baber/WOPTO huggingface dataset:
Patent SI-1594964-T1 (SI)
Title: Oligonucleotides which inhibit the expression of the ob-rgrp protein and method for detection of compounds modifying the interaction between the proteins of the ob-rgrp family and the leptin receptor
Inventor: JOCKERS RALF
IPC: C12Q1/68
Filed: 2004-02-09
Abstract: Oligonucleotides (ON), optionally modified and comprising 8-50 nucleotides (nt), that hybridize specifically to a 648 base pair (bp) sequence (1), given in the specification, and that inhibit expression of the leptin receptor related protein (OB-RGRP), are new. Independent claims are also included for the following: (1) interfering RNA (iRNA) of 15-25 nt that hybridize specifically with a 1114 bp sequence (21), reproduced, and inhibit expression of OB-RGRP; (2) vector that expresses ON or iRNA; (3) cell containing the vector of (2); (4) pharmaceutical composition containing ON, iRNA, the vector of (2) or the cell of (3); (5) fusion protein (FP) comprising a sequence with at least 65% identify with sequences (4) or (16), both of 131 amino acids (aa), or a substantial part of them, and a protein that is a donor or acceptor of energy, or a substantial part of it; (6) nucleic acid (I) that encodes FP; (7) nucleic acid with at least 65% identity with (I) or that hybridizes to it under stringent conditions; (8) cells that contain (I), or express FP, also their fragments, lysates and membranes; (9) methods for determining modified interaction between (4) or (13), or their homologs with at least 65% identity, and the leptin receptor; and (10) method for screening or detecting compounds that can be used to prevent or treat leptin-related disorders. ACTIVITY : Osteopathic; Anorectic; Antidiabetic; Cytostatic; Antiinflammatory; Immunomodulatory; Anabolic; Endocrine-Gen.; Antianemic; Antiangiogenic. MECHANISM OF ACTION : Inhibiting expression of OB-RGRP. HeLa cells were transformed with a vector that expressed the leptin receptor (OB-R) and a reporter gene (STAT3) and with an antisense agent, AS14, directed specifically against the OB-R related protein 3'-(triethylene glycol)-TGtAcAcGtGtAcGCcGtAa (AS14) (upper case indicates phosphorothioate; the five bases at each end are 2'-O-methylated). In absence of AS14, STAT3 activity was increased by 50% in presence of leptin, but in presence of AS14, leptin almost doubled STAT3 activity.
Patent SI-3042901-T1 (SI)
Title: Hepatitis c virus inhibitors
Inventor: BACHAND CAROL
IPC: C07D403/00
Filed: 2007-08-09
Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
Patent TR-200001975-T1 (TR)
Inventor: WENDT ALAN C
IPC: E04B9/06
Filed: 1999-09-16
Abstract: A drywall suspension grid system comprising a selection of various sized and specified pre-formed and pre-engineered "T" grid beams and components used to construct a grid having a grid face upon which drywall is mounted, thus creating a suspended drywall ceiling. The suspension grid system can be used to create flat ceilings, curved ceilings, soffits, fascia for floating edge ceilings, utility interfaces, or any combination thereof in a suspended grid drywall ceiling.
Patent DE-3689867-T2 (DE)
Inventor: LACINY RICHARD WENCESLAS
IPC: F41G3/26
Filed: 1986-03-24
Granted: 1994-09-08
Abstract: In a weapons training simulator, laser radiation is output via optics (28) to simulate the firing of a round, and reflected radiation received via a conjugate path to assess the effectiveness of the shot. In the event of a miss a scan of the target area is required to provide fall of shot information. The scan is performed by controlled movement of the output faces of fibre optics (23, 24, 25) flexibly coupling to fixed sources (20, 21. 22) and of the input face of a fibre optic (200) flexibly coupling to a fixed detector (201). The problem of the bulk and inertia of prior art systems is improved by the remote location of lasers, drive and control, which may be conveniently separated for service or replacement without disturbing the optically aligned input and output faces. A further improvement is that vertically aligned multiple sources may be employed without undue weight penalty, yielding elevation information from a lateral scan.
Patent DE-3779811-T2 (DE)
Inventor: KATZENSTEIN HENRY S
IPC: G06K19/06
Filed: 1987-03-12
Granted: 1992-12-24
Abstract: A reader identifies information, such as the identity of an object at a transponder, provided in binary form by the transponder. The reader initially generates a pulse which activates the transponder into transmitting a series of signals, such as by magnetic induction, to the reader. Upon each count of a particular number of signals in the reader, the reader generates an additional pulse which causes the transponder to transmit a new series of signals to the reader. The generation of the pulses by the reader may occur through the charge and discharge of energy in a storage member such as a capacitance. The series of signals produced by the transponder may have either a first frequency or a second frequency. The signals may be generated in each sequence at the first and second frequencies in an order dependent upon (a) the binary code identifying the object at the transponder and (b) the polarity of the pulse produced by the transponder in such sequence. The signals may be generated at the second frequency by connecting a capacitance across a coupling coil at the transponder. The reader then identifies the information by demodulating the signals received by it at the first and second frequencies. The reader is able to interrupt at any time the generation of the sequences of signals at the transponder when it does not receive the signals transmitted by the transponder. The reader then operates on a free running basis to generate pulses of opposite polarity at a relatively low frequency. In this way, the reader is constantly prepared to activate the transponder when the transponder becomes subsequently disposed within the effective range of the reader.
Patent DE-3786766-T2 (DE)
Inventor: BECKER MOLLIE M
IPC: A61F13/15
Filed: 1987-12-22
Granted: 1994-02-10
Abstract: The invention provides a pad (12) having a flow zone control layer (28) adjacent the bodyside liner (14) of the pad. The flow zone control layer (28) is in contact with the absorbent (30) on its lower side and the inner surface of the bodyside liner (14) on the upper surface. The flow zone control member (28) is located only in the middle portion of the pad (12). The bodyside liner (14) is provided with perforations in the area (16) of the flow zone control layer (28) to aid in transfer of liquids to the flow zone control layer (28). The pad (12) as is conventional would be provided with an impervious backing member (22) on the side away from the body. The preferred flow zone material is a meltblown polymer and the preferred perforated cover is spunbonded polypropylene.
Patent DE-3850093-T2 (DE)
Inventor: DAVEY CHERYL
IPC: C12Q1/68
Filed: 1988-08-26
Granted: 1994-11-03
Abstract: This invention relates to a process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The amplification process may be used to increase the quantity of the specific nucleic acid sequence to allow detection, or to increase the purity of the specific nucleic acid sequence as a substitute for conventional cloning methodology.
Patent DE-3856323-T2 (DE)
Inventor: PARSY ROLAND
IPC: C08F26/10
Filed: 1988-05-24
Granted: 1999-09-23
Abstract: Compatibilising agent for at least two incompatible thermoplastic polymers, characterised by a di- or triblock copolymer consisting of at least one N-vinylpyrrolidone or methyl (meth)acrylate telomer and of a mono or difunctional oligomer of an ethylenically unsaturated polymerisable monomer or of a polycondensable monomer or of a lactam. 
<??>It is prepared by condensation of the telomer with the oligomer. 
<??>It is employed in the manufacture of alloys of incompatible thermoplastic polymers.
Patent DE-3880142-T2 (DE)
Inventor: MIRLIEB BERND
IPC: G03B42/02
Filed: 1988-05-09
Granted: 1993-10-28
Abstract: PCT No. PCT/EP88/00403 Sec. 371 Date Nov. 8, 1989 Sec. 102(e) Date Nov. 8, 1989 PCT Filed May 9, 1988 PCT Pub. No. WO88/09002 PCT Pub. Date Nov. 17, 1988.In a device for holding down the lower cassette portion (19a) of an X-ray film cassette which is located in a cassette unloading and reloading apparatus, a hold-down lever (20, 21) is mounted to each of two parallely guided bars (10, 12) movable towards and away from each other respectively, said hold-down lever being pivotable into, and out of the transport path of the X-ray film cassette to accurately position said cassette. Each hold-down lever (20, 21) comprises a control arm (20a, 21a) resting against each of the two side walls (19d, 19e) of the upper cassette portion (19c). Since the control arms (20a, 21a) are upwardly inclined such that they form control surfaces facing the side walls (19d, 19e) of the upper cassette portion (19c), the hold-down levers (20, 21) are held in engagement with the lower cassette portion (19a) when the upper cassette portion (19c) is in its open position and are disengaged from the lower cassette portion (19a) when the upper cassette portion (19c) is in its closed position.
Patent DE-3880764-T2 (DE)
Inventor: DANDY III WALTER
IPC: A63C9/00
Filed: 1988-02-22
Granted: 1993-12-09
Abstract: A ski assembly and method of use are provided for shifting the upper body weight of a skier from the skier's legs to the skier's skis and ski boots to reduce the strain on the legs of the skier.
Patent TR-199801316-T2 (TR)
Inventor: AGREN LENNART
IPC: B29C57/02
Filed: 1997-01-13
Abstract: Method for renovation of pipelines, comprising introduction of a lining pipe into an existing pipeline, said lining pipe having a length corresponding to the length to be renovated, and consisting of a fusible polymer in a folded condition and unfolding of the lining pipe in order to line the pipeline. The lining pipe is built up by introducing lining layer (1, 4, 5, 6, 7, 8, 9) into the pipeline to be lined, which layers are pressurised and successively fused together by subjecting each layer (1, 4-9) to fusion heat from a heat-source (3), which is carried along the inside of the innermost layer of lining built up so far.
Patent TR-199801640-T2 (TR)
Inventor: LEE SUNGGYU
IPC: C01B11/02
Filed: 1997-02-21
Abstract: A method of forming an aqueous chlorine dioxide solution is disclosed which includes reacting in a reaction vessel an acid reaction solution containing a hydroxy carboxylic acid and a companion acid with an alkali metal salt of a chlorite ion. In accordance with the process, the hydroxy carboxylic acid serves to temporarily transfer chlorine from and does not form a salt with the alkali metal salt of a chlorite ion. The aqueous chlorine dioxide solution produced is substantially free of chlorous acid and preferably is free of other by-products such as sodium chloride and free chlorine. The method further includes maintaining the reaction vessel at a pH of less than 5 and/or withdrawing at least a portion of the chlorine dioxide from the aqueous chlorine dioxide solution. The method enables rapid, efficient, compact and safe generation of chlorine dioxide. A method of disinfecting water, and apparatus for making chlorine dioxide and for disinfecting water also are provided.
Patent TR-199802209-T2 (TR)
Inventor: MEYDEN HENDRIKUS JOHANNES VAN
IPC: A61M5/32
Filed: 1997-05-06
Abstract: Emniyetli siringa, bir tüp haznesinde (1), piston gövdesi (2) ve piston basi (3) ile bir pistona, ve piston tutma formasyonlarini koruyucu bir kilifa (4) sahiptir. Bir sivi yolu bas (3) ve gövde (2) boyunca uzanir ve gövde (2) kilif (4) içinde boyuna sekilde yerlestirilebilir; kilif (4) disindaki bas (3) ile piston tutma formasyonlari yoluyla tutturulur ve sivi içerisinde gövde (2) ile temas edecek biçimde baglanir. Tüp haznesi (1) piston tutma formasyonlarini açiga çikarmak ve açiga çikan pistonu kavramak için bosaltim pozisyonundaki bas (3) ve kilif (4) üzerinde kayabilir, tüp haznesi açiga çikan pistonu çekmek için bosaltim pozisyonundan esasen kiliftan emniyetli olarak kilitlenmis bir pozisyona kaydirilabilir.
Patent TR-199902024-T2 (TR)
Inventor: METCALF STEPHEN C
IPC: B26B21/16
Filed: 1998-02-18
Abstract: Tiras biçagi kartuslari için mandallar içeren bir kartus sunucusu. Mandallar, sap kartusa dogru hareket ettirildiginde kartuslari sap üzerindeki sap baglanti yapisina baglanmalarina izin veren önceden belirlenmis konumlarda tutar. Her mandal, ilgili sap baglanti yapisiyla etkilesime girmek için sekillendirilen ve konuslandirilan mandal kam yapisina haizdir. Böylece mandal, sap bir kartusun kartus baglanti yapisina dogru hareket ettirildiginde ve ona baglandiginda kivrilir ve bir kartusu mandallanmamis bir konuma iter. Ürün sunucu, tabandan uzanan, büyük ölçüde tabana dik olan jilet birimi ayiricilarina da haizdir ve jilet birimi ayiricilari içine jilet birimlerinin girdigi jilet birimi bölgeleri tanimlar.
Patent DE-60000197-T2 (DE)
Inventor: SANSON PASCALE
IPC: G09F3/03
Filed: 2000-10-18
Granted: 2002-12-12
Abstract: The method of attaching a ticket to an article of merchandise involves sliding a tubular ticket carrier (1) onto a cord (2) and forming it into a loop. The ends of the loop are placed into a clip which is then pressed around them to retain them and the tubular carrier together. The cord can be cut simultaneously with the clipping operation.
Patent DE-60000989-T2 (DE)
Inventor: LAFAILLE MARIA
IPC: B41M1/02
Filed: 2000-04-04
Granted: 2003-11-13
Abstract: A method for printing an image onto an object including applying printing ink to a carrier element constructed of a flexible layer-shaped material and in communication with a pressing device having an internal region which can be pressurized with a fluid, positioning the carrier element and the object in contact with one another without substantially increasing the internal pressure of the pressing device and then causing a substantial increase of pressure in the internal region of the pressing device whereby a portion of the carrier element is urged to further extend around the object. The carrier element is stretched at least during the step of applying the printing ink.
Patent DE-60001317-T2 (DE)
Inventor: VAINIO TOMMI
IPC: B29C48/94
Filed: 2000-06-07
Granted: 2003-10-30
Abstract: The invention relates to a rotating nozzle structure of an extruder which comprises a rotatable nozzle, a die, which rests against the extruder frame and which comprises an annular front surface on the nozzle side, and a sealing plate, which is arranged between the front surface of the die and the nozzle and pressed tightly against the sealing surface of the nozzle to seal the nozzle with respect to the die. According to the invention, the die is arranged to slide in the axial direction with respect to the extruder frame and comprises a flow channel, which is under pressure of the material to be extruded and tapers conically towards the nozzle, and that the ratio of the area (Atiiv) of the die's annular front surface to the area (Aproj) of the projection surface of the flow channel's conical section is between 0.1 and 10.
Patent DE-60001394-T2 (DE)
Inventor: WITT W
IPC: B07B1/20
Filed: 2000-03-10
Granted: 2003-10-09
Abstract: A particle size classifier in which feed material composed of product and overs moves downwardly through a separator unit by the action of negative pressures created by a first air blower associated with the collection of product and a second air blower associated with the collection of overs. As the feed material moves downwardly, the product and the overs are separated with the product passing from within a screen unit to outside the screen unit and the screen unit preventing passage of the overs. Blowback air, applied to the screen unit from the outside cleans the cylindrical screen unit to permit continued passage of product through the screen unit.
Patent DE-60002535-T2 (DE)
Inventor: EGASHIRA NORIO
IPC: A63F13/812
Filed: 2000-01-27
Granted: 2003-11-20
Abstract: A lever 11 is an analog lever and can point to any directions within a two- dimensional plane. The content instructed by operating the lever 11 includes a direction associated with various movements which an object of operation performs, for example, a moving direction of an operated player or a fly direction of a kicked ball. The content operated by a kick input part 12 mainly includes instructions of a start of movements such as a pass, a shot and a sliding tackle made by the operated player, adjustment of a speed of the ball kicked by a pass or a shot, adjustment of an angle of elevation in kicking up a loop shot or a fly ball. A speed sensor is provided in the kick input part 12 and a speed in kicking the kick input part 12 is detected by this speed sensor. Most of operations can be performed by only the lever 11 and the kick input part 12.  <IMAGE>
Patent DE-60003960-T2 (DE)
Inventor: MORIMOTO SHIN ICHI
IPC: A01K89/0155
Filed: 2000-02-23
Granted: 2004-04-22
Abstract: A centrifugal braking mechanism is a device for braking a spool (12) that is rotatably supported in a reel body (1). The braking mechanism uses centrifugal forces in order to produce braking force against rotation of the spool (12). The braking mechanism (23) includes a plurality of brake members (53), a brake housing (52) having a cylindrically shaped brake liner, and an adjusting mechanism. Each of the plurality of brake members (53) is configured to move in a radially outward direction relative to the spool in response to rotation of the spool (12). The brake housing (52) and brake liner (57) are moveable in an axial direction relative to the spool (12) and brake members (53) such that any selected number of the brake members (53) may contact the brake liner to generate the braking force. The adjusting mechanism is used to selectively move the brake housing (52) and brake liner (57) into any of a plurality of axial positions thereby determining the number of brake members (53) that are contactable with the brake liner (57) in response to centrifugal force. The level of braking force desired is determined by the number of brake members (53) that may contact the brake liner (57). <IMAGE>
Patent DE-60007703-T2 (DE)
Inventor: MATSUNAMI TOSHIHARU
IPC: E02F3/32
Filed: 2000-10-05
Granted: 2004-12-02
Abstract: There are provided a excavator body, a cabin provided on the upper surface, a work attachment mounted on the front part of said excavator body, and railings and roof supports forward of the cabin and rearward of a boom constituting the work attachment, the boom being arranged not to interfere with the roof supports in the whole rising and falling operating range over the whole swing operating range. Thereby, the maximum stand-up angle of he boom is enlarged to a specification angle, and the minimum rotating radius of the upper construction body including the work attachment is reduced to secure necessary railing function, enabling installation of a roof naturally in a minimum space. <IMAGE>
Patent DE-60008120-T2 (DE)
Inventor: SAVILLE PATON
IPC: F16C27/02
Filed: 2000-08-24
Granted: 2004-08-26
Abstract: An improved foil thrust bearing includes a pair of members arranged for relative rotation with respect to one another. One of the pair of members is adapted to rotatably support the other. A thrust bearing disk is operatively disposed between the pair of relatively rotatable members. The thrust bearing disk has a plurality of diverging surface ramps. The surface ramps can comprise an inner ramp and an outer ramp. The thrust bearing disk can also comprise a plurality of radial slots. A plurality of separately formed, converging surface compliant foils are disposed on the thrust bearing disk and between the ramps. An underspring element is operatively disposed between the thrust bearing disk and one of the rotatable members, with the underspring element having a plurality of alternating upper and lower ridges.
Patent DE-60009713-T2 (DE)
Inventor: MAERZ ANDREAS
IPC: A23L3/10
Filed: 2000-10-25
Granted: 2005-04-07
Abstract: This invention is related to methods for inactivating microorganisms using high pressure processing. A method is described for inactivating microorganisms in a product using high pressure processing comprising the steps of packing said product in a flexible container, heating said product to a pre-pressurised temperature, subjecting said product to a pressure at a pressurised temperature for a time period; and reducing the pressure after said time period. The method of the present invention could further comprise an additional step of subjecting said product to a predetermined amount of oxygen for a time interval The methods of the present invention may be applied preferably to food, cosmetic or pharmaceutical products. <IMAGE>
Patent DE-60011203-T2 (DE)
Inventor: LORANT RALUCA
IPC: A61Q1/10
Filed: 2000-08-28
Granted: 2005-08-25
Abstract: Water-in-oil emulsion comprises: (1) at least one alkyl polyglycoside with HLB (hydrophilic/lipophilic balance) below 7 (preferably up to 5); and (2) at least one volatile oil. The amount of alkyl polyglycoside(s) is 0.1-10 wt.% (per active matter) and the content of oil phase is 5-50 wt.%, per total wt. of emulsion. Alkyl polyglycoside can be used in mixture with 14-24C branched and/or unsaturated fatty alcohol, used in amount 60-90 wt.% of alkyl polyglycoside/fatty alcohol mixture. Emulsion preferably also contains at least one filler, in amount 0.01-15 wt.% per total wt. of emulsion, and constitutes cosmetic composition. Independent claims are also included for: (1) the use of emulsion as claimed in cosmetics, for treatment, protection, care, make-up removal and/or cleaning of skin, lips and/or hair, and/or for make-up of skin and/or lips; (2) process of cosmetic treatment of skin, hair and/or lips, comprising application of emulsion as claimed; and (3) use of emulsion as claimed in preparation of cosmetic composition for treating dry and/or sensitive skin and dry lips.
Patent DE-60017688-T2 (DE)
Inventor: NAOKI SUGIMOTO
IPC: C03C13/04
Filed: 2000-11-24
Granted: 2005-12-22
Abstract: A glass fiber comprising core glass and clad glass, wherein the core glass consists essentially of from 25 to 70 mol% of Bi2O3, from 5 to 74.89 mol% of B2O3+SiO2, from 0.1 to 30 mol% of Al2O3+Ga2O3, and from 0 to 10 mol% of CeO2. <IMAGE>
Patent DE-60018422-T2 (DE)
Inventor: DORMER ROBERT LESLIE
IPC: A61K31/52
Filed: 2000-04-20
Granted: 2006-04-06
Abstract: The use of a type V cyclic nucleotide phosphodiesterase inhibitor for the preparation of a medicament for the treatment of cystic fibrosis.