baber/WOPTO huggingface dataset:
Patent DE-69417589-T2 (DE)
Inventor: BROSE DANIEL J
IPC: C07C45/79
Filed: 1994-03-16
Granted: 1999-07-15
Abstract: The sepn. of the enantiomers of 4-(3,4-dichlorophenyl) -3,4-dihydro-1(2H) -naphthalenone (I) comprises (a) contacting the enantiomers with a liq. mixt. of water and a solvent, this liq. contg. a substantially pure and unsupported binding substance (II) chosen from gamma-cyclodextrin, anionic poly-gamma-cyclodextrin, (2-hydroxypropyl) -gamma-cyclodextrin, gamma-cyclodextrin -phosphate sodium salt, succinylated gamma-cyclodextrin, octabis(2,3,6-tri-O -acetyl)-gamma-cyclodextrin and carboxymethyl -gamma-cyclodextrin, thus selectively binding one of the enantiomers to (II); and (h) sepg. (II) from the liq. mixt.. The enantiomers are soluble in the liq. mixt. to at least 1.0 mM and the solvent is chosen from alkanes, halogenated alkanes, alkenes, alcohols, ketones, nitriles, ethers, and/or esters and in chosen so that (II) is substantially insol. in the liq. mixt.
Patent DE-69423342-T2 (DE)
Inventor: HEIBER J
IPC: A61K47/28
Filed: 1994-02-03
Granted: 2000-10-12
Abstract: A method and system for mucosally administering a macromolecular drug to mucosa of the oral cavity is shown. The system comprises an inner drug/enhancer/polymer layer having one surface adapted to contact and adhere to the mucosal tissue of the oral cavity and an opposing surface in contact with and adhering to an overlying inert layer. The inner layer contains from about two to sixty percent by weight of a bile salt enhancer, five to sixty five percent by weight of a hydrophilic polymer which is water soluble or swellable and an effective amount of a macromolecular drug having a molecular weight of at least 500 daltons. Polysaccharides, polypeptides and proteins are preferred forms of macromolecular drugs. The bile salt enhancer facilitates the delivery of macromolecules such as low molecular weight heparin and calcitonin. The polymer serves as a plasticizer to prevent the crystallization and/or aggregation of such macromolecular drugs. Hydroxypropyl cellulose is a particularly suitable polymer.
Patent DE-69428120-T2 (DE)
Inventor: WILLIAMS PATRICIA B
IPC: A61K9/00
Filed: 1994-04-25
Granted: 2002-04-11
Abstract: Persistent epithelial defects are effectively treated by topically applying a gelatinous composition containing either aminocaproic acid or tranexamic acid to the eye. In vivo results demonstrate improved healing of the epithelium and basement membrane complex. The gelatinous composition is prepared by a process that ensures sterility and proper pH conditions throughout the gel.
Patent DE-69430799-T2 (DE)
Inventor: SCHLIPALIUS LANCE ELLIOTT
IPC: A61K31/07
Filed: 1994-03-22
Granted: 2003-02-13
Abstract: PCT No. PCT/AU94/00143 Sec. 371 Date Sep. 22, 1995 Sec. 102(e) Date Sep. 22, 1995 PCT Filed Mar. 22, 1994 PCT Pub. No. WO94/21232 PCT Pub. Date Sep. 29, 1995The invention is a carotenoid agent for inhibiting the conversion of epithelial cells to tumours, the agent including an effective amount of a water insoluble carotenoid component in a suitable non-toxic carrier medium.
Patent DE-69503964-T2 (DE)
Inventor: EKBERG BJARNE
IPC: B01D24/46
Filed: 1995-04-18
Granted: 1999-03-11
Abstract: The invention relates to a method and apparatus for cleaning the filter medium in a suction dryer by means of ultrasound in an essentially continuous operation. According to the invention, the ultrasonic beams emitted from at least one ultrasonic oscillator (1, 12, 22) are focused essentially near to the filter surface (4, 14, 25) of the filter medium, advantageously on the filter surface (4, 14, 25) of the filter medium, in order to create at least one ultrasound focusing zone. <IMAGE>
Patent DE-69506671-T2 (DE)
Inventor: CERRI ALBERTO
IPC: C07C281/20
Filed: 1995-10-27
Granted: 1999-05-27
Abstract: 1,5-disubstituted 7a-methylperhydroinden-3a-ol derivatives having general formula (I): <CHEM> wherein the symbol -------- represents a single or a double bond, the symbol  @ represents a Z or E configuration, A and L have the meanings given in the description; processes for producing same and their use for the preparation of a medicament for the treatment of cardiovascular disorders, such as heart failure and hypertension are disclosed.
Patent DE-69507639-T2 (DE)
Inventor: ANTANE MADELENE
IPC: A61P15/00
Filed: 1995-10-03
Granted: 1999-09-02
Abstract: The compound of formula (I), wherein R1 and R2 are, independent from each other, hydrogen, C1-10 straight chain alkyl, C1-10 branched alkyl, or C3-10 cyclic or bicyclic alkyl; R3 is an acyl substituent selected from the group consisting of formyl, alkanoyl of 2 to 7 carbon atoms, alkenoyl of 3 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms; A is selected from the group consisting of (a), wherein R4 is hydrogen, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-6 alkylamino, C2-12 dialkylamino, C1-6 alkylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, nitro, cyano, carboxyl; or, A is a phenyl group of formula (b), wherein R5 and R6, independent from each other, are selected from the following: cyano, nitro, amino, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, C1-6 alkylamino, C2-12 dialkylamino, sulfamyl, C1-6 alkylsulfonamido, C6-12 arylsulfonamido, alkylcarboxamido containing 2 to 7 carbon atoms, arylcarboxamido containing 7 to 13 carbon atoms, C2 to C6 alkanoyl, C1-6 alkylsulfonyl, C1-6 perfluoroalkylsulfonyl, C6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.
Patent DE-69508742-T2 (DE)
Inventor: MUNACHEN RICHARD NASH
IPC: A47B88/493
Filed: 1995-01-24
Granted: 1999-09-16
Abstract: PCT No. PCT/GB95/00133 Sec. 371 Date Sep. 19, 1996 Sec. 102(e) Date Sep. 19, 1996 PCT Filed Jan. 24, 1995 PCT Pub. No. WO95/19724 PCT Pub. Date Jul. 27, 1995A drawer slide formed by cold rolling metal strip and shaped, in cross section, to define first mutually presented tracks for receiving and cooperating with a first set of rollers carried, in use, by a drawer, second mutually presented tracks for receiving and cooperating with rollers carried in use by the drawer receiving cabinet, a first web portion integrally interconnecting the first tracks, a second web portion integrally interconnecting the second tracks, an integral stop closing both ends respectively of a first channel defined by one of the first and second webs and its respective tracks, a cut-out adjacent one end of the outer track of the first channel to facilitate insertion of the respective rollers into the first channel, an integral stop closing the end of a second channel by the other of the first and second webs and the respective tracks, remote from the end of the slide having the cut-out, and an access aperture in the web portion of the second channel providing in use, access through the web portion to a device for securing the respective rollers to the drawer or to the cabinet carcass.
Patent DE-69519106-T2 (DE)
Inventor: PAREN AARTO
IPC: A61L15/20
Filed: 1995-03-09
Granted: 2001-05-23
Abstract: A fibrous structure contains urea peroxide absorbed therein. The fibre is polysilicic acid containing fibre, the supporting structure of which is regenerated viscose cellulose in which the polysilicic acid is homogeneously distributed in the same phase.
Patent DE-69528064-T2 (DE)
Inventor: DEFEO-JONES DEBORAH
IPC: A61K47/48
Filed: 1995-06-07
Granted: 2003-08-07
Abstract: Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
Patent DE-69528239-T2 (DE)
Inventor: VIANELLO FORTUNATO
IPC: E06B3/673
Filed: 1995-10-25
Granted: 2003-05-08
Abstract: An automatic method and device for calendering aluminum profiles for producing spacer frames for insulating glazing units, the method consisting in producing calendering by preliminarily deforming the surface (3) on which minute holes (4) are formed so as to obtain an inside curve (7). A consecutive plurality of minute bends, the pitch increment whereof tends to zero and the bending angle increment whereof tends to zero, is then performed at an automatically controlled microbending station (9). <IMAGE>
Patent DE-69530832-T2 (DE)
Inventor: FOTINOS SPIROS
IPC: A61K31/565
Filed: 1995-07-25
Granted: 2004-04-22
Abstract: PCT No. PCT/EP95/02938 Sec. 371 Date Jun. 19, 1996 Sec. 102(e) Date Jun. 19, 1996 PCT Filed Jul. 25, 1995 PCT Pub. No. WO96/03119 PCT Pub. Date Feb. 8, 1996A composition for use in a three layer transdermal delivery system is disclosed, the composition comprising an adhesive matrix having sufficient strength to maintain an association on the skin for at least 3 days. The adhesive matrix contains the flux enhancer linoleic acid, an anti-oxidant and an effective dose of one or more steroid hormones with female sex related activity.
Patent DE-69601535-T2 (DE)
Inventor: CORNARO VITTORIO FEDERICO
IPC: A01G1/00
Filed: 1996-04-09
Granted: 1999-09-16
Abstract: A composition for a nutritive layer for grass sward is described, comprising, in percentage by volume, from 40 to 80 % of volcanic gravel and from 0.8 to 60 % of green vegetable compost. The composition preferably also contains up to 15 % by volume of pumice in the form of granules and 2 10<-3> % - 3 10<-3> % by volume of bone meal. A method for making grass sward using the above described composition is also described.
Patent DE-69603138-T2 (DE)
Inventor: CANZIANI FRANCESCO
IPC: B65G59/00
Filed: 1996-09-25
Granted: 1999-10-28
Abstract: A destacker for small flat packages such as audio or video cassettes includes a gripper for gripping a vertically oriented package of a horizontal stack of such packages, and transferring the package to a releasing location while simultaneously repositioning the package into a horizontal orientation. The gripper is mounted to a pair of pivoted links. An actuator causes the links to rotate such that the gripper is transferred while being initially rotated in a first direction and finally being rotated in an opposite direction. <IMAGE>
Patent DE-69605556-T2 (DE)
Inventor: DMITRI PTCHELINTSEV
IPC: A61P17/00
Filed: 1996-05-14
Granted: 2000-06-15
Abstract: This disclosure relates to a novel derivative of L-ascorbic acid which is stable, easily incorporated into cosmetically acceptable vehicles and enzymatically bioreversible in the skin to free ascorbic acid and a safe cholesterol component. An exemplary embodiment is 3'-(L-ascorbyl-2-phosphoryl)-cholesterol which is shown in Formula (I).
Patent DE-69606982-T2 (DE)
Inventor: CHINH JEAN-CLAUDE
IPC: C08F10/00
Filed: 1996-12-23
Granted: 2000-06-29
Abstract: The present invention relates to a start-up process of a continuous gas fluidised bed process for the polymerisation of olefin monomer selected from (a) ethylene, (b) propylene, (c) mixtures of ethylene and propylene, and (d) one or more other alpha-olefins mixed with (a), (b) or (c), in a fluidised bed reactor by continuously recycling a gaseous stream comprising at least some of the ethylene and/or propylene through a fluidised bed in said reactor in the presence of a polymerisation catalyst under reactive conditions, cooling at least part of said gaseous stream withdrawn from said reactor to a temperature at which liquid condenses out, separating at least part of the condensed liquid from the gaseous stream, and introducing at least part of the separated liquid directly into the fluidised bed using a liquid injection means, characterised in that at least part of the gaseous recycle stream by-passes the hereabove cooling/condensing/separating steps, and is reintroduced as the recycling gaseous stream passing through the reactor.
Patent DE-69608124-T2 (DE)
Inventor: MOHAT WILLIAM D
IPC: G06F11/16
Filed: 1996-12-12
Granted: 2001-04-26
Abstract: A dual processor computer system with error checking that stops immediately when a discrepancy is detected between the two processors. The system includes a first processor for executing a series of instructions including input/output instructions. A second processor executes the same instructions independently of and in synchronization with the first processor. Both processors have a processor independent bus interface. All significant processor address, data, and control signals are connected to all peripheral devices by a processor independent I/O bus. A comparison circuit detects discrepancies in the operation of the two lock step processors and provides a signal that immediately stops operation of the processors when an error is detected. Each processor is connected through its associated processor independent bus interface to the comparison circuit and the first processor is also connected through its interface to the I/O bus. The I/O bus is independent of the processor type, clock rate, and peripherals chosen in the construction of the computing system. This independence allows the computing system to be upgraded with faster processors and newer peripherals, without having to redesign the error checking circuitry.
Patent DE-69614258-T2 (DE)
Inventor: SVEDMAN PAAL
IPC: A61B17/30
Filed: 1996-04-24
Granted: 2002-06-13
Abstract: There is disclosed an apparatus (1) for use in a suction blister technique of sampling fluid from the human or animal body. The apparatus (1) comprises a cup (2) defining a chamber and having a rim portion (3) defining an aperture (5) communicating with the chamber. An annular flange (6) extends outwardly from the rim portion (3) whereby in use the flange (6) is sealingly attached to the body such that an area of skin closes the aperture (5). A ducted portion (11) is connected to the cup (2) and defines duct (12) which communicates with the chamber. The cup (2) further comprises a roof (4) which merges with the rim portion (3) and is formed of a resiliently deformable material having a shape memory which urges the roof (4) into an expanded configuration in which the roof (4) is held clear of the aperture (5). The roof is however deformable to a collapsed configuration in which it is proximal to the aperture (5).
Patent DE-69615685-T2 (DE)
Inventor: CHERMANN JEAN-CLAUDE
IPC: A61K35/76
Filed: 1996-06-28
Granted: 2002-08-08
Abstract: PCT No. PCT/FR96/01006 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Jun. 28, 1996 PCT Pub. No. WO97/02344 PCT Pub. Date Jan. 23, 1997An immunogenic composition for treating and/or preventing infectious diseases where the infectious agent has at least one intracellular phase in the host during its multiplication cycle, is disclosed. The immunogenic composition comprises at least one cryptic epitope of a cellular element that is carried along by an intracellular infectious agent as it leaves the cell, and revealed by said infectious agent. A composition for treating and/or preventing HIV infections, antibodies to a peptide of interest, and a diagnostic method, are also disclosed.
Patent DE-69616556-T2 (DE)
Inventor: MURPHY S
IPC: B32B7/02
Filed: 1996-05-24
Granted: 2002-07-11
Abstract: A laminated tape/bandage comprising a layer of transversely-spaced, longitudinally-extending elastic strands between a pair of outer layers, at least one of which is a warp-knitted (weft insertion) fabric oriented with the knit yarns extending longitudinally and generally parallel to the orientation of the elastic strands.
Patent DE-69622991-T2 (DE)
Inventor: POPLI DASS
IPC: A61K9/00
Filed: 1996-01-16
Granted: 2003-04-10
Abstract: There is provided a pharmaceutically acceptable taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of polyethylene glycol and cellulosic material.
Patent DE-69624004-T2 (DE)
Inventor: BILLIET ERIK
IPC: A61B5/0215
Filed: 1996-04-15
Granted: 2003-04-17
Abstract: PCT No. PCT/BE96/00043 Sec. 371 Date Oct. 10, 1997 Sec. 102(e) Date Oct. 10, 1997 PCT Filed Apr. 15, 1996 PCT Pub. No. WO96/32056 PCT Pub. Date Oct. 17, 1996An apparatus is in development which measures the blood outflow through the heart valves by means of the bolus thermodilution method and which from then on measures the continuous cardiac output, considering the formula of Gorlin and the measurement of the blood pressure in the compartments of the heart.
Patent DE-69635732-T2 (DE)
Inventor: ZAMORA O
IPC: A61K38/00
Filed: 1996-05-22
Granted: 2006-11-02
Abstract: The invention relates to radiotherapy with somatostatin-derived peptides labeled with medically useful metal ions. The invention in particular provides for methods and reagents for labeling somatostatin-derived peptides with perrhenate, in which a solution including somatostatin-derived peptide analogue containing at least one disulfide bond is provided, the solution is reacted with stannous ions and with a radioisotope, wherein the stannous ions are sufficient to substantially reduce the disulfide bonds of the peptide and the radioisotope, and the radiolabeled somatostatin-derived peptide analogue recovered. Also provided are methods for regional administration of radiolabeled somatostatin-derived peptides, methods for enhanced regional retention of radiolabeled somatostatin-derived peptides, methods for treatment of arthritis using radiolabeled somatostatin derived peptides, and methods for stabilizing radiolabeled somatostatin derived peptides.
Patent DE-69700361-T2 (DE)
Inventor: NORDMAN ERIC
IPC: G01N27/447
Filed: 1997-11-11
Granted: 2000-02-03
Abstract: An electrophoresis system including means for reducing the distortion of a sample zone eluting from a capillary electrophoresis separation capillary is disclosed. The system includes one or more separation capillaries, each separation capillary having an inlet end and an outlet end; a first electrode in electrical communication with the inlet ends of the separation capillaries; a second electrode in electrical communication with the outlet ends of the separation capillaries; and one or more focusing electrodes in electrical communication with the outlet ends of the separation capillaries. In operation, the voltage of each of the electrodes is adjusted such that (i) the sample zone is transported from the inlet end to the outlet end of the separation capillaries and (ii) the distortion of the sample zone eluting from the separation capillaries is reduced.
Patent DE-69701981-T2 (DE)
Inventor: VAN VLIET HENDRIK
IPC: D04H3/011
Filed: 1997-06-10
Granted: 2000-10-12
Abstract: The invention pertains to a grid comprising drawn polymeric strips (1, 2) in at least two different directions, with the strips being bonded together in the zone or zones of overlap (3), wherein the said zone comprises at least two spatially separated bonding points or lines. The grids according to the invention exhibit improved strength and can be manufactured in a very efficient manner.
Patent DE-69711065-T2 (DE)
Inventor: FOWLER JOHN
IPC: A61Q1/02
Filed: 1997-10-08
Granted: 2002-11-07
Abstract: The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and conditioning the skin or hair. These products are used by the consumer by wetting the dry product with water. The product comprises of a water insoluble substrate, a lathering surfactant, and a conditioner component. The invention also encompasses methods for cleansing and conditioning the skin or hair using these products and to methods for manufacturing these products.
Patent DE-69712203-T2 (DE)
Inventor: MITCHELL GEORGE WALLACE
IPC: B62D13/04
Filed: 1997-07-24
Granted: 2002-12-19
Abstract: A multiple axle trailer is disclosed consisting of a main chassis articulated to a tractor unit and a sub-chassis relative to which the main chassis rotates on a turntable. The sub-chassis has a pair of forward wheel (3) and pair of rear wheels (4), each of which rotates on a stub axle and king pin assembly (6). A steering mounting has two swinging arms depending from the main chassis, joined at their free ends by a horizontal tie. A primary link of a linkage mechanism is coupled to the horizontal tie, the linkage mechanism coupling the wheels to the steering mounting such that rotation of the main chassis relative to the sub-chassis causes the stub axles to pivot about the king pins. Movement of the swinging arms causes the line of action of the primary link to cross the axis about which the main chassis rotates relative to the sub-chassis, reversing the direction of steer for when the trailer is backed up.
Patent DE-69717247-T2 (DE)
Inventor: BONETTI MASSIMO
IPC: E05D15/10
Filed: 1997-03-12
Granted: 2003-07-24
Abstract: A system for opening and closing at least one door (20) in furniture, rooms and the like, involves the use of a vertical rod (24) from which arms (36, 37) extend that engage slidingly with the door (20), the bottom of the door (20) being fitted with wheels (52A, 52B) so that, in order to open the door and by rotating the arms (36, 37), the door (20) is moved from the closed position into a position in which it is displaced outwards. The door (20) is then slid back over the arms (36, 37) until the opened position is reached. This door opening and closing system does not require any space in front of the door and, in cases where there are multiple doors, allows one door to be in perfect alignment with another door. Furthermore, it is both structurally simple and easy to operate. <IMAGE>
Patent DE-69726674-T2 (DE)
Inventor: POULETTY PHILIPPE
IPC: A61K38/20
Filed: 1997-04-09
Granted: 2004-10-21
Abstract: Novel conjugates are provided comprising a moiety capable of specifically binding to a target cell joined to a selective moiety for binding to an endogenous effector agent, capable of causing cell inactivation or cytotoxicity. Example of conjugates are a ligand for a surface membrane protein, e.g. IL-2 receptor, joined to an alpha-galactosyl epitope, or a polysaccharide A or B antigen. The conjugates may be used to specifically destroy cells associated with a pathogenic condition.
Patent DE-69735995-T2 (DE)
Inventor: SCHLOM JEFFREY
IPC: C12Q1/68
Filed: 1997-03-19
Granted: 2007-04-19
Abstract: The invention provides a prostate specific antigen oligo-epitope peptide (PSA-OP) that is useful as an immunogen in the prevention or treatment of prostatic cancer and in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines. In particular, the invention provides methods for eliciting an immune response against PSA comprising administering (i) a priming inoculation of a first recombinant virus encoding PSA-OP and (ii) one or more boosting inoculations of a second recombinant virus encoding PSA-OP, wherein the first and second recombinant viruses are from a different genus.
Patent DE-69736777-T2 (DE)
Inventor: SOLL M
IPC: C07C323/66
Filed: 1997-03-27
Granted: 2007-08-23
Abstract: Amidino and benzamidino compounds, including compounds of the formula:    <IMAGE>  I  wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.