baber/WOPTO huggingface dataset:
Patent NO-319331-B1 (NO)
Inventor: BORDIGNON CLAUDIO
IPC: A61K39/00
Filed: 1996-11-18
Abstract: A method for the production of antigen-specific cytotoxic T-cells (CTLs) by incubating a T cell-containing cell preparation with said antigen and isolating said antigen-specific CTLs, characterized by i) activating proliferation of CTLs in the cell preparation by incubation with the antigen; ii) selectively transferring a vector into the proliferating CTLs, said vector containing a marker gene by means of which marked and non-marked cells can be separated; and iii) separating the transfected antigen-specific CTLs on the basis of said marker gene, is useful for immunomodulation.
Patent NO-313402-B1 (NO)
Inventor: JANS EUGENE MARIE JOZEF
IPC: A23K10/38
Filed: 1996-11-19
Abstract: PCT No. PCT/EP95/01801 Sec. 371 Date Oct. 31, 1996 Sec. 102(e) Date Oct. 31, 1996 PCT Filed May 12, 1995 PCT Pub. No. WO95/31963 PCT Pub. Date Nov. 30, 1995The present invention relates to compositions comprising flubendazole of formula (I), which are palatable to companion animals, especially dogs.anthelmintic compositions for the treatment of helminthiasis.
Patent NO-308032-B1 (NO)
Inventor: BREAULT GLORIA ANNE
IPC: C07D277/20
Filed: 1997-01-24
Abstract: PCT No. PCT/GB95/01728 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/03380 PCT Pub. Date Feb. 8, 1996The present invention relates to compounds of formula (I),    <IMAGE>  (I)  wherein A is an optionally substituted phenyl naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring carbon atoms or a bicyclic ring system, provided that the -CH(R3)N(R2)B-R1 and -OCH(R4-)-D linking groups arm positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the -OCHR4- linking group (and therefore in the 3-position relative to the -CHR3NR2- linking group) is not substituted; B is an optionally substituted ring system; D is an optionally substituted ring system; R1 is a variety of group as defined in the description; R2 is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenylC1-3alkyl or 5- or 6-membered heteroarylC1-3alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydrogen or C1-4alkyl; and N-oxides of NR2 where chemically possible; and S-oxides of sulphur containing rings were chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof. Process for their preparation, intermediates in theirpreparation, their use as therapeutic agents and pharmaceutical compositions containing them.
Patent NO-316354-B1 (NO)
Inventor: MEZEI MICHAEL
IPC: A61P25/28
Filed: 1997-04-23
Abstract: PCT No. PCT/HU95/00052 Sec. 371 Date Aug. 5, 1997 Sec. 102(e) Date Aug. 5, 1997 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/12472 PCT Pub. Date May 2, 1996This invention provides liposomic composition, containing as active ingredient (-)-N- alpha -dimethyl-N-(2-propynylphenylethylamine) (selegilin) and/or salt thereof. This composition contains: 0.1-40% by weight of selegilin and/or a salt thereof, 2 to 40% by weight of lipids, preferably phospholipids, 0 to 10% by weight of cholesterol, 0 to 20% by weight of an alcohol, 0 to 25% by weight of a glycol, 0 to 3% by weight of an antioxidant, 0 to 3% by weight of a preserving agent, 0 to 2% by weight of a viscosity influencing agent, 0 to 50% by weight of cyclodextrin or a cyclodextrin derivative and 30 to 90% by weight of water. This invention relates to pharmaceutical composition, containing the liposomic composition described and if desired, usual filling and diluting agents and other auxiliaries, preferably in oral, parenteral or transdermal form. This invention provides the process for the preparation of liposomic compositions containing selegilin and/or salt thereof. Accordingly liposomic composition of this invention may be administered for the treatment of Alzheimeir's disease, Parkinson's disease, depression, stroke, motion sickness or myelitis.
Patent NO-323008-B1 (NO)
Inventor: WOODWARD GARY
IPC: C11D3/00
Filed: 1998-02-25
Abstract: The reaction of compounds of the formula: X2O3P CHY CZ2 where Y and each Z are each H, PO3X2, SO3X or CO2X (e.g. vinyl phosphonic acid or vinylidene diphosphonic acid) with hypophosphorous acid in the presence of free radicals provides novel compounds X2O3PCHYCZ2PO2XH which react with monomers such as vinyl sulphonate, vinyl phosphonate, vinylidene diphosphonate and acrylic acid to form telomers useful for scale inhibition, especially barium scale in oil wells. The polymers show better absorption to rock than PVSA and better thermal stability than random copolymers containing equivalent phosphorus.
Patent NO-316192-B1 (NO)
Title: Apparat til setting av et forlengingsrör i en brönns fôringsrör
Inventor: GUDMESTAD TARALD
IPC: E21B41/00
Filed: 1998-06-09
Abstract: Et apparat till setting av et forlengingsrør (1) i et foringsrør (2) omfatter en forlengingsrørshenger (LH) og et setteverktøy (100). Setteverktøyet (100) er forsynt med et ventilsete (5), som når det i bruk blir sperret, tillater fluidtrykk å utvikle seg til setting av forlengingsrørshengeren (LH) i brønnforingsrøret (2). Etter at forlengingsrørshengeren (LH) er blitt satt, vil påføringen av ytterligere trykk forskyve ventilsetet (5) for å frigjøre (eller i det minste muliggjøre frigjøring av) setteverktøyet (100) og til late fluidgjennomstrømning gjennom setteverktøyet (100).
Patent NO-334026-B1 (NO)
Title: Seismisk datasystem samt fremgangsmåte for kontinuerlig innsamling av slike data
Inventor: MORGAN PAUL MCDONALD
IPC: G01V1/00
Filed: 1999-06-17
Abstract: Et system for seismisk datainnsamling har blitt oppfunnet, som i bestemte henseende har ett eller flere multiple distribuerte dataiinsamlings-subsystemer som er uavhengige av energikilde- kontrolleren og/eller navigasjonssystem- operasjon. Således krever ikke de distribuerte innsamlingssystemene noe komplisert og tungvindt grensesnitt til energikilde-kontrolleren eller navigasjonssystemene. Det seismiske datainnsamlingssystemet støtter en kontinuerlig datastrøm som bufres i et sentralisert datalager for korttidslagring inntil det behøves i ikke-sanntids- prosesser. En seismisk datainnsamlings- metode eller -fremgangsmåte har blitt oppfunnet som erstatter konvensjonelt nær knyttet samvirke mellom seismiske innsamlingssystemer og energikildekontrolleren og navigasjonssystemet ved å benytte GPS- tidsmerker på både dataene så vell som sykliske hendelser i energikilde- konrolleren og/eller navigasjonssystemeene for å sikre en nøyaktig assosiering av seismiske data med sykliske hendelser. Ved kontinuerlig innsamling av data uten avbrudd i den innsamlede datastrøm kan assosiering med energikilde- eller navigasjons-hendelser oppnås ved et senere tidspunkt og ikke i sanntidsoperasjon i innsamlings-subsystemet.
Patent AT-503176-B1 (AT)
IPC: B60F1/04
Filed: 2006-01-26
Granted: 2008-01-15
Abstract: The invention relates to a travelling machine for working on roadways or surfaces along roadways, in particular railway tracks and railway track superstructures. The machine comprises a set of transport wheels for travelling in the direction of the roadway, in particular on the railway tracks, a vehicle frame upon which is arranged the vehicle load, such as driver's cab, loading platform, working tools and the like, and a set of working wheels on the vehicle frame, in addition to the transport wheels. The travelling machine is characterised in that at least one of the working wheels, preferably all working wheels, can be deployed laterally and vertically adjusted, and the working wheels, which can rotate about approximately horizontal wheel axles, can in addition swivel about vertical axes.
Patent AT-504636-B1 (AT)
Title: Spreading device for mobile grit container in muck- and compost spreaders utilized in agricultural field, has ejector comprising ejector housing rotatably supported around vertical axis about displacement angle based on output direction
IPC: A01C3/06
Filed: 2007-03-20
Granted: 2008-07-15
Abstract: The device (1) has a discharger (7) comprising a rotatably supported discharging rotor (9) provided with a horizontal discharging rotor axis (11) that points in a direction of a discharging section (6) containing grit. The discharger has a discharge opening (16) arranged at a peripheral surface of a discharge housing (10). The opening and an ejector (8) are arranged at a peak point of an outer peripheral surface of the housing. The ejector has an ejector housing rotatably supported around a vertical axis (25) about a displacement angle (27) of 160 degrees based on an output direction (26). An independent claim is also included for a muck- or compost spreader comprising a spreading device.
Patent AT-514379-B1 (AT)
Title: Spannbetonschwelle
Inventor: RINNHOFER GERHARD DR
IPC: E01B3/34
Filed: 2013-06-12
Granted: 2015-04-15
Abstract: Bei einer Betonschwelle (1) für einen Gleiskörper, mit einem Betonkörper (2), wobei die Schlagschutzeinrichtung (3) - in Betriebslage gesehen - im Bereich einer Oberseite (4) des Betonkörpers (2) angeordnet ist, wird vorgeschlagen, dass die Schlagschutzeinrichtung (3) innerhalb des Betonkörpers (2) zwischen der Oberseite (4) des Betonkörpers (2) und Spannelementen (8) der Betonschwelle (1) angeordnet ist.
Patent AT-509790-B1 (AT)
Title: Verfahren zum datenaustausch zwischen einem telekommunikationsendgerät und einer datenbank eines dienstanbieters
Inventor: HAINZL JOHANNES ING
IPC: G06F17/30
Filed: 2010-04-19
Granted: 2013-01-15
Abstract: Ein Verfahren und ein Telekommunikationssystem zum Datenaustausch zwischen zumindest einem einem Benutzer zugeordneten Telekommunikationsendgerät (2) und einer Datenbank (3) eines Dienstanbieters in einem Telekommunikationssystem (1) mit zumindest einem öffentlichen verbindungsorientierten Telekommunikationsnetz (4) zur Sprachübertragung und zumindest einem Datenübertragungsnetz (5) zur paketorientierten Datenübertragung, wobei dem Dienstanbieter mehrere Telekommunikationsanschlüsse (6, 7, 8, 9) mit je einer originären Teilnehmerrufnummer (6a, 7a, 8a, 9a) zugeordnet sind, die Telekommunikationsanschlüsse (6, 7, 8, 9) über zumindest eine Schnittstelle (10) mit dem Datenübertragungsnetz (5) verbunden sind und die Telefonanschlüsse (6, 7, 8, 9) kaskadenartig miteinander verschaltet sind, wobei nach erfolgtem Sprachverbindungsaufbau zwischen einem der dem Dienstanbieter zugeordneten Telekommunikationsanschlüsse (6, 7, 8, 9) ein Programm (14) für eine Sprachmenüführung zur Abfrage der Datenbank (3) oder zur Änderung von in der Datenbank (3) hinterlegten Daten aufgerufen wird, welches auf einem Server (12) des Datenübertragungsnetzes (5) abläuft, wobei die von dem Programm (14) generierten Sprachdaten gemäß dem Voice over IP Protokoll über das Datenübertragungsnetz (5) an die Schnittstelle (10) übertragen und über die offene Telekommunikationsverbindung zwischen dem Telekommunikationsanschluss (6, 7, 8, 9) des Dienstanbieters und dem Telekommunikationsendgerät (2) des Benutzers (13) weitergeleitet werden.
Patent AT-505131-B1 (AT)
Title: Befestigungsring
Inventor: BIALLAS INGO
IPC: F16D1/06
Filed: 2008-05-05
Granted: 2013-01-15
Abstract: Die Erfindung betrifft einen Befestigungsadapter 1, insbesondere zur Verwendung bei einer Welle-Nabe-Verbindung in der Robotik, bestehend aus einer Flanschscheibe 2 zum axialen Positionieren eines auf einer Welle angeordneten, um seine Längsachse drehbaren Teils. Um einen möglichst klein bauenden Befestigungsadapter 1 zu schaffen, wird erfindungsgemäß vorgesehen, dass die Flanschscheibe 2 einteilig und in Radial- und Axialrichtung schlitzlos ausgebildet und zumindest ein erster Umfangsabschnitt als Stützkörper und zumindest ein zweiter Umfangsabschnitt als Klemmkörper ausgebildet ist. Hierdurch wird eine äußerst flache Welle-Nabe-Verbindung geschaffen, die beispielweise in absolut messenden mikrotechnisch aufgebauten und hochauflösenden GMR-Hohlwellengebern eingesetzt werden kann.
Patent AT-502387-B1 (AT)
Title: Bale pressing method for cellulose flocks, comprises weighing cellulose supplied to press
Inventor: WRITZL WALTER ING
Filed: 2005-05-06
Granted: 2007-03-15
Abstract: The cellulose is weighed before being supplied to the press (8, 9, 34) and the supply of cellulose is interrupted once a predetermined weight has been reached. A method for compacting cellulose flocks in order to form preferably prism-shaped bales in a press comprises weighing the cellulose and then supplying it to the press. The supply of cellulose is interrupted once a predetermined weight has been reached. An independent claim is also included for the process apparatus, comprising a cellulose feed (1) containing a weighing device (5).
Patent AT-500085-B1 (AT)
IPC: B29D29/06
Filed: 2003-05-28
Granted: 2007-01-15
Abstract: The invention relates to an endless, belt-shaped tension element ( 1 ) for a conveyor system with at least one joining point ( 2 ) comprising an elastomer, in particular a cross-linked and/or thermoplastic elastomer, at least one reinforcing layer and optionally at least one tension support ( 3 ), two ends of the at least one reinforcing layer being disposed at the at least one joining point ( 2 ). An insert piece ( 6 ) is disposed between the two ends at the joining point ( 2 ), subtending an angle alpha with the tension element longitudinal extension, and the ends of the at least one reinforcing layer overlap with the insert piece ( 6 ).
Patent BR-0004778-B1 (BR)
Inventor: BARBOTIN FANNY
IPC: C08L23/08
Filed: 2000-10-11
Abstract: Polymerization catalytic system comprises an organometallic complex (I) and a co-catalyst comprising alkyl magnesium, alkyl lithium, alkyl aluminum and/or Grignard reagents. Polymerization catalytic system comprises an organometallic complex of formula (I) and a co-catalyst comprising alkyl magnesium, alkyl lithium, alkyl aluminum and/or Grignard reagents. Ln : lanthanide metal having an atomic number of 57-71, preferably neodymium; X : halo such as Cl, F, Br or I; Cp : cyclopentadienyl or fluorenyl groups (both linked to Ln, optionally substituted and linked between them by a bridge T); T : MR2; M : column IVA element of Mendeleev's periodic table, preferably Si; and R : 1-20C alkyl. Provided that when the Cp is cyclopentadienyl substituted by alkyl silyl then it exhibits the formula (C5H3)(Si(CH3)3), when Cp is non-substituted fluorenyl group then it exhibits the formula C13H8. An independent claim is included for the preparation of the catalytic system comprising preparing an organometallic complex by reacting alkyl lithium with hydrogenated ligand molecule of formula (HCp) to obtain a lithium salt, reacting the salt with a lanthanide trihalide anhydride of formula (LnX3), in a complexing solvent, evaporating the complexing solvent then extracting the obtained product in a non-complexing solvent, and optionally crystallizing the extracted product to obtain the organometallic complex, which is completely free of the complexing solvent, and adding the co-catalyst to the organometallic complex. [Image].
Patent BR-0206293-B1 (BR)
Inventor: EMERY DARYLL A
IPC: A61P37/04
Filed: 2002-01-03
Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
Patent BR-PI0210866-B1 (BR)
Title: compostos beta-amino tetra-hidroimidazo (1,2-a) pirazina e tetra-hidrotriazolo (4,3-a) pirazina, usos dos mesmos e composição farmacêutica
Inventor: WEBER ANN E
IPC: A61P25/00
Filed: 2002-07-05
Abstract: "composto, composição farmacêutica, e, métodos para inibição da atividade da enzima dipeptidil-peptidase iv em um mamífero, para tratamento, controle, ou prevenção de diabetes, de hiperglicemia, de obesidade, de resistência à insulina, de um ou mais distúrbios, de aterosclerose, de uma ou mais condições, para tratamento ou controle de deficiência de hormônio de crescimento e de infecção de hiv, para modulação da resposta imune e para redução da mobilidade de esperma". a presente invenção refere-se aos compostos que são inibidores da enzima dipeptidil-peptidase-iv ("inibidores de dp-iv") e que são úteis no tratamento ou na prevenção de doenças nas quais a enzima dipeptidil-peptidase-iv está envolvida, tais como diabetes e particularmente diabetes tipo 2. a invenção também se refere às composições farmacêuticas compreendendo estes compostos e ao uso destes compostos e destas composições na prevenção ou no tratamento de tais doenças nas quais a enzima dipeptidil-peptidase-iv está envolvida.
Patent BR-PI0317584-B1 (BR)
Inventor: RUTESH D PARIKH
IPC: H02G15/113
Filed: 2003-12-11
Abstract: A terminal for use with telecommunication cables has a splice closure and a terminal closure joined to the splice closure. The splice closure encloses opened areas of the cable, while the terminal closure encloses a connection device for establishing connection between telecommunication lines in the splice closure and a drop line. In various embodiments, a frame is mounted within the splice closure for retaining non-spliced lines of the telecommunication cable away from spliced lines; a storage member is located within the terminal closure for retaining excess lengths of the drop line; a drop line strain relief bracket is mounted within the terminal closure; and a memory device is incorporated into the terminal for storing information about the terminal.
Patent BR-9805947-B1 (BR)
Inventor: HOEHN-SARIC RUDOLPH CHRISTOPHER
IPC: G06Q50/00
Filed: 1998-03-10
Abstract: The system includes a central station (1), a registration station (2) and a remote testing station (3). The central station (1) includes storage device (13) for storing data, which include test question data and verified biometric data, and a data processor (10), operably connected to the storage device (13), for comparing test taker biometric data with stored verified biometric data. The remote test station (3) includes a data processor (30), a data storage device (31), operably connected to the data processor (30), for storing input data, a biometric measurement device (34) for inputting test taker biometric data to the data processor (30), a display (32) for displaying test question data, an input (33) for inputting test response data to the data processor (30), a recorder (35) for recording proctoring data of a testing event, and a communication link for communicating with the central station (1).
Patent CH-704484-B1 (CH)
Inventor: SUTTER ERICH
IPC: B65H75/14
Filed: 2011-02-03
Abstract: Ein Kabelträger als Transportmittel und Montagehilfe für ein aufwickelbares Kabel weist eine Spuleneinheit (2) auf, um deren Spulenumfangsbereich (3) ein Kabel (1) aufwickelbar ist. Von einem ersten und einem zweiten gegenüberliegenden Ende der Spuleneinheit (2) ragt jeweils eine Umfangswand (4a, 4b) zumindest teilweise über den Spulenumfangsbereich (3) ab, und ein vom Spulenumfangsbereich (3) und den Umfangswänden (4a, 4b) ausgebildetes Kabelfach (5) weist einen um den Spulenumfangsbereich (3) umlaufenden Umfangsschlitz (6) zum Abwickeln des Kabels aus dem Kabelfach auf.
Patent CH-707796-B1 (CH)
Title: Montre comprenant un réhaut portant des moyens de connexion électrique.
Inventor: EMMANUEL FLEURY
IPC: G04G21/08
Filed: 2013-03-28
Abstract: L’invention concerne une montre comprenant une carrure (2) qui délimite avec une glace (4) une boîte de montre (6), la glace (4) comprenant une face supérieure (8) orientée du côté d’un utilisateur, et une face inférieure (10) orientée du côté de la boîte de montre (6), un dispositif électronique étant agencé sur la face inférieure (10) de la glace (4), une carte de circuit imprimé (18) étant disposée dans la boîte de montre (6), sous le dispositif électronique et à distance de celui-ci. La montre comprend un réhaut (26) disposé entre la glace (4) et la carte de circuit imprimé (18) portant des moyens de connexion électrique pour assurer la connexion électrique entre le dispositif électronique et la carte de circuit imprimé (18).
Patent DE-2602907-B1 (DE)
Title: Stable contrast agent emulsions for lymphography - contg. iodinated fatty acid glycerides and an emulsifier
Inventor: ROTH STEPHAN DR MED
IPC: A61K49/04
Filed: 1976-01-27
Abstract: New aq. emulsions of iodinated glycerine fatty acid esters consists of 50-60 wt.% of an iodinated glycerine fatty acid ester or mixt. of such esters with an alkyl chain length of is not 10 C-atoms; 2-10 wt.% of a polyoxyethylenesorbitan fatty acid ester as emulsifier; and 2-40 wt.% water. Used in diluted form, the emulsions are suitable for use as X-ray contrast agents, particularly in lymphography and hepatosplenography. The emulsions are stable and can be sterilized without problems. When diluted, they can be administered without adverse effects, and are well absorbed, so that after-effects are few. A formulation given in an example is as follows: Basic emulsion produced from 4g polyoxyethylene-sorbitan monostearate and 4g redistilled water; 60g iodinated poppy oil (40 wt.% iodine- "Lipiodol" RTM) added to base emulsion with 100g redistilled water.
Patent DE-2936022-B1 (DE)
Inventor: MARMANN HORST
IPC: B23K7/10
Filed: 1979-09-06
Abstract: 1. A tube member (1) for oxygen lances, which contains the oxygen valve (5) with the operating mechanism, the reverse current stop valve (6), the slag return stop valve (7) and the clamping holder (8) for the lance tube (9), characterized in that its portion receiving the valves (5, 6, 7) is made integral with the lever guard (3).
Patent WO-0226233-B1 (WO)
Title: Solution pour perfusion de ciprofloxacine stable au stockage et a teneur reduite en acide
Inventor: SOMMERMEYER KLAUS
IPC: A61K31/496
Filed: 2001-09-27
Abstract: L'invention concerne des solutions stables au stockage, pour perfusion d'acide 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pipérazinyl)-quinoline-3-carboxylique (ciprofloxacine), qui s'obtiennent par mélange de 0,015 à 0,5 g de principe actif pour 100 ml de solution aqueuse avec de l'acide sulfurique ou de l'hydrogénosulfate de sodium dans des proportions inférieures ou égales à 0,96 mole par mole de principe actif, suffisamment élevées pour provoquer la dissolution du principe actif et pour stabiliser la solution. L'invention concerne également des procédés servant à produire ces solutions pour perfusion de ciprofloxacine ainsi que l'utilisation de ces dernières. Ces solutions pour perfusion permettent de réduire la teneur en acide, présentent, pour une même teneur en acide, une meilleure stabilité au stockage que les autres solutions connus et permettent la tolérance d'une proportion plus importante de composants secondaires dans le principe actif que les solutions pour perfusion de ciprofloxacine utilisées jusqu'à présent.
Patent ES-2096511-B1 (ES)
Title: Mejoras en el objeto de la patente principal n-p9201705 por: "ascensor hidrostatico".
Inventor: AREVALO SANS JOSE ANTONIO
IPC: B66B9/04
Filed: 1993-04-15
Granted: 1997-11-01
Abstract: EL PRESENTE CERTIFICADO DE ADICION COMPRENDE UN FLOTADOR QUE SE DESPLAZA POR EL INTERIOR DE LA RAMA VERTICAL DE UN DEPOSITO SUPERIOR VERTICAL SUSTANCIALMENTE EN L Y QUE ES EXTRAIBLE AL EXTERIOR POR UNA PUERTA DE ACCESO PRACTICADA EN LA RAMA EN PROLONGACION RADIAL, Y UNA CABINA PARA VIAJEROS DE CONFIGURACION EN ANILLO CIRCULAR TUBULAR QUE RODEA EL DEPOSITO SUPERIOR Y SOBRE EL QUE SE DESPLAZA EXTERIORMENTE, CUYOS FLOTADOR Y CABINA ESTAN CONECTADOS POR MEDIOS DE TRANSMISION.