baber/WOPTO huggingface dataset:
Patent SG-11201807595P-A (SG)
Title: Powder dustiness evaluation method and powder dustiness evaluation device
Inventor: HORIUCHI TATSUYA
IPC: G01N15/00
Filed: 2017-04-14
Abstract: The present invention intends to provide a method by which the scattering property of a powder can be more clearly evaluated. There is provided a method for evaluating a scattering property of a powder, the method including dropping a powder to be evaluated onto a liquid placed in a box, thereby scattering the powder as dust in the box, and measuring a dust concentration in air in the box with a dust meter. There is also provided an apparatus for evaluating a scattering property of a powder, the apparatus including a box in which a liquid is to be placed, and a dust meter that measures a dust concentration in air in the box when the powder to be evaluated drops onto the liquid placed in the box and scatters as dust.
Patent SG-11201808622S-A (SG)
Title: Chimeric receptors to flt3 and methods of use thereof
Inventor: BAKKER ALICE
IPC: C07K14/725
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111010111111111110101101111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/173410 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C07K 16/28 (2006.01) C07K 14/725 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, C07K 14/705 (2006.01) A61K 39/00 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, PCT/US2017/025613 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 31 March 2017 (31.03.2017) ZA, ZM, ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/317,219 1 April 2016 (01.04.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: AMGEN INC. [US/US]; One Amgen Center LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Drive, Thousand Oaks, California 91320-1799 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventor: BAKKER, Alice; 1234 Bubb Road, Cupertino, GW, KM, ML, MR, NE, SN, TD, TG). California 95014 (US). Declarations under Rule 4.17: (74) Agent: KONG, Lawrence B.; 1120 Veterans Blvd., South — as to applicant's entitlement to apply for and be granted a San Francisco, California 94080 (US). patent (Rule 4.17(ii)) (81) Designated States (unless otherwise indicated, for every Published: kind of national protection available): AE, AG, AL, AM, with international search report (Art. 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Il © 11 7r M IN 11 IN 11 © (54) Title: CHIMERIC RECEPTORS TO FLT3 AND METHODS OF USE THEREOF el 0 (57) : Antigen binding molecules, chimeric receptors, and engineered immune cells to FLT3 are disclosed in accordance ,1 . with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the FLT3 antigen binding molecules and engineered immune cells.
Patent SG-11201903602R-A (SG)
Title: Use of beta-catenin as a biomarker for treating cancers using anti-dkk-1 antibody
Inventor: KAGEY MICHAEL
IPC: A61K31/337
Filed: 2017-10-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 03 May 2018 (03.05.2018) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C12Q 1/6886 (2018.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) (21) International Application Number: PCT/US2017/058555 (22) International Filing Date: 26 October 2017 (26.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/413,198 26 October 2016 (26.10.2016) US (71) Applicant: LEAP THERAPEUTICS, INC. [US/US]; 47 Thorndike Street, Suite B1-1, Cambridge, MA 02141 (US). (72) Inventors: KAGEY, Michael, H.; 28 Brand Street, Arling- ton, MA 02474 (US). SIRARD, Cynthia, A.; 47 Thorndike Street, Suite B1-1, Cambridge, MA 02141 (US). (74) Agent: ABELLEIRA, Susan, M. et al.; Foley Hoag LLP, Seaport West, 155 Seaport Blvd., Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 1-1 Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) N Published: with international search report (Art. 21(3)) co O (54) Title: USE OF BETA-CATENIN AS A BIOMARKER FOR TREATING CANCERS USING ANTI-DKK-1 ANTIBODY co (57) : A method of treating a cancer in a subject in need thereof is disclosed. The cancer can be an esophageal cancer, a O uterine cancer, a liver cancer, or a cholangiocarcinoma. The method comprises administering to the subject an effective amount of an anti-Dkk-1 antibody or antigen binding-fragment thereof, wherein the subject is determined to have a constitutively activating mutation C of the beta-catenin protein. ~~ll~~~~~~~~ 011101010VIIIOH olo omm olo mil mum ow (10) International Publication Number WO 2018/081437 Al
Patent ZA-9429-B (ZA)
Title: Pyrrolidine derivatives their preparation and medicaments containing them
Inventor: CAPET MARC
IPC: A61P25/30
Filed: 1994-01-04
Abstract: PCT No. PCT/FR94/00009 Sec. 371 Date Jun. 28, 1995 Sec. 102(e) Date Jun. 28, 1995 PCT Filed Jan. 3, 1994 PCT Pub. No. WO94/15915 PCT Pub. Date Jul. 21, 1994The present invention relates to derivatives of formula:    <IMAGE>  (I)  to their salts, to their preparation and to the medicaments containing them.
Patent HU-218844-B (HU)
Title: Olefin polymerization catalyst made from metallocene compound and alumoxane compound and process for making thereof
Inventor: ALBIZZATI ENRICO
IPC: C08F4/60
Filed: 1990-01-30
Abstract: Catalysts for the polymerization of olefins, comprising the product of the reaction between:     A) a cyclopentadienyl compound of Ti, Zr or Hf;   B) an alumoxane compound of formula: <CHEM> in which R<1>, R<2>, R<3>, R<4>, the same or different from each other, are alkyl, alkenyl or alkylaryl radicals having 2 to 20 carbon atoms. y
Patent HU-191022-B (HU)
Title: Composite tablet
Inventor: ULLMAN MICHAEL K
IPC: A61K9/20
Filed: 1980-03-03
Abstract: The invention disclosed provides a multi-fractionable tablet structure initially configurated in a unitary dosage while having readily severable sub-dosage units as components thereof. Score markings are positioned variously about the tablet such as along the top and bottom surfaces thereof. Additionally, score markings may appear along opposite vertical side surfaces of the tablet. Special placement of the score markings readily permits alternatively an accurate equal bisectional or trisectional fracture of the tablet as may be desired for patient consumption.
Patent HU-195423-B (HU)
Title: Process for preparing cosmetic compositions against pimples and comedos
Inventor: BIRNER TIBOR
IPC: A61K31/165
Filed: 1980-04-10
Abstract: The product comprises (%w/w): 1.5-2 of p-amino benzoic acid -(beta-diethyl-amino) ethyl ester hydrochloride in 60 v/v% ethyl alcohol and some conventional skin non-irritating fragrance, e.g. rosemary.
Patent YU-46334-B (YU)
Inventor: PFINGSTNER W
IPC: F27B15/00
Filed: 1988-04-27
Abstract: A granular, plastic, carbon-containing refractory composition keeping workable for at least two months after the date of supply, for the lining of vessels for liquid steel such as casting ladles and transport ladles, by way of ramming, slingering or vibrating, comprises a granulated refractory material such as sintered and/or fused magnesia, spinel, magnesium silicate, zircon, corundum, alumina or andalusite, 1 to 20 percent by weight of a solid carbon carrier in the form of graphite, carbon black, ground coke powder, crushed carbon electrodes or the like or mixtures thereof, and 2 to 7 percent by weight of a stable thermosetting synthetic resin free of hardener, preferably a phenolic resin of the type Novolak or a modified phenolic resin, which is either present in the solid state as a finely ground powder, possibly with 2 to 7 percent by weight of a plasticizer, or dissolved in a non-aqueous solvent. If required, the composition can also contain an antioxidant in the form or 1 to 7 percent by weight of a metal powder and/or finely ground carbide.
Patent ZA-84552-B (ZA)
Title: Epoxy compositions containing substituted diamine hardeners
Inventor: DOMEIER LINDA ANN
IPC: C08L1/00
Filed: 1984-01-24
Abstract: Described herein is a composition comprising a select group of substituted diamine hardeners and an expoxy resin containing two or more 1,2-epoxide groups per molecule. These compositions exhibit reduced moisture absorption, and controlled reactivity which comprises the processing characteristics of the composition.
Patent ZA-87255-B (ZA)
Title: Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension
Inventor: KWEE BOBBY LIEP SIANG
IPC: A61K31/557
Filed: 1987-01-14
Abstract: The invention relates to a pharmaceutical preparation for obtaining a highly viscose hydrogel or highly viscose suspension which is suitable to be introduced by means of an injection syringe into body cavities, and which hydrogel or suspension contains at least a drug, a polymer which is insoluble or sparingly soluble in water but has the capability of swelling in water and a watersoluble thickening agent in a relatively low quantity.
Patent ZA-93848-B (ZA)
Title: Method of and apparatus for dispensing batches of soap lather.
Inventor: MEYER PAUL
IPC: A47K/
Filed: 1993-02-08
Abstract: The dispenser incorporates a storage container (7) for the liquid soap, a foamer (21) mixing air with the soap, and a pump (35). Between the container and foamer is an equalising receptacle (13) containing a set quantity of soap and air. The foamer is connected by a soap inlet tube (16) to the equalising receptacle. The head room (45) above the soap in the equalising receptacle is connected to the pump via the liquid soap in the equalising receptacle into which protrudes a connecting pipe (11), the foamer is positioned on a support (14).
Patent ZA-94775-B (ZA)
Title: 2-(4(4-azolylbutyl)-1-piperazinyl)-5-hydroxy-pyrimidine derivatives their preparation and their application as medicinal products
Inventor: CONSTANSA JORDI FRIGOLA
IPC: C07D239/42
Filed: 1994-02-04
Abstract: 2-[4-(4-Azolylbutyl)-1-piperazinyl]pyrimidine derivatives, characterized in that they correspond to the general formula I <IMAGE> in which X2 represents a nitrogen atom or a C-R2 group, X4 represents a nitrogen atom or a C-R4 group and X5 represents a nitrogen atom or a C-R5 group, their process of preparation, their application as medicament and the pharmaceutical compositions comprising them.
Patent AT-402259-B (AT)
Title: Process for the production of a stable pharmaceutical product with a content of granulocyte colony stimulating factor
IPC: A61K47/42
Filed: 1987-07-14
Granted: 1997-03-25
Abstract: A process for the production of a stable pharmaceutical product with a content of granulocyte colony stimulating factor (G-CSF). G-CSF with a molecular weight of about 19,000 <IMAGE> 1000 is mixed with a pharmaceutically acceptable surfactant, a saccharide, a protein and a compound with a high molecular weight, the mixture is dissolved in a phosphate buffer, and the solution is sterilized and introduced into a pharmaceutical container and stored as stable solution product or freeze-dried product.
Patent AT-393023-B (AT)
Title: Heating system
IPC: F24H3/06
Filed: 1989-12-06
Granted: 1991-07-25
Abstract: A heating system has a heating boiler 1 which is located in a heating space 2 and to the flue-gas connection piece of which is connected a post-combustion chamber 7, the combustion space 6 of which runs approximately horizontally. Connected to this combustion space 6 are two lower flue-gas outlet pipes 11, 12 of essentially horizontal axis, which merge via bends 13, 14 into upper flue-gas outlet pipes 15, 16, likewise of approximately horizontal axis. At the end, these upper flue-gas outlet pipes 15, 16 are connected via a connecting pipe 26, from which an outlet connection piece 27 opening into the chimney branches off. The upper flue-gas outlet pipes 15, 16 are offset laterally outwards in relation to the lower flue-gas outlet pipes 11, 12, and between these upper flue-gas outlet pipes is located a boiler 17 for generating hot service water, this boiler therefore being arranged partially above the post-combustion chamber 7 and partially above the lower flue-gas outlet pipes 11, 12. <IMAGE>
Patent CH-613837-B (CH)
Inventor: BEGUIN PIERRE-ANDRE
IPC: G04C3/14
Filed: 1977-06-14
Abstract: An electronic watch with mechanical display is more easily altered or corrected by sharing the display driving tests among a plurality of duel rotation sense motors. Such an arrangement enables practicable obtaining of a perpetual calendar in such a watch. A first stepping motor drives the seconds and minutes displays Figure 1, and the second stepping motor drives the hours and calendar display. Drive signals for the motors are derived by respective frequency dividers from a crystal controlled oscillator. When setting, a selector 8 is operated to select the unit to be corrected and in response to operation of a switch 9 or 10 the appropriate motor is driven forward or backward at a slow or fast rate. Memory circuits enable automatic adjustment for the number of days in the current month. <IMAGE>
Patent DK-152303-B (DK)
Inventor: KORSGAARD VAGN
IPC: E04D13/16
Filed: 1986-03-21
Abstract: An underroof for a sloping exterior roof and comprising a moisture absorbing layer (1) which on both sides comprise spaced, substantially horizontal highly diffusion resistant zones (2, 3), the diffusion resistant zones (2) on the top side of the moisture absorbing layer (1) partly overlapping the diffusion resistant zones (3) on the underside and being water tightly connected with the diffusion resistant zones on the underside at their upper edges (4). The underroof is impermeable to water flowing along the top surface thereof but has a sufficiently high resistance to diffusion to prevent summer condensation. Furthermore, it is capable of absorbing and discharging condensate formed on its underside.
Patent DK-165235-B (DK)
Title: Device for transferring loads, especially for the rapid transfer of loads on pallets
Inventor: RAVEZ PIERRE
IPC: B65G/
Filed: 1987-09-14
Abstract: PCT No. PCT/FR87/00010 Sec. 371 Date Sep. 11, 1987 Sec. 102(e) Date Sep. 11, 1987 PCT Filed Jan. 13, 1987 PCT Pub. No. WO87/04140 PCT Pub. Date Jul. 16, 1987.A load transfer device for palletized loads including a superstructure supporting a movable assembly having a plurality of teeth, and a lifting assembly associated with the teeth to provide for rapid load transfer. The transfer device includes a sighting mechanism to control the alignment of the superstructure, lateral jacks to correct the alignment of the superstructure, and a central pivot which authorizes a transverse displacement of the superstructure and/or rotation in its plane.
Patent FI-68638-B (FI)
Inventor: TESCHNER ECKART
IPC: C08L61/10
Filed: 1979-12-11
Granted: 1985-06-28
Abstract: Process for the manufacture of an abrasive material comprising at least two binder layers formed from at least one aqueous resol I prepared from a monohydric phenol and formaldehyde (molar ratio of phenol to formaldehyde 1:(1.1 to 2.5)) by the application of a first binder layer onto a carrier material, scattering abrasive particles thereon, drying the covering layer in a horizontal dryer to displacement resistance and thereafter cooling with an air stream, application of a second binding agent layer and in similar manner to the first step, drying to imprint resistance and thereafter cooling, whereby the heating and cooling are each effected by means of an air stream through slit nozzles arranged transversely to the direction of travel of the abrasive web and, after loosely forming the product into a roll, final curing is effected on the product in roll form, the coated carrier material being conveyed at speeds above 5 m/min through the dryers which have well defined and individually controllable heating and cooling zones and the air stream has a velocity of 5 to 200 m/s at the nozzle outlets and a temperature of 20 to 300 DEG  C., the air being extracted through adjacent extraction nozzles.
Patent FI-78298-B (FI)
Inventor: HENNIGER PETER WOLFGANG
IPC: C07D499/00
Filed: 1983-04-18
Granted: 1989-03-31
Abstract: Preparation of penicillanic acid 1,1-dioxide-and derivatives thereof by debromination of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides. The debromination is effected in a water-containing medium by reduction with zinc in association with an acid having a pKa-value measured in water less than 3.5.
Patent FI-70279-B (FI)
Inventor: NILSSON SVEN-BERTIL
IPC: F16G3/00
Filed: 1984-02-29
Granted: 1986-02-28
Abstract: A device for joining together the two ends of belts, preferably belts intended to be used in fabrics or felts in papermaking machines. The belt is provided at its ends (10, 12) with loops (14) by means of which the belt ends are permanently joined together by introduction through said loops of a pintle wire (16). The belt ends are also provided with means for temporary joining together of the belt ends, said temporary joining means consisting of two hook members (18) of synethetic resin, each hook member comprising a flat portion formed at one of its ends with a U-shaped portion. The temporary joining means (18) preferably are arranged so as to ensure that the flat portion of one of said means will be placed underneath the permanent seam or joint, whereby said flat portion will serve as a support during the interconnection of the permanent joining means to form the permanent seam.
Patent FI-79635-B (FI)
Inventor: ESKELINEN PAAVO
IPC: A61B5/308
Filed: 1986-11-28
Granted: 1989-09-29
Abstract: PCT No. PCT/FI87/00158 Sec. 371 Date Jul. 20, 1989 Sec. 102(e) Date Jul. 20, 1989 PCT Filed Nov. 26, 1987 PCT Pub. No. WO88/04114 PCT Pub. Date Jun. 2, 1988.The invention relates to a signal-shaping network comprising a differential amplifier (G) having an output and an inverting (A) and a non-inverting (B) input between which a signal source (S) is connected. When a differential amplifier is used particularly for the measuring of very weak biosignals, interference signals may easily make the measuring completely impossible. In the signal-shaping network according to the invention, interferences have been eliminated in such a way that an integrating feedback circuit (1a; 1b) is connected between the output and one input of the differential amplifier (G) and/or a derivative feedback circuit (2a) is connected between the output and the other input of the differential amplifier. In this way an adaptive differential amplifier is achieved which attenuates slow interference signals and/or rapid interference signals.
Patent FI-90770-B (FI)
Inventor: SAWYER DAVID ALAN
IPC: A61K31/53
Filed: 1987-05-29
Granted: 1993-12-15
Abstract: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate is provided. This salt has high water solubility and thus advantageously allows parenteral administration in the form of a sterile aqueous solution suitable for injection.
Patent FI-94108-B (FI)
Inventor: ETZEL MARK R
IPC: B41M5/385
Filed: 1988-08-19
Granted: 1995-04-13
Abstract: A high resolution thermal imaging medium including a support web having an image forming surface of a material which may be temporarily liquified by heat and upon which is deposited a particulate or porous layer of an image forming substance which is wettable by the material during its liquified state.
Patent FI-103322-B (FI)
Inventor: VANNUS TOM H
IPC: G02B6/42
Filed: 1989-10-19
Granted: 1999-06-15
Abstract: The present invention comprises a first interconnect assembly and a second interconnect assembly which detachably connects to the first interconnect assembly. One of the interconnect assemblies includes a shutter for blocking an optical path. The first and second assemblies have surfaces which mechanically co-act to drive the shutter away from the optical path. An optical fiber is connected to one of these assemblies. In the preferred embodiment, the first assembly (13) forms a plug and the second assembly (15) forms an adapter, such as a socket. The socket assembly includes a shutter (183) which is spring-biased to a normally closed position. In this normally closed position, the shutter blocks passage of laser light to an optical fiber (79). The plug assembly includes an appendage (25) having a camming surface (73) which co-acts with a camming surface (142) on the socket assembly so as to drive the shutter to an open position which permits transmission of laser light to the optical fiber.
Patent FI-103110-B (FI)
Inventor: D SILVA THEMISTOCLES DAMASCENO
IPC: A01P7/00
Filed: 1990-03-01
Granted: 1999-04-30
Abstract: The invention describes novel 3-cyano-4-sulfenylated-5-alkoxy-1-arylpyrazoles of general formula(I)   <CHEM>  wherein typically preferred substituents are:  R is C1 to C4 alkyl fully substituted by halogen; R1 is C1 to C4 alkyl, C3 to C6 alkenyl and alkynyl or aralkyl (each of which may be optionally substituted), dialkylaminocarbonyl or a group -P(=X)(Oalkyl)(Salkyl) wherein X is oxygen or sulfur;  R2, R3, R5 and R6 are each hydrogen or halogen;  R4 is CF3, OCF3, SCF3, SOCF3, SO2CF3, OCHF2, halogen or alkyl; and  n is 0, 1 or 2. The invention further relates to intermediates and processes to make the compounds as well as to compositions thereof and to methods of control of arthopod (especially insect) nematode, helminth, and protozoan pests.
Patent FI-110124-B (FI)
Inventor: LAWLIS VIRGIL BRYAN
IPC: C07K14/41
Filed: 1991-02-15
Granted: 2002-11-29
Abstract: The invention includes novel fusion DNA sequences encoding fusion polypeptides which when expressed in a filamentous fungus result in increased levels of secretion of the desired polypeptide as compared to the expression and secretion of such polypeptides from filamentous fungi transformed with previously used DNA sequences. The fusion DNA sequences encode a fusion polypeptide comprising, from the amino to carboxyl-terminus, first, second, third and fourth amino acid sequences. The first DNA sequence encodes a signal peptide functional as a secretory sequence in a first filamentous fungus. The second DNA sequence encodes a secreted polypeptide or portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third DNA sequence encodes a cleavable linker polypeptide while the fourth DNA sequence encodes a desired polypeptide.