baber/WOPTO huggingface dataset:
Patent CA-2238430-A1 (CA)
Title: Pyrazole derivatives, method for preparing same, and pharmaceutical compositions containing said derivatives
Inventor: RINALDI MURIELLE
IPC: A61K31/4453
Filed: 1996-11-21
Abstract: Compounds of formula (I), wherein R1 is fluorine, hydroxy, (C1-5) alkoxy, (C1-5) alkylthio, hydroxy(C1-5)alkoxy, a -NR10R11 group, cyano, (C1-5) alkylsulphonyl or (C1-5) alkylsulphinyl; R2 and R3 are each (C1-4) alkyl or, taken together with the nitrogen atom to which they are attached, form a saturated or unsaturated 5- to 10-membered heterocyclic radical optionally substituted one or more times by (C1-3) alkyl or (C1-3) alkoxy; each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, halogen or trifluoromethyl, and when R1 is fluorine, R4, R5, R6, R7, and/or R9 may also be fluoromethyl; with the proviso that at least one of substituents R4 or R7 is other than hydrogen; each of R10 and R11 is independently hydrogen or (C1-5) alkyl, or R10 and R11, taken together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl optionally substituted by (C1-4) alkyl; a method for preparing same, and pharmaceutical compositions containing said compounds, are disclosed. Said compounds have very high affinity for central cannabinoid receptors.   (see formula I)
Patent CA-2238569-A1 (CA)
Title: The ob receptor and methods of diagnosing and treating weight
Inventor: TARTAGLIA LOUIS A
IPC: A61K38/00
Filed: 1996-11-27
Abstract: The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses <u>obR</u> nucleotides, host cell expression systems, ObR  proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an <u>obR</u> transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate <u>obR</u> gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
Patent CA-2238650-A1 (CA)
Inventor: LOHMANN DIETER
IPC: B29C39/42
Filed: 1996-12-06
Abstract: Procédé de formation d'une lentille ophtalmique adaptée à des durées d'utilisation prolongées sans provoquer de gonflement cliniquement significatif de la cornée et sans provoquer de gène à l'utilisateur. La lentille présente un équilibre de perméabilité à l'oxygène et de perméabilité ionique ou aqueuse, la perméabilité ionique ou aqueuse étant suffisante pour avoir de bonnes caractéristiques de mouvement sur l'oeil, de manière à obtenir un bon échange lacrimal entre la lentille et l'oeil. Le procédé de production nécessite une concentration d'oxygène de la matière polymérisable suffisamment basse pour produire une lentille présentant une haute perméabilité ionique. La concentration d'oxygène préférée dans la matière polymérisable est inférieure à 200 ppm.
Patent CA-2238994-A1 (CA)
Inventor: COHEN BERNARD
IPC: G05D7/06
Filed: 1996-12-04
Abstract: An ultrasonic apparatus and method for regulating the flow of a pressurized liquid through an orifice by applying ultrasonic energy to a portion of the pressurized liquid. The apparatus (100) includes a die housing (102) which defines a chamber (104) adapted to receive a pressurized liquid and a means for applying ultrasonic energy (116) to a portion of the pressurized liquid. The die housing (102) further includes an inlet (110) adapted to supply the chamber with the pressurized liquid, and an exit orifice (112) defined by the walls of a die tip (136). The exit orifice (112) is adapted to receive the pressurized liquid from the chamber (104) and pass the liquid out of the die housing (102). When the means for applying ultrasonic energy (116) is excited, it applies ultrasonic energy to the pressurized liquid without applying ultrasonic energy to the die tip (136) and modifies the flow rate of the pressurized liquid through the exit orifice (112). The method involves supplying a pressurized liquid to the foregoing apparatus (100), applying ultrasonic energy to the pressurized liquid but not the die tip (136) while the exit orifice (112) receives pressurized liquid from the chamber to modify the flow rate of the pressurized liquid through the exit orifice (112), and passing the pressurized liquid out of the exit orifice (112) in the die tip (136) at the modified flow rate.
Patent CA-2241993-A1 (CA)
Inventor: VAN DRAANEN NANINE AGNETA
IPC: A61P31/12
Filed: 1996-12-19
Abstract: L'invention concerne des dérivés benzimidazole et leur utilisation thérapeutique, en particulier pour la prévention ou le traitement d'infections virales telles que celles provoquées par des virus de l'herpès. L'invention concerne également la préparation de ces composés et des formulations pharmaceutiques les contenant.
Patent CA-2242380-A1 (CA)
Title: Method for producing cement
Inventor: SUTER WILLI
IPC: C04B7/42
Filed: 1996-11-15
Abstract: The invention relates to a method for producing cement, in which the starting materials of the cement are sintered in a furnace. Metal sols or metal compounds are sprayed in or injected preferentially in the last third of a kiln, so as to obtain, in this way, coloured cements, as well as to exclude undesirable oxidation steps of metals (particularly chromates).
Patent CA-2243924-A1 (CA)
Title: System for exhaust gas purification
Inventor: MIZUNO HIROSHIGE
IPC: B01D53/86
Filed: 1998-07-27
Abstract: A system for exhaust gas purification disposed in the exhaust pipe of an internal combustion engine, includes an adsorbent comprising a monolithic carrier and an adsorbent component having a hydrocarbon adsorptivity, loaded on the carrier, and a catalyst comprising a monolithic carrier and a catalyst component loaded on the carrier, having a purifiability for the harmful substances present in the exhaust gas emitted from the engine, the catalyst being provided downstream of the adsorbent in the flow direction of the exhaust gas. In the system, the adsorbent has a sectional shape satisfying the following relation: 1.2 ~ (major axis)/(minor axis) ~ 6.5 This system for exhaust gas purification enables the desorption of hydrocarbons from the adsorbent in a longer time and can remove the hydrocarbons generated during engine cold start, at a higher purification ratio.
Patent CA-2243946-A1 (CA)
Title: Reducing electrolyzed water and method for producing same
Inventor: HAN SHOUKA
IPC: C05G3/00
Filed: 1997-04-21
Abstract: Reducing electrolytic water which has a pH of 3 to 12, preferably 5 to 11, a redox potential of -200 mV or below, preferably -500 mV or below, and a common logarithm of the product of hydrogen ion concentration ¢H! and electron concentration ¢e! of -4.5 or above, preferably 0 or above, is useful as drinking water, agricultural fertilizer, injections including drips, dialysis solution, and face lotion, and exhibits excellent effects particularly in the medical field.
Patent CA-2244377-A1 (CA)
Inventor: STINGEL FREDERICK J JR
IPC: B65G1/08
Filed: 1997-01-21
Abstract: An improved reception system for the shelf assemblies of an article storage and dispensing system includes an article sensor, such as an electric eye, that is not dependent on weight, and a separate article arresting system and engages and smoothly decelerates an incoming article to rest, thereby reducing damage to fragile articles, such as glass containers.
Patent CA-2249803-A1 (CA)
Title: Trash rack with non-metallic reinforcing rod
Inventor: PASTORE JOSEPH
IPC: B07B1/46
Filed: 1998-10-06
Abstract: A trash rack for filtering large volumes of intake water generally of the type available to power-generating facilities. The trash rack includes reinforcing rods fabricated of non-metallic materials in a pultrusion fabrication process. The pultruded reinforcing rods are substantially lighter than prior steel reinforcing rods. The pultruded rods are flexible enough to give under impact and high-loading without fracture or permanent distortion, yet are strong enough to withstand the type of loading commonly experienced by such large-volume trash racks. <IMAGE>
Patent CA-2249827-A1 (CA)
Title: Magnetic component assembly
Inventor: MURTON ROBERT G
IPC: H02M3/28
Filed: 1998-10-08
Abstract: A magnetic component assembly includes a circuit board having at least one layer. A first winding is provided on at least one surface of a layer of the circuit board and a further winding is provided on the same or a different surface of the circuit board. A first magnetic core is associated with the first winding to define a first magnetic component and a further magnetic core is associated with the further winding to define a further magnetic component. There is thereby provided an assembly of two or more magnetic components integrated in a single circuit boardproviding an efficient space saving configuration. A particular application relates to the provision of integrated magnetic components for power supplies.
Patent CA-2249963-A1 (CA)
Inventor: GARRETT MICHAEL ERNEST
IPC: A41D31/00
Filed: 1998-10-14
Abstract: A material for a glove for handling cryogenic liquids which will not only be effective in preventing contact with cold metal but which will also avoid the risk of holdingcryogenic liquid in contact with the skin. If liquid splashes onto bare skin the flash gas released when the liquid approaches (to it) the extremely hot surface of the skin prevents physical contact of the droplet. Consequently liquid which splashes or even flows over our hand for a brief period will not cause injury. This bare skin can be maintained by using a glove manufactured out of a hollow mono-filament fibre such as terylene of about 1mm in diameter. The fibre can be knitted into a gloveshape to form a very open but fairly thick weave. The thickness of material means that cold pipes and fittings can be handled without coming into contact with the skin with the knitted hollow mono-filament acting as an effective thermal insulator whereas any liquid sprayed onto the gloved hand will not be trapped by the "cloth" but may be shaken free.
Patent CA-2250047-A1 (CA)
Title: Monoclonal antibodies binding human growth hormone (hgh)
Inventor: HANSSON YNGVE ELOF
IPC: C12P21/08
Filed: 1997-03-27
Abstract: The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
Patent CA-2252601-A1 (CA)
Inventor: GRAY MARTIN R
IPC: A61K31/00
Filed: 1997-05-19
Abstract: Process for the preparation of 2,2'-(1-methyl-1,2-ethanediylidine)bis[hydrazine carboximidamine] by a) removing impurities from aminoguanidine bicarbonate; b) reacting the aminoguanidine bicarbonate with methylglyoxal dimethylacetal in an aqueous isopropyl medium; and c) purifying the 2,2'-(1-methyl-1,2-ethanediylidene)bis[hydrazine carboximidamide] by crystallization from an acidic aqueous-isopropanol medium.
Patent CA-2257275-A1 (CA)
Title: New substituded 2,4-thiazolidinedione derivatives, processes for producing them and pharmaceutical compositions containing them
Inventor: DOARE LILIANE
IPC: C07D277/36
Filed: 1997-06-02
Abstract: The invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The invention more precisely features novel 5-phenoxyalkyl 2,4-thiazolidinediketones of general formula (I): in which A  represents one linear or branched alkylene group comprising 2 to 16 carbon atoms D represents one monocyclic, bycyclic or tricyclic, homocarbonaceous or heterocarbonaceous aromatic structure capable of enclosing one or several heteroatoms X represents the aromatic structure substituent and is as defined in claim 1 n is one integer ranging from 1 to 3 with the restriction that if A  represents one butyl radical, (a) does not represent the 4-chlorophenyl group.  The invention also disclosed tautomer, enantiomer, diastereoisomer and epimer forms of general formula (I) compounds, in free or salified form. The invention also discloses methods for obtaining general formula (I) compounds, their use as antidiabetic agents, and in the insulin resistance metabolic syndrome, as well as in the pharmaceutical compositions that contain general formula (I) compounds.
Patent CA-2258364-A1 (CA)
Title: Transient voltage surge suppressor having a switch with overtravel protection
Inventor: MURPHY PATRICK J
IPC: H01R13/66
Filed: 1999-01-11
Abstract: A transient voltage surge suppressor (TVSS) receptacle having front and rear matable casings including a plurality of through openings for receiving the blades of an electrical plug; an electrical circuit within the receptacle having at least one element adapted to clamp high transient voltages imposed thereon to a lower level; an alarm electrically connected to the at least one element for indicating the failure of the at least one element; and a switch connected to the alarm for disabling the alarm, is described. The switch includes a moveable on-off element and a generally U-shaped, metal switch blade having a first leg for contacting the moveable element; a second leg for contacting a contact of the alarm in response to travel of the first leg caused by the moveable element, the second leg; an integral U-shaped portion connecting the first and the second legs; and a non-linear intermediate portion in the second leg extending toward the first leg for absorbing over-travel of the switch blade.
Patent CA-2259407-A1 (CA)
Title: Drug delivery devices and process of manufacture
Inventor: FRAME RICHARD D
IPC: A61K9/70
Filed: 1997-07-03
Abstract: An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.
Patent CA-2259619-A1 (CA)
Title: Cytochrome p450 expression in enterobacteria
Inventor: WOLF CHARLES ROLAND
IPC: C12N15/09
Filed: 1997-07-17
Abstract: A bacterial cell containing a functional cytochrome P450 monooxygenase system, said cell comprising a genetic construct capable of expressing a cytochrome P450 and a genetic construct capable of expressing, separately from said cytochrome P450, a cytochrome P450 reductase wherein the N-terminus of the cytochrome P450 and the N-terminus of the cytochrome P450 reductase are each adapted to allow functional coupling of said cytochrome P450 and said cytochrome P450 reductase within said cell. A bacterial cell containing a cytochrome P450 comprising a genetic construct encoding, and capable of expressing, said cytochrome P450 wherein the cytochrome P450 comprises an N-terminal portion which directs the cytochrome P450 to a cellular compartment or membrane of the bacterial cell. The bacterial cells are useful as, for example, bioreactors, in drug testing and mutagenicity testing and as a source of cytochrome P450.
Patent CA-2261764-A1 (CA)
Title: Dietary supplements
Inventor: JACKSON SHERRY D
IPC: A23L33/15
Filed: 1997-07-08
Abstract: The present invention relates to dietary supplements for supplementing the dietary needs of women and preventing or reducing life stage associated health risks during each of their principal adult life stages (pre-perimenopause, perimenopause and menopause, or post-menopause). It also relates to a method of supplementing the dietary needs of women whereby an effective amount of a life stage appropriate dietary supplement is administered to a woman at each of her life stages throughout her life. The present also relates to dietary supplements for supplementing the specific phytochemical dietary needs of perimenopausal and menopausal women which contain low doses of phytoestrogens, and a method for such dietary supplementation.
Patent CA-2264432-A1 (CA)
Title: Apparatus and method for receiving position and control signals by a mobile machine
Inventor: GUDAT ADAM J
IPC: G01S5/00
Filed: 1999-03-03
Abstract: A base station receives GPS signals from GPS satellites and transmits a combined differential GPS (DGPS) signal and a command signal. At least one pseudolite receives the DGPS and command signals and combines the DGPS and command signals with a pseudo-GPS  signal. A GPS receiver on a mobile machine receives GPS signals from GPS satellites, and the combined signal from the pseudolite. The position signals are delivered to a machine position processor to generate a machine position signal. The command signals are delivered to a machine control processor to generate a machine control signal. The machine position signal and the machine control signal are delivered to a machine navigator to control the mobile machine.
Patent CA-2267571-A1 (CA)
Inventor: PINTSOV LEON A
IPC: G07B17/00
Filed: 1999-03-29
Abstract: A mail generation system and method includes means for processing data to generate mail piece information and first secure processing means for securely storing and encrypting mail piece information generated by the data processing means. Means are coupled to the data processing means for physically preparing mail pieces related to the generated mail piece information and for generating information related to the physical preparation of the mail. Second secure processing means securely store and encrypted information generated by the mail preparing means. Means sort the mail pieces and generate information related to the sorting and packaging of the mail pieces. Third secure processing means securely store and encrypt information generated by the mail sorting and packaging means. A part of the software program used to generate the mail piece information can be securely stored. Mail piece information to verify that the software program was employed to generate the mail piece information is encrypted.
Patent CA-2268452-A1 (CA)
Title: Ester-terminated polyamides of polymerized fatty acids useful in formulating transparent gels in low polarity liquids
Inventor: MACQUEEN RICHARD C
IPC: A61Q13/00
Filed: 1997-10-17
Abstract: A low molecular weight, ester-terminated polyamide may be blended with a liquid hydrocarbon to form a transparent composition having gel consistency. The ester-terminated polyamide is prepared by reacting "x" equivalent of dicarboxylic acid wherein at least 50 % of those equivalents are from polymerized fatty acid, "y" equivalents of diamine such as ethylene diamine, and "z" equivalents of monoalcohol having at least 4 carbon atoms. The stoichiometry of the reaction mixture is such that 0.9 < {x/(y+z)} < 1.1 and 0.1 < {(y+z)} < 0.7. The reactants are heated until they reach reaction equilibrium. The gel contains about 5-50 % ester-terminated polyamide, with the remainder preferably being pure hydrocarbon. The gels are useful in formulating personal care products and other articles wherein some degree of gel-like or self-supporting consistency is desired.
Patent CA-2269536-A1 (CA)
Title: Electrical machine with a single pole winding
Inventor: HILL WOLFGANG
IPC: H02K15/095
Filed: 1997-10-15
Abstract: Electrical machines with a radial air gap field, especially low-power EC dead-end feeders, having the advantage of individually wound poles.      The trapezoidal cross section of the slot and small slot openings in the direction of the air gap make it difficult to produce a compact winding.      According to the invention the body of the electric machine which forms the individual poles is made of soft magnetic segments. The segments are preferably made of axially stacked metal sheets having indentations on the edges forming the wall of the slot. This enables the conductor wire to be guided in a precise manner during the winding of individual poles.      At the air gap the pole shoes cover almost all of the perimeter and at the opposite end they form adjacent pole segments, preferably recesses in which retention pins, once mounted, are inserted axially and ensure radial fastening. In multiphase machines wound and unwound T-segments alternate it the direction of the width of the slot. X-segments have a pole surface which is fractionally increased according to the number of phases.  The invention enables highly efficient electric drive units to be produced at low cost.
Patent CA-2270495-A1 (CA)
Inventor: WHITSON ROBERT L
IPC: E04F11/116
Filed: 1999-04-30
Abstract: The present invention relates to a modular masonry step and deck assembly consisting of a plurality of like-shaped risers and a plurality of like-shaped treads that enable the assembly to have a variety of shapes, sizes and heights to provide a custom fit to a variety of buildings, mobile homes or trailers. The risers are dry stacked in a multi-tier, mufti-column, multi-row arrangement to form a base of the assembly. An inwardly expanding goove is formed in each corner of each riser. When aligned flush with adjacent risers and dry stacked one atop the other in a stacked bond arrangement, the groves form a continuous vertical channel. A semi-flexible locking key is formed inside the channel to secure the risers together, but accommodate movements caused by the freezing and thawing of the ground. Four differently shaped treads are used to form the walking surface of the step and deck assembly. Each tread shape is used to form a specific portion of the walking surface. A plurality of each like-shaped tread is used to form its specific portion of the walking surface to create a continuous lip around the perimeter of the steps and deck. Each of the four like-shaped treads has a specific design on its top surface to form an integral, continuous pattern on the steps and deck. The treads can be used to continue the design into a walkway.
Patent CA-2272183-A1 (CA)
Inventor: EIPEL HEINZ
IPC: C40B60/14
Filed: 1999-05-18
Abstract: The invention relates to an automatic pipetting apparatus, having a drive for moving a pipetting instrument from a source site to a target site, in which apparatus end stops (8-10, 14, 15), which can be finely adjusted automatically, for the movements of the pipetting instrument (1) generated by the drive are provided at the source site and/or the target site.
Patent CA-2273842-A1 (CA)
Title: A human 2-19 protein homologue, z219a
Inventor: CONKLIN DARRELL C
IPC: C12N15/12
Filed: 1998-10-06
Abstract: The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.