baber/WOPTO huggingface dataset:
Patent CA-3044896-A1 (CA)
Inventor: ALLERSON CHARLES R
IPC: A61K31/712
Filed: 2017-12-04
Abstract: La présente invention concerne des procédés pour le traitement de la polykystose rénale, comprenant la polykystose rénale autosomique dominante, au moyen d'oligonucléotides modifiés ciblés vers miR-17.
Patent CA-3048761-A1 (CA)
Inventor: STEINMETZER KATRIN
IPC: G01N33/543
Filed: 2017-12-22
Abstract: The present invention relates to a prefabricated microparticle for performing detection, preferably a digital detection and/or quantitation of an analyte. Furthermore, it also relates to a detection and/or quantitation of multiple analytes by prefabricated microparticles. It also relates to a collection of such prefabricated microparticles and to the use of such microparticle(s) and/or of such collection. Furthermore, the present invention also relates to a method of performing a detection and/or quantitation of an analyte in a sample wherein a microparticle or collection of microparticles are used. In one embodiment, in the collection of microparticles, individual microparticles are tailored for the detection of specific analytes and can be distinguished from each other by a specific label indicating the respective analyte for which the individual microparticle is specific.
Patent CA-3052188-A1 (CA)
Inventor: VAN DER MERWE SHAWN
IPC: C10G1/04
Filed: 2016-08-16
Abstract: A distributor for use in a tailings solvent recovery unit (TSRU), for example, can include slot-shaped pressure let-down apertures and a closed curved end portion to introduce the tailings into a separation vessel. The pressure let-down apertures can have different aperture surface areas sized in accordance with solids and solvent content of solvent diluted tailings exiting each pressure let-down aperture. The distributor construction can have various advantages, such as facilitating manufacturing as well as effective mitigation of pre-flashing and solids segregation issues.
Patent CA-3060105-A1 (CA)
Inventor: GUDKA BHAVIK
IPC: G06F9/44
Filed: 2019-10-24
Abstract: Disclosed are hardware and techniques for correcting computer process faults by identifying risk associated with correcting a computer process fault and computer processes that may depend on the corrected computer process. The interdependent computer processes in a network may be determined by evaluating a stream of process break flags from a monitoring component coupled to the network. Each computer process break flag in the stream of computer process break flags indicates a process fault detected by the monitoring component and is correlated to a corrective response. The break flag and the corrective response are assigned a risk. A risk matrix accounts for interdependencies between computer processes and identified corrective actions. A final response strategy that corrects the computer process faults is determined using the assigned risk and computer system interdependence. A runbook stores the final response strategy, which may be updated based on changing computer process interdependencies and assigned risk.
Patent CA-3061860-A1 (CA)
Inventor: ALONSO LIVIAN B
IPC: E21B7/00
Filed: 2019-11-18
Abstract: Embodiments disclosed herein generally relate to a method and a system to generate well trajectories. A computing device receives one or more parameters associated with a target well in a target location. The computing device receives two or more data points for the target well in the target location. The computing device generates a modified wellbore path based on the one or more parameters associated with a target well and the two or more data points via a trained wellbore prediction model. The computing device compares the modified wellbore path for the target well to one or more wellbore paths of one or more wells co-located with the target well in the target location. The computing device updates the modified wellbore path for the target well by adjusting one or more coordinates of the modified wellbore path based on the comparison. The computing device generates a three-dimensional model of the target location.
Patent CA-3063185-A1 (CA)
Title: Seed, soil, and plant treatment compositions
Inventor: JOHNSON EVAN
IPC: A01N37/44
Filed: 2018-05-15
Abstract: Embodiments of the present disclosure describe a seed, soil, or plant treatment composition comprising a nickel compound, an iron compound, and an optional molybdenum compound. Embodiments also describe a treatment composition comprising nickel lactate. Embodiments of the present disclosure further describe a method of preparing a seed, soil, or plant treatment composition comprising contacting a compound including nickel with a carboxylic acid to form a nickel chelated compound in solution, adding one or more of an iron compound and a molybdenum compound to the solution, and mixing the solution to form a seed, soil, or plant treatment composition.
Patent CA-3065791-A1 (CA)
Title: Surge arrester system and circuit breaker system
Inventor: Tschida Colin
IPC: H01H9/54
Filed: 2018-05-31
Abstract: A surge arrester system includes a surge arrester, and an active cooling system having a cooling interface in contact with the surge arrester and operative to transfer heat from the surge arrester. The active cooling system includes a forced convection apparatus operative to provide forced convection cooling. A circuit breaker system includes a power semiconductor switch and an active cooling system constructed to cool the power semiconductor switch. The active cooling system includes a forced convection apparatus configured to provide forced convection cooling. The power semiconductor switch is in contact with the active cooling system. A surge arrester is disposed adjacent to and in contact with the active cooling system. The active cooling system includes a cooling interface constructed for contact with the surge arrester and operative to provide cooling to the surge arrester. The power semiconductor switch and the surge arrester dissipate power alternatively.
Patent CA-3067160-A1 (CA)
Inventor: SHASHUA AMNON
IPC: G08G1/0968
Filed: 2016-02-10
Abstract: Systems and methods are provided for constructing, using, and updating the sparse map for autonomous vehicle navigation. In one implementation, a non-transitory computer-readable medium includes a sparse map for autonomous vehicle navigation along a road segment. The sparse map includes a polynomial representation of a target trajectory for the autonomous vehicle along the road segment and a plurality of predetermined landmarks associated with the road segment, wherein the plurality of predetermined landmarks are spaced apart by at least 50 meters. The sparse map has a data density of no more than 1 megabyte per kilometer.
Patent CA-3068938-A1 (CA)
Title: Plate-forme de criblage pour identifier des medicaments ou des agents therapeutiques pour le traitement de la maladie d'alzheimer
Inventor: TANZI RUDOLPH E
IPC: C07K16/28
Filed: 2018-01-18
Abstract: L'invention concerne des procédés et des compositions pour cribler des substances candidates pour la prévention ou le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer. L'invention concerne également l'identification des mécanismes d'action de médicaments connus ou suspectés contre la maladie d'Alzheimer et, de manière générale, des compositions et des procédés pour moduler la fonction de cellules exprimant CD33.
Patent CA-3070425-A1 (CA)
Title: In-line amplifier assembly for distributed sensing system
Inventor: LEBLANC MICHEL JOSEPH
IPC: E21B47/06
Filed: 2018-07-31
Abstract: The subject technology relates to an in-line amplifier assembly for distributed sensing system. The subject technology includes deploying a distributed sensing tool into a wellbore, and logging the wellbore using the distributed sensing tool. The distributed sensing tool includes a first optical amplifier and a first optical filter coupled to a first single-mode optical fiber. The first optical amplifier is coupled to a first single-mode circulator for amplifying a single-mode optical signal, and the first optical filter is coupled to the first optical amplifier for filtering the amplified single-mode optical signal. The first single-mode circulator is coupleable to an interrogator for routing the single-mode optical signal to a second single-mode optical fiber and routing a reflective optical signal from a second single-mode optical fiber to the interrogator. The reflective optical signal may traverse a second optical amplifier and a second optical fiber between the first and second single-mode circulators.
Patent CA-3074102-A1 (CA)
Title: Treatment of drug resistant gliomas
Inventor: TOWNER RHEAL A
IPC: A61K31/53
Filed: 2018-09-10
Abstract: The present disclosure describes the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4- ds-PBN) in the treatment of temozolomide drug resistant gliomas. The 2,4-ds-PBN may be used combined with other chemo- and radiotherapies and surgery, including temozolomide, to reduce glioma occurrence, recurrence, spread, growth, metastasis, and vascularization, and to inhibit development of temozolomide resistance.
Patent CA-3074741-A1 (CA)
Title: Structural equipment load monitoring system and method
Inventor: D'ELIA GREGORY
IPC: G01L1/22
Filed: 2019-07-25
Abstract: A system for monitoring loading of equipment includes a transmitter assembly mounted to the equipment and a central server. The transmitter assembly has a strain gauge secured to the equipment, an on-board controller and a battery. The central server is in communication with the on-board controller. The central server is configured to receive collected loading data from the transmitter assembly. The on-board controller is configured to operate the transmitter assembly in a load monitoring power mode and a deep sleep mode. The on-board controller is configured to operate at a sleep interval when a load measured by the strain gauge is less than ten percent of a rated working load of the equipment and at an active interval when the load measured by the strain gauge is greater than ten percent of the rated working load. The sleep interval is less than the active interval.
Patent CA-3075376-A1 (CA)
Inventor: LIU JIEYING
IPC: C07K16/28
Filed: 2018-09-20
Abstract: L'invention concerne un complexe polypeptidique anti-CD3 x CD19 bispécifique qui contient une première fraction de liaison à l'antigène du complexe polypeptidique et une seconde fraction de liaison à l'antigène, des procédés de production du complexe polypeptidique anti-CD3 x CD19 bispécifique, des méthodes de traitement d'une maladie ou d'un trouble à l'aide du complexe polypeptidique anti-CD3 x CD19 bispécifique, des polynucléotides codant pour le complexe polypeptidique anti-CD3 x CD19 bispécifique, des vecteurs et des cellules hôtes contenant lesdits polynucléotides, ainsi que des compositions et des compositions pharmaceutiques comprenant le complexe polypeptidique anti-CD3 x CD19 bispécifique.
Patent CA-3075672-A1 (CA)
Inventor: ANDERSON MARTIN L
IPC: E04G23/00
Filed: 2018-10-04
Abstract: A walk-behind floor scraper machine for removing floor covering from a floor surface is disclosed. In one aspect, the machine includes a base frame, an electric motor secured to the base frame, and a scraper assembly movably secured to the base frame and driven by the electric motor. The machine also includes a rear wheel arrangement including a pair of wheels having a rotational axis. In one aspect, the machine includes a hydraulic circuit with a hydraulic pump driven by the electric motor and a hydraulic motor powered by the hydraulic pump. The hydraulic motor has a drive axle coupled to the wheels, wherein the drive axle is coaxially aligned with the rotational axis. In one aspect, the machine can include a hydraulic tank- frame integral to the chassis of the machine that simultaneously stores hydraulic fluid and structurally supports the hydraulic motor.
Patent CA-3078465-A1 (CA)
Title: Methods and compositions relating to anti-chi3l1 antibody reagents
Inventor: ELIAS JACK A
IPC: C07K19/00
Filed: 2018-08-23
Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.
Patent CA-3078611-A1 (CA)
Title: Systems and methods for privacy preserving accurate analysis of network paths
Inventor: NICOL DAVID M
IPC: G06F21/60
Filed: 2018-10-15
Abstract: Anonymizing systems and methods comprising a native configurations database including a set of configurations, a key management database including a plurality of private keys, a processor in communication with the native configurations database and the key management database, and a memory coupled to the processor. The set of configurations includes one or more ranges, wherein each range includes a contiguous sequence comprised of IP addresses, port numbers, or IP addresses and port numbers. The processor is configured to retrieve the set of configurations from the native configurations database, wherein the set of configurations includes a plurality of objects; retrieve a private key from the key management database; assign a unique cryptographically secure identity to each object; and anonymize the plurality of objects based on the cryptographically secure identities and the private key.
Patent CA-3079060-A1 (CA)
Title: Substituted pyrrolopyridine-derivatives as map4k1 modulators for the treatment of cancer diseases
Inventor: SCHMEES NORBERT
IPC: A61K31/437
Filed: 2018-06-07
Abstract: The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which X, Y, R1, R2a, R2b, R3 and R4 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.
Patent CA-3083331-A1 (CA)
Inventor: GIOVANNINI RICCARDO
IPC: C07D471/04
Filed: 2018-12-06
Abstract: La présente invention concerne de nouveaux imidazopyridines de formule générale A, leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie, en particulier dans le traitement ou la prévention d'affections associées à des propriétés de modulation allostériques négatives de NR2B.
Patent CA-3084920-A1 (CA)
Inventor: SKOG JOHAN KARL OLOV
IPC: C12Q1/6806
Filed: 2015-07-09
Abstract: Abrégé : Il est décrit de nouveaux procédés et kits pour isoler des acides nucléiques à partir déchantillons biologiques, y compris lADN sans cellules et/ou lADN et acides nucléiques sans cellules comprenant au moins lARN de microvésicules, et pour extraire des acides nucléiques à partir de ces microvésicules et/ou des échantillons biologiques. Date reçue / Date Received 2020-06-25
Patent CA-3085678-A1 (CA)
Title: Outil de criblage pour les affections pulmonaires de patients
Inventor: DE BACKER JAN
IPC: A61B5/087
Filed: 2018-12-14
Abstract: La présente invention concerne le domaine des techniques de criblage pour les affections pulmonaires. En particulier, la présente invention fournit des systèmes et des procédés de criblage d'un sujet vis-à-vis de la présence d'affections pulmonaires. Un système comprend une unité capteur configurée pour enregistrer une expansion d'un thorax d'un sujet, le système étant configuré pour déterminer à partir des données émises par l'unité capteur une expansion locale du thorax et une distribution de l'écoulement d'air interne des poumons du sujet.
Patent CA-3085994-A1 (CA)
Title: Method of treatment of diabetic foot ulcers
Inventor: PALACIO BARBERAN JOHN LUIS
IPC: A61K31/194
Filed: 2018-10-02
Abstract: A novel method of treating, preventing and maintaining diabetic foot ulcers is described.
Patent CA-3086092-A1 (CA)
Title: Novel galactoside inhibitor of galectins
Inventor: ZETTERBERG FREDRIK
IPC: A61P35/00
Filed: 2019-01-09
Abstract: The present invention relates to a compound of the general formula (I) wherein the pyranose ring is a-D-galactopyranose, R1 is selected from the group consisting of (II) wherein the asterix 1 * indicates the carbon atom of the heteroaromatic ring that is covalently attached to the triazole group of formula (I). The compound of formula (I) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal, such as a human.
Patent CA-3086890-A1 (CA)
Inventor: MEYER ADAM
IPC: A61M16/20
Filed: 2019-01-03
Abstract: La présente invention concerne un système à pression expiratoire positive oscillante comprenant un dispositif à pression expiratoire positive oscillante, un adaptateur accouplé au dispositif, et un module de commande accouplé à l'adaptateur. Le module de commande fournit des informations en temps réel concernant l'utilisation du dispositif, et fournit une rétroaction et un stockage des informations pour améliorer leur utilisation.
Patent CA-3087518-A1 (CA)
Title: Process and method for reducing metal corrosion in water
Inventor: XIE YANJIAO
IPC: C07D235/12
Filed: 2018-12-28
Abstract: This disclosure relates to compositions and methods of reducing corrosion using benzimidazoles. The method may include adding a benzimidazole and a halogen to an aqueous system that is in contact with a metal surface. The halogen may be bromine, iodine, or any combination thereof. In some cases, adding the halogen may be optional depending on the substituents on the benzimidazole ring. Compositions are also disclosed that include a benzimidazole, optionally a halogen depending on the substituents on the benzimidazole ring, and optionally a halogen stabilizer.
Patent CA-3089785-A1 (CA)
Inventor: DECOCK THIERRY
IPC: A61M15/08
Filed: 2019-02-05
Abstract: The invention relates to a method for monitoring the dispensing of a drop by a device for dispensing a liquid product in the form of drops, using means for detecting a liquid product which are arranged near an orifice for dispensing drops, and a system (40) for processing information provided by the detection means, a monitoring method during which the processing system (40) receives information corresponding to the following series of steps: - a step of detecting the presence of liquid, during which the detection means detect the presence of liquid near the dispensing orifice, the detection means being configured such that the detection of the presence of liquid is indicative of a drop in the course of being formed, in contact with the dispensing orifice, - a step of detecting an absence of liquid, during which the detection means detect the absence of liquid near the dispensing orifice, and the processing system (40) processes the series of information on detection of the presence and absence of liquid in order to provide a piece of information on the dispensing of a drop. The invention also relates to a device (10) assisting the use of a device for dispensing a liquid product in the form of drops.
Patent CA-3090304-A1 (CA)
Title: Antisense modulation of interleukins 17 and 23 signaling
Inventor: SCHNELL FREDERICK J
IPC: C12N15/63
Filed: 2011-05-13
Abstract: ABSTRACT Provided are antisense oligonucleotides and other agents that target and modulate IL-17 and/or IL-23 signaling activity in a cell, compositions that comprise the same, and methods of use thereof. Also provided are animal models for identifying agents that modulate 17 and/or IL-23 signaling activity. Date Recue/Date Received 2020-08-18
Patent CA-3090651-A1 (CA)
Title: A surface panel connection system
Inventor: KELLY GREGORY JOHN
IPC: F16B21/06
Filed: 2019-02-08
Abstract: Embodiments of the present invention provide a connection system with a projection on a first connector and a co-operating cavity on a second connector to provide push-through connection of the connectors in first and second configurations in which the projection extends to first and second depths respectively within the cavity, wherein one or more of the projection or cavity is movable in two dimensions perpendicular to a longitudinal axis of the projection when received in the cavity, wherein the first and second connectors have cooperating locking surfaces arranged to engage each other when the projection is received at the second depth to prevent said movement in two dimensions and wherein the cooperating locking surfaces do not engage each other so as to prevent said movement in two dimensions when the projection is received at the first depth in the receiving cavity.
Patent CA-3092909-A1 (CA)
Inventor: MOLONEY PATRICK
IPC: A24F40/65
Filed: 2019-02-12
Abstract: La présente invention concerne un système électronique de fourniture de vapeur comprenant un vaporisateur pour vaporiser une charge utile à inhaler par un utilisateur du système électronique de fourniture de vapeur, une durée finie s'écoulant entre la fourniture d'énergie au vaporisateur et la vaporisation de la charge utile par ce dernier ; une alimentation électrique pour fournir de l'énergie au vaporisateur pour vaporiser la charge utile en réponse à une activation par l'utilisateur ; un ou plusieurs capteurs permettant de délivrer des signaux respectifs en réponse à une interaction de l'utilisateur avec le système électronique de fourniture de vapeur ; un processeur d'estimation conçu pour estimer le moment d'activation par l'utilisateur attendu, sur la base de l'analyse d'un ou de plusieurs des signaux respectifs ; et un processeur de commande conçu pour faire en sorte que de l'énergie soit fournie au vaporisateur à un moment qui précède le moment d'activation par l'utilisateur attendu estimé.
Patent CA-3095101-A1 (CA)
Inventor: LI PENG
IPC: A61K31/4985
Filed: 2019-03-22
Abstract: L'invention concerne des composés gamma-carbolines fusionnés à hétérocycles deutérés substitués particuliers, leurs promédicaments, sous forme de sel libre, solide, pharmaceutiquement acceptable et/ou sous une forme sensiblement pure, des compositions pharmaceutiques contenant ces composés, ainsi que leurs méthodes d'utilisation dans le traitement de maladies impliquant le récepteur 5-HT2A, le transporteur de la sérotonine (SERT) et/ou des voies impliquant des systèmes de signalisation des récepteurs D1/D2 de la dopamine, et/ou le traitement de symptômes résiduels.
Patent CA-3099310-A1 (CA)
Title: Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity
Inventor: YUAN JINFANG
IPC: A61K8/19
Filed: 2018-05-28
Abstract: Oral care composition for increasing deposition efficacy of a cooling sensate agent in the oral cavity. The oral care composition is made up of water and a calcium-containing abrasive to form a calcium-containing abrasive based carrier, and a cooling sensate agent comprising a N-substituted p-menthanecarboxamide containing compound.