Patent SG-11201810358Y-A (SG)
Title: Compositions and methods for treating negative symptoms in non-schizophrenic patients
Inventor: LUTHRINGER REMY
IPC: A61P25/28
Filed: 2017-05-23
Abstract: Bautinismarcote7 P14cebo 511N•10132 mg ME4 4-101 6 4 mg 31.5 (4.7) 31.7 (4.2) 31.4 (4.3) 3 a ----------- .:;. ' - - - - - - - - - - - - — 4 --------------------- -Placebo - 32 mg --MIN-101 54 mg p-valor: 0.05; ** - 50.01 vows Omen 145087900 vl N 0 *It W O 20 17 / 205 393 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 November 2017 (30.11.2017) WIPO I PCT oimiolollm inn Him!! oniniou oimIE (10) International Publication Number WO 2017/205393 Al (51) International Patent Classification: A61K 31/454 (2006.01) A61P 25/16 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: PCT/US2017/034030 (22) International Filing Date: 23 May 2017 (23.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/341,590 25 May 2016 (25.05.2016) US (71) Applicant: MINERVA NEUROSCIENCES, INC. [US/US]; 1601 Trapelo Road, Suite 284, Waltham, Massa- chusetts 02451 (US). (72) Inventors: LUTHRINGER, Remy; 2 me de Jargonnant, 1207 Geneva (CH). DAVIDSON, Michael; 11 B Nitzana Street, Apt. 10, 6811713 Tel Aviv (IL). (74) Agent: ERLACHER, Heidi A. et al.; Cooley LLP, 1299 Pennsylvania Avenue, NW, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: COMPOSITIONS AND METHODS FOR TREATING NEGATIVE SYMPTOMS IN NON-SCHIZOPHRENIC PATIEN- TS FIGURE 1 PANSS Negative Symptoms Score (Pentagonal Structure) Change horn Baseline (WARM) (ITT Population) WEEK (57) : The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis of schizophrenia. The compositions and methods employ a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, solvate or polymorph thereof [Continued on next page] WO 2017/205393 Al MIDEDIMOMOIDEIROIDEM00101011101100111100MEMOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3))