Patent SG-11201906660T-A (SG)
Title: Anti-tgf-beta antibodies and their use
Inventor: SHAPIRO GARY
IPC: C07K16/28
Filed: 2018-01-19
Abstract: PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) omit IIl °nolo ow () International Publication Number WO 2018/134681 Al WIPO I PCT (51) International Patent Classification: C07K 16/22 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/IB2018/000088 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,800 20 January 2017 (20.01.2017) US 1730561.8 20 January 2017 (20.01.2017) EP (71) Applicant: SANOFI [FR/FR]; 54, Rue La Boetie, 75008 Paris (FR). (72) Inventors: SHAPIRO, Gary; 15 Intervale Road, Arling- ton, MA 02474 (US). BROWEN, Kevin; c/o Sanofi, 55 Corporate Drive, Mail Code: 55a-505a, Bridgewater, NJ 08807 (US). FINN, Patrick; 472 Dailey Drive, Franklin, MA 02038 (US). GREGORY, Richard, C.; c/o Sanfi, 55 Corporate Drive, Mail Code: 55a-505a, Bridgewater, NJ 08807 (US). KODURI, Rao; c/o Sanofi, 55 Corpo- rate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). LIU, Feng; 3987 Montefrio Ct., San Diego, CA 92130 (US). MALKOVA, Natalia; c/o Sanofi, 55 Corpo- rate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). MANKOO, Parminder; P.O. Box 8174, Foster City, CA 91101 (US). POLLARD, Jack, R.; c/o Sanofi, 55 Cor- porate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). QIU, Huawei; c/o Sanofi, 55 Corporate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). THEIL- HABER, Joachim; c/o Sanofi, 55 Corporate Drive, Mail Code:55a-505a, Bridgewater, NJ 08807 (US). WINTER, Christopher; 169 Bradlee Ave, Swampscott, MA 01907 (US). YU, Marcella; 37129 Spur Way, Fremont, CA 94555 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 1-1 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. I — 00 (54) Title: ANTI-TGF-BETA ANTIBODIES AND THEIR USE 0 (57) : The invention provides an improved pan-TGF-13 antibody for treatment of conditions that are mediated by TGF-13, \" including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction 0 with other immunomodulatory agents such as an anti-PD-1 antibody. (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1