Patent EA-000790-B1 (EA)
Title: Composition for use in ophthalmologic surgery and method therefor
Inventor: GALIN MILES A
IPC: A61K31/221
Filed: 1996-04-18
Abstract: 1. A composition for use in ophthalmologic surgery comprising a viscoelastic polymer and an agent selected from the group consisting of miotic agents and mydriatic agents. 2. The composition of claim 1, wherein the viscoelastic polymer is hyaluronic acid and the agent is atropine. 3. The composition of claim 1, wherein the viscoelastic polymer is hyaluronic acid and the agent is pilocarpine. 4. The composition of claim l, wherein the viscoelastic polymer is hyaluronic acid and the agent is phenylephrine. 5. The composition of claim 1, wherein the viscoelastic polymer is hyaluronic acid and the agent is isopilocarpine. 6. The composition of claim 1, wherein the viscoelastic polymer and the agent are comprised in a complex, wherein the complex is acetylcholine hyaluronate. 7. The composition of claim I comprising an anionic viscoelastic polymer and a cationic agent selected from the group consisting of miotic agents and mydriatic agents. 8. The composition of claim 7, wherein the viscoelastic polymer is sodium hyaluronate and the agent is atropine sulfate. 9. The composition of claim 7, wherein the viscoelastic polymer is chondroitin sulfate and the agent is pilocarpine hydrochloride. 10. The composition of claim 7, wherein the viscoelastic polymer is sodium hyaluronate and the agent is phenylephrine hydrochloride. 11. The composition of claim 7, wherein the viscoelastic polymer is sodium hyaluronate and the agent is acetylcholine chloride. 12. The composition of claim 7, wherein the viscoelastic polymer is sodium hyaluronate and the agent is pilocarpine hydrochloride. 13. The composition of claim 7, wherein the viscoelastic polymer is sodium hyaluronate and the agent is isopilocarpine hydrochloride. 14. A medicament composition comprising biodegradable micro capsules which comprise an agent selected from the group consisting of miotic agents and mydriatic agents. 15. The medicament composition according to claim 14 wherein the microcapsules are constructed of polylactide. 16. The medicament composition according to claim 14 where the microcapsules are constructed of co-poly(lactideglycolide). 17. The medicament composition according to claim 14 which further comprises a viscoelastic polymer. 18. The medicament composition comprising soluble copolymer micelles comprising an agent selected from the group consisting of miotic agents and mydriatic agents, wherein the micelles comprise a hydrophilic and a hydrophobic portion, and the agent is absorbed into the hydrophobia portion of the copolvmer micelle. 19. The composition according to claim 18, wherein the micelle comprises ethylene oxide-propylene oxide-ethylene oxide block copolymer. 20. The composition according to claim 19, wherein the micelle further comprises phenylephrine. 21. The composition according to claim 18, which further comprises a viscoelastic polymer. 22. A method of maintaining the structural integrity of the anterior chamber of the eye during surgery whilst concurrently maintaining the desired pupil size, comprising administering the composition of any one of claims 1 or 21.