Patent SG-11201903487S-A (SG)
Title: PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
Inventor: ZHAO QIAN
IPC: A61P35/00
Filed: 2017-10-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 Ill 11111 Organization 0 11101 010 11111 01 110 1 0 011111111111 010 11111 010 1111 MI MI OM International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2018/081417 A3 03 May 2018 (03.05.2018) WIP0 I PCT (51) International Patent Classification: Boulder, Colorado 80301 (US). EARY, Charles Todd C07D 471/22 (2006.01) A61P 35/00 (2006.01) [US/US]; 281 Tresser Blvd., Stamford, Connecticut 06901 A61K 31/519 (2006.01) (US). (21) International Application Number: (74) Agent: DORIGO, Andrea et al.; Fish & Richardson P.C., PCT/US2017/058518 P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 26 October 2017 (26.10.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, PCT/US2016/058951 KR, MG, 26 October 2016 (26.10.2016) US OM, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/524,801 26 June 2017 (26.06.2017) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (72) Inventors; and TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicants: ZHAO, Qian [US/US]; c/o Array BioPhar- (84) Designated States (unless otherwise indicated, for every ma Inc., 3200 Walnut Street, Boulder, Colorado 50301 kind of regional protection available): ARIPO (BW, GH, (US). SPENCER, Stacey [US/US]; c/o Array BioPharma GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = = JIANG, Yutong [US/US]; c/o Array BioPharma Inc., 3200 TM), Walnut Street, Boulder, Colorado 80301 (US). HAAS, Ju- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, lia [US/US]; c/o Array BioPharma Inc., 3200 Walnut Street, European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — Title: PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF (54) = N --N1 \ --- N O 0 R 2 a R 2 N— R 4 = _ = IIIm R3a R3 Formula C, = — = = = = - ----% - ' — = \ N ---, . .. `- .--' M F N IN Formula I 1-1 71' 1-1 GO 0 .-- (57) : In some embodiments, provided herein are processes for preparing a compound of Formula C or a salt thereof, as - GC 1 -1 disclosed herein. In some embodiments, provided herein is a compound of Formula I or a pharmaceutically acceptable salt, solvate or 0 hydrate thereof. In some embodiments, provided herein is a solid form of the compound, such as a crystalline form of the compound ei crystalline Form I. [Continued on next page] WO 2018/081417 A3 MIDEDIMOMOIDIONDEIDIONIMHOIDIVOIDEMOMI00# MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 07 June 2018 (07.06.2018)