Patent SG-11201900170V-A (SG)
Title: Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof
Inventor: GOH SHIREEN
IPC: B01L3/00
Filed: 2017-07-21
Abstract: WO 18/0 17 0 22 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) W I PO I PCT Iiiimmommionotioloommolomonomoinovoimill (10) International Publication Number WO 2018/017022 Al (51) International Patent Classification: BOIL 3/00 (2006.01) BOlD 43/00 (2006.01) (21) International Application Number: PCT/SG2017/050373 (22) International Filing Date: 21 July 2017 (21.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201606028T 21 July 2016 (21.07.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: GOH, Shireen; c/o Bioprocessing Technolo- gy Institute, 20 Biopolis Way, Centros #06-01, Singapore 138668 (SG). TAN, Shan Mei; c/o Bioprocessing Technol- ogy Institute, 20 Biopolis Way, Centros #06-01, Singapore 138668 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: APPARATUS FOR OUTER WALL FOCUSING FOR HIGH VOLUME FRACTION PARTICLE MICROFILTRATION AND METHOD FOR MANUFACTURE THEREOF 300 FIG. 3 (57) : An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such mi- crofiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each includ- ing a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles. [Continued on next page] WO 2018/017022 Al IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIH IIII00 IIIIIIIIIIIII01101OHOIIIIIIIIIMOIIIIII SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))