baber/WOPTO huggingface dataset:
Patent DE-69909938-T2 (DE)
Inventor: YLIHONKO KRISTIINA
IPC: C12N15/00
Filed: 1999-05-10
Granted: 2004-05-13
Abstract: The present invention relates to novel hybrid anthracyclines generated by cloning of fused genes in a mutated Streptomyces galilaeus strain DSM 11638. Said strain was obtained by mutagenization of the S. galilaeus wild type (ATCC 31615). The aglycone moieties of the compounds obtained are modified alkavinones, caused by the gene products introduces into the mutant, and the sugar moieties are those derived from the host strain, i.e. rhodosamine-2-deoxyfucose-2-deoxyfucose or 2-deoxyfucose-2-deoxyfucose-2-deoxyfucose, or the disaccharide or monosaccharide forms of these.
Patent DE-69910085-T2 (DE)
Inventor: COLANTONIO LAURENT
IPC: B60C17/00
Filed: 1999-07-01
Granted: 2004-05-06
Abstract: Fabric treatment layers (130a, 130b, 132a, 132b) are deployed in the sidewall regions of a runflat tire (100) having a metal-reinforced first ply (120). In one embodiment, parallel cord, reinforced fabric treatment layers (130a, 130b, 132a, 132b) sandwich the metal-reinforced first ply (120) and inhibit buckling of the reinforcing cords (70) of the first ply during runflat operation when the ply cords or wires are bearing compression loads. In another embodiment, a single woven fabric treatment layer (170a, 170b) is disposed in each sidewall region (152, 154) at a location immediately axially inward of the metal-reinforced first ply (160).
Patent DE-69911777-T2 (DE)
Inventor: PORTER R
IPC: A61K47/48
Filed: 1999-07-13
Granted: 2004-04-29
Abstract: The invention relates to pharmaceutical compositions and methods for delivery of therapeutic agents. The methods and composition of the invention can achieve site specific delivery of a therapeutic substance, allowing for lower doses and for improved efficacy, particularly for agents such as oligonucleotides which have presented problems in reaching targeted sites in necessary therapeutic levels. Targeted introduction of ultrasound can be used to promote release of the therapeutic agent. The delivery system includes protein-encapsulated gas-filled microbubbles formed in an N2-depleted or N2-free environment. These microbubbles are smaller and more stable than microbubbles sonicated in the presence of room air.
Patent DE-69919477-T2 (DE)
Inventor: CORNIANI CARLO
IPC: B65B21/24
Filed: 1999-10-12
Granted: 2005-09-08
Abstract: A method and machine (1) for packing a group (2) of products (3), whereby the group (2) of products (3) is fed along a first packing path (P1) and eased onto a central portion (10) of a blank (4) fed underneath the group (2), and in time with the group (2), along a second path (P2) meeting up with the first path (P1); the blank (4) is drawn along said supply path (P2); and at least one further portion (11) of the blank (4) is subsequently folded along a peripheral bend line (17b) of the central portion (10) as the group (2) is pressed with a given pressure against the central portion (10) of the blank (4). <IMAGE>
Patent DE-69920560-T2 (DE)
Inventor: MAEDA MUNEYASU
IPC: G11B7/24
Filed: 1999-04-09
Granted: 2006-02-16
Abstract: A RECORDING MEDIUM INCLUDES A PROGRAM AREA IN WHICH DIGITAL DATA MADE UP OF A HEADER (H), MAIN DATA AND SUB-DATA IS BLOCKED AND RECORDED WITH A VARIABLE NUMBER OF SECTORS, WITH A UNIT SECTOR BEING OF A PRE-SET DATA LENGTH, AND A MANAGEMENT AREA IN WHICH THERE IS RECORDED AN IDENTIFIER FOR DISCRIMINATING THE VARIABLE NUMBER OF SECTORS IN ORDER TO RENDER THE DATA VOLUME OF THE SUB-DATA VARIABLE WITH THE VOLUME OF MAIN DATA IN THE PACKET REMAINING FIXED. THE MOST ILLUSTRATIVE DRAWINGS ARE (FIGURE NOS.6A AND 6D).
Patent DE-69926379-T2 (DE)
Inventor: GUPTA B
IPC: C07B61/00
Filed: 1999-09-02
Granted: 2006-04-13
Abstract: Provided is a new process for the preparation of compositions containing at least one triazine ultraviolet light absorber.
Patent DE-69927520-T2 (DE)
Inventor: EHRHARDT ROLF
IPC: A61K39/00
Filed: 1999-12-08
Granted: 2006-06-22
Abstract: The present invention relates to the use of anti-gamma interferon antibody in an amount effective to block the effect of gamma interferon for preparing a pharmaceutical formulation for treating psoriasis. In a preferred embodiment the anti-gamma interferon antibody is a monoclonal antibody having a binding affinity of at least 10<8>M.
Patent DE-69928278-T2 (DE)
Inventor: REEVES FORREST
IPC: A61K47/20
Filed: 1999-11-15
Granted: 2006-06-14
Abstract: A therapeutic solution and application procedure for curing Nail fungus infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a anhydrous solution of Polyglycol, and including a secondary anti-inflammatory agent. The DMSO acts as a delivery vehicle so that active anti-fungal agents such as Miconazole in combination with an anti-inflammatory compound such as ibuprofen can be delivered directly to fungal infected areas under and around the nail. The DMSO, Miconazole, and ibuprofen are dissolved in a viscous solution of Polyglycol so that the combined ingredients may be applied directly to the affected nails with superior penetration. The therapeutic solution is formulated by dissolving the Miconazole into the Polyglycol over heat and adding the ibuprofen and DMSO over additional heat in a timed process. Repeated applications of the resulting solution on Onychomycosis infected nails over one 4-6 week period yields satisfactory result rates as high as 85-90% without augmenting the therapy with systemic drugs. Most versions of the therapeutic solution are anticipated to not require a prescription.
Patent DE-69932205-T2 (DE)
Inventor: EVANS NIGEL ANTHONY
IPC: A61P43/00
Filed: 1999-05-05
Granted: 2007-06-06
Abstract: Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in the affected joint of a mammal is accomplished by administering a chondroprotective compound of Formula (I): <CHEM>  wherein <CHEM> where A is hydroxy, (C1 - C4)alkoxy, amino, hydroxy-amino, mono-(C1 -C2)alkylamino, di-(C1-C2)alkylamino; X and Y are independently H or (C1 - C2)alkyl; and n is 1 or 2; R<6> is halogen, (C1 - C3)alkyl, trifluoromethyl, or nitro; R<9> is H; (C1 - C2)alkyl; phenyl or phenyl-(C1 - C2)alkyl, where phenyl is optionally mono-substituted by fluoro or chloro; -C(=O)-R, where R is (C1-C2)alkyl or phenyl, optionally mono-substituted by fluoro or chloro; or -C(=O)-O-R<1> , where R<1> is (C1 - C2)alkyl. This treatment ameliorates, diminishes, actively treats, reverses or prevents any injury, damage or loss of articular cartilage or subchondral bone subsequent to said early stage of said degeneration. Whether or not a mammal needs such treatment is determined by whether or not it exhibits a statistically significant deviation from normal standard values in synovial fluid or membrane from the affected joint, with respect to at least five of the following substances: increased interleukin-1 beta (IL-1 beta ); increased tumor necrosis factor alpha (TNF alpha ); increased ratio of IL-1 beta  to IL-1 receptor antagonist protein (IRAP); increased expression of p55 TNF receptors (p55 TNF-R); increased interleukin-6 (IL-6); increased leukemia inhibitory factor (LIF); decreased insulin-like growth factor-1 (IGF-1); decreased transforming growth factor beta (TGF beta ); decreased platelet-derived growth factor (PDGF); decreased basic fibroblast growth factor (b-FGF); increased keratan sulfate; increased stromelysin; increased ratio of stromelysin to tissue inhibitor of metalloproteases (TIMP); increased osteocalcin; increased alkaline phosphatase; increased cAMP responsive to hormone challenge; increased urokinase plasminogen activator (uPA); increased cartilage oligomeric matrix protein; and increased collagenase.
Patent HU-E027154-T2 (HU)
Title: Compositions and methods for treating and diagnosing cancer
Inventor: GURNEY AUSTIN
Filed: 2008-07-02
Abstract: The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells
Patent SI-1893196-T2 (SI)
Title: Diarylhydantoin compound
Inventor: SAWYERS CHARLES L
IPC: C07D403/00
Filed: 2006-03-29
Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Patent TR-200002462-T2 (TR)
Title: Kristalimsi organik bileşiklerin dengeli şekilli parçacıkları
Inventor: SAVOIR JOHN CLAUDE
IPC: A61K9/18
Filed: 1999-02-10
Abstract: Mevcut bulusta, alotropik organik bilesiklerin depolama dengeli, sekilli parçaciklari saglanir. Mevcut bulusun parçaciklari  arzu edilen uygulamaya göre sekillendirilebilir. Bu tür parçaciklarin tercih edilen sekilleri mikrosferler, özellikle de yaklasik 1 ila yaklasik 1,000 mikronluk çapa sahip olan mikrosferlerdir. Mevcut bulusun dengeli sekilli parçaciklari özellikle farmasötik formülasyonlarin, özellikle de sürekli salim ve tekbiçimli biyo yararlilik arzu edilen durumlarda imalati için uygundur. Depolama dengeli parçaciklar, alotropik organik bilesiklerin bir kati hal kristallestirilmesi ile olusturulurlar. Mevcut bulusun kati  hal kristallestirme islemi ile orjinal parçacik boyutlari bozulmadan veya kaybolmadan sözkonusu alotropik bilesigin depolama dengeli kristalimsi bir halinin elde edilmesi için bir bir araç saglanmis olur.
Patent TR-200003889-T2 (TR)
Title: Saç ve/veya baş derisinin tedavisi için uygulama dişi
Inventor: MARCO JUAN CARLOS CLEMENTE
IPC: A45D19/02
Filed: 1999-06-30
Abstract: Bu bulus, bugün kullanilan hem sivi hem de yapiskan ürünlerin uygulanmasi için, ancak daha temzi ve daha hizli bir uygulama sayesinde söz konusu ürünlerin kullanilan miktarinda da büyük bir tasarruf saglayan, mevcut sistemlerin getirdiginden daha büyük faydalar saglayan, saç ve/veya kafa derisi ile ilgili islemler için bir uygulama disi ile ilgilidir.
Patent TR-200200495-T2 (TR)
Inventor: GILLHAM PETER JOHN
IPC: G01J1/02
Filed: 2000-08-23
Abstract: A method of fabricating a micro-bridge device ( 14, 16 ) onto a substrate ( 20 ). The method includes the steps of: providing a sacrificial material ( 32 ) on a surface region of the substrate ( 20 ); patternwise etching the sacrificial material ( 32 ); providing a sensing material ( 34 ) on a surface region of the sacrificial material; providing a support material ( 36 ) on a surface region of the sensing material; and removing the sacrificial material ( 32 ) leaving support material ( 36 ) with the sensing material ( 34 ) on its lower surface, substantially free standing above the substrate ( 20 ).
Patent DE-602004006153-T2 (DE)
Inventor: GUMINSKI YVES
IPC: A61P35/00
Filed: 2004-09-16
Granted: 2007-12-27
Abstract: Crystalline epipodophyllotoxin 4'-demethyl-4'-phosphate 2'',3''-bis-(pentafluorophenoxyacetyl)-4'',6''-ethylidene-beta -D-glucoside (I), as free base or hemiethanolate, is new. Crystalline epipodophyllotoxin 4'-demethyl-4'-phosphate 2'',3''-bis-(pentafluorophenoxyacetyl)-4'',6''-ethylidene-beta -D-glucoside, as free base or hemiethanolate (both characterized by X-ray diffraction diagrams given in the specification), of formula (I), are new. [Image] n : 0 or 0.5. An independent claim is included for the preparation of (I). ACTIVITY : Cytostatic. In tests in mice with implanted P388 leukemia, a single intraperitoneal injection of the crystalline hemiethanolate (I; n = 0.5) at 40 mg/kg or 160 mg/kg gave T/C values of 143% and 329%, respectively, compared with 100% (i.e. no effect) and 157% respectively for amorphous (I) at 40 mg/kg and 160 mg/kg. MECHANISM OF ACTION : Topoisomerase-1 inhibitor; Topoisomerase-2 inhibitor.
Patent DE-602004006299-T2 (DE)
Inventor: WEISS PIERRE
IPC: A61L27/46
Filed: 2004-11-04
Granted: 2008-04-10
Abstract: The use of a hydrogel (A), formed from silanated hydroxyethyl cellulose (HEC) or silanated hydroxypropyl methyl cellulose (HPMC) and self-crosslinkable as a function of pH, is claimed for the 3-dimensional culture of chondrocytes. An independent claim is included for an ex vivo method for a complex of cells integrated into a hydrogen, as a complex for injection into a cartilage site, involving mixing chondrocytes with (A) in vivo, in a biological buffer of pH suitable for crosslinking of (A), under conditions and for a time suitable for the integration and 3-dimensional culture of the chondrocytes in (A).
Patent DE-602004008122-T2 (DE)
Inventor: KOVACS LASZLO F
IPC: C08G18/76
Filed: 2004-01-26
Granted: 2008-05-15
Abstract: The subject of the patented process is the decrease of the acidic content of polymethylene-poly-phenyl-polyisocyanates mixtures by the application of acid sorption material of mineral origin. This acid sorption material is an alkaline mineral with large specific surface area or a synthetically produced inorganic compound, which can be used in the form of powder, granule or other forms of similar nature. The treatment is made by effectively contacting the PMDI and the acid sorption material, and by their subsequent separation. The resulted mixture is proper for the production of polyurethanes.
Patent DE-602004008289-T2 (DE)
Inventor: NOOREN FRANS
IPC: C08K3/00
Filed: 2004-07-14
Granted: 2008-05-08
Abstract: The invention relates to a composition for the protection of a shaped article against corrosion, said composition comprising (a) a polyisobutene having a glass transition temperature of less than −20° C. and surface tension of less than 40 mM/m at a temperature above the glass transition temperature of said polyisobutene, (b) a filler material and (c) an anti-oxidant composition. The anti-oxidant composition comprises a primary and/or a secondary anti-oxidant, the primary anti-oxidant being selected from the group consisting of sterically hindered phenol compounds. The invention further relates to a wrapping tape comprising said composition for the protection of a shaped article, a process for the manufacture of said wrapping tape and a process for covering a shaped article with said wrapping tape.
Patent DE-602005002172-T2 (DE)
Inventor: PIOT JACQUES
IPC: A47L13/22
Filed: 2005-04-15
Granted: 2008-05-21
Abstract: The cleaning appliance (1) consists of a steam generator (2) and a handle (3) connected to a cleaning head (4) that has a sole plate covered with a cloth (6) and set adjacent and parallel to a steam dispenser (7), with a tube (8) feeding the steam from the generator to the dispenser. The handle is connected to the cleaning head by a universal joint (9), and the steam feed tube (8) is separate from the handle.
Patent DE-602005004619-T2 (DE)
Inventor: GERLACH CHRISTIAN DR ING
IPC: H04W16/04
Filed: 2005-11-04
Granted: 2009-04-30
Abstract: The invention concerns a method for automatic resource restriction distribution for coordination of the interference between cells (C1, C2,...) or sectors (S1, S2, ...) of a single frequency network with the frequency band being subdivided into at least two subsets (F1 F2...FR), whereby mobile terminals (T1) in the single frequency network perform power measurements of pilot symbols, based on said power measurements, the signal to interference ratio and the data throughput in the cells (C1, C2, ...) in case of no interference coordination and in case of interference coordination is calculated, and at least one dedicated subset of said at least two subsets (F1 F2...FR) is chosen for usage with restricted power in such a way that the overall data throughput in the cells (C1, C2, ...) is maximized, a base station, a mobile terminal, a resource distribution device and a mobile network therefor.
Patent DE-60123593-T3 (DE)
Inventor: BURNS CHARLES
IPC: B01J3/06
Filed: 2001-04-02
Granted: 2010-01-28
Abstract: The invention provides a method of changing a grey type IIb diamond from grey to blue or enhancing the colour of a type IIb diamond. Selected conditions of high temperature and high pressure are used to produce the colour change.
Patent DE-60312309-T3 (DE)
Inventor: BROOKS GREGORY F
IPC: C07K14/33
Filed: 2003-03-24
Granted: 2011-02-24
Abstract: The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease.
Patent DE-69216899-T3 (DE)
Inventor: POULETTY PHILIPPE
IPC: A61K47/48
Filed: 1992-04-22
Granted: 2004-01-15
Abstract: Novel conjugates are provided comprising a moiety capable of specifically binding to a target cell joined to a selective moiety for binding to an endogenous effector agent, capable of causing cell inactivation or cytotoxicity. Example of conjugates are a ligand for a surface membrane protein, e.g. IL-2 receptor, joined to a polysaccharide A or B antigen. The conjugates may be used to specifically destroy cells associated with a pathogenic condition.
Patent DE-69500040-T3 (DE)
Inventor: HANSENNE ISABELLE
IPC: A61K8/00
Filed: 1995-05-05
Granted: 2000-12-21
Abstract: Cosmetic compsns. for topical use contain a solubilised UV filter (I) comprising 4-methylbenzylidene-camphor (Ia) and/or 4-t-butyl-4'-methoxy-dibenzoylmethane (Ib) and a solubilising UV filter (II) comprising homomenthyl salicylate (IIa) and/or octyl salicylate (IIb). Also claimed is a cosmetic treatment process for protecting the skin and/or hair against UV radiation, esp. sunlight, comprising application of a compsn. as above.
Patent DE-69635400-T3 (DE)
Inventor: ARBOGAST ROBERT E
IPC: A61F2/00
Filed: 1996-03-20
Granted: 2013-03-07
Abstract: The invention relates to a polymeric gel and various articles of manufacture such as a cushion liner, a cushion locking liner, an open-ended cushion knee or elbow sleeve, and a cushion flat sheet, all useful for increasing the comfort of the wearer. Also described are sleeve members and liners for enclosing an amputation stump. The polymeric gel composition preferably comprises a block copolymer and mineral oil.
Patent DK-1099676-T3 (DK)
Inventor: WEGNER CHRISTOPH DR
IPC: C07C41/50
Filed: 2000-08-25
Granted: 2004-01-12
Abstract: A process for the preparation of 1,1,4,4-tetramethoxy-2-butene by reacting 2,5-dimethoxydihydrofuran with methanol in the presence of acids comprises carrying out the reaction in the presence of solid catalysts having acidic centers.
Patent DK-1188686-T3 (DK)
Inventor: OSTENDORF MICHAEL
IPC: B65D81/24
Filed: 2000-09-08
Granted: 2004-08-16
Abstract: The open side of a coating composition (4) packaged in a closable container (2) is covered with a bactericidal and/or germicidal layer (5). An Independent claim is also included for a spray device having a nozzle for applying a mist of the biocide which forms the layer.
Patent DK-1043235-T3 (DK)
Inventor: SAFIAN JOHN W
IPC: B29C49/04
Filed: 2000-03-31
Granted: 2003-09-22
Abstract: A multilayer container (10) for dispensing product that includes a relatively rigid outer body (12) and a relatively flexible inner liner (14) for holding product to be dispensed. The relatively rigid outer body includes, and preferably consists essentially of, an outer layer (22) of virgin polyethylene such as HDPE, and an inner thicker layer (24) that includes polyethylene regrind. The relatively flexible inner liner includes, and preferably consists essentially of, an outer delamination layer (26) adjacent to the inner layer of the body and composed of nylon, nylon blends or EVOH, an inner layer (28) of polyethylene such as LLDPE, and an adhesive securing the inner and outer layers of the liner. The relatively thin outer HDPE layer on the plastic body provides desired appearance, while the thicker inner layer provides structural rigidity using reground plastics. The nylon, nylon blend or EVOH outer liner layer provides improved barrier properties against migration of water, gases and flavorants, while the inner layer of LLDPE provides primarily enhanced flexibility and freedom from cracking, as well as additional barrier moisture qualities. <IMAGE>
Patent DK-1177317-T3 (DK)
Inventor: HOGAN JAMES J
IPC: C12Q1/689
Filed: 2000-05-03
Granted: 2006-12-11
Abstract: Polynucleotide probes and accessory helper oligonucleotides useful for detecting bacteria that are members of the genus Staphylococcus. The hybridization probes are highly specific for Staphylococcal bacteria and do not cross-hybridize with the rRNA or rDNA of numerous other bacterial and fungal species.
Patent DK-1189900-T3 (DK)
Inventor: TAKAKI KATHERINE S
IPC: C07D405/04
Filed: 2000-06-06
Granted: 2004-04-26
Abstract: There is provided a novel series of heterocyclic aminopyrrolidine compounds of Formula Iwherein R1, R2, R3, R4, W, Z and the wavy bond <CUSTOM-CHARACTER FILE="US06211225-20010403-P00001.TIF" ID="CUSTOM-CHARACTER-00001"> are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.
Patent DK-1215976-T3 (DK)
Inventor: SMAL HENRI
IPC: A45D20/12
Filed: 2000-08-29
Granted: 2004-05-17
Abstract: The electrical apparatus has a body (1) with a series of functional elements and a handle (11) presenting a battery of control elements (2) permitting the user to activate and regulate this apparatus. The handle comprises a barrel (12), which is movable about its axis, and the battery of switches is fixed to the barrel and movable with it.
Patent DK-1215459-T3 (DK)
Inventor: KAISER VICTOR
IPC: C10G70/04
Filed: 2001-11-29
Granted: 2005-08-15
Abstract: A process for the high-yield recovery of ethylene and heavier hydrocarbons from the gas produced by pyrolysis of hydrocarbons in which the liquid products resulting from the fractionated condensation of a cracking gas for the recovery of almost all the ethylene, are supplied to a distillation column, called a de-ethanizer, at different intermediate levels. At the top of the de-ethanizer the vapor of the column distillate is treated directly in an acetylene hydrogenation reactor, the effluent containing virtually no acetylene being separated by a distillation column called a de-methanizer, into an ethylene- and ethane-enriched tail product, while the head product is recycled by compression or treated for subsequent recovery of ethylene.
Patent DK-1249511-T3 (DK)
Inventor: LIEBFAHRT WERNER
IPC: C22C38/60
Filed: 2001-12-05
Granted: 2007-01-15
Abstract: Steel object produced by decomposing a liquid metal stream of an alloy with nitrogen to form a metal powder and compacting the powder with optional deformation comprises a chemical composition containing (in weight %) 1.51-2.5 carbon, up to 0.8 silicon, up to 1.5 manganese, 3.5-4.5 chromium, 13.3-15.3 tungsten, 2.0-3.0 molybdenum, 4.5-6.9 vanadium, 10.05-12.0 cobalt, up to 0.52 sulfur, up to 0.2 nitrogen, maximum 100 ppm oxygen, and a balance of iron. The amount of manganese minus sulfur is at least 0.19. The ratio of concentrations of tungsten to molybdenum is 52.-6.5. Preferred Features: The steel has the following composition (in weight %) 1.75-2.38 C, 0.35-0.75 Si, 0.28-0.54 Mn, 3.56-4.25 Cr, 13.90-14.95 W, 2.10-2.89 Mo, 4.65-5.95 V, 10.55-11.64 Co and 0.018-0.195 N.