baber/WOPTO huggingface dataset:
Patent NZ-598890-A (NZ)
Title: Inhibitors of iap
Inventor: COHEN FREDERICK
IPC: C07D209/02
Filed: 2008-04-29
Abstract: 598890 Disclosed herein are compounds of formula (I) U1-M-U2, wherein the variables are defined in the specification, the use of said compounds in the treatment of cancer, specifically by sensitising a cell to an apoptotic signal. Additionally, said compounds may be used for sequential or concomitant use with a pharmaceutical compound which induces an apoptotic signal, such as cytarabine, fludarabine, 5-fluoro-2'-deoxyuridine, 5 gemcitabine, methotrexate, bleomycin, cisplatin, cyclophosphamide, adriamycin (doxorubicin), mitoxantrone, camptothecin, topotecan, colcemid, colchicine, paclitaxel, vinblastine, vincristine, tamoxifen, finasteride, taxotere or mitomycin C or radiation.
Patent NZ-600767-A (NZ)
Title: Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
Inventor: AJANI MAURO
IPC: A61K31/573
Filed: 2008-07-24
Abstract: ABSTRACT - 600767 The disclosure relates to an enzymatic esterification process for obtaining 17(-propionate of cortexolone represented by formula (I), wherein R is CH3CH2, and its 9,11-dehydro derivatives starting from the corresponding 17(,21-diesters, wherein the process comprises an enzymatic alcoholysis reaction in presence of a lipase from Candida. Furthermore, the disclosure relates to crystalline forms of cortexolone 17(-propionate and 9,11-dehydro-cortexolone 17(-butanoate, for example by crystallizing said cortexolone-17(-propionate from a mixture of dichloromethane/n-hexane, or a mixture of acetone/n-hexane, or a mixture of ethanol/water, to get the crystalline form (III) characterised by a DRX spectrum defined in the specification.
Patent NZ-611427-A (NZ)
Title: Compositions and methods relating to proliferative diseases
Inventor: ROBERTSON GAVIN P
IPC: A61P35/00
Filed: 2011-12-06
Abstract: Provided are compositions comprising leelamine, a leelamine derivative, abietylamine, an abietylamine derivative or an abietic acid derivative. Leelamine is also known as [(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanamine, abietylamine is also known as { [(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthren-1-lyl]methyl} amine and abietic acid is also known as (1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid. Further provided are processes for the preparation of the compounds and the use of the compositions for the treatment of cancer.
Patent NZ-611711-A (NZ)
Title: Resin container
Inventor: KIRA GO
IPC: B65D1/02
Filed: 2011-12-14
Abstract: A resin container 1 comprising a neck section 2 to which a cap can be detachably attached, a shoulder section 3 formed continuously from the neck section 2, a body section 4 formed continuously from the shoulder section 3 and a bottom section 5 formed continuously from the body section 4 and located at a lowermost portion. The container 1 further comprises a cushioning section 10 placed towards the bottom section of the body section to be elastically deformable in a vertical direction and having a primary groove 20 that extends around the entire circumference of the body section 4. The primary groove 20 has a width that progressively increases radially outwards. The cushioning section 10 includes secondary grooves 21 extending around the entire circumference thereof and provided on each of an upper side and a lower side of the primary groove 20. The primary groove 20 has a depth greater than a depth of any one of the secondary grooves 21.
Patent NZ-617418-A (NZ)
Title: Antimicrobial/adjuvant compounds and methods
Inventor: WU FAN
IPC: C07D409/04
Filed: 2012-03-02
Abstract: Disclosed are antimicrobial and adjuvant compounds according to Formulae Ia and Ib where the substituents are as defined herein. Also disclosed are prodrugs and pharmaceutically acceptable salts thereof of the compounds and the use of the compounds as antimicrobials and in the manufacture of medicaments for the treatment of microbial infection.
Patent NZ-618135-A (NZ)
Title: Methods of synthesis and purification of heteroaryl compounds
Inventor: KOTHARE MOHIT ATUL
IPC: C07D487/04
Filed: 2010-10-22
Abstract: Disclosed is the use of compounds of formula (VII) such as sodium 2-(5-bromo-3-(ethylamino)pyrazin-2-ylamino)acetate as an intermediate in the preparation of compounds of formula (VIa) such as 7-bromo-1-ethyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, the method comprising cyclising a compound of formula (VII) in the presence of a base or an acid, wherein said cyclisation occurs under conditions suitable to provide a compound of formula (VIa), wherein: R2 is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl; R3 is H, or a substituted or unsubstituted alkyl; Hal is a halogen; and R is the alkali metal salt of the carboxylate; wherein an alkyl group, unless the context requires otherwise, is a saturated, partially saturated, or unsaturated straight chain or branched non-cyclic hydrocarbon having from 1 to 10 carbon atoms; and a cycloalkyl group, unless the context requires otherwise, is a saturated or partially saturated cyclic alkyl group of from 3 to 10 carbon atoms having a single cyclic ring or multiple condensed or bridged rings, and wherein the method may further comprise preparing a compound having formula (II) (such as 7-(5-fluoro-2-methyl-4-(1H-1,2,4-triazol-3-yl)phenyl)-1-((trans-4-methoxycyclohexyl)methyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one), comprising contacting a compound of formula (VIa) with R1-Y in a solvent, in the presence of a palladium catalyst, wherein Y is B(OR+)2 or Sn(R++)3; R1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylalkyl; and wherein the remaining substituents are as defined herein. Also disclosed is the compound sodium 2-(3,5-dibromopyrazin-2-ylamino)acetate which is a reactive intermediate useful in the preparation of compounds of formula (VII).
Patent NZ-628969-A (NZ)
Title: Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Inventor: AFROZE ROUSHAN
IPC: C07H5/04
Filed: 2013-02-14
Abstract: Disclosed are { 2,3-dihydroxy-4-[(2-aryl-pyrazolo[1,5-a]pyrimidin-7-yl)amino]cyclopentyl} methyl sulfamate derivatives as represented by the general formula (I) as the depicted single stereochemical isomer, or as an enantiomeric, racemic, or disatereomeric mixture of the depicted single stereochemical isomer; and pharmaceutically acceptable salts of any of the foregoing, wherein: W is -N(R*3)-; Y is pyrazolo[1,5-a]pyrimidin-7-yl substituted in positions 2 with the group Z; wherein Z is an optionally substituted aryl, an optionally substituted fused aryl: or an optionally substituted heteroaryl; and wherein the remaining substituents are as defined herein. Representative compounds include (2,3-dihydroxy-4-(2-(3-(trifluoromethylthio)phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate as either a racemate or single enantiomer (s.e.), ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-phenylpyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-2,3-dihydroxy-4-{ [2-(1-naphthyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino} cyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-4-(2-(3,3-dimethyl-2,3-dihydrobenzofuran-7-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-4-(5-chloro-2-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate and ((1R,2R,3S,4R)-4-(2-(dibenzo[b,d]furan-4-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate. Also disclosed is a pharmaceutical composition comprising, a compound as defined above and a pharmaceutically acceptable carrier, for use in treating lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma.
Patent NZ-702084-A (NZ)
Title: System and method for predicting the immunogenicity of a peptide
Inventor: PAZ PEDRO
IPC: G16B5/00
Filed: 2013-03-14
Abstract: A system, computer readable storage medium and method of predicting the immunogenicity of a peptide are provided. In certain cases the system includes: a) a model of a peptide, a model of a MHCII protein and a model of a T cell receptor; and b) an executable program for: (i) evaluating the strength of intermolecular interactions of a complex containing the peptide, the MHCII protein and the T cell receptor to provide a score that predicts the immunogenicity of the peptide; and (ii) outputting the score.
Patent NZ-702241-A (NZ)
Title: Composition comprising two antibodies engineered to have reduced and increased effector function
Inventor: KLEIN CHRISTIAN
IPC: C07K16/40
Filed: 2013-08-05
Abstract: The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector moiety, and (b) a second antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.
Patent NZ-718187-A (NZ)
Title: High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as pichia pastoris
Inventor: MCNEILL PATRICIA DIANNE
IPC: C12P21/08
Filed: 2012-05-08
Abstract: Discloses a method of producing a multi-subunit complex, wherein the multi-subunit complex does not comprise a full length antibody. The method comprises (a) providing a growth culture comprising Pichia pastoris cells comprising genes that provide for the expression of the subunits of said multi-subunit complex and growing said Pichia in said growth culture for 12-16 hours (“growth phase”); (b) adding ethanol to said culture after said growth phase in a single bolus addition (“bolus”) which bolus results in a concentration of ethanol in said culture of between 0.5% and 1.5% w/v; and (c) culturing said culture to produce said multi-subunit complex, wherein said culturing comprises adding a feed comprising a fermentable carbon source to said culture.
Patent NZ-733918-A (NZ)
Title: Method for the production of milk with a high content of native vitamin d
Inventor: GNANN TONY
IPC: A61N5/06
Filed: 2016-02-01
Abstract: Disclosed is a method for increasing the vitamin D3 levels found in milk from lactating animals such as cows, sheep or goats when housed in barns without access to natural sunlight. A luminaire and roofed enclosure are also disclosed. The method for the production of milk with a high native vitamin D3 content, comprises the irradiation of one or more lactating animals in a roofed enclosure having at least one luminaire comprising a lamp which emits UV-A radiation and UV-B radiation, and the milking of the animals. The lamp being a full-spectrum lamp and the UV-B radiation component in the emission spectrum of the lamp being between 0.2% to 5% of the irradiation intensity of the lamp, and the radiation component in the VIS range in the emission spectrum of the lamp being at least 70%, and the lactating animals are irradiated for 6 to 22 hours per day with the at least one luminaire.
Patent NZ-738078-A (NZ)
Title: Mct4 inhibitors for treating disease
Inventor: PARNELL KENNETH
IPC: A61K31/4155
Filed: 2016-06-13
Abstract: Disclosed herein are pyrazole derivatives useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases. Methods of inhibition MCT4 activity in a human or animal subject are also provided.
Patent NZ-740724-A (NZ)
Title: An overlay
Inventor: ROGER THOMAS MASCULL
IPC: A47C7/18
Filed: 2016-09-26
Abstract: A flexible, customisable backrest overlay for a seat, configured to substantially conform to a contoured surface to provide sufficient padding for comfort and to assist in preventing injuries associated with being seated for long periods. The overlay being configured to substantially confirm around a contoured surface of the backrest, and comprising a first layer having a front surface and a rear surface, wherein a plurality of channels are provided on the rear surface and extend in a first direction along the rear surface, wherein one or more first contouring members are located between adjacent channels and are attached to and project from the rear surface of the first layer and wherein one or more second contouring members are located between adjacent channels and are stacked on top of the one or more first contouring members so that the first and second level contouring members form stacks of contouring members between adjacent channels, and wherein perforation lines are provided between the stacked contouring members to allow each second contouring member to be torn or cut away from the first contouring member in the same stack to adjust the contours of the front surface to provide customized contoured cushioning to satisfy the postural alignment needs of the user.
Patent NZ-741214-A (NZ)
Title: Table game system
Inventor: SHIGETA YASUSHI
IPC: G07F17/32
Filed: 2013-07-08
Abstract: A table game system comprising shuffle playing cards composed of playing cards made up of a plurality of number of decks shuffled to have a unique arrangement order, a uniquely identifiable shuffled card ID being attached to the shuffled playing cards as an ID code; a card shoe apparatus that houses the shuffled playing cards such that the said shuffled playing cards can be manually dealt one by one onto a game table and reads from the card a code printed on the card concerning the rank thereof; a means capable of identifying the shuffled card ID; and a control unit that includes a memory for storing a plurality of association tables or a plurality of databases, each of which makes it possible to obtain the rank of each card based on the code of each card, wherein each association table or database is recorded in association with the shuffled card ID, and one of the plurality of association tables or databases is identified by identifying the shuffled card ID, and based on the association table or database identified, the card shoe apparatus reads the code when each card is drawn from the card housing unit and the rank of the card is identified based on that code, the system further comprises: a liquid crystal display unit which is provided on a side part of the card shoe apparatus that displays a mismatch, if the code read by the card shoe apparatus does not match a code that is defined in the association table or the database identified and, an output means which is provided on an upper part of the card shoe apparatus that output a result of a game.
Patent NZ-744083-A (NZ)
Title: Method of treating c3 glomerulopathy
Inventor: BEKKER PETRUS
IPC: A61K31/551
Filed: 2017-01-12
Abstract: Methods of treating a human suffering from or susceptible to C3 glomerulopathy comprising administering to the human an effective amount of a C5aR antagonist are provided.
Patent NZ-752644-A (NZ)
Title: Tunnel support system and method
Inventor: MULVOY JOHN M
IPC: E21D11/05
Filed: 2019-04-16
Abstract: A tunnel reinforcement system having a plurality of structural supports positioned at spaced intervals along the length of a tunnel. Each structural support has a plurality of structural segments connected in an end to end relationship. Each structural segment has a plurality of bars connected to a first end and a second end, in which the first end comprises a first butt plate having one or more apertures, and the second end comprises a second butt plate having one or more apertures. The one or more apertures of the first butt plate or the second butt plate of a structural segment are coaxially aligned with the one or more apertures of the first butt plate or the second butt plate of another structural segment in an end to end relationship. The first butt plate or the second butt plate of a structural segment is attachable to the first butt plate or the second butt plate of another structural segment in an end to end relationship. Each structural support defines a geometric supporting framework.
Patent PT-100741-A (PT)
Inventor: SIENKOWSKI MICHAEL L
IPC: C23C22/12
Filed: 1992-07-29
Abstract: Zinc phosphate coatings for metal surfaces and phosphating process. Concentrates containing (a) hydroxylamine sulfate and (b) zinc, nickel, manganese and phosphate ions are formulated into aqueous coating solutions for treating metal surfaces, including ferrous, zinc and aluminum surfaces.
Patent PT-103532-A (PT)
Title: Produção de espumas cerâmicas de cordierite por polimerização in situ
Inventor: SILVA ELISABETE RIBEIRO
IPC: B28B3/20
Filed: 2006-07-20
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM NOVO PROCESSO DE PRODUÇÃO DE ESPUMAS DE CORDIERITE DE ELEVADA POROSIDADE, SUPERIOR A 90%, POR UM MÉTODO DE POLIMERIZAÇÃO IN SITU . FORAM DESENVOLVIDAS NOVAS FORMULAÇÕES PARA A PRODUÇÃO DE ESPUMAS DE POLIURETANO COM CARGA CERÂMICA (PU/CERÂMICO) POR UM PROCESSO ENVOLVENDO A ADIÇÃO DE PARTÍCULAS CERÂMICAS A UM POLIOL FORMULADO E A UM ISOCIANATO, COM POSTERIOR REACÇÃO ENTRE ESTES DOIS COMPONENTES FORMULADOS. DEPENDENDO DAS FORMULAÇÕES, AS ESPUMAS PU/CERÂMICO OBTIDAS SÃO CARACTERIZADAS COMO RÍGIDAS OU SEMIRÍGÍDAS, DE CÉLULA ABERTA E/OU FECHADA, DE ALTO SUPORTE DE CARGA (ATÉ 50-60% EM MASSA) . APÓS QUEIMA E SINTERIZAÇÃO DAS ESPUMAS FORMULADAS, OBTEM-SE UMA VARIEDADE DE ESPUMAS DE CORDIERITE, NOMEADAMENTE AS DE CÉLULA ABERTA E POROSIDADE SUPERIOR A 90%. DEPENDENDO DA ESTRUTURA POROSA, AS ESPUMAS OBTIDAS SÃO APLICÁVEIS EM: FILTROS DE METAIS FUNDIDOS E GASES DE EXAUSTÃO, SUPORTES DE QUEIMADORES, DIFUSORES DE GASES, AREJAMENTO DE LÍQUIDOS E SUPORTES DE CATALISADORES.
Patent PT-105008-A (PT)
Title: Método para a redução da acidez e da acidez volátil em vinhos e outras bebidas, fermentadas ou não
Inventor: SANTOS PAULO JORGE FERREIRA CAMEIRA DOS
IPC: C12G1/02
Filed: 2010-03-15
Abstract: A PRESENTE INVENÇÃO PERTENCE AO DOMÍNIO TÉCNICO DAS TECNOLOGIAS DE PROCESSAMENTO DE PRODUTOS AGRO-ALIMENTARES, E ABORDA UM MÉTODO PARA REDUZIR A ACIDEZ VOLÁTIL EM VINHOS E OUTRAS BEBIDAS, NOMEADAMENTE ATRAVÉS DA UTILIZAÇÃO DE OSMOSE INVERSA (1) E ELECTRODIÁLISE (3). APLICANDO ESTE MÉTODO, POR EXEMPLO, A UM VINHO, MOSTO OU MOSTO PARCIALMENTE FERMENTADO (ΑLFA), QUE TENHA SIDO PROPOSITADAMENTE SUBMETIDO A UM PRÉ-TRATAMENTO DE ACETIFICAÇÃO BIOLÓGICA CONTROLADA, OU SUBMETIDO HIDRÓLISE ENZIMÁTICA CONTROLADA, OBTÉM-SE UMA BEBIDA (ΒETA), ISENTA DE AROMAS NEFASTOS, E PRESERVANDO TODAS AS CARACTERÍSTICAS ORGANOLÉTICAS ORIGINAIS. UM VINHO OU OUTRA BEBIDA PODE ADQUIRIR ACIDEZ VOLÁTIL DEVIDO AO CRESCIMENTO NATURAL OU PROPOSITADO DE BACTÉRIAS ACÉTICAS OU OUTROS MICRORGANISMOS, NOMEADAMENTE DO GÉNERO ACETOBACTER, FICANDO ENTÃO ALTERADO DO PONTO DE VISTA ORGANOLÉTICO. ISSO DEVE-SE AO SEU ENRIQUECIMENTO EM VÁRIOS TIPOS DE SUBSTÂNCIAS AROMÁTICAS, ALGUMAS DE BOAS CARACTERÍSTICAS (CARÁCTER BALSÂMICO, FLORAL) E OUTRAS DE CARACTERÍSTICAS NEFASTAS, POSSUINDO SABORES E AROMAS ACÉTICOS E PUNGENTES. PELA REMOÇÃO DOS SABORES E AROMAS ACÉTICOS E PUNGENTES, PELO MÉTODO DESCRITO NESTA INVENÇÃO, PERMANECEM OS BONS AROMAS LATENTES, QUE BENEFICIAM O VINHO SENSORIALMENTE. AS UTILIZAÇÕES PRINCIPAIS DESTE MÉTODO SÃO: REDUÇÃO DA ACIDEZ VOLÁTIL EM VINHOS, MOSTOS, CERVEJA, CIDRA, E OUTRAS BEBIDAS FERMENTADAS OU NÃO,
Patent PT-105496-A (PT)
Title: Sistema auto-adptativo para reabilitação de funções superiores no domicilio sob supervisão especializada
Inventor: CRUZ VITOR PEDRO TEDIM RAMOS
IPC: A61B5/00
Filed: 2011-01-20
Abstract: A PRESENTE INVENÇÃO ESTÁ RELACIONADA COM UM SISTEMA PARA IMPLEMENTAÇÃO DE PLANOS DE NEURORREABILITAÇÃO E EXECUÇÃO DE TAREFAS DE TREINO DE FUNÇÕES SUPERIORES, INCLUINDO MONITORIZAÇÃO POR PROFISSIONAIS ESPECIALIZADOS. A AROUITECTURA DESENVOLVIDA RECOLHE (1, 4) E ARMAZENA (3) INFORMAÇÃO SOBRE O DESEMPENHO DIÁRIO, ASSIDUIDADE, EFICÁCIA DE TREINO, ALERTAS DE FADIGA E OPINIÃO DOS FAMILIARES E EFECTUA RELATÓRIOS PERIÓDICOS (6) PARA APOIO Á TOMADA DE DECISÃO PELO PROFISSIONAL DE SAÚDE. O SISTEMA INCLUI FERRAMENTAS PARA AJUSTE AUTOMÁTICO (7) E PERSONALIZAÇÃO DOS PLANOS DE TREINO (2), MELHORANDO A ADESÃO DO UTILIZADOR, INTENSIDADE E EFICÁCIA. EXISTEM AINDA INSTRUMENTOS AUTOMATIZADOS DE APRENDIZAGEM A LONGO PRAZO (5, 8), QUE UTILIZAM OS REGISTOS DE UTILIZAÇÃO, CATEGORIZADOS POR FUNÇÃO SUPERIOR E EFICÁCIA OBTIDA, NA INCORPORAÇÃO DE MELHORIAS NOS PROGRAMAS DE TREINO FUTUROS. ESTA SOLUÇÃO TÉCNICA ELIMINA BARREIRAS FÍSICAS NO ACESSO AOS CUIDADOS DE REABILITAÇÃO, RENTABILIZA RECURSOS HUMANOS ESCASSOS E MELHORA A EFICÁCIA DOS PROGRAMAS DE TREINO.
Patent PT-108345-A (PT)
Title: Processos para produção de intermediários acilados de polissacáridos micobacterianos essenciais
Inventor: NUNO MIGUEL DA SILVA EMPADINHAS
IPC: C12P1/04
Filed: 2015-04-07
Abstract: A INVENÇÃO DESCREVE NOVOS PROCESSOS PARA A SÍNTESE DE INTERMEDIÁRIOS ACILADOS, ISTO É, OCTANOILDIGLUCOSILGLICERATO (ODGG), UM INTERMEDIÁRIO DA BIOSSÍNTESE DE LIPOPOLISSACÁRIDOS DE METILGLUCOSE (MGLP) DE MICOBACTÉRIAS, INCLUINDO A CAUSADORA DE TUBERCULOSE. O ODGG FOI IDENTIFICADO COMO UM IMPORTANTE PRECURSOR DESTE POLISSACÁRIDO VITAL E É UMA FERRAMENTA IMPORTANTE PARA A INVESTIGAÇÃO DE NOVAS ESTRATÉGIAS E ANTIBIÓTICOS PARA COMBATER INFEÇÕES CAUSADAS POR MICOBACTÉRIAS. A ENZIMA RESPONSÁVEL PELA SÍNTESE DE ODGG, CONSIDERADA ESSENCIAL PARA O CRESCIMENTO DA BACTÉRIA DA TUBERCULOSE, FOI CARACTERIZADA EM DETALHE E O SEU PRODUTO IDENTIFICADO. ESTE COMPOSTO RARO PRODUZIDO POR ESTA ENZIMA ESPECÍFICA E OS SEUS ANÁLOGOS PODEM A PARTIR DE AGORA SER PRODUZIDOS COM RECURSO A PROCEDIMENTOS DE SÍNTESE QUÍMICA CONCEBIDOS PARA ESCALA INDUSTRIAL. ESTA INVENÇÃO É CRUCIAL PARA APLICAÇÕES NA INVESTIGAÇÃO DE DOENÇAS INFECCIOSAS, EM ÁREAS DE BIOQUÍMICA E ENZIMOLOGIA, E TAMBÉM EM APLICAÇÕES BIOMÉDICAS E FARMACÊUTICAS DESIGNADAMENTE PARA DESCOBERTA DE NOVOS ANTIBIÓTICOS.
Patent PT-110493-A (PT)
Title: Desenvolvimento de um padrão interno para análises por pcr quantitativa de genes de resistência a antibióticos
Inventor: JAQUELINE ROCHA
IPC: C12R1/19
Filed: 2018-01-05
Abstract: A PRESENTE DIVULGAÇÃO REFERE-SE A ANÁLISES BASEADAS EM PCR QUANTITATIVA DE MICRORGANISMOS E DOS SEUS GENES EM SISTEMAS PARA A MONITORIZAÇÃO E CONTROLO DA QUALIDADE DA ÁGUA, INCLUINDO APÓS TRATAMENTO DE ÁGUAS RESIDUAIS. A INVENÇÃO FACILITARÁ A PRECISÃO E COMPARABILIDADE DE ANÁLISES MICROBIOLÓGICAS DA ÁGUA COM BASE EM PARÂMETROS GENÉTICOS, TORNANDO FIÁVEL A COMPARAÇÃO DE DADOS RECOLHIDOS AO LONGO DE DIFERENTES PERÍODOS DE TEMPO OU EM DIFERENTES LABORATÓRIOS. A INVENÇÃO SERÁ AINDA PARTICULARMENTE ÚTIL PARA O CONTROLO DE SISTEMAS DE ÁGUAS RESIDUAIS
Patent RU-94006069-A (RU)
Inventor: DUBROVSKIJ I A
IPC: A61B5/389
Filed: 1994-02-21
Abstract: FIELD: medicine. SUBSTANCE: method involves forming interrogation pulses and access signals built-in in time into them, sending interrogation pulses to muscle, storing muscle stress pulses according to access signals, recording variable component of stress detected in this way, forming stimulation signal and access interrupt signals from synchronization signals. Stimulation signal front is formed from access interrupt signal and stimulation signal section is formed from access lock signal section, stopping access signals formation during interrupt single action time. In case synchronization signal front coinciding in time with interrogation pulse, access interrupt signal is formed after the current interrogation pulse is over. In case interrupt signal section coinciding in time with interrogation pulse, interrupt signal section is formed after the current interrogation pulse is over. This way, muscle rheosignal distortions are excluded, recorded when stimulating the muscle. The device has high frequency filter, retrieval-storing circuit, adjusting stage and register. Beside that, the device has output interrogation pulses stage output stimulation pulses stage and control unit. The sequence of operations described above is provided with special design of the control unit in the present device. EFFECT: enhanced accuracy of diagnosis.