baber/WOPTO huggingface dataset:
Patent CA-3099645-A1 (CA)
Inventor: CHARNE DAVID GEORGE
IPC: A01H4/00
Filed: 2019-05-30
Abstract: Systems and methods for editing plant genomes include systems and methods for transforming plants generally, and brassica plants particularly, with genome editing systems including CRISPR-Cas. Systems and methods for editing plant genomes include systems and methods for transforming Brassica microspores with genome editing systems and culturing the plant microspores that increase genome editing frequency.
Patent CA-3100404-A1 (CA)
Title: A gantry and apparatus for focussing beams of charged particles
Inventor: BOTTURA LUCA
IPC: G21K5/04
Filed: 2019-05-21
Abstract: A gantry (100) is provided for focussing beams of charged particles having differing momentum to charge ratios to a substantially common point. The gantry comprises: at least one toroidal magnet (10) having a central bore, a primary axis of the toroidal magnet extending along the central bore, the toroidal magnet configured to receive beams of charged particles at different radial locations dependent on the momentum to charge ratio of the beam; wherein the toroidal magnet comprises a plurality of discrete, substantially planar coils (1a, 1b...1p) spaced apart and extending radially from the primary axis (z axis) and configured to produce a magnetic field such that, in use, a first beam of charged particles (30) having a component of motion along the primary axis and entering the toroidal magnet at a first radial location, is directed towards a first point on the primary axis, and; a second beam of charged particles having a different momentum to charge ratio to the first beam, and having a component of motion along the primary axis and entering the toroidal magnet at a second radial location, is directed towards said first point on the primary axis, and wherein; the planar coils are configured to produce a magnetic field that is periodically symmetric about the primary axis, and; the at least one toroidal magnet is substantially stationary in use.
Patent CA-3100544-A1 (CA)
Inventor: ALONSO MICHAEL N
IPC: C07K16/28
Filed: 2019-05-17
Abstract: The invention provides an immunoconjugate comprising (a) an antibody construct comprising (i) an antigen binding domain and (ii) an Fc domain and (b) 1-8 adjuvant cores, wherein each adjuvant core is covalently bonded to the antibody construct via a linker, wherein each adjuvant core comprises a 2-amino nitrogen moiety with a pendant nitrogen atom and a point of attachment of the linker to the adjuvant core, and wherein the distance between the pendant nitrogen atom and the point of attachment of the linker is greater than about 5 Å. The invention also provides methods for treating cancer with the immunoconjugates.
Patent CA-3105247-A1 (CA)
Title: Split transfers with completion after processing failure
Inventor: TAX DAVID SAMUEL
IPC: G06Q20/10
Filed: 2021-01-08
Abstract: In an aspect a computer implemented method includes: obtaining apportionment data for a transfer, the apportionment data defining a plurality of parts of the transfer; and processing the transfer in accordance with the apportionment data, by: processing a pre-authorization for a total amount of the transfer using a first token; after processing the pre-authorization for the total amount of the transfer using the first token, processing one or more of the parts using associated tokens; and completing the transfer by processing a completion of the pre-authorization for an outstanding portion of the transfer, the outstanding portion of the transfer detemiined by adjusting the total amount of the transfer to account for any processed parts.
Patent CA-3106157-A1 (CA)
Inventor: MANDELL DANIEL J
IPC: C12N15/10
Filed: 2019-07-09
Abstract: Provided herein is a stabilized DNase I polypeptide containing a non-standard amino acid that maintains enzymatic activity even under harsh conditions, such as reducing environments. The stabilized DNase I polypeptide has enzymatic activity in reducing environments that is higher than a corresponding DNase I polypeptide without the non-standard amino acids under the same conditions. Also provided herein are polynucleotides encoding the stabilized DNase I polypeptide, cells for expressing and/or producing the stabilized DNase I polypeptide, and methods of use of the stabilized DNase I polypeptide.
Patent CA-3109674-A1 (CA)
Title: System and method for coating of continuous sheets of metal
Inventor: PEARCEY OWEN
IPC: B05D1/18
Filed: 2021-02-19
Abstract: A system and method for affecting the crossbow in a metal sheet in continuous coating process. The system comprises strip distance sensors for determining distances to the metal sheet. A controller is configured to adjust the position of the correcting roll, based on the strip distances, to affect the crossbow in the sheet to help control the thickness of the coating on the sheet. The system may comprise a crossbow model to help determine the new correcting roll position. The distances determined by the strip distance sensors may be also be used to adjust the position of the air knives.
Patent CA-3111202-A1 (CA)
Inventor: SCHEIBEL JOHN P
IPC: B23B51/00
Filed: 2021-03-04
Abstract: Tools and methods for creating a plurality of aligned holes from a plurality of near full-sized holes. The tool includes a cutting member having a first diameter and a pilot member connected to and coaxial with the cutting member. A first section of the pilot member includes a centering member and is positioned between the cutting member and the second section having a second diameter. The centering member may include a cutting surface. The second diameter corresponds to a positional tolerance of misalignment of a plurality of near full-sized holes of the same diameter and a full-size hole diameter. The centering member may have a third diameter between the first and second diameters. The centering member may be tapered. The pilot member may be inserted into a plurality of near-full sized holes and the cutting member may cut through the holes to form a plurality of aligned full sized holes.
Patent CA-3111398-A1 (CA)
Title: Personalized device to automatically detect and reduce muscle spasms with vibration
Inventor: THOMAS CHRISTINE
IPC: A61B5/389
Filed: 2019-09-05
Abstract: A personalized wearable device can detect muscle contractions, such as spasms, and provide vibrational energy that treats these muscle contractions.
Patent CA-3111483-A1 (CA)
Title: Compositions and methods for organ specific delivery of nucleic acids
Inventor: CHENG QIANG
IPC: A61K9/51
Filed: 2019-09-04
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
Patent CA-3111571-A1 (CA)
Title: Infection-induced endothelial amyloid compositions as antimicrobials
Inventor: VOTH SARAH
IPC: A61K38/00
Filed: 2019-09-06
Abstract: The present disclosure relates to compositions and methods for the production of antimicrobial amyloid compositions, and further relates to use of such antimicrobial preparations for the treatment of subjects having drug-resistant microbial infections. Advantageous and/or therapeutic amyloid oligomer immunodepletion methods are also disclosed.
Patent CA-3111891-A1 (CA)
Inventor: MAHR ANDREA
IPC: C12P21/00
Filed: 2016-03-24
Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
Patent CA-3113401-A1 (CA)
Title: Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xi to xx
Inventor: GIROUX RICHARD
IPC: C12Q1/6858
Filed: 2006-10-10
Abstract: Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for diagnostic purposes and/or epidemiological typing.
Patent CA-3116733-A1 (CA)
Inventor: HAYMAKER CARA
IPC: A61K39/39
Filed: 2019-10-18
Abstract: La présente invention concerne des méthodes de traitement du cancer chez des patients ayant une faible expression de gènes CMH de classe I, et chez des patients ayant des taux sériques accrus de PD-L2 par l'administration d'un agoniste de TLR9.
Patent CA-3118117-A1 (CA)
Inventor: ROSLER FRIEDEMANN
IPC: A61C7/00
Filed: 2020-02-18
Abstract: La présente invention concerne un procédé de mesure d'une relation d'articulation temporomandibulaire spécifique à un·e patient·e et son transfert dans un articulateur virtuel (2) à l'aide d'un dispositif (1) comprenant : une liaison de transfert (3) qui peut être fixée depuis son extrémité supérieure vers un arc facial (4) ; un moyen d'impression (5) pour maintenir le matériau d'impression (6) et pour prendre l'empreinte de la mâchoire supérieure et/ou de la mâchoire inférieure du·de la patient·e à travers ledit matériau d'impression (6) ; au moins un premier élément d'ajustement de forme (7) fixé à l'extrémité inférieure de la liaison de transfert (3), pour laisser une empreinte (8) sur le matériau d'impression (6) à placer sur le dispositif de préhension (9) du moyen d'impression (5) faisant saillie hors de la bouche du·de la patient·e.
Patent CA-3118809-A1 (CA)
Title: Mouthpiece with adjustment
Inventor: SIMRELL AUSTYN
IPC: A24D3/18
Filed: 2021-05-17
Abstract: A mouthpiece assembly for use with a vaporizer device includes a mouthpiece having an opening formed axially therethrough from a first end to an opposing second end thereof and an inner tubular member configured to be slidably received within the opening of the mouthpiece. A  sliding of the inner tubular member within the opening of the mouthpiece changes an axial length of the mouthpiece assembly to allow for the mouthpiece assembly to be coupled to a variety of different outer tubular members of differing axial lengths that are compatible for use with the mouthpiece assembly for forming the resulting vaporizer device.
Patent CA-3119618-A1 (CA)
Inventor: YOSHIMI EIJI
IPC: C07K14/47
Filed: 2019-11-15
Abstract: L'invention concerne des polynucléotides qui comporte les séquences de bases suivantes : (a) une séquence de bases codant pour une protéine de fusion d'une protéine effectrice CRISPR déficiente en nucléase et d'un activateur de la transcription, et (b) une séquence de bases codant pour un ARN guide ciblant une région continue, d'une longueur de 18 à 24 nucléotides, située dans une des régions présentées dans les SEQ ID NO : 104, 105, 135, 141, 153 167 ou 172 de la région régulatrice de l'expression du gène de l'utrophine humaine, polynucléotides qui devraient pouvoir être utilisés pour traiter ou prévenir la dystrophie musculaire de Duchenne ou la dystrophie musculaire de Becker.
Patent CA-3120618-A1 (CA)
Title: Method and system of manufacturing an insulated member
Inventor: CWIK TOMASZ
IPC: B25J9/16
Filed: 2019-11-21
Abstract: The present invention is directed to a system and method of manufacturing an insulated member (500). The method comprises the steps of: providing, to a computing cloud (310), geometric data of at least a section of a raw part (501) having at least one application section to be applied with a insulation material (502), determining, using the computing cloud (310), on basis of the geometric data, a movement data for a relative movement between an manufacturing-site applicator (410), adapted to apply the insulation material (502) onto the application section of the raw part (501), - determining, using the computing cloud (310), an amount of the insulation material (502) for applying onto the application section, - generating, using the computing cloud (310), a control data set at least comprising the movement data and the amount of insulation material (502), and - providing the control data set to a manufacturing site control computer (420) site (400) that is remote to the computing cloud (310) and/or a planning site where said geometric data is generated.
Patent CA-3120897-A1 (CA)
Inventor: XIN YANG
IPC: H04W28/00
Filed: 2019-09-10
Abstract: La présente divulgation concerne des modes de réalisation pour contrôler dans le temps une quantité d'utilisateurs accédant à une tranche réseau nouvellement établie. Un premier élément réseau envoie une première demande, y compris au moins un premier et un deuxième renseignement d'indication à un deuxième élément réseau, le premier renseignement indiquant de déclarer le premier renseignement d'au moins une tranche réseau au premier élément réseau et le deuxième renseignement indiquant que la première tranche réseau est une tranche réseau nouvellement établie, une tranche réseau sur laquelle un essai de fonctionnement est réalisé ou une tranche réseau pour laquelle aucun accord de niveau de service n'est signé. Le premier élément réseau reçoit le premier renseignement du deuxième élément réseau et contrôle l'accès d'utilisateur à la première tranche réseau en fonction d'une relation entre la qualité et une exigence de qualité de la tranche réseau.
Patent CA-3122570-A1 (CA)
Inventor: RALSTON TYLER S
IPC: A61B3/10
Filed: 2019-12-12
Abstract: La présente invention concerne des techniques et un appareil pour capturer une image du fond de la rétine d'une personne, identifier la personne, accéder à divers dossiers électroniques (y compris des dossiers de santé) ou des comptes ou des dispositifs associés à la personne, déterminer la prédisposition d'une personne à certaines maladies, et/ou diagnostiquer des problèmes de santé de la personne. Certains modes de réalisation concernent un appareil d'imagerie ayant un ou plusieurs dispositifs d'imagerie pour capturer une ou plusieurs images de l'il/des yeux d'une personne. L'appareil d'imagerie selon l'invention peut comprendre des composants électroniques pour analyser et/ou échanger des données d'image et/ou de santé capturées avec d'autres dispositifs. Selon divers modes de réalisation, l'appareil d'imagerie de l'invention peut être configuré, en variante ou en plus, pour des techniques d'identification biométrique et/ou de détermination d'état de santé, comme décrit dans la description.
Patent CA-3122658-A1 (CA)
Inventor: RAMSDEN NIGEL
IPC: C07D239/36
Filed: 2019-12-13
Abstract: The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of a1-antitrypsin deficiency (A1AD or AATD).
Patent CA-3124444-A1 (CA)
Title: A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
Inventor: PAPANIKOLAOU ELENI
IPC: A61K35/28
Filed: 2020-01-22
Abstract: The present invention provides a combination of compositions comprising i) a composition comprising I) a population of T cells, NK cells or cytotoxic immune effector cells comprising a chimeric antigen receptor specific for a stem cell antigen and/or, II) a) a population of T cells, NK cells or cytotoxic immune effector cells comprising a chimeric antigen receptor specific for a tag of a tagged polypeptide, wherein said tagged polypeptide binds specifically to a stem cell antigen, and ß) said tagged polypeptide, and ii) a composition comprising a) a population of CD34+ hematopoietic stem cells, and b) one or more accessory or contributory cell populations selected from the group consisting of myeloid cell lineages expressing CD14, CD11b, CD11c, CD123, CD33; CD36; CD47, CD66b, CD235a, CD146 and CD326. A method applying these compositions to a subject in need thereof are also provided.
Patent CA-3124646-A1 (CA)
Title: Tilt system field learning and optimization for a work vehicle
Inventor: KARST AUSTIN J
IPC: A01B63/111
Filed: 2021-07-14
Abstract: A work vehicle includes a chassis, and a work implement movably coupled to the chassis and configured to perform a field-engaging function. The work machine also includes an actuator coupled to the work implement and configured to adjust a position of the work implement relative to a ground surface. The work machine further includes a controller in communication with an output device and a communication module. The controller is configured to monitor a location of the work machine via the communication module. The controller is also configured to load a field map from a field map database, the field map identifying at least one impact event comprising a geotagged location. The controller is further configured to display an alert via the output device in response to the location of the work machine approaching within a predetermined distance from the geotagged location.
Patent CA-3125493-A1 (CA)
Inventor: LI YUEMING
IPC: B05C17/01
Filed: 2019-01-04
Abstract: L'invention concerne un pistolet à colle, comprenant une poignée mobile (5) et une poignée fixe (16). La poignée mobile (5) est reliée à la poignée fixe (16) au moyen d'une tige de pivotement (12) et la poignée mobile est en outre pourvue d'un élément d'actionnement (11), l'élément d'actionnement étant pourvu d'une partie d'actionnement (206) coopérant avec un élément de poussée (8); et la tige de pivotement (12) et la partie d'actionnement (206) sont conçues pour avoir un intervalle entre elles, de façon être commutables entre au moins deux engrenages, de telle sorte que l'intensité de la force appliquée à l'élément de poussée (8) par l'élément d'actionnement (11) peut être modifiée. La commutation entre une alimentation rapide et une alimentation à forte intensité peut être réalisée à l'aide du mode de changement d'engrenage commutable et un utilisateur peut effectuer une commutation selon les véritables exigences.
Patent CA-3126023-A1 (CA)
Title: A mountable rack and kit for a motor vehicle and a method of mounting a rack for a motor vehicle
Inventor: BEDARD GUILLAUME
IPC: B60R9/10
Filed: 2021-07-26
Abstract: A mountable bicycle, motorcycle or all-terrain vehicle rack for a motor vehicle having a connector mount operable to connect to the motor vehicle, a pivot arm having distal and proximal ends, the proximal end pivotably connected to the connector mount and an actuator connected to the connecter mount and to the pivot arm and operable to actuate the pivot arm between a lowered position and a raised lowered position relative to the connector mount. The actuator may be configured to be electrically connected to an electric source. The rack additionally includes first securing means adjacent the distal end of the pivot arm to secure a first end of the bicycle, motorcycle or all-terrain vehicle to the pivot arm and second securing means adjacent the proximal end of the pivot arm to secure a second end of the bicycle, motorcycle or all-terrain vehicle to the pivot arm.
Patent CA-3127032-A1 (CA)
Inventor: YAMAUCHI KEI
IPC: B21D26/041
Filed: 2020-03-03
Abstract: L'invention concerne un système de moulage destiné à mouler un tuyau métallique par la dilatation d'un matériau de tuyau métallique chauffé. Le système de moulage selon l'invention comprend : une unité d'alimentation en gaz destinée à acheminer un gaz haute pression dans le matériau de tuyau métallique chauffé afin d'entraîner la dilatation du matériau de tuyau métallique ; une unité d'évacuation destinée à évacuer le gaz qui a entraîné la dilatation du matériau de tuyau métallique et qui a atteint une température élevée ; et une unité de refroidissement destinée à refroidir le gaz s'écoulant à travers l'unité d'évacuation.
Patent CA-3131195-A1 (CA)
Title: Conduite isolee
Inventor: DE BELL HUMPHREY REGINALD
IPC: F16L59/02
Filed: 2020-03-20
Abstract: La présente invention concerne une conduite isolée et son utilisation dans des systèmes qui nécessitent des conduites isolées, tels que des systèmes de chauffage. La présente invention est basée sur l'utilisation, dans une conduite isolée, d'une couche de mousse entre une conduite interne de ladite conduite isolée et un panneau d'isolation sous vide entourant ladite conduite interne pour conférer une durée de vie prolongée au panneau d'isolation sous vide et ainsi une maintenance de valeurs d'isolation stables de ladite conduite isolée dans le temps.
Patent CA-3131768-A1 (CA)
Inventor: LENG LIAN
IPC: A61L27/60
Filed: 2020-03-27
Abstract: The present invention relates to devices including microfluidic devices, e.g. Skin on-Chip (Skin-Chip), for simulating a physiological response to agents and injury, including tattoo injury. In particular, a Skin-Chip is intended for use in replicating the interaction of tattoo ink with skin on a cellular level, including but not limited to mechanisms of wound healing following a tattoo gun and/or tattoo needle induced skin injury; ink particle effects such as pigment retention, pigment distribution and pigment clearance; inflammatory response to foreign particles, i.e. tattoo ink, etc. Further, effects of tattoo inks on simulated microfluidic skin is extended to determine effects of systemic ink exposure upon other organs through use of organ chips, e.g. liver-chips, kidney-chips, Lymph node-chips, etc. In some embodiments, safer ink formulations, e.g. less toxic ink particles, less toxic ink diluents, etc., are contemplated for development and use over currently available tattoo inks and diluents. Further contemplated is using a Tattooed Skin-Chip for developing rapid and non-toxic methods of removal of Tattoos in human skin.
Patent CA-3131961-A1 (CA)
Title: Signaling for turns for autonomous vehicles
Inventor: KUNZ TOBIAS
IPC: B60Q1/34
Filed: 2019-03-08
Abstract: Aspects of the disclosure relate to signaling for turns for a vehicle having an autonomous driving mode. For instance, a trajectory that the vehicle will follow for some period of time into the future may be received. The at least a portion may be processed to identify a turning event, the turning event corresponding to a location where the vehicle plans to turn and for which the vehicle will need to use a turn signal. Whether the trajectory includes a negative turning event located some threshold distance before the turning event may be determined. The negative turning event corresponds to a location along the trajectory where the vehicle could make a turn, but does not plan to make a turn. While the vehicle is operating in the autonomous driving mode, the turn signal of the vehicle may be activated based on the turning event and the determination.
Patent CA-3133827-A1 (CA)
Title: Outil de coupe
Inventor: MERCURI ENNIO
IPC: B26D7/10
Filed: 2020-03-18
Abstract: L'invention concerne un outil de coupe destiné à couper un filet permettant d'emballer des produits carnés, comprenant une lame et une protection. Un circuit de commande est électriquement connecté à la lame, et conçu pour maintenir la température de la lame à une température de coupe comprise dans la plage de 300 °C à 500 °C. La protection définit une cavité intérieure entourant la lame et comprend en outre une fente laissant apparaître une partie de la lame. La protection est en outre façonnée pour définir un entonnoir au niveau d'une extrémité distale de l'outil de coupe menant à la fente de sorte que, lors de l'utilisation, l'entonnoir guide un filet à couper vers la lame. L'outil de coupe peut se présenter sous forme d'outil à main ou sous forme montée sur plan de travail.