baber/WOPTO huggingface dataset:
Patent PT-1143976-E (PT)
Inventor: SCHINAZI RAYMOND F
IPC: C12N15/01
Filed: 2000-01-21
Abstract: The present invention discloses a method for treating HIV that includes administering  beta -D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70(K to N), 90 or the 172 codons of the reverse transcriptase region. Also disclosed is a method for using  beta -D-D4FC as "salvage therapy" to patients which exhibit drug resistance to other anti-HIV agents.  beta -D-D4FC can be used generally as salvage therapy for any patient which exhibits resistance to a drug that induces a mutation at other than the 70(K to N), 90 or the 172 codons.
Patent PT-1254944-E (PT)
Title: Dry compositions containing hydrophobic amino acid
Inventor: YAMASHITA CHIKAMASA
IPC: A61K9/19
Filed: 2000-12-22
Abstract: The invention provides an amino acid usable for reducing and/or preventing the coloration caused by a combined use of saccharide and amino acid, and an amino acid usable as a stabilizer for a dry composition containing a pharmacologically active proteinaceous substance. The invention also provides an anti-coloring agent containing a hydrophobic amino acid as an essential ingredient suitable for preventing the coloration of a dry composition containing a saccharide, a method for preventing the coloration of a dry composition containing a saccharide using a hydrophobic amino acid, and a dry composition containing a pharmacologically active proteinaceous substance which further comprises a saccharide and a hydrophpbic amino acid as a stabilizer.
Patent PT-1128067-E (PT)
Inventor: JOSEPHINE DE PUTTE DANIEL JAN
IPC: F04C28/08
Filed: 2001-02-19
Abstract: The invention relates to a method for controlling a compressor installation with at least one lubricated screw-type compressor element (1) connected to a pressure vessel (11) which is driven by an electric motor (10) which is regulated in function of the compression pressure, and which compresses the gas supplied through the gas inlet conduit (2). The return flow of lubricating agent through the return conduit (7) also is determined by a controlled valve (9) which is provided with a calibrated opening (29) and which is controlled by control means (43) which, as the number of revolutions of the screw-type compressor element (1) has dropped below a well-defined value, put the controlled valve (9) into the position in which it restricts the return flow of lubricating agent to a flow through the calibrated opening (29). <IMAGE>
Patent PT-1341732-E (PT)
Title: Glazing provided with a stack of thin layers for solar protection and/or heat insulation
Inventor: COUSTET VALERIE
IPC: C03C17/36
Filed: 2001-12-12
Abstract: The subject of the invention is glazing comprising at least one transparent substrate provided with a stack of thin layers consisting of an alternation of n functional layers having reflection properties in the infrared and/or the solar radiation range and of n+1 coatings composed of one or more layers made of a dielectric, so that each functional layer is placed between two coatings. At Least one layer absorbent in the visible is inserted between two layers of dielectric of at least one of the said coatings.
Patent PT-1256588-E (PT)
Inventor: HIROYUKI EGAWA
IPC: A61P31/12
Filed: 2001-02-14
Abstract: Pyrazine derivatives represented by general formula Ä1Ü: <CHEM> wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula Ä2Ü: <CHEM> wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula Ä1Ü, and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.
Patent PT-1267940-E (PT)
Inventor: EPENETOS AGAMEMNON ANTONIOU
IPC: A61K38/00
Filed: 2001-03-28
Abstract: A compound comprising a target cell specific portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has the same apoptosis-inducing activity as a caspase. Alternatively, the invention provides a compound comprising a mediator portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has the same apoptosis-inducing activity as a caspase. Preferably, the cytotoxic portion is a constitutively active caspase-3, caspase-6 or caspase-7, and the target cell specific portion is and antibody specific for a tumour cell antigen, such an HMFG-1 antibody. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, such as in the treatment of cancer.
Patent PT-1317559-E (PT)
Title: Dna transfection system for the generation of infectious negative strand rna virus
Inventor: HOFFMANN ERICH
IPC: C12N7/04
Filed: 2001-04-27
Abstract: The present invention is based on the development of a dual promoter system (preferably a RNA pol I -pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. The viral product of the system is produced when the plasmids of the system are introduced into a suitable host cell. One application of the system is production of attenuated, reassortant influenza viruses for use as antigens in vaccines. The reassortant viruses generated by cotransfection of plasmids may comprise genes encoding the surface glycoproteins hemagglutinin and neuraminidase from an influenza virus currently infecting the population and the internal genes from an attenuated influenza virus. An advantageous property of the present invention is its versatility; the system may be quickly and easily adapted to synthesize an attenuated version of any RNA virus. Attenuated or inactivated RNA viruses produced by the present invention may be administered to a patient in need of vaccination by any of several routes including intranasally or intramuscularly.
Patent PT-1336474-E (PT)
Inventor: MICHELI CLAUDIO DE
IPC: B32B27/32
Filed: 2002-07-12
Abstract: The present invention relates to a multiple-layer film to be hot coupled, either on-line and off-line or by an adhesive, to a support layer for food vessels and the like, comprising a base layer which can be coupled to a support layer and a sealing layer, rigid with the base layer and adapted to provide sealing, even in the presence of a contamination on the surface thereof. <IMAGE>
Patent PT-1358441-E (PT)
Title: Reactor and cooler assembly for exothermic reactions
Inventor: BILLIG BARRY
IPC: B01J8/06
Filed: 2002-01-24
Abstract: A reactor and heat exchanger assembly is provided with the heat exchanger integrally affixed to the reactor exit head and adapted to immediately cool reactor gases from the reactor.
Patent PT-1381476-E (PT)
Title: Paper articles exhibiting long term storageability
Inventor: KULKARNI SANDEEP
IPC: D21H21/16
Filed: 2002-04-05
Abstract: A method for increasing the long term storageability of a cellulosic paper or paperboard product. The method includes providing a paper or paperboard product (10) made from cellulosic fibers having a basis weight ranging from about 80 to about 300 pounds per 3000 square feet. A holdout material (12) is applied to at least one surface of the paper or paperboard product. The web is then coated with an ink receptive layer (14) selected from the group consisting of an aqueous acrylic polymer coating material, and aqueous biocidal agent and a combination of aqueous acrylic polymer coating material and aqueous biocidal agent and dried to provide a paper or paperboard product having enhanced long term storageability.
Patent PT-1443915-E (PT)
Title: Pharmaceutical and cosmetic compositions containing oxy group-bearing aromatic aldehydes
Inventor: ENGLES CHARLES R
IPC: A61K8/00
Filed: 2002-08-16
Abstract: Disclosed are pharmaceutical and cosmetic compositions containing oxy group-bearing aromatic aldehyde compounds or acetal derivatives thereof. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
Patent PT-1480674-E (PT)
Title: Treatment of central nervous system damage
Inventor: MCMAHON S B
IPC: A61P25/28
Filed: 2003-03-04
Abstract: The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of chondroitin sulphate proteoglycans. Preferred agents are chondroitinases and sulfatases, e.g. chondroitinase ABC. Also provided are methods of identifying further agents.
Patent PT-1601606-E (PT)
Title: Machine for the aseptic treatment of containers in bottling plant
Inventor: ZANGA FRANCESCO
IPC: B67C3/22
Filed: 2003-01-30
Abstract: Machine for the aseptic treatment of containers ( 10 ) in bottling plant, of the rotary type provided with a plurality of stations ( 9 ) for treating the containers and so shaped as to cause the treatment of the containers to take place under substantially sterile conditions, is characterised in that it comprises sealing means that separate a non sterile area ( 11 ) of the machine from an area ( 12 ) maintained under sterile conditions and in which the treated containers ( 10 ) transit, said means comprising a fixed annular channel ( 15 ) at least partially filled with liquid in which slides a concentric annular element ( 16 ) associated with the rotating part ( 11 ).
Patent PT-1599167-E (PT)
Title: Benzimidazole and imidazopyridine derivatives having affinity for the melanocortin receptors and use thereof as a medicament
Inventor: SACKUR CAROLE
IPC: C07D235/30
Filed: 2004-02-25
Abstract: Benzimidazole and imidazo-pyridine derivatives (I) are new. Benzimidazole and imidazo-pyridine derivatives (I), their racemic and enantiomeric forms and their mixtures and their salts are new. [Image] A : CH 2, CO or C(O)C(R a)(R b); X : C or N; R a, R bH or 1-6C alkyl; R 1, R 2H, 1-8C alkyl (optionally substituted by OH), 2-6C alkenyl or (CH 2) nX 1; X 13-7C cycloalkyl, heterocycloalkyl, aryl or heteroaryl (all optionally substituted by one or more halogen, NO 2, CN or (CH 2) n-V 1Y 1), 1-6C alkoxy or adamantyl; n : 0-6, such that when it is 0, then X 1 is neither OH nor alkoxy; or NR 1R 2heterobicycloalkyl or heterocycloalkyl (both optionally substituted by one or more S 1), 2,5-dihydro-1H-pyrrolo, 1,2,5,6-tetrahydropiperidino or a spirofused group of formula (a); S 1OH, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxycarbonyl or C(O)NV 1'Y 1'; V 1', Y 1'H or 1-6C alkyl; R 3(CH 2) p-Z 3 or C(O)Z' 3; Z 31-6C alkyl, 2-6C alkenyl, 1-6C alkoxy, 1-6C alkoxy carbonyl, 3-7C cycloalkyl or heterocycloalkyl (both optionally substituted by 1-6C alkyl), aryl (optionally substituted by one or more halogen, azido, NO 2 or (CH 2) pV 3Y 3), heteroaryl or a bicyclic group of formula (b) or (c); r : 1 or 2; V 3O, S, C(O), C(O)O, NHC(O), C(O)NR' 3, NHC(O)NR' 3 or a bond; Z' 3aryl (optionally substituted by one or more halogen, NO 2 or (CH 2) pV' 3Y' 3); V' 3O, C(O), C(O)O, C(O)NR' 3, NHC(O)NR' 3 or a bond; Y 3, Y' 3H or 1-6C alkyl (optionally substituted by one or more halogen); R' 3H, 1-6C alkyl or 1-6C alkoxy; R 4(CH 2) sR' 4; R' 4heterocycloalkyl containing at least one N (optionally substituted by 1-6C alkyl or aralkyl), heteroaryl containing at least one N (optionally substituted by 1-6C alkyl) or NW 4W' 4; W 4H or 1-8C alkyl; W' 4(CH 2) s'-Z 4; Z 4H, 1-8C alkyl (optionally substituted by one or more SZ 4), 2-6C alkenyl, 3-7C cycloalkyl (optionally substituted by one or more 1-6C alkyl), cyclohexene, heteroaryl, aryl (optionally substituted by one or more S 4) or a group (b); SZ 41-6C alkoxy, 1-6C alkylthio or OH; S 4(CH 2) s''V 4Y 4, OH, halogen, NO 2 or CN; s'' : 0-4; V 4O, S, NHC(O), N(V' 4) or a bond; V' 4H or 1-6C alkyl; Y 4H or 1-6C alkyl (optionally substituted by one or more halogen); s, s' : 0-6; with the proviso that, when R 3 = C(O)Z' 3 and R 4 = (CH 2) sNW 4W' 4 with W 4 and W' 4 representing H or alkyl, then (CH 2) s is neither ethylene nor -(CH 2)-CH((1-4C) alkyl)-. [Image] An independent claim is also included for preparation of (I). ACTIVITY : Anorectic; Immunomodulator; Tranquilizer; Antidepressant; Analgesic; Vasotropic; Dermatological; Cytostatic. MECHANISM OF ACTION : Melanocortin receptor agonists and antagonists, especially active on MC4.
Patent PT-1703959-E (PT)
Title: Filter for internal combustion engines
Inventor: GIRONDI GIORGIO
IPC: B01D35/30
Filed: 2004-12-23
Abstract: Filter for internal combustion engine liquids, comprising a casing ( 2 ) closed by a removable cover ( 4 ) and containing a toroidal filter cartridge ( 3 ) which separates the casing cavity into two chambers ( 21, 22 ) for passage of the liquid to be filtered and passage of the filtered liquid respectively, in which the inner region of the cover is connected to the facing end of the cartridge by a snap connection system comprising two complementary parts ( 10, 111 ) which are associated with the cover and with the cartridge respectively, and can be connected together by axially sliding said cartridge and released from each other by rotating this latter through a predetermined angle, that part of the system associated with the cartridge being located within the central compartment of this latter, and that part of the system associated with the cover being dimensioned and shaped to be able to be inserted into the preceding and coupled thereto, where it retains the facing end of the cartridge in the immediate vicinity of the inner region of the cover.
Patent PT-1748714-E (PT)
Title: Methods and apparatus for a vegetable spinner
Inventor: OVERTHUN THOMAS
IPC: A47J43/24
Filed: 2004-12-22
Abstract: A vegetable drying device is configured to remove excess moisture from suitably-sized vegetables through a spinning action. The device generally includes an outer bowl, an inner basket, a lid, and a cover assembly, wherein the cover assembly includes a pull-handle and a brake mechanism. The user grasps the handle and pulls outward, thus providing rotational energy, through a suitable mechanical coupling, to the inner basket and lid. The pull handle and attached cord are preferably retractable.
Patent PT-1756364-E (PT)
Title: Fastening rail in railway slide chair assembly
Inventor: SEELEY DAVID RONALD
IPC: E01B9/54
Filed: 2005-06-10
Abstract: A rail fastening apparatus fastens an inner stock rail in a railway slide chair assembly. The apparatus includes a base plate. The base plate has on one face a rail seat region on which the inner stock rail sits when the slide chair assembly is in use. A resilient rail fastening clip restrains the inner stock rail. A locating means locates the rail fastening clip in a first position. A loading means vertically deflects the clip so as to produce a load in a toe portion of the clip. A second locating means holds the rail fastening clip in a second position different from the first position such that the toe portion of the clip sits on a ramp of the loading means in a preload condition in which the clip does not bear on the rail
Patent PT-1828222-E (PT)
Title: Process for the preparation of drospirenone
Inventor: COSTANTINO FRANCESCA
IPC: A61K31/585
Filed: 2005-11-14
Abstract: A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action; comprising the oxidation of 17±-(3-hydroxypropyl)-6²,7²,15²,16²-dimethylene-5²-androstane-3²,5,17²-triol.
Patent PT-1762245-E (PT)
Title: Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
Inventor: MCMASTER RONALD P
IPC: A61K39/095
Filed: 1999-12-16
Abstract: The present invention relates to the removal of unbound polysaccharides from conjugated polysaccharide-protein vaccines using the method of ultrafiltration whereby the diafiltration solution contains saturating levels of ammonium sulfate.
Patent PT-1901988-E (PT)
Title: Cable winch
Inventor: TOBER HERBERT
IPC: B66D1/26
Filed: 2006-05-31
Abstract: The invention relates to a cable winch consists of a cable drum (1) and a drive unit (4) thereof, wherein said cable drum (1) comprises a windable cable (12) and a cable guiding device (2, 3) for guaranteeing that the cable exit (9) is maintained on a fixed output point during operation. The winch elements, in particular the cable drum (1) and the drive unit (4), are mounted on a common support structure (6) and are arranged with respect to the fixed output point in such a way that gravitation forces produced thereby are compensated at least about an axis orthogonally to the vertical cable exit (9).
Patent PT-2231349-E (PT)
Title: Metal panel with cellular structure for use in an impact energy absorber, and related manufacturing process
Inventor: IMPERO PASQUALE
IPC: B21D47/00
Filed: 2008-12-05
Abstract: Metal cellular panel (8) constituting a semifinished product formed by various corrugated plate half shells (1, 1′) wherein all the contact points between the half shells (1, 1′) are welded or riveted, and preferably the axial height (b) of the cells of the panel (panel thickness) does not exceed the maximum diameter of the cells. The panel production process ensures maximum flexibility, since it is adaptable to various cell shapes, various pitches between the cells, and various cell heights (h) (measured in the plane of the panel).
Patent PT-2172718-E (PT)
Title: Method for extending the working life of a solar collector and solar collector
Inventor: LUEKE WOLFGANG
IPC: F24J2/40
Filed: 2009-09-24
Abstract: The method involves summing up operation periods of solar fluid in a definable temperature range critical for fluid. The summed periods are compared to a definable threshold value for operation period, that characterizes achievement of critical solar fluid condition. Condition of the solar fluid is evaluated on the basis of operation period of the solar fluid in a definable temperature range critical for the solar fluid. Maintenance information is provided in dependence of the evaluated condition. An operation period of a solar collector is detected in a temperature range critical for fluid. An independent claim is also included for a device for extending service life of a solar collector, comprising a solar automatic controller.
Patent PT-2296903-E (PT)
Title: Method for printing a covering panel
Inventor: SCHNIEPP JOCHEN
IPC: B41J3/407
Filed: 2009-06-10
Abstract: The invention relates to a method for the contactless printing of a visible surface (10b) of a cladding panel (10) with a first predetermined pattern and at least one visible section (24a, 26a) of the surface of coupling means (24, 26), which are used to connect two panels (10) of this type, with a second predetermined pattern. According to the invention the first and second predetermined patterns are printed on the panel (10) in a contactless manner in a common printing operation, wherein the different spacing (H1, H2, H3) of the visible surface (10b) and of the at least one visible section (24a, 26a) from the printing unit (36) is taken into consideration by means of an adjustment, taking into account this spacing (H1, H2, H3), of the control signals fed to the printing unit (36) for the control thereof.
Patent PT-2398473-E (PT)
Title: 5-(2-{[6-(2, 2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2-(1h)-one for the treatment of lung function
Inventor: RUF THORSTEN
IPC: A61K31/4704
Filed: 2010-02-18
Abstract: A compound which is a hydroxyquinolinone derivative of formula (I),   
in the form of a racemate, a steroisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in normalising the lung function of a human patient.
Patent PT-2459721-E (PT)
Title: Improved human long pentraxin 3 expression system and uses thereof
Inventor: SASSANO MARICA
IPC: C07K14/71
Filed: 2010-07-20
Abstract: The present invention relates to an eukaryotic expression vector comprising a nucleotide sequence encoding for the human long pentraxin PTX3 protein under the control of an effective promoter and a nucleotide sequence encoding for a selectable marker, recombinant human cell able to provide expression of proteins encoded by the vector and method for the production of the human long pentraxin PTX3 protein.
Patent PT-626932-E (PT)
Inventor: STEVENSON DAVID
IPC: C02F9/00
Filed: 1993-01-28
Abstract: The invention relates to a liquid treatment method and apparatus for removing impurities from a liquid stream, comprising forming a zone of micro gas bubbles from a source (3) across substantially the whole surface area of a treatment vessel (12) which is situated above a filter bed (13), passing liquid to be treated into the vessel (12) above the inlet (3) for the air whereby the liquid passes in countercurrent mode through the air bubbles.
Patent PT-681573-E (PT)
Inventor: HOLTON ROBERT A
IPC: C07D305/14
Filed: 1994-01-28
Abstract: Taxane derivatives having alternative C2 substituent which is -OCOR31 wherein R31 is substituted phenyl and the substituent is selected from the group consisting of alkanoxy, protected hydroxy, halogen, alkyl, aryl, alkenyl, acyl, acyloxy, nitro, amino and amido.
Patent PT-699077-E (PT)
Inventor: DEDICO ANTHONY LOUIS
IPC: A01N65/00
Filed: 1994-05-06
Abstract: Neutralizing antibodies against HIV infection are provided. The antibodies are reactive with cryptic epitopes on gp120 and/or CD4 induced by the formation of immunogenic complexes comprising gp120 covalently bonded to CD4 or to succinyl concanvalin A.
Patent PT-732965-E (PT)
Inventor: MALMGREN ULF
IPC: E06C7/18
Filed: 1994-11-23
Abstract: PCT No. PCT/SE94/01117 Sec. 371 Date Jun. 7, 1996 Sec. 102(e) Date Jun. 7, 1996 PCT Filed Nov. 23, 1994 PCT Pub. No. WO95/15790 PCT Pub. Date Jun. 15, 1995A climbing device comprising a safety step having a bent section a pair of aligned straight sections on either side of the bent section.
Patent PT-850304-E (PT)
Title: Cerebellum-derived growth factors, and uses related thereto
Inventor: CHANG HAN
IPC: C12N15/62
Filed: 1996-09-09
Abstract: The present invention relates to the discovery of a novel erbB receptor ligand, referred to hereinafter as "cdGF", which protein has apparently broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in vertebrates, and can be used to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
Patent PT-951575-E (PT)
Inventor: SPRANG WILHELMUS JOHANNA ANTHO
IPC: C22C18/00
Filed: 1997-12-23
Abstract: ZINC ALLOY YIELDING ANTI-CORROSIVE COATINGS ON FERROUS MATERIALS, which includes zinc at a proportion of over 98%, aluminium, and at least one of the following alloy agents: chrome, nickel or vanadium. This alloy is used to obtain an anti-corrosive coating on ferrous materials by means of hot-dip galvanizing, zinc spraying, etc..
Patent PT-917860-E (PT)
Inventor: PURNER HELMUT
IPC: A61C13/20
Filed: 1998-11-10
Abstract: A replacement tooth arrangement comprises a carrier which is anchored on a residual natural tooth and which holds the replacement tooth. The carrier (10) is made of an aromatic thermoplast by injection molding.