baber/WOPTO huggingface dataset:
Patent EA-202091596-A1 (EA)
Title: Антитела к pd-1 и способы лечения
IPC: A61K47/60
Filed: 2019-01-11
Abstract: В данном документе представлены антигенсвязывающие белки для PD-1 и соответствующие нуклеиновые кислоты, векторы, клетки-хозяева, наборы и фармацевтические композиции. Дополнительно представлены способы получения антигенсвязывающих белков для PD-1 и способы лечения субъекта.
Patent EA-202091707-A1 (EA)
Title: Хиноксалиноновые соединения, композиции, способы и наборы для повышения эффективности редактирования генома
IPC: C07D241/44
Filed: 2019-01-16
Abstract: Предложены соединения, способы редактирования целевой геномной области(ей), способы репарации разрыва ДНК через путь HDR, способы ингибирования или подавления репарации разрыва ДНК, проходящей через путь NHEJ, и способы модификации экспрессии гена(ов) или белка(ов), которые включают введение в одну или несколько клеток, которые содержат одну или несколько целевых геномных областей, системы редактирования генома и ингибитора ДНК-протеинкиназы (ДНК-РК), которые описаны в настоящей заявке. Предложены также наборы и композиции для редактирования гена-мишени, которые содержат систему редактирования генома и ингибитор ДНК-РК, которые описаны в настоящей заявке.
Patent EA-202092807-A1 (EA)
Title: Конструирование в-лимфоцитов путем использования эндогенной индуцируемой активацией цитидиндезаминазы
IPC: C12N15/90
Filed: 2019-05-29
Abstract: В заявке описывают способ конструирования В-лимфоцитов с использованием цитидиндезаминазы В-лимфоцитов, индуцированной активацией. Таким образом, можно избежать использования сконструированных нуклеаз, таких как нуклеаза Cas. Сконструированные В-клетки полезны для получения индивидуальных антител и для терапии В-клетками. Соответственно, настоящее изобретение также предусматривает конструированные В-клетки и индивидуальные антитела, вырабатываемые сконструированными В-клетками.
Patent ES-2223198-A1 (ES)
Title: Hydromechanical drive of a cross-shearing station
Inventor: KNODLER RICHARD
IPC: B30B15/28
Filed: 2000-10-04
Abstract: A press has a tool which comprises an upper tool part and a lower tool part. The upper tool part is held on the press slide, while the lower tool part is stationarily mounted in the press frame. A movable forming element, such as a shearing blade, is provided in the lower tool part. The press drive is used for driving the shearing blade. For this purpose, a hydraulic force transmitting device is provided in the lower tool part and is actuated by way of a pressure pin. For the actuation, the slide or an element fixedly connected with the slide is used, the slide, in turn, being driven by the press drive. A hydraulic force transmitting device in the lower tool part permits a liberal tool construction and an arrangement of corresponding force transmitting devices for the at least temporary coupling between the slide and the hydraulic force transmitting device at points which hinder neither the access to the tool nor the workpiece transfer.
Patent ES-2189637-A1 (ES)
Title: Stretching device for garments.
Inventor: PRAT GONZALEZ PEDRO
IPC: G01L5/00
Filed: 2001-04-03
Abstract: Consists of a stretching device for garments, such as lingerie or a bathrobe (1) which has means for attaching it to the garment, at least one part of the body, and is characterised in including one or more sensors (5) of the amount of force to which it is subjected, or the stretching device has been subjected, of which there is at least one, and which incorporates electromechanical means for stretching and releasing (3) the garment, a device to store a particular cut (9) and means (7) for supplying power to the said sensors (5) and stretcher (3).
Patent ES-2206041-A1 (ES)
Title: Watchtower for beach monitoring has kiosk provided at bottom of upright structure, and stair provided from interior of kiosk to access platform to enable access to monitoring platform
Inventor: EGIDO SERRANO CESAR
IPC: E04H1/12
Filed: 2002-10-11
Abstract: The watchtower has a monitoring platform (7) supported by an upright structure (1), and a kiosk (4) provided at the bottom of upright structure. A stair (8) is provided from the interior of kiosk to an access platform (9) to enable access to the monitoring platform. A cover (5) protects the perimeter of kiosk and is secured by lateral braces (6).
Patent ES-2234388-A1 (ES)
Title: Device for suspending tables in vertical and horizontal direction, has profile whose cross-sectional section is provided with rectangular general structure, where profile is equipped with main side of device
Inventor: MARTINEZ PEREZ HITA SALVADOR
IPC: A47G1/16
Filed: 2003-03-06
Abstract: The device has a profile whose cross-sectional section is provided with a rectangular general structure. The profile is equipped with a main side of the device. An intermediate cavity opens toward an outer side of the device. The intermediate cavity is located to opposite to a main partition of the profile. Detachable covers are connected to ends of the profile that is equipped in top part of sliding elements.
Patent ES-2275364-A1 (ES)
Title: Construction system for e.g. walls, borders, has each closure panel, made of high density core covered by e.g. steel, aluminum, or PVC plates, formed with dovetail joints for connection with similar joints of other panels
Inventor: GALLEGO LEON JOSE JUAN
IPC: E04G9/10
Filed: 2003-03-25
Abstract: The system has closure panels, each made of high density core covered by sufficiently rigid plates of e.g. steel, aluminum, polyvinyl chloride (PVC). Dovetail joints are formed on each closure panel for connection with similar joints of other panels. When used in building borders, the panels may be incorporated with an intermediate insulation layer as well as corner elements for keeping the set of panels in place. The panels may be laid horizontally within a perimetral enclosure when used in building roofs.
Patent ES-2265705-A1 (ES)
Title: Ventilated facade system for use in e.g. buildings, has inner metal insulator incorporated between prefabricated panels which are fixed together by anchors having end connections conforming profiles of visible outer plates
Inventor: VIVO PASCUAL ENRIQUE
IPC: E04B2/96
Filed: 2003-07-29
Abstract: The system incorporates an inner metal insulator between the prefabricated panels which are fixed together using metallic anchors and which are used to form a building structure. The anchors are formed with long shape crossing the prefabricated panels, and formed with end connections that conform to the vertical and horizontal profiles of the outer plates visible at the facade of the building. Closing plates are defined between the prefabricated panels of the facade. Coating plates are provided to cover the ventilated prefabricated panels.
Patent ES-2241458-A1 (ES)
Title: Perfected blind, has drag elements fixed inside guides, where elements define chain and incorporate lateral axis, automatic tilting device fixed with independent tilted element of guides, and groove formed by sliding projection in chain
Inventor: PALLARES RIUS JOAQUIN
IPC: E06B9/34
Filed: 2003-10-03
Abstract: The blind has parallel bars, guides of a side slip, and drag elements fixed inside the guides. The elements define a chain and incorporate a lateral axis. An automatic tilting device is fixed with an independent tilted element of the guides. A groove is formed by sliding a projection in the chain.
Patent ES-2262391-A1 (ES)
Title: Air conditioning system has heat accumulator, provided inside enclosure, which stores phase transition medium having phase change temperature lower and higher than maximum and minimum outside temperatures
Inventor: CULUBRET VIVES JOAQUIN
IPC: F28D20/02
Filed: 2004-05-06
Abstract: A heat accumulator, equipped inside an enclosure, stores a solid-liquid phase transition medium. The phase change temperature of the medium is lower and higher than the maximum and minimum outside temperatures. The accumulator takes in or expels out outside air via control device and air entry and exit, when the phase change temperature is lower or higher than the outside temperature.
Patent ES-2258911-A1 (ES)
Title: Gas cooking plate
Inventor: HERRERA ESTRADA PEDRO
IPC: F23N5/10
Filed: 2004-11-10
Abstract: The gas cooking hob has at least one gas tap (7) for a gas burner (1) and a control unit (35) with an electric switch (23,59) which with a pressed or rotated operation of the gas tap generates a control signal in the control unit. The switch is electrically connected to the control unit via at least one earthing connection (41,43). The control unit and the electric switch are connected in series in a signal circuit (5). The electric switch is connected via a signal line (33) to a first electrical connection (71) of the control unit.
Patent ES-2270743-A1 (ES)
Title: Straightening and stretching instrument for use in spine, has rectangular body formed with symmetrical grooves on lateral sides, in which braces pass through symmetrical grooves for conforming body contour of user
Inventor: BERBIS GONZALEZ MERCEDES
IPC: A61F5/02
Filed: 2006-12-12
Abstract: The instrument has a rectangular body which has a U-shaped section, and which is formed with a hollow channel on its outer surface. Symmetrical grooves are formed on the lateral sides of the rectangular body. Braces pass through the symmetrical grooves for conforming the body contour of the user.
Patent ES-2324272-A1 (ES)
Title: Device for rescuing people from a small enclosed space via manholes and method for using and uses of same
Inventor: MERINO RODRIGUEZ ALBERTO
IPC: A61G1/00
Filed: 2008-01-31
Abstract: A device for rescue from the interior of a confined space via a manhole which includes at least a tray, a prying structure and two elements for tightening of a person to the tray and the prying structure respectively. The tray is elongated and includes on one of its sides at least two means of coupling where the prying structure is inserted the other side being smooth. Also defined is a method of utilisation of said device.
Patent ES-2453202-A1 (ES)
Title: Operating conditioning and instrumental learning box for rabbits
Inventor: LEAL CAMPANARIO ROCIO
IPC: A01K15/00
Filed: 2012-09-04
Abstract: The invention relates to an operating conditioning and instrumental learning box for rabbits. It enables the simultaneous recording of the brain activity and study of the behaviour and learning of the rabbit. At least one of the walls of the box (1) is transparent in order to allow the observation of the animal and the box contains a lever (2) on one of the walls and a feeding tub (4) on the opposite wall, said feeding tub being connected to a food dispenser (3) arranged outside the box (1). It can also comprise a lamp (9) for emitting a light signal, and a loudspeaker (10) for emitting a sound signal.
Patent ES-2531737-A1 (ES)
Title: Method and system for evaluating the structural integrity of lattice or reticulated towers
Inventor: PEREZ MARTINEZ MARCO ANTONIO
IPC: G01M5/00
Filed: 2013-09-18
Abstract: Non-destructive self-diagnostic method and system for evaluating the structural integrity of lattice and reticulated towers, with which an automatic evaluation is carried out which enables possible states of degradation of the tower to be identified, as well as abnormal working conditions which induce states of structural overload. The method developed consists of identifying structural damage or anomalies based on alterations in the combined static and dynamic response of the structure, quantifiable by means of a series of criteria and methods of correlation [1-5]. The system is constituted by a monitoring system (103) formed by a dynamic module (104)(107) for determining the dynamic response, a static module (109) for estimating the local solicitation planes and/or the tilted trihedrals, a central module (208) which acts as an acquisition, storage and remote sending system of data to another post-processing (209) and control module and expert structural self-diagnostic system.
Patent ES-2723373-A1 (ES)
Title: Air conditioner
Inventor: KATO TOMOHIRO
IPC: F24F11/48
Filed: 2018-04-11
Abstract: This air conditioner is provided with: a heat exchanger (indoor heat exchanger (15)); a fan cleaning part (24) that cleans a blower fan (indoor fan (16)); and a control unit (30) that causes the fan cleaning part to selectively come into contact with both the heat exchanger and the blower fan. The control unit causes the heat exchanger to generate dew condensation water in a refrigeration cycle, before the fan cleaning part comes into contact with the heat exchanger or while the fan cleaning part is in contact with the heat exchanger.
Patent JO-P20190239-A1 (JO)
Title: Vmat2 inhibitor compounds and compositions thereof
Inventor: BRANUM SHAWN
Filed: 2017-06-16
Abstract: Provided is a compound selected from compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof: (I) wherein R1, R2, R3 and R4 are as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, neurological and psychiatric diseases and disorders. Also disclosed are compositions containing such compounds in combination with a pharmaceutically acceptable carrier, as well as methods relating to their use in subjects in need thereof.
Patent JO-P20210289-A1 (JO)
Title: Mcl-1 inhibitor antibody-drug conjugates and methods of use
Inventor: OLIVIER GENESTE
Filed: 2020-05-19
Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
Patent RS-20140002-A1 (RS)
Title: Application of methenamine hydro sulphocyanate for the production of drugs for infections caused by bacteria with the new delhi metallo-beta-lactamase (ndm-1) gene
IPC: A61K31/095
Filed: 2013-12-30
Abstract: Invention herewith described refers to the application of methenamine hydro sulphocyanate for the production of drugs for infections caused by bacteria with the New Delhi metallo-beta-lactamase (ndm-1) gene. The therapeutic effect is achieved thanks to the circumstances that methenamine hydro sulphocyanate applied as a drug starts "the immunity thunderstorm" – the state of the immunity system which is characterized by an increased intensity of cellular as well as humoral components of the immune response. In such a state, the bacteria with NDM-1 gene partially damaged by synergic action of formaldehyde as the degradation product of methenamine and sulphocyanate ion, become recognizable for the immune system and are more intensively exposed to the specific defense mechanisms, which lead to the desired therapeutic effect.
Patent RS-20181034-A1 (RS)
Title: Device for continuous dosing of essential oils and perfumes
Inventor: GUTOVIĆ ZORAN
IPC: A45F5/02
Filed: 2018-08-31
Abstract: <p>Device for continuous dosing of essential oils and parfumes comprises a reservoir (1) or a tube (1a) capable of receiving volatile substances such as essential oils and perfumes, closed with a plug (3) through which a wick (2) or a capillary tube (2a) passes. Device has at an upper opening a temporary cap (7) or permanent cap (9) for stoping or regulating evaporation. The reservoir (1) or the tube (1a) is protected with annular cylinder (5) or semi-annular cylinder (5a). The reservoir (1) or the tube (1a) can be placed in a capsule (5c) which in this solution also serves to attach a buckle (4) or a magnet (12) to the reservoir (1) or tube (1a).</p>
Patent RS-20200033-A1 (RS)
Title: Acaricidal and insecticidal mixture of paraffin oil and glycerol
Inventor: PAVLIĆEVIĆ ALEKSANDAR
IPC: A01P7/04
Filed: 2020-01-13
Abstract: The invention relates to the optimization and rationalization of the formulation and application of paraffin oil in the control of red chicken mite Dermanyssus gallinae and other species of harmful insects and mites, with glycerol and emulsifier.
Patent SG-126702-A1 (SG)
Title: Napkin package
Inventor: KASHIWAGI MASAHIRO
IPC: A61F13/00
Filed: 2002-07-04
Abstract: A napkin package is difficult to form permanent folding, twisting or corrugation in a leakage preventing wall as folded and wrapped by a packaging sheet, to ensure raising of the leakage preventing wall from a surface of a sanitary napkin after opening the package for achieving satisfactory side leakage preventing effect. A sanitary napkin has longitudinally extending leakage preventing walls on both sides of a liquid absorbing portion. A reinforcement sheet is provided on a surface side of a folded sanitary napkin with covering a portion of the folding line, the reinforcement sheet is bent at a position corresponding to the folding line without forming crease, and portions of the leakage preventing walls located corresponding to the portion across which the folding line extends, are urged onto an outer surface of the bent portion of the reinforcement sheet by the elastic tension force.
Patent SG-125185-A1 (SG)
Title: Package
Inventor: TORU ICHIKAWA
Filed: 2006-01-27
Abstract: A package has a package body formed by mating film materials and sealing peripheral edge portions of the mated film materials so as to form a content accommodation compartment inside the sealed peripheral edge portions, said sealed peripheral edge portions being subjected to an easily peel-off treatment so that the sealed peripheral edge portions are separated and peeled off from each other when the package is opened. A seal opening starting portion is formed outside of one of the sealed peripheral edge portions so that the film materials are separated from each other at the seal opening starting portion, and at least one projection is provided on at least one of inner and outer side surfaces of the film materials forming the seal opening starting portion.
Patent TR-201722772-A1 (TR)
Title: Hemositometre tabanlı otomatikleştirilmiş hücre sayım sistemi.
Inventor: GÖKHAN ŞENGÜL
IPC: G01N33/48
Filed: 2017-12-29
Abstract: Buluş, hemositometre tabanlı mikroskobik görüntüler üzerinde görüntü işleme ve makine öğrenimi ile otomatik hücre sayım, canlılık ve morfoloji analizi yapılmasını sağlayan hücre sayım sistemi ile ilgilidir. Buluş özellikle, sayım yapılacak alan belirlenmesini sağlayan, görüntü işleme tekniklerinin uygulandığı, hücrelerin canlılık ve morfolojik analizleri de makine öğrenme tabanlı olarak yapılmasını sağlayan hücre sayım sistemi ile ilgilidir.
Patent TR-202006913-A1 (TR)
Title: 2 Serbestlik dereceli protez bilek yapılanması.
Inventor: RAMAZAN ÜNAL
IPC: A61F2/50
Filed: 2020-05-04
Abstract: Mevcut buluş, kol ile bir el mekanizması arasındaki bağlantıyı sağlayan; el mekanizmasının yerleştirileceği en az bir bağlantı yuvası (11.1), protez bilek biriminin (1) dönme hareketini sağlayan en az bir bağlantı parçası (12.1) içeren bilek tabanı birimi (10), bir mafsal yuvası (20.1) ve bir mafsal gövdesi (20.2) içeren bir mafsal (20), mafsal gövdesinin (20.2) yerleştirildiği bir kilitleme mekanizması ağzı (30.1) içeren ve protez bilek biriminin (1) sabit veya hareketli olmak üzere iki pozisyonda çalışmasını sağlayan kilitleme mekanizması (30), mafsal (20) ve kilitleme mekanizmasının (30) içerisine yerleştirildiği ve mafsal (20), kilitleme mekanizmasının (30) hareketlerini sınırlandıran bir kol bağlantı birimi (40) ve protez bilek biriminin (1) eklem katılığını sağlayan en az bir tendon (50) içeren bir protez bilek birimidir (1).
Patent AR-024788-A1 (AR)
Title: Metodo de transformacion y plantas transgenicas producidas con el mismo.
Filed: 2000-07-18
Abstract: Métodos para producir, con una frecuencia alta, plantas transgénicas que contiene pocas, si alguna, secuencias de vector, poseen patrones de integracionsimples, contienen pocas copias del transgen en cada locus, expresan el transgen en todas las etapas de desarrollo y no exhiben silenciamiento de transgenes.El método comprende introducir casetes de expresion de transgenes mínimos, que están substancialmente o totalmente desprovistos de secuencias de vector,mediante transferencia directa de ADN,preferentemente mediante bombardeo de partículas o microproyectiles. Esta invencion también se relaciona con célulasvegetales transformadas, las plantas transgénicas regeneradas a partir de las mismas y subpartes de dichas plantas transgénicas producidas con los métodos deesta invencion. También incluye toda la progenie y la progenie subsiguiente (es decir, todas las generaciones subsiguientes) derivada de los transformantesprimarios por autocruzamiento o cruzamiento.
Patent AR-026300-A1 (AR)
Title: Nuevos compuestos para el tratamiento de las complicaciones vasculares relacionadas con la diabetes y con el envejecimiento, el proceso para su preparaciony los usos terapeuticos.
IPC: A61K31/444
Filed: 2000-10-30
Abstract: Describe compuestos nuevos de la serie piridinio utiles para el tratamietno de las complicaciones vasculares por diabetes y relacionadas con elenvejecimiento, incluyento a las enfermedades del rion en nervios, aterosclerosis, retinopatías, trastornos dermatologicos y decoloracion de los dientes, laruptura el AGE pre formado, de la formula general 1, o sus sales faramcéuticamente aceptables, donde R1 es -R4-R5 o -N(R7)N(R7)R9; R4 se selecciona del grupoformado por -N(R7)R6O-, -N(R7)R6N(R7)-, OR6O , y -OR6N(R7)-, donde R6 es alquilo; R5 se selecciona del grupo formado por alquilo, arilo incluyendo heteroarilo,-COR7, SO2 R7; -C(S)NHR7, -C(NH)MHR7, -COR10, -C(O)NHR7 y -N(R7)N=CR7R10 donde R7 se selecciona del grupo formado por H, alquilo y arilo incluyendo heteroarilosi R7 fuera diferente para R1 y R3 en el mismo compuesto; R2 se selecciona del grupo formado por H, alquilo ya rilo incluyendo heteroarilo si R7 fueradiferente para R1 y R3 en el mismo compuesto; R2 se selecciona del grupo form ado por F, CL, Br, I, OR7, NO2, alquilo,a rilo incluyendo heteroarilo, formilo,acilo, C(O)NR7R10, C(I)OR7, NR7R10, N=C(R7)(R10), SR7, SO2NH2, SO2 alquilo y SO2 arilo, y m es 0, 1 o 2; R3 se selecciona del grupo formado por R7, OR7, N(R7)(R10), N=C(R7 )(R10), N(R7)N(R7)(R10), N(R7) N=C(R7)(R10) y CH(R7)C(O)R8 donde R8 se selecciona del grupo formado por R7, OR7 y NR7R10; R9 se selecciona delgrupo formado por hidrogeno, alquilo,a rilo incluyendo heteroarilo, C(O)R10, -SO2R10, -C(S)NHR10, -C(NH)NH(R 10) y -C(O)NHR10, R10 se selecciona del grupoformado por H, alquilo o arilo incluyendo heteroarilo y en cada caso, es opcionalmente diferente del sustituyente R10, si R10 fuera diferente de R1 y R3 en elmismo compuesto; X se selecciona del grupo for mado por un ion de haluro, acetato, perclorato, sulfonato, oxalato, citrato, tosilato, amleato, mesilato,carbonato, sulfito, hidrogeno fosforico, fosfonato, fosfato, BF4- y PF6; con la condicion de que, (i)cuando dos grupos alquilo están presentes en el mismocarobno o nitrogeno, están enlazados opcionalmente para formar una estructura cíclica y (ii)el nitrogeno del anillo heteroarilo de R10, cuando está presente,