Patent SG-11201805255T-A (SG)
Title: Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
Inventor: YIE JUNMING
IPC: A61P3/10
Filed: 2016-12-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPOIPCT (10) International Publication Number WO 2017/112824 A3 (51) International Patent Classification: C07K16/28 (2006.01) A61K39/395 (2006.01) A61K38/26 (2006.01) A61P3/10 (2006.01) (21) International Application Number: PCT/US2016/068138 (22) International Filing Date: 21 December 2016 (21.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/387,486 23 December 2015 (23.12.2015) US 62/337,799 17 May 2016 (17.05.2016) US 62/420,415 10 November 2016 (10.11.2016) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, M/S 28-2-C, Thousand Oaks, California 91320- 1799 (US). (72) Inventors: YIE, Junming; 4 Sugarwood Way, Warren, New Jersey 07059 (US). SHI, Donghui; 3198 Rickey Court, Thousand Oaks, California 91362 (US). LLOYD, David J.; 458 Via Gregorio, Thousand Oaks, California 91320 (US). WANG, Jinghong; 1540 Escobita Avenue, Palo Alto, California 94306 (US). SIVITS, JR., Glenn N.; 1347 Alessandro Drive, Newbury Park, California 91320 (US). VENIANT-ELLISON, Murielle M.; 645 Camino Manzanas, Thousand Oaks, California 91360 (US). KO- MOROWSKI, Renee; 370 Chapel Drive, Ventura, Cali­ fornia 93003 (US). AGRAWAL, Neeraj; 1610 Camino Olmo, Apt. K, Thousand Oaks, California 91320 (US). BATES, Darren L.; 238 Saint Croix Court, Oak Park, California 91377 (US). CLAVETTE, Brandon C. P.; 3487 Princeton Avenue, Coquitlam, British Columbia V3E 0K5 (CA). FOLTZ, Ian N.; 2108 Knightswood Place, Burnaby, British Columbia V5A 4B9 (CA). HO, Shu-yin; 472 Cosmos Court, Thousand Oaks, California 91360 (US). MURAWSKY, Christopher; 1141 Edmonds Road, Roberts Creek, British Columbia VON 2W0 (CA). MIN, Xiaoshan; 1900 David Drive, Burlingame, California 94010 (US). WANG, Zhulun; 660 Glenbrook Drive, Palo Alto, California 94306 (US). (74) Agent: DERMOTT, Jonathan M.; AMGENT INC., One Amgen Center Drive, Patent Operations, M/S 28-2-C, Thousand Oaks, California 91320-1799 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 10 August 2017 •t CJ oo CJ o CJ (54) Title: METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS (57) : Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR poly­ peptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.