baber/WOPTO huggingface dataset:
Patent AU-2019216086-C1 (AU)
Title: PD-1 variant having improved binding to PD-L1
Inventor: JUNG SANG TAEK
IPC: C12N15/10
Filed: 2019-01-30
Granted: 2021-10-07
Abstract: The present invention relates to a PD-1 variant having improved binding to PD-L1. In addition, the present invention relates to a method for producing and a method for screening for the PD-1 variant. A PD-1 variant of the present invention effectively inhibits binding between wild-type PD-1 and PD-L1, and thus can be expected to have penetration power and an effect of cancer death by immunocytes or a treatment effect on infectious diseases, which are far greater than those of conventional therapeutic agents for immune checkpoint inhibition and, simultaneously, can minimize the possibility of immunogenicity occurrence and, further, can promote the convenience of developing biological pharmaceutical drugs through the implementation of aglycosylation.
Patent RU-2169486-C1 (RU)
Inventor: NAZARENKO S V
IPC: A23J1/14
Filed: 2000-07-19
Granted: 2001-06-27
Abstract: FIELD: food industry. SUBSTANCE: invention relates to production of protein foodstuffs from soybean. The parent raw is the oil cake in the form of partially defatted meal or groats (fat content is 5-12%) prepared in auger press from soybeans treated preliminary by dry extrusion method. Obtained soybean oil cake is treated with hydrochloric or other acid at pH 4.4-4.5 and hydromodulus = = (1:6)-(1:10) at temperature of extractive medium 40-60 C for 30-60 min. Then solid and liquid phases are separated and solid precipitate is washed with water at temperature 15-60 C. Washed concentrate is neutralized with alkaline or alkaline-earth metal, for example, sodium hydroxide to pH 6.8-7.2 followed by homogenization to homogeneous state and then dried in spraying dryer or other type dryer. Method provides regulation of residual content of lipids in ready product. EFFECT: improved method of preparing. 1 tbl, 2 ex
Patent RU-2165384-C1 (RU)
Inventor: KARTAVYJ A N
IPC: B65G15/16
Filed: 2000-07-27
Granted: 2001-04-20
Abstract: FIELD: mining industry; transportation of rock at open- cast and underground mining. SUBSTANCE: high-angle belt conveyor has carrying belt and pressure belt with drives, transfer sections and high-angle section on which pressure modules are mounted. Side and middle rollers in these modules are arranged separately, and pressing forces of rollers are preset by microprocessor depending on specific operating conditions of conveyor determined by material weight pickups, level of material on conveyor and belt speed pickups. Choice pf belt rigidly according to proposed equation is possible to provided operation of conveyor with increased service life and reduced power consumption at increased capacity. Bending of belts in space through 180 deg around conveyor axis at transfer sections provides possibility of turning conveyor high-angle section in plan depending on specific conditions of operation. EFFECT: enlarged operating capabilities. 5 cl, 8 dwg
Patent RU-2180583-C1 (RU)
Title: Therapeutic agent for treatment of different forms of heart rhythm disturbances
Inventor: JUNUSOV M S
IPC: A61P9/06
Filed: 2000-08-14
Granted: 2002-03-20
Abstract: FIELD: pharmacology and cardiology. SUBSTANCE: agent contains complex compound of diterpene alkaloid lampaconitin with glycyrrhizin acid at molar ratio 1: (2-8), preferably 1:4. Agent exhibits high arrhythmic activity in cases of different forms of heart rhythm disturbances, including fibrillation. Intensity of its antiarrythmic effect and low toxicity thereof make the agent better than majority of known antiarrythmics. EFFECT: reduced cost due reduced percentage of lampaconitin. 1 tbl, 5 ex
Patent RU-2176516-C1 (RU)
Title: Stress correcting adaptogen
Inventor: CHERNOV JU N
IPC: A61P43/00
Filed: 2000-11-17
Granted: 2001-12-10
Abstract: FIELD: medicine. SUBSTANCE: invention relates to novel stress correcting adaptogens. Invention proposes to use plant chufa, or earth almond, Cyperus esculentus L. as a tuber powder. Tuber powder of plant Cyperus esculentus L. used in daily dose 600 mg/kg before eating for 3 doses is an effective stress correcting adaptogen that enhances work ability of animals and human and exhibiting the protective effect under unfavorable conditions of emotional and physical factors of environment. EFFECT: enhanced effectiveness of adaptogen. 1 cl, 4 tbl, 4 ex
Patent RU-2185269-C1 (RU)
Title: Method for longitudinal intermittent grinding
Inventor: STEPANOV JU S
IPC: B24B7/00
Filed: 2001-02-13
Granted: 2002-07-20
Abstract: FIELD: deep peripheral grinding of hard-to-work materials having tendency to occurring of flaws such as burnouts and microcracking, particularly, grinding part at controlling heat flux directed into it. SUBSTANCE: method is realized at relative motion of blank and buildup grinding disc. The last is in the form of even number of abrasive discs mounted on common mandrel with axial gap one relative to another. Each disc is in the form of truncated circular cylinder whose one end is inclined by acute angle α to plane normal relative to its rotation axis. Discs are mounted in pairs in such a way that their unbalanced portions are arranged diametrically opposite and in antiphase; their tapered ends are turned one to another and they are mutually parallel. Gap between discs may be regulated by means of spacing washers. In description of invention formula is given for calculating angle α in depending upon outer diameter, minimum height of abrasive disc and axial gap between discs. EFFECT: enhanced efficiency of grinding due to optimized thermal stress of process, improved quality of ground parts due to oscillation of mean portion of cutting zone. 7 dwg
Patent RU-2190943-C1 (RU)
Title: Decoration for woman's dress cut integral with bodice part
Inventor: GRUZDEVA A A
IPC: A41D27/08
Filed: 2001-06-22
Granted: 2002-10-20
Abstract: FIELD: sewing industry. SUBSTANCE: decoration is made from rectangular fabric panel and formed by preliminary double folding of panel for obtaining two horizontal boundary lines on bodice part. Lower boundary line is positioned above line of arrangement of highest chest points and is formed by folding bodice part in horizontal plane with face side being turned inward. Upper boundary line has discontinuity in the middle portion, which may be eliminated by binding cord passed along edge of bodice side, with bodice side being preliminarily creased into circle. Such construction allows three-dimensional movable decoration to be obtained without using pattern and to be formed without special skills. EFFECT: simplified construction and reduced labor intensity. 5 dwg
Patent RU-2194181-C1 (RU)
Title: Gas turbine engine fuel feed and control system
Inventor: GORBUNOV L TS
IPC: F02C9/26
Filed: 2001-06-25
Granted: 2002-12-10
Abstract: FIELD: aircraft industry. SUBSTANCE: invention relates to aircraft fuel feed control systems. Said system has electrically driven pumping unit controlled in response to speed of rotation, and electronic control unit. Pumping unit has pump and volumetric metering device series connected to fuel system. Metering device is furnished with constant pressure differential maintaining element. Said components of pumping unit have common shaft driven by electric motor. At delivery of fuel from to volumetric metering device and further on to outlet and engine nozzles, owing to maintaining constant pressure differential across metering device, internal overflows in said device is preserved irrespective of pressure in nozzles. EFFECT: increased accuracy of metering, enlarged sphere of application. 5 cl, 2 dwg
Patent RU-2193336-C1 (RU)
Title: Sitting and lying furniture
Inventor: KRAVCHENKO M V
IPC: A47C17/13
Filed: 2001-07-17
Granted: 2002-11-27
Abstract: FIELD: production of furniture. SUBSTANCE: furniture has casing 1 with back 2 and seat 3, extendable part with carcass 4 and cushion 5, guides 11 mounted on casing sides 10, to which carcass is attached. Transformation mechanism 6 is fixed on rigid base of cushion and on side sheet steel cylinders 7 of carcass 4. Supporting-guiding members 13 are attached to side sheet steel cylinders 7 and put on guides 11. When furniture is used for sitting, cushion 5 is positioned inside carcass 4 of extensible part, which is positioned under seat 3 so that extensible part and its members are held by guides 11 and supporting-guiding members 13 at predetermined distance from floor, when furniture is used for lying, cushion 5 is urged by transformation mechanism 6 to move under seat 3 and to be hinged up by at least one supporting lever of transformation mechanism 6 and held by means of supporting member 22 at such distance from floor that cushion surface forms together with seat surface single horizontal surface for lying. Each side sheet steel cylinder 7 and related supporting-guiding member 13 are arranged in single plane one under another. Bracket 23 is fixed at an angle to supporting member 22 of supporting lever so that it normally rests upon floor, and carcass 4 of extensible part is normally in horizontal position, when furniture is transformed from sitting position to lying position and vice versa. EFFECT: light weight and simplified construction, enhanced reliability in operation and increased convenience. 4 cl, 8 dwg, 1 ex
Patent RU-2200578-C1 (RU)
Title: Method for increasing total unspecific body resistance in neonatal calves
Inventor: SISJAGIN P N
IPC: A61K35/20
Filed: 2001-07-16
Granted: 2003-03-20
Abstract: FIELD: veterinary science. SUBSTANCE: from the first day of life calves are fed with ozonized colostrum at ozone concentration being 1.2-1.3 mg/l for 7 d at 24-h-long interval in addition to introduction of UNSPECIFIC immunoglobulin. The suggested method provides 100% efficiency due to stimulation of UNSPECIFIC resistance factors. EFFECT: higher efficiency. 2 ex, 2 tbl
Patent RU-2211328-C1 (RU)
Inventor: GRIGASHKIN G A
IPC: E21B47/00
Filed: 2002-01-17
Granted: 2003-08-27
Abstract: FIELD: equipment providing for well drilling; applicable in power supply of downhole devices. SUBSTANCE: power source has body installed in interval between string drill pipes. Secured to body are thermoelements interconnected with one another and with downhole devices by wires. Thermoelements are installed in recesses made over circumference on body external surface. Recesses may be arranged in several rows. Thermoelements may be filled in recesses with composite material or rubber mixture. Electric wires may be introduced inside body and insulated. Each thermoelement consists of series circuit of different conductors forming points of electric contacts. Thermoelements may be connected in parallel, or series, or series-parallel. EFFECT: increased power and reliability of power source. 6 cl, 2 dwg
Patent RU-2208661-C1 (RU)
Title: Mixture for electric contact baking-on
Inventor: CHIZHOV V N
IPC: C23C24/08
Filed: 2002-01-28
Granted: 2003-07-20
Abstract: FIELD: powder metallurgy; applicable in deposition by baking-on of resistant to wear, antifriction coatings to surface of new and worn parts. SUBSTANCE: mixture contains iron powder and calcium fluoride and additional carbamide-formaldehyde resin, with the following amounts of mixture components, wt.%: calcium fluoride 8-14; carbamide-formaldehyde resin 12.1-15; the balance, iron powder. EFFECT: higher quality of coating, particularly, its wear resistance, reduced cost of mixture. 3 ex
Patent RU-2218486-C1 (RU)
Title: Electrohydraulic servo drive
Inventor: PONOMARENKO ANATOLIJ ALEKSANDR
IPC: F15B9/00
Filed: 2002-03-07
Granted: 2003-12-10
Abstract: FIELD: aircraft industry. SUBSTANCE: proposed drive is designed for aircraft control system. Cradle accommodating axial-plunger or axial-piston pump is hinge-connected at one side with cylindrical plunger of servomechanism through axial longitudinal rectangular slot made in middle of plunger, and at other side it is pressed through pusher by spring through maximum capacity angle. Control space of servomechanism communicates with two control ports of hydraulic distributor through central groove of power limiter made in form of spring-loaded double-land spool with possibility of disconnection of its central groove from control channel of hydraulic distributor and communicating it through edge of safety valve with drain. Moreover, speed regulator is installed additional in pump suction channel made in form of double-land spring-loaded spool whose left-hand end face space communicates with delivery channel, and spring-loaded space communicates with two control ports of hydraulic distributor. Drain channels of hydraulic distributor communicates with central groove of spool which, in its turn, communicates with suction channel of pump through variable restrictor. EFFECT: reduced mass and overall dimensions of pump cradle, enlarged bandwidth of low-frequency control signals, simplified mechanical coupling with cradle, increased efficiency of pump. 2 cl, 1 dwg
Patent RU-2212612-C1 (RU)
Title: Weapon firing mechanism
Inventor: STERKHOV V A
IPC: F41A19/59
Filed: 2002-03-13
Granted: 2003-09-20
Abstract: FIELD: weapon with an electromechanical firing mechanism, in particular, pneumatic weapon. SUBSTANCE: the firing mechanism has a barrel, trigger, bullet extracting device, pulse generator and an electromagnetic drive. The armature of the electromagnetic drive is made in the form of a hammer. The electromagnetic drive is made for engagement of the hammer with the bullet extracting device under the action of an electric signal fed to it from the pulse generator. The electromagnetic drive is made for engagement of the hammer with the bullet extracting device during a preset time. EFFECT: enhanced reliability, close grouping and accuracy of fire. 2 cl, 2 dwg
Patent RU-2228226-C1 (RU)
Inventor: SLADKOVA L A
IPC: B07B1/42
Filed: 2002-10-29
Granted: 2004-05-10
Abstract: FIELD: food-processing, mining and building machines. SUBSTANCE: proposed screen includes sieve mounted for performing oscillatory motion, mechanism for setting sieve in oscillatory motion; this mechanism includes drive with polyhedral unit mounted on its shaft; polyhedral unit is made from separate components mounted in their guides for fixed motion over them. Guides are mounted on shaft for change of angle between adjacent guides. EFFECT: enhanced efficiency of screening. 2 dwg
Patent RU-2214964-C1 (RU)
Inventor: MUKHIN V M
IPC: C01B31/08
Filed: 2002-11-04
Granted: 2003-10-27
Abstract: FIELD: sorption technique, environment safety. SUBSTANCE: method for reactivation of depleted activated carbon in different adsorption processes involves dry of wetted carbon at temperature 450-560 C at rate its rise 25-40 C/min, the following thermal treatment at temperature 620-720 C with heating rate 8-12 C/min, cooling carbon in medium of overheated steam to temperature 120-200 C. method provides complete recovery of parent properties of adsorbents depleted in different liquid media, among them, in extraction of gold from solutions and pulps. Invention can be used for reactivation (regeneration) of granulated carbons depleted in treatment of different liquid media and in process of gold sorption from solutions and pulp in gold-extracting plants. EFFECT: improved reactivation method. 3 ex
Patent RU-2232685-C1 (RU)
Title: Traction and-transport vehicle
Inventor: BATORSHIN V P
IPC: B60K17/10
Filed: 2002-11-25
Granted: 2004-07-20
Abstract: FIELD: agriculture, road machinery. 
     SUBSTANCE: invention can be used in wheeled self-propelled machines and tractors operating in assembly with semi-mounted machines, semi-trailers and trailers. Proposed traction-and-transport vehicle has frame, driven and ands driving axles with steerable front and driving rear wheels, engine, hydrostatic transmission, makeup pump, hydrostatic steering gear, shoe brakes on driving wheels equipped with wheel brake cylinders, and hydraulically operated mounting with hitch in form of fork with pivot. Wheel brakes are made with separate control circuits, each consisting of master cylinder communicating with wheel brake cylinder, servocylinder whose piston space communicates with output of control valve, one of inputs of control valve and rod space of servocylinder being communicated with pressure main line of makeup pump, and second input being placed in communication with hydraulic tank. Control valve spool is mechanically coupled with brake pedal, and rod of servocylinder, with piston of master cylinder. Hitch is furnished with pivot lifting and lowering hydraulic cylinder. Power hydraulic cylinders of mounting is controlled by hydraulic unit including safety valve and three-position four-line distributor. Pivot lifting and lowering hydraulic cylinder is hydraulically coupled with two-position four-line electrically-controlled distributor. 
     EFFECT: improved maneuverability and cross-country capacity of vehicle, reliability of running and increased utilization factor of delivery of pump of mounting and steering gear hydraulic system. 
     2 cl, 2 dwg
Patent RU-2227911-C1 (RU)
Inventor: MARKOV A A
IPC: G01N29/40
Filed: 2002-12-19
Granted: 2004-04-27
Abstract: Изобретение относится к неразрушающему контролю материалов и изделий и может быть использовано при ультразвуковой (УЗ) дефектоскопии железнодорожных рельсов и других длинномерных изделий. Отличие предложенного способа от известных заключается в выборе временного окна приема УЗ преобразователей большим, чем время распространения ультразвукового сигнала от точки излучения до границы рельса, оценке и запоминании максимальных амплитуд эхо-сигналов, принятии момента достижения этих значений моментом приема эхо-сигнала, отображении результатов прозвучивания участка рельса всеми УЗ преобразователями в виде развертки типа В с учетом максимальных амплитуд эхо-сигналов и получивших их ультразвуковых преобразователей, использовании временной зависимости максимальных амплитуд эхо-сигналов по выбранному участку рельса и ультразвуковому преобразователю для детальной идентификации неоднородностей в рельсе. Предложенный способ позволяет повысить качество и точность дефектоскопии за счет возможности обнаружения отраженными УЗ сигналами дефектов, "невидимых" при прямом прозвучивании, более точного определения координат дефектов, более удобного интерфейса с оператором и возможности детальной идентификации неоднородностей в рельсе. 8 ил.
Patent RU-2231579-C1 (RU)
Inventor: TIMOFEEV N I
IPC: C25D9/12
Filed: 2003-01-05
Granted: 2004-06-27
Abstract: FIELD: methods of electro-chemical deposition of protective covers on surfaces of items made out of silver and its alloys. 
     SUBSTANCE: the invention presents a method of electro-chemical deposition of protective covers on surfaces of items made out of silver and its alloys with copper, that may be used for production of medals, cutleries, wares, jewels, etc. for their protection against tarnish. The method provides for a cathodic treatment of items previously degreased in an electrolyte containing, g/l: potassium chromate - 80-120 and sodium carbonate - 60-80 at the cathodic current density of 0.4-0.8 А/decimeter within 2-10 minutes at the temperature of 5-60°С with the anode made out of graphitized carbon material, the subsequent washing and a drying. The technical result: spreading of the method functionalities at the expense of application of protective covers, that are visually not observable on items made out of silver and its alloys with copper, an intensification and simplification of the method. Besides, the method is effective even in the cases, when treated items already have stains. 
     EFFECT: the invention allows to apply the protective covers, that are visually not observable even on items with stains. 
     2 cl, 3 ex
Patent RU-2231772-C1 (RU)
Title: Method for determining adhesion strength of composite materials
Inventor: KOLMOGOROV G L
IPC: G01N19/04
Filed: 2003-02-03
Granted: 2004-06-27
Abstract: FIELD: mechanical testing of composite materials. 
     SUBSTANCE: method comprises steps of upsetting cylindrical sample between flat mutually parallel plates; using sample having concentric protruded shoulders on end surfaces; measuring effort of press at upsetting; fixing effort of press at time moment of tearing outer annular layer in the form of cylindrical envelope from central part of sample; calculating adhesion strength according to value of measured effort referred to tearing off surface area of outer annular layer from central part of sample. 
     EFFECT: possibility for determining adhesion strength of composite materials with formed fibrous structure. 
     1 dwg
Patent RU-2236363-C1 (RU)
Title: Diesel locomotive bogie support-and-return device
Inventor: SLIVINSKIJ E V
IPC: B61K3/00
Filed: 2003-03-31
Granted: 2004-09-20
Abstract: FIELD: transport engineering; rail vehicles. 
     SUBSTANCE: proposed device consists of socket, movable support plate rigidly connected to body secured on bogie frame and filled with axle lubricant. Cylinder with piston installed in cylinder for movement is arranged on body. Piston rod is connected to movable support plate. Inner space of body is connected with underpiston and overpiston spaces of cylinder through pipes. Said cylinder spaces are furnished with additional pipelines whose ends adjoin flanges of wheels of bogie wheelset through air gap. All indicated pipelines are furnished with single-acting valves to pass axle lubricant. 
     EFFECT: enlarged operating capabilities of locomotive. 
     4 dwg
Patent RU-2234428-C1 (RU)
Inventor: LOBOZOV V P
IPC: B60K17/22
Filed: 2003-04-24
Granted: 2004-08-20
Abstract: FIELD: transport engineering. 
     SUBSTANCE: proposed propeller shaft has two flange-fork, each with lugs and holes and flange with end face splines, movable joint consisting of sliding fork with lugs and holes, shank with outer splines and splined shaft consisting of interconnected bushing with inner splines, tube and welded-to fork with lugs and holes, and also two joints, each consisting of cross and needle bearings. Thermally treated steel of reduced hardness penetration subjected to preliminary thermal treatment, coming to use of forging heat, and final thermal treatment in form of three-axial surface hardening with self- tempering or furnace tempering, is used for manufacture of flange-fork, sliding fork and welded-to fork of splined shaft. 
     EFFECT: increased service life of propeller shaft, reduced mass and cost of manufacture of shaft. 
     3 dwg
Patent RU-2246103-C1 (RU)
Inventor: NOSYREV D JA
IPC: G01M15/00
Filed: 2003-07-01
Granted: 2005-02-10
Abstract: Изобретение относится к двигателестроению, в частности к измерительной технике, и может быть использовано для определения технического состояния двигателей внутреннего сгорания (ДВС). Изобретение позволяет повысить точность и достоверность определения технического состояния ДВС в эксплуатационных условиях путем косвенного индицирования цилиндров за счет использования более сложной модели, позволяющей точно идентифицировать экспериментальные данные, а также за счет использования в качестве исходного материала для процесса контроля и диагностирования индикаторную диаграмму давлений. Способ диагностики двигателя внутреннего сгорания путем непрерывного нахождения индикаторной диаграммы цилиндра в зависимости от угла поворота вала или по времени путем измерения напряжений, действующих в шпильках или болтах, крепящих головку блока цилиндров, при котором сравнивают эту диаграмму и ее числовые показатели с эталонными. Индикаторную диаграмму цилиндра получают с помощью предварительно построенной тарировочной зависимости, построенной одновременно по текущим значениям измеренных напряжений и давлений в цилиндре, не менее чем при трех значениях угла поворота коленчатого вала, и по полученной индикаторной диаграмме давлений вычисляют числовые показатели, сравнивают их с эталонными и определяют техническое состояние двигателя. 3 з.п. ф-лы, 3 ил.