baber/WOPTO huggingface dataset:
Patent CA-2117543-A1 (CA)
Title: Dipeptidylquinazolones as anti-cancer agents
Inventor: BISSET GRAHAM M F
IPC: C07D239/95
Filed: 1993-03-16
Abstract: Quinazolines of formula (I) wherein R1 is hydrogen or amino, or R1 is alkyl, alkoxy or alkylthio each of up to 6 carbon atoms; or R1 is aryl or aryloxy each of up to 10 carbon atoms; or R1 is halogeno, hydroxy or mercapto; or R1 is alkyl of up to 3 carbon atoms which bears one or more substituents selected from halogeno, hydroxy and alkanoylamino each of up to 6 carbon atoms; or R1 is alkoxy of up to 3 carbon atoms which bears one or more substituents selected from hydroxy and alkoxy of up to 6 carbon atoms; wherein R2 is hydrogen or alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, alkylthioalkyl, halogenoalkyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkanoylalkyl, carboxyalkyl, carbamoylalkyl or alkanoyl each of up to 6 carbon atoms; wherein Ar is phenylene or heterocyclene which is unsubstituted or which bears one or more substituents selected from halogeno, cyano, nitro, hydroxy, amino and carbamoyl and alkyl, alkoxy, halogenoalkyl, alkanoylamino, alkylthio and alkoxycarbonyl each of up to 6 carbon atoms; R3 is the residue of a dipeptide in which the first, N-terminal amino acid residue thereof attached to the carbonyl group of COR3 is an amino acid residue (a) in which A is a carbon-carbon single bond or an alkylene group of up to 5 carbon atoms and V and V' are each separately hydrogen, or alkyl, alkenyl or alkynyl each of up to 6 carbon atoms; and the second amino acid residue is of an .alpha.-amino acid or a pharmaceutically-acceptable salt, ester or amide thereof are of therapeutic value, particularly in the treatment of cancer.
Patent CA-2118309-A1 (CA)
Inventor: TEDDER THOMAS F
IPC: C12R1/91
Filed: 1993-04-14
Abstract: Lymphocyte activation antigen HB15, and the human cDNA and gene sequences encoding HB15, are disclosed. HB15 is not expressed at detectable levels by circulating leukocytes but has a unique pattern of expression among tissues. HB15 is uniquely expressed by Langerhan's cells within the skin and other subpopulations of dendritic cells. Also disclosed are antibodies reactive with HB15 and methods of using anti-HB15 antibodies, or other antagonists to HB15 function, to treat an immunological disorder, disease or syndrome.
Patent CA-2118434-A1 (CA)
Title: Progressive jackpot gaming with random prize generation
Inventor: HUARD MARCEL
IPC: A63F3/08
Filed: 1994-10-19
Abstract: In a progressive jackpot game provides an auxiliary opportunity for players at a casino to win a prize from the progressive jackpot by participating with a relatively small contribution to the progressive jackpot each time they play a round in the principal casino game. To increase the element of random chance or luck in winning a prize from the progressive jackpot game, a method and apparatus is provided for randomly choosing a winning card or combination of cards, or randomly selecting a person or group of persons eligible to win upon possession of the card or combination of cards. The amount of the prize can also be randomly selected either as a fixed amount or percentage of the progressive jackpot.
Patent CA-2119942-A1 (CA)
Inventor: SHAO CHIA-MU
IPC: A63B49/02
Filed: 1994-03-25
Abstract: A retrieval device for shuttlecocks comprises includes an adhering device disposed on a racket and an engaging part disposed on a shuttlecock, whereby the shuttlecock is picked up by engagement of the adhering device and the engaging part.
Patent CA-2122987-A1 (CA)
Title: Dye transfer inhibiting compositions
Inventor: BUSCH ALFRED
IPC: D06L4/40
Filed: 1992-10-28
Abstract: Dye transfer inhibiting compositions are disclosed, comprising an enzyme exhibiting peroxidase activity, a hydrogen peroxide or a hydrogen peroxide precursor or an enzymatic system capable of generating hydrogen peroxide, an additional oxidizable substrate, and a cellulase, characterized in that the cellulase provides at least 10 % removal of immobilized radioactive labelled carboxymethyl cellulose according to C14CMC method at 25 x 10-6 % by weight of the laundry test solution.  According to the present invention, a preferred cellulase consists essentially of a homogeneous endoglucanase component which is immunoreactive with a monoclonal antibody raised against a partially purified = 43 kD cellulase derived from Humicola insolens:DM1800.
Patent CA-2125095-A1 (CA)
Inventor: PATRICK PAUL H
IPC: A01K45/00
Filed: 1994-06-03
Abstract: The invention relates to an automated system for monitoring wildlife auditory data and recording same for subsequent analysis and identification. The system comprises one or more microphones coupled to a recording apparatus for recording wildlife vocalizations in digital format.   The resultant  recorded data  is preprocessed,  segmented,  and analyzed by means  of  a neural  network to  identify the respective species.  The system minimizes the need for human intervention and subjective interpretation of the recorded sounds.
Patent CA-2125142-A1 (CA)
Title: Highly water soluble bis-naphthalimides useful as anticancer agents
Inventor: SUN JUNG-HUI
IPC: C07D221/14
Filed: 1992-12-11
Abstract: This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis(methylimino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[de]i_ soquinoline-1,3(2H)-dione], 2-[2-[N-methyl-N-[2-[[2-(5-nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-yl)et_ hyl]amino]ethyl]amino]ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione, 2,2'-[1,2-ethanediylbis(imino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[de]isoquin_ oline-1,3(2H)-dione], pharmaceutical compositions containing them, and methods of using them to treat solid tumor carcinomas in mammals.
Patent CA-2126487-A1 (CA)
Inventor: OKABE KEIICHIRO
IPC: A61N1/30
Filed: 1994-06-22
Abstract: To avoid a reduction of the conductivity in iontophoresis due to the electrical decomposition and the changes in chemical properties of the electrodes themselves, covering by an electrical insulator, and to prevent a drop in the transport rate due to ions freed from the electrode.      Provision is made of an electrode structure provided integrally with a reversible electrode and an auxiliary electrode for regeneration of the same and a regeneration current conducting means for conducting a current fox regeneration of the reversible electrode when the therapeutic current is off, or the invention is comprised of a reversible electrode and an ion exchange membrane difficult for ions freed from that electrode to penetrate.
Patent CA-2128453-A1 (CA)
Inventor: MAUGHAN GARTH B
IPC: F16C11/06
Filed: 1994-07-20
Abstract: BALL AND SOCKET JOINT ASSEMBLY                     ABSTRACT OF THE DISCLOSURE             A bearing set for a ball socket joint comprises an outer bearing and an inner bearing with a head of a ball stud engaging a spherical inner seat face of each of the bearings. A compression pre-load is applied when the inner bearing is inserted into a cavity of the outer bearing, a cylindrical outer wedge surface of the inner bearing having a greater diameter than a corresponding diameter of an inner skirt defining the cavity of the outer bearing. The bearing set is subjected to additional compression pre-load when the bearing set and ball stud are inserted into a socket and the socket is closed. The two-piece bearing set promotes easy joint assembly, results in a joint that is extremely tight with no axial or radial play, but allows necessary ball stud rotation and oscillation, and compensates for wear by a self-adjusting feature whereby some of the compression pre-load is released as wear takes place.
Patent CA-2129487-A1 (CA)
Inventor: MARTIN GUY
IPC: B08B15/02
Filed: 1994-08-04
Abstract: Enclosure (1) for repairing a portion of a vehicle (6), including a plurality of modular panels (2) forming a ceiling, wall, floor, characterised in that the panels (2) are joined together so as to form a volume encompassing, on the one hand, all or part of the vehicle (6) and, on the other hand, all the means required for repairing the said vehicle, the said volume being equipped on one of its sides with at least one opening (3) for introducing the said vehicle (6), the said opening being provided over all or part of its periphery with a sealing member (4) making it possible to use the said enclosure (1) in a configuration which is reduced in terms of volume and in terms of energy. <IMAGE>
Patent CA-2130719-A1 (CA)
Title: Organopolysiloxane mixture for the preparation of adhesive-repellent organopolysiloxane films
Inventor: DE MONTIGNY ARMAND
IPC: C08K3/00
Filed: 1994-08-23
Abstract: An  organopolysiloxane  mixture  for  the  preparation  of adhesive-repellent organopolysiloxane films A B S T R A C T     An organopolysiloxane composition that can be crosslinked by addition, comprising a)   a  branched  organopolysiloxane  having  unsaturated hydrocarbon groups, -    wherein at least 90% of the organo groups are methyl groups, -    the molecular weight of which is on average from 9,000 to 60,000, -    wherein the ratio of the number of diorganosiloxy units (D-units) to the number of branch points is on average between 15 and 40, and -    wherein at  least  one  triorganosiloxy unit  (M-unit) and at maximum half of all the M-units are free of unsaturated radicals,  the remaining M-units each have only one unsaturated radical and the content of unsaturated radicals is from 0.2 to 1 mmol/g and b)   a linear methylhydrogenpolysiloxane, -    wherein the number of siloxy units per mole is greater than the ratio of the number of D-units to the number of branch points of component a), -    wherein at least half of the difunctional siloxy units  (D-units)  have  hydrogen  atoms  directly bonded to silicon, and -    wherein the components a) and b) are present in a relative proportion such that the ratio of the number  of  SiH  groups  of  component  b)  to  the number  of  unsaturated  hydrocarbon  atoms  of component a) is between 1.5 and 3.5, and c)   a catalyzing quantity of a platinum catalyst, thereby a single composition can be used to coat a variety of  substances  without  need  for  changing  the  reservoir containing the coating composition.
Patent CA-2132292-A1 (CA)
Title: Process for preparing alkyl 3-hydroxy-2,4,5-trifluorobenzoates and/or alkyl 3-alkoxy-2,4,5-trifluorobenzoates
Inventor: PFIRMANN RALF
IPC: C07C69/92
Filed: 1994-09-16
Abstract: Abstract of the Disclosure:          The present invention relates to a process for preparing alkyl 3-hydroxy-2,4,5-trifluorobenzoate and/or alkyl 3-alkoxy-2,4,5-trifluorobenzoate  by  reacting  3-hydroxy-2,4,5-trifluorobenzoic acid with a dialkyl carbonate at 80 to 200°C.
Patent CA-2133805-A1 (CA)
Title: Composition for prophylaxis and treatment of myopia
Inventor: SHIGEMITSU TOSHIRO
IPC: A61K31/435
Filed: 1994-10-06
Abstract: ABSTRACT OF THE DISCLOSURE A composition for the prophylaxis and treatment of myopia, comprising a compound of the formula   wherein R is   alkyl, R1 is   hydrogen or    amino and R2 is carboxyl or tetrazolyl, or a salt thereof.  The composition for the prophylaxis and treatment of myopia of the present invention not only shows relaxing action on the ciliary smooth muscle of rabbit, but also shows superior effects of prevention and treatment of myopia of the patients on whom Mydrin-M, a conventional preparation for the prophylaxis and treatment of myopia, failed to have effects.  In addition, the comopsition does not show a mydriatic response and can be advantageously used for the prophylaxis  and treatment of myopia.
Patent CA-2134670-A1 (CA)
Title: Constitutive and inducible epidermal vector systems
Inventor: ROOP DENNIS R
IPC: A61K48/00
Filed: 1993-04-28
Abstract: A loricrin constitutive vector for efficient expression of a nucleic acid sequence in epidermal cells comprising the 5' flanking region of the loricrin gene, said flanking region containing a TATA box, a cap site and a first intron and intron/exon boundary all in appropriate sequential and positional relationship for expression of a nucleic acid cassette, a 3' flanking sequence of the loricrin gene and a linker containing a unique restriction endonuclease site at the location of the start and stop codon. Said linker connecting the 5' flanking region to the 3' flanking sequence and said linker further providing a position for inserting the cassette. The cassette contains the specific nucleic acid sequence to be expressed. Also, there is a keratin K6 inducible vector for regulating expression of a nucleic acid sequence in epidermal cells comprising the 5' flanking region of the keratin K6 gene, said flanking region including the TATA box, a cap site and the first intron and intron/exon boundary all in sequential and positional relationship for expression of a nucleic acid cassette, a 3' flanking sequence of the keratin K6 gene, and a polylinker having a plurality of restriction endonuclease sites. The polylinker connects the 5' flanking region to the 3' flanking sequence and further provides a position for insertion of the cassette. The keratin K6 and loricrin vectors can be further regulated by the addition of a Vitamin D regulatory element. The vectors can be used in a bioreactor for generating a variety of products including proteins, polypeptides or antisense RNAs. The vectors can also be used for gene therapy in treatment of a variety of diseases in animals and humans including wound healing, surgical incisions, skin ulcers, psoriasis and skin cancer, and in vaccination.
Patent CA-2137344-A1 (CA)
Title: Suds Controlling Composition Comprising Silicone and Silica
Inventor: SURUTZIDIS ATHANASIOS
IPC: C11D17/08
Filed: 1993-05-25
Abstract: The present invention provides suds controlling composition for inclusion in a detergent composition in liquid form, comprising a silicone oil/silica antifoam agent and a dispersant characterised in that the silica is absorbed with a surfactant-containing solution. The present invention also provides detergent compositions containing said suds controlling compositions.
Patent CA-2138321-A1 (CA)
Title: Device for opening a foodstuff package
Inventor: JOENSSON LEIF
IPC: B65D39/08
Filed: 1994-12-16
Abstract: An opening device for a liquid package which is attached to the top (1) of the package is provided with a screw cap (41) and a cylinder jacket shaped supporting ring (7).   In order to improve such a device to the effect that it is easier to manufacture, simpler to open and in no respect affects the quality of sealing of the package,it is provided according to the invention that the cylinder jacket shaped supporting ring (4) is attached to the top (1) of the package (2) by means of a fixing flange (5) externally surrounding an opening disc, is provided on its inner surface (12) with a raised thread (13) and surrounds the external thread (16) of the screw cap (41 ) formed from plastics material and that a cutter (18)is integrally moulded onto the free edge (17) of the screw cap (41), which is provided with a front cutting edge (19) which passes at an angle through the free edge (17).
Patent CA-2141250-A1 (CA)
Title: Airport runway or taxiway light fixture
Inventor: BARROW FRED R
IPC: B64F1/18
Filed: 1995-01-27
Abstract: A light fixture for mounting in an airport runway or a taxiway has a cover with a flat surface and one or two windows for the passage of a light beam. An optical prism is detachably mounted in a cavity formed in the cover beside and beneath each window. The prism has three flat sides forming an equilateral triangle with two of the sides sloping upwardly to a top edge positioned at a top of its window. A special sealing member fits over the prism and preferably covers one of the two sides which slope upwardly. This member extends about a lower portion of the prism and forms a water tight seal. An electric light is mounted in a bottom receptacle on which the cover is supported. A light channel is formed in the top of the cover and extends from each window towards an edge of the cover. This channel has a bottom which slopes at a small angle to the flat top.
Patent CA-2144407-A1 (CA)
Inventor: BERBE CHARLES B
IPC: A61K31/445
Filed: 1993-09-10
Abstract: An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation. <IMAGE>   <IMAGE>
Patent CA-2144832-A1 (CA)
Title: Capacitive pressure sensors or capacitive differential pressure sensors
Inventor: LANGE JUERGEN
IPC: G01L13/06
Filed: 1995-03-16
Abstract: In order to avoid short-circuits between the electrodes, the pressure sensor comprises: a substrate (11) made of ceramic material, on one surface of which an electrode (13) and a glass layer (14) formed from an original glass frit are disposed; a diaphragm (12) made of ceramic material, which is permanently joined and pressure-sealed to the substrate by means of the original glass frit acting as a spacer (17) holding the diaphragm and the substrate from each other to form a cavity (16), and which on the cavity side is provided with an electrode (15); and leads (18, 19) which extend inwards and/or through the diaphragm (12) to the electrodes (13, 15) in the region of the spacer (17).      The differential pressure sensor is formed in a mirror-inverted arrangement in relation to the centre plane of the substrate, so that it carries two pressure sensors. These are pressure-linked by a hole (41) filled with oil and connecting the two cavities and leading through the substrate and outwards. In a further development, thin insulating layers (20; 40, 40') made of the material of the ceramic of the substrate or of a high-temperature glass can be fixed on the glass layer(s), respectively.
Patent CA-2146512-A1 (CA)
Title: Process for the production of isocyanates and for the production of light colored foams therefrom
Inventor: BUYSCH HANS-JOSEF
IPC: C07C263/10
Filed: 1995-04-06
Abstract: Isocyanates or isocyanate mixtures which contain no appreciable amounts of color causing materials are produced by phosgenating the amine corresponding to the desired isocyanate and treating the isocyanate-containing phosgenation mixture with hydrogen in the presence of a supported catalyst. The supported catalyst is in a form such that its shortest dimension is from about 0.3 to about 3.0 mm. This catalyst has a BET surface of from about 0.5 to about 150 m2/g. No alkali material can be present in the catalyst. These isocyanates are particularly useful for the production of light-colored foams.
Patent CA-2147893-A1 (CA)
Title: Enantiomerically pure .beta.-d-dioxolane nucleosides with selective anti-hepatitis .beta. virus activity
Inventor: SCHINAZI RAYMOND P
IPC: C07D473/02
Filed: 1993-10-28
Abstract: A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a  beta -dioxolanyl purine nucleoside of the formula:   <IMAGE>   wherein R is OH, Cl, NH2, or H, or a pharmaceutically acceptable salt or derivative of the compound, optionally in a pharmaceutically acceptable carrier or diluent.
Patent CA-2148210-A1 (CA)
Title: Wave soldering apparatus and process
Inventor: NAYAR HARBHAJAN S
IPC: B23K3/06
Filed: 1995-04-28
Abstract: A wave soldering process and apparatus in which a localized low oxygen-containing atmosphere is provided at the point of contact of the solder wave and the substrate to be soldered by bubbling an inert gas through the solder wave.
Patent CA-2151126-A1 (CA)
Title: Peptides from the c33 region of hcv, antibodies thereto and methods for the detection of hcv
Inventor: HABETS WINAND JOHANNES ANTONIU
IPC: C12N5/10
Filed: 1993-12-07
Abstract: The invention concerns peptides which react immunochemically with antibodies directed against HCV. A preferred peptide according to the invention comprises an HCV specific epitope of the NS-3 protein. The invention further relates to antibodies that specifically react with the NS-3 protein of HCV. Methods for the detection of HCV or HCV antibodies, and a method for the detection of antibodies specifically reactive with the NS-3 antigen are also part of the present invention.
Patent CA-2151233-A1 (CA)
Title: Combined force transducer and temperature sensor
Inventor: HULSING RAND H II
IPC: G01P15/097
Filed: 1993-12-08
Abstract: A combined transducer that measures force or displacement and temperature utilizes a pair of vibrating times to provide a simultaneous output representative of temperature and force or displacement whereby the sun or average of the vibrating frequencies of the times is representative of temperature and the difference is representative of force or displacement.
Patent CA-2152760-A1 (CA)
Title: Method for reducing microfoam in a spray-applied waterborne thermoset composition
Inventor: LARSON GARY ROBERT
IPC: C09D5/00
Filed: 1995-06-27
Abstract: A method for reducing the amount of microfoam in a spray-applied clear waterborne thermoset composition is provided, wherein the clear composition contains an emulsion-polymerized addition polymers or a multi-staged emulsion-polymerized addition polymers with an average particle diameter greater than about 120 nanometers and bearing at least two first reactive groups and a reactive modifier bearing at least two reactive groups is formed; is spray-applied to a substrate; and is cured. Also provided are substrates bearing such spray-appliedclear compositions.
Patent CA-2155330-A1 (CA)
Title: Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
Inventor: ELLIOTT KATHRYN J
IPC: C12P21/08
Filed: 1994-03-08
Abstract: Nucleic acids encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said nucleic acids, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha.4 and .alpha.7) and beta subunits (specifically (.beta.4) are provided. In addition, combinations of subunits (i.e., .alpha.1, .alpha.2, .alpha.3, .alpha.4, and/or .alpha.7 subunits in combination with .beta.4 subunits; or (.beta.2, .beta.3 and/or .beta.4 subunits in combination with .alpha.4 and/or .alpha.7 subunits) are provided.
Patent CA-2155610-A1 (CA)
Inventor: POOLE NORMAN G
IPC: B65G47/88
Filed: 1995-08-08
Abstract: Apparatus for stopping articles moving along a path comprises a support, and first and second stop members mounted on the support for movement generally transversely of the path alternately toward each other to stop movement of an article along the path and away from each other to permit movement of an article past the first and second stop members.  A pair of wheels are positioned beyond the limits of travel of the first and second stop members away from each other.  A roller chain is trained about the wheels and has first and second bights extending generally transversely of the path.  The first stop member is coupled to the first bight, and the second stop member is coupled to the second bight.  A prime mover is coupled to the chain.  Actuation of the prime mover in a first direction causes the chain to move the first and second stop members toward each other and actuation of the prime mover in a second direction causes the chain to move the first and second stop members away from each other.