Patent SG-11201900361R-A (SG)
Title: Methods of treating prostate cancer
Inventor: Hawkins Rebecca
IPC: A61P35/00
Filed: 2017-07-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 Ill IOU 0 11101 010 11111 01 110 1 0 011101 0111 001 11111 010 1111 MEV OEM Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/023017 Al 01 February 2018 (01.02.2018) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) (71) — (72) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 31/454 (2006.01) A61P 35/00 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2017/044413 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 28 July 2017 (28.07.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (84) Designated States (unless otherwise indicated, for every Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/368,466 29 July 2016 (29.07.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/369,239 01 August 2016 (01.08.2016) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Applicant: JANSSEN PHARMACEUTICA NV TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE). KM, ML, MR, NE, SN, TD, TG). Inventor; and Applicant: GOTTARDIS, Marco [US/US]; 9 Harris Declarations under Rule 4.17: Road, Princeton, New Jersey 08540 (US). — as to applicant's entitlement to apply for and be granted a patent (Rule 4. 17(ii)) Inventors: HAWKINS, Rebecca; 1400 McKean Road, — as to the applicant's entitlement to claim the priority of the Spring House, 19477 (PA). SNYDER, Linda; 1400 McK- earlier application (Rule 4 . 17 (iii)) can Road, Spring House, Pennsylvania 19477 (US). YA- MADA, Douglas H.; 1400 McKean Road, Spring House, Published: Pennsylvania 19477 (US). — with international search report (Art. 21(3)) Agent: SHIRTZ, Joseph F. et al.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, New Jer- sey 08933 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — = (74) = (81) = = = Title: METHODS OF TREATING 100- 80- o c 60- ..m Tb 40- • - = c ._ 'e,.. ' 20 - 0 - 20 . 4 PROSTATE CANCER = (54) = = = = - • -A- C4-2B -A- LnCaP • = = • • • ...vir ...•- -yr- LnCaP AR.TB -e- VCaP -N- 22Rv 1 — = 1-1 IN 1-1 O M N 0 --.... 00 1-1 0 N (57) 0 Figure 1. : Disclosed are methods -2 . . . . . -1 0 1 2 3 log [niraparib], All Niraparib inhibits the growth of human prostate tumor cell lines in vitro. of treating prostate cancer by administering niraparib to a subject in need thereof.