baber/WOPTO huggingface dataset:
Patent CA-2363621-A1 (CA)
Title: A novel inhibitor of programmed cell death
Inventor: HARDWICK J MARIE
IPC: A61K35/76
Filed: 2000-02-24
Abstract: The present invention provides a human apoptosis regulator protein (Aven) an d polynucleotides which identify and encode Aven. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Aven, and a method for producing Aven. The invention also provides for agonists, antibodies, or antagonists specificall y binding Aven, and their use, in the prevention and treatment of diseases associated with expression of Aven. Additionally, the invention provides for  the use of antisense molecules to polynucleotides encoding Avent for the treatment of diseases associated with the expression of Aven. The invention also provides diagnostic assays which utilize the polynucleotide, or fragmen ts or the complement thereof, and antibodies specifically binding Aven.
Patent CA-2365717-A1 (CA)
Title: Constructional elements
Inventor: FLEMING JOHN JOSEPH
IPC: E04B1/62
Filed: 2001-12-18
Abstract: A structural panel (1) has a structural frame (2) of interconnected structural members (10, 15, 16, 17) of cold-rolled steel material. EPS insulation (3) is integrally moulded around the structural members to a combined depth of the members and wall tie brackets (4) extending outwardly. There is minimal surface area contact between each bracket (4) and a structural member (10) to minimise cold bridging. Wall ties (5) connect to the brackets (4) by engagement of a hooks (56) on the wall ties (5) with slots (51) in the brackets, again with minimal area of contact.
Patent CA-2367350-A1 (CA)
Title: Melanges a mouler hautement conducteurs et plaques bipolaires de pile a combustible comprenant ces melanges
Inventor: BUTLER KURT I
IPC: H01M8/02
Filed: 2000-03-17
Abstract: L'invention concerne un polymère conducteur qui convient dans des applications exigeant une résistance à la corrosion, notamment en cas d'écoulement acide à des températures allant de  40 à plus de 140 degrés Fahrenheit, et que l'on peut mouler sous forme d'échantillons particulièrement minces complexes présentant une conductivité constante, une résistance et une souplesse suffisante, ainsi que des caractéristiques de surface appropriées. En particulier, l'invention concerne le moulage de composition de résine en prépolymère insaturé pourvu de charges élevées d'éléments de remplissage conducteurs. Outre le fait d'activer les caractéristiques nécessaires, les compositions contiennent des modificateurs rhéologiques tels que des oxydes et hydroxydes Groupe II; des carbodiamides; des aziridines; des polyisocyanates; des polytétrafluoroéthylène (PTFE); des perfluoropolyéther (PFPE), et du polyéthylène. L'action de ces modificateurs permet nettement de changer le poids moléculaire apparent et des structures de réseau tridimensionnelles en prépolymère et, par conséquent, de corriger les carences rhéologiques susceptibles d'entraîner une séparation particulaire de résine excessive pendant le processus de moulage, ainsi que d'importantes variances au niveau de la conductivité en profondeur à travers la surface de la plaque. La composition s'applique dans des piles électrochimiques et des piles à combustible.
Patent CA-2367752-A1 (CA)
Title: Weldable aluminium alloy structural component
Inventor: MECHSNER KLAUS ALFONS
IPC: C22C21/06
Filed: 2000-03-17
Abstract: Improved shape and strength of the weld in a welded structure are obtained by use of a weldable aluminium product comprising a structural component which is a sheet, a plate or an extruded body and is made of an aluminium alloy containing not more than 1.5 wt % Zn. This component has, adhered on at least one side, a cladding layer made of an AA7xxx-series alloy having a corrosion potential lower than that of said alloy of said structural component. The alloy of the structural component is preferably an AA5xxx-series alloy containing Mg in the range 2 to 6 wt %.
Patent CA-2368651-A1 (CA)
Title: Fast-dissolving isotropic expanded microporous composition or structure for pharmaceutical, veterinary, dietetic, food or cosmetic and use and method for obtaining same
Inventor: BOUGARET JOEL
IPC: A61K9/20
Filed: 2000-03-30
Abstract: The invention concerns a composition for pharmaceutical, veterinary, food, dietetic or cosmetic use, comprising 1 wt. % to 50 wt. % of one or several active principle(s), 50 wt. % to 90 wt. % of a carrier comprising one or several polymer(s), optionally one or several diluent(s) and optionally one or several additive(s), in particular flavouring or colouring additives. Said composition is characterised in that it has a fast-dissolving isotropic microporous expanded structure and the polymers are selected from the group consisting of polymers of plant origin, optionally combined with polymers of animal origin or synthetic polymers, and said carrier is such that the binding polymer(s) are present in the composition in a proportion not less than 1 % (p/p) and more particularly ranging between 6 % and 98 % (p/p). With respect to the polymer(s), it is a polysaccharide of plant origin, optionally modified by chemical or enzymatic process or obtained by chemical or enzymatic hydrolysis which is being particularly referred to.
Patent CA-2374186-A1 (CA)
Inventor: BOURQUI GERALD
IPC: B60L50/16
Filed: 2002-03-08
Abstract: Has energy storage system for at least 70 kJoules to 150 kJoules..   The vehicles electric traction system includes: (a) acceleration and deceleration controller (CA) available to the driver; a processing unit (211,212) for the controller (CA) which checks and evaluates the required engine torque and braking torque; an electrical energy source for traction; an electrical machine (112,231) connected to a drive wheel and coupled to an electrical conductor of the electrical energy source. The electrical machine is capable of operating the engine by absorbing the electrical energy from the electrical conductor and transmitting to the drive wheel a torque. The electrical machine is also capable of operating as a generator by transmitting to the drive wheel a braking torque and returning the electrical energy to the conductor; a storage system (41) for electrical energy from the conductor, the electrical energy storage system consists of one or more super condensers; an operation mode management unit for selecting energy recuperation or restitution; a drive unit (21) for applying torque to the vehicles wheel, which permits (a) at torque demand, the electrical machine to operate as a motor by consuming the stored energy as long as the charge of the storage system is not at a minimum, having priority for use of the energy source for vehicle traction and (b) at a request for braking torque, operate the machine as a generator by using the energy produced to recharge the energy storage system as long as the system charge is not at a maximum, with priority over use of all other braking devices.
Patent CA-2374854-A1 (CA)
Inventor: VIERO TIMO
IPC: H04J13/00
Filed: 1999-05-26
Abstract: The present invention relates to a method and system for performing a random access operation between a mobile station and a network element such as a base transceiver station (10), wherein allowed access slots for random access channels are defined by the network and are signaled to the mobile station (20). The definition of the allowed access slots is performed on the basis of a parameter set by the base transceiver station (10) and transmitted to the mobile station (20) which determines the allowed access slots based on the parameter. Thus, the number of allowed access slots can be defined by the network and can be changed dynamically based on the random access messaging load and the hardware requirements.
Patent CA-2374905-A1 (CA)
Title: Derives de benzopyrane substitues par un pyrrolidinyle, un piperidinyle ou un homopiperidinyle permettant de traiter la relaxation fundique alteree
Inventor: VAN EMELEN KRISTOF
IPC: A61K31/513
Filed: 2000-05-23
Abstract: La présente invention concerne des composés correspondant à la formule (I), une de ses formes stéréochimiquement isomères, ses formes N-oxyde ou ses sels d'addition acide pharmaceutiquement acceptables. Dans cette formule, -Z<1>-Z<2>- représente un radical divalent ; R<1>, R<2> et R<3> sont choisis de manière indépendante parmi un groupe hydrogène, un groupe C1-6 alkyle, un groupe hydroxy, un groupe halo ou analogue, ou si R<1> et R<2> se trouvent sur des atomes de carbone adjacents, ils peuvent être pris ensemble pour former un radical divalent de la formule ; Alk est éventuellement substitué en C1-6 alkanediyle ; le radical divalent (a) est un pipéridinyle substitué, un pyrrolidinyle éventuellement substitué, un homipipéridinyle, un pipérazinyle ou un tropyle ; R<5> représente un radical correspondant à la formule (c-1), (c-2), (c-3), (c-4), (c-5), dans laquelle n est égal à 1 ou à 2 ; p<1> est égal à 0 et p<2> est égal à 1 ou à 2 ; ou p<1> est égal à 1 ou à 2 et p<2> est égal à 0 ; X représente un atome d'oxygène, de soufre ou =NR<9>, Y représente un atome d'oxygène ou de soufre ; R<7> représente un groupe hydrogène, C1-6 alkyle, C3-6 cycloalkyle, phényle ou phénylméthyle ; R<8> représente un groupe C1-6 alkyle, C3-6 cycloalkyle, phényle ou phénylméthyle ; R<9> représente un groupe cyano, C1-6 alkyle, C3-6 cycloalkyle, C1-6 alkyloxycarbonyle ou aminocarbonyle ; R<10> représente un hydrogène ou un groupe C1-6 alkyle ; et Q représente un radical divalent. L'invention concerne également des procédés de préparation de ces produits, des formulations les contenant et leur utilisation en tant que médicaments, notamment pour traiter des états liés au relâchement fundique altéré.
Patent CA-2376267-A1 (CA)
Title: Blowing machine with double cavity moulds
Inventor: LINGLET STEPHANE
IPC: B29C49/06
Filed: 2000-07-03
Abstract: A rotary machine for blowing thermoplastic containers starting with a previously injected preform, comprising several blowing stations (10) each of which can bear a double cavity mould (16), wherein each station includes a blowing unit (26) which is fixed on a mount frame element (22) and provided with two blow nozzles (24). The machine can be transposed into a single cavity configuration wherein each station bears a single cavity mould (36), and the blowing unit (26) includes a second position for being fixed on the mount frame element wherein one of the nozzels (24) is arranged to correspond with the main axis (A4) of the single moulding cavity (38) of the single cavity mound (36).
Patent CA-2377969-A1 (CA)
Title: Oscillator circuit
Inventor: GOLDMAN RICHARD
IPC: H03B5/20
Filed: 2000-06-19
Abstract: An oscillator circuit includes a current generator (4) which supplies current to input terminals of capacitors (C0, C1) in a trimmable capacitor array. The input terminals of the capacitors are held at a relatively constant voltage, and thus all of the current from the current generator passes through the desired capacitors of the capacitor array, thus minimizing the effetct of parasitic capacitance.
Patent CA-2378949-A1 (CA)
Inventor: STEVENS JOHN
IPC: A61K47/10
Filed: 2000-07-11
Abstract: Liquid growth hormone formulations are storage stable for more than six mont hs at temperatures in the range 2-8 ~C by simply formulating growth hormones in  phosphate buffer with no other additives at around physiological pH. By ensuring a pH of about 6.2 or greater, growth hormone crystallisation during  storage at refrigeration temperatures or above is inhibited or reduced. Low concentrations of non-ionic surfactant can help to reduce aggregation of growth hormone arising as a result of physical forces encountered during automated transfer of bulk formulation into dosage containers. Mannitol is included in order to provide an isotonic formulation. Preservatives are included to reduce bacterial contamination and thereby permit multiple dosag e units which can be stored at 2-8 ~C.
Patent CA-2380009-A1 (CA)
Inventor: MURALI RAMACHANDRAN
IPC: A61P1/02
Filed: 2000-07-28
Abstract: L'invention concerne des méthodes destinées à inhiber l'ostéoclastogenèse et l'activité des ostéoclastes. L'invention concerne également des méthodes de traitement de patients atteints de maladies caractérisées par une perte osseuse. La présente invention concerne en outre des peptides et des analogues de peptides mis au point à partir d'une boucle de fixation d'un élément de la superfamille de récepteurs de facteur de nécrose tumorale (TNF-R). Selon ces méthodes, on administre au patient une quantité d'inhibiteur efficace pour inhiber l'ostéoclastogenèse. L'invention concerne également des méthodes de modulation de la maturation des cellules dendritiques, de la prolifération des lymphocytes T, et/ou des systèmes récepteurs CD40 chez un individu. Ces méthodes consistent à administrer à l'individu une quantité d'inhibiteur efficace pour moduler la maturation des cellules dendritiques, la prolifération des lymphocytes T, et/ou les systèmes récepteurs CD40.
Patent CA-2380674-A1 (CA)
Inventor: PHILIPPE MICHEL
IPC: C07C273/18
Filed: 2002-04-05
Abstract: The present invention relates to novel compounds corresponding to formula (I) below:The invention also relates to the process for manufacturing them, to their use as pigments and to a cosmetic composition comprising them.
Patent CA-2386175-A1 (CA)
Title: Network-based sweepstakes system and method
Inventor: DAUGHERTY FRANK W
IPC: G06Q30/02
Filed: 2000-10-04
Abstract: A system and method for automatically enrolling users of a website (31) or other network-based service in sweepstakes (6). A user of a user computer system connects to a host computer system hosting a website (31) or other network-based service and is awarded points (5) for accessing features of the website or service (31). The points (5) are displayed in real-time on the user's computer and transmitted to a database server (4), which maintains the user's point totals. The user is then automatically given a number of entries in a sweepstakes (6) based on the number of points he or she has been awarded.  Users may also be awarded points for accessing features of websites or services of third-party host computer systems.
Patent CA-2389085-A1 (CA)
Title: Method of and apparatus for high tolerance brush honing
Inventor: SHAFFER WILLIAM R
IPC: B24B3/00
Filed: 2000-07-05
Abstract: The present invention relates to a honing method and apparatus which provides greater control over the edge shape, as well as reductions in the effort required to hone multiple edges on workpieces. The invention accomplishes these improvements by controlling the speed of the abrasive brush (20), as well as the orientation and position of the workpiece (22) prior to and/or while it is in contact with the abrasive brush (20). This provides for greater control over the hone shape, hone size, and hone distribution along the cutting edges of the tool.
Patent CA-2390569-A1 (CA)
Title: High voltage cable
Inventor: GORRELL BRIAN E
IPC: H01B9/04
Filed: 2002-06-13
Abstract: A high voltage cable includes a fiber core, a first layer of electrically relatively non-insulative polymer, a second layer of electrically relatively non-conductive polymer, a third layer of electrically relatively non-insulative polymer, a fourth layer including a braided wire shield, and a fifth layer including a solvent- and abrasion-resistant polymer jacket.
Patent CA-2391130-A1 (CA)
Inventor: CAO YUN-WEI
IPC: H01L33/08
Filed: 2001-09-03
Abstract: The invention relates to new semiconductor composite nanocrystal materials having desirable luminescent properties, specifically high quantum yields an d good photochemical stability with specific, desirable emittance wavelengths,  preferably in the near infrared. The invention further relates to various applications in optical, electrical, electro-optical and laser devices, particularly in the field of telecommunication, of these new semiconductor composite nanocrystal materials.
Patent CA-2394740-A1 (CA)
Title: Method for obtaining proteins having improved functional characteristics
Inventor: DAY ANTHONY G
IPC: C12N15/09
Filed: 2000-12-14
Abstract: An improved protein comprising an amino acid sequence which has been modifie d from a precursor amino acid sequence by the substitution or deletion of an amino acid residue which differs from a corresponding amino acid residue in a less stable but homologous protein, wherein said improved protein has improv ed properties compared to a protein corresponding to the precursor amino acid sequence.
Patent CA-2396232-A1 (CA)
Inventor: BALBONTIN GIULIO
IPC: C08F10/00
Filed: 2001-09-24
Abstract: Constituants de catalyseur pour la polymérisation d'oléfines, qui comprennent Mg, Ti, halogène et au moins deux composés donneurs d'électrons, ce dernier constituant étant caractérisé en ce qu'au moins un des composés donneurs d'électrons, présent à raison de 20 à 50 % par mole par rapport à la quantité totale des donneurs, est choisi parmi les esters d'acides succiniques qui ne sont pas extractibles pour plus de 25 % par mole et en ce qu'au moins un autre composé donneur d'électrons est extractible pour plus de 35 %. Lesdits constituants de catalyseur permettent d'obtenir des polymères à haute insolubilité au xylène, à haute teneur en stéréoséquences et à large répartition du poids moléculaire, ce qui permet de produire des polymères pouvant être utilisés dans le secteur des films de polypropylène bi-orientés.
Patent CA-2397091-A1 (CA)
Inventor: ONOFREY THOMAS J
IPC: C07H21/04
Filed: 2000-08-11
Abstract: Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on  the biomolecule or through use of branched phosphoramidite moieties that can  be added in multiple to form dendritic structures which can in turn provide attachment sites for substrate binding moieties. Substrate binding moieties may include noncovalent binding moieties. For covalent binding moieties oligonucleotides containing hydrazides are provided. These hydrazides can be  introduced via protected building blocks such as phosphoramidites or via building blocks containing precursor forms of such hydrazides.
Patent CA-2397217-A1 (CA)
Title: Barbecue grill assembly with a shelf component
Inventor: SIEG EWALD
IPC: F16L19/08
Filed: 2002-08-09
Abstract: The present invention provides a barbecue grill assembly 10 comprising an upper frame assembly 12 and a lower frame assembly 14. The lower frame assembly 14 comprises a shelf 50 and a plurality of lower frame members 26, 28 which define an interior space 40. At least one frame member 28 has an aperture 80. The shelf 50 has at least one pin 70 cooperatively dimensioned with the aperture 80. The pin 70 is received by the aperture 80 to connect the shelf 50 to the lower frame members 26, 28 and form the lower frame assembly 14. The shelf 50 has a perimeter that is cooperatively dimensioned with the interior space 40 such that the shelf 50 is positioned within the interior space 40.  The shelf 50 provides structural integrity to the lower assembly 14 such chat the lower assembly 14 can support the upper assembly 12 and the cooking chamber 16.
Patent CA-2397355-A1 (CA)
Inventor: RUMPH TIMOTHY
IPC: F16D65/06
Filed: 2002-08-09
Abstract: A brake shoe adapted to engage the tread of a railroad car wheel via which such railroad car is guidably supported on a railed track. The brake shoe comprises a backing plate which has a predetermined configuration and a means disposed on each end of the backing plate for securing such backing plate to a brake head. The brake shoe further includes a brake lining that is affixed to the backing plate and has a braking surface engageable with the wheel tread of a railroad car wheel.
Patent CA-2399202-A1 (CA)
Title: Use of recombinant antigens to determine the immune status of an animal
Inventor: JENSEN WAYNE A
IPC: C07K14/13
Filed: 2001-03-07
Abstract: The present invention includes a method to determine the immune status of an  animal that includes the steps of (a) contacting a biological specimen of th e animal with a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent, under conditions suitable for formation of a complex between the recombinant antigen and the antibody and (b) detecting the presence or absence of the complex, wherein presence or absence of a complex is indicative of the immune status of the animal. Preferably such a method indicates whether the animal should be vaccinated. The present invention also includes an assay comprising (a) a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent; and (b) a means to detect an antibody that selectively binds to the recombinant antigen. Also included in  the present invention are recombinant antigens and nucleic acid molecules encoding such antigens as well as methods to produce and use such nucleic ac id molecule and recombinant antigens.
Patent CA-2400818-A1 (CA)
Inventor: WASSINK SANDRA E
IPC: A61P31/04
Filed: 2001-02-23
Abstract: An antibiotic product for delivering at least two different antibiotics or antifungals that is comprised of three dosage forms with different release profiles with each antibiotic or antifungal being present in at least one of the dosage forms.
Patent CA-2401552-A1 (CA)
Inventor: RASTELLI LUCA
IPC: C12N15/09
Filed: 2001-03-05
Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeuctic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids  and proteins.
Patent CA-2402038-A1 (CA)
Title: Lpa receptor agonists and antagonists and methods of use
Inventor: SARDAR VINEET M
IPC: A61P17/02
Filed: 2001-03-19
Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors: such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
Patent CA-2403691-A1 (CA)
Inventor: SCHMITZ HAROLD H
IPC: A61K31/616
Filed: 2001-03-22
Abstract: L'invention se rapporte à l'utilisation des procyanidines du cacao combinées à de l'aspirine en tant que traitement anti-plaquettaire et à des compositions contenant des procyanidines du cacao et de l'aspirine (acide acétylsalicylique).
Patent CA-2409412-A1 (CA)
Title: Plastic bushing
Inventor: BYCZEK ROGER
IPC: H05K5/00
Filed: 2001-05-03
Abstract: An enclosure 30 including a housing 32 adn a plurality of plastic bushings 34, 36, 38, 40 is disclosed. The plastic bushing 34 includes a pair of ends 90, 92, both with an aperture 96, 97, a bore 98 running between the apertures, and a flange 100 with a poly-sided perimeter. The flange 100 engages the housing 32 such that the bushing 34 is translationally and rotationally fixed relative to the housing 32. The plastic bushing 34 may include a plurality of glass fibers 140 aligned with a longitudinal axis of the bore. The plastic bushing 34 may be electrolytic dissolution resistant and corrosion resistant. The plastic bushing 34 may have a thermal coefficient matching that of the plastic housing 32.