Patent SG-11201805888S-A (SG)
Title: Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
Inventor: GLICK GARY
IPC: C07H21/00
Filed: 2017-01-11
Abstract: RiA RIB L — X XZ X' X 4 X 6 —L 2 - R2A R —2B (A) R4' R4' 1 -^ 1 ^ , (iv) W O 20 17 / 123669 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/123669 Al 20 July 2017 (20.07.2017) WIPO I PCT 1111111111111101110111111111110101111101110111011101111111111111110111111111110111111 (51) International Patent Classification: C07H 21/00 (2006.01) A61P 35/00 (2006.01) A61K 31/7084 (2006.01) (21) International Application Number: PCT/US2017/013066 (22) International Filing Date: 11 January 2017 (11.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/277,273 11 January 2016 (11.01.2016) US 62/436,759 20 December 2016 (20.12.2016) US (72) Inventors; and (71) Applicants : GLICK, Gary [US/US]; 1663 Snowberry Ridge Rd., Ann Arbor, MI 48103 (US). GHOSH, Shomir [US/US]; 134 Sewall Avenue, Unit C, Brookline, MA 02446 (US). OLHAVA, Edward, James [US/US]; 11 Scarsdale Rd, Newton, MA 02460 (US). ROUSH, Willi- am, R. [US/US]; 1013 Town Hall Avenue, Jupiter, FL 33458 (US). JONES, Roger [US/US]; 65 Hillcrest Rd., Martinsville, NJ 08836 (US). (74) Agents: KENDALL, John, T. et al.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, MN 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [Continued on next page] (54) Title: CYCLIC DINUCLEOTIDES FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY SUCH AS CANCER (57) : This disclosure features dinucleotide com- pounds that modulate Stimulator of Interferon Genes (STING) activity, for use for example in the treatment of cancer. This disclosure also features compositions as well as other methods of using and making the same (Fomula (A)). A and B are each independently selected from the group consisting of Formulae (i), (ii), (iii), and (iv). R 5 0 R4 -- I ,1 Z2 Z 3 1 Z i R 6 Z 2 ' Z 2 R6 (i) (ii) WO 2017/123669 Al MIDEDIMOMMIONMEMOMEMODIEHHOMEHOIS TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Published: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, with international search report (Art. 21(3)) LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).