baber/WOPTO huggingface dataset:
Patent DK-2907506-T3 (DK)
Inventor: ARMENDARIZ BORUNDA JUAN
IPC: A61K31/4412
Filed: 2012-07-13
Granted: 2018-02-19
Abstract: The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-α and anti-TGF-β1 action for the treatment of hepatic fibrosis.
Patent DK-2926847-T3 (DK)
Inventor: FORSELL PETER
IPC: A61M25/00
Filed: 2006-10-26
Granted: 2022-07-04
Abstract: An infusion device for a drug delivery system comprises an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).
Patent DK-0443116-T3 (DK)
Inventor: FOISSNER HERBERT DIPL-ING FH
IPC: E05B47/06
Filed: 1990-11-28
Granted: 1994-09-05
Abstract: Arranged behind a closing plate (5) of a door frame is a blocking device having a slide (3) which can be brought out of a position of rest (RP) into a locking position (VP) or blocking position (SP) by an electric motor (1) via a drive mechanism (2). A stop (4) limits the blocking position (SP). The locking position (VP) is limited by the bolt (6) introduced into the closing plate (5). The slide (3) has an extension (3a) and the bolt (6) a formed-on portion (8), in the locking position (VP) the formed-on portion (8), together with the slide extension (3a), preventing a release. The drive mechanism (2) can be formed by a screw drive. The formed-on portion (8) can consist of a dowel pin. <IMAGE>
Patent DK-0404334-T3 (DK)
Inventor: BROBYN SUSAN ELIZABETH
IPC: A61P25/04
Filed: 1990-05-15
Granted: 1994-03-14
Abstract: Aerosol compositions for topical application, conferring a cooling effect on the body and suitable for use in the alleviation of pain, such as muscular or rheumatic pain, which compositions do not contain environmentally unacceptable chlorofluorocarbons but satisfy safety guidelines on flammability, and comprise an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from 10 to 40<o>C and an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from -45 to -10<o>C, in a ratio of from 3 to 7 parts by weight of the higher boiling component (serving primarily as a coolant) per part by weight of the lower boiling component (serving primarily as a propellant).
Patent DK-0533661-T3 (DK)
Inventor: OSBAKK GEORG
IPC: B65D1/02
Filed: 1990-01-26
Granted: 1996-03-04
Abstract: PCT No. PCT/NO90/00019 Sec. 371 Date Aug. 22, 1991 Sec. 102(e) Date Aug. 22, 1991 PCT Filed Jan. 26, 1990 PCT Pub. No. WO90/08698 PCT Pub. Date Aug. 9, 1990.A compressible body comprising a container and a flexible annular wall member, and the container, in turn, includes a cylindrical side wall and a prestressed locking member. The side wall of the container forms an upper edge and defines a cylindrical space having a given circumference, and the locking member of the container is mounted on the upper edge of the side wall and is inherently biased radially inwardly toward a position inward of that given circumference. The wall member of the bottle is mounted inside the container of the bottle, and that wall member has extended and compressed positions. In the extended position, the wall member extends upward from the container; and in the compressed position, the wall member is at least substantially contained within the container and the upper portion of the wall member is below the locking member of the container. Moreover, when the wall member is compressed into its compressed position, the locking member moves radially inwardly, due to is inherent resiliency, to a locking position in which the locking member extends directly over the upper portion of the wall member and locks that wall member inside the container.
Patent DK-0469094-T3 (DK)
Inventor: ANDERBERG NILS-ERIC
IPC: G08G5/06
Filed: 1990-04-19
Granted: 1994-11-07
Abstract: In a system for information/guidance and mechanised parking of aircraft at a carefully predetermined stopping point in an airport, a display unit which is positioned in front of the stopping point, and in or closely adjacent thereto a microwave antenna which emits waves towards the aircraft, which waves are reflected back to the antenna and received thereby. By measuring the time difference between the emitted and the received waves the aircraft position can be analyzed with great accuracy by a computer and be indicated on the display unit.
Patent DK-0428753-T3 (DK)
Inventor: FUNABIKI MASAKI
IPC: B01J23/63
Filed: 1990-06-08
Granted: 1995-07-03
Abstract: Exhaust gas purificn. catalyst consists of a monolithic support coated with a catalytic layer which contains activated alumina; at least one Pt gp. element (such as rhodium); cerium oxide; a copptd. oxide of zirconium stabilised by cerium; and opt. a zirconium cpd. The copptd. oxide of Zr stabilised by Ce pref. contains 99-75% by wt. (esp. 95-85%) Zr oxide and 1-25% (esp. 5-15%) Ce oxide. The catalyst is produced by coating the support with a slurry contg. the above components, and firing.
Patent DK-0470405-T3 (DK)
Inventor: GELLERT JOBST ULRICH
IPC: B29C45/17
Filed: 1991-07-16
Granted: 1995-06-26
Abstract: An insulative and resilient spacer member to be mounted between a heated manifold (18) and a cooled clamp plate (36) in an injection molding system. The spacer member has a plurality of V-shaped concentric rings. It has a uniform cross section with a number of web portions extending diagonally between alternate forward and rearward ridge portions. The outer surfaces of the alternate ridge portions are aligned to provide forward (92) and rearward (96) sides of the spacer member which extend parallel a predetermined distance apart. Some of the outer surfaces (90,94) have an inwardly extending insulative circular groove. The spacer member is formed of steel to have a predetermined combination of strength, resilience and reduced thermal conductivity. <IMAGE>
Patent DK-0474087-T3 (DK)
Inventor: DRAKE CHARLES ALFRED
IPC: C07C2/24
Filed: 1991-08-26
Granted: 1995-10-09
Abstract: Catalyst supports, catalyst systems, methods for the preparation thereof, in dimerization processes therewith are provided. Catalyst supports are prepared from alkali metal carbonate, at least one low surface area silica-alumina, and a liquid. Catalyst systems comprised of at least one elemental alkali metal deposited on the catalyst support. Optionally, the catalyst system further comprises of at least one promoter.
Patent DK-0484966-T3 (DK)
Inventor: YAMANAKA MOTOSUKE
IPC: C07D501/26
Filed: 1991-11-08
Granted: 2001-05-07
Abstract: A compound represented by the following formula (1a): a process for the preparation thereof, an antibacterial composition comprising the same and the use thereof for the preparation of a medicament and for the synthesis of related cephem compounds.
Patent DK-0548098-T3 (DK)
Inventor: MEIXNER HANS-WERNER
IPC: A22C17/00
Filed: 1991-08-20
Granted: 1994-11-28
Abstract: A knife consisting of a blade with a tang which is mounted in a handle. A guide, preferably made of plastic, in which the tang can be quickly moved to and fro by an oil-pressurized piston against the pressure of at least one spring, is provided in the handle. The piston runs in a cylinder provided in the handle of the knife. The oil line is connected with a central station located some distance away.
Patent DK-0550463-T3 (DK)
Inventor: HART GERALD LESLIE
IPC: C11D1/94
Filed: 1991-08-28
Granted: 1996-11-04
Abstract: This invention relates to a method of stabilizing liposomes contained in aqueous compositions against lysis by anionic surfactants otherwise known to disrupt and lyse such liposomes by using certain surfactants as stabilizing agents and to the stabilized compositions obtained thereby as well as to a method of making detergent compositions containing such stabilized liposomes and anionic surfactants as well as to the compositions themselves. The compositions can be used as shower gels and shampoos. The liposomes are preferably vesicles derived from natural phospholipids or from synthetic nonionic amphiphilic compounds which are sometimes referred to as "niosomes" and may contain water soluble humectants or vitamins. From about 0.1% to 40%, and more preferably, from 2% to 10%, by weight of at least one surfactant such as fatty alkyl sulfosuccinates (fatty alkyl group contains from 8 to 22 carbons atoms), fatty acylamino polyglycol ether sulfates (fatty acyl group contains from 8 to 22 carbon atoms), fatty alkyl amine oxides (fatty alkyl group contains from 7 to 26 carbon atoms), fatty alkyl phosphate esters (fatty alkyl group contains from 8 to 22 carbon atoms), and N-acyl amino acid salts or salts of N-acyl derivatives of hydrolyzed proteins of up to about 2,500 daltons in weight average molecular weight (acyl portion is derived from a carboxylic acid having from 8 to 22 carbon atoms) is added to an aqueous composition containing from about 0.1% to 50%, and more preferably from 5% to 30%, by volume of liposomes to produce a stabilized liposome suspension. Such stabilized liposome suspensions can then be included in a detergent formulation containing from about 0.1 to 35%, and more preferably from 5% to 15%, by weight of at least one anionic surfactant which is known to lyse liposomes such as sodium lauryl sulfate or sodium laureth-2 sulfate.
Patent DK-0535548-T3 (DK)
Inventor: SAITO YASUSHI
IPC: C07D495/04
Filed: 1992-09-24
Granted: 2002-05-13
Abstract: An inhibitor of atherosclerotic intimal thickening, which contains an effective amount of a compound of the formula (I): <CHEM> wherein ring X is phenyl, substituted phenyl or 5- or 6-membered heterocyclic aryl; each of R<1> and R<2> which are independent of each other, is hydrogen, C<5> PI 3/4  alkyl, C<7> PI 1/2  cycloalkyl, C<5> PI <7> alkoxy, n-butoxy, i-butoxy, sec-butoxy, tert-butoxy, R<2>0R<2><1>N- (wherein each of R<2>0 and R<2><1> which are independent of each other, is hydrogen or C<5> PI <7> alkyl), trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-tert-butylsilyloxy, hydroxymethyl or -O(CH<6>)POR<2><2> (wherein R<2><2> is hydrogen or C<5> PI <7> alkyl, and P is 1, 2, or 3); or R<1> and R<2> together form -CH=CH-CH=CH- or methylenedioxy, when they are at the o-position to each other; R<3> is hydrogen, C<5> PI 3/4  alkyl, C<6> PI 1/4  alkenyl, C<7> PI 1/2  cycloalkyl, C psi  PI 1/2  cycloalkenyl or <CHEM> (wherein R7 is hydrogen, C<5> PI 3/4  alkyl, C<5> PI 3/4  alkoxy, C<5> PI <7> alkylthio, chloro, bromo, fluoro, chloromethyl, trichloromethyl, trifluoromethyl, trifluoromethoxy, trichloromethoxy, difluoromethoxy, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-tert-butylsilyloxy or hydroxymethyl); or C<5> PI <7> alkyl substituted by one <CHEM> (wherein R7 is as defined above) and zero, one or two C<5> PI <7> alkyl; Y is -CH<6>-, -CH<6>CH<6>-, -CH=CH-, -CH<6>-CH=CH-, -CH=CH-CH<6>-, -C(CH<7>)=CH- or -CH=C(CH<7>)-;     Z is -Q-CH<6>-W-CH<6>-CO<6>R<1><2>, <CHEM>  (wherein Q is -C(O)-, -C(OR<1><3>)<6>- or -CH(OH)-,     W is -C(O), -C(OR<1><3>)<6>- or -C(R<1><1>)(OH)-,     R<1><1> is hydrogen or C<5> PI <7> alkyl, R<1><2> is hydrogen, R<1>4 (wherein R<1>4 is alkyl of a chemically or physiologically hydrolyzable alkyl ester moiety, NHR<2><3>R<2>4R<2>5 (wherein each of R<2><3>, R<2>4 and R<2>5 is hydrogen or C<5> PI <8> alkyl), sodium, potassium or 1/2 calcium), each R<1><3> is independently primary or secondary C<5> PI 1/4 alkyl, or two R<1><3> together form -(CH<6>)<6>- or -(CH<6>)<7>-, and each of R<1>5 and R<1>6 which are independent of each other, is hydrogen atom or C<5> PI <7> alkyl, or R<1>5 and R<1>6 together form -(CH<6>)<6>- or -(CH<6>)<7>-.
Patent DK-0663013-T3 (DK)
Inventor: EPAND RICHARD M
IPC: A61K47/48
Filed: 1992-08-28
Granted: 2005-08-01
Abstract: A method for facilitating the transfer of nucleic acids into cells comprising preparing a mixed lipid dispersion of a cationic lipid with a co-lipid in a suitable carrier solvent. The lipid has a structure which includes a lipophilic group derived from cholesterol, a linker bond, a spacer arm including from about 1 to about 20 carbon atoms in a branched or unbranched linear alkyl chain, and a cationic amino group selected from the group consisting of primary, secondary, tertiary and quaternary amino groups. The method further comprises adding the nucleic acids to the dispersion to form a complex. The cells are then treated with the complex. There is also disclosed a novel cationic amphiphile useful for this purpose.
Patent DK-0658344-T3 (DK)
Inventor: KAGAYAMA AKIRA
IPC: A61K9/127
Filed: 1992-10-26
Granted: 2000-04-17
Abstract: A liposome preparation containing, incorporated in liposome, an immunosuppressive tricyclic compound or a pharmaceutically acceptable salt thereof. Since the tricyclic compound is incorporated in liposome stably and quantitatively, a pharmaceutical preparation with an excellent persistence of drug efficacy can be provided in a wide variety of preparation forms. <IMAGE>
Patent DK-0595610-T3 (DK)
Inventor: KARANEWSKY DONALD S
IPC: A61P9/00
Filed: 1993-10-27
Granted: 1997-08-25
Abstract: Compounds of the formula <CHEM>  wherein A is <CHEM>  are useful as ACE and NEP inhibitors and those wherein A is <CHEM> are useful as ACE inhibitors. Methods of preparation and intermediates are also disclosed.
Patent DK-0640101-T3 (DK)
Inventor: JOHN B HARLEY
IPC: C07K19/00
Filed: 1993-04-13
Granted: 2000-05-15
Abstract: A number of octapeptides were generated from the sequences encoding the 60 kDa Ro/SSA peptide, the La/SSB autoantigen, the 70 kD nuclear ribonucleoprotein (nRNP), and the Sm B/B' polypeptide, which represent linear epitopes for autoantibodies present in the sera of SLE and SS patients. These peptides are useful in solid phase assays for patients characterized by the presence of these autoantibodies, and can be used to categorize patients as to the likelihood of developing certain conditions associated with SLE. The peptides are also potentially useful in treatment of these patients using immobilized peptide to remove autoantibody and to block binding of the autoantibodies with patient molecules reactive with the autoantibodies.
Patent DK-0720538-T3 (DK)
Inventor: HAHN KARL
IPC: B60L3/10
Filed: 1994-09-03
Granted: 1997-03-24
Abstract: The invention relates to a process for improved control of the driving and/or braking force on the wheels of a vehicle, especially the driving wheels of total-adhesion railway traction vehicles, in order to achieve optimal adhesion, where the wheels are run within a narrow range of oscillation about the maximum of the adhesion-slip characteristic curve of the wheel-rail contact, either by continually increasing and then reducing the driving/braking force or by increasing and reducing the acceleration for a set rotational speed. To improve wheel-rail contact through concertedly higher wheel-slip by adapting processes with which each wheelset can be run at the limit of adhesion with minimum slip without using the measured value of speed over ground, the invention proposes that in each case only some of the vehicle's wheels/wheelsets are regulated to produce optimal maximum adhesion, while the others are subject to a desired wheel-slip control, wherein the measured wheel speed/rotational speed on the wheels/wheelsets at optimal adhesion serve as reference speed to which the wheel speed/rotational speed of the other wheels/wheelsets is ajusted after a desired slip rate has been added. Thus a continual, for example cyclical, alternation of wheelsets can be done with increased and little slip.
Patent DK-0699507-T3 (DK)
Inventor: SORENSEN JOSEPH A
IPC: B25B5/10
Filed: 1995-01-27
Granted: 1999-06-14
Abstract: A pipe clamp includes a clamp body (16) which supports a screw (38). A jaw is mounted at one end of the screw and an actuator (58) is used to advance the screw with respect to the clamp body (16) in order to clamp or spread a workpiece (W) with respect to a workpiece-engaging element. The clamp body (16) is movable along the length of the pipe (12), and the screw (38) is inclined with respect to the pipe to increase clearance for the actuator (58). <MATH>
Patent DK-0694643-T3 (DK)
Inventor: FOUREZON ANDRE
IPC: D04H13/00
Filed: 1995-07-17
Granted: 1999-02-22
Abstract: The textile fabric for use in a composite material, such as of a resin base such as polyester and others for use in moulds using pressure or injection or vacuum, has a layer (4) of synthetic fibres at least at one surface. The other layers (1-3) are stitched to the main layer (4) so that the layers (1-4) are all bonded together. Pref. The fibres of the fibre layer (4) are synthetic, significantly thinner than the other fibres in the composite fabric structure. The fibre layer (4) is a material with a weight of 50-150 g/m<2>, of polyester, with fibres of 1-7 dtex. <IMAGE>
Patent DK-0740766-T3 (DK)
Inventor: VON WEDEL KARL
IPC: F27D15/02
Filed: 1995-11-15
Granted: 2000-07-31
Abstract: PCT No. PCT/EP95/04495 Sec. 371 Date Jun. 11, 1996 Sec. 102(e) Date Jun. 11, 1996 PCT Filed Nov. 15, 1995 PCT Pub. No. WO96/16306 PCT Pub. Date May 30, 1996This invention concerns a grate plate arrangement for step grates wherein a plurality of grate plates (2) can be laid side-by-side on to a grate carrier (2) and can each be fixed to the grate carrier by means of a respective clamping device (11) which engages the grate plate and the grate carrier. In this arrangement, the clamping device (11) includes at least one clamping element (12) whose end (14), which is towards the grate plate, engages through an opening (15) in a front end wall (3) of the grate plate (2). The clamping device has clamping means (16) which are actuable from the front end wall side. The other clamping element end, which is towards the grate carrier, is provided with anchoring means (13) for force-transmitting connection to the grate carrier. This arrangement makes it possible for the grate plates to be mounted or dismantled from the top side of the grate, so that the mounting operation can be performed in a more rational fashion and in a better manner from the point of view of maintenance, and industrial health and safety standards.
Patent DK-0817648-T3 (DK)
Inventor: KIM KYUNG JIN
IPC: A61K38/18
Filed: 1996-03-28
Granted: 2005-04-04
Abstract: The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, as well as other diseases and disorders characterized by undesirable or excessive neovascularization.
Patent DK-0863752-T3 (DK)
Inventor: LINDLEY IVAN JAMES DALTON
IPC: A61P31/04
Filed: 1996-07-05
Granted: 2003-04-22
Abstract: PCT No. PCT/EP96/02970 Sec. 371 Date Jan. 6, 1998 Sec. 102(e) Date Jan. 6, 1998 PCT Filed Jul. 5, 1996 PCT Pub. No. WO97/02026 PCT Pub. Date Jan. 23, 1997Use of compounds of formula (I), wherein R has various significances, in free base form or in pharmaceutically acceptable salt form, as agents against H. pylori infection and associated diseases.
Patent DK-0786431-T3 (DK)
Inventor: BIEDENBACH WALTER
IPC: B66C23/78
Filed: 1997-01-15
Granted: 2000-10-09
Abstract: The crane has a stand (2) on its own chassis, on which an extendable boom (3) can turn. The stand, without the ballast boom, is on another vehicle (4), independent of the road vehicle and of smaller dimensions. The vehicle has a ballast arrangement. On the free end there are support beams carrying a leg. The small vehicle can be mounted on and released from the road vehicle, and when removed from it, can travel and manoeuvre independently.
Patent DK-0932569-T3 (DK)
Inventor: BERNARD FREDERIC
IPC: B65G51/03
Filed: 1997-10-17
Granted: 2002-04-29
Abstract: A device for conveying objects having a protuberance at their neck including a blowing chamber for blowing an air flux for driving the objects and a support rail cooperating with the objects at the protuberance. The chamber includes a body and a plate removably attached thereto. The support rail is fixed to the plate. There are at least two frame members on either side of the rail along the blowing chamber.
Patent DK-1017675-T3 (DK)
Inventor: HAUSHEER FREDERICK H
IPC: C07D487/00
Filed: 1998-02-11
Granted: 2006-10-16
Abstract: This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or diluents.
Patent DK-0974151-T3 (DK)
Inventor: THAMM CHRISTIAN ALFONS
IPC: H01H1/58
Filed: 1998-04-09
Granted: 2001-09-24
Abstract: A switch device for switching an electrical connection between two connection parts is disclosed. Conventional switch devices comprise a contact lever having a switch contact, the flow of current taking place by way of the contact lever when the switch device is closed. To achieve a rapid switching process, a low mass inertia of the contact lever is required. However, this generally leads to a lower current capacity. By arranging the lever-side switch contact on a separate electrical connection device, it becomes possible to separate the function of current conduction from the function of contact guidance. Since the contact lever therefore no longer performs any current-conducting function, it may be optimized in mechanical respects exclusively.
Patent DK-0989910-T3 (DK)
Inventor: BLOECKER HELMUT
IPC: G01N1/34
Filed: 1998-06-19
Granted: 2003-06-16
Abstract: In a vacuum chamber, which has at least two vacuum regions, substances, especially fluids, are transported in a directed manner from one region into the other region by the application of a suitable vacuum. As a result, it is possibly by the use of filter supports or receiver supports to transport a fluid automatically through corresponding filter supports during a plasmid preparation. The vacuum chamber is charged by means of a gripping robot that operates automatically and is switched by a suitable valve control means. By incorporating the vacuum chamber with its gripping robot and the control means into a pipetting robot system, automatic plasmid preparation, for example in accordance with the Qiagen protocol, is possible.