baber/WOPTO huggingface dataset:
Patent DE-69531242-T2 (DE)
Inventor: BROMIDGE S
IPC: C07D487/18
Filed: 1995-05-09
Granted: 2004-05-27
Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof:    <IMAGE>  (I)  wherein R1 represents   <IMAGE>   in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl or a group OCOR5 where R5 is hydrogen or R4; and R3 is CN; said process comprising reacting a compound of formula (II):    <IMAGE>  (II)  wherein R1' is R1 or a group convertible thereto, and R3' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting =NOH group to =NR2 wherein R2 is as defined in formula (I), converting R1' and R3' when other than R1 and R3 to R1 and R3, and thereafter optionally forming a pharmaceutically acceptable salt.
Patent DE-69532984-T2 (DE)
Inventor: BACKUS JOHN WESLEY
IPC: C12Q1/6832
Filed: 1995-09-14
Granted: 2005-05-04
Abstract: Multiple target nucleic acids are amplified using polymerase chain reaction in the presence of a nonionic, polymeric volume exclusion agent. The amplification efficiency of low copy target nucleic acids is increased in the presence of the volume exclusion agent even though reduced primer levels are used. In this manner, amplification efficiency of a given target nucleic acid can be more readily manipulated.
Patent DE-69534782-T2 (DE)
Inventor: PLEE DOMINIQUE
IPC: B01D53/26
Filed: 1995-11-16
Granted: 2006-11-09
Abstract: A unit for drying natural gases contg. amine (III) traces comprises operating thermal adsorption/desorption cycles using a zeolite (I) and agglomerated kaolinite-gp. clay (II) as the absorbing agents.
Patent DE-69609271-T2 (DE)
Inventor: BRILMAN WILLEM
IPC: B65D85/73
Filed: 1996-04-03
Granted: 2001-01-04
Abstract: A metal container (19) for beer comprises: a wall formed into a closed contour; a base (18) which is connected along its whole periphery to this wall; optionally a cover which is arranged on the side remote from the base after filling of the container with beer and which is connected along its whole periphery to this wall; and a cartridge (22) which is coupled to the base and extends from the base over some axial distance and which defines two passages, the first (32) of which is situated in an end wall of the cartridge remote from the base and the second of which is situated in the region of the base; which cartridge has the general shape of a beaker, which beaker is coupled with the edge zone (23) of its mouth to the base (18) of the container by means of coupling means. The container according to the invention has the feature that the coupling means (21, 28) are exclusively mechanical and are embodied such that between the edge zone (23) of the cartridge and the base (18) of the container there remains some space, which space defines the second passage. It should be understood that the cartridge can be fixed more or less loosely to the base.
Patent DE-69610880-T2 (DE)
Inventor: RODRIGUEZ MICHAEL JOHN
IPC: A61K38/12
Filed: 1996-07-22
Granted: 2001-05-10
Abstract: Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: <CHEM>  wherein:     R<z1> is hydrogen, -CH2OH, -CHOHCH3 or -CHOHCH2C(O)NH2;     R<z2> is hydrogen, -CH2OH or -CHOHCH3;     R<z3> is hydrogen or methyl;     R<x1> is hydrogen, hydroxy or O-R<x1'>; R<x1'> is C1-C6 alkyl, benzyl, -(CH2)2Si(CH3)3, -CH2CH=CH2, -CH2CHOHCH2OH, -(CH2)aCOOH, -(CH2)bNR<w1>R<w2>, -(CH2)cPOR<w3>R<w4> or -Ä(CH2)2OÜd-(C1-C6)alkyl;     a, b and c are independently 1, 2, 3, 4, 5 or 6; R<w1> and R<w2> are independently hydrogen, C1-C6 alkyl, or R<w1> and R<w2> combine to form -CH2(CH2)eCH2-;     R<w3> and R<w4> are independently hydroxy, or C1-C6 alkoxy;     d is 1 or 2;     e is 1, 2 or 3; R<x2>, R<y1>, R<y2>, R<y3> and R<y4> are independently hydroxy or hydrogen;     R<0> is hydroxy, -OP(O)(OH)2 or a group of the formulae: <CHEM> R<1> is C1-C6 alkyl, phenyl, p-halo-phenyl, p-nitrophenyl, benzyl, p-halo-benzyl or p-nitro-benzyl;     R<2> is <CHEM>     R<3> is <CHEM>   <CHEM>   <CHEM>  or <CHEM> R<3a>, R<3b>, R<3c> and R<3d> are independently hydrogen, C1-C12 alkyl, C2-C12 alkynyl, C1-C12 alkoxy, C1-C12 alkylthio, halo, -O-(CH2)m-ÄO-(CH2)nÜp-O-(C1-C12 alkyl) or -O-(CH2)q-X-R<4>;     m is 2, 3 or 4;     n is 2, 3 or 4;     p is 0 or 1;     q is 2, 3 or 4;     X is pyrrolidino, piperidino or piperazino; and R<4> is hydrogen, C1-C12 alkyl, C3-C12 cycloalkyl, benzyl or C3-C12 cycloalkylmethyl; with the proviso that at least one of R<z1> and R<z2> must be hydrogen; or a pharmaceutically acceptable salt thereof.t
Patent DE-69613949-T2 (DE)
Inventor: LIOU SHIH-PING
IPC: G11B27/28
Filed: 1996-11-19
Granted: 2001-11-22
Abstract: Apparatus for detecting a cut in a video comprises arrangements for acquiring video images from a source, for deriving from the video images a pixel-based difference metric, for deriving from the video images a distribution-based difference metric, and for measuring video content of the video images to provide up-to-date test criteria. Arrangements are included for combining the pixel-based difference metric and the distribution-based difference metric, taking into account the up-to-date test criteria provided so as to derive a scene change candidate signal and for filtering the scene change candidate signal so as to generate a scene change frame list. <IMAGE>
Patent DE-69624347-T2 (DE)
Inventor: MOSKOVICH ROBERT
IPC: A46B9/04
Filed: 1996-03-18
Granted: 2003-08-07
Abstract: An improved toothbrush with a secure grip, a more effective bristle arrangement, and a specially shaped head is disclosed. The handle is formed with opposed gripping portions, and fits securely in the hand of the brusher, facing either up or down, imparting to the user a very secure and comfortable feeling. The toothbrush has a narrow and thin head for maximum access to the oral cavity, and a novel bristle arrangement which is highly effective for the removal of plaque from teeth with manual brushing. In one embodiment, the brush head is tapered to a narrow portion, and then optionally flares out again. In another embodiment, the head is formed with a wavy profile. In yet other embodiments, the brush head may also be provided with an upwardly curved or an angled tip. The head may also have a rubberized lower portion to effectuate gum massage, a gum stimulator, and a head with visibly different utilization areas.
Patent DE-69626039-T2 (DE)
Inventor: LAGUETTE W
IPC: F16K15/16
Filed: 1996-11-05
Granted: 2004-01-22
Abstract: The length of dwelling of a voice prosthesis in the fistula of a patient is extended by supporting the soft hollow body of the prosthesis with an elongated, rigid cartridge and mounting the flapper valve by means of a tab which extends through a slot in the flange of the cartridge. An enlarged cavity in the flange or the body communicates with the slot and receives the leading portion of the tab. The cavity is filled with adhesive to secure the valve to the cartridge.
Patent DE-69628597-T2 (DE)
Inventor: PALOMO COLL ALBERTO
IPC: C07D521/00
Filed: 1996-12-20
Granted: 2004-04-22
Abstract: Preparation of 2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)-propan-1-ol (fluconazole) of formula (I) and its salts involves reacting a 2-(2,4-difluorophenyl)-1-hydrazino-propan-2-ol derivative of formula (IV) or its salt with s-triazine in an organic solvent under acidic conditions at -60 deg C to reflux temperature. Ar = 2,4-difluorophenyl; R = H, benzyl, triphenylmethyl or COOR1; R1 = alkyl or aryl, preferably tert. butyl or ethyl; Z = triazolyl or NHNHR. Compounds (IV) and their salts are new. Also new are intermediate halo compounds of formula (VIII).
Patent DE-69719510-T2 (DE)
IPC: A63B23/04
Filed: 1997-04-11
Granted: 2004-02-19
Abstract: This invention can be profitably employed in the fields of medicine and sports in the machines used to strengthen the muscles of the knee and in knee tutors.In its simplest version, the articulated joint is formed by two plates (1, 2) which can move freely on one another; alternatively, one plate (1) or the other (2) can be fastened to a fixed structure by means of a fastener.One of the plates features two openings (2.2, 2.3), where the first (2.2) is located at the center of a plate and is shaped like a rectangle. The second opening (2.3) has a specific shape: at first it is a circumference whose radius is equal to "I"; subsequently, it is a spiral which returns towards the center of the plate (2).The other plate features two pins (1.2 and 1.3), located at a distance "I"; the first pin (1.2) is located in the central position and is inserted into opening the (2.2); the second pin (1.3) is in a peripheral position and is located in the second opening (2.3).Alternatively the plate (2) can be replaced by several overlapping plates (3, 4, 5, 6, 7); the semi-plates are arranged in overlapping couples (4, 7 and 5, 6). The semi-plates (4, 7) are fastened to the plate (3) by means of a pin (4.1) placed in an ideal point of rotation (11) and are therefore free to rotate onto the semi-plates (5, 6).
Patent DE-69721017-T2 (DE)
Inventor: BRACCO UMBERTO
IPC: A23L23/00
Filed: 1997-06-04
Granted: 2003-11-06
Abstract: Extracting antioxidants from olives comprises crushing the olives; drying the crushed olives under vacuum; pressing the dried olives to obtain a lipid fraction (II) rich in antioxidants and a cake; carrying out an extraction on the cake by MCT (sic) or with a 2-6C alkene glycol (III) at a pressure ≥ 40 bars; and obtaining an antioxidant rich extract (IV) from the cake. Also claimed are (i) (II) and (IV); (ii) food or cosmetic products containing 0.5-4 wt.% of (IV) or containing (II).
Patent DE-69724652-T2 (DE)
Inventor: FOSTER STEPHEN
IPC: C22C/
Filed: 1997-12-18
Granted: 2004-03-25
Abstract: According to the present invention there is now provided a cemented carbide drill/endmill blank consisting of a core and a surrounding tube with improved technological properties. The difference in Co-content between the core and tube is 1-10 wt.% units and the cubic carbide content is 8-20 wt.% in the tube and 0.5-2 wt.% in the core. The invention also relates to the method of making said cemented carbide drill/end mill blank.
Patent DE-69805822-T2 (DE)
Inventor: BELLINI GIOVANNI
IPC: D06B5/16
Filed: 1998-09-23
Granted: 2003-01-23
Abstract: A plant for dyeing and processing of yarns on reels comprising at least one processing station (11, 12, 13) with a processing device receiving reels stacked on vertical rods (25, 125). The processing device has an upper opening for loading and unloading the reels and the vertical rods are engaged in a removable manner in seats in said device. A rod-grasping unit (15, 115) is movable vertically and horizontally to be arranged above the opening in the processing device to grasp the rods (25, 125) and hoist them with the reels thereon out of the device or insert them in place in the device. In case of a plurality of stations passage between the stations is in this manner fully automatic.
Patent DE-69809207-T2 (DE)
Inventor: HOCKNEY L
IPC: F16C32/04
Filed: 1998-03-13
Granted: 2003-07-10
Abstract: A power supply device for providing uninterrupted power for a period of time is disclosed. The power supply device has a controller and a flywheel device. The flywheel device has a housing that contains a flywheel rotor and a motor/generator rotor. The flywheel rotor and the motor/generator rotor are mounted on a common shaft. An active axial magnetic bearing is located to support the shaft for frictionless rotation. The bearing provides support for the shaft, the flywheel rotor and motor/generator rotor. The axial magnetic bearing is attached to the housing and provides, in combination with the motor/generator rotor, a flux path and magnetic field to exert a magnetic force to lift the motor/generator rotor and the shaft on which it is mounted.
Patent DE-69810413-T2 (DE)
Inventor: ROUDIER FABRICE
IPC: B25B5/12
Filed: 1998-09-30
Granted: 2003-11-27
Abstract: The movable element (3) and rod (8) of the operating component (5) are interconnected by a longitudinally adjustable assembly. This assembly comprises a threaded hole (9) in the rod interacting with the externally threaded end (11) of a connecting element on the movable element. The connecting element is connected to the movable element so that it is twist-free. The connecting element has a protrusion (14) which interacts with an end position sensing component (15) on the clamping or holding position.
Patent DE-69813252-T2 (DE)
Inventor: RAMM-SCHMIDT LEIF
IPC: B01D1/22
Filed: 1998-01-22
Granted: 2004-05-13
Abstract: The invention relates to a heat exchange element (1) which is made up of a bag of a film material, such as plastic film, and to a heat exchanger made up of such heat exchange elements, the heat exchanger being suitable, for example, for the evaporation of effluents which contain solid matter, such as effluents from bleaching. The transfer of heat takes place in the bags (1) from a vapor condensing in the interior (3) of the bags to a liquid evaporating on their exterior surfaces (2). The forming evaporated vapor may be recycled via a compressor to the interior of the bags as heating vapor so that the heat exchanger will function as a distillation apparatus. According to the invention there is bonded inside the bag (1) a planar condensate-removal member, substantially narrower than the bag, for example, a circular disc (9) to which the forming condensate is arranged to flow and in which there is formed a hole (13) and at least one condensate outlet duct (8) leading to it, the film material of the bag being pierced in the area of the hole on each side of the condensate-removal member. In the heat exchanger, which has oppositely positioned bags (9) tied to form a pack, the condensate-removal members (9) are located one against another, and the apertures pierced in the film material form a condensate-collection duct common to them. The condensate-removal members being narrower than the bags enables the solid matter from the suspension being evaporated to be removed by falling through the spaces between the bottoms (10) of adjacent bags.
Patent DE-69834494-T2 (DE)
Inventor: KUENDIG THOMAS M
IPC: A61P31/04
Filed: 1998-07-10
Granted: 2007-03-01
Abstract: A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained period of time using, e.g., an osmotic pump. The method is advantageous over prior art methods for inducing a CTL response in that it does not require repetitive immunizations or the use of adjuvants. The method of the present invention can be used for the induction of CTLs in tumor or infectious disease immunotherapy.
Patent DE-69837477-T2 (DE)
Inventor: KRINGELUM BOERGE
IPC: C12N1/21
Filed: 1998-05-25
Granted: 2007-12-13
Abstract: Methods of enhancing the growth rate and/or controlling the metabolic activity of lactic acid bacteria and of improving the shelf life and/or the quality of an edible product using lactic acid bacterial organisms which are defective in their pyruvate metabolism. There is also provided starter culture compositions comprising such defective lactic acid bacteria as helper organisms and lactic acid bacterial starter culture strains. Useful helper organisms are Lactococcus strains which are defective with respect to pyruvate formate lyase (Pfl) and/or lactate dehydrogenase (Ldh) activity. The helper organisms may overexpress a gene coding for an NADH regenerating enzyme such as NADH oxidase encoded by nox gene.
Patent DE-69900291-T2 (DE)
Inventor: DENGHI PHILIPPE
IPC: A21C1/14
Filed: 1999-03-25
Granted: 2002-06-27
Abstract: The loaf of bread (1) is firmly attached to its baseplate (2), as dough was allowed to pass into openings in the plate before baking. This helps keep the loaf secure during slicing. The plate is held on a platform (4) which moves side-to-side and gradually rises as slices are taken off the top of the loaf by a saw.
Patent DE-69900690-T2 (DE)
Inventor: YVIN JEAN-CLAUDE
IPC: A61K35/08
Filed: 1999-07-05
Granted: 2002-09-12
Abstract: The present invention provides novel hypoosmotic saline compositions and their use as medicines for the prevention of the release of chemical mediators responsible for triggering phenomena causing inflammation of mucous membranes, and for the dissolution of cerumen plugs located in the external auditory meatus.
Patent DE-69906589-T2 (DE)
Inventor: ADRIANSENS ERIC
IPC: B67C3/00
Filed: 1999-12-07
Granted: 2003-12-24
Abstract: A flowback method for a product contained in the distribution circuit of a filling machine. The distribution circuit (22, 24, 26, 28, 30) creates an upstream/downstream link between a storage tank for said product and a filling tube (22) that is placed opposite the opening of a receptacle (12) that is to be filled. The method includes a step whereby a closed area around the filling tube (22) is defined by a sealed housing (38). The method further includes a step whereby a circulating liquid is injected into the above-mentioned area under pressure. The liquid passes through an auxiliary port (70), whereupon the product contained in the distribution method (22, 24, 26, 28, 30) flows back in the direction of the storage tank.
Patent DE-69908360-T2 (DE)
Inventor: PASSERA ANTHONY
IPC: G06N3/02
Filed: 1999-06-22
Granted: 2004-04-22
Abstract: The present invention provides a description of the behavior of a model that indicates the sensitivity of the model in subspaces of the input space and which indicates which dimensions of the input data are salient in subspaces of the input space. By implementing this description using a decision tree, the subspaces and their salient dimensions are both described and determined hierarchically. A sensitivity analysis is performed on the model to provide a sensitivity profile of the input space of the model according to sensitivity of outputs of the model to variations in data input to the model. The input space is divided into at least two subspaces according to the sensitivity profile. A sensitivity analysis is performed on the model to provide a sensitivity profile of each of the subspaces according to sensitivity of outputs of the model to variations in data input to the model.
Patent DE-69918414-T2 (DE)
Inventor: KWON JOONG-CHUN
IPC: C02F3/30
Filed: 1999-11-10
Granted: 2005-06-09
Abstract: The present invention provides a method and system for the treatment of wastewater. One embodiment includes an anaerobic reactor and aerobic reactor. A terminal settling tank includes an upflow anaerobic reactor comprising an inlet mounted at the external lowest region of the anaerobic reactor. An introducing mechanism is directly connected to the inlet and located at the lower region in the anaerobic reactor and has a perforated drain pipe therein. A mixer is provided at the main shaft. A discharge is provided for allowing reaction water, which contains some portion of sludge generate by the mixer, to flow into the aerobic reactor. A sludge-accumulator is provided for collecting the sludge, which is settled by gravity during the reaction and produced by the mixer, to the center of the anaerobic reactor.
Patent DE-69919661-T2 (DE)
Inventor: CLOOTS TOM
IPC: B32B7/02
Filed: 1999-10-27
Granted: 2005-09-22
Abstract: PROBLEM TO BE SOLVED: To provide a method for forming the layer of a conductive polymer without an additional annealing step at a high tamp., a water based composition for the same and a film having the conductive polymer layer. SOLUTION: The forming method includes a step for forming the conductive polymer layer on an object by preparing the water based composition containing a polythiophene, a poly anionic compound and a non-protonic compound having a dielectric constant (ε) of >=15, applying the composition on the object to form the layer and drying and during the formation, the object and the layer are kept at a temp. of 100 deg.C and the conductive polymer has 2 kΩ/(square) resistivity at most.
Patent DE-69920252-T2 (DE)
Inventor: HILER DOUGLAS
IPC: C07D487/08
Filed: 1999-11-09
Granted: 2005-09-29
Abstract: The present invention relates to a process for preparing a cross-bridged tetraaza macrocyclic ligands having formula (I), wherein each R is independently C1-C22 linear alkyl, C1-C22 branched alkyl, C7-C22 alkylenearyl, C8-C22 alkyl substituted alkylenearyl, and mixtures thereof; each index n is independently from 0 to 3, by contacting the a di-quaternary cis tetracycle precursor with as little as one equivalent of a borohydride reducing agent. The present process eliminates the need to use up to a twenty fold excess of reducing agent thereby further eliminating the need for work-up conditions which liberate significant amounts of hydrogen gas and which requires the disposal of large amounts of boron waste products.
Patent DE-69922627-T2 (DE)
Inventor: VERBOOM J
IPC: G11B20/14
Filed: 1999-06-10
Granted: 2005-11-03
Abstract: A method, circuit and system for selectively and adaptively effecting level conditioning of selected samples of a read signal in storage technologies. A circuit embodying the present invention includes sample logic, arithmetic logic and conditioning logic. The sample logic receives samples and provides a main sample and one or more selected neighbor samples. The arithmetic logic compares the main sample to the neighbor samples toward determining satisfaction of selected conditioning criteria. If the selected conditioning criteria are satisfied, the conditioning logic selectively and adaptively effects level conditioning as to the main sample. A method embodying the present invention comprises obtaining level conditioning parameters in association with a reference field of the read signal; sampling the read signal at channel bit locations to provide a plurality of samples; selecting a main sample from the plurality of samples; selecting one or more neighbor samples from the plurality of samples, the neighbor samples being disposed at predetermined distances, in channel bits, from the main sample; comparing the main sample to each of the neighbor samples to determine satisfaction of selected conditioning criteria; applying, where the selected conditioning criteria are determined to be satisfied, level conditioning to the main sample, such level conditioning being responsive to the level conditioning parameters.
Patent DE-69923715-T2 (DE)
Inventor: ROMASCHIN D
IPC: G01N33/576
Filed: 1999-11-30
Granted: 2006-01-05
Abstract: The invention relates to a method for measuring the level of a preselected analyte in a sample of blood of a human or animal patient by incubating the test sample with an antibody specific to the analyte to form an immunocomplex, which then interacts with the white blood cell fractions and result in the production of oxidants. Oxidants are detected using chemiluminescent reagents. The assay is performed on the sample and in addition includes a measurement of the oxidant production resulting from a maximal stimulatory dose of immunocomplexes, providing a ratio to indicate the level of analyte in the sample. The white blood cell oxidant response may be enhanced by the inclusion of certain agents such as zymosan. This method may be used to determine levels of analytes in a sample of a patient's blood including endotoxin and other analytes related to sepsis, in order to select the proper therapeutic course, or may be used to measure other analytes such as inflammatory mediators, hormones, acute phase proteins, toxins, drugs of abuse, markers of cardiac muscle damage, therapeutic drugs, cytokines, and chemokines. Additional parameters derived from the assay include maximul chemiluminscent response and responsiveness to aid in the staging of sepsis.