Patent SG-11201900635Q-A (SG)
Title: Chimeric antigen receptors targeting bcma and methods of use thereof
Inventor: FAN XIAOHU
IPC: C12N5/10
Filed: 2017-08-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 February 2018 (15.02.2018) WIP0 I PCT omit VIII °nolo III 1101 mo Imo oimIE (10) International Publication Number WO 2018/028647 Al (51) International Patent Classification: C07K 19/00 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) A61P 35/02 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/CN2017/096938 (22) International Filing Date: 10 August 2017 (10.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2016/094408 10 August 2016 (10.08.2016) CN (71) Applicant (for US only): LEGEND BIOTECH USA INC. [US/US]; 251 Little Falls Drive, Wilmington 19808, New Castle, Delaware (US). (71) Applicant (for CN only): NANJING LEGEND BIOTECH CO., LTD. [CN/CN]; No.6 Building of Nan- jing Life Science Town, No. 568 Longmian Avenue, Jiangn- ing District, Nanjing, Jiangsu 211100 (CN). (71) Applicant (for all designated States except CN, US): LEGEND BIOTECH IRELAND LIMITED [IE/IE]; One Spencer Dock, North Wall Quay, Dublin 1 (IE). (72) Inventors: FAN, Xiaohu; 1067 Armitage Crescent SW, Edmonton, Alberta T6W 0K3 (CA). ZHUANG, Qiuchuan; Room 104, 36th Building, Yuecheng International Garden, No.9, Huashen Street, Yuhuatai District, Nanjing, Jiangsu 210012 (CN). WANG, Pingyan; Wudian Town, Fengyang, Anhui 233113 (CN). WANG, Lin; Room 207, 12th Build- ing, 151# Shuangbai Alley, Xuanwu District, Nanjing, Jiangsu 211100 (CN). YANG, Lei; Pingshan Street, Xieji- aji District, Huainan, Anhui 232052 (CN). HAO, Jiay- ing; Zhushan Road 378#, Wanxin Garden, Jiangning Dis- trict, Nanjing, Jiangsu 211100 (CN). ZHAO, Dan; No.2 Building of Guyangxincun Community, Dingmao Road, Jingkou District, Zhenjiang, Jiangsu 212001 (CN). HE, Xi- an; No.15 Tongxianggongjing, Qinhuai District, Nanjing, Jiangsu 210006 (CN). (74) Agent: CHENG & PENG INTELLECTUAL PROPER- TY LAW OFFICE; 821 Yufei Plaza, 42 Dongzhimenwai Avenue, Dongcheng District, Beijing 100027 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, N AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, cc O DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: CHIMERIC ANTIGEN RECEPTORS TARGETING BCMA AND METHODS OF USE THEREOF (57) : Provided are single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, 0 and multivalent CAR including bi-epitope CAR) comprising one or more anti-BCMA single-domain antibodies. Further provided are N engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and 0 methods of treating cancer are also provided.