baber/WOPTO huggingface dataset:
Patent EP-2857506-A2 (EP)
Inventor: BUJNICKI JANUSZ MAREK
IPC: C12N9/22
Filed: 2012-06-07
Abstract: The present invention relates to the of determining the sequence preference of DNA-RNA hybrid binding protein or its domain which comprises the following steps: 
a) contacting of the purified protein or its domain, with a mixture of a library of DNA-RNA hybrids substrates, wherein DNA-RNA hybrid substrates comprise randomized sequences in the central part, preferably randomized in 9 or 10 nucleotide positions, with flanking sequences fixed and allowing a tested protein or its domain to bind the sequence to which it has an affinity; 
b) separating unbound DNA-RNA hybrids by immobilization of protein or its domain, with bound DNA-RNA hybrid, to the resin, preferably glutathione agarose; 
c) removing the unbound hybrids; 
d) isolating the recombinant protein, together with the associated DNA-RNA hybrids, 
e) amplification of the isolated hybrid using PCR, preferably RT-PCR, wherein in the amplification reaction the primers complementary to invariant sequences flanking the randomized region are used, and wherein during the PCR reaction on one of the primer the sequence of RNA polymerase promoter is added in order to obtain double-stranded DNA for  in vitro  transcription with RNA polymerase; 
f) reverse transcription using reverse transcriptase that does not possess the RNase H activity and a DNA primer complementary to the 3' end of the RNA template in order to obtain a DNA-RNA hybrid..
Patent EP-2799180-A2 (EP)
Title: Verfahren und Vorrichtung zur Oberflächenstrukturierung eines Maschinenelementes
Inventor: WIETHOP MARCO
IPC: B23K26/386
Filed: 2014-04-15
Abstract: Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Durchführung eines Laserbearbeitungsverfahrens zum Einbringen von Ausnehmungen im Bereich einer Kontaktfläche relativ beweglicher Maschinenelemente. Diese als Mikrostrukturierungen dienenden Ausnehmungen bilden anschließend einen optimalen Haftgrund für eine Beschichtung. Um einen von einem Laserbearbeitungskopf der Vorrichtung (9) emittierten Laserstrahl (4) mit der gewünschten hohen Vorschubgeschwindigkeit von mehr als 5 m/s bewegen zu können, ist ein den Laserstrahl (4) ablenkendes Reflektorelement (10) innerhalb eines Schutzrohres (11) angeordnet, sodass der Laserbearbeitungskopf ebenso wie eine nicht dargestellte Werkstückaufspannung für das Maschinenelement während der Bearbeitung unbeweglich ausgeführt sein können. Dabei ist das Reflektorelement (10) gemeinsam mit dem Schutzrohr (11) rotationsbeweglich um die zu dem Laserstrahl (4) koaxiale Drehachse (12) antreibbar. Der Laserstrahl (4) wird zunächst stirnseitig in das Innere des Schutzrohres (11) eingekoppelt und an dem Reflektorelement (10) um ca. 90° so abgelenkt, dass der Laserstrahl (4) durch eine Durchtrittsöffnung (13) aus dem Schutzrohr (11) austritt und auf die Zylinderinnenwandfläche (5) trifft. Darüber hinaus ist das Schutzrohr (11) aber auch vertikal in Richtung der Z-Achse beweglich angeordnet, sodass nahezu alle Bereiche der Zylinderinnenwandfläche (5) problemlos erreicht werden können. Aufgrund der Rotationsbewegung kann eine hohe Vorschubgeschwindigkeit des Laserstrahles (4) auf der Zylinderinnenwandfläche (5) realisiert werden.
Patent EP-2989287-A2 (EP)
Inventor: PTAK KEITH R
IPC: E21B19/00
Filed: 2014-04-23
Abstract: This invention relates to an undersea riser bearing designed to operate at higher temperatures over an extended timeframe while maintaining performance advantages of high capacity laminate (HCL) elastomeric composite bearings.
Patent EP-2970775-A2 (EP)
Inventor: BECK TAYLOR
IPC: B01J23/14
Filed: 2014-03-14
Abstract: Methods, catalysts, and reactor systems for producing in high yield aromatic chemicals and liquid fuels from a mixture of oxygenates comprising di- and polyoxygenates are disclosed. Also disclosed are methods, catalysts, and reactor systems for producing aromatic chemicals and liquid fuels from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like; and methods, catalysts, and reactor systems for producing the mixture of oxygenates from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like. The disclosed catalysts for preparing the mixture of oxygenates comprise a Group VIII metal and a crystalline alumina support.
Patent EP-2968503-A2 (EP)
Inventor: WESTERMAN MARK
IPC: C07K16/26
Filed: 2014-03-13
Abstract: The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies which bind hepcidin and regulate iron homeostasis. Another aspect relates to the use of humanized antibodies which bind hepcidin for the treatment of a disease or condition associated with hepcidin.
Patent EP-3025527-A2 (EP)
Inventor: CHATTERJEE SHUVO
IPC: G06Q30/02
Filed: 2014-07-17
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating geofences. One of the methods includes receiving, at a mobile device, a signal emitted by a merchant device associated with a merchant. If the signal is emitted by a merchant device associated with a merchant and the distance between the mobile device and the merchant device satisfies a threshold, a notification is provided on the mobile device indicating proximity of the merchant associated with the merchant device.
Patent EP-2918861-A2 (EP)
Inventor: QIU LIANGHENG
IPC: F16C33/66
Filed: 2015-01-06
Abstract: A bearing system (30) may have an inner race (32) coupled to an outer race (31) defining a lubrication volume (37) and a shield coupled to the outer race, the shield at least partially defining an aperture (36) of the lubrication volume. The apertu may permit the flow of lubricating oil through the bearing system. The shield may retain a quantity of oil within the bearing system. The bearing system may be operated without an oil supply, for example, during an emergency, and the retained quantity of oil may provide ongoing lubrication.
Patent EP-2910406-A2 (EP)
Inventor: JIN HO SANG
IPC: B60L11/18
Filed: 2015-01-21
Abstract: Disclosed is a charging control device for use in an electric vehicle to control an internal charging device of the electric vehicle. An auxiliary battery supplies DC power. A power supply device change a level of a voltage of the DC power to supply power. A power supply control device controls the supply of the DC power to the power supply device. A power supply device control signal generation unit transmits a charging start signal to the power supply control device in the case where a charging start condition is satisfied.
Patent EP-3015582-A2 (EP)
Inventor: FOSS STEPHEN W
IPC: D04H1/55
Filed: 2015-04-01
Abstract: Described are fibrous products for molding for use in Automotive products such as Underbody Aero-shields, wheel house liners, and Engine compartment applications with enhanced heat aging capability, abrasion resistance, and resistance to water, oils, and other fluids and is recyclable. The fibrous products also have acoustical benefits such as improved acoustical impedance or sound dampening properties over currently available acoustic insulation materials.
Patent EP-2937950-A2 (EP)
Inventor: KONDO TAKAHIRO
IPC: H01R12/71
Filed: 2015-04-17
Abstract: A connector includes a ground pin and a signal pin. The ground pin includes a first cylindrical part, a first cylindrical terminal telescopically movable into the first cylindrical part, and a first elastic member compressible in a first central axis direction. The signal pin includes a second cylindrical part, a second cylindrical terminal telescopically movable into the second cylindrical part, and a second elastic member compressible in a second central axis direction. 
     The signal pin is provided concentrically with the first elastic member and the first cylindrical part, and has a one-piece structure of a single metal plate. The first and the second cylindrical parts are connected to a ground line and a signal line of a board with the first and second cylindrical terminals being in contact with the board and compressed in the first and second central axis directions, respectively.
Patent EP-2980780-A2 (EP)
Inventor: PARK SUNGJAE
IPC: G09G3/20
Filed: 2015-07-17
Abstract: A display apparatus includes a display panel, a timing controller, a gate driver, and a data driver. The display panel includes a plurality of pixel groups. Each of the pixel groups includes a first pixel and a second pixel disposed adjacent to the first pixel. The first and second pixels together include n (n is an odd number equal to or greater than 3) sub-pixels. The first and second pixels share their collective {(n+1)/2}th sub-pixel.
Patent EP-2995181-A2 (EP)
Inventor: KOMATSU SHIGERU
IPC: A01B63/10
Filed: 2015-07-17
Abstract: A lift control apparatus includes a height sensor that outputs a height detection signal after a height of a ground work apparatus is detected. The ground work apparatus is coupled to a traveling work vehicle via a lift mechanism. An upper limit manager sets an upper limit position of the ground work apparatus based on an operation input signal from an input operation device for an upper limit setting USD. A setting prohibitor prohibits, when the upper limit position being set by the operation input signal is lower than the height of the ground work apparatus based on the height detection signal, the setting of the upper limit position from the operation input signal, and setting the upper limit position to the height of the ground work apparatus based on the height detection signal.
Patent EP-3119423-A2 (EP)
Inventor: LOEW ANDREAS
IPC: C07K14/725
Filed: 2015-03-13
Abstract: The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein.
Patent EP-3149479-A2 (EP)
Inventor: CORTES-GARCIA GUADALUPE
IPC: G01N33/569
Filed: 2015-05-29
Abstract: The present invention provides, among other things, compositions and methods for analyzing the expression and conformation of engineered influenza hemagglutinin. In particular, the present invention provides methods of screening in silico designed HA antigens using neutralizing antibody panels specific to conserved epitopes. In some embodiments, the HAs are down selected for inclusion in universal influenza vaccines based upon their binding to neutralizing antibody panels in immunostaining assays.
Patent EP-3193916-A2 (EP)
Inventor: GALLOU CATHERINE
IPC: A61K39/00
Filed: 2015-07-17
Abstract: L'invention se rapporte à un polypeptide chimère optimisé destiné à être utilisé chez des patients atteint de cancer à HLA-337, qui comprend quatre peptides optimisés dérivés d'épitopes tumoraux cryptiques (CEA, TERT, MAGE et HER -2/neu) pour accroître leur immunogémicité.
Patent EP-3198628-A2 (EP)
Inventor: CHAMPENOIS CAROLINE ANTOINETTE MADELEINE
IPC: G01N21/64
Filed: 2015-09-25
Abstract: Un aspect de l'invention concerne un procédé non destructif (1) de détection de particules chargées comprenant les étapes consistant à : - mesurer (st00) une valeur de référence d'au moins un paramètre physique d'un nuage d'ions confiné dans un piège à ions; - exécuter (st10) une injection d'un échantillon dans le nuage d'ions confiné dans le piège à ions, l'échantillon traversant le nuage d'ions et sortant du nuage d'ions sans être emprisonné à l'intérieur du piège à ions; - mesurer (st20) une première valeur expérimentale dudit au moins un paramètre physique du nuage d'ions; - comparer (st30) la première valeur expérimentale à la valeur de référence afin de déterminer la présence d'au moins une particule chargée dans l'échantillon, ou l'absence de toute particule chargée dans l'échantillon.
Patent EP-3192519-A2 (EP)
Inventor: CHOI SEUNG-HYON
IPC: A61K36/66
Filed: 2015-06-02
Abstract: The present invention provides an antiseptic and antibiotic composition containing a  Pseudomonas aeruginosa  culture solution extract as an active ingredient. The present invention provides a composition for preventing or treating acne, containing a  Pseudomonas aeruginosa  culture solution extract as an active ingredient. The composition containing a  Pseudomonas aeruginosa  culture solution extract, of the present invention, exhibits a broad antibiotic spectrum and a high antioxidant effect against various bacteria, and the composition can be applied to a cosmetic composition such as a cosmetic product and can also be useful for antibiotic, sterilizing and antiseptic purposes in various fields such as food, medical supplies, agricultural chemicals and household items. The present invention identifies a specific active ingredient causing the antibiotic effect of a  Pseudomonas aeruginosa  culture solution extract, and provides the structure thereof.
Patent EP-3181954-A2 (EP)
Inventor: BOSTON JAMES
IPC: F16H61/14
Filed: 2016-11-21
Abstract: A hydraulic circuit (160) supplies pressurized hydraulic fluid to and from a torque converter (130) that is operatively associated with a lockup clutch (132). The torque converter (130) is disposed upstream of an outlet regulator (192) that maintains a predetermined pressure in the torque converter (130). Power transmission in a powertrain (122) can be directed through the torque converter (130) during a hydrodynamic mode and can be directed through the lockup clutch (132) during lockup mode. To switch between the hydrodynamic mode and the lockup mode, the hydraulic circuit (160) includes a diverter valve (180) to selectively direct pressurized hydraulic fluid between the torque converter (130) and the lockup clutch (132). When operating in the lockup mode, the diverter valve (180) further diverts hydraulic fluid discharged for the torque converter (130) to bypass the outlet regulator (192) disposed downstream of the torque converter (130).
Patent EP-3344803-A2 (EP)
Inventor: LIM WENDELL A
IPC: C07K14/705
Filed: 2016-08-31
Abstract: La présente invention concerne des bibliothèques de polypeptides modulaires synthétiques et des acides nucléiques codant pour de telles bibliothèques de polypeptides modulaires synthétiques. L'invention concerne également des procédés de préparation de bibliothèques de polypeptides modulaires synthétiques et des acides nucléiques codant pour de telles bibliothèques de polypeptides modulaires synthétiques. L'invention concerne également des procédés de criblage d'une bibliothèque de polypeptides modulaires synthétiques pour identifier un phénotype sélectionné associé à un élément d'une bibliothèque de polypeptides modulaires synthétiques, de tels procédés servant dans des dosages à la fois in vitro et in vivo.
Patent EP-3205287-A2 (EP)
Inventor: MARTINEZ MICHELLE D
IPC: A61B17/29
Filed: 2011-10-11
Abstract: The medical device for engaging tissue comprises a housing (42) defining an internal passageway and a longitudinal axis extending between proximal and distal ends of the housing, a first jaw (44) rotatable relative to the housing, the first jaw (44) having proximal and distal ends, and a second jaw (46) rotatable relative to the housing, the second jaw (46) having proximal and distal ends. A driver (148) is engaged with the proximal ends of the first and second jaws, and longitudinal movement of the driver rotates the first and second jaws relative to the housing. A biasing strip (190) is operatively connected to at least one of the first and second jaws to bias the jaws radially, wherein a middle portion of the biasing strip (190) is fixed to a distal end (166) of the driver and moves therewith. An elongated drive wire (22) is selectively connected to the driver for longitudinal movement therewith.
Patent EP-3485545-A2 (EP)
Title: Laserpulsgenerator und verfahren zur erzeugung eines laserpulses
Inventor: FLAIG RAINER
IPC: H01S3/10
Filed: 2017-07-12
Abstract: Ein Laserpulsgenerator (100, 200) mit a. einer Pulsformgenerierungseinrichtung (2), aufweisend i. einen Pulsformspeicher (3) zur Speicherung von Daten und einen damit verbundenen Digital-Analog-Wandler (DAC) (4), ii. einen ersten Anschluss (5) zum Anschluss einer Startsignalleitung (6) eines Startsignalpfads (7), iii. einen zweiten Anschluss (8) zum Anschluss einer Taktsignalleitung (9), iv. einen dritten Anschluss (11) zum Anschluss einer Pulsleitung (12), wobei der erste und zweite Anschluss (5, 8) so mit dem Pulsformspeicher (3) und dem DAC (4) verbunden sind, dass bei einem vorgegebenen Startsignal Daten vom Pulsformspeicher (3) zum DAC (4) geleitet und vom DAC (4), insbesondere im Takt eines Taktsignals, in einen Ausgangspuls gewandelt wird, der am dritten Anschluss (11) zur Ansteuerung eines Treibers (13) für eine Laserdiode (14) bereitgestellt wird, b. eine Takteinheit (10), die mit dem zweiten Anschluss (8) über die Taktsignalleitung (9) verbunden ist, ist dadurch gekennzeichnet, dass c. die Takteinheit (10) einen Rücksetzanschluss (105) aufweist, der mit dem Startsignalpfad (7) verbunden ist.
Patent EP-3503924-A2 (EP)
Title: Polypeptides bcl-w et mimétiques pour traiter ou prévenir une neuropathie périphérique induite par une chimiothérapie et une perte d'audition
Inventor: SEGAL ROSALIND
IPC: C07K14/47
Filed: 2017-08-25
Abstract: L'invention concerne des compositions et des méthodes pour le traitement ou la prévention d'une neuropathie périphérique induite par une chimiothérapie et une perte d'audition chez un sujet en ayant besoin. Les méthodes consistent à administrer au sujet une protéine bclw, un fragment de celle-ci contenant un domaine BH4, ou un mimétique de bclw. L'invention concerne également des mimétiques de bclw donnés à titre d'exemple.
Patent EP-3526325-A2 (EP)
Inventor: JERALA ROMAN
IPC: C07K19/00
Filed: 2017-09-27
Abstract: Invention refers to combination of split orthogonal proteases that recognize and cleave target sequence of at least 6 amino acids. Parts of split orthogonal proteases are fused to dimerization domains that allow formation of the whole protease from two split protease parts. At least two orthogonal proteases are designed as split fragments fused to dimerization domains where dimerization can be induced with either light, chemicals or other input signal. Proteases cleave one or more target proteins that include cleavage site for one or more orthogonal proteases and act as a signal transducers, reporters or therapeutic proteins. With appropriately selected target proteins, logical circuits mediated by proteases can be prepared. The invention also relates to cells that contain expressed split proteases to transmit the signal.
Patent EP-3592359-A2 (EP)
Inventor: GALVIN GABRIEL M
IPC: A61K31/575
Filed: 2018-03-07
Abstract: The crystalline forms of obeticholic acid and methods of preparation and use thereof are described.
Patent EP-3631253-A2 (EP)
Inventor: TÜTEK SERDAR
IPC: F16J15/32
Filed: 2018-05-17
Abstract: The stationary gasket used in all kinds of dishwashers and similar household appliances, characterized in that; it ensures the sealing not by being compressed but by stretching and ensures sealing in both ways with a single part.
Patent EP-3711110-A2 (EP)
Inventor: BUSACCA ROBERT S
IPC: H01M50/54
Filed: 2018-11-15
Abstract: Secondary batteries and methods of manufacture thereof are provided. A secondary battery can comprise an offset between electrode and counter-electrode layers in a unit cell. Secondary batteries can be prepared by removing a population of negative electrode subunits from a negative electrode sheet, the negative electrode sheet comprising a negative electrode sheet edge margin and at least one negative electrode sheet weakened region that is internal to the negative electrode sheet edge margin, removing a population of separator layer subunits from a separator sheet, and removing a population of positive electrode subunits from a positive electrode sheet, the positive electrode sheet comprising a positive electrode edge margin and at least one positive electrode sheet weakened region that is internal to the positive electrode sheet edge margin, and stacking members of the negative electrode subunit population, the separator layer subunit population and the positive electrode subunit population.
Patent EP-3549887-A2 (EP)
Inventor: Brouk Justin
IPC: B65G13/071
Filed: 2019-04-02
Abstract: The present disclosure relates to a conveyor cartridge removably coupled with a first side plate and an opposite second side plate that delimit a direction of the conveyor cartridge transverse to transport direction. Conveyor rollers rotatably mounted to axles and extending a conveyor roller width between the first side plate and the second side plate. Braking mechanism positioned internally in the cartridge frame in between the first side plate and the opposite second side plate. The braking mechanism abuts the conveyor rollers to retard rotation of the conveyor rollers.
Patent EP-3588086-A2 (EP)
Inventor: REYNOLDS JEFFREY S
IPC: G01N33/487
Filed: 2013-03-13
Abstract: A replaceable sensor cartridge (100) comprises a frame having a desiccant material (108) and a chamber for accepting a plurality of biosensors (102); a strip picker configured to deploy a top biosensor (412a) from the plurality of biosensors, the strip picker including a flexible pawl (1126) for providing a ratchet action along the top portion (410) of the frame; and an anti-jamming feature including a deflecting portion (1202) attached to a hinge (1204) on the replaceable sensor cartridge and configured to rotate about the hinge to open and provide access to an interior of the replaceable sensor cartridge, the deflecting portion configured to create a temporary allowance of more than one biosensor to clear a jam in the replaceable sensor cartridge.
Patent EP-3886658-A2 (EP)
Inventor: KNOX DAVIS PURCELL
IPC: A47J37/07
Filed: 2019-11-26
Abstract: A portable grilling system comprising a grate formed of a non-flammable material; at least two support members formed of a non-flammable material and pivotally attached to the grate; at least one fuel insert support member formed of a non-flammable material and positioned below the grate; and a fuel insert comprising a base tray formed of a biodegradable material having a bottom surface and one or more sidewalls extending upwards from the bottom surface; a biodegradable and non-flammable liner positionable within the base tray; and a fuel source positionable within the liner.
Patent EP-3772055-A2 (EP)
Inventor: SEO HAE KWAN
IPC: G09G3/3275
Filed: 2020-07-13
Abstract: A display device includes a display including scan lines, data lines, light emission control lines, and pixels connected thereto, a scan driver configured to sequentially provide scan signals to the scan lines, a data driver configured to provide data signals to the data lines, a light emitting driver configured to provide light emission control signals to the light emission control lines based on a light emission clock signal having pulses, and a timing controller configured to provide the light emission clock signal to the light emitting driver, to output the pulses of the light emission clock signal during a frame in a first mode, to mask at least one pulse of the pulses during a first period of the frame in a second mode, and to output at least another pulse of the pulses during a second period after the first period.