Patent GB-970480-A (GB)
Title: 1:2:4-triazoles and processes for the preparation thereof
IPC: C07D249/08
Filed: 1961-12-27
Abstract: The invention comprises compounds of the general formula <FORM:0970480/C1/1> (wherein R1 represents an aryl radical optionally carrying one or more halogen or C1-7 alkyl or alkoxy substituents, R2 represents a hydrogen atom, a saturated hydrocarbon radical of not more than 9 carbon atoms, an aralkyl radical or an aryl radical optionally carrying one or more halogen or C1-7 alkyl or alkoxy substituents, alk represents a straight or branched alkylene chain of not more than 6 carbon atoms with at least 2 carbon atoms separating the triazole ring from the NR3R4 group, and each of R3 and R4, which may be the same or different, represents a hydrogen atom, a hydroxyalkyl or an alkyl radical such that when both R3 and R4 represent alkyl radicals these together contain not more than 12 carbon atoms, or R3 and R4 form a ring structure (which may contain an oxygen atom or a C1-5 alkyl-substituted imino group) by being joined together when both are alkyl groups or by one or both being joined to alk when one or both are alkyl groups) and their acid addition salts, and pharmaceutical compositions containing these compounds together with a pharmaceutical carrier, and the preparation of the compounds by the following processes: (a) condensing an amine of the general formula <FORM:0970480/C1/2> with a hydrazine derivative of the general formula <FORM:0970480/C1/3> (wherein R2 represents an aryl radical optionally carrying one or more halogen or C1-7 alkyl or alkoxy substituents) or with a 1,3,4-oxadiazole of the general formula <FORM:0970480/C1/4> (wherein R2 represents a hydrogen atom, a saturated hydrocarbon radical of not more than 9 carbon atoms or an aralkyl radical; (b) (when neither R3 nor R4 is joined to alk) condensing a compound of the general formula <FORM:0970480/C1/5> (wherein Z represents the radical of a strong inorganic acid or of a sulphonic acid) with an amine HNR3R4; (c) (when R4 is an alkyl or hydroxyalkyl radical independent of R3 and alk) N-alkylating or N-hydroxyalkylating the corresponding compound in which R4=H; (d) (when R4=H) splitting off the acyl radical from the corresponding compound in which R4=acyl; (e) (when neither R3 nor R4 is hydrogen or hydroxyalkyl) condensing a compound of the general formula <FORM:0970480/C1/6> with a hydrazide H2N-NH-CO-R5 (wherein one R5 is the same as R1 and the other is the same as R2, and X represents a chlorine or bromine atom) or (f) condensing a compound of the general formula <FORM:0970480/C1/7> with an acid R5-COOH or an ester, acid halide or anhydride thereof.  The pharmaceutical compositions (which stimulate breathing, reduce appetite and/or lower the blood pressure) may be in forms suitable for enteral, parenteral or topical application, e.g. tablets, dragees, solutions, suspensions, emulsions or ointments.  Triazoles of the fourth general formula above are prepared by condensing a compound of the second general formula above with an alkanolamine and converting the hydroxy group in the product to Z (e.g. to a sulphonic acid ester group by the action of a sulphonic acid chloride in the presence of pyridine).  Bis-(a -chlorobenzylidene)-hydrazines of the second general formula above (R1R2=phenyl, o-chlorophenyl or p-t-butylphenyl, X=Cl) are prepared by treating compounds of the general formula R1CONH.NHCOR2 with phosphorus pentachloride in o-dichlorobenzene. N-Benzoyl-N1-o-chlorobenzoylhydrazine is prepared by reacting benzhydrazide with o-chlorobenzoyl chloride in suspension in aqueous caustic soda.  4-(11-Methyl-21-aminoethyl)-morpholine is prepared by reducing a -morpholinopropionitrile with lithium aluminium hydride. N-Methyl-N1-(b -aminoethyl)-piperazine is prepared by reacting N-methylpiperazine with formaldehyde and sodium cyanide in aqueous hydrochloric acid to form N-methyl-N1-cyanomethylpiperazine and catalytically hydrogenating this product.  N,N-Diethyl-N1-(a -chlorobenzylidene) - 1, 2 -ethanediamine hydrochloride and its p-t-butyl derivative are prepared by refluxing N,N-diethyl-N1-benzoyl-1,2-ethanediamine and its p-t-butyl derivative with phosphorus pentachloride in benzene. N,N-Diethyl-N1-p-t-butylbenzoyl-1,2-ethanediamine is prepared by treating N,N-diethyl-1,2-ethanediamine with p-t-butylbenzoyl chloride in aqueous caustic soda.  3,5-Diphenyl- and 3-phenyl-5-(p-t-butylphenyl)-4-(21-acetylaminoethyl)-1,2, 4-triazole are prepared by refluxing bis-(a -chlorobenzylidene)-hydrazine and N-(a -chlorobenzylidene)-N1-(a -chloro-p-t-butylbenzylidene) -hydrazine respectively with N-acetyl-1, 2-ethanediamine in absolute ethanol.  Specification 396,778 is referred to.