baber/WOPTO huggingface dataset:
Patent RU-2667622-C2 (RU)
Title: Способ хирургического лечения сквозных макулярных разрывов
Inventor: Petrachkov Denis Valerevich
IPC: A61F9/007
Filed: 2017-02-07
Granted: 2018-09-21
Abstract: Изобретение относится к области медицины, а именно к офтальмологии. Для хирургического лечения сквозного макулярного разрыва путем трехпортовой витрэктомии проводят формирование лоскута внутренней пограничной мембраны путем удаления ее фрагментов из макулярной области с сохранением интактного участка мембраны вокруг разрыва, отсепаровку и переворачивание лоскута по направлению от наружной границы к центру, введение в витреальную полость перфторорганического соединения с последующей заменой его и жидкости на воздух. При этом лоскут внутренней пограничной мембраны для укрывания разрыва формируют путем удаления пяти ее фрагментов; первые два фрагмента в виде лент шириной 0,2-0,4 мм и длиной 2,0-2,5 мм удаляют по направлению от периферии макулярной области к центру разрыва, заканчивая в 0,1-0,2 мм от края разрыва, при этом угол между ними, открытый в височную сторону глаза, составляет 70-80°; вторые два фрагмента мембраны удаляют во встречном направлении поочередно, начиная от дистальных концов первых удаленных фрагментов и двигаясь по окружности разрыва до их соединения; пятый фрагмент мембраны удаляют с темпоральной стороны движением по окружности, начиная от дистальных концов участков, которые сформировались при удалении первых двух фрагментов мембраны, таким образом окончательно формируя лоскут внутренней пограничной мембраны. До момента отсепаровки лоскута в витреальную полость вводят перфторорганическое соединение. С помощью аспирационной канюли с силиконовым наконечником выполняют удаление гелеобразной субстанции в просвете разрыва. При помощи вакуумной аспирации соединяют края разрыва. Лоскут аккуратно разглаживают с помощью пинцета, устраняя складки мембраны по его краю. Способ уменьшает риск операционных и послеоперационных осложнений, повышает эффективность лечения больных со сквозным макулярным разрывом. 1 пр.
Patent RU-2766486-C2 (RU)
Title: Device and method of separation and extraction of alloy components, in particular alloy of noble metals
Inventor: FAORO DZHOVANNI
IPC: F27D99/00
Filed: 2016-01-25
Granted: 2022-03-15
Abstract: FIELD: metallurgy. 
     SUBSTANCE: device comprises a high-vacuum chamber containing at least one crucible for alloy, which must be separated, at least one heating element located in use near the crucible, at least one condensation device which is turned in use to the upper crucible hole. At that, the condensation device includes at least one cold element and at least one deflecting element which is adapted to deflect the flow of gaseous substances obtained during melting and evaporation of the alloy in the direction of the cold element. 
     EFFECT: invention relates to method and device for separation and extraction of alloy components, particularly alloy of noble metals. 
     24 cl, 7 dwg
Patent RU-2754907-C2 (RU)
Title: Improved fragmentation shell and its manufacturing method
Inventor: MUSTER MIKHEL
IPC: F42B5/02
Filed: 2016-12-08
Granted: 2021-09-08
Abstract: FIELD: armament. 
     SUBSTANCE: group of inventions relates to armament, namely to a method for manufacturing a fragmentation shell, a fragmentation shell and application of a shell. The method for manufacturing the fragmentation shell is proposed, wherein the shell partially consists of specified segments, the distance between which does not exceed 100 mcm, and contains connecting jumpers between longitudinally and/or radially oriented segments following each other. The specified segments and jumpers are manufactured by means of additive technology so that the distance between segments does not exceed 100 mcm. Segments are partially connected by retention material together with the formation of the shell before it collides with the target. The fragmentation shell and its application as handgun ammunition, police ammunition, army small-caliber ammunition, hunting ammunition, mortar or artillery ammunition, as well as ammunition for shooting at underwater targets are also disclosed in the claim. 
     EFFECT: increased efficiency of shell application and optimization of its structure. 
     24 cl, 12 dwg
Patent RU-2736213-C2 (RU)
Inventor: FORTUNA DAMIANO
IPC: A61B6/03
Filed: 2017-01-27
Granted: 2020-11-12
Abstract: FIELD: medicine. 
     SUBSTANCE: in invention, X-ray imaging device having a longitudinal axis and having a gantry configured to perform an X-ray imaging and forming an area for the examination; carrying structure, on which gantry is installed; a mechanical manipulator configured to move the medical instrument relative to the region to be examined; wherein the bearing structure comprises a guide forming an axis of linear movement parallel to the longitudinal axis; and carriage, moving gantry and mechanical manipulator along axis of linear movement. 
     EFFECT: use of this invention improves spatial relationship between mechanical manipulator and visualization device. 
     13 cl, 13 dwg, 3 ex
Patent RU-2725873-C2 (RU)
Title: Способ получения 1-(3-гидрокси, 28-ацетоксилуп-20(29)-ен-30-ил)-пиридиний бромида и его применение в качестве средства с антибактериальной и противогрибковой активностью
Inventor: PARFENOVA LYUDMILA VYACHESLAVOVNA
IPC: A61K31/58
Filed: 2018-08-20
Granted: 2020-07-07
Abstract: Изобретение относится к 1-(3-гидрокси, 28-ацетоксилуп-20(29)-ен-30-ил)-пиридиний бромиду (1). Изобретение также относится к его способу получения и к применению. Технический результат: получено новое соединение 1-(3-гидрокси, 28-ацетоксилуп-20(29)-ен-30-ил)-пиридиний бромид, который обладает антибактериальной и противогрибковой активностью для борьбы с заболеваниями человека и животных, вызванными грамположительными бактериями  Staphylococcus aureus  и грамотрицательными штаммами  Pseudomonas aeruginosa ; а также грибами видов  Candida albicans  и  Cryptococcus neoformans var. grubii . 3 н.п. ф-лы, 2 табл, 1 пр.
Patent RU-2758238-C2 (RU)
Title: Effective and balanced bidirectional promoter
Inventor: WUNDERLICH KERSTIN
IPC: C12N15/63
Filed: 2017-05-11
Granted: 2021-10-26
Abstract: FIELD: biotechnology. 
     SUBSTANCE: invention relates to biotechnology and is a bidirectional promoter hCMV-CAG4, and recombinant vectors and a recombinant virus containing a bidirectional promoter hCMV-CAG4 functionally connected to the first transgene in one direction and to the second transgene in the opposite direction. The present invention also provides methods for the creation and use of such recombinant vectors and a recombinant virus. 
     EFFECT: invention allows inducing an immune response against at least two antigens. 
     17 cl, 5 dwg, 1 tbl, 4 ex
Patent RU-2736843-C2 (RU)
Title: Radiation-based skin treatment device
Inventor: VARGHESE BABU
IPC: A61B18/20
Filed: 2017-08-08
Granted: 2020-11-20
Abstract: FIELD: medical equipment. 
     SUBSTANCE: radiation-based skin treatment device comprises a laser radiation source to deliver a pulsed beam of radiation for skin treatment by laser-induced optical breakdown of hair or skin tissue. In one arrangement, the focusing system has a pre-focusing lens for increasing convergence of the incident radiation beam and a skin contact lens having convex radiation input and radiation output surfaces. Position of the focal spot is controlled by adjusting the gap between the pre-focusing lens and the skin contact lens. In another arrangement, an adjustable system of lenses takes place before the adjustable focusing system to provide compensation of aberration in the controlled focusing system. 
     EFFECT: radiation-based skin treatment device is disclosed. 
     10 cl, 7 dwg
Patent RU-2760877-C2 (RU)
Title: ANIMALS OTHER THAN HUMANS CHARACTERIZED IN EXPANSION OF HEXANUCLEOTIDE REPEATS AT LOCUS C9orf72
Inventor: HESLIN DAVID
IPC: C12N15/113
Filed: 2017-09-29
Granted: 2021-12-01
Abstract: FIELD: biotechnology. 
     SUBSTANCE: invention relates to the field of biotechnology, in particular to a rodent containing a sequence characterized in expansion of hexanucleotide repeats at endogen locus C9orf72, as well as to its cell, embryo and motor neuron. An immortalized cell line containing a sequence characterized in expansion of hexanucleotide repeats at endogen locus C9orf72 is also disclosed. The invention also relates to a method for obtaining the above-mentioned rodent, providing for modification of a rodent genome to contain a sequence characterized in expansion of hexanucleotide repeats at endogen locus C9orf72. 
     EFFECT: invention is effective for identification of a candidate therapeutic agent for the treatment of a disease or condition associated with the presence of the sequence characterized in expansion of hexanucleotide repeats. 
     52 cl, 12 dwg, 10 tbl, 5 ex
Patent RU-2748833-C2 (RU)
Inventor: ZHANG GUOBAO
IPC: A61P31/12
Filed: 2017-11-27
Granted: 2021-05-31
Abstract: Настоящее изобретение относится к новому производному пиразоло-гетероарила, представленному общей формулой (I), или его фармацевтически приемлемой соли, где кольцо A представляет собой фенил; G представляет собой N; X 1  представляет собой CH 2 ; L 1  выбран из группы, состоящей из -NR 4 -, -O-, -C(O)-, -N(R 4 )C(O)- и ковалентной связи; R 1  представляет собой C 1-6  алкил, где C 1-6  алкил необязательно замещен одним или более C 1-6  алкокси; R 2  представляет собой   водород или галоген; L 2  представляет собой CH 2 ; R 3  представляет собой 4-6-членную насыщенную моноциклическую группу, где один кольцевой атом представляет собой N; R 4  представляет собой водород; и n равно 0 или 1. Кроме того, изобретение относится к соединению, представленному общей формулой (I-C), или его фармацевтически приемлемой соли, где W представляет собой п-метоксибензил; Х представляет собой галоген; кольцо A представляет собой фенил; G представляет собой N; X 1  представляет собой CH 2 ; R 2  представляет собой водород или галоген; L 2  представляет собой CH 2 ; R 3  представляет собой 4-6-членную насыщенную моноциклическую группу, где один кольцевой атом представляет собой N; n равно 0 или 1, а также к соединению, представленному общей формулой (I-E), или его фармацевтически приемлемой соли, где W представляет собой п-метоксибензил; кольцо A представляет собой фенил; G представляет собой N; X 1  представляет собой CH 2 ; L 1  выбран из группы, состоящей из -NR 4 -, -O-, -C(O)-, -N(R 4 )C(O)- и ковалентной связи; R 1  представляет собой C 1-6  алкил, где C 1-6  алкил необязательно замещен одним или более C 1-6  алкокси; R 2  представляет собой водород или галоген; L 2  представляет собой CH 2 ; R 3  представляет собой 4-6-членную насыщенную моноциклическую группу, где один кольцевой атом представляет собой N, R 4  представляет собой водород; n равно 0 или 1. Кроме того, изобретение относится к способам получения представленных соединений, фармацевтической композиции, содержащей указанное производное, и его применению в качестве терапевтического агента, в частности в качестве агониста TLR7. Технический результат: получены и описаны новые соединения, которые могут найти свое применение в качестве терапевтического агента, в частности в качестве агониста TLR7. 8 н. и 8 з.п. ф-лы, 3 табл.
Patent RU-2763544-C2 (RU)
Title: Combination of mcl-1 inhibitor and taxane compound, their applications and pharmaceutical compositions
Inventor: PORTER Dejl
IPC: A61K31/519
Filed: 2018-01-05
Granted: 2021-12-30
Abstract: FIELD: medicine; pharmaceutics. 
     SUBSTANCE: first invention is a combination for the treatment of mammary gland cancer or lung cancer, containing: (a) MCL-1 inhibitor, which is (2 R )-2-{[(5 S     a   )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(5-fluorofuran-2-yl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[1-(2,2,2-trifluoroethyl)-1 H -pyrazol-5-yl]methoxy}phenyl)propanoic acid or (2 R )-2-{[(5 S     a   )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid, or their enantiomers, diastereoisomers, atropisomers or their addition salts with pharmaceutically acceptable acid or base, and (b) a taxane compound, which is paclitaxel or docetaxel, for simultaneous, sequential or separate use. The group of inventions also includes: the specified combination for the use for the treatment of mammary gland cancer or lung cancer; a pharmaceutical composition containing the specified combination with one or several pharmaceutically acceptable fillers; the use of the specified combination for the preparation of a drug for the treatment of mammary gland cancer or lung cancer; a drug separately or jointly containing the specified combination components; a method for the treatment of mammary gland cancer or lung cancer, including the injection of the specified combination; and a method for the sensitization of a patient, including the injection of the specified combination. 
     EFFECT: group of inventions provides for the synergetic action of the combination of MCL-1 inhibitor and taxane compound. 
     24 cl, 4 tbl, 9 ex
Patent RU-2770395-C2 (RU)
Inventor: IVOSEVIC MILAN
IPC: A61B5/15
Filed: 2017-08-23
Granted: 2022-04-15
Abstract: FIELD: medical technology.  
     SUBSTANCE: group of inventions relates to medical technology. The device for obtaining a blood sample contains a holder for receiving a sample source, and the holder has a section for receiving a finger, an activation section and a port. The lancet body is fixed with the possibility of removal inside the port, and the lancet body has an inlet and an inner part. The piercing element is designed to move between the position before activation, in which the piercing element is held in the inner part, and the piercing position, in which at least a section of the piercing element continues through the inlet part. The container is connected with the possibility of removal to the holder section. The container forms a collection cavity. A device for activating the device for obtaining a sample is disclosed.  
     EFFECT: distribution of the sample taken in a controlled manner, simplifying and eliminating the variability of the workflow.   
     28 cl, 31 dwg
Patent UA-53398-C2 (UA)
Title: System for automated control of a multi-cylinder diesel power
Inventor: FILIPOV ANATOLII ZAKHAROVYCH
IPC: F02D17/02
Filed: 2002-05-16
Abstract: A system for automated control of a multi-cylinder diesel power has a high pressure fuel pump, a mechanical centrifugal controller with a prism of corrector, nozzles of closed type, overflow electromagnetic valves installed on each section in the head of the fuel pump, sensors of angle pulses, of the first cylinder position, of determining the cylinder in which injection/injection omission is to take place, of the controller start, and an electronic block for switching off given working cycles.The electronic block for switching off given working cycles is connected to the sensors of the controller start, of angle pulses, of the first cylinder position, of determining the cylinder in which injection/injection omission is to take place, and provides automated control of the frequency of rotation by switching on/of working cycles depending on the outer loading.
Patent UA-72578-C2 (UA)
Title: Pharmaceutical composition comprising pemetrexed in combination with monothioglycerol, l-cysteine or thioglycolic acid
IPC: A61K31/19
Filed: 2001-01-23
Abstract: The present invention provides a pharmaceutical composition comprising pemetrexed; at least one antioxidant selected from the group consisting of monothioglycerol, L-cysteine, and thioglycolic acid; and a pharmaceutically acceptable excipient. The pharmaceutical formulation is suitable for liquid parenteral administration.
Patent UA-83026-C2 (UA)
Title: Coating material, use and method for application thereof
Inventor: BRUCKBAYER ALEXANDER
IPC: C09D195/00
Filed: 2004-02-24
Abstract: The invention relates to a coating material which reacts without any evaporation of the solvent and which is cured with evaporation of a maximum percentage of mass of water. Said coating material is made up of at least two components, the first component containing a 60 70% mixture of bitumen and water, amounting to 50 100% of the total percentage % of materials; 0 50% of the total percentage of synthetic latex or natural latex, polyvinylacetate or acrylate, paraffin or wax emulsion and 0 10% of the total percentage of a viscosity regulator, thixotroping additives and improved adhesive additives. The second component contains 50 % of the total percentage of filling material, 40 80% of the total percentage of softening, non-volatile oil and 0 10% of the total percentage of a viscosity regulator, dispersing aids and wetting agents for oily phases, and the first component and the second component are present, in a mixture ratio of 100: 10-50 percent by mass. Said coating materials can be used for insulating anti-humidity coatings on surfaces of all orientations and/or closing joints and gaps. The first and second components are separated from each other and are guided to a mixer and are mixed therein. The mixture of the components is sprayed onto the surface by a spray nozzle.
Patent UA-79532-C2 (UA)
Title: Receiver with an extended dynamic range designed for an over-the-horizon direction finder
Inventor: POKRYSHEVSKYI VIKTOR MYKHAILOV
IPC: G01S7/285
Filed: 2005-08-15
Abstract: The proposed receiver with an extended dynamic range designed for a over-the-horizon direction finder additionally contains a power divider, a signal input unit, a frequency converter, two intermediate-frequency signal amplifiers, two time delay elements, two inverters, and two control signal formers. The proposed receiver provides a possibility concurrently receive signals that correspond to different transhorizon paths.
Patent UA-84491-C2 (UA)
Title: Composition of alternative liquid plant fuel for the diesel engines
Inventor: ZDRAVKO BRONISLAV YOSYFOVYCH
IPC: C10L1/18
Filed: 2007-03-27
Abstract: The alternative liquid plant fuel for the diesel engines contains the wastes of alcohol production: the fraction of high fatty alcohols, purified by means of distillation - fusel oil in the amount of 20-80 volume percents, aliphatic alcohols with ethers and aldehides – the light fraction of ethyl alcohol in the amount of 20-80 volume percents, and possibly, methyl/ethyl ethers of high fatty acids of plant oils in the amount of 20-50 volume percents or other plant oil in the amount of 20-50 volume percents.
Patent UA-90593-C2 (UA)
Title: Method of creation of artwork of wall painting type on finishing material for any surface of room made in the form of painting and finishing material for any surface of room made in the form of painting with image of decorative interior wall painting
Inventor: NETESOV VADYM VOLODYMYROVYCH
IPC: B44C1/00
Filed: 2008-10-24
Abstract: A method of creation an artwork of wall painting type on finishing material for any surface of a room made in the form of painting, according to which a substrate made in the form of substances for finishing construction works is applied in a thin layer on a layer of flexible backing in the form of a flexible fabric, and then it is subject to heat treatment up to formation of very fine cracks on the substrate, then on the substrate with fine cracks dyes are applied and/or liquid that can provide a transparent, brilliant, water-resistant film after drying in a thin layer. As dyes natural water-based coloured pigments are used, which are applied on the dry cracked substrate by hand and/or using special large-format printing equipment, or on the wet substrate, with formation of cracks on the substrate. A finishing material for any surface of the room is made in the form of painting depicting the decorative interior wall-painting, has a substrate made in the form of a flexible fabric applied on its substrate made in the form of substances for finishing construction works, on which, in turn, a layer of dye is applied and/or liquid capable of providing a transparent, shining water-resistant film after drying in a thin layer. In the case, at least one of the layers is applied with possibility of formation of very fine cracks on the substrate. As dyes natural coloured water-based pigments are used, which are applied on the dry cracked or on wet substrate, manually and/or using special large-format printing equipment. In the case the finishing material for any surface of a room, in the form of painting depicting the decorative interior wall-painting, is 0.5-2 mm thick, which ensures its flexibility.
Patent UA-104761-C2 (UA)
Title: Method for redundant measurements of nanoobjects linear dimensions
Inventor: KONDRATOV VLADYSLAV TYMOFIIOVYCH
IPC: G01B11/00
Filed: 2012-01-10
Abstract: The invention relates to measurement technique and can be used at development of high-accuracy measuring devices for measurement of linear dimensions of nanoobjects. A method of redundant measurements of linear dimensions of the nanoobject where first needle of cantilever is brought to the initial point of the nanoobject, with installation of ninety-degree phase shiftbetween the first and the second coherent fluxes of optical radiation, with delay of the first flux of optical radiation by timecorresponding to phase shift, with non-linear addition of the shifted by phase byfirst and second fluxes of optical radiation, with transformation of the first total flux of optical radiation to voltage, this includes information on phase shift, with measurement of voltageand with remembering its value. Then the second flux of optical radiation is delayed by the same time, corresponding to phase shift, with non-linear addition of shifted by phase byfirst and second fluxes of optical radiation, with transformation of the second total flux of optical radiation to voltage, this includes information on the phase shift, with measurement of voltageand with remembering its value. The ninety-degree phase shiftbetween the coherent fluxes of optical radiation is excluded, with installation of the needle of the cantilever with mirror to the end point of the nanoobject, thus at distancefrom the initial point that corresponds to introduction of phase shiftbetween the first and the second coherent fluxes of optical radiation. The first flux of optical radiation is delayed by timecorresponding to the phase shift, with non-linear addition of shifted by phase byfirst and second fluxes of optical radiation. The third total flux of optical radiation is transformed to voltage, this carries information on the phase shift, with measurement of voltageand with remembering its value. The second flux of optical radiation is delayed by the same time, corresponding to the phase shift, with non-linear addition of shifted by phase byfirst and second fluxes of optical radiation, with transformation of the fourth total flux of optical radiation to voltage, this includes information on phase shift, with measurement of the voltageobtained and with storage of its value, and on the real value of the linear dimension of the nanoobject conclusion is made by the equation of redundant measurements obtained before. The invention provides automatic exclusion of systematic errors of measurement, and at multiple measurements it decreases the random component of error as well.