Patent SG-11201810861P-A (SG)
Title: Compositions and methods for treating diseases and conditions
Inventor: CHEN BEIBEI
IPC: C07D271/10
Filed: 2015-12-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/094659 Al 16 June 2016 (16.06.2016) WIPO I PCT (51) International Patent Classification: CO7C 211/27 (2006.01) A61K 31/496 (2006.01) CO7C 211/50 (2006.01) A61K 31/497 (2006.01) CO7C 211/54 (2006.01) A61K 31/505 (2006.01) CO7D 207/06 (2006.01) A61P 7/00 (2006.01) CO7D 213/36 (2006.01) A61P 11/00 (2006.01) CO7D 239/26 (2006.01) A61P 11/06 (2006.01) CO7D 249/08 (2006.01) A61P 25/28 (2006.01) CO7D 271/10 (2006.01) A61P 29/00 (2006.01) CO7D 401/04 (2006.01) A61P 33/06 (2006.01) CO7D 403/04 (2006.01) A61P 35/00 (2006.01) A61K 31/495 (2006.01) (21) International Application Number: PCT/US2015/065000 (22) International Filing Date: 10 December 2015 (10.12.2015) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/090,309 10 December 2014 (10.12.2014) US (71) Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 200 Gardner Steel Conference Center, Thackeray And O'hara Streets, Pittsburgh, PA 15260 (US). THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; Office Of General Counsel - PSG IV (024), 810 Vermont Avenue N.W., Washington, DC 20420 (US). (72) Inventors: CHEN, Beibei; 175 Berry Field Ct., Wexford, PA 15090 (US). MALLAMPALLI, Rama, K.; 1401 N. Shevlin Ct., Sewickley, PA 15143 (US). (74) Agent: RUPERT, Wayne; Klarquist Sparkman, LLP, One World Trade Center, Suite 1600, 121 Sw Salmon Street, Portland, OR 97204 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) = (54) Title: COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS (57) : A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or un - branched C 1 _ 10 alkyl, (CH),-NH-(CH),, (CH),-0-(CH 2) ,, or (CH)-C(NH)- (CH) s v -NH-(CH)t,where s, t and v are each, independ- ently an integer from 1 to 5; A and B are each, independently, C6_10 aryl, C6_10aryl-Ci_6alkyl, C3_0 heteroaryl, or C3_0heteroaryl-C1_6a1- kyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; C and D are each, independently, C 3 _, cycloalkyl, C 3 _ 7 cycloalkyl-Ci_6alkyl, C3.7 heterocycloalkyl, C3.7 heterocycloalkyl-C1_6 alkyl, C6_10aryl, C6_10aryl-Ci_6alkyl, C3_0 heteroaryl, or C3_0het- eroaryl-Ci_6alkyl, each optionally substituted with 1, 2 or 3 independently selected R g groups; each R g is, independently, halogen, C1- 6alkyl, C1_6 haloalkyl, hydroxyl, C1_6 alkoxy, C1_6haloalkoxy, amino, Ci_6alkylamino, or di-Ci_6alkylamino; and n 1 and p 1 are each, in- dependently, integers from 1 to 10. 111111111111110111010101111101111111100111011110111111111111111110111111111110111111 W O 20 16/09 465 9 Al