only in the region of its nose portion; in addition the surface 56 contacting the lower belt is bevelled at 58; consequently fibre bundles of different diameter may be drafted. In Figs. 7, 8, 9 not shown, a cradle for use with longer staple fibres is shown in which a support bar (104) is provided for the front end of the cradle. The lower open element is in two parts (260, 280) joinable by co-operated pegs (106), and holes (108) and the upper apron member (300) has stub shafts (114) which are a snap fit into resilient openings (118, 120) in the wall members (320, 340). In this form the rear drafting rollers (10, 12) (Fig. 1) may be dispersed with. In Figs. 10, 11, 12 not shown, the cradle of Fig 2 is shown fitted to a conventional drawing head having twin top rollers carried on a pivotable weighting arm it being shown how the upper apron element 30 disengages from the lower element 26, 28 as the weighting arm is upwardly pivoted. The cradle is preferably of a readily mouldable plastics material e.g. nylon or acetal resin.
Patent GB-1231516-A (GB)
IPC: B65H54/80
Filed: 1969-02-21
Abstract: 1,231,516. Coiling wire or strip. DEMAG A.G. 21 Feb., 1969 [18 May, 1968], No. 9544/69 Heading B3E. [Also in Division B8] An apparatus for collecting, binding and removing rolled material in the form of wire or strip comprises a conveyer movable step-by-step past stations at which the collection, binding or removal of the rolled material takes place, the collection equipment comprising a winding mandrel 2 and a bipartite shell 4b concentric therewith and of the same length as the mandrel, the shell halves being adapted to be folded apart to release the finished coil of rolled material. The folding apart may be performed by hydraulic cylinders or by known electromagnetic means 5. The conveyer may be an endless chain conveyer, Fig. 1 and Fig. 4 (not shown), or a turntable, Figs. 2 and 3 (not shown).
Patent GB-1231730-A (GB)
IPC: B65G51/30
Filed: 1969-10-08
Abstract: 1,231,730. Pneumatic despatch apparatus. GORKOVSKY AVTOMOBILNY ZAVOD. 8 Oct., 1969, No. 49431/69. Heading B8A. A reception station for a pneumatically conveyed cartridge comprises a chamber 1 open at its receiving end and mounted for sliding movement against damping means 7, longitudinally of a pneumatic conveying tube 11, an aperture being provided in the longitudinal wall of the chamber for gravitational discharge of the cartridge. The chamber 1 is slidably mounted on guides 6 through sleeves 5 secured to the chamber, springs 7 encircling the guides between the sleeves and the ends of the guides to provide for cartridge impact damping. The interior of the chamber 1 is coated with rubber and has a rubber and felt cushion 2, 4 at its closed end 3.
Patent GB-1239730-A (GB)
IPC: F28C1/02
Filed: 1970-05-29
Abstract: 1,239,730. Air-cooled heat exchangers. G. SCHOLL. 29 May, 1970 [30 May, 1969], No. 25923/70. Addition to 1,159,134. Headings F4K and F4S. [Also in Division F1] In an air-cooled heat exchanger unit wherein air is induced to flow through the unit by an annular impeller comprising a plurality of equiangularly spaced blades 21 attached to a circular rail 20, a number of ropes 37 horizontally suspended at equidistant intervals between the rail 20 and a freely rotatable central hub 36 are provided for taking up any radial forces which arise when the rail 20 rotates. Each rope contains a turnbuckle 38 which permits, the rope tension to be suitably adjusted. The hub 36 is rotatable about a central supporting column. 32 which is maintained vertical by means of tensioned guy ropes 40 having turnbuckles 41. A ring shaped platform 18 carries a plurality of spaced. driving and/or support members for the circular rail. The drive members each comprise a rubber-tyred friction wheel 26 which bears against the underside of the rail and is carried on the end of a motor drive shaft mounted on a tiltable platform 23. As shown in Fig. 1, water to be cooled from an annular trough 7 is sprayed from radial pipes 8 to flow downwardly over slat-type grid elements 6 countercurrent to a flow of cooling air induced by the impeller, and is finally collected in a ring shaped basin 10. In an alternative embodiment (Fig. 4, not shown) the impeller blades are disposed vertically and heat exchange between the water and cooling air is indirect, the water being constrained to flow through heat exchange elements (49) extending between distribution and collection headers (50 and 51).
Patent GB-1258622-A (GB)
IPC: A47J31/40
Filed: 1969-01-23
Abstract: 1,258,622. Coffee infusion machine. OFFICINE CIMBALI GIUSEPPE S.p.A. Jan. 23, 1969 [Jan. 30, 1968], No.3835/69. Heading A4D. A coffee infusion machine comprises a slab 11, having a hole 20, reciprocatable between a first position, as shown in the Fig., wherein the hole 20 is coaxial with a vertical sleeve 19 in communication with a coffee grounds distributer 25 and also coaxial with a chamber 16 and a second position Fig. 3 (not shown) wherein the hole 20 is coaxial with pistons 31 and 32 containing part of the receptacle and hot water distribution systems respectively, the machine further includes a compacting piston 28 arranged above the vertical sleeve 19. In operation a load 43 of coffee grounds delivered to the hole 20 in its first position is compacted by the piston 28 which simultaneously ejects a spent plug 44 of coffee grounds into the chamber 16. The slab 11, and consequently the hole 20, is then moved to its second position whereat the pistons 31, 32 are moved into sealing engagement with the upper and lower surfaces of the slab around the hole 20 and hot water fed through the compacted load 43 of coffee grounds to produce a coffee infusion which is subsequently passed through a filter 133 in the piston 31. The sequence of operations is controlled by a programmer-timer device.
Patent GB-1264970-A (GB)
IPC: G01F1/66
Filed: 1969-10-15
Abstract: 1,264,970. Fluid flow measurement. WESTINGHOUSE ELECTRIC CORP. 15 Oct.,  1969 [28 Oct., 1968], No. 50661/69. Heading H4D. The volumetric flow rate, across a reference plane, of a fluid in a conduit is measured by a method of numerical integration of flow velocities over the plane, the method comprising deriving values each proportional to the product of the length l of a respective one k of a plurality of lines parallel to one another in the plane and terminating in the conduit boundaries, multiplied by the average flow velocity v in a direction perpendicular to both the plane and the respective line, applying to the said values respective weighting factors Wk associated with the distances X k  of the lines from a reference point in the plane according to a Gaussian, Chebycheff or Lobatto method of numerical quadrature, and summing the weighted values. In the Fig. 5 embodiment the difference #T between the upstream and downstream propagation times of an acoustic signal from a pair of transducers T1, T1<SP>1</SP> each periodically transmitting at an angle towards the other in pipe 16 is determined by gating the two received signals through transmit/receive control circuit 20 to a digital processor 46 for respectively starting and stopping a clock pulse counter. Path 1 of length l is a projection of the acoustic path on to a reference cross-sectional plane of pipe 16 and the count representing #T is proportional to l.v. Similar #T counts are derived under the control of timer 27 for the paths 2, 3 and 4 by means of further transducer pairs, further transmit/receive control circuits, and further counters or time-shared use of counters. The weighting factors Wk (examples are given for various numbers and spacings of the propagation paths), together with factors to allow for the speed of sound and the inclination of the propagation paths with respect to the flow direction, are applied to the #T counts before summation in processor 46 and the resultant may be time-averaged before display at 50. Total volume flow may be derived and displayed. The flow conduit may be an open channel (Fig. 7, not shown).
Patent GB-1288744-A (GB)
IPC: C22C38/10
Filed: 1968-10-10
Abstract: 1288744 Steel composition INTERNATIONAL NICKEL Ltd 10 Oct 1969 [10 Oct 1968 1 Jan 1969] 48086/68 and 97/69 Heading C7A A maraging steel comprises:- Co 7-9À5% Mo 3-5À5% Ni 23-26% Ti 0À15-0À7% Al 0-0À5% B 0-0À01% Be 0-0À5% C up to 0À03% Cu 0-2% Mn 0-1% Nb 0-3% Si 0-0À5% V 0-2% and Zr 0-0À1% the balance, apart from residual amounts of Co and Mg and the lowest possible amounts of H, O, P and S, being Fe; and has an M S temperature of 20‹ to -70‹ C. Up to 5%W may replace some or all of the Mo with a ratio of 2 parts W for each part of Mo replaced. The steel may be hot worked at 1250-1050‹C. with a suitable finishing temperature of 800-900‹ C; intermediate anneals in the cold working may be at 800-850‹ C.; the last cold working step should leave the steel in the martensitic state in which it can be aged at 400-500‹ C., but if the required transformation is not complete the steel may be cooled to at least -78‹C. and preferably to -196‹C.
Patent GB-1296793-A (GB)
IPC: C11D3/384
Filed: 1971-05-14
Abstract: 1296793 Detergents containing nucleoproteins GENERAL MILLS Inc 14 May 1971 15023/71 Heading C5D [Also in Division C3] A cleansing composition comprises one or more soaps, anionic, nonionic and amphoteric detergents and from 0À01 to 5À0% by wt. of solubilized nucleoprotein material from fish milt (fish sperm surrounded by connective tissue) or avian (e.g. chicken or turkey) blood. The fish milt is treated with a C 1 -C 5  alkanol and the insolubles recovered. The avian blood is centrifuged and the separated erythrocytes are haemolysed with ethanol or saponin and the insolubles recovered (see Division C3). Solubilization is by treatment in an aqueous medium with an organic salt including a surfactant or, when the nucleoprotein is from fish milt, with an inorganic salt. The nucleoproteins have a softening and protecting effect upon the hair and skin, increase lathering and thicken liquid cleansing preparations. Bar soaps and shampoos are illustrated.