baber/WOPTO huggingface dataset:
Patent CA-3067605-A1 (CA)
Title: Chimeric antigen receptors with mutated cd28 costimulatory domains
Inventor: DAVILA MARCO L
IPC: C07H21/04
Filed: 2018-07-06
Abstract: Disclosed herein are chimeric antigen receptor (CAR) polypeptides, which can be used with adoptive cell transfer to target and kill cancers, that comprise a co-stimulatory signaling region having a mutated form of a cytoplasmic domain of CD28 that enhances CAR-T cell function, e.g. by reducing CAR-T cell exhaustion. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a tumor associated antigen-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
Patent CA-3068999-A1 (CA)
Inventor: ZHANG KAI
IPC: F16L3/13
Filed: 2020-01-20
Abstract: The disclosure is directed to a pipe clamp configured to support a pipe from a mounting surface. The pipe clamp includes a mounting post, arm, and hinge. The mounting post has a first post end and a second post end that includes a first coupling element. The mounting post defines a first recess. The arm has a first arm end and a second arm end that includes a second coupling element configured to couple to the first coupling element. The arm defines a second recess. The hinge is positioned between the mounting post and the arm and is connected to the first post end of the mounting post and to the first arm end of the arm.  The mounting post and arm are rotatable about the hinge from an open position to a closed position. In the closed position the first coupling element is coupled to the second coupling element.
Patent CA-3072416-A1 (CA)
Title: Shear press with improved jaws
Inventor: BONFIGLIOLI CESARE
IPC: B30B9/30
Filed: 2018-08-28
Abstract: A shear press (100) for scrap comprising a machine body (105) defining a compaction channel (125) adapted to contain the scrap and guide it in a sliding manner along a predetermined advance direction (A), compaction means (155) and cutting means (180); wherein the compaction means (155) comprise: two mutually opposed jaws (170) articulated to the machine body (105) according to axes of rotation (B) parallel to each other and orthogonal to the advance direction (A) of the scrap, and actuating members (175) adapted to rotate said jaws (170) around the respective axes of rotation (B), in opposite directions, between an open configuration and a closed configuration, thereby reducing the space between the two jaws (170); wherein each jaw (170) comprises an operating surface (400) adapted to laterally de-limit the compaction channel (125) when the jaw (170) is in open configuration; wherein the cross section of said operating surface (400), carried out with respect to a section plane orthogonal to the axis of rotation (B), comprises an end (405) proximal to the axis of rotation (B), an end (410) distal from the axis of rotation (B) and at least one first rectilinear stretch (415) that is parallel to the advance direction (A) of the scrap when the jaw (170) is in the closed configuration, and wherein the extreme point (420) of said first rectilinear stretch (415) with respect to the axis of rotation (B) of the jaw (170) does not coincide with the distal end (410) of the cross section of the operating surface (400) but is aligned to the latter along a direction of alignment (C) which forms, with said first rectilinear stretch (415), an angle (a) having its vertex facing the inner part of the compaction channel (125).
Patent CA-3073555-A1 (CA)
Inventor: LINDBERG PER LENNART
IPC: A61K31/513
Filed: 2018-01-05
Abstract: The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering the diastereomerically pure folate adjuvant [6R]-5,10-methylenetetrahydrofolate in 5-fluorouracil (5-FU) based chemotherapy.
Patent CA-3074424-A1 (CA)
Title: Adhesifs a structure hybride urethane-acrylate
Inventor: CHEN JIANXIA
IPC: C08G18/66
Filed: 2018-08-27
Abstract: L'invention concerne une composition adhésive polymérisable comprenant une composition adhésive polymérisable hybride en deux parties. En particulier, la composition adhésive polymérisable comprend un complexe organoborane-monoamine, un polyol libre comprenant un polyol gras dimère et un polyéther polyol, au moins un composant polymérisable par voie radicalaire, un prépolymère d'uréthane à terminaison isocyanate, un isocyanate libre et un composé d'extension de chaîne de faible poids moléculaire. Des procédés de préparation et d'utilisation d'un adhésif hybride obtenu par polymérisation de la composition adhésive polymérisable selon l'invention sont en outre décrits.
Patent CA-3077297-A1 (CA)
Title: Omni-directional camera with fine-adjustment system for calibration
Inventor: BELANGER-GARNIER VICTOR
IPC: G02B17/00
Filed: 2020-03-27
Abstract: A multi-sensor omnidirectional camera or cameras where the virtual center of projections of the cameras are controlled using movable reflective surfaces. The virtual center of projections can be placed in closer proximity to one another than would otherwise be possible due to physical space limitations. In addition, the reflective surfaces can be controlled in such a way as to offset or compensate for different camera displacements and rotations in order to achieve a configuration where high fidelity to a natural field-of-view is attained. This proves beneficial in virtual reality applications where a high level of visual fidelity is necessary for full immersion.
Patent CA-3079011-A1 (CA)
Inventor: XIE HONGZHI
IPC: C12M1/34
Filed: 2018-10-19
Abstract: L'invention concerne la détection de diméthylarginine symétrique (DMAS). Plus particulièrement, l'invention concerne la détection de DMAS en utilisant une phase solide. L'invention concerne des dispositifs, des réactifs, des kits et des procédés de détection de diméthylarginine symétrique (DMAS) dans un échantillon, tel qu'un échantillon biologique provenant d'un animal. Le procédé comprend la détection de la présence ou de la quantité de DMAS dans l'échantillon en utilisant un format de dosage immunologique, tel qu'un dosage immunologique compétitif. Le dosage comprend l'utilisation d'anticorps contre la DMAS qui sont spécifiques de la DMAS et qui ont moins d'affinité pour d'autres dérivés d'arginine.
Patent CA-3081103-A1 (CA)
Inventor: WHELAN CHRIS
IPC: A61B17/132
Filed: 2018-10-31
Abstract: L'invention concerne un clip conçu pour être utilisé avec une sangle allongée pour former un garrot, comprenant une première et une deuxième partie conçues pour être reliées à la sangle, la première et la deuxième partie étant conçues pour être reliées ensemble de manière détachable pour former une boucle fermée. La deuxième partie est conçue pour être mobile le long de la sangle et présente un passage ouvert à travers lequel passe la sangle. Une première et une deuxième paroi allongées formées d'un seul tenant définissent au moins une partie du passage et une première et une deuxième partie de préhension pour saisir la sangle. La deuxième paroi est montée pour tourner autour d'un axe transversal de façon à déplacer la partie de préhension de la deuxième paroi vers ou à l'opposé de la première partie de préhension.
Patent CA-3081155-A1 (CA)
Title: Systems to monitor characteristics of materials involving optical and acoustic techniques
Inventor: AGOSTINELLI GREGORY A
IPC: A47G23/00
Filed: 2018-11-01
Abstract: An example system for monitoring a characteristic of a material. The system includes a stimulator to provide a stimulus signal to the material. The stimulus signal includes at least one of an electrical signal, a magnetic signal, an optical signal, and an acoustic signal. The system includes a sensor to measure a response signal from the material. The response signal includes at least one of an electrical signal, a magnetic signal, an optical signal, and an acoustic signal. At least one of the stimulus signal and the response signal includes an optical signal or an acoustic signal. The system further includes a controller in communication with the stimulator and the sensor to apply machine learning to determine a characteristic of the material based on the stimulus signal and the response signal, wherein the characteristic is not directly measurable.
Patent CA-3081665-A1 (CA)
Inventor: WEHLIN KARL PETTER
IPC: F16L55/32
Filed: 2018-09-19
Abstract: A robotic apparatus comprising first, second, and third wheel assemblies, and a clamping mechanism configured to apply a force for urging the second wheel and the third wheel to pivot in opposing directions towards a plane of the first wheel for securing the first wheel, the second wheel, and the third wheel to the pipe, each wheel assembly including an alignment mechanism for adjusting an orientation of the wheels to allow the robotic apparatus to move along a straight path or a helical path on the pipe. A method for navigating an obstacle on a pipe comprising advancing the robotic apparatus along a helical pathway on the pipe to position an open side of the robotic apparatus in longitudinal alignment with the obstacle, and advancing the robotic apparatus along a straight pathway on the pipe such that the obstacle passes unobstructed through the open side of the robotic apparatus.
Patent CA-3081859-A1 (CA)
Inventor: YELTON ALEXIS
IPC: G10L15/18
Filed: 2018-06-22
Abstract: A media guidance application may monitor a conversation among users, and identify keywords in the conversation, without the use of wakewords. The keywords are used to search for media content that is relevant to the on-going conversation Accordingly, the media guidance application presents relevant content to the users, during the conversation, to more actively engage the users.  A conversation monitoring window may be used to present conversation information as well as relevant content. A listening mode may be used to manage when the media guidance application processes speech from a conversation The media guidance application may access user profiles for keywords, select content types, select content sources, and determine relevancy of media content, to provide content in context of a conversation.
Patent CA-3085318-A1 (CA)
Title: Peptide immunogens of il-31 and formulations thereof for the treatment and/or prevention of atopic dermatitis
Inventor: WANG CHANG YI
IPC: A61K47/64
Filed: 2018-12-11
Abstract: The present disclosure is directed to individual peptide immunogen constructs targeting portions of the Interleukin-31 (IL-31) protein for the treatment and/or prevention of a pruritic condition and/or an allergic condition, such as atopic dermatitis. The present disclosure is also directed to compositions containing the peptide immunogen constructs, methods of making and using the peptide immunogen constructs, and antibodies produced by the peptide immunogen constructs.
Patent CA-3087106-A1 (CA)
Inventor: ZHANG HONGYAN
IPC: A61K47/50
Filed: 2018-11-29
Abstract: L'invention concerne un composé permettant de former un conjugué avec un agent actif tel qu'un oligonucléotide possédant une structure représentée par la formule (321), et un conjugué correspondant. Le conjugué peut cibler spécifiquement des hépatocytes, ce qui permet de résoudre efficacement les problèmes associés à l'administration de médicaments à base d'oligonucléotides in vivo, et présente une faible toxicité et une excellente efficacité d'administration tout en maintenant une stabilité élevée pour l'oligonucléotide administré. (321)
Patent CA-3087446-A1 (CA)
Inventor: KERANEN OLLI
IPC: A61B17/064
Filed: 2019-01-04
Abstract: A medical fastening device (100) for fastening or coupling an object (400A, 400B) into a tissue (20) have proximal (100A) and distal (100B) portions. It also comprises a helical body structure (107), where the helical body structure comprises a thread or ridge (104) having a lead (105) between said proximal and distal portions. The helical body structure comprises a first portion (101/103) and a second portion (102) next to said first portion (101). The thread of the helical body structure advantageously extends through the first (101) and second (102) portions and the properties, such as a pitch and/or lead, of the thread vary along the longitudinal axis (106) of the helical body structure so that the property of the thread has a first value in the first portion (101) and a second value in the second portion (102) so to provide different compressive force to the object and/or tissue introduced in said first and second portions of the helical body structure, and wherein the first value differs from the second value.
Patent CA-3094655-A1 (CA)
Inventor: ANAND PJ
IPC: A61M39/22
Filed: 2014-01-22
Abstract: ABSTRACT Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system and for opening auxiliary fluid pathways through a shunt system are also disclosed herein. CA 3094655 2020-09-29
Patent CA-3096371-A1 (CA)
Title: Systeme et procede pour la coalescence et la resynchronisation de flux de donnees asynchrones a multiples domaines d'horloge
Inventor: LEE WINSTON
IPC: G06F5/06
Filed: 2019-03-29
Abstract: Une pluralité de FIFO de synchronisation reçoivent des flux de données d'entrée depuis des agents de transmission correspondants. Des données sont écrites dans les FIFO de synchronisation sur la base de signaux d'horloge d'écriture fournis par les agents de transmission correspondants. Un circuit d'arbitrage lit des données dans les FIFO de synchronisation sur la base d'un signal d'horloge locale asynchrone. Un nombre minimal d'entrées (SMIN) de chaque FIFO de synchronisation est spécifié par un nombre d'entrées requises pour synchroniser les données stockées sur le signal d'horloge locale. Le SMIN peut en outre être spécifié par : un nombre d'entrées requises pour stocker des données durant une période de temps seuil durant laquelle un débit des flux de données d'entrée peut dépasser un débit de données lues activé par le signal d'horloge locale ; un nombre d'entrées requises pour stocker les données durant un temps de réponse de commande de flux ; et un nombre d'entrées lues dans le FIFO de synchronisation durant la période de temps seuil et le temps de réponse de commande de flux.
Patent CA-3097041-A1 (CA)
Title: Partie centrale de verrou electromecanique
Inventor: ALLEN BRENDON
IPC: E05B47/02
Filed: 2019-04-12
Abstract: L'invention concerne une partie centrale de verrou électromécanique interchangeable destinée à être utilisée avec un dispositif de verrouillage présentant un état verrouillé et un état déverrouillé. La partie centrale de verrou électromécanique interchangeable peut comprendre une fiche mobile présentant une première position par rapport à un corps de partie centrale de verrou qui correspond au dispositif de verrouillage dans l'état verrouillé, et une seconde position par rapport à un corps de partie centrale de verrou qui correspond au dispositif de verrouillage dans l'état déverrouillé. La partie centrale de verrou électromécanique interchangeable peut comprendre un élément de retenue de partie centrale accouplé mobile à un corps de partie centrale de verrou. L'élément de retenue de partie centrale peut être positionnable dans une position de retenue dans laquelle l'élément de retenue de partie centrale s'étend au-delà d'une enveloppe du corps de partie centrale de verrou pour maintenir le corps de partie centrale de verrou dans une ouverture du dispositif de verrouillage, et une position de retrait dans laquelle l'élément de retenue de partie centrale est rétracté par rapport à la position de retenue pour permettre le retrait.
Patent CA-3097157-A1 (CA)
Title: Capstan-driven air pump system for opening and closing a longitudinal railcar door
Inventor: DEGROOT ROBERT J
IPC: B61D7/28
Filed: 2020-10-27
Abstract: According to some embodiments, an apparatus comprises an air pump configured to couple to a capstan, and a pneumatic cylinder coupled to the air pump at a first end of the pneumatic cylinder. The pneumatic cylinder comprises a piston. Rotation of the capstan in a first rotational direction causes the air pump to provide air pressure to the first end of the pneumatic cylinder. In response to the air pump providing air pressure to the first end of the pneumatic cylinder, the piston of the pneumatic cylinder moves in a first linear direction. The piston is coupled to a longitudinal beam of a longitudinal door system of a railcar. In response to the piston moving in the first linear direction, the longitudinal beam moves in the first linear direction, opening a door of the longitudinal door system.
Patent CA-3098653-A1 (CA)
Title: Fusion proteins composed of an interleukin-2 mutein and type i interferon
Inventor: HERNANDEZ GARCIA TAYS
IPC: C12N15/62
Filed: 2019-05-03
Abstract: The present invention describes fusion proteins based on cytokines, called bi-cytokines (BC), specifically formed by the binding of an IL2 agonist mutein with a type I interferon (IFN), linked by an Fc region of a mutant human IgG 1 and a connector peptide. The combination of an IL2 agonist mutein and a type I IFN in the structure of the resulting molecules gives surprising immunoregulatory properties to these molecules and a superior therapeutic effect than that of parental cytokines, or their combination, which makes them attractive and novel molecules for the treatment of cancer. The invention also relates to pharmaceutical compositions comprising the fusion proteins as an active ingredient.
Patent CA-3103248-A1 (CA)
Title: Fluid delivery valve system and method
Inventor: GABRIEL GEORGE S
IPC: F16K31/00
Filed: 2014-03-17
Abstract: ABSTRACT A cage-mounted fluid delivery system for delivering a fluid from a water source, such as a fluid bag or an automatic water system, to animals housed in cages in high density caging systems may comprise a fluid delivery valve assembly, wherein the fluid delivery valve assembly is adapted to be coupled to the water source to facilitate the provision of fluid to animals housed in the cages. The cage-mounted fluid delivery valve assembly may further comprise a valve body and end cap, which may be joined together, that define a fluid channel. The cage-mounted fluid delivery valve assembly may further comprise sealing elements, a spring element, and an interior stem disposed at least in part in the fluid channel to open and close the fluid channel. 4422410 Date Recue/Date Received 2020-12-18
Patent CA-3110489-A1 (CA)
Title: Aquatic trap
Inventor: BENDURE ERICK
IPC: A01K69/10
Filed: 2021-02-25
Abstract: ABSTRACT  Aquatic traps disclosed herein can be used for trapping crustaceans such as crab, prawns and shrimp, as well as fish and including flat fish. The traps can include a trap frame surrounded by mesh. The trap frame can include a tapered side which allows nested stacking of traps. The mesh can include floor mesh, side mesh, entrance mesh, and ceiling mesh. The entrance mesh can extend inwardly from a portion of the tapered side, and attach to an entrance frame. A  tensioning element may hold the entrance frame upright inside the trap, or otherwise, the entrance frame can be self-erecting. The ceiling mesh can be releasable to collapse the ceiling and the entrances, thereby facilitating nested stacking of the traps. Date Recue/Date Received 2021-02-25
Patent CA-3111144-A1 (CA)
Inventor: KUBIN WILHELM
IPC: B23C3/00
Filed: 2019-08-06
Abstract: The invention describes a method and a device for machining the running surface (1) of a rail (2) with the help of at least one shaping tool (4) which can be moved along the rail (2) and which can be pressed against the running surface (1) of the rail and rotates and performs machining. It is proposed that after machining with the machining shaping tool (4), at least one rolling body (6) adapted to the shaped rail surface is rolled over the rail in order to level unevennesses of the running surface (1) of the rail (2) while cold forming the running surface (1) of the rail (2).
Patent CA-3112556-A1 (CA)
Title: Systemes et procedes d'identification electronique d'especes vegetales
Inventor: ILIEV IVAN
IPC: G06F16/28
Filed: 2019-09-12
Abstract: La présente invention concerne un procédé consistant : à recevoir une base de données d'images annotée, chaque image comprenant au moins une catégorie d'image, la base de données annotée comprenant des coordonnées de boîte de limitation pour localiser ladite catégorie d'image dans une image. Le procédé consiste : à recevoir des données d'image en temps réel et à utiliser la base de données annotée d'images pour entraîner un modèle de détection d'objet pour détecter et localiser une catégorie d'image dans une trame de données d'image. Le procédé consiste : à détecter et à localiser une catégorie d'image de ladite catégorie d'image à travers des trames d'image des données d'image en temps réel à l'aide du modèle de détection d'objet, la détection et la localisation comprenant la visualisation de l'emplacement dans une vue mise en évidence à travers les trames d'image à l'aide d'un affichage électronique, la détection et la localisation comprenant la capture d'une trame des données d'image en tant qu'image pour la reconnaissance d'image.
Patent CA-3114299-A1 (CA)
Inventor: DOMANKEVICH VERED
IPC: A61P35/00
Filed: 2019-10-31
Abstract: L'invention concerne un procédé de traitement d'un patient atteint d'une tumeur et des kits (200) pour un tel traitement. Le procédé comprend l'administration, au patient, d'une substance (204) qui active des capteurs cytoplasmiques pour un agent pathogène intracellulaire dans la tumeur et le traitement de la tumeur par une radiothérapie alpha-émettrice intratumorale dans les deux semaines d'administration de la substance qui active des capteurs cytoplasmiques pour un agent pathogène intracellulaire dans la tumeur.
Patent CA-3115280-A1 (CA)
Title: Computer vision systems and methods for identifying anomalies in building models
Inventor: ESTEBAN JOSE LUIS
IPC: G06F30/13
Filed: 2019-10-04
Abstract: Computer vision systems and methods for detecting anomalous building models are provided. The systems and methods can detect anomalies in building models using one or more of an independent univariate Gaussian algorithm, a multivariate Gaussian algorithm, a combination of a multivariate Gaussian algorithm for continuous features and a frequency histogram algorithm for discrete features, and/or a bin frequency model. The system automatically processes computerized models to determine anomalies, and indicates whether the models are accurate and whether correction is required.
Patent CA-3115754-A1 (CA)
Inventor: CISKO GEORGE J
IPC: A61K9/14
Filed: 2019-09-24
Abstract: A stoma powder composition is formulated with at least one moisture absorbing material and at least one skin health ingredient. The stoma powder composition is configured to absorb moisture from peristomal skin while improving peristomal skin health.