baber/WOPTO huggingface dataset:
Patent EP-2368991-B1 (EP)
Inventor: TANHA JAMSHID
IPC: C12N15/10
Filed: 2006-03-24
Granted: 2016-02-17
Abstract: Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human V H s and V L s, are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human V H s or V L s are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human V H s and V L s are also identified. The V H s and V L s identified many be used to create further libraries for identifying additional polypeptides. Further, the V H s and V L s may be subjected to DNA shuffling to select for improved biophysical properties.
Patent EP-2326004-B1 (EP)
Inventor: SAINT ELLIER PIERRE
IPC: H03K5/135
Filed: 2010-11-10
Granted: 2012-03-14
Abstract: The circuit has a NOX logic gate (104) for outputting the synchronization signal (105) according to NOX logic function between clock signals (101, 102). A D flip-flop type logic circuit (106) receives the signal (105) and a signal (108) from a frequency detector (107), and produces a control signal (109) at the destination of a clock switch (103) piloting the switching between the signals (101, 102), such that a clock signal (110) is equal to the signals (101, 102) when the frequency of the signal (101) is equal to low and high clock frequencies (F1, F2) of the signal (101), respectively.
Patent EP-2246603-B1 (EP)
Inventor: COURBIS HERVE
IPC: F16L13/02
Filed: 2010-03-26
Granted: 2011-08-03
Abstract: The device has a sealing and insulating structure including a primary component realized in form of a cylinder (B) made of silicone material, and a secondary component made of polyurethane to partially surround the primary component. The secondary component is in form of a sleeve (C) having length greater than that of the primary component defined by the cylinder. The structure is positioned around isolation tubes that are opened for permitting insertion of the structure and closed due to deformation of the cylinder parts, which are not covered by the sleeve.
Patent EP-2397083-B1 (EP)
Inventor: SIXTO ROBERT JR
IPC: A61B17/17
Filed: 2008-10-30
Granted: 2014-05-07
Abstract: A tool for shaping a bone plate comprises a handle having a first end, a second end, and a longitudinal axis, and an end effector coupled to the first end of the handle. The end effector includes a retaining arm that is provided with a bore having a bore axis extending transverse relative to the longitudinal axis, and a first fulcrum positioned on a first side of the longitudinal axis and longitudinally offset from the bore axis and contained within a plane defined by the longitudinal axis and the bore axis.
Patent EP-2471965-B1 (EP)
Inventor: WANG YUTING
IPC: C22C1/02
Filed: 2011-12-22
Granted: 2013-05-01
Abstract: An object of the present invention is to provide a Ni-based superalloy, especially for a conventional casting, having a good balance among high temperature strength, corrosion resistance and oxidation resistance, as compared to a conventional material. The Ni-based superalloy comprises Cr, Co, Al, Ti, Ta, W, Mo, Nb, C, B, and inevitable impurities, the balance being Ni, the Ni-based superalloy having a superalloy composition comprising, by mass, 13.1 to 16.0% Cr, 11.1 to 20.0% Co, 2.30 to 3.30% Al, 4.55 to 6.00% Ti, 2.50 to 3.50% Ta, 4.00 to 5.50% W, 0.10 to 1.20% Mo, 0.10 to 0.90% Nb, 0.05 to 0.20% C, and 0.005 to 0.02% B.
Patent EP-2940034-B1 (EP)
Inventor: KELLEHER THOMAS J
IPC: C07K7/00
Filed: 2001-01-18
Granted: 2020-05-06
Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of  Streptomyces roseosporus.  The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Patent EP-0020520-B1 (EP)
IPC: E04B1/38
Filed: 1980-04-22
Granted: 1985-01-09
Abstract: Un ensemble d'ancrage ameliore (10) sert a retenir un organe d'attache allonge dans une ouverture definie par une portion de paroi ayant au moins un cote cache. De tels dispositifs comprennent de maniere caracteristique au moins deux pattes allongees (11), des moyens (14) de connexion d'une paire de portions extremes adjacentes (13) des pattes (11), un membre d'ancrage avec des ouvertures (18) accouplee aux pattes (11) sur les portions extremes opposees (16) et un collier (22) fixe aux pattes (11) pour prendre en sandwich la portion de parois entre le collier (22) et l'organe d'ancrage (18). L'amelioration consiste a pourvoir chacune des pattes (11) de goujons d'accouplement respectif (17) alignes suivant leur dimension transversale la plus grande pour engager des brides sensiblement longitudinales (20) de l'organe d'ancrage (18) de chaque cote de maniere a attacher les pattes (18) transversalement par rapport a la petite dimension de l'organe d'ancrage (18).
Patent EP-0014501-B1 (EP)
IPC: A47L13/16
Filed: 1980-01-24
Granted: 1984-03-07
Abstract: Disposable devices useful for cleaning and wiping hard surfaces. The devices have a core interposed between and laminated to two outer layers. The core is preferably an absorbent paper web, while the outer layers are preferably apertured nonwoven fabrics having defined properties. The wiping device is strong, absorbent, and will retain sufficient water after manual wringing to clean soiled surfaces, and will leave the cleaned surface essentially dry.
Patent EP-0021500-B1 (EP)
IPC: C09C1/36
Filed: 1980-06-10
Granted: 1983-10-12
Abstract: This invention relates to a process for coating microscopic and macroscopic substrates.The process comprises essentially three steps, the first step consisting in coating a substrate with a first layer of a liquid medium containing a polyhydroxylated polymer, preferably, polyvinyl alcohol and a transition metal, preferably copper capable of forming a complex or already complexed, a second step consisting in applying on the first layer a polymerizable material capable of being grafted on the first layer, preferably a material containing acrylic or methacrylic unsaturations, and a third step consisting in causing the polymerization with grafting of the polymerizable material onto said first layer.
Patent EP-0024144-B1 (EP)
IPC: F42C19/08
Filed: 1980-07-30
Granted: 1984-06-06
Abstract: The firearm (10) fire projectiles (22 22A) by ignition of a separate propellant cartridge (24) disposed therebehind. The firearm comprises a body including a receiver (12), a barrel (14) connected to the receiver, and a firing chamber (17) communicating with a bore of the barrel. A bolt (20) is slidably mounted in the body and includes two pockets (26,28) for receiving the projectile (22) and the cartridge (24) and for advancing them to an armed position within the firing chamber (17). 
<??>In order to increase the safety of the firearm in use and of the manufacture and storage of the cartridge the primer charge (66) for igniting the cartridge (24) is disposed within a metal casing (48) within the projectile (22 22A). A portion (32) of the bolt (20) is arranged to ignite the primer charge (66) when the projectile reaches the armed position.
Patent EP-0026621-B1 (EP)
IPC: G01B7/28
Filed: 1980-09-19
Granted: 1984-10-17
Abstract: A device (10) which detects irregularities in the contour of sidewalls of a tire (T) includes transducer probes (29, 30) which are positioned by control systems (31, 40, 45) adjacent the sidewalls of the tire (T) to be tested. As the tire (T) is rotated the output signals of the transducer probes (29, 30), which are proportional to sidewall contour, are fed to a signal processing circuit (60) which provides an output signal indicative of an irregularity in the contour of a sidewall when an irregularity of a predetermined extent exists for a predetermined time period.
Patent EP-0028509-B1 (EP)
IPC: G01B11/06
Filed: 1980-10-30
Granted: 1984-06-27
Abstract: A distance indicating device comprises a probe having therein a light source and light sensitive element to receive light reflected from the surroundings of the probe. A reference point is movable relative to the probe. The light sensitive element gives rise to an electric signal. A first storage means stores a signal representing the maximum reflected light returned to the light sensitive element. A second storage means stores a signal representing the light returned to the light sensitive element representing the minimum reflected light. A selection means selects a signal level between the maximum and minimum stored signals' and a measuring element measures the distance between the reference point and a further reference point, associated with the probe, when the signal level reaches the selected signal level.
Patent EP-0029792-B1 (EP)
IPC: B05D1/26
Filed: 1980-11-26
Granted: 1985-03-13
Abstract: 1. A device for obtaining the coating on a continuous basis of the external surface of a section (2) with a substantially constant cross section, in particular a closed one such as a pipe, by means of a liquid product, comprising means (3) for causing the section to advance along a longitudinal feeding motion through a coating tank (9) comprising an inlet opening provided with a leak proof seal (14) and an outlet opening provided with a semi-leak proof seal (18) capable of being traversed by the section, characterized in that the semi-leak proof seal (18) is, on the internal side of the coating tank, entirely immersed in the liquid product and that it is formed by a hollow tubing (19) of an expanding material and filled by a fluid under with a density close to that of the said liquid product.
Patent EP-0022102-B1 (EP)
IPC: F16B41/00
Filed: 1980-06-10
Granted: 1983-07-13
Abstract: A locking device for locking a pivotable or rotatable shaft against rotation, e.g. a shaft (1) for activating the supporting legs (3) of a caravan (6), comprises a housing (10) in which the shaft (1) together with an associated anchoring means (1a) can be inserted. One side surface (10a) of the housing (10) is provided with a non-round hole (12) through which a lock cylinder (15) can be inserted, so that a rotatable anchoring latch (16) connected to the cylinder plug and extending at right angles to the shaft (1) can co-act with anchoring means (1a) of the shaft. In the locking position, the housing is held on the shaft which, at the same time, is held latched against rotation.
Patent EP-0033916-B1 (EP)
IPC: F25D25/02
Filed: 1981-01-30
Granted: 1983-07-13
Abstract: 1. Refrigerator with a withdrawable stock carrier (10a), which is adjustable in height and rests on withdrawal rails (9) of a slide guide, wherein the carriers for the guide elements (8), which are stationary in operation, engage in oppositely disposed grooves (4), which are arranged in the side walls of the refrigerator and extend in sliding direction, characterized thereby, that a common, vertically standing and removable abutment (10) is associated at the door side of the refrigerator with the grooves (4) provided in the adjustment range of the stock carrier.
Patent EP-0054362-B1 (EP)
IPC: G01N29/02
Filed: 1981-11-20
Granted: 1985-07-03
Abstract: An apparatus for separating heavy solids from an effluent, for example wool scouring effluent, comprising a tank having a solids discharge outlet at its base and an ultra-sonic sensor located at a predetermined distance from this outlet. Means responsive to the output of the sensor, for example a solonoid controled valve, are provided for opening the discharge outlet when the solids concentration exceeds the preset limit. Preferably, a secondary settlement tank immediately below and directly communicating with the main tank is provided and the discharge outlet, controlled by a suitable valve, is at the base of the secondary tank. The secondary tank has a zone offset from the main solid flow in which the sensor may be located in order that large aggregates of solids do not lead to spurious operation of the sensor.
Patent EP-0058925-B1 (EP)
IPC: E02D29/02
Filed: 1982-02-17
Granted: 1984-04-25
Abstract: Structural components for constructing a retaining wall, a noise barrier or similar structure are made up of a pair of horizontally extending generally parallel runner elements and connecting elements joining the runner elements together. The downwardly facing lower surface of each runner element has a concave curvature. The concave curvature is made up of a stepped surface which is higher at the outer side of the runner elements than at the inner side. Lines normal to the individual stepped surfaces intersect below the concave surface at a point. The structure components can be stacked one on the other to form a wall backfilled with earth or other material. Sound waves striking against the stepped surfaces are reflected into the slopes of the backfilled material between the individual components.
Patent EP-0071937-B1 (EP)
IPC: H02P3/24
Filed: 1982-08-02
Granted: 1986-07-30
Abstract: 1. Switching equipment for direct current braking of an alternating current motor (M, DM) with at least two phase windings (w, w'; w1, w2, w3), to which the driving current is conducted from an alternating current mains by way of phase conductors (R; R, S) with switch-on member (5; 5, 6) of an operating switch and a phase conductor (S; T) without switch-on member, with a single-phase braking current circuit, which is associated with the motor, connects the alternating current mains (N) and the motor each with the other and contains a first (L'R ; L'st ) and a second (L's ; L'T ) partial braking current circuit, of which the first partial current circuit leads by way of a thyristor (Th) and a rest contact (1) and the second partial current circuit leads from the phase conductor without switch-on member by way of a freewheel diode (D) and the rest contact to a connection terminal of the phase winding of the motor, wherein the rest contact is connected mechanically with the operating switch and closed after opening of the operating switch, characterised thereby, that both the braking current circuits lead to the same connection terminal and that this connection terminal is not connected directly with a phase conductor (LR , LS ).
Patent EP-0077971-B1 (EP)
IPC: C12N11/16
Filed: 1982-10-12
Granted: 1987-12-16
Abstract: The present invention is a method for the immobilization of the sucrose mutase in whole cells of Protaminobacter rubrum having sucrose mutase activity which involves contacting the cells with tannic acid, polyethylenimine, and an adduct of glutaraldhyde and an epihalohydrin/polyamine copolymer.
Patent EP-0069423-B1 (EP)
IPC: A61K9/10
Filed: 1982-06-29
Granted: 1988-04-27
Abstract: The invention relates to compositions in the form of a stable "fatty-cream" for topical application to the body which comprise a fatty base, water, at least one hydrophilic non-ionic surfactant and a topically-active therapeutic agent, the composition containing from 50 to 80% (preferably 60-70%) by weight of fatty material(s) and from 1.5 to 5% by weight of surfactant.
Patent EP-0069710-B1 (EP)
IPC: B25C5/16
Filed: 1982-06-28
Granted: 1987-05-06
Abstract: A portable rivetting machine of the type including a channel (20) for slidingly receiving a series of interconnected rivet elements (rivets, U-shaped staples and the like), a resiliently-loaded slidable pusher for pushing the series of elements towards a discharge end. The channel (20) is internally provided with more than one pair of longitudinal dividing walls (38, 40) extending up from its base wall so as to define pairs of interstices (50, 52) disposed symmetrically with respect to the centre line of the channel as well as a central interstice (54) extending along the centre line of the channel. Each pair of two interstices (50, 52) is arranged to receive the legs of a respective series of U-shaped staples (E1, E2) of a width corresponding to the distance between the interstices themselves. The central interstice (52) is arranged to receive a series of rivets (E3). The pusher (56) includes the same number of parallel blades (60, 66, 68) as the number of interstices with each blade being housed in an interstice itself. The blades are interconnected by a yoke (62, 68) above the upper edges of the dividing walls of the channel (20).
Patent EP-0088976-B1 (EP)
IPC: A47J43/044
Filed: 1983-03-07
Granted: 1985-06-05
Abstract: 1. A device for securing an electrical household appliance (16) to a supporting plate (14), comprising, on the one hand, interengaging means on a wall (24) of the appliance and a wall (20) of the supporting plate and, on the other hand, a locking mechanism for locking the appliance (16) to the supporting plate (14) when the interengaging means has become effective, characterized in that, on the one hand, the interengaging means comprise at least one foot (18) fixedly connected to one (20) of said walls and extending in parallel thereto and a seat (22) formed in the other wall (24), into which the foot (18) is pushed upon a shifting movement of the appliance (16) on the supporting plate (14) and, on the other hand, the locking mechanism comprises a stop (26) held on the supporting plate (14) transversely of the specified shifting direction so as to be movable between a locking position, in which it projects from the supporting plate and thus comes into engagement with a shoulder (28) formed on the appliance to thereby prevent any displacement of said appliance on the supporting plate, and a releasing position, in which it is flush with the supporting plate (14) to thereby allow release of the foot (18) from its seat (22).
Patent EP-0093617-B1 (EP)
IPC: H02G15/18
Filed: 1983-05-03
Granted: 1989-01-18
Abstract: This invention relates to the mechanical and environmental protection of cable joints, especially in power or other current-carrying cables. Disclosed is a recoverable sleeve which conforms closely to the cable joint, and a liner which bridges the joint and comprises a plurality of elongate elements assembled into a sheet. Flexible means is provided for holding the elements in a side-by-side arrangement and allowing the separation between the elements to vary to allow the liner to conform to the profile of the cable joint. Such flexible means may extend across the element and provide a water vapour barrier. Disclosed also is a method of protecting a cable joint utilizing the sleeve and liner. Where the cables to be jointed have metal armor, screen and/or shielding, the elements may be fabricated from metal or metal alloy and may then provide both armoring and a fault current path across the joint. Use of these more closely conforming joint case assemblies improves heat transfer and reduces the overall size of the joint.
Patent EP-0107412-B1 (EP)
IPC: F24S10/70
Filed: 1983-09-30
Granted: 1987-12-09
Abstract: A solar collector element having an inner tube through which a fluid can be passed, an outer glass tube enveloping the periphery of the inner tube and defining an evacuated space between the two tubes, and a solar selective surface coating deposited on the outer surface of the inner tube. The surface coating is deposited as three layers, an inner layer composed of a metal which exhibits high reflectivity in the infra-red spectral range, an outer layer composed of a material which behaves as a semiconductor at collector operating temperatures and an intermediate layer which is composed of a dielectric material. The materials of the respective layers are selected such that the refractive index mismatch between the inner layer and the intermediate layer is greater than it would be between the inner layer and the outer layer, in the absence of the intermediate layer, whereby the infra-red emittance of the collector element is reduced relative to that of an equivalent collector element having a two-layer selective surface coating.
Patent EP-0099281-B1 (EP)
IPC: F23C10/20
Filed: 1983-06-10
Granted: 1985-09-11
Abstract: 1. Process for the combustion in a fluidized bed of low grade fuels, especially of coal or oil shales, on a travelling grate (5) inclined upwards from the front to the rear, with blowing compartments (9a, 9b, 9c, 9d, 9e) of air any other oxidant gas arranged below the grate (5) which is fed at fore with fuel, the front area of the said grate constituting a fluidisation zone (F) and the rear part of the said grate forming at a higher level than that of the fluidized bed (12) a transport section (T) of the ashes in form of a permanent layer, characterized in that : - starting from a fixed point (15), behind the fluidization zone (F), one maintains an insufficient blowing to generate the fluidization, so that between the fluidization zone (F) and the transport section (T) an intermediate settling zone (S) takes form, where ashes deposit along a bank (14), the said bank extending through the whole length of the settling zone (S), being renewed by successive parallel sections in proportion to the displacement of the grate (S), and - the flow rate of the blowing air is distributed in the blowing compartments (9a, 9b, 9c, 9d, 9e) in such a way as to create a methodical outflow of the fuel from to the rear of the fluidized bed (12), allowing the ashes to be brought in the settling zones (S) with a view to extract them.
Patent EP-0122467-B1 (EP)
Title: Image information registering/retrieving system
IPC: G06F17/30
Filed: 1984-03-14
Granted: 1991-12-18
Abstract: An image information registering/retrieving system comprises an optical disk for registering image information and for registering retrieving data, a magnetic disk for storing the retrieving data, and a control circuit for controlling the registering and retrieving operations. When the magnetic disk loses its function and is replaced by a new one, the retrieving data on the optical disk is copied on the new magnetic disk.
Patent EP-0129128-B1 (EP)
IPC: C07D403/12
Filed: 1984-06-04
Granted: 1990-11-22
Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.