baber/WOPTO huggingface dataset:
Patent CA-3035371-A1 (CA)
Inventor: LOUKAS ALEX
IPC: C07K14/475
Filed: 2017-09-04
Abstract: Peptides derived from the N-terminal region of granulin have activity in promoting cell proliferation, migration and/or wound healing. Furthermore, an additional disulphide bond may be engineered into such peptides to improve or otherwise modify the folding of the peptide. The peptides may also be modified such as at proline residues improve the ability of the peptide to promote cell proliferation.
Patent CA-3035937-A1 (CA)
Inventor: VUCAK MARIJAN
IPC: C08J3/20
Filed: 2017-09-07
Abstract: The invention relates to a composite powder having microstructured particles, obtainable by a method wherein large particles are connected to small particles, wherein the large particles have an average particle diameter in the range from 0.1 µm to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and/or inhomogeneously distributed within the large particles, the small particles comprise spherical precipitated calcium carbonate particles having an average diameter in the range from 0.05 µm to 50.0 µm, wherein the spherical calcium carbonate particles are obtainable by a method wherein a. a calcium hydroxide suspension is provided, b. carbon dioxide or a gas mixture containing carbon dioxide is introduced into the suspension from step a. and c. occurring calcium carbonate particles are separated, wherein 0.3 wt% to 0.7 wt% of at least one aminotrialkylene phosphonic acid is furthermore added. Preferred application areas of the composite powder comprise the use thereof as an additive, in particular as a polymer additive, as an additive material or starting material for compounding, for the production of components, for applications in medical technology and/or in microtechnology and/or for the production of foamed objects. The invention thus further relates to components which are obtainable by selective laser sintering of a composition, comprising a composite powder according to the invention, except implants for applications in the fields of neurosurgery, oral surgery, maxillofacial surgery, neck surgery, nasal and ear surgery, and hand, foot, thoracic, rib, and shoulder surgery. The invention further relates to the spherical calcium carbonate particles that can be advantageously used for producing the composite particles according to the invention, and to the use thereof.
Patent CA-3036710-A1 (CA)
Inventor: ZANGI LIOR
IPC: A61K48/00
Filed: 2017-09-18
Abstract: La présente invention concerne un système de régulation d'expression pour la transcription (expression) spécifique à une cellule d'une protéine d'intérêt, par exemple un inducteur de cycle cellulaire qui réactive la prolifération dans des cardiomyocytes ou des cellules bêta productrices d'insuline adultes ou néonataux. Le système de régulation d'expression comprend un premier acide nucléique qui code un élément de reconnaissance de microARN qui se lie spécifiquement à un miR de cellule cible, et une protéine de suppression de traduction ; et un deuxième acide nucléique qui comprend un motif d'interaction de protéine de suppression qui se lie à la protéine de suppression de traduction, et un gène qui code pour une protéine d'intérêt. Lorsqu'une cellule d'intérêt est co-transfectée avec les premier et deuxième acides nucléiques du système, la protéine d'intérêt est exprimée de façon spécifique à une cellule.
Patent CA-3037758-A1 (CA)
Inventor: MONNIER PHILIPPE PATRICK
IPC: A61K39/395
Filed: 2016-09-23
Abstract: Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include RGMa, soluble RGMa, and functional fragments and variants thereof, RGMc, soluble RGMc, and functional fragments and variants thereof, and Neogenin peptides including 4Ig.
Patent CA-3038825-A1 (CA)
Title: Endovascular prosthesis delivery device
Inventor: FUNG ERIC SOUN-SANG
IPC: A61M25/18
Filed: 2017-09-29
Abstract: There is described an endovascular prosthesis delivery device. The subject endovascular prosthesis delivery device comprises a combination of a delivery frame element and a hub insert element that are secured to one another by a first retention element. At a distal portion of the delivery frame element, there is a prosthesis attachment zone for coupling to an endovascular prosthesis. When it is desired to deploy the endovascular prosthesis, the first retention element is broken in a manner to allow relative movement between the hub insert element and the delivery frame element. A pull wire assembly is secured with respect to the hub insert element and comprises a pull wire which is coupled to the endovascular prosthesis in the prosthesis attachment zone of the delivery frame element. Once the first retention element is broken by the physician (this is done when the endovascular prosthesis is in the correct position for deployment), the physician can then retract the hub insert which has the effect of retracting pull wire from the prosthesis attachment zone of the delivery frame element. The endovascular prosthesis and the endovascular prosthesis delivery device are now detached from one another and the latter may be withdrawn from the patient.
Patent CA-3042147-A1 (CA)
Title: Material for use in lining large-diameter pipes and a method of making same
Inventor: TOUGH DAVID
IPC: B29C65/62
Filed: 2017-10-31
Abstract: A material for use in lining large-diameter pipes is disclosed. A textile material formed to a tubular shape and impregnated with resin may, on curing the resin, repair a damaged pipe in a cure in place pipe (CIPP) rehabilitation process. The present invention provides both a novel structure of tubular material and a novel method of preparing the material for use in a CIPP rehabilitation process, specifically aimed at large-diameter pipes such as oil rig caissons. The tubular material of this invention comprises four sheets of a double-bed warp-knitted fabric (40). A first pair of sheets (52) are arranged to form, respectively,inside and outside surfaces of a first half-tube,with fabric machine direction extending along the length of the half-tube. The second pair of sheets (52a) are similarly arranged to form a second half-tube. The two half-tubes are connected at a pair of longitudinally extending joins (58, 60). The preparation process includes stabilising tensioned sheets with a mesh layer (44), which makes for better handling of the knitted fabric.
Patent CA-3042679-A1 (CA)
Title: Activatable anti-ctla-4 antibodies and uses thereof
Inventor: TIPTON KIMBERLY ANN
IPC: A61P35/00
Filed: 2017-11-02
Abstract: Provided herein are activatable anti-human CTLA-4 antibodies comprising a heavy chain comprising a VH domain and a light chain comprising a masking moiety (MM), a cleavable moiety (CM), and a VL domain. Such activatable anti-human CTLA-4 antibodies have CTLA-4 binding activity in the tumor microenvironment, where the masking moiety is removed by proteolytic cleavage of the cleavable moiety by tumor-specific proteases, but exhibit greatly reduced binding to CTLA-4 outside the tumor. In this way, the activatable anti-human CTLA-4 antibodies of the present invention retain anti-tumor activity while reducing the side effects associated with anti-CTLA-4 activity outside the tumor.
Patent CA-3045694-A1 (CA)
Title: Production de messages de routage pour des communications par voix sur ip
Inventor: PERREAULT CLAY
IPC: G06F16/30
Filed: 2007-11-01
Abstract: Lacheminement dune communication entre un premier et un deuxième participant comprend la réception par un contrôleur sur un réseau IP, de la part dun premier dispositif participant, dun identifiant du premier participant et dun identifiant du deuxième participant pour trouver respectivement le profil du premier et du deuxième participant. Au moins une partie de lidentifiant du deuxième participant est comparée à au moins un attribut contenu dans le profil utilisateur du premier participant et, selon la comparaison, la communication est classée comme communication de système ou comme communication de réseau externe, selon laquelle un message dacheminement de système déterminant une adresse IP dun nud de système de communication associée au dispositif du deuxième participant en fonction de son profil utilisateur est produit, ou un message dacheminement de réseau externe déterminant une adresse IP dune passerelle à un réseau externe est produit. Le message dacheminement produit indique ainsi la façon dont la communication doit être acheminée.
Patent CA-3045892-A1 (CA)
Inventor: O'SHEA CLODAGH
IPC: A61K35/761
Filed: 2017-12-11
Abstract: Synthetic adenoviruses with liver detargeting mutations and expressing an adenovirus type 34 (Ad34) fiber protein, or a chimeric fiber protein with an Ad34 knob domain, are described. The synthetic adenoviruses traffic to sites of tumors. Use of the synthetic adenoviruses for delivering diagnostic or therapeutic transgenes to tumors are also described.
Patent CA-3049991-A1 (CA)
Title: Nucleoside-modified rna for inducing an immune response against zika virus
Inventor: WEISSMAN DREW
IPC: A61K39/12
Filed: 2018-01-11
Abstract: The present invention relates to compositions and methods for inducing adaptive immune response against Zika virus (ZIKV) in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside- modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof.
Patent CA-3053442-A1 (CA)
Inventor: LEBREUX NORMAND
IPC: F02N11/04
Filed: 2017-05-12
Abstract: A method and a system for starting an internal combustion engine (ICE) having a crankshaft and an electric turning machine (ETM) operatively connected to the crankshaft are disclosed. An absolute angular position of the crankshaft related to a top dead center position of a piston in a combustion chamber of the ICE is determined. Electric power is delivered to the ETM at a first level to rotate the crankshaft. Electric power is then delivered to the ETM at a second level greater than the first level when the piston reaches a predetermined position before the TDC position. Fuel is injected in the combustion chamber after the piston has passed beyond the TDC position. The fuel is then ignited. In an implementation, the ICE is started in less than 110 degrees of rotation of the crankshaft.
Patent CA-3053466-A1 (CA)
Title: Method and device for measuring the shape, dimensions and elasticity of shoes
Inventor: CHUYKO GRIGORY VLADIMIROVICH
IPC: G01B11/24
Filed: 2017-05-25
Abstract: The present invention relates to a measurement technique, intended for measuring the shape, the inner dimensions and the elasticity of shoes. The measurement method applied consists in using probes with indicators, which create firmness on the surface to be measured. For tracing the shape of the inner surface of the shoe, a camera and a fiat marking strip are used. Based on the total of the images, a three-dimensional model of the inner surface of the shoe to be controlled is built, and the elastic properties are determined when scanning the abject with different levels of firmness of the probe. The device is comprised of a body, a camera installed therein, two or more probes with indicators and a fiat marking strip. The invention allows to increase the accuracy, to reduce both the labour intensity and measurement time.
Patent CA-3053611-A1 (CA)
Title: Appareil de canalisation ameliore
Inventor: ENSTON ROBERT PETER
IPC: F16K27/04
Filed: 2018-02-26
Abstract: L'invention concerne un appareil de canalisation qui comprend un boîtier (2) comprenant une colonne montante (2a) et un raccord de canalisation (2b), et un dispositif (3) conçu pour interagir avec un fluide s'écoulant à travers le raccord de canalisation, un moyen de montage (25) pour monter amovible le dispositif dans la colonne montante et un moyen d'étanchéité (50) situé entre une surface interne de la colonne montante et une surface externe du moyen de montage, le moyen d'étanchéité étant conçu pour assurer l'étanchéité vis-à-vis de la sortie de fluide de l'appareil, le moyen de montage et la colonne montante comprenant chacun une partie d'un moyen de verrouillage (27, 28) pour verrouiller de manière amovible le dispositif dans la colonne montante, le dispositif situé dans le raccord de canalisation.
Patent CA-3054760-A1 (CA)
Inventor: BARNETT ANNA MEGAN
IPC: G01T1/24
Filed: 2018-02-28
Abstract: A photodiode for use in detecting X-rays and/or gamma rays is disclosed. The photodiode comprises In Ga P arranged and configured to absorb X-rays and/or gamma- rays incident on the photodiode and generate charge-carriers in response thereto. The detector may be provided in an X-ray or gamma-ray photon counting spectrometer.
Patent CA-3056057-A1 (CA)
Inventor: YAMAGUCHI SHINICHI
IPC: C23C28/00
Filed: 2018-03-23
Abstract: Provided are: a base material (101); an Al-based plating layer (103) formed on at least one side surface of the base material (101); an intermediate coating film layer (105) formed on a surface of the Al-based plating layer (103); ZnO particles (109) formed on a surface of the intermediate coating film layer (105) and having an average particle diameter of 0.10 µm-5.00 µm; and a surface coating film layer (107) containing an organic resin (111) and having an adhesion amount of the ZnO particles (109) of 0.5 g/m2-10.0 g/m2. The intermediate coating film layer (105) satisfies any one of the following conditions (A) to (C). (A) The intermediate coating film layer (105) has a thickness of 10 nm-1000 nm, and contains S, Al and O as main components, wherein [S]/[Al] is 0.0008 to 0.49, and [S]/[O] is 0.001 to 0.55. (B) The intermediate coating film layer (105) contains an oxo acid salt, and the adhesion thickness thereof is 10 nm-500 nm. (C) The intermediate coating film layer (105) is a fluoride salt, and the amount of fluorine contained therein is 20 mg/m2 or more.
Patent CA-3057052-A1 (CA)
Title: Method for producing railway wheel and railway wheel
Inventor: MAEJIMA TAKETO
IPC: C22C38/00
Filed: 2018-03-30
Abstract: The present invention makes it possible to consistently produce rail wheels for which generation of pro-eutectoid cementite has been curbed. In the invention, an intermediate product having 0.80 to 1.15% C in mass% is heated to an Acm transformation point or higher, and then cooled so that the rate of cooling (°C/sec) of the intermediate product from 800°C to 500°C meets the following conditions. Surfaces other than a tread surface and flange surface: = Fn1 as defined in formula (1). Rate of cooling of a region where the rate of cooling is the slowest: = Fn2 as defined in formula (2). Tread surface and flange surface: = Fn2. Formula (1): Fn1=-5.0+exp(5.651-1.427×C-1.280×Si-0.7723×Mn-1.815×Cr-1.519×Al-7.798×V) Formula (2): Fn2=0.515+exp(-24.816+24.121×C+1.210×Si+0.529×Mn+2.458×Cr-15.116×Al-5.116×V)
Patent CA-3058072-A1 (CA)
Inventor: OLAYIWOLA BOLAJI
IPC: C07C5/48
Filed: 2019-10-09
Abstract: A process, a system, and an apparatus for separation of an oxygenate from a stream is provided. More specifically, a stream comprising the oxygenate is introduced to a quench tower along with a caustic outlet stream comprising a metal salt. Contact between the oxygenate and the metal salt results in conversion of a portion of the oxygenate into a derivative salt. The derivative salt and unconverted oxygenate are condensed by quenching and substantially removed from the quench tower as an oxygenate outlet stream. The gaseous components of the stream, minus a substantial portion of the oxygenate, are removed from the quench tower as a quench outlet stream.
Patent CA-3059070-A1 (CA)
Title: High ethylene random copolymer with non-migrating oligomers
Inventor: GANGULY RANADIP
IPC: C08J5/18
Filed: 2018-03-14
Abstract: This invention relates to the use of ethylene/propylene random copolymers for the production of films having low-haze. In particular, the present invention involves the use of ethylene/propylene random copolymer comprising 90-96.5 wt% propylene and 3.5-10 wt% ethylene demonstrated to have low haze. This invention also relates to an ethylene/propylene random copolymer composition comprising about 3.5-10 wt% ethylene content and about 90-96.5 wt% propylene content, for production of a low-haze film.
Patent CA-3067318-A1 (CA)
Title: Systems and methods for split bolus protocol generation
Inventor: VOLKAR JOHN
IPC: G16H20/17
Filed: 2018-06-14
Abstract: Described is an injector system for implementing a split bolus injection procedure. The injector system includes a processor and a non-transitory storage medium having programming instructions stored therein that, when executed by the processor, enable the injector system to operate as a parameter generation system for use in determining parameters associated with a split bolus injection protocol via which injection of the contrast agent by the injector system is controlled. The split bolus injection protocol includes at least a loading injection and a diagnostic injection, wherein the loading injection is performed before the diagnostic injection, and wherein a pause separates the loading injection from the diagnostic injection. Also described is a method for patient imaging using a split bolus injection technique and a system having an imaging device and the injector system described above.
Patent CA-3067370-A1 (CA)
Inventor: NIAZI KAYVAN
IPC: A61P35/00
Filed: 2018-06-15
Abstract: Cette invention concerne une composition pharmaceutique et des procédés d'immunothérapie. La composition pharmaceutique comprend une bactérie génétiquement modifiée exprimant un ou des antigènes liés à une maladie humaine, de préférence au moins deux antigènes tumoraux spécifiques du patient à titre de polytope. La bactérie comprend un lipopolysaccharide génétiquement modifié ou une bactérie endosymbiotique du patient de façon que la bactérie exprime une endotoxine à un faible niveau, qui est insuffisant pour induire une sepsie médiée par CD-14. La bactérie génétiquement modifiée peut être administrée au patient, par voie systémique ou locale, pour induire une réponse immunitaire spécifique de tumeur.
Patent CA-3069061-A1 (CA)
Title: Laminated glass comprising interlayer film layers with a pigmented frame
Inventor: BUTLER CHARLES
IPC: B32B17/10
Filed: 2018-08-01
Abstract: The invention is directed to Laminated glass obtained by laminating at least one film A containing a polyvinyl acetal PA and optionally at least one plasticiser WA and at least one film B containing a polyvinyl acetal PB and at least one plasticiser WB between two glass sheets, characterised in that prior to lamination; - the amount of plasticiser WA in film A is less than 22 % by weight; - the amount of plasticiser WB in film B is at least 22 % by weight and - film A comprises at least on one surface a non-transparent region.
Patent CA-3069901-A1 (CA)
Inventor: LEMIEUX ERIC
IPC: A63B71/14
Filed: 2018-07-13
Abstract: L'invention concerne un procédé de fabrication d'un gant comprenant la formation d'une base par moulage, la base étant formée pour comprendre une partie paume et une ou plusieurs parties extrémité. Le procédé comprend également la formation d'une peau supérieure par moulage, la peau supérieure comprenant un ou plusieurs compartiments, et la formation d'un ensemble revers par fixation d'un ou de plusieurs bords du ou des compartiments de la peau supérieure à la base. Au moins un bord restant de chacun du ou des compartiments n'est pas fixé à la base. Le procédé comprend également l'inversion d'une orientation de l'ensemble revers, le remplissage de chacun du ou des compartiments de la peau supérieure avec de la mousse, et la fixation du ou des bords restants de chacun du ou des compartiments à la base.
Patent CA-3079086-A1 (CA)
Inventor: HAZIZA DEDI DAVID
IPC: H01Q1/38
Filed: 2018-10-30
Abstract: L'invention concerne une antenne comprenant : une couche à constante diélectrique variable (VDC) ; une pluralité de pastilles rayonnantes disposées sur la couche VDC ; une pluralité de lignes de signal, chacune se terminant en alignement au-dessous de l'une des pastilles rayonnantes ; une pluralité de lignes de commande, chacune correspondant à l'une des lignes de signal ; un plan de masse ; la couche VDC comprenant une pluralité de sous-couches de cristaux liquides empilées les unes sur les autres.
Patent CA-3079650-A1 (CA)
Inventor: ALVAER JAN
IPC: E21B19/16
Filed: 2018-10-10
Abstract: L'invention concerne une séquence de procédé permettant de manipuler des éléments tubulaires dans ou hors d'un puits de forage, le procédé comprenant les étapes consistant : à déplacer un train de tiges tubulaire dans ou hors d'un puits de forage par un moyen d'entraînement supérieur ; à déplacer des longueurs de tiges vers et à partir d'une position de retrait et d'une position de transfert de longueur de tiges par l'intermédiaire d'un support de pont de transfert et d'un bras de guidage de retrait ; à déplacer des longueurs de tiges vers et à partir de la position de transfert de longueur de tiges et d'une position de centre de puits par l'intermédiaire d'un bras de distribution tubulaire et d'un bras de stabilisation inférieur ; à construire des longueurs de tiges et à casser des longueurs de tiges hors ligne par un trou de souris et à faire fonctionner une manuvre de sonde sur des joints entre les longueurs de tiges et le train de tiges tubulaire.
Patent CA-3081312-A1 (CA)
Inventor: WOOD JACK KINGSLEY
IPC: F41B11/52
Filed: 2020-05-21
Abstract: The latching/locking loader mechanism of the present invention provides a quick-release latch mechanism where a user can unlock and lock the attachment of the loader to the paintball gun quickly and easily without the use of tools. The latching/locking mechanism stays locked or unlocked without further use of tools. A spring-biased gate is provided in the path of the paintballs, namely, in the feed neck of the loader. When the loader is installed on the paintball marker, via a feed collar, deflection posts on the feed collar push the gate out of the paintball path in the feed neck of the loader so that paintballs may freely pass from the storage chamber of the loader and then into the breech of the paintball marker. When not installed on a feed collar, the gate blocks the path of paintballs.
Patent CA-3082182-A1 (CA)
Title: Order grouping in warehouse order fulfillment operations
Inventor: JOHNSON RYAN
IPC: G06Q10/08
Filed: 2018-11-07
Abstract: A method for grouping a plurality of orders in an order queue of a warehouse management system, each order including one or more items and each item being associated with a physical location in a warehouse. The method includes determining a physical location in the warehouse of each item in the plurality of orders. For each order, the method also includes establishing at least one cluster region, each cluster region including at least one item from the respective order. The method further includes grouping the plurality of orders based on the physical locations of the cluster regions in the warehouse to form at least one order set.