baber/WOPTO huggingface dataset:
Patent NZ-606848-A (NZ)
Title: 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta-secretase (bace)
Inventor: TRABANCO-SUÁREZ ANDRÉS AVELINO
IPC: A61K31/4162
Filed: 2011-09-20
Abstract: Disclosed are N-{ 3-[6-amino-4-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl]-phenyl} -benzamide derivatives as represented by the general formula (I), or a tautomer or a stereoisomeric form thereof, wherein R1 and R2 are independently selected from the group consisting of hydrogen, fluoro, cyano, alkyl, mono- and polyhalo-alkyl, and cycloalkyl; or R1 and R2 taken together with the carbon atom to which they are attached may form a cycloalkanediyl ring; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, mono- and polyhalo-alkyl, homoaryl and heteroaryl; X1, X2, X3, X4 are independently C(R4) or N, provided that no more than two thereof represent N; each R4 is selected from the group consisting of hydrogen, halo, alkyl, mono- and polyhalo-alkyl, cyano, alkyloxy, mono- and polyhalo-alkyloxy; L is a bond or -N(R5)CO-, wherein R5 is hydrogen or alkyl; R6 is hydrogen or trifluoromethyl; Ar is homoaryl or heteroaryl; homoaryl is phenyl or phenyl substituted with one, two or three substituents selected from the group consisting of halo, cyano, alkyl, alkyloxy, mono and polyhalo-alkyl; and mono- and polyhalo-alkyloxy; heteroaryl is selected from the group consisting of pyridyl, pyrimidyl, pyrazyl, pyridazyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, thiadiazolyl, oxazolyl, and oxadiazolyl, each optionally substituted with one, two or three substituents selected from the group consisting of halo, cyano, alkyl, alkyloxy, mono- and polyhalo-alkyl; and mono- and polyhalo-alkyloxy; or an addition salt or a solvate thereof. Representative compounds of formula (I) include N-{ 3-[6-amino-4-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl]-4-fluorophenyl} -3,5-dichloropyridine-2-carboxamide, (R)-N-{ 3-[6-amino-4-cyclopropyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yI]-4-fluorophenyl} -5-chloro-3-fluoropyridine-2-carboxamide, (R)-4-(3’-methoxybiphenyl-3-yl)-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-6-amine, (R)-4-(3-(3-methoxy-pyridin-5-yl)-phenyl)-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-6-amine and (S)-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-4-fluorophenyl]-5-chloropyridine-2-carboxamide. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound as defined above and a pharmaceutically acceptable carrier for use in the treatment, prevention or prophylaxis of Alzheimer’s disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down’s syndrome, dementia associated with stroke, dementia associated with Parkinson’s disease or dementia associated with beta-amyloid.
Patent NZ-612097-A (NZ)
Title: Aerosol generating system with means for disabling consumable
Inventor: FLICK JEAN-MARC
IPC: A24F40/53
Filed: 2011-12-22
Abstract: An aerosol generating system with electrical disabling component is disclosed. The system comprises a storage portion (113) for storing an aerosol-forming substrate, an aerosol generating element for generating an aerosol from the aerosol-forming substrate, a control circuitry (109) in communication with the storage portion, and disabling means (201) within the storage portion (113) for rendering the storage portion (113) inoperable in the aerosol generating system in response to a disable signal from the control circuitry (109). A method in the system for controlling the aerosol generation is also disclosed. The method comprises sending a disable signal from the control circuitry (109) to the disabling means (201), when the amount of the aerosol-substrate in the storage portion (113) is below a threshold level or a determination of a malfunction in the system.
Patent NZ-616344-A (NZ)
Title: Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
Inventor: TOPORIK AMIR
IPC: C07K14/715
Filed: 2012-04-16
Abstract: Disclosed are isolated polypeptides of the sequences as defined in the specification; antibodies that bind them; and their use in treatment of cancer
Patent NZ-623628-A (NZ)
Title: Solid oral pharmaceutical formulations comprising amorphous (s)-methyl (1- ((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropy1-1h-pyrazo1-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (compound a)
Inventor: VERMA DAYA
IPC: A61K31/506
Filed: 2012-11-21
Abstract: Disclosed is solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases. A preferred embodiment is where the formulation includes an inner phase which is a solid dispersion comprising amorphous (S)-methyl(1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)pheny1)-1-isopropyl-1H-pyrazol-4-yepyrimidin-2-yeamino)propan-2-yl)carbamate (COMPOUND A); copovidone; and poloxamer 188 or sorbitol; and an external phase which comprises succinic acid, microcrystalline cellulose, crospovidone, colloidal silicon dioxide, and magnesium stearate.
Patent NZ-623812-A (NZ)
Title: Polypeptide constructs and uses thereof
Inventor: WILSON JR DAVID S
IPC: C07K19/00
Filed: 2012-10-29
Abstract: Disclosed is a polypeptide construct comprising a peptide or polypeptide signalling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen and wherein the peptide or polypeptide signalling ligand is selected from the group consisting of an IFN, IL-4 and IL-6.
Patent NZ-627800-A (NZ)
Title: Artificial fireplace
Inventor: FLYNN MUIRIS
IPC: F24C7/00
Filed: 2013-01-23
Abstract: Artificial fireplace for giving the impression of a burning fire. The fireplace comprises a box having an open or translucent port (3) providing a viewer with a line of sight into the box. The box has fuel bed elements provided in first and second portions, the first and second portions being substantially perpendicular to one another. An imaging means is also included (4) for displaying an image of flames. A dichroic mirror (6) merges at least one of a background image and the fuel bed elements with the image of the flames so as to provide a user with an impression of a burning fire.
Patent NZ-630851-A (NZ)
Title: Fusion polypeptides comprising mucin-domain polypeptide linkers
Inventor: ALVAREZ JUAN
IPC: A61K39/395
Filed: 2013-06-06
Abstract: Disclosed is a fusion protein having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker wherein the improved bioactivity of the fusion protein is increased half-life, wherein the first fusion partner is: sTNFR2, CTLA4, TACI, LFA, IL-1RI, IL-1RAcP, VEGF receptor, TPO receptor agonists, EPO receptor agonists, GLP-1, or exendin-4 and wherein the second polypeptide fusion partner comprises all or a portion of an immunoglobulin comprising an Fc region of IgG, IgA, IgE, IgM or IgD.
Patent NZ-700283-A (NZ)
Title: Substituted pyridopyrimidine compounds and their use as flt3 inhibitors
Inventor: KIM HONG WOO
IPC: C07D487/04
Filed: 2013-03-15
Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).
Patent NZ-701113-A (NZ)
Title: Soy protein products of improved water-binding capacity
Inventor: GREEN BRENT E
IPC: C07K1/14
Filed: 2011-12-16
Abstract: Disclosed is a method of producing a soy protein product having a soy protein content of at least 60 wt% (N x 6.25), dry weight basis, which comprises: (a) extracting a soy protein source with an aqueous calcium salt solution to cause solubilization of soy protein from the protein source and to form an aqueous soy protein solution, (b) separating the aqueous soy protein solution from residual soy protein source, (c) concentrating the aqueous soy protein solution while maintaining the ionic strength substantially constant by using a selective membrane technique, (d) optionally diafiltering the concentrated soy protein solution, (e) diluting the concentrated soy protein solution into water to cause the formation of a precipitate, (f) separating the precipitate from the diluting water, termed the supernatant, and (g) optionally drying the separated soy protein precipitate, wherein: (A) the separated soy protein precipitate from step (f) is dried and the dried protein is re-suspended in water, the resulting suspension is adjusted to a pH of 6 if necessary, the suspension is heat treated and either (i) the entire heated suspension is dried to provide the soy protein product or (ii) the insoluble protein is recovered from the heated suspension and the recovered insoluble protein is dried to provide the soy protein product, or (B) the separated soy protein precipitate from step (f) is re-suspended in water and the suspension is heat treated and either (i) the entire heat treated solution is dried to provide the soy protein product or (ii) the insoluble protein is recovered from the heat treated suspension and the recovered insoluble protein is dried to provide the soy protein product.
Patent NZ-703913-A (NZ)
Title: Systems and methods for inspecting and monitoring a pipeline
Inventor: FREESE ROBERT P
IPC: F17D5/02
Filed: 2013-09-09
Abstract: Disclosed are systems and methods for inspecting and monitoring an inner surface of a pipeline. One system includes a pig arranged within the pipeline and having first and second ends, one or more optical computing devices arranged on at least one of the first and second ends for monitoring a fluid within the pipeline. The optical computing devices including at least one integrated computational element configured to optically interact with the fluid and thereby generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the fluid. The system also includes a signal processor communicably coupled to the at least one detector of each optical computing device for receiving the output signal of each optical computing device and determining the characteristic of the fluid as detected by each optical computing device.
Patent NZ-706361-A (NZ)
Title: Nicotine composition
Inventor: HEARN ALEX
IPC: A24F47/00
Filed: 2013-08-23
Abstract: An inhalable composition comprising: nicotine or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric alcohol; and a glycol and/or glycol ether, characterised in that the ratio of monohydric alcohol : glycol or glycol ether by weight is from 6:1 to 1:1.
Patent NZ-711587-A (NZ)
Title: Substituted pyridine and pyrazine compounds as pde4 inhibitors
Inventor: VICKERS TROY
IPC: C07D403/06
Filed: 2014-03-06
Abstract: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non- human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.
Patent NZ-712105-A (NZ)
Title: Interrogatory cell-based assays and uses thereof
Inventor: NARAIN NIVEN RAJIN
IPC: G16B5/00
Filed: 2012-03-02
Abstract: A method for identifying a modulator of a biological system comprises (1) obtaining a first data set representing measured expression levels of a plurality of genes in cells associated with the biological system; (2) obtaining a first control data set representing measured expression levels of a plurality of genes in control cells; (3) obtaining a second data set from the cells associated with the biological system representing a measured functional activity or a measured cellular response of the cells associated with the biological system; (4) obtaining a second control data set representing a measured functional activity or a measured cellular response of the control cells; (5) generating a first causal relationship network model relating the expression levels of the plurality of genes and the functional activity or cellular response based solely on the first data set and the second data set using a programmed computing system, wherein the generation of the first causal relationship network model is not based on any known biological relationships other than the first data set and the second data set; (6) generating a second causal relationship network model relating the expression levels of the plurality of genes and the functional activity or cellular response of the control cells based solely on the first control data set and the second control data set; (7) generating a differential causal relationship network from the first causal relationship network model and the second causal relationship network model; and (8) identifying a causal relationship unique in the biological system from the generated differential causal relationship network, wherein a gene associated with the unique causal relationship is identified as a modulator of the biological system.
Patent NZ-716436-A (NZ)
Title: Improved ball game and apparatus
Inventor: LASZLO FRISTACZKI
IPC: F41J5/18
Filed: 2015-01-28
Abstract: For a ball game of the football type, a structured goal having a rigid, hemispherical surface bearing multiple colored zones for graded scoring purposes is provided, together with a layout for a playing field or pitch that limits player access near the goal by team, and a set of rules. The rigid goal lets the ball bounce back. For scoring purposes the zones may be equipped with individual zone impact-indicating means such as bells, electrical transducers, nearby cameras, or be supported on hinged mounts in order to show an impact by movement. The layout, the rules and the goal structure are intended to provide a faster game with higher score numbers.
Patent NZ-717495-A (NZ)
Title: Method and apparatus for treatment of respiratory disorders
Inventor: BATEMAN PETER EDWARD
IPC: A61M16/00
Filed: 2014-09-11
Abstract: An adaptive servo-ventilator that is configured to implement timed backup using a backup rate that is a function of the estimated spontaneous respiratory rate. An apparatus for generating a supply of air at positive pressure includes a processor and a memory storing program instructions configured to cause the processor to carry out a method comprising: controlling the therapy device to generate the supply of air at a positive treatment pressure that oscillates in synchrony with the patient’s spontaneous respiratory efforts; computing a typical recent ventilation of the patient; continuously computing a level of pressure support so as to bring a measure of ventilation towards a target ventilation that is dependent on the typical recent ventilation; estimating the spontaneous respiratory rate of the patient; and controlling the therapy device to deliver backup breaths in the absence of significant spontaneous respiratory efforts from the patient at a sustained timed backup rate that is a function of the estimated spontaneous respiratory rate.
Patent NZ-730123-A (NZ)
Title: Processes and intermediates in the preparation of c5ar antagonists
Inventor: FAN PINGCHEN
IPC: A61K31/445
Filed: 2015-09-28
Abstract: Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
Patent NZ-731859-A (NZ)
Title: Hinged greeting cards and gift card holders
Inventor: SEAN HIGGINS
IPC: B42D15/02
Filed: 2017-05-15
Abstract: A greeting card comprising 2 hinged sections, and a sleeve containing a gift card holder, where on opening the card the sleeve emerges from the card and the card holder from the sleeve
Patent NZ-754766-A (NZ)
Title: Dairy animal treatment apparatus, system and method
Inventor: GARY ARNOTT
IPC: A01K13/00
Filed: 2019-06-21
Abstract: A stepover dairy animal treatment apparatus and method of treating an animal is described. In art animal treatment devices, attempts have been made to automate treatment however, automated systems may be complex, expensive and unreliable in correct application of treatment agents. The apparatus described herein includes an enclosure configured to at least temporarily retain an animal in a stationary position; one or more sensors configured to detect the presence of an animal in the stationary position in the enclosure; at least one spray device located at the base of the enclosure, the spray device being arranged for an animal to step over it when moving into the stationary position. The spray device includes at least one spray outlet that is arranged to direct spray to the underside of an animal in the stationary position in the enclosure; and, during spraying, travels a path parallel to a longitudinal axis of the enclosure; and a controller configured to receive input from the one or more sensors and to actuate the spray device. The apparatus and method provide an alternate way to treat an animal in an automated manner.
Patent NZ-759863-A (NZ)
Title: Multi-arm structured illumination imaging
Inventor: HONG STANLEY
IPC: G02B21/06
Filed: 2019-01-14
Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system’s optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system’s optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.
Patent PT-106441-A (PT)
Title: Dispositivo de fixação para fixar um elemento tubular
Inventor: IRIARTE INIGO BERRIDI
IPC: F16L3/08
Filed: 2012-07-12
Abstract: DISPOSITIVO (1) DE FIXAÇÃO PARA FIXAR UM ELEMENTO TUBULAR A UM SUPORTE QUE COMPREENDE UMA ZONA (3) CENTRAL DE RETENÇÃO, SUBSTANCIALMENTE EM FORMA DE ARCO, APTA A SER APOIADA SOBRE O ELEMENTO TUBULAR. TAMBÉM COMPREENDE UM PRIMEIRO E UM SEGUNDO BRAÇO (5, 6) DE IMOBILIZAÇÃO DISPOSTOS DE MODO A FICAREM FACE A FACE ENTRE SI. OS BRAÇOS (5, 6) DE IMOBILIZAÇÃO PODEM ATRAVESSAR O SUPORTE E EXERCER PRESSÃO CONTRA A FACE OPOSTA DO SUPORTE, DE MODO A QUE O DISPOSITIVO (1) POSSA RETER O ELEMENTO TUBULAR ENTRE A ZONA (3) CENTRAL DE RETENÇÃO E A FACE DE APOIO DO SUPORTE. O DISPOSITIVO (1) DE FIXAÇÃO PODE SER UTILIZADO NUM RADIADOR QUE COMPREENDE, PELO MENOS, UMA RESISTÊNCIA, PELO MENOS, UM SUPORTE E UMA PLURALIDADE DE DISPOSITIVOS (1) DE FIXAÇÃO PARA FIXAR A RESISTÊNCIA AO SUPORTE.
Patent PT-117114-A (PT)
Title: Dispositivo de remoção de bainhas e método de remoção de bainhas
Inventor: KOHSUKE OKAZAKI
IPC: B26B27/00
Filed: 2021-03-15
Abstract: UM DISPOSITIVO DE REMOÇÃO DE BAINHAS COMPREENDE UM MEMBRO DE PREENSÃO DE FIOS ELÉTRICOS, UM PAR DE LÂMINAS EM FORMA DE V E UM MANDRIL DE DESCARNAGEM DE BAINHAS (61). O MEMBRO DE PREENSÃO DE FIOS ELÉTRICOS PRENDE UM FIO ELÉTRICO COMPREENDENDO UM FIO (101) E UMA BAINHA (102) COBRINDO O FIO (101). O PAR DE LÂMINAS (31) FORMA UM CORTE NA BAINHA (102) NUMA POSIÇÃO DE CORTE SITUADA MAIS PERTO DA PONTA DO QUE A POSIÇÃO ONDE O FIO ELÉTRICO ESTÁ PRESO PELO MEMBRO DE PREENSÃO DE FIOS ELÉTRICOS. O MANDRIL (61) PRENDE UMA PORÇÃO DE PONTA DE BAINHA QUE É UMA PORÇÃO DA PONTA DA BAINHA (102) ATÉ À POSIÇÃO DE CORTE. O MANDRIL (61) DESCARNA A PORÇÃO DE PONTA DE BAINHA DO FIO (101) REALIZANDO UMA ROTAÇÃO EM TORNO DE UMA DIREÇÃO DE EXTENSÃO DO FIO ELÉTRICO E UMA EXTRAÇÃO NA PORÇÃO DE PONTA DE BAINHA.
Patent RO-88924-A (RO)
Inventor: TERUO SAKAMOTO
IPC: A61K9/52
Filed: 1984-06-13
Abstract: Highly potent long-acting formulations of cefaclor for treating bacterial infections in humans or other animals comprise a rapid-release component and a slow-release component in a ratio of about 3:7 to about 5:5 by potency of cefaclor. Such formulations are convenient for administration or carrying about.
Patent RU-94003867-A (RU)
Inventor: BURAGA L P
IPC: A61K36/605
Filed: 1994-01-28
Abstract: FIELD: medicine and pharmacology, particularly, preparations for treatment of malignant tumors. SUBSTANCE: preparation contains the following ingredients, mas. %: ledum, 0.15-0.16; sweetflag, 0.16-0.15; burnet, 0.30-0.32; calendula, 0.60-0.62; horse sorrel, (root), 0.60-0.62; black currant (leaves), 0.92-0.94; immortelle, 0.60-0.62; dog rose (berries), 0.45-0.47; chicory (root), 0.60-0.62; plantain (grass), 0.60-0.62; black-berry mountain ash (berries), 0.30-0.32; bilberry leaves), 0.45-0.47; field horsetail, 0.45-0.47; black mulberry (berries), 0.60-0.62; thyme, 0.60-0.62; wormwood, 0.30-0.32; licorice (root), 0.30-0.32; John's-wort, 0,45-0.47; blackthorn (root), 0.14-0.16; glucose, 0.72-0.74; 40-% alcohol, the balance. EFFECT: additive has anticancerogenic activity and possesses ability to reduce growth and development and to increase disintegration of cellular tumors.
Patent RU-94003928-A (RU)
Inventor: SOKOLOV S I
IPC: B23D61/12
Filed: 1994-02-03
Abstract: FIELD: cutting members of sawing devices that may be used in different ranges of national economy for sawing, for example elastomers, cloth materials, hoses, rubber, polymers, foamed plastic and so on. SUBSTANCE: hacksaw includes working portion 1 that may be rectilinear, concave or convex one. Said portion has teeth, radially convex teeth, concave teeth, trapezoidal teeth, teeth with curvilinear groove, sine teeth. Teeth of working portion 1 have angle of tooth point β along its whole length or along whole length of teeth. At opposite side cutting teeth of said portion have roundings. Height H of segment of working portion 1 is selected according to relation given in description of the invention. EFFECT: enhanced efficiency and quality of sawing different non-metallic materials.
Patent RU-94014255-A (RU)
Inventor: JURGEN SHTOL TEFUS
IPC: C07D417/04
Filed: 1994-04-26
Abstract: FIELD: organic chemistry. SUBSTANCE: product: derivatives of 4-quinolyldihydropyridine of the general formulawhere: R,R,R- were given in the claim description, mixtures of their isomers or individual isomers and their salts that show valuable spectrum of pharmacological activity and effect, in part, on heart contraction and smooth muscle tone. EFFECT: improved method of synthesis, enhanced curative activity.