baber/WOPTO huggingface dataset:
Patent WO-2019195738-A1 (WO)
Title: Compositions and methods for somatic cell reprogramming and modulating imprinting
Inventor: ZHANG YI
IPC: C12N15/877
Filed: 2019-04-05
Abstract: The invention provides methods for improving cloning efficiency and modulating an imprinting control region. In particular embodiments, the invention provides methods for activating a repressed allele within an imprinting control region, thereby treating an imprinting associated disorder. In other embodiments, the invention provides methods for improving somatic cell nuclear transfer efficiency that involve  Kdm4d  overexpression is a  Xist  knockout donor cell.
Patent WO-2019199684-A1 (WO)
Title: Methods and systems for biocellular marker detection and diagnosis using a microfluidic profiling device
Inventor: GOONESWARDENA SASCHA
IPC: G01N33/561
Filed: 2019-04-08
Abstract: The present disclosure relates to the use of microfluidic devices and systems to generate dynamic molecular signatures based on the detection of various biocellular markers. In particular, the present disclosure involves generating a dynamic molecular signature or profile using the cells of a subject (e.g., circulating monocytes), for various diagnostic and prognostic purposes, such as characterizing a disease or non-disease state, or predicting drug responsiveness. The microfluidic systems and methods of the present disclosure can be used to rapidly assess a plurality of clinical characteristics, which will ultimately enhance therapeutic efficacy and facilitate disease risk stratification.
Patent WO-2019199735-A1 (WO)
Title: Long-range laser rangefinder
Inventor: MARYFIELD TONY
IPC: F41G3/26
Filed: 2019-04-09
Abstract: A laser rangefinder system 110 utilizes a laser transmitter assembly with a fiber laser for generating a plurality of laser pulses 210 that are reflected off of a target 200 and received at a light receiver assembly that includes a light detector for detecting the reflected laser pulses 210. The plurality of reflected laser pulses are then used to determine an accurate distance from the laser rangefinder system 110 to the target 200. This can include taking an average of the distances calculated using each of the plurality of reflected laser pulses. Laser rangefinders 110 can be mounted to and used in conjunction with another apparatus, such as a weapon 120 and/or optical scope 130. This ensures the accuracy of range measurements taken by a laser rangefinder 110 with respect to the target 200. The laser rangefinder system 110 can additionally provide a ballistic solution. As such, environmental information is obtained from an environmental sensor and a ballistic solution is determined based on the determined distance from the target and on the information from the environmental sensor. The environmental sensor itself may comprise one or more types of sensors to sense one or more types of environmental factors. The environmental sensor may comprise an inclinometer, thermometer, barometer, humidity sensor, compass, wind sensor, or any combination thereof. A display of the laser rangefinder system 110 may show the ballistic solution.
Patent WO-2019200151-A1 (WO)
Title: Handheld symbol reader with optical element to redirect central illumination axis
Inventor: DRZYMALA MARK
IPC: G06K7/10
Filed: 2019-04-11
Abstract: An apparatus and assembly for redirecting the central illumination axis of an illumination assembly towards the central field of view (FOV) axis of an imaging assembly using an optical element that provides an optical magnification of less than 1.5x, where the central illumination axis at the point of the illumination assembly is non-parallel to the central FOV axis.
Patent WO-2019209779-A1 (WO)
Title: Rheological modifiers for spray drift control in agrochemical emulsions
Inventor: GRZESIAK ADAM L
IPC: A01N25/04
Filed: 2019-04-23
Abstract: The present disclosure provides for an agrochemical emulsion with reduced spray drift that includes an emulsion pre-mix concentrate, an acrylate-based copolymer, and an aqueous based agrochemical composition. The agrochemical emulsion includes 0.05 to 5 weight percent (wt.%) of the emulsion pre-mix concentrate, 0.05 to 5 wt. % of the acrylate-based copolymer and 90 to 99.9 wt.% of the aqueous based agrochemical composition. The emulsion pre-mix concentrate includes 40 to 70 wt.% of an alkylene glycol ether, 10 to 40 wt.% of a vegetable-oil, and a surfactant, where the wt.% of the surfactant is 0.5 to 2 times the wt.% of the vegetable-oil wt.%, where the wt.% values are based on the total weight of the emulsion pre-mix concentrate and the wt.% of the alkylene glycol ether, the vegetable-oil and the surfactant total 100 wt.% of the emulsion pre-mix concentrate. The acrylate-based copolymer has a weight average molecular weight of 0.5 to 1.5 million.
Patent WO-2019236496-A1 (WO)
Title: Pyrimidine compounds containing acidic groups useful to treat diseases connected to the modulation of tlr7
Inventor: WU TOM YAO-HSIANG
IPC: A61K31/506
Filed: 2019-06-03
Abstract: The present disclosure relates to a class of pyrimidine derivatives of formula (I) having immunomodulating properties that act via TLR7 which are useful in the treatment of lung cancer and other respiratory conditions.
Patent WO-2019241216-A1 (WO)
Title: Multi-specific antibody constructs
Inventor: SHORT JAY
IPC: A61P35/00
Filed: 2019-06-11
Abstract: A multi-specific antibody contains at least one binding site for a cell specific antigen and at least one binding site for a tumor-reactive lymphocyte antigen and a multi-specific antibody including an IgG antibody or fragment thereof that binds to a first antigen; and at least one scFv antibody that binds to a second antigen that is different from the first antigen and is linked to a C terminus of at least one light chain or heavy chain of said IgG antibody or fragment. The multi-specific antibody reversibly binds to at least one of the cell specific antigen and tumor-reactive lymphocyte antigen or the first antigen and the second antigen with a greater affinity at an aberrant condition than at a normal physiological condition. Conjugates of the multi-specific antibodies and methods for generating the multi-specific antibody are also provided.
Patent WO-2019246077-A1 (WO)
Inventor: STANLEY JUSTIN
IPC: H04L9/36
Filed: 2019-06-18
Abstract: Multivariate encryption systems and methods are provided herein. An example method includes receiving a multivariate input set that includes a plurality of sensitive data objects arranged according to a record template, encrypting the multivariate input set into an encrypted representation, receiving a request for at least a portion of the plurality of sensitive data objects, extracting the at least a portion of the plurality of sensitive data object from the encrypted representation and generating a response message that includes only the at least a portion of the plurality of sensitive data objects that were extracted from the encrypted representation.
Patent WO-2019246387-A1 (WO)
Inventor: RICARDO ALONSO
IPC: A61K38/08
Filed: 2019-06-20
Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.
Patent WO-2020005815-A1 (WO)
Title: Miniaturized intra-body controllable medical device employing machine learning and artificial intelligence
Inventor: VELIS CHRISTOPHER J P
IPC: A61B1/00
Filed: 2019-06-24
Abstract: A medical system includes one or more medical devices for intra-body conveyance which include a host structure that defines an interior area, one or more data gathering system, one or more means for communication, for transmitting data from the data gathering systems. The medical device is configurable into a peripheral boundary of a size adapted to fit in a lumen of a living organism. The medical system includes an external processing device configured to receive the transmitted data from the means for communication. The external processing system is configured to perform data analysis on the data received from the medical device.
Patent WO-2020005865-A1 (WO)
Title: Methods and apparatus to adapt medical imaging user interfaces based on machine learning
Inventor: JOY MANUEL
IPC: G16H30/40
Filed: 2019-06-25
Abstract: Methods and apparatus to adapt medical imaging interfaces based on learning are disclosed. An example apparatus includes a use monitor to monitor, in a first session, user actions and medical content data pertaining to operation of a clinical image display, a learning device including a processor to implement a learning network to develop a model for a subsequent session based on the user actions in relationship to a context of the medical content data. The model developed by defining contextual patterns of the user actions based on the context and the medical content data. The learning device is to update, prior to or during a second session subsequent the first session, a user interface based on the model.
Patent WO-2021002853-A1 (WO)
Title: Multi-agent, multi-objective wellbore gas-lift optimization
Inventor: MADASU SRINATH
IPC: E21B41/00
Filed: 2019-07-02
Abstract: A system and method for controlling a gas supply to provide gas lift for wellbore(s) using Bayesian optimization. A computing device controls a gas supply to inject gas into wellbore(s). The computing device receives first reservoir data associated with a first subterranean reservoir and simulates production using the first reservoir data, using a model for the first subterranean reservoir. The production simulation provides first production data. The computing device receives second reservoir data associated with a subterranean reservoir and simulates production using the second reservoir data, using a model for the second subterranean reservoir. The production simulation provides second production data. A Bayesian optimization of an objective function of the first and second production data subject to any gas injection constraints can be performed to produce gas-lift parameters. The gas-lift parameters can be applied to the gas supply to control injection of gas into the wellbore(s).
Patent WO-2020010275-A1 (WO)
Title: Physical parameter measuring devices
Inventor: LEE RANDALL J
IPC: A61B5/024
Filed: 2019-07-03
Abstract: Described herein are devices, systems, and methods for sensing a physical parameter of an individual. In some embodiments, a physical parameter of an individual comprises an ECG sensed from the individual. In some embodiments, a physical parameter comprises a heart rate of an individual. In some embodiments, a physical parameter comprises a blood pressure of an individual. Generally, devices, systems, and methods described herein for physical parameter measurement include an application specific integrated circuit configured to facilitate effective physical parameter measurement.
Patent WO-2020014620-A1 (WO)
Title: Expression-based diagnosis, prognosis and treatment of complex diseases
Inventor: LEWIS NATHAN
IPC: C12Q1/68
Filed: 2019-07-12
Abstract: The invention provides for the detection of a perturbed gene network, which includes highly expressed genes during fetal brain development, which is dysregulated in neuron models of autism spectrum disorder (ASD). High-confidence ASD risk genes are upstream regulators of the network modulating RAS/ERK, PI3K/AKT, and WNT//β-catenin signaling pathways. The invention demonstrates how the heterogeneous genetics of ASD can dysregulate a core network to influence brain development at prenatal and very early postnatal ages and, thereby, the severity of later ASD symptoms. The invention provides a model for diagnosis, prognosis determination, and optionally treatment and monitoring, for any disease by comparing molecular marker patterns in non-affected tissues in a subject with healthy controls to determine a dysregulated network in the subject based on a co-expression pattern of interacting genes.
Patent WO-2020033545-A1 (WO)
Title: Carbonated frozen dessert
Inventor: DUNN MICHAEL
IPC: A23G9/04
Filed: 2019-08-07
Abstract: Hardpack frozen desserts providing a carbonation sensation even after frozen storage over an extended shelf life, and methods of making such hardpack frozen desserts are described. Hardpack frozen desserts have a particular solute content, providing a solute molarity of at least 1.0 molar, and/or a solute molality of at least 0.78 molal, and/or an Aw of the mixture of 0.91 or less.
Patent WO-2020033591-A1 (WO)
Title: System and method for sharing subscriber resources in a network environment
Inventor: GHOSH AMEO
IPC: H04L12/24
Filed: 2019-08-07
Abstract: Systems, methods, and computer-readable media are provided for modifying a network service of a requesting network member. A request, received from the requesting member, can include an identification of a sponsoring network member for a requested network service modification. A group can be generated and associated with the requesting member and with the sponsoring member. The group may also include a group policy referencing the requested network service modification. The sponsoring member can be provided with an activation key for activating the network service modification and a first network policy can be applied to the requesting member and a second network policy can be applied to the sponsoring member.
Patent WO-2020055575-A1 (WO)
Inventor: PRINCE PHILIPPE
IPC: C09K8/52
Filed: 2019-08-23
Abstract: L'invention concerne des procédés impliquant des inhibiteurs d'hydrates anti-agglomérants et des hydrocarbures polyaromatiques pour l'inhibition d'hydrates. Dans certains modes de réalisation, les procédés comprennent l'introduction d'une composition d'inhibiteur d'hydrates comprenant un inhibiteur d'hydrates anti-agglomérants dans un fluide comprenant (i) l'eau et (ii) un élément parmi un gaz, un hydrocarbure liquide et n'importe quelle combinaison de ceux-ci; et l'introduction d'un hydrocarbure polyaromatique dans le fluide.
Patent WO-2021045726-A1 (WO)
Title: Systems and methods for authenticated control of content delivery
Inventor: WANG GANG
IPC: G06Q30/02
Filed: 2019-09-03
Abstract: The present disclosure provides systems and methods for authenticated control of content delivery. The method includes receiving a request for an item of content from a computing device, the request comprising a security token associated with the computing device and an identifier of a group of domains, identifying the group of domains from the identifier, and retrieving a security key associated with the group of domains. The method further includes decrypting a signature of the security token, identifying an authentication string, determining that the authentication string matches a server authentication string, and identifying characteristics of the security token. The characteristics of the security token include a confidence score. The method further includes comparing the confidence score of the security token to a threshold, determining that the confidence score does not exceed the threshold, and preventing transmission of content to the computing device.
Patent WO-2020076739-A1 (WO)
Inventor: YING QI-LONG
IPC: A61K35/15
Filed: 2019-10-07
Abstract: The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte- macrophage progenitors thereof.
Patent WO-2020081365-A1 (WO)
Title: Implant insertion device
Inventor: MOREY Subodh
IPC: A61B17/34
Filed: 2019-10-10
Abstract: According to a general aspect, an insertion device includes an elongate member defining a lumen, a handle member movably coupled to the elongate member, a plunger member, at least a portion of the plunger member being disposed within the lumen defined by the elongate member, and an actuation member operatively coupled to the plunger member, the plunger member being configured to move from a first position within the lumen to a second location within the lumen in response to the actuation member being actuated.
Patent WO-2020086571-A1 (WO)
Title: Dynamic radio frequency switching in new radio for radio resource management in radio resource control connected state
Inventor: YU ZHIBIN
IPC: H04W56/00
Filed: 2019-10-22
Abstract: Embodiments of the present disclosure describe methods, apparatuses, storage media, and systems for configuring and implementing radio resource management (RRM) measurements for monitoring neighboring cells based on synchronization signal block (SSB) timing groups in an radio resource control (RRC) connected (RRC_CONNECTED) state. Various embodiments describe how to determine a set of SSB timing groups, and how to generate a receiver switching pattern based on the set of SSB timing groups and/or SSB scanning measurements. The embodiments also describe determination and implementation of an SSB scanning mode and an SSB Other embodiments may be described and claimed.
Patent WO-2020117408-A1 (WO)
Title: Method for converting monoisocyanates to ureas
Inventor: HEFNER JR
IPC: C07C273/18
Filed: 2019-10-31
Abstract: Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets.
Patent WO-2020096962-A1 (WO)
Inventor: GRIGGS DANIEL
IPC: G06F21/50
Filed: 2019-11-04
Abstract: A computer-implemented method may be used for security event monitoring. The method may include receiving data from a first operating system and defining an audit classes data filter for collection by a security event monitoring application. Additionally, the method may include comparing the data with the audit classes data filter and comparing the data with a set of blacklisted values. Additionally, the method may include outputting a common structure format data based on the comparison of the processing data with the audit classes data filter and the blacklisted values.
Patent WO-2021091532-A1 (WO)
Inventor: COOPER MICHAEL
IPC: A61K31/55
Filed: 2019-11-05
Abstract: The present disclosure relates to the use of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide, and pharmaceutically acceptable salts thereof, for treating myelofibrosis.
Patent WO-2020117515-A1 (WO)
Title: Commercial washer, which is in the form of an under-counter machine, and method for operating such a washer
Inventor: DISCH HARALD
IPC: A47L15/42
Filed: 2019-11-25
Abstract: A commercial washer (1), in particular dishwasher or glass washer, which is in the form of an under-counter machine, has at least one treatment chamber (3) which is provided in a machine housing (2) and into and from which at least one dish rack (4) can be inserted and removed. The washer (1) furthermore has a mechanism for retracting or extending the at least one dish rack (4) into the and, respectively, out of the treatment chamber (3) as required. The mechanism has a lifting unit (5), with the aid of which a dish rack (4) which is received in the treatment chamber (3) can be transferred from the wash level (W) into a level (E) above the machine housing, and vice versa from a level (E) above the machine housing into the wash level (W). A corresponding method for operating such a washer (1) is also provided.
Patent WO-2020112906-A1 (WO)
Title: Ligands peptidiques pour la capture de protéines de cellules hôtes
Inventor: MENEGATTI STEFANO
IPC: C07K16/06
Filed: 2019-11-26
Abstract: L'invention concerne des compositions et des procédés pour éliminer une ou plusieurs protéines de cellules hôtes d'un mélange. La composition comprend un ou plusieurs peptides, chaque peptide dans la composition ayant une affinité de liaison plus grande pour l'une ou les protéines de cellules hôtes que pour une ou plusieurs biomolécules cibles.
Patent WO-2020118186-A1 (WO)
Title: Generation of electromagnetic solitons for propulsion by a rotating anisotropic homopolar magnetic field
Inventor: HAWKINS DAVID
IPC: F03H3/00
Filed: 2019-12-06
Abstract: This application describes creating, modifying, and bending electromagnetic solitons at large scales for the various applications. An electromagnetic soliton generator system controls the magnetic soliton such that the orientation, rotation rate, pitch angle, and magnetic field strength of the solitons are modified to provide the described standing waves and generate a magnetic flux differential.
Patent WO-2020131560-A1 (WO)
Inventor: RUA IGNACIO
IPC: A61M1/36
Filed: 2019-12-12
Abstract: La présente invention concerne un appareil vasculaire comprenant un greffon vasculaire et une pluralité de shunts à ballonnet. Le greffon vasculaire comprend des extrémités proximale et distale et définit une lumière. L'extrémité proximale du greffon est conçue afin d'être accouplée à un vaisseau sanguin source par une anastomose. Les shunts à ballonnet sont accouplés de manière fluidique à la lumière au niveau de l'extrémité distale du greffon vasculaire. Chaque shunt comprend un tube ayant une extrémité proximale fixée à l'extrémité distale du greffon vasculaire et ayant une extrémité distale conçue afin d'être insérée dans un vaisseau sanguin de réception, et un ballonnet entourant le tube au niveau ou à proximité de l'extrémité distale du tube. Les ballonnets se dilatent afin d'assurer l'étanchéité par rapport au vaisseau sanguin de réception. Lorsqu'il est posé par voie chirurgicale, l'appareil transporte le sang depuis le vaisseau sanguin source tel que l'aorte ou une artère axillaire vers les vaisseaux sanguins de réception tels que les artères rénales.
Patent WO-2020139655-A1 (WO)
Inventor: LIU ZHEN HUA
IPC: G06F16/80
Filed: 2019-12-18
Abstract: La présente invention concerne le réglage autonome d'une grille de données de documents dans une base de données. L'invention concerne des techniques pour des cellules de stockage pour maintenir de manière autonome des indices locaux et d'autres métadonnées d'optimisation et des algorithmes pour accélérer un accès sélectif dans une collection distribuée de documents. Dans un mode de réalisation, chaque cellule de stockage maintient un sous-ensemble respectif de documents. Chaque cellule de stockage stocke, en mémoire, un ou des index respectifs qui mappent chaque article sur un ou des emplacements, dans un ou plusieurs documents du sous-ensemble respectif de documents, où l'article se trouve. Un ou plusieurs ordinateurs exécutent, sur la base d'au moins un sous-ensemble des indices des cellules de stockage, une demande d'accès aux données en provenance d'un système de gestion de base de données. Dans un mode de réalisation, un nuage de services de documents ISON fournit une base de données de documents ISON entièrement autonome facile à utiliser qui effectue une mise à échelle horizontale et élastique pour permettre une exécution rapide de transactions et de demandes de document sans avoir besoin de réglage par un administrateur de base de données.
Patent WO-2020132274-A1 (WO)
Title: Techniques de maintenance de mémoire flash basées sur un hôte
Inventor: PALMER DAVID AARON
IPC: G06F12/10
Filed: 2019-12-19
Abstract: L'invention concerne des dispositifs et des techniques permettant une maintenance basée sur un hôte d'un dispositif de mémoire flash. Selon certains exemples, des informations d'écriture en mémoire peuvent être chiffrées au niveau du dispositif de mémoire et fournies à l'hôte pour mettre à jour et maintenir des statistiques de maintenance de dispositif de mémoire.