baber/WOPTO huggingface dataset:
Patent CA-3047137-A1 (CA)
Title: Poly-adp ribose polymerase (parp) inhibitors
Inventor: TAKAHASHI TAISUKE
IPC: C07D417/08
Filed: 2017-12-28
Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
Patent CA-3048859-A1 (CA)
Title: Compositions et procedes de detection d'adn tumoral circulant
Inventor: ARNAL SUZZETTE
IPC: C12Q1/6844
Filed: 2017-12-27
Abstract: La présente technologie concerne des compositions polynucléotidiques et des procédés d'utilisation de celles-ci pour détecter de l'ADN tumoral circulant (ADNtc) chez un patient. L'invention concerne également des kits destinés à être utilisés pour la mise en uvre de ces procédés.
Patent CA-3049073-A1 (CA)
Inventor: NEARY S DOUGLAS
IPC: G10D7/14
Filed: 2019-07-11
Abstract: The invention relates to improvements to harmonica holders, designed to allow a musician to play a harmonica and another instrument at the same time. The inventor's control arm and extender tubes allow a musician to adjust the position of a harmonica (in the horizontal and vertical plains) to their personal preference. After adjustment, the control arm allows a musician to quickly raise a harmonica up to their preferred position, which locks a harmonic in place and eliminates the need to re-set it each time it is used. To unlock a harmonica and drop it completely out of the way for singing or to remove it from their head area, they would simply tap the end of the control arm up, to disengage it. The neck support is also adjustable for best fit, while a pull down loop (attached to a harmonica cross member) allows a musician to quickly change harmonicas.
Patent CA-3056640-A1 (CA)
Inventor: WAGNER THOMAS
IPC: B65G1/137
Filed: 2018-03-16
Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins being in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and is adapted for movement of the programmable motion device along a first direction, and a plurality of destination bins that are provided in at least one linear arrangement along the first direction of movement of the programmable motion device.
Patent CA-3057710-A1 (CA)
Inventor: ZHA SHITONG
IPC: F25B47/02
Filed: 2019-10-04
Abstract: An apparatus includes a high side heat exchanger, a subcooler heat exchanger, a flash tank, a load, and a compressor. The high side heat exchanger removes heat from a refrigerant. The subcooler heat exchanger receives the refrigerant. The flash tank stores the refrigerant. During a first mode of operation, the load uses the refrigerant to cool a space proximate the load and the compressor compresses the refrigerant. During a second mode of operation, the subcooler heat exchanger receives the refrigerant from the flash tank, transfers heat from the refrigerant from the high side heat exchanger to the refrigerant from the flash tank and directs the refrigerant from the flash tank to the compressor. During the second mode of operation, the compressor compresses the refrigerant from the subcooler heat exchanger and directs the compressed refrigerant to the load to defrost the load.
Patent CA-3060677-A1 (CA)
Title: Thermoplastic compositions, methods, apparatus, and uses
Inventor: COLGROVE JAMES R
IPC: C08L75/04
Filed: 2018-04-27
Abstract: Thermoplastic polyurethane (TPU) compositions, methods for producing TPU  compositions, methods of using TPU  compositions, and apparatuses produced therefrom are disclosed. Disclosed TPU  compositions include a thermoplastic polyurethane polymer, a heat stabilizer, a flow agent, and a filler material. The filler may be a glass fiber. Disclosed TPU compositions have improved thermal stability and improved flow properties suitable for injection molding of articles of manufacture having a large plurality of fine openings or pores. Articles produced from the composition have superior thermal stability, abrasion resistance, and chemical resistance.  Example articles include screening members for vibratory screening machines.
Patent CA-3061490-A1 (CA)
Title: Plate-forme de diffusion et d'enrolement d'etudiant internationale
Inventor: HOEHN-SARIC RUDOLF CHRISTOPHER
IPC: G09B19/00
Filed: 2018-06-14
Abstract: L'invention concerne un système d'apprentissage à longue distance comprenant un studio d'instructions et une ou plusieurs salles de classe situées à distance pour des étudiants. Chacun des aspects relatifs à la participation de l'étudiant, les performances académiques et l'utilisation des ressources numériques pour une classe est évalué en temps réel et une couleur lui est attribuée, de sorte que l'enseignant peut facilement évaluer les progrès de chaque étudiant dans la classe lorsqu'il est présenté à l'enseignant dans un affichage qui est uniquement destinée à l'enseignant.
Patent CA-3061864-A1 (CA)
Title: Type i and type iii interferon fusion molecules and methods for use thereof
Inventor: KOTENKO SERGEI V
IPC: A61K38/21
Filed: 2018-05-01
Abstract: Fusion molecules composed of a type I interferon protein or portion thereof and a type III interferon protein or portion thereof, pharmaceutical compositions containing the fusion molecules, and methods for their use in inhibiting infection, inhibiting or treating cancer, inducing signaling of transcription of IFN-stimulated genes through an IFN-.alpha.R2 chain in a sub-ject suffering from an infection which degrades or downregulates an IFN-.alpha.R1 chain, and treating various diseases or conditions are provided.
Patent CA-3062006-A1 (CA)
Title: Foldable aircraft wings
Inventor: DEES PAUL W
IPC: F16C11/04
Filed: 2019-11-18
Abstract: Foldable aircraft wings are disclosed. An example aircraft includes a foldable wing having a fixed wing portion, a foldable wing portion and a hinge to pivotally couple the foldable wing portion relative to the fixed wing portion. The hinge includes a wing transition portion including wing hinge ribs and wing stub ribs, respective ones of the wing hinge ribs coupled to corresponding respective ones of the wing stub ribs. The hinge also includes a tip transition portion including tip hinge ribs, where respective ends of the tip hinge ribs positioned between corresponding respective ones of the wing hinge ribs and the wing stub ribs.
Patent CA-3063765-A1 (CA)
Title: Low profile transcatheter heart valve
Inventor: HARITON ILIA
IPC: A61M25/10
Filed: 2009-06-08
Abstract: An implantable prosthetic valve (10), according to one embodiment, comprises a frame (12), a leaflet structure (14), and a skirt member (16). The frame can have a plurality of axial struts (20) interconnected by a plurality of circumferential struts (22, 24). The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
Patent CA-3066715-A1 (CA)
Inventor: REMAUT HAN
IPC: C07K14/245
Filed: 2018-07-02
Abstract: La présente invention concerne de nouveaux pores protéiques et leurs utilisations dans la détection et la caractérisation d'analytes. L'invention concerne en particulier un complexe poreux isolé formé par un pore de type CsgG et un peptide CsgF modifié, ou un homologue ou un mutant de celui-ci, ce qui permet d'incorporer une constriction de canal supplémentaire ou une tête de lecture dans le nanopore. L'invention concerne en outre un complexe de pores transmembranaires et des procédés de production du complexe de pores, destiné à être utilisé dans des applications de détection moléculaire et de séquençage d'acides nucléiques.
Patent CA-3068587-A1 (CA)
Inventor: MARTNER ANNA
IPC: A61K31/417
Filed: 2018-06-28
Abstract: L'invention concerne des méthodes de retardement et de prévention de rechute de la leucémie aiguë myéloïde (AML) chez des patients présentant une nucléophosmine 1 mutante (NPM1) par co-administration d'histamine, ou de dérivés de celle-ci, et d'interleukine-2 (IL-2). Dans certains modes de réalisation, un retard inattendu dans la rechute et/ou la prévention de celle-ci se traduit par une augmentation surprenante du taux de survie sans leucémie et du taux de survie global.
Patent CA-3069029-A1 (CA)
Title: Aftertreatment arrangement and method for the aftertreatment of at least gases downstream of a fluidized bed gasification as well as logic unit and use
Inventor: ABRAHAM RALF
IPC: C10J3/54
Filed: 2018-06-08
Abstract: The invention relates to an aftertreatment arrangement (10) for the aftertreatment of at least gases downstream of a fluidized bed gasification process, in particular downstream of an HTW gasifier (1) of a pressure-loaded fluidized bed gasification process, having a particle separation unit (2; 11) which can be arranged downstream of the fluidized bed gasification process and upstream of a gas cooler (3) that can be used for the further aftertreatment of the gases, wherein the aftertreatment arrangement comprises an intermediate cooling unit (12) which can be arranged downstream of the fluidized bed gasification process and upstream of the particle separation unit (11), having a return (81) for gasification steam (B) that can be coupled to the fluidized bed gasification process.  Furthermore, the invention relates to a method for the aftertreatment of at least gases downstream of a fluidized bed gasification process as well as the use of an intermediate cooling unit.
Patent CA-3069209-A1 (CA)
Title: System and method for tree-based machine learning
Inventor: XIAO CHENJUN
IPC: G06N20/00
Filed: 2020-01-23
Abstract: Systems and methods of updating a multi-level data structure for controlling an agent. The method may include: accessing a data structure defining one or more nodes. A non-leaf node of the one or more nodes may be associated with one or more edges for traversing to a subsequent node. An edge of the one or more edges may be associated with a visit count and a softmax state-action value estimation. The method may include identifying a node trajectory including a series of nodes based on an asymptotically converging sampling policy, where the node trajectory includes a root node and a leaf node of the data structure, determining a reward indication associated with the node trajectory; and for at least one non-leaf node, updating the visit count and the softmax state-action value estimate associated with one or more edges of the non-leaf node based on the determined reward indication.
Patent CA-3069607-A1 (CA)
Title: Coating and layer system, and bipolar plate, fuel cell and electrolyser
Inventor: DOBRENIZKI LADISLAUS
IPC: C23C14/06
Filed: 2018-06-11
Abstract: The invention relates to a coating (3a), in particular for a bipolar plate (1) of a fuel cell or an electrolyser, the coating (3a) consisting of a homogeneous or heterogeneous solid metal solution.  According to the invention, the coating (3a) comprises either a first chemical element from the group of precious metals in the form of iridium in a concentration of at least 99 atomic % or a first chemical element from the group of precious metals in the form of iridium and a second chemical element from the group of precious metals in the form of ruthenium, the first chemical element and the second chemical element being present overall in a concentration of at least 99 atomic %, and also at least one further non-metallic chemical element from the group comprising nitrogen, carbon, fluorine, wherein oxygen and/or hydrogen are still optionally present only in traces.  The invention further relates to a layer system (3), a bipolar plate (1) having such a layer system (3), a fuel cell and an electrolyser.
Patent CA-3069716-A1 (CA)
Title: Drug delivery device with vacuum assisted securement and/or feedback
Inventor: MCCULLOUGH ADAM B
IPC: A61M37/00
Filed: 2016-02-17
Abstract: A drug delivery device includes a housing having a rigid base with a surface defining at least one pressure communication channel or aperture, which distributes a negative fluid pressure across the base that draws the tissue against the base. The device may further include a porous, adhesive layer disposed over the pressure communication channel(s) or aperture(s), for adhesively attaching the device to tissue, which distribute a negative fluid pressure across the adhesive layer, to draw the tissue against the adhesive layer. The device may further include a pressure sensor for determining whether the device is properly attached to the body tissue by the adhesive layer. Further, at least one bladder may be used instead of the porous, adhesive layer for adhesively attaching the device to tissue. The bladder, in a partially inflated or expanded state, can apply constant pressure across the contact surface as it conforms to the contour of the tissue when the device is applied to the tissue thereby causing a flexible adhesive layer attached to the bottom thereof to conform to the contour of the tissue and adhere thereto. The subsequent evacuation of the bladder causes it to deflate and collapse or retract against the base, thereby causing the flexible adhesive layer, which is adhered to the tissue, to pull the tissue toward the base, thereby stretching the tissue.
Patent CA-3070112-A1 (CA)
Title: Inhibitors of rho associated coiled-coil containing protein kinase
Inventor: SKUCAS EDUARDAS
IPC: A61P9/00
Filed: 2018-07-23
Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
Patent CA-3070185-A1 (CA)
Title: Portable x-ray device and system
Inventor: DIAZ CARMENA ANGEL
IPC: A61B6/00
Filed: 2018-07-12
Abstract: The present invention provides a portable x-ray device with a housing having a side and rear handle, each with triggers and indicator lights in locations suitable for manipulation for use. A trigger is located at each end of each handle and deposed at an angle to be actuated by an operator, with the triggers on one handle controlling a function of the device and the triggers of the other handle controlling a different function. The invention also provides a system including a device with a processor and a wireless device for communication with an external processor.
Patent CA-3071734-A1 (CA)
Title: Direct fire small ceiling speaker system
Inventor: IVEY JOHNATHAN
IPC: H04R1/34
Filed: 2018-09-19
Abstract: An attachment to a small ceiling speaker system that is interchangeable with a diffuser of such system and that provides direct downward direction to sound produced by such system. A director interface is provided for adjustably attaching to an acoustic channel shell of such system. A direct fire ring releasably attaches to the director interface with a fastener. The direct fire ring supports magnets for releasably attaching a foraminous audio speaker grill. The director interface and the direct fire ring have alignable hub and spoke features and the hub and spokes of the director interface partially nest within the hub and spokes of the direct fire ring.
Patent CA-3072047-A1 (CA)
Title: Enceinte de chimie solide avec verrou de securite pour des applications de distribution
Inventor: SCHWARTZ DANIEL RONALD
IPC: B01F1/00
Filed: 2018-08-10
Abstract: L'invention concerne un procédé et un appareil pour obtenir une substance chimique à partir d'un bloc coulissant de matière caustique. Le produit est logé à l'intérieur d'une capsule (110) qui est positionnée dans un distributeur à écoulement turbulent (10) qui utilise un fluide pour éroder le bloc et produire une solution concentrée. Les caractéristiques du fluide peuvent être ajustées sur le terrain pour obtenir un taux de concentration prédéterminé de la solution. La capsule (110) fournit un moyen sûr et pratique pour manipuler, stocker et expédier le bloc caustique sans exposer l'opérateur ou le manipulateur au matériau dangereux. La capsule (110) comprend des composants emboîtés (114, 116) qui peuvent tourner entre une position fermée ou scellée et une position d'utilisation ouverte.
Patent CA-3072656-A1 (CA)
Title: Systems and methods for allocating service requests
Inventor: FU JINQIANG
IPC: G06N20/00
Filed: 2018-06-15
Abstract: The present disclosure relates to systems and methods for providing Onlin-to-Offline services. The method may include obtain first information associated with a first service request having been allocated to a service provider and having been accepted by the service provider. The method may also include obtaining second information associated with a second service request initiated via an application executed by a second requester terminal. The method may also include determining a matching parameter based on the first information and the second information by using at least one trained matching model and determining whether the matching parameter is larger than a threshold. The method may also include transmitting data associated with the second service request based on a result of the determination that the matching parameter is larger than the threshold.
Patent CA-3074070-A1 (CA)
Title: Production de biocarburants, de produits biochimiques et d'une biomasse microbienne a partir de pate cellulosique
Inventor: NARENDRANATH NEELAKANTAM
IPC: C12G3/02
Filed: 2018-08-28
Abstract: L'invention concerne des procédés de production d'alcool, de biomolécules et/ou d'une biomasse microbienne à l'aide d'une charge de pâte cellulosique. La pâte cellulosique est mise en contact avec une composition enzymatique pour produire des sucres fermentescibles, qui sont utilisés comme source de carbone pour un micro-organisme dans le but de produire des alcools ou des produits biochimiques par fermentation et/ou pour produire uniquement une biomasse microbienne.
Patent CA-3078575-A1 (CA)
Inventor: MARBLER HANNES
IPC: F41H7/02
Filed: 2018-09-28
Abstract: In order to produce an electrical device (1) for connection to a high-voltage electrical system comprising a fluid-tight tank (22, 23) which is filled with an insulating fluid, an active element which is arranged in the tank (22, 23) and has a magnetizable core and at least one winding which surrounds a core section, and a bullet-resistant armour (2) which sheaths the tank (22, 23) and forms a mounting opening, which electrical device allows easy access, which can be matched to the respective requirements, for servicing and mounting purposes, it is proposed that the mounting opening can be closed by means of a bullet-resistant cover (8) which can be displaced parallel to the armour (2).
Patent CA-3079500-A1 (CA)
Title: Pluripotent stem cells inducing osteochondral repair
Inventor: KAMEI NAOSUKE
IPC: A61K35/545
Filed: 2018-10-17
Abstract: Multilineage-differentiating stress enduring (Muse) cells are stage-specific embryonic antigen-3 (SSEA-3) positive cells that exist in mesenchymal stem cell (MSC) populations. Muse cells have the pluripotency to differentiate into all germ layers as embryonic stem cells. The purpose of the present study is to investigate the efficacy of Muse cell transplantation for repairing osteochondral defects. Muse cells were isolated from human bone marrow MSCs. As osteochondral defects, the patellar grooves of immunodeficient rats were injured. Next, cells were injected into the mice so that the animals were divided into the following 3 groups: a control group to which PBS was injected; a non-Muse group to which 5x104 SSEA-3 negative non-Muse cells were injected; and a Muse group to which 5x104 SSEA-3 positive Muse cells were injected. In the Muse group, repaired tissues with almost smooth and homogenous surface were observed 12 weeks after the treatment, while no repaired tissue was found in the control and non-Muse groups. Histological evaluation indicates that the Muse group showed better repair in the osteochondral defect sites 4 and 12 weeks after the treatment, compared to the other groups. Thus, Muse cells are likely a novel promising cell source for treating osteochondral defects.
Patent CA-3079853-A1 (CA)
Title: Agricultural header with flexible joint
Inventor: WHITE MATTHEW
IPC: A01D41/06
Filed: 2020-04-30
Abstract: An agricultural header for use with an agricultural harvester is configured to cut crop when the agricultural harvester moves in a direction of travel. The agricultural header comprises a first frame, a side draper belt supported by the first frame and positioned to receive cut crop and advance cut crop laterally relative to the direction of travel, a second frame, a center draper belt supported by the second frame and positioned in register with the side draper belt to receive cut crop laterally therefrom and advance cut crop rearwardly toward the agricultural harvester opposite to the direction of travel, and a joint interconnecting the first frame and the second frame and enabling relative fore-aft and lateral translation between the first frame and the second frame.
Patent CA-3080774-A1 (CA)
Title: System and method for purging a fuel manifold of a gas turbine engine using a flow divider assembly
Inventor: SAINTIGNAN CEDRIC
IPC: F02C9/42
Filed: 2020-05-13
Abstract: Methods and systems of operating a gas turbine engine in a low-power condition are provided. In one embodiment, the method includes supplying fuel to the combustor by supplying fuel to the first fuel manifold via a first flow divider valve and supplying fuel to the second fuel manifold via a second flow divider valve. While supplying fuel to the combustor by supplying fuel to the first fuel manifold, the method includes stopping supplying fuel to the second fuel manifold and supplying pressurized gas to the second fuel manifold via the second flow divider valve to flush fuel in the second fuel manifold into the combustor and hinder coking in the second fuel manifold and associated nozzles.
Patent CA-3081144-A1 (CA)
Inventor: DE HAARD JOHANNES
IPC: C07K16/00
Filed: 2018-12-07
Abstract: Provided are novel methods of treating generalized myasthenia gravis in a subject. These methods generally comprise administering to the subject an effective amount of an isolated FcRn antagonist. In certain embodiments the FcRn antagonist binds to FcRn with increased affinity and reduced pH dependence relative to native Fc region.
Patent CA-3081180-A1 (CA)
Inventor: STEVENSON DAVID GRANVILLE
IPC: A61L27/34
Filed: 2018-10-31
Abstract: A method of manufacturing a tubular graft may include the steps of: providing a textile comprising a tubular wall disposed between a first open end and an opposed second open end, an inner surface and an opposed outer surface defining an interior wall portion therein between, the tubular wall including a textile construction of one or more filaments or yarns, the textile construction by itself being permeable to liquid; applying a substantially water-soluble material to at least a portion of the tubular wall; and applying a substantially water-insoluble sealant to at least a part of the outer surface of the tubular wall, the substantially water-insoluble sealant being configured to mitigate movement of fluid through the wall of the conduit; where the water-soluble material is configured to mitigate penetration of the sealant to the inner surface of the conduit.