Patent SG-11201408539U-A (SG)
Title: Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof
Inventor: BLANCO-BOSE WILLIAM
IPC: C07D493/06
Filed: 2013-06-27
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/004902 A2 (51) International Patent Classification: A61K31/366 (2006.01) A61K 45/06 (2006.01) A61K31/00 (2006.01) C07D 493/00 (2006.01) C07D 493/06 (2006.01) A61P9/00 (2006.01) A61P 29/00 (2006.01) A61P 25/00 (2006.01) A61P 3/04 (2006.01) A61P3/06 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/665,137 61/712,886 61/791,137 PCT/US2013/048310 27 June 2013 (27.06.2013) English English US US us 27 June 2012 (27.06.2012) 12 October 2012 (12.10.2012) 15 March 2013 (15.03.2013) (71) Applicant: AMAZENTIS SA [CH/CH]; Pare Scientifique EPFL, PSE-C, CH-1024 Ecublens (CH). (72) Inventor; and (71) Applicant : RINSCH, Christopher, L. [US/CH]; 60 Rue de Lausanne, CH-1110 Morges (CH). (72) Inventors: BLANCO-BOSE, William; Chemin Chante- merle 13T, CH-1010 Lausanne (CH). SCHNEIDER, Bernard; Av. des Cerisiers 37, CH-1009 Pully (CH). MOUCHIROUD, Laurent; Avenue de Cour 126, CH- 1007 Lausanne (CH). RYU, Dongryeol; Ch de Bourg-des- sus 20, CH-1020 Renens VD (CH). ANDREUX, Penelope; 3 av d'Evian, CH-1006 Lausanne (CH). AUWERX, Johan; 8 rue Roger de Lessert, CH-1168 Buchillon (CH). (74) Agents: STEELE, Alan, W. et al.; Foley Hoag LLP, Pat­ ent Group, 155 Seaport Boulevard, Boston, MA 02210- 2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) CJ CJ o as o o o CJ O & (54) Title: ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRE­ CURSORS THEREOF (57) Abstract: Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate urolithins and to urolithin precursors and use thereof. Certain urolithins are represen­ ted by Formula while certain I, urolithin precursors are represented by Formula IV. The urolithin may be urolithin A, urolithin B, urolithin C, or urolithin D. The urolithin precursor may be ellagic acid or an ellagitannin. The methods include in vivo, ex vivo, and in vitro uses of the compounds and compositions.