Patent SG-11201810034X-A (SG)
Title: ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE
Inventor: REILLY EDWARD B
IPC: A61K47/68
Filed: 2017-05-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 11 11111111111111 11111111111111111111111110111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201204 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: Declarations under Rule 4.17: A61K 47/68 (2017 .01) — as to applicant's entitlement to apply for and be granted a (21) International Application Number: patent (Rule 4.17(ii)) PCT/US2017/033176 Published: (22) International Filing Date: — with international search report (Art. 21(3)) 17 May 2017 (17.05.2017) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/337,796 17 May 2016 (17.05.2016) US (71) Applicants: ABBVIE BIOTHERAPEUTICS INC. [US/US]; 1500 Seaport Boulevard, Redwood City, Cal- ifornia 94063 (US). ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, Illinois 60064 (US). (72) Inventors: REILLY, Edward B.; 1136 Winners Circle, Libertyville, Illinois 60048 (US). NAUMOVSKI, Louie; _ 570 Jay Street, Los Altos, California 94022 (US). ALLAN, Christian B.; 3434 Glendora Drive, San Mateo, Califor- nia 94403 (US). WANG, Jieyi; 2317 Hastings Drive, Bel- mont, California 94002 (US). ANDERSON, Mark G.; 410 = Sommerset Drive, Grayslake, Illinois 60030 (US). AFAR, = Daniel E.; 12682 Roble Veneno Lane, Los Altos Hills, Cal- — _ — ifornia 94022 (US). (74) Agent: CHAPMAN, Ernest F. et al.; Finnegan, Bender- = = son, Farabow, Garrett & Dunner, LLP, 901 New York Av- enue, NW, Washington, District of Columbia 20001-4413 (US). Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = — SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — 1-1 71' 0 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, N TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 1-1 0 ei KM, ML, MR, NE, SN, TD, TG). IN 1-1 (54) © Title: ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE ei (57) : The present disclosure provides antibody drug conjugates that bind human cMET, their methods of making, and their 0 uses to treat patients having cancer.