baber/WOPTO huggingface dataset:
Patent EP-3950686-A1 (EP)
Inventor: ZHU CHENGGANG
IPC: A61K31/519
Filed: 2020-03-30
Abstract: The present application relates to azaaromatic amide derivatives for the treatment of cancer. Specifically, the present application relates to a preparation method and use of azaaromatic amide derivatives. The present application relates to azaaromatic amide derivatives and anilino-pyrimidine compounds represented by formula (I), formula (II), formula (III), formula (IV), and formula (V), and pharmaceutically acceptable salts thereof; the compounds or salts thereof can be used to treat or prevent a disease or disorder by regulating certain mutant forms of epidermal growth factor receptors. The present application also relates to a pharmaceutical composition comprising the compounds or salts thereof, and a method for treating various diseases mediated by EGFR, or HER2, or HER4 by using the compounds and salts thereof.
Patent EP-3946562-A1 (EP)
Title: Générateur d'impulsions pouvant être implanté pour fournir une thérapie par neuro-stimulation à l'aide de mesures d'impédance complexes et procédés de fonctionnement
Inventor: DESHAZO DARAN
IPC: A61N1/18
Filed: 2020-03-10
Abstract: Selon des modes de réalisation, l'invention concerne un dispositif médical pouvant être implanté qui comprend un circuit de stimulation thérapeutique pour commander l'administration d'une thérapie médicale à un patient, le circuit de stimulation thérapeutique ayant au moins un conducteur ayant des électrodes pour administrer la thérapie médicale. Le dispositif médical pouvant être implanté comprend en outre un circuit de mesure pour déterminer des caractéristiques du ou des conducteurs, un processeur pour commander l'IMD selon un code exécutable, et une mémoire pour stocker des données et un code exécutable, le code exécutable comprenant des instructions pour amener le processeur à recevoir une pluralité de mesures de tension associées aux électrodes, et à calculer des valeurs pour un modèle d'impédance de l'interface électrode/tissu.
Patent EP-4201019-A1 (EP)
Inventor: CAMENISCH JAN
IPC: H04L9/08
Filed: 2020-09-30
Abstract: Method for redistribution of a (n,t)-secret sharing of a secret s from a set of dealers to a set of receivers. The method comprises performing by each of at least the threshold number t of dealers, - creating a (n',t')-secret sharing of its respective secret share, - creating a set of ciphertexts comprising for each receiver one encrypted sub-share of the n1 secret sub-shares of its respective secret share and being encrypted with respect to a public encryption key of the respective receiver. The public encryption key is a key of a public-key encryption scheme. - generating a non-interactive zero-knowledge proof that the set of ciphertexts jointly contain a redistribution of its secret share - broadcasting a dealing to the set of receivers, the dealing comprising the set of ciphertexts for the set of receivers and the corresponding non-interactive zero-knowledge proof.
Patent EP-4037597-A1 (EP)
Inventor: BOWLING DAVID GENE
IPC: A61B34/10
Filed: 2020-09-30
Abstract: Systems and methods are provided for guiding movement of a tool. The system comprises a tool and a manipulator. A guide handler obtains a target state for the tool and generates virtual constraints based on the target state and a current state of the tool. A constraint solver calculates a constraint force adapted to attract the tool toward the target state or repel the tool away from the target state based on the virtual constraints. A virtual simulator simulates dynamics of the tool in a virtual simulation based on the constraint force and input from one or more sensors, to output a commanded pose. The control system commands the manipulator to move the tool based on the commanded pose to thereby provide haptic feedback to the user that guides the user toward placing the tool at the target state or away from the target state.
Patent EP-4038751-A1 (EP)
Inventor: HUANG YI
IPC: H04B7/0456
Filed: 2020-10-02
Abstract: Wireless communications systems and methods related to wireless communications in a system are provided. A user equipment (UE) may transmit to a base station (BS), an indication of a maximum transmit power capability of the UE. The UE may receive from the BS, a transmit precoding configuration based on the UE's maximum transmit power capability. Additionally, the UE may transmit to the BS, a communication signal using the transmit precoding configuration.
Patent EP-3958880-A1 (EP)
Inventor: GAY JOEL
IPC: C12N9/16
Filed: 2020-04-24
Abstract: The present disclosure provides improved genome editing compositions and methods for editing a human Wiskott-Aldrich syndrome gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of WAS, including but not limited to, an immune system disorder, thrombocytopenia, eczema, X-linked thrombocytopenia (XLT), or X-linked neutropenia (XLN).
Patent EP-3962483-A1 (EP)
Inventor: BELL IAN M
IPC: A61K31/64
Filed: 2020-04-27
Abstract: The present disclosure relates to compounds of formula (I) that are useful as modulators of 7α nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
Patent EP-3976077-A1 (EP)
Inventor: NAMBIAR KALYANI
IPC: A61K35/761
Filed: 2020-04-28
Abstract: Provided herein are novel AAV capsids and rAAV comprising the same. In one embodiment, vectors employing a novel AAV capsid show increased transduction of a selected target tissue as compared to a prior art AAV.
Patent EP-3937286-A1 (EP)
Inventor: OH JEONG WOO
IPC: H01M10/0567
Filed: 2020-04-24
Abstract: The present invention relates to a non-aqueous electrolyte for a lithium secondary battery, which includes an organic solvent, a lithium salt, and a compound represented by Formula 1, and a lithium secondary battery including the same.
Patent EP-4041212-A1 (EP)
Inventor: PLANZ OLIVER
IPC: A61K31/196
Filed: 2020-10-07
Abstract: La présente invention concerne des inhibiteurs de MEK qui sont capables de présenter un ou plusieurs effets thérapeutiques bénéfiques. Les inhibiteurs de MEK peuvent être utilisés dans la prévention et/ou le traitement d'une infection à hantavirus.
Patent EP-4051677-A1 (EP)
Title: Bicyclic nitrogen containing heterocycles as inhibitors of salt-inuced kinase sik2
Inventor: SIME MAIRI
IPC: A61K31/4375
Filed: 2020-10-30
Abstract: Provided are compounds of the Formula (I), and salts and solvates thereof: (Formula (I)) wherein R 2 , R 3 , X 1 , L, A, R 6 , R 7  and Z are defined in the specification. The compounds are inhibitors of salt-inducible kinase (SIK), particular SIK2, and are useful in therapy, particularly in the treatment of a proliferative disorder, a benign neoplasm, pathological angiogenesis, an inflammatory disease or condition, a musculoskeletal disease or condition, an autoimmune disease, a haematological disease or condition, a neurological disease or condition, a psychiatric disorder, or a metabolic disorder.
Patent EP-3965819-A1 (EP)
Title: Treatment of brain ischemia-reperfusion injury
Inventor: CAMICI GIOVANNI GUIDO
IPC: A61K39/395
Filed: 2020-04-30
Abstract: The sequelae of cerebral ischemia-reperfusion injury are reduced by administering to the subject a pharmaceutical composition that includes a pharmaceutically acceptable carrier and a therapeutically effective amount of an agent that selectively binds IL-lα.
Patent EP-4054347-A1 (EP)
Inventor: KRÜGER MARC
IPC: B67D1/04
Filed: 2020-11-04
Abstract: The invention relates to a method for producing a beverage in portions, wherein a beverage concentrate portion is mixed with a water portion, said water portion being mixed with carbon dioxide prior to being mixed with the beverage concentrate. The invention additionally relates to a device for producing a beverage in portions, wherein a beverage concentrate portion is mixed with a water portion, said water portion being mixed with carbon dioxide in a static mixer prior to being mixed with the beverage concentrate.
Patent EP-4205330-A1 (EP)
Inventor: BOUDREAU GARY
IPC: H04B7/15
Filed: 2020-10-30
Abstract: Un procédé, un système et un appareil, destinés à une configuration de duplexage par répartition dans le temps (TDD) adaptative robuste aux interférences avec de multiples points de transmission-réception (multi-TRP), sont divulgués. Un procédé mis en œuvre dans un nœud sans fil comprend les étapes suivantes : la détermination d'au moins une ressource temporelle dans laquelle au moins une partie d'une première configuration de duplexage par répartition dans le temps, TDD, utilisée dans un premier réseau prise en charge par un premier nœud de réseau ne correspond pas à une seconde configuration TDD utilisée dans un second réseau prise en charge par un second nœud de réseau ; et l'application d'au moins une procédure d'atténuation d'interférence au moins pendant l'au moins une ressource temporelle.
Patent EP-3969122-A1 (EP)
Title: Procédés de caractérisation et méthodes d'utilisation d'interactions agent-condensat
Inventor: YOUNG RICHARD A
IPC: G01N33/50
Filed: 2020-05-15
Abstract: L'invention concerne des procédés de caractérisation de l'incorporation d'un agent dans des condensats, des méthodes de réduction de la transcription d'oncogènes associés à des condensats et des méthodes d'utilisation de peptides pour inhiber la liaison d'un récepteur nucléaire et d'un cofacteur dans des condensats.
Patent EP-4062251-A1 (EP)
Inventor: BRACH HARALD
IPC: G05D16/20
Filed: 2020-11-19
Abstract: The invention presented relates to a device (100) for setting a pressure in a system. The device (100) comprises at least one movable adjustment unit (109), having at least one opening, and a fluid channel (101). The fluid channel (101) comprises a main opening (105), having a flow region for the outflow of a main stream (101b) of fluid to be conveyed through the fluid channel (101), and a secondary-stream opening (107), having a flow region for the outflow of a secondary stream (102a) of the fluid to be conveyed through the fluid channel (101), to an outer environment of the device (100). The adjustment unit (109) is configured to at least partially overlie the secondary-stream opening (107) in a working position and thereby reduce the flow region of the secondary-stream opening (107).
Patent EP-4252145-A1 (EP)
Inventor: GYLLENHAMMAR MAGNUS
IPC: G08G1/0968
Filed: 2020-11-26
Abstract: The present disclosure relates to a method (100) for augmenting capabilities of an Automated Driving System (ADS) of a vehicle. The method comprises locally processing (101), by means of a perception module of the ADS, sensor data obtained from one or more sensors of the vehicle in order to generate a local world-view of the ADS. The sensor data is associated with a time period and comprises information about a surrounding environment of the vehicle during the time period. The method further comprises generating (102) a local candidate path to be executed by the ADS based on the generated local world-view of the ADS, and transmitting (103) a first set of data to a remote system. The first set of data is associated with the time period and comprising information about the surrounding environment of the vehicle during the time period. Furthermore, the method comprises receiving (104) off-board processed data from the remote system, where the off-board processed data is indicative of a supplementary candidate path to be executed by the ADS. Moreover, the method comprises selecting (105) a path, from the local candidate path and the supplementary candidate path based on at least one constraint, for execution by the ADS, and generating (106), at an output, a signal indicative of the selected path for execution.
Patent EP-4064871-A1 (EP)
Inventor: BAILEY CHELSEA
IPC: A24D1/20
Filed: 2020-11-27
Abstract: The invention provides a substrate comprising an aerosol-generating material, the aerosol-generating material comprising a thermoreversible amorphous solid, the thermoreversible amorphous solid comprising: 0.5 - 20 wt% of iota- and/or kappa-carrageenan; 20 - 80 wt% of an aerosol-former material; 20 - 70 wt% of a flavourant and/or an active substance; wherein these weights are calculated on a dry weight basis.
Patent EP-4240465-A1 (EP)
Title: Access needle indication systems for locating and accessing subcutaneous medical devices
Inventor: PRECHTEL ERICKA J
IPC: A61M39/02
Filed: 2020-11-24
Abstract: Embodiments disclosed herein are directed to access devices configured to access a subcutaneous medical device. The access device can include a needle supported by a needle hub and in some embodiments a housing slidably engaged therewith and configured to align the needle axis at a predetermined angle. The access device can include an indicator system configured to detect when the needle is correctly aligned with a target window of a port. This can allow for smaller, lower profile ports with smaller target windows while mitigating mis sticks. The indicator system can be contained within the access device little or no increase to the overall size of the access device. The indicator system can employ various modalities including capacitance, induction, magnetic, thermal, acoustic, or radio frequency (RF).
Patent EP-4073501-A1 (EP)
Inventor: POOL WIEBEREN
IPC: G01N27/38
Filed: 2020-12-11
Abstract: An electrochemical sensor device has a working electrode, a counter electrode and preferably a reference electrode on a sensing surface. The sensor is useful for anodic stripping voltammetry and other measurements using an electrochemical sensor device in a flowing liquid, wherein the electrical potential on the working electrode is repeatedly scanned. The working electrode comprises an array of boron doped diamond layer microelectrodes, each micro-electrode having an exposed area of less than a hundred square micrometer surrounded by an electrically insulating area. An edge of the counter electrode lies at least one millimeter above the sensing surface. This increases the speed at which the scans can be repeated with reliable results, by promoting the creation of turbulence that removes bubbles that develop on the counter electrode.
Patent EP-4172526-A1 (EP)
Inventor: CRAVINHO SANTOS RUNO RICARDO
IPC: F16L21/04
Filed: 2020-11-30
Abstract: The present disclosure belongs to the field of restraining connections for pipe couplings. The present subject-matter discloses a pipe coupling to apply in structures for laying and restraining pipes with a circular cross section. In particular, the pipe coupling of the present disclosure may be used to establish longitudinally sealed and force- locked connections with PVC or PE pipes. It comprises a coupling sleeve (3) for receiving an end of the pipe (4) to be restrained and having a first annular abutment surface; a clamping ring (2) having a second annular abutment surface, a pipe collar formed by wedge- shaped segments (15) comprising a support body (10) and a gripper (11) arranged to be placed between the pipe and the support body (10), an annular seal (13) for sealing the sleeve (3) to the pipe (4),
Patent EP-4078017-A1 (EP)
Title: BELEUCHTUNGSSYSTEM FÜR AUßENBEREICHE
Inventor: PIER HARALD
IPC: F21V17/00
Filed: 2020-12-16
Abstract: Ein Beleuchtungssystem (10) zur Beleuchtung von Außenbereichen (5), wie z.B. einem Sportplatz, wird beschrieben. Das Beleuchtungssystem (10) umfasst eine Vielzahl von Leuchten (10) umfassend eine Vielzahl von Beleuchtungselementen (20), angeordnet in einer nicht-koplanaren Weise auf einem Rahmen (50) oder in mindestens einem Gehäuse (11), zum Erzeugen einer Vielzahl von Lichtstrahlen (25) mit einer optischen Achse (23) im Wesentlichen in Richtung der Außenbereiche (5) und mindestens ein Abschirmelement (21), angeordnet in einem oberen Bereich (22) der Vielzahl von Beleuchtungselementen (20), derart angeordnet, um mindestens einen Teil der Vielzahl von Lichtstrahlen (25) in Richtung des Horizonts (8) und darüber der Erde weg abzuschirmen.
Patent EP-3998235-A1 (EP)
Title: Positive electrode active material for lithium ion secondary batteries, and lithium ion secondary battery
Inventor: KOSHIKA YUKI
IPC: H01M4/505
Filed: 2020-06-30
Abstract: A positive electrode active material that can achieve high thermal stability at low cost is provided.Provided is, for example, a positive electrode active material for a lithium ion secondary battery, the positive electrode active material containing a lithium-nickel composite oxide having a hexagonal layered structure and configured by secondary particles with a plurality of aggregated primary particles, in which the lithium-nickel composite oxide contains lithium (Li), nickel (Ni), manganese (Mn), titanium (Ti), niobium (Nb), and optionally an element M1, an amount of substance ratio of the respective elements is represented as Li : Ni : Mn : M : Ti : Nb = a : (1 - x1 - y1 - b - c) : x1 : y1 : b : c (provided that, 0.95 ≤ a ≤ 1.25, (1 - x1 - y1 - b - c) < 0.80, 0.03 ≤ x1 ≤ 0.35, 0 ≤ y1 ≤ 0.35, 0.005 ≤ b ≤ 0.05, and 0.001 < c ≤ 0.03), in the amount of substance ratio, (b + c) ≤ 0.06 and b > c are satisfied, and an amount of lithium to be eluted in water when the positive electrode active material is immersed in water is 0.07% by mass or less with respect to the entire positive electrode active material.
Patent EP-4259702-A1 (EP)
Inventor: YANG YUNFENG
IPC: C08J9/00
Filed: 2020-12-14
Abstract: The present disclosure relates to polyolefin foam beads comprising one or more polyolefin interpolymers, wherein the foam bead has a gel content of higher than or equal to 80% and a tan delta at 1 rad/s of lower or equal to 0.11 and a process for producing the same. The present disclosure further relates to an element prepared from the foam beads, a product comprising the element, and use of the foam beads in bead-filling applications.
Patent EP-4065022-A1 (EP)
Title: Systems and methods for turbinate reduction
Inventor: DOLL SEAN
IPC: A61B18/14
Filed: 2020-12-17
Abstract: An electrosurgical wand for reducing tissue is disclosed. The wand includes a handle and an elongate shaft, the shaft having a major longitudinal axis, a conduit extending 5 therethrough and a non-insulated distal end portion defining a first electrode. The first electrode has a distal most edge configured to mechanically pierce tissue, and an arcuate surface extending proximally from the distal most edge along the major longitudinal axis, the arcuate surface having a convex surface that faces in a distal direction. First and second arcuate edges define lateral edges of the arcuate surface. A second electrode is disposed 10 at an opening of the conduit and electrically isolated from the first electrode. The second electrode comprises an aperture, configured to aspirate fluid and tissue debris therethrough.
Patent EP-4001443-A1 (EP)
Inventor: SUGAWARA KEIICHI
IPC: C22B5/02
Filed: 2020-07-06
Abstract: There is provided a method for recovering PGM, in which at least one base metal oxide selected from a group consisting of copper oxide, iron oxide, tin oxide, nickel oxide and lead oxide is added to and melted in a molten slag, and a PGM alloy contained in the molten slag is recovered.
Patent EP-4009055-A1 (EP)
Title: Reagent cartridge
Inventor: TANIMOTO NORIO
IPC: G01N35/02
Filed: 2020-07-31
Abstract: Provided is a reagent cartridge that can reduce the risk of infection caused by an operator touching a sample or the like during dispensation of the sample or handling of the reagent cartridge, can shorten the test time by improving the work efficiency, and can positively perform analysis of the sample. 
     A reagent cartridge used for an analysis apparatus that analyzes a result based on the reaction of a sample and a reagent includes a sample containing part that contains the sample, a reagent containing part that contains the reagent, and an antibody containing part that contains the antibody, wherein the sample containing part, the reagent containing part, the antibody containing part, and the sample containing part are arranged on the same surface, and the sample containing part includes an injection part and a liquid suction part.
Patent EP-3993589-A1 (EP)
Inventor: FUJINO SHINKURO
IPC: H05K9/00
Filed: 2020-07-21
Abstract: An electronic board includes: a board including an upper surface ground on an upper surface; at least one first land formed on the upper surface and connected to a first signal line; at least one second land formed on the upper surface and connected to a second signal line; at least one third land disposed on the upper surface between the first land and the second land and connected to the upper surface ground; and at least one fourth land disposed on the upper surface on a side opposite to the third land and connected to the upper surface ground, the first land being interposed between the third land and the fourth land.
Patent EP-4014978-A1 (EP)
Inventor: LI DONG
IPC: A61K31/585
Filed: 2020-07-30
Abstract: A combination product containing limonoid (and a derivative, ester, a stereoisomer, salt or prodrug thereof that are pharmaceutically acceptable) and an α-glucosidase inhibitor (acarbose, acarbose derivative, voglibose, miglitol and the like). The combination product is used for treating and/or preventing diabetes-related diseases and the like.
Patent EP-4013401-A1 (EP)
Inventor: TRAVERSO CARLO GIOVANNI
IPC: A61K33/04
Filed: 2020-08-12
Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.
Patent EP-4018086-A1 (EP)
Inventor: SHAVER GREGORY M
IPC: F02D41/00
Filed: 2020-08-24
Abstract: A system and method for dynamically deactivating engine cylinders of an engine equipped with a cylinder deactivation system, where the system and method control torsional vibration in the engine while deactivating cylinders using a computer programed with a desired firing density and a controlled range of engine vibration frequencies. The computer dynamically determines a cylinder firing pattern that provides the desired firing density while optimizing a cost function norm in the controlled range of engine vibration frequencies. The cylinder deactivation system in the engine is then controlled using the determined cylinder firing pattern.
Patent EP-4017936-A1 (EP)
Title: Tetradentate ligands, gold(iii) complexes, preparation method and use thereof
Inventor: TO WAI PONG
IPC: H05B33/14
Filed: 2020-08-24
Abstract: Provides a type of gold (III) complex supported by tetradentate ligand having a structure of formula (I). The light-emitting device prepared by using the complex as a light-emitting layer material or dopant in the light-emitting device has a high external quantum efficiency, and a low efficiency roll-off. In addition, the preparation process of the tetradentate ligand provided in the present disclosure is simple and the yield is satisfactory. More importantly, the preparation reaction of the material is controllable and stable, and has a good reproducibility, and is suitable for industrial application.