Patent SG-11201900446Q-A (SG)
Title: Crebbp related cancer therapy
Inventor: GRASSIAN ALEXANDRA
IPC: C12N9/10
Filed: 2017-07-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11011110111010101111101 110 1 010110101110111101110011111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\" WO 2018/022637 Al 01 February 2018 (01.02.2018) W I P0 I P C T (51) International Patent Classification: (74) Agent: VETTER, Michael L. et al.; Choate, Hall & Ste- C12N 9/10 (2006.01) wart LLP, Two International Place, Boston, Massachusetts (21) International Application Number: 02110 (US). PCT/US2017/043757 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 25 July 2017 (25.07.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (25) Filing Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (26) Publication Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/366,249 25 July 2016 (25.07.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: EPIZYME, INC. [US/US]; 400 Technology TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Square, Cambridge, Massachusetts 02139 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: GRASSIAN, Alexandra; c/o Epizyme, Inc., kind of regional protection available): ARIPO (BW, GH, 400 Technology Square, 4th Floor, Cambridge, Massachu- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, setts 02139 (US). RIBICH, Scott; c/o Epizyme, Inc., 400 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Technology Square, 4th Floor, Cambridge, Massachusetts TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — 02139 (US). SMITH, Jesse; c/o Epizyme, Inc., 400 Tech-EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, nology Square, 4th Floor, Cambridge, Massachusetts 02139 — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (US). HARVEY, Darren; c/o Epizyme, Inc., 400 Technol- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ogy Square, 4th Floor, Cambridge, Massachusetts 02139 KM, ML, MR, NE, SN, TD, TG). (US). = = (54) Title: CREBBP RELATED CANCER THERAPY = — = = -0.5- = = — = — — — _ -1.5- = = = _= — 0 = ''' — 1-1 IN -3 . 5 ' M N to t f 1 0 AUTONOMIC_GANGLIA ()BREAST 0 ENDOMETRIUM O KIDNEY fa LARGE INTESTINE 0 L VER - 0 ONG 0 OESOPHAGUS 9 OVARY 0 PANCREAS 0 SKI 0 SOFT TISSUE lb STOMACH • oper ..aradigeslive_tract . t• • URINARY_TRACT 1 1 0 CENTRALNERVOUS_SYSTEM is 1 '::EE= . , 1 81 1 1 4 4''''t 1 8 1 It II It 11 n H 18 18 11 I8 11 H 11 1E 18 11 1 II iv iii Ei -,, I 1 1 1 1 11 1 1 l i ! f\"1 0 Figure 2A ,—, C::::) (57) : The present disclosure provides novel cancer therapies. The treatment of cancers harboring EP300 mutations with N CREBBP inhibition therapy is described. [Continued on next page] WO 2018/022637 Al MIDEDIMOMMIDIREEMOTHOHEIIINHINVOIS Published: — with international search report (Art. 21(3))