baber/WOPTO huggingface dataset:
Patent MA-43461-A1 (MA)
Title: Nouveaux peptides, combinaisons de peptides et supports pour utilisation dans le traitementimmunothérapeutique de divers cancers
Inventor: WEINSCHENK TONI
IPC: C07K14/47
Filed: 2016-08-26
Abstract: La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules pour utilisation dans des procédés immunothérapeutiques. La présente invention concerne, en particulier, l'immunothérapie du cancer. La présente invention concerne, en outre, des épitopes peptidiques des lymphocytes t associés à une tumeur, seuls ou en combinaison avec d'autres peptides associés à une tumeur, qui peuvent, par exemple, servir de principes pharmaceutiques actifs pour des compositions vaccinales qui stimulent les réponses immunitaires antitumorales, ou pour stimuler des lymphocytes t ex vivo et les transférer aux patients. Des peptides liés aux molécules du complexe majeur d'histocompatibilité (cmh), ou des peptides en tant que tels, peuvent également être des cibles d'anticorps, de récepteurs des lymphocytes t solubles et d'autres molécules de liaison.
Patent MA-45888-A1 (MA)
Title: Inhibiteurs de tyrosine kinase de bruton
Inventor: IAKOVLEV PAVEL ANDREEVICH
IPC: C07D471/04
Filed: 2017-11-16
Abstract: La présente invention concerne un nouveau composé représenté par la formule i, ou un sel, un solvate ou un stéréoisomère pharmaceutiquement acceptable de celui-ci, dans laquelle : v1 est c ou n, v2 est c(r2) ou n, ainsi si v1 est c alors v2 est n, si v1 est c alors v2 est c(r2), ou si v1 est n alors v2 est c(r2); chaque n, k est indépendamment 0, 1; chaque r2, r11 est indépendamment h, d, hal, cn, nr'r", c(o)nr'r", un alkoxy c1-c6; r3 est h, d, un hydroxy, un alkyle en c(o)c1-c6, un alcényle en c(o)c2-c6 , un alcényle en c(o)c2-c6, un alkyle en c1-c6; r4 est h, hal, cn, conr'r", un hydroxy, un alkyle en c1-c6, un alkoxy c1-c6; l est ch2, nh, o ou une liaison chimique; r1 est choisi dans le groupe de fragments, comprenant : fragment 1, fragment 2, fragment 3 chaque a1, a2, a3, a4 est indépendamment ch, n, chal; chaque a5, a6, a7, a8, a9 est indépendamment c, ch ou n; r5 est h, cn, hal, conr'r", un alkyle en c1-c6, non substitué ou substitué par un ou plusieurs halogènes; chaque r' et r" est indépendamment sélectionné dans le groupe comprenant, h, un alkyle en c1-c6, un cycloalkyle en c1-c6, un aryle; r6 est sélectionné dans le groupe : [formule ii] chaque r7, r8, r9, r10est indépendamment un vinyle, un méthylacétylényle; hal est ci, br, i, f, qui possèdent des propriétés d'un inhibiteur de tyrosine kinase de bruton (btk), la présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, et leur utilisation en tant qu'agents pharmaceutiques dans le traitement de maladies et troubles.
Patent UY-23585-A1 (UY)
Title: Rueda giratoria para desplazamientos longitudinales y transversales
Inventor: BONZINI NÉSTOR JOSÉ
IPC: B62B3/00
Filed: 1993-05-24
Abstract: Rueda giratoria para desplazamientos longitudinales y transversales, del tipo que comprende un cuerpo circular capacitado para montarse sobre un eje de giro y provisto de una banda de rodamientos y de apoyo sobre el piso, caracterizada por estar, dicha banda de rodamiento, constituida por, al menos, dos pluralidades de rodillos montados a libre giro respecto de dicho cuerpo y con sus respectivos ejes independientes tangentes a sendas circunferencias iguales, paralelas entre si y estando los rodillos de cada pluralidad alternados angularmente con los de las pluralidades adyacentes, siendo la longitud de cada rodillo mayor que la separación entre cada dos sucesivos de ellos.
Patent UY-24366-A1 (UY)
Title: Maquina para sacar tallos de hojas de tabaco
IPC: A24B5/06
Filed: 1996-11-15
Abstract: La máquina se encuentra ubicada preferentemente en la cinta de picking, y está compuesta entre otros por: un conjunto de discos giratorios sacadores de tallos, dispuestos en un mismo eje geométrico, provistos de velocidades distintas, que giran en la misma dirección unos respecto a otros y respecto a la cinta transportadora del picking; los discos están dispuestos paralelos, guardando distancias regulares entre sí y tienen bordes dentados; un conjunto de herramientas estelares giratorias sacadoras de los residuos de lámina de los tallos, dispuestas adelante, arriba e intercaladas a los discos sacadores de tallos; y un aparador ubicado a lo largo de los discos, entre el punto de recepción de las hojas de tabaco y las herramientas estelares sacadoras de residuos.
Patent UY-30823-A1 (UY)
Title: Piperidinas sustituidas que contienen una fraccion de heteroarilamida o heteroarilfenilo
Inventor: CARR GREGORY RICHARD
IPC: A61K31/52
Filed: 2007-12-20
Abstract: PIPERIDINAS SUSTITUIDAS QUE CONTIENEN UNA FRACCION DE HETEROARILAMIDA O HETEROARILFENILO La invencion proporciona compuestos de formula (I) que tienen compuestos inhibidores de la quinasa PKA y PKB de formula (I) : O sales, solvatos, tautomeros o N-oxidos de los mismos, donde (1) GP es un grupo GP1 (2) GP es un grupo GP 2 Donde HET es un grupo heterocíclico monocíclico o bicíclico que contiene hasta 4 miembros del anillo de heteroátomo; el anillo V es un grupo heteroarilo monociclito o bicíclico de a 5 a 10 miembros en el anillo ; y R7, R10, Q2a, Ga, x, w, y f son como se define en las reivindicaciones
Patent DZ-1821-A1 (DZ)
Inventor: FOURATI MAHER
IPC: A61M1/08
Filed: 1994-10-24
Granted: 2002-02-17
Abstract: A surgical instrument for treating a hydatid cyst, including a cannula (100) provided with a suction cup (200) at its distal end (118, 218) and connected to a vacuum source at its proximal end (119), and at least one hollow aspirating needle (300, 400) with its distal end (302, 402) surrounded by the cannula (100), said needle being translatable relative to the cannula (100) between a first position in which the tip (302, 402) of the needle (300, 400) is retracted into the suction cup (200) or the cannula, and a second, aspirating position in which the tip (302, 402) of the needle projects beyond the suction cup (200).
Patent ES-177210-A1 (ES)
Title: MEJORAS EN O RELATIVAS A CIRCUITOS DISCRIMINADORES, PARTICULARMENTE PARA SISTEMAS DE SINCRONIZACION EN TELEVISIoN
Filed: 1947-03-13
Abstract: Mejoras en circuitos discriminadores para separar las señales de sincronización de línea y cuadro en un receptor de televisión caracterizado porque comprenden una válvula termoiónica, un circuito de entrada conectado entre un electrodo de control de dicha válvula y tierra y circuitos de salida que presentan impedancias adecuadas respectivamente a las dos ondas de señal de sincronización diferentes, estando dichos circuitos de salida conectados respectivamente entre el ánodo de salida de la válvula y tierra.
Patent ES-181161-A1 (ES)
Title: UN DISPOSITIVO PARA LA RECEPCIoN DE IMPULSOS CUYOS INTERVALOS CARACTERIZAN UNA SENAL A TRANSMITIR
Filed: 1947-12-26
Abstract: Dispositivo para la recepción de impulsos de duración constante cuyos intervalos caracterizan una señal a transmitir, en el cual la sensibilidad del receptor se reduce cada vez entre dos impulsos consecutivos; caracterizado por el hecho de que tiene medios para modificar la duración de la limitación de la sensibilidad en función de la señal transmitida; pudiendo presentar además este dispositivo las particularidades siguientes, tomadas por separado o en combinación: a) Tiene un generador de impulsos de bloqueo cuya duración se puede modificar con ayuda de una tensión de regulación tomada del desmodulador de los impulsos recibidos. b) La tensión de regulación del generador de impulsos de bloqueo se aplica a este último por mediación de un filtro pasa-bajo. c) La frecuencia de corte del filtro pasa-bajo es inferior al valor medio de la frecuencia de los impulsos de repetición. d) La frecuencia de corte del filtro pasa-bajo es inferior a la frecuencia máxima de la señal transmitida. e) Elgenerador de impulsos de bloqueo está constituido por un tubo de descarga de rejillas múltiples, con preferencia una pentodo, que tiene un acoplamiento capacitivo entre la rejilla-pantalla y la rejilla de frenado y la tensión de regulación variable con la señal transmitida se aplica a la rejilla de control. f) La tensión de regulación, variable con la señal transmitida, se obtiene aplicando los impulsos de señal, cuyos intervalos variables caracterizan la señal transmitida, a un discriminador de fase o de frecuencia. g) Los impulsos de señal se aplican al discriminador de fase o de frecuencia por mediación de un filtro selectivo, que convierte los citados impulsos en oscilaciones sinuosidales moduladas en fase o en frecuencia.
Patent ES-181226-A1 (ES)
Title: PERFECCIONAMIENTOS EN LAS LANZAS DE LiQUIDO PARA CHORRO INTERMITENTE
Filed: 1947-12-29
Abstract: Perfeccionamientos en lanzas de líquidos para chorro intermitente, caracterizándose porque entre la llegada de líquido y la tobera de lanzamiento hay dispuesta una cámara cilíndrica en la que va encerrado un rotor libre cilíndrico, de sección inferior y dispuesto de modo que su eje sea paralelo al eje de esta cámara, yendo dirigido el orificio de entrada de líquido en esta última, en sentido oblícuo con relación a su pared y en sentido inverso a la dirección de salida por la tobera antedicha, de modo que el expresado rotor rueda sobre esta pared cilíndrica de la cámara cerrando alternativamente el orificio de entrada y el orificio de salida.
Patent ES-182140-A1 (ES)
Title: Un dispositivo para el estirado de fibras
Filed: 1948-02-06
Abstract: Un dispositivo para el estirado de fibras, que comprende una cubierta de rodillo cuya superficie de trabajo, al menos, comprende alcohol polivinílico modificado.
Patent ES-188101-A1 (ES)
Title: DISPOSITIVO TERMOMECáNICO PARA LA FABRICACIoN DE ABALORIOS DE VIDRIO
Filed: 1949-05-06
Abstract: Dispositivo termomecánico para la fabricación de abalorios de vidrio caracterizado porque la gota de vidrio procedente de una varilla de grueso y color adecuados se obtiene por fusión por medio de un soplete de características que luego se dirán u se deposita sobre un tubo soporte casi capilar dotado de movimiento giratorio esta tensado por medio de un resorte y se mantiene caliente por medio de gas combustible que sale por pequeños y próximos orificios practicados en otro tubo situado verticalmente debajo del anterior.
Patent ES-268758-A1 (ES)
Title: Process for the production of gases from hydrocarbon oil and removal of carbon particles therefrom
IPC: C09C1/48
Filed: 1961-07-03
Abstract: A process for removing soot from suspensions thereof in water p comprises mixing the suspension with a water-immiscible auxiliary liquid e.g. oil, separating the soot and oil from the water by filtering as through a perforated endless belt, and filtering the still impure aqueous phase either through three layers respectively of progressively larger or smaller particles of granular silica e.g. sand or gravel, the finest layer of which may be continuously or intermittently renewed, or through a homogeneous mixture of such particles of different sizes. The silica may be kept covered with a layer of the aqueous phase, from which floating impurities are skimmed. Quantitative process examples are given.
Patent ES-271795-A1 (ES)
Title: New fused polycyclic hydrocarbon derivatives and processes for their production
IPC: C07J75/00
Filed: 1961-11-06
Abstract: The invention comprises A-nor-B-homo-10#x-estrane compounds having the formula: <FORM:0965714/C1/1> (wherein R1 is hydrogen or an acyl radical derived from a lower organic acid, and R2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, as well as the enol esters derived from carboxylic acids of the compounds of the specified general formula in which R2 is hydrogen and processes for the preparation thereof by subjecting a 17b -acyloxy-A-nor-B-homo-estr-5(10)-ene-3 6-dione having the formula: <FORM:0965714/C1/2> (wherein R is an acyl radical derived from a lower organic acid) to reduction by an alkali metal borohydride in an acidic medium so as to selectively saturate the 5(10)-double bond thus yielding the corresponding 17b -acyloxy-A-nor-B-homo-5#x, 10#x-estrane-3, 6-dione, if desired saponifying this compound to obtain the corresponding 17b -hydroxy compound, or alternatively if desired treating with an alkylating agent in the presence of a basic condensation catalyst so as to form the corresponding 17b -hydroxy or 17b -acyloxy-5#x-lower alkyl-A-nor-B-homo-10#x-estrane -3, 6-dione. Reduction may be effected with alkali metal borohydride, e.g. potassium borohydride, and the alkylation may be effected with an alkyl iodide. Specification 965,712 is referred to.
Patent ES-299207-A1 (ES)
Title: Processes for preparing 2-alkyl-cyclopentane derivatives, and the derivatives thus prpared
IPC: C07C45/67
Filed: 1964-04-27
Abstract: The invention comprises compounds of the formula <FORM:1057116/C2/1> (wherein R is alkyl and R5 is hydrogen or alkyl) and their enolic forms, and their preparation by reacting compounds of the formula <FORM:1057116/C2/2> (wherein R3 and R4 are alkyl) with an alkali metal alcoholate in an aprotic solvent to form the required 4-alkoxycarbonyl compounds and, if desired, hydrolysing these to the free acids. This process may be combined with the further step of decarboxylating the free acids to form 1,3-dioxo-2-alkyl-cyclopentanes, with or without isolation of the carboxylates.
Patent ES-312769-A1 (ES)
Title: Improvements in and relating to methods of manufacturing semiconductor bodies
IPC: H01L27/07
Filed: 1965-05-10
Abstract: A method of manufacturing a semi-conductor body comprises forming a cavity in an initial semi-conductor body, at least the final step in forming the cavity being a chemical etching step, and epitaxially depositing semi-conductor material in the cavity to form a junction. The junction may be of the PN, PP+, or NN+ type and/or may be a heterojunction. As shown, Fig. 2, a wafer 1 of P-type silicon has a shallow cavity 3 and a deeper main cavity 2 etched in one face in two separate etching steps using masks formed by etching windows in oxide layers using a photo-resist technique. Shallower cavity 3 has a depth equal to the maximum desired tolerance for cavity 2. The depths of the cavities are measured, the remaining oxide layer is removed and the wafer is prepared by degreasing, boiling in nitric acid, removing the resultant oxide coating in hydrogen fluoride vapour and briefly etching in a mixture of hydrofluoric and nitric acids. The wafer is placed in a furnace in an atmosphere of hydrogen into which is introduced silicon tetrachloride and phosphorus trichloride to grow an N-type epitaxial layer 5 on body 1 to a depth slightly greater than that of cavity 2. The epitaxial layer is polished to line 7 this being determined by using a staining etchant which produces visible differentiation between P and N-type materials. As shown, Fig. 4, a diode is produced from the resultant wafer by growing a layer of oxide on the surface, removing this layer on the lower face of the wafer and forming a window over cavity 2 filled with epitaxial material. The wafer is alloyed to a strip or header 10 made of " Kovar" (Registered Trade Mark) coated with, or with the interposition of a foil of, gold which may contain boron. Gold-antimony alloy 13 is applied through the window and is alloyed to the epitaxial layer. An aluminium contact 14 is evaporated on to the surface of the wafer and may be thickened by electrodepositing material on to it. Alternatively a wire can be connected to alloy 13 by thermo-compression bonding. A transistor, Fig. 5 (not shown), may be manufactured from an N-type wafer in which a shallow cavity is filled with P-type epitaxial material doped with boron, polished to the required level determined by measuring the sheet resistivity of the epitaxial material in the cavity or in a monitoring cavity with a larger area, and producing an emitter region by diffusion, alloying or epitaxial deposition. Ohmic contacts can be made to P- and N-type materials simultaneously by diffusing phosphorus into the surface of the N-type region, evaporating aluminium on to the surface and alloying. The compositions of suitable etchants for the various operations are described. The invention may be used to produce other circuit elements such as resistors and capacitors in integrated circuits.
Patent ES-340793-A1 (ES)
Title: Container closure seaming method and apparatus
IPC: B21D51/32
Filed: 1967-05-20
Abstract: A method of seaming an end closure 2, Fig. 1, having a curled rim to the flanged end of a can 1 comprises pinching the rim round the flange, Fig. 2, by pressing the rim against the projecting part of a mandrel 3, turning the pinched rim obliquely, Fig. 3 (not shown), and finally pressing it against the side wall of the can, Fig. 4 (not shown). The various stages are performed by rollers, and the seaming head or the can may be rotated, the roller 4 being pressed towards the mandrel-rim by a spring 6. A seaming head, Fig. 5 (not shown), may include two rollers (m 1 ) for performing the operation of Fig. 2, and a further two (m 2 , m 3 ) for performing respectively the operations of turning the pinched rim (Fig. 3) and pressing it against the side-wall (Fig. 4). Due to overlap, the seaming operation may be completed in 4 rotations of the seaming head, or in 5 revolutions if a three-roller head is used, Fig. 6 (not shown), or in 51/ 6 revolutions if the rollers are close together and the can is rotated, Fig. 7 (not shown).
Patent ES-350220-A1 (ES)
Title: Xerographic plate and process
IPC: G03G5/05
Filed: 1968-02-06
Abstract: A photoconductive member for use in electrophotography or a vidicon system comprises a layer comprising vitreous selenium and overlying the layer a photoconductive layer containing an insulating resin binder. The member may be self-supporting or on a substrate of Al, brass, steel, Cu, Ni or Zn, a plastics or glass sheet coated with Al, SnO or In 2 O 3 , or conductive paper. The vitreous selenium layer may be evaporated on to the substrate and comprises CdSe, Cd 2 SSe, TeSe, As 2 Se 3 , or alloys of Se with Te, S or As and I. The photoconductive layer comprising the binder is exemplified by polyvinylcarbazole and 2, 4, 7-trinitrofluorenone, phthalocyanine and silicone resin, polyamide, polyurethane, cellulose acetate, or a mixture of epoxy, phenolic and ureaformaldehyde resins, oxadiazole, phenoxy resin and brilliant green, or triphenylamine, phenoxy resin and 2,4,7- trinitrofluorenone. May other materials for the photoconductive layer are specified.
Patent ES-359709-A1 (ES)
Title: Penicillin intermediate
IPC: B65D85/00
Filed: 1968-10-29
Abstract: 6-Aminopenicillanic acid or a salt thereof is prepared by treating a natural penicillin with a penicillin amidase in the presence of an active hydrazide. The natural penicillin may have the formula wherein R is C 1-10 alkyl, C 3-10 alkenyl, or R1XCH 2 in which 'X is S or O, R1 is C 2-6 alkyl, C 3-6 alkenyl, phenyl or a monosubstituted phenyl group in which the substituent is Cl, Br, I, F, nitro, C 1-6 alkyl, C 3-6 alkenyl or C 1-6 alkoxy and the active hydrazide is preferably carbo-, phenylacetic, naphthylacetic., 3-indolecarboxylic acid-, 2-thiophenecarboxylic acid-, succinic acid-, glycine-, tyrosine-, butyric acid- or cyclopentane carboxylic acid-hydrazide or a hydrazide of the formula wherein R1, R2 and R3 are each the same or different and are H, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, amino, N(C 1-6 ) alkylamino or N,N- di-(C 1-6 ) alkylamino. The penicillin amidane may be produced from Botrytis cinerea, Penicillium chrysogenum, Cryptococcus albidus, Bacterium proteus, Escherichia coli, Aerobacter aerogenes and Streptomyces lavendulae preferably ATCC 21138. Preferably an aqueous solution of 6-aminopenicillanic acid is prepared by incubating an aqueous solution of the natural pencillin or a salt thereof in a concentration of 2 to 15% with the whole or crushed cells of penicillin amidase-producting bacteria or fungi or with the water-soluble penicillin amidase obtained therefrom, in the presence of at least 0-5 moles of an active hydrazide per mole of penicillin at a pH from 6-0 to 11-0, at 10 to 60 C. for 2 to 24 hours. The 6-amino-penicillanic acid produced may be purified by solvent extraction, precipitation of impurities by addition of a non-solvent and chromatography, e.g. over an ion exchange resin.
Patent ES-361909-A1 (ES)
Title: Detergent compositions containing enzymes
IPC: C11D3/386
Filed: 1968-12-27
Abstract: A detergent composition comprises (A) an organic surfactant, (B) a proteolytic enzyme and (C) one or more antimicrobial agents selected from pyridine-thione salts, inorganic mercuric compounds containing halogen, inorganic mercuric compounds containing a cyanide group, organic mercury compounds, bis-phenols and salts thereof, halogenated phenols and their salts, halogenated salicylanilides, halogenated phenyl ureas, quaternary ammonium salts, 8-hydroxy-quinoline and salts thereof, boric acid and boric anhydride. Component (A) may be anionic, cationic and non-ionic synthetic detergents and soaps. Preferred enzymes are subtilisins. Optional ingredients are "builders" such as phosphates, polyphosphates, silicates, carbonates, bicarbonates, borates, sulphates and chlorides sequestering agents, e.g. sodium nitrilotriacetate sodium carboxymethylcellulose and polyvinylpyrrolidone.
Patent ES-366200-A1 (ES)
Title: Insulated gate field-effect transistor with opposite-type gate connected region inset in source or drain
IPC: G11C19/18
Filed: 1969-04-18
Abstract: An IGFET with diffused source and drain regions of one conductivity type has formed in one of these regions a further diffused region, of the opposite conductivity type. The further region is directly connected to the gate electrode. In use as a Miller integrator with square wave input and saw tooth output the (reverse-biased) junction provided by the further region and the region (drain) containing it is used as the feedback capacitor. In use as an amplifier the region containing the further region is the source and the reverse-biased junction formed by the further region acts as a protective diode in a parallel with the gate insulation.
Patent ES-370591-A1 (ES)
Title: Icecream dispenser
IPC: A23G9/28
Filed: 1969-09-18
Abstract: A housing is formed with a cylinder and with an inlet opening communicating with said cylinder. A stationary wall extends across the cross-section of said cylinder and is spaced from said inlet opening in the axial direction of said cylinder. The housing and wall are formed with an inlet opening which communicates with said cylinder and is spaced from said inlet opening in the axial direction of said cylinder on the same side of said inlet opening as said wall. A discharge piston is slidably mounted in said cylinder for movement between first and second limiting positions and arranged to define with said stationary wall a metering chamber which communicates with said inlet and outlet openings when said piston is in said first limiting position and to engage said stationary wall and close said inlet opening when said piston is in said second limiting position. A valve is arranged to control said outlet opening, closing it when the piston is withdrawn to unblock the inlet opening.
Patent ES-380623-A1 (ES)
Title: Hydraulic power transmissions
IPC: F16H39/02
Filed: 1970-06-10
Abstract: The present invention relates to a hydraulic power transmission constituted by two groups of hydraulic motors by at least one source of pressurized fluid feeding the motors of the first group, while, concomitantly, the motors of the second group are driven by their shaft, and by a first speed limiter arranged on the delivery conduit of the first group of motors, wherein the motors of the second group having a "free wheel" function and being connected to ensure this function, a conduit connects the delivery of the first group of motors to the feed of the second group of motors and is connected upstream of the first speed limiter, while a second speed limiter is arranged downstream of the point of connection of the conduit, in the irrigation circuit of the motors of the second group.