baber/WOPTO huggingface dataset:
Patent PT-1131424-E (PT)
Title: Mutation of the parkin gene, compositions, methods and uses
Inventor: DENEFLE PATRICE
IPC: A61K38/17
Filed: 1999-11-18
Abstract: New nucleic acid (I) encodes human parkin protein and includes at least one of the following genetic alterations: (a) deletion of one or more exons, optionally in combination; (b) multiplication of exons; (c) point mutations; or (d) deletion or insertion of one or more contiguous base pairs. Independent claims are also included for the following: (1) a polypeptide (II) encoded by (I); (2) an antibody (Ab) specific for (II); (3) a nucleic acid probe (Ia) that hybridizes specifically with (I); (4) primer pairs for amplifying all or part of (I); (5) a method for identifying genetic alterations in the parkin gene by amplifying at least part of the gene and detecting the specified alterations; (6) a method for diagnosing susceptibility to parkinsonism by detecting a specified alteration in the parkin gene; (7) a vector containing (I); (8) a cell containing the vector of (8); and (9) a non-human animal containing (I) in its cells. ACTIVITY : None given. MECHANISM OF ACTION : None given. No biological data given.
Patent FR-83-F (FR)
Abstract: APPAREIL COWPER, EN PARTICULIER POUR HAUTS-FOURNEAUX, COMPORTANT UN GARNISSAGE REFRACTAIRE ET UNE ENVELOPPE QUI EST PAR EXEMPLE CONSTITUEE PAR DES VIROLES MUTUELLEMENT SOUDEES ET REALISEE, AU MOINS EN PARTIE, SOUS LA FORME D'UNE DOUBLE ENVELOPPE CREUSE, LA DOUBLE ENVELOPPE ETANT FORMEE EN APPLIQUANT UNE SECONDE ENVELOPPE EXTERIEURE SUR L'ENVELOPPE ENTOURANT LE GARNISSAGE REFRACTAIRE ET EN REMPLISSANT LA FENTE COMPRISE ENTRE LES DEUX ENVELOPPES AVEC AU MOINS UNE MATIERE SECHE ET FLUIDE, PAR EXEMPLE A BASE DE SIC ET DE GRAPHITE. POUR EMPECHER UNE SURPRESSION DANS LA FENTE INTERMEDIAIRE 6 DE LA DOUBLE ENVELOPPE 1, 5 ET UNE ATTAQUE DE LA NOUVELLE ENVELOPPE 5 PAR LE CONDENSAT, LA FENTE ENTRE LES DEUX ENVELOPPES DE TOLE EST RACCORDEE PAR UN SYSTEME DE CONDUITE TUBULAIRE24 A L'ESPACE SITUE EN DESSOUS DE LA CHAMBRE DE RECUPERATION 2.
Patent SG-29990-G (SG)
Title: Safety lock,object,especially a piece of luggage,and an installation for applying it
IPC: E05C5/00
Filed: 1990-04-19
Abstract: A closing device includes a keeper provided with a retaining element for retaining a bolt in the keeper in a closed position of the device. The retaining element is mounted to be pivotable about and to be axially movable on a rod provided in the keeper and is resiliently biased to both axially slide on and pivot about the rod in such manner that, in an active position, the retaining element projects into an extension of an opening into which the bolt is capable of entering so as to close the device, and it is brought to a retracted position by axially sliding along the rod while being automatically returned to its active position from its retracted position as soon as the bolt is extracted from the keeper under the effect of the resilient force exerted by a spring.
Patent SG-65692-G (SG)
Title: Isolation of proteins of htlv-iii,serological detection of antibodies to htlv-iii in sera of patients with aids and pre-aids conditions,and detection of htlv-iii infection by immuno-assays using htlv-iii and its proteins
IPC: G01N33/569
Filed: 1992-06-30
Abstract: Production of core antigens of the virus HTLV-III and their use in detection of antibodies in sera of AIDS and pre-AIDS patients, and to biochemical and immunological analysis of antigens associated with the virus HTLV-III. The utilization of p24 and p41 core antigens enables a greater specificity of detection. It is shown that antigens associated with the infection of human cells by the virus are specifically recognized by antibodies from AIDS patients. Specifically, HTLV-III isolated from AIDS patients and transformed by occultivation with an HT cell line is specifically detected by antibodies from human sera taken from AIDS patients. The p24 and p41 antigens are used to monitor the precense of HTLV-III in cultured cells and cell-free culture fluids, where virus infection is suspected, and also to monitor antibodies in human sera. The method of detection of antibodies preferred is a radioimmunoassay (RIA), ELISA (an enzyme-linked immuno-sorbent assay) or indirect immunofluorescene assay.
Patent IE-33724-L (IE)
Title: Ó-amylase detergent compositions
IPC: C11D3/386
Filed: 1970-02-16
Abstract: 1275301 Detergent granules containing α- amylase PROCTER & GAMBLE Ltd 19 Feb 1970 [19 Feb 1969] 9008/69 Heading C5D A granular detergent composition consists essentially of, by weight:-(A) 40-98% of a mixture of an organic detergent and an alkaline builder salt, in a ratio of organic detergent to alkaline builder of 1 : 30 to 4 : 1; (B) 0-50% of a perborate bleaching agent; (C) 0À0005 to 3% of α-amylase (calculated on the basis of pure α- amylase), and (D) an α-amylase-stabilizing amount of starch (in addition to any starch which is an inert carrier for the α-amylase) or modified starch in a weight ratio of starch to pure α-amylase of 1 : 1 to 5000 : 1. The starch should not exceed 10% of the composition and may be corn, potato, wheat, tapioca, rice or maize starch. The modified starch is natural starch oxidized by heating or hydrolysed with an acid or enzyme e.g. water-soluble starches and dextrins. The α-amylase may be obtained from animal, fungal, bacterial (e.g. Bacillus subtilis) and cereal grain sources. The organic detergents may be anionic (including soaps), non-ionic (including tertiary amine oxides, phosphine oxides and long chain sulphoxides), ampholytic or zwitherionic, and mixtures thereof. The alkaline builder salts may be (a) inorganic (e.g. carbonates, phosphates, polyphosphates and silicates) or (b) inorganic (e.g. alkali metal, NH 4 or substituted NH 4 polyphosphonates, polyacetates and polycarbonylates). The perborate bleach may be sodium perborate tetrahydrate and/or monohydrate. Conventional detergent auxiliaries may be present. The composition may comprise 80-98% of detergent granules containing organic detergent and builder salt  perborate bleach and 2 to 10% of enzyme carrier granules containing the α- amylase and the starch. It is preferred to form the enzyme granules by spraying a slurry of α- amylase and starch on to incompletely hydrated sodium tripolyphosphate, and mixing the resultant enzyme granules with conventionally prepared granules containing the other ingredients of the composition.
[GB1275301A]
Patent IE-800312-L (IE)
Title: Lithographic ink containing oxidatively curable reactive¹diluent
IPC: C09D11/10
Filed: 1980-02-19
Abstract: Disclosed are inks containing compounds of the formula: <IMAGE> where -R1 is -H or -CH3 -R2 is an aliphatic, preferably linear hydrocarbyl, radical having 11-23 carbon atoms and containing at least one olefinic double bond, or mixtures thereof, -R2 being free of terminal double bonds, and -X- is either (a) -OR3O- in which R3 is an aliphatic or cycloaliphatic hydrocarbon residue containing from 2 to 10 carbon atoms, or (b) -O(CH2CHR4O)n- where R4 is -H or -CH3 and n is an integer of from 2-10, or mixtures thereof. Preferably, -X- is -OR3O- wherein R3 is -CH2CH2- or <IMAGE> -R1 is -CH3, and -R2 is a mixture of hydrocarbyl moieties derived from drying oils and is at least in part polyunsaturated, and more preferably, predominantly so. The products are oxidatively curable reactive diluents of exceptionally low viscosity and low volatility which are useful for the preparation of high solids lithographic inks to reduce atmospheric pollution caused by volatile non-reactive solvents. In addition to compounds of the given formula, other esters of drying oil fatty acids with various addition-polymerizable olefinically unsaturated hydroxyl-containing compounds are disclosed. Another way of describing the preferred reactive diluents of the invention is to define them as the mixed esters of a polyol with (1) mixed natural drying oil fatty acids and (2) an alpha , beta -ethylenically unsaturated acid.
[US4255196A]
Patent IE-37368-L (IE)
Title: Bridgehead-heterocyclic compounds
IPC: A61K31/435
Filed: 1973-03-05
Abstract: 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5- dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative. (From US3856798 A) [FR2181794A1]
Patent IE-36441-L (IE)
Title: New pyridylpiperazines
IPC: C07D401/04
Filed: 1972-05-11
Abstract: 1345449 Piperazine derivatives SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 4 May 1972 [14 May 1971] 14877/71 Heading C2C Novel piperazine derivatives of the formula and acid addition salts thereof, wherein Het is pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl and the amino radical is in a para position to the carbonyl group; R 1 is H or C 1-4 alkyl; and R 2 is H, C 1-4 alkyl or C 1-4 alkoxy are prepared by reacting mixed anhydrides of the formula with the appropriate 1-(2-amino (or alkylamino) ethyl)-4-(R 2 -pyridyl) piperazines and hydrolysing the resulting acetamides of the formula Pharmaceutical compositions, suitable for oral, rectal or parenteral administration, contain the above novel compounds or acid addition salts thereof in admixture or conjunction with pharmaceutically suitable carriers. The compounds possess broncholytic, antianaphylactic and central nervous system depressant properties. (From GB1345449 A) [FR2137689A1]
Patent IE-860905-L (IE)
Title: Water-dispersible synthetic fiber
IPC: D02G/
Filed: 1986-04-08
Abstract: Water-dispersible polyester fiber of cruciform cross-section to promote dispersibility, and so better uniformity, more opacity, good permeability and an attractive flannel-like hand to the resulting wet-laid fabrics.
Patent FI-830937-L (FI)
Inventor: JANSMA WYTZE
IPC: C08B30/04
Filed: 1983-03-21
Abstract: In a process utilising a battery of hydrocyclones for separating wheat starch and gluten contained in an aqueous wheat flour slurry, the slurry is supplied to a first section of the hydrocyclone battery, in which a gluten fraction is removed as overflow, and the starch-rich fraction from such first battery section is first treated to reduce its pentosan content and is then treated in a second section of the hydrocyclone battery which delivers a concentrated starch fraction as underflow.
Patent FI-850762-L (FI)
Inventor: SORENSEN JORGEN B
IPC: F16L5/02
Filed: 1985-02-25
Abstract: A pipe (3) extending through a floor (9) or a wall in a building structure is insulated from the floor or wall by first forming an opening (10) around the pipe, after which a lead-through sleeve (1,2) is placed on the pipe and, if and as required, pushed into place in the opening (10). Then the space between the lead-through sleeve (1,2) and the wall of the opening (10) is filled with a suitable settable mass (11), such as cement mortar, the mass (11) being prevented, if necessary, from flowing out below by a rosette or the like (not shown). The lead-through sleeve (1,2) consists of an inner mantle or lining (1) of heat-insulating and elastically resilient material, such as foam rubber or plastic, and an outer mantle or shell (2) of e.g. thin sheet material. The inner mantle (1) and the outer mantle (2) are so dimensioned relative to each other and to the pipe (3) that the certain mantle (2) maintains the inner mantle (1) under a certain degree of elastic compression, sufficient to hold the lead-through sleeve (1, 2) on the pipe (3) by friction, but insufficient to prevent the lead-through sleeve (1, 2) being moved along the pipe (3), such as by pushing it by hand. To make it possible to install the lead-through sleeve (1,2) on pipes already installed, i.e. with inaccessible ends, it can have at least one longitudinal slit or slot, so that it may be opened lengthwise and placed sideways on the pipe, after which is pressed together around the pipe and held on it by means of locking means (14), which may be adjustable as shown in the form of straps cooperating with one of a number of slots (23). The invention makes it possible to insulate, especially heat-insulate, existing pipe installations using few and simple operations.
Patent IE-45062-L (IE)
Title: Supplying gaseous fuel to an engine
IPC: F02M21/04
Filed: 1977-05-23
Abstract: The invention relates to an installation for supplying gaseous fuels such as LPG and natural gas to a combustion engine, said installation being provided with a membrane provided in a housing and being coupled to the valve stem of a gas control valve, the space of said membrane at the one side thereof being connected with a venturi, in which the gaseous fuel is mixed with air drawn into said venturi by the depression created in the engine when running, said connection being such that in said space prevails the depression created during the running of said motor, the other side of the membrane being in connection with the air inlet of the venturi, three springs being provided at said one side of the membrane, said springs being dimensioned and arranged in such a way that the first of said springs is compressed when a small depression, e.g. a pressure of 20 cm water column, occurs at said one side of the membrane, the second spring being compressed as the depression in said space increases, e.g. to a pressure of 15 mm Hg, the third spring being compressed when the engine decelerates, a fourth spring being provided at the other side of the membrane which trys to move the gas control valve in a direction towards its open position.
[US4152121A]
Patent IE-821127-L (IE)
Title: Injectable chondroitin polysulfate
IPC: A61K31/715
Filed: 1982-05-11
Abstract: The invention relates to a process for the preparation of an injectable chondroitin polysulfate, which is characterized in that A crude chondroitin polysulfate is depolymerized oxidatively, B the depolymerized chondroitin polysulfate is bleached, if necessary, with peracetic acid, C the product obtained after A or B is subjected once or twice to precipitation with methanol and/or ultrafiltration for fractionation with respect to molecular weight, D the product obtained after C is demineralized, if necessary, with cation exchangers, and E the product obtained after C or D is decolorized, if necessary, with active charcoal. The invention furthermore relates to a chondroitin polysulfate which can be prepared by the above process. The invention also relates to a chondroitin polysulfate with an acute toxicity (LD50), on intravenous administration, of >3,500 mg/kg in NMRI mice, of >3,000 mg/kg in Wistar rats, of >1,000 mg/kg in cats and of >1,000 mg/kg in dogs. Finally, the invention relates to a pharmaceutical composition for human and veterinary medicine, characterized in that it contains a chondroitin polysulfate which can be prepared according to the above process of a chondroitin polysulfate with the above characteristics.
[US4524066A]
Patent IE-34646-L (IE)
Title: Beneficiation of ilmenite
IPC: C22B34/12
Filed: 1970-10-01
Abstract: 1,262,401. Benificiation of ilmenite; iron oxide. BENILITE CORP. 14 April, 1970 [15 Oct., 1969], No. 17691/70. Headings C1A and C1N. A titaniferous ore or slag, e.g. ilmenite, ilmenite magnetite, ilmenite-hematite, titaniferous magnetite, and titaniferous hematite, is benificiated 'by leaching it in a digester with hydrochloric acid leach liquor, the leaching liquor being heated during this process by feeding into the digester a vapour mixture formed by distilling an azeotropic mixture of HCl -and -water, by which means the HCl content of the leach liquor is simultaneously replenished. The leaching may be .conducted at a pressure of 20-50 p.s.i.g. and a temperature of 108 to 145 C., and the HCl content of the leach liquor may be recovered and reused in the process either as leach liquor or as the source of the vapour mixture. The preferred HCl concentration of the leach liquor is 20% by wt., and the leaching may be performed in two counter current stages. Depending on the ferrie/ferrous content of the ore, it may first be subjected to a reducing step, e.g. with coke at 815 to 1090 C. The iron content of the used leach liquor may be obtained as the oxide by hydrolysis of the chloride at high temperatures, e.g. 260-500 C., by direct contact with combustion gases. This simultaneously regenerates the HCl leach liquor.
[GB1262401A]
Patent IE-37591-L (IE)
Title: Ship's hull
IPC: B63B1/20
Filed: 1973-07-27
Abstract: A modification of a trimaran hull for improving the stability thereof in which the middle hull extends to a depth below that of the side hulls, the lower part of the middle hull having a rounded bow, and being considerably shorter in length than the side hulls and terminating forwards of the aft end of the side hulls.
[US3885514A]
Patent IE-38164-L (IE)
Title: Tyres, internal inflatable structure
IPC: B29D30/04
Filed: 1973-07-30
Abstract: A pneumatic tire with both a sealing action and an anti-burst action is disclosed. The tire has an inflatable structure made of an elastic foam material having prevailingly closed cells in the form of an annular band below the tread band of the casing with a width at least equal to the width of the tread band and means preventing the flow of tire air out of the area between the outer surface of the annular band and the casing inner surface corresponding thereto. The tire can be radial if desired.
[US3921689A]
Patent IE-44101-L (IE)
Title: Acetylenic tertiary glycols, their preparation and the¹production of derivatives thereof
IPC: C09K23/38
Filed: 1976-06-24
Abstract: 1520855 Textile lubricants ANIC SpA 22 June 1976 [24 June 1975] 25977/76 Heading C5F [Also in Division C2] Novel surface-active compounds which may be used as anti-static lubricants in the spinning of filaments, comprise (a) polyethoxy derivatives of unsaturated diols of the formula where R is H or an olefinically unsaturated aliphatic radical, e.g. -CH 2 -CH= C(CH 3 ) 2 .
[GB1520855A]
Patent IE-811425-L (IE)
Title: Printers ribbon cartridge
IPC: B41J33/00
Filed: 1981-06-26
Abstract: Connected to the take-up spool (26) of the ribbon cartridge (10) is a disc member (28) supporting a pair of flexible arms (32) with outwardly oriented pointed ends (34). Ends (34) engage ratchet teeth (44) formed on the internal surface of a cylinder (42) forming part of, or attached to, the ribbon cartridge (10). As disc (28) and arms (32) are rotated by the ribbon feed mechanism, arms (32) will flex and permit a rotation of disc (28) and take-up spool (26) with a minimal drag force. Upon reversal, the ends (34) of arms (32) engage ratchet teeth (44) and arms (32) become compression columns resisting the rotation of disc (28) and spool (26). Ends (34) of arms (32) are positioned such that they are one-half tooth out of phase to ensure that one tooth is always in engagement with the end (34) of one of the two arms (32).
Patent IE-781616-L (IE)
Title: Purified heparin
IPC: A61P7/02
Filed: 1978-08-08
Abstract: This invention relates to oxalate-free preparations of heparin, particularly in the form of calcium salts of heparin, which can be used for the preparation of injectable solutions of heparin which have long storage life. The invention is also directed to a process for freeing heparin from its oxalate content, such as by fractional precipitations by alcohol in the presence of adjusted amounts of mineral salt, until the heparin precipitated contains less than about 70 ppm of oxalate but may contain less than about 30 ppm, preferably even less than 20 ppm.
[US4652555A]
Patent IE-36939-L (IE)
Title: Imidazole derivatives of rifamycin
IPC: C07D233/20
Filed: 1972-11-30
Abstract: 1388880 3-Imidazole derivatives of rifamycin SV GRUPPO LEPETIT SpA 28 Dec 1972 [19 Jan 1972] 59832/72 Heading C2C Novel 3-imidazole derivatives of rifamycin SV having the general Formula (I) and the corresponding 25-desacetyl and 16, 17, 18, 19, 28, 29-hexahydro derivatives, wherein R is hydrogen, C 1-6 alkyl, phenyl or phenyl- C 1-6 alkyl; and R 1 and R 2 together represent a carbocyclic residue forming with the double bond of the adjacent imidazol moiety a benzene ring; a mono- or poly-substituted benzene ring wherein the substituents are selected from C 1-6 alkyl, C 1-6 alkoxy, halo, carbalkoxy, carboxy, sulpho, sulphamoyl, nitro, trifluoromethyl, carbamyl, mono- and di-C 1-6 alkylcarbamyl and methylenedioxy; or a substituted or unsubstituted polynuclear aromatic radical composed of 2 or 3 fused rings each of 5-6 carbon atoms, are prepared by reacting 3-formylrifamycin SV or a 25-desacetyl or 16, 17, 18, 19, 28, 29-hexahydro derivative thereof, with an orthodiamine of formula wherein R, R 1 and R 2 are as defined above, and then oxidizing the product with air, a cupric salt, mercuric oxide, manganese dioxide, isoamyl nitrite, potassium ferricyanide or lead tetraacetate, and if the rifamycin moiety in the obtained compound is in the quinone form, reducing it to the corresponding hydroquinone with aqueous ascorbic acid. The compounds (I) have antibacterial, antiviral and anti-cancer activity and may be admixed with a pharmaceutical carrier to provide pharmaceutical compositions having such activity.
[GB1388880A]
Patent IE-38504-L (IE)
Title: Sheathed electric cable
IPC: H01B7/00
Filed: 1973-11-09
Abstract: An electric cable having one or more insulated cores with an external semi-conductive screen surrounded by a corrugated metal sheath and having a tube of soft, semi-conductive material intermediate the core and the sheath with the corrugations of the sheath embedded therein to both prevent slippage of the core with respect to the sheath and conductively interconnect the sheath and the screen. The tube may be a wound tape of semi-conductive crepe paper or such a tape surrounded by glass cloth having intercalated metal wires.[US3843830A]
Patent IE-802356-L (IE)
Title: Ion implantation
IPC: H01L21/00
Filed: 1980-11-12
Abstract: An ion implantation process uses exclusively photoresist masks to cover a substrate except in the regions to be implanted with ions. The photoresist masks are removed after each ion implantation by plasma etching.
[US4341571A]
Patent IE-792362-L (IE)
Title: Moulded wafers
IPC: A21C15/02
Filed: 1979-12-07
Abstract: Moulded wafer products are prepared by a novel process in novel apparatus from dough of high sugar content (25-60% w/w based on the farinaceous dough ingredient) by a two-stage process comprising initial baking of a light-textured water material (e.g. 2-3 mm thick), introducing the wafer while still hot (e.g. above 160-195 DEG C), into a cooling and compressing mould (3,4,5) of the apparatus, and compressing the wafer to reduce its wall thickness, e.g. by about 15-50%.
Patent IE-852852-L (IE)
Title: Benzothiazine dioxide salt.
IPC: C07D417/12
Filed: 1985-11-15
Abstract: A novel crystalline form of the monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide has been prepared. This novel crystalline form is designated as polymorph I and is useful in therapy as a nonsteroidal antiarthritic agent. Methods for preparing this polymorph from readily available materials are provided.