baber/WOPTO huggingface dataset:
Patent WO-03095429-A1 (WO)
Title: Wirkstoffe zu therapie, diagnostik und prophylaxe von erkrankungen, bei denen abnorme proteinstrukturen auftreten
Inventor: SCHRADER THOMAS
IPC: C07D231/40
Filed: 2003-05-09
Abstract: Die vorliegende Erfindung betrifft Erkrankungen, bei denen abnorme Proteinstrukturen auftreten. Zu diesen zählen beispielsweise die Alzheimer'sche Krankheit, die Creutzfeld-Jakob-Krankheit, BSE und andere Prionenkrankheiten. Aufgabe der vorliegenden Erfindung ist es, neue Wirkstoffe bereitzustellen, die die Bildung von Amyloid-Plaques verhin­dern und bereits bestehende Plaques auflösen und zu Therapie, Diagnostik und Prophylaxe von Erkrankungen mit abnormen Proteinstrukturen verwendet werden können. Diese Aufgabe wird erfindungsgemäß gelöst durch heterocyclische oder aromatische Wirkstoffe mit einer starren Struktur und einem Donor-Akzeptor-Donor-Muster (DAD) an Wasserstoffbrückendonoren und -akzeptoren, die der ß-Faltblattstruktur des Proteins oder Peptids entsprechen und dadurch passen. Die heterocyclischen oder aromatischen Wirkstoffe liegen mindes tens als Dimere vor. Sie erkennen Peptide und Proteine mit ß-Faltblattstruktur, bilden stabile Komplexe mit ihnen und verhindern deren Aggregation zu ß-Amyloid-Plaques. Darüber hinaus lösen sie bereits bestehende ß-Amyloid-Plaques auf. Eine weitere Aufgabe der Erfindung ist es, Syntheseverfahren zur Herstellung der heterocyclischen oder aromatischen Wirkstoffe bereitzustellen.
Patent WO-2004096500-A1 (WO)
Title: Elektrische handwerkzeugmaschine mit akkupack
Inventor: HOFMANN ALBRECHT
IPC: H01M50/247
Filed: 2003-12-11
Abstract: Die Erfindung betrifft eine Handwerkzeugmaschine (2) mit einem Gehause (6), einem im Gehause (6) untergebrachten Elektromotor and einem mit dem Gehause (6) verrastbaren Akkupack (4) zur Speisung des Elektromotors mit elektrischem Strom. Es ist mindestens ein zwischen dem Akkupack (4) and dem Gehause (6) der Handwerkzeugmaschine (2) angebrachtes Feder-/Dampfungselement (38) zur Dampfung von Vibrationen and zur Beseitigung eines verrastungsbedingten Spiels zwischen dem Akkupack (4) and dem Gehause (6) vorgesehen.
Patent DE-1801131-A1 (DE)
Title: Liquid metal syphon for induction furnaces
Inventor: BROKMEIER DR-ING KARL-HEINZ
IPC: F27D3/08
Filed: 1968-10-04
Abstract: Induction heated crucible furnace has lid with filler opening and lid with at right angle a pouring spout and the furnace is provided with an electromagnetic liquid metal pump syphon extending under the melt level. Specif., the syphon is at an angle of 45-135 degrees to the pouring spout and the tilting axis of the furnace is slightly above the inlet of the syphon. Pref. a funnel reaching into the melt is provided in the lid of the furnace. Construction enables melt to be removed from oven without slag inclusion.
Patent DE-1801723-A1 (DE)
Title: Chromium cyclooligomerisn
Inventor: ROBERT OLECHOWSKI JEROME
IPC: C07F11/00
Filed: 1968-10-08
Abstract: Prep. of cyclo-oligomers of conjugated aliphatic dienes, e.g. cyclododecatriene, from a diene e.g. 1,3-butadiene, using a catalyst consisting of a complex Cr subhalide or a mixture of Cr zero complex and a halogenating agent. Free choice of reducing agent, e.g. aluminium triethyl. (i) Reaction temp. varies between room temp. and 100 deg. C. pref. in inert solvent (ii) Quantity of catalyst used 0.01 mole arrow right 1 mol Cr per mol diene. Continuous or batch reaction. (iii) Complex Cr subhalide has Cr oxidation state O or I. Digand is devis acid, pref. aromatic, e.g. dibenzene-Cr (I) -Iodide. (iv) Cr (0) complex contains an aromatic devis. acid as digand, plus halogenating agent e.g. dibenzene-Cr (0) plus I, BCl3 or NCl3 etc.
Patent DE-1909493-A1 (DE)
Title: Centrifugal filter
Inventor: HANL ALFRED
IPC: B01D45/14
Filed: 1969-02-26
Abstract: A driven rotating drum, mounted in the filter housing has its envelope and/or one end as a filter element, the other end contng. the discharge. This connects the interior of the drum with a discharge chamber, opposite to the chamber contng. the inlet, and sealed between the filter element and the housing. The drum axis is vertical. An annulus in the seal passes medium from the discharge chamber to the other chamber.
Patent DE-1920120-A1 (DE)
Title: Automatic transfer device for pre-finished - goods on a flat weft knitting machine
Inventor: VOIGT HEINZ
IPC: D04B15/00
Filed: 1969-04-21
Abstract: The knitted article is transferred from a comb (I) to the loom needles by means of a transporter (2) which carries (I) to a transfer location and back. A pusher transfers the goods from the magazine comb to (I). The grippers of (I) secure and lock (I) to (2) when (I) is in the transfer position. Specifically, the pushers carrying the magazine comb are pushed on rails and stopped in transfer position by a knitting head. The transporters are two pivotal levers fitted on both sides of the knitting head.
Patent DE-1922949-A1 (DE)
Title: Process and equipment for burning oxidis- - able materials in waste gas
Inventor: K BETZ WILHELM
IPC: B01D53/34
Filed: 1969-05-06
Abstract: A heat exchanger is positioned in the lower portion of a burner assembly so that part of the incoming gas is heated to at least 200 degrees C, resulting in the commencement of oxidation inside the heat exchanger. The two primary burners are set tangentially in the body above the heat exchanger so that the preheated partly oxidised gas passes through the burning zone in a spiral path into the top of the burner chamber which may contain a catalyst bed, returning through a peripheral annular space to the heat exchange for discharge. The configuration of the burners in the body ensures thorough mixing of gases, and increases the burning effectiveness. Overheating is prevented by adding dilution air at the top of the chamber. The whole burner assembly is smaller than comparable duty equipment. The gas residues can be organic such as hydrocarbons, or inorganic such as hydrogen sulphide.
Patent DE-1927565-A1 (DE)
Title: Coating a textile strip such as tufted - carpet material with a flowable coating
Inventor: FLEISSNER HANS DIPL ING
IPC: D06B1/06
Filed: 1969-05-30
Abstract: In a device for coating a strip of textile material with e.g. a dye liquor, as in DT 1810361, there is arranged in front of the bath a filling bath of equal width having a feed pipe for topping up the bath with coating material. The filling bath has an overflow rim which is above the dye liquor level in the coating bath.
Patent DE-1927578-A1 (DE)
Title: Roller drier with a screening drum under - suction draught
Inventor: HANS FLEISSNER DIPL-ING
IPC: F26B13/16
Filed: 1969-05-30
Abstract: The screening drum transports material being processed and has nozzles arranged around it, as well as a ventilator on its face for circulating a treatment medium. The nozzles are connected to the blowout openings of the ventilator or the ventilator chamber. The screening drum has openings or is open on the opposite side of the drum to the ventilator to draw in the treatment medium which is blown onto the material.
Patent DE-1955245-A1 (DE)
Title: Xylitol preparation for intravenous injec - tion
Inventor: ANTHONY PARKER EUGENE
IPC: A61K47/18
Filed: 1969-11-03
Abstract: Xylitol preparation for intravenous injection consists of xylitol, (5-50 parts wt.), and tris(hydroxymethylamino)methane, (0.01-1 part wt), in a physiologically acceptable solvent, particularly water or M NaCl containing sufficient acetic acid to give pH 7.2-7.6. The product is a valuable nutritional aid.
Patent DE-2012720-A1 (DE)
Title: Protective layers for nuclear fuels by car-bide deposition
IPC: G21C3/62
Filed: 1970-03-17
Abstract: Layer of one or more high-melting polycrystalline, highly pure N and/or O-containing carbides is precipitated from a reactive gas-phase at raised temp. directly onto nuclear fuel particles or on a layer surrounding them, and subsequently freed from its carbide-forming partner, as well as N and/or O, completely or in part, with halogen or volatile halogen cpds at raised temps. Dense, hard but fissionable fuel-retaining layer mainly formed of amorphous C is obtained, and subsequently re-coated with high-melting polycrystalline carbide/s. Pref. high-melting carbides of Si or B and/or T-metals esp Ti, Zr, Th are used and deposited at 1000-1600 degrees C or pref. complex carbides are used, alone or in alternating layer sequence with the high-melting carbides cited.
Patent DE-2019176-A1 (DE)
Title: Alkylcobalamine prepn
Inventor: TOHDA MINORU
IPC: C07H23/00
Filed: 1970-04-21
Abstract: Process comprises reacting hydroxocobalamine or its salt with alkyl halide in the presence of a cpd. contg. hydrazino gp.
Patent DE-2115534-A1 (DE)
Title: Filter layer - esp for land drainage pipes using acrylic filter material
Inventor: RIPKEN, FRIEDRICH
IPC: B01D39/08
Filed: 1971-03-31
Abstract: The inner layer of filter material around the slotted land drainpipes is protected by an outersheath of organic textile material which rots away after a given length of burial in the ground. The filter layer proper is of an acrylic material and remains stable after rotting of the sheath.
Patent DE-2145308-A1 (DE)
Title: 4-(4-hydrophenyl)-butan-2-one prodn - by reaction between phenol and 4-hydroxybutan-2-one in presence of strong acid
Inventor: FISCHER ROMAN DR
IPC: A23L27/20
Filed: 1971-09-10
Abstract: Title cpd. is an aroma agent having the scent and taste of raspberries. It is produced in high yields by the one-stage title process which is much simpler and cheaper than the known production methods because inexpensive starting materials are used. The reaction is carried out at -10 degrees to +80 degrees C (preF. between -2 degrees and +30 degrees C) in the presence of conc. H2SO4 or H3PO4, or gaseous HCl in a solvent.
Patent DE-2150725-A1 (DE)
Title: Platinum-rhodium recovery in gaseous form lost in the - oxidation of ammonia - use of a getter and mechanical filter
Inventor: HOLZMANN HERMANN DR
IPC: C22B11/02
Filed: 1971-10-12
Abstract: Wire grids of Pt-Rh are normally used as catalyst in the combustion of ammonia involving a considerable loss in gaseous Pt-Rh. The Pt-Rh is recovered by the use of a getter in the form of a wire grid composed of a Pd-Au alloy contg. 10-40% Au or pref. a 80% Pd-20% Au alloy located immediately behind the catalyst together with a mechanical filter of glass wool placed in the zone where the temp. is below 400 degrees C.
Patent DE-2212038-A1 (DE)
Title: Synthetic resin moulded parts - with low specific weight hollow filler bodies in a homogeneous compsn
Inventor: DUNKEL WOLFHART DR RER NAT
IPC: C08J9/32
Filed: 1972-03-13
Abstract: The resin substance filled with hollow bodies is rapidly hardened using heat and pressure. Pref. hollow balls of defined varying sizes are used to produce a high filling factor with the balls coated with a bonding agent which accelerates the setting of the resin substance.
Patent DE-2222548-A1 (DE)
Title: Cutting rolled material - on revolving shaft which swings horizontally to insert and remove roll
IPC: B65H35/04
Filed: 1972-05-08
Abstract: An appts for cutting a roll of strip or sheet material mounted on a rotationally driven shaft utilises a cutting tool mounted upon a lever which pivots about an axis parallel to the rotational shaft; the rotational shaft itself can be pivoted about a vertical axis. The cutting blade is pref. coated with PTFE. Enables the roll to be easily inserted and removed, so that the machine can be operated by one man.
Patent DE-2225794-A1 (DE)
Title: Titanium dioxide prodn - in oxygen plasma arc by oxidation of titanium tetrachloride
Inventor: MILKO WALENTIN IWANOWITSCH
IPC: C01B13/28
Filed: 1972-05-26
Abstract: The temp. of the mass in the reaction zone is reduced from 1300-6500 degrees C to 1000-1900 degrees C, and the TiCl4 is fed in liq. from into the plasma of the O2 or O2 contg. gas. Pref. the liq. TiCl4 is fed together with AlCl3 vapour present in amts. of 1-4% w.r.t. TiCl4 wt.
Patent DE-2235065-A1 (DE)
Title: Remote drum handling gear - with latched spring plungers for lid flange
Inventor: SELIG MANFRED
IPC: G21F7/06
Filed: 1972-07-17
Abstract: The lid flange is reversed i.e. inwards, and the spring plungers esp. three, have tapered ends with radiused tips and are mounted in a flat dish housing whose O/D is a little less than the I/D of the flange. The inner end of each plunger is cut away to leave a stop lug at the lower side and a mushroom heat on an axial plunger can be lowered onto those stops to latch the lifting plungers in their radially outermost position. Esp. for radio-active waste disposal etc.
Patent DE-2241993-A1 (DE)
Title: Phosphonic acid dihalides - inters for pesticides growth regulators and flame retardants
Inventor: FINKE MANFRED DR
IPC: C07F9/42
Filed: 1972-08-26
Abstract: Dihalides RP(O) Hal2, where R = (2-18C) alpha, beta-unsatd. alkenyl (3-10C) alpha, beta-unsatd. cycloalkyl, Ph or PhCH2 all opt subst. by Cl, Br, alkyl, O alkyl, CN or CF3 are prepd. by reacting a phosphoric or pyrophosphoric acid of formulae: or there monothio analogues or derivs with (CO)nHal2, where n = 1 or 2, opt. in a solvent at 65 degrees 200 degrees. A polymsn. inhibitor is pref. added if R = alkenyl.
Patent DE-2248398-A1 (DE)
Title: Control rod restraint and lock - for cassette fuelled boiling water reactor
Inventor: BERGLUND AAKE
IPC: G21C7/117
Filed: 1972-10-03
Abstract: Control rod restraint and locking system applicable to boiling water reactors using cassette type fuel element cores. The control rods are arranged in a precise geometric configuration within the cassette on radial arm supports and are locked at the base in bayonet type fixings. Inadvertent release or rotation is inhibited by a spring loaded sleeve at the upper end of the rod which incorporates a rectangular collar locating in the rectangular tube encasing the rod. A tubular control rod casing can be used with a modified locking sleeve. Release is effected by raising the spring loaded sleeve which enables the bayonet locked rod to be turned and withdrawn.
Patent DE-2310262-A1 (DE)
Title: Determination of thread breakage - partic for embroidering machine with automatic colour change
IPC: D05C11/14
Filed: 1973-03-01
Abstract: Determination of thread breakage is effected by a separator which disengages all rocker arms carrying electrical contacts at the beginning of each colour-changing or ratio-changing operation. The rocker arms are again put into operation immediately afterwards by terminals, and the needles are brought into action again by a connector which responds to thread tension for activation.
Patent DE-2311780-A1 (DE)
Title: Wave shed loom magnetic shuttle drive - with friction force between shuttle and shedding mechanism eliminated
Inventor: KAMANCZYK PRZEMYSLAW STANISLAW
IPC: D03D49/44
Filed: 1973-03-09
Abstract: At reat, the shuttle magnet assembly of magnets polarised perpendicularly to the direction of movement, alternately polarised, lie over, and are attracted to, the similarly arranged driver part, with a small air gap between. The driver perpendicularly orientated magnets are smaller and between them have magnets polarised in the motion direction, whose poles are, on the air gap side, arranged with like poles of the perpendicularly orientated magnets. When the driver moves, its poles are displaced to come towards like poles of the shuttle magnets, which repel, giving not only driving force but also separating force levitating the shuttle to eliminate friction.
Patent DE-2313090-A1 (DE)
Title: Laboratory flask stopper and tube with good seal - form interchangeable two part unit to receive stirrer shaft
Inventor: SCHLEE KARL
IPC: B01L3/00
Filed: 1973-03-16
Abstract: A closure for glass instruments, esp. for sealing the mouth of a laboratory flask fitted with a stirrer, comprises an externally conical plug through which a glass tube passes to take the coaxial stirrer shaft. The plug has a central passage through it into which the glass tube fits to constitute a ttwo-component unit; external serrations on the tube and internal serrations on the plug, esp in the form of screw threads, lock the plug and tube together and constitute a seal between them. The plug is pref. of F-contg. polymer. This arrangement enables the stopper and/or tube to be separately interchanged, while at the same time providing a better seal than a conventional glass tube passing through a cork.
Patent DE-2315935-A1 (DE)
Title: Imidazole derivs. and prodn. from aldehyde - by reacting with ammonia and hydrogen cyanide and ring closure
Inventor: GHYCZY MIKLOS DIPL CHEM DR
IPC: C07D233/58
Filed: 1973-03-30
Abstract: These derivs. have the formula (I): (in which R1 and R2 are each opt. substd. aliphatic and/or aromatic gps) and are produced by (a) reacting an aldehyde R1(R2)CH-CHO with NH3, opt. in the presence of an inert org. solvent forming an azeotrope with water, under reflux conditions, with simultaneous removal of the water of reaction, (b) reacting the resultant prod. R1(R2)C=CH-N=CH-CH(R2)R1 with HCN at relatively low temp. opt. in the presence of an inert solvent, and (c) subjecting the reaction prod. (R2)(R1)CH-(CN)C=N-CH2-CH- -(R1)(R2) to a ring closure reaction to the correspn. imidazole deriv. in a polar inert solvent in the presence of HCl. The prods. are used in pharmacy, as plastics stabilisers and as inters. for polyurethane cross-linking agents, and have quasiaromatic character and interesting props. Only an aldehyde, NH3 and HCN are needed as starting materials.
Patent DE-2325314-A1 (DE)
Title: Polystyrene-polybutadiene block copolymers prodn - by block copolymsg. butadiene and styrene onto living poly-alpha-methyl styrene block, with good thermal stability
Inventor: SCHATALOW WALENTIN PAWLOWITSCH
IPC: C08F297/04
Filed: 1973-05-18
Abstract: Thermally stable block copolymers of the type ABC, where A is a poly-alpha-methyl styrene block, B is a polybutadiene block and C is a polystyrene block are made by polymerising the alpha-methyl-styrene either in the mass or in a hydrocarbon soln, using a concn of not less than 50 wt.% in the presence of sec. butyl lithium at a temp. of 0-50 degrees C whereby a living block A is produced onto which a diene hydrocarbon block and styrene is polymerised at 40-80 degrees C.
Patent DE-2328255-A1 (DE)
Title: Cold storage system - for fish without damaging texture
Inventor: ERIKSEN JAN BERGH
IPC: A23B4/06
Filed: 1973-06-02
Abstract: The fish are unloaded from nets, trays, etc., into a travelling hopper and thence into the inlet ends of a number of sloping, rectangular, thin walled tubes through which a continuous flow of coolant is passed, which are progressively filled up with fish so reducing the coolant flow. At their lower ends they have mesh covers to retain the fish and allow the coolant to drain and the tops of their lower wall are esp. grooved axially to allow coolant to flow under the lower surface of the fish.
Patent DE-2329911-A1 (DE)
Title: Press-stud insertion of bearing rings in inclined ball bearings - moulded lips formed on the plastic roller body cage
Inventor: SCHWARZBICH JOERG
IPC: F16C33/80
Filed: 1973-06-12
Abstract: Roller bearings, esp. inclined ball bearing allowing all the advantages of press-stud insertion of the bearing rings onto the lips formed as one piece with the roller body cage. One of the 2 mouldings of the cage lies above or outside and the other lies below or inside the part circle of the bearing. The lips are formed as one piece with the moulding of the bearing cage for the press-stud insertion of the bearing rings and lie inside the space between the two bearing rings. The material of the bearing rings is pref. comparable in strength and elasticity to that of polyamide.
Patent DE-2330266-A1 (DE)
Title: Multi-objective camera - has objectives mounted on slider for compact layout
Inventor: ETTISCHER HELMUT
IPC: G03B17/42
Filed: 1973-06-14
Abstract: The camera has a compact shape and uses casette film. The different objectives are mounted on two sliders. One is behind the shutter to hold the 'Standard' and 'Wide Angle' lenses and one slider is in front of the shutter to hold the 'Telephoto' attachment. The lenses are flat proiled and their operating sliders also control the focussing automatically when altering the objective. The sliders have flanges to carry symbols indicating the position of the objective.
Patent DE-2331248-A1 (DE)
Title: Production of fused doped contact between electrode and semiconductor - multilayer assembly of electrode metal and doping material fused to surface
Inventor: AKIMOW JURIJ STEPANOWITSCH
IPC: H01L21/24
Filed: 1973-06-19
Abstract: A production method for a fused, alloyed contact between an electrode metal and a semiconductor, in which the electrode metal is fused in a melt containing the metal and a dope material at a temp. not lower than the melting temp. of the eutectic mixture of electrode metal and semiconductor material, which is obtained by heating a multi-layered structure of such form that a metallic layer of very small thickness is deposited on the semiconductor surface which can reduce oxides on the semiconductor on heating. This layer is covered with an electrode metal layer and then with successive layers of doping material and electrode metal. Electrode metal layer thickness is approx. 95-99% of the total multi-layered thickness.
Patent DE-2337978-A1 (DE)
Title: Antistatic yarn - includes metal fibres of polygonal section with sharp corners
Inventor: HAMADA KOICHI
IPC: D02G3/44
Filed: 1973-07-26
Abstract: A substantial number of the metal fibres are at the exterior of the yarn, pref. in clusters or surrounding clusters of nonmetal fibres, and some metal fibres extend along the yarn.
Patent DE-2339541-A1 (DE)
Title: Absorption of oil slicks from water - using barriers of oleophilic materials to protect coastlines, etc
Inventor: PROC PETER HOFHEIM
IPC: E02B15/04
Filed: 1973-08-04
Abstract: Sections of beaches, coastlines, etc. are protected against pollution by floating oil slicks, by fixing the oil on surfaces of oleophilic materials, pref. polyolefines (esp. low-molec. high pressure PE) or rubber. Pref. floating barriers made of, or filled with oleophilic materials are used. These are of elongated shape and several may be joined to enclose a protected area. Oil is removed instead of being sunk or emulsified by detergents with associated ecological risks. Contamination of beaches with oil-soaked straw, sawdust, etc. used for absorption, is avoided.
Patent DE-2355055-A1 (DE)
Title: Continuous grinding of solids - suspended in a liquid by passage through an agitated bed
Inventor: SZEGVARI ANDREW
IPC: B02C17/16
Filed: 1973-11-03
Abstract: Material to be ground is suspended in a liquid in a holding vessel. It is pumped through an agitated bed of pieces of grinding medium. At rest the medium occupies >=85% of the volume of the bed. The rate is sufficient to displace the liquid in the bed >=30 pref. 50-300 times per hr. The superficial velocity is >=2 pref. 5-50 mm per sec. Several passes through the bed are needed to reach the required particle size. There is a retaining screen at the bed outlet and the liquid preferentially passes upwards through it.
Patent DE-2407286-A1 (DE)
Title: Cardboard pieces for cct. diagram production - represent cct. symbols and contain iron for holding to magnetic sheet
Inventor: FLEISCHER HANS
IPC: G03G15/22
Filed: 1974-02-15
Abstract: The system produces circuit diagrams economically by attaching cut-out symbols of the circuit components to cardboard pieces containing iron particles. The symbols with their cardboard backings are then placed on a flexible permanently-magnetic sheet which holds them in the required positions. The connecting lines between the symbols are then filled in by hand. The completed circuit is then photocopied. The advantage of this method lies in its being able to re-use the circuit symbols, which is most cases are standard, e.g. an operational amplifier in integrate circuit form, only the interconnecting wires being moved.