baber/WOPTO huggingface dataset:
Patent DE-69110519-T2 (DE)
Inventor: SCHALLY ANDREW V
IPC: A61P35/00
Filed: 1991-03-27
Granted: 1995-11-30
Abstract: There are disclosed two, cytotoxic, structurally closely related groups of compounds, namely compounds of the formula: <IMAGE> wherein R<1> is L or D-Phe, D-Trp, L or D-Mel, R<3> is Mel, Tyr or Phe, R<6> is Thr or Val,  R<8> is Thr, Trp or Mel, Q is selected from the group consisting of hydrogen, L and D-Mel, Mel-Mel dipeptide, cyclopropanealkanoyl, aziridine-2-carbonyl, methotrexoyl, 1,4-naphthoquinone-5-oxycarbonylethyl, epoxyalkyl and the  OMEGA -carbonyl-alkylamino derivatives thereof; and the  OMEGA -carbonyl-alkanoyl derivatives of 2-hydroxymethyl-anthraquinone, doxorubicin, esperamycin, and mitomycin C ; wherein the  OMEGA -carbonyl-alkylamino group has the formula -CO-(CH2)n-NH- where n is 2-6, and the  OMEGA -carbonyl-alkanoyl group has the formula -CO-(CH2)n-CO- where n is 2-6, and compounds of formula <IMAGE> wherein R<1> is L or D-Phe, L or D-Trp, R<3> is Phe or Tyr, R<6> is Val or Thr, R<8> is Thr or Trp, A is a diaminoacyl residue having the formula -HNCH2-(CH2)m-CH(NH)-(CH2)n-CO- where m is 0 or 1 and n is 0 or 1, Q<1> is a cytotoxic moiety having the formula Q<2> or (B)2Q<3> or (Q<4>)2 wherein Q<2> is Pt(Y)2, where Y is an anion of pharmaceutically acceptable acid, Q<3> is a non-platinum-group metal, selected from the group consisting of titanium, vanadium, iron, copper, cobalt, gold, nickel, cadmium and zinc, Q<4> is selected from the group consisting of L or D-Mel, Mel-Mel dipeptide, cyclopropanealkanoyl, aziridine-2-carbonyl, epoxyalkyl, 1,4-naphthoquinone-5-oxycarbonylethyl or the  OMEGA -carbonyl-alkylamino derivatives thereof; the  OMEGA -carbonylalkanoyl derivatives of 2-hydroxymethyl-anthraquinone, doxorubicin, esperamycin and mitomycin C, wherein the  OMEGA -carbonyl-alkylamino group has the formula -CO-(CH2)n-NH- where n is 2-6 and the  OMEGA -carbonyl-alkanoyl group has the formula -CO-(CH2)n-CO- where n is 2-6, B is a substituted aralkylidene or heteroaralkylidene selected from the group consisting of halo and nitrophenyl lower-alkylidenes; lower alkyl hydroxymethyl or phosphoxymethyl pyridyl lower alkylidenes, wherein lower alk- means 1-6 carbon atoms and the salts thereof with pharmaceutically acceptable acids and bases.
Patent DE-69112208-T2 (DE)
Inventor: BUFFENOIR MARC
IPC: H05B6/36
Filed: 1991-05-07
Granted: 1996-05-02
Abstract: PCT No. PCT/FR91/00381 Sec. 371 Date Apr. 20, 1993 Sec. 102(e) Date Apr. 20, 1993 PCT Filed May 7, 1991 PCT Pub. No. WO91/17644 PCT Pub. Date Nov. 14, 1991.The product (11) is in relative motion in the direction (12) of its axis with respect to at least one magnetic inductor (10, 10'). The metallurgical product (11) is subjected to at least two magnetic fluxes (19, 19') having non-parallel directions which are transverse with respect to the longitudinal direction of the product (11). The heating device may advantageously consist of two C-shaped magnetic yokes (14, 14') spaced apart and angularly offset along the axial direction (12) of advance of the product (11).
Patent DE-69128694-T2 (DE)
Inventor: LUNARDON GIANFLAVIO
IPC: C08J9/02
Filed: 1991-11-14
Granted: 1998-08-27
Abstract: Described are flexible polyurethane foams having densities ranging from 15 to 60 kg/m<3> and a bearing capacity, at 40% compression, higher than 150 N, obtainable by reacting a modified polyisocyanate with a compound containing activated terminal hydrogen atoms, foaming agents different from chlorofluoroalkanes being used.
Patent DE-69203314-T2 (DE)
Inventor: WATANABE AKIHIRO
IPC: H01B17/36
Filed: 1992-09-23
Granted: 1995-12-07
Abstract: An explosion-proof porcelain housing for a gas-filled insulating apparatus comprises a a hollow porcelain housing body having a tapered inner surface, and a resin lined on the inner surface of the porcelain housing body. The thickness of the resin lining is varied depending upon the inner diameter of the porcelain housing body such that the thickness is smaller on a smaller inner diameter side and greater on a larger inner diameter side. <IMAGE>
Patent DE-69214802-T2 (DE)
Inventor: OSHLACK BENJAMIN
IPC: A61K47/44
Filed: 1992-11-25
Granted: 1997-05-07
Abstract: (A) Controlled release oxycodone formulation for oral admin. to human patients, comprises (i) 10-40mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-60 ng/ml from a mean of 2-4.5 hrs.. After admin., and a mean min. plasma conc. of 3-30 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady state conditions. (ii) 10-160 mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin., and a mean min. plasma conc. from 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions. (B) Also claimed is a solid controlled release oral dosage form comprising (i) oxycodone or its salt in amt. of 10-160 mg; a controlled release matrix selected from hydrophilic hydrophobic polymers, digestible opt. substd. 8-50C hydrocarbons, and/or polyalkylene glycols; and a diluent; wherein the compsn. provides a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin, and mean min. plasma conc. of 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions; or (ii) an analgesically effective amt. of spheroids comprising oxycodone or its salt and either a spheronising agent or an acrylic polymer or copolymer, such that the total dosage of oxycodone in the dosage form is 10-160 mg; a film coating which controls the release of the oxycodone or its salt at a controlled rate in an aq. medium, wherein the compsn. provides an in vitro dissolution rate of the dosage form.
Patent DE-69230506-T2 (DE)
Inventor: SOBOL ROBERT
IPC: A61K38/21
Filed: 1992-10-23
Granted: 2000-06-21
Abstract: A novel method of tumor immunotherapy is described comprising the genetic modification of cells resulting in the secretion of cytokine gene products to stimulate a patient's immune response to tumor antigens. In one embodiment, autologous fibroblasts genetically modified to secrete at least one cytokine gene product are utilized to immunize the patient in a formulation with tumor antigens at a site other than an active tumor site. In another embodiment, cells genetically modified to express at least one tumor antigen product and to secrete at least one cytokine gene product are utilized in a formulation to immunize the patient at a site other than an active tumor site.
Patent DE-69231093-T2 (DE)
Inventor: ROTH CLAUDE
IPC: C12N5/0786
Filed: 1992-11-13
Granted: 2001-02-01
Abstract: Composition designed to treat human or animal organisms comprising cells expressing genes enabling them to secrete in vivo one or more biologically-active substances, said cells exhibiting genetic characteristics preventing them from growing durably in the treated organism, and making them susceptible to elimination artificially or naturally from the organism. These compositions can be used in particular in the treatment of tumors or cancers, in which case the substances used are interleukins. The cells contained in these compositions are at least partially allogenic or xenogenic.
Patent DE-69233010-T2 (DE)
Inventor: SIMMS J
IPC: A61K35/12
Filed: 1992-07-14
Granted: 2004-02-19
Abstract: Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a DNA sequence which is expressed by the cell and which codes for a protein having complement inhibitory activity and which provides protection against complement-based lysis, i.e. hyperacute rejection. In addition, the cell's natural genome is changed so that proteins encoded by the class I or class II major histocompatability complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
Patent DE-69300334-T2 (DE)
Inventor: DI MILIA EDWARD S
IPC: G01N5/02
Filed: 1993-01-12
Granted: 1996-04-18
Abstract: A system for monitoring changes in the amount of contaminants present in a flowing stream of supercritical fluid. A sample stream is removed from a flowing stream of supercritical fluid and subjected to reduced pressure. The supercritical fluid turns into gas at the reduced pressure with the contaminants remaining in a non-gaseous form. A quartz crystal microbalance system measures changes in the amount of non-gaseous contaminants present in the sample stream. The system is useful in monitoring both cleaning processes and extraction processes utilizing supercritical fluids. <IMAGE>
Patent DE-69300981-T2 (DE)
Inventor: WRIGHT ROBERT W
IPC: B21G3/24
Filed: 1993-01-09
Granted: 1996-08-01
Abstract: Nails (12) having radially offset, circular heads (18) are manufactured from a malleable wire (20). The wire (20) is clamped so that a leading portion (20b) extends axially from a clamping mechanism (30,32). The extending portion (20a) is bent at an acute angle relative to a clamping axis. The extending portion (20a) is cut so as to form a pointed end (16) thereon and so as to leave a bent stub (20c) extending at such an angle. Such a nail head (18) is formed from the stub (20c), which is pressed by a punch (26) into a cavity (50) defined by the clamping mechanism (30,32), and which is deformed when pressed thereinto. The cavity (50) has a fully circular, offset margin. The punch (26) has a face covering the cavity (50). Once released, the wire (20) is fed axially until a leading portion (20b) extends as before. These operations are repeated to form a similar nail (12) in each repetition. A novel apparatus (10) for carrying out these operations is disclosed. <IMAGE>
Patent DE-69320671-T2 (DE)
Inventor: ADAMS STEPHEN M
IPC: G11B20/12
Filed: 1993-02-22
Granted: 1999-02-04
Abstract: A method for formatting a length of magnetic tape into a plurality of partition areas (100,110,118,126,120) to enable data storage in any of these areas and for formatting on the magnetic tape a plurality of spaced system zones (102,114,122), by means of controlling programs of a recording device prompting a host computer system to input the number and spacing of the system zones and the length and number of the partitions to be formatted onto the magnetic tape. The programs also prompts the host computer system to select one of various options (7A,7B,7C) for placing a partitions on the magnetic tape. <IMAGE>
Patent DE-69325285-T2 (DE)
Inventor: BARLOW IAN
IPC: C09D5/02
Filed: 1993-10-26
Granted: 1999-09-30
Abstract: Aqueous oil-in-water emulsion scratch cover compositions for covering scratches, blemishes and other damage to finished wooden articles such as furniture, wooden trim and wooden floors with characteristcs comparable to volatile organic solvent-based scratch cover compositions are described which are substantially free of added volatile organic solvents and conventional surfactants. These emulsion compositions comprise 2-10 % of an animal, vegetable or mineral oil that is a liquid and substantially nonvolatile at 25  DEG C, 0.0001-1 % of at least one organic solvent soluble dye that is soluble in the oil and is substantially water insoluble, an effective amount, preferably 0.01-5 %, of a polymeric electrostatic emulsifier such as an acrylates/C10-C30 alkyl acrylate cross polymer that takes the place of conventional surfactants with the balance comprising water, and optionally, nonionic waxes, nonionic nonvolatile silicone fluids, pigments or no more than about 1 % of nonionic surfactants.
Patent DE-69331531-T2 (DE)
Inventor: CLARKSON A
IPC: D06L4/70
Filed: 1993-11-30
Granted: 2002-07-11
Abstract: During the desizing and enzymatic stonewashing of denim fabric and/or garments, redeposition of blue color often occurs back onto the surfaces of the denim. The invention relates to a redepositing or backstain inhibiting composition and a method requiring the inclusion of an added protease prior to, during or subsequent to the stonewashing process which reduces the redeposition of the blue dye and hence improves the stonewashing process when using redepositing or backstaining cellulases to give an appearance closer to that when using stones alone or nonredepositing cellulases in the stonewashing process.
Patent DE-69333274-T2 (DE)
Inventor: FOSTER L DALE
IPC: A61B19/02
Filed: 1993-04-14
Granted: 2004-08-26
Abstract: A hospital bed 100 supported on a wheeled base 104, and a ventilator 26 supported on a wheeled cart 18 and docked to the base 104 of the bed 100, the combination of ventilator 26 and bed 100 capable of being rolled as a single unit. The ventilator cart 18 includes a wheeled base 20, and supports 24, 24 connected to the base 20 for supporting a ventilator 26, with the supports 24, 24 providing for selective raising and lowering of the ventilator 26. The hospital bed base 104 is wheeled and has a generally Y-shaped base frame 110. The outspread arms 112, 112 of the Y-shaped base frame 110 receives the ventilator cart 18 so that the two may be docked together. The ventilator 26 when docked to the hospital bed base 104 falls within the footprint 126 of the bed 100 as projected downwardly onto the floor. A latch 118, 120 secures the ventilator 26 to the bed base 104. A disabling switch 120 disables the high/low function of the bed 100 preventing the bed 100 from being lowered downwardly onto the ventilator 26. A power supply 122 mounted to the bed base 104 provides for uninterrupted operation of the ventilator 26. <IMAGE>
Patent DE-69411492-T2 (DE)
Inventor: ROMERS ERIC
IPC: C07B61/00
Filed: 1994-10-14
Granted: 1998-11-26
Abstract: Medium-chain olefins containing as impurities 2-alkyl substituted isomers having a close boiling point are purified by (i) passing over a solid acid catalyst under mild conditions to selectively double-bond isomerise said impurities, and (ii) separating said isomerised olefins by distillation.
Patent DE-69415070-T2 (DE)
Inventor: SCOTT GARRETT L
IPC: C03B7/086
Filed: 1994-04-15
Granted: 1999-06-24
Abstract: A multiple glass feed system for use with a glass forehearth including a plurality of closely spaced plungers (12), each of which is individually adjustged independently of the other. The upper portions (14) of the plungers (12) are provided in side-by-side relation and supported by clamping mechanism (16) which comprise a chuck housing (21) and a clamping liner plate (24).
Patent DE-69429434-T2 (DE)
Inventor: BERRIGAN THOMAS JOHN
IPC: A61M5/145
Filed: 1994-08-11
Granted: 2002-08-22
Abstract: A drug delivery device comprising a holding reservoir, a pump, a delivery reservoir and an outlet.
Patent DE-69433969-T2 (DE)
Inventor: MISAWA NORIHIKO
IPC: C12N15/53
Filed: 1994-12-26
Granted: 2005-08-11
Abstract: Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering: A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a  beta -ionone ring into a keto group. A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy- beta -ionone ring into a keto group. A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto- beta -ionone ring. It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.
Patent DE-69503826-T2 (DE)
Inventor: WHA SEOP LEE WHA SEOP LEE
IPC: D01F2/00
Filed: 1995-04-25
Granted: 1999-04-22
Abstract: There is disclosed a method for purifying a used aqueous N-methylmorpholine N-oxide solution reclaimed from a spinning aqueous solution, which results from a coagulation solution into which a cellulose dope containing N-methylmorpholine N-oxide is extruded through a spinning die and from a washing solution for the coagulated cellulosic articles in manufacture processes for cellulose fibers or films, comprising adding an oxidant to the used aqueous N-methylmorpholine N-oxide solution to remove impurities therefrom through oxidizing N-methylmorpholine to N-methylmorpholine N-oxide and break down of the chromophores of the impurities. Utterly distinguished from conventional methods in the principle, the method is very simple and efficient as well as far superior to the conventional methods using ion exchange resin in the decoloration. In addition, it needs not suffer a loss of amine oxide as usual in the ion exchange resin. Further, the oxidant can achieve the decolorization without influence of the concentration of amine oxides. The amine oxide decolorized by the oxidant may be used to prepare the cellulose dope without any more purification. Provided that sequential use of the oxidant and the resin or active carbon, there are brought about much higher efficiency as well as much purer aqueous amine oxide solution.
Patent DE-69504779-T2 (DE)
Inventor: NIJZINGH JOHAN RONALD
IPC: A47J43/044
Filed: 1995-01-31
Granted: 1999-04-22
Abstract: A kitchen machine is provided with a base (3) and a motor housing (5) which is arranged on the base (3) and in which an electric motor (27) is accommodated. On the base (3) next to the motor housing (5), an open bowl (9) can be placed, journalled relative to the base (3). A transverse arm (17) can be coupled on the motor housing (5), which arm extends to above the bowl (9). A tool (19) can be placed in the bowl (9) and can be coupled to a transmission (25) which is arranged in the transverse arm (17) and can be driven by the electric motor (27). The bowl (9) can be driven into rotation by a pinion (21) which is also coupled to the transmission (25). The pinion (21) is displaceable along its axis of rotation relative to the transverse arm (17) and is displaced from a first into a second position through engagement with a toothed rim (23) of the bowl (9) when the transverse arm (17) is placed on the motor housing (,5). In the first position of the pinion (21), a rotary switch (69) is blocked in its zero position by a blocking mechanism (71) coupled to the pinion (21), so that the electric motor (27) cannot be switched on, whereas the rotary switch (69) is released by the blocking mechanism (71) with the pinion (21) in the second position when the transverse arm (17) is locked to the motor housing (5) by a locking mechanism (117). The kitchen machine can thus only be switched on when both the bowl (9) and the transverse arm (17) have been correctly positioned, so that the possibility of injury of a user of the kitchen machine with the rotating parts of the kitchen machine is substantially elminated.
Patent DE-69508770-T2 (DE)
Inventor: GITZHOFER FRANCOIS
IPC: C23C4/12
Filed: 1995-08-28
Granted: 1999-10-21
Abstract: The plasma spray method produces a material deposit on a substrate to form either a protective coating of a near net shape body, or produces a powder of a given material. The material is supplied to a plasma discharge in the form of a suspension comprising small solid particles of that material dispersed into a liquid or semi-liquid carrier substance. The suspension is brought into the plasma discharge by an atomizing probe using a pressurized gas to shear the suspension and thus atomize it into a stream of fine droplets. The plasma discharge vaporizes the carrier substance and agglomerate the small solid particles into partially or totally melted drops which are accelerated to hit the substrate and form thereon the coating or near net shape body. Alternatively, the molten drops can be solidified in-flight and collected into a vessel to produce a powder of that material.
Patent DE-69513529-T2 (DE)
Inventor: CHIES EZIO
IPC: E05B47/00
Filed: 1995-07-14
Granted: 2000-05-18
Abstract: An electromechanically operated cylinder-key unit for locks characterised by comprising in combination: a cylinder (2, 102) with a pawl (6, 106) rotatable mechanically by a key (4, 104), a key (4, 104) provided with its own identification code and control logic (46, 146), electrical-contactless coupling means (40, 48, 140, 148) between said key (4, 104) when inserted into the cylinder (2, 102) and the cylinder itself, a permanent magnet (18, 118) housed within said cylinder and rotatable by the key (4, 104), a magnetic circuit associated with said permanent magnet (18, 118), a winding (22, 122) housed in the cylinder (2, 102) and linked with said magnetic circuit, means (12, 64) for achieving mechanical coupling between the key (4, 104) and the pawl (6, 106), control logic (26, 126) housed in the cylinder (2, 102) and provided with an identification code for said cylinder, and interacting via said electrical-contactless coupling means (40, 48) with the control logic (46, 146) of the key (4, 104) when inserted into the cylinder, an electromechanical member (30, 31, 130, 131, 76, 78) for carrying out the mechanical rotational connection between the key (4, 104) and the pawl (6, 106) on recognizing correspondence between said key and said cylinder.
Patent DE-69514630-T2 (DE)
Inventor: KAWAMURA MAKOTO
IPC: H04N5/85
Filed: 1995-11-29
Granted: 2000-05-31
Abstract: High-speed access to a multi-layered disk is to be realized. Each layer on a multi-layered disk may include an inside guard area 2, program area 3, and outer guard area 5 which are located in uniform radial positions in all layers. The uppermost layer has the recording direction from the inner side to the outer side of the disk, and the next layer has the recording direction from the outer side to the inner side of the disk such that opposite recording directions appear alternately. The radial position of the recording terminal end on the uppermost first layer may coincide with the radial position of the start of record on the next second layer. Recording and/or playback apparatus for such recording media is also provided. <IMAGE>
Patent DE-69519581-T2 (DE)
Inventor: KAMODA OSAMU
IPC: C07C69/94
Filed: 1995-08-30
Granted: 2001-05-31
Abstract: The present invention is related to novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof, anti-helicobacter pylori agents comprising one or more compounds of the present invention, and also pharmaceutically compositions for anti-Helicobacter pylori comprising one or more compounds of the present invention and pharmaceutically acceptable carries.
Patent DE-69527178-T2 (DE)
Inventor: BERTHE CHRISTIAN
IPC: A61B5/22
Filed: 1995-04-19
Granted: 2003-01-30
Abstract: PCT No. PCT/BE95/00037 Sec. 371 Date Feb. 28, 1996 Sec. 102(e) Date Feb. 28, 1996 PCT Filed Apr. 19, 1995 PCT Pub. No. WO95/28882 PCT Pub. Date Nov. 2, 1995A table with a top panel 10 attached to a frame 14 mounted on runners and slidable along a supporting underframe 16 on a base. The top panel consists of a back rest 11 and a seat 12 mutually pivotable about a hinge 13 fastened to the frame. The back rest and the seat are connected to devices 17, 18 attached to the underframe for adjusting the tilt of the back rest and the seat. The ends of the underframe are mounted on two posts so that it is tiltable thereon about a longitudinal pivot axis, and a pedal assembly 20 is attached to said underframe.
Patent DE-69530552-T2 (DE)
Inventor: TSOU HWEI-RU
IPC: A61P35/00
Filed: 1995-10-26
Granted: 2003-11-20
Abstract: This invention provides novel antitumor agents having the formula:   <CHEM> wherein A, B, G, W, R<1>, R<2>, R<3>, n, m and Z are described in the specification which have activity as anticancer agents and inhibit leukemia and solid tumor growth in a mammal.