baber/WOPTO huggingface dataset:
Patent HU-E028349-T2 (HU)
Title: Ca ix-specific inhibitors
Inventor: SUPURAN CLAUDIU
IPC: A61K31/4155
Filed: 2003-11-26
Abstract: Therapeutic methods for inhibiting the growth of preneoplastic/ neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membraneimpermeant compounds, which inhibit the enzymatic activity of MN protein/ polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membraneimpermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides.; The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anticancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies.; Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.
Patent TR-200002718-T2 (TR)
Title: Mobil telefonda kapak mafsalı tertibatı.
Inventor: FROHLUND STIG
IPC: E05D11/06
Filed: 1999-03-24
Abstract: Haznesi üzerine, fizik olarak mentese ekseni üzerinde dönen, koruyucu kanada sahip hücresel telefon aygitina iliskin bir tertibattir; eksen, bir ucunda edilgen mafsal aracini ve kanadi en azindan belli bir sabit konumu isgal etmesi için müspet olarak etkileyen, bir mil ve bunun üzerinde düzenlenen kombine edilmis burma/baskilama yayindan olusan etken mafsal aracini içermektedir;yay,uçlarinda, kanadi kapali konumdan 120 C-170 C uzakta açik kullanim konumuna müspet olarak zorlama için burma yayinin ters hareketli parçalari olarak görev yapan parmaklara ve kanadi tahrip olmaktan koruyan zorlanma-dayanimi islevini elde etmek için dirsekli makara tertibat tarafindan etkilenen baskilama yüzeylerine sahiptir.
Patent TR-200002756-T2 (TR)
Inventor: DYCK LILIAN E
IPC: A61P25/28
Filed: 1999-03-25
Abstract: Novel compounds of formula (I) are described wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms; R2=H, CH3 or CH2CH3; R3=H or CH3; R4=H or CH3; R5= lower alkyl having from 1 to 5 carbon atoms; n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (CN), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.
Patent TR-200003071-T2 (TR)
Title: Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler
Inventor: LUBISCH DR WILFRIED
IPC: A61K31/4409
Filed: 1999-04-19
Abstract: Eldeki bulus, enzim önleyicilerini, özellikle sistein proteazlarini meydana getiren genel formül I'in amidlerini konu almaktadir. FORMÜL (1)
Patent TR-200003317-T2 (TR)
Inventor: NERI DARIO
IPC: A61K47/48
Filed: 1999-05-11
Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
Patent TR-200003810-T2 (TR)
Inventor: DAMRATH JOACHIM
IPC: F23D14/06
Filed: 1999-08-06
Abstract: A gas burner for cooking areas includes a lower part and an upper part. The upper part has gas repulsion ducts with gas outlet openings for gas flames. The upper part is rotatably mounted on the lower part by a compressed-air bearing configured to apply a compressed-air cushion to pneumatically lift the upper part off the lower part for allowing contactless turning of the upper part in relation to the lower part about an axis of rotation. The gas repulsion ducts are formed to drive the upper part in relation to the lower part about the axis of rotation by gas flowing through the gas repulsion ducts at positive pressure. Such a configuration makes it possible to evenly distribute the heat of the flames in the periphery of the burner and to minimize minimum gas burner output by using less flames.
Patent TR-200100779-T2 (TR)
Title: Yeni bir bileşim.
Inventor: EVENDEN JOHN
IPC: A61K31/4525
Filed: 1999-09-13
Abstract: Bir ilk bilesen (a) olarak (R)-3-N, N-disiklobutilamino-8-floro-3, 4-dihidro-2H-1-benzopiran-5-karboksamid hidrojen (2R,3R)-tartar monohidrat ve bir ikinci bilesen (b) olarak serbest baz, ya da bundan dolayi eczacilikla ilgili kabul edilebilir bir tuz ve/veya eriyik formunda olan paroksetin içeren bir bilesim ile ilgilidir, bundan dolayi bahsedilen bilesimi içeren eczacilikla ilgili formüller, kullanimi ve bahsedilen bilesimi içeren teçhizat gibi, ruhsal rahatsizliklar ve endiseyle ilgili rahatsizliklar gibi duygusal rahatsizliklarin tedavisinde bir yöntemdir.
Patent TR-200103326-T2 (TR)
Title: İsoprenoidin konsantrasyonunu değiştirmek için deoksi-D-ksiluloz fosfat biyosentetik yoluna ait genlerin kullanımı
Inventor: JOMAA HASSAN
IPC: C12Q1/68
Filed: 2000-05-20
Abstract: Mevcut bulus bakterilerin ve parazitlerin DNA dizilerinin, yani gcpE ve yfgB genlerinin virüsler, ökaryotlar ve prokaryotlarin genomuna dahil edilmeleri ve böylece isoprenoidin konsantrasyonunu degistirmeleri için kullanimi ile ilgilidir. Bulus ayrica bitkilerde bir bitki öldürücü, parazit öldürücü, antiviral ve mantar öldürücü aktivite ve insanlarda ve hayvanlarda bir antimikotik, parazit öldürücü ve antiviral aktivite gösteren bir maddenin belirlenmesi için yöntemlerle de ilgilidir.
Patent DE-602004003869-T2 (DE)
Inventor: TACCHINI FRANCO
IPC: B65B9/13
Filed: 2004-08-17
Granted: 2007-07-05
Abstract: The invention relates to a method of and to an apparatus for the overwrapping of a pallet-stacked load (C) using a tubular wrapping film (P) made of a stretchable plastic material. In a rigid main support structure (1) are provided means for upwardly feeding the film, means for cutting a section of said film and for thermowelding the lower edge thereof to form a bag, as well as means for causing the upper open edge thereof to ruffle on an adjustable widening frame (13) with a similar upward movement. The adjustable widening frame (13) consists of four angular posts, mutually linked through four tubular telescopic rods. Means are provided for widening said frame and for transversally stretching said film bag, as well as means for having said adjustable widening frame slide downwards along the load (C) arranged at a wrapping station, and means for progressively releasing said film bag onto the load, simultaneously causing the turning inside-out thereof. The four angular posts of the adjustable widening frame comprise guiding means which, together with said four telescopic rods, guide said bag during its inside-out movement and brake it during the release thereof onto the load. Said welding means are associated with means cooling the finished welding. <IMAGE>
Patent DE-602004007437-T2 (DE)
Inventor: AX LARS
IPC: F41A1/10
Filed: 2004-06-02
Granted: 2008-03-20
Abstract: The invention relates to an arrangement for a weapon comprising a countermass (6) for reducing the pressure around the weapon. The countermass (6) is enclosed in a countermass container (5) with an openable cover (7) provided with break indications. The invention aims to bring about a symmetrical opening operation with favourable recoil in a better way than in previous constructions. This is achieved by the introduction of a guiding folding support (8) arranged adjacent to the openable cover (7) on the inside of the cover relative to the countermass container (5). <IMAGE>
Patent DE-602004007441-T2 (DE)
Inventor: ROSENBERG MEIR
IPC: A61M37/00
Filed: 2004-09-03
Granted: 2008-04-30
Abstract: A valve (10) that is adapted to control the flow rate of fluid flow from an implantable pump or other fluid delivery device is provided. In general, the valve includes a multi-lumen member (12) that is adapted to receive fluid-flow therethrough, and a restrictor member (14) that is coupled to the multi-lumen member such that the restrictor member is effective to selectively restrict at least a portion of one or more lumens in the multi-lumen member to thereby adjust the flow rate of fluid flowing through the multi-lumen member. The valve can be built into an implantable drug pump to control fluid flow exiting the pump, or alternatively the valve can disposed within a catheter or otherwise coupled to an outlet port in an implantable drug pump to control the flow rate of fluid exiting the drug pump. <IMAGE>
Patent DE-602004012194-T2 (DE)
Inventor: NOMA TAKAYUKI
IPC: G01C25/00
Filed: 2004-05-26
Granted: 2009-03-05
Abstract: The field has two sets of rough alignment reference marks (112,122) for wide-angle and zooming. Two sets of precise alignment reference marks (114,124) are provided in the field for wide-angle and zooming. The rough and precise alignment reference marks (122,124) are arranged within a zooming area (120). The rough and precise alignment reference marks (112,114) are arranged within a wide-angle area (110). An independent claim is also included for a method of photographing with a camera for photographing a three-dimensional field for calibration.
Patent DE-602005006017-T2 (DE)
Inventor: DURAND CLAUDE
IPC: B31B50/48
Filed: 2005-11-18
Granted: 2009-05-14
Abstract: The invention concerns a method for adjusting height of a crate or box made of flexible material, having a base and at least four side walls by folding. After the base has been placed in a generally horizontal, a horizontal crease is produced on each side wall, parallel to the base and at a height substantially equal to a top of a stack of objects. At least one oblique crease is produced in each corner of the crate, with one end located at the intersection between two horizontal creases and the other end located on an upper ridge of one side wall. The upper part of each side wall is folded towards the center of the crate, at an angle substantially equal to 90°. The various flaps are folded on one another, being separated by oblique creases, bringing the upper part of side walls in a substantially horizontal plane.
Patent DE-69304703-T3 (DE)
Inventor: SZADKOWSKI STANISLAV
IPC: B22D11/10
Filed: 1993-05-27
Granted: 2002-11-21
Abstract: PCT No. PCT/BE93/00029 Sec. 371 Date Jan. 18, 1995 Sec. 102(e) Date Jan. 18, 1995 PCT Filed May 27, 1993 PCT Pub. No. WO93/25334 PCT Pub. Date Dec. 23, 1993The device for controlling a pour rate according to the invention, which comprises a stationary upper plate (8), a movable plate (10) carried by a carriage (9) and a pouring tube (2). Control of the rate takes place by gliding the movable plate (10) against the upper plate (8), the pouring tube (2) being immobilized against the movable plate (10), just beneath the pouring orifice (27) of the movable plate (10) which blocks the tap hole (15). The immobilization of the pouring tube (2) with respect to the movable plate (10) is obtained by means (31) for pushing upwards which are secured to the carriage (9).
Patent DE-69716393-T3 (DE)
Inventor: GIROTTI LORENZO
IPC: G06K7/10
Filed: 1997-12-04
Granted: 2007-02-01
Abstract: A scanning reader (1) of an optical code (7) placed on a front wall (5) of an article (2) in movement comprises generators (10, 13) that form at least one first and one second light beam (8 alpha , 8 beta ) lying on planes inclined by a first and by a second prefixed angle ( alpha ,  beta ) with respect to the front wall (5) so as to explore a first and a second area of the front wall by means of at least one first and one second scanning line (81, 82) and read said optical code (7) within an overall distance range, along the direction of forward movement of the article (2), greater than the useful range of reading distance that can be reached by one light beam only. <IMAGE>
Patent DE-69726426-T3 (DE)
Inventor: PLOEGH L
IPC: A61P5/00
Filed: 1997-04-22
Granted: 2009-09-10
Abstract: Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.
Patent DK-1062926-T3 (DK)
Inventor: FISCHER WILFRIED DR
IPC: A61F13/02
Filed: 2000-06-26
Granted: 2004-05-17
Abstract: Multilayer dressing has an adhesive layer comprising a central area of flowable adhesive surrounded by a ring of less flowable adhesive.
Patent DK-1159980-T3 (DK)
Inventor: BLOM ERIC D
IPC: A61B17/00
Filed: 2000-06-21
Granted: 2005-12-19
Abstract: An outer cannula has a first port for orienting outside the neck of a wearer, a second port for orienting within the trachea of the wearer, a first passageway coupling the first port to the second port to permit the flow of gases from the first port to the second during inhalation by the wearer and from the second port during exhalation by the wearer, and a third port between the first and second ports. An inner cannula is configured for insertion into the first passageway via the first port when the wearer desires to be able to exhale through his or her pharynx. The inner cannula includes a fourth port for orienting adjacent the first port, a fifth port for orienting adjacent the second port and a second passageway coupling the fourth port to the fifth port to permit the flow of gases from the fourth port to the fifth during inhalation by the wearer and from the fifth port during exhalation by the wearer. A valve controls flow through the third port. The valve assumes a first orientation to permit flow from the first port to the second port when the first port is at a higher pressure than the second port, and a second orientation to permit flow from the second port through the third port when the second port is at a higher pressure than the first port. <IMAGE>
Patent DK-1171695-T3 (DK)
Inventor: STEDHAM DAVID
IPC: G01M99/00
Filed: 2000-03-24
Granted: 2003-03-10
Abstract: A reciprocating piston machine, especially an internal combustion engine, comprises at least one cylinder (Z1, Z2, Z3) having a displaceable piston (13) that is connected to a crankshaft (1) via a connecting rod (9). A thermocurrent (I) is generated when a lubricating film (5) is broken between bearing parts which move relative to one another and which are comprised of different electrically conductive materials, and is generated due to a temperature gradient on such a plain bearing (2a, 10, 11). The thermocurrent (I) is used as a control signal in a control device (14). In order to differentiate between different plain bearings (2, 10, 11) and/or bearing states, the curve of this generated thermocurrent (I) is composed by enlarging and spreading according to the angle of rotation of the crankshaft (1), and the curve obtained is interrogated during a complete operating cycle in order to determine significant symptoms of the plain bearings.
Patent DK-1192463-T3 (DK)
Inventor: LEONARD JOHN E
IPC: G01N33/60
Filed: 2000-02-29
Granted: 2009-10-05
Abstract: Antibody binding assays and radiolabeling kits are disclosed for radiolabeling and testing therapeutic antibodies in the commercial setting. In particular, the kits are designed for making and evaluating radiolabeled anti-CD20 conjugates to be used for the treatment and imaging of B cell lymphoma tumors. All kit reagents are sterile and are designed to achieve a high level of antibody radiolabeling and product stability with results which are highly reproducible.
Patent DK-1169588-T3 (DK)
Inventor: MOELLMANN DIETER
IPC: F16K1/22
Filed: 2000-04-20
Granted: 2004-07-12
Abstract: The invention relates to a shut-off flap for pipelines, with a flap disc which is pivotable relative to an axis of rotation in a housing and which, in the sealing position, closes the throughflow through the housing in the region of a seal. The particular feature of the shut-off valve according to the invention is that the flap disc (32) is self-closing in both flow directions.
Patent DK-1210772-T3 (DK)
Inventor: RENOVELL MICHEL
IPC: H03M1/10
Filed: 2000-09-07
Granted: 2004-01-05
Abstract: A device for self-testing of an analog-to-digital converter includes elements for applying to the converter test signals and analyzing elements. The analyzing elements include common resources (10,36) integrated in the circuit bearing the converter and capable of being configured to determine successively shift, gain and non-linearities of the converter and elements for configuring and controlling the common resources (10,36) so as to adapt them to the characteristics to be determined.
Patent DK-1209548-T3 (DK)
Inventor: WOELPER CHRISTIAN
IPC: G05D23/19
Filed: 2001-06-09
Granted: 2003-09-22
Abstract: The temperature in a sauna or steam bath is controlled by using a touch-screen (4) to select menu functions (6). The screen output is fed to a micro-controller (8) and this operates a number of relays (10) each of which is coupled to an output device.
Patent DK-1201264-T3 (DK)
Inventor: LAUER MARTIN
IPC: A61M39/00
Filed: 2001-10-23
Granted: 2006-12-27
Abstract: An arrangement for supplying and/or branching off a side flow from a main liquid medicine stream, comprises a liquid supply member (1) with a main channel (2) open on one side, and a side channel (4) with a connection to the main channel. A cover film (3) is located over the liquid supply member, and the side channel connection can be closed off by the film. The side channel is arranged so the main channel has no dead spaces.
Patent DK-1254398-T3 (DK)
Inventor: SZARVAS GABOR
IPC: G11C17/00
Filed: 2001-02-07
Granted: 2005-08-15
Abstract: There is disclosed a method for the holographic recording of data, wherein a hologram containing the date is recorded in a waveguide layer (3). The holograms are formed in a layer structure containing multiple waveguide layers (3). Coupling means (12) are provided for selectively coupling the reference beam (11) into the single waveguide layers (3) of the layer structure. The invention also relates to an arrangement for holographic recording of data, comprising a data storage medium with a waveguide holographic storage layer, and an optical system for writing and reading the holograms. The optical system comprises means for imaging an object beam (5) and a reference beam (11) on the storage medium. The arrangement comprises multiple waveguide holographic storage layers (3) in the storage medium, and means for selectively coupling the reference beam (11) into the single waveguide layers (3) of the layer structure.
Patent DK-1322480-T3 (DK)
Inventor: POT STEPHANE
IPC: B42D25/00
Filed: 2001-09-26
Granted: 2007-03-12
Abstract: The invention relates to a recording medium comprising an upper layer (2) having a plurality of lenticular lenses (6) arranged on the outer side (7) thereof and a display element (8) on the rear side which can be displaced when the recording medium is tilted around at least one axis (D).  Said lenticular lenses (6) extend exclusively along one section of the above-mentioned outer side (7).  The display element (8) is a security element which is applied to an inner card layer.  The recording medium is characterised in that it has a particularly high anti-counterfeit security factor.
Patent DK-1275925-T3 (DK)
Inventor: EICHNER FRANK
IPC: B08B9/027
Filed: 2002-07-05
Granted: 2007-06-18
Abstract: Process for local destruction of compact material, e.g. clinker coating, masonry remains, etc., in hot thermal systems such as heat exchangers, industrial ovens, furnaces, and metallurgical melting vessels, uses an explosive (5) arranged on the front end of a lance (3) in a cooling container (1) through which coolant (4) flows. The explosive is inserted through an opening in the hot thermal system directly adjacent to the material to be destroyed by holding and moving the rear end of the lance and is ignited by an ignition device. The coolant flows into the cooling container designed as a double tube having a cooling head (10) and a supply head (11) over the lance into the supply head, through the inner tube/inner cooling casing (27) to the front end of the cooling head, past the explosive container (25), between the inner cooling casing and the cooling head housing (23) back to the supply head, and from this out of the hot thermal system. An Independent claim is also included for a device for carrying out the above process.
Patent DK-1381402-T3 (DK)
Inventor: NAERHI TIMO
IPC: A61F2/82
Filed: 2002-04-25
Granted: 2010-03-08
Abstract: A method for improving soft tissue attachment which includes the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiO2 and/or SiO2, and applying the coating where soft tissue attachment is desired. An implant in which a surface or surfaces of the implant intended to be attached to soft tissue are coated with a porous coating rich in TiO2 and/or SiO2, and the use of a porous surface coating rich in TiO2, SiO2, or TiO2 and SiO2, for the manufacture of an implant for soft tissue attachment are also disclosed.
Patent DK-1438052-T3 (DK)
Inventor: TREIBERG JENNIFER
IPC: A61P31/04
Filed: 2002-08-27
Granted: 2011-03-14
Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.