Patent AU-2011378427-B2 (AU)
Title: Lung cancer biomarkers and uses thereof
Inventor: RIEL-MEHAN
IPC: G01N33/574
Filed: 2011-10-24
Granted: 2015-07-16
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/062515 A2 2 May 2013 (02.05.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every G06F 19/10 (2011.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US2011/057499 DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, 24 October 2011 (24.10.2011) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, (26) Publication Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): SOMA LOGIC, INC. [US/US]; 2945 Wilderness Place, Boulder, (84) Designated States (unless otherwise indicated, for every Colorado 80301 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (72) Inventors; and UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, (75) Inventors/Applicants (for US only): RIEL-MEHAN, Mi- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, chael [US/US]; 845 W. Linden St., Louisville, Colorado DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 80027 (US). STEWART, Alex, A.E. [GB/US]; 20 Wyola LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Prospect, Waltham, Massachusetts 02451 (US). OSTRO- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, FF, Rachel, M. [US/US]; 10203 King Court, Westminster, GW, ML, MR, NE, SN, TD, TG). Colorado 80031 (US). WILLIAMS, Stephen, Alaric [GB/US]; 3111 4th Street, Boulder, Colorado 80304 (US). Published: BRODY, Edward, N. [US/US]; 4121 S. Hampton Circle, - without international search report and to be republished Boulder, Colorado 80301 (US). upon receipt of that report (Rule 48.2(g)) (74) Agents: SWANSON & BRATSCHUN, L.L.C. et al.; 8210 SouthPark Terrace, Littleton, CO 80120 (US). If) (54) Title: LUNG CANCER BIOMARKERS AND USES THEREOF If) (57) Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and dia gnosis of non-small cell lung cancer and general cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose non-small cell lung cancer or general cancer. In another aspect, methods are provided for dia gnosing non-small cell lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based f4 on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer in an individual, where the meth ods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomark er selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer, or the likeli hood of the individual having cancer is determined, based on the at least one biomarker value.