Patent SG-11201902949P-A (SG)
Title: Pharmaceutical compositions and methods of treating cardiovascular diseases
Inventor: WANG JIN
IPC: A61K47/00
Filed: 2018-05-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo Holosmomimionom oimIE (10) International Publication Number WO 2018/208723 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 45/00 (2006.01) A61K 31/00 (2006.01) A61K 47/00 (2006.01) A61K 38/00 (2006.01) A61P 9/00 (2006.01) (21) International Application Number: PCT/US2018/031505 (22) International Filing Date: 08 May 2018 (08.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/503,902 09 May 2017 (09.05.2017) US 62/652,812 04 April 2018 (04.04.2018) US (71) Applicant: CARDIX THERAPEUTICS LLC [US/US]; 8351 Gold Coast Drive, Unit 5, San Diego, CA 92126 (US). (72) Inventors: WANG, Jin, Jean; 8351 Gold Coast Drive, San Diego, CA 92126 (US). YAKATAN, Gerald, J.; 13813 Boquita Drive, Del Mar, CA 92014 (US). LIN, Ting, N.; 999 Cao Ling Road, Building 8, Lakexangdu, Suite 2, Room 304, Bengbu, Anhui (CN). GAO, Jing, H.; 999 Cao Ling Road, Building 8, Lakexangdu, Suite 2, Room 304, Beng- bu, Anhui (CN). (74) Agent: YU, Lin et al.; Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 1-1 • N N QC O N 00 O 1-1 N C (54) Title: PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES (57) : Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine Hi-receptor agonist, a histamine H2 -receptor agonist, a histamine H 3 -receptor antagonist, or a [3 2 -adrenoreceptor agonist. Also provided herein is a method of treating, preventing, or ameliorating a cardiovascular disease in a subject, comprising administering to the subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine Hi- receptor agonist, a histamine H 2 -receptor agonist, a histamine H 3 -receptor antagonist, or a [32-adrenoreceptor agonist.