Patent CA-3015309-A1 (CA)
Title: Carbapenem compounds
Inventor: BALASUBRAMANIAN GOPALAN
IPC: A61K31/407
Filed: 2017-03-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau                                (10) International Publication Number (43) International Publication Date                   WO 2017/158616 A8 21 September 2017 (21.09.2017) WIPO I PCT (51) International Patent Classification:       1862 Lamberts Mill Road Scotch Plains, NJ 07076 (US). CO7D 487/04 (2006.01)    A61K 31/407 (2006.01)    SINGH, Sheo; 19 Firethorn Drive Edison, NJ 08820 (US). CO7D 519/00 (2006.01)    A61P 31/00 (2006.01)    DONG, Shuzhi; c/o Merck Sharp & Dohme Corp., 2000 Galloping Hill Road Kenilworth, NJ 07033 (US). WANG, (21) International Application Number: Hongwu; c/o Merck Sharp & Dohme Corp., 2000 Galloping Hill Road Kenilworth, NJ 07033 (US). YOUNG, Kather-(22) International Filing Date:    ine; c/o Merck Sharp & Dohme Corp., 2000 Galloping Hill 15 March 2017 (15.03.2017)    Road Kenilworth, NJ 07033 (US). (25) Filing Language:                                                               English (74) Agent: AHUJA, Sudhir, D. et al.; D.P. Ahuja & Co., G-135F Spencer Plaza, Phase 3, 769 Anna Salai, Chennai (26) Publication Language:                English 600002, Tamil Nadu (IN). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 201641009127       16 March 2016 (16.03.2016)    IN kind of national protection available): AE, AG, AL, AM, (71) Applicants: ORCHID PHARMA LTD. [IN/IN]; Or-    AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, chid Towers, 313, Valluvar Kottam High Road, Nungam-    CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, bakkam, Chennai-600034, Tamihiadu (IN). MERCK    DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, SHARP & DOHME CORP. [US/US]; 126 E. Lincoln Av-    HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, enue, Rahway, New Jersey 07065 (US).            KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (72) Inventors: BALASUBRAMANIAN, Gopalan; Or--                                           PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, chid Phanna Ltd, 476/14, Old Mahabalipuram Road,    SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Sozhanganallur, Chennai-600119, Tamihiadu (IN). PAUL-TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. SATYASEELA, Maneesh; 410, Hara Vijaya Heights, BWSSB, Pipeline road, Uttarahalli Manevarthekaval, Ba- (84) Designated States (unless otherwise indicated, for every nashankari 6th Stage, Bengaluru 560062, Karnataka (IN).    kind of regional protection available): ARIPO (BW, GH, SRINIVASAN, Chidambaram, Venkateswaran; Or-     GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, chid Phanna Ltd, 476/14, Old Mahabalipuram Road,    UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Sozhanganallur, Chennai-600119, Tamihiadu (IN). IY-    TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, ER, Sridhar, Ramanathan; 504, Parsn Aahana, Mam-    EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, bakkam Road, Vengaivasal, Sithalapakkam Post, Chennai    MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 600126 (IN). PERIASAMY, Hariharan; Orchid Phanna    TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Ltd, 476/14, Old Mahabalipuram Road, Sozhanganallur,    KM, ML, MR, NE, SN, TD, TG). Chennai-600119, Tamilnadu (IN). PARAMESWARAN, Venkatesan; Orchid Phanna Ltd, 476/14, Old Mahabalipu- Published: ram Road, Sozhanganallur, Chennai-600119, Tamilnadu ¨ with international search report (Art. 21(3)) (IN). THIRUNAVUKKARASU, Bharani; Orchid Phar-(48) Date of publication of this corrected version: ma Ltd, 476/14, Old Mahabalipuram Road, Sozhanganal-07 June 2018 (07.06.2018) Chennai-600119, Tamilnadu (IN). GUNTURU, Prato-= hakar, Rao; Gowrigudem (VIII), Sidharam (PO), Kham- (15) Information about Correction: mam (Dt), Telangana - 507303 (IN). DESHKUMAR,    see Notice of 07 June 2018 (07.06.2018) Manjula, Devi; Orchid Phanna Ltd, 476/14, Old Maha-= balipuram Road, Sozhanganallur, Chennai-600119, Tamil-nadu (IN). JAKKALA, Venkateshwarlu; Orchid Phar-_ ma Ltd, 476/14, Old Mahabalipuram Road, Sozhanganal-GC                                    Chennai-600119, Tamilnadu (IN). NARGUND, Ravi, P.; c/o Merck Sharp & Dohme Corp., 2000 Galloping Hill Road Kenilworth, NJ 07033 (US). MILLER, Michael;    GC   ___________________________________________________________________________ (54) Title: CARBAPENEM COMPOUNDS IN (57) Abstract: This invention relates to carbapenem compounds, their stereoisomers, pharmaceutically acceptable salts or N-oxides thereof, which may be useful for the treatment of bacterial infections, particularly drug-resistant bacterial infections, as well as the el processes for the preparation of compounds, the pharmaceutical compositions of these compounds and their use in the treatment of cbacterial infection.