baber/WOPTO huggingface dataset:
Patent CA-2779070-A1 (CA)
Inventor: COHEN DANIEL
IPC: A61K31/343
Filed: 2010-10-29
Abstract: The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder.
Patent CA-2779179-A1 (CA)
Inventor: FISCHER MARK C
IPC: H02M7/06
Filed: 2012-06-05
Abstract: A linear transformer power supply is disclosed that extracts a high level of energy from a linear transformer during the full cycle of AC input voltage.
Patent CA-2780859-A1 (CA)
Title: Fty720 halogenated derivatives
Inventor: AUBERSON YVES
IPC: A61K31/135
Filed: 2010-12-08
Abstract: There is provided new iodo- or bromo-compounds and their use as diagnostic agents and imaging agents for diseases or disorders where S1P receptor expression is altered.
Patent CA-2782720-A1 (CA)
Title: Pyrrolo[2,3-d]pyrimidine compounds
Inventor: XIE JIN
IPC: A61K31/53
Filed: 2010-12-06
Abstract: Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation. (Formula (I))
Patent CA-2784689-A1 (CA)
Inventor: ESFAND ROSEITA
IPC: A61L29/08
Filed: 2010-12-20
Abstract: The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.
Patent CA-2786538-A1 (CA)
Title: Lancing device with improved guidance mechanism
Inventor: ROBBINS AVI M
IPC: A61B5/151
Filed: 2011-01-12
Abstract: A lancing device (10) having improved guidance features and a drive mechanism subassembly that is generically compatible with a variety of outer housing configurations, and an improved assembly method for fabricating a lancing device.
Patent CA-2787343-A1 (CA)
Inventor: KAYSER FRANK
IPC: A61P3/06
Filed: 2007-06-26
Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
Patent CA-2787726-A1 (CA)
Inventor: PEPLINSKI JAMES
IPC: H02J4/00
Filed: 2012-08-23
Abstract: Various embodiments provide safety disconnect systems for a power system. In one aspect, a safety disconnect system includes an enclosure operative to receive a plurality of input power lines into the enclosure and provide a plurality of output power lines out of the enclosure. Each input power line is coupled to and paired with a corresponding one of the output power lines, where each input power line and output power line is operative to provide power from a power source. A plurality of switches are provided in the enclosure, each of these switches coupled between an associated one of the pairs of input power line and output power line, and each switch operative to disconnect the associated input power line from the corresponding output power line.
Patent CA-2788677-A1 (CA)
Inventor: BLOT PHILIPPE
IPC: B29C45/00
Filed: 2012-08-30
Abstract: Un procédé de fabrication d'une structure, en particulier un fuselage d'aéronef en matériaux composites comprenant une peau (2) et des pièces profilées à section en V fixées sur la peau (2) appelées raidisseurs (4). Le procédé comprend une étape de positionnement de poinçons sur un mandrin afin de former des gorges entre les poinçons. Les gorges sont disposées selon au moins deux réseaux (6a, 6b, 6c), chaque gorge d'un même réseau (6a, 6b, 6c) rencontrant au moins une gorge d'un autre réseau en un noeud (8). Le procédé comprend également une étape de positionnement de préformes de raidisseurs dans les gorges de sorte que deux raidisseurs (4) au moins se rencontrent au niveau dudit noeud (8) et une étape d'injection de résine de manière à assembler les raidisseurs (4). On obtient ainsi une structure faite d'une seule pièce.
Patent CA-2792198-A1 (CA)
Title: Macrocyclic lactone derivatives for the treatment of cancer
Inventor: MOHAMMED ABDUL SHAFEE
IPC: C07D313/00
Filed: 2010-11-15
Abstract: The present invention provides compounds represented by formula (1): wherein, R1, R2, R3 and R4 are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable polymorphs and prodrugs. The invention also relates to processes for the manufacture of compounds of formula (1) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful for the treatment of cancer. The present invention further provides a method of treatment of cancer by administering a therapeutically effective amount of the said compound of formula (1) or its pharmaceutical composition, to a mammal in need thereof.
Patent CA-2793490-A1 (CA)
Inventor: WEINSCHENK TONI
IPC: G01N33/68
Filed: 2011-04-15
Abstract: The invention relates to a method for quantitatively identifying relevant HLA-bound peptide antigens from primary tissue specimens on a large scale without labeling approaches. This method can not only be used for the development of peptide vaccines, but is also highly valuable for a molecularly defined immunomonitoring and the identification of new antigens for any immunotherapeutic strategy in which HLA-restricted antigenic determinants function as targets, such as a variety of subunit vaccines or adoptive T-cell transfer approaches in cancer, or infectious and autoimmune diseases.
Patent CA-2794184-A1 (CA)
Inventor: SELLA YOAV
IPC: A61M1/06
Filed: 2011-03-10
Abstract: ABSTRACT The invention relates to an apparatus and method to determine and monitor the flow rates and volume of fluids excreted or secreted by the body. The invention achieves the above objects by providing an apparatus comprising; a measuring unit comprising a conduit made of a material having a low thermal conductivity and supporting at least two thermistors; an upstream thermistor serving as a compensation thermistor and a downstream thermistor located as far downstream as possible from said upstream thermistor and pre-heated to and kept at pre-defined temperature which is warmer than the fluid temperature to be metered; and means for applying small electric voltages to the thermistors to enable generation of an electric signal; and a control and display unit being operatively connected to the measuring unit.
Patent CA-2796312-A1 (CA)
Title: Anti-cd160 specific antibodies for the treatment of eye disorders based on neoangiogenesis
Inventor: LE BOUTEILLER PHILIPPE
IPC: A61K39/395
Filed: 2011-05-27
Abstract: The present invention relates to the use of at least one anti-CD 160 antibody, preferably a compound selected from CL1-R2 monoclonal antibody (which may be obtained by the hybridoma CNCM 1-3204), its conservative fragments and its conservative derivatives, for preparing a drug designed to treat neovascular eye diseases.
Patent CA-2798993-A1 (CA)
Inventor: KUO LAWRENCE L
IPC: C04B24/12
Filed: 2011-05-17
Abstract: The present invention discloses additive compositions, cementitious compositions, and methods for controlling air in cementitious compositions, wherein a polyalkoxylated polyalkylene polyamine defoamer is deployed in combination with one or more air-entraining agents, such as higher alkanolamines, water-reducing agents including oxyalkylene-containing superplasticizers, or other air entraining agents.
Patent CA-2801995-A1 (CA)
Title: A cartridge containing one or more beverage ingredients and a method of making a beverage using such a cartridge
Inventor: YORK GEOFFREY
IPC: A47J31/18
Filed: 2011-06-06
Abstract: A cartridge contains a beverage ingredient which comprises liquid beverage ingredient and elongate particles of beverage ingredient. The cartridge comprises an inlet (45) for the introduction of an aqueous medium, an outlet (44) for a beverage produced from the beverage ingredient, and a flow path linking the inlet to the outlet. The cartridge further comprises a filter (400) located in the flow path and an aperture (128) located in the flow path downstream of the filter, the aperture arranged, in use, to generate a jet of beverage. The filter has a plurality of openings (401) sized to retain a substantial portion of the elongate particles on the upstream side of the filter to prevent blockage of the aperture. The maximum area of each opening on the upstream face of the filter is no more than ten times the area of the aperture.
Patent CA-2802394-A1 (CA)
Title: Dispositif d'amenagement d'un vehicule
Inventor: PERAKIS PHILIPPE
IPC: B60R5/04
Filed: 2011-06-14
Abstract: La présente invention concerne un dispositif d'aménagement d'un véhicule, caractérisé en ce qu'il comporte au moins un caisson (11) formé d'au moins deux compartiments (12a, 12b), au moins l'un des compartiments (12a) étant fixe par rapport au véhicule et au moins l'un des compartiments (12b) étant mobile par rapport au compartiment fixe, en ce que le compartiment mobile (12b) est lié au compartiment fixe (12a) au moyen d'une fixation permettant un déplacement horizontal et vertical du compartiment mobile, cette fixation comportant au moins un bras (13) pivotant autour d'un axe (22, 22', 22") solidaire de l'un desdits compartiments fixe ou mobile, en ce que ledit au moins un bras (13) comporte en outre un doigt de guidage (23) agencé pour être guidé dans une rainure (21, 21', 21") réalisée dans le compartiment mobile ou fixe qui n'est pas solidaire de l'axe du bras, et en ce que ledit compartiment mobile peut être placé au moins dans une première position dans laquelle il est disposé au-dessus du compartiment fixe et dans une deuxième position dans laquelle il est placé à côté du compartiment fixe de telle façon que le haut du compartiment fixe et du compartiment mobile forment une surface sensiblement plane.
Patent CA-2804174-A1 (CA)
Title: Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
Inventor: JOHNSON BANKOLE A
IPC: G16B20/00
Filed: 2011-07-01
Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotoin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
Patent CA-2805981-A1 (CA)
Title: Method and apparatus for treating a contaminated solvent
Inventor: GOETHEER EARL LAWRENCE VINCENT
IPC: B01D53/62
Filed: 2011-06-08
Abstract: A method for treating a contaminated alkaline amino acid salt solution is provided. First, carbon dioxide is introduced into the amino acid salt solution, with the result that carbonate or carbonate salts is or are precipitated, these being filtered off. The remaining filtrate is then cooled, amino acid or amino acid salts being crystallized out and likewise being filtered off. The amino acid or amino acid salt is then dissolved again, with the result that a treated amino acid salt solution is recovered.
Patent CA-2809745-A1 (CA)
Title: Method for releasably holding a surgical instrument
Inventor: JENSEN JOEL F
IPC: A61B17/28
Filed: 1996-06-05
Abstract: The invention is directed to a method for releasably holding a surgical instrument having a shaft with a proximal end, a distal end and a mounting means affixed to and having a protrusion extending from the shaft between the proximal and distal ends. The method comprises the steps of providing an instrument support having a central bore and a first hole in communication with the bore, sliding the shaft through the bore of the support such that the protrusion slides through the first hole, aligning the protrusion with a second hole transverse to and in communication with the first hole, rotating the protrusion through the second hole and out of the first hole so as to prevent further axial movement of the shaft through the bore thereby coupling the instrument to the support. The method further includes providing an actuator driver having a central bore and a first hole in communication therewith and sliding a pair of actuator links laterally extending from the instrument shaft through the first hole. The method allows a surgeon to rapidly engage and disengage a surgical instrument from the instrument support during a surgical procedure, such as open surgery, laparoscopy or thoracoscopy.
Patent CA-2809898-A1 (CA)
Inventor: HANSEN LARS ELMEKILDE
IPC: C03B5/12
Filed: 2011-08-31
Abstract: The present invention concerns a method and an apparatus for the production of a mineral melt by burning combustible material in the presence of inorganic particulate material and thereby forming a melt, said apparatus comprising a circulating combustion chamber (1) having at least two inlets adapted to receive a supply of a fuel (2)f pre-heated mineral material (3) and a combustion gas (4), a heat exchange system for pre-heating mineral material comprising a first pre-heater cyclone (12), a conduit (11) from the circulating combustion chamber (1) to the first pre-heater cyclone (12) for transporting exhaust gases, a material inlet for injecting the material into the conduit (11), and a bottom cyclone outlet which is in flow communication with inlets in the circulating combustion chamber for feeding pre-heated mineral material to said combustion chamber; means for collecting a mineral melt (9), and wherein the outlet of said first pre-heater cyclone (12) is provided with means (40) for stabilising and splitting the mineral material flow into two material flows for feeding the at least two combustion chamber inlets.
Patent CA-2812715-A1 (CA)
Title: A stable sunscreen composition
Inventor: CHAVAN MOHAN VIJAYKUMAR
IPC: A61K8/37
Filed: 2011-10-04
Abstract: The present invention relates to a personal care composition, particularly, a stable sunscreen composition. The problem associated with a dibenzoylmethane sunscreen is its relatively unstable nature, especially in the presence of a UV-B sunscreen. There is a need for using more readily and easily available compound as a sunscreen stabilizer thereby ensuring reduced cost of such sunscreen compositions. The present inventors have worked intensively on solving this problem and found that a derivative of an active (gingerol) found in ginger i.e. zingerone, provides for such improved stability.
Patent CA-2813469-A1 (CA)
Title: Polymerizable chain-extended polysiloxanes with pendant hydrophilic groups
Inventor: CHANG FRANK
IPC: C08G77/48
Filed: 2011-10-05
Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polylsiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage -S-DR-S- in which DR is a divalent oranic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.
Patent CA-2815129-A1 (CA)
Title: Modular surgical instruments with contained electrical or mechanical systems
Inventor: ALLEN JAMES D IV
IPC: A61B18/12
Filed: 2013-05-06
Abstract: A surgical instrument includes an elongated shaft module and a handle module selectively separable from one another. The elongated shaft module includes an elongated shaft member and a pair of jaw members supported at a distal end of the elongated shaft member, at least one of the jaw members moveable relative to the other jaw member between open and closed positions. The handle module includes a housing including an opening extending longitudinally therethrough. The opening is dimensioned to permit passage of the pair of jaw members in the closed position. The handle module also includes a movable handle movable relative to the housing to move the pair of jaw members between open and closed positions, and a lock to secure the elongated shaft module in place within the housing.
Patent CA-2815848-A1 (CA)
Inventor: HUGHES JOHN
IPC: E21B23/06
Filed: 2013-05-13
Abstract: A wellbore packer for setting against a wellbore wall in a wellbore, the wellbore packer including: a mandrel including a upper end and an lower end; and an outer housing encircling the mandrel and including a first compression ring, a second compression ring, an annular packing element encircling the mandrel and positioned between the first compression ring and the second compression ring, the sealing element being expandable to form an annular seal about the packer by compression between the first compression ring and the second compression ring; and an anchoring mechanism including a slip that is expandable outwardly into a set position and a slip actuation assembly to drive expansion of the slip.
Patent CA-2815934-A1 (CA)
Title: Mass distribution device and molding device
Inventor: VAN GERWEN HENDRIKUS PETRUS GERARDUS
IPC: A23L13/00
Filed: 2011-10-24
Abstract: The present invention relates to an mass distribution device for supplying a mass of foodstuff starting material to one or more cavities of a mold drum for molding products from the mass, comprising a base member which extends partially around the outer cylindrical circumference of the drum and which has an introduction area through which the mass is the fed to the cavities. The invention further relates to a molding device and to a process for operating the inventive mass distribution device.
Patent CA-2817304-A1 (CA)
Inventor: PIKE JAMES ARTHUR
IPC: E21B17/02
Filed: 2013-05-29
Abstract: A downhole tool coupling (10) comprises first (11) and second (12) downhole tool elements that are securable one to the other in a releasably locking manner by moving the tool elements from a longitudinally relatively less proximate, especially overlapping position into longitudinally relatively more overlap with one another. The first downhole tool element (11) supports a first inductive, capacitative and/or magnetic energy coupler (23) and the second downhole tool element (12) supports a second inductive, capacitative and/or magnetic energy coupler (24). The first and second energy couplers (23, 24) are moveable from an energetically uncoupled position when the tool elements (11, 12) are in the longitudinally relatively less overlapping position to an energetically coupled position when the first and second downhole tool elements (11, 12) overlap relatively more.
Patent CA-2817739-A1 (CA)
Inventor: TETZLAFF STEVEN K
IPC: F04B35/04
Filed: 2011-11-08
Abstract: An electric motor of an electric submersible pump is electrically isolated from a power conduit for diagnostic testing of the power conduit and wet connection components in place within a wellbore. The electric motor is electrically connected to the power conduit through a wet connection assembly having motor leads in electrical connection with a transfer contact and a receptacle assembly disposed on a tubing string having a supply contact electrically connected to the power conduit. Electric power flows through the power conduit, through the supply contact, through the transfer contact, and through the motor leads to the motor. The supply contact and the transfer contact are separated by a sliding sleeve that hydraulically inserts between the contacts, insulating the transfer contact and grounding the supply contact for testing. The contacts may also be separated by a relative rotation of the assemblies that grounds the supply contact for testing.
Patent CA-2819346-A1 (CA)
Title: Pulse generator for cranial nerve stimulation
Inventor: COOK IAN A
IPC: A61N1/36
Filed: 2011-11-30
Abstract: Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.
Patent CA-2822070-A1 (CA)
Title: N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
Inventor: LI YUN-LONG
IPC: A61P35/00
Filed: 2011-12-19
Abstract: The present invention provides N-(1-(substituted-phenyl)ethyl)-9H-purin-6 amines derivatives: wherein Ar is a purine moiety, and RA and R1-R5 are as described herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. (see above formula)
Patent CA-2822691-A1 (CA)
Inventor: SCANLON CHRISTOPHER M
IPC: B05B11/00
Filed: 2012-01-12
Abstract: A hand -operable system for ejecting a fluid composition into an eye, the system comprises: a container (100) having a container opening (104) and containing the fluid composition; a double-acting pump mechanism (10) securely disposed over the container opening (104); and an actuator (80) that is disposed over, and extends radially outward from, said pump mechanism (10), for actuating the pump mechanism (10) by applying a force thereon, wherein said pump mechanism (10) comprises a passage (18, 19) for said fluid composition, and said passage (18, 19) is positively sealed off when the application of said force is discontinued.
Patent CA-2822697-A1 (CA)
Inventor: MAKOFSKY MARVIN A
IPC: B65D27/00
Filed: 2013-08-01
Abstract: The mailer is made from a single blank. In one embodiment, the side flaps are folded over a front panel followed by folding over and securing of a back panel to the said flaps to form the mailer. The closure panel is folded over the front panel to close the mailer. In another embodiment, a back panel is folded over a front panel followed by folding over and securing of the side flaps to the back panel to form the mailer. The closure flap is folded over the back panel to close the mailer. In another embodiment, a blank forms a center seam mailer. Each embodiment has an improved corner construction.